PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 2554932-3 1989 In this study, we demonstrated that monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals, and to a lesser extent, hydroxyapatite crystals, increased IL-6 production by synoviocytes and monocytes in vitro. Calcium Pyrophosphate 63-94 interleukin 6 Homo sapiens 171-175 2606144-3 1989 Using 35S-labeled IL 6 cDNA we demonstrated IL 6 gene expression over various areas of the tonsils, with consistent exception of the follicles, by in situ hybridization. Sulfur-35 6-9 interleukin 6 Homo sapiens 18-22 2606144-3 1989 Using 35S-labeled IL 6 cDNA we demonstrated IL 6 gene expression over various areas of the tonsils, with consistent exception of the follicles, by in situ hybridization. Sulfur-35 6-9 interleukin 6 Homo sapiens 44-48 2584704-4 1989 Both GM-CSF or IL-6 inhibited [3H]TdR uptake in U937 cells, and simultaneous treatment with GM-CSF and IL-6 resulted in an additive inhibitory effect on cell proliferation. Tritium 31-33 interleukin 6 Homo sapiens 15-19 2584704-4 1989 Both GM-CSF or IL-6 inhibited [3H]TdR uptake in U937 cells, and simultaneous treatment with GM-CSF and IL-6 resulted in an additive inhibitory effect on cell proliferation. Tritium 31-33 interleukin 6 Homo sapiens 103-107 2584704-7 1989 Treatment with IL-6 also resulted in a dose-dependent reduction of the 17-kDa TNF band revealed by SDS-PAGE after labeling monocytes with [35S]cysteine and immunoprecipitation with anti-TNF mAb. Sodium Dodecyl Sulfate 99-102 interleukin 6 Homo sapiens 15-19 2584704-7 1989 Treatment with IL-6 also resulted in a dose-dependent reduction of the 17-kDa TNF band revealed by SDS-PAGE after labeling monocytes with [35S]cysteine and immunoprecipitation with anti-TNF mAb. Sulfur-35 139-142 interleukin 6 Homo sapiens 15-19 2584704-7 1989 Treatment with IL-6 also resulted in a dose-dependent reduction of the 17-kDa TNF band revealed by SDS-PAGE after labeling monocytes with [35S]cysteine and immunoprecipitation with anti-TNF mAb. Cysteine 143-151 interleukin 6 Homo sapiens 15-19 2511437-7 1989 The 23-bp oligonucleotide designated AR1 from within the IL-6 enhancer region (-173 to -151) contains a CGTCA motif and bound nuclear proteins that also associated with c-fos oligonucleotides containing either an intact SRE or AP-1-like site. Oligonucleotides 175-191 interleukin 6 Homo sapiens 57-61 2554932-3 1989 In this study, we demonstrated that monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals, and to a lesser extent, hydroxyapatite crystals, increased IL-6 production by synoviocytes and monocytes in vitro. Calcium Pyrophosphate 96-100 interleukin 6 Homo sapiens 171-175 2674559-4 1989 In contrast, low levels of IL-1 potentiate the secretion of insulin and thyroid hormones, and intermediate levels of IL-6 double glucose-induced insulin production by beta-cells. Glucose 129-136 interleukin 6 Homo sapiens 117-121 2789018-3 1989 Pulse-chase experiments reveal that newly synthesized IL-6 polypeptides rapidly enter two separate protein modification pathways: one leads to O-glycosylation and the other to both N- and O-glycosylation; polypeptides in both pathways are further modified (phosphorylation) prior to secretion. Nitrogen 181-182 interleukin 6 Homo sapiens 54-58 2789018-5 1989 In the presence of tunicamycin, IL-6 is secreted exclusively in the O-glycosylated form, whereas in the presence of cycloheximide the pathway leading to both N- and O-glycosylation is dominant. Nitrogen 158-159 interleukin 6 Homo sapiens 32-36 2789018-7 1989 Combined immunoprecipitation, immunoblotting, and immunoaffinity chromatography experiments reveal additional IL-6 species with mobilities in sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reducing conditions corresponding to molecular masses 17-19 kDa and 45 kDa, suggesting that this cytokine undergoes further alterations. Sodium Dodecyl Sulfate 142-164 interleukin 6 Homo sapiens 110-114 2806435-0 1989 The role of interleukin 3 and interleukin 6 in the protection from 4-hydroperoxycyclophosphamide and the proliferation of early human hematopoietic progenitor cells. perfosfamide 67-96 interleukin 6 Homo sapiens 30-43 2790194-5 1989 In addition, IL-6 significantly correlated with plasma lactate (P less than .0001), heart rate (P = .05) and, inversely, with mean arterial pressure (P = .01) and platelet counts (P = .0002). Lactic Acid 55-62 interleukin 6 Homo sapiens 13-17 2789325-6 1989 PBMNC spontaneously produced low levels of IL-1 beta and IL-6 that were augmented by the addition of hr IL-1 alpha. pbmnc 0-5 interleukin 6 Homo sapiens 57-61 2663236-2 1989 To circumvent this barrier, we have used synthetic oligonucleotide technology to construct a gene based on the sequence of a cDNA for human interleukin 6 (IL-6). Oligonucleotides 51-66 interleukin 6 Homo sapiens 140-153 2546751-4 1989 In monolayers of HSF, replacing 120 mM NaCl with isoosmotic concentrations of sucrose increases binding of [125I]IGF-I by 2- to 6-fold. Sodium Chloride 39-43 interleukin 6 Homo sapiens 17-20 2546751-7 1989 The binding of [125I]alpha IR-3, a monoclonal antibody to the human type I IGF receptor, to monolayers and suspensions of HSF also depends on the sodium ion concentration; it is 5- to 7-fold higher in the absence of sodium chloride. Sodium 146-152 interleukin 6 Homo sapiens 122-125 2546751-8 1989 Binding of [125I]IGF-I to monolayers of HSF also depends on NaCl under conditions where alpha IR-3 saturates the type I IGF receptor but does not affect IGF-BPs. Sodium Chloride 60-64 interleukin 6 Homo sapiens 40-43 2472117-0 1989 Disulfide structures of human interleukin-6 are similar to those of human granulocyte colony stimulating factor. Disulfides 0-9 interleukin 6 Homo sapiens 30-43 2472117-3 1989 Labeling experiments of recombinant interleukin-6 with tritiated iodoacetate confirmed that the molecule forms two intramolecular disulfide bonds and contains no detectable level of free sulfhydryls. Disulfides 130-139 interleukin 6 Homo sapiens 36-49 2472117-4 1989 By isolation and characterization of tryptic and subtilytic peptides obtained from different proteolytic digestions, the disulfide bonds of the IL-6 molecule were assigned to Cys44-Cys50 and Cys73-Cys83. Disulfides 121-130 interleukin 6 Homo sapiens 144-148 2544300-11 1989 However, IL-6 did "prime" PMN, enhancing superoxide secretion by fMLP (10(-7) M)-treated PMN by 50.8% (5.9 +/- 1.0 to 8.9 +/- 1.5 nmol superoxide at 100 U of IL-6; P less than 0.01) and PMA (5.0 nM) by 54.3% (8.1 +/- 2.6 to 12.5 +/- 3.6 nmol; P less than 0.05). Superoxides 41-51 interleukin 6 Homo sapiens 9-13 2544300-11 1989 However, IL-6 did "prime" PMN, enhancing superoxide secretion by fMLP (10(-7) M)-treated PMN by 50.8% (5.9 +/- 1.0 to 8.9 +/- 1.5 nmol superoxide at 100 U of IL-6; P less than 0.01) and PMA (5.0 nM) by 54.3% (8.1 +/- 2.6 to 12.5 +/- 3.6 nmol; P less than 0.05). Superoxides 135-145 interleukin 6 Homo sapiens 9-13 2544300-11 1989 However, IL-6 did "prime" PMN, enhancing superoxide secretion by fMLP (10(-7) M)-treated PMN by 50.8% (5.9 +/- 1.0 to 8.9 +/- 1.5 nmol superoxide at 100 U of IL-6; P less than 0.01) and PMA (5.0 nM) by 54.3% (8.1 +/- 2.6 to 12.5 +/- 3.6 nmol; P less than 0.05). Tetradecanoylphorbol Acetate 186-189 interleukin 6 Homo sapiens 9-13 2663236-2 1989 To circumvent this barrier, we have used synthetic oligonucleotide technology to construct a gene based on the sequence of a cDNA for human interleukin 6 (IL-6). Oligonucleotides 51-66 interleukin 6 Homo sapiens 155-159 2786697-5 1989 Glucocorticoids strongly inhibit and PGE2 slightly inhibits IL-1-induced IL-6 mRNA expression in synoviocytes. Dinoprostone 37-41 interleukin 6 Homo sapiens 73-77 2651521-5 1989 This secretion was strongly inhibited by estradiol-17 beta at concentrations as low as 10(-9) M. Multiple species of stromal cell IFN-beta 2/IL-6 in the size range 23 to 30 kDa were detected using immunoprecipitation or immunoblotting procedures. Estradiol 41-50 interleukin 6 Homo sapiens 130-140 2651521-5 1989 This secretion was strongly inhibited by estradiol-17 beta at concentrations as low as 10(-9) M. Multiple species of stromal cell IFN-beta 2/IL-6 in the size range 23 to 30 kDa were detected using immunoprecipitation or immunoblotting procedures. Estradiol 41-50 interleukin 6 Homo sapiens 141-145 2651521-5 1989 This secretion was strongly inhibited by estradiol-17 beta at concentrations as low as 10(-9) M. Multiple species of stromal cell IFN-beta 2/IL-6 in the size range 23 to 30 kDa were detected using immunoprecipitation or immunoblotting procedures. (2-benzoylethyl)trimethylammonium 54-58 interleukin 6 Homo sapiens 130-140 2651521-5 1989 This secretion was strongly inhibited by estradiol-17 beta at concentrations as low as 10(-9) M. Multiple species of stromal cell IFN-beta 2/IL-6 in the size range 23 to 30 kDa were detected using immunoprecipitation or immunoblotting procedures. (2-benzoylethyl)trimethylammonium 54-58 interleukin 6 Homo sapiens 141-145 2787245-7 1989 Polymers of oligonucleotides containing either the A or the C regions confer IL-6 responsiveness to a truncated SV40 promoter. Oligonucleotides 12-28 interleukin 6 Homo sapiens 77-81 2785834-4 1989 rIL-1 beta, bradykinin (Bk) and arachidonic acid (AA) significantly stimulated PGE2 release from HSF incubated overnight in the presence of either interleukin. Dinoprostone 79-83 interleukin 6 Homo sapiens 97-100 2476083-8 1989 Both dexamethasone and 13-cis-RA also reduced the mRNA level of glyceraldehyde-3-phosphate dehydrogenase, indicating that glucocorticoids and retinoids have both similar and different effects on gene expression in HSF. Dexamethasone 5-18 interleukin 6 Homo sapiens 214-217 2523818-5 1989 The results suggest that human monocyte IL-6 carries O-glycosidically bound carbohydrates with a Gal(beta 1-3)Gal-NAc core to which only sialic acid is bound. Carbohydrates 76-89 interleukin 6 Homo sapiens 40-44 2523818-7 1989 A small part of IL-6 (27.5 kDa form) is in addition N-glycosylated. Nitrogen 52-53 interleukin 6 Homo sapiens 16-20 2649105-5 1989 Immunoaffinity chromatography followed by Western blotting shows that IL-6 species secreted by IL-1 alpha-induced HUVEC are of molecular mass 23-25, 27-30 and 45 kDa as judged by SDS-PAGE under reducing conditions. Sodium Dodecyl Sulfate 179-182 interleukin 6 Homo sapiens 70-74 2785834-2 1989 Human embryonic skin fibroblasts (HSF) incubated overnight with either human recombinant interleukin-1 alpha (rIL-1 alpha) or interleukin-1 beta (rIL-1 beta) released large amounts of prostaglandin E2 (PGE2). Dinoprostone 184-200 interleukin 6 Homo sapiens 34-37 2785834-2 1989 Human embryonic skin fibroblasts (HSF) incubated overnight with either human recombinant interleukin-1 alpha (rIL-1 alpha) or interleukin-1 beta (rIL-1 beta) released large amounts of prostaglandin E2 (PGE2). Dinoprostone 202-206 interleukin 6 Homo sapiens 34-37 2785834-4 1989 rIL-1 beta, bradykinin (Bk) and arachidonic acid (AA) significantly stimulated PGE2 release from HSF incubated overnight in the presence of either interleukin. Arachidonic Acid 32-48 interleukin 6 Homo sapiens 97-100 3220517-4 1988 The sensitivity of these PLA2s to inhibition by aristolochic acid varied markedly: HSF-PLA2 greater than N. naja PLA2 greater than human platelet PLA2 greater than porcine pancreatic PLA2. aristolochic acid I 48-65 interleukin 6 Homo sapiens 83-86 3220517-5 1988 The inhibition of HSF-PLA2 by aristolochic acid was independent of substrate concentration (18-144 microM) and Ca2+ concentration (0.1-4.0 mM). aristolochic acid I 30-47 interleukin 6 Homo sapiens 18-21 3220517-6 1988 These observations indicate that inhibition of HSF-PLA2 by aristolochic acid may result from direct interaction with the enzyme. aristolochic acid I 59-76 interleukin 6 Homo sapiens 47-50 3220517-7 1988 When aristolochic acid was mixed with HSF-PLA2 and then injected into the mouse foot pad, edema was inhibited in a dose-dependent manner and was positively correlated with in vitro inhibition of PLA2 activity. aristolochic acid I 5-22 interleukin 6 Homo sapiens 38-41 3059347-0 1988 High-level expression of a bioengineered, cysteine-free hepatocyte-stimulating factor (interleukin 6)-like protein. Cysteine 42-50 interleukin 6 Homo sapiens 87-100 3059347-2 1988 Through the use of synthetic oligonucleotide technology, we have constructed a biologically active recombinant IL-6 (rIL-6) gene based on the sequence of a human IL-6 cDNA. Oligonucleotides 29-44 interleukin 6 Homo sapiens 111-115 3059347-2 1988 Through the use of synthetic oligonucleotide technology, we have constructed a biologically active recombinant IL-6 (rIL-6) gene based on the sequence of a human IL-6 cDNA. Oligonucleotides 29-44 interleukin 6 Homo sapiens 118-122 2842790-0 1988 Enhancement of cAMP levels and of protein kinase activity by tumor necrosis factor and interleukin 1 in human fibroblasts: role in the induction of interleukin 6. Cyclic AMP 15-19 interleukin 6 Homo sapiens 148-161 2457950-2 1988 Substance P, substance K, and the carboxyl-terminal peptide SP(4-11) induce the release of interleukin-1, tumor necrosis factor-alpha, and interleukin-6 from human blood monocytes. TFF2 protein, human 60-62 interleukin 6 Homo sapiens 139-152 2460462-2 1988 Phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), partially mimics the stimulatory effect of IL-6 but reduces that effect of IL-1. Tetradecanoylphorbol Acetate 15-51 interleukin 6 Homo sapiens 102-106 2460462-2 1988 Phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), partially mimics the stimulatory effect of IL-6 but reduces that effect of IL-1. Tetradecanoylphorbol Acetate 53-56 interleukin 6 Homo sapiens 102-106 2460462-4 1988 These regulatory properties of TPA are also manifested in HepG2 cells transiently transfected with an indicator gene construct carrying the IL-1/IL-6 regulatory enhancer element of the rat alpha 1-acid glycoprotein gene. Tetradecanoylphorbol Acetate 31-34 interleukin 6 Homo sapiens 145-149 2460462-5 1988 IL-6 and IL-1 act independently of TPA-inducible kinase C, and of changes in intracellular Ca2+ concentrations. Tetradecanoylphorbol Acetate 35-38 interleukin 6 Homo sapiens 0-4 3419505-5 1988 First, an ATP-independent, heat-induced alteration of HSF allows it to bind the HSE; the temperature at which activation occurs in vitro implies that a human factor directly senses temperature. Adenosine Triphosphate 10-13 interleukin 6 Homo sapiens 54-57 2842790-7 1988 The protein kinase inhibitor H-8, inhibiting preferentially cAMP-dependent kinase activity, reduced forskolin-stimulated IL-6 mRNA induction more strongly than TNF- or IL-1-driven IL-6 mRNA induction. N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide 29-32 interleukin 6 Homo sapiens 121-125 2851586-7 1988 As this fused protein had a Phe-Arg-Ala sequence at the junction of hIL-2 and BSF-2, it was possible to process mature BSF-2 from the fused BSF-2 by treatment with kallikrein and aminopeptidase P. From 1 liter of E. coli culture, 45 mg of mature BSF-2 was purified; it had a relative biological activity equal to that of natural BSF-2 purified from T cells. Arginine 32-35 interleukin 6 Homo sapiens 78-83 3260492-5 1988 Cyclosporin A completely blocked induction of lymphotoxin and partially inhibited induction of TNF and IL-6 mRNA. Cyclosporine 0-13 interleukin 6 Homo sapiens 103-107 2851586-7 1988 As this fused protein had a Phe-Arg-Ala sequence at the junction of hIL-2 and BSF-2, it was possible to process mature BSF-2 from the fused BSF-2 by treatment with kallikrein and aminopeptidase P. From 1 liter of E. coli culture, 45 mg of mature BSF-2 was purified; it had a relative biological activity equal to that of natural BSF-2 purified from T cells. Arginine 32-35 interleukin 6 Homo sapiens 119-124 2851586-7 1988 As this fused protein had a Phe-Arg-Ala sequence at the junction of hIL-2 and BSF-2, it was possible to process mature BSF-2 from the fused BSF-2 by treatment with kallikrein and aminopeptidase P. From 1 liter of E. coli culture, 45 mg of mature BSF-2 was purified; it had a relative biological activity equal to that of natural BSF-2 purified from T cells. Arginine 32-35 interleukin 6 Homo sapiens 119-124 2851586-7 1988 As this fused protein had a Phe-Arg-Ala sequence at the junction of hIL-2 and BSF-2, it was possible to process mature BSF-2 from the fused BSF-2 by treatment with kallikrein and aminopeptidase P. From 1 liter of E. coli culture, 45 mg of mature BSF-2 was purified; it had a relative biological activity equal to that of natural BSF-2 purified from T cells. Arginine 32-35 interleukin 6 Homo sapiens 119-124 2851586-7 1988 As this fused protein had a Phe-Arg-Ala sequence at the junction of hIL-2 and BSF-2, it was possible to process mature BSF-2 from the fused BSF-2 by treatment with kallikrein and aminopeptidase P. From 1 liter of E. coli culture, 45 mg of mature BSF-2 was purified; it had a relative biological activity equal to that of natural BSF-2 purified from T cells. Arginine 32-35 interleukin 6 Homo sapiens 119-124 2851586-7 1988 As this fused protein had a Phe-Arg-Ala sequence at the junction of hIL-2 and BSF-2, it was possible to process mature BSF-2 from the fused BSF-2 by treatment with kallikrein and aminopeptidase P. From 1 liter of E. coli culture, 45 mg of mature BSF-2 was purified; it had a relative biological activity equal to that of natural BSF-2 purified from T cells. Alanine 36-39 interleukin 6 Homo sapiens 78-83 2851586-7 1988 As this fused protein had a Phe-Arg-Ala sequence at the junction of hIL-2 and BSF-2, it was possible to process mature BSF-2 from the fused BSF-2 by treatment with kallikrein and aminopeptidase P. From 1 liter of E. coli culture, 45 mg of mature BSF-2 was purified; it had a relative biological activity equal to that of natural BSF-2 purified from T cells. Alanine 36-39 interleukin 6 Homo sapiens 119-124 2851586-7 1988 As this fused protein had a Phe-Arg-Ala sequence at the junction of hIL-2 and BSF-2, it was possible to process mature BSF-2 from the fused BSF-2 by treatment with kallikrein and aminopeptidase P. From 1 liter of E. coli culture, 45 mg of mature BSF-2 was purified; it had a relative biological activity equal to that of natural BSF-2 purified from T cells. Alanine 36-39 interleukin 6 Homo sapiens 119-124 2851586-7 1988 As this fused protein had a Phe-Arg-Ala sequence at the junction of hIL-2 and BSF-2, it was possible to process mature BSF-2 from the fused BSF-2 by treatment with kallikrein and aminopeptidase P. From 1 liter of E. coli culture, 45 mg of mature BSF-2 was purified; it had a relative biological activity equal to that of natural BSF-2 purified from T cells. Alanine 36-39 interleukin 6 Homo sapiens 119-124 2851586-7 1988 As this fused protein had a Phe-Arg-Ala sequence at the junction of hIL-2 and BSF-2, it was possible to process mature BSF-2 from the fused BSF-2 by treatment with kallikrein and aminopeptidase P. From 1 liter of E. coli culture, 45 mg of mature BSF-2 was purified; it had a relative biological activity equal to that of natural BSF-2 purified from T cells. Alanine 36-39 interleukin 6 Homo sapiens 119-124 2454192-2 1988 In the presence of 10(-6) M dexamethasone beta-fibrinogen mRNA levels increased 6-fold after addition of recombinant human IL 6 (rhIL 6). Dexamethasone 28-41 interleukin 6 Homo sapiens 123-127 3133443-5 1988 A rabbit antiserum raised against E. coli-derived human IFN-beta 2/IL-6 was used in immunoprecipitation experiments to monitor the secretion of 35S-methionine-pulse-labeled IFN-beta 2/IL-6 proteins by fibroblasts up to 7 h after the beginning of infection. Sulfur-35 144-147 interleukin 6 Homo sapiens 56-66 3133443-5 1988 A rabbit antiserum raised against E. coli-derived human IFN-beta 2/IL-6 was used in immunoprecipitation experiments to monitor the secretion of 35S-methionine-pulse-labeled IFN-beta 2/IL-6 proteins by fibroblasts up to 7 h after the beginning of infection. Sulfur-35 144-147 interleukin 6 Homo sapiens 67-71 3133443-5 1988 A rabbit antiserum raised against E. coli-derived human IFN-beta 2/IL-6 was used in immunoprecipitation experiments to monitor the secretion of 35S-methionine-pulse-labeled IFN-beta 2/IL-6 proteins by fibroblasts up to 7 h after the beginning of infection. Sulfur-35 144-147 interleukin 6 Homo sapiens 173-183 3133443-5 1988 A rabbit antiserum raised against E. coli-derived human IFN-beta 2/IL-6 was used in immunoprecipitation experiments to monitor the secretion of 35S-methionine-pulse-labeled IFN-beta 2/IL-6 proteins by fibroblasts up to 7 h after the beginning of infection. Sulfur-35 144-147 interleukin 6 Homo sapiens 184-188 3133443-5 1988 A rabbit antiserum raised against E. coli-derived human IFN-beta 2/IL-6 was used in immunoprecipitation experiments to monitor the secretion of 35S-methionine-pulse-labeled IFN-beta 2/IL-6 proteins by fibroblasts up to 7 h after the beginning of infection. Methionine 148-158 interleukin 6 Homo sapiens 56-66 3133443-5 1988 A rabbit antiserum raised against E. coli-derived human IFN-beta 2/IL-6 was used in immunoprecipitation experiments to monitor the secretion of 35S-methionine-pulse-labeled IFN-beta 2/IL-6 proteins by fibroblasts up to 7 h after the beginning of infection. Methionine 148-158 interleukin 6 Homo sapiens 67-71 3133443-5 1988 A rabbit antiserum raised against E. coli-derived human IFN-beta 2/IL-6 was used in immunoprecipitation experiments to monitor the secretion of 35S-methionine-pulse-labeled IFN-beta 2/IL-6 proteins by fibroblasts up to 7 h after the beginning of infection. Methionine 148-158 interleukin 6 Homo sapiens 173-183 3133443-5 1988 A rabbit antiserum raised against E. coli-derived human IFN-beta 2/IL-6 was used in immunoprecipitation experiments to monitor the secretion of 35S-methionine-pulse-labeled IFN-beta 2/IL-6 proteins by fibroblasts up to 7 h after the beginning of infection. Methionine 148-158 interleukin 6 Homo sapiens 184-188 2452159-0 1988 Synthesis of interleukin 6 (interferon-beta 2/B cell stimulatory factor 2) in human fibroblasts is triggered by an increase in intracellular cyclic AMP. Cyclic AMP 141-151 interleukin 6 Homo sapiens 13-45 2452159-0 1988 Synthesis of interleukin 6 (interferon-beta 2/B cell stimulatory factor 2) in human fibroblasts is triggered by an increase in intracellular cyclic AMP. Cyclic AMP 141-151 interleukin 6 Homo sapiens 46-73 2452159-3 1988 We examined the role of the cyclic AMP (cAMP)-dependent signal transduction pathway in IL-6 gene expression. Cyclic AMP 28-38 interleukin 6 Homo sapiens 87-91 2452159-3 1988 We examined the role of the cyclic AMP (cAMP)-dependent signal transduction pathway in IL-6 gene expression. Cyclic AMP 40-44 interleukin 6 Homo sapiens 87-91 2452159-6 1988 Treatments that increased intracellular cAMP also stimulated the secretion of the IL-6 protein in a biologically active form. Cyclic AMP 40-44 interleukin 6 Homo sapiens 82-86 2452159-7 1988 Increased intracellular cAMP appears to enhance IL-6 gene expression by a protein kinase C-independent mechanism because down-regulation of protein kinase C by a chronic exposure of cells to a high dose of 12-O-tetradecanoylphorbol 13-acetate did not abolish the enhancement of IL-6 expression by treatments that increase cAMP. Cyclic AMP 24-28 interleukin 6 Homo sapiens 48-52 2452159-7 1988 Increased intracellular cAMP appears to enhance IL-6 gene expression by a protein kinase C-independent mechanism because down-regulation of protein kinase C by a chronic exposure of cells to a high dose of 12-O-tetradecanoylphorbol 13-acetate did not abolish the enhancement of IL-6 expression by treatments that increase cAMP. Cyclic AMP 24-28 interleukin 6 Homo sapiens 278-282 2452159-7 1988 Increased intracellular cAMP appears to enhance IL-6 gene expression by a protein kinase C-independent mechanism because down-regulation of protein kinase C by a chronic exposure of cells to a high dose of 12-O-tetradecanoylphorbol 13-acetate did not abolish the enhancement of IL-6 expression by treatments that increase cAMP. Cyclic AMP 322-326 interleukin 6 Homo sapiens 48-52 2452159-9 1988 Our results suggest a role for the cAMP-dependent pathway(s) in IL-6 gene activation by TNF and IL-1. Cyclic AMP 35-39 interleukin 6 Homo sapiens 64-68 2821154-8 1987 Several other cell lines, the histiocytic line U937, the promyelocytic line HL60, the astrocytoma line U373 and the glioblastoma line SK-MG-4, in which BSF-2 was inducible with IL-1 or TPA, displayed BSF-2-R with Kd in the range of 1.3-6.4 X 10(-10) M, suggesting the autocrine mechanism in BSF-2 function. Tetradecanoylphorbol Acetate 185-188 interleukin 6 Homo sapiens 152-157 2824651-4 1987 The increase in IFN-beta 2 mRNA level caused by LPS in FS-4 cells is detected within 30 min after addition of LPS, is sustained for at least 20 h thereafter, appears to involve the protein kinase C signal transduction pathway, does not require new protein synthesis, and is inhibited by dexamethasone in a dose-dependent fashion (in the range 10(-6)-10(-8) M). Dexamethasone 287-300 interleukin 6 Homo sapiens 16-26 2452086-12 1988 The inhibition of N-glycosylation by tunicamycin abolished the effect of interleukin-6 on the secretion of alpha 2-macroglobulin, indicating a possible role of interleukin-6 on N-glycosylation. Nitrogen 18-19 interleukin 6 Homo sapiens 73-86 2452086-12 1988 The inhibition of N-glycosylation by tunicamycin abolished the effect of interleukin-6 on the secretion of alpha 2-macroglobulin, indicating a possible role of interleukin-6 on N-glycosylation. Nitrogen 18-19 interleukin 6 Homo sapiens 160-173 2452086-12 1988 The inhibition of N-glycosylation by tunicamycin abolished the effect of interleukin-6 on the secretion of alpha 2-macroglobulin, indicating a possible role of interleukin-6 on N-glycosylation. Nitrogen 177-178 interleukin 6 Homo sapiens 73-86 2452086-12 1988 The inhibition of N-glycosylation by tunicamycin abolished the effect of interleukin-6 on the secretion of alpha 2-macroglobulin, indicating a possible role of interleukin-6 on N-glycosylation. Nitrogen 177-178 interleukin 6 Homo sapiens 160-173 3040777-8 1987 Dexamethasone inhibited the increase of IFN-beta 2 mRNA levels by IL-1 or TNF. Dexamethasone 0-13 interleukin 6 Homo sapiens 40-50 3108877-6 1987 The enhancement of IFN-beta 2 gene expression by diC8, interleukin 1, or tumor necrosis factor was not prevented by H8, a preferential inhibitor of cAMP- and cGMP-dependent protein kinases, but was blocked by H7, an inhibitor of protein kinase C as well as of cyclic nucleotide-dependent protein kinases. Cyclic AMP 148-152 interleukin 6 Homo sapiens 19-29 3108877-8 1987 The calcium ionophore A23187 (1-10 microM) also elicited an increase in the level of IFN-beta 2 mRNA in FS-4 fibroblasts; appropriate combinations of A23187 and diC8 had at least an additive effect in enhancing IFN-beta 2 mRNA levels. Calcium 4-11 interleukin 6 Homo sapiens 85-95 3108877-0 1987 Rapid enhancement of beta 2-interferon/B-cell differentiation factor BSF-2 gene expression in human fibroblasts by diacylglycerols and the calcium ionophore A23187. Calcium 139-146 interleukin 6 Homo sapiens 69-74 3108877-8 1987 The calcium ionophore A23187 (1-10 microM) also elicited an increase in the level of IFN-beta 2 mRNA in FS-4 fibroblasts; appropriate combinations of A23187 and diC8 had at least an additive effect in enhancing IFN-beta 2 mRNA levels. Calcium 4-11 interleukin 6 Homo sapiens 211-221 3494671-1 1987 The effect of a B-cell differentiation factor (BCDF) found in the supernatant of the human bladder carcinoma cell line T-24 (T-24.BCDF) was assessed using the human lymphoblastoid line CESS (Muraguchi et al., 1981) and TPA-stimulated human B-CLL B cells. Tetradecanoylphorbol Acetate 219-222 interleukin 6 Homo sapiens 16-45 3494671-1 1987 The effect of a B-cell differentiation factor (BCDF) found in the supernatant of the human bladder carcinoma cell line T-24 (T-24.BCDF) was assessed using the human lymphoblastoid line CESS (Muraguchi et al., 1981) and TPA-stimulated human B-CLL B cells. Tetradecanoylphorbol Acetate 219-222 interleukin 6 Homo sapiens 47-51 3085988-1 1986 Sequential extraction of human spleen membranes with sodium cholate and n-butanol removes endogenous lipids and renders glucocerebrosidase activity dependent upon exogenous acidic lipids (e.g., phosphatidylserine, gangliosides) and a heat-stable activator protein (HSF). Sodium Cholate 53-67 interleukin 6 Homo sapiens 265-268 3494192-5 1987 Exposure of cells to TNF enhanced IFN-beta 2 (but not IFN-beta 1) mRNA expression in response to poly(I).poly(C), an IFN inducer which is also known to stimulate FS-4 cell growth. Poly I 97-104 interleukin 6 Homo sapiens 34-44 3834057-7 1985 These results suggested a possibility that the different effects of MII on the growth of HSF and MSF might be due partly to differences in the effect of MII on fatty acid synthesis between human and rodent cells. Fatty Acids 160-170 interleukin 6 Homo sapiens 89-92 3006091-2 1986 The specific binding and internalization of human 125I-labeled LDL are dose-dependently increased in HSF by CA of the verapamil series (verapamil, anipamil, gallopamil, ronipamil, and diltiazem), but neither by CA of the dihydropyridine series (nifedipine, nitrendipine) nor by flunarizine. ronipamil 169-178 interleukin 6 Homo sapiens 101-104 4084549-5 1985 Of special interest, tyrosine A, phenylalanine A, tryptophan B1, and tryptophan B2 were found to be located close to a cluster of aliphatic residues, indicating that the hydrophobic site of the HSF is conformationally rigid and its tertiary structure very compact. Tryptophan 50-60 interleukin 6 Homo sapiens 194-197 6601516-1 1983 A product of histamine-stimulated human lymphocytes, histamine-induced suppressor factor or HSF, was characterized by enzyme treatment, sensitivity to reduction and alkylation, by molecular sieve chromatography, and by polyacrylamide gel electrophoresis. Histamine 13-22 interleukin 6 Homo sapiens 92-95 3966907-5 1985 Pretreatment of HSF with 50 microM verapamil for 24 hours and incubation with 2 to 50 micrograms 125I-LDL protein/ml for 1 hour resulted in a 50% to 200% increase in heparin releasable and in a 40% to 130% increase in cellular 125I-LDL. Heparin 166-173 interleukin 6 Homo sapiens 16-19 6233230-8 1984 Prostaglandin E2 production by atopic monocytes exposed to HSF was less than that of normal monocytes in the absence of the drug. Dinoprostone 0-16 interleukin 6 Homo sapiens 59-62 6604743-0 1983 Reduced production of histamine-induced suppressor factor (HSF) by atopic mononuclear cells and decreased prostaglandin E2 output by HSF-stimulated atopic monocytes. Dinoprostone 106-122 interleukin 6 Homo sapiens 133-136 6352807-4 1983 Recently, histamine, by interaction with histamine-type 2 receptors on T lymphocytes, has been found to induce the production of one lymphokine, histamine-induced suppressor factor (HSF), that inhibits lymphocyte proliferation and lymphokine production in vitro. Histamine 10-19 interleukin 6 Homo sapiens 145-180 6352807-4 1983 Recently, histamine, by interaction with histamine-type 2 receptors on T lymphocytes, has been found to induce the production of one lymphokine, histamine-induced suppressor factor (HSF), that inhibits lymphocyte proliferation and lymphokine production in vitro. Histamine 10-19 interleukin 6 Homo sapiens 182-185 6352808-0 1983 Sequential induction of phospholipid methylation and serine esterase activation in a B cell differentiation factor (BCDF)-stimulated human B cell line. Phospholipids 24-36 interleukin 6 Homo sapiens 85-114 6352808-0 1983 Sequential induction of phospholipid methylation and serine esterase activation in a B cell differentiation factor (BCDF)-stimulated human B cell line. Phospholipids 24-36 interleukin 6 Homo sapiens 116-120 6352808-1 1983 The incubation of CESS cells with BCDF induced phospholipid methylation, i.e., 3H-methyl incorporation into phosphatidylcholine and phosphatidyl-N-monomethyl-ethanolamine, within 15 to 30 min. Phospholipids 47-59 interleukin 6 Homo sapiens 34-38 6352808-1 1983 The incubation of CESS cells with BCDF induced phospholipid methylation, i.e., 3H-methyl incorporation into phosphatidylcholine and phosphatidyl-N-monomethyl-ethanolamine, within 15 to 30 min. Tritium 79-81 interleukin 6 Homo sapiens 34-38 6352808-2 1983 A threefold increase of 3H-DFP-binding was also observed in BCDF-stimulated CESS cells 2 hr after stimulation, showing the activation of serine esterase after phospholipid methylation. Tritium 24-26 interleukin 6 Homo sapiens 60-64 6352808-2 1983 A threefold increase of 3H-DFP-binding was also observed in BCDF-stimulated CESS cells 2 hr after stimulation, showing the activation of serine esterase after phospholipid methylation. Phospholipids 159-171 interleukin 6 Homo sapiens 60-64 6352808-3 1983 The inhibitors of methyltransferase, SIBA, adenosine, or HEH showed a dose-dependent inhibitory effect not only on phospholipid methylation but also on serine esterase activation and on BCDF-induced IgG production; DFP inhibited IgG production but not phospholipid methylation. Adenosine 43-52 interleukin 6 Homo sapiens 186-190 6352808-3 1983 The inhibitors of methyltransferase, SIBA, adenosine, or HEH showed a dose-dependent inhibitory effect not only on phospholipid methylation but also on serine esterase activation and on BCDF-induced IgG production; DFP inhibited IgG production but not phospholipid methylation. Phospholipids 115-127 interleukin 6 Homo sapiens 186-190 6352808-3 1983 The inhibitors of methyltransferase, SIBA, adenosine, or HEH showed a dose-dependent inhibitory effect not only on phospholipid methylation but also on serine esterase activation and on BCDF-induced IgG production; DFP inhibited IgG production but not phospholipid methylation. Phospholipids 252-264 interleukin 6 Homo sapiens 186-190 6352808-5 1983 These results showed that BCDF stimulation induced phospholipid methylation that set the stage for serine esterase activation and IgG induction. Phospholipids 51-63 interleukin 6 Homo sapiens 26-30 6440265-9 1984 The NADPH-cytochrome c (P450) reductase of G6PD-deficient HL and HSF homogenates becomes lower than that of controls when endogenous G6PD and exogenous glucose 6-phosphate (G6P) and NADP+ are used as a hydrogen donor system in place of NADPH. Hydrogen 202-210 interleukin 6 Homo sapiens 65-68 6578348-8 1983 Arachidonate metabolites from HSF may contribute to the pathogenesis of crystal-provoked synovitides. Arachidonic Acid 0-12 interleukin 6 Homo sapiens 30-33 6573232-0 1983 Augmentation of prostaglandin and thromboxane production in vitro by monocytes exposed to histamine-induced suppressor factor (HSF). Prostaglandins 16-29 interleukin 6 Homo sapiens 90-125 6573232-0 1983 Augmentation of prostaglandin and thromboxane production in vitro by monocytes exposed to histamine-induced suppressor factor (HSF). Prostaglandins 16-29 interleukin 6 Homo sapiens 127-130 6573232-3 1983 Moreover, the addition of exogeneous PGE2 (10(-7)-10(-8) M) to mononuclear cell cultures reconstituted HSF activity in the presence of indomethacin. Dinoprostone 37-41 interleukin 6 Homo sapiens 103-106 6573232-6 1983 Monocytes (but not lymphocytes) incubated with supernatants containing HSF increased their production of prostaglandin E2, F2 alpha, and thromboxane B2 by 169, 53, and 49%, respectively. Dinoprostone 105-121 interleukin 6 Homo sapiens 71-74 6573232-9 1983 Collectively, these data suggest that HSF-mediated inhibition of lymphocyte proliferation may occur in part through the augmented production of prostaglandins and/or thromboxane B2 by human monocytes. Prostaglandins 144-158 interleukin 6 Homo sapiens 38-41 6601516-1 1983 A product of histamine-stimulated human lymphocytes, histamine-induced suppressor factor or HSF, was characterized by enzyme treatment, sensitivity to reduction and alkylation, by molecular sieve chromatography, and by polyacrylamide gel electrophoresis. Histamine 53-62 interleukin 6 Homo sapiens 92-95 6840389-7 1983 Fibronectin protects both HSF and HGF from the effects of extracellular ATP. Adenosine Triphosphate 72-75 interleukin 6 Homo sapiens 26-29 6946268-6 1981 Prostaglandin production is also related to senescence in human skin fibroblasts (HSF). Prostaglandins 0-13 interleukin 6 Homo sapiens 82-85 6216286-3 1983 HSF was produced by incubating lymphocytes from normal subjects with 10(-4) M histamine. Histamine 78-87 interleukin 6 Homo sapiens 0-3 7002285-4 1980 17 beta-estradiol had no effect on the extranuclear protease activities, or resistance to CDSC, but it increased DNA and protein synthesis in HSF and HNMEC cell lines. Estradiol 3-17 interleukin 6 Homo sapiens 142-145 33727094-9 2021 The interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFalpha) release of SGCs increased after cisplatin exposure as measured using ELISA, and interleukin-1beta (IL-1beta) decreased. Cisplatin 100-109 interleukin 6 Homo sapiens 4-17 33662150-12 2021 Together, Nanog expression appears related to poor prognosis in esophageal cancer patients, and inhibition of stemness and compensatory IL-6 secretion by iron chelators may offer a novel therapeutic strategy for esophageal cancer. Iron 154-158 interleukin 6 Homo sapiens 136-140 33727094-9 2021 The interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFalpha) release of SGCs increased after cisplatin exposure as measured using ELISA, and interleukin-1beta (IL-1beta) decreased. Cisplatin 100-109 interleukin 6 Homo sapiens 19-23 33887367-6 2021 The signature apparently relates to TNF- alpha, IL-1alpha, IL-1beta, IFN-alpha, IFN-beta, and IFN-gamma signaling, but not IL-6 signaling, suggesting that therapeutic effect of dexamethasone in COVID-19 does not involve IL-6 pathway. Dexamethasone 177-190 interleukin 6 Homo sapiens 220-224 33840589-9 2021 IL-6 and IL-10 were closely associated with white blood cells, neutrophils, T lymphocyte subsets, D-D dimer, blood urea nitrogen, complement C1q, procalcitonin C-reactive protein. Urea 115-119 interleukin 6 Homo sapiens 0-4 33259720-7 2021 There were significant differences in inflammatory markers between the two groups: interleukin-6 (p = 0.0001), procalcitonin (p = 0.0001), and C-reactive protein (p = 0.0001) were lower in the dexamethasone group. Dexamethasone 193-206 interleukin 6 Homo sapiens 83-96 33840589-9 2021 IL-6 and IL-10 were closely associated with white blood cells, neutrophils, T lymphocyte subsets, D-D dimer, blood urea nitrogen, complement C1q, procalcitonin C-reactive protein. Nitrogen 120-128 interleukin 6 Homo sapiens 0-4 33934954-2 2021 In the current meta-analysis, we attempted to clarify the efficacy of curcumin/turmeric supplementation in reducing concentrations of interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha in patients with an inflammatory background. Curcumin 70-78 interleukin 6 Homo sapiens 154-158 33934954-3 2021 The main databases were searched to identify eligible trials evaluating the effect of curcumin in reducing IL-1, IL-6, IL-8, and TNF-alpha in serum up to March 2021. Curcumin 86-94 interleukin 6 Homo sapiens 113-117 33934954-7 2021 Nonetheless, curcumin/turmeric supplementation was non-significantly associated with reduced levels of IL-6 (WMD = -0.33 pg/ml, 95% CI = -0.99-0.34, P = 0.33) and increased levels of IL-8 (WMD = 0.52 pg/ml, 95% CI = -1.13-2.17, P = 0.53). Curcumin 13-21 interleukin 6 Homo sapiens 103-107 33893003-6 2021 In in vitro studies, we identified that IL-6R expression or IL-6 and TGF-beta1 secretions were significantly increased in, respectively, Mphis and PSCs by ethanol (EtOH) or lipopolysaccharide (LPS) stimulation while EtOH- or LPS-induced alpha-SMA or Col1a1 mRNA and protein production in PSCs were partially blocked by IL-6 antibody. Ethanol 155-162 interleukin 6 Homo sapiens 40-44 33893003-6 2021 In in vitro studies, we identified that IL-6R expression or IL-6 and TGF-beta1 secretions were significantly increased in, respectively, Mphis and PSCs by ethanol (EtOH) or lipopolysaccharide (LPS) stimulation while EtOH- or LPS-induced alpha-SMA or Col1a1 mRNA and protein production in PSCs were partially blocked by IL-6 antibody. Ethanol 155-162 interleukin 6 Homo sapiens 60-64 33893003-6 2021 In in vitro studies, we identified that IL-6R expression or IL-6 and TGF-beta1 secretions were significantly increased in, respectively, Mphis and PSCs by ethanol (EtOH) or lipopolysaccharide (LPS) stimulation while EtOH- or LPS-induced alpha-SMA or Col1a1 mRNA and protein production in PSCs were partially blocked by IL-6 antibody. Ethanol 164-168 interleukin 6 Homo sapiens 40-44 33893003-6 2021 In in vitro studies, we identified that IL-6R expression or IL-6 and TGF-beta1 secretions were significantly increased in, respectively, Mphis and PSCs by ethanol (EtOH) or lipopolysaccharide (LPS) stimulation while EtOH- or LPS-induced alpha-SMA or Col1a1 mRNA and protein production in PSCs were partially blocked by IL-6 antibody. Ethanol 164-168 interleukin 6 Homo sapiens 60-64 33893003-6 2021 In in vitro studies, we identified that IL-6R expression or IL-6 and TGF-beta1 secretions were significantly increased in, respectively, Mphis and PSCs by ethanol (EtOH) or lipopolysaccharide (LPS) stimulation while EtOH- or LPS-induced alpha-SMA or Col1a1 mRNA and protein production in PSCs were partially blocked by IL-6 antibody. Ethanol 216-220 interleukin 6 Homo sapiens 40-44 33580540-2 2021 Metformin is known to decrease interleukin-6 (IL-6) and tumor-necrosis alpha (TNFalpha), which appear to contribute to morbidity in COVID-19. Metformin 0-9 interleukin 6 Homo sapiens 31-44 33580540-2 2021 Metformin is known to decrease interleukin-6 (IL-6) and tumor-necrosis alpha (TNFalpha), which appear to contribute to morbidity in COVID-19. Metformin 0-9 interleukin 6 Homo sapiens 46-50 33930649-11 2021 The green tea extract and EGCG also had a dose-dependent inhibitory effect on irinotecan-induced secretion of interleukin-6 and interleukin-8 by oral epithelial cells. Irinotecan 78-88 interleukin 6 Homo sapiens 110-123 34057209-11 2021 Long-term exposure of HGFs to nicotine or CSC significantly suppressed their cellular proliferation and migration and upregulated type I collagen, type III collagen, interleukin (IL)-6, IL-8, p16, p21, and p53 mRNA expression, and IL-6 and IL-8 protein expression. Nicotine 30-38 interleukin 6 Homo sapiens 166-184 33404763-12 2021 Ten-minute NAC treatment downregulated the IL-6 and TNF-alpha expression, whereas the expression of Bcl-2/Bax and Mfn-2/Drp-1 ratios was upregulated at 6 h. CONCLUSIONS: Under the LPS-induced inflammatory condition, NAC stimulated APC survival and decreased inflammation. Acetylcysteine 11-14 interleukin 6 Homo sapiens 43-47 33503268-12 2021 NAC supplementation to the MTA extract significantly reduced the level of IL-6 and TNF-alpha expression (P<0.05). Acetylcysteine 0-3 interleukin 6 Homo sapiens 74-78 32712770-4 2021 In contrast, ziram at 10 mumol.L-1 completely inhibited this phagocytic process, the oxidative burst triggered by zymosan and the production of TNF-alpha, IL-1beta, IL-6, and CCL2 triggered by LPS. Ziram 13-18 interleukin 6 Homo sapiens 165-169 33743405-11 2021 Urinary Ni, Cu, and Fe levels were associated with an increase in urinary IL-6 and a decrease in urinary cortisol among workers. Copper 12-14 interleukin 6 Homo sapiens 74-78 33743405-11 2021 Urinary Ni, Cu, and Fe levels were associated with an increase in urinary IL-6 and a decrease in urinary cortisol among workers. Iron 20-22 interleukin 6 Homo sapiens 74-78 34057209-11 2021 Long-term exposure of HGFs to nicotine or CSC significantly suppressed their cellular proliferation and migration and upregulated type I collagen, type III collagen, interleukin (IL)-6, IL-8, p16, p21, and p53 mRNA expression, and IL-6 and IL-8 protein expression. Nicotine 30-38 interleukin 6 Homo sapiens 231-235 34049969-6 2021 Importantly, plasma IL-6 and C-reactive protein (CRP) levels positively correlated with mitochondrial mass and negatively correlated with fatty acid uptake in T cells from COVID-19 patients. Fatty Acids 138-148 interleukin 6 Homo sapiens 20-24 33950864-6 2021 We found an inverse correlation between serum sodium and IL-6, whereas a direct correlation between serum sodium and PaO2/FiO2 ratio was observed. Sodium 46-52 interleukin 6 Homo sapiens 57-61 34052845-8 2021 In vivo, 3-MA and LY294002 repressed Ti particle-stimulated osteolysis and osteoclastogenesis and reduced expression of the pro-inflammatory factors TNF-alpha, IL-1beta, and IL-6. 3-methyladenine 9-13 interleukin 6 Homo sapiens 174-178 34050537-5 2022 Particles comprising high copper (Cu) and zinc (Zn) content activated human endothelial cells via a non-ROS-mediated mechanism that triggered immune activation (IL-8, GM-CSF), leukocyte adhesion to the endothelium (soluble intercellular adhesion molecule 1 (sICAM-1)), and secretion of regulators of the acute-phase protein synthesis (interleukin 6 (IL-6)). Zinc 48-50 interleukin 6 Homo sapiens 335-348 34050537-5 2022 Particles comprising high copper (Cu) and zinc (Zn) content activated human endothelial cells via a non-ROS-mediated mechanism that triggered immune activation (IL-8, GM-CSF), leukocyte adhesion to the endothelium (soluble intercellular adhesion molecule 1 (sICAM-1)), and secretion of regulators of the acute-phase protein synthesis (interleukin 6 (IL-6)). Zinc 48-50 interleukin 6 Homo sapiens 350-354 34052462-0 2021 The JAK Inhibitor Tofacitinib Inhibits Structural Damage in Osteoarthritis by Modulating JAK1/TNF-alpha/IL-6 Signaling Through Mir-149-5p. tofacitinib 18-29 interleukin 6 Homo sapiens 104-108 34052462-6 2021 Tofacitinib-treated C20A4 and C28/I2 cells had a significantly lower expression of JAK/IL-6/TNF-alpha and an increased level of miR-149-5p. tofacitinib 0-11 interleukin 6 Homo sapiens 87-91 34052462-7 2021 Notably, tofacitinib treatment reduced AC hypertrophy and secretion of RANKL and IL-6. tofacitinib 9-20 interleukin 6 Homo sapiens 81-85 34006909-9 2021 The integration of metabolic and immune data indicated a molecular signature constituted by IL-6, IL1-ra, DMG, CCL4, Ile, Gly and IL-8, which could discriminate patients and healthy subjects and could represent a candidate tool in the diagnosis of new-onset psoriasis. Glycine 122-125 interleukin 6 Homo sapiens 92-96 34031932-2 2021 Retinoic acid-inducible gene (RIG)-I-like receptors (RLR), including melanoma differentiation-associated protein 5 (MDA5) and RIG-I, recognize the double-strand (ds) virus RNA and induce the production of Type I interferon (Type I IFN) as well as pro-inflammatory cytokines like Interleukin (IL)-6. Tretinoin 0-13 interleukin 6 Homo sapiens 279-297 34020444-7 2021 RESULTS: We observed moderate positive associations of circulating choline, carnitine, and DMG with creatinine [beta (95% CI): 0.136 (0.084, 0.188), 0.106 (0.045, 0.168), and 0.128 (0.087, 0.169), respectively, for each SD increase in biomarkers on the log scale], carnitine with triglycerides (beta = 0.076; 95% CI: 0.042, 0.109), homocysteine (beta = 0.064; 95% CI: 0.033, 0.095), and LDL cholesterol (beta = 0.055; 95% CI: 0.013, 0.096), DMG with homocysteine (beta = 0.068; 95% CI: 0.023, 0.114), insulin (beta = 0.068; 95% CI: 0.043, 0.093), and IL-6 (beta = 0.060; 95% CI: 0.027, 0.094), but moderate inverse associations of betaine with triglycerides (beta = -0.146; 95% CI: -0.188, -0.104), insulin (beta = -0.106; 95% CI: -0.130, -0.082), homocysteine (beta = -0.097; 95% CI: -0.149, -0.045), and total cholesterol (beta = -0.074; 95% CI: -0.102, -0.047). Creatinine 100-110 interleukin 6 Homo sapiens 551-555 34052691-7 2021 RESULTS: There was a significant reduction in TNF-alpha concentration (F [3, 20.42] = 4.96, p = 0.01, eta2p = 0.42) post alcohol administration, compared to baseline concentrations, and a significant increase in IL-6 concentrations (F [3, 27.81] = 9.06, p < 0.001, eta2p = 0.49) post alcohol administration, compared to baseline. Alcohols 121-128 interleukin 6 Homo sapiens 212-216 33165509-8 2021 Tofacitinib induced stronger inhibition of inflammatory cytokine release (IL-6, TNFalpha, IL-12, IL-23) in UC compared with CD monocytes. tofacitinib 0-11 interleukin 6 Homo sapiens 74-78 34055120-12 2021 In addition, serum levels of vitamin D and circulated plasma markers of inflammation and bone metabolism such as CRP, IL-6, TNF-alpha, s-Ca, s-BAP, s-OC, and s-NTX were significantly reduced in severe LBP cases compared to those with minimal LBP scores. Vitamin D 29-38 interleukin 6 Homo sapiens 118-122 33722593-0 2021 COVID-19 and IL-6: Why Vitamin D (probably) helps but tocilizumab might not. Vitamin D 23-32 interleukin 6 Homo sapiens 13-17 33722593-2 2021 Could Vitamin D, which modulates IL-6, be more effective than currently deployed IL-6 antagonists, including tocilizumab, thereby presenting a useful therapeutic option in COVID-19? Vitamin D 6-15 interleukin 6 Homo sapiens 33-37 33722593-5 2021 While tocilizumab non-selectively blocks both anti-inflammatory and pro-inflammatory actions of IL-6, Vitamin D lowers immune cell IL-6 production, potentially reducing pro-inflammatory effects, but does not specifically target IL-6 receptors, avoiding any deleterious effect on the anti-inflammatory actions of IL-6. Vitamin D 102-111 interleukin 6 Homo sapiens 131-135 33722593-5 2021 While tocilizumab non-selectively blocks both anti-inflammatory and pro-inflammatory actions of IL-6, Vitamin D lowers immune cell IL-6 production, potentially reducing pro-inflammatory effects, but does not specifically target IL-6 receptors, avoiding any deleterious effect on the anti-inflammatory actions of IL-6. Vitamin D 102-111 interleukin 6 Homo sapiens 131-135 33722593-6 2021 Vitamin D may have advantages over tocilizumab as an IL-6 immunomodulator, and, given that it is safe if administered under clinical supervision, there is a strong rationale for its use. Vitamin D 0-9 interleukin 6 Homo sapiens 53-57 33713693-10 2021 Ethanol exposure decreased cell viability and the expression of BDNF and increased the cell apoptosis rate and the expression of BAX, cleaved caspase-3, IL-1beta and IL-6. Ethanol 0-7 interleukin 6 Homo sapiens 166-170 33979248-7 2021 Importantly, there was good responsiveness to steroids and the TNF inhibitor.Conclusion: Unclassified intraocular inflammation might include a new category of disease with unilateral pan-uveitis with good response to steroid therapy and extremely high vitreous IL-6 values. Steroids 46-54 interleukin 6 Homo sapiens 261-265 34055794-9 2021 In contrast, the ACh-alpha7nAChR axis in ILC2 diminishes the synthesis of TNF-alpha, IL-1, and IL-6, attenuating lung inflammation whereas, VIP-VPAC1, N/OFQ-NOP axes cause bronchodilation and anti-inflammatory effects. Acetylcholine 17-20 interleukin 6 Homo sapiens 95-99 33979248-7 2021 Importantly, there was good responsiveness to steroids and the TNF inhibitor.Conclusion: Unclassified intraocular inflammation might include a new category of disease with unilateral pan-uveitis with good response to steroid therapy and extremely high vitreous IL-6 values. Steroids 46-53 interleukin 6 Homo sapiens 261-265 34012440-8 2021 Results: Iron impaired microglial function in vitro regarding phagocytosis and markers of inflammation; this was regulated by clozapine, reflected in reduced release of IL-6 and normalization of neuronal phagocytosis. Iron 9-13 interleukin 6 Homo sapiens 169-173 33959974-5 2021 PPE36 inhibited the polarization of THP-1 cell differentiation to M1 macrophages, reduced mitochondrial dehydrogenase activity, inhibited the expression of CD16, and repressed the expression of pro-inflammatory cytokines IL-6 and TNF-alpha, as well as chemokines CXCL9, CXCL10, CCL3, and CCL5. ppe36 0-5 interleukin 6 Homo sapiens 221-225 33421881-8 2021 Arginine and vitamin B6 supplemented into cell culture effectively decreased the levels of IL-6 and IL-8. Arginine 0-8 interleukin 6 Homo sapiens 91-95 33957967-11 2021 The autophagy promoter (3-MA) and inhibitor (rapamycin) significantly decreased or increased the expression of TNF-alpha, IL-6, and IL-1beta by DCs. Sirolimus 45-54 interleukin 6 Homo sapiens 122-126 32697835-6 2021 E2 levels were negatively correlated with IL-2R, IL-6, IL-8 and TNFalpha in luteal phase (Pearson Correlation=-0.592, -0.558, -0.545, -0.623; p=0.033, 0.048, 0.054, 0.023), and with C3 in follicular phase (Pearson Correlation=-0.651; p=0.030). Estradiol 0-2 interleukin 6 Homo sapiens 49-53 33582286-2 2021 In a transgenic zebrafish system with chronic systemic overexpression of human IL6 (IL6-OE) we show that inflammation can cause intra-hepatic accumulation of triglycerides. Triglycerides 158-171 interleukin 6 Homo sapiens 79-82 33578236-9 2021 In animal trials, Tanshinone I and Tanshinone IIA/B significantly reduced MPO activity, and the levels of TNF-alpha, IL-1beta and IL-6 in serum and mammary gland tissues. tanshinone 18-30 interleukin 6 Homo sapiens 130-134 33578236-9 2021 In animal trials, Tanshinone I and Tanshinone IIA/B significantly reduced MPO activity, and the levels of TNF-alpha, IL-1beta and IL-6 in serum and mammary gland tissues. tanshinone 35-49 interleukin 6 Homo sapiens 130-134 33582286-2 2021 In a transgenic zebrafish system with chronic systemic overexpression of human IL6 (IL6-OE) we show that inflammation can cause intra-hepatic accumulation of triglycerides. Triglycerides 158-171 interleukin 6 Homo sapiens 84-87 33582286-3 2021 Transcriptomics and proteomics analysis of the IL6-OE liver revealed a deregulation of glycolysis/gluconeogenesis pathway, especially a striking down regulation of the glycolytic enzyme aldolase b. Metabolomics analysis by mass spectrometry showed accumulation of hexose monophosphates and their derivatives, which can act as precursors for triglyceride synthesis. Triglycerides 341-353 interleukin 6 Homo sapiens 47-50 33378113-11 2021 CONCLUSIONS: Results of this preliminary study suggest that increases in circulating IL-6, perhaps due to testosterone inhibition, may play a role in fatigue secondary to receipt of ADT. Testosterone 106-118 interleukin 6 Homo sapiens 85-89 33622713-2 2021 The tryptophan catabolizing enzyme IDO1 (indoleamine 2,3-dioxygenase) has been implicated in promoting neovascularization through its positioning as a key regulatory node between the inflammatory cytokines IFNgamma and IL6. Tryptophan 4-14 interleukin 6 Homo sapiens 219-222 33932089-16 2021 Alcohol appears to suppress pro-inflammatory IL-12 and IL-6, whereas patients without alcohol have greater levels of anti-inflammatory IL-10 expressed at injury and may better regulate anti-inflammatory pathways. Alcohols 0-7 interleukin 6 Homo sapiens 55-59 33443628-13 2021 Increased IL-6 concentration in the cell culture supernatant and cell lysate indicate a secondary inflammatory response of HCFs and KC-HCFs to riboflavin UV-A illumination. Riboflavin 143-153 interleukin 6 Homo sapiens 10-14 33971617-13 2021 Plasma glucose was strongly correlated with hsCRP (p<0.001) and IL-6 (p<0.0001). Glucose 7-14 interleukin 6 Homo sapiens 64-68 33847390-13 2021 Moreover, histological and ultrastructural improvements were seen in the rat population treated with BPA and Se, whereas ALT and AST levels were lowered and malondialdehyde (MDA), glutathione peroxidase (GPx), human C reactive protein (hCRP), and the serum levels of interleukin-6 (IL-6) were significantly modulated. bisphenol A 101-104 interleukin 6 Homo sapiens 267-280 32955700-8 2021 Subsequent multivariate logistic regression analysis revealed that among these inflammatory cytokines, only IL-6 (P = 0.019) independently predicted higher ASAS 20 response to celecoxib at W12, and it had a fair value for predicting ASAS 20 response to celecoxib at W12 (area under the curve: 0.666, 95% confidence interval: 0.561-0.771) by receiver-operating characteristic curve analysis. Aspirin 156-160 interleukin 6 Homo sapiens 108-112 33847390-13 2021 Moreover, histological and ultrastructural improvements were seen in the rat population treated with BPA and Se, whereas ALT and AST levels were lowered and malondialdehyde (MDA), glutathione peroxidase (GPx), human C reactive protein (hCRP), and the serum levels of interleukin-6 (IL-6) were significantly modulated. bisphenol A 101-104 interleukin 6 Homo sapiens 282-286 33301930-9 2021 CONCLUSIONS: Control of bone turnover, in part through the inhibition of the IL-6 axis, is observed during tocilizumab and subsequent steroid treatment of PMR. Steroids 134-141 interleukin 6 Homo sapiens 77-81 33219895-8 2021 Furthermore, we detected elevated levels of IL-8, IL-6, and TNF-alpha in EH patients could activate platelets/ECs and induce elevated PS exposure on their membranes. Phosphatidylserines 134-136 interleukin 6 Homo sapiens 50-54 33968948-7 2021 Besides, heparin can also modulate immune responses, alleviating TNF-alpha-mediated inflammation, impairing IL-6 production and secretion, and binding to complement proteins and leukotriene B4 (LTB4). Heparin 9-16 interleukin 6 Homo sapiens 108-112 33995051-10 2021 The 16 postoperative interventions revealed that the effect of DHI at 14 days was better than that at 7 and 10 days for hs-CRP (p = 0.013), the 10-days treatment produced better results for CK-MB than for the other treatments (p < 0.001) and a dosage of 30 ml proved most effective for IL-6 (p < 0.001). dehydrosoyasaponin I 63-66 interleukin 6 Homo sapiens 286-290 33899926-5 2021 Tofacitinib down-regulated inflammatory cytokines by stimulated B (IL-6 and TNF-alpha) and T (IFN-gamma, IL-17, or TNF-alpha) cells in the short term while a significant reduction of IL-17 and IL-6 levels in PBMC supernatant was also observed. tofacitinib 0-11 interleukin 6 Homo sapiens 67-71 33899926-5 2021 Tofacitinib down-regulated inflammatory cytokines by stimulated B (IL-6 and TNF-alpha) and T (IFN-gamma, IL-17, or TNF-alpha) cells in the short term while a significant reduction of IL-17 and IL-6 levels in PBMC supernatant was also observed. tofacitinib 0-11 interleukin 6 Homo sapiens 193-197 32826068-6 2021 In this article, we review how high dose steroids and most importantly apheresis and modern therapies implicating B cell depletion, inhibition of complement and IL-6 reception are effective to change its natural history. Steroids 41-49 interleukin 6 Homo sapiens 161-165 33984751-10 2021 Interaction network construction and topological analysis yielded 60 hub targets, of which 18 were major hub targets, among which IL-6, IL-8, TNF, PI3K, MAPK, and NF-kappaB (RELA) are the most important in LYT"s treatment of AAD-induced MetS. L-2-Aminoadipic acid 225-228 interleukin 6 Homo sapiens 130-134 33925189-7 2021 In vitro genetic manipulation of IL-6 production by primary CAFs isolated from human CCA showed that IL-6 impairs the autophagy-associated apoptotic response to 5-FU in human CCA cells. Fluorouracil 161-165 interleukin 6 Homo sapiens 33-37 33925189-7 2021 In vitro genetic manipulation of IL-6 production by primary CAFs isolated from human CCA showed that IL-6 impairs the autophagy-associated apoptotic response to 5-FU in human CCA cells. Fluorouracil 161-165 interleukin 6 Homo sapiens 101-105 33890506-8 2021 Higher levels of serum IL-6 were observed in patients with vitamin D deficiency (P = 0.022). Vitamin D 59-68 interleukin 6 Homo sapiens 23-27 33890506-12 2021 CONCLUSION: Vitamin D deficiency in knee OA seems to be associated with a higher release of IL-6. Vitamin D 12-21 interleukin 6 Homo sapiens 92-96 33890506-13 2021 Therefore, vitamin D supplementation could reduce the disease burden by controlling the IL-6 release. Vitamin D 11-20 interleukin 6 Homo sapiens 88-92 33891717-16 2021 GSEA showed that these genes are mainly related to "inflammatory response", "complement", "interferon-alpha response", "IL6/JAK/STAT3 signaling", "TGF-beta signaling", "IL2/STAT5 signaling" and "TNF-alpha signaling via NF-kappaB". gsea 0-4 interleukin 6 Homo sapiens 120-123 33997590-9 2021 IL-6 showed a significant positive correlation with insulin sensitivity and significant negative correlation with insulin resistance and serum glutamate pyruvate transaminase. Glutamic Acid 143-152 interleukin 6 Homo sapiens 0-4 33968024-0 2021 Bile Acids Elevated in Chronic Periaortitis Could Activate Farnesoid-X-Receptor to Suppress IL-6 Production by Macrophages. Bile Acids and Salts 0-10 interleukin 6 Homo sapiens 92-96 33885657-0 2021 Rapid, highly sensitive and quantitative detection of interleukin 6 based on SERS magnetic immunoassay. Serine 77-81 interleukin 6 Homo sapiens 54-67 33885657-3 2021 We have developed a method based on SERS for the rapid and quantitative detection of IL-6. Serine 36-40 interleukin 6 Homo sapiens 85-89 33968024-8 2021 Thus, bile acids, especially CDCA, may operate to damp inflammation via FXR-mediated downregulation of IL-6 in mononuclear cells and provide a protective mechanism for CP patients. Bile Acids and Salts 6-16 interleukin 6 Homo sapiens 103-107 33959001-11 2021 In MSCs, atorvastatin and aspirin combination reduced the release of pro-inflammatory cytokines such as IL-6, IL-8, MCP-1 and IFN-gamma. Atorvastatin 9-21 interleukin 6 Homo sapiens 104-108 33919169-1 2021 Here, we report on the role of haptoglobin (Hp), whose expression depends on the synthesis of interleukin 6 (IL-6), related to the pathogenesis of multiple sclerosis (MS), as a possible marker of muscle improvement achieved after treatment with the polyphenol epigallocatechin gallate (EGCG) and an increase in the ketone body beta-hydroxybutyrate (BHB) in the blood. 3-Hydroxybutyric Acid 327-347 interleukin 6 Homo sapiens 109-113 33919169-1 2021 Here, we report on the role of haptoglobin (Hp), whose expression depends on the synthesis of interleukin 6 (IL-6), related to the pathogenesis of multiple sclerosis (MS), as a possible marker of muscle improvement achieved after treatment with the polyphenol epigallocatechin gallate (EGCG) and an increase in the ketone body beta-hydroxybutyrate (BHB) in the blood. 3-Hydroxybutyric Acid 349-352 interleukin 6 Homo sapiens 109-113 33959001-11 2021 In MSCs, atorvastatin and aspirin combination reduced the release of pro-inflammatory cytokines such as IL-6, IL-8, MCP-1 and IFN-gamma. Aspirin 26-33 interleukin 6 Homo sapiens 104-108 33924229-6 2021 The analysis showed that IL-6 is significantly correlated with glucose (p = 0.001) and BMI value (p = 0.031). Glucose 63-70 interleukin 6 Homo sapiens 25-29 33959001-12 2021 Atorvastatin alone reduced the release of IL-6, IL-8 and MCP-1 from co-cultures of stroke monocytes and MSCs. Atorvastatin 0-12 interleukin 6 Homo sapiens 42-46 33959001-13 2021 Combination of atorvastatin and aspirin had additive effect on reducing the secretion of IL-6 from co-cultures of stroke Mo and MSCs. Atorvastatin 15-27 interleukin 6 Homo sapiens 89-93 33959001-13 2021 Combination of atorvastatin and aspirin had additive effect on reducing the secretion of IL-6 from co-cultures of stroke Mo and MSCs. Aspirin 32-39 interleukin 6 Homo sapiens 89-93 33849511-13 2021 Salivary testosterone was positively correlated with TNF-alpha in the control group (rs = 0.41, p = 0.0321), while in the study group, total testosterone (TT) was positively correlated with IL-6 (rs = 0.37, p = 0.0400) and free androgen index (FAI) with TNF-alpha (rs = 0.36, p = 0.0491). Testosterone 141-153 interleukin 6 Homo sapiens 190-194 33876259-0 2021 Ibuprofen taken before exercise blunts the IL-6 response in older adults but does not alter bone alkaline phosphatase or c-telopeptide. Ibuprofen 0-9 interleukin 6 Homo sapiens 43-47 33935833-5 2021 In the 31 adolescents with usable cytokine and Glu data, we found that IL-6 was significantly positively associated with dorsal ACC Glu (beta = 0.466 +- 0.199, p = 0.029). Glutamic Acid 47-50 interleukin 6 Homo sapiens 71-75 33935833-5 2021 In the 31 adolescents with usable cytokine and Glu data, we found that IL-6 was significantly positively associated with dorsal ACC Glu (beta = 0.466 +- 0.199, p = 0.029). Glutamic Acid 132-135 interleukin 6 Homo sapiens 71-75 33935833-6 2021 Of the 16 participants who had usable Asc data, we found that at higher levels of dorsal ACC Asc, there was a negative association between IL-6 and Glu (interaction effect: beta = -0.906 +- 0.433, p = 0.034). Glutamic Acid 148-151 interleukin 6 Homo sapiens 139-143 33571577-7 2021 Moreover, 24-hour treatment with the synthetic glucocorticoid dexamethasone prevented the effects of LPS stimulation on IL-6, StAR and DAX-1 mRNA in ATC7 cells co-cultured with THP1 cells. Dexamethasone 62-75 interleukin 6 Homo sapiens 120-124 33871355-9 2021 Partial inhibition of JAK activation by sub-saturating doses of Tofacitinib specifically lowered the levels of STAT1 activation by IL-6. tofacitinib 64-75 interleukin 6 Homo sapiens 131-135 33953685-13 2021 UDP stimulated cell proliferation, migration and IL-6 secretion in RA FLSs and inhibited their apoptosis in culture, and MRS2578 inhibited these effects of UDP. Uridine Diphosphate 0-3 interleukin 6 Homo sapiens 49-53 33861386-14 2022 In pSS group, but not in controls, median IL-6 levels in supernatant were less in curcumin-treated as compared to PHA-alone subset [5.5 (0.7-1.3) vs 18.3 (12-32) ng/ml; p = 0.04]. Curcumin 82-90 interleukin 6 Homo sapiens 42-46 33861386-15 2022 mRNA expression levels of IL-6 and IL-1beta were lower in curcumin-treated samples as compared to PHA alone, both amongst pSS and control groups (p = 0.0009 and p = 0.04, respectively). Curcumin 58-66 interleukin 6 Homo sapiens 26-30 33861386-17 2022 In conclusion, curcumin reduced secretion of IL-6 levels by salivary gland tissue of patients with pSS. Curcumin 15-23 interleukin 6 Homo sapiens 45-49 33861386-18 2022 Curcumin also suppressed PHA-induced mRNA expression levels of IL-6 and IL-1beta in MSG tissue of patients with pSS and controls. Curcumin 0-8 interleukin 6 Homo sapiens 63-67 33610598-7 2021 The results indicated that heparin-iron has significantly reduced anticoagulant activity in vitro and in vivo, strongly decreases hepcidin mRNA and IL-6 induced high level of secreted hepcidin in HepG2 cell. Heparin 27-34 interleukin 6 Homo sapiens 148-152 33610598-7 2021 The results indicated that heparin-iron has significantly reduced anticoagulant activity in vitro and in vivo, strongly decreases hepcidin mRNA and IL-6 induced high level of secreted hepcidin in HepG2 cell. Iron 35-39 interleukin 6 Homo sapiens 148-152 33216905-0 2021 Tofacitinib counteracts IL-6 overexpression induced by deficient autophagy: implications in Sjogren"s syndrome. tofacitinib 0-11 interleukin 6 Homo sapiens 24-28 33912037-7 2021 In addition, 3"-SL could reverse the increased levels of inflammatory markers such as nitrite, prostaglandin E2, inducible nitric oxide synthase, cyclooxygenase-2, IL-1beta, and IL-6 in IL-1beta-stimulated chondrocytic cells. 3'-sialyllactose 13-18 interleukin 6 Homo sapiens 178-182 33918063-16 2021 Finally, melatonin diminished the phosphorylation of NF-kB and the expression of COX-2, IL-6, and TNF-alpha. Melatonin 9-18 interleukin 6 Homo sapiens 88-92 33216905-10 2021 ATG5-deficient 3D-acini reproduced the findings observed in LSG from pSS patients, showing increased expression of pro-inflammatory markers such as IL-6, which was reversed by tofacitinib. tofacitinib 176-187 interleukin 6 Homo sapiens 148-152 33832495-2 2021 The authors grouped the patients into two groups according to the vitamin D levels measured at the time of admission into the hospital and reported that lower vitamin D levels are associated with elevated D-dimer and IL-6 levels, low CD4/CD8 ratio and compromised clinical findings with elevated LIPI and SOFA scores. Vitamin D 159-168 interleukin 6 Homo sapiens 217-221 33917391-10 2021 Furthermore, we related TFR1 expression with the clinical profile of patients and showed that greater iron demand in sera-treated cells was associated with higher inflammation score (interleukin 6 (IL-6), C-reactive protein (CRP)) and advanced neurohormonal activation (NT-proBNP) in patients. Iron 102-106 interleukin 6 Homo sapiens 183-196 33917391-10 2021 Furthermore, we related TFR1 expression with the clinical profile of patients and showed that greater iron demand in sera-treated cells was associated with higher inflammation score (interleukin 6 (IL-6), C-reactive protein (CRP)) and advanced neurohormonal activation (NT-proBNP) in patients. Iron 102-106 interleukin 6 Homo sapiens 198-202 33867853-8 2021 In addition, inhibition of SIRT3 suppressed titanium particle-induced tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) expression and prevented titanium particle-induced osteolysis and bone loss in vivo. Titanium 44-52 interleukin 6 Homo sapiens 144-157 33867853-8 2021 In addition, inhibition of SIRT3 suppressed titanium particle-induced tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) expression and prevented titanium particle-induced osteolysis and bone loss in vivo. Titanium 44-52 interleukin 6 Homo sapiens 159-163 33556340-0 2021 TLR4/IL-6/IRF1 signaling regulates androgen receptor expression: A potential therapeutic target to overcome taxol resistance in ovarian cancer. Paclitaxel 108-113 interleukin 6 Homo sapiens 5-9 33918207-7 2021 Numerous in vitro and in vivo studies show that curcumin may interact with many cellular targets (NF-kappaB, JAKs/STATs, MAPKs, TNF-gamma, IL-6, PPARgamma, and TRPV1) and effectively reduce the progression of IBD with promising results. Curcumin 48-56 interleukin 6 Homo sapiens 139-143 33813381-9 2021 IL-6 production was increased following treatment with CDDP, but treatment with EPA decreased IL-6 levels. Cisplatin 55-59 interleukin 6 Homo sapiens 0-4 33583045-10 2021 Our network meta-analysis suggests that EtOH exposure may augment the effects of SARS-CoV-2 infection on hepatic fibrosis signaling pathway, cellular metabolism and homeostasis, inflammation, and neuroinflammation, and that EtOH may enhance the activity of key meditators including cytokines, such as IL1beta, IL6, and TNF, and transcription factors, such as JUN and STAT, while inhibiting the activity of anti-inflammatory mediators including glucocorticoid receptor. Ethanol 40-44 interleukin 6 Homo sapiens 310-313 33556340-6 2021 Furthermore, expression of AR and IL-6 is downregulated in TLR4-knockdown, taxol-resistant cells. Paclitaxel 75-80 interleukin 6 Homo sapiens 34-38 33556340-8 2021 On the other hand, nuclear translocation of AR is induced by IL-6 treatment, whereas knockdown of endogenous IL-6 reduces AR and TLR4 expression in taxol-resistant ovarian cancer cells. Paclitaxel 148-153 interleukin 6 Homo sapiens 109-113 33556340-4 2021 Based on transcriptomic analysis, we show that IL-6 functions as a hub gene among the upregulated genes in taxol-treated TLR4-overexpressing ovarian cancer cells. Paclitaxel 107-112 interleukin 6 Homo sapiens 47-51 33556340-11 2021 Moreover, analysis of clinical samples indicates that high IL-6 expression correlates with poor progression-free survival in ovarian cancer patients treated with taxol. Paclitaxel 162-167 interleukin 6 Homo sapiens 59-63 33556340-12 2021 Overall, our findings indicate that the TLR4/IL-6/IRF1 signaling axis represents a potential therapeutic target to overcome AR-based taxol resistance in ovarian cancer. Paclitaxel 133-138 interleukin 6 Homo sapiens 45-49 33508533-6 2021 Furthermore, Cd exposure upregulated the expression levels of TNF-alpha, IL-1beta and IL-6 in pancreatic beta-cells and elevated the TNF-alpha, IL1-beta and IL-6 levels in the serum and pancreas. Cadmium 13-15 interleukin 6 Homo sapiens 86-90 33508533-6 2021 Furthermore, Cd exposure upregulated the expression levels of TNF-alpha, IL-1beta and IL-6 in pancreatic beta-cells and elevated the TNF-alpha, IL1-beta and IL-6 levels in the serum and pancreas. Cadmium 13-15 interleukin 6 Homo sapiens 157-161 33021119-0 2021 Pyrvinium pamoate induces in-vitro suppression of IL-6 and IL-8 produced by human endometriotic stromal cells. pyrvinium 0-17 interleukin 6 Homo sapiens 50-54 33916085-6 2021 Relative to the control day, there were significant increases in saliva IL-6 and IL-10 concentrations on the post-alcohol day. Alcohols 114-121 interleukin 6 Homo sapiens 72-76 33021119-7 2021 Our Findings showed that pyrvinium pamoate suppresses the mRNA gene expression and secretion of IL-6 and IL-8 in human endometriotic stromal cells. pyrvinium 25-42 interleukin 6 Homo sapiens 96-100 33180271-0 2021 Correction to: Nitric Oxide/Cyclic GMP-Dependent Calcium Signalling Mediates IL-6- and TNF-alpha-Induced Expression of Glial Fibrillary Acid Protein. Nitric Oxide 15-27 interleukin 6 Homo sapiens 77-81 33501684-8 2021 Tomentosin further inhibited the inflammatory transcription factors such as nuclear factor kappaB (NF-kappaB), tumor necrosis factor alpha, interleukin 1beta (IL-1beta), and IL-6. tomentosin 0-10 interleukin 6 Homo sapiens 174-178 32964397-0 2021 Nitric Oxide/Cyclic GMP-Dependent Calcium Signalling Mediates IL-6- and TNF-alpha-Induced Expression of Glial Fibrillary Acid Protein. Nitric Oxide 0-12 interleukin 6 Homo sapiens 62-66 32964397-0 2021 Nitric Oxide/Cyclic GMP-Dependent Calcium Signalling Mediates IL-6- and TNF-alpha-Induced Expression of Glial Fibrillary Acid Protein. Cyclic GMP 13-23 interleukin 6 Homo sapiens 62-66 33180271-0 2021 Correction to: Nitric Oxide/Cyclic GMP-Dependent Calcium Signalling Mediates IL-6- and TNF-alpha-Induced Expression of Glial Fibrillary Acid Protein. Cyclic GMP 28-38 interleukin 6 Homo sapiens 77-81 32964397-0 2021 Nitric Oxide/Cyclic GMP-Dependent Calcium Signalling Mediates IL-6- and TNF-alpha-Induced Expression of Glial Fibrillary Acid Protein. Calcium 34-41 interleukin 6 Homo sapiens 62-66 32964397-3 2021 In human glioblastoma astrocytoma U-373 MG cells, IL-6 and TNF-alpha, but not IL-4 or IL-10, increased iNOS, cGMP, [Ca2+]i and GFAP expression. Cyclic GMP 109-113 interleukin 6 Homo sapiens 50-54 33180271-0 2021 Correction to: Nitric Oxide/Cyclic GMP-Dependent Calcium Signalling Mediates IL-6- and TNF-alpha-Induced Expression of Glial Fibrillary Acid Protein. Calcium 49-56 interleukin 6 Homo sapiens 77-81 33387302-8 2021 Treatment of cortical astrocytes with conditioned medium (CM) from ethanol exposed ECs, upregulated astrocyte"s expression of GFAP, Cx43, and Lipocalin-2 genes, as well as the pro-inflammatory genes, IL-1beta, IL-6, and TNF-alpha, which was accompanied by NF-kappa B protein nuclear accumulation. Ethanol 67-74 interleukin 6 Homo sapiens 210-214 33549904-11 2021 We further found that increase in miR-126-3p expression not only suppressed hypoxia-induced increases in IL-6 and TNFalpha production, but also attenuated hypoxia-induced increases in HIF1alpha expression and 8-Isoprostane production in trophoblasts cultured under hypoxic condition. 8-epi-prostaglandin F2alpha 209-222 interleukin 6 Homo sapiens 105-109 33859989-8 2021 Furthermore, the serum and urine Zn concentrations negatively correlated with the serum IL-6 and IL-8 concentrations. Zinc 33-35 interleukin 6 Homo sapiens 88-92 33711835-0 2021 Simultaneous Quantitative Detection of IL-6 and PCT Using SERS magnetic immunoassay with sandwich structure. Serine 58-62 interleukin 6 Homo sapiens 39-43 33711835-4 2021 Therefore, we have developed a SERS-based magnetic immunoassay method that uses the principle of sandwich method to quantitatively detect Interleukin 6 (IL-6) and Procalcitonin (PCT). Serine 31-35 interleukin 6 Homo sapiens 138-151 33711835-4 2021 Therefore, we have developed a SERS-based magnetic immunoassay method that uses the principle of sandwich method to quantitatively detect Interleukin 6 (IL-6) and Procalcitonin (PCT). Serine 31-35 interleukin 6 Homo sapiens 153-157 33482194-6 2021 IL-6 was associated with poorer task performance, independent of potential demographic and health confounders (e.g., sex, education, smoking status, alcohol intake, presence of illness symptoms, and medication intake). Alcohols 149-156 interleukin 6 Homo sapiens 0-4 33841866-9 2021 In patients with MCD and FSGS, multivariate analyses identified FSGS and the levels of Hx, Hgl or IL-6 as independent predictors of steroid resistance. Steroids 132-139 interleukin 6 Homo sapiens 98-102 33841866-11 2021 In MCD and FSGS, elevated levels of Hx, Hgl or IL-6 are independently associated with steroid resistance. Steroids 86-93 interleukin 6 Homo sapiens 47-51 33781818-4 2021 Two nanoparticle types, 200 kDa N,O-carboxymethyl chitosan-HACC (NO-CMC-HACC) and N-carboxymethyl chitosan-HACC (N-CMC-HACC), greatly promoted the expression of interleukin-6, tumor necrosis factor, and interleukin-1beta in DCs. O,N-carboxymethylchitosan 32-58 interleukin 6 Homo sapiens 161-174 33869300-8 2021 We first demonstrated that the number and function of circulating EPCs are reduced in the AAD group, which may be partly related to upregulated plasma IL-6 and IL-17. L-2-Aminoadipic acid 90-93 interleukin 6 Homo sapiens 151-155 33998893-5 2021 Relative to the LPS-activated and untreated control (M[LPS]), both 25 muM CBD and 10 muM Dex reduced expression of pro-inflammatory markers-tumor necrosis factor alpha, interleukin 1 beta, and regulated on activation, normal T cell expressed and secreted (RANTES)-as well as the pleiotropic marker interleukin-6 (IL-6). Dexamethasone 89-92 interleukin 6 Homo sapiens 298-311 33998893-5 2021 Relative to the LPS-activated and untreated control (M[LPS]), both 25 muM CBD and 10 muM Dex reduced expression of pro-inflammatory markers-tumor necrosis factor alpha, interleukin 1 beta, and regulated on activation, normal T cell expressed and secreted (RANTES)-as well as the pleiotropic marker interleukin-6 (IL-6). Dexamethasone 89-92 interleukin 6 Homo sapiens 313-317 33998893-7 2021 Dex further reduced secreted levels of monocyte chemoattractant protein-1 in addition to suppressing IL-6 and VEGF beyond treatments with CBD. Dexamethasone 0-3 interleukin 6 Homo sapiens 101-105 33760381-10 2021 In TPC-1 cells ouabain also inhibited cell migration; increased IL-6/IL-6R expression and IL-6 secretion; and diminished vimentin and SNAIL-1 expression. Ouabain 15-22 interleukin 6 Homo sapiens 64-68 33760381-10 2021 In TPC-1 cells ouabain also inhibited cell migration; increased IL-6/IL-6R expression and IL-6 secretion; and diminished vimentin and SNAIL-1 expression. Ouabain 15-22 interleukin 6 Homo sapiens 69-73 33742671-2 2021 Anti-interleukin-6 treatments show a clear benefit with a significant steroid-sparing effect, but late relapses occur after treatment discontinuation. Steroids 70-77 interleukin 6 Homo sapiens 5-18 33771682-0 2021 Interleukin-6 reverses Adriamycin resistance in nasal NK/T-cell lymphoma via downregulation of ABCC4 and inactivation of the JAK2/STAT3/NF-kappaB/P65 pathway. Doxorubicin 23-33 interleukin 6 Homo sapiens 0-13 33771682-8 2021 IL-6 significantly inhibited resistance to Adriamycin (ADM) in ADM-resistant SNK-6 cells (SNK-6/ADM). Doxorubicin 43-53 interleukin 6 Homo sapiens 0-4 33771682-8 2021 IL-6 significantly inhibited resistance to Adriamycin (ADM) in ADM-resistant SNK-6 cells (SNK-6/ADM). Doxorubicin 55-58 interleukin 6 Homo sapiens 0-4 33771682-8 2021 IL-6 significantly inhibited resistance to Adriamycin (ADM) in ADM-resistant SNK-6 cells (SNK-6/ADM). Doxorubicin 63-66 interleukin 6 Homo sapiens 0-4 33753826-8 2021 In addition, puerarin reduced the activities of aspartate aminotransferase and alkaline phosphatase, the ratio of serum aspartate aminotransferase to serum alanine aminotransferase, the number of white blood cells and neutrophils, and the plasma concentrations of interleukin-6, interleukin-8 and tumor necrosis factor-alpha, as well as protein abundances of heat shock protein-70 in PEDV-infected piglets. puerarin 13-21 interleukin 6 Homo sapiens 264-277 33712045-13 2021 IGFBP3-mediated ROS production was reduced by the NF-kappaB inhibitor BMS-345541, while exogenous IL-6 rescued the NF-kappaB-inhibited, IGFBP3-mediated ROS production. Reactive Oxygen Species 152-155 interleukin 6 Homo sapiens 98-102 33791043-8 2021 Acute and prolonged exposure to EtOH significantly reduced dose-independent IL-1beta-induced IL-6 and TNF-alpha release, as well as adhesion capacity to pretreated HepG2 cells. Ethanol 32-36 interleukin 6 Homo sapiens 93-97 33790966-13 2021 GSEA showed that interleukin-6 (IL-6)/Janus kinase (JAK)/signal transducer and activator of transcription (STAT3) signaling, interferon gamma (IFN-gamma) response, angiogenesis, and coagulation were more highly enriched in the high-risk group and that oxidative phosphorylation was more highly enriched in the low-risk group. gsea 0-4 interleukin 6 Homo sapiens 17-30 33859520-0 2021 Oral Resveratrol supplementation attenuates exercise-induced Interleukin-6 but not Oxidative Stress after a high intensity cycling challenge in adults. Resveratrol 5-16 interleukin 6 Homo sapiens 61-74 33868142-9 2021 However, the expression levels of malondialdehyde and inflammatory factors (IL-1beta, TNF-alpha, IL-6, and IL-10) were remarkably decreased after the intervention of the WF. Malondialdehyde 34-49 interleukin 6 Homo sapiens 97-101 33790966-13 2021 GSEA showed that interleukin-6 (IL-6)/Janus kinase (JAK)/signal transducer and activator of transcription (STAT3) signaling, interferon gamma (IFN-gamma) response, angiogenesis, and coagulation were more highly enriched in the high-risk group and that oxidative phosphorylation was more highly enriched in the low-risk group. gsea 0-4 interleukin 6 Homo sapiens 32-36 33777989-9 2021 Furthermore, the vitamin D status had significantly negative correlations with IL-6 (r = -0.56, P < 0.01) and TNF-alpha (r = -0.47, P < 0.01) levels. Vitamin D 17-26 interleukin 6 Homo sapiens 79-83 33428699-7 2021 With respect to planar counterparts, channeled 3D beta-TCP structures stimulate more interleukin-6 and Fibronectin production and define Connexin 43 distribution inside the cells. beta-tricalcium phosphate 50-58 interleukin 6 Homo sapiens 85-98 33777989-11 2021 Severe vitamin D deficiency status may play a role in the painful DPN pathogenesis through elevated IL-6 and TNF-alpha levels. Vitamin D 7-16 interleukin 6 Homo sapiens 100-104 33345849-8 2021 Proliferation assay and apoptosis assay were applied and proved that IL-6 enhances the chemoresistance of OvCa cells against cisplatin through the upregulation of HIF-1alpha via the STAT3 signaling in vitro. Cisplatin 125-134 interleukin 6 Homo sapiens 69-73 33345849-9 2021 The In vivo studies confirmed the effect of IL-6 in increasing the chemoresistance of OvCa cells against cisplatin through the IL-6/STAT3/HIF-1alpha loop in the animal models. Cisplatin 105-114 interleukin 6 Homo sapiens 44-48 33737851-5 2021 More importantly, nicotine in smoking has been hypothesized to downregulate Interleukin-6 (IL-6) which plays a role in COVID-19 severity and to interfere with the Angiotensin-Converting Enzyme 2 (ACE2), the receptor of SARS-CoV-2 led the scientists to experiment nicotine patch prophylactically against COVID-19. Nicotine 18-26 interleukin 6 Homo sapiens 76-89 32909045-9 2021 RESULTS: Tofacitinib corrected compromised barrier function upon PTPN2 loss in macrophages and/or IECs via normalization of (i) tight junction protein expression, (ii) excessive STAT3 signaling, and (iii) IL-6 and IL-22 secretion. tofacitinib 9-20 interleukin 6 Homo sapiens 205-209 33746945-3 2021 Our results indicated that IL-6 levels were closely related to age, sex, body temperature, oxygen saturation (SpO2) of blood, and underlying diseases. Oxygen 91-97 interleukin 6 Homo sapiens 27-31 33737851-5 2021 More importantly, nicotine in smoking has been hypothesized to downregulate Interleukin-6 (IL-6) which plays a role in COVID-19 severity and to interfere with the Angiotensin-Converting Enzyme 2 (ACE2), the receptor of SARS-CoV-2 led the scientists to experiment nicotine patch prophylactically against COVID-19. Nicotine 18-26 interleukin 6 Homo sapiens 91-95 33737851-5 2021 More importantly, nicotine in smoking has been hypothesized to downregulate Interleukin-6 (IL-6) which plays a role in COVID-19 severity and to interfere with the Angiotensin-Converting Enzyme 2 (ACE2), the receptor of SARS-CoV-2 led the scientists to experiment nicotine patch prophylactically against COVID-19. Nicotine 263-271 interleukin 6 Homo sapiens 76-89 33737851-5 2021 More importantly, nicotine in smoking has been hypothesized to downregulate Interleukin-6 (IL-6) which plays a role in COVID-19 severity and to interfere with the Angiotensin-Converting Enzyme 2 (ACE2), the receptor of SARS-CoV-2 led the scientists to experiment nicotine patch prophylactically against COVID-19. Nicotine 263-271 interleukin 6 Homo sapiens 91-95 34014157-12 2021 After curcumin treatment, the changes in CCL2 were positively associated with the changes in IL-6. Curcumin 6-14 interleukin 6 Homo sapiens 93-97 33655586-9 2021 After high glucose induction, the expression of TNF-alpha, IL-1beta, and IL-6 was increased and the expression of MCP-1, NLPR3, and ASC proteins was also increased (p < .001). Glucose 11-18 interleukin 6 Homo sapiens 73-77 33175976-12 2021 CONCLUSION: We here describe an imbalance of cTFH toward TFH 1 that may induce B cell alteration through IL-21 and IL-6 pathways and promote inflammation, contributing to the pathogenesis of SSc disease. ctfh 45-49 interleukin 6 Homo sapiens 115-119 33516376-3 2021 A novel quartz crystal microbalance (QCM) immunoassay method was presented for high sensitivity and selectivity detection of interleukin-6 (IL-6) based on gold nanoparticles functionalized sulfur-doped graphene quantum dot (AuNPs/S-GQD) and hollow ZnS-CdS nanocage (h-ZnS-CdS NC). Zinc 248-251 interleukin 6 Homo sapiens 125-138 33516376-3 2021 A novel quartz crystal microbalance (QCM) immunoassay method was presented for high sensitivity and selectivity detection of interleukin-6 (IL-6) based on gold nanoparticles functionalized sulfur-doped graphene quantum dot (AuNPs/S-GQD) and hollow ZnS-CdS nanocage (h-ZnS-CdS NC). Zinc 248-251 interleukin 6 Homo sapiens 140-144 33516376-3 2021 A novel quartz crystal microbalance (QCM) immunoassay method was presented for high sensitivity and selectivity detection of interleukin-6 (IL-6) based on gold nanoparticles functionalized sulfur-doped graphene quantum dot (AuNPs/S-GQD) and hollow ZnS-CdS nanocage (h-ZnS-CdS NC). Cadmium 252-255 interleukin 6 Homo sapiens 125-138 33516376-3 2021 A novel quartz crystal microbalance (QCM) immunoassay method was presented for high sensitivity and selectivity detection of interleukin-6 (IL-6) based on gold nanoparticles functionalized sulfur-doped graphene quantum dot (AuNPs/S-GQD) and hollow ZnS-CdS nanocage (h-ZnS-CdS NC). Cadmium 252-255 interleukin 6 Homo sapiens 140-144 33477067-0 2021 Corrigendum to "Glutathione S-transferases P1-mediated interleukin-6 in tumor-associated macrophages augments drug-resistance in MCF-7 breast cancer" [Biochem. Glutathione 16-27 interleukin 6 Homo sapiens 55-68 33388592-0 2021 SO2 derivatives induce dysfunction in human trophoblasts via inhibiting ROS/IL-6/STAT3 pathway. ros 72-75 interleukin 6 Homo sapiens 76-80 33388592-15 2021 Decreased ROS/IL-6/STAT3 levels play a role in inhibited cell viability, cell cycle arrest, apoptosis and defective motility. ros 10-13 interleukin 6 Homo sapiens 14-18 32808296-6 2021 We also found that reactive oxygen species (ROS) generation potentiated the effects of PM2.5 on IL-6 production. Reactive Oxygen Species 19-42 interleukin 6 Homo sapiens 96-100 33418245-8 2021 CoQ10 also counteracts inflammatory response mediated after radiation exposure through downregulating intestinal NF-kB expression which subsequently decreased the level of inflammatory cytokine IL-6 and the expression of COX-2. coenzyme Q10 0-5 interleukin 6 Homo sapiens 194-198 32808296-6 2021 We also found that reactive oxygen species (ROS) generation potentiated the effects of PM2.5 on IL-6 production. Reactive Oxygen Species 44-47 interleukin 6 Homo sapiens 96-100 33248335-11 2021 Increased levels of IL-4 (Th2), IL-6 (Th2) and TNF- alpha (Th1) and decreased levels of IL-2 (Th1) and IL-10 (Tregs) were observed in Cd exposed workers which is indicative of a predominant pro-inflammatory response in Cd exposed workers. Cadmium 134-136 interleukin 6 Homo sapiens 32-36 33497843-7 2021 ATP or ADP induced significantly greater production of IL-6 by HSC-2 cells. Adenosine Triphosphate 0-3 interleukin 6 Homo sapiens 55-59 33497843-7 2021 ATP or ADP induced significantly greater production of IL-6 by HSC-2 cells. Adenosine Diphosphate 7-10 interleukin 6 Homo sapiens 55-59 33497843-9 2021 ATP or ADP induced the production of IL-6 by Ca9-22 cells, but the IL-6 concentration was much lower than that in HSC-2 cells. Adenosine Triphosphate 0-3 interleukin 6 Homo sapiens 37-41 33497843-9 2021 ATP or ADP induced the production of IL-6 by Ca9-22 cells, but the IL-6 concentration was much lower than that in HSC-2 cells. Adenosine Triphosphate 0-3 interleukin 6 Homo sapiens 67-71 33497843-9 2021 ATP or ADP induced the production of IL-6 by Ca9-22 cells, but the IL-6 concentration was much lower than that in HSC-2 cells. Adenosine Diphosphate 7-10 interleukin 6 Homo sapiens 37-41 33495807-11 2021 The inhibition of SOCS3 significantly activated JAK1/STAT3 signaling, as well as enhancing the levels of TNF-alpha, IL-6 and IL-1beta, and promoting apoptosis, which was reversed by the JAK1 inhibitor Tofacitinib. tofacitinib 201-212 interleukin 6 Homo sapiens 116-120 33545432-1 2021 This study aimed to investigate the correlation between interleukin-6 (IL-6) plasma levels and treatment outcomes of selective serotonin reuptake inhibitors in patients with major depressive disorder (MDD). Serotonin 127-136 interleukin 6 Homo sapiens 56-69 33545432-1 2021 This study aimed to investigate the correlation between interleukin-6 (IL-6) plasma levels and treatment outcomes of selective serotonin reuptake inhibitors in patients with major depressive disorder (MDD). Serotonin 127-136 interleukin 6 Homo sapiens 71-75 33564118-2 2021 OBJECTIVES: To investigate the acute response of markers of lipid metabolism and interleukin (IL)-6 to dopamine infusion in people with a cervical spinal cord injury (CSCI). Dopamine 103-111 interleukin 6 Homo sapiens 81-99 33657083-6 2021 GCR was assessed as the concentration of dexamethasone required to decrease the stimulated IL-6 response by 50% (IC50), with higher concentrations indicating greater GCR. Dexamethasone 41-54 interleukin 6 Homo sapiens 91-95 33673529-7 2021 Neutralization of upstream histamine by histamine-conjugated normal human immunoglobulin has been demonstrated to inhibit the nuclear translocation of NF-kappaB, thereby preventing the release of pro-inflammatory cytokines Interleukin (IL) 1beta, TNF-alpha, and IL-6 and IL-10 in a safer manner. Histamine 27-36 interleukin 6 Homo sapiens 262-266 33673529-7 2021 Neutralization of upstream histamine by histamine-conjugated normal human immunoglobulin has been demonstrated to inhibit the nuclear translocation of NF-kappaB, thereby preventing the release of pro-inflammatory cytokines Interleukin (IL) 1beta, TNF-alpha, and IL-6 and IL-10 in a safer manner. Histamine 40-49 interleukin 6 Homo sapiens 262-266 33671522-8 2021 Furthermore, LPG displayed a stronger effect than HPG on inhibiting pro-inflammatory cytokine (TNF-alpha, IL-1beta, and IL-6) productions. 4-HYDROXYPHENYL GLYOXAL 50-53 interleukin 6 Homo sapiens 120-124 33672354-8 2021 Celecoxib and dexamethasone-loaded nanoparticles reduced the release of different inflammatory mediators (NO, TNF-alpha, IL-1beta, IL-6, PGE2 and IL-10) by lipopolysaccharide (LPS)-stimulated RAW264.7. Dexamethasone 14-27 interleukin 6 Homo sapiens 131-135 33672354-9 2021 Tenoxicam-loaded nanoparticles reduced NO and PGE2 production, although an overexpression of IL-1beta, IL-6 and IL-10 was observed. tenoxicam 0-9 interleukin 6 Homo sapiens 103-107 33632046-9 2021 Furthermore, trehalose alleviated oxidative stress in LPS-stimulated PBMCs as it reversed the altered levels of malondialdehyde and total thiols (p <= .05) and restored the activity of antioxidant enzymes glutathione peroxidase and manganese superoxide dismutase (p < .001).Conclusion: The results of this study indicated that trehalose prevented inflammation and oxidative stress in the LPS-stimulated PBMCs, providing evidence for the benefits of trehalose as a potential therapeutic agent in inflammatory conditions.Abbreviations: LPS: Lipopolysaccharide; NAC: N-Acetyl cysteine; ROS: Reactive oxygen species; IL-6: Interleukin-6; TNF-alpha: Tumor necrosis factor-alpha; SOD: Superoxide dismutase; GPx: Glutathione peroxidase; MDA: Malondialdehyde; MAPK: Mitogen-activated protein kinases; JNK: c-Jun N-terminal kinase; NF-kappaB: Nuclear factor kappa-light-chain-enhancer of activated B cells. Trehalose 13-22 interleukin 6 Homo sapiens 613-617 33632046-9 2021 Furthermore, trehalose alleviated oxidative stress in LPS-stimulated PBMCs as it reversed the altered levels of malondialdehyde and total thiols (p <= .05) and restored the activity of antioxidant enzymes glutathione peroxidase and manganese superoxide dismutase (p < .001).Conclusion: The results of this study indicated that trehalose prevented inflammation and oxidative stress in the LPS-stimulated PBMCs, providing evidence for the benefits of trehalose as a potential therapeutic agent in inflammatory conditions.Abbreviations: LPS: Lipopolysaccharide; NAC: N-Acetyl cysteine; ROS: Reactive oxygen species; IL-6: Interleukin-6; TNF-alpha: Tumor necrosis factor-alpha; SOD: Superoxide dismutase; GPx: Glutathione peroxidase; MDA: Malondialdehyde; MAPK: Mitogen-activated protein kinases; JNK: c-Jun N-terminal kinase; NF-kappaB: Nuclear factor kappa-light-chain-enhancer of activated B cells. Trehalose 13-22 interleukin 6 Homo sapiens 619-632 33620706-6 2021 IL-33 levels were undetectable in all samples and IL-6 levels were positively correlated with both seminal and sperm MDA concentrations (p < 0.01) and negatively with sperm parameters (p < 0.01). Malondialdehyde 117-120 interleukin 6 Homo sapiens 50-54 33620706-10 2021 We identified the IL-6 threshold, beyond which sperm MDA concentration rises concomitantly with the increase of IL-6 concentration. Malondialdehyde 53-56 interleukin 6 Homo sapiens 18-22 33620706-10 2021 We identified the IL-6 threshold, beyond which sperm MDA concentration rises concomitantly with the increase of IL-6 concentration. Malondialdehyde 53-56 interleukin 6 Homo sapiens 112-116 33616466-7 2021 TRP (10 muM) enhanced the production of IL-6 by the corneal epithelium and had no effect on IL-1beta and IL-10. Tryptophan 0-3 interleukin 6 Homo sapiens 40-44 33602262-7 2021 RESULTS: All the SSRIs, including paroxetine, fluoxetine, sertraline, citalopram, and fluvoxamine, show a visible cytotoxicity within the range of applied doses, and a paradoxical effect on astrocytic inflammatory responses as manifested by the promotion of inducible nitric oxide synthase (iNOS) and/or nitric oxide (NO) and the inhibition of interleukin 6 (IL-6) and/or interleukin 1beta (IL-1beta). Sertraline 58-68 interleukin 6 Homo sapiens 344-357 33337450-11 2021 The application of the STAT3 inhibitor CP690,550 reduced the production of the IL-6 family and the formation of osteoclasts both in vitro and in vivo. tofacitinib 39-44 interleukin 6 Homo sapiens 79-83 33615922-0 2021 MiR-29a Alleviates High Glucose-induced Inflammation and Mitochondrial Dysfunction via Modulation of IL-6/STAT3 in Diabetic Cataracts. Glucose 24-31 interleukin 6 Homo sapiens 101-105 33615922-1 2021 Background: This in vitro study was designed to reveal the role of miR-29a in high glucose-induced cellular injury through the modulation of IL-6/STAT3 in diabetic cataracts. Glucose 83-90 interleukin 6 Homo sapiens 141-145 33599871-6 2021 In subjects without diabetes (controls), we found an association between the G/C genotype of the -572 polymorphism and the G/C and C/C genotypes of the -597 polymorphism of IL-6 with the risk of glucose levels > 131 mg/dL. Glucose 195-202 interleukin 6 Homo sapiens 173-177 33599871-7 2021 Genotype C/C of polymorphism -174 of the IL-6 gene was associated with high triglyceride levels, and levels > 5.8% of HbA1c were associated with the G/A genotype of TNFalpha -308. Triglycerides 76-88 interleukin 6 Homo sapiens 41-45 33679753-7 2021 Also, we found a significant negative correlation between IL-6 levels during stages IIb and III, peripheral oxygen saturation (SpO2), and partial pressure of oxygen in arterial blood (PaO2), showing that IL-6 correlates with respiratory failure. Oxygen 108-114 interleukin 6 Homo sapiens 204-208 33679753-7 2021 Also, we found a significant negative correlation between IL-6 levels during stages IIb and III, peripheral oxygen saturation (SpO2), and partial pressure of oxygen in arterial blood (PaO2), showing that IL-6 correlates with respiratory failure. Oxygen 158-164 interleukin 6 Homo sapiens 58-62 33679753-7 2021 Also, we found a significant negative correlation between IL-6 levels during stages IIb and III, peripheral oxygen saturation (SpO2), and partial pressure of oxygen in arterial blood (PaO2), showing that IL-6 correlates with respiratory failure. Oxygen 158-164 interleukin 6 Homo sapiens 204-208 33602262-7 2021 RESULTS: All the SSRIs, including paroxetine, fluoxetine, sertraline, citalopram, and fluvoxamine, show a visible cytotoxicity within the range of applied doses, and a paradoxical effect on astrocytic inflammatory responses as manifested by the promotion of inducible nitric oxide synthase (iNOS) and/or nitric oxide (NO) and the inhibition of interleukin 6 (IL-6) and/or interleukin 1beta (IL-1beta). Sertraline 58-68 interleukin 6 Homo sapiens 359-363 33546705-10 2021 Furthermore, E. coli KUB-36 metabolites and individual SCFA could affect inflammatory responses in lipopolysaccharide-induced THP-1 macrophage cells since they suppressed inflammatory cytokines IL-1beta, IL-6, IL-8 and TNF-alpha well as compared to the control, whilst inducing anti-inflammatory cytokine IL-10 expression. Fatty Acids, Volatile 55-59 interleukin 6 Homo sapiens 204-208 33578781-5 2021 Moreover, the stimulatory effects of H2O2 on cellular senescence are associated with oxidative stress induction, such as excessive ROS production and NADPH consumption, telomere DNA damage induction, and upregulation of senescence-associated secretory phenotype factors (IL-1beta, IL-6, IL-8, COX-2, and TNF-alpha) as well as NF-kappaB activation, which were all blocked by FK866. Hydrogen Peroxide 37-41 interleukin 6 Homo sapiens 281-285 33507306-7 2021 Similarly, progesterone increased A20 and C/EBPbeta expression through upregulation of ER stress in NESCs, resulting in inhibition of NF-kappaB activity and IL-6 and COX2 production. Progesterone 11-23 interleukin 6 Homo sapiens 157-161 33587766-2 2021 (1) Tofacitinib is an effective oral JAK 1/3 inhibitor that can block IL-2, IL-7 and IL-6 and is reported as an option for alopecia areata treatment. tofacitinib 4-15 interleukin 6 Homo sapiens 85-89 33668579-6 2021 To remedy such challenges, in this work, we demonstrate the use of pyrene-tagged DNA aptamers (PTDA) for performing a one-step aptamer immobilization technique to implement a GFET-based biosensor for the detection of Interleukin-6 (IL-6) protein biomarker. pyrene 67-73 interleukin 6 Homo sapiens 217-230 33668579-6 2021 To remedy such challenges, in this work, we demonstrate the use of pyrene-tagged DNA aptamers (PTDA) for performing a one-step aptamer immobilization technique to implement a GFET-based biosensor for the detection of Interleukin-6 (IL-6) protein biomarker. pyrene 67-73 interleukin 6 Homo sapiens 232-236 33581965-10 2021 Also, the AGEs-elicited production of IL-6 and IL-8 was inhibited by Magnolol. magnolol 69-77 interleukin 6 Homo sapiens 38-42 33551310-0 2022 Magnolol inhibits cancer stemness and IL-6/Stat3 signaling in oral carcinomas. magnolol 0-8 interleukin 6 Homo sapiens 38-42 33568902-8 2021 In advanced correlation analyses, it was found that plasma melatonin concentration was negatively associated with the age, symptom durations, IDD disease severity and proinflammatory factors, including IL-6 and TNF-alpha concentrations (P<0.05). Melatonin 59-68 interleukin 6 Homo sapiens 202-206 33568902-9 2021 Comparing with the higher melatonin groups, significantly increased IL-6 (0.601 +- 0.085 vs 0.507 +- 0.167 pg/mL, P=0.028) and TNF-alpha (3.022 +- 0.286 vs 2.353 +- 0.641, P<0.001) were detected in the patients with lower melatonin concentration. Melatonin 26-35 interleukin 6 Homo sapiens 68-72 33557291-9 2021 Solely in the open surgery group, cortisol dynamics paralleled changes in interleukin (IL)-1beta, IL-10, IL-1ra, IL-7, IL-8 and tumor necrosis factor (TNF)-alpha but did not correlate with changes in IL-6 or interferon (IFN)-gamma at any time-point. Hydrocortisone 34-42 interleukin 6 Homo sapiens 200-204 33536381-2 2021 Cytokines, including tumor necrosis factor-alpha and interleukin-6 induce hypercortisolemia by enhancing the ACTH-independent synthesis and secretion of cortisol and by reducing cortisol breakdown. Hydrocortisone 79-87 interleukin 6 Homo sapiens 53-66 33536381-2 2021 Cytokines, including tumor necrosis factor-alpha and interleukin-6 induce hypercortisolemia by enhancing the ACTH-independent synthesis and secretion of cortisol and by reducing cortisol breakdown. Hydrocortisone 153-161 interleukin 6 Homo sapiens 53-66 33551310-8 2022 In addition, we observed that the secretion of IL-6 and phosphorylation of Stat3 were decreased in OSCC-CSCs treated with magnolol. magnolol 122-130 interleukin 6 Homo sapiens 47-51 33551310-9 2022 CONCLUSION: Our data suggest that magnolol is able to target CSCs and suppress the cancer stemness properties, at least in part, via IL-6/Stat3 signaling. magnolol 34-42 interleukin 6 Homo sapiens 133-137 33341448-5 2021 RESULTS: Across all tumour stages, vitamin D-deficient patients had the highest median levels of IL-6 (8.3 pg/mL, range 0.7-91), YKL-40 (177 ng/ml, range 25-5279) and CRP (15.5 mg/L, range 0.8-384). Vitamin D 35-44 interleukin 6 Homo sapiens 97-101 33644540-11 2021 Results: The upregulated iNOS, excessive production of NO, IL-6, and MCP-1, and activated COX-2/PGE2 signaling pathways in the astrocytes induced by isoflurane were significantly reversed by the introduction of roflumilast, in a dose-dependent manner. Roflumilast 211-222 interleukin 6 Homo sapiens 59-63 33545429-7 2021 The release of pro-inflammatory cytokines (like TNF alpha or IL-6) in response to bacterial challenge was significantly reduced, if monocytes were incubated with TGR5-activating serum bile acids from liver failure patients. Bile Acids and Salts 184-194 interleukin 6 Homo sapiens 61-65 33382511-4 2021 STAT3 is rapidly and transiently activated by tyrosine phosphorylation by a range of signalling pathways, including cytokines from the IL-6 family and growth factors, such as EGF and PDGF. Tyrosine 46-54 interleukin 6 Homo sapiens 135-139 33333394-9 2021 Serum interleukin 6 (ES = -1.02 pg/mL, 95% CI = [-2.06, 0.02], P = 0.05, I2 = 92.3%) was marginally reduced following Zn supplementation. Zinc 118-120 interleukin 6 Homo sapiens 6-19 32930970-9 2021 RESULTS: We found that IL-6 triggered stem cell-like properties in cisplatin-treated gastric cancer cells and activated STAT3, which in turn transcriptionally regulated SNHG3 expression. Cisplatin 67-76 interleukin 6 Homo sapiens 23-27 33166496-4 2021 Primary human articular chondrocyte was employed as a model for in vitro assessment of IL-6 effects in cell viability, cellular oxidative stress and iron homeostasis by MTT, MDA, ROS and Iron Colorimetric assays. Iron 149-153 interleukin 6 Homo sapiens 87-91 33166496-4 2021 Primary human articular chondrocyte was employed as a model for in vitro assessment of IL-6 effects in cell viability, cellular oxidative stress and iron homeostasis by MTT, MDA, ROS and Iron Colorimetric assays. Iron 187-191 interleukin 6 Homo sapiens 87-91 33166496-8 2021 IL-6 exposure caused cartilage cell ferroptosis by inducing cellular oxidative stress and disturbing iron homeostasis. Iron 101-105 interleukin 6 Homo sapiens 0-4 33289917-0 2021 Targeting IL-10, ZO-1 gene expression and IL-6/STAT-3 trans-signaling by a combination of atorvastatin and mesalazine to enhance anti-inflammatory effects and attenuate progression of oxazolone induced colitis. Atorvastatin 90-102 interleukin 6 Homo sapiens 42-46 33289917-0 2021 Targeting IL-10, ZO-1 gene expression and IL-6/STAT-3 trans-signaling by a combination of atorvastatin and mesalazine to enhance anti-inflammatory effects and attenuate progression of oxazolone induced colitis. Mesalamine 107-117 interleukin 6 Homo sapiens 42-46 33655086-8 2021 Second, curcumin protects from lethal pneumonia and ARDS via targeting NF-kappaB, inflammasome, IL-6 trans signal, and HMGB1 pathways. Curcumin 8-16 interleukin 6 Homo sapiens 96-100 32949301-5 2021 Cells were basally stimulated with agonists Pam2CSK4 (Pam; TLR2), polyinosinic/polycytidylic acid (Poly I:C; TLR3), and lipopolysaccharide (LPS; TLR4) for 24 h. Supernatants were evaluated with ELISA for cytokines TNFalpha, IL-6, and IL-1beta. Carbon 0-1 interleukin 6 Homo sapiens 224-228 32803665-5 2021 PGAL decreased IL-6, TNF-alpha, and IL-1beta production in human monocytes exposed to PMA without affecting cell viability. L-Lysine L-glutamate 0-4 interleukin 6 Homo sapiens 15-19 32949301-11 2021 Poly I:C induced IL-6 and TNFalpha primarily at the basal side at lower but on both sides at higher concentrations. Poly I 0-6 interleukin 6 Homo sapiens 17-21 32949301-11 2021 Poly I:C induced IL-6 and TNFalpha primarily at the basal side at lower but on both sides at higher concentrations. Carbon 7-8 interleukin 6 Homo sapiens 17-21 33416163-7 2021 Furthermore, addition of IL-6 to ZA-pretreated gefitinib-resistant cell lines abrogated the effect of ZA and restored the cellular resistance to tyrosine kinase inhibitors. Gefitinib 47-56 interleukin 6 Homo sapiens 25-29 33326919-6 2021 In this study, we indicated that DPF-6 inhibited inflammation and the expression of TNF-alpha, IL-6 and IL-1beta in liver tissues and LPS-mediated L-02 cells, concomitant with the upregulated expression of ZEB2. dpf-6 33-38 interleukin 6 Homo sapiens 95-99 33535417-8 2021 Patients with elevated IL-6 presented more frequently with anemia mellitus (64.3% vs. 41.7%; p = 0.046), atrial fibrillation (83.3% vs. 61.9% p = 0.036), dyslipidemia (76.2% vs. 58.2%; p = 0.03), higher creatinine levels (1.35 mg/dL vs. 1.08 mg/dL; p = 0.024), lower glomerular filtration rate (43.6 mL/min/m2 vs. 59.9 mL/min/m2; p = 0.007), and anemia 25% vs. 52.4% p = 0.014. Creatinine 203-213 interleukin 6 Homo sapiens 23-27 32881084-9 2021 An interplay of electrostatic, hydrophobic, hydrogen bonding and aromatic stacking interactions facilitates the formation of the hIL-6/IL-6Ralpha complex. Hydrogen 44-52 interleukin 6 Homo sapiens 129-134 32166733-8 2021 Treatment with auraptene (10-90 microM) significantly ameliorated ROS, MDA, IL-6, and TNF-alpha levels, and markedly increased GSH content, and CAT and SOD activities (p < 0.5-0.001). aurapten 15-24 interleukin 6 Homo sapiens 76-80 33277657-11 2021 CONCLUSIONS: Elevated plasma glutamate levels are associated with increased cIMT, independently of established CVD risk factors and this relationship may in part be explained by IL-6-associated subclinical inflammation. Glutamic Acid 29-38 interleukin 6 Homo sapiens 178-182 33246336-15 2021 MAIN RESULTS AND THE ROLE OF CHANCE: After 1-week grafting, the relative expression of Sod1, Hmox1 and Cat was significantly higher in the group receiving 150 mg/kg NAC (NAC150-treated group) compared to controls (P = 0.04, P = 0.03, and P = 0.01, respectively), whereas the expression levels of Tnf-alpha, Il1-beta and Il6 were reduced. nac150 170-176 interleukin 6 Homo sapiens 320-323 33146673-8 2021 Molecular docking results showed that the molecular binding affinity with IL-6 of all compounds except gamma-aminobutyric acid was < -5.0 kJ/mol, indicating the potential of numerous active compounds in TCM to directly interact with IL-6, leading to an anti-inflammation effect. gamma-Aminobutyric Acid 103-126 interleukin 6 Homo sapiens 74-78 33146673-8 2021 Molecular docking results showed that the molecular binding affinity with IL-6 of all compounds except gamma-aminobutyric acid was < -5.0 kJ/mol, indicating the potential of numerous active compounds in TCM to directly interact with IL-6, leading to an anti-inflammation effect. gamma-Aminobutyric Acid 103-126 interleukin 6 Homo sapiens 233-237 33479266-8 2021 Finally, the multi-omic integrative analysis suggested a relationship between cytokines CCL20, CX3CL1, CXCL13, IL-15, IL-22 and IL-6 with alteration in chemotaxis, as well as a link between long-chain unsaturated phospholipids and the increased fatty acid transport and prostaglandin production. Fatty Acids 245-255 interleukin 6 Homo sapiens 128-132 33481255-12 2021 r-hirudin and DTIP inhibit tumor progression through the thrombin-PAR-1-mediated RhoA and NF-kappaB signaling cascades via inhibiting the MMP9 and IL6 expression. r-hirudin 0-9 interleukin 6 Homo sapiens 147-150 33479266-8 2021 Finally, the multi-omic integrative analysis suggested a relationship between cytokines CCL20, CX3CL1, CXCL13, IL-15, IL-22 and IL-6 with alteration in chemotaxis, as well as a link between long-chain unsaturated phospholipids and the increased fatty acid transport and prostaglandin production. Prostaglandins 270-283 interleukin 6 Homo sapiens 128-132 33461297-1 2021 Recent data have shown anti-inflammatory effects for trans-resveratrol (RSV) and rosmarinic acid (RA) in various immune-competent cell models through reduction of lipopolysaccharide (LPS)-induced interleukin 6 (IL-6) release. Resveratrol 53-70 interleukin 6 Homo sapiens 196-209 33468279-13 2021 Zn could decrease IL-6 levels (SMD= -0.76 pg/ml; 95% CI: -1.28, -0.24; P= 0.004). Zinc 0-2 interleukin 6 Homo sapiens 18-22 33468279-16 2021 Conclusively, Zn supplementation can decrease the IL-6 level. Zinc 14-16 interleukin 6 Homo sapiens 50-54 33461297-1 2021 Recent data have shown anti-inflammatory effects for trans-resveratrol (RSV) and rosmarinic acid (RA) in various immune-competent cell models through reduction of lipopolysaccharide (LPS)-induced interleukin 6 (IL-6) release. Resveratrol 53-70 interleukin 6 Homo sapiens 211-215 33461297-1 2021 Recent data have shown anti-inflammatory effects for trans-resveratrol (RSV) and rosmarinic acid (RA) in various immune-competent cell models through reduction of lipopolysaccharide (LPS)-induced interleukin 6 (IL-6) release. Resveratrol 72-75 interleukin 6 Homo sapiens 196-209 33461297-1 2021 Recent data have shown anti-inflammatory effects for trans-resveratrol (RSV) and rosmarinic acid (RA) in various immune-competent cell models through reduction of lipopolysaccharide (LPS)-induced interleukin 6 (IL-6) release. rosmarinic acid 81-96 interleukin 6 Homo sapiens 196-209 33461297-1 2021 Recent data have shown anti-inflammatory effects for trans-resveratrol (RSV) and rosmarinic acid (RA) in various immune-competent cell models through reduction of lipopolysaccharide (LPS)-induced interleukin 6 (IL-6) release. rosmarinic acid 81-96 interleukin 6 Homo sapiens 211-215 33461297-6 2021 Next, the IL-6 modulatory effect of 100 muM RSV was studied in LPS-treated immune-competent HGF-1 cells. Resveratrol 44-47 interleukin 6 Homo sapiens 10-14 33461297-7 2021 After 6 h of treatment, RSV reduced the LPS-induced IL-6 gene expression and protein release by -46.2 +- 12.7 and -73.9 +- 2.99%, respectively. Resveratrol 24-27 interleukin 6 Homo sapiens 52-56 33521454-5 2021 Additionally, roflumilast prevented IL-18-induced expressions and secretions of pro-inflammatory cytokines such as IL-6, IL-8, and TNF-alpha. Roflumilast 14-25 interleukin 6 Homo sapiens 115-119 33167270-0 2021 A novel electrochemical immunosensor based on acetylene black/epoxy-substituted-polypyrrole polymer composite for the highly sensitive and selective detection of interleukin 6. Carbon 46-61 interleukin 6 Homo sapiens 162-175 33167270-3 2021 EpxS-PPyr polymer was synthesized by an esterification reaction and used to attach IL 6 receptor owing to its excellent biocompatibility and good conductivity. epxs-ppyr polymer 0-17 interleukin 6 Homo sapiens 83-87 32912961-2 2021 SARS-CoV-2 infection has been associated with the development of cytokine storm (including interleukin 6 (IL-6)), which can cause lung damage and lack of oxygen. Oxygen 154-160 interleukin 6 Homo sapiens 91-104 33446880-7 2021 Higher levels of TG n-3 polyunsaturated fatty acids (PUFAs) were associated with lower MIS (r = - 0.168) and interleukin-6 concentrations (r = - 0.115). Triglycerides 17-19 interleukin 6 Homo sapiens 110-123 32867661-1 2021 BACKGROUND: Dopamine receptor (DR) gene family play an essential role in the regulation of interleukin-6 (IL-6) production. Dopamine 12-20 interleukin 6 Homo sapiens 91-104 32867661-1 2021 BACKGROUND: Dopamine receptor (DR) gene family play an essential role in the regulation of interleukin-6 (IL-6) production. Dopamine 12-20 interleukin 6 Homo sapiens 106-110 33417619-13 2021 Lower levels of IFN-gamma, IL-6, IL-10, IL-13 and I-TAC were found in the Sp group compared with those in the Cp group. TFF2 protein, human 74-76 interleukin 6 Homo sapiens 27-31 33417619-15 2021 Meanwhile, in the Sp group, lower levels of pro-inflammatory factors IFN-gamma, IL-1beta, IL-2, IL-6, IL-7, IL-21 and TNF-alpha, in addition to higher levels of anti-inflammatory factors IL-4 and IL-5 in gingival crevicular fluid, were identified than those in the Dp group. TFF2 protein, human 18-20 interleukin 6 Homo sapiens 96-100 33413425-3 2021 Different concentrations of Dex were used to attenuate the inflammation induced by IL-1beta, and its effect was assessed via RT-PCR to detect inflammatory cytokine-related mRNA levels, including those of IKbeta-alpha, IKKbeta, IL-6, IL-8, and TNF-alpha. Dexamethasone 28-31 interleukin 6 Homo sapiens 227-231 33378989-2 2021 In theory, tocilizumab and favipiravir are considered to be reliable drugs for the treatment of COVID-19 with elevated IL-6. favipiravir 27-38 interleukin 6 Homo sapiens 119-123 32894831-8 2021 Furthermore, heparin-coated PMX-F acquired the capability to adsorb IL-6, IL-12, and tumor necrosis factor alpha. Heparin 13-20 interleukin 6 Homo sapiens 68-72 32912961-2 2021 SARS-CoV-2 infection has been associated with the development of cytokine storm (including interleukin 6 (IL-6)), which can cause lung damage and lack of oxygen. Oxygen 154-160 interleukin 6 Homo sapiens 106-110 33045281-8 2021 An IL-6-based algorithm had 98% sensitivity and 0.04 negative likelihood ratio (NLR) for 30-day oxygen requirement. Oxygen 96-102 interleukin 6 Homo sapiens 3-7 32875568-5 2021 Our data demonstrated that tumor-produced IL-6 conferred resistance to cisplatin and therapeutic vaccination. Cisplatin 71-80 interleukin 6 Homo sapiens 42-46 33390773-6 2021 Acute alcohol exposure-induced leukocyte infiltration and pro-inflammation factors, including cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6), were blocked by MLE in proportion to MLE concentration. Alcohols 6-13 interleukin 6 Homo sapiens 165-178 33390773-6 2021 Acute alcohol exposure-induced leukocyte infiltration and pro-inflammation factors, including cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6), were blocked by MLE in proportion to MLE concentration. Alcohols 6-13 interleukin 6 Homo sapiens 180-184 32077313-4 2021 PolyP-induced NF-kappaB activation and the productions of TNF-alpha and IL-6 were inhibited by aloin in HUVECs. Polyphosphates 0-5 interleukin 6 Homo sapiens 72-76 33045281-9 2021 CONCLUSION: sTREM-1 and IL-6 concentrations in COVID-19 in the ED have good predictive accuracy for intubation/mortality and oxygen requirement. Oxygen 125-131 interleukin 6 Homo sapiens 24-28 33252072-9 2021 RESULTS: reatment of HBMVECs with 30 mM glucose increased thrombin activity and expression of inflammatory proteins TNFalpha, IL-6, and MMPs 2 and 9; this elevation was reduced by the thrombin inhibitor dabigatran. Glucose 40-47 interleukin 6 Homo sapiens 126-130 33249629-8 2021 In addition, Naringenin-loaded LCNs efficiently reduced the levels of pro-inflammatory markers, namely, IL-1beta, IL-6, TNF-alpha, and IL-8. naringenin 13-23 interleukin 6 Homo sapiens 114-118 33325132-0 2021 Resveratrol treatment reduces expression of MCP-1, IL-6, IL-8 and RANTES in endometriotic stromal cells. Resveratrol 0-11 interleukin 6 Homo sapiens 51-55 33325132-3 2021 In this study, we evaluated the effects of resveratrol treatment on expression of monocyte chemotactic protein-1 (MCP-1), interleukin-6 (IL-6), IL-8, and regulated upon activation, normal T cell expressed and secreted (RANTES) in endometrial stromal cells from patients with endometriosis compared with non-endometriotic controls. Resveratrol 43-54 interleukin 6 Homo sapiens 122-135 33325132-3 2021 In this study, we evaluated the effects of resveratrol treatment on expression of monocyte chemotactic protein-1 (MCP-1), interleukin-6 (IL-6), IL-8, and regulated upon activation, normal T cell expressed and secreted (RANTES) in endometrial stromal cells from patients with endometriosis compared with non-endometriotic controls. Resveratrol 43-54 interleukin 6 Homo sapiens 137-141 33325132-5 2021 Resveratrol treatment significantly reduced gene and protein expression of MCP-1, IL-6, and IL-8 in EuESCs and EESCs compared with CESCs (P < .05-.001, P < .05-.001 and P < .05-<.01, respectively), and this reduction was more noticeable in EESCs than EuESCs (P < .05-<.001). Resveratrol 0-11 interleukin 6 Homo sapiens 82-86 33325132-7 2021 Resveratrol treatment significantly reduced the expression of MCP-1, IL-6, IL-8 and RANTES in EESCs. Resveratrol 0-11 interleukin 6 Homo sapiens 69-73 33601383-8 2021 13-cis-retinoic acid and all-trans-retinoic acid regulated IL-6 release. Tretinoin 25-48 interleukin 6 Homo sapiens 59-63 33952842-10 2021 DOX increased Interleukin-6 (IL-6) via transforming growth factor (TGF)-beta/Smad pathway. Doxorubicin 0-3 interleukin 6 Homo sapiens 14-27 33952842-10 2021 DOX increased Interleukin-6 (IL-6) via transforming growth factor (TGF)-beta/Smad pathway. Doxorubicin 0-3 interleukin 6 Homo sapiens 29-33 32674107-5 2021 METHODS: In MH7A cells, cell proliferation and the IL-6-mediated signaling pathway following administration of LMT-28 and metformin combination was analyzed through MTT assay and Western blotting. Metformin 122-131 interleukin 6 Homo sapiens 51-55 32674107-8 2021 RESULTS: Combination treatment with LMT-28 and metformin diminished proliferation of MH7A cells and IL-6-mediated gp130, STAT3, and ERK signaling more than in individual treatments. Metformin 47-56 interleukin 6 Homo sapiens 100-104 32674107-12 2021 CONCLUSION: Combination treatment with LMT-28 and metformin significantly ameliorates arthritic symptoms in CIA by suppressing Th17 differentiation and IL-6 signaling. Metformin 50-59 interleukin 6 Homo sapiens 152-156 33318918-5 2021 Both patients recovered rapidly and were successfully extubated and discharged from the hospital without need for supplemental oxygen shortly thereafter, and their clinical improvement correlated with response in interleukin-6 levels. Oxygen 127-133 interleukin 6 Homo sapiens 213-226 33017649-8 2021 Cumulative evidence from these RCTs supported the blood glucose lowering effects of metformin, in addition to promoting weight loss, ameliorating insulin resistance, and reducing pro-inflammatory markers such as interleukin-6 and tumor necrosis factor-alpha in patients with metabolic syndrome. Metformin 84-93 interleukin 6 Homo sapiens 212-225 33371832-7 2021 Furthermore, NAC decreases TNF-alpha, IL-1beta, IL-6, IL-8, IL-10, and IL-17 serum levels in patients with sepsis, severe burns, acute liver failure, or peritoneal dialysis and may also reduce cytokine storm in COVID-19. Acetylcysteine 13-16 interleukin 6 Homo sapiens 48-52 33408498-8 2020 Moreover, smoking, 5-FU induction of IL6, TNFalpha, and IL10 expression are found to be independent prognostic factors for OS (P=0.003, 0.003, 0.002, and 0.002, respectively). Fluorouracil 19-23 interleukin 6 Homo sapiens 37-40 33408498-6 2020 DFS and OS rates were reduced in patients with increased COX2, IL6, IL10, and TNFalpha expression with 5-FU therapy. Fluorouracil 103-107 interleukin 6 Homo sapiens 63-66 33355355-0 2020 Tamoxifen attenuates reactive astrocyte-induced brain metastasis and drug resistance through the IL-6/STAT3 signaling pathway. Tamoxifen 0-9 interleukin 6 Homo sapiens 97-101 33355355-7 2020 We also found that the high level of IL-6 secreted by activated astrocytes was responsible for the drug resistance of breast cancer, which could be abolished by treatment of astrocytes with tamoxifen (TAM). Tamoxifen 190-199 interleukin 6 Homo sapiens 37-41 33355355-7 2020 We also found that the high level of IL-6 secreted by activated astrocytes was responsible for the drug resistance of breast cancer, which could be abolished by treatment of astrocytes with tamoxifen (TAM). Tamoxifen 201-204 interleukin 6 Homo sapiens 37-41 33355355-8 2020 The blockage of active astrocyte-derived IL-6 by a neutralizing antibody resulted in the attenuation of drug resistance, consequently enhancing the sensitivity of breast cancer cells to doxorubicin. Doxorubicin 186-197 interleukin 6 Homo sapiens 41-45 33355355-9 2020 Furthermore, the possible involved TAM-modulated drug resistance mechanism may be associated with a decrease in IL-6 expression in astrocytes and the downregulation of MAPK and JAK2/STAT3 signaling in cancer cells. Tamoxifen 35-38 interleukin 6 Homo sapiens 112-116 33355355-10 2020 Our data suggested that TAMs might reduce drug resistance through the IL-6/JAK2/STAT3 signaling pathway, providing a possible therapy to treat brain metastasis in TNBCs, as estrogen receptor inhibitors (TAMs, etc.) Tamoxifen 24-28 interleukin 6 Homo sapiens 70-74 33351140-11 2020 Higher plasma IL-6 and hsCRP levels correlated with increased muscle and skin sodium content in the overall study population. Sodium 78-84 interleukin 6 Homo sapiens 14-18 33463132-11 2020 Our findings suggested the pathogenic role of pro-inflammatory cytokines in children with INS, of which IL-1beta, IL-6, and IL-8 were accurate biomarkers for the prediction of steroid response in these patients. Steroids 176-183 interleukin 6 Homo sapiens 114-118 33317411-8 2022 We concluded that menstrual cycle phases may alter interleukin-6 production causing a higher inflammation when progesterone levels are elevated (days 19-21). Progesterone 111-123 interleukin 6 Homo sapiens 51-64 32993961-11 2020 The up-regulated IL-6, IL-8, ROS, and NAPDH in the LPS-induced cells were reduced by miR-27a-3p mimic while inhibited by FOXO3. mir-27a-3p 85-95 interleukin 6 Homo sapiens 17-21 33317411-1 2022 The aim of the current study was to investigate iron metabolism in endurance trained women through the interleukin-6, hepcidin and iron responses to exercise along different endogenous hormonal states. Iron 48-52 interleukin 6 Homo sapiens 103-116 33218476-2 2020 Herein, an immunosensor has been developed for monitoring IL-6, which is fabricated by Au nanoparticles (Au NPs)-thionine (THI)-carboxylated multi walled carbon nanotubes (CMWCNTs) as the substrate with high conductivity. Carbon 154-160 interleukin 6 Homo sapiens 58-62 33231425-0 2020 NiCoO2@CeO2 Nanoboxes for Ultrasensitive Electrochemical Immunosensing Based on the Oxygen Evolution Reaction in a Neutral Medium: Application for Interleukin-6 Detection. Oxygen 84-90 interleukin 6 Homo sapiens 147-160 33380357-9 2021 After adjusting for age, sex, IL-6, and pre-existing comorbidities, all iron parameters were associated with the severity of COVID-19 with adjusted risk ratio of 0.42 [95% CI: 0.22-0.83], 4.38 [95% CI: 1.86-10.33], 0.19 [95% CI: 0.08-0.48], and 0.25 [95% CI: 0.10-0.58] for serum iron, ferritin, transferrin, and total iron-binding capacity, respectively. Iron 72-76 interleukin 6 Homo sapiens 30-34 33301441-6 2020 Interleukin-6-induced barrier leak was also reduced by RA. Tretinoin 55-57 interleukin 6 Homo sapiens 0-13 33363471-6 2020 Results: At a clinically relevant concentration (1 nM), roflumilast N-oxide and roflumilast consistently reduced the release of TNF-alpha, CCL2, CCL3, CCL4, CCL5 and CXCL9 (but not CXCL1, CXCL5, CXCL8 and IL-6) from human bronchial explants. Roflumilast 56-67 interleukin 6 Homo sapiens 205-209 33363471-6 2020 Results: At a clinically relevant concentration (1 nM), roflumilast N-oxide and roflumilast consistently reduced the release of TNF-alpha, CCL2, CCL3, CCL4, CCL5 and CXCL9 (but not CXCL1, CXCL5, CXCL8 and IL-6) from human bronchial explants. Roflumilast 80-91 interleukin 6 Homo sapiens 205-209 33354576-0 2020 Tangeretin Inhibition of High-Glucose-Induced IL-1beta, IL-6, TGF-beta1, and VEGF Expression in Human RPE Cells. Glucose 30-37 interleukin 6 Homo sapiens 56-60 33328159-6 2020 The role of HRH4 in high glucose-induced regulation of VEGF, IL-6 and PEDF in ARPE-19 cells and the underlying regulatory mechanism were verified using an RNA interference-mediated knockdown study. Glucose 25-32 interleukin 6 Homo sapiens 61-65 33080187-0 2020 Glutathione S-transferases P1-mediated interleukin-6 in tumor-associated macrophages augments drug-resistance in MCF-7 breast cancer. Glutathione 0-11 interleukin 6 Homo sapiens 39-52 33328159-9 2020 Histamine treatment upregulated VEGF and IL-6 and downregulated PEDF expression in ARPE-19 cells cultivated under hyperglycemic conditions. Histamine 0-9 interleukin 6 Homo sapiens 41-45 33269450-3 2020 Glutoxim in doses of 0.1 and 0.25 mug/ml stimulated production of IL-6 and IL-10 during 24-48 h of culturing, but did not stimulate production of IL-1beta. glutoxim 0-8 interleukin 6 Homo sapiens 66-70 32859615-8 2020 Compared with control, exercise and metformin reduced sTNF-alphaR2: -13.1% (95% CI: -22.9, -1.0) and IL-6: -38.7% (95% CI: -52.3, -18.9); but did not change hs-CRP: -20.5% (95% CI: -44.0, 12.7). Metformin 36-45 interleukin 6 Homo sapiens 101-105 32826430-11 2020 In exploratory analysis, the association of sodium levels and interleukin-6 levels (which has been linked to nonosmotic release of vasopressin) was assessed. Sodium 44-50 interleukin 6 Homo sapiens 62-75 32444919-8 2020 Specifically, IL-6 and IL-23 (M1) were upregulated in SAP compared with AAP and controls (p < 0.05). antiarrhythmic peptide 72-75 interleukin 6 Homo sapiens 14-18 32444919-12 2020 Specifically, IL-6 and IL-23 were augmented SAP over AAP, suggesting a role in the severity of apical lesions. antiarrhythmic peptide 53-56 interleukin 6 Homo sapiens 14-18 32826430-16 2020 Higher interleukin-6 levels correlated with lower sodium levels (p = 0.017). Sodium 50-56 interleukin 6 Homo sapiens 7-20 32895645-10 2020 Clinical responses to anti-IL-6/IL-6-R therapy were accompanied by significant decreases in temperature, oxygen requirement, CRP, IL-6, and IL-10 levels. Oxygen 105-111 interleukin 6 Homo sapiens 27-31 32895645-10 2020 Clinical responses to anti-IL-6/IL-6-R therapy were accompanied by significant decreases in temperature, oxygen requirement, CRP, IL-6, and IL-10 levels. Oxygen 105-111 interleukin 6 Homo sapiens 32-36 32979840-8 2020 Subgroup analysis showed that soy supplementation had a significant impact on decreasing IL-6 and TNF-alpha levels when studies had a long-term intervention (>=12 weeks) and used low dose isoflavone (<100 mg/day). Isoflavones 188-198 interleukin 6 Homo sapiens 89-93 33129099-10 2020 CONCLUSION: Nano-curcumin, as an anti-inflammatory herbal based agent, may be able to modulate the increased rate of inflammatory cytokines especially IL-1beta and IL-6 mRNA expression and cytokine secretion in COVID-19 patients, which may cause an improvement in clinical manifestation and overall recovery. Curcumin 17-25 interleukin 6 Homo sapiens 164-168 32905812-8 2020 In addition, cord BPA concentration was associated with dysregulated TLR stimulated TNF-alpha and IL-6 production, but the correlation was significant only at birth. bisphenol A 18-21 interleukin 6 Homo sapiens 98-102 33045562-5 2020 The results showed that the in vitro treatment of monocytes from preeclamptic women with Sb downregulated the endogenous activation of NF-kappaB and the expression of surface receptors TLR4 and CD64, and reduced the synthesis of the pro-inflammatory cytokines interleukin 1 (IL-1beta), IL-6, IL-8, IL-12p70, IL-23, and tumour necrosis factor alpha (TNF-alpha) compared with cultures not treated with Sb. Silybin 89-91 interleukin 6 Homo sapiens 286-290 32694341-9 2020 A positive correlation was found between BP, enzyme activities and levels of ATP and IL-6. Adenosine Triphosphate 77-80 interleukin 6 Homo sapiens 85-89 33075233-1 2020 Cadmium (Cd) is accumulated in human astrocytes and induces the production of interleukin (IL)-6 and IL-8. Cadmium 0-7 interleukin 6 Homo sapiens 78-96 32694341-11 2020 Positive correlation was found between NTPDase and IL-6 levels (P < 0.05) as well as ATP levels and IL-6 levels. Adenosine Triphosphate 85-88 interleukin 6 Homo sapiens 100-104 33075233-1 2020 Cadmium (Cd) is accumulated in human astrocytes and induces the production of interleukin (IL)-6 and IL-8. Cadmium 9-11 interleukin 6 Homo sapiens 78-96 33038372-5 2020 High glucose-induced NF-kappaB increased the migration and invasion of CCA cells and the expression of downstream NF-kappaB targeted genes associated with aggressiveness, including interleukin-6, a potent triggering signal of the signal transducer and activator of transcription 3 (STAT3) pathway. Glucose 5-12 interleukin 6 Homo sapiens 181-194 32998017-10 2020 SIGNIFICANCE: Paclitaxel could protect against LPS-induced AKI via the regulation of lnc-MALAT1/miR-370-3p/HMGB1 axis and the expression of TNF-alpha, IL-6 and IL-1beta, revealing that paclitaxel might act as a therapy drug in reducing sepsis-associated AKI. Paclitaxel 14-24 interleukin 6 Homo sapiens 151-155 33129041-12 2020 Parental alcohol problems, paternal mental health problems, parental convictions and emotional abuse were associated with lower levels of IL-6. Alcohols 9-16 interleukin 6 Homo sapiens 138-142 33496116-9 2020 The results of molecular docking showed that baicalein,berberine,licochalcone A and 6-gingerol had a high affinity with SRC,STAT3,TNF and IL6. Berberine 55-64 interleukin 6 Homo sapiens 138-141 34056129-11 2020 LDH, IL-1beta, and IL-6 levels were higher in the DHS group compared with the other two groups at 3 months after surgery (P<0.05). dhs 50-53 interleukin 6 Homo sapiens 19-23 32976960-6 2020 RESULTS: Adipose tissue treated with BPA for 24 hours had reduced expression of the proinflammatory genes (IL6, IL1B, TNFA) and adipokines (ADIPOQ, FABP4). bisphenol A 37-40 interleukin 6 Homo sapiens 107-110 33331582-8 2020 Furthermore, the vitamin D deficient (<15 ng/ml) group showed a significantly higher plasma level of IL-6, IL-10, and IL-22 compared to the non-deficient (>=15 ng/ml) group. Vitamin D 17-26 interleukin 6 Homo sapiens 101-105 33252122-7 2020 Proinflammatory cytokine IL-6 also correlated to calcium change in both mild/moderate and severe/critical cases. Calcium 49-56 interleukin 6 Homo sapiens 25-29 33329577-11 2020 However, both PGDHC and Pg-LPS contributed to the senescence of SH-SY5Y cells as indicated by the production of senescence-associated secretory phenotype (SASP) markers, including beta-galactosidase, cathepsin B (CtsB), and pro-inflammatory cytokines TNF-alpha, and IL-6. pgdhc 14-19 interleukin 6 Homo sapiens 266-270 33255269-9 2020 MCP-1 biosynthesis induced by MT-III was dependent on the EP4 receptor, while IL-6 biosynthesis was dependent on EP3 receptor engagement by PGE2. Dinoprostone 140-144 interleukin 6 Homo sapiens 78-82 33228785-9 2020 IL-6 stimulated protein synthesis of Cyr61, which was attenuated by the extracellular signal-related kinase 1/2 (ERK 1/2) inhibitor, PD98059, and knockdown of early growth response 3 (EGR3), but not of JUN. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 133-140 interleukin 6 Homo sapiens 0-4 32882369-8 2020 In the static RHS, the SDS-treated tissues also released significantly high LDH (82 %; p < 0.05) and significantly lower IL-6 release (p < 0.05), corroborating with the other metabolic levels. Sodium Dodecyl Sulfate 23-26 interleukin 6 Homo sapiens 121-125 33198751-9 2020 Dividing patients by treatment received, lower BAL concentrations of IL6 were found in patients treated with steroids as compared to those treated with tocilizumab (p < 0.1) or antivirals (p < 0.05). Steroids 109-117 interleukin 6 Homo sapiens 69-72 33208682-8 2021 IL-6 and lymphopenia remained associated with subsequent PVT development after adjustment for nonselective beta-blockers, spleen size, portosystemic collaterals, oesophageal varices (grade >=2) and ascites, but also with alcohol as the cause for cirrhosis and MELD >=13. Alcohols 221-228 interleukin 6 Homo sapiens 0-4 33191263-2 2020 The aim of the SARICOR study is to demonstrate that early administration of sarilumab (an IL-6 receptor inhibitor) in hospitalised patients with COVID-19, pulmonary infiltrates and a high IL-6 or D-dimer serum level could reduce the progression of ARDS requiring high-flow nasal oxygen or mechanical ventilation (non-invasive or invasive). Oxygen 279-285 interleukin 6 Homo sapiens 90-94 33298879-10 2020 Finally, knockdown of IL-34 in TICs with specific antisense oligonucleotides with: a specific antisesne oligonucleotide decreased IL-6 production and the number of TAMs producing this cytokine. Oligonucleotides 60-76 interleukin 6 Homo sapiens 130-134 33205000-8 2020 When stratifying inpatients in a low- and high oxygen demand group serum iron levels differed significantly between these two groups and showed a high negative correlation with the inflammatory parameters IL-6, procalcitonin, and CRP. Oxygen 47-53 interleukin 6 Homo sapiens 205-209 33205000-8 2020 When stratifying inpatients in a low- and high oxygen demand group serum iron levels differed significantly between these two groups and showed a high negative correlation with the inflammatory parameters IL-6, procalcitonin, and CRP. Iron 73-77 interleukin 6 Homo sapiens 205-209 33227660-5 2020 IL-6 maximal increase correlated with the maximal increase of serum cortisol (rs = 0.48; P = 0.013), salivary cortisol (rs = 0.66; P = 0.012), plasma ACTH (rs = 0.48; P = 0.013) and with the increase in procedure-related symptoms of anxiety and hypoglycemia (rs = 0.57; P = 0.003). Hydrocortisone 68-76 interleukin 6 Homo sapiens 0-4 33227660-5 2020 IL-6 maximal increase correlated with the maximal increase of serum cortisol (rs = 0.48; P = 0.013), salivary cortisol (rs = 0.66; P = 0.012), plasma ACTH (rs = 0.48; P = 0.013) and with the increase in procedure-related symptoms of anxiety and hypoglycemia (rs = 0.57; P = 0.003). Hydrocortisone 110-118 interleukin 6 Homo sapiens 0-4 33177492-5 2020 Additionally, the stromal fibroblasts secrete IL6 as the major cytokine, increases glycolytic flux in the pancreatic tumor cells, and increases lactate efflux in the microenvironment via activation of the STAT signaling pathway. Lactic Acid 144-151 interleukin 6 Homo sapiens 46-49 32786691-6 2020 As a function of IL-6 levels, we identified significant dysregulation in serum levels of various coagulation factors, accompanied by increased levels of antifibrinolytic components, including several serine protease inhibitors (SERPINs). Serine 200-206 interleukin 6 Homo sapiens 17-21 33145838-4 2021 We observed inhibition of IL-6 and CXCL8 secretion from both lung fibroblast models by dexamethasone (maximal inhibition 40 - 90%) and the p38 MAPK inhibitor BIRB (maximal inhibition 30 - 60%), used alone and evidence of increased anti-inflammatory effects when used in combination. Dexamethasone 87-100 interleukin 6 Homo sapiens 26-30 33155879-8 2021 The actions of curcumin are achieved by several mechanisms, such as reducing the expression of interleukin (IL)-1, IL-6, IL-12, and tumor necrosis factor-alpha. Curcumin 15-23 interleukin 6 Homo sapiens 115-119 33145838-4 2021 We observed inhibition of IL-6 and CXCL8 secretion from both lung fibroblast models by dexamethasone (maximal inhibition 40 - 90%) and the p38 MAPK inhibitor BIRB (maximal inhibition 30 - 60%), used alone and evidence of increased anti-inflammatory effects when used in combination. birb 158-162 interleukin 6 Homo sapiens 26-30 33294275-0 2020 MOB1A regulates glucose deprivation-induced autophagy via IL6-STAT3 pathway in gallbladder carcinoma. Glucose 16-23 interleukin 6 Homo sapiens 58-61 33194434-16 2020 GSEA analysis showed that several gene sets associated with tumor development and metastasis, including TGF-beta signaling, PI3K-AKT-mTOR signaling, and IL6-JAK-STAT3 signaling, were significantly enriched in POLR3G high expression phenotype. gsea 0-4 interleukin 6 Homo sapiens 153-156 33146789-10 2021 In addition, using the ROS inhibitor N-acetyl-L-cysteine (NAC), we observed abrogated mRNA expression of several ARPs and production of inflammatory cytokines/chemokines (IL-6, IL-8, MCP-1, and CCL-5) in the CSE-challenged cells suggesting an important role of ROS in regulating CSE-induced autophagy. ros 23-26 interleukin 6 Homo sapiens 171-175 33146789-10 2021 In addition, using the ROS inhibitor N-acetyl-L-cysteine (NAC), we observed abrogated mRNA expression of several ARPs and production of inflammatory cytokines/chemokines (IL-6, IL-8, MCP-1, and CCL-5) in the CSE-challenged cells suggesting an important role of ROS in regulating CSE-induced autophagy. Acetylcysteine 37-56 interleukin 6 Homo sapiens 171-175 33146789-10 2021 In addition, using the ROS inhibitor N-acetyl-L-cysteine (NAC), we observed abrogated mRNA expression of several ARPs and production of inflammatory cytokines/chemokines (IL-6, IL-8, MCP-1, and CCL-5) in the CSE-challenged cells suggesting an important role of ROS in regulating CSE-induced autophagy. Acetylcysteine 58-61 interleukin 6 Homo sapiens 171-175 31736187-8 2020 Dampened IL-1ra and IL-6 in response to stress was observed as a function of alcohol dependence and not moderated by depressive symptoms. Ethanol 77-84 interleukin 6 Homo sapiens 20-24 33144591-12 2020 TMA and cadaverine inhibited LPS-stimulated TNF-alpha and IL-6 secretion by primary human monocytes. Cadaverine 8-18 interleukin 6 Homo sapiens 58-62 32539474-6 2020 After adjusting for demographic and HIV variables, IL-6 and d-dimer remained associated with lack of electricity and having an unprotected water source only in PHIVs (p<0.019). Water 139-144 interleukin 6 Homo sapiens 51-55 32879146-11 2020 Finally, SN significantly inhibited IL-6-induced JAK2 and STAT3 phosphorylation in SW1353 cells. sinomenine 9-11 interleukin 6 Homo sapiens 36-40 33031791-6 2020 Rapamycin inhibits protein synthesis, delays aging, reduces obesity in animal models, and inhibits activities or expression of pro-inflammatory cytokines such as IL-2, IL-6 and, IL-10. Sirolimus 0-9 interleukin 6 Homo sapiens 168-172 33275235-11 2020 Moreover, miR-34a-5p inhibited the proliferation of FLS and inhibited the secretion of TNF-alpha and IL-6 by FLS. mir-34a-5p 10-20 interleukin 6 Homo sapiens 101-105 32730761-14 2020 Multiple linear regression revealed that IL-20, in addition to IL-6, glucose, CRP and D-dimer, was independently associated with the presence of AAD. L-2-Aminoadipic acid 145-148 interleukin 6 Homo sapiens 63-67 32799012-9 2020 Oral supplementation of NAC reduced serum level of C-reactive protein (CRP) [WMD: -0.61 mg/L, 95% CI: -1.18 to -0.03, P = 0.039, I2 = 79.6%], and interleukin-6 (IL-6) [WMD: -0.43 pg/mL, 95% CI: -0.69 to -0.17, P = 0.001, I2 = 89.3%]. Acetylcysteine 24-27 interleukin 6 Homo sapiens 146-159 32799012-9 2020 Oral supplementation of NAC reduced serum level of C-reactive protein (CRP) [WMD: -0.61 mg/L, 95% CI: -1.18 to -0.03, P = 0.039, I2 = 79.6%], and interleukin-6 (IL-6) [WMD: -0.43 pg/mL, 95% CI: -0.69 to -0.17, P = 0.001, I2 = 89.3%]. Acetylcysteine 24-27 interleukin 6 Homo sapiens 161-165 32799012-12 2020 CONCLUSION: Oral NAC supplementation reduced serum level of CRP and IL-6, but did not affect other inflammatory biomarkers. Acetylcysteine 17-20 interleukin 6 Homo sapiens 68-72 32885495-4 2020 Acute exposure of myotubes to IL-6 increased the mitochondrial reactive oxygen species (mtROS) production and oxygen consumption rates (JO2 ) in a manner that was dependent on activation of the JAK/STAT pathway. Reactive Oxygen Species 63-86 interleukin 6 Homo sapiens 30-34 32885495-4 2020 Acute exposure of myotubes to IL-6 increased the mitochondrial reactive oxygen species (mtROS) production and oxygen consumption rates (JO2 ) in a manner that was dependent on activation of the JAK/STAT pathway. Oxygen 72-78 interleukin 6 Homo sapiens 30-34 32946851-8 2020 Besides, patients with higher fasting plasma glucose (FPG) had higher IL-6, IL-8, CRP, and mortality. Glucose 45-52 interleukin 6 Homo sapiens 70-74 32833280-11 2020 Osteocytes secreted exosomes carrying miR-124-3p, Gal-3, and IL-6, which were influenced by high glucose. Glucose 97-104 interleukin 6 Homo sapiens 61-65 33275235-14 2020 CONCLUSIONS: In short, miR-34a-5p can directly inhibit the expression of XBP1, ultimately inhibit the proliferation of FLS, and inhibit the secretion of TNF-alpha and IL-6 by FLS. mir-34a-5p 23-33 interleukin 6 Homo sapiens 167-171 33182059-2 2020 IL-6 is known to be modulated by Vitamin D, and there is preliminary evidence that deficiency of this vitamin is linked to poorer outcomes. Vitamin D 33-42 interleukin 6 Homo sapiens 0-4 32866785-9 2020 The increase in the production of TNF-alpha, IL-6, NO, and PGE2 in IL-1beta-treated HNPCs was abolished by tyrosol treatment. 4-hydroxyphenylethanol 107-114 interleukin 6 Homo sapiens 45-49 33182059-5 2020 To determine whether Vitamin D may be beneficial at lowering IL-6 levels in patients, a limited analysis of trials examining the relationship between these entities published since 2015 was undertaken. Vitamin D 21-30 interleukin 6 Homo sapiens 61-65 33182059-6 2020 Eight out of 11 studies described a significant lowering effect of Vitamin D on IL-6. Vitamin D 67-76 interleukin 6 Homo sapiens 80-84 31983246-6 2020 In vitro studies revealed serum levels of BUN, creatinine, CK and pro-inflammatory cytokines like TNF-alpha, IL-6, and MRP-1 to be elevated in the cisplatin-treated group while reducing glomerular filtration rate. Cisplatin 147-156 interleukin 6 Homo sapiens 109-113 32557888-4 2020 Moreover, in ovo administration of live NDV vaccine plus APS could significantly enhance the serum anti-NDV antibody titres and interferon gamma (IFN-gamma), interleukin (IL)-2, IL-4 and IL-6 concentrations, promote lymphocyte proliferative capability as well as improve the frequencies of CD4+ and CD8+ T cells in peripheral blood. aps 57-60 interleukin 6 Homo sapiens 187-191 32936395-9 2020 SV40-fibroblasts from three healthy controls produced increasing levels of IFN-lambda and IL-6 after 24 h of stimulation with increasing concentrations of poly(I:C), whereas the production of the cytokines was impaired in TLR3 L742F/WT patient SV40-fibroblasts. Poly I 155-161 interleukin 6 Homo sapiens 90-94 32936395-9 2020 SV40-fibroblasts from three healthy controls produced increasing levels of IFN-lambda and IL-6 after 24 h of stimulation with increasing concentrations of poly(I:C), whereas the production of the cytokines was impaired in TLR3 L742F/WT patient SV40-fibroblasts. Carbon 162-164 interleukin 6 Homo sapiens 90-94 32649272-11 2020 Mechanisms include its "calcium-channel blocking" effects that lead to downstream suppression of nuclear factor-Kbeta, interleukin-6, c-reactive protein, and other related endocrine disrupters; its role in regulating renal potassium loss; and its ability to activate and enhance the functionality of vitamin D, among others. Calcium 24-31 interleukin 6 Homo sapiens 119-132 33126443-8 2020 Linalool decreased TLR4, MYD88 and TRIF gene and protein expressions; diminished related inflammatory mediators such as TNF-alpha, IL-1beta, IL-6, and NF-kappaB; and down-regulated HMBG1. linalool 0-8 interleukin 6 Homo sapiens 141-145 32536325-0 2020 Abstinent patients with alcohol use disorders show an altered plasma cytokine profile: Identification of both interleukin 6 and interleukin 17A as potential biomarkers of consumption and comorbid liver and pancreatic diseases. Alcohols 24-31 interleukin 6 Homo sapiens 110-123 32862739-8 2020 In vitro, blockading HDAC6 with a selective inhibitor tubastatin A (TA) or silencing HDAC6 with a small interfering RNA (siRNA) prominently decreased IL-6-stimulated VEGF expression in cultured human peritoneal mesothelial cells (HPMCs), and inhibited proliferation and vasoformation of human umbilical vein endothelial cells (HUVECs). tubastatin A 54-66 interleukin 6 Homo sapiens 150-154 32862739-8 2020 In vitro, blockading HDAC6 with a selective inhibitor tubastatin A (TA) or silencing HDAC6 with a small interfering RNA (siRNA) prominently decreased IL-6-stimulated VEGF expression in cultured human peritoneal mesothelial cells (HPMCs), and inhibited proliferation and vasoformation of human umbilical vein endothelial cells (HUVECs). tubastatin A 68-70 interleukin 6 Homo sapiens 150-154 33080435-5 2020 Impaired spermatogenesis via COVID-19 decreases the level of testosterone by disturbing cytokines such as TNF-alpha, IL-4, IL-6, and IL-12 and further, attenuates the sperm count. Testosterone 61-73 interleukin 6 Homo sapiens 123-127 33130987-9 2020 Autocrine GH-mediated IL-6, IL-8, IL-10 expressions were downregulated by curcumin treatment. Curcumin 74-82 interleukin 6 Homo sapiens 22-26 32542535-6 2020 Exposure to 50 muM TBHP increased caspase 3/7 activity, an indicator of apoptosis, after 8 and 24 h. Antioxidant treatment markedly reduced TBHP-stimulated caspase 3/7 activity, PGE2 release, and IL-6 release. tert-Butylhydroperoxide 19-23 interleukin 6 Homo sapiens 196-200 32542535-6 2020 Exposure to 50 muM TBHP increased caspase 3/7 activity, an indicator of apoptosis, after 8 and 24 h. Antioxidant treatment markedly reduced TBHP-stimulated caspase 3/7 activity, PGE2 release, and IL-6 release. tert-Butylhydroperoxide 140-144 interleukin 6 Homo sapiens 196-200 32542535-7 2020 TBHP-stimulated IL-6 release was blocked by PD169316 but unaltered by indomethacin. tert-Butylhydroperoxide 0-4 interleukin 6 Homo sapiens 16-20 32542535-8 2020 These data suggest that TBHP-stimulated IL-6 release and caspase 3/7 activation were independent of PGE2 yet were interrupted by treatments with known antioxidant properties, providing new insight into relationships between PGE2, IL-6, and apoptosis under conditions of chemically induced cellular oxidation. tert-Butylhydroperoxide 24-28 interleukin 6 Homo sapiens 40-44 32542535-8 2020 These data suggest that TBHP-stimulated IL-6 release and caspase 3/7 activation were independent of PGE2 yet were interrupted by treatments with known antioxidant properties, providing new insight into relationships between PGE2, IL-6, and apoptosis under conditions of chemically induced cellular oxidation. tert-Butylhydroperoxide 24-28 interleukin 6 Homo sapiens 230-234 32542535-8 2020 These data suggest that TBHP-stimulated IL-6 release and caspase 3/7 activation were independent of PGE2 yet were interrupted by treatments with known antioxidant properties, providing new insight into relationships between PGE2, IL-6, and apoptosis under conditions of chemically induced cellular oxidation. Dinoprostone 224-228 interleukin 6 Homo sapiens 40-44 33116117-10 2020 Furthermore, results showed that the stemness inhibition by metformin was associated with blockade of the IL6-stat3 axis. Metformin 60-69 interleukin 6 Homo sapiens 106-109 33083921-9 2021 CONCLUSIONS: Our data suggest that in premenopausal women with anovulation, a proinflammatory condition mediated by IL-6 is associated with lower oxygen levels during sleep. Oxygen 146-152 interleukin 6 Homo sapiens 116-120 33116117-11 2020 Survival analysis demonstrated that overexpression of IL6 and stemness markers was associated with poor survival in HNSCC patients, indicating that including metformin to target these proteins might improve patient prognosis. Metformin 158-167 interleukin 6 Homo sapiens 54-57 33312105-0 2020 Interleukin-6 is associated with tryptophan metabolism and signs of depression in individuals with carbohydrate malabsorption. Tryptophan 33-43 interleukin 6 Homo sapiens 0-13 33312105-4 2020 Serum IL-6 levels were positively correlated with the BDI score (p = 0.001, rho = 0.205) and indicators of TRP metabolism (KYN/TRP ratio, KYN) (P-values < 0.05, rho = 0.176 and 0.136). Tryptophan 107-110 interleukin 6 Homo sapiens 6-10 33312105-4 2020 Serum IL-6 levels were positively correlated with the BDI score (p = 0.001, rho = 0.205) and indicators of TRP metabolism (KYN/TRP ratio, KYN) (P-values < 0.05, rho = 0.176 and 0.136). Tryptophan 127-130 interleukin 6 Homo sapiens 6-10 33312105-7 2020 IL-6 and LBP were associated with indicators of TRP metabolism. Tryptophan 48-51 interleukin 6 Homo sapiens 0-4 33195318-4 2020 Inhibiting CRS by agents suppressing IL-6 may relieve symptoms, shorten the hospital stay and reduce the need for oxygen therapy. Oxygen 114-120 interleukin 6 Homo sapiens 37-41 33144846-7 2020 Both BH and PH groups were consistent in presenting a positive correlation between concentrations of IL-6 and IL-1beta. Bh 5-7 interleukin 6 Homo sapiens 101-105 33144846-8 2020 A fundamental difference in IL-10 responsiveness between the two groups was noted; specifically, levels of IL-10 were positively correlated with IL-6 in the BH group, whereas in the PH group, levels of IL-10 were positively correlated with IL-1beta. Bh 157-159 interleukin 6 Homo sapiens 145-149 32526304-6 2020 Additionally, HSP-W significantly induced NO and ROS production as well as the release of IL-1beta, IFN-gamma, TNF-alpha, and IL-6, and upregulated pinocytic and phagocytic capacities of THP-1 cells. hsp-w 14-19 interleukin 6 Homo sapiens 126-130 32868342-8 2020 In addition, compared to SS2-infected STEC, PCV2/SS2 coinfection and pretreatment of STEC with NAC prior to SS2 infection both down-regulated the expression of inflammatory cytokines IL-6, TNF-alpha and IL-1beta. Acetylcysteine 95-98 interleukin 6 Homo sapiens 183-187 32791151-10 2020 Hyperbaric oxygen promoted the proliferation, migration and ROS production, as well as the expression of SDF-1 and VEGFA in HSF. Oxygen 11-17 interleukin 6 Homo sapiens 124-127 33178716-9 2020 Increased levels of interleukin-6, blood urea nitrogen, and creatine kinase were associated with the development of SARS-CoV-2-induced sepsis, and an elevated production of interleukin-6 was found to be an independent risk factor for the progression to critical illness among septic COVID-19 patients. Urea 41-45 interleukin 6 Homo sapiens 173-186 32791151-12 2020 CONCLUSION: Hyperbaric oxygen potentiates angiogenesis and diabetic wound healing by activating HIF-1alpha signaling, so as to promote the expression of VEGF/SDF-1 in HSF and the expression of VEGFR/CXCR4 in HUVECS, ultimately to promote the proliferation of HSF and the angiogenesis of HUVECS. Oxygen 23-29 interleukin 6 Homo sapiens 167-170 32791151-12 2020 CONCLUSION: Hyperbaric oxygen potentiates angiogenesis and diabetic wound healing by activating HIF-1alpha signaling, so as to promote the expression of VEGF/SDF-1 in HSF and the expression of VEGFR/CXCR4 in HUVECS, ultimately to promote the proliferation of HSF and the angiogenesis of HUVECS. Oxygen 23-29 interleukin 6 Homo sapiens 259-262 33057107-5 2020 MDP water extract significantly inhibited the activation of NF-kappaB and IRF reporters, downstream signaling pathways and the production of IL-6 and TNF-alpha, in a dose-dependent manner. Water 4-9 interleukin 6 Homo sapiens 141-145 33066024-12 2020 Quininib significantly downregulated IL-2 and IL-6 in Mel285 cells (p < 0.05) but significantly upregulated IL-10, IL-1beta, IL-2 (p < 0.0001), IL-13, IL-8 (p < 0.001), IL-12p70 and IL-6 (p < 0.05) in OMM2.5 cells. quininib 0-8 interleukin 6 Homo sapiens 46-50 33066024-12 2020 Quininib significantly downregulated IL-2 and IL-6 in Mel285 cells (p < 0.05) but significantly upregulated IL-10, IL-1beta, IL-2 (p < 0.0001), IL-13, IL-8 (p < 0.001), IL-12p70 and IL-6 (p < 0.05) in OMM2.5 cells. quininib 0-8 interleukin 6 Homo sapiens 182-186 33066025-10 2020 In this milieu, we demonstrated that (-)-catechin decreased the expression and secretion of proinflammatory cytokines, including interleukin (IL)-1beta and IL-6. Catechin 41-49 interleukin 6 Homo sapiens 156-160 33046027-10 2020 The GSEA results provided further functional annotations, including complement system, IL6/JAK/STAT3 signalling pathway and inflammatory response pathways. gsea 4-8 interleukin 6 Homo sapiens 87-90 33023630-9 2020 As previously reported, DEX or IgG alone significantly suppressed TNF-alpha-induced production of IL-6 and G-CSF and mRNA expression, but induction of those cytokines by IL-1 s (IL-1alpha and IL-1beta) was resistant to high-dose IgG. Dexamethasone 24-27 interleukin 6 Homo sapiens 98-102 33123172-5 2020 Our results show that lactate significantly attenuates LPS stimulated macrophage TNF-alpha and IL-6 production. Lactic Acid 22-29 interleukin 6 Homo sapiens 95-99 32726657-13 2020 However, NAC effects were significant in ameliorating TNF-alpha and IL-6 using sensitivity analysis. Acetylcysteine 9-12 interleukin 6 Homo sapiens 68-72 32726657-15 2020 The effects of NAC on amending TNF-alpha and IL-6 levels were significant after sensitivity analysis. Acetylcysteine 15-18 interleukin 6 Homo sapiens 45-49 33082817-0 2020 Feng-Liao-Chang-Wei-Kang Combined with 5-Fluorouracil Synergistically Suppresses Colitis-Associated Colorectal Cancer via the IL-6/STAT3 Signalling Pathway. Fluorouracil 39-53 interleukin 6 Homo sapiens 126-130 33082817-11 2020 Results: FLCWK enhanced the ability of 5-FU to promote apoptosis by inhibiting the proliferation of HCT116 cells and blocking the IL-6/STAT3 pathway. Fluorouracil 39-43 interleukin 6 Homo sapiens 130-134 32847938-0 2020 An IL6-Adenosine Positive Feedback Loop between CD73+ gammadeltaTregs and CAFs Promotes Tumor Progression in Human Breast Cancer. Adenosine 7-16 interleukin 6 Homo sapiens 3-6 31965901-8 2020 These results revealed the essential role of autophagy in endothelial cell integrity and revealed that the disruption of endothelial autophagy could lead to significant pathological IL6-dependent EndMT and organ fibrosis.Abbreviations: 3-MA: 3-methyladenine; ATG5: autophagy related 5; EndMT: endothelial-to-mesenchymal transition; HES: hematoxylin and eosin stain; HFD: high-fat diet; HMVECs: human microvascular endothelial cells; IFNG: interferon gamma; IL6: interleukin 6; MTS: Masson"s trichrome staining; NFD: normal-fat diet; siRNA: small interfering RNA; SMAD3: SMAD family member 3; TGFB: transforming growth factor beta; TNF: tumor necrosis factor; VEGFA: vascular endothelial growth factor A. 3-methyladenine 242-257 interleukin 6 Homo sapiens 182-185 32531426-8 2020 Furthermore, prenatal Trp levels and the Kyn/Trp ratio moderate the association between IL-6 levels and depressive symptoms during the perinatal and the post-partum period. Tryptophan 22-25 interleukin 6 Homo sapiens 88-92 32531426-8 2020 Furthermore, prenatal Trp levels and the Kyn/Trp ratio moderate the association between IL-6 levels and depressive symptoms during the perinatal and the post-partum period. Tryptophan 45-48 interleukin 6 Homo sapiens 88-92 32580099-4 2020 The sustained release of the copper ions from Cu-EGCG was demonstrated in vitro, and biocompatible Cu-EGCG can scavenge intracellular ROS, reduce cell death in the presence of cytotoxic levels of ROS, and decrease the expression of pro-inflammatory cytokines (TNF-alpha, IL-6). Copper 29-35 interleukin 6 Homo sapiens 271-275 32847938-0 2020 An IL6-Adenosine Positive Feedback Loop between CD73+ gammadeltaTregs and CAFs Promotes Tumor Progression in Human Breast Cancer. gammadeltatregs 54-69 interleukin 6 Homo sapiens 3-6 32847938-3 2020 We further demonstrated that cancer-associated fibroblast (CAF)-derived IL6, rather than TGFbeta1, induced CD73+ gammadeltaTreg differentiation from paired normal breast tissues via the IL6/STAT3 pathway to produce more adenosine and become potent immunosuppressive T cells. Adenosine 220-229 interleukin 6 Homo sapiens 72-75 32847938-4 2020 CD73+ gammadeltaTregs could in turn promote IL6 secretion by CAFs through adenosine/A2BR/p38MAPK signaling, thereby forming an IL6-adenosine positive feedback loop. gammadeltatregs 6-21 interleukin 6 Homo sapiens 44-47 32847938-4 2020 CD73+ gammadeltaTregs could in turn promote IL6 secretion by CAFs through adenosine/A2BR/p38MAPK signaling, thereby forming an IL6-adenosine positive feedback loop. gammadeltatregs 6-21 interleukin 6 Homo sapiens 127-130 32847938-4 2020 CD73+ gammadeltaTregs could in turn promote IL6 secretion by CAFs through adenosine/A2BR/p38MAPK signaling, thereby forming an IL6-adenosine positive feedback loop. Adenosine 74-83 interleukin 6 Homo sapiens 44-47 32847938-4 2020 CD73+ gammadeltaTregs could in turn promote IL6 secretion by CAFs through adenosine/A2BR/p38MAPK signaling, thereby forming an IL6-adenosine positive feedback loop. Adenosine 74-83 interleukin 6 Homo sapiens 127-130 32847938-4 2020 CD73+ gammadeltaTregs could in turn promote IL6 secretion by CAFs through adenosine/A2BR/p38MAPK signaling, thereby forming an IL6-adenosine positive feedback loop. Adenosine 131-140 interleukin 6 Homo sapiens 44-47 32847938-4 2020 CD73+ gammadeltaTregs could in turn promote IL6 secretion by CAFs through adenosine/A2BR/p38MAPK signaling, thereby forming an IL6-adenosine positive feedback loop. Adenosine 131-140 interleukin 6 Homo sapiens 127-130 32847938-6 2020 The data indicate that the IL6-adenosine loop between CD73+ gammadeltaTregs and CAFs is important to promote immunosuppression and tumor progression in human breast cancer, which may be critical for tumor immunotherapy. Adenosine 31-40 interleukin 6 Homo sapiens 27-30 32755466-10 2020 IL-1beta or IL-6 in the absence of hMSCs prolonged action potential duration but only IL-6 increased Ca2+ alternans and promoted spontaneous calcium release activity in human cardiac myocytes derived from induced pluripotent stem cells, replicating the effects of failing hMSCs. Calcium 141-148 interleukin 6 Homo sapiens 86-90 32702508-6 2020 We show that mother"s exposure to BPA increases proliferation of the spleen T helper 17 (Th17) cells and serum protein level of IL-17 in the offspring; however, VitD3 supplementation in mothers dose-dependently ameliorated these BPA-induced side effects on the immune system in the offspring as evidenced by attenuated upregulation of Th17 proliferation, and RORgammat, IL-17, IL-6, and IL-23 expressions in the offspring. bisphenol A 34-37 interleukin 6 Homo sapiens 377-381 32648790-3 2020 AIMS: We are evaluating the blood inflammatory biomarkers: C-reactive protein and interleukin 6, as a potential consequence of ayahuasca intake and their correlation with serum cortisol and brain-derived neurotrophic factor levels. Hydrocortisone 177-185 interleukin 6 Homo sapiens 82-95 32458347-4 2020 Apigenin also ameliorated inflammation by downregulating tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and upregulating IL-10. Apigenin 0-8 interleukin 6 Homo sapiens 98-111 32458347-4 2020 Apigenin also ameliorated inflammation by downregulating tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and upregulating IL-10. Apigenin 0-8 interleukin 6 Homo sapiens 113-117 32458347-5 2020 Consistently, the elevated ALT and AST level; the impaired balance between SOD, GSH activity, and excessive ROS; and the increased gene expression of TNF-alpha and IL-6 resulting from H2O2-induced oxidative stress were restored by apigenin. Hydrogen Peroxide 184-188 interleukin 6 Homo sapiens 164-168 32458347-5 2020 Consistently, the elevated ALT and AST level; the impaired balance between SOD, GSH activity, and excessive ROS; and the increased gene expression of TNF-alpha and IL-6 resulting from H2O2-induced oxidative stress were restored by apigenin. Apigenin 231-239 interleukin 6 Homo sapiens 164-168 32720970-0 2020 Association between interleukin-6 gene polymorphism and iron regulation in hemodialysis patients infected with HCV. Iron 56-60 interleukin 6 Homo sapiens 20-33 32720970-2 2020 IL-6 stimulates the release of hepcidin from the liver, suppresses intestinal iron uptake, and releases iron from internal stores. Iron 78-82 interleukin 6 Homo sapiens 0-4 32720970-2 2020 IL-6 stimulates the release of hepcidin from the liver, suppresses intestinal iron uptake, and releases iron from internal stores. Iron 104-108 interleukin 6 Homo sapiens 0-4 32636028-0 2020 Corrigendum to "Macrophages induce EMT to promote invasion of lung cancer cells through the IL-6-mediated COX-2/PGE2/beta-catenin signalling pathway" [Mol. Dinoprostone 112-116 interleukin 6 Homo sapiens 92-96 32447047-9 2020 Concomitantly, hyperoside also attenuated paclitaxel-mediated anti-apoptotic Bcl-2 expression, but enhanced the effects of paclitaxel on pro-apoptotic Bax expression, and pro-inflammatory cytokine IL-6 and IL-6 levels in MDA-MB-231 cells. hyperoside 15-25 interleukin 6 Homo sapiens 197-201 32447047-9 2020 Concomitantly, hyperoside also attenuated paclitaxel-mediated anti-apoptotic Bcl-2 expression, but enhanced the effects of paclitaxel on pro-apoptotic Bax expression, and pro-inflammatory cytokine IL-6 and IL-6 levels in MDA-MB-231 cells. hyperoside 15-25 interleukin 6 Homo sapiens 206-210 32945430-11 2020 In addition, HG activated inflammatory factors, such as TNF-alpha, IL-1beta and IL-6; however, their levels were suppressed when cells were treated with FPS-ZM1 or the TXNIP/NLRP3 pathway inhibitor, resveratrol (Res). Resveratrol 199-210 interleukin 6 Homo sapiens 80-84 32472655-7 2020 Parthenolide is the principal sesquiterpene lactones and the main biologically active constituent Tanacetum parthenium (commonly known as feverfew) which has could significantly reduce IL-1, IL-2, IL-6, IL-8, and TNF-alpha production pathways established in several human cell line models in vitro and in vivo studies. parthenolide 0-12 interleukin 6 Homo sapiens 197-201 32814232-8 2020 RESULTS: We found that punicalagin and curcumin significantly supressed TNF-induced pro-inflammatory cytokine (IL1A, IL1B, and IL6) and chemokine (CCL2-4, CXCL1, CXCL5 and CXCL8) expression in human placenta, VAT and SAT. Curcumin 39-47 interleukin 6 Homo sapiens 127-130 32863319-0 2020 Glucose transporter 4 mediates LPS-induced IL-6 production in osteoblasts under high glucose conditions. Glucose 0-7 interleukin 6 Homo sapiens 43-47 32840447-12 2020 A limited amount of IL-6 and IL-8 was released by ionomycin-exposed HMC-1 cells. Ionomycin 50-59 interleukin 6 Homo sapiens 20-24 33289658-9 2020 In post-hoc analyses, associations between baseline IL-6 levels and symptom reduction were strongest in patients treated with either ziprasidone or quetiapine. ziprasidone 133-144 interleukin 6 Homo sapiens 52-56 32942936-8 2020 Furthermore, downregulation of ROCK2 attenuated alcohol-induced inflammation by reducing the levels of pro-inflammatory cytokines (tumor necrosis factor (TNF)-alpha and interleukin (IL)-6) and enhanced the level of anti-inflammatory IL-10. Alcohols 48-55 interleukin 6 Homo sapiens 169-187 32863319-0 2020 Glucose transporter 4 mediates LPS-induced IL-6 production in osteoblasts under high glucose conditions. Glucose 85-92 interleukin 6 Homo sapiens 43-47 32992775-3 2020 Based on the evidence attesting to the ability of glutathione (GSH) to inhibit viral replication and decrease levels of IL-6 in human immunodeficiency virus (HIV) and tuberculosis (TB) patients, as well as beneficial effects of GSH on other pulmonary diseases processes, we believe the use of liposomal GSH could be beneficial in COVID-19 patients. Glutathione 50-61 interleukin 6 Homo sapiens 120-124 32992775-3 2020 Based on the evidence attesting to the ability of glutathione (GSH) to inhibit viral replication and decrease levels of IL-6 in human immunodeficiency virus (HIV) and tuberculosis (TB) patients, as well as beneficial effects of GSH on other pulmonary diseases processes, we believe the use of liposomal GSH could be beneficial in COVID-19 patients. Glutathione 63-66 interleukin 6 Homo sapiens 120-124 32863319-8 2020 RESULTS: LPS and glucose increased the mRNA expression of IL-6, coupled with a decrease in the mRNA expression of OCN, which is associated with IL-6 and glucose. Glucose 17-24 interleukin 6 Homo sapiens 58-62 32863319-8 2020 RESULTS: LPS and glucose increased the mRNA expression of IL-6, coupled with a decrease in the mRNA expression of OCN, which is associated with IL-6 and glucose. Glucose 17-24 interleukin 6 Homo sapiens 144-148 32863319-11 2020 Furthermore, GLUT4 inhibitor, WZB117, blocked the stimulatory effect of glucose on LPS-induced IL-6 mRNA expression. Glucose 72-79 interleukin 6 Homo sapiens 95-99 32863319-13 2020 CONCLUSION: These results suggest that high glucose levels increase LPS-induced IL-6 expression mediated by GLUT4. Glucose 44-51 interleukin 6 Homo sapiens 80-84 32924825-8 2022 Dex showed stronger affinity to its theoretical (glucocorticoid) receptor with a superior docking score of -14.7 and a good binding energy value of -147.48 kcal/mol; while short hydrogen bond distances were observed in both Mpro and IL-6 when compared to glucocorticoid receptor. Dexamethasone 0-3 interleukin 6 Homo sapiens 233-237 33101052-0 2020 Ouabain Suppresses IL-6/STAT3 Signaling and Promotes Cytokine Secretion in Cultured Skeletal Muscle Cells. Ouabain 0-7 interleukin 6 Homo sapiens 19-23 33101052-4 2020 Here, we determined whether ouabain, a prototypical CTS, modulates IL-6 signaling and secretion in the cultured human skeletal muscle cells. Ouabain 28-35 interleukin 6 Homo sapiens 67-71 33101052-5 2020 Ouabain (2.5-50 nM) suppressed the abundance of STAT3, a key transcription factor downstream of the IL-6 receptor, as well as its basal and IL-6-stimulated phosphorylation. Ouabain 0-7 interleukin 6 Homo sapiens 100-104 32967723-10 2020 We also found that peptides 7118TGAKIKLVGT7127 derived from MUC19 and 508AAAAGPANVH517 derived from SIX5 reduced the expression levels of TNF-alpha, IL-1beta, and IL-6 in H2O2-treated human lung epithelial cells. Hydrogen Peroxide 171-175 interleukin 6 Homo sapiens 163-167 32967076-5 2020 Patients treated with metformin showed decreased levels of all analyzed serum pro-inflammatory markers (TNFalpha, IL6, IL1beta and MCP1) and a downwards trend in IL18 levels associated with a lower production of oxidative stress markers in leukocytes (mitochondrial ROS and myeloperoxidase (MPO)). Metformin 22-31 interleukin 6 Homo sapiens 114-117 32927792-7 2020 Both formulations, however, delivered sufficient amounts of DXM to effectively suppress the production of interleukin-6 (IL-6), interleukin-8 (IL-8) and Thymic Stromal Lymphopoietin (TSLP). Dexamethasone 60-63 interleukin 6 Homo sapiens 106-119 32927704-8 2020 The altered fatty acid profile was associated with an increased synthesis of the pro-inflammatory prostaglandin PGE2, which correlated with the upregulation of numerous NFkB-dependent pro-inflammatory mediators, including interleukin-1 (IL-1), interleukin-6 (IL-6), C-C motif chemokine ligand 2 (CCL2), and tumor necrosis factor-alpha (TNFalpha). Fatty Acids 12-22 interleukin 6 Homo sapiens 244-257 32927704-8 2020 The altered fatty acid profile was associated with an increased synthesis of the pro-inflammatory prostaglandin PGE2, which correlated with the upregulation of numerous NFkB-dependent pro-inflammatory mediators, including interleukin-1 (IL-1), interleukin-6 (IL-6), C-C motif chemokine ligand 2 (CCL2), and tumor necrosis factor-alpha (TNFalpha). Fatty Acids 12-22 interleukin 6 Homo sapiens 259-263 32927704-8 2020 The altered fatty acid profile was associated with an increased synthesis of the pro-inflammatory prostaglandin PGE2, which correlated with the upregulation of numerous NFkB-dependent pro-inflammatory mediators, including interleukin-1 (IL-1), interleukin-6 (IL-6), C-C motif chemokine ligand 2 (CCL2), and tumor necrosis factor-alpha (TNFalpha). Prostaglandins 98-111 interleukin 6 Homo sapiens 244-257 32927704-8 2020 The altered fatty acid profile was associated with an increased synthesis of the pro-inflammatory prostaglandin PGE2, which correlated with the upregulation of numerous NFkB-dependent pro-inflammatory mediators, including interleukin-1 (IL-1), interleukin-6 (IL-6), C-C motif chemokine ligand 2 (CCL2), and tumor necrosis factor-alpha (TNFalpha). Prostaglandins 98-111 interleukin 6 Homo sapiens 259-263 32927704-8 2020 The altered fatty acid profile was associated with an increased synthesis of the pro-inflammatory prostaglandin PGE2, which correlated with the upregulation of numerous NFkB-dependent pro-inflammatory mediators, including interleukin-1 (IL-1), interleukin-6 (IL-6), C-C motif chemokine ligand 2 (CCL2), and tumor necrosis factor-alpha (TNFalpha). Dinoprostone 112-116 interleukin 6 Homo sapiens 244-257 32927704-8 2020 The altered fatty acid profile was associated with an increased synthesis of the pro-inflammatory prostaglandin PGE2, which correlated with the upregulation of numerous NFkB-dependent pro-inflammatory mediators, including interleukin-1 (IL-1), interleukin-6 (IL-6), C-C motif chemokine ligand 2 (CCL2), and tumor necrosis factor-alpha (TNFalpha). Dinoprostone 112-116 interleukin 6 Homo sapiens 259-263 32927792-7 2020 Both formulations, however, delivered sufficient amounts of DXM to effectively suppress the production of interleukin-6 (IL-6), interleukin-8 (IL-8) and Thymic Stromal Lymphopoietin (TSLP). Dexamethasone 60-63 interleukin 6 Homo sapiens 121-125 33013867-7 2020 The findings of this study verified that rMgPa could induce the secretion of eCypA in SV-HUC-1 cells and thus promote the protein and mRNA expression of IL-1beta, IL-6, TNF-alpha and MMP-9 via CypA-CD147 interaction and thus activating ERK-NF-kappaB pathway, which is beneficial to elucidate the pathogenesis and possible pathogenic mechanism of M. genitalium to host cells. rmgpa 41-46 interleukin 6 Homo sapiens 163-167 32907617-2 2020 Interleukin (IL)-6 is implicated in both the pathogenesis of RA and in glucose homeostasis; this post hoc analysis investigated the effects of IL-6 receptor vs. tumour necrosis factor inhibition on glycosylated haemoglobin (HbA1c) in patients with RA with or without diabetes. Glucose 71-78 interleukin 6 Homo sapiens 0-18 32782515-1 2020 Efficacy of sodium valproate combined with levetiracetam (LEV) in pediatric epilepsy and its influence on neuron-specific enolase (NSE), interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) as well as electroencephalogram (EEG) improvement were studied. Levetiracetam 58-61 interleukin 6 Homo sapiens 137-150 33131385-0 2020 Reactive Oxygen Species Secreted by Leukocytes in Semen Induce Self-Expression of Interleukin-6 and Affect Sperm Quality. Reactive Oxygen Species 0-23 interleukin 6 Homo sapiens 82-95 33131385-9 2020 A considerable amount of ROS can upregulate the expression of IL-6 in leukocytes via the nuclear factor kappa-B (NF-kB) pathway. Reactive Oxygen Species 25-28 interleukin 6 Homo sapiens 62-66 32768938-0 2020 Yidu-toxicity blocking lung decoction ameliorates inflammation in severe pneumonia of SARS-COV-2 patients with Yidu-toxicity blocking lung syndrome by eliminating IL-6 and TNF-a. yidu 0-4 interleukin 6 Homo sapiens 163-167 32768938-0 2020 Yidu-toxicity blocking lung decoction ameliorates inflammation in severe pneumonia of SARS-COV-2 patients with Yidu-toxicity blocking lung syndrome by eliminating IL-6 and TNF-a. yidu 111-115 interleukin 6 Homo sapiens 163-167 32441799-9 2020 In addition, silencing the expression of CYLD resulted in increase of the expression level of IL-6, TGF-beta and TNF-alpha, which may contribute to acquired resistance of PC-9 cells to gefitinib. Gefitinib 185-194 interleukin 6 Homo sapiens 94-98 32782494-0 2020 Curcumin affects ox-LDL-induced IL-6, TNF-alpha, MCP-1 secretion and cholesterol efflux in THP-1 cells by suppressing the TLR4/NF-kappaB/miR33a signaling pathway. Curcumin 0-8 interleukin 6 Homo sapiens 32-36 32899726-9 2020 Curcumin and CGA together reduced the mRNA expression of pro-inflammatory cytokines [TNF-alpha (~88%) and IL-6 (~99%)], and COX-2 (~92%), possibly by suppression of NF-kappaB (~78%), IkappaB-beta-kinase (~60%) and TLR-4 receptor (~72%) at the mRNA level. Curcumin 0-8 interleukin 6 Homo sapiens 106-110 32768946-4 2020 Inflammatory mediators, such as interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) are highly upregulated in OA joints and induce ROS production and expression of matrix degrading proteases leading to cartilage extracellular matrix degradation and joint dysfunction. Reactive Oxygen Species 174-177 interleukin 6 Homo sapiens 106-119 32768946-4 2020 Inflammatory mediators, such as interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) are highly upregulated in OA joints and induce ROS production and expression of matrix degrading proteases leading to cartilage extracellular matrix degradation and joint dysfunction. Reactive Oxygen Species 174-177 interleukin 6 Homo sapiens 121-125 32782494-9 2020 However, pretreatment with curcumin increased the expression of ABCA1 and cholesterol efflux and suppressed secretion of TNF-alpha, MCP-1 and Il-6. Curcumin 27-35 interleukin 6 Homo sapiens 142-146 32782515-8 2020 In the treatment of pediatric epilepsy, sodium valproate combined with LEV produces better efficacy, fewer adverse reactions, significantly improves patients" QOL and notably lowers the content of NSE, IL-6 and hs-CRP with notable EEG improvement, so it is a safe and reliable treatment that is worth popularization. Levetiracetam 71-74 interleukin 6 Homo sapiens 202-206 32962815-0 2020 Estrogen signaling differentially alters iron metabolism in monocytes in an Interleukin 6-dependent manner. Iron 41-45 interleukin 6 Homo sapiens 76-89 32962815-8 2020 While treatment of U937 cells with interleukin 6 (IL-6) resulted in increased expression of hepcidin, dexamethasone treatment resulted in reduced hepcidin synthesis relative to E2- or dexamethasone + E2-treated cells; IL-6 silencing also resulted in reduced hepcidin synthesis in U937 cells. Dexamethasone 102-115 interleukin 6 Homo sapiens 218-222 32962815-2 2020 Previous work has shown that while IL-6 upregulates hepcidin synthesis and enhances iron sequestration, E2 reduces hepcidin synthesis and increases iron release. Iron 84-88 interleukin 6 Homo sapiens 35-39 32962815-10 2020 These findings suggest that E2 differentially alters iron metabolism in monocytes in an IL-6 dependent manner. Estradiol 28-30 interleukin 6 Homo sapiens 88-92 32962815-10 2020 These findings suggest that E2 differentially alters iron metabolism in monocytes in an IL-6 dependent manner. Iron 53-57 interleukin 6 Homo sapiens 88-92 32962815-3 2020 Given that E2 upregulates IL-6 production in monocytes, it is likely that the exact effect of E2 on iron metabolism in monocytes is shaped by its effect on IL-6 expression. Estradiol 11-13 interleukin 6 Homo sapiens 26-30 32962815-3 2020 Given that E2 upregulates IL-6 production in monocytes, it is likely that the exact effect of E2 on iron metabolism in monocytes is shaped by its effect on IL-6 expression. Estradiol 11-13 interleukin 6 Homo sapiens 156-160 32962815-3 2020 Given that E2 upregulates IL-6 production in monocytes, it is likely that the exact effect of E2 on iron metabolism in monocytes is shaped by its effect on IL-6 expression. Estradiol 94-96 interleukin 6 Homo sapiens 26-30 32962815-3 2020 Given that E2 upregulates IL-6 production in monocytes, it is likely that the exact effect of E2 on iron metabolism in monocytes is shaped by its effect on IL-6 expression. Estradiol 94-96 interleukin 6 Homo sapiens 156-160 32962815-3 2020 Given that E2 upregulates IL-6 production in monocytes, it is likely that the exact effect of E2 on iron metabolism in monocytes is shaped by its effect on IL-6 expression. Iron 100-104 interleukin 6 Homo sapiens 156-160 32815446-10 2020 Impaired endothelial function with above-normal BP is mediated by excessive reactive oxygen species signaling associated with increased endothelial expression of nicotinamide adenine dinucleotide phosphate oxidase and circulating interleukin-6. Oxygen 85-91 interleukin 6 Homo sapiens 230-243 32729244-3 2020 In this randomized, placebo-controlled trial, we aimed to evaluate the potential reflection of short-term xylitol consumption on pro-inflammatory cytokines (TNF-alpha, IL-6 and IL-8) and S. mutans counts by ELISA and qPCR (Quantitative real-time PCR), respectively. Xylitol 106-113 interleukin 6 Homo sapiens 168-172 32652260-0 2020 Iron promotes breast cancer cell migration via IL-6/JAK2/STAT3 signaling pathways in a paracrine or autocrine IL-6-rich inflammatory environment. Iron 0-4 interleukin 6 Homo sapiens 47-51 32945158-9 2020 Histamine is involved in the expression of chemokine IL-8 and cytokine IL-6, an effect that can be inhibited by histamine receptor antagonists. Histamine 0-9 interleukin 6 Homo sapiens 71-75 32945158-9 2020 Histamine is involved in the expression of chemokine IL-8 and cytokine IL-6, an effect that can be inhibited by histamine receptor antagonists. Histamine 112-121 interleukin 6 Homo sapiens 71-75 32945158-16 2020 Furthermore, histamine enhances IL-1-induced IL-6 gene expression and protein synthesis via H2 receptors in peripheral monocytes. Histamine 13-22 interleukin 6 Homo sapiens 45-49 32691972-5 2020 Immunohistochemical analysis and qPCR revealed that topically applied curcumin either before, after or in combination with acidic bile exposure significantly suppressed its induced NF-kappaB activation in regenerating epithelial cells, and overexpression of Rela, Bcl2, Egfr, Stat3, Wnt5a, Tnf, Il6, Ptgs2. Curcumin 70-78 interleukin 6 Homo sapiens 295-298 32565333-10 2020 RESULTS: There was a significant decrease in the levels of PGE2, TNF-alpha, IL-6, and IFN-gamma in the ibuprofen group as compared to the non-ibuprofen group. Ibuprofen 103-112 interleukin 6 Homo sapiens 76-80 32622796-9 2020 Serum calcium levels were negatively correlated with leukocytes, CRP, PCT, IL-6 and D-dimer, while positively correlated with lymphocytes and ALB. Calcium 6-13 interleukin 6 Homo sapiens 75-79 32015430-6 2020 Mono-n-butyl phthalate (MBP) was correlated with higher IL-1beta, IL-6, and CRP expression in placentae of male fetuses and with higher IL-6, CRP, MCP-1, IL-8, IL-10, and CD68 expression in placentae of female fetuses. monobutyl phthalate 0-22 interleukin 6 Homo sapiens 66-70 32015430-6 2020 Mono-n-butyl phthalate (MBP) was correlated with higher IL-1beta, IL-6, and CRP expression in placentae of male fetuses and with higher IL-6, CRP, MCP-1, IL-8, IL-10, and CD68 expression in placentae of female fetuses. monobutyl phthalate 0-22 interleukin 6 Homo sapiens 136-140 32015430-6 2020 Mono-n-butyl phthalate (MBP) was correlated with higher IL-1beta, IL-6, and CRP expression in placentae of male fetuses and with higher IL-6, CRP, MCP-1, IL-8, IL-10, and CD68 expression in placentae of female fetuses. monobutyl phthalate 24-27 interleukin 6 Homo sapiens 66-70 32015430-6 2020 Mono-n-butyl phthalate (MBP) was correlated with higher IL-1beta, IL-6, and CRP expression in placentae of male fetuses and with higher IL-6, CRP, MCP-1, IL-8, IL-10, and CD68 expression in placentae of female fetuses. monobutyl phthalate 24-27 interleukin 6 Homo sapiens 136-140 32652260-0 2020 Iron promotes breast cancer cell migration via IL-6/JAK2/STAT3 signaling pathways in a paracrine or autocrine IL-6-rich inflammatory environment. Iron 0-4 interleukin 6 Homo sapiens 110-114 32652260-3 2020 In this study, we found that iron overload upregulated the inflammatory cytokine interleukin-6 (IL-6) expression to activate Janus Kinases 2/Signal Transducer and Activator of Transcription 3 (JAK2/STAT3) signaling in triple negative breast cancer (TNBC) MDA-MB-231 cell lines, resulting in epithelial-mesenchymal transition (EMT) and cancer cell migration, but it had no effects on the estrogen receptor (ER)-positive breast cancer MCF-7 cells. Iron 29-33 interleukin 6 Homo sapiens 81-94 32652260-3 2020 In this study, we found that iron overload upregulated the inflammatory cytokine interleukin-6 (IL-6) expression to activate Janus Kinases 2/Signal Transducer and Activator of Transcription 3 (JAK2/STAT3) signaling in triple negative breast cancer (TNBC) MDA-MB-231 cell lines, resulting in epithelial-mesenchymal transition (EMT) and cancer cell migration, but it had no effects on the estrogen receptor (ER)-positive breast cancer MCF-7 cells. Iron 29-33 interleukin 6 Homo sapiens 96-100 32652260-4 2020 However, in the presence of exogenous IL-6, iron overload could also dramatically induce an autocrine IL-6 loop in ER-positive MCF-7 cells to active IL-6/JAK2/STAT3 signaling, resulting in enhanced EMT and cell motility. Iron 44-48 interleukin 6 Homo sapiens 38-42 32652260-4 2020 However, in the presence of exogenous IL-6, iron overload could also dramatically induce an autocrine IL-6 loop in ER-positive MCF-7 cells to active IL-6/JAK2/STAT3 signaling, resulting in enhanced EMT and cell motility. Iron 44-48 interleukin 6 Homo sapiens 102-106 32652260-4 2020 However, in the presence of exogenous IL-6, iron overload could also dramatically induce an autocrine IL-6 loop in ER-positive MCF-7 cells to active IL-6/JAK2/STAT3 signaling, resulting in enhanced EMT and cell motility. Iron 44-48 interleukin 6 Homo sapiens 102-106 32652260-5 2020 In vivo animal studies also identified that iron overload promoted the progression of low metastatic breast cancer tumorigenicity and lung metastasis following the addition of exogenous IL-6. Iron 44-48 interleukin 6 Homo sapiens 186-190 32652260-6 2020 This study suggested that iron overload could result in inducible IL-6 expression leading to promote malignant transformation of breast cancer cells in an paracrine or autocrine IL-6-rich inflammatory environment. Iron 26-30 interleukin 6 Homo sapiens 66-70 32652260-6 2020 This study suggested that iron overload could result in inducible IL-6 expression leading to promote malignant transformation of breast cancer cells in an paracrine or autocrine IL-6-rich inflammatory environment. Iron 26-30 interleukin 6 Homo sapiens 178-182 32922141-7 2020 Treatment with cinnamaldehyde, tadalafil, or aliskiren reduced serum levels of rheumatoid factor, and pro-inflammatory cytokines; tumor necrosis factor-alpha and interleukin-6 (IL-6), along with elevated level of IL-10 which is an anti-inflammatory cytokine. Tadalafil 31-40 interleukin 6 Homo sapiens 162-175 31161863-8 2020 Moreover, both the serum levels of triglycerides and TC/HDL-C ratio showed a positive correlation with IL-6 CSF concentrations. Triglycerides 35-48 interleukin 6 Homo sapiens 103-107 32940965-11 2020 RESULTS: SnPP induced marked (~5-7x) increases in plasma IL-10 and IL-6 concentrations within 24-48 hr, and to equal degrees in HVs and CKD patients. S-Nitroso-N-propionyl-D,L-penicillamine 9-13 interleukin 6 Homo sapiens 67-71 32763516-7 2020 Moreover, treatment with IL-6 and IL-21, cytokines that induce WM cell proliferation and IgM secretion, increased gene expression of the amino acid transporters mediating glutathione metabolism, including ASCT2, SLC7A11 and 4F2HC, indicating that cytokines in the WM BM could modulate glutathione metabolism. Glutathione 171-182 interleukin 6 Homo sapiens 25-29 32763516-7 2020 Moreover, treatment with IL-6 and IL-21, cytokines that induce WM cell proliferation and IgM secretion, increased gene expression of the amino acid transporters mediating glutathione metabolism, including ASCT2, SLC7A11 and 4F2HC, indicating that cytokines in the WM BM could modulate glutathione metabolism. Glutathione 285-296 interleukin 6 Homo sapiens 25-29 32922141-0 2020 Aliskiren, tadalafil, and cinnamaldehyde alleviate joint destruction biomarkers; MMP-3 and RANKL; in complete Freund"s adjuvant arthritis model: Downregulation of IL-6/JAK2/STAT3 signaling pathway. Tadalafil 11-20 interleukin 6 Homo sapiens 163-167 32909001-6 2020 Notably, members of the TNF superfamily and IL-6 family were up-regulated in patients on oxygen support with severe and moderate disease. Oxygen 89-95 interleukin 6 Homo sapiens 44-48 31829070-10 2020 IL-6 levels among the MCD patients tested in this study were correlated with levels of albumin, hemoglobin, triglyceride, total cholesterol, C-reactive protein, fibrinogen and immunoglobulin G (Spearman"s correlation coefficient, r = 0.28-0.59). Triglycerides 108-120 interleukin 6 Homo sapiens 0-4 31829070-10 2020 IL-6 levels among the MCD patients tested in this study were correlated with levels of albumin, hemoglobin, triglyceride, total cholesterol, C-reactive protein, fibrinogen and immunoglobulin G (Spearman"s correlation coefficient, r = 0.28-0.59). Cholesterol 128-139 interleukin 6 Homo sapiens 0-4 32922141-7 2020 Treatment with cinnamaldehyde, tadalafil, or aliskiren reduced serum levels of rheumatoid factor, and pro-inflammatory cytokines; tumor necrosis factor-alpha and interleukin-6 (IL-6), along with elevated level of IL-10 which is an anti-inflammatory cytokine. Tadalafil 31-40 interleukin 6 Homo sapiens 177-181 32922141-12 2020 Collectively, these findings led to the assumption that the downregulation of IL-6/JAK2/STAT3 signaling by cinnamaldehyde, tadalafil, and aliskiren could alleviate joint destruction by MMP-3 and RANKL, reduce iNOS, and enhance eNOS expressions. Tadalafil 123-132 interleukin 6 Homo sapiens 78-82 33081905-12 2020 The possible mechanism is that metformin could inhibit cytokine storm via suppressing interleukin-6 (IL-6) signaling, prevent the process of lung fibrosis, suppress endocytosis, thereby elevating angiotensin converting enzyme 2 (ACE2) expression. Metformin 31-40 interleukin 6 Homo sapiens 101-105 33164356-4 2020 The results showed that adenosine, epigoitrin, chlorogenic acid, caffeic acid, cichoric acid, corynoline, baicalin, wogonoside, wogonin and oroxylin A had a certain regulatory effect on inflammatory factor tumor necrosis factor(TNF-alpha), interleukin(IL-1beta) and IL-6 at specific concentrations in a dose-dependent manner. Adenosine 24-33 interleukin 6 Homo sapiens 266-270 33081905-12 2020 The possible mechanism is that metformin could inhibit cytokine storm via suppressing interleukin-6 (IL-6) signaling, prevent the process of lung fibrosis, suppress endocytosis, thereby elevating angiotensin converting enzyme 2 (ACE2) expression. Metformin 31-40 interleukin 6 Homo sapiens 86-99 33164356-4 2020 The results showed that adenosine, epigoitrin, chlorogenic acid, caffeic acid, cichoric acid, corynoline, baicalin, wogonoside, wogonin and oroxylin A had a certain regulatory effect on inflammatory factor tumor necrosis factor(TNF-alpha), interleukin(IL-1beta) and IL-6 at specific concentrations in a dose-dependent manner. Chlorogenic Acid 47-63 interleukin 6 Homo sapiens 266-270 33164356-4 2020 The results showed that adenosine, epigoitrin, chlorogenic acid, caffeic acid, cichoric acid, corynoline, baicalin, wogonoside, wogonin and oroxylin A had a certain regulatory effect on inflammatory factor tumor necrosis factor(TNF-alpha), interleukin(IL-1beta) and IL-6 at specific concentrations in a dose-dependent manner. 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one 140-150 interleukin 6 Homo sapiens 266-270 33145215-12 2020 The level of IL-6 decreased significantly at the end of surgery compared to baseline in patients receiving sevoflurane (P = 0.040). Sevoflurane 107-118 interleukin 6 Homo sapiens 13-17 32375472-7 2020 Experimental results indicate that the limits of detection (LODs) of A-GFETs for detecting interleukin-6 (IL-6) and insulin can be significantly improved to be 618 fM and 766 fM respectively with applying electric field at -0.3V for 3h during PASE immobilization. Tritium 233-235 interleukin 6 Homo sapiens 91-104 32375472-7 2020 Experimental results indicate that the limits of detection (LODs) of A-GFETs for detecting interleukin-6 (IL-6) and insulin can be significantly improved to be 618 fM and 766 fM respectively with applying electric field at -0.3V for 3h during PASE immobilization. Tritium 233-235 interleukin 6 Homo sapiens 106-110 33145215-15 2020 The decrease in IL-6 level reflects anti-inflammatory effect and probable neuroprotective potential of propofol and sevoflurane. Sevoflurane 116-127 interleukin 6 Homo sapiens 16-20 32922544-9 2020 Moreover, surfactin could reduce Akt, mTOR, p65, and c-Jun activation and IL-6 secretion induced by PM. surfactin peptide 10-19 interleukin 6 Homo sapiens 74-78 32808031-9 2020 Thus, our findings suggest that tofacitinib is quite effective in protecting from colitis by inhibition of a bundle of T cell derived cytokines like IL-5, IL-6, IL-9, IL-13 and IL-17A. tofacitinib 32-43 interleukin 6 Homo sapiens 155-159 32847594-16 2020 Vitamin D might act as a strong immunosuppressant inhibiting cytokine release syndrome in COVID-19: Vitamin D: Suppression of key pro-inflammatory pathways including nuclear factor kappa B (NF-kB), interleukin-6 (IL-6), and tumor necrosis factor (TNF). Vitamin D 0-9 interleukin 6 Homo sapiens 198-211 32847594-16 2020 Vitamin D might act as a strong immunosuppressant inhibiting cytokine release syndrome in COVID-19: Vitamin D: Suppression of key pro-inflammatory pathways including nuclear factor kappa B (NF-kB), interleukin-6 (IL-6), and tumor necrosis factor (TNF). Vitamin D 0-9 interleukin 6 Homo sapiens 213-217 32847594-16 2020 Vitamin D might act as a strong immunosuppressant inhibiting cytokine release syndrome in COVID-19: Vitamin D: Suppression of key pro-inflammatory pathways including nuclear factor kappa B (NF-kB), interleukin-6 (IL-6), and tumor necrosis factor (TNF). Vitamin D 100-109 interleukin 6 Homo sapiens 213-217 33061910-6 2020 In particular, IL-6 has been involved in mediating the effects of MIA animal models in the offspring through actions on the placenta, induction of IL-17a, or triggering the decrease in non-heme iron (hypoferremia). Iron 194-198 interleukin 6 Homo sapiens 15-19 32922544-11 2020 Taken together, these results suggest that surfactin functions as a suppressor of PM-induced MMP2/9-dependent oral cancer cell migration and invasion by inhibiting the activation of phosphoinositide 3-kinase (PI3K)/Akt/mTOR and PI3K/Akt/nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1)/IL-6 signaling pathways. surfactin peptide 43-52 interleukin 6 Homo sapiens 302-306 32777949-8 2021 The IL-6 levels in the 5-FU + Vit-D group were also significantly lower than those in 5-FU. Fluorouracil 23-27 interleukin 6 Homo sapiens 4-8 32824523-5 2020 Moreover, ROS can stimulate the production of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) causing inflammation and cell death. Reactive Oxygen Species 10-13 interleukin 6 Homo sapiens 122-135 32824523-5 2020 Moreover, ROS can stimulate the production of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) causing inflammation and cell death. Reactive Oxygen Species 10-13 interleukin 6 Homo sapiens 137-141 32221587-9 2020 The highest absolute risks were observed among those with elevated levels of both cholesterol and inflammation [HR 6.4 (95% CI 2.9-14.1) for those in the top quartiles of baseline IL-6 and LDLC, HR 4.9 (95% CI 2.6-9.4) for those in the top quartiles of baseline hsCRP and LDLC, both P < 0.0001]. Cholesterol 82-93 interleukin 6 Homo sapiens 180-184 32806763-12 2020 RIH/glucose fluctuations also induced M1 polarization and an inflammatory profile (CD11c, IL-1beta, TNF-alpha, IL-6, and monocyte chemoattractant protein (MCP)-1) in macrophages. Glucose 4-11 interleukin 6 Homo sapiens 111-115 32821126-0 2020 Tumor-Derived Exosome-Educated Hepatic Stellate Cells Regulate Lactate Metabolism of Hypoxic Colorectal Tumor Cells via the IL-6/STAT3 Pathway to Confer Drug Resistance. Lactic Acid 63-70 interleukin 6 Homo sapiens 124-128 32764823-8 2020 Histamine increased the expression of H1R, H2R and H4R as well as of interleukin-6, cyclooxygenase-2, and prostaglandin-E2 secretion even without pressure application and induced receptor activator of NF-kB ligand (RANKL) protein expression with unchanged osteoprotegerin secretion. Histamine 0-9 interleukin 6 Homo sapiens 69-82 32821126-8 2020 Results: The expression of MCT1 and LDHB was high in the liver metastases of irinotecan-resistant patients, and the high level of IL-6 in the plasma of patients with CRLM was associated with poor response to irinotecan-based chemotherapy. Irinotecan 208-218 interleukin 6 Homo sapiens 130-134 32821126-10 2020 Furthermore, the conditioned medium of activated HSCs enhanced the lactate metabolism of hypoxic tumor cells by activating the IL-6/STAT3 pathway and upregulating the downstream MCT1 and LDHB, in order to confer the resistance of SN38, which is the active metabolite of irinotecan. Lactic Acid 67-74 interleukin 6 Homo sapiens 127-131 32821126-11 2020 Conclusion: Taken together, the cultured supernatant of normoxic exosome-educated HSCs enhances the lactate metabolism of hypoxic tumor cells via the IL-6/STAT3 pathway, in order to confer the SN38 resistance in a mimic liver metastatic microenvironment. Lactic Acid 100-107 interleukin 6 Homo sapiens 150-154 32710733-11 2020 The stimulation could occur by way of IL-6 / JAK2 / STAT3 / SOCS3 and NF-kappaB (p65)/IL-18, which work together to induce AKI and increase overall renal-related diagnostic markers, such as plasma creatinine and tubular cell damage. Creatinine 197-207 interleukin 6 Homo sapiens 38-42 32785678-8 2020 Results: Trehalose reduced the proinflammatory mediators TNF-alpha, IL-1beta, IL-6, and IL-8 in primary HCECs at 450 mOsM. Trehalose 9-18 interleukin 6 Homo sapiens 78-82 31902257-6 2020 The induction of 11beta-HSD1 by IL-1beta was further inducted by cortisol, whereas the induction of IL-1beta and IL-6 expression by IL-1beta was completely inhibited by cortisol. Hydrocortisone 169-177 interleukin 6 Homo sapiens 113-117 32305864-4 2020 Herein, we developed an in vivo electrochemical immunosensing device based on glassy carbon rod to simultaneously detect three proinflammatory cytokines (IL-1beta, IL-6 and TNF-alpha). Carbon 85-91 interleukin 6 Homo sapiens 164-168 32416368-14 2020 CONCLUSIONS: Results showed that maternal exposure to Li and Sr were associated with increased GWG, in which maternal IL-6 and GDF-15 could contribute to the associations between metal exposures and GWG in pregnant women. Metals 179-184 interleukin 6 Homo sapiens 118-122 31787367-7 2020 Obesity and diet composition were both positively associated to pro-inflammatory biomarkers, CRP and IL1b; while diet composition shared with physical activity levels the correlation with IL6 (positive with energy, fat, carbohydrate and saturated fatty acid intake, and negative with cholesterol intake and average physical activity in boys), NGF and glucose (in both cases correlations were negative with diet composition and physical activity variables) (P < 0.05, in all cases). Carbohydrates 220-232 interleukin 6 Homo sapiens 188-191 31787367-7 2020 Obesity and diet composition were both positively associated to pro-inflammatory biomarkers, CRP and IL1b; while diet composition shared with physical activity levels the correlation with IL6 (positive with energy, fat, carbohydrate and saturated fatty acid intake, and negative with cholesterol intake and average physical activity in boys), NGF and glucose (in both cases correlations were negative with diet composition and physical activity variables) (P < 0.05, in all cases). Fatty Acids 247-257 interleukin 6 Homo sapiens 188-191 31787367-7 2020 Obesity and diet composition were both positively associated to pro-inflammatory biomarkers, CRP and IL1b; while diet composition shared with physical activity levels the correlation with IL6 (positive with energy, fat, carbohydrate and saturated fatty acid intake, and negative with cholesterol intake and average physical activity in boys), NGF and glucose (in both cases correlations were negative with diet composition and physical activity variables) (P < 0.05, in all cases). Cholesterol 284-295 interleukin 6 Homo sapiens 188-191 31787367-7 2020 Obesity and diet composition were both positively associated to pro-inflammatory biomarkers, CRP and IL1b; while diet composition shared with physical activity levels the correlation with IL6 (positive with energy, fat, carbohydrate and saturated fatty acid intake, and negative with cholesterol intake and average physical activity in boys), NGF and glucose (in both cases correlations were negative with diet composition and physical activity variables) (P < 0.05, in all cases). Glucose 351-358 interleukin 6 Homo sapiens 188-191 31679041-8 2020 Melatonin supplementation significantly decreased TNF-alpha and IL-6 levels [(WMD = - 2.24 pg/ml; 95% CI - 3.45, - 1.03; P < 0.001; I2 = 96.7%, Pheterogeneity < 0.001) and (WMD = - 30.25 pg/ml; 95% CI - 41.45, - 19.06; P < 0.001, I2 = 99.0%; Pheterogeneity < 0.001)], respectively. Melatonin 0-9 interleukin 6 Homo sapiens 64-68 32724390-11 2020 The level of active ghrelin was positively correlated with that of IL-6 and energy metabolism (P=0.004 and 0.016, respectively) and negatively correlated with food intake rate (P=0.035), which suggests a state of ghrelin resistance. Ghrelin 20-27 interleukin 6 Homo sapiens 67-71 32504994-9 2020 In phorbol myristate acetate (PMA)-stimulated A549 or H292 airway epithelial cells, pretreatment of THCA dose-dependently inhibited the generation of IL-6. Tetradecanoylphorbol Acetate 3-28 interleukin 6 Homo sapiens 150-154 32504994-9 2020 In phorbol myristate acetate (PMA)-stimulated A549 or H292 airway epithelial cells, pretreatment of THCA dose-dependently inhibited the generation of IL-6. Tetradecanoylphorbol Acetate 30-33 interleukin 6 Homo sapiens 150-154 32454326-10 2020 We functionally challenged ovaries in vitro, by polyinosinic:polycytidylic acid (poly I:C) and LPS, known to activate TLR3 and TLR4, respectively, and found a tendency for increased IL-6 production, which was particular evident in the LPS-treated group. Poly I 81-87 interleukin 6 Homo sapiens 182-186 32227673-3 2020 Treatment with tomentosin (IC50 = 20 microM) significantly inhibited cell proliferation and oxidative stress-induced anti-cell proliferative (proliferating cell nuclear antigen and cyclin-D1) also regulated expression, drastically diminished tumor necrosis factor-alpha, nuclear factor-kappaB, interleukin-6, and interleukin-1beta expression levels, significantly upregulated Bcl-2 and Bax expression. tomentosin 15-25 interleukin 6 Homo sapiens 295-308 32724162-8 2020 Afterward, IL-6-JAK1-STAT3 signaling was demonstrated to promote SOX9 expression and invasion following ATP treatment. Adenosine Triphosphate 104-107 interleukin 6 Homo sapiens 11-15 32718086-4 2020 Results have been encouraging, particularly when anti-IL-6 has been used with other drugs, such as metothrexate (MTX). metothrexate 99-111 interleukin 6 Homo sapiens 54-58 32765941-5 2020 Since PGE2, LXA4 and their precursors AA (arachidonic acid), dihomo-gamma-linolenic acid (DGLA) and gamma-linolenic acid (GLA) inhibit the production of pro-inflammatory IL-6 and TNF-alpha, they could be employed to treat cytokine storm seen in COVID-19, immune check point inhibitory (ICI) therapy, sepsis and ARDS (acute respiratory disease). Dinoprostone 6-10 interleukin 6 Homo sapiens 170-174 32765941-5 2020 Since PGE2, LXA4 and their precursors AA (arachidonic acid), dihomo-gamma-linolenic acid (DGLA) and gamma-linolenic acid (GLA) inhibit the production of pro-inflammatory IL-6 and TNF-alpha, they could be employed to treat cytokine storm seen in COVID-19, immune check point inhibitory (ICI) therapy, sepsis and ARDS (acute respiratory disease). Arachidonic Acid 42-58 interleukin 6 Homo sapiens 170-174 32630717-3 2020 Hangover severity was significantly and positively correlated with blood concentrations of biomarkers of the inflammatory response to alcohol, in particular, Interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and C-reactive protein (CRP). Alcohols 134-141 interleukin 6 Homo sapiens 158-171 32559180-2 2020 Indeed, these changes in tryptophan metabolism correlated with interleukin-6 (IL-6) levels. Tryptophan 25-35 interleukin 6 Homo sapiens 63-76 32559180-2 2020 Indeed, these changes in tryptophan metabolism correlated with interleukin-6 (IL-6) levels. Tryptophan 25-35 interleukin 6 Homo sapiens 78-82 32559180-5 2020 Interestingly, metabolite levels in these pathways correlated with clinical laboratory markers of inflammation (i.e., IL-6 and C-reactive protein) and renal function (i.e., blood urea nitrogen).CONCLUSIONIn conclusion, this initial observational study identified amino acid and fatty acid metabolism as correlates of COVID-19, providing mechanistic insights, potential markers of clinical severity, and potential therapeutic targets.FUNDINGBoettcher Foundation Webb-Waring Biomedical Research Award; National Institute of General and Medical Sciences, NIH; and National Heart, Lung, and Blood Institute, NIH. Urea 179-183 interleukin 6 Homo sapiens 118-122 32559180-5 2020 Interestingly, metabolite levels in these pathways correlated with clinical laboratory markers of inflammation (i.e., IL-6 and C-reactive protein) and renal function (i.e., blood urea nitrogen).CONCLUSIONIn conclusion, this initial observational study identified amino acid and fatty acid metabolism as correlates of COVID-19, providing mechanistic insights, potential markers of clinical severity, and potential therapeutic targets.FUNDINGBoettcher Foundation Webb-Waring Biomedical Research Award; National Institute of General and Medical Sciences, NIH; and National Heart, Lung, and Blood Institute, NIH. Nitrogen 184-192 interleukin 6 Homo sapiens 118-122 32559180-5 2020 Interestingly, metabolite levels in these pathways correlated with clinical laboratory markers of inflammation (i.e., IL-6 and C-reactive protein) and renal function (i.e., blood urea nitrogen).CONCLUSIONIn conclusion, this initial observational study identified amino acid and fatty acid metabolism as correlates of COVID-19, providing mechanistic insights, potential markers of clinical severity, and potential therapeutic targets.FUNDINGBoettcher Foundation Webb-Waring Biomedical Research Award; National Institute of General and Medical Sciences, NIH; and National Heart, Lung, and Blood Institute, NIH. Fatty Acids 278-288 interleukin 6 Homo sapiens 118-122 31856585-9 2020 PGC-1alpha may act as selective repressor of phospho-p65 towards IL-6 in acute inflammation. phosphorylleucylphenylalanine 45-52 interleukin 6 Homo sapiens 65-69 32630717-4 2020 At 4 h after alcohol consumption, blood ethanol concentration (but not acetaldehyde) was significantly and positively associated with elevated levels of IL-6, suggesting a direct inflammatory effect of ethanol. Ethanol 40-47 interleukin 6 Homo sapiens 153-157 32630717-4 2020 At 4 h after alcohol consumption, blood ethanol concentration (but not acetaldehyde) was significantly and positively associated with elevated levels of IL-6, suggesting a direct inflammatory effect of ethanol. Ethanol 202-209 interleukin 6 Homo sapiens 153-157 33000107-8 2020 Inflammatory markers such as C-reactive protein, D-dimer, ferritin, fibrin degradation product and interleukin-6 were significantly elevated (P <0.05) in patients who required oxygen therapy than those who did not require it, suggesting the potential role such markers could play in predicting prognosis in patients. Oxygen 176-182 interleukin 6 Homo sapiens 99-112 32630207-5 2020 Here, we showed that ATRA prolongs the expression of IL-6 and IL-1beta following a 2-, 6-, 12-, and 24-h LPS (100ng/mL) activation in human monocyte-derived macrophages. Tretinoin 21-25 interleukin 6 Homo sapiens 53-57 32194233-5 2020 We demonstrated that dexamethasone in vitro given for 24 hours and followed by a 24-hour rest interval before an immune challenge potentiates inflammatory effects in these neural cells, that is, increases the IL-6 protein secretion induced by stimulation with IL-1beta (10ng/mL for 24 hours) by +49% (P<0.05) at a concentration of 100nM and by +70% (P<0.01) for 1muM. Dexamethasone 21-34 interleukin 6 Homo sapiens 209-213 32141941-6 2020 RESULTS: Pretreatment with 10 M DHT or 17-beta-estradiol inhibited the high osmolarity-induced expression of TNF-alpha, IL-8, and IL-6. Estradiol 39-56 interleukin 6 Homo sapiens 130-134 32447451-5 2020 RESULTS: Stimulation of cells by PMA or LPS (without Actovegin ) significantly increased the secretion of IL-1beta, IL-6, IL-10 and TNF-alpha from PBMCs, compared to controls. Tetradecanoylphorbol Acetate 33-36 interleukin 6 Homo sapiens 116-120 32388247-6 2020 Significant reduction in ROS and inflammatory cytokine production (i.e., IL-6, IL-1beta) was observed, including a reduction in ERK1/2 phosphorylation in neutrophils stimulated with LPS and fMLP in the presence of Fbln7-C compared to untreated controls. ros 25-28 interleukin 6 Homo sapiens 73-77 32801466-7 2020 ESG inhibited PM-induced expression of inflammatory cytokines IL6, TNFA and PTGS2. L-Gamma-Glutamyl-S-[(3s)-1-Ethyl-2,5-Dioxopyrrolidin-3-Yl]-L-Cysteinylglycine 0-3 interleukin 6 Homo sapiens 62-65 31913874-0 2020 Low levels of serum vitamin D in clozapine-treated schizophrenia patients are associated with high levels of the proinflammatory cytokine IL-6. Vitamin D 20-29 interleukin 6 Homo sapiens 138-142 31913874-8 2020 There was a significant inverse correlation between serum vitamin D and IL-6 levels (Pearson"s r = -0.38, P < 0.05). Vitamin D 58-67 interleukin 6 Homo sapiens 72-76 31913874-10 2020 These results suggest that within clozapine-treated schizophrenia patients, high levels of vitamin D are associated with lower serum levels of the proinflammatory cytokine IL-6. Vitamin D 91-100 interleukin 6 Homo sapiens 172-176 32361974-5 2020 The presence of NAC antagonized the ROS production, expressions of IRE1alpha and p-IRE1alpha; however, STF-083010 could decrease the expression levels of GRP78, XBP1, NF-kappaB, and p-NF-kappaB and attenuate IL-1beta, IL-6, TNF-alpha, VCAM-1, and ET-1 release induced by endosulfan. Acetylcysteine 16-19 interleukin 6 Homo sapiens 218-222 32537016-5 2020 In the present study, the results revealed that baicalin not only significantly alleviated TNBS-induced colitis by reducing the release of IL-6, TNF-alpha and IL-1beta and increasing the level of IL-10, but promoted the expression of tight-junction proteins ZO-1 and beta-catenin, which may have been achieved by blockage of the PI3K/AKT signaling pathway. Trinitrobenzenesulfonic Acid 91-95 interleukin 6 Homo sapiens 139-143 33680016-13 2020 Furthermore, Naringenin exhibited the capacity to suppress the function of IL-6 in modulating apoptosis-associated genes expression. naringenin 13-23 interleukin 6 Homo sapiens 75-79 32485058-6 2020 Paclitaxel induced overexpression of C-C motif chemokine ligand 2 (CCL2), tumour necrosis alpha (TNFalpha) and interleukin-6 (IL-6) in DRGs, where the presence of macrophages was demonstrated. Paclitaxel 0-10 interleukin 6 Homo sapiens 111-124 32485058-6 2020 Paclitaxel induced overexpression of C-C motif chemokine ligand 2 (CCL2), tumour necrosis alpha (TNFalpha) and interleukin-6 (IL-6) in DRGs, where the presence of macrophages was demonstrated. Paclitaxel 0-10 interleukin 6 Homo sapiens 126-130 32353742-2 2020 Like tocilizumab, Vitamin D appears to modulate the activity of an interleukin (IL-6), which may explain the seasonal variation in prevalence of influenza. Vitamin D 18-27 interleukin 6 Homo sapiens 80-84 32418885-5 2020 Interestingly, iron chelation has been shown in vitro to suppress endothelial inflammation in viral infection, which is the main pathophysiologic mechanism behind systemic organ involvement induced by SARS-CoV-2, by inhibiting IL-6 synthesis through decreasing NF-kB. Iron 15-19 interleukin 6 Homo sapiens 227-231 32753784-0 2020 Attenuation of core temperature elevation and interleukin-6 excretion during head-out hot water immersion in elderly people. Water 90-95 interleukin 6 Homo sapiens 46-59 32753784-2 2020 Recent studies have reported that 20 minutes of head-out immersion in hot water (42 C) increased serum interleukin-6 levels in young males. Water 74-79 interleukin 6 Homo sapiens 103-116 32753784-3 2020 This study aimed to compare the efficacy of head-out immersion in hot water (42 C) on serum interleukin-6 levels in seven elderly (66-75 years old) and eight young males (21-32 years old). Water 70-75 interleukin 6 Homo sapiens 92-105 32753784-7 2020 Serum interleukin-6 levels were significantly higher in young participants 1 hour after the head-out immersion in hot water (42 C); however, serum interleukin-6 levels did not change in elderly participants. Water 118-123 interleukin 6 Homo sapiens 6-19 32753784-9 2020 [Conclusion] The current study demonstrated that head-out immersion in hot water (42 C) more attenuated core temperature and interleukin-6 levels in elderly participants than in young participants. Water 75-80 interleukin 6 Homo sapiens 125-138 30886334-6 2020 The odds ratio for depression per standard deviation increase in genetically-predicted triglycerides was 1.18 (95% CI 1.09-1.27; p = 2 x 10-5); per unit increase in genetically-predicted log-transformed IL-6 was 0.74 (95% CI 0.62-0.89; p = 0.0012); and per unit increase in genetically-predicted log-transformed CRP was 1.18 (95% CI 1.07-1.29; p = 0.0009). Triglycerides 87-100 interleukin 6 Homo sapiens 203-207 32694786-7 2020 This correlates with their immunosuppressive phenotype: dimethyl itaconate and 4-octyl itaconate inhibited IkappaBzeta and pro-interleukin (IL)-1beta induction, as well as IL-6, IL-10 and interferon-beta secretion, in an NRF2-independent manner. dimethyl itaconate 56-74 interleukin 6 Homo sapiens 172-176 32377752-0 2020 Curcumin inhibits pancreatic cancer cell invasion and EMT by interfering with tumor-stromal crosstalk under hypoxic conditions via the IL-6/ERK/NF-kappaB axis. Curcumin 0-8 interleukin 6 Homo sapiens 135-139 32377752-15 2020 Curcumin also suppressed the secretion and expression of IL-6 in PSCs. Curcumin 0-8 interleukin 6 Homo sapiens 57-61 32377752-18 2020 Taken together, these data indicate that curcumin plays an important role in suppressing tumor-stromal crosstalk and pancreatic cancer metastasis by inhibiting the IL-6/ERK/NF-kappaB axis. Curcumin 41-49 interleukin 6 Homo sapiens 164-168 32377752-19 2020 Blocking the IL-6/ERK/NF-kappaB axis by curcumin may be a promising therapeutic strategy for the treatment of pancreatic cancer. Curcumin 40-48 interleukin 6 Homo sapiens 13-17 32387336-0 2020 Targeting androgen receptor in macrophages inhibits phosphate-induced vascular smooth muscle cell calcification by decreasing IL-6 expression. Phosphates 52-61 interleukin 6 Homo sapiens 126-130 32536965-14 2020 Second, the molecular docking results showed that there was a certain affinity between the core compounds (kaempferol, quercetin, 7-Methoxy-2-methyl isoflavone, naringenin, formononetin) and core target genes (IL6, IL1B, CCL2). naringenin 161-171 interleukin 6 Homo sapiens 210-213 32726040-5 2020 The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. Chlorogenic Acid 55-71 interleukin 6 Homo sapiens 253-257 32726040-5 2020 The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. Chlorogenic Acid 55-71 interleukin 6 Homo sapiens 342-346 32726040-5 2020 The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. Chlorogenic Acid 178-194 interleukin 6 Homo sapiens 253-257 32726040-5 2020 The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. Chlorogenic Acid 178-194 interleukin 6 Homo sapiens 342-346 32726040-5 2020 The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. linalool 199-207 interleukin 6 Homo sapiens 253-257 32726040-5 2020 The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. linalool 199-207 interleukin 6 Homo sapiens 342-346 32726040-5 2020 The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. Chlorogenic Acid 178-194 interleukin 6 Homo sapiens 253-257 32726040-5 2020 The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. Chlorogenic Acid 178-194 interleukin 6 Homo sapiens 342-346 32726040-6 2020 It revealed that the potential efficacy markers of Lonicerae Japonicae Flos in heat-clearing and detoxifying effect based on IL-1 signaling pathway were chlorogenic acid and linalool, and the potential efficacy markers of Lonicerae Japonicae Flos in heat-clearing and detoxifying effect based on IL-6 signaling pathway were chlorogenic acid and luteolin. lonicerae 51-60 interleukin 6 Homo sapiens 296-300 32500755-0 2021 Naringin inhibits titanium particles-induced up-regulation of TNF-alpha and IL-6 via the p38 MAPK pathway in fibroblasts from hip periprosthetic membrane. Titanium 18-26 interleukin 6 Homo sapiens 76-80 32500755-9 2021 RESULTS: Naringin or SB203580 pretreatment significantly suppressed the secretion of TNF-alpha and IL-6 induced by titanium particles in fibroblasts, while inhibition of ERK or JNK pathways showed no effect on production of TNF-alpha and IL-6. Titanium 115-123 interleukin 6 Homo sapiens 99-103 32632359-6 2020 ROS production can increase IL-6 production and lipid peroxidation resulting in cell damage. Reactive Oxygen Species 0-3 interleukin 6 Homo sapiens 28-32 32634713-5 2020 Our results demonstrate that breast cancer cells grown in 3D bone-mimetic scaffolds exhibited altered physiological and biochemical properties, including tumoroids formation, elevated levels of cytokine such as IL-6, and its downstream effector-mediated inhibition of apoptosis and upregulation of multidrug transporters proteins, leading to drug resistance against paclitaxel. Paclitaxel 366-376 interleukin 6 Homo sapiens 211-215 32496940-3 2022 After adjusting for clinical and demographic factors, ibuprofen users had significantly lower CRP levels (2.3 mg/L versus 3.5 mg/L, P = 0.04) and IL-6 levels (3.2 pg/ml versus 4.0 pg/ml, P = 0.04) compared to nonusers.Conclusions: Our study suggests that self-reported ibuprofen use may be negatively associated with CRP and IL-6 levels in chronic SCI after adjusting for known confounding factors, and suggests ibuprofen use may be an important, potential variable to consider in future studies focused on systemic inflammation in SCI. Ibuprofen 54-63 interleukin 6 Homo sapiens 146-150 32624703-0 2020 Berberine Inhibits Pro-inflammatory Cytokine-induced IL-6 and CCL11 Production via Modulation of STAT6 Pathway in Human Bronchial Epithelial Cells. Berberine 0-9 interleukin 6 Homo sapiens 53-57 32624703-10 2020 Berberine significantly inhibited the secretion of IL-6 and CCL11 from pro-inflammatory cytokine-activated BEAS-2B cells. Berberine 0-9 interleukin 6 Homo sapiens 51-55 32624703-13 2020 Current study reveals that berberine has inhibitory effect in pro-inflammatory cytokine-activated BEAS-2B cells through reducing IL-6 and CCL11 production, which is possibly modulated by suppressing STAT6 signaling pathway. Berberine 27-36 interleukin 6 Homo sapiens 129-133 32595496-7 2020 Concurrent neutralization of TNF-alpha, IL-1beta, and IL-6 with their antibodies provided better reduction in oxygen and glucose deprivation-induced increases in scar markers than obtained with separate use of each antibody. Oxygen 110-116 interleukin 6 Homo sapiens 54-58 32551386-6 2020 NAC-related increase in glutathione was associated with significant alterations in tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, IL-8 and IL-10 levels secreted in the culture medium. Acetylcysteine 0-3 interleukin 6 Homo sapiens 124-142 32551386-6 2020 NAC-related increase in glutathione was associated with significant alterations in tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, IL-8 and IL-10 levels secreted in the culture medium. Glutathione 24-35 interleukin 6 Homo sapiens 124-142 32551386-7 2020 A substantial decrease in the IL-6, IL-8 and TNF-alpha levels in the culture medium supplemented with NAC was obvious in hepatocytes recovered 14 days after differentiation. Acetylcysteine 102-105 interleukin 6 Homo sapiens 30-34 32516877-8 2020 These results indicated that CRAMP regulated the differentiation of VSMC by inhibiting ROS-mediated IL-6 autocrine, suggesting that targeting CRAMP is a potential avenue for regulating the differentiation of VSMC and treatment of atherosclerosis. Reactive Oxygen Species 87-90 interleukin 6 Homo sapiens 100-104 32496940-0 2022 Ibuprofen use is associated with reduced C-reactive protein and interleukin-6 levels in chronic spinal cord injury. Ibuprofen 0-9 interleukin 6 Homo sapiens 64-77 32496940-1 2022 Objective: To assess the association between ibuprofen use and the systemic inflammatory biomarkers C-reactive protein (CRP) and interleukin-6 (IL-6) in chronic Spinal Cord Injury (SCI).Study design: Prospective cohort study.Setting: Community dwelling individuals with SCI.Participants: 338 (278 male, 60 female) community dwelling individuals with chronic SCI (>=1-year post-injury).Interventions: None.Main outcome measures: CRP and IL-6 levels were quantified by ultra-sensitive ELISA assay. Ibuprofen 45-54 interleukin 6 Homo sapiens 129-142 32496940-3 2022 After adjusting for clinical and demographic factors, ibuprofen users had significantly lower CRP levels (2.3 mg/L versus 3.5 mg/L, P = 0.04) and IL-6 levels (3.2 pg/ml versus 4.0 pg/ml, P = 0.04) compared to nonusers.Conclusions: Our study suggests that self-reported ibuprofen use may be negatively associated with CRP and IL-6 levels in chronic SCI after adjusting for known confounding factors, and suggests ibuprofen use may be an important, potential variable to consider in future studies focused on systemic inflammation in SCI. Ibuprofen 54-63 interleukin 6 Homo sapiens 325-329 32496940-1 2022 Objective: To assess the association between ibuprofen use and the systemic inflammatory biomarkers C-reactive protein (CRP) and interleukin-6 (IL-6) in chronic Spinal Cord Injury (SCI).Study design: Prospective cohort study.Setting: Community dwelling individuals with SCI.Participants: 338 (278 male, 60 female) community dwelling individuals with chronic SCI (>=1-year post-injury).Interventions: None.Main outcome measures: CRP and IL-6 levels were quantified by ultra-sensitive ELISA assay. Ibuprofen 45-54 interleukin 6 Homo sapiens 144-148 32528731-0 2020 Interleukin-6 derived from cancer-associated fibroblasts attenuates the p53 response to doxorubicin in prostate cancer cells. Doxorubicin 88-99 interleukin 6 Homo sapiens 0-13 32528731-3 2020 We show that CAFs produce interleukin-6 (IL-6), and that IL-6 attenuates p53 induction and upregulation of the pro-apoptotic p53 target Bax upon treatment with doxorubicin. Doxorubicin 160-171 interleukin 6 Homo sapiens 57-61 32528731-5 2020 IL-6 also inhibited doxorubicin-induced cell death. Doxorubicin 20-31 interleukin 6 Homo sapiens 0-4 31610228-12 2020 CONCLUSION: Patients with alcohol overconsumption had a cytokine profile suggestive of increased systemic inflammatory activity, with higher levels of pro-inflammatory cytokines (IL-6, IFN-gamma and MCP-1) and lower levels of anti-inflammatory cytokines (TGF-beta1). Ethanol 26-33 interleukin 6 Homo sapiens 179-183 31815524-8 2020 Besides, VD reduced the contents of tumor necrosis factor-alpha and interleukin-6 both in cartilage tissues and in chondrocytes. Vitamin D 9-11 interleukin 6 Homo sapiens 68-81 31610228-8 2020 Patients with alcohol overconsumption had higher levels of IL-6 (p = 0.002), IFN-gamma (p = 0.018) and MCP-1 (p = 0.006), and lower levels of TGF-beta1 (p = 0.017) compared with control patients. Ethanol 14-21 interleukin 6 Homo sapiens 59-63 31840936-12 2020 Metformin or AICAR presence decreased spontaneous production of IL-6, IL-8 and MCP-1 in RA synovial explants and SFCs (n=5-7). Metformin 0-9 interleukin 6 Homo sapiens 64-68 32563931-2 2020 IL-6 is known as an exercise-inducible myokine, and in rodents it was identified that a lactate-dependent increase in protease activity mediates IL-6 release from skeletal muscle, which acts in both an autocrine and paracrine roles. Lactic Acid 88-95 interleukin 6 Homo sapiens 0-4 31792920-9 2020 High glucose increased the secretion of IL-6. Glucose 5-12 interleukin 6 Homo sapiens 40-44 31463762-7 2020 Inflammatory effects of ZnSO4 were investigated by measuring interleukin-6 (IL-6) levels and tumor necrosis factor-alpha (TNF-alpha) levels. Zinc Sulfate 24-29 interleukin 6 Homo sapiens 61-74 32563931-2 2020 IL-6 is known as an exercise-inducible myokine, and in rodents it was identified that a lactate-dependent increase in protease activity mediates IL-6 release from skeletal muscle, which acts in both an autocrine and paracrine roles. Lactic Acid 88-95 interleukin 6 Homo sapiens 145-149 32547185-13 2020 Dexamethasone 4 mg and 8 mg decreased the ratio IL-6/IL-10 (b=-2.60 (-3.93 to -1.26), P<0.001 and b=-3.59 (-5.04 to -2.13), P<0.001, respectively). Dexamethasone 0-13 interleukin 6 Homo sapiens 48-52 32053214-12 2020 Low concentration (0.05mM) ASA reduced inflammatory cytokines IL-6 (p < 0.001), CCL21 (P < 0.05) and MMP-9 (p < 0.05) in an ex vivo pulpitis model. Aspirin 27-30 interleukin 6 Homo sapiens 62-66 32068891-12 2020 IL-6 produced by macrophages in response to LPS- treated dentine impeded SCAP migration (p < 0.001), diminished on CSnp and Dex-CSnp conditioning groups (p < 0.01). Dexamethasone 127-130 interleukin 6 Homo sapiens 0-4 32485124-7 2020 Ang-II, IL-6, and TNF-alpha concentrations were all reduced after vitamin D supplementation. Vitamin D 66-75 interleukin 6 Homo sapiens 8-12 32069432-6 2020 MCP-1 and GM-CSF levels, as well as gene expressions of IL-6 and IL-8 in HTR8/SVneo cells were greatly increased by TNF-alpha (5, 10 and 20 ng/mL), but reversed by sevoflurane and SB203580. sevoflurane 164-175 interleukin 6 Homo sapiens 56-60 32469940-4 2020 In the present study carried out in whole blood, heparin and selectively desulfated heparin reduced histone induced inflammatory markers such as interleukin 6 (IL 6), interleukin 8 (IL 8) and tissue factor and C3a, a complement component. Heparin 49-56 interleukin 6 Homo sapiens 145-158 32469940-4 2020 In the present study carried out in whole blood, heparin and selectively desulfated heparin reduced histone induced inflammatory markers such as interleukin 6 (IL 6), interleukin 8 (IL 8) and tissue factor and C3a, a complement component. Heparin 49-56 interleukin 6 Homo sapiens 160-164 32469940-4 2020 In the present study carried out in whole blood, heparin and selectively desulfated heparin reduced histone induced inflammatory markers such as interleukin 6 (IL 6), interleukin 8 (IL 8) and tissue factor and C3a, a complement component. Heparin 84-91 interleukin 6 Homo sapiens 145-158 32469940-4 2020 In the present study carried out in whole blood, heparin and selectively desulfated heparin reduced histone induced inflammatory markers such as interleukin 6 (IL 6), interleukin 8 (IL 8) and tissue factor and C3a, a complement component. Heparin 84-91 interleukin 6 Homo sapiens 160-164 32463794-2 2020 Metformin is capable of suppressing one of the molecular triggers of the proinflammatory and prothrombotic processes of urban PM air pollution, namely the mitochondrial ROS/Ca2+ release-activated Ca2+ channels (CRAC)/IL-6 cascade. Metformin 0-9 interleukin 6 Homo sapiens 217-221 32463794-2 2020 Metformin is capable of suppressing one of the molecular triggers of the proinflammatory and prothrombotic processes of urban PM air pollution, namely the mitochondrial ROS/Ca2+ release-activated Ca2+ channels (CRAC)/IL-6 cascade. ros 169-172 interleukin 6 Homo sapiens 217-221 32463794-3 2020 Given the linkage between mitochondrial functionality, ion channels, and inflamm-aging, the ability of metformin to target mitochondrial electron transport and prevent ROS/CRAC-mediated IL-6 release might illuminate new therapeutic avenues to quell the raging of the cytokine and thrombotic-like storms that are the leading causes of COVID-19 morbidity and mortality in older people. Metformin 103-112 interleukin 6 Homo sapiens 186-190 32463794-3 2020 Given the linkage between mitochondrial functionality, ion channels, and inflamm-aging, the ability of metformin to target mitochondrial electron transport and prevent ROS/CRAC-mediated IL-6 release might illuminate new therapeutic avenues to quell the raging of the cytokine and thrombotic-like storms that are the leading causes of COVID-19 morbidity and mortality in older people. ros 168-171 interleukin 6 Homo sapiens 186-190 32064734-3 2020 The results showed that BCP and beta-TCP could support macrophages attachment, proliferation and spreading favorably, as well as promote gene expressions of inflammatory related cytokines (IL-1, IL-6, MCP-1 and TNF-alpha) and growth factors (TGF-beta, FGF, PDGF, VEGF, IGF and EGF). beta-tricalcium phosphate 32-40 interleukin 6 Homo sapiens 195-199 32615160-12 2020 In addition, combining bergenin and dexamethasone (DEX) yielded additive effects on the reduction of IL-6 and IL-8 expression. Dexamethasone 36-49 interleukin 6 Homo sapiens 101-105 32615160-12 2020 In addition, combining bergenin and dexamethasone (DEX) yielded additive effects on the reduction of IL-6 and IL-8 expression. Dexamethasone 51-54 interleukin 6 Homo sapiens 101-105 32019627-6 2020 Folate catabolite apABG was positively correlated with IL-6 (r= 0.27, plinear<0.0001) and pABG was positively correlated with IL-8 (r= 0.21, plinear<0.0001), indicating higher folate utilization during inflammation.Our data support the hypothesis of inverse associations between PLP and inflammatory biomarkers among colorectal cancer patients. Folic Acid 0-6 interleukin 6 Homo sapiens 55-59 32449901-11 2020 The production of TNF-alpha, IL-6, and IL-1ss was significantly suppressed by roflumilast. Roflumilast 78-89 interleukin 6 Homo sapiens 29-33 32434541-0 2020 Cisplatin treatment induced interleukin 6 and 8 production alters lung adenocarcinoma cell migration in an oncogenic mutation dependent manner. Cisplatin 0-9 interleukin 6 Homo sapiens 28-47 32528464-7 2020 Incubation of healthy and SSc dendritic cells with etoposide, a carnitine transporter inhibitor, inhibited the production of pro-inflammatory cytokines such as IL-6 through inhibition of fatty acid oxidation. Fatty Acids 187-197 interleukin 6 Homo sapiens 160-164 32448273-9 2020 In vivo studies suggested the topical application of TRA and BT dual-loaded liposomal gel had the best ability to reduce the thickness of epidermal and the level of cytokines (TNF-alpha and IL-6), largely alleviating the symptoms of psoriasis. Tretinoin 53-56 interleukin 6 Homo sapiens 190-194 31282535-10 2020 CONCLUSION: The association of low vitamin D with slow gait speed statistically interacts with high IL-6. Vitamin D 35-44 interleukin 6 Homo sapiens 100-104 32434541-11 2020 Cisplatin but not erlotinib increased both IL-6 and IL-8 secretion and only IL-6 increased cellular migration and proliferation. Cisplatin 0-9 interleukin 6 Homo sapiens 43-47 32775816-12 2020 In addition, endothelial changes mediated via interleukin (IL)-6 and vascular endothelial growth factor (VEGF) that lead to vascular hyperpermeability and water leakage might contribute to anasarca, because molecular-targeting therapy directed against IL-6 or VEGF improved renal dysfunction and severe endothelial damage. Water 155-160 interleukin 6 Homo sapiens 46-64 32336102-7 2020 With almost equal surface content of PSBMA, the PSBMA-PDA-PP exhibited a more superior ability against macrophages adhesion and proliferation, and showed more significantly decreased releases of TNF-alpha and IL-6 (p < 0.05) than those of PSBMA@PDA-PP, fundamentally attributed to its more neutral surface potential and the protection for polyphenols of PDA from oxidation with PSBMA as the outer-layer. pda-pp 54-60 interleukin 6 Homo sapiens 209-213 32429534-9 2020 Finally, NTS and MSM inhibited the high glucose-induced expression of interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha and binding of NF-kappaB protein to the DNA of proinflammatory cytokines. Glucose 40-47 interleukin 6 Homo sapiens 94-98 32518807-9 2020 After metformin treatment, expression of interleukin 6 (IL-6), TNF-alpha, and IL-1beta were significantly downregulated in RA-FLSs; however, increased expression of p-AMPK-alpha1, protein kinase A (PKA)-alpha1, and HAPLN1 (hyaluronan and proteoglycan link protein 1) was observed. Metformin 6-15 interleukin 6 Homo sapiens 41-54 32511571-0 2020 COVID-19 infection results in alterations of the kynurenine pathway and fatty acid metabolism that correlate with IL-6 levels and renal status. Fatty Acids 72-82 interleukin 6 Homo sapiens 114-118 32511571-6 2020 Indeed, the observed changes in tryptophan metabolism correlated with serum interleukin-6 (IL-6) levels. Tryptophan 32-42 interleukin 6 Homo sapiens 76-89 32511571-6 2020 Indeed, the observed changes in tryptophan metabolism correlated with serum interleukin-6 (IL-6) levels. Tryptophan 32-42 interleukin 6 Homo sapiens 91-95 32348149-3 2020 Benefiting from multi-enzyme activities against RONS, Rh-PEG NDs can decrease the levels of pro-inflammatory cytokines (TNF-alpha, IL-6), resulting in good anti-inflammatory effect on dextran sulfate sodium-induced colitis. rons 48-52 interleukin 6 Homo sapiens 131-135 32434116-0 2020 Corrigendum to "Rapamycin suppresses TLR4-triggered IL-6 and PGE2 production of colon cancer cells by inhibiting TLR4 expression and NF-kappaB activation" [Mol. Sirolimus 16-25 interleukin 6 Homo sapiens 52-56 32518807-9 2020 After metformin treatment, expression of interleukin 6 (IL-6), TNF-alpha, and IL-1beta were significantly downregulated in RA-FLSs; however, increased expression of p-AMPK-alpha1, protein kinase A (PKA)-alpha1, and HAPLN1 (hyaluronan and proteoglycan link protein 1) was observed. Metformin 6-15 interleukin 6 Homo sapiens 56-60 32206779-4 2020 We previously reported three anti-IL-6 non-responders with increased mTOR activation who responded to mTOR inhibition with sirolimus. Sirolimus 123-132 interleukin 6 Homo sapiens 34-38 32494176-11 2020 Furthermore, deficient 25(OH)D individuals with low HDL-C levels had higher circulatory IL-6 and IL-8 levels, and higher serum soluble TM compared to individuals with sufficient 25(OH)D and normal lipid profiles (median, IL-6 pg/mL 0.82 vs 1.71, P=0.001; median, IL-8 pg/mL 51.31 vs 145.6, P=0.003; and median, soluble TM ng/mL 5.19 vs 7.38, P<0.0001; in sufficient vs deficient groups, respectively). 25(oh)d 23-30 interleukin 6 Homo sapiens 88-92 32494176-11 2020 Furthermore, deficient 25(OH)D individuals with low HDL-C levels had higher circulatory IL-6 and IL-8 levels, and higher serum soluble TM compared to individuals with sufficient 25(OH)D and normal lipid profiles (median, IL-6 pg/mL 0.82 vs 1.71, P=0.001; median, IL-8 pg/mL 51.31 vs 145.6, P=0.003; and median, soluble TM ng/mL 5.19 vs 7.38, P<0.0001; in sufficient vs deficient groups, respectively). 25(oh)d 23-30 interleukin 6 Homo sapiens 221-225 32476816-9 2020 IL-1 beta, IL-2, IL-6, and TNF-alpha in tears and conjunctiva increased in the DESOS groups compared to the CMDE and control groups, indicating a high correlation with hypersensitivity status in the DESOS groups. desos 79-84 interleukin 6 Homo sapiens 17-21 31843406-8 2020 Additionally, let-7a, miR-146a-5p, and miR-155-5p were found to mediate the associations of BPDE-Alb adducts with IL-6 and/or TLR2 expression. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 92-96 interleukin 6 Homo sapiens 114-118 32370749-10 2020 Meanwhile, sinensetin treatment significantly decreased IAV-induced expression of pro-inflammatory mediators at mRNA and protein levels, including IL-6, TNF-alpha, IP-10, IL-8 and MCP-1. sinensetin 11-21 interleukin 6 Homo sapiens 147-151 32413063-5 2020 CSA demonstrated a significant negative correlation with IL-6 level (r = -0.28, p<0. Cyclosporine 0-3 interleukin 6 Homo sapiens 57-61 32413063-7 2020 Sobel test and bootstrapping revealed a significant mediating role for trust between CSA and IL-6 level. Cyclosporine 85-88 interleukin 6 Homo sapiens 93-97 32413063-10 2020 Trust played a mediating role between CSA and adulthood levels of IL-6. Cyclosporine 38-41 interleukin 6 Homo sapiens 66-70 32312819-4 2020 To explore this issue, we analyzed secretomes from glucose-deprived cells, which revealed up-regulation of multiple cytokines and chemokines, including IL-6 and IL-8, in response to starvation stress. Glucose 51-58 interleukin 6 Homo sapiens 152-156 32312819-7 2020 Furthermore, glutamine deprivation, as well as the antimetabolic drugs 2-deoxyglucose and metformin, also promoted the release of IL-6 and IL-8. Metformin 90-99 interleukin 6 Homo sapiens 130-134 32370298-10 2020 Further treatment of these macrophages with nicotine or HLE extracts caused higher inflammatory response (increased iNOS (M1), TNF-alpha, IL-6, and M1/M2 ratio, p < 0.05), increased MAP burden, and decreased apoptosis. Nicotine 44-52 interleukin 6 Homo sapiens 138-142 32275470-7 2020 Additionally, the upregulated expression of inflammatory cytokines, IL-6 and IL-8, after histamine stimulation was abolished by silencing Orai1 or STIM1 with RNAi in LECs. Histamine 89-98 interleukin 6 Homo sapiens 68-72 32523885-0 2020 Effects of conjugated linoleic acid supplementation on serum levels of interleukin-6 and sirtuin 1 in COPD patients. Linoleic Acid 22-35 interleukin 6 Homo sapiens 71-84 33073254-7 2020 As expected, DEX treatment suppressed multiple LPS-induced pro-inflammatory cytokines (IFN-gamma, IL-6, IL-8, IL-1beta, .TNF-alpha) by >85% and increased the anti-inflammatory cytokine IL-10 by 80%. Dexamethasone 13-16 interleukin 6 Homo sapiens 98-102 33073254-8 2020 Inhibiting Complex I potentiated DEX suppression of IL-6 by a further 12% (d = 0.73), indicating partial mitochondrial modulation of glucocorticoid sensitivity. Dexamethasone 33-36 interleukin 6 Homo sapiens 52-56 32205228-12 2020 Among obese participants (n = 108), benzene, lead, and cadmium were each positively associated with CK18 M30, IL-1beta, IL-6, and IL-8. Cadmium 55-62 interleukin 6 Homo sapiens 120-124 32124251-4 2020 Curcumin treatment inhibited the expression of the inflammation mediators IL-6, iNOS, and COX-2 and of the matrix-degrading proteinases MMP-1, MMP-3, MMP-9, MMP-13, ADAMTS-4, and ADAMTS-5 and upregulated the mRNA levels of the cartilage anabolic factors COL2A1 and ACAN after IL-1beta treatment. Curcumin 0-8 interleukin 6 Homo sapiens 74-78 32266020-6 2020 The percentage of maximal inhibition of IL-6 by DEX was presented as Emax. Dexamethasone 48-51 interleukin 6 Homo sapiens 40-44 32266020-11 2020 Moreover, IL-35 enhanced DEX-suppressed IL-6 production and the DEX-induced upregulation of the MKP-1 mRNA expression level in monocytes from both patient groups (P<0.01). Dexamethasone 25-28 interleukin 6 Homo sapiens 40-44 32179241-11 2020 Furthermore, a strong positive correlation was observed between the changes in the urine 8-iso-PGF2alpha , 8-OHdG levels and serum IL-6 levels in subjects from anthocyanin groups after 12 weeks of treatment. 8-epi-prostaglandin F2alpha 89-104 interleukin 6 Homo sapiens 131-135 32323738-8 2020 Furthermore, geniposide mitigated the ox-LDL-induced inflammatory response, demonstrated by a downregulation of pro-inflammatory cytokine (IL-1beta, IL-6, and TNF-alpha) levels and an upregulation of anti-inflammatory cytokine (IL-10) level. geniposide 13-23 interleukin 6 Homo sapiens 149-153 32387130-6 2020 GTS-21, an agonist for the alpha 7 nicotinic receptors (alpha7nAChR), was found to exert immune-modulatory actions in PBMCs of COPD patients by suppressing the production of IL-6 and NO. 3-(2,4-dimethoxybenzylidene)anabaseine 0-6 interleukin 6 Homo sapiens 174-178 31960917-6 2020 Pre-treating ARPE-19 cells with quercetin clearly attenuated high glucose-induced viability loss, apoptosis, MCP-1 and IL-6 overproduction, and ROS generation. Glucose 66-73 interleukin 6 Homo sapiens 119-123 32365773-5 2020 Treatment with sildenafil significantly reduced dermal fibroblast gene expression and cellular release of IL-6, known to play a central role in the pathogenesis of tissue damage in SSc and IL-8, directly induced by ROS. Reactive Oxygen Species 215-218 interleukin 6 Homo sapiens 106-110 32365859-2 2020 In peripheral tissues, exercise induced IL-6 can result in GLUT4 translocation and increased glucose uptake through AMPK activation. Glucose 93-100 interleukin 6 Homo sapiens 40-44 32365859-4 2020 The aim of this study is to examine if IL-6 treatment: (1) results in AMPK activation in neuronal cells, (2) increases the activation of proteins involved in GLUT4 translocation, and (3) increases neuronal glucose uptake. Glucose 206-213 interleukin 6 Homo sapiens 39-43 32365859-10 2020 Importantly, IL-6 treatment increased glucose uptake. Glucose 38-45 interleukin 6 Homo sapiens 13-17 32365859-11 2020 Our findings demonstrate that IL-6 and insulin can phosphorylate AS160 via different signaling pathways (AMPK and PI3K/Akt, respectively) and promote GLUT4 translocation towards the neuronal plasma membrane, resulting in increased neuronal glucose uptake in SH-SY5Y cells. Glucose 240-247 interleukin 6 Homo sapiens 30-34 32368126-0 2020 Nicotine-Free e-Cigarette Vapor Exposure Stimulates IL6 and Mucin Production in Human Primary Small Airway Epithelial Cells. Nicotine 0-8 interleukin 6 Homo sapiens 52-55 32349426-8 2020 In IBDs and, in particular, in celiac disease (CeD), IL-6 might trigger the expression, upregulation and secretion of hepcidin in the small intestine, reducing iron efflux and exacerbating defective iron absorption. Iron 160-164 interleukin 6 Homo sapiens 53-57 32349426-8 2020 In IBDs and, in particular, in celiac disease (CeD), IL-6 might trigger the expression, upregulation and secretion of hepcidin in the small intestine, reducing iron efflux and exacerbating defective iron absorption. Iron 199-203 interleukin 6 Homo sapiens 53-57 32322697-1 2020 Objectives: To evaluate effectiveness of a nasal resveratrol/carboxymethyl-beta-glucan solution compared to nasal saline solution: a) on common cold symptoms by means of a validated measure scale (CARIFS score), b) on Rhinovirus infection and CCL2, CCL5, IL8, IL6, CXCL10 and TLR2 expression in nasal swabs, c) on frequency of relapses after 30 days of follow-up. Resveratrol 49-60 interleukin 6 Homo sapiens 260-263 32313211-6 2021 Further, glutamate had extensive effects on gene expression in the mast cells, including the upregulation of pro-inflammatory components such as IL-6 and CCL2. Glutamic Acid 9-18 interleukin 6 Homo sapiens 145-149 32368126-7 2020 Results: Unlike the nicotine-containing e-vapor, nicotine-free e-vapor significantly increased the amount of IL6, which was coupled with increased levels of intracellular MUC5AC protein. Nicotine 49-57 interleukin 6 Homo sapiens 109-112 32368126-8 2020 Importantly, a neutralizing IL6 antibody (vs an IgG isotype control) significantly inhibited the production of MUC5AC induced by nicotine-free e-vapor. Nicotine 129-137 interleukin 6 Homo sapiens 28-31 31987922-0 2020 Doxorubicin-polyglycerol-nanodiamond conjugates disrupt STAT3/IL-6-mediated reciprocal activation loop between glioblastoma cells and astrocytes. Doxorubicin 0-24 interleukin 6 Homo sapiens 62-66 32296091-6 2020 There were significant correlations between baseline and one-year dialysis effluent IL-6 and COX-2 levels with the corresponding dialysate-to-plasma creatinine level at 4 hours (D/P4) and mass transfer area coefficient of creatinine (MTAC). Creatinine 149-159 interleukin 6 Homo sapiens 84-88 32296091-6 2020 There were significant correlations between baseline and one-year dialysis effluent IL-6 and COX-2 levels with the corresponding dialysate-to-plasma creatinine level at 4 hours (D/P4) and mass transfer area coefficient of creatinine (MTAC). Creatinine 222-232 interleukin 6 Homo sapiens 84-88 32296091-10 2020 Dialysis effluent IL-6 and COX-2 levels correlate with the concomitant D/P4 and MTAC of creatinine. Creatinine 88-98 interleukin 6 Homo sapiens 18-22 32004600-0 2020 Silencing of IL-6 and STAT3 by siRNA loaded hyaluronate-N,N,N-trimethyl chitosan nanoparticles potently reduces cancer cell progression. Nitrogen 56-71 interleukin 6 Homo sapiens 13-17 32004600-3 2020 In the present study, we generated the active-targeted hyaluronate (HA) recoated N, N, N-trimethyl chitosan (TMC) nanoparticles (NPs) to deliver IL-6- and STAT3-specific small interfering RNAs (siRNAs) to the CD44-expressing cancer cells. Nitrogen 81-82 interleukin 6 Homo sapiens 145-149 32004600-3 2020 In the present study, we generated the active-targeted hyaluronate (HA) recoated N, N, N-trimethyl chitosan (TMC) nanoparticles (NPs) to deliver IL-6- and STAT3-specific small interfering RNAs (siRNAs) to the CD44-expressing cancer cells. Nitrogen 84-85 interleukin 6 Homo sapiens 145-149 31987922-6 2020 Next, we showed that doxorubicin-polyglycerol-nanodiamond conjugates (Nano-DOX), which could be delivered via GBM-associated macrophages, suppressed STAT3 activity in the GBC reducing their IL-6 output to the astrocytes and thereby abolished the astrocytes" feedback activation of the GBC. Doxorubicin 21-45 interleukin 6 Homo sapiens 190-194 31987922-6 2020 Next, we showed that doxorubicin-polyglycerol-nanodiamond conjugates (Nano-DOX), which could be delivered via GBM-associated macrophages, suppressed STAT3 activity in the GBC reducing their IL-6 output to the astrocytes and thereby abolished the astrocytes" feedback activation of the GBC. Doxorubicin 75-78 interleukin 6 Homo sapiens 190-194 32290188-7 2020 In vitro validation experiments revealed that co-incubation with lactate and pyruvate enhances IL-10 production and attenuates the release of pro-inflammatory IL-1beta and IL-6 by LPS-stimulated leukocytes. Lactic Acid 65-72 interleukin 6 Homo sapiens 172-176 31987922-7 2020 Moreover, Nano-DOX also suppressed stimulated activation of STAT3 and IL-6 induced by temozolomide, a first-line anti-GBM chemotherapy, resistance to which critically involves STAT3 activation. Doxorubicin 15-18 interleukin 6 Homo sapiens 70-74 31987922-8 2020 In conclusion, Nano-DOX could disrupt the STAT3/IL-6-mediated reciprocal activation loop between the GBC and astrocytes. Doxorubicin 20-23 interleukin 6 Homo sapiens 48-52 30986119-4 2020 IL-6 and MMP-9 were significantly decreased in both groups at 12 weeks.Conclusions: Both nanoemulsion and conventional cyclosporin A improved ocular signs, symptoms, and conjunctival inflammation. Cyclosporine 119-132 interleukin 6 Homo sapiens 0-4 31489628-6 2020 RESULTS: ELS was not associated with the magnitude of change in IL-6 from pre- to post-vaccine, however, exposure to ELS moderated the association between change in IL-6 from pre- to post-vaccine and changes in both cognitive difficulty and depressed mood. N-[(2S,3S,4R)-3,4-dihydroxy-8-oxo-8-[(4-pentylphenyl)amino]-1-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}octan-2-yl]hexacosanamide 117-120 interleukin 6 Homo sapiens 165-169 31383995-0 2020 Sertraline treatment decreased the serum levels of interleukin-6 and high-sensitivity C-reactive protein in hematopoietic stem cell transplantation patients with depression; a randomized double-blind, placebo-controlled clinical trial. Sertraline 0-10 interleukin 6 Homo sapiens 51-64 31987921-5 2020 Mitochondrial Lon induces ROS-dependent production of inflammatory cytokines, such as TGF-beta, IL-6, IL-13, and VEGF-A, which consequently activates EMT, angiogenesis, and M2 macrophage polarization. Reactive Oxygen Species 26-29 interleukin 6 Homo sapiens 96-100 32172522-9 2020 A noticeable reduction was recorded in inflammatory biomarkers (cytokines) in the vitamin D-treated group (IL-6 p = 0.08, TNF-alpha p = 0.02, IL-2 p = 0.36) with notable elevation in IFN-gamma (p = 0.65) compared to the control group. Vitamin D 82-91 interleukin 6 Homo sapiens 107-111 32062076-6 2020 Besides, Cap attenuated APAP-induced overproduction and release of proinflammatory mediators like TNF-alpha, IL-1beta, IL-17A, IL-6, and MCP-1. cap 9-12 interleukin 6 Homo sapiens 127-131 31264496-10 2020 Further, treatment of patient-derived macrophages with rapamycin, an autophagy inducer agent, successfully regulated the production of LDL, IL-6, TNF-alpha, and ApoB expression via activation of autophagosome formation. Sirolimus 55-64 interleukin 6 Homo sapiens 140-144 32145664-6 2020 We illustrate these approaches using data from the Russia ARCH (Alcohol Research Collaboration on HIV/AIDS) study to analyze the association between alcohol consumption and biomarker of systemic inflammation, interleukin-6 (IL-6). Alcohols 149-156 interleukin 6 Homo sapiens 209-222 32145664-6 2020 We illustrate these approaches using data from the Russia ARCH (Alcohol Research Collaboration on HIV/AIDS) study to analyze the association between alcohol consumption and biomarker of systemic inflammation, interleukin-6 (IL-6). Alcohols 149-156 interleukin 6 Homo sapiens 224-228 30448438-9 2020 Moreover, CSF IL-6 levels were strongly negatively correlated with CSF glucose and the CSF/blood glucose ratio (r = -0.4375, P = 0.0042; r = -0.4991, P = 0.0009). Glucose 71-78 interleukin 6 Homo sapiens 14-18 31410973-6 2020 IL 6 induced STAT3 activation during chronic inflammation and Th17 development suppressed by Zn via attenuating this activation critically controls Th17-cell development. Zinc 93-95 interleukin 6 Homo sapiens 0-4 30448438-9 2020 Moreover, CSF IL-6 levels were strongly negatively correlated with CSF glucose and the CSF/blood glucose ratio (r = -0.4375, P = 0.0042; r = -0.4991, P = 0.0009). Glucose 97-104 interleukin 6 Homo sapiens 14-18 30448438-11 2020 Furthermore, we observed negative correlations between CSF IL-6 levels and CSF glucose and CSF/blood glucose ratio in CNS infection. Glucose 79-86 interleukin 6 Homo sapiens 59-63 31764462-9 2020 Variations in the resting concentration of IL-6 were associated with lowered blood glucose, an increased perception of effort, and impaired exercise performance. Glucose 83-90 interleukin 6 Homo sapiens 43-47 30448438-11 2020 Furthermore, we observed negative correlations between CSF IL-6 levels and CSF glucose and CSF/blood glucose ratio in CNS infection. Glucose 101-108 interleukin 6 Homo sapiens 59-63 32347005-6 2020 RESULTS: The CRP and IL-6 levels were lower in the TXA + DEX group than in the TXA group (all P < 0.001) at 24 h, 48 h, and 72 h postoperatively. Dexamethasone 57-60 interleukin 6 Homo sapiens 21-25 32337262-8 2020 In addition, by GSEA, expression of CXCL1, CXCL11, CXCL2, and CXCL3 was correlated with several signaling pathways, including NOD-like receptor, oxidative phosphorylation, mTORC1, interferon-gamma response, and IL6/JAK/STAT3 pathways. gsea 16-20 interleukin 6 Homo sapiens 211-214 32289862-0 2020 Heparanase Facilitates PMA-Induced Megakaryocytic Differentiation in K562 Cells via Interleukin 6/STAT3 Pathway. Tetradecanoylphorbol Acetate 23-26 interleukin 6 Homo sapiens 84-97 32289862-5 2020 Analysis of a series of megakaryocytic differentiation-related heparin-binding proteins (HBPs) in the cell culture medium revealed an exclusive positive correlation between the level of interleukin 6 (IL-6) and HPSE expression. Heparin 63-70 interleukin 6 Homo sapiens 186-199 32289862-5 2020 Analysis of a series of megakaryocytic differentiation-related heparin-binding proteins (HBPs) in the cell culture medium revealed an exclusive positive correlation between the level of interleukin 6 (IL-6) and HPSE expression. Heparin 63-70 interleukin 6 Homo sapiens 201-205 32258099-12 2020 Further study revealed that metformin may attenuate the phosphorylation of the Stat3 and the Bcl-2 expression, which was restored by IL-6 partly in EC109 cells but not HEECs. Metformin 28-37 interleukin 6 Homo sapiens 133-137 32041779-4 2020 PolyP up-regulated LPS-induced production of the inflammatory cytokines, such as tumor necrosis factor alpha, interleukin-1beta, and interleukin-6, in macrophages, and the effect was polyP dose- and chain length-dependent. Polyphosphates 183-188 interleukin 6 Homo sapiens 133-146 32280713-4 2020 Results: We found that, with the elevation of glucose, the level of H2S was decreased in GDM pregnant women and newborns and the concentrations of IL-6 and TNF-alpha were upregulated. Glucose 46-53 interleukin 6 Homo sapiens 147-151 32280713-5 2020 With regression, IL-6 and TNF-alpha concentrations were positively correlated with the level of blood glucose and negatively correlated with H2S concentration. Glucose 102-109 interleukin 6 Homo sapiens 17-21 32258115-7 2020 With the cotreatment with LPS, which could boost the expression of cytokines in these cancer cells, berberine significantly reduced the increased expression of TNF-alpha and IL-6. Berberine 100-109 interleukin 6 Homo sapiens 174-178 32218789-9 2020 IC87114 also attenuated poly I:C-induced increases in numbers of total cells, macrophages, neutrophils and lymphocytes, as well as levels of KC, IL-6 and MIP-1beta in bronchoalveolar lavage fluid. Carbon 1-2 interleukin 6 Homo sapiens 145-149 31919136-11 2020 CONCLUSIONS: The inflammatory cytokine IL6 may be predictive of therapeutic benefit from bevacizumab when combined with carboplatin and paclitaxel. Paclitaxel 136-146 interleukin 6 Homo sapiens 39-42 31930970-3 2020 In primary cultured bone marrow-derived macrophages (BMDMs), SalB attenuated lipopolysaccharide (LPS)-induced M1 biomarkers (IL-6, iNOS, CCL2 and TNF-alpha) mRNA expression in a concentration-dependent manner. salvianolic acid B 61-65 interleukin 6 Homo sapiens 125-129 32032644-0 2020 Honokiol: A polyphenol neolignan ameliorates pulmonary fibrosis by inhibiting TGF-beta/Smad signaling, matrix proteins and IL-6/CD44/STAT3 axis both in vitro and in vivo. Lignans 23-32 interleukin 6 Homo sapiens 123-127 32218789-13 2020 IC87114 decreased poly I:C-induced PD-L1 expression on PBECs and secretion of IL-6 and IL-8 into culture supernatants. Poly I 18-24 interleukin 6 Homo sapiens 78-82 32218789-13 2020 IC87114 decreased poly I:C-induced PD-L1 expression on PBECs and secretion of IL-6 and IL-8 into culture supernatants. Carbon 1-2 interleukin 6 Homo sapiens 78-82 32139669-4 2020 In vitro, both knockdown of TRPC6 expression with shRNA and TRPC6 blockage markedly attenuated the release of cytokines IL-6 and IL-8 induced by O3 or H2O2 in 16HBE cells (human bronchial epithelial cell line). Ozone 145-147 interleukin 6 Homo sapiens 120-124 32005665-8 2020 In hypoxia mimicked by treating MDM with oligomycin (a mitochondrial ATP synthase inhibitor), both 2-DG and glucose starvation strongly suppress TNF and interleukin-6 production, and compromise cell viability. Glucose 108-115 interleukin 6 Homo sapiens 153-166 32164364-5 2020 In SiONPs-stimulated NCI-H292 airway epithelial cells, silibinin treatment effectively suppressed the elevation of the mRNA expression of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, and IL-1beta, which was accompanied by the reduction in the expression of TXNIP, MAPKs, and activator protein-1 (AP-1). Silybin 55-64 interleukin 6 Homo sapiens 179-197 32210815-2 2020 Methanolic extracts of spent coffee grounds obtained from 3 Arabica cultivars possess compounds that exerted inhibitory effects on the secretion of inflammatory mediators (TNF-alpha, IL-6, and IL-10) induced by a human pro-monocytic cell line differentiated with PMA and stimulated with lipopolysaccharide (LPS). methanolic 0-10 interleukin 6 Homo sapiens 183-187 32139669-4 2020 In vitro, both knockdown of TRPC6 expression with shRNA and TRPC6 blockage markedly attenuated the release of cytokines IL-6 and IL-8 induced by O3 or H2O2 in 16HBE cells (human bronchial epithelial cell line). Hydrogen Peroxide 151-155 interleukin 6 Homo sapiens 120-124 30975555-5 2020 RESULTS: Circulating IL-6 levels decreased after glucose and protein ingestion but slightly increased after oral lipid intake. Glucose 49-56 interleukin 6 Homo sapiens 21-25 33081432-0 2020 The Effect of Melatonin on the Serum Level of Interleukin 6 and Interleukin 9 in Coronary Artery Bypass Grafting Surgery. Melatonin 14-23 interleukin 6 Homo sapiens 46-59 33081432-2 2020 The aim of this study was to investigate the effect of melatonin on the serum levels of interleukin 6 (IL-6) and IL-9 in patients undergoing coronary artery bypass grafting surgery. Melatonin 55-64 interleukin 6 Homo sapiens 88-101 33081432-2 2020 The aim of this study was to investigate the effect of melatonin on the serum levels of interleukin 6 (IL-6) and IL-9 in patients undergoing coronary artery bypass grafting surgery. Melatonin 55-64 interleukin 6 Homo sapiens 103-107 33081432-7 2020 RESULTS: The mean serum level of IL-6 was significantly lower in the melatonin group at T3 and T4 (p < 0.05). Melatonin 69-78 interleukin 6 Homo sapiens 33-37 33081432-10 2020 CONCLUSION: The results of this study showed that pre-operative melatonin administration could modify inflammatory cytokines secretion such as IL-6 while it has no significant effect on the serum levels of IL- 9. Melatonin 64-73 interleukin 6 Homo sapiens 143-147 32064872-4 2020 In porcine intestinal epithelial cells (IPEC-J2), L-arginine obviously suppressed (p < 0.05) the levels of IL-6 (220.63 +- 2.82), IL-8 (333.95 +- 3.75), IL-1beta (693.08 +- 2.38) and TNF-alpha (258.04 +- 4.14) induced by LPS. Arginine 50-60 interleukin 6 Homo sapiens 110-114 31944871-7 2020 Serum IL-6 exhibited significant inverse correlations with body mass index (r = -0.39/P < 0.0001), waist circumference (r = -0.42/P < 0.001), blood glucose (r = -0.40/P < 0.0001), triglycerides (r = -0.34/P < 0.0001), and TNF-alpha (r = -0.48/P < 0.0001), whereas a strongly positive correlation was found with IL-10 (r = 0.77/P < 0.0001). Glucose 154-161 interleukin 6 Homo sapiens 6-10 31864122-5 2020 CML up-regulated both the gene expression of RAGE, the activating protein-1 (AP-1), the inflammatory cytokines Interleukin-6 (IL-6), vascular cell adhesion molecule1 (VCAM-1), monocyte chemotactic protein1 (MCP-1). Nepsilon-Dansyl-L-lysine 0-3 interleukin 6 Homo sapiens 111-124 31864122-5 2020 CML up-regulated both the gene expression of RAGE, the activating protein-1 (AP-1), the inflammatory cytokines Interleukin-6 (IL-6), vascular cell adhesion molecule1 (VCAM-1), monocyte chemotactic protein1 (MCP-1). Nepsilon-Dansyl-L-lysine 0-3 interleukin 6 Homo sapiens 126-130 31758423-9 2020 IGU, MTX, and DXM dose dependently decreased the secretion of TNF-alpha, IL-1beta, IL-6, and IL-8 in neutrophils and PBMCs (P < 0.05); the inhibitory effect of IGU was not significantly different from that of MTX and DXM. Dexamethasone 14-17 interleukin 6 Homo sapiens 83-87 32383705-15 2020 As it was established the amount of bacteria producing short-chain fatty acids (SCFA) markedly decrease in T2-D, and treatment with SCFA reduced induction of TFN-alpha, IL-10 and IL-17 cytokines in contrast to IL-6, IFN-y and IL-22, without modification of their induction after using of SCFA. Fatty Acids, Volatile 132-136 interleukin 6 Homo sapiens 210-214 32383705-15 2020 As it was established the amount of bacteria producing short-chain fatty acids (SCFA) markedly decrease in T2-D, and treatment with SCFA reduced induction of TFN-alpha, IL-10 and IL-17 cytokines in contrast to IL-6, IFN-y and IL-22, without modification of their induction after using of SCFA. Fatty Acids, Volatile 132-136 interleukin 6 Homo sapiens 210-214 31944871-7 2020 Serum IL-6 exhibited significant inverse correlations with body mass index (r = -0.39/P < 0.0001), waist circumference (r = -0.42/P < 0.001), blood glucose (r = -0.40/P < 0.0001), triglycerides (r = -0.34/P < 0.0001), and TNF-alpha (r = -0.48/P < 0.0001), whereas a strongly positive correlation was found with IL-10 (r = 0.77/P < 0.0001). Triglycerides 189-202 interleukin 6 Homo sapiens 6-10 31818575-8 2020 Aromatics content contributed to more significant PAH-mediated IL-6 downregulation, whereas ethanol content was associated with decreased downregulation of IL-6. Ethanol 92-99 interleukin 6 Homo sapiens 156-160 32071459-12 2020 Real-time PCR showed that 1-100 mumol/L meloxicam or 100 mumol/L aspirin down-regulated significantly the mRNA expression of TNF-alpha and IL-6 of LPS-hDPCs (P<0.05), and 100 mumol/L meloxicam down-regulated IL-6 and TNF-alpha more significantly than 100 mumol/L aspirin of LPS-hDPCs (P<0.05). Aspirin 65-72 interleukin 6 Homo sapiens 139-143 32107363-13 2020 Moreover, curcumin pre-treatment significantly decreased expression levels of Wnt5a, IL6, TNFalpha, and phosphorylation level of JNK1, as well as the nuclear translocation level of NF-kappaB in H/R-exposed neurons, in a concentration-dependent manner. Curcumin 10-18 interleukin 6 Homo sapiens 85-88 32106058-8 2020 We also found a decrease in the levels of IL-1beta, IL-6, IL-17, and IL-23 cytokines in the culture supernatant of digoxin treated PBMCs isolated from RA patients. Digoxin 115-122 interleukin 6 Homo sapiens 52-56 32109994-7 2020 Additionally, SZC achieved the anti-inflammatory activity by the cooperation of the compounds through inhibiting NO and IL-6, both promoting and inhibiting IL-10. sodium zirconium cyclosilicate 14-17 interleukin 6 Homo sapiens 120-124 31836142-5 2020 Furthermore, treatment with the JNK agonist anisomycin enhanced the damage to the joint cartilage and increased the levels of IL-1beta, IL-6 and TNF-alpha. Anisomycin 44-54 interleukin 6 Homo sapiens 136-140 32103032-8 2020 The mTORC1 inhibitor rapamycin also reduced IL-6 and IL-13 production, which would be consistent with a model in which MK2/3 regulate IL-6 and IL-13 via mTORC1 activation in ILC2s. Sirolimus 21-30 interleukin 6 Homo sapiens 44-48 32103032-8 2020 The mTORC1 inhibitor rapamycin also reduced IL-6 and IL-13 production, which would be consistent with a model in which MK2/3 regulate IL-6 and IL-13 via mTORC1 activation in ILC2s. Sirolimus 21-30 interleukin 6 Homo sapiens 134-138 32071459-12 2020 Real-time PCR showed that 1-100 mumol/L meloxicam or 100 mumol/L aspirin down-regulated significantly the mRNA expression of TNF-alpha and IL-6 of LPS-hDPCs (P<0.05), and 100 mumol/L meloxicam down-regulated IL-6 and TNF-alpha more significantly than 100 mumol/L aspirin of LPS-hDPCs (P<0.05). Aspirin 65-72 interleukin 6 Homo sapiens 211-215 32056400-14 2020 CONCLUSION: RA patients treated with IL-6 antibody show a better response when they have sufficient serum vit D. Vitamin D 106-111 interleukin 6 Homo sapiens 37-41 31823669-8 2020 IL-6 acts as an anti-inflammatory myokine by inhibiting TNF-alpha and improving glucose uptake through the stimulation of AMPK signaling. Glucose 80-87 interleukin 6 Homo sapiens 0-4 31560043-8 2020 Tofacitinib modulated the responses of activated monocytes toward a regulatory phenotype through reduced TNFalpha and IL-6 secretion and enhanced Treg induction in cocultures. tofacitinib 0-11 interleukin 6 Homo sapiens 118-122 32127934-0 2020 Mesenchymal stem/stromal cells-derived IL-6 promotes nasopharyngeal carcinoma growth and resistance to cisplatin via upregulating CD73 expression. Cisplatin 103-112 interleukin 6 Homo sapiens 39-43 32075287-11 2020 The use of curcumin reduces the subjective perception of the intensity of muscle pain; reduces muscle damage through the decrease of creatine kinase (CK); increases muscle performance; has an anti-inflammatory effect by modulating the pro-inflammatory cytokines, such as TNF-alpha, IL-6, and IL-8; and may have a slight antioxidant effect. Curcumin 11-19 interleukin 6 Homo sapiens 282-286 32046214-5 2020 Statistically significant higher plasma levels of IL-6, while lower TNFalpha, were detected in workers with cortisol >10 ng/mL. Hydrocortisone 108-116 interleukin 6 Homo sapiens 50-54 32014916-9 2020 Following IL-6 neutralization, phospho-STAT3 activation, cancer cell viability and migration, as well as EMT, and stemness of cancer cells decreased. phosphorylleucylphenylalanine 31-38 interleukin 6 Homo sapiens 10-14 31837588-11 2020 BBR (25 uM) treatment in LPS-HDPF could ameliorate cell inflammatory response, presented by reduced expressions of IL-1beta, IL-6 and TNF-alpha, as well as enhanced cell proliferation and miR-21 expression. Berberine 0-3 interleukin 6 Homo sapiens 125-129 31549730-9 2020 Both IL-1beta and IL-6 responses were augmented by extracellular ADP or ADP-betaS and were abrogated by PSB0739. Adenosine Diphosphate 65-68 interleukin 6 Homo sapiens 18-22 31735734-0 2020 Benzoylaconitine inhibits production of IL-6 and IL-8 via MAPK, Akt, NF-kappaB signaling in IL-1beta-induced human synovial cells. benzoylaconine 0-16 interleukin 6 Homo sapiens 40-44 31836387-5 2020 Eukaryotic transcriptome sequencing and western blot analysis demonstrated that 1,3-DCQA binds to 14-3-3tau to prevent breast cancer proliferation and metastasis via Jak/PI3K/Akt and Raf/ERK pathway, which promote IL6 and CSF3 expression raised by CREB (CREBBP, CREB5) and induced cell apoptosis via Bad/Bax/caspase 9 signaling pathway. 3,5-dicaffeoylquinic acid 80-88 interleukin 6 Homo sapiens 214-217 31328788-7 2020 OSM and also IL-6 were up-regulated by histamine at protein level. Histamine 39-48 interleukin 6 Homo sapiens 13-17 31631328-6 2020 Moreover, it was observed that nicotine decreases the production of interleukin (IL)-6 and C-C chemokine ligand (CCL)5 during Mtb infection in epithelial cells (EpCs), whereas in macrophages derived from human monocytes (MDMs) there is a decrease in IL-8, IL-6, tumor necrosis factor (TNF)-alpha, IL-10, CCL2, C-X-C chemokine ligand (CXCL)9 and CXCL10 only during infection with Mtb. Nicotine 31-39 interleukin 6 Homo sapiens 256-260 31448433-5 2020 Upadacitinib (and tofacitinib) reversibly inhibited IL-6-induced pSTAT3 and IL-7-induced pSTAT5 in a concentration-dependent manner. tofacitinib 18-29 interleukin 6 Homo sapiens 52-56 31876196-11 2020 BPA increased HLA-DR on moDCs of pSS patients via ERalpha, and promoted the secretion of IL6 and IL12. bisphenol A 0-3 interleukin 6 Homo sapiens 89-92 31448433-2 2020 This study characterizes the relationships between upadacitinib exposure and interleukin (IL)-6-induced signal transducer and activator of transcription proteins 3 (STAT3) phosphorylation (pSTAT3) and IL-7-induced STAT5 phosphorylation (pSTAT5) in the ex vivo setting as measures for JAK1 and JAK1/JAK3 inhibition, respectively, with comparison to tofacitinib. tofacitinib 348-359 interleukin 6 Homo sapiens 77-95 32245324-8 2020 TGF-beta increased the mRNA expression of IL-6 (p=0.02 and p=0.001) and TNF-alpha (p =0.014 and p = 0.001) in a time-dependent manner, ROS production (p=0.03) and Smad2L phosphorylation (p=0.015). Reactive Oxygen Species 135-138 interleukin 6 Homo sapiens 42-46 32245324-9 2020 Pre-treatment with curcumin, DPI and NAC inhibited TGF-beta-induced IL-6 (p=0.04) and TNF-alpha (p=0.001) mRNA expression, Smad2L phosphorylation (p=0.02) and ROS production (0.03). Curcumin 19-27 interleukin 6 Homo sapiens 68-72 32245324-10 2020 Pharmacological inhibition by Curcumin blocks TGF-beta-induced ROS production, Smad2L phosphorylation, and IL-6 and TNF-alpha mRNA expression in human VSMCs. Curcumin 30-38 interleukin 6 Homo sapiens 107-111 32461931-11 2020 In addition, compared with clopidogrel, tegrel can significantly inhibit the expression of IL-6 in patients with ACS and better alleviate the inflammatory response after PCI. tegrel 40-46 interleukin 6 Homo sapiens 91-95 31545524-10 2020 Significant reduction in IL-6 was seen with three-weekly paclitaxel-carboplatin (from median 81.3 [range 8.6, 1006] pg/mL to 51.8 [11.4, 99.5] pg/mL; P = .025). Paclitaxel 57-79 interleukin 6 Homo sapiens 25-29 31448433-6 2020 Model-estimated values of 50% of the maximum effect were 60.7 nM for upadacitinib and 119 nM for tofacitinib for IL-6-induced pSTAT3 inhibition, and 125 nM for upadacitinib and 79.1 nM for tofacitinib for IL-7-induced pSTAT5 inhibition. tofacitinib 97-108 interleukin 6 Homo sapiens 113-117 31448433-6 2020 Model-estimated values of 50% of the maximum effect were 60.7 nM for upadacitinib and 119 nM for tofacitinib for IL-6-induced pSTAT3 inhibition, and 125 nM for upadacitinib and 79.1 nM for tofacitinib for IL-7-induced pSTAT5 inhibition. tofacitinib 189-200 interleukin 6 Homo sapiens 113-117 31448433-7 2020 Tofacitinib 5 mg BID is estimated to have a similar magnitude of effect on IL-6-induced pSTAT3 to ~3 mg BID of upadacitinib (immediate-release formulation), whereas a 4-fold higher dose of upadacitinib (~12 mg BID), is estimated to show a similar magnitude of inhibition on IL-7-induced pSTAT5 as tofacitinb 5 mg BID. tofacitinib 0-11 interleukin 6 Homo sapiens 75-79 31974603-8 2020 Furthermore, MeDIP and RT-qPCR analysis demonstrated that the 5-methylcytosine levels of the IL-6 and TNF receptor-associated factor 6 (TRAF6) promoters were significantly decreased in DNMT1-deficient hDPCs. bathophenanthroline 13-18 interleukin 6 Homo sapiens 93-97 31821933-6 2020 The results have shown that the effect of proinflammatory IL-6 and TNF- cytokines results in the strongest production of the acute phase proteins in the first day on the Mg1Zn1Mn0.3 Zr-5 wt.% HA-1 wt. Zinc 170-178 interleukin 6 Homo sapiens 58-62 31821933-6 2020 The results have shown that the effect of proinflammatory IL-6 and TNF- cytokines results in the strongest production of the acute phase proteins in the first day on the Mg1Zn1Mn0.3 Zr-5 wt.% HA-1 wt. Zirconium 182-184 interleukin 6 Homo sapiens 58-62 31949017-9 2020 Interleukin-6 in acute and chronic inflammation, increases hepcidin levels causing iron-restricted erythropoiesis and anemia of inflammation in the presence of iron replete macrophages. Iron 83-87 interleukin 6 Homo sapiens 0-13 32237476-3 2020 The results showed that compared with MTX alone, Tripterygium Glycosides Tablets combined with MTX could further reduce the expression levels of peripheral blood TNF-alpha(SMD=-8.88,95%CI[-10.77,-6.99],P<0.000 01),IL-1beta(P<0.000 01) and IL-6(SMD=-8.63, 95%CI[-10.57,-6.69], P<0.000 01) in RA patients. tripterygium glycosides 49-72 interleukin 6 Homo sapiens 239-243 33329788-8 2020 Results: Curcumin attenuated expression of TNF-alpha, IL-6, and IL-8 and the phosphorylation levels of p38 and JNK, but not ERK1/2, in LPS-stimulated neutrophils. Curcumin 9-17 interleukin 6 Homo sapiens 54-58 31949017-9 2020 Interleukin-6 in acute and chronic inflammation, increases hepcidin levels causing iron-restricted erythropoiesis and anemia of inflammation in the presence of iron replete macrophages. Iron 160-164 interleukin 6 Homo sapiens 0-13 32005799-4 2020 Sevoflurane increases the level of serum IL-6, which activates STAT3 and the infiltration of CD11b+ myeloid cells into the lung. sevoflurane 0-11 interleukin 6 Homo sapiens 41-45 32076422-5 2020 Morphine-exposure of RM-PBMCs infected with SHIVs 4NF-kappaB, 3NF-kappaB, and AD8EO altered cellular transcript levels of monocyte chemoattractant protein 1, interleukin 6, interleukin 1beta, and Tumor Necrosis Factor alpha. Morphine 0-8 interleukin 6 Homo sapiens 158-171 32089648-8 2020 Therefore, CD154 is a potent early stimulus for IL-6 secretion by TECs in O2 deprivation conditions, a mechanism likely to take part in the deleterious inflammatory consequences of platelet activation in kidney tubular injury. Oxygen 74-76 interleukin 6 Homo sapiens 48-52 32005799-5 2020 Interruption of IL-6/JAK/STAT3 pathway by a JAK inhibitor AZD1480 reverses the pro-metastatic effect of sevoflurane and the associated increase of both activated STAT3 and infiltrated CD11b+ cells in 4T1 model. sevoflurane 104-115 interleukin 6 Homo sapiens 16-20 32010134-3 2019 Here we report that the response to c-di-AMP includes a post-transcriptional component that is involved in the induction of additional inflammatory cytokines including IL-6, CXCL2, CCL3, and CCL4. Cyclic AMP 36-44 interleukin 6 Homo sapiens 168-172 31973719-9 2020 IL-24 treatment reduced the number of apoptotic cells (0.5x, p < 0.05) and decreased the expression of inflammatory factors, including IL1A, IL6 and TNF of H2O2-treated FHs74Int cells. Water 159-163 interleukin 6 Homo sapiens 144-147 31979221-6 2020 An up to 60-fold higher formation of steroid hormones and their sulfated or glucuronidated metabolites was observed in carboplatin-sensitive cells, which was reversible by treatment with interleukin-6 (IL-6). Steroids 37-44 interleukin 6 Homo sapiens 187-200 31979221-6 2020 An up to 60-fold higher formation of steroid hormones and their sulfated or glucuronidated metabolites was observed in carboplatin-sensitive cells, which was reversible by treatment with interleukin-6 (IL-6). Steroids 37-44 interleukin 6 Homo sapiens 202-206 31979221-7 2020 Conversely, treatment of carboplatin-resistant cells expressing high levels of endogenous IL-6 with the monoclonal anti-IL-6R antibody tocilizumab changed their status to "platinum-sensitive", exhibiting a decreased IC50 value for carboplatin, decreased growth, and significantly higher estrogen metabolism. Platinum 172-180 interleukin 6 Homo sapiens 90-94 31969555-10 2020 Our findings demonstrate that IL-6 plays a pivotal role in the pathophysiology of paclitaxel-induced neuropathy per se and that pharmacological or genetic interference with this signaling pathway prevents the development of this potentially debilitating adverse effect. Paclitaxel 82-92 interleukin 6 Homo sapiens 30-34 31969555-11 2020 These findings provide a rationale for a clinical trial with IL-6 neutralizing antibodies to prevent dose-limiting neurotoxic adverse effects of paclitaxel chemotherapy. Paclitaxel 145-155 interleukin 6 Homo sapiens 61-65 31923274-6 2020 Markers of tryptophan degradation by the kynurenine pathway (kynurenine/tryptophan ratio) and activation of vitamin B6 catabolism (pyridoxic acid/(pyridoxal + pyridoxal 5"-phosphate), PAr index) differed in survivors with or without CF and correlated with known markers of immune activation and inflammation, such as neopterin, C-reactive protein and Interleukin-6. Tryptophan 11-21 interleukin 6 Homo sapiens 351-364 31947962-5 2020 Local intravaginal delivery of curcumin nanoparticles, but not intraperitoneal or oral delivery, reduced CpG-mediated inflammatory histopathology and decreased production of pro-inflammatory cytokines Interleukin (IL)-6, Tumor Necrosis Factor Alpha (TNF-alpha) and Monocyte Chemoattractant Protein-1 (MCP-1) in the FGT. Curcumin 31-39 interleukin 6 Homo sapiens 201-219 31629555-0 2020 Corrigendum to "Oroxylin A inhibits ATRA-induced IL-6 expression involved in retinoic acid syndrome by down-regulating CHOP" [Gene 551 (2014) 230-235]. 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one 16-26 interleukin 6 Homo sapiens 49-53 31629555-0 2020 Corrigendum to "Oroxylin A inhibits ATRA-induced IL-6 expression involved in retinoic acid syndrome by down-regulating CHOP" [Gene 551 (2014) 230-235]. Tretinoin 36-40 interleukin 6 Homo sapiens 49-53 31797394-0 2020 Significance of Markers of Monocyte Activation (CD163 and sCD14) and Inflammation (IL-6) in Patients Admitted for Alcohol Use Disorder Treatment. Alcohols 114-121 interleukin 6 Homo sapiens 83-87 31797394-9 2020 Alcohol consumption upon admission, MCV, total cholesterol levels, and CRP >5 mg/l (aORs: 0.99, 1.05, 0.99, and 2.56, respectively) were associated with IL-6. Alcohols 0-7 interleukin 6 Homo sapiens 153-157 31797394-9 2020 Alcohol consumption upon admission, MCV, total cholesterol levels, and CRP >5 mg/l (aORs: 0.99, 1.05, 0.99, and 2.56, respectively) were associated with IL-6. Cholesterol 47-58 interleukin 6 Homo sapiens 153-157 31935741-8 2020 Meanwhile, serum AEA levels correlated positively with serum interleukin-6, and negatively with serum very low-density lipoprotein levels. N,N,N-trimethyl-N'-cholesteryl amidoethyl ammonium 17-20 interleukin 6 Homo sapiens 61-74 33268714-0 2020 Muscarinic Acetylcholine Receptors Modulate Interleukin-6 Production and Immunoglobulin Class Switching in Daudi Cells. Acetylcholine 11-24 interleukin 6 Homo sapiens 44-57 31483910-8 2020 RESULTS: After treatment with resveratrol, it was found that serum levels of IL-6, IL-1beta, TNF-alpha, IL-18, NF-kappaB, and CRP decreased in treatment group. Resveratrol 30-41 interleukin 6 Homo sapiens 77-81 32115981-9 2020 RESULTS: Methamphetamine, in very low dose (pM), increased the cell viability and NO production, and decreased cell cytotoxicity, IL-1alpha, IL-1beta, IL-6, INFgamma, and TNFalpha pre-inflammatory cytokines of JEG-3 cell which were exposed to high dose of nicotine, respectively. Methamphetamine 9-24 interleukin 6 Homo sapiens 151-155 31626971-9 2020 Paradoxically, morphine increased the concentration of interleukin-6, granzyme A, and granzyme B in cell supernatants. Morphine 15-23 interleukin 6 Homo sapiens 55-68 31626971-10 2020 Pretreatment of NK cells with TAK-242 prevented the morphine-induced increase in interleukin-6, whereas pretreatment with naloxone inhibited the morphine-induced increase in granzymes A and B. Morphine 52-60 interleukin 6 Homo sapiens 81-94 31455510-6 2020 Levels of interleukin (IL)-6, IL-8, and macrophage chemotactic protein 1 (MCP-1) in the cerebrospinal fluid were high at onset and reduced transiently after steroid pulse therapy. Steroids 157-164 interleukin 6 Homo sapiens 10-28 31678680-0 2020 Native and iron-saturated bovine lactoferrin differently hinder migration in a model of human glioblastoma by reverting epithelial-to-mesenchymal transition-like process and inhibiting interleukin-6/STAT3 axis. Iron 11-15 interleukin 6 Homo sapiens 185-198 30596263-8 2020 The majority of the studies (five out of eight) found association of vitamin D status with biomarkers of oxidative stress and inflammation such as C-reactive protein (CRP), interleukin-6 (IL-6), cathepsin S, vascular cell adhesion molecule-1 (VCAM-1), malondialdehyde (MDA), myeloperoxidase, 3-nitrotyrosine, and superoxide dismutase (SOD). Vitamin D 69-78 interleukin 6 Homo sapiens 173-186 31812878-5 2020 RESULTS: While on placebo, sICAM-1, sVCAM-1, and cathepsin D significantly increased by 60 min post-METH infusion, while IL-6 significantly increased 360 min post-METH infusion. Methamphetamine 163-167 interleukin 6 Homo sapiens 121-125 32769032-8 2020 RESULTS: Metformin showed maximum percent declined from baseline to three months therapy in levels of fructosamine, beta-amyloid, sRAGE, inflammatory cytokines (IL-6, TNF-alpha) and percent increment in esRAGE and antioxidants levels. Metformin 9-18 interleukin 6 Homo sapiens 161-165 31475901-3 2020 In the case of MCD, it was observed that IL-6 is overproduced from T-cells and macrophage which disturbs Hepcidin, a vital regulator of iron trafficking in macrophage. Iron 136-140 interleukin 6 Homo sapiens 41-45 31442679-7 2020 In the correlation analysis, albumin/creatinine ratio was significantly and positively correlated with IP-10/CXCL10, MCP-1/CCL2, MIG/CXCL9, IL-8/CXCL8, TNF, IL-10, and IL-6. Creatinine 37-47 interleukin 6 Homo sapiens 168-172 32238143-7 2020 The immunmodulatory effects of the active metabolite of vitamin D (alpha-25 (OH)2D3) on the production of NO, IL-6, IL-10, TGF-beta and s-CTLA-4 was assessed by Griess method and ELISA, in peripheral blood mononuclear cells (PBMCs) of Algerian MetS patients and HC. Vitamin D 56-65 interleukin 6 Homo sapiens 110-114 31608988-4 2020 Here, we report that deoxyguanosine (dG) triggered cytokine production in murine bone marrow derived macrophages and plasmacytoid dendritic cells, as well as in human peripheral blood mononuclear cells, including type I interferons (IFNs) and pro-inflammatory factors such as TNF and IL-6. Deoxyguanosine 21-35 interleukin 6 Homo sapiens 284-288 31711017-9 2020 Positive associations of maternal urinary cadmium with %CD3+CD4+ cells, interleukin-4 (IL-4), and IL-6 were only observed among females, although there were no significant interactions. Cadmium 42-49 interleukin 6 Homo sapiens 98-102 32143964-6 2020 BA also has a positive impact on other areas of psychological health (e.g., self-efficacy, anxiety, and distress) and physical health (e.g., interleukin-6) in family dementia caregivers. Barium 0-2 interleukin 6 Homo sapiens 141-154 31657968-3 2020 The cascade starts with iron accumulation leading to an increase in CD68+ and CD11b+ cells responsible for initiating the inflammation.Areas covered: During inflammation, different factors and cytokines such as interleukin 1 (IL-1), IL-6, and tumor necrosis factor alpha (TNF-alpha) actively play parts in the pathogenesis of HA and also angiogenesis. Iron 24-28 interleukin 6 Homo sapiens 233-237 32139353-12 2020 RESULTS: The KYN/TRP ratio correlated positively with IL-6 and CD56bright NK-cells and negatively with CD56dim NKcells. Tryptophan 17-20 interleukin 6 Homo sapiens 54-58 30843768-5 2020 Treatment with alpha-tocopherol (10, 100, and 1,000 muM) and ascorbic acid (15, 150, and 1,500 muM) at the same time that the dextrose was added reduced IL-1beta, IL-6, and IL-8 levels in culture media from cells maintained at 5.5 mM dextrose but had no effect on IL-1beta, IL-6, and IL-8 levels in cells exposed to 27.5 mM dextrose. Glucose 126-134 interleukin 6 Homo sapiens 163-167 30843768-5 2020 Treatment with alpha-tocopherol (10, 100, and 1,000 muM) and ascorbic acid (15, 150, and 1,500 muM) at the same time that the dextrose was added reduced IL-1beta, IL-6, and IL-8 levels in culture media from cells maintained at 5.5 mM dextrose but had no effect on IL-1beta, IL-6, and IL-8 levels in cells exposed to 27.5 mM dextrose. Glucose 126-134 interleukin 6 Homo sapiens 274-278 31781916-9 2020 Inhibition of SIRT1 via EX-527 diminished the beneficial effects of IL-6 pretreatment. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 24-30 interleukin 6 Homo sapiens 68-72 31942180-5 2020 Activation of IL-6/STAT3/HIF-1alpha signaling was found to promote EMT and chemoresistance to Doxorubicin in vitro and in vivo by regulating SNAI1. Doxorubicin 94-105 interleukin 6 Homo sapiens 14-18 31714645-0 2020 Bisphenol A triggers the malignancy of acute myeloid leukemia cells via regulation of IL-4 and IL-6. bisphenol A 0-11 interleukin 6 Homo sapiens 95-99 31714645-4 2020 Among the tested cytokines, BPA treatment can decrease the expression of interleukin-4 (IL-4) while increasing the expression of IL-6. bisphenol A 28-31 interleukin 6 Homo sapiens 129-133 31714645-5 2020 Overexpression of IL-4 or neutralization antibody of IL-6 (anti-IL-6) can attenuate BPA-induced proliferation of AML cells and reverse BPA-suppressed chemosensitivity. bisphenol A 84-87 interleukin 6 Homo sapiens 53-57 31714645-5 2020 Overexpression of IL-4 or neutralization antibody of IL-6 (anti-IL-6) can attenuate BPA-induced proliferation of AML cells and reverse BPA-suppressed chemosensitivity. bisphenol A 84-87 interleukin 6 Homo sapiens 59-68 31714645-5 2020 Overexpression of IL-4 or neutralization antibody of IL-6 (anti-IL-6) can attenuate BPA-induced proliferation of AML cells and reverse BPA-suppressed chemosensitivity. bisphenol A 135-138 interleukin 6 Homo sapiens 53-57 31714645-5 2020 Overexpression of IL-4 or neutralization antibody of IL-6 (anti-IL-6) can attenuate BPA-induced proliferation of AML cells and reverse BPA-suppressed chemosensitivity. bisphenol A 135-138 interleukin 6 Homo sapiens 59-68 31714645-6 2020 Furthermore, activation of nuclear factor kappa B is essential for BPA-induced upregulation of IL-6 in AML cells. bisphenol A 67-70 interleukin 6 Homo sapiens 95-99 31714645-8 2020 Collectively, our data showed that BPA can trigger the malignancy of AML cells via regulation of IL-4 and IL-6. bisphenol A 35-38 interleukin 6 Homo sapiens 106-110 31791492-5 2020 Moreover, 1 mug/mL to 10 mug/mL carbon particle treatments disrupted the keratinocyte differentiation, and up-regulated inflammation- and psoriasis-related genes, such as IL-1beta, IL-6, CXCL1, CXCL2, CXCL3, CCL20, CXCL8, and S100A7 and S100A9, respectively. Carbon 32-38 interleukin 6 Homo sapiens 181-185 33162505-6 2020 Moreover, IL-6 upregulates the production of hepcidin, the master regulator of systemic iron metabolism, in the liver. Iron 88-92 interleukin 6 Homo sapiens 10-14 32441198-3 2020 In addition, serum levels of TNF-alpha, IL-1beta, IL-6, IL-8, and tumor marker CEA were decreased significantly in omega-3, vitamin D, and co-supplementation of them, compared with baseline. Vitamin D 124-133 interleukin 6 Homo sapiens 50-54 31574409-14 2020 Furthermore, IL-6 concentration appeared to increase across DII quartiles calculated from FFQ in men. dilC18(3) dye 60-63 interleukin 6 Homo sapiens 13-17 33860776-3 2020 RESULTS: The literature reports that vitamin D has immunomodulatory and anti-inflammatory effects.It reduces the expression of cytokines such as IL-6, TNF-alpha and INF-gamma, regulates the activity of T helper lymphocytes, and other elements of the immune system at the molecular level. Vitamin D 37-46 interleukin 6 Homo sapiens 145-149 30262241-0 2020 Corrigendum to "CO-releasing molecules CORM2 attenuates angiotensin II-induced human aortic smooth muscle cell migration through inhibition of ROS/IL-6 generation and matrix metalloproteinases-9 expression" [Redox Biol. ros 143-146 interleukin 6 Homo sapiens 147-151 31287731-5 2020 Results: Obesity increased the expression of proliferative signaling including COX-2, IL-6, AKT, ERK, and AR, which was attenuated with silibinin. Silybin 136-145 interleukin 6 Homo sapiens 86-90 32966919-0 2020 Effects of vitamin D supplementation on core symptoms, serum serotonin, and interleukin-6 in children with autism spectrum disorders: A randomized clinical trial. Vitamin D 11-20 interleukin 6 Homo sapiens 76-89 31497913-6 2020 We also found that quercetin can strongly reduce the concentration of serum creatinine, BUN, IL-1beta, IL-6, and TNF-alpha in cisplatin-induced AKI model. Cisplatin 126-135 interleukin 6 Homo sapiens 103-107 31982836-7 2020 The IL-6 production was reduced from conditioned media in both calcium depletion and low calcium groups. Calcium 63-70 interleukin 6 Homo sapiens 4-8 31982836-7 2020 The IL-6 production was reduced from conditioned media in both calcium depletion and low calcium groups. Calcium 89-96 interleukin 6 Homo sapiens 4-8 31412983-10 2020 RESULTS: Compared with AMSCs from severe asthma patients, dexamethasone inhibited cytokines (CCL5, CCL11 and IL-6) and promoted the phosphorylation of GR more significantly in normal AMSCs. Dexamethasone 58-71 interleukin 6 Homo sapiens 109-113 31102177-7 2020 Glu and Asp supplementation also modulated the expression of TGF-beta1, IL-10, TNF-alpha, IL-6 and IL-1beta in the testis and epididymis. Glutamic Acid 0-3 interleukin 6 Homo sapiens 90-94 31892218-5 2019 The hDPSCs exposed to HEMA let to an increment of ROS formation and in the expression of high levels of inflammatory mediators such as nuclear factor-kappaB (NFkB), inflammatory cytokines such as interleukin IL6, IL8, interferon (IFN)gamma and monocyte chemoattractant protein (MCP)1. poly(2-hydroxyethylmethacrylate)-TiO2 22-26 interleukin 6 Homo sapiens 208-211 32844633-1 2020 THE AIM OF THE STUDY: Was to evaluate the effect of selective serotonin reuptake inhibitor fluoxetine on the production of cytokines interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) by dendritic cells in multiple sclerosis (MS). Serotonin 62-71 interleukin 6 Homo sapiens 133-146 32844633-1 2020 THE AIM OF THE STUDY: Was to evaluate the effect of selective serotonin reuptake inhibitor fluoxetine on the production of cytokines interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) by dendritic cells in multiple sclerosis (MS). Serotonin 62-71 interleukin 6 Homo sapiens 148-152 31861674-5 2019 PEP correlated with cytosolic calcium and NFAT activity, together with transcriptional up-regulation of canonical targets PTGS2 and IL6 that was fully prevented by CsA pre-treatment. Cyclosporine 164-167 interleukin 6 Homo sapiens 132-135 31856268-1 2019 Atovaquone, a US Food and Drug Administration-approved antiparasitic drug previously shown to reduce interleukin-6/STAT3 signaling in myeloma cells, is well tolerated, and plasma concentrations of 40 to 80 microM have been achieved with pediatric and adult dosing. Atovaquone 0-10 interleukin 6 Homo sapiens 101-114 31824163-0 2019 The Effect of Coenzyme Q10 Supplementation on Vascular Endothelial Growth Factor and Serum Levels of Interleukin 6 and 8 in Women with Breast Cancer: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial. coenzyme Q10 14-26 interleukin 6 Homo sapiens 101-120 31874499-7 2019 Results: The differences between ISR group (n=52) and N-ISR group (n=355) were statistically significant in terms of diabetes history, IL-6, TNF-alpha, EATV ((150+-36) cm(3)vs(120+-40) cm(3),P=0.001)), bifurcation lesions, stent length and Gensini score (P<0.05). Nitrogen 54-55 interleukin 6 Homo sapiens 135-139 31539553-5 2019 We found that agonism of GPR39 using its specific agonist TC-G 1008 significantly ameliorated important markers of RA, including oxidative stress, mitochondrial dysfunction, expression of proinflammatory cytokines including interleukin-1beta (IL-1beta), IL-6, and monocyte chemoattractant protein 1 (MCP-1), and secretion of key matrix metalloproteinases (MMPs) including MMP-1, MMP-3 and MMP-13. GPR39-C3 58-67 interleukin 6 Homo sapiens 254-258 31885501-6 2019 Furthermore, fetal membrane and villous explants treated with LPS had higher tissue levels of sEH mRNA and protein and 14,15-DHET than those present in the vehicle controls, while the administration of AUDA in the media attenuated the LPS-induced production of 14,15-DHET in tissue homogenates and IL-1beta and IL-6 in the media of explant cultures. 12-(3-adamantan-1-ylureido)dodecanoic acid 202-206 interleukin 6 Homo sapiens 311-315 31797089-9 2019 Paclitaxel significantly up-regulated the expression of interleukin-6. Paclitaxel 0-10 interleukin 6 Homo sapiens 56-69 31824163-9 2019 Supplementation with CoQ10 demonstrated a significant decrease in IL-8 and IL-6 serum levels compared to placebo (P< 0.05). coenzyme Q10 21-26 interleukin 6 Homo sapiens 75-79 31631701-9 2019 The levels of inflammatory factors (TNF-alpha, IL-1beta, IL-6 and IL-10) were significantly regulated by silibinin treatment. Silybin 105-114 interleukin 6 Homo sapiens 57-61 31718404-4 2019 Compared with normotension (NT) group, CPA group has significantly higher protein levels of TNFalpha, IL-6, fibronectin (FN) and collagen I (COLI). cpa 39-42 interleukin 6 Homo sapiens 102-106 30880468-5 2019 The combination of DOX and KIR may promote therapeutic efficacy, at which the anti-apoptotic effect of the tumour cells was inhibited (by downregulating Bcl-2 and upregulating Bax) and the tumour progression-related inflammatory factors, such as tumour necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) were downregulated. Doxorubicin 19-22 interleukin 6 Homo sapiens 291-304 30880468-5 2019 The combination of DOX and KIR may promote therapeutic efficacy, at which the anti-apoptotic effect of the tumour cells was inhibited (by downregulating Bcl-2 and upregulating Bax) and the tumour progression-related inflammatory factors, such as tumour necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) were downregulated. Doxorubicin 19-22 interleukin 6 Homo sapiens 306-310 31702814-11 2019 ELISA indicated that miR-217 inhibitor significantly reduced the expression of inflammatory factors, such as interleukin (IL)-1beta, tumor necrosis factor-alpha, and IL-6 in high glucose-treated ARPE-19 cells. Glucose 179-186 interleukin 6 Homo sapiens 166-170 31699704-9 2019 Vitamin D resulted in 8.2% higher IL-6 (95% CI, 1.5%-15.3%; adjusted P = 0.02), but TNFR2 and hsCRP did not. Vitamin D 0-9 interleukin 6 Homo sapiens 34-38 31751886-10 2019 Besides, Curcumin and Capsaicin down-regulated expression of pro-inflammatory cytokines TNF-alpha, IL-6, and CXCL8/IL-8 and up regulated the expression of IL-10, a sign of lowered M1/M2 ratio relating to abrogation of inflammation. Curcumin 9-17 interleukin 6 Homo sapiens 99-103 31751886-10 2019 Besides, Curcumin and Capsaicin down-regulated expression of pro-inflammatory cytokines TNF-alpha, IL-6, and CXCL8/IL-8 and up regulated the expression of IL-10, a sign of lowered M1/M2 ratio relating to abrogation of inflammation. Capsaicin 22-31 interleukin 6 Homo sapiens 99-103 31246713-6 2019 Specifically, IL-1beta significantly increased from pre- to 5 min after both trials (23%, p<0.05), IL-6 increased 1h following both trials (39%, p<0.05), IL-10 was elevated 5 min after running (20%, p<0.05) and 1h after both running and cycling (41% and 64%, respectively, p<0.05), and TNF-alpha increased 5 min after running (10%, p<0.05). Hydrogen 117-119 interleukin 6 Homo sapiens 102-106 31433352-8 2019 Statistically significant increases in IL-6 concentrations were induced by morphine only; NK cell activity was suppressed with morphine, but maintained with oxycodone and epidural analgesia.Gene expression profiles suggest that at 2 h post-incision morphine appeared to be immunosuppressive as compared to oxycodone and non-opioid control analgesia. Morphine 75-83 interleukin 6 Homo sapiens 39-43 31536815-8 2019 Immunohistochemical analysis further suggested the inhibitory effects of Mg2+ on the expression of MMP-13 and IL-6 in the human tissue explants. magnesium ion 73-77 interleukin 6 Homo sapiens 110-114 31814911-0 2019 Sevoflurane induces apoptosis of isolated placental trophoblast cells and stimulates expressions of TNF-alpha and IL-6. sevoflurane 0-11 interleukin 6 Homo sapiens 114-118 31772161-0 2019 Erlotinib overcomes paclitaxel-resistant cancer stem cells by blocking the EGFR-CREB/GRbeta-IL-6 axis in MUC1-positive cervical cancer. erlotinib 0-9 interleukin 6 Homo sapiens 92-96 31772161-4 2019 Erlotinib, an EGFR-TKI, effectively impedes CSCs enrichment in paclitaxel-resistant cells through inhibiting IL-6. erlotinib 0-9 interleukin 6 Homo sapiens 109-113 31772161-5 2019 In this context, MUC1 induces CSCs enrichment in paclitaxel-resistant cells via activation of EGFR, which directly enhances IL-6 transcription through cAMP response element-binding protein (CREB) and glucocorticoid receptor beta (GRbeta). Paclitaxel 49-59 interleukin 6 Homo sapiens 124-128 31766398-0 2019 Redox Control of IL-6-Mediated Dental Pulp Stem-Cell Differentiation on Alginate/Hydroxyapatite Biocomposites for Bone Ingrowth. Hydroxyapatites 81-95 interleukin 6 Homo sapiens 17-21 31885477-6 2019 DB103 inhibited the induced-release of angiogenic factors such as monocyte chemotactic protein-1, interleukin-6 (IL-6) and angiopoietin-2 but not IL-8, while apigenin reduced the IL-6 and IL-8 release. Apigenin 158-166 interleukin 6 Homo sapiens 179-183 31631580-8 2019 Moreover, nevirapine significantly decreased the expression of IL-6 mRNA and phosphorylation of JAK2 (Y1007+Y1008) and STAT3 (Tyr 705) in WRO 82-1 cells compared with those in control cells. tyrosyltyrosine 126-129 interleukin 6 Homo sapiens 63-67 31772161-9 2019 Collectively, our work has demonstrated that the MUC1-EGFR-CREB/GRbeta axis stimulates IL-6 expression to induce CSCs enrichment and importantly, this effect can be abrogated by erlotinib, uncovering a novel strategy to treat paclitaxel-resistant cervical cancer. erlotinib 178-187 interleukin 6 Homo sapiens 87-91 31772161-9 2019 Collectively, our work has demonstrated that the MUC1-EGFR-CREB/GRbeta axis stimulates IL-6 expression to induce CSCs enrichment and importantly, this effect can be abrogated by erlotinib, uncovering a novel strategy to treat paclitaxel-resistant cervical cancer. Paclitaxel 226-236 interleukin 6 Homo sapiens 87-91 31885770-11 2019 Nonetheless, treatment of AAA-ASCs with rapamycin (an autophagy activator) dramatically reduced secretion of IL-6 and TNF-alpha and enhanced secretion of IL-10. Sirolimus 40-49 interleukin 6 Homo sapiens 109-113 31573734-0 2019 SIRT4 enhances the sensitivity of ER-positive breast cancer to tamoxifen by inhibiting the IL-6/STAT3 signal pathway. Tamoxifen 63-72 interleukin 6 Homo sapiens 91-95 31585112-11 2019 However, the increased secretion of inflammatory cytokines (IL-6 and IL-8) is sustained and these mediators may be involved in the pathophysiology of bladder toxicity following intravesical epirubicin treatment. Epirubicin 190-200 interleukin 6 Homo sapiens 60-64 31788012-0 2019 Plasma concentration of interleukin-6 was upregulated in cancer cachexia patients and was positively correlated with plasma free fatty acid in female patients. Fatty Acids 129-139 interleukin 6 Homo sapiens 24-37 31788012-11 2019 In comparison with female non-cachexic patients, female cachexic patients" IL-6 levels and FFA were significantly elevated with noticeable decrease in their BMI, total cholesterol, ApoE and prealbumin, as well as later TNM stage (all p < 0.05). Cholesterol 168-179 interleukin 6 Homo sapiens 75-79 31699008-2 2021 Recently, scientists studied L-arginine effect on inflammatory mediators such as C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). Arginine 29-39 interleukin 6 Homo sapiens 151-164 31699008-2 2021 Recently, scientists studied L-arginine effect on inflammatory mediators such as C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). Arginine 29-39 interleukin 6 Homo sapiens 166-170 31699008-10 2021 L-arginine could not reduce inflammatory mediators among patients with and without cancer except one article which indicated that taking L-arginine for 6 months decreased IL-6 among cardiopathic nondiabetic patients. Arginine 137-147 interleukin 6 Homo sapiens 171-175 31714459-8 2022 A significant correlation was observed between pre-post variations of IL-6 and GSH/GSSG ratio in plasma (p < 0.0001), which reinforces the integration between oxidative stress and inflammation during MMA combats. Glutathione 79-82 interleukin 6 Homo sapiens 70-74 31708994-7 2019 Initial exposure to H2O2 or TNFalpha enhanced SF senescence and increased mRNA expression of IL6, CXCL8, CCL2 and MMP3 and proteins secretion. Water 20-24 interleukin 6 Homo sapiens 93-96 31781264-7 2019 Berberine remarkably inhibited the proliferation and the excessive production of IL-6 and TNF-alpha in FLS-RA, whereas suppressing the expression of K-ras, c-Raf, and p-38/ERK-phosphorylation. Berberine 0-9 interleukin 6 Homo sapiens 81-85 31553636-11 2019 Gonadectomy also reduced ozone-induced expression of lung IL-6 and macrophage inflammatory protein-3 in females, which was restored by treatment with 17beta-estradiol. Ozone 25-30 interleukin 6 Homo sapiens 58-62 31553636-11 2019 Gonadectomy also reduced ozone-induced expression of lung IL-6 and macrophage inflammatory protein-3 in females, which was restored by treatment with 17beta-estradiol. Estradiol 150-166 interleukin 6 Homo sapiens 58-62 31257011-5 2019 RESULTS: Oral-tracheal administration of montelukast significantly attenuated total cells (P<.05), macrophages (P<.05), neutrophils (P<.01), lymphocytes (P<.001) and total protein levels in BAL (P<.05), as well as IL-6 (P<.05), CXCL1/KC (P<.05), IL-17 (P<.05) and TNF-alpha (P<.05). montelukast 41-52 interleukin 6 Homo sapiens 214-218 31719592-10 2019 These levels remained suppressed to 48 h of age with some recovery by 96 h. Reductions in serum iron were associated with high hepcidin and IL-6 levels. Iron 96-100 interleukin 6 Homo sapiens 140-144 31686264-7 2019 Immune markers such as IL-6, TNF-alpha, and TGF-beta show higher levels in ATPDs as compared to healthy controls. atpds 75-80 interleukin 6 Homo sapiens 23-27 31475727-5 2019 The nadir in serum testosterone preceded the post-prandial increase in serum IL-6/IL-17 by several hours, suggesting that inflammation was unlikely the cause. Testosterone 19-31 interleukin 6 Homo sapiens 77-81 31659097-10 2019 Similar trends were seen for apigenin-mediated down-regulation of TNFalpha-up-regulated transcripts: IKBKE (TNFalpha: 4.55 FC vs. control, p<0.001; and TNFalpha plus apigenin: -4.92 FC, p<0.001), CCL2 (2.19 FC, p<0.002; and -2.12 FC, p<0.003), IL6 (3.25 FC, p<0.020; and -2.85 FC, p<0.043) and CSF2 (TNFalpha +6.04 FC, p<0.001; and -2.36 FC, p<0.007). Apigenin 29-37 interleukin 6 Homo sapiens 256-259 31672939-6 2019 Macrophages demonstrate signs of an increased proinflammatory phenotype after salt exposure, as represented by boosted LPS-induced cytokine secretion of IL-6, TNF, and IL-10 in vitro, and by increased HLA-DR expression and decreased CD206 expression on skin macrophages after high-salt diet. Salts 78-82 interleukin 6 Homo sapiens 153-157 31454535-7 2019 Moreover, carbamate 10 exhibited moderate antiinflammatory activity by decreasing the expression of cytokines, TNF-alpha and IL-6 in LPS-induced inflammation in primary macrophage cells. Carbamates 10-19 interleukin 6 Homo sapiens 125-129 31228727-10 2019 Combining 6 effect sizes from 5 studies, we found a significant reduction in serum IL-6 concentrations after Atorvastatin therapy (WMD: -2.13; 95% CI: -3.96, -0.30; I2 = 98.6%). Atorvastatin 109-121 interleukin 6 Homo sapiens 83-87 31228727-12 2019 In addition, Atorvastatin administration resulted in reduced serum IL-6 concentrations in these people. Atorvastatin 13-25 interleukin 6 Homo sapiens 67-71 31513981-0 2019 Correlation between interleukin-6 levels and methadone maintenance therapy outcomes. Methadone 45-54 interleukin 6 Homo sapiens 20-33 31513981-9 2019 Plasma IL-6 levels were significantly associated with plasma morphine levels (P = 0.005) and urinary morphine-positive (+) results (P = 0.04), and significantly associated with poor compliance (P = 0.009) and early dropout from MMT (P = 0.001). Morphine 61-69 interleukin 6 Homo sapiens 7-11 31513981-9 2019 Plasma IL-6 levels were significantly associated with plasma morphine levels (P = 0.005) and urinary morphine-positive (+) results (P = 0.04), and significantly associated with poor compliance (P = 0.009) and early dropout from MMT (P = 0.001). Morphine 101-109 interleukin 6 Homo sapiens 7-11 31663569-8 2019 IL-6 was decreased in both groups but significantly in the CY group (1.33 +- 0.13 vs. 1.67 +- 0.63 pg mL-1, P < 0.05). Cysteine 59-61 interleukin 6 Homo sapiens 0-4 31683341-0 2019 Treatment with Metformin and Combination of Metformin Plus Pioglitazone on Serum Levels of IL-6 and IL-8 in Polycystic Ovary Syndrome: A Randomized Clinical Trial. Metformin 44-53 interleukin 6 Homo sapiens 91-95 31683341-14 2019 Combination of metformin and pioglitazone therapy was more effective as compared to metformin alone in reducing the levels of IL-6 and IL-8 as well as insulin resistance in PCOS. Metformin 15-24 interleukin 6 Homo sapiens 126-130 31683341-14 2019 Combination of metformin and pioglitazone therapy was more effective as compared to metformin alone in reducing the levels of IL-6 and IL-8 as well as insulin resistance in PCOS. Metformin 84-93 interleukin 6 Homo sapiens 126-130 31545398-8 2019 The present study also demonstrated that bexarotene exerted an anti-inflammatory effect by downregulating expression of interleukin (IL)-6, IL-8, monocyte chemoattractant protein-1, and high mobility group box-1. Bexarotene 41-51 interleukin 6 Homo sapiens 120-138 31795608-7 2019 PDRN treatment reduced TNF-alpha, IL-1beta, and IL-6 expression in POCD conditions, and significantly increased cAMP concentrations and the p-CREB/CREB ratio. Polydeoxyribonucleotides 0-4 interleukin 6 Homo sapiens 48-52 31507089-0 2019 Reciprocal regulation of miR-206 and IL-6/STAT3 pathway mediates IL6-induced gefitinib resistance in EGFR-mutant lung cancer cells. Gefitinib 77-86 interleukin 6 Homo sapiens 37-41 31507089-0 2019 Reciprocal regulation of miR-206 and IL-6/STAT3 pathway mediates IL6-induced gefitinib resistance in EGFR-mutant lung cancer cells. Gefitinib 77-86 interleukin 6 Homo sapiens 65-68 31507089-3 2019 However, whether miR-206 may overcome IL6-induced gefitinib resistance in EGFR-mutant lung cancer remains elusive. Gefitinib 50-59 interleukin 6 Homo sapiens 38-41 31507089-4 2019 In this study, we investigated the role of miR-206 in IL6-induced gefitinib-resistant EGFR-mutated lung cancer cell lines. Gefitinib 66-75 interleukin 6 Homo sapiens 54-57 31507089-5 2019 We showed that forced miR-206 expression restored gefitinib sensitivity in IL6-induced gefitinib-resistant EGFR-mutant lung cancer cells by inhibiting IL6/JAK1/STAT3 pathway. Gefitinib 50-59 interleukin 6 Homo sapiens 75-78 31507089-5 2019 We showed that forced miR-206 expression restored gefitinib sensitivity in IL6-induced gefitinib-resistant EGFR-mutant lung cancer cells by inhibiting IL6/JAK1/STAT3 pathway. Gefitinib 50-59 interleukin 6 Homo sapiens 151-154 31507089-5 2019 We showed that forced miR-206 expression restored gefitinib sensitivity in IL6-induced gefitinib-resistant EGFR-mutant lung cancer cells by inhibiting IL6/JAK1/STAT3 pathway. Gefitinib 87-96 interleukin 6 Homo sapiens 75-78 31507089-5 2019 We showed that forced miR-206 expression restored gefitinib sensitivity in IL6-induced gefitinib-resistant EGFR-mutant lung cancer cells by inhibiting IL6/JAK1/STAT3 pathway. Gefitinib 87-96 interleukin 6 Homo sapiens 151-154 31507089-8 2019 Taken together, our findings reveal a direct role of miR-206 in regulating IL-6/STAT3 pathway and contrarily activated IL-6/STAT3 signalling mediates the miR-206 maturation process in gefitinib-resistant EGFR-mutant lung cancer cells. Gefitinib 184-193 interleukin 6 Homo sapiens 119-123 31546233-3 2019 24 and/or 48 hours exposure to BPA 0.1 nM elicited significant increase of the inflammatory molecules interleukin-6 (IL-6), interleukin-8 (IL-8), Monocyte chemo-attractant protein 1alpha (MCP1alpha) and induced G protein-coupled estrogen receptor 30 (GPR30) levels more than 2-fold both in mature adipocytes and SVF cells. bisphenol A 31-34 interleukin 6 Homo sapiens 102-115 31546233-3 2019 24 and/or 48 hours exposure to BPA 0.1 nM elicited significant increase of the inflammatory molecules interleukin-6 (IL-6), interleukin-8 (IL-8), Monocyte chemo-attractant protein 1alpha (MCP1alpha) and induced G protein-coupled estrogen receptor 30 (GPR30) levels more than 2-fold both in mature adipocytes and SVF cells. bisphenol A 31-34 interleukin 6 Homo sapiens 117-121 30988378-0 2019 Metformin inhibits IL-6 signaling by decreasing IL-6R expression on multiple myeloma cells. Metformin 0-9 interleukin 6 Homo sapiens 19-23 31570278-6 2019 Additionally, evidence was provided that TET2 regulated interleukin-6 levels in the tumor microenvironment through histone acetylation and therefore served an important role in the development of cisplatin resistance in GC cells. Cisplatin 196-205 interleukin 6 Homo sapiens 56-69 31545444-6 2019 Consistently, senescent astrocytic CRT cells induced by D-galactose exhibited increases in the levels of IL-6 and IL-8 via NF-kappaB activation, which are major SASP components and inflammatory cytokines. Galactose 56-67 interleukin 6 Homo sapiens 105-109 31773054-5 2019 In children with s-creatinine increase, IL-6 values were significantly different between AR and cAMR. Creatinine 19-29 interleukin 6 Homo sapiens 40-44 31880211-6 2019 Serum IL-1beta, IL-6, and TNF-alpha concentrations significantly decreased for hydrocortisone group at day 7 (all p < .01). Hydrocortisone 79-93 interleukin 6 Homo sapiens 16-20 31780862-6 2019 Serum IL-35 levels were significantly increased and serum levels of TNF-alpha, IL-17, IL-6, and IFN-gamma were significantly reduced in response to tofacitinib since week 4. tofacitinib 148-159 interleukin 6 Homo sapiens 86-90 31695471-11 2019 Results: Linagliptin significantly prevented LPS-stimulated IL-6 production and intranuclear NF-kappaB/p65 levels in a concentration-dependent manner. linagliptin 9-20 interleukin 6 Homo sapiens 60-64 31615122-1 2019 The novel exchange protein activated by cyclic AMP (EPAC1) activator, I942, induces expression of the suppressor of cytokine signalling 3 (SOCS3) gene, thereby inhibiting interleukin 6 (IL6) inflammatory processes in human umbilical vein endothelial cells (HUVECs). Cyclic AMP 40-50 interleukin 6 Homo sapiens 171-184 31615122-1 2019 The novel exchange protein activated by cyclic AMP (EPAC1) activator, I942, induces expression of the suppressor of cytokine signalling 3 (SOCS3) gene, thereby inhibiting interleukin 6 (IL6) inflammatory processes in human umbilical vein endothelial cells (HUVECs). Cyclic AMP 40-50 interleukin 6 Homo sapiens 186-189 31665127-4 2019 MATERIAL AND METHODS Expression of miR-34b, IL-6R, and other key factors of inflammation, apoptosis (TNF-alpha, IL-1ss, IL-6, caspase-3) in high glucose (HG)-induced HK-2 cells were measured by real-time PCR, Western blot, and flow cytometric cell apoptosis assays. Glucose 145-152 interleukin 6 Homo sapiens 44-48 31476115-7 2019 Our results show that APZ and the known DHCR7 inhibitor, AY9944, increase 7-DHC levels in airway epithelial cells and potentiate O3-induced IL-6 and IL-8 expression and cytokine release. Ozone 129-131 interleukin 6 Homo sapiens 140-144 31476115-9 2019 Additionally, we find that APZ increases O3-induced IL-6 and IL-8 expression in human nasal epithelial cells from male but not female donors. Ozone 41-43 interleukin 6 Homo sapiens 52-56 31489456-5 2019 In addition, cordycepene increases the antioxidant activity (SOD, superoxide dismutase; GSH-Px, glutathione peroxidase; CAT, catalase) and decreases MDA (malondialdehyde) level, indicating that cordycepene inhibits the photochemical senescence of HSF by enhancing the antioxidant defense system. cordycepene 13-24 interleukin 6 Homo sapiens 247-250 31299118-9 2019 In patients with PE, 25(OH)D level correlated negatively with IL-6 levels (r = -.60, P < .0001) and positively with Treg/Th17 cell ratio (r = .89, P < .0001). 25(oh)d 21-28 interleukin 6 Homo sapiens 62-66 31346700-4 2019 By acting on IL-6 expression, metformin might have a positive impact on the main molecular pathways strictly connected with pathogenesis and biological features of ovarian cancer. Metformin 30-39 interleukin 6 Homo sapiens 13-17 31486959-4 2019 Further, The docking of curcumin and capsaicin at the active pockets of COX-2, IL-6 and TGF-beta has shown - 3.90, - 4.49 and - 5.61 kcal/mol binding energy for curcumin and - 3.80, - 4.78 and - 5.76 kcal/mol binding energy for capsaicin, while multiple ligand simultaneous docking (MLSD) of both molecules has shown higher binding energy of - 4.24, - 5.35 and - 5.83 kcal/mol respectively. Capsaicin 228-237 interleukin 6 Homo sapiens 79-83 30989422-10 2019 We demonstrate an association between the rs1800796 genetic variant of the IL-6 gene with components of MetS including BMI, and HDL-cholesterol, but not the MetS itself. Cholesterol 132-143 interleukin 6 Homo sapiens 75-79 31444999-14 2019 Ponatinib treatment significantly increased plasma VEGF, soluble (s)VEGFR1, sVEGFR2, sTIE2, interferon gamma (IFNgamma), tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-6, IL-8, and IL-10 and decreased sVEGFR2. ponatinib 0-9 interleukin 6 Homo sapiens 162-180 31486959-0 2019 Curcumin and capsaicin modulates LPS induced expression of COX-2, IL-6 and TGF-beta in human peripheral blood mononuclear cells. Curcumin 0-8 interleukin 6 Homo sapiens 66-70 31486959-0 2019 Curcumin and capsaicin modulates LPS induced expression of COX-2, IL-6 and TGF-beta in human peripheral blood mononuclear cells. Capsaicin 13-22 interleukin 6 Homo sapiens 66-70 31489456-4 2019 Cordycepene promotes the growth of HSF (human skin fibroblast cell) after incubation for 72 h, and has an ability to repair the UV light-treated HSF cells. cordycepene 0-11 interleukin 6 Homo sapiens 35-38 31489456-4 2019 Cordycepene promotes the growth of HSF (human skin fibroblast cell) after incubation for 72 h, and has an ability to repair the UV light-treated HSF cells. cordycepene 0-11 interleukin 6 Homo sapiens 145-148 31220426-13 2019 In addition, in co-cultures independent of Mo origin, ASA reduced IL-6, IL-8, MCP-1, and TNF-alpha. Aspirin 54-57 interleukin 6 Homo sapiens 66-70 31486959-2 2019 RT-PCR analysis has shown that the curcumin and capsaicin significantly reduced LPS induced over expression of COX-2, IL-6 and TGF-beta in PBMCs. Curcumin 35-43 interleukin 6 Homo sapiens 118-122 31276896-4 2019 Furthermore, the amine 4c, naphthoquinone 5, and azo-based 13 and 15 organic selenides were able to down-regulate the expression of Bcl-2 and up-regulate the expression levels of IL-2, IL-6 and CD40 in HepG2 cells compared to untreated cells. azo-based 49-58 interleukin 6 Homo sapiens 185-189 31486959-2 2019 RT-PCR analysis has shown that the curcumin and capsaicin significantly reduced LPS induced over expression of COX-2, IL-6 and TGF-beta in PBMCs. Capsaicin 48-57 interleukin 6 Homo sapiens 118-122 31486959-4 2019 Further, The docking of curcumin and capsaicin at the active pockets of COX-2, IL-6 and TGF-beta has shown - 3.90, - 4.49 and - 5.61 kcal/mol binding energy for curcumin and - 3.80, - 4.78 and - 5.76 kcal/mol binding energy for capsaicin, while multiple ligand simultaneous docking (MLSD) of both molecules has shown higher binding energy of - 4.24, - 5.35 and - 5.83 kcal/mol respectively. Curcumin 24-32 interleukin 6 Homo sapiens 79-83 31486959-4 2019 Further, The docking of curcumin and capsaicin at the active pockets of COX-2, IL-6 and TGF-beta has shown - 3.90, - 4.49 and - 5.61 kcal/mol binding energy for curcumin and - 3.80, - 4.78 and - 5.76 kcal/mol binding energy for capsaicin, while multiple ligand simultaneous docking (MLSD) of both molecules has shown higher binding energy of - 4.24, - 5.35 and - 5.83 kcal/mol respectively. Capsaicin 37-46 interleukin 6 Homo sapiens 79-83 31486959-4 2019 Further, The docking of curcumin and capsaicin at the active pockets of COX-2, IL-6 and TGF-beta has shown - 3.90, - 4.49 and - 5.61 kcal/mol binding energy for curcumin and - 3.80, - 4.78 and - 5.76 kcal/mol binding energy for capsaicin, while multiple ligand simultaneous docking (MLSD) of both molecules has shown higher binding energy of - 4.24, - 5.35 and - 5.83 kcal/mol respectively. Curcumin 161-169 interleukin 6 Homo sapiens 79-83 31254476-7 2019 A higher (40 mM) concentration of NaCl in the culture medium resulted in increased secretion of prostaglandin, expression of alkaline phosphatase, and expression of genes involved in extracellular matrix remodeling, but decreased compression-induced expression of the interleukin-6 (IL6) gene. Sodium Chloride 34-38 interleukin 6 Homo sapiens 268-281 31254476-7 2019 A higher (40 mM) concentration of NaCl in the culture medium resulted in increased secretion of prostaglandin, expression of alkaline phosphatase, and expression of genes involved in extracellular matrix remodeling, but decreased compression-induced expression of the interleukin-6 (IL6) gene. Sodium Chloride 34-38 interleukin 6 Homo sapiens 283-286 31338585-7 2019 Both dexamethasone and tocilizumab influenced IL-6 and IL-6Rs levels in patients" group. Dexamethasone 5-18 interleukin 6 Homo sapiens 46-50 31266368-6 2019 Here, we show that both function-selective and ATP-competitive ERK1/2 inhibitors are effective at inhibiting PDGF-mediated proliferation, collagen production, and IL-6 secretion in ASM cells. Adenosine Triphosphate 47-50 interleukin 6 Homo sapiens 163-167 31517562-7 2019 Fluticasone propionate (FP) and dexamethasone (DEX) suppressed IL-6 and IL-8 production in BEAS-2B cells, but clarithromycin (CAM) failed to do so. Dexamethasone 32-45 interleukin 6 Homo sapiens 63-67 31517562-7 2019 Fluticasone propionate (FP) and dexamethasone (DEX) suppressed IL-6 and IL-8 production in BEAS-2B cells, but clarithromycin (CAM) failed to do so. Dexamethasone 47-50 interleukin 6 Homo sapiens 63-67 31338585-13 2019 These results strengthen the molecular rationale for interrogating the efficacy of tocilizumab in steroid-resistant TED, as IL-6 seems to be a common target for both anti-IL-6R antibody and steroids. Steroids 98-105 interleukin 6 Homo sapiens 124-128 31338585-8 2019 Supernatants obtained from PBMCs treated with dexamethasone showed 77.2% and 82.8% lower IL-6 levels compared with those cultured with placebo and tocilizumab, respectively. Dexamethasone 46-59 interleukin 6 Homo sapiens 89-93 31338585-13 2019 These results strengthen the molecular rationale for interrogating the efficacy of tocilizumab in steroid-resistant TED, as IL-6 seems to be a common target for both anti-IL-6R antibody and steroids. Steroids 190-198 interleukin 6 Homo sapiens 124-128 31338585-11 2019 CONCLUSIONS: Both dexamethasone and tocilizumab affect the IL-6/sIL-6R system. Dexamethasone 18-31 interleukin 6 Homo sapiens 59-63 31165327-10 2019 In conclusion, combination of resveratrol and silymarin could significantly inhibit inflammatory effects of histamine on cultured HGFs by reduction of IL-6, IL-8, TPA-1, and TNF-alpha. Resveratrol 30-41 interleukin 6 Homo sapiens 151-155 31165327-10 2019 In conclusion, combination of resveratrol and silymarin could significantly inhibit inflammatory effects of histamine on cultured HGFs by reduction of IL-6, IL-8, TPA-1, and TNF-alpha. Histamine 108-117 interleukin 6 Homo sapiens 151-155 31511352-3 2019 Here, we demonstrated that E2 widely activated adipose inflammatory factors such as fatty acid desaturase 1 (FADS1), IL6, and TNFalpha in LTED breast cancer cells. Estradiol 27-29 interleukin 6 Homo sapiens 117-120 31325727-9 2019 RESULTS: Myricetin not only inhibited the generation of inflammatory mediators and cytokines such as nitric oxide (NO), prostaglandin E2 (PGE2), TNF-alpha and IL-6, but also suppressed the production of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in human chondrocytes under IL-1beta stimulation. myricetin 9-18 interleukin 6 Homo sapiens 159-163 31349449-6 2019 Zn-doped cryogels supported migration of human skin fibroblasts (HSF); only upper Zn content of 11.8 x 103 ppm in the scaffold caused c.a. Zinc 0-2 interleukin 6 Homo sapiens 65-68 31349449-8 2019 Zn ions solubilized in culture medium were more active towards HSF (IC50 0.3 mM). Zinc 0-2 interleukin 6 Homo sapiens 63-66 31332969-5 2019 T. forsythia-stimulated reactive oxygen species (ROS) induced the expression of IL-24, which was regulated by IL-6. Reactive Oxygen Species 24-47 interleukin 6 Homo sapiens 110-114 31332969-5 2019 T. forsythia-stimulated reactive oxygen species (ROS) induced the expression of IL-24, which was regulated by IL-6. Reactive Oxygen Species 49-52 interleukin 6 Homo sapiens 110-114 31332969-6 2019 The ROS inhibitor N-acetylcysteine and MAPK inhibitors significantly reduced the expression of IL-6 and IL-24 induced by T. forsythia. Acetylcysteine 18-34 interleukin 6 Homo sapiens 95-99 31313075-8 2019 On the other hand, montelukast suppressed the expression and production of matrix metalloproteinases (MMPs) and cytokines including MMP-2, MMP-9, interleukin 1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interleukin 6 (IL-6). montelukast 19-30 interleukin 6 Homo sapiens 221-234 31313075-8 2019 On the other hand, montelukast suppressed the expression and production of matrix metalloproteinases (MMPs) and cytokines including MMP-2, MMP-9, interleukin 1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interleukin 6 (IL-6). montelukast 19-30 interleukin 6 Homo sapiens 236-240 31593984-5 2019 Results: Treatment with curcumin resulted in a dose- and time-dependent decrease in IL-1beta-induced synthesis of inflammatory cytokines, including IL-6, IL-8, MCP-1, and ICAM-1 at both mRNA and protein levels. Curcumin 24-32 interleukin 6 Homo sapiens 148-152 31313838-1 2019 OBJECTIVES: This study aimed to investigate the clearance pathways of lamotrigine (LTG)-loaded micelles by intranasal administration and intracerebral injection in the brain and whether nanoparticles can induce the inflammation promoted by interleukin-6 (IL-6), accelerating the phagocytosis of drug particles in the brain and drainage through lymphatics. Lamotrigine 70-81 interleukin 6 Homo sapiens 240-253 31313838-1 2019 OBJECTIVES: This study aimed to investigate the clearance pathways of lamotrigine (LTG)-loaded micelles by intranasal administration and intracerebral injection in the brain and whether nanoparticles can induce the inflammation promoted by interleukin-6 (IL-6), accelerating the phagocytosis of drug particles in the brain and drainage through lymphatics. Lamotrigine 70-81 interleukin 6 Homo sapiens 255-259 31313838-1 2019 OBJECTIVES: This study aimed to investigate the clearance pathways of lamotrigine (LTG)-loaded micelles by intranasal administration and intracerebral injection in the brain and whether nanoparticles can induce the inflammation promoted by interleukin-6 (IL-6), accelerating the phagocytosis of drug particles in the brain and drainage through lymphatics. Lamotrigine 83-86 interleukin 6 Homo sapiens 240-253 31313838-1 2019 OBJECTIVES: This study aimed to investigate the clearance pathways of lamotrigine (LTG)-loaded micelles by intranasal administration and intracerebral injection in the brain and whether nanoparticles can induce the inflammation promoted by interleukin-6 (IL-6), accelerating the phagocytosis of drug particles in the brain and drainage through lymphatics. Lamotrigine 83-86 interleukin 6 Homo sapiens 255-259 31313838-4 2019 After intranasal administration of lamotrigine-loaded micelles for 30 min, the IL-6 concentrations in deep cervical lymph node and brain tissue were significantly increased (P < 0.05). Lamotrigine 35-46 interleukin 6 Homo sapiens 79-83 31443893-0 2019 Mindfulness practice predicts interleukin-6 responses to a mindfulness-based alcohol relapse prevention intervention. Alcohols 77-84 interleukin 6 Homo sapiens 30-43 31443893-1 2019 Chronic alcohol misuse can result in chronically elevated interleukin (IL)-6, a pro-inflammatory cytokine, in the bloodstream. Alcohols 8-15 interleukin 6 Homo sapiens 58-76 31364019-8 2019 High positive correlations were found between Cd levels of participants and IL-6, IL-10, TNF-alpha and CRP levels (r = 0.568, r = 0.615, r = 0.614 and r = 0.296, respectively, p < 0.01). Cadmium 46-48 interleukin 6 Homo sapiens 76-80 31364019-9 2019 In terms of the regression analysis results, there were significant effects of Cd on IL-6, IL-10 and TNF-alpha levels (p < 0.05). Cadmium 79-81 interleukin 6 Homo sapiens 85-89 31364019-11 2019 In conclusion, increasing levels of Se and Zn decreases the intensity of inflammation as measured by IL-6, IL-10 and TNF-alpha levels. Zinc 43-45 interleukin 6 Homo sapiens 101-105 31485664-7 2019 Pomalidomide, a TNF-alpha release inhibitor, reduced the expression of IL-6, TNF-alpha, TLR4, TLR5 and phosphorylated-p65, and upregulated that of IL-10, TLR3 and p65 in peripheral blood mononuclear cells from patients with AS. pomalidomide 0-12 interleukin 6 Homo sapiens 71-75 31511352-4 2019 Activation of glucocorticoid receptor (GR) by the synthetic glucocorticoid dexamethasone upregulated FADS1 and IL6, but downregulated TNFalpha expression. Dexamethasone 75-88 interleukin 6 Homo sapiens 111-114 31511352-5 2019 Furthermore, dexamethasone was synergistic or additive with E2 in upregulating FADS1 and IL6 expression, whereas it selectively and constantly suppressed TNFalpha expression induced by E2 in LTED breast cancer cells. Dexamethasone 13-26 interleukin 6 Homo sapiens 89-92 31511352-5 2019 Furthermore, dexamethasone was synergistic or additive with E2 in upregulating FADS1 and IL6 expression, whereas it selectively and constantly suppressed TNFalpha expression induced by E2 in LTED breast cancer cells. Estradiol 60-62 interleukin 6 Homo sapiens 89-92 31185284-0 2019 Can coenzyme Q10 supplementation effectively reduce human tumor necrosis factor-alpha and interleukin-6 levels in chronic inflammatory diseases? coenzyme Q10 4-16 interleukin 6 Homo sapiens 90-103 31466863-7 2019 IL-6 peritumoural expression was higher in GI-NETs of patients with low HDL cholesterol (0.018+-0.005% vs 0.030+-0.005%, p=0.02). Cholesterol 76-87 interleukin 6 Homo sapiens 0-4 31185284-5 2019 The objective of this systematic review and meta-analysis of randomized clinical trials (RCTs) was to assess the efficacy of CoQ10 supplementation on tumor necrosis factor- alpha (TNF-alpha) and interleukin-6 (IL-6) levels. coenzyme Q10 125-130 interleukin 6 Homo sapiens 195-208 31185284-5 2019 The objective of this systematic review and meta-analysis of randomized clinical trials (RCTs) was to assess the efficacy of CoQ10 supplementation on tumor necrosis factor- alpha (TNF-alpha) and interleukin-6 (IL-6) levels. coenzyme Q10 125-130 interleukin 6 Homo sapiens 210-214 31185284-12 2019 Our meta-analysis indicated that oral CoQ10 supplementation (60-500 mg/day for 8-12 weeks) resulted in significant reduction of TNF-alpha (SMD: -0.44, 95% CI: [-0.81 to -0.07] mg/dl; I2 = 66.1%, p = 0.00) and IL-6 levels (SMD: -0.37, 95% CI: [-0.65 to -0.09]; I2 = 57.2, p = 0.01), respectively. coenzyme Q10 38-43 interleukin 6 Homo sapiens 210-214 31442575-7 2019 Metformin and Liraglutide were shown to elicit significantly greater release of TNFa, IL-6, and GM-CSF, while Sitagliptin had a lesser effect on pro-inflammatory cytokine production. Metformin 0-9 interleukin 6 Homo sapiens 86-90 31554244-6 2019 Finally, we present preliminary data showing that the cytokine IL-6 cross talks with activation of the c-Jun N-terminal kinase pathway in response to heme-hemopexin in models of hepatocytes. Nitrogen 109-110 interleukin 6 Homo sapiens 63-67 31252067-0 2019 Cadmium exposure induces interleukin-6 production via ROS-dependent activation of the ERK1/2 but independent of JNK signaling pathway in human placental JEG-3 trophoblast cells. Cadmium 0-7 interleukin 6 Homo sapiens 25-38 31252067-0 2019 Cadmium exposure induces interleukin-6 production via ROS-dependent activation of the ERK1/2 but independent of JNK signaling pathway in human placental JEG-3 trophoblast cells. ros 54-57 interleukin 6 Homo sapiens 25-38 31252067-3 2019 Cd induces IL-6 production in various cell types through different signaling pathways. Cadmium 0-2 interleukin 6 Homo sapiens 11-15 31252067-4 2019 Thus, this study was designed to investigate the effect of Cd on IL-6 production and the underlying mechanisms in a trophoblast-derived cell line. Cadmium 59-61 interleukin 6 Homo sapiens 65-69 31252067-8 2019 Cd exposure induced IL-6 production and increased ERK1/2, JNK, and c-Jun phosphorylation. Cadmium 0-2 interleukin 6 Homo sapiens 20-24 31252067-9 2019 NAC and the inhibition of ERK1/2 significantly reduced Cd-induced IL-6 production. Cadmium 55-57 interleukin 6 Homo sapiens 66-70 31252067-10 2019 These data indicate that Cd induces IL-6 production in trophoblast cells through a ROS-dependent activation of ERK1/2. Cadmium 25-27 interleukin 6 Homo sapiens 36-40 31252067-10 2019 These data indicate that Cd induces IL-6 production in trophoblast cells through a ROS-dependent activation of ERK1/2. ros 83-86 interleukin 6 Homo sapiens 36-40 31339859-4 2019 Results Under basal conditions, IL-1beta and IL-6 production was enhanced by BPA in a dose-dependent manner. bisphenol A 77-80 interleukin 6 Homo sapiens 45-49 31339859-5 2019 Sgp130, a soluble receptor that reduces IL-6 bioactivity, was suppressed by BPA at 1000-10,000 nM. bisphenol A 76-79 interleukin 6 Homo sapiens 40-44 31339859-7 2019 For bacteria-treated cultures, BPA increased IL-6 production at 100 nM and reduced sgp130 at 1000 nM but had no effect on IL-1beta, TNF-alpha, BDNF, HO-1, 8-IsoP or IL-10 production. bisphenol A 31-34 interleukin 6 Homo sapiens 45-49 31339859-8 2019 Conclusion BPA may increase placental inflammation by promoting IL-1beta and IL-6 but inhibiting sgp130. bisphenol A 11-14 interleukin 6 Homo sapiens 77-81 31295461-0 2019 The correlation between low vitamin D status and renal interleukin-6/STAT3 hyper-activation in patients with clear cell renal cell carcinoma. Vitamin D 28-37 interleukin 6 Homo sapiens 55-68 31295461-2 2019 This study aimed to analyze the link between low vitamin D status and interleukin (IL)-6/STAT3 hyper-activation in clear cell RCC (ccRCC) patients. Vitamin D 49-58 interleukin 6 Homo sapiens 70-88 31295461-4 2019 The association between low vitamin D status and IL-6/STAT3 hyper-activation was analyzed. Vitamin D 28-37 interleukin 6 Homo sapiens 49-53 31295461-15 2019 Our results provide evidence that low vitamin D status is correlated with hyper-activation of cancerous IL-6/STAT3 and proliferation in ccRCC patients. Vitamin D 38-47 interleukin 6 Homo sapiens 104-108 31583075-4 2019 The results confirmed that H4R has the functional effects of mediating cytokine production (i.e., down-regulating IFN-gamma and up-regulating IL-6) in cells from a monocyte cell line following challenge with histamine. Histamine 208-217 interleukin 6 Homo sapiens 142-146 31547604-0 2019 Regulation of Heat Shock Factor Pathways by gamma-aminobutyric Acid (GABA) Associated with Thermotolerance of Creeping Bentgrass. gamma-Aminobutyric Acid 44-67 interleukin 6 Homo sapiens 14-31 31616316-7 2019 Enrichment analysis and comparison with a dataset of atrial tissue from AF patients revealed indications of increased carbohydrate metabolism and changes in pathways that are thought to play critical roles in human AF, including TGF-beta and IL-6 signaling. Carbohydrates 118-130 interleukin 6 Homo sapiens 242-246 31547604-0 2019 Regulation of Heat Shock Factor Pathways by gamma-aminobutyric Acid (GABA) Associated with Thermotolerance of Creeping Bentgrass. gamma-Aminobutyric Acid 69-73 interleukin 6 Homo sapiens 14-31 31547604-6 2019 Transcriptional analyses showed that exogenous GABA could significantly upregulate transcript levels of genes encoding heat shock factor HSFs (HSFA-6a, HSFA-2c, and HSFB-2b), heat shock proteins (HSP17.8, HSP26.7, HSP70, and HSP90.1-b1), and ascorbate peroxidase 3 (APX3), whereas the inhibition of GABA biosynthesis depressed these genes expression under heat stress. gamma-Aminobutyric Acid 47-51 interleukin 6 Homo sapiens 119-136 31547604-6 2019 Transcriptional analyses showed that exogenous GABA could significantly upregulate transcript levels of genes encoding heat shock factor HSFs (HSFA-6a, HSFA-2c, and HSFB-2b), heat shock proteins (HSP17.8, HSP26.7, HSP70, and HSP90.1-b1), and ascorbate peroxidase 3 (APX3), whereas the inhibition of GABA biosynthesis depressed these genes expression under heat stress. gamma-Aminobutyric Acid 299-303 interleukin 6 Homo sapiens 119-136 31547604-7 2019 Our results indicate GABA regulates thermotolerance associated with activation and enhancement of HSF pathways in creeping bentgrass. gamma-Aminobutyric Acid 21-25 interleukin 6 Homo sapiens 98-101 31645839-11 2019 All together these data suggest that the inhibition of mTORC1 in human microglia by rapamycin results in complex immunomodulatory effects, including a significant increase in the expression and release of the pro-inflammatory IL-6. Sirolimus 84-93 interleukin 6 Homo sapiens 226-230 31513610-6 2019 DOX also increased MMP1, IL-6, TGF-beta and collagen expression in human cardiac fibroblasts (HCFs). Doxorubicin 0-3 interleukin 6 Homo sapiens 25-29 31513610-8 2019 A Smad inhibitor prevented DOX-induced alpha-SMA and IL-6 protein expression. Doxorubicin 27-30 interleukin 6 Homo sapiens 53-57 31890669-12 2019 Furthermore, there was a significant positive correlation between IL-6 with MDA (p = 0.031, r = 0.482) and TOS (p < 0.001, r = 0.744). Malondialdehyde 76-79 interleukin 6 Homo sapiens 66-70 31541125-8 2019 Furthermore, the production of IL6 induced by H2O2 was suppressed by the THGP treatment. Water 46-50 interleukin 6 Homo sapiens 31-34 31572383-10 2019 O3 stimulated release of pro-neutrophilic mediators including CCL20 and IL-6 into the airways and impaired the inhibitory effects of budesonide on CCL11, IL-13 and IL-23. Ozone 0-2 interleukin 6 Homo sapiens 72-76 31572383-13 2019 Dexamethasone and budesonide induced sftpd transcription and translation in human type II alveolar epithelial cells in a glucocorticoid receptor and STAT3 (an IL-6 responsive transcription factor) dependent manner. Dexamethasone 0-13 interleukin 6 Homo sapiens 159-163 31572184-0 2019 Apigenin Inhibits IL-6 Transcription and Suppresses Esophageal Carcinogenesis. Apigenin 0-8 interleukin 6 Homo sapiens 18-22 31572184-3 2019 We further demonstrated that apigenin, a nature flavone product of green plants, inhibited IL-6 transcription and gene expression in human esophagus cancer Eca-109 and Kyse-30 cells. Apigenin 29-37 interleukin 6 Homo sapiens 91-95 31572184-6 2019 Pretreatment of cells with IL-6 could completely reverse apigenin-induced cellular changes. Apigenin 57-65 interleukin 6 Homo sapiens 27-31 31572184-8 2019 Taken together, this study revealed for the first time that apigenin is a new IL-6 transcription inhibitor and that inhibiting IL-6 transcription is one of the mechanisms by which apigenin exhibits its anticancer effects. Apigenin 60-68 interleukin 6 Homo sapiens 78-82 31572184-8 2019 Taken together, this study revealed for the first time that apigenin is a new IL-6 transcription inhibitor and that inhibiting IL-6 transcription is one of the mechanisms by which apigenin exhibits its anticancer effects. Apigenin 180-188 interleukin 6 Homo sapiens 127-131 31306713-11 2019 Capsaicin remarkably enhanced the reepithelialization of ulcer tissues and showed strong anti-inflammatory effect by reducing the expressions of THF-alpha and IL-6. Capsaicin 0-9 interleukin 6 Homo sapiens 159-163 31571855-5 2019 The efficiency of the released DEX in reducing inflammation markers (tumor necrosis factor alpha and IL-6) produced by human monocytes and macrophages was similar to the pure drug at the same concentration without negative impacts on the viability and morphology of these cells. Dexamethasone 31-34 interleukin 6 Homo sapiens 101-105 30712124-9 2019 The interaction between H2O2 at 50 muM and LLLT at 4 J showed partially reversion of the higher levels of DNA oxidation, CASP 3, CASP 8, IL-1B, IL-6, and INFy induced by H2O2 exposure. Hydrogen Peroxide 24-28 interleukin 6 Homo sapiens 144-148 30861304-3 2019 In the present study, the role of ROS-mediated mechanisms in the concentration-dependent Si50 induction of CXCL8 and IL-6 responses was examined. Reactive Oxygen Species 34-37 interleukin 6 Homo sapiens 117-121 30861304-5 2019 Pre-treatment with the ROS inhibitors N-acetyl cysteine (NAC) and diphenyleneiodonium (DPI) partially attenuated CXCL8 and IL-6 responses to 200 microg/mL, but not to 100 microg/mL Si50. Reactive Oxygen Species 23-26 interleukin 6 Homo sapiens 123-127 30861304-5 2019 Pre-treatment with the ROS inhibitors N-acetyl cysteine (NAC) and diphenyleneiodonium (DPI) partially attenuated CXCL8 and IL-6 responses to 200 microg/mL, but not to 100 microg/mL Si50. Acetylcysteine 38-55 interleukin 6 Homo sapiens 123-127 30861304-5 2019 Pre-treatment with the ROS inhibitors N-acetyl cysteine (NAC) and diphenyleneiodonium (DPI) partially attenuated CXCL8 and IL-6 responses to 200 microg/mL, but not to 100 microg/mL Si50. Acetylcysteine 57-60 interleukin 6 Homo sapiens 123-127 30861304-10 2019 In conclusion, Si50-induced CXCL8 and IL-6 involved both ROS-dependent and ROS-independent mechanisms. Reactive Oxygen Species 57-60 interleukin 6 Homo sapiens 38-42 30861304-10 2019 In conclusion, Si50-induced CXCL8 and IL-6 involved both ROS-dependent and ROS-independent mechanisms. Reactive Oxygen Species 75-78 interleukin 6 Homo sapiens 38-42 31276858-7 2019 The calcium sensing receptor (CaSR) may be crucial for this recruitment as its expression and activity are increased by cytokines such as IL-6 and high extracellular calcium concentrations, respectively. Calcium 4-11 interleukin 6 Homo sapiens 138-142 31187425-9 2019 Multivariate analysis showed that low dialysate copeptin (beta = -0.30, p = 0.049) and high dialysate IL-6 (beta = + 0.40, p = 0.012) were independent determinants of higher D/P creatinine. Creatinine 178-188 interleukin 6 Homo sapiens 102-106 31229280-10 2019 Co-incubation of high-glucose-treated endothelial cells with milk extracts from group S15 improved cell viability compared with cells treated with high glucose only; it also reduced intracellular lipid peroxidation (144.3 +- 0.4 vs. 177.5 +- 1.9%), reactive oxygen species (141.3 +- 0.9 vs. 189.3 +- 4.7 optical density units), and cytokine release (tumor necrosis factor-alpha, IL-1beta, IL-6). Glucose 22-29 interleukin 6 Homo sapiens 389-393 31211861-7 2019 The results showed that esculetin suppressed histamine-induced expression and secretion of IL-6, IL-8, and MUC5AC in HNEpCs. esculetin 24-33 interleukin 6 Homo sapiens 91-95 31211861-7 2019 The results showed that esculetin suppressed histamine-induced expression and secretion of IL-6, IL-8, and MUC5AC in HNEpCs. Histamine 45-54 interleukin 6 Homo sapiens 91-95 31211861-10 2019 Inhibiting NF-kappaB pathway suppressed histamine-induced production of IL-6, IL-8, and MUC5AC in HNEpCs. Histamine 40-49 interleukin 6 Homo sapiens 72-76 31252119-4 2019 Moreover, ROS accelerate the translocation and phosphorylation of NF-kappaB in nucleic and promote the expression of inflammatory, such as IL-8 and IL-6. Reactive Oxygen Species 10-13 interleukin 6 Homo sapiens 148-152 31195185-6 2019 While neuroinflammation pathways were activated in both groups, key neuronal system pathways were systematically deactivated in the HSF group, including calcium, CREB and Opioid signaling. Calcium 153-160 interleukin 6 Homo sapiens 132-135 30712124-9 2019 The interaction between H2O2 at 50 muM and LLLT at 4 J showed partially reversion of the higher levels of DNA oxidation, CASP 3, CASP 8, IL-1B, IL-6, and INFy induced by H2O2 exposure. Hydrogen Peroxide 170-174 interleukin 6 Homo sapiens 144-148 31567972-6 2019 Levels of IL-6, IL-7, and monocyte chemoattractant protein 1 were higher with 5-aminosalicylic acid (5-ASA) + Azathioprine therapy than controls (P < .05). Mesalamine 78-99 interleukin 6 Homo sapiens 10-14 29687969-9 2019 CONCLUSIONS: Levels of serum hs-CRP, TNF-alpha and IL-6 are significantly elevated in patients with type 2 DM combined with essential hypertension, which are important factors affecting changes in blood glucose. Glucose 203-210 interleukin 6 Homo sapiens 51-55 31376399-7 2019 We demonstrate that the synergistic action of phosphate overload and IL-6 enhances senescence-associated calcification in a p53-dependent manner and is inhibited by an anti-aging agent (resveratrol) in a dose-dependent manner. Resveratrol 186-197 interleukin 6 Homo sapiens 69-73 31567972-6 2019 Levels of IL-6, IL-7, and monocyte chemoattractant protein 1 were higher with 5-aminosalicylic acid (5-ASA) + Azathioprine therapy than controls (P < .05). Mesalamine 101-106 interleukin 6 Homo sapiens 10-14 31309655-1 2019 Catechin in green tea might be able to reduce inflammatory mediators; therefore, in this study, we aimed to indicate green tea effects on inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6). Catechin 0-8 interleukin 6 Homo sapiens 240-253 31322196-5 2019 The expression levels of interleukin (IL)-6, IL-8 and monocyte chemoattractant protein-1 increased following treatment with S100A8 and S100A9, and the increase was significantly blocked by specific signaling pathway inhibitors, including toll-like receptor 4 inhibitor (TLR4i), rottlerin, PD98059, SB203580 and BAY-11-7085. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 289-296 interleukin 6 Homo sapiens 25-43 31146011-7 2019 Moreover, NaHS supplementation also decreased the TNF-alpha, IL-6 and MCP-1 in the serum of HHcy animals. sodium bisulfide 10-14 interleukin 6 Homo sapiens 61-65 31480578-5 2019 The Curcumin ASD demonstrated enhanced bioavailability by 11-fold and improved anti-inflammatory activities by the decrease in cytokine production (MMP-9, IL-1beta, IL-6, VEGF, MIP-2, and TNF-alpha) compared to the raw Curcumin. Curcumin 4-12 interleukin 6 Homo sapiens 165-169 31309655-1 2019 Catechin in green tea might be able to reduce inflammatory mediators; therefore, in this study, we aimed to indicate green tea effects on inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6). Catechin 0-8 interleukin 6 Homo sapiens 255-259 31211952-7 2019 Taken together, our data suggest that CDMP down-regulates genes encoding pro-inflammatory mediators and cytokines, such as iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 via NF-kappaB and JNK/AP-1 inactivation in LPS-induced RAW 264.7 macrophages. cdmp 38-42 interleukin 6 Homo sapiens 161-165 31341036-0 2019 Is there a role for prostanoid-mediated inhibition of IL-6 trans-signalling in the management of pulmonary arterial hypertension? Prostaglandins 20-30 interleukin 6 Homo sapiens 54-58 31341036-4 2019 cAMP can also inhibit IL-6-mediated endothelial dysfunction via the induction of SOCS3. Cyclic AMP 0-4 interleukin 6 Homo sapiens 22-26 31341036-5 2019 Thus, we propose that an important mechanism by which cAMP-mobilising prostanoid drugs limit PAH is by inhibiting IL-6-mediated pulmonary inflammation and remodelling via SOCS3 inhibition of IL-6 signalling. Cyclic AMP 54-58 interleukin 6 Homo sapiens 114-118 31341036-5 2019 Thus, we propose that an important mechanism by which cAMP-mobilising prostanoid drugs limit PAH is by inhibiting IL-6-mediated pulmonary inflammation and remodelling via SOCS3 inhibition of IL-6 signalling. Cyclic AMP 54-58 interleukin 6 Homo sapiens 191-195 31341036-5 2019 Thus, we propose that an important mechanism by which cAMP-mobilising prostanoid drugs limit PAH is by inhibiting IL-6-mediated pulmonary inflammation and remodelling via SOCS3 inhibition of IL-6 signalling. Prostaglandins 70-80 interleukin 6 Homo sapiens 114-118 31341036-5 2019 Thus, we propose that an important mechanism by which cAMP-mobilising prostanoid drugs limit PAH is by inhibiting IL-6-mediated pulmonary inflammation and remodelling via SOCS3 inhibition of IL-6 signalling. Prostaglandins 70-80 interleukin 6 Homo sapiens 191-195 31543817-9 2019 The glucocorticoid hydrocortisone caused substantial inhibition of the endotoxin-induced release of IL-26, IL-6, and IL-8, an effect paralleled by a decrease of the phosphorylation of NF-kappaB, p38, and ERK1/2. Hydrocortisone 19-33 interleukin 6 Homo sapiens 107-111 31129148-5 2019 IP1867B treatment mediated a potent suppression of the IL6/STAT3 and NF-kappaB pathways and observed a significant reduction in EGFR transcription and protein expression. ip1867b 0-7 interleukin 6 Homo sapiens 55-58 31211952-3 2019 Consistent with these results, CDMP also down-regulated inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta), and interleukin 6 (IL-6) at the protein and mRNA levels in LPS-treated RAW 264.7 macrophages. cdmp 31-35 interleukin 6 Homo sapiens 197-210 31211952-3 2019 Consistent with these results, CDMP also down-regulated inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta), and interleukin 6 (IL-6) at the protein and mRNA levels in LPS-treated RAW 264.7 macrophages. cdmp 31-35 interleukin 6 Homo sapiens 212-216 31216262-0 2019 Corrigendum to: SIAH1/ZEB1/IL-6 axis is involved in doxorubicin (Dox) resistance of osteosarcoma cells. Doxorubicin 52-63 interleukin 6 Homo sapiens 27-31 31216262-0 2019 Corrigendum to: SIAH1/ZEB1/IL-6 axis is involved in doxorubicin (Dox) resistance of osteosarcoma cells. Doxorubicin 65-68 interleukin 6 Homo sapiens 27-31 31437155-8 2019 CONCLUSION: Among HIV+ adults, current heavy alcohol use is associated with higher sCD14, IL-6 and D-dimer over time. Alcohols 45-52 interleukin 6 Homo sapiens 90-94 31462987-10 2019 Besides, high-glucose (25 mM) inhibited HRECs viability and induced oxidative stress, inflammation associated cytokines (TNF-alpha, IL-6 and IL-1beta) secretion and cell apoptosis, which were all reversed by synergistically overexpressing CKIP-1 and aggravated by knocking down CKIP-1. Glucose 14-21 interleukin 6 Homo sapiens 132-136 31375946-9 2019 The decreased ADA activity and the increase in A1 receptor expression may contribute to adenosine pro-tumor effects by increasing IL-6 and TNF-alpha and decreasing IL-17 and INF-gamma serum levels. Adenosine 88-97 interleukin 6 Homo sapiens 130-134 31282647-8 2019 Systemically administered METH (1 mg/kg) was found to specifically up-regulate expression of both CD11b (microglial activation marker) and the proinflammatory cytokine interleukin 6 (IL-6) mRNAs in the ventral tegmental area (VTA), but not in either the nucleus accumbens shell (NAc) or prefrontal cortex (PFC). Methamphetamine 26-30 interleukin 6 Homo sapiens 168-181 31282647-8 2019 Systemically administered METH (1 mg/kg) was found to specifically up-regulate expression of both CD11b (microglial activation marker) and the proinflammatory cytokine interleukin 6 (IL-6) mRNAs in the ventral tegmental area (VTA), but not in either the nucleus accumbens shell (NAc) or prefrontal cortex (PFC). Methamphetamine 26-30 interleukin 6 Homo sapiens 183-187 31282647-9 2019 Systemic administration of a nonopioid, blood-brain barrier permeable TLR4 antagonist (+)-naloxone inhibited METH-induced activation of microglia and IL-6 mRNA overexpression in VTA. Methamphetamine 109-113 interleukin 6 Homo sapiens 150-154 31282647-11 2019 Furthermore, intra-VTA injection of LPS-RS or IL-6 neutralizing antibody suppressed METH-induced elevation of extracellular NAc dopamine. Methamphetamine 84-88 interleukin 6 Homo sapiens 46-50 31282647-12 2019 Taken together, this series of studies demonstrate that METH-induced neuroinflammation is, at least in part, mediated by TLR4-IL6 signaling within the VTA, which has the downstream effect of elevating dopamine in the NAc shell. Methamphetamine 56-60 interleukin 6 Homo sapiens 126-129 31282647-12 2019 Taken together, this series of studies demonstrate that METH-induced neuroinflammation is, at least in part, mediated by TLR4-IL6 signaling within the VTA, which has the downstream effect of elevating dopamine in the NAc shell. Dopamine 201-209 interleukin 6 Homo sapiens 126-129 31154939-15 2019 Metformin treatment decreased inflammation, IL-6 levels, STAT3 activation, and human PA smooth muscle cell proliferation. Metformin 0-9 interleukin 6 Homo sapiens 44-48 31154939-16 2019 In vivo, in the supracoronary aortic banding+MetS animals, reducing IL-6, either by anti-IL-6 antibody or metformin treatment, reversed pulmonary vascular remodeling and improve PH due to LHD. Metformin 106-115 interleukin 6 Homo sapiens 68-72 31042404-7 2019 c/EBPbeta knockdown almost completely abrogated the cAMP-mediated IL-6 but not PDE4D gene expression. Cyclic AMP 52-56 interleukin 6 Homo sapiens 66-70 31211863-11 2019 An increased mRNA expression of IL-6, IL-8, and MCP-1 by FAEEs is key finding to suggest a metabolic basis of EtOH-induced inflammatory response. Ethanol 110-114 interleukin 6 Homo sapiens 32-36 31042404-5 2019 NHERF1 knockdown fully abrogated the ISO-, PGE2-, and FSK-induced IL-6 gene expression and cytokine production without affecting cAMP-mediated phosphodiesterase 4D (PDE4D) gene expression, phospho-cAMP response element-binding protein (p-CREB), and cAMP response element (CRE)-Luc, or PDGF-induced cyclin D1 expression. Dinoprostone 43-47 interleukin 6 Homo sapiens 66-70 30919933-7 2019 High levels of D-fructose compared to D-glucose led to activation of DCs in vitro by promoting interleukin (IL)-6 and IL-1beta production. Glucose 40-47 interleukin 6 Homo sapiens 95-113 31389609-10 2019 High glucose group had clearly increased the content of ROS (p<0.01), LDH (p<0.01), and interleukin-6 (IL-6) (p<0.01), but decreased the content of IL-10 (p<0.01). Glucose 5-12 interleukin 6 Homo sapiens 88-101 31389609-10 2019 High glucose group had clearly increased the content of ROS (p<0.01), LDH (p<0.01), and interleukin-6 (IL-6) (p<0.01), but decreased the content of IL-10 (p<0.01). Glucose 5-12 interleukin 6 Homo sapiens 103-107 31389609-12 2019 CONCLUSIONS: High glucose represses the activation of the Nrf2/anti-oxidation response element (ARE) signaling pathway in prostate cancer cells and increases the content of ROS, IL-6, and the expression of apoptotic proteins in the cells, thus promoting the apoptosis of prostate cancer cells. Glucose 18-25 interleukin 6 Homo sapiens 178-182 31069604-6 2019 DEX (1.000 nM) treatment in PBMC of SSc patients stimulated with anti-CD3 and anti-CD28 promoted a significant reduction in IL-2, IL-4, IL-6, IL-10, IL-17A, IFN-gamma, TNF, IL-1beta (p < 0.001 for all), and IL-17F (p = 0.023) cytokines levels. Dexamethasone 0-3 interleukin 6 Homo sapiens 136-140 31069604-8 2019 In PBMC from healthy volunteers, we observed that DEX treatment significantly reduced IL-4, IFN-gamma (p = 0.003 for both), IL-6, IL-10, IL-17A, and TNF (p = 0.002 for all) cytokines. Dexamethasone 50-53 interleukin 6 Homo sapiens 124-128 31934133-9 2019 High glucose significantly evoked MV generation, which contained increased protein level of IL-6, 8 and MCP-1. Glucose 5-12 interleukin 6 Homo sapiens 92-99 31103845-11 2019 Searching for possible mediators of these association, we found that levels of HDL-cholesterol (DeltaB = -0.148) partially mediated the association between ADs and IL-6. Cholesterol 83-94 interleukin 6 Homo sapiens 164-168 31250339-7 2019 The monocyte chemoattractant protein-1-to-creatinine ratio showed a significant correlation with hemoglobin A1c (P = 0.002) and inflammatory marker levels (interleukin-6, P = 0.005; tumor necrosis factor-alpha, P < 0.001). Creatinine 42-52 interleukin 6 Homo sapiens 156-169 31219767-9 2019 Our findings may have implications for the microvascular complications associated with T2DM.NEW & NOTEWORTHY Higher concentrations of serum factors, specifically Interleukin-6 and its soluble receptor found in individuals with type 2 diabetes (T2DM) appear to impair endothelial cell capillary-like network formation compared with those present in serum from individuals with impaired glucose tolerance and normal glucose tolerance. Glucose 389-396 interleukin 6 Homo sapiens 166-179 31441836-9 2019 CONCLUSION: The combined administration of TXA + Dexa significantly reduced the level of postoperative CRP and IL-6, relieve postoperative pain, ameliorate the incidence of POVN, provide additional analgesic and antiemetic effects, reduce postoperative fatigue, and improve ROM, without increasing the risk of complications in primary TKA. Dexamethasone 49-53 interleukin 6 Homo sapiens 111-115 30924020-7 2019 A tendency to increase the inflammatory markers IL-6 (p = 0.069) and MCP-1 (p = 0.067) was observed in those patients suffering from MS. An increase in the cardiovascular risk markers PAI-1 (p = 0.007) and triglycerides/HDL cholesterol ratio (p < 0.0001) was also found in the MS group. Triglycerides 206-219 interleukin 6 Homo sapiens 48-52 30924020-7 2019 A tendency to increase the inflammatory markers IL-6 (p = 0.069) and MCP-1 (p = 0.067) was observed in those patients suffering from MS. An increase in the cardiovascular risk markers PAI-1 (p = 0.007) and triglycerides/HDL cholesterol ratio (p < 0.0001) was also found in the MS group. Cholesterol 224-235 interleukin 6 Homo sapiens 48-52 31523190-10 2019 Meanwhile IL-6 induced gefitinib resistance and increased migration. Gefitinib 23-32 interleukin 6 Homo sapiens 10-14 30737481-3 2019 Exposure to neonatal alcohol resulted in acute increases in activation and inflammatory gene expression in hypothalamic microglia including tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6). Alcohols 21-28 interleukin 6 Homo sapiens 184-197 30737481-3 2019 Exposure to neonatal alcohol resulted in acute increases in activation and inflammatory gene expression in hypothalamic microglia including tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6). Alcohols 21-28 interleukin 6 Homo sapiens 199-203 30737481-7 2019 Investigation of possible epigenetic programming mechanisms by alcohol revealed neonatal alcohol decreased several repressive regulators of transcription in hypothalamic microglia, while concomitantly increasing histone H3 acetyl lysine 9 (H3K9ac) enrichment at TNF-alpha and IL-6 promoter regions. Alcohols 89-96 interleukin 6 Homo sapiens 276-280 31206225-7 2019 RESULTS: Curcumin supplementation had a significant effect on IL-6 levels and oxidative stress markers including TAC and MDA in crude model. Curcumin 9-17 interleukin 6 Homo sapiens 62-66 31206225-8 2019 After controlling the effects of confounders, curcumin supplementation had a substantial effect on inflammation (hs-CRP and IL-6) and oxidative stress (TAC) marker of adolescents. Curcumin 46-54 interleukin 6 Homo sapiens 124-128 31171361-0 2019 miR-374a/Myc axis modulates iron overload-induced production of ROS and the activation of hepatic stellate cells via TGF-beta1 and IL-6. Iron 28-32 interleukin 6 Homo sapiens 131-135 31171361-0 2019 miR-374a/Myc axis modulates iron overload-induced production of ROS and the activation of hepatic stellate cells via TGF-beta1 and IL-6. ros 64-67 interleukin 6 Homo sapiens 131-135 31171361-4 2019 miR-374a could target Myc, a co-transcription factor of both TGF-beta1 and IL-6, to negatively regulate Myc expression; FAC stimulation significantly suppressed miR-374a expression, whereas the suppressive effect of FAC stimulation on miR-374a expression could be reversed by ROS inhibitor NAC, indicating that miR-374a could be modulated by iron overload-induced ROS. ros 276-279 interleukin 6 Homo sapiens 75-79 31171361-4 2019 miR-374a could target Myc, a co-transcription factor of both TGF-beta1 and IL-6, to negatively regulate Myc expression; FAC stimulation significantly suppressed miR-374a expression, whereas the suppressive effect of FAC stimulation on miR-374a expression could be reversed by ROS inhibitor NAC, indicating that miR-374a could be modulated by iron overload-induced ROS. Iron 342-346 interleukin 6 Homo sapiens 75-79 31171361-4 2019 miR-374a could target Myc, a co-transcription factor of both TGF-beta1 and IL-6, to negatively regulate Myc expression; FAC stimulation significantly suppressed miR-374a expression, whereas the suppressive effect of FAC stimulation on miR-374a expression could be reversed by ROS inhibitor NAC, indicating that miR-374a could be modulated by iron overload-induced ROS. ros 364-367 interleukin 6 Homo sapiens 75-79 31171361-7 2019 In conclusion, we demonstrate a novel mechanism of miR-374a/Myc axis modulating iron overload-induced production of ROS and the activation of HSCs via TGF-beta1 and IL-6. Iron 80-84 interleukin 6 Homo sapiens 165-169 31171361-7 2019 In conclusion, we demonstrate a novel mechanism of miR-374a/Myc axis modulating iron overload-induced production of ROS and the activation of HSCs via TGF-beta1 and IL-6. ros 116-119 interleukin 6 Homo sapiens 165-169 31153641-0 2019 Increased hepcidin in hemorrhagic plaques correlates with iron-stimulated IL-6/STAT3 pathway activation in macrophages. Iron 58-62 interleukin 6 Homo sapiens 74-78 31153641-11 2019 In conclusion, our data indicate that hepcidin levels are increased in hemorrhagic plaques, which correlates with iron-stimulated IL-6/STAT3 pathway activation in macrophages. Iron 114-118 interleukin 6 Homo sapiens 130-134 31337349-14 2019 CONCLUSION: These results suggest that MTF inhibits IL-6-induced EMT, cell proliferation, and migration of primary breast cancer cells by preventing the activation of STAT3 and NF-kappaB. Metformin 39-42 interleukin 6 Homo sapiens 52-56 31396302-9 2019 IL-6 was an independent predictor of L-arginine/ADMA, VEGF-A of ADMA, G-CSF of L-arginine/SDMA, and GM-CSF of L-citrulline and SDMA. Arginine 37-47 interleukin 6 Homo sapiens 0-4 31396538-10 2019 Visfatin-induced inflammation and insulin resistance were regulated by JAK2/STAT3 and IKK/NF-kappaB signaling; together with AG490 or Bay 7082, visfatin significantly reduced mRNA levels of IL-6, TNF-alpha and IL-1beta and rescued insulin signaling. bay 7082 134-142 interleukin 6 Homo sapiens 190-194 31085401-3 2019 Herein, a highly sensitive and selective aptasensor for quantitative detection of interleukin-6 was developed by using a glassy carbon electrode modified with p-aminobenzoic acid, p-aminothiophenol and gold nanoparticles. Carbon 128-134 interleukin 6 Homo sapiens 82-95 31396302-9 2019 IL-6 was an independent predictor of L-arginine/ADMA, VEGF-A of ADMA, G-CSF of L-arginine/SDMA, and GM-CSF of L-citrulline and SDMA. Arginine 79-89 interleukin 6 Homo sapiens 0-4 31355138-10 2019 At the gene level, miR-153 targeted IDO1 expression and inhibited bladder cancer cell tryptophan metabolism through inhibiting IL6/STAT3/VEGF signaling. Tryptophan 86-96 interleukin 6 Homo sapiens 127-130 31296192-9 2019 Serum folate was negatively correlated with hs-CRP, TNF-alpha, and IL-6 (P < 0.05). Folic Acid 6-12 interleukin 6 Homo sapiens 67-71 31371988-9 2019 Furthermore, GRK2 down-regulation in beta2-AR activated M2-polarized macrophages activated the downstream cyclic adenosine monophosphate (cAMP)/protein kinase A/cAMP-response element binding protein and cAMP/interleukin-6/signal transducer and the activator of transcription 3 signaling pathways, contributing to the secretion of tumor-associated cytokines, and thus resulting in the promotion of malignant biological behavior in HCC cells. Cyclic AMP 138-142 interleukin 6 Homo sapiens 208-221 30959417-8 2019 Treatment of insulin resistant cells with SF or metformin alone decreased levels of reactive oxygen species (ROS), malondialdehyde (MDA), tumor necrosis factor (TNF-alpha) and interleukin-6 (IL-6); whereas antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) activity, as well as total antioxidant capacity (T-AOC) ability increased. Metformin 48-57 interleukin 6 Homo sapiens 176-189 30608861-6 2019 Exposing human lung fibroblasts to 150 muM hydrogen peroxide (H2O2) resulted in increased senescence-associated beta-galactosidase content and expression of p21 and IL-6, all of which are features of senescence. Hydrogen Peroxide 43-60 interleukin 6 Homo sapiens 165-169 30608861-6 2019 Exposing human lung fibroblasts to 150 muM hydrogen peroxide (H2O2) resulted in increased senescence-associated beta-galactosidase content and expression of p21 and IL-6, all of which are features of senescence. Hydrogen Peroxide 62-66 interleukin 6 Homo sapiens 165-169 31001673-10 2019 Of these, compared with glimepiride, canagliflozin 300 mg/day decreased plasma levels of TNF receptor 1 (TNFR1; 9.2%; p < 0.001), IL-6 (26.6%; p = 0.010), matrix metalloproteinase 7 (MMP7; 24.9%; p = 0.011) and fibronectin 1 (FN1; 14.9%; p = 0.055) during 2 years of follow-up. Canagliflozin 37-50 interleukin 6 Homo sapiens 133-137 31189128-0 2019 17beta-estradiol promotes endometrial cancer proliferation and invasion through IL-6 pathway. Estradiol 0-16 interleukin 6 Homo sapiens 80-84 31189128-3 2019 In this study, we provided evidence that 17beta-estradiol (E2) could significantly promote endometrial cancer cells viability, migration and invasion through activation of IL-6 pathway, which involved in its downstream pathway and target genes (p-Stat3, Bcl-2, Mcl-1, CyclinD1 and MMP2). Estradiol 41-57 interleukin 6 Homo sapiens 172-176 31295854-8 2019 Significantly (p < 0.01) lower total cholesterol (T-C) and low-density lipoprotein cholesterol (LDL-C) concentrations were observed in the GG IL6 rs1800795 genotype group. Cholesterol 40-51 interleukin 6 Homo sapiens 145-148 31022596-6 2019 RESULTS: Sal-B (10 muM) treatment significantly ameliorated LPS injury to MH7 A cells, as cell viability was increased, expression of p53 and p21 was repressed, apoptosis was inhibited, and the release of MCP-1, IL-6 and TNF-alpha was reduced. salvianolic acid B 9-14 interleukin 6 Homo sapiens 212-216 30918019-10 2019 The results demonstrated that CKLF1 enhanced the progression of HCC and prevented doxorubicin-induced apoptosis through activating the IL6/STAT3 pathway. Doxorubicin 82-93 interleukin 6 Homo sapiens 135-138 30919561-4 2019 In this study, it was demonstrated that epimagnolin A reduced phorbol-12-myristate-13-acetate (PMA)-induced IL-6 promoter activity and IL-6 production in human monocytic THP-1 cells. Tetradecanoylphorbol Acetate 62-93 interleukin 6 Homo sapiens 108-112 30919561-4 2019 In this study, it was demonstrated that epimagnolin A reduced phorbol-12-myristate-13-acetate (PMA)-induced IL-6 promoter activity and IL-6 production in human monocytic THP-1 cells. Tetradecanoylphorbol Acetate 95-98 interleukin 6 Homo sapiens 108-112 30919561-4 2019 In this study, it was demonstrated that epimagnolin A reduced phorbol-12-myristate-13-acetate (PMA)-induced IL-6 promoter activity and IL-6 production in human monocytic THP-1 cells. Tetradecanoylphorbol Acetate 95-98 interleukin 6 Homo sapiens 135-139 30959417-8 2019 Treatment of insulin resistant cells with SF or metformin alone decreased levels of reactive oxygen species (ROS), malondialdehyde (MDA), tumor necrosis factor (TNF-alpha) and interleukin-6 (IL-6); whereas antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) activity, as well as total antioxidant capacity (T-AOC) ability increased. Metformin 48-57 interleukin 6 Homo sapiens 191-195 31274789-10 2019 The Dex group had significantly lower interleukin (IL)-1beta levels in the lung tissue compared to the other groups (p < 0.05) and significantly lower IL-6 levels compared to the Ami and Mil groups (p < 0.05). Dexamethasone 4-7 interleukin 6 Homo sapiens 154-158 30536718-5 2019 We show that PGE2 -induced IL-6 protein secretion occurs via an EP2 -mediated pathway, in a manner independent of receptor-mediated effects on messenger RNA (mRNA) expression and temporal activation kinetics of the transcription factor cAMP response element binding. Dinoprostone 13-17 interleukin 6 Homo sapiens 27-31 30536718-4 2019 Using primary human airway smooth muscle (ASM) cells, we first focussed on the PGE2 -induced production of two cAMP-dependent proinflammatory mediators: interleukin 6 (IL-6) and cyclo-oxygenase 2 production. Dinoprostone 79-83 interleukin 6 Homo sapiens 153-166 30536718-4 2019 Using primary human airway smooth muscle (ASM) cells, we first focussed on the PGE2 -induced production of two cAMP-dependent proinflammatory mediators: interleukin 6 (IL-6) and cyclo-oxygenase 2 production. Dinoprostone 79-83 interleukin 6 Homo sapiens 168-172 30536718-4 2019 Using primary human airway smooth muscle (ASM) cells, we first focussed on the PGE2 -induced production of two cAMP-dependent proinflammatory mediators: interleukin 6 (IL-6) and cyclo-oxygenase 2 production. Cyclic AMP 111-115 interleukin 6 Homo sapiens 153-166 31261772-0 2019 Changes in Iron Metabolism Induced by Anti-Interleukin-6 Receptor Monoclonal Antibody are Associated with an Increased Risk of Infection. Iron 11-15 interleukin 6 Homo sapiens 43-56 31028753-6 2019 With respect to cytokine inductions, APCs treated with either Sal-HA or Sal-M2e induced significantly (p < .05) higher mRNA transcription levels of proinflammatory (IL-1beta, IL-6, IL-12 and IL-23), Th1 (IFN-gamma), Th17 (IL-17 and IL-21) and Th2 (IL-10 and TGF-beta) cytokines in T cells compared to Sal-NA or Salmonella alone treated APCs. sal-ha 62-68 interleukin 6 Homo sapiens 178-182 31316498-9 2019 The functional relevance of iron overloading was demonstrated by a marked induction of the expression of interleukin-6 in iron-treated macrophages. Iron 28-32 interleukin 6 Homo sapiens 105-118 31316498-9 2019 The functional relevance of iron overloading was demonstrated by a marked induction of the expression of interleukin-6 in iron-treated macrophages. Iron 122-126 interleukin 6 Homo sapiens 105-118 31316498-10 2019 Importantly, pre-treatment of cells with the iron-chelating agent deferoxamine completely abolished the hemin-dependent translocation of 5-LOX to the nuclear fraction, and significantly reverted its effect on interleukin-6 overexpression. Iron 45-49 interleukin 6 Homo sapiens 209-222 31293514-8 2019 There was a significant positive correlation between ASP levels with CRP (p < 0.01), testosterone (p < 0.01) and HOMA-IR (p < 0.01); IL-6 levels with CRP (p <0.01) and testosterone (p < 0.01) and MCP-1 with CRP (p < 0.01); testosterone (p < 0.01) and HOMA-IR (p < 0.02). Testosterone 180-192 interleukin 6 Homo sapiens 142-146 31293514-8 2019 There was a significant positive correlation between ASP levels with CRP (p < 0.01), testosterone (p < 0.01) and HOMA-IR (p < 0.01); IL-6 levels with CRP (p <0.01) and testosterone (p < 0.01) and MCP-1 with CRP (p < 0.01); testosterone (p < 0.01) and HOMA-IR (p < 0.02). Testosterone 180-192 interleukin 6 Homo sapiens 142-146 29925283-6 2019 The suppression of inflammation by testosterone were observed in patients with coronary artery disease, prostate cancer and diabetes mellitus through the increase in anti-inflammatory cytokines (IL-10) and the decrease in pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha). Testosterone 35-47 interleukin 6 Homo sapiens 260-264 31293514-9 2019 Conclusions: This post-hoc analysis revealed that 12 weeks of atorvastatin treatment significantly decreased the markers of adipose tissue dysfunction and inflammation, namely ASP, IL-6 and MCP-1 in obese women with PCOS. Atorvastatin 62-74 interleukin 6 Homo sapiens 181-185 31222133-2 2019 Because the cytokines TNFalpha and IL-6 are key signals in HFD- and SFA-induced proinflammatory responses that ultimately lead to systemic insulin resistance, the present study examined the roles of these cytokines in the feedback modulation of peripheral circadian clocks by the proinflammatory SFA, palmitate. Fatty Acids 68-71 interleukin 6 Homo sapiens 35-39 31222133-6 2019 These studies suggest that TNFalpha, IL-6 and other proinflammatory cytokines may mediate the feedback modulation of peripheral circadian clocks by SFA-induced inflammatory signaling. Fatty Acids 148-151 interleukin 6 Homo sapiens 37-41 31212679-5 2019 The C. turczaninowii extract attenuated the increased mRNA expression of IL-6, TNF-alpha, and CHOP in hASMCs under high glucose conditions. Glucose 120-127 interleukin 6 Homo sapiens 73-77 30336201-9 2019 Simultaneously, ethanol reduced the induction of IL-6 and increased prostaglandin E2 synthesis as well as hPDL-fibroblast-mediated osteoclastogenesis without affecting the RANK-L/OPG-system. Ethanol 16-23 interleukin 6 Homo sapiens 49-53 30488141-4 2019 Treatment with RSG ameliorated axonal injury, cell apoptosis, glia activation, and the release of inflammatory factors such as TNF-alpha, IL-1beta, and IL-6. Rosiglitazone 15-18 interleukin 6 Homo sapiens 152-156 31004595-10 2019 Araloside A concentration-dependently curbed the production of interleukin-6, interleukin-8, prostaglandin E2 and nitric oxide in MH7A cells. araloside A 0-11 interleukin 6 Homo sapiens 63-76 30365907-1 2019 Interleukin-6 (IL-6), IL-15, and heat shock protein 72 (Hsp72) are molecules that have significant metabolic effects on glucose and fat metabolism and a cell"s stress response. Glucose 120-127 interleukin 6 Homo sapiens 0-13 30365907-1 2019 Interleukin-6 (IL-6), IL-15, and heat shock protein 72 (Hsp72) are molecules that have significant metabolic effects on glucose and fat metabolism and a cell"s stress response. Glucose 120-127 interleukin 6 Homo sapiens 15-19 30365907-9 2019 Since these molecules are involved in regulating glucose and fat metabolism, significant increases of IL-6, IL-15, and soluble Hsp72 may have health benefits that may be associated with long-distance trail runs, which are becoming more popular worldwide. Glucose 49-56 interleukin 6 Homo sapiens 102-106 31223191-10 2019 Inflammatory cytokines, such as IL-6, and stress oxidative markers might play a role in underlying mechanisms modulating the glucose variability responses to exercise (clinicalTrials.gov NCT02262208). Glucose 125-132 interleukin 6 Homo sapiens 32-36 31153358-5 2019 RESULTS: The SNB with 0.75% ropivacaine not only decreased IL-6 levels in plasma 6 h after craniotomy but also decreased plasma CRP levels and increased plasma IL-10 levels 12 and 24 h after surgery compared to LA and routine analgesia. 1-(3-bromophenyl)-7-chloro-6-methoxy-3,4-dihydroisoquinoline 13-16 interleukin 6 Homo sapiens 59-63 31153358-5 2019 RESULTS: The SNB with 0.75% ropivacaine not only decreased IL-6 levels in plasma 6 h after craniotomy but also decreased plasma CRP levels and increased plasma IL-10 levels 12 and 24 h after surgery compared to LA and routine analgesia. Ropivacaine 28-39 interleukin 6 Homo sapiens 59-63 31102070-0 2019 Adrenal insufficiency treated with conventional hydrocortisone leads to elevated levels of Interleukin-6: a pilot study. Hydrocortisone 48-62 interleukin 6 Homo sapiens 91-104 30937698-6 2019 Conversely, Vitamin D increases glial tumor synthesis of neutrophins NGF and NT-3, the low affinity neurotrophin receptor p75NTR, IL-6 and VEGF, which may enhance glioma growth. Vitamin D 12-21 interleukin 6 Homo sapiens 130-134 30362543-7 2019 Gene ontology (GO) and pathway analysis indicated that these two upregulated tDRs were mainly involved in maintenance of stem cell population and cellular response to interleukin (IL)-6, which may be the underlying mechanism of hypoxia-induced tDRs that facilitate the doxorubicin resistance in TNBC. Doxorubicin 269-280 interleukin 6 Homo sapiens 167-185 30988370-5 2019 Herein the systematic removal of carbons from either the hydroxy fatty acid or fatty acid regions of the most studied FAHFA, palmitic acid ester of 9-hydroxystearic acid (9-PAHSA), was achieved and these synthetic, abridged analogs were tested for their ability to attenuate IL-6 production. Carbon 33-40 interleukin 6 Homo sapiens 275-279 30334569-5 2019 Metformin also significantly ( p < 0.05) inhibited TAA-induced HIF-1alpha, mTOR, the profibrogenic biomarker alpha-smooth muscle actin, tissue inhibitor of metalloproteinases-1, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), alanine aminotransferase (ALT) and aspartate aminotransferase in harvested liver homogenates and blood samples. Metformin 0-9 interleukin 6 Homo sapiens 219-232 30334569-5 2019 Metformin also significantly ( p < 0.05) inhibited TAA-induced HIF-1alpha, mTOR, the profibrogenic biomarker alpha-smooth muscle actin, tissue inhibitor of metalloproteinases-1, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), alanine aminotransferase (ALT) and aspartate aminotransferase in harvested liver homogenates and blood samples. Metformin 0-9 interleukin 6 Homo sapiens 234-238 30804456-3 2019 Here we show that the IL-6/STAT3 inflammatory signaling axis induces the deacetylation of FRA1 at the Lys-116 residue located within its DNA-binding domain. Lysine 102-105 interleukin 6 Homo sapiens 22-26 31213851-0 2019 Deferoxamine-induced high expression of TfR1 and DMT1 enhanced iron uptake in triple-negative breast cancer cells by activating IL-6/PI3K/AKT pathway. Iron 63-67 interleukin 6 Homo sapiens 128-132 31028903-5 2019 Exposure of these cells to lipogenic (insulin, glucose, fatty acids) and pro-inflammatory factors (IL-1beta, TNF-alpha, TGF-beta) resulted in a characteristic NASH response, as indicated by intracellular lipid accumulation, modulation of NASH-specific gene expression, increased caspase-3/7 activity and the expression and/or secretion of inflammatory markers, including CCL2, CCL5, CCL7, CCL8, CXCL5, CXCL8, IL1a, IL6 and IL11. Fatty Acids 56-67 interleukin 6 Homo sapiens 415-418 31159519-8 2019 Similarly,the protein levels as well as mRNA expression of IL-6 and IL-17 in patients with iron overload were significantly higher than those in non-iron overload group (P<0.01 both in PB and BM). Iron 91-95 interleukin 6 Homo sapiens 59-63 31159519-9 2019 Conclusions: As hematopoietic regulators secreted by Th17 cells, the expression of IL-6 and IL-17 in MDS patients with iron overload are elevated. Iron 119-123 interleukin 6 Homo sapiens 83-87 31213851-10 2019 The activated IL-6/PI3K/AKT pathway upregulated the expression of iron-uptake related proteins, TfR1 and DMT1, leading to increased iron uptakes. Iron 66-70 interleukin 6 Homo sapiens 14-18 31213851-10 2019 The activated IL-6/PI3K/AKT pathway upregulated the expression of iron-uptake related proteins, TfR1 and DMT1, leading to increased iron uptakes. Iron 132-136 interleukin 6 Homo sapiens 14-18 30996116-6 2019 DOX influenced inflammatory responses by inducing a significant increase in the expression of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and cyclooxigenase-2 (COX-2), of inflammatory interleukins (IL), such as interleukin-6 (IL-6) and interleukin-8 (IL-8), and the inflammatory proteins mediators metalloproteinase-2 and metalloproteinase-9 (MMP2 and MMP9). Doxorubicin 0-3 interleukin 6 Homo sapiens 243-256 31138279-10 2019 Our hypothesis is that anesthesia with sevoflurane will result in a weaker proinflammatory response compared to anesthesia with propofol, with lower circulating levels of IL-6 and other proinflammatory mediators, and increased macrophage differentiation into the M2 phenotype in adipose tissue. Sevoflurane 39-50 interleukin 6 Homo sapiens 171-175 31070650-6 2019 Furthermore, TPA obviously assuaged TNF-alpha-evoked up-regulation of IL-8 and IL-6 expression, down-regulation of occludin and ZO-3 expression, and markedly suppressed the activation and protein expression of NF-kappaB p65. Tetradecanoylphorbol Acetate 13-16 interleukin 6 Homo sapiens 79-83 31043452-3 2019 miRNA-608 has been reported to interact with interleukin-6 and affect innate immunity. mirna-608 0-9 interleukin 6 Homo sapiens 45-58 31100089-9 2019 catechin inhibited the gene expression of pro-inflammatory cytokines including IL-1alpha, IL-1beta, IL-6, IL-12p35, and inflammatory enzymes including iNOS and COX-2, but enhanced the gene expression of anti-inflammatory cytokines including IL-4 and IL-10. Catechin 0-8 interleukin 6 Homo sapiens 100-104 30996116-6 2019 DOX influenced inflammatory responses by inducing a significant increase in the expression of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and cyclooxigenase-2 (COX-2), of inflammatory interleukins (IL), such as interleukin-6 (IL-6) and interleukin-8 (IL-8), and the inflammatory proteins mediators metalloproteinase-2 and metalloproteinase-9 (MMP2 and MMP9). Doxorubicin 0-3 interleukin 6 Homo sapiens 258-262 30648905-5 2019 In both cell types, challenge with arachidonic acid (AA) (omega-6 PUFA) and poly(I:C) or LTA led to substantially greater IL-6 and CXCL8 release than either challenge alone, demonstrating synergy. Arachidonic Acid 35-51 interleukin 6 Homo sapiens 122-126 30648905-6 2019 In epithelial cells, palmitic acid (SFA) combined with poly(I:C) also led to greater IL-6 release. Fatty Acids 36-39 interleukin 6 Homo sapiens 85-89 31092431-8 2019 CONCLUSION: Plasmatic doses of ASA and celecoxib altered the expression of IL6 and the gene expression of chemokines (ligands and receptors) and cytokines in a dose- and time-dependent manner. Aspirin 31-34 interleukin 6 Homo sapiens 75-78 30779630-3 2019 Using interval-based cycling in healthy young men, swimming exercise in mice, and electrical stimulation of primary human muscle cells, we explored the role of lactate production in muscular IL-6 release during exercise. Lactic Acid 160-167 interleukin 6 Homo sapiens 191-195 30954271-10 2019 Multiplex cytokine/chemokine array revealed enhanced levels of both IL-6 and TNF-alpha due to rfhSP-A treatment in the case of both IAV subtypes tested, while no significant effect was seen in the case of IL-12. rfhsp-a 94-101 interleukin 6 Homo sapiens 68-72 30729713-2 2019 The aim of this study is to determine the clinical factors of vitamin D deficiency in multi-ethnic Malaysian RA patients and its association with disease activity, functional disability and serum IL-6 levels. Vitamin D 62-71 interleukin 6 Homo sapiens 196-200 30811636-8 2019 Lactate mediated part of the crosstalk between tumor cells and Mphis, promoting secretion of IL-1beta, IL-10, IL-6, and up-regulation of hypoxia induced factor-1alpha expression, and down-regulation of p65-NFkappaB phosphorylation in Mphis. Lactic Acid 0-7 interleukin 6 Homo sapiens 110-114 30807628-14 2019 Human calvarial osteoblasts secreted IL-6 only during the first 24 hours and only in the highest titanium concentration, whereas human gingival fibroblasts secreted IL-6 during the entire period. Titanium 97-105 interleukin 6 Homo sapiens 37-41 30807628-15 2019 The lowest titanium concentration showed stronger secretion of IL-6 compared to control. Titanium 11-19 interleukin 6 Homo sapiens 63-67 30416026-12 2019 Furthermore, amiodarone inhibited postoperative interleukin-6 and tumor necrosis factor-alpha production. Amiodarone 13-23 interleukin 6 Homo sapiens 48-93 30570131-5 2019 Blockade of the IL-6 receptor subunit gp130 ameliorated tissue injury, substantiating the importance of deregulated PGC-1alpha/p65/IL-6 signaling in obesity and acute pancreatitis. 2-phenyl-5,5-dimethyltetrahydro-1,4-oxazine 38-43 interleukin 6 Homo sapiens 16-20 30835899-4 2019 Treatment with iron (ferric ammonium citrate, FAC) led to increased expression levels of M1 markers: CCL2, CD14, iNOS, IL-1beta, IL-6, and TNF-alpha; it also increased protein levels of CD68, TNF-alpha, IL-1beta, and IL-6 by flow cytometry. Iron 15-19 interleukin 6 Homo sapiens 129-133 30835899-4 2019 Treatment with iron (ferric ammonium citrate, FAC) led to increased expression levels of M1 markers: CCL2, CD14, iNOS, IL-1beta, IL-6, and TNF-alpha; it also increased protein levels of CD68, TNF-alpha, IL-1beta, and IL-6 by flow cytometry. Iron 15-19 interleukin 6 Homo sapiens 217-221 30835899-11 2019 Furthermore, NAFLD patients with hepatic RES iron deposition had increased hepatic gene expression levels of M1 markers, IL-6, IL-1beta, and CD40 and reduced gene expression of an M2 marker, TGM2, relative to patients with hepatocellular iron deposition pattern. Iron 45-49 interleukin 6 Homo sapiens 121-125 30570131-5 2019 Blockade of the IL-6 receptor subunit gp130 ameliorated tissue injury, substantiating the importance of deregulated PGC-1alpha/p65/IL-6 signaling in obesity and acute pancreatitis. 2-phenyl-5,5-dimethyltetrahydro-1,4-oxazine 38-43 interleukin 6 Homo sapiens 131-135 31083166-4 2019 Spinal and IV morphine substantially increased IL-6 production, whereas epidural morphine hindered IL-10 and GM-CSF production. Morphine 14-22 interleukin 6 Homo sapiens 47-51 30753845-8 2019 In PBMCs, exposure to these steroids resulted in the increase of mRNA and secreted protein levels of IL-1beta, TNFalpha, and IL-6 cytokines, as well as in the increase of INFgamma mRNA level, decrease of IL-2 mRNA level, increase of TGFbeta mRNA level, and decrease of IL-4 mRNA and IL-10 secreted protein levels. Steroids 28-36 interleukin 6 Homo sapiens 125-129 31080186-11 2019 Mechanistically, FXT suppressed the IL-6-induced phosphorylation of tyrosine residue (Tyr705) of signal transducer and activator of transcription 3 (STAT3) probably by binding to STAT3. Tyrosine 68-76 interleukin 6 Homo sapiens 36-40 31078158-4 2019 The effect of ATRA-As2O3 combination on the expressions of IL-6 and TNF-alpha in NB4 cells was determined using ELISA kits, while its effect on the quality of life of 25 acute promyelocytic leukemia patients admitted to our hospital was scored, as an index of prognosis. atra-as2o3 14-24 interleukin 6 Homo sapiens 59-63 31068940-5 2019 In particular, we found that CD28-activated RelA/NF-kappaB induces the expression of IL-6 that, in a positive feedback loop, mediates the activation and nuclear translocation of tyrosine phosphorylated STAT3 (pSTAT3). Tyrosine 178-186 interleukin 6 Homo sapiens 85-89 30896163-4 2019 ( R)-1 efficiently inhibited the lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6), while ( S)-1 produced no significant anti-inflammatory effect. Arginine 2-5 interleukin 6 Homo sapiens 125-138 30896163-4 2019 ( R)-1 efficiently inhibited the lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6), while ( S)-1 produced no significant anti-inflammatory effect. Arginine 2-5 interleukin 6 Homo sapiens 140-144 31008484-5 2019 The results showed that, PGE2 increased interleukin 6 (IL-6) and tumor necrosis factor alpha (TNFalpha) output, decreased chemokine (c-x-c motif) ligand 8 (CXCL8) output in a dose-dependent manner, but had no effect on IL-1beta and chemokine (c-c motif) ligand 2 (CCL-2) secretion of HUSMCs. Dinoprostone 25-29 interleukin 6 Homo sapiens 40-53 31008484-5 2019 The results showed that, PGE2 increased interleukin 6 (IL-6) and tumor necrosis factor alpha (TNFalpha) output, decreased chemokine (c-x-c motif) ligand 8 (CXCL8) output in a dose-dependent manner, but had no effect on IL-1beta and chemokine (c-c motif) ligand 2 (CCL-2) secretion of HUSMCs. Dinoprostone 25-29 interleukin 6 Homo sapiens 55-59 30664962-10 2019 Pyrazinib (P3) significantly reduced the secretions of IL-6 (p = 0.0006), IL-8 (p = 0.0488), and IL-4 (p = 0.0111) in OE33R cells. SCHEMBL9791651 0-9 interleukin 6 Homo sapiens 55-59 30986261-13 2019 In addition, ATRA treatment decreased the levels of IL4, IL6 and TNFalpha in A549 cells, whereas it increased IL4 and TNFalpha levels in PTGDR-transfected cells. Tretinoin 13-17 interleukin 6 Homo sapiens 57-60 31010006-5 2019 Based on alterations in morphology, modulation of capillary formation, and changes in endothelial and mesenchymal marker profile, our findings demonstrate that higher levels of tumor growth factor-betas and interleukin-6 enhance cancer-associated fibroblast-like cell formation through endothelial-mesenchymal transition and that nonsteroidal anti-inflammatory drug treatment (aspirin and ibuprofen) is able to inhibit this phenomenon. Aspirin 377-384 interleukin 6 Homo sapiens 207-220 31010006-5 2019 Based on alterations in morphology, modulation of capillary formation, and changes in endothelial and mesenchymal marker profile, our findings demonstrate that higher levels of tumor growth factor-betas and interleukin-6 enhance cancer-associated fibroblast-like cell formation through endothelial-mesenchymal transition and that nonsteroidal anti-inflammatory drug treatment (aspirin and ibuprofen) is able to inhibit this phenomenon. Ibuprofen 389-398 interleukin 6 Homo sapiens 207-220 30992036-5 2019 Interleukin-6 was also found to be a predictor of high cfDNA (>= 2.84 microg/mL, upper quartile) along with glucose. Glucose 111-118 interleukin 6 Homo sapiens 0-13 31105821-6 2019 Notably, our findings indicate that sitagliptin possesses an anti-inflammatory effect against H/R-induced expression of IL-6, IL-8, and TNF-alpha as well as secretion of HMGB1. r 96-97 interleukin 6 Homo sapiens 120-124 30760523-9 2019 Moreover, thrombin- and histamine-stimulated interleukin-6 production required both TAB1-TAB2 and TAB1-TAB3 in HUVEC. Histamine 24-33 interleukin 6 Homo sapiens 45-58 30831022-6 2019 IL-6 was significantly correlated with HULIS (as the main fraction of WSOC with oxygenated carbohydrate structures characteristic), Pb, and endotoxin. Carbohydrates 91-103 interleukin 6 Homo sapiens 0-4 30782482-9 2019 Analysis of the SMC supernatants by ELISA revealed CD-induced release of the senescence-associated cytokines IL-6 and MCP-1 in native and IFN-gamma-primed SMC, whereas no secretion of Interleukin-(IL) 1alpha and IL-1beta secretion were observed. Cadmium 51-53 interleukin 6 Homo sapiens 109-113 30595477-8 2019 Also, IL-6 blockade increased cholesterol levels, an effect not reversed by exercise. Cholesterol 30-41 interleukin 6 Homo sapiens 6-10 30631154-3 2019 Mechanistically, high glucose, TGF-beta, CTGF, SHH, and IL-6 induce the expression of a long non-coding RNA, GAEA (Glucose Aroused for EMT Activation), which associates with an RNA-binding E3 ligase, MEX3C, and enhances its enzymatic activity, leading to the K27-linked polyubiquitination of PTEN. Glucose 115-122 interleukin 6 Homo sapiens 56-60 31001483-7 2019 In addition, the current study demonstrated that phosphorylation at Serine (Ser) 387 site was required for recruitment of Ago2-containing miRISC to IL6 mRNA and BAG3 knockdown facilitated Ago2 loading to IL6 mRNA via increasing its phosphorylation at Ser 387. Serine 68-74 interleukin 6 Homo sapiens 148-151 31001483-7 2019 In addition, the current study demonstrated that phosphorylation at Serine (Ser) 387 site was required for recruitment of Ago2-containing miRISC to IL6 mRNA and BAG3 knockdown facilitated Ago2 loading to IL6 mRNA via increasing its phosphorylation at Ser 387. Serine 68-74 interleukin 6 Homo sapiens 204-207 31001483-7 2019 In addition, the current study demonstrated that phosphorylation at Serine (Ser) 387 site was required for recruitment of Ago2-containing miRISC to IL6 mRNA and BAG3 knockdown facilitated Ago2 loading to IL6 mRNA via increasing its phosphorylation at Ser 387. Serine 68-71 interleukin 6 Homo sapiens 148-151 31001483-7 2019 In addition, the current study demonstrated that phosphorylation at Serine (Ser) 387 site was required for recruitment of Ago2-containing miRISC to IL6 mRNA and BAG3 knockdown facilitated Ago2 loading to IL6 mRNA via increasing its phosphorylation at Ser 387. Serine 68-71 interleukin 6 Homo sapiens 204-207 31001483-7 2019 In addition, the current study demonstrated that phosphorylation at Serine (Ser) 387 site was required for recruitment of Ago2-containing miRISC to IL6 mRNA and BAG3 knockdown facilitated Ago2 loading to IL6 mRNA via increasing its phosphorylation at Ser 387. Serine 76-79 interleukin 6 Homo sapiens 148-151 31001483-7 2019 In addition, the current study demonstrated that phosphorylation at Serine (Ser) 387 site was required for recruitment of Ago2-containing miRISC to IL6 mRNA and BAG3 knockdown facilitated Ago2 loading to IL6 mRNA via increasing its phosphorylation at Ser 387. Serine 76-79 interleukin 6 Homo sapiens 204-207 31057960-3 2019 It aimed to demonstrate the changes in serum level of IL-6, ferritin level, and hematological parameters in different groups of patients with RA and to find out the potential correlation between serum level of IL-6 and ferritin level and the relationship between serum level of IL-6 and iron status. Iron 287-291 interleukin 6 Homo sapiens 210-214 31057960-3 2019 It aimed to demonstrate the changes in serum level of IL-6, ferritin level, and hematological parameters in different groups of patients with RA and to find out the potential correlation between serum level of IL-6 and ferritin level and the relationship between serum level of IL-6 and iron status. Iron 287-291 interleukin 6 Homo sapiens 210-214 30935522-6 2019 DISCUSSION: GTP play a role in reducing TNF-alpha, Interleukin 1beta (IL-1beta), IL-6, IL-8, and 17; downregulate cyclooxygenase-mediated I kappa B kinase and transcription of NFkappaB. Guanosine Triphosphate 12-15 interleukin 6 Homo sapiens 81-85 30585832-9 2019 In contrast, acetylsalicylic acid treatment resulted in enhanced plasma levels of tumor necrosis factor-alpha (+53%; p = 0.02), interleukin-6 (+91%; p = 0.03), and interleukin-8 (+42%; p = 0.02) upon the second challenge, whereas plasma levels of the key antiinflammatory cytokine interleukin-10 were attenuated (-40%; p = 0.003). Aspirin 13-33 interleukin 6 Homo sapiens 128-141 30745139-7 2019 We hypothesized that interleukin-6 is secreted primarily by non-neoplastic cells at MF skin sites, leading to release of copper by the liver. Copper 121-127 interleukin 6 Homo sapiens 21-34 30906451-7 2019 The positive rates of NF-kappaB, IL-6 and IL-8 at different time-points were lower in patients of the puerarin group than in those of the control group (and the differences at T3 were statistically significant). puerarin 102-110 interleukin 6 Homo sapiens 33-37 30609183-5 2019 BPA promoted the generation of proinflammatory cytokines IL-1beta, IL-6, and TNFalpha in a concentration-dependent manner (P < 0.05). bisphenol A 0-3 interleukin 6 Homo sapiens 67-71 30747999-9 2019 Real-time quantitative polymerase chain reaction results indicated a trend toward lower expression of inflammatory markers IL-1beta and IL-6 and transforming growth factor beta after 3 weeks of treatment with rapamycin and curcumin compared to vehicle. Sirolimus 209-218 interleukin 6 Homo sapiens 136-140 30747999-9 2019 Real-time quantitative polymerase chain reaction results indicated a trend toward lower expression of inflammatory markers IL-1beta and IL-6 and transforming growth factor beta after 3 weeks of treatment with rapamycin and curcumin compared to vehicle. Curcumin 223-231 interleukin 6 Homo sapiens 136-140 30623574-2 2019 Proinflammatory cytokines IL-6 and IL-8 are related to steroid-insensitive asthma. Steroids 55-62 interleukin 6 Homo sapiens 26-30 30906451-10 2019 Puerarin preconditioning can reduce the NF-kappaB activation and the overexpression of IL-6 and IL-8 in neutrophils, and it inhibits the release of myocardial enzyme cTnI and CK-MB reflecting myocardial cell protection. puerarin 0-8 interleukin 6 Homo sapiens 87-91 30716431-8 2019 Multiple genes were upregulated in HCASMCs in response to HOCl-modified HCASMC-ECM including interleukin-6 (IL-6), fibronectin (FN1) and matrix-metalloproteinases (MMPs). Hypochlorous Acid 58-62 interleukin 6 Homo sapiens 93-106 30716431-8 2019 Multiple genes were upregulated in HCASMCs in response to HOCl-modified HCASMC-ECM including interleukin-6 (IL-6), fibronectin (FN1) and matrix-metalloproteinases (MMPs). Hypochlorous Acid 58-62 interleukin 6 Homo sapiens 108-112 30729671-7 2019 Exogenous Pros1 inhibited p.g-LPS-induced production of TNF-alpha, IL-6, IL-1beta, MMP9/2 and RANKL in a Tyro3-dependent manner as revealed by PCR, Western blot analysis, ELISA and gelatin zymography. p.g-lps 26-33 interleukin 6 Homo sapiens 67-71 30724633-11 2019 IL-1beta and IL-6 were induced by nano-SiO2, and the IL-1beta treatment with 20 muM of I-kappaBalpha phosphorylation inhibitor (PD98059) and 20 muM of ERK1/2 inhibitor (BAY11-7082) for 1 h was significantly lower than that of the control group in A549 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 128-135 interleukin 6 Homo sapiens 13-17 30317657-0 2019 Nicotine stimulates IL-6 expression by activating the AP-1 and STAT-3 pathways in human endothelial EA.hy926 cells. Nicotine 0-8 interleukin 6 Homo sapiens 20-24 30317657-2 2019 In this study, we investigated the effects of nicotine, a major psychoactive compound in cigarette smoke, on IL-6 expression and EA.hy926 endothelial cell invasion. Nicotine 46-54 interleukin 6 Homo sapiens 109-113 30317657-3 2019 Nicotine stimulated IL-6 expression via the activator protein 1 (AP-1) transcription factor. Nicotine 0-8 interleukin 6 Homo sapiens 20-24 30317657-4 2019 Pharmacological inhibition and mutagenesis studies indicated that p38 mitogen-activated protein kinase (MAPK) mediated the IL-6-induced upregulation of nicotine in EA.hy926 cells. Nicotine 152-160 interleukin 6 Homo sapiens 123-127 30317657-5 2019 Furthermore, the antioxidant compound N-acetyl-cysteine eliminated the nicotine-activated production of reactive oxygen species (ROS) and inhibited signal transducer and activator of transcription 3 (STAT-3) phosphorylation; these two mechanisms mediated the upregulation of IL-6 expression by nicotine. Acetylcysteine 38-55 interleukin 6 Homo sapiens 275-279 30317657-5 2019 Furthermore, the antioxidant compound N-acetyl-cysteine eliminated the nicotine-activated production of reactive oxygen species (ROS) and inhibited signal transducer and activator of transcription 3 (STAT-3) phosphorylation; these two mechanisms mediated the upregulation of IL-6 expression by nicotine. Nicotine 71-79 interleukin 6 Homo sapiens 275-279 30317657-6 2019 In addition, the EA.hy926 cells treated with nicotine displayed markedly enhanced invasiveness due to IL-6 upregulation. Nicotine 45-53 interleukin 6 Homo sapiens 102-106 30317657-7 2019 Our data demonstrate that nicotine induced IL-6 expression, which, in turn, enhanced the invasiveness of endothelial EA.hy926 cells, via activation of the p38 MAPK/AP-1 and ROS/STAT-3 signaling pathways. Nicotine 26-34 interleukin 6 Homo sapiens 43-47 30404019-6 2019 ATP-induced IL-6 production was significantly inhibited by p38 inhibitors, SB203580, and doramapimod. Adenosine Triphosphate 0-3 interleukin 6 Homo sapiens 12-16 30404019-3 2019 We identified that hypoxia enhanced ATP release and that extracellular ATP enhanced IL-6 production more significantly in SSc fibroblasts than in normal fibroblasts. Adenosine Triphosphate 71-74 interleukin 6 Homo sapiens 84-88 30404019-7 2019 Collagen type I production in SSc fibroblasts by ATP-induced IL-6/IL-6 receptor trans-signaling was inhibited by kaempferol and SB203580. Adenosine Triphosphate 49-52 interleukin 6 Homo sapiens 61-65 30404019-5 2019 Nonselective P2 receptor antagonist and selective P2Y2 receptor antagonists, kaempferol and AR-C118925XX, significantly inhibited ATP-induced IL-6 production and phosphorylation of p38 in SSc fibroblasts. Adenosine Triphosphate 130-133 interleukin 6 Homo sapiens 142-146 30404019-9 2019 These results suggest that vasculopathy-induced hypoxia and oxidative stress might enhance ATP release in the dermis in SSc and that extracellular ATP-induced phosphorylation of p38 via P2Y2 receptor might enhance IL-6 and collagen type I production in SSc fibroblasts. Adenosine Triphosphate 147-150 interleukin 6 Homo sapiens 214-218 30295316-16 2019 Vitamin D inhibited IL-6 and IL-8 production stimulated by G-HSA or HSA + IL-1beta or IL-1beta + IL-17. Vitamin D 0-9 interleukin 6 Homo sapiens 20-24 30414721-9 2019 In the psychosis group, levels of IL-6 correlated positively with IgA anti-LPS antibodies and negatively correlated with vitamin D. Vitamin D 121-130 interleukin 6 Homo sapiens 34-38 30678901-8 2019 Further, the comparative relative expression profiling of the candidate genes were showed significant (p < 0.05) down-regulation of IL6, BCL2, p53, and MMP9 in the BRM270 NPs treated cells, compared to the free BRM270 and doxorubicin. Doxorubicin 225-236 interleukin 6 Homo sapiens 135-138 29932015-6 2019 Moreover, in vitro, we treated cells with IL-6 to simulate inflammatory microenvironment and found that glucose uptake, lactate production, and lactate dehydrogenase activity increased dramatically, mirroring what were observed in vivo. Glucose 104-111 interleukin 6 Homo sapiens 42-46 29932015-6 2019 Moreover, in vitro, we treated cells with IL-6 to simulate inflammatory microenvironment and found that glucose uptake, lactate production, and lactate dehydrogenase activity increased dramatically, mirroring what were observed in vivo. Lactic Acid 120-127 interleukin 6 Homo sapiens 42-46 29932015-8 2019 With the inhibition of STAT3/c-Myc signaling, meanwhile, the upregulation of both cell glucose uptake and lactate production by IL-6 pretreatment was reduced simultaneously. Glucose 87-94 interleukin 6 Homo sapiens 128-132 29932015-8 2019 With the inhibition of STAT3/c-Myc signaling, meanwhile, the upregulation of both cell glucose uptake and lactate production by IL-6 pretreatment was reduced simultaneously. Lactic Acid 106-113 interleukin 6 Homo sapiens 128-132 30783936-8 2019 The changing levels of As, Zn and Se seems to affect the severity of inflammatory reactions based on IL-6, IL-10 and TNF-alpha levels (r = 0.755, r = 0.679 and r = 0.617, respectively, for all p < 0.01). Zinc 27-29 interleukin 6 Homo sapiens 101-105 30710569-7 2019 miR-142-3p inhibitor combined with AC9 siRNA showed shorter axon length, the expression of AC9, cAMP, p-CREB, IL-6, and GAP43 was decreased, and the expression of GTP-RhoA was increased. Guanosine Triphosphate 163-166 interleukin 6 Homo sapiens 110-114 30414721-10 2019 CONCLUSIONS: Our findings show a significant correlation between IL-6, anti-LPS antibodies and vitamin D deficiency in psychosis, suggesting the existence of multiple potential pathways related to IL-6 elevation in psychosis, and therefore multiple potential strategies for risk mitigation. Vitamin D 95-104 interleukin 6 Homo sapiens 65-69 30414721-10 2019 CONCLUSIONS: Our findings show a significant correlation between IL-6, anti-LPS antibodies and vitamin D deficiency in psychosis, suggesting the existence of multiple potential pathways related to IL-6 elevation in psychosis, and therefore multiple potential strategies for risk mitigation. Vitamin D 95-104 interleukin 6 Homo sapiens 197-201 31019654-6 2019 ROS production reduced the nuclear phosphorylation levels of Stat3 and secreted IL-6 levels in the mammospheres. Reactive Oxygen Species 0-3 interleukin 6 Homo sapiens 80-84 30971879-8 2019 (3) In CSF, the IL-6 level was increased as the iron level was elevated in the PD-TD group (r = 0.308, P = 0.022). Iron 48-52 interleukin 6 Homo sapiens 16-20 30984167-12 2019 Results: Tofacitinib and baricitinib decreased the IL-6 release of RASF stimulated with oncostatin M. tofacitinib 9-20 interleukin 6 Homo sapiens 51-55 30677511-7 2019 BPA treatment can also increase the expression of tumor necrosis factor alpha (TNFalpha) and interleukin-6 (IL-6) via an Ang II dependent manner. bisphenol A 0-3 interleukin 6 Homo sapiens 93-106 30677511-7 2019 BPA treatment can also increase the expression of tumor necrosis factor alpha (TNFalpha) and interleukin-6 (IL-6) via an Ang II dependent manner. bisphenol A 0-3 interleukin 6 Homo sapiens 108-112 30677511-10 2019 Consistently, BPA induced expression of TNFalpha and IL-6 was also attenuated by inhibitors of ERalpha and GPER. bisphenol A 14-17 interleukin 6 Homo sapiens 53-57 31019814-6 2019 To our knowledge, this is the first case report of IL6-producing pheochromocytoma along with autonomous cortisol production. Hydrocortisone 104-112 interleukin 6 Homo sapiens 51-54 31019654-8 2019 These novel findings showed that DHTS-induced ROS deregulated the Stat3/IL-6 pathway and induced CSC death. Reactive Oxygen Species 46-49 interleukin 6 Homo sapiens 72-76 30871567-12 2019 The levels of TNF-a, IL-6, and IL-8 were positively correlated with increases in BMI, serum glucose and cholesterol levels. Glucose 92-99 interleukin 6 Homo sapiens 21-25 30936876-3 2019 By using a novel protocol for the generation of mononuclear (M)-MDSC, we showed that PGE2 potentiates the GM-CSF/IL-6-dependent induction of CD33+CD11b+HLA-DR-CD14+ M-MDSC in vitro. Dinoprostone 85-89 interleukin 6 Homo sapiens 113-117 30936876-4 2019 PGE2 diminished the capacity of GM-CSF/IL-6 M-MDSC to produce proinflammatory cytokines upon activation and augmented their capacity to produce IL-27, IL-33, and TGF-beta. Dinoprostone 0-4 interleukin 6 Homo sapiens 39-43 30936876-5 2019 These results correlated with an increased potential of GM-CSF/IL-6/PGE2 M-MDSC to suppress T cell proliferation, expand alloreactive Th2 cells, and reduce the development of alloreactive Th17 and cytotoxic T cells. Dinoprostone 68-72 interleukin 6 Homo sapiens 63-67 30936876-6 2019 Interestingly, GM-CSF/IL-6/PGE2 M-MDSC displayed a lower capacity to induce TGF-beta-producing FoxP3+ regulatory Treg compared to GM-CSF/IL-6 M-MDSC, as a consequence of reduced IDO-1 expression. Dinoprostone 27-31 interleukin 6 Homo sapiens 22-26 30936876-8 2019 Cumulatively, PGE2 potentiated the suppressive phenotype and functions of GM-CSF/IL-6-induced M-MDSC and changed the mechanisms involved in Treg induction, which could be important for investigating new therapeutic strategies focused on MDSC-related effects in tumors and autoimmune diseases. Dinoprostone 14-18 interleukin 6 Homo sapiens 81-85 30690246-7 2019 The increase of IL-6 showed a statistically significant correlation with myristic acid, to a lesser extent with cis-9-eicosenoic acid and to the least extent with docosahexaenoic acid, inversely with pentadecanoic, gamma-linolenic and stearic acids. Gadoleic acid 112-133 interleukin 6 Homo sapiens 16-20 30887238-1 2019 A physiologically based pharmacokinetic (PBPK) model was used to simulate the impact of elevated levels of interleukin (IL)-6 on the exposure of several orally administered cytochrome P450 (CYP) probe substrates (caffeine, S-warfarin, omeprazole, dextromethorphan, midazolam, and simvastatin). Omeprazole 235-245 interleukin 6 Homo sapiens 107-125 30871567-12 2019 The levels of TNF-a, IL-6, and IL-8 were positively correlated with increases in BMI, serum glucose and cholesterol levels. Cholesterol 104-115 interleukin 6 Homo sapiens 21-25 30836628-7 2019 (3) Results: A one unit increase in neonatal WB-Iron was associated with a 38% decrease in mean interleukin (IL)-6 levels (0.62; 95% CI: 0.40-0.95, p = 0.03), and a 37% decrease in mean MBL levels (0.63; 95% CI: 0.41-0.95, p = 0.03), but was not statistically significant after correction for multiple testing. Iron 48-52 interleukin 6 Homo sapiens 96-114 30956980-4 2019 RT-qPCR data confirmed the accuracy of microarray data, and cytokines assay results indicated that 6 of the total 27 inflammatory cytokine secretions were significantly inhibited by myricetin pretreatment, including TNF-alpha, IFN-gamma, IL-1alpha, IL-1beta, IL-2, and IL-6. myricetin 182-191 interleukin 6 Homo sapiens 269-273 30866565-5 2019 Several fatty acids were associated with interferon-gamma (IFNgamma) and interleukins (ILs) IL-6, IL-8, and IL-10 at baseline and additionally also with IL-1b at 1 year. Fatty Acids 8-19 interleukin 6 Homo sapiens 92-96 30836628-8 2019 (4) Conclusions: In summary, we found that higher neonatal WB-iron content was inversely associated with IL-6 and MBL, which may increase susceptibility to infections. Iron 62-66 interleukin 6 Homo sapiens 105-109 30594784-6 2019 The addition of zafirlukast to culture media suppressed TNF-alpha-induced expression of endothelial vascular adhesion molecules, such as ICAM-1, VCAM-1, and induction of cytokines, including IL-1beta, IL-6, and IL-8. zafirlukast 16-27 interleukin 6 Homo sapiens 201-205 30508574-4 2019 N3 PUFAs (DHA 8.7 muM/EPA14.21 muM) or clozapine (3 muM) significantly reduced poly I:C-induced increase in iNOS, NFkB (p50/p65), IL-6 and nitrite when compared to non-treated cells. dehydroacetic acid 10-13 interleukin 6 Homo sapiens 130-134 30502626-0 2019 1,3,4-oxadiazole/chalcone hybrids: Design, synthesis, and inhibition of leukemia cell growth and EGFR, Src, IL-6 and STAT3 activities. 1,3,4-oxadiazole 0-16 interleukin 6 Homo sapiens 108-112 30502626-1 2019 A new series of 1,3,4-oxadiazole/chalcone hybrids was designed, synthesized, identified with different spectroscopic techniques and biologically evaluated as inhibitors of EGFR, Src, and IL-6. 1,3,4-oxadiazole 16-32 interleukin 6 Homo sapiens 187-191 30519866-7 2019 Our data show that dopamine treatment of human macrophages isolated from healthy and cART-treated donors promotes production of inflammatory mediators including IL-1beta, IL-6, IL-18, CCL2, CXCL8, CXCL9, and CXCL10. Dopamine 19-27 interleukin 6 Homo sapiens 171-175 30783430-0 2019 Ropivacaine at different concentrations on intrapartum fever, IL-6 and TNF-alpha in parturient with epidural labor analgesia. Ropivacaine 0-11 interleukin 6 Homo sapiens 62-66 30761568-9 2019 Levels of IL-6 and IL-8 were significantly lower in TG than CG at 3 months. Thioguanine 52-54 interleukin 6 Homo sapiens 10-14 30670152-4 2019 We found that endothelial IL-6 levels were significantly higher in response to cisplatin treatment, whereas levels of IL-6 upon cisplatin exposure remained unchanged in MDA-MB-231 breast cancer cells. Cisplatin 79-88 interleukin 6 Homo sapiens 26-30 30670152-4 2019 We found that endothelial IL-6 levels were significantly higher in response to cisplatin treatment, whereas levels of IL-6 upon cisplatin exposure remained unchanged in MDA-MB-231 breast cancer cells. Cisplatin 128-137 interleukin 6 Homo sapiens 118-122 30670152-5 2019 We additionally found an inverse correlation between IL-6 and miR-125a/let-7e expression levels in cisplatin treated ECs. Cisplatin 99-108 interleukin 6 Homo sapiens 53-57 30641086-13 2019 Furthermore, the inhibition of adenosine deaminase in endothelial cells in vitro attenuated LPS-mediated IL-6 release and soluble ICAM-1 and VCAM-1 concentration in the incubation medium through the restoration of the extracellular adenosine pool and adenosine receptor-dependent pathways. Adenosine 31-40 interleukin 6 Homo sapiens 105-109 30744811-4 2019 The results of ROS assay and ELISA indicated that PM2.5 (150 mug/ml) increased the level of cellular reactive oxygen species (ROS) and promoted the release of interleukin-6 (IL-6) in HBE cells. Reactive Oxygen Species 15-18 interleukin 6 Homo sapiens 174-178 30628691-10 2019 Furthermore, it was confirmed that metformin suppressed the LPS-induced secretion of TNF-alpha, IL-6, ICAM-1 and VCAM-1. Metformin 35-44 interleukin 6 Homo sapiens 96-100 30363006-1 2019 PURPOSE: The short-term restriction of carbohydrate (CHO) can potentially influence iron regulation via modification of postexercise interleukin-6 (IL-6) and hepcidin levels. Carbohydrates 39-51 interleukin 6 Homo sapiens 133-146 30363006-1 2019 PURPOSE: The short-term restriction of carbohydrate (CHO) can potentially influence iron regulation via modification of postexercise interleukin-6 (IL-6) and hepcidin levels. Carbohydrates 39-51 interleukin 6 Homo sapiens 148-152 30363006-1 2019 PURPOSE: The short-term restriction of carbohydrate (CHO) can potentially influence iron regulation via modification of postexercise interleukin-6 (IL-6) and hepcidin levels. Iron 84-88 interleukin 6 Homo sapiens 133-146 30363006-1 2019 PURPOSE: The short-term restriction of carbohydrate (CHO) can potentially influence iron regulation via modification of postexercise interleukin-6 (IL-6) and hepcidin levels. Iron 84-88 interleukin 6 Homo sapiens 148-152 30229691-9 2019 Values of interleukin-6 at the 90th percentile of its distribution were 8.31 pg/ml higher among those in DII quartile 4 compared with quartile 1 ( p = 0.02). dilC18(3) dye 105-108 interleukin 6 Homo sapiens 10-23 30859103-7 2019 Anti-inflammatory effect of alcohol-drinking in EtOH w/o LI can be presented by a reduced number of hepato-derived EVs, no upregulation of IL-6 and IL-33, and a miR "barcode" different from patients presenting with liver injury. Alcohols 28-35 interleukin 6 Homo sapiens 139-143 31170276-14 2019 Human calvarial osteoblasts secreted IL-6 only during the first 24 hours and only in the highest titanium concentration, whereas human gingival fibroblasts secreted IL-6 during the entire period. Titanium 97-105 interleukin 6 Homo sapiens 37-41 31170276-15 2019 The lowest titanium concentration showed stronger secretion of IL-6 compared to control. Titanium 11-19 interleukin 6 Homo sapiens 63-67 30867746-6 2019 Mechanistically, stimulation by IL-6 and TNF-alpha induced the trimethylation of histone H3 lysine 4 (H3K4Me3) at the MASTL promoter to facilitate chromatin accessibility. Lysine 92-98 interleukin 6 Homo sapiens 32-36 30867760-0 2019 Hyperbaric oxygen on rehabilitation of brain tumors after surgery and effects on TNF-alpha and IL-6 levels. Oxygen 11-17 interleukin 6 Homo sapiens 95-99 30941358-16 2019 In 7 patients that completed the treatment period, there was an association between elevated serum levels of IL-6, IL-1beta, TNF-alpha, CRP, and LPL and also the reduced serum levels of albumin, prealbumin, Zn, vitamin D, and GPS, respectively. Zinc 207-209 interleukin 6 Homo sapiens 109-113 30941358-16 2019 In 7 patients that completed the treatment period, there was an association between elevated serum levels of IL-6, IL-1beta, TNF-alpha, CRP, and LPL and also the reduced serum levels of albumin, prealbumin, Zn, vitamin D, and GPS, respectively. Vitamin D 211-220 interleukin 6 Homo sapiens 109-113 30859103-21 2019 Conclusions: Liver injury in alcohol-intoxicated TP is reflected by increased EV numbers, their specific miR barcode, and the correlated increase of systemic inflammatory markers IL-6 and IL-33. Alcohols 29-36 interleukin 6 Homo sapiens 179-183 30859103-16 2019 EVs, IL-6, and IL-33 levels were significantly increased in EtOH with LI vs. EtOH w/o LI group (p < 0.05). Ethanol 60-64 interleukin 6 Homo sapiens 5-9 30741955-7 2019 Supporting this result, glucose metabolism-related enzyme IRS1 and interleukin-6 (IL-6) were abnormally expressed, and levels of lysophosphatidylcholine (LysoPC) and its related enzyme phospholipase A2 (PLA2) were significantly altered in allogeneic groups compared to those in autologous groups. Glucose 24-31 interleukin 6 Homo sapiens 82-86 30838176-0 2019 Capsaicin Induces Apoptosis in KSHV-Positive Primary Effusion Lymphoma by Suppressing ERK and p38 MAPK Signaling and IL-6 Expression. Capsaicin 0-9 interleukin 6 Homo sapiens 117-121 30838176-5 2019 Here, we demonstrate that capsaicin markedly inhibited the growth of KSHV latently infected PEL cells by inhibiting ERK, p38 MAPK and expression hIL-6, which are known to contribute to PEL growth and survival. Capsaicin 26-35 interleukin 6 Homo sapiens 145-150 30838176-6 2019 The underlying mechanism of action by capsaicin was through the inhibition of ERK and p38 MAPK phosphorylation and signaling that affected hIL-6 expression. Capsaicin 38-47 interleukin 6 Homo sapiens 139-144 30863067-12 2019 Finally, we found PTX treatment suppressed the production of tumor necrosis factor alpah (TNF-alpha), interleukin 6 (IL-6) and transforming growth factor beta (TGF-beta) and inhibited the expression of alpha smooth muscle actin (alpha-SMA) and collagen I in HKFs. Paclitaxel 18-21 interleukin 6 Homo sapiens 102-115 30863067-12 2019 Finally, we found PTX treatment suppressed the production of tumor necrosis factor alpah (TNF-alpha), interleukin 6 (IL-6) and transforming growth factor beta (TGF-beta) and inhibited the expression of alpha smooth muscle actin (alpha-SMA) and collagen I in HKFs. Paclitaxel 18-21 interleukin 6 Homo sapiens 117-121 30520466-4 2019 First, N-acetyl-l-cysteine was used to decrease the viscosity of HSF samples and consequently enhance bacterial isolation with vancomycin-coated nano-magnetic beads. Acetylcysteine 7-26 interleukin 6 Homo sapiens 65-68 30318339-3 2019 Treatment of mice with metformin or exposure of murine or human alveolar macrophages to metformin prevented the particulate matter-induced generation of complex III mitochondrial reactive oxygen species, which were necessary for the opening of calcium release-activated channels (CRAC) and release of IL-6. Metformin 23-32 interleukin 6 Homo sapiens 301-305 30881912-8 2019 Results: T-correlation analysis showed that in both ropivacaine and bupivacaine groups, the TNF-alpha, IL-6, and IL-1 levels decreased after the block. Ropivacaine 52-63 interleukin 6 Homo sapiens 103-107 30318339-3 2019 Treatment of mice with metformin or exposure of murine or human alveolar macrophages to metformin prevented the particulate matter-induced generation of complex III mitochondrial reactive oxygen species, which were necessary for the opening of calcium release-activated channels (CRAC) and release of IL-6. Metformin 88-97 interleukin 6 Homo sapiens 301-305 30318339-3 2019 Treatment of mice with metformin or exposure of murine or human alveolar macrophages to metformin prevented the particulate matter-induced generation of complex III mitochondrial reactive oxygen species, which were necessary for the opening of calcium release-activated channels (CRAC) and release of IL-6. Reactive Oxygen Species 179-202 interleukin 6 Homo sapiens 301-305 30775257-7 2019 Post-HSCT patients with MPS II showed that IL-1beta and IL-6 were normalized as HS and DS levels decreased. Dermatan Sulfate 87-89 interleukin 6 Homo sapiens 56-60 30544062-10 2019 To establish the potent mechanism of action of alloxanthoxyletin derivatives 8, 9, 10 and 11 on HaCaT, A549 and HTB-140 cells, the level of IL-6 was measured. alloxanthoxyletin 47-64 interleukin 6 Homo sapiens 140-144 30414891-1 2019 Exchange protein activated by cyclic AMP (EPAC1) suppresses multiple inflammatory actions in vascular endothelial cells (VECs), partly due to its ability to induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene, the protein product of which inhibits interleukin 6 (IL6) signalling through the JAK/STAT3 pathway. Cyclic AMP 30-40 interleukin 6 Homo sapiens 270-283 30414891-1 2019 Exchange protein activated by cyclic AMP (EPAC1) suppresses multiple inflammatory actions in vascular endothelial cells (VECs), partly due to its ability to induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene, the protein product of which inhibits interleukin 6 (IL6) signalling through the JAK/STAT3 pathway. Cyclic AMP 30-40 interleukin 6 Homo sapiens 285-288 30863452-6 2019 Systematic analysis of the created TCMP-Compound-Target-Disease network revealed that DHI and NXT shared common targets such as PTGS2, F2, ADRB1, IL6, ALDH2, and CCL2, which were involved in the vasomotor system regulation, blood-brain barrier disruption, redox imbalance, neurotrophin activity, and brain inflammation. dehydrosoyasaponin I 86-89 interleukin 6 Homo sapiens 146-149 30192654-4 2019 Treatment of human adipose tissue with 10-1000 nM Dex decreased ATX secretion, increased LPP1 expression, and decreased mRNA expressions of IL-6, TNF-alpha, peroxisome proliferator-activated receptor (PPAR)-gamma, and adiponectin. Dexamethasone 50-53 interleukin 6 Homo sapiens 140-144 30638307-0 2019 The effect of isolated nocturnal oxygen desaturations on serum hs-CRP and IL-6 in patients with chronic obstructive pulmonary disease. Oxygen 33-39 interleukin 6 Homo sapiens 74-78 30638307-3 2019 OBJECTIVES: We aimed to evaluate if COPD patients who meet the Medicare guidelines for nocturnal oxygen therapy (iNOT+) had higher serum hs-CRP and IL-6 than those who did not meet the guidelines for iNOT (iNOT-). Oxygen 97-103 interleukin 6 Homo sapiens 148-152 30547263-6 2019 However, in the absence of LPS, IL-6 secretion was significantly increased in response to 2 microM of either cyanidin or chlorogenic acid (both p < 0.0001), as well as the combination treatment (p < 0.01). Chlorogenic Acid 121-137 interleukin 6 Homo sapiens 32-36 30721634-0 2019 Fluconazole induces genotoxicity in cultured human peripheral blood mononuclear cells via immunomodulation of TNF-alpha, IL-6, and IL-10: new challenges for safe therapeutic regimens. Fluconazole 0-11 interleukin 6 Homo sapiens 121-125 30721634-5 2019 Results: Our results demonstrated that FNZ induced cellular DNA damage and mutagenicity at concentrations above the plasma peak (>30 mug/mL) and 6 mug/mL, respectively, which was associated with increased TNF-alpha, and decrease IL-6 and IL-10 concentrations. Fluconazole 39-42 interleukin 6 Homo sapiens 229-233 30402990-9 2019 Overall, this meta-analysis suggests that taking curcumin-containing supplements may exert anti-inflammatory and antioxidant properties through a significant reduction in IL-6, hs-CRP, and MDA levels. Curcumin 49-57 interleukin 6 Homo sapiens 171-175 30553912-5 2019 In addition, we found that the mRNA expression of IL-1beta, IL-6, IL-8 and IL-17A were markedly down-regulated by treatment with betulinic acid in TNF-alpha-induced RA FLSs. betulinic acid 129-143 interleukin 6 Homo sapiens 60-64 29199785-1 2019 BACKGROUND: Muscle-derived interleukin-6 (IL-6) not only enhances glucose and fat metabolism but also has an anti-inflammatory effect that can prevent the development of cardiovascular disease (CVD) and metabolic syndrome. Glucose 66-73 interleukin 6 Homo sapiens 27-40 29199785-1 2019 BACKGROUND: Muscle-derived interleukin-6 (IL-6) not only enhances glucose and fat metabolism but also has an anti-inflammatory effect that can prevent the development of cardiovascular disease (CVD) and metabolic syndrome. Glucose 66-73 interleukin 6 Homo sapiens 42-46 30578970-0 2019 SIRT1 alleviates isoniazid-induced hepatocyte injury by reducing histone acetylation in the IL-6 promoter region. Isoniazid 17-26 interleukin 6 Homo sapiens 92-96 30578970-3 2019 We found that compared with the blank control group, expression of SIRT1 was decreased in the isoniazid group and that expression of NF-kappaB p65 was increased, leading to an increase of the expression of inflammatory cytokines Interleukin-6 (IL-6) and Tumour necrosis factor alpha (TNF-alpha). Isoniazid 94-103 interleukin 6 Homo sapiens 229-242 30578970-3 2019 We found that compared with the blank control group, expression of SIRT1 was decreased in the isoniazid group and that expression of NF-kappaB p65 was increased, leading to an increase of the expression of inflammatory cytokines Interleukin-6 (IL-6) and Tumour necrosis factor alpha (TNF-alpha). Isoniazid 94-103 interleukin 6 Homo sapiens 244-248 30569107-7 2019 The present data indicated that, compared with mannitol treatment, high glucose treatment reduced RPEC viability, increased TNF-alpha, IL-6 and IL-1beta secretion, increased ROS formation and promoted phosphorylation of AKT and mTOR. Glucose 72-79 interleukin 6 Homo sapiens 135-139 30273821-6 2019 RESULTS: At baseline, there was an effect of hours of sleep, alcohol intake, and physical activities (i.e., mean total metabolic equivalent of task hours per day [MET-hours/day]) on IL-6 levels. Alcohols 61-68 interleukin 6 Homo sapiens 182-186 30761069-5 2019 Results: In in vitro experiments, TRPV1 stimulation by capsaicin significantly reduced TNF and IL-6 release by activated microglial cells. Capsaicin 55-64 interleukin 6 Homo sapiens 95-99 30703123-8 2019 Despite all rapamycin-treated cells secreted significantly reduced levels of IL6, a major SASP cytokine, and expressed significantly higher levels of the pluripotency marker NANOG, the expression patterns of these markers were not correlated with the rapamycin-mediated increase in lifespan. Sirolimus 12-21 interleukin 6 Homo sapiens 77-80 30423400-12 2019 In the sepsis cohort CSF NT-proCNP levels correlated with CSF Interleukin-6 (IL-6) levels (r = 0.616, p < 0.05) and systemic inflammation represented by high plasma procalcitonin (PCT) levels at day 3 (r = 0.727, p < 0.05). NTproCNP 25-34 interleukin 6 Homo sapiens 62-75 30688289-8 2019 RESULTS Aristolochic acid inhibited HK-2 cell viability, induced cell apoptosis, increased the levels of ROS and inflammatory cytokines, including IL-1beta, IL-6, TNF-alpha, and activated the NF-kappaB pathway. aristolochic acid I 8-25 interleukin 6 Homo sapiens 157-161 30679569-4 2019 Furthermore, 5-FU increased RAGE and NFkappaB NLS immunostaining in enteric neurons, associated with a significant increase in the nitrite/nitrate, IL-6 and TNF-alpha levels, iNOS expression and MDA accumulation in the small intestine. Fluorouracil 13-17 interleukin 6 Homo sapiens 148-152 30423400-12 2019 In the sepsis cohort CSF NT-proCNP levels correlated with CSF Interleukin-6 (IL-6) levels (r = 0.616, p < 0.05) and systemic inflammation represented by high plasma procalcitonin (PCT) levels at day 3 (r = 0.727, p < 0.05). NTproCNP 25-34 interleukin 6 Homo sapiens 77-81 30647085-0 2019 CAF-Derived IL6 and GM-CSF Cooperate to Induce M2-like TAMs-Letter. Tamoxifen 55-59 interleukin 6 Homo sapiens 12-15 30718954-13 2019 The PSDT mediated by TOI_HNPs induced generation of intracellular ROS and downregulated the expression of HIF-1alpha and IL-6 in SKOV3 cells. ros 66-69 interleukin 6 Homo sapiens 121-125 30647086-0 2019 CAF-Derived IL6 and GM-CSF Cooperate to Induce M2-like TAMs-Response. Tamoxifen 55-59 interleukin 6 Homo sapiens 12-15 30056769-1 2019 Oncostain M, a member of the IL-6 family of cytokines, is produced by immune cells in response to infections and tissue injury. oncostain m 0-11 interleukin 6 Homo sapiens 29-33 30503721-4 2019 KEY FINDINGS: Data showed that doxorubicin + geopropolis diminished IL-6 secretion, stimulated TNF-alpha and IL-10 production, TLR-4 and CD80 expression, NF-kappaB and autophagy pathway, as well as the bactericidal activity. Doxorubicin 31-42 interleukin 6 Homo sapiens 68-72 30631031-0 2019 Atorvastatin Prevents Myocardial Fibrosis in Spontaneous Hypertension via Interleukin-6 (IL-6)/Signal Transducer and Activator of Transcription 3 (STAT3)/Endothelin-1 (ET-1) Pathway. Atorvastatin 0-12 interleukin 6 Homo sapiens 74-87 30631031-0 2019 Atorvastatin Prevents Myocardial Fibrosis in Spontaneous Hypertension via Interleukin-6 (IL-6)/Signal Transducer and Activator of Transcription 3 (STAT3)/Endothelin-1 (ET-1) Pathway. Atorvastatin 0-12 interleukin 6 Homo sapiens 89-93 30631031-6 2019 The IL-6/STAT3 pathway was observed to be suppressed by Ato, and ET-1 level in myocardial tissues was also downregulated by Ato. Atorvastatin 56-59 interleukin 6 Homo sapiens 4-8 30631031-6 2019 The IL-6/STAT3 pathway was observed to be suppressed by Ato, and ET-1 level in myocardial tissues was also downregulated by Ato. Atorvastatin 124-127 interleukin 6 Homo sapiens 4-8 30611297-10 2019 ROC curves showed that 66.7 pg/ml of IL-6, 20.85 pg/ml of IL-10 and 8.35 pg/ml of IFN-gamma had sensitivity and specificity for identifying KDSS as 85.2 and 62.8%; 66.7 and 83.7%; 74.1 and 74.4% respectively. kdss 140-144 interleukin 6 Homo sapiens 37-41 30384152-10 2019 Intriguingly, both resveratrol and JNK inhibitor SP600125 suppressed TNFalpha-induced IL6 and IL8 mRNA expression (P < 0.05). Resveratrol 19-30 interleukin 6 Homo sapiens 86-89 30520054-4 2019 Our results demonstrated that metformin significantly decreased the mRNA and protein levels of tumour necrosis factor-alpha (TNFalpha), interleukin (IL)-6, IL-8, and IL-1beta induced by TNFalpha. Metformin 30-39 interleukin 6 Homo sapiens 136-154 30713665-5 2018 As demonstrated by enzyme linked immunosorbent assay and 16S rDNA sequence analysis of stool samples, the consumption of hydrogen-rich water for two months significantly reduced serum malondialdehyde, interleukin-1, interleukin-6, tumour necrosis factor-alpha levels; then significantly increased serum superoxide dismutase, total antioxidant capacity levels and haemoglobin levels of whole blood. Hydrogen 121-129 interleukin 6 Homo sapiens 216-259 30713665-5 2018 As demonstrated by enzyme linked immunosorbent assay and 16S rDNA sequence analysis of stool samples, the consumption of hydrogen-rich water for two months significantly reduced serum malondialdehyde, interleukin-1, interleukin-6, tumour necrosis factor-alpha levels; then significantly increased serum superoxide dismutase, total antioxidant capacity levels and haemoglobin levels of whole blood. Water 135-140 interleukin 6 Homo sapiens 216-259 31468464-9 2019 Most importantly, the stimulatory effect of ibuprofen on production of inflammatory cytokines (TNF-alpha, IL-6) was inhibited by all tested bromamines. Ibuprofen 44-53 interleukin 6 Homo sapiens 106-110 30334082-10 2019 A novel association appeared for change in IL-6 in the metformin group (1.09 [1.021, 1.173]) and for baseline leptin in the lifestyle groups (1.31 [1.06, 1.63]). Metformin 55-64 interleukin 6 Homo sapiens 43-47 31061632-5 2019 Evidence that these IL-6-induced cytoplasmic and nuclear GFP-STAT3 bodies in live cells represented phase-separated condensates came from the observation that 1,6-hexanediol caused their disassembly within 30-60 seconds. hexamethylene glycol 159-173 interleukin 6 Homo sapiens 20-24 31345146-10 2019 RESULTS: Compared with control group, the folic acid plus vitamin B 12 group had significantly greater improvements in serum folate, homocysteine, vitamin B 12 and IL-6, TNF-alpha, MCP-1. Folic Acid 42-52 interleukin 6 Homo sapiens 164-168 30255760-6 2019 RESULTS: Results showed that in the NAC group, the serum levels of MDA, NO, IL-6, TNF-alpha, ESR and CRP were significantly lower than the baseline. Acetylcysteine 36-39 interleukin 6 Homo sapiens 76-80 28967799-7 2019 Interleukin (IL)-6 was increased by caffeinated coffee compared with placebo in one of four coffee trials, and by caffeine in three out of five studies. caffeinated coffee 36-54 interleukin 6 Homo sapiens 0-18 31965930-9 2019 RESULTS: A study of the cytotoxic activity of 6-ferrocenylpyrimidin-4(3H)-one derivatives by the MTT test has found that all compounds have a dose-dependent toxic effect on the lines of breast cancer cells (MCF-7) and normal human fibroblast cells (HSF). 6-ferrocenylpyrimidin-4(3h 46-72 interleukin 6 Homo sapiens 249-252 31405706-7 2019 CONCLUSIONS: It is suggested that daily consumption of resveratrol supplement may not change TNFalpha, TAC and CAL, but it would be beneficial in reducing serum levels of IL6. Resveratrol 55-66 interleukin 6 Homo sapiens 171-174 31519530-9 2019 This study found the model to predict the hepcidin level using IL-6 ferritin and the creatinine level as the hepcidin level (predicted)=-23.76+0.396 (IL 6)+0.448 (ferritin)+0.310 (creatinine). Creatinine 85-95 interleukin 6 Homo sapiens 150-154 31333000-0 2019 Melatonin Receptor 1beta Gene Polymorphism rs10830963, Serum Melatonin, TNF-alpha, IL-6, IL-1beta, in Egyptian Patients with Systemic Lupus Erythematosus. Melatonin 0-9 interleukin 6 Homo sapiens 83-87 31416412-0 2019 Atorvastatin Inhibited ROS Generation and Increased IL-1beta And IL-6 Release by Mononuclear Cells from Diabetic Patients. Atorvastatin 0-12 interleukin 6 Homo sapiens 65-69 30240585-5 2019 IL-6 trans-signaling activation caused a significant increase in STAT3 phosphorylation, expression of adhesion molecules, ROS production and apoptosis in HRECs whereas a significant decrease in mitochondrial membrane potential and NO production was observed in IL-6 trans-signaling activated cells. ros 122-125 interleukin 6 Homo sapiens 0-4 30641712-11 2019 CONCLUSIONS: It was found that vitamin D supplementation can be regarded as an effective way to prevent the progression of diabetic nephropathy by reducing levels of proteinuria, and inflammatory markers such as TNF-alpha and IL-6. Vitamin D 31-40 interleukin 6 Homo sapiens 226-230 31416412-11 2019 CONCLUSION: ATV inhibited ROS generation and activated IL-1 beta/IL-6 secretion in PBMNC of diabetes patients. Atorvastatin 12-15 interleukin 6 Homo sapiens 65-69 30445309-7 2019 Bilobalide also prevented the infiltration of CD4+ T cells, CD68+ macrophages and B220+ B cells within the brain, and reduced the inflammatory microenvironment mediated with Iba1+iNOS+ and Iba1+NF-kB+ microglia after CPZ challenge, accompanied by the inhibition of IL-1beta and IL-6 in the brain. bilobalide 0-10 interleukin 6 Homo sapiens 278-282 30156957-9 2019 WH elicits fast and robust pDC activation as evidenced by the release of interferon-alpha, TNF-alpha and IL-6. tryptophylhistidine 0-2 interleukin 6 Homo sapiens 105-109 30989958-2 2019 The objective of this study was to investigate the efficacy of cell penetrating peptide TAT-modified liposomes loaded with salvianolic acid B( SAB-TAT-LIP) on proliferation,migration and cell cycle of human skin fibroblasts( HSF),and preliminarily evaluate its effect on prevention and treatment of HS. salvianolic acid B 123-141 interleukin 6 Homo sapiens 225-228 30994016-7 2019 On the other hand, MRN-100 significantly induced the secretion of pro-inflammatory cytokines such as IL-6 only at high concentrations. mrn-100 19-26 interleukin 6 Homo sapiens 101-105 31146075-11 2019 In particular, 0.5 g of tungsten showed a significant rise of IL-6 which could also be found for IL-1beta and IL-8. Tungsten 24-32 interleukin 6 Homo sapiens 62-66 30959503-10 2019 Also, secretion of the studied solutes, with the exception of ICAM-1, was reduced in the presence of NAC: IL6 -34%, p < 0.01; VEGF -40%, p < 0.005; vWF -25%, p < 0.001; t-PA -47%, p < 0.01, and MMP9 -37%, p < 0.001. Acetylcysteine 101-104 interleukin 6 Homo sapiens 106-109 31408593-0 2019 [Study of the quantity of interleukin-6 by SDS-PAAG electrophoresis and immuno-enzyme analysis in mixed saliva after rinsing the oral cavity with oligonucleotide specific.] Sodium Dodecyl Sulfate 43-46 interleukin 6 Homo sapiens 26-39 31408593-0 2019 [Study of the quantity of interleukin-6 by SDS-PAAG electrophoresis and immuno-enzyme analysis in mixed saliva after rinsing the oral cavity with oligonucleotide specific.] Oligonucleotides 146-161 interleukin 6 Homo sapiens 26-39 31408593-1 2019 The selective properties of a solution of oligonucleotide specific to IL-6 on the concentration of IL-6 in mixed saliva of patients with oral inflammatory processes were studied using SDS-PAGE by electrophoresis and enzyme immunoassay. Oligonucleotides 42-57 interleukin 6 Homo sapiens 99-103 31408593-1 2019 The selective properties of a solution of oligonucleotide specific to IL-6 on the concentration of IL-6 in mixed saliva of patients with oral inflammatory processes were studied using SDS-PAGE by electrophoresis and enzyme immunoassay. Sodium Dodecyl Sulfate 184-187 interleukin 6 Homo sapiens 70-74 31408593-2 2019 The application of these methods showed that in the mixed saliva of patients after rinsing with a solution of an oligonucleotide specific for IL-6, the amount of IL-6 decreases. Oligonucleotides 113-128 interleukin 6 Homo sapiens 142-146 31408593-2 2019 The application of these methods showed that in the mixed saliva of patients after rinsing with a solution of an oligonucleotide specific for IL-6, the amount of IL-6 decreases. Oligonucleotides 113-128 interleukin 6 Homo sapiens 162-166 31408593-3 2019 The ELISA Kit and 20% SDS-PAGE showed the highest sensitivity to determine the concentration of IL-6 in saliva, which should be considered in clinical laboratory practice. Sodium Dodecyl Sulfate 22-25 interleukin 6 Homo sapiens 96-100 30402883-8 2019 Therefore, it appears that perturbation in iron homoeostasis has essential role in HLA-DR mediated antigen presentation and innate armoury by downregulating iNOS as well as altering IFN-gamma, IL-6 and IL-10 profiles. Iron 43-47 interleukin 6 Homo sapiens 193-197 32105004-12 2019 Vitamin D reduced interleukin-6 levels by its antiinflammatory effect. Vitamin D 0-9 interleukin 6 Homo sapiens 18-31 30598040-6 2018 DHS diminished interleukin-6 (IL-6) and interleukin-8 (IL-8) secretion but induced the significant upregulation of IL-8 mRNA associated with NF-kappaB and AP-1 activation. Silybin 0-3 interleukin 6 Homo sapiens 15-28 30598040-6 2018 DHS diminished interleukin-6 (IL-6) and interleukin-8 (IL-8) secretion but induced the significant upregulation of IL-8 mRNA associated with NF-kappaB and AP-1 activation. Silybin 0-3 interleukin 6 Homo sapiens 30-34 30587227-13 2018 Anti-IL-6 blockade therapy with tocilizumab resulted in excellent clinical response, allowing the total resolution of the immune-related adverse events (irAEs) and leading to successful steroid tapering. Steroids 186-193 interleukin 6 Homo sapiens 5-9 30369518-15 2018 And we found that 786-O RCC cells secrete high IL-6 levels after low dose stimulation with the TKIs sorafenib, sunitinib and pazopanib, inducing activation of AKT-mTOR pathway, NFkappaB, HIF-2alpha and VEGF expression. pazopanib 125-134 interleukin 6 Homo sapiens 47-51 30571738-8 2018 Finally, anti-Sm mAb still up-regulated the IL-6 production of monocytes in the presence of anti-RNP mAb under the influence of N-acetyl cysteine or pyrrolidine dithiocarbamate that totally abrogated the IL-6 production provoked by anti-Sm mAb alone in the absence of anti-RNP mAb. Acetylcysteine 128-145 interleukin 6 Homo sapiens 44-48 30571738-8 2018 Finally, anti-Sm mAb still up-regulated the IL-6 production of monocytes in the presence of anti-RNP mAb under the influence of N-acetyl cysteine or pyrrolidine dithiocarbamate that totally abrogated the IL-6 production provoked by anti-Sm mAb alone in the absence of anti-RNP mAb. Acetylcysteine 128-145 interleukin 6 Homo sapiens 204-208 30899874-9 2019 The association between IL-6 and hemoglobin in children with CKD remained significant after adjustment for CKD stage, iron therapy, and hepcidin. Iron 118-122 interleukin 6 Homo sapiens 24-28 30545407-10 2018 HIF1A-AS2 and IL6 improved the expression level of osteoblast markers Runx2, Osterix, and Osteocalcin and also accelerated the formation of calcium nodule and ALP activity, yet miR-665 had opposite effects. Calcium 140-147 interleukin 6 Homo sapiens 14-17 28899203-6 2018 In addition to the well-established ROS-dependent pathway, recent studies have provided evidence of the direct repression of the transcription of pro-inflammatory cytokine genes, such as IL1b and IL6 (encoding Interleukin-1beta and Interleukin-6, respectively). Reactive Oxygen Species 36-39 interleukin 6 Homo sapiens 196-199 28899203-6 2018 In addition to the well-established ROS-dependent pathway, recent studies have provided evidence of the direct repression of the transcription of pro-inflammatory cytokine genes, such as IL1b and IL6 (encoding Interleukin-1beta and Interleukin-6, respectively). Reactive Oxygen Species 36-39 interleukin 6 Homo sapiens 232-245 30583668-3 2018 Materials and methods: Tetra-ARMS PCR was employed to analyze the polymorphism status of theASIC1 and IL-6 genes with 85 paraffin-embedded tissue blocks from cases and 117 normal blood samples as controls.We also investigated mRNA expression levels of these genes in 12 cases and controls using real-time PCR. Paraffin 121-129 interleukin 6 Homo sapiens 102-106 30572654-3 2018 We found that Ponatinib inhibits STAT3 activity driven by EGF/EGFR, IL-6/IL-6R and IL-11/IL-11R, three major ligand/receptor systems involved in CRC development and progression. ponatinib 14-23 interleukin 6 Homo sapiens 68-72 30574167-9 2018 Results: FP and MP-AzeFlu (all dilutions) and AZE (1:102) significantly reduced IL-6 secretion and eosinophil survival compared with positive controls. azelastine 46-49 interleukin 6 Homo sapiens 80-84 30029111-9 2018 This enhanced ROS inflicted severe inflammation and subsequent fibrosis, evident from increased pro-inflammatory-cum-fibrogenic cytokines generation (IL-1beta, IL-2, IL-6, TNF-alpha and TGF-beta). ros 14-17 interleukin 6 Homo sapiens 166-170 30518684-3 2018 Inflammatory cytokine IL-6 is elevated in residual tumors after platinum treatment, and we hypothesized that IL-6 plays a critical role in platinum-induced OCSC enrichment. Platinum 139-147 interleukin 6 Homo sapiens 109-113 30518684-5 2018 We show that platinum induces IL-6 secretion by cancer-associated fibroblasts in the tumor microenvironment, promoting OCSC enrichment in residual tumors after chemotherapy. Platinum 13-21 interleukin 6 Homo sapiens 30-34 30518684-0 2018 IL-6 mediates platinum-induced enrichment of ovarian cancer stem cells. Platinum 14-22 interleukin 6 Homo sapiens 0-4 30518684-9 2018 We conclude that IL-6 signaling blockade combined with an HMA can eliminate OCSC after platinum treatment, supporting this strategy to prevent tumor recurrence after standard chemotherapy. Platinum 87-95 interleukin 6 Homo sapiens 17-21 30518684-3 2018 Inflammatory cytokine IL-6 is elevated in residual tumors after platinum treatment, and we hypothesized that IL-6 plays a critical role in platinum-induced OCSC enrichment. Platinum 64-72 interleukin 6 Homo sapiens 22-26 29364751-6 2018 Furthermore, HG could promote the generation of reactive oxygen species (ROS), while N-acetyl cysteine, a ROS scavenger, had an inhibitory effect on the expression of TNF-alpha, IL-6 and PAI-1 in HG-treated cells. Acetylcysteine 85-102 interleukin 6 Homo sapiens 178-182 29790294-10 2018 Tofacitinib inhibited the effect of oncostatin M (OSM) on interleukin-6 (IL-6) and monocyte chemotactic protein 1 and reversed the effects of OSM on RASF cellular metabolism. tofacitinib 0-11 interleukin 6 Homo sapiens 58-71 29790294-10 2018 Tofacitinib inhibited the effect of oncostatin M (OSM) on interleukin-6 (IL-6) and monocyte chemotactic protein 1 and reversed the effects of OSM on RASF cellular metabolism. tofacitinib 0-11 interleukin 6 Homo sapiens 73-77 30563042-4 2018 H2O2 at low concentrations can trigger a transient anti-inflammatory adiponectin secretion and reduced gene expression of toll-like receptors (TLRs) in PBMCs but may act as a stimulator of proinflammatory genes (IL6, IL8) and mitochondrial dynamics-related proteins (Mtf2, NRF2, Tfam). Hydrogen Peroxide 0-4 interleukin 6 Homo sapiens 212-215 29235373-8 2018 IL-6 was significantly associated with glycerol in all models (p < .05), with glycerol levels increasing by 106% in individuals with AGM after AP (p <.05) compared to a 30.3% increase in individuals with normal glucose metabolism (NGM) (p >.05). Glucose 217-224 interleukin 6 Homo sapiens 0-4 30134219-15 2018 Both curcumin-loaded liposomes formulation (1 mug/mL, 5 mug/mL) resulted in significant (p < 0.05) reduction in the level of pro-inflammatory marker expression such as IL-6, IL-8, IL-1beta and TNF-a compared to positive control group. Curcumin 5-13 interleukin 6 Homo sapiens 171-175 30501618-9 2018 CONCLUSIONS: The administration of 10 mg dexamethasone 1 h before the surgery, and repeated at 6 h postoperatively can significantly reduce the level of postoperative CRP and IL-6 and the incidence of PONV, relieve pain, achieve an additional analgesic effect, and improve the early ROM compared with the other two groups in TKA. Dexamethasone 41-54 interleukin 6 Homo sapiens 175-179 30538945-9 2018 In addition, 17-beta estradiol and progesterone suppressed the production of IL-6 in the presence and absence of poly(I:C). Estradiol 13-30 interleukin 6 Homo sapiens 77-81 30538945-9 2018 In addition, 17-beta estradiol and progesterone suppressed the production of IL-6 in the presence and absence of poly(I:C). Progesterone 35-47 interleukin 6 Homo sapiens 77-81 29098425-9 2018 On the other hand, following the intervention with the unSFA-fiber-enriched breakfast, postprandial IL-6 expression showed a reduction tendency comparing to the pre-intervention value (p = 0.08). Dietary Fiber 61-66 interleukin 6 Homo sapiens 100-104 30340925-12 2018 Moreover, TNF-alpha, IL-1 and IL-6 can induce the production of other cytokines, matrix metalloproteinases (MMPs) and prostaglandins and inhibit the synthesis of proteoglycans and type II collagen; thus, they play a pivotal role in cartilage matrix degradation and bone resorption in OA. Prostaglandins 118-132 interleukin 6 Homo sapiens 30-34 30420132-13 2018 Exposure to ascorbate- or glutathione-related OP was significantly associated with increased inflammatory and neural biomarkers including interleukin-6, VEGF, UCHL1, and S100 calcium-binding protein B in blood, and malondialdehyde and 8-hydroxy-deoxy-guanosine in urine. Glutathione 26-37 interleukin 6 Homo sapiens 138-151 30733764-8 2018 Kolaviron and selenium also reduced hydrogen peroxide-induced secretion of nitric oxide, TNF-alpha, IL-1 and IL-6 by transformed U937 cells. kolaviron 0-9 interleukin 6 Homo sapiens 109-113 30111198-7 2018 Several studies have shown intriguing pharmacologic effects associated with curcumin, which inhibits NF-kappaB expression by regulating NF-kappaB/IkB pathway and down-regulation expression of pro-inflammatory cytokines, such as Interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha. Curcumin 76-84 interleukin 6 Homo sapiens 248-252 30713180-1 2018 AIM: Evaluation of the effect of glucosamine-chondroitin combination, tramadol, and sodium hyaluronic acid in temporomandibular joint (TMJ) disorders and its impact on the expression of various cytokines such as IL-6, IL-1beta, TNF-alpha, and PGE2. Dinoprostone 243-247 interleukin 6 Homo sapiens 212-216 30733764-8 2018 Kolaviron and selenium also reduced hydrogen peroxide-induced secretion of nitric oxide, TNF-alpha, IL-1 and IL-6 by transformed U937 cells. Hydrogen Peroxide 36-53 interleukin 6 Homo sapiens 109-113 30257125-1 2018 Exposures to occupationally relevant ultrafine, zinc- and copper-containing welding fumes cause inflammatory responses involving systemic IL-6, C-reactive protein (CRP) and serum amyloid A (SAA), all associated with elevated risk of cardiovascular events. Copper 58-64 interleukin 6 Homo sapiens 138-142 30251185-5 2018 By treatment with inflammatory cytokines IL-1beta, TNFalpha or TGF-beta after treatment with or without the NF-kappaB inhibitor curcumin, curucumin blocked the production and secretion of IL-6 upregulated by IL-1beta, TNFalpha, or TNFalpha/TGF-beta in all fibroblasts. Curcumin 128-136 interleukin 6 Homo sapiens 188-192 30532634-14 2018 We also confirmed that zingerone suppressed the level of redox sensitive transcription factor NFkappaB and downregulated other downstream inflammatory cytokines like interleukins (IL1-beta IL-2, IL-6) and tumor necrosis factor alpha (TNF-alpha). zingerone 23-32 interleukin 6 Homo sapiens 195-199 30291953-6 2018 Meanwhile, tyrosol attenuated the released TNF-alpha and IL-6 level from astrocyte via regulating Janus N-terminal kinase (JNK). 4-hydroxyphenylethanol 11-18 interleukin 6 Homo sapiens 57-61 30244119-9 2018 Finally, capsaicin (<=125 muM) significantly increased lipopolysaccharide-stimulated IL-6 and TNF-alpha release from THP-1 cells, whereas phytohaemagglutinin-stimulated IL-1beta, TNF-alpha, MCP-1 and IL-6 release were concentration-dependently inhibited by capsaicin. Capsaicin 9-18 interleukin 6 Homo sapiens 88-92 30244119-9 2018 Finally, capsaicin (<=125 muM) significantly increased lipopolysaccharide-stimulated IL-6 and TNF-alpha release from THP-1 cells, whereas phytohaemagglutinin-stimulated IL-1beta, TNF-alpha, MCP-1 and IL-6 release were concentration-dependently inhibited by capsaicin. Capsaicin 9-18 interleukin 6 Homo sapiens 203-207 30458886-9 2018 IGF-1R inhibition in tumor epithelial cells elevated interleukin (IL)-6 and C-C motif chemokine ligand 2 (CCL2) expression, which was reversed by ROS scavenging. Reactive Oxygen Species 146-149 interleukin 6 Homo sapiens 53-71 30595799-0 2018 Tryptophan Photoproduct FICZ Upregulates IL1A, IL1B, and IL6 Expression via Oxidative Stress in Keratinocytes. Tryptophan 0-10 interleukin 6 Homo sapiens 57-60 30595799-5 2018 FICZ also upregulated the expression of IL1A and IL1B, as well as the expression of IL6 and the production of its protein product, in an AHR- and ROS-dependent fashion. Reactive Oxygen Species 146-149 interleukin 6 Homo sapiens 84-87 30400326-4 2018 Exposing monocytes to CaP-CHI-HA resulted in a secretion of pro-healing VEGF and TGF-beta growth factors, TNF-alpha, MCP-1, IL-6 and IL-8 pro-inflammatory mediators but also IL-10 anti-inflammatory cytokine along with an inflammatory index below 1.5 (versus 2.5 and 7.5 following CaP and LPS stimulation, respectively). cap 22-25 interleukin 6 Homo sapiens 124-128 30442152-12 2018 Compared to mock-infected cells, VZV-infected qHA-sps showed significantly reduced secretion of IL-2, IL-4, IL-6, IL-12p70, and IL-13, while VZV-infected qHA-hps showed significantly reduced IL-8 secretion. qha-sps 46-53 interleukin 6 Homo sapiens 108-112 30463189-3 2018 The results showed that COS pretreatment for 12 h significantly ameliorated lipid accumulation in HepG2 cells exposed to PA for 24 h, accompanied by a reversing of the upregulated mRNA expression of proinflammatory cytokines (IL-6, MCP-1, TNF-alpha) and glucolipid metabolism-related regulators (SCD-1, ACC1, PCK1-alpha). carbonyl sulfide 24-27 interleukin 6 Homo sapiens 226-230 30390648-6 2018 RESULTS: Challenge with the omega-6 PUFA arachidonic acid (AA), but not omega-3 PUFAs or SFAs, resulted in increased IL-6 and CXCL8 release from fibroblasts, however IL-6 and CXCL8 release was reduced in COPD (n = 19) compared to non-COPD (n = 36). Arachidonic Acid 41-57 interleukin 6 Homo sapiens 117-121 30390648-6 2018 RESULTS: Challenge with the omega-6 PUFA arachidonic acid (AA), but not omega-3 PUFAs or SFAs, resulted in increased IL-6 and CXCL8 release from fibroblasts, however IL-6 and CXCL8 release was reduced in COPD (n = 19) compared to non-COPD (n = 36). Arachidonic Acid 41-57 interleukin 6 Homo sapiens 166-170 30016150-6 2018 Ethanol modestly increased IL-6 secretion in C2C12 myotubes. Ethanol 0-7 interleukin 6 Homo sapiens 27-31 30390336-12 2018 IL-6 treatment induced the phosphorylation of Stat3 and Bmi-1 expression, increased cell viability, as well as elevated glucose consumption, lactate production, and HK2 expression; however, the effects of IL-6 were attenuated by icaritin or S3I-201 treatment. Glucose 120-127 interleukin 6 Homo sapiens 0-4 30390336-12 2018 IL-6 treatment induced the phosphorylation of Stat3 and Bmi-1 expression, increased cell viability, as well as elevated glucose consumption, lactate production, and HK2 expression; however, the effects of IL-6 were attenuated by icaritin or S3I-201 treatment. Lactic Acid 141-148 interleukin 6 Homo sapiens 0-4 30390336-12 2018 IL-6 treatment induced the phosphorylation of Stat3 and Bmi-1 expression, increased cell viability, as well as elevated glucose consumption, lactate production, and HK2 expression; however, the effects of IL-6 were attenuated by icaritin or S3I-201 treatment. Lactic Acid 141-148 interleukin 6 Homo sapiens 205-209 29939445-14 2018 Ruxolitinib also significantly inhibited the production of IL-6, TNF-alpha and MCP-1 as induced by A23817 and substance P. Selective STAT5 inhibition with pimozide resulted in diminished degranulation and inhibition of cytokine production as induced by A23817 and substance P. CONCLUSIONS & CLINICAL RELEVANCE: This study demonstrates that the JAK1/JAK2 inhibitor ruxolitinib can inhibit MCactivity, possibly through prevention of STAT5 activation. Pimozide 155-163 interleukin 6 Homo sapiens 59-63 30446246-3 2018 AIM OF STUDY: To determine if a loading dose of 80 mg of atorvastatin before primary angioplasty reduces the frequency of no reflow, hs-CRP, IL6 intracoronary levels, and major combined cardiovascular events at 30 d. METHODS: In this controlled clinical trial, we randomly assigned 103 adult patients within the 12 h of acute ST-elevation myocardial infarction (STEMI) to receive 80 mg of atorvastatin additional to standard treatment (AST) before performing primary PCI versus standard treatment (ST) alone. Atorvastatin 57-69 interleukin 6 Homo sapiens 141-144 30547064-1 2018 The data set presented here is associated with the article "Intracellular calcium and NF-kB regulate hypoxia-induced leptin, VEGF, IL-6 and adiponectin secretion in human adipocytes" (Al-Anazi et al., 2018). Calcium 74-81 interleukin 6 Homo sapiens 131-135 30025340-7 2018 In this study, switching from HSF (1.12% S) to LSF (0.38% S) reduced emitted PM by 12%, OC by 20%, sulfate by 71%, and particulate PAHs by 94%, but caused an increase in single-ring aromatics. 2-n-octyl-4-isothiazolin-3-one 88-90 interleukin 6 Homo sapiens 30-33 30025340-7 2018 In this study, switching from HSF (1.12% S) to LSF (0.38% S) reduced emitted PM by 12%, OC by 20%, sulfate by 71%, and particulate PAHs by 94%, but caused an increase in single-ring aromatics. Sulfates 99-106 interleukin 6 Homo sapiens 30-33 30226556-9 2018 The in vitro experiments demonstrated that NGE reduced the phorbol 12-myristate 13-acetate + ionomycin-induced expression of pro-inflammatory cytokines interleukin (IL)-4, IL-13, tumor necrosis factor-alpha, and IL-6 in HMC-1 cells. Ionomycin 93-102 interleukin 6 Homo sapiens 212-216 30051214-12 2018 The serum IL-6 level was associated with N-demethylation activity and tramadol tolerability. Nitrogen 41-42 interleukin 6 Homo sapiens 10-14 30091210-8 2018 Melatonin treatment reversed the H/R effect, restoring IL-10, TNF, and IL-6 levels to those of the normoxia condition. Melatonin 0-9 interleukin 6 Homo sapiens 71-75 30226556-9 2018 The in vitro experiments demonstrated that NGE reduced the phorbol 12-myristate 13-acetate + ionomycin-induced expression of pro-inflammatory cytokines interleukin (IL)-4, IL-13, tumor necrosis factor-alpha, and IL-6 in HMC-1 cells. Tetradecanoylphorbol Acetate 59-90 interleukin 6 Homo sapiens 212-216 30383519-5 2018 High glucose (HG) significantly increased expression of IL-6, intercellular adhesion molecule (ICAM-1), matrix metalloproteinase-2 & 9, and migration of vascular smooth muscle cells. Glucose 5-12 interleukin 6 Homo sapiens 56-60 30261465-6 2018 Levels of IL-1beta-induced inflammatory biomarkers including TNF-alpha, COX-2, IL-6 and iNOS were reduced by Co-Q10, which was possibly associated with inhibition of NF-kappaB signaling activation. coenzyme Q10 109-115 interleukin 6 Homo sapiens 79-83 30098076-10 2018 Compared with the oral placebo treatment, melatonin decreased the expression of NF-kappaB, tumor necrosis factor-alpha, interleukin-6 (IL-6), and S100beta (P < 0.05) and increased the expression of Nrf2, SOD, CAT, and GPx (P < 0.05) in patients after CEA. Melatonin 42-51 interleukin 6 Homo sapiens 120-133 30098076-10 2018 Compared with the oral placebo treatment, melatonin decreased the expression of NF-kappaB, tumor necrosis factor-alpha, interleukin-6 (IL-6), and S100beta (P < 0.05) and increased the expression of Nrf2, SOD, CAT, and GPx (P < 0.05) in patients after CEA. Melatonin 42-51 interleukin 6 Homo sapiens 135-139 29964299-0 2018 Catechol derived from aronia juice through lactic acid bacteria fermentation inhibits breast cancer stem cell formation via modulation Stat3/IL-6 signaling pathway. Lactic Acid 43-54 interleukin 6 Homo sapiens 141-145 30308181-0 2018 Intracellular calcium and NF-kB regulate hypoxia-induced leptin, VEGF, IL-6 and adiponectin secretion in human adipocytes. Calcium 14-21 interleukin 6 Homo sapiens 71-75 30344742-0 2018 Doxorubicin resistance induces IL6 activation in the colon cancer cell line LS180. Doxorubicin 0-11 interleukin 6 Homo sapiens 31-34 29991802-9 2018 Consistent with these findings, we demonstrated a significant induction in mRNA expression levels of STAT3 target genes (IL-6, IL-17A, BCL-xL, Survivin, and c-MYC) in BE and EAC cells, following acidic bile salts treatment. Bile Acids and Salts 202-212 interleukin 6 Homo sapiens 121-125 30344742-9 2018 In conclusion, in the present study it was demonstrated that doxorubicin resistance led to activation of IL6 signalling pathway which was further elevated by the knockdown of PTEN in the colon cancer cell line LS180. Doxorubicin 61-72 interleukin 6 Homo sapiens 105-108 30344742-10 2018 Thus, inhibiting the IL6 loop may provide an alternative pathway to tackle doxorubicin resistance. Doxorubicin 75-86 interleukin 6 Homo sapiens 21-24 30510589-0 2018 Oxygen Tension Strongly Influences Metabolic Parameters and the Release of Interleukin-6 of Human Amniotic Mesenchymal Stromal Cells In Vitro. Oxygen 0-6 interleukin 6 Homo sapiens 75-88 29772587-7 2018 In cells pretreated with rapamycin, the inhibitory effects of cardamonin were completely suppressed with regards to the phosphorylation of the mammalian target of rapamycin, ribosomal protein S6 kinase 1, TNF-alpha, and interleukin-6, and nuclear factor-kappaB p65 protein expression was decreased. Sirolimus 25-34 interleukin 6 Homo sapiens 220-233 31158931-12 2018 A weak positive correlation was found between COHb and lactate levels in patients (P=0.013; r=0.390).This study shows that IL-6 level increases in CO-poisoned patients, but it is not correlated with the severity of the intoxication. Lactic Acid 55-62 interleukin 6 Homo sapiens 123-127 30510589-8 2018 Furthermore, IL-6 was significantly increased at 20% oxygen. Oxygen 53-59 interleukin 6 Homo sapiens 13-17 30510589-9 2018 To conclude, short-time cultivation at 20% oxygen of freshly isolated hAMSCs induced significant changes in mitochondrial function and release of IL-6. Oxygen 43-49 interleukin 6 Homo sapiens 146-150 30241947-9 2018 We demonstrated that physiological temperature (37 C) and O2 supply were essential for the induction of IL-6 release from the incubated muscle, suggesting it is a controlled secretion rather than a spontaneous leak. Oxygen 59-61 interleukin 6 Homo sapiens 105-109 30386182-9 2018 After stimulation of MonoMac6 with LPS for 24 h, ZNF580 negatively correlated with the amount of secreted IL-6. monomac6 21-29 interleukin 6 Homo sapiens 106-110 30369866-7 2018 IL-6 and TNF-alpha can activate the NFkappaB pathway, increasing production of reactive oxygen species that can cause DNA damage. Reactive Oxygen Species 79-102 interleukin 6 Homo sapiens 0-4 30600293-7 2018 The haplotype GA of IL-6 at -174 and nt565, was significantly overrepresented in the AIH group, compared to (20.9% of AIH vs. 1.4% in controls p &lt; 0.0001). Adenosine Monophosphate 146-149 interleukin 6 Homo sapiens 20-24 30308017-9 2018 EPFR increased IL-6 release in an ROS and AhR- and oxidant-dependent manner. Reactive Oxygen Species 34-37 interleukin 6 Homo sapiens 15-19 30308035-0 2018 Anti-metastatic effect of metformin via repression of interleukin 6-induced epithelial-mesenchymal transition in human colon cancer cells. Metformin 26-35 interleukin 6 Homo sapiens 54-67 30308035-7 2018 Furthermore, pathway analysis revealed that the metformin-predicted group was characterized by decreased interleukin (IL)-6 pathway signaling, epithelial-mesenchymal transition, and colon cancer metastatic signaling. Metformin 48-57 interleukin 6 Homo sapiens 105-123 30308035-10 2018 These findings suggest that blockade of IL-6-induced epithelial-mesenchymal transition is an antitumor mechanism of metformin. Metformin 116-125 interleukin 6 Homo sapiens 40-44 29894789-4 2018 While TNF-alpha, IL-6, IL-1beta, and NF-kappaB mRNA and protein expression were higher in control HOb-OA cells, the combined supplementation with allopurinol and l-arginine substantially reduced their expression in HOb-OA cells by >40%. Arginine 162-172 interleukin 6 Homo sapiens 17-21 30402509-4 2018 ethanol extract (KIOM-2015E) on the expression of tight junction proteins and the levels of inflammation in the cell model induced with interleukin-6- (IL-6-) and mouse model of dextran sodium sulfate (DSS) induced with acute colitis. Ethanol 0-7 interleukin 6 Homo sapiens 152-156 30022772-0 2018 TRPV4 Channel-Regulated ATP Release Contributes to gamma-Irradiation-Induced Production of IL-6 and IL-8 in Epidermal Keratinocytes. Adenosine Triphosphate 24-27 interleukin 6 Homo sapiens 91-95 30333797-9 2018 CPA patients did not differ significantly in the BALF cytokine profile compared to patients with respiratory disorders without CPA, but showed significant higher values for IFN-gamma, IL-1b, IL-6, IL-8, and TNF-alpha compared to healthy individuals. cpa 0-3 interleukin 6 Homo sapiens 191-195 29590534-11 2018 IL-6 correlated with active ghrelin (r = 0.37; p = 0.036) and cortisol (r = 0.26; p = 0.049). Ghrelin 28-35 interleukin 6 Homo sapiens 0-4 30022772-9 2018 Our results suggest that gamma-irradiation of keratinocytes induces ATP release via activation of the TRPV4 channel, and then ATP activates P2Y11 receptor and p38 MAPK-NF-kappaB signaling, resulting in IL-6/IL-8 production. Adenosine Triphosphate 126-129 interleukin 6 Homo sapiens 202-206 30022772-5 2018 HaCaT cells treated with TRPV4 channel agonist GSK1016790A also showed increased IL-6 and IL-8 production. N-(1-((4-(2-(((2,4-dichlorophenyl)sulfonyl)amino)-3-hydroxypropanoyl)-1-piperazinyl)carbonyl)-3-methylbutyl)-1-benzothiophene-2-carboxamide 47-58 interleukin 6 Homo sapiens 81-85 30022772-6 2018 In both cases, IL-6/IL-8 production was not increased at 24 h after stimulation, but was increased at 48 h. ATP was released from cells exposed to gamma-irradiation or TRPV4 channel agonist, and the release was suppressed by TRPV4 channel inhibitors. Adenosine Triphosphate 108-111 interleukin 6 Homo sapiens 15-19 29933233-5 2018 The macrophages cultured on Cu-containing MAO-fabricated surfaces were polarized to M1 phenotype, evidenced by the high expression levels of inducible nitric oxide synthase (iNOS), low expression levels of arginase1 (Arg1), enhanced pro-inflammatory cytokine interleukin-6 (IL-6) release and inhibited IL-4 and IL-10 (anti-inflammatory cytokines) release. Copper 28-30 interleukin 6 Homo sapiens 259-272 30402489-5 2018 LDL-cholesterol levels (i) positively correlated with IL-6, IFN-gamma, E-selectin, sCD-40L, 8-OH-2"-deoxyguanosine, platelet aggregation to ADP, collagen, AA, and aspirin IC-50 and (ii) negatively correlated with IL-10 and sRAGE. Cholesterol 4-15 interleukin 6 Homo sapiens 54-58 29933233-5 2018 The macrophages cultured on Cu-containing MAO-fabricated surfaces were polarized to M1 phenotype, evidenced by the high expression levels of inducible nitric oxide synthase (iNOS), low expression levels of arginase1 (Arg1), enhanced pro-inflammatory cytokine interleukin-6 (IL-6) release and inhibited IL-4 and IL-10 (anti-inflammatory cytokines) release. Copper 28-30 interleukin 6 Homo sapiens 274-278 30516500-3 2018 In patients with CHC, the genotype CC of the polymorphism of the IL-6 gene was associated with fluctuations in the concentration of IL-6 in the blood within the reference range, which was prognostically favorable for the formation of SVR 24 for AVT according to the peg-IFNalpha + SOF + RBV. Polyethylene Glycols 266-269 interleukin 6 Homo sapiens 65-69 30516500-3 2018 In patients with CHC, the genotype CC of the polymorphism of the IL-6 gene was associated with fluctuations in the concentration of IL-6 in the blood within the reference range, which was prognostically favorable for the formation of SVR 24 for AVT according to the peg-IFNalpha + SOF + RBV. Polyethylene Glycols 266-269 interleukin 6 Homo sapiens 132-136 30076857-7 2018 Treatment with the active form of vitamin D inhibited palmitate-induced TNF-alpha and IL-6 production in macrophages. Vitamin D 34-43 interleukin 6 Homo sapiens 86-90 29951874-5 2018 In the present study, we showed that hydrogen peroxide (H2O2) remarkably enhances the expression and release of IL-1beta, TNF-alpha, and IL-6. Hydrogen Peroxide 37-54 interleukin 6 Homo sapiens 137-141 29951874-5 2018 In the present study, we showed that hydrogen peroxide (H2O2) remarkably enhances the expression and release of IL-1beta, TNF-alpha, and IL-6. Hydrogen Peroxide 56-60 interleukin 6 Homo sapiens 137-141 29851525-4 2018 RESULTS: In T2D patients with high blood glucose, IL-1beta expression showed a 2.69-fold increase (p = 0.0380), while IL-6 expression levels were 3.45 fold lower (p = 0.0045) versus control subjects. Glucose 41-48 interleukin 6 Homo sapiens 118-122 29851525-5 2018 Moreover, compared with control group the expression of IL1R1 and IL-6 genes both were downregulated in individuals with moderately high blood glucose levels by 2.38 (p = 0.0365) and 4.34 fold (p = 0.0027), respectively. Glucose 143-150 interleukin 6 Homo sapiens 66-70 29851525-6 2018 In addition, hemoglobin A1C (A1C) levels were positively correlated with IL-1beta expression and fasting plasma glucose (FPG) levels showed a positive correlation with IL-1beta and a negative correlation with IL-6 expression. Glucose 112-119 interleukin 6 Homo sapiens 209-213 30076857-10 2018 Our data suggest that the attenuation of palmitate-induced TNF-alpha and IL-6 gene expression and protein secretion by vitamin D are associated with reduced activation of JNK and ERK1/2. Vitamin D 119-128 interleukin 6 Homo sapiens 73-77 29873573-11 2018 Systolic blood pressure and total cholesterol levels had a significantly positive relationship, whereas triglyceride levels had a significantly inverse relationship with the levels of IL-6. Triglycerides 104-116 interleukin 6 Homo sapiens 184-188 30345312-4 2018 The beneficial effect of CGM was also clear from the significant increase (p <0.001) in endogenous antioxidants (GSH, SOD, and GPx) and decrease in inflammatory markers (IL-6 and CRP) levels (p <0.001) as compared to both the baseline and placebo group. cgm 25-28 interleukin 6 Homo sapiens 173-185 30020457-8 2018 In youth with T1D, glucose rate of disappearance correlated with free fatty acid at the 80-mU/m2/min phase (P = 0.005), markers of inflammation (IL-6; P = 0.012), high-sensitivity C-reactive protein (P = 0.001), and leptin (P = 0.008)], but not hemoglobin A1c. Glucose 19-26 interleukin 6 Homo sapiens 145-149 29572131-8 2018 Participants in the highest quartile of DBR had higher nitrotyrosine, 8-isoPGF2a, interleukin-6, C-reactive protein and lower Montreal Cognitive Assessment score compared with those in the lowest quartile. dbr 40-43 interleukin 6 Homo sapiens 82-95 29661598-8 2018 However, a decrease in IL6 levels over the 2 years significantly correlated with reaching a normal vitamin D level (OR=0.89 per+1pg/mL IL6 increase, 95% CI=0.81-0.97, P=0.015). Vitamin D 99-108 interleukin 6 Homo sapiens 23-26 29936334-6 2018 GR sensitivity was evaluated in vitro by assessing the Dex inhibition of lipopolysaccharide (LPS)-stimulated IL-6 and TNF-alpha levels. Dexamethasone 55-58 interleukin 6 Homo sapiens 109-113 30039507-6 2018 This way we were able to show that the decrease of cerebral ACh triggers increased secretion of IL-1beta, IL-6, TNFalpha, MIP-2 (CCL3), RANTES, MCP1, IFNgamma, and IP-10. Acetylcholine 60-63 interleukin 6 Homo sapiens 106-110 30007092-10 2018 PD98059, an ERK inhibitor, decreased IL-6 generation under low dose of IL-17 but not with high dose. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 interleukin 6 Homo sapiens 37-41 29980616-8 2018 Secretomic analysis also showed that decreased NAD triggered interleukin-6 and transforming growth factor beta (TGFbeta) secretion, which activated integrin-beta-catenin, TGFbeta-MAPK, and inflammation signaling pathways to sustain the signaling required for EMT. NAD 47-50 interleukin 6 Homo sapiens 61-74 30486522-3 2018 The mechanism is mainly by inhibiting the activation of nuclear factor (NF-kappaB), mitogen-activated protein kinase (MAPKs) and signal transducers and activators of transcription (STAT) signaling pathways and down-regulating the inflammatory gene expression including tumor necrosis factor-alpha (TNF-alpha), prostaglandin E2 (PGE2), nitric oxide (NO), interleukin-1(IL-1), IL-6, IL-8 and other inflammatory factors. Dinoprostone 310-326 interleukin 6 Homo sapiens 375-379 30486522-3 2018 The mechanism is mainly by inhibiting the activation of nuclear factor (NF-kappaB), mitogen-activated protein kinase (MAPKs) and signal transducers and activators of transcription (STAT) signaling pathways and down-regulating the inflammatory gene expression including tumor necrosis factor-alpha (TNF-alpha), prostaglandin E2 (PGE2), nitric oxide (NO), interleukin-1(IL-1), IL-6, IL-8 and other inflammatory factors. Dinoprostone 328-332 interleukin 6 Homo sapiens 375-379 30486522-3 2018 The mechanism is mainly by inhibiting the activation of nuclear factor (NF-kappaB), mitogen-activated protein kinase (MAPKs) and signal transducers and activators of transcription (STAT) signaling pathways and down-regulating the inflammatory gene expression including tumor necrosis factor-alpha (TNF-alpha), prostaglandin E2 (PGE2), nitric oxide (NO), interleukin-1(IL-1), IL-6, IL-8 and other inflammatory factors. Nitric Oxide 335-347 interleukin 6 Homo sapiens 375-379 30026080-4 2018 We show that the presence of the dexamethasone prodrug LD003 effectively suppresses production of cytokines such as KC-GRO, TNFalpha, IL-1beta and IL-6 following intravenous administration of LNP loaded with immune stimulatory oligodeoxynucleotides containing cytosine-guanine dinucleotide motifs. Dexamethasone 33-46 interleukin 6 Homo sapiens 147-151 30236152-8 2018 In contrast, DEX was the strongest inhibitor of IL-6, IL-8, and tissue-destructive enzymes in RASF. Dexamethasone 13-16 interleukin 6 Homo sapiens 48-52 30254419-3 2018 Results: PMACI results in a significant increase in the production of proinflammatory cytokines, such as TNF-alpha, IL-1beta, MCP-1, IL-6 and as well as histamine. pmaci 9-14 interleukin 6 Homo sapiens 133-137 30294279-5 2018 Proinflammatory cytokine, mainly IL-6, which are released by both tumor and immune cells, play a pivotal action in CRA etiopathogenesis: they promote alterations in erythroid progenitor proliferation, erythropoietin (EPO) production, survival of circulating erythrocytes, iron balance, redox status, and energy metabolism, all of which can lead to anemia. Iron 272-276 interleukin 6 Homo sapiens 33-37 30231482-6 2018 In addition, the ATP-induced increase in [Ca2+]i coordinately activated Erk1/2, p38 MAPK and mTOR that upregulated translation of JunB and interleukin-6. Adenosine Triphosphate 17-20 interleukin 6 Homo sapiens 139-152 29691294-5 2018 In addition, CSCs remodeled their specific niche by educating monocytes/macrophages toward TAMs, and the CSC-educated TAMs reciprocally promoted the stem-like properties of CSCs, progression and ADT resistance of prostate cancer via IL6/STAT3. Tamoxifen 118-122 interleukin 6 Homo sapiens 233-236 29691294-6 2018 Furthermore, the combined targeting of CSCs and their interaction with TAMs by inhibiting ATG7/OCT4 and IL6 receptor effectively ameliorated ADT resistance in an orthotopic prostate cancer model.Conclusions: Targeting CSCs and their niche may prove to be a more powerful strategy than targeting CSCs alone, providing a rational approach to ameliorating ADT resistance in prostate cancer. Tamoxifen 71-75 interleukin 6 Homo sapiens 104-107 30215457-6 2018 Further, a significant increase in pro- and anti-inflammatory gene expression, as well as IL-6 secretion due to TC-medium-stimulation was measured. tc-medium 112-121 interleukin 6 Homo sapiens 90-94 30202238-9 2018 Conclusions: These results suggest that downregulation of hypermethylated in cancer-1 by miR-4532 could promote adriamycin resistance in breast cancer cells, in which the IL-6/STAT3 pathway was regulated by the HIC-1. Doxorubicin 112-122 interleukin 6 Homo sapiens 171-175 32254503-3 2018 The OECT gate electrode is functionalized with an oligo(ethylene glycol)-terminated self-assembled alkanethiolate monolayer (SAM) for both the immobilization of anti IL-6 antibodies and the inhibition of non-specific biomolecule binding. S-Adenosylmethionine 125-128 interleukin 6 Homo sapiens 166-170 29860063-5 2018 RESULTS: A significant relationship was observed between calcium level and IL-6 genotypes in osteoporotic males (P = 0.011) and females (P = 0.020). Calcium 57-64 interleukin 6 Homo sapiens 75-79 29860063-8 2018 CONCLUSION: IL-6 genotype influences serum calcium levels in osteoporotic patients. Calcium 43-50 interleukin 6 Homo sapiens 12-16 30237731-6 2018 After stimulation with LPS, we observed an exacerbated increase in TNF-alpha, IL-6, and MCP-1 concentration in the high glucose condition compared to the normal glucose environment. Glucose 120-127 interleukin 6 Homo sapiens 78-82 29656314-12 2018 In conclusion, CC homozygosis in the SNP - 174 G>C gene promoter of IL-6 can be proposed as one of the gene variants influencing iron accumulation in male adults with HFE mutations. Iron 132-136 interleukin 6 Homo sapiens 71-75 29859500-7 2018 Moreover, ChIP assays demonstrated that Jmjd3 was recruited to the promoters of interleukin-6 and interleukin-12b and this recruitment was associated with decreased levels of trimethylated histone 3 lysine 27 (H3K27). trimethylated histone 175-196 interleukin 6 Homo sapiens 80-93 29859500-7 2018 Moreover, ChIP assays demonstrated that Jmjd3 was recruited to the promoters of interleukin-6 and interleukin-12b and this recruitment was associated with decreased levels of trimethylated histone 3 lysine 27 (H3K27). Lysine 199-205 interleukin 6 Homo sapiens 80-93 30021340-12 2018 in vivo, berberine significantly reduced the levels of CRP, TNF-alpha and IL-6 in the patients" plasma. Berberine 9-18 interleukin 6 Homo sapiens 74-78 30335249-1 2018 Quinolinic acid activates NMDA receptors in the central nervous system and stimulates the secretion of interleukins IL-6 and 1L-1beta, among others, promoting hyper-activity of the HPA axis and reinforcing a bias of the tryptophan metabolism to produce quinolinic acid, and interleukins by the innate immune system, further reducing the synthesis of serotonin and consolidating the depressive process.We discuss the evidence showing that this process can be initiated by either interleukin stimulated by an infection or some vaccines or excessive psychological stress that activates the HPA axis together with said innate immune response, causing a process of aseptic inflammation in the central nervous system. Tryptophan 220-230 interleukin 6 Homo sapiens 116-133 30335249-1 2018 Quinolinic acid activates NMDA receptors in the central nervous system and stimulates the secretion of interleukins IL-6 and 1L-1beta, among others, promoting hyper-activity of the HPA axis and reinforcing a bias of the tryptophan metabolism to produce quinolinic acid, and interleukins by the innate immune system, further reducing the synthesis of serotonin and consolidating the depressive process.We discuss the evidence showing that this process can be initiated by either interleukin stimulated by an infection or some vaccines or excessive psychological stress that activates the HPA axis together with said innate immune response, causing a process of aseptic inflammation in the central nervous system. Serotonin 350-359 interleukin 6 Homo sapiens 116-133 30181391-0 2018 Editor"s Note: Capsaicin Is a Novel Blocker of Constitutive and Interleukin-6-Inducible STAT3 Activation. Capsaicin 15-24 interleukin 6 Homo sapiens 64-77 29909345-8 2018 Furthermore, macrophage phenotype switching by PLGA-PEG encapsulated Chr NPs significantly suppressed LPS/IFN-gamma induced inflammation by a remarkable reduction in pro-inflammatory cytokine levels, TNF-alpha, IL-1beta, and IL-6. Polyethylene Glycols 52-55 interleukin 6 Homo sapiens 225-229 30140651-10 2018 IL-6 concentration at 1h after therapy (2274.67+-2120.46 pg/mL) tended to be lower than before therapy (4330.09+-3169.70 pg/mL), but the difference was not statistically significant (P=0.821). Hydrogen 22-24 interleukin 6 Homo sapiens 0-4 30230255-8 2018 Additionally, in smooth muscle cells isolated from human AAA tissues, stimulation of CJ-42794 inhibited PGE2 -induced IL-6 secretion in a dose-dependent manner and decreased PGE2 -induced MMP-2 activity. Dinoprostone 104-108 interleukin 6 Homo sapiens 118-122 30157189-5 2018 Vitamin D altered expression of a subset of these PM-induced genes, including suppressing IL6. Vitamin D 0-9 interleukin 6 Homo sapiens 90-93 30157189-6 2018 Addition of vitamin D suppressed PM-stimulated IL-6 production, although to significantly greater extent in healthy versus asthmatic donor cultures. Vitamin D 12-21 interleukin 6 Homo sapiens 47-51 30157189-9 2018 Pre-treatment with vitamin D decreased CXCL8 and further decreased IL-6 production in PM-stimulated cultures, an effect abrogated by inhibition of G6PD with DHEA, supporting a role for this pathway in the anti-inflammatory actions of vitamin D. Vitamin D 19-28 interleukin 6 Homo sapiens 67-71 30154413-6 2018 Additionally, IL-6 treatment was found to enhance proliferation and iron accumulation in hPASMCs; intervention with LY2928057 prevented this response. Iron 68-72 interleukin 6 Homo sapiens 14-18 30154413-8 2018 Hepcidin or IL-6 mediated iron accumulation contributes to proliferation in hPASMCs; ferroportin mediated cellular iron excretion limits proliferation. Iron 26-30 interleukin 6 Homo sapiens 12-16 30154478-9 2018 In addition, CD46 engagement decreased the expressions of PRO-IL-1beta and NLRP3, enhanced the expression of scaffold protein GOPC, and diminished hydrogen peroxide-induced 8-OHdG, IL-1beta and IL-6 production. Hydrogen Peroxide 147-164 interleukin 6 Homo sapiens 194-198 30044000-10 2018 The main determinants for IL-6 level were intragraft lactate level, cold ischemia time, and anhepatic phase duration (P = 0.005). Lactic Acid 53-60 interleukin 6 Homo sapiens 26-30 30171593-11 2018 Prostaglandin E2 induces IL-17A independent of IL-23 via IL-1beta and IL-6. Dinoprostone 0-16 interleukin 6 Homo sapiens 70-74 28918107-8 2018 Depression was directly related to evening salivary cortisol and inflammation, such that higher evening cortisol predicted greater depressive symptoms (beta=0.215, p<0.01) and higher pro-inflammatory cytokines (interleukin-2 [IL-2], IL-6, and tumor necrosis factor-alpha [TNF-alpha] levels (beta=0.185, p<0.05), when controlling for covariates. Hydrocortisone 104-112 interleukin 6 Homo sapiens 236-240 29761497-10 2018 In addition, exogenous PGE2 increased IL-6 and IL-8 mRNA and protein expressions in hPDL cells. Dinoprostone 23-27 interleukin 6 Homo sapiens 38-42 29249192-4 2018 Here, we show exposure to doxorubicin doxorubicin (Dox) induced dramatic ATM (ataxia-telangiectasia-mutated)-dependent DNA damage response (DDR) and increased secretion of interleukin (IL)-6 in HS-5 cell line and primary BMSCs derived from healthy donors. Doxorubicin 26-37 interleukin 6 Homo sapiens 172-190 29249192-4 2018 Here, we show exposure to doxorubicin doxorubicin (Dox) induced dramatic ATM (ataxia-telangiectasia-mutated)-dependent DNA damage response (DDR) and increased secretion of interleukin (IL)-6 in HS-5 cell line and primary BMSCs derived from healthy donors. Doxorubicin 38-49 interleukin 6 Homo sapiens 172-190 29249192-4 2018 Here, we show exposure to doxorubicin doxorubicin (Dox) induced dramatic ATM (ataxia-telangiectasia-mutated)-dependent DNA damage response (DDR) and increased secretion of interleukin (IL)-6 in HS-5 cell line and primary BMSCs derived from healthy donors. Doxorubicin 51-54 interleukin 6 Homo sapiens 172-190 29249192-5 2018 Specifically, IL-6-containing conditioned media (CM) derived from Dox-pretreated stromal cells displayed significant protective effect on Dox-induced apoptosis of MM cells. Doxorubicin 66-69 interleukin 6 Homo sapiens 14-18 29249192-5 2018 Specifically, IL-6-containing conditioned media (CM) derived from Dox-pretreated stromal cells displayed significant protective effect on Dox-induced apoptosis of MM cells. Doxorubicin 138-141 interleukin 6 Homo sapiens 14-18 28703928-7 2018 RESULTS: We have found a peak of regulatory cytokines in RTR with low creatinine levels as well as a peak of IL-6 pro-inflammatory cytokine in patients with high creatinine levels. Creatinine 162-172 interleukin 6 Homo sapiens 109-113 30016752-2 2018 The aim of the study was to evaluate the influence of PDT with delta-aminolevulinic acid (ALA-PDT) used in sub-lethal dose on the interleukins secretion (IL-6, IL-8 and IL-10) by the residual colon cancer cells (CCC) under hypoxia-like conditions (addition of cobalt chloride- CoCl2). Alanine 90-93 interleukin 6 Homo sapiens 154-158 30016752-6 2018 After ALA-PDT we found no change in the IL-6 level secreted by SW480 cells, but decrease of IL-6, IL-10 secretion by SW620 cells, an increase in the IL-8 secreted by both cells lines. Alanine 6-9 interleukin 6 Homo sapiens 92-96 29802929-7 2018 More importantly, here we show that Resveratrol has the potential to abrogate the secretion of IL-6 by CAFs. Resveratrol 36-47 interleukin 6 Homo sapiens 95-99 30174670-9 2018 ER stress inducer thapsigargin (Tg, 100 and 500 nM) activated gene and protein expression of IL-6 and induced phosphorylation of p38 MAPK. Thapsigargin 18-30 interleukin 6 Homo sapiens 93-97 30174670-9 2018 ER stress inducer thapsigargin (Tg, 100 and 500 nM) activated gene and protein expression of IL-6 and induced phosphorylation of p38 MAPK. Thapsigargin 32-34 interleukin 6 Homo sapiens 93-97 30174670-10 2018 Both inhibition of p38 MAPK by SB203580 (10 microM) and knockdown of ER stress effector CCAAT-enhancer-binding protein homologous protein (CHOP) reduced gene and protein expression of IL-6 in Tg-treated cells. Thapsigargin 192-194 interleukin 6 Homo sapiens 184-188 30114226-10 2018 We also observed that plasma levels of the inflammatory cytokine IL-6, and both Kyn, and Trp, but not the Kyn/Trp ratio were higher with increasing plasma urea levels (F (2, 94) = 3.30, P = 0.041; F (2, 95) = 7.41, P<=0.001; F (2, 96) = 4.23, P = 0.017, respectively). Urea 155-159 interleukin 6 Homo sapiens 65-69 29856968-4 2018 In the in vitro model, the ABT-737 treatment diminished the levels of several inflammatory cytokines in this case vascular endothelial growth factor (VEGF), thymic stromal lymphopoietin (TSLP), interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha (TNF-alpha) by inhibiting caspase-1 and NF-kappaB activation in an activated human mast cell line, here HMC-1 cells. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid 27-30 interleukin 6 Homo sapiens 218-222 30110934-3 2018 The 2-(4-morpholinyl)-ethyl ester of CF3-substituted mollugin (compound 15c) showed good water solubility, improved metabolic and plasma stability, and greater inhibitory activity than mesalazine in both the TNF-alpha- and IL-6-induced colonic epithelial cell adhesion assays, suggesting that 15c is a potential anti-inflammatory agent. rubimaillin 53-61 interleukin 6 Homo sapiens 223-227 30238726-11 2018 Univariate analysis showed that the level of IL-6 in serum at 1 day after operation was significantly higher in variables as follows: age, diagnosis, history of lung infection, range of motion, preoperative levels of CRP and IL-6 in serum, intravenous dosage of tranexamic acid and dexamethasone on day of operation ( P<0.05). Dexamethasone 282-295 interleukin 6 Homo sapiens 45-49 30238726-13 2018 Conclusion: Range of motion less than 90 , intravenous dosage of tranexamic acid on day of operation less than 3 g, and dosage of dexamethasone on day of operation less than 10 mg were independent risk factors that resulted in increased level of IL-6 in serum at 1 day after TKA. Dexamethasone 130-143 interleukin 6 Homo sapiens 246-250 30537800-6 2018 We have found that nicotine (at concentration 0.01microM) induced release of TNF-a and IL-6 but not CXCL-8 production. Nicotine 19-27 interleukin 6 Homo sapiens 87-91 30069732-6 2018 Patients with steroid- and methotrexate-refractory AOSD can now benefit from efficient and well-tolerated biologic agents such as IL-1, IL-6, and tumor necrosis factor-alpha antagonists. Steroids 14-21 interleukin 6 Homo sapiens 136-140 30122920-6 2018 The NIPAM-hemin copolymer induced the production of interferon (IFN)-gamma and interleukin (IL)-6 from peripheral blood mononuclear cells, although hemin and the NIPAM monomer individually did not induce the production of any cytokines. N-isopropylacrylamide 4-9 interleukin 6 Homo sapiens 79-97 29807795-4 2018 CG-06 inhibited STAT3 phosphorylation at tyrosine 705 in a dose- and time dependent manner in DU-145 cells and suppressed IL-6-induced STAT3 phosphorylation at Tyr-705 in DU-145 and LNCaP cell lines. Tyrosine 160-163 interleukin 6 Homo sapiens 122-126 29902349-0 2018 Nab-paclitaxel interrupts cancer-stromal interaction through C-X-C motif chemokine 10-mediated interleukin-6 downregulation in vitro. Paclitaxel 4-14 interleukin 6 Homo sapiens 95-108 29784660-4 2018 We show that IL-6 couples autophagy to antioxidant response and thereby reduces ROS in beta-cells and human islets. Reactive Oxygen Species 80-83 interleukin 6 Homo sapiens 13-17 29784660-5 2018 beta-Cell-specific loss of IL-6 signaling in vivo renders mice more susceptible to oxidative damage and cell death through the selective beta-cell toxins streptozotocin and alloxan. Streptozocin 154-168 interleukin 6 Homo sapiens 27-31 29784660-6 2018 IL-6-driven ROS reduction is associated with an increase in the master antioxidant factor NRF2, which rapidly translocates to the mitochondria to decrease mitochondrial activity and stimulate mitophagy. Reactive Oxygen Species 12-15 interleukin 6 Homo sapiens 0-4 29784660-7 2018 IL-6 also initiates a robust transient decrease in cellular cAMP levels, likely contributing to the stimulation of mitophagy to mitigate ROS. Cyclic AMP 60-64 interleukin 6 Homo sapiens 0-4 29784660-7 2018 IL-6 also initiates a robust transient decrease in cellular cAMP levels, likely contributing to the stimulation of mitophagy to mitigate ROS. Reactive Oxygen Species 137-140 interleukin 6 Homo sapiens 0-4 30116326-2 2018 In addition, the influence of vitamin D deficiency was investigated on the expression of cytokines IL-1beta, IL-6 and TNF-alpha in intervertebral disc lesions of patients. Vitamin D 30-39 interleukin 6 Homo sapiens 109-113 30116326-11 2018 In the control group, vitamin D content was negatively correlated with the expression of IL-1beta, IL-6 and TNF-alpha. Vitamin D 22-31 interleukin 6 Homo sapiens 99-103 29806793-0 2018 Curcumin reduces the expression of interleukin 1beta and the production of interleukin 6 and tumor necrosis factor alpha by M1 macrophages from patients with Behcet"s disease. Curcumin 0-8 interleukin 6 Homo sapiens 75-120 30154906-6 2018 Furthermore, KJS018A diminished the effect of PMA, an inflammatory inducer via IL-6/STAT3/Cox-2 pathway. Tetradecanoylphorbol Acetate 46-49 interleukin 6 Homo sapiens 79-83 29728804-8 2018 Two inhibitors of SPHKs (FTY720 and ABC294640) suppressed titanium particle-induced tumour necrosis factor (TNF)-alpha and interleukin (IL)-6 production in RAW264.7 macrophages. Titanium 58-66 interleukin 6 Homo sapiens 123-141 29728804-9 2018 These findings suggest that persistent stimulation with titanium particles may lead to a consistent release of TNF-alpha and IL-6 via SPHK-2 activity, which may lead to aseptic implant loosening. Titanium 56-64 interleukin 6 Homo sapiens 125-129 29806793-6 2018 RESULTS: Treatment with 30 microg/ml curcumin significantly down-regulated mRNA expression of IL-1beta (p < .05) and protein production of IL-6 (p < .05) in M1 macrophages from BD patients but not in M1 macrophage from controls. Curcumin 37-45 interleukin 6 Homo sapiens 142-146 29803913-0 2018 Combination of 4-hydroperoxy cyclophosphamide and methotrexate inhibits IL-6/sIL-6R-induced RANKL expression in fibroblast-like synoviocytes via suppression of the JAK2/STAT3 and p38MAPK signaling pathway. perfosfamide 15-45 interleukin 6 Homo sapiens 72-76 29767234-6 2018 Furthermore, the combination of miR-125a-5p and cisplatin markedly inactivated the STAT3 signaling pathway; however, interleukin (IL)-6, a widely reported activator of the STAT3 signaling pathway, reversed the suppressive effects of miR-125a-5p/cisplatin in ESCC cells on the activation of the STAT3 signaling pathway. mir-125a-5p 233-244 interleukin 6 Homo sapiens 117-135 29907916-8 2018 CONCLUSIONS: In summary, the current meta-analysis showed the promising effect of melatonin administration on reducing CRP and IL-6, but not TNF-alpha levels among patients with MetS and related disorders. Melatonin 82-91 interleukin 6 Homo sapiens 127-131 29890415-6 2018 Montelukast has an inhibitory effect on the inflammatory microenvironment of RA by decreasing the secretion of IL-6, IL-8, MMP-3 and MMP-13 in FLSs induced by IL-1beta. montelukast 0-11 interleukin 6 Homo sapiens 111-115 29767234-6 2018 Furthermore, the combination of miR-125a-5p and cisplatin markedly inactivated the STAT3 signaling pathway; however, interleukin (IL)-6, a widely reported activator of the STAT3 signaling pathway, reversed the suppressive effects of miR-125a-5p/cisplatin in ESCC cells on the activation of the STAT3 signaling pathway. Cisplatin 245-254 interleukin 6 Homo sapiens 117-135 29767234-7 2018 Of note, we found that IL-6 markedly reversed the altered cell phenotype mediated by the combination of miR-125a-5p and cisplatin in ESCC cells. mir-125a-5p 104-115 interleukin 6 Homo sapiens 23-27 29767234-7 2018 Of note, we found that IL-6 markedly reversed the altered cell phenotype mediated by the combination of miR-125a-5p and cisplatin in ESCC cells. Cisplatin 120-129 interleukin 6 Homo sapiens 23-27 29452178-9 2018 The decrease in serum leptin with canagliflozin was correlated with change in weight (r >= 0.3) only; the increase in adiponectin and decrease in IL-6 with canagliflozin occurred independently of changes in HbA1c, weight, or lipids. Canagliflozin 159-172 interleukin 6 Homo sapiens 149-153 30128492-8 2018 Results: Expression levels of ANGPTL3, IL-1beta, IL-6, Bax, P53, VEGF, and integrin alphaVbeta3 were found to be upregulated after high-glucose stimulation or ANGPTL3 overexpression in HRMECs or diabetic retinal tissue. Glucose 136-143 interleukin 6 Homo sapiens 49-53 29452178-10 2018 CONCLUSIONS: These results indicate that canagliflozin may improve adipose tissue function and induce changes in serum leptin, adiponectin, and IL-6 that favorably impact insulin sensitivity and cardiovascular disease risk. Canagliflozin 41-54 interleukin 6 Homo sapiens 144-148 29845248-6 2018 Furthermore, Letinous edodes foot peptides inhibited the ethanol-induced activation of the proinflammatory cytokines, interleukin-6 and tumor necrosis factor-alpha, and promoted the metabolic regulation factors, AMP-activated protein kinase-alpha2 and peroxisome proliferator-activated receptor-alpha. Ethanol 57-64 interleukin 6 Homo sapiens 118-163 30078983-12 2018 In addition, tyloxapol, another excipient, showed some anti-inflammatory activity on IL-6 and IL-8 in the LPS-stimulated HCE-2 cells. tyloxapol 13-22 interleukin 6 Homo sapiens 85-89 29723596-4 2018 The HA-CL - SAP displayed the most significant reduction in interleukin-6 (IL-6) and reactive oxygen species (ROS) levels, due to the combined action of HA-CL and SAP. ha-cl 4-9 interleukin 6 Homo sapiens 60-73 29723596-4 2018 The HA-CL - SAP displayed the most significant reduction in interleukin-6 (IL-6) and reactive oxygen species (ROS) levels, due to the combined action of HA-CL and SAP. ha-cl 4-9 interleukin 6 Homo sapiens 75-79 30037344-10 2018 Quantitative real-time PCR analysis revealed that curcumin, but not rapamycin, reduced the levels of inflammatory markers IL-6 and COX-2 in cultured astrocytes that were challenged with IL-1beta. Curcumin 50-58 interleukin 6 Homo sapiens 122-126 30012134-0 2018 Curcumin derivative, 2,6-bis(2-fluorobenzylidene)cyclohexanone (MS65) inhibits interleukin-6 production through suppression of NF-kappaB and MAPK pathways in histamine-induced human keratinocytes cell (HaCaT). Histamine 158-167 interleukin 6 Homo sapiens 79-92 30029001-3 2018 Here we show that polarized M2 macrophages enhance 3-phosphoinositide-dependent protein kinase 1 (PDPK1)-mediated phosphoglycerate kinase 1 (PGK1) threonine (T) 243 phosphorylation in tumor cells by secreting interleukin-6 (IL-6). Threonine 147-156 interleukin 6 Homo sapiens 209-222 30029001-3 2018 Here we show that polarized M2 macrophages enhance 3-phosphoinositide-dependent protein kinase 1 (PDPK1)-mediated phosphoglycerate kinase 1 (PGK1) threonine (T) 243 phosphorylation in tumor cells by secreting interleukin-6 (IL-6). Threonine 147-156 interleukin 6 Homo sapiens 224-228 30012134-6 2018 METHODS: Interleukin (IL)-6 cytokine production in histamine-induced HaCaT cells were measured using enzyme-linked immunosorbent assay (ELISA) and cytotoxicity effects were determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Histamine 51-60 interleukin 6 Homo sapiens 9-27 30012134-0 2018 Curcumin derivative, 2,6-bis(2-fluorobenzylidene)cyclohexanone (MS65) inhibits interleukin-6 production through suppression of NF-kappaB and MAPK pathways in histamine-induced human keratinocytes cell (HaCaT). Curcumin 0-8 interleukin 6 Homo sapiens 79-92 30012134-8 2018 RESULTS: Histamine enhanced IL-6 production in HaCaT cells, with the highest production of IL-6 at 97.41 +- 2.33 pg/mL after 24 h of exposure. Histamine 9-18 interleukin 6 Homo sapiens 28-32 30012134-8 2018 RESULTS: Histamine enhanced IL-6 production in HaCaT cells, with the highest production of IL-6 at 97.41 +- 2.33 pg/mL after 24 h of exposure. Histamine 9-18 interleukin 6 Homo sapiens 91-95 30001365-11 2018 Further, C/C genotype of IL-6 (G/C), T/T of CRP (C/T) and RR genotype of LEPR (Q/R) was associated with significantly higher BMI, fat mass (kg), % body fat, waist circumference, serum triglycerides, total cholesterol, alkaline phosphate, aspartate transaminase and fasting insulin levels in OSA and NAFLD subjects. Triglycerides 184-197 interleukin 6 Homo sapiens 25-29 28478304-3 2018 In turn, increased amounts of ROS/RNS and pro-inflammatory cytokines TNFalpha, IL-1beta, IL-6 led to the irreversible DNA damage, persistent DDR activation, proliferation inhibition, reduction in cell growth and immune impairment. ros 30-33 interleukin 6 Homo sapiens 89-93 30006619-7 2018 S1P3 mediates its effects on BTB permeability through astrocytic secretion of IL-6 and CCL2, which relaxes endothelial cell adhesion. btb 29-32 interleukin 6 Homo sapiens 78-82 30001365-11 2018 Further, C/C genotype of IL-6 (G/C), T/T of CRP (C/T) and RR genotype of LEPR (Q/R) was associated with significantly higher BMI, fat mass (kg), % body fat, waist circumference, serum triglycerides, total cholesterol, alkaline phosphate, aspartate transaminase and fasting insulin levels in OSA and NAFLD subjects. Cholesterol 205-216 interleukin 6 Homo sapiens 25-29 30001365-11 2018 Further, C/C genotype of IL-6 (G/C), T/T of CRP (C/T) and RR genotype of LEPR (Q/R) was associated with significantly higher BMI, fat mass (kg), % body fat, waist circumference, serum triglycerides, total cholesterol, alkaline phosphate, aspartate transaminase and fasting insulin levels in OSA and NAFLD subjects. alkaline phosphate 218-236 interleukin 6 Homo sapiens 25-29 29730525-6 2018 Since IL-1beta production leads to increased levels of IL-6 and C-reactive protein, this could be a mechanistic link between early deposition of cholesterol crystals within the vessel wall to the macrophage-monocyte interactions that initiate fatty streaks and promote local atherosclerotic progression. Cholesterol 145-156 interleukin 6 Homo sapiens 55-59 29635121-6 2018 KEY FINDINGS: NAC at high concentrations normalized the peroxidase activity, H2O2, malondialdehyde (MDA), nitric oxide, glutathione (GSH), total antioxidant capacity (TAC), and interleukin 6 (IL-6) (overall change 34.32% +- 4.22%, P < 0.05 vs. LPS-treated). Acetylcysteine 14-17 interleukin 6 Homo sapiens 177-190 29635121-6 2018 KEY FINDINGS: NAC at high concentrations normalized the peroxidase activity, H2O2, malondialdehyde (MDA), nitric oxide, glutathione (GSH), total antioxidant capacity (TAC), and interleukin 6 (IL-6) (overall change 34.32% +- 4.22%, P < 0.05 vs. LPS-treated). Acetylcysteine 14-17 interleukin 6 Homo sapiens 192-196 29653184-7 2018 Furthermore, the mRNA expression of inflammatory mediators such as Il-1beta, Il-6, iNos, and Cox-2 was more attenuated in 17beta-estradiol-treated group than in vehicle-treated group. Estradiol 122-138 interleukin 6 Homo sapiens 77-81 29635121-7 2018 NAC at low concentrations modulated peroxidase activity, H2O2, MDA, GSH, TAC, and IL-6 (overall change 34.88% +- 7.39%, P < 0.05 vs. LPS-treated). Acetylcysteine 0-3 interleukin 6 Homo sapiens 82-86 29635121-8 2018 NAC at very-low concentrations was effective on peroxidase activity, H2O2, GSH, and IL-6 (overall change 35.05 +- 7.71%, P < 0.05 vs. LPS-treated). Acetylcysteine 0-3 interleukin 6 Homo sapiens 84-88 29635121-9 2018 Binary logistic regression analysis indicated that the modulatory effect of NAC on NKA levels was associated with a reduction of pro-oxidant factors and IL-6, and selectively blocking the NK2 receptor abolished such an association. Acetylcysteine 76-79 interleukin 6 Homo sapiens 153-157 29635121-10 2018 SIGNIFICANCE: This study demonstrates that, along with its well-known antioxidant activity, the protective effect of NAC against the detrimental effect of LPS is due to the modulation of NKA and IL-6 levels. Acetylcysteine 117-120 interleukin 6 Homo sapiens 195-199 29457280-8 2018 Besides, levels of PE750, PI885, PC792, PC826, PC830, PC854, PC802, and PG747 had an obvious negative correlation with levels of TNF-alpha, IL-10, IL-6, BUN, SCr, and PaCO2 , and a significant positive correlation with levels of HCO3- , PaO2 , and SaO2 . Bicarbonates 229-233 interleukin 6 Homo sapiens 147-151 30016181-13 2018 As expected, UFH decreased LPS-induced IL-1beta, TNF-alpha, IL-6, IL-8, and IL-18 protein levels, suggesting that UFH has an anti-inflammatory effect on THP-1 cells by interrupting the MAPK, NF-kappaB, and c-Jun signaling pathways. Heparin 13-16 interleukin 6 Homo sapiens 60-64 29932110-6 2018 Of these, only (2-(1,2-diphenyl-1H-indol-3-yl)ethanamine (DPIE) showed a synergistic increase in inflammatory molecules and cytokine production (IL-6, IL-8, and COX-2) at both mRNA and protein levels in IL-1&beta;-stimulated GFs. dpie 58-62 interleukin 6 Homo sapiens 145-149 30211239-0 2018 Trial of Atorvastatin on Serum Interleukin-6, Total Antioxidant Capacity, C-Reactive Protein, and Alpha-1 Antitrypsin in Patients with Chronic Obstructive Pulmonary Disease. Atorvastatin 9-21 interleukin 6 Homo sapiens 31-44 30211239-14 2018 However, less reduction in AAT and more reduction in IL-6 in the atorvastatin group would be likely a beneficial effect in COPD. Atorvastatin 65-77 interleukin 6 Homo sapiens 53-57 29128906-7 2018 HIV-1 upregulated IL6 through interleukin-1 receptor-associated-kinase (IRAK)-1/4/TAK1/JNK pathways, via ATP-dependent JNK activation. Adenosine Triphosphate 105-108 interleukin 6 Homo sapiens 18-21 29128906-8 2018 TLR3 activation upregulated IL6 through TAK1/JNK pathways, via ATP-dependent or -independent JNK activation. Adenosine Triphosphate 63-66 interleukin 6 Homo sapiens 28-31 29529950-4 2018 Here, we tested the prediction that a high-sensitivity multiplex assay (human Magnetic Luminex Performance Assay, R&D Systems, Minneapolis, MN) would detect changes in IL-6 as a result of acute stress challenge in a manner comparable to high-sensitivity ELISA. Adenosine Monophosphate 116-119 interleukin 6 Homo sapiens 172-176 29946898-0 2018 Study of melatonin-mediated effects on various hepatic inflammatory responses stimulated by IL-6 in a new HepG2-on-a-chip platform. Melatonin 9-18 interleukin 6 Homo sapiens 92-96 29946898-3 2018 The key role of the liver to maintain homeostasis and metabolic regulation prompted us to evaluate the direct modification of IL-6-induced alterations in HepG2 cells in a chip by melatonin. Melatonin 179-188 interleukin 6 Homo sapiens 126-130 29946898-6 2018 IL-6 affected also the mitochondrial membrane potential together with elevated mitochondrial superoxide generation, and glycogen deposition was reduced. Superoxides 93-103 interleukin 6 Homo sapiens 0-4 29946898-7 2018 Melatonin counteracted all observed IL-6-induced alterations except the rise in CRP release and CYP1A activity. Melatonin 0-9 interleukin 6 Homo sapiens 36-40 29946898-8 2018 Altogether, this new in vitro model can be applied to investigate hepatic inflammatory responses stimulated by IL-6, and these results indicate that hepatocellular inflammatory responses to IL-6 are mitigated by melatonin. Melatonin 212-221 interleukin 6 Homo sapiens 111-115 29946898-8 2018 Altogether, this new in vitro model can be applied to investigate hepatic inflammatory responses stimulated by IL-6, and these results indicate that hepatocellular inflammatory responses to IL-6 are mitigated by melatonin. Melatonin 212-221 interleukin 6 Homo sapiens 190-194 29540537-7 2018 Expression of active form of AMP-activated protein kinase was reduced in inflammatory bowel disease patients and treatment of mucosal cells of such patients with metformin enhanced AMP-activated protein kinase activation and reduced p38 MAP kinase activation, thereby inhibiting interleukin-6 expression. Metformin 162-171 interleukin 6 Homo sapiens 279-292 29808220-7 2018 However, incubation with proanthocyanidin dimers prevented LPS-mediated oxidative stress, including the increase of SOD, HO-1, CAT, and GSH-Px mRNA expression, and counteracted LPS-mediated inflammation as evidenced by the down-regulation of inflammatory markers (NF-kappabeta, IL-6, and TNF-alpha mRNA expression). proanthocyanidin 25-41 interleukin 6 Homo sapiens 278-282 29704506-10 2018 RSV also inhibited inflammation injury of HaCaT cells by reducing productions of IL-6, IL-8, and TNF-alpha. Resveratrol 0-3 interleukin 6 Homo sapiens 81-85 29984230-10 2018 Of the compounds isolated, betulin showed the greatest inhibitory effects on IL-6-induced STAT3 activation in the luciferase assay (IC50 value: 3.12 muM). betulin 27-34 interleukin 6 Homo sapiens 77-81 29895782-2 2018 EtOH increased senescence activity, levels of reactive oxygen species (ROS) and the expression of cell cycle regulators (p53, p21 and p16) and senescence-associated secretory phenotype (SASP) genes (interleukin [IL]-1beta, IL-6, IL-8 and tumor necrosis factor-alpha) in HPDLCs and cementoblasts. Ethanol 0-4 interleukin 6 Homo sapiens 223-227 29689344-0 2018 The relationship between interleukin-6 and functional connectivity in methamphetamine users. Methamphetamine 70-85 interleukin 6 Homo sapiens 25-38 29895317-8 2018 The hypoxia tension (1% O2) significantly increased vascular endothelial growth factor (VEGF) secretion and decreased interleukin (IL)-6, IL-7, stem cell factor (SCF), and thrombopoietin (TPO) secretion of WJ-MSCs, and selectively activated the Notch, Wnt/beta-catenin, and Hedgehog signaling pathway of cord blood HSPCs by HIF-related factors, which may play an important role in stemness preservation and for sustaining HSPC quiescence. Oxygen 24-26 interleukin 6 Homo sapiens 118-136 29877315-7 2018 Procalcitonin (PCT), interleukin 6 (IL-6), and C-reactive protein concentrations were higher in patients with AdP than in those with URI. Adenosine Diphosphate 110-113 interleukin 6 Homo sapiens 21-34 29877315-7 2018 Procalcitonin (PCT), interleukin 6 (IL-6), and C-reactive protein concentrations were higher in patients with AdP than in those with URI. Adenosine Diphosphate 110-113 interleukin 6 Homo sapiens 36-40 29915584-8 2018 In vitro analysis demonstrated that the blockade of autophagy with 3-methyladenine (3-MA) in Mycobacterium leprae-stimulated human primary monocytes increased the assembly of NLRP3 specks assembly, and it was associated with an increase of IL-1beta and IL-6 production. 3-methyladenine 67-82 interleukin 6 Homo sapiens 253-257 29874560-1 2018 Actions of Interleukin-6 on Glucose Tolerance. Glucose 28-35 interleukin 6 Homo sapiens 11-24 29874560-4 2018 (2018) demonstrate that IL-6 infusion has GLP-1-dependent and -independent actions with opposing effects on glucose tolerance, resulting in an overall improvement in healthy male volunteers but no improvement in male patients with diabetes. Glucose 108-115 interleukin 6 Homo sapiens 24-28 29915584-8 2018 In vitro analysis demonstrated that the blockade of autophagy with 3-methyladenine (3-MA) in Mycobacterium leprae-stimulated human primary monocytes increased the assembly of NLRP3 specks assembly, and it was associated with an increase of IL-1beta and IL-6 production. 3-methyladenine 84-88 interleukin 6 Homo sapiens 253-257 29446169-5 2018 RESULTS: Physiological normoxia (5% O2 ) decreased SA-beta-Gal-positive cells and SASP including interleukin-6 (IL-6) and IL-8 compared with cultured cells in 21% O2 . Oxygen 36-38 interleukin 6 Homo sapiens 97-110 29568915-8 2018 Furthermore, it was confirmed that the signaling pathways involving CX3CL1-NF-kappaB, IL-6 and TNF-alpha were partly inhibited by aspirin. Aspirin 130-137 interleukin 6 Homo sapiens 86-90 28595461-5 2018 The Chr-blended PCL/PEG nanofibrous mats also reduced overexpression of IL-6, IL-1beta, TNF-alpha and excessive production of nitric oxide (NO) in J774A1 following stimulation by lipopolysaccharide (LPS). Polyethylene Glycols 20-23 interleukin 6 Homo sapiens 72-76 29550635-1 2018 Glycine modulates inflammatory processes mediated by macrophages and adipocytes through decreasing the secretion of TNF-alpha, IL-6, and leptin, while increasing adiponectin. Glycine 0-7 interleukin 6 Homo sapiens 127-131 29550635-7 2018 Glycine decreased the IKK-alpha/beta complex and the phosphorylation of NF-kappaB, diminishing the expression and secretion of IL-6 and TNF-alpha, but increasing that of adiponectin. Glycine 0-7 interleukin 6 Homo sapiens 127-131 29704732-3 2018 Paeonol pretreatment showed statistically significant reduction in alcohol-induced ROS, MDA, IL-1beta, IL-6, TNF-alpha, and nitric oxide, while GSH content was retained (P < 0.05). Alcohols 67-74 interleukin 6 Homo sapiens 103-107 29949172-7 2018 CONCLUSIONS: The prolonged sevoflurane inhalational anesthesia time (>= 3 h) enhanced the occurrence of POCD and was related to the expression levels of serum caspase-3, TNF-alpha, and IL-6. Sevoflurane 27-38 interleukin 6 Homo sapiens 188-192 29508109-3 2018 On the other hand, an increasing number of evidence suggests that IL-6 has an anti-inflammatory role and improves glucose metabolism. Glucose 114-121 interleukin 6 Homo sapiens 66-70 29368548-5 2018 We found that the omega-6 PUFA arachidonic acid (AA), but not omega-3 PUFAs or SFAs, upregulates IL-6 and CXCL8 release. Arachidonic Acid 31-47 interleukin 6 Homo sapiens 97-101 29446169-5 2018 RESULTS: Physiological normoxia (5% O2 ) decreased SA-beta-Gal-positive cells and SASP including interleukin-6 (IL-6) and IL-8 compared with cultured cells in 21% O2 . Oxygen 36-38 interleukin 6 Homo sapiens 112-116 29777330-0 2018 Down-regulating IL-6/GP130 targets improved the anti-tumor effects of 5-fluorouracil in colon cancer. Fluorouracil 70-84 interleukin 6 Homo sapiens 16-20 29777330-4 2018 Thus, we speculated that in colon cancer, the anti-tumor efficacy of 5-FU might be increased in combination with IL-6/GP130 inhibitors. Fluorouracil 69-73 interleukin 6 Homo sapiens 113-117 29777330-14 2018 Conversely, 5-FU activation is reduced following exogenous IL-6 treatment in cells. Fluorouracil 12-16 interleukin 6 Homo sapiens 59-63 29777330-15 2018 Further mechanistic studies determined that BZA treatment enhanced 5-FU anti-tumor activation by inhibiting the IL-6/GP130 signaling pathway and the phosphorylation status of the downstream effectors AKT, ERK and STAT3. Fluorouracil 67-71 interleukin 6 Homo sapiens 112-116 29777330-16 2018 In contrast, IL-6 can attenuate 5-FU function via activating IL-6R/GP130 signaling and the P-AKT, P-ERK and P-STAT3 levels. Fluorouracil 32-36 interleukin 6 Homo sapiens 13-17 29553088-6 2018 Treatment with ATP, a ligand of P2Y11 receptor caused IL-6 production within 24 h. ATP-induced IL-6 production was also suppressed by NF157. Adenosine Triphosphate 15-18 interleukin 6 Homo sapiens 54-58 29553088-6 2018 Treatment with ATP, a ligand of P2Y11 receptor caused IL-6 production within 24 h. ATP-induced IL-6 production was also suppressed by NF157. Adenosine Triphosphate 15-18 interleukin 6 Homo sapiens 95-99 29553088-6 2018 Treatment with ATP, a ligand of P2Y11 receptor caused IL-6 production within 24 h. ATP-induced IL-6 production was also suppressed by NF157. Adenosine Triphosphate 83-86 interleukin 6 Homo sapiens 54-58 29553088-6 2018 Treatment with ATP, a ligand of P2Y11 receptor caused IL-6 production within 24 h. ATP-induced IL-6 production was also suppressed by NF157. Adenosine Triphosphate 83-86 interleukin 6 Homo sapiens 95-99 29660364-2 2018 Silibinin reduced IL-6 inducible, constitutive, and acquired feedback activation of STAT3 at tyrosine 705 (Y705). Silybin 0-9 interleukin 6 Homo sapiens 18-22 29660364-2 2018 Silibinin reduced IL-6 inducible, constitutive, and acquired feedback activation of STAT3 at tyrosine 705 (Y705). Tyrosine 93-101 interleukin 6 Homo sapiens 18-22 29658573-7 2018 The results indicated that A549 had increased levels of IL-6, IL-8 and TNF-alpha when cultured with nicotine when compared with the control cells. Nicotine 100-108 interleukin 6 Homo sapiens 56-60 28592206-6 2018 Conformational changes coupled with quantitative analysis of center of mass (COM) distance, radius of gyration (Rg), and number of intermolecular hydrogen bonds in each IL6 protein-aptamer complex was used to determine their binding performance strength and obtain molecular configurations with strong binding. Hydrogen 146-154 interleukin 6 Homo sapiens 169-172 30069319-14 2018 In 16HBE airway cells, H2O2 increased IL-6 and IL-8 secretion in conjunction with ERK1/2 and NF-kappaB activation. Hydrogen Peroxide 23-27 interleukin 6 Homo sapiens 38-42 29545331-5 2018 First, we found a significant stromal overexpression of IL6 in patient samples that received cisplatin-based treatment, which was further validated in purified fibroblasts challenged with cisplatin. Cisplatin 93-102 interleukin 6 Homo sapiens 56-59 29545331-5 2018 First, we found a significant stromal overexpression of IL6 in patient samples that received cisplatin-based treatment, which was further validated in purified fibroblasts challenged with cisplatin. Cisplatin 188-197 interleukin 6 Homo sapiens 56-59 29545331-7 2018 For the first time, we found that the tumor stroma of patients with routine metformin administration exhibited lower IL6 expression. Metformin 76-85 interleukin 6 Homo sapiens 117-120 29545331-10 2018 Mechanistically, we found that metformin inhibited IL6 secretion via suppressing NFkappaB signaling, an upstream controller of stromal inflammation. Metformin 31-40 interleukin 6 Homo sapiens 51-54 29510260-0 2018 Influence of ALA-mediated photodynamic therapy on secretion of interleukins 6, 8 and 10 by colon cancer cells in vitro. Alanine 13-16 interleukin 6 Homo sapiens 63-87 29844821-0 2018 Tumor-derived mesenchymal-stem-cell-secreted IL-6 enhances resistance to cisplatin via the STAT3 pathway in breast cancer. Cisplatin 73-82 interleukin 6 Homo sapiens 45-49 29844821-8 2018 Taken together, the findings of the present study indicated that BC-MSCs decreased the level of cisplatin-induced apoptosis in MCF-7 cells by activating the IL-6/STAT3 pathway in cancer cells. Cisplatin 96-105 interleukin 6 Homo sapiens 157-161 29510260-2 2018 The aim of our study was to investigate how photodynamic therapy with 5-aminolevulinic acid (ALA-PDT) in sublethal doses influences the secretion of interleukins 6, 8 and 10 from colon cancer cells in vitro. Alanine 93-96 interleukin 6 Homo sapiens 149-173 29510260-5 2018 RESULTS: Sublethal ALA-PDT did not affect IL-6 secretion by SW480 cells, but caused a 40% decrease of IL-6 release by the SW620 cell line. Alanine 19-22 interleukin 6 Homo sapiens 102-106 29510260-7 2018 CONCLUSIONS: ALA-PDT in sublethal doses might influence colon cancer cell"s progression and invasion by reducing the secretion of IL-6, IL-10 and increasing the IL-8 concentration with higher values in the more malignant cell line. Alanine 13-16 interleukin 6 Homo sapiens 130-134 29573703-4 2018 The aim of this work was to study the extent of the protective effect of the antioxidant N-acetylcysteine (NAC) over the proinflammatory state (IL-6 and IL-8), oxidative stress (reactive oxygen species, ROS), and CFTR levels, caused by Cigarette Smoke Extract (CSE) in Calu-3 airway epithelial cells. Acetylcysteine 89-105 interleukin 6 Homo sapiens 144-148 29573703-4 2018 The aim of this work was to study the extent of the protective effect of the antioxidant N-acetylcysteine (NAC) over the proinflammatory state (IL-6 and IL-8), oxidative stress (reactive oxygen species, ROS), and CFTR levels, caused by Cigarette Smoke Extract (CSE) in Calu-3 airway epithelial cells. Acetylcysteine 107-110 interleukin 6 Homo sapiens 144-148 29501468-11 2018 Vitamin D was inversely correlated with IL-6 (r = -0.36, p = 0.044) in critically ill controls. Vitamin D 0-9 interleukin 6 Homo sapiens 40-44 29501754-1 2018 In bovine adrenal zona fasciculata (ZF) and NCI-H295R cells, interleukin-6 (IL-6) increases cortisol release, increases expression of steroidogenic acute regulatory protein (StAR), cholesterol side chain cleavage enzyme (P450scc), and steroidogenic factor 1 (SF-1) (increases steroidogenic proteins), and decreases the expression of adrenal hypoplasia congenita-like protein (DAX-1) (inhibits steroidogenic proteins). Cholesterol 181-192 interleukin 6 Homo sapiens 61-74 29501754-1 2018 In bovine adrenal zona fasciculata (ZF) and NCI-H295R cells, interleukin-6 (IL-6) increases cortisol release, increases expression of steroidogenic acute regulatory protein (StAR), cholesterol side chain cleavage enzyme (P450scc), and steroidogenic factor 1 (SF-1) (increases steroidogenic proteins), and decreases the expression of adrenal hypoplasia congenita-like protein (DAX-1) (inhibits steroidogenic proteins). Cholesterol 181-192 interleukin 6 Homo sapiens 76-80 29789542-6 2018 We identified that the ERK reactivation occurs via the function of cytokines, such as IL-6, whose expression is transcriptionally induced in a gefitinib-dependent manner by RNF25-mediated NF-kappaB signals. Gefitinib 143-152 interleukin 6 Homo sapiens 86-90 30083334-8 2018 Notably, necrostatin-1, the specific inhibitor of the RIP3 signaling pathway, and 6-thioguanine (6-TG), the active metabolite of azathioprine, predominantly reduced IL-6 production compared to other cytokines. Thioguanine 82-95 interleukin 6 Homo sapiens 165-169 30083334-8 2018 Notably, necrostatin-1, the specific inhibitor of the RIP3 signaling pathway, and 6-thioguanine (6-TG), the active metabolite of azathioprine, predominantly reduced IL-6 production compared to other cytokines. Thioguanine 97-101 interleukin 6 Homo sapiens 165-169 29801502-7 2018 Fatty acids decreased the level of IL-6 and TNFalpha in supernatant in a ratio-dependent manner. Fatty Acids 0-11 interleukin 6 Homo sapiens 35-39 29768427-10 2018 The IL-17/IL-1beta combination with Cd slightly reduced cell viability in comparison to the IL-17/TNF-alpha combination and resulted in a strong induction of IL-6 production. Cadmium 36-38 interleukin 6 Homo sapiens 158-162 29609021-7 2018 We also demonstrated that compared with the IL-6 expression elicited by CRP alone (p = 0.0489), the CRP-induced rise in monocytic IL-6 mRNA and protein expression in the presence of nicotine (p = 0.0002), is mediated by alpha7-nAChR activation and the deregulation of the human p38 mitogen-activated protein kinases (MAPK) signaling pathway. Nicotine 182-190 interleukin 6 Homo sapiens 130-134 29609021-8 2018 CONCLUSIONS: Our data demonstrate that the elevated monocytic IL-6 and alpha7-nAChR mRNA and protein expression levels are associated with the interaction between nicotine and CRP positively modulates CAS development. Nicotine 163-171 interleukin 6 Homo sapiens 62-66 29861860-7 2018 Gene set enrichment analysis and iPathway analysis identified signaling pathways with major implications to the pathobiology of cancer (e.g. TNFalpha, IFN, IL6/STAT, NF-kappaB) that are enriched in cisplatin-resistant ALDHhighCD44high cells, when compared to control cells. Cisplatin 198-207 interleukin 6 Homo sapiens 156-159 29771935-7 2018 Further, iron loading of macrophages prevented the pro-inflammatory response induced by LPS through reduction of NF-kappaB p65 nuclear translocation with decreased iNOS, IL-1beta, IL-6, IL-12 and TNFalpha expression. Iron 9-13 interleukin 6 Homo sapiens 180-184 29761938-13 2018 Besides, the increase of IL-6 and PD-L1 in cisplatin-resistant HNSCC cells was abolished in vitro by LfcinB (P < .05). Cisplatin 43-52 interleukin 6 Homo sapiens 25-29 29657156-7 2018 The production of cytokines (TNF-alpha, IL-6, IL-4 and IL-10) could be regulated by titanium surface roughness. Titanium 84-92 interleukin 6 Homo sapiens 40-44 29483096-6 2018 Downstream of the beta-catenin cascade, IL6 mediated the motility-promoting functions of hPCL3s. hpcl3s 89-95 interleukin 6 Homo sapiens 40-43 29761938-10 2018 PD-L1 and IL-6 in the established cisplatin-resistant HNSCC cells were shown significantly higher (P < .05). Cisplatin 34-43 interleukin 6 Homo sapiens 10-14 29728589-0 2018 All-trans-retinoic acid activates the pro-invasive Src-YAP-Interleukin 6 axis in triple-negative MDA-MB-231 breast cancer cells while cerivastatin reverses this action. Tretinoin 0-23 interleukin 6 Homo sapiens 59-72 29728095-8 2018 RESULTS: Compared to the PM2.5-treated cells, in addition to inhibiting the PM2.5-induced VSMCs proliferation, puerarin also down-regulated the protein expressions of p-p38 MAPK and PCNA, decreased the levels of ET-1, VCAM-1, IL-6, TNF-alpha and MDA, increased the levels of NO and SOD. puerarin 111-119 interleukin 6 Homo sapiens 226-230 29728589-4 2018 We show here that RA activates the pro-invasive axis Src-YAP-Interleukin 6 (Src-YAP-IL6) in triple negative MDA-MB-231 breast cancer cells, yielding to increased invasion of these cells. Tretinoin 18-20 interleukin 6 Homo sapiens 61-74 29751535-7 2018 Furthermore, IL-1&beta;-stimulated SW982 cells secreted less inflammatory cytokines (TNF-&alpha; and IL-6), which is associated with the downregulation of p38-mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK), and NF-&kappa;B pathways. Adenosine Monophosphate 18-21 interleukin 6 Homo sapiens 109-113 28474088-12 2018 Conclusions Administering two doses of low-dose perioperative dexamethasone for patients receiving total knee arthroplasty reduces postoperative CRP and IL-6 levels, provides additional analgesic effect, and reduces the PONV incidence and postoperative fatigue, without increasing the risk of early surgical wound infection and gastrointestinal haemorrhage. Dexamethasone 62-75 interleukin 6 Homo sapiens 153-157 29494960-12 2018 In connection with that, I3C significantly attenuated DOX-induced inflammation by downregulation of pro-inflammatory mediators, viz., NF-kbeta(p50), iNOS, COX-2 and IL-6 expression. Doxorubicin 54-57 interleukin 6 Homo sapiens 165-169 28357449-10 2018 RESULTS: The results showed that myricetin blunted the overexpression of IL-1beta, IL-6, and TNF-alpha markedly by inhibiting the NF-kappaB/P65 signaling pathway. myricetin 33-42 interleukin 6 Homo sapiens 83-87 29432845-0 2018 ADAM9 mediates the interleukin-6-induced Epithelial-Mesenchymal transition and metastasis through ROS production in hepatoma cells. Reactive Oxygen Species 98-101 interleukin 6 Homo sapiens 19-32 29080374-7 2018 The expression of TNF-alpha and IL-6 was significantly reduced by treatment with a selective PERK inhibitor, GSK2606414, and by gene silencing against PERK and activating transcription factor 4 (ATF4) transcripts. 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine 109-119 interleukin 6 Homo sapiens 32-36 29715306-11 2018 (PTX+DEX) synergistically decreased LPS- and LPS/ATP-induced TNF, IL-1beta, and IL-6, and R848-induced IL-1beta and interferon-alpha, while (PTX+AZI) synergistically decreased induction of TNF, IL-1beta, and IL-6. Dexamethasone 5-8 interleukin 6 Homo sapiens 208-212 29571607-10 2018 Serum 25(OH)D concentration was significantly and negatively correlated with serum IL-6. 25(oh)d 6-13 interleukin 6 Homo sapiens 83-87 29571607-12 2018 We hypothesized that vitamin D might reduce the risk for TFI through suppressing the production of IL-6. Vitamin D 21-30 interleukin 6 Homo sapiens 99-103 29715306-9 2018 DEX inhibited IL-10 in newborn, and TNF, IL-1beta, IL-6 and interferon-alpha in newborn and adult blood. Dexamethasone 0-3 interleukin 6 Homo sapiens 51-55 29565447-0 2018 CAFs enhance paclitaxel resistance by inducing EMT through the IL-6/JAK2/STAT3 pathway. Paclitaxel 13-23 interleukin 6 Homo sapiens 63-67 29565447-15 2018 The expression of interstitial IL-6 in paraffin-embedded tissues was detected by immunohistochemistry. Paraffin 39-47 interleukin 6 Homo sapiens 31-35 29565447-21 2018 Univariate and multivariate analyses revealed that age, CA125, interstitial IL-6 expression and cytoreduction satisfaction were closely related to the sensitivity of the TP (docetaxel plus cisplatin or carbopatin) regimen in ovarian cancer (P<0.05). neotetrazolium 170-172 interleukin 6 Homo sapiens 76-80 29565447-22 2018 These results demonstrated that CAFs highly secreted IL-6 and promoted beta-TGF-mediated EMT in ovarian cancer via the JAK2/STAT3 pathway, leading to inhibited apoptosis and subsequent paclitaxel resistance. Paclitaxel 185-195 interleukin 6 Homo sapiens 53-57 29735470-7 2018 At the same time, the average TNF-a, IL-1 and IL-6 water in the observation group were significantly lower than that of the control group, proving that the treatment regimen could reduce the inflammatory response. Water 51-56 interleukin 6 Homo sapiens 46-50 29715306-11 2018 (PTX+DEX) synergistically decreased LPS- and LPS/ATP-induced TNF, IL-1beta, and IL-6, and R848-induced IL-1beta and interferon-alpha, while (PTX+AZI) synergistically decreased induction of TNF, IL-1beta, and IL-6. Dexamethasone 5-8 interleukin 6 Homo sapiens 80-84 29715306-11 2018 (PTX+DEX) synergistically decreased LPS- and LPS/ATP-induced TNF, IL-1beta, and IL-6, and R848-induced IL-1beta and interferon-alpha, while (PTX+AZI) synergistically decreased induction of TNF, IL-1beta, and IL-6. Adenosine Triphosphate 49-52 interleukin 6 Homo sapiens 80-84 29715306-11 2018 (PTX+DEX) synergistically decreased LPS- and LPS/ATP-induced TNF, IL-1beta, and IL-6, and R848-induced IL-1beta and interferon-alpha, while (PTX+AZI) synergistically decreased induction of TNF, IL-1beta, and IL-6. Adenosine Triphosphate 49-52 interleukin 6 Homo sapiens 208-212 29740988-6 2018 RESULTS: Contrary to high-dose ethanol, acute low-dose ethanol exposure significantly reduced IL-1beta-induced IL-6 and IL-6-induced IL-1beta release (P<0.05). Ethanol 55-62 interleukin 6 Homo sapiens 111-115 29413957-7 2018 2-ClHA and its alkyne analogue interfered with protein palmitoylation, induced ER-stress markers, reduced the ER ATP content, and activated transcription and secretion of interleukin (IL)-6 as well as IL-8. 2-chlorohexadecanoic acid 0-6 interleukin 6 Homo sapiens 171-189 29413957-9 2018 The protein kinase R-like ER kinase (PERK) inhibitor GSK2606414 suppressed 2-ClHA-mediated activating transcription factor 4 synthesis and IL-6/8 secretion, but showed no effect on endothelial barrier dysfunction and cleavage of procaspase-3. 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine 53-63 interleukin 6 Homo sapiens 139-143 29695657-6 2018 Importantly, the IL-6 gene promoter contains a single nucleotide polymorphism (SNP), -572C/G, and ICAM-1 gene contains a SNP (A/G) in the protein-coding region, Lys (AAG)/Glu (GAG) at codon 469, known as K469E polymorphism. Lysine 161-164 interleukin 6 Homo sapiens 17-21 29740988-6 2018 RESULTS: Contrary to high-dose ethanol, acute low-dose ethanol exposure significantly reduced IL-1beta-induced IL-6 and IL-6-induced IL-1beta release (P<0.05). Ethanol 55-62 interleukin 6 Homo sapiens 120-124 29731768-0 2018 TIMP3 Overexpression Improves the Sensitivity of Osteosarcoma to Cisplatin by Reducing IL-6 Production. Cisplatin 65-74 interleukin 6 Homo sapiens 87-91 29922277-9 2018 Interleukin (IL)-6 and IL-8 mRNA and protein were induced in both cell types after treatment with AMC particles, whereas exposure to CoCr particles resulted in significantly upregulated IL-6 and IL-8 protein contents in PBMCs only. 7-amino-4-methylcoumarin 98-101 interleukin 6 Homo sapiens 0-18 29850636-2 2018 Our objective was to analyze any association between the oxygen levels at blood sampling and plasma levels of the interleukins IL-6, IL-1beta, IL-10, and IL-8 and TNF-alpha in preterm newborns under mechanical ventilation (MV) in their first two days. Oxygen 57-63 interleukin 6 Homo sapiens 127-131 29850636-11 2018 In the high oxygen group, IL-6, IL-8, and TNF-alpha plasma levels increased significantly after two hours under MV. Oxygen 12-18 interleukin 6 Homo sapiens 26-30 29710775-6 2018 Targeting of TGF-&beta; signaling resulted in a strong reduction of pro-collagen-I and significantly decreased IL-6 levels. Adenosine Monophosphate 18-21 interleukin 6 Homo sapiens 115-119 29731768-16 2018 In conclusion, cisplatin sensitivity correlated positively with TIMP3 expression, which is regulated by the IL-6/TIMP3/caspase pathway. Cisplatin 15-24 interleukin 6 Homo sapiens 108-112 29682295-0 2018 Is interleukin-6 the link between low LDL cholesterol and increased non-cardiovascular mortality in the elderly? Cholesterol 42-53 interleukin 6 Homo sapiens 3-16 29540470-4 2018 Systemically, IL6 elevated the levels of circulating cholesterol by inducing host adipose lipolysis and hepatic cholesterol biosynthesis. Cholesterol 53-64 interleukin 6 Homo sapiens 14-17 29651140-0 2018 Novel Indole-fused benzo-oxazepines (IFBOs) inhibit invasion of hepatocellular carcinoma by targeting IL-6 mediated JAK2/STAT3 oncogenic signals. benzo-oxazepines 19-35 interleukin 6 Homo sapiens 102-106 29853785-8 2018 In addition, plasma interleukin-6 was higher in the saline group than in the dexmedetomidine group at postoperative day 1 [118.8 (68.8) versus 78.5 (58.8) pg.ml-1, p = 0.0271]. Sodium Chloride 52-58 interleukin 6 Homo sapiens 20-33 29633731-4 2018 IL-6 seems to play an important role in the pathogenesis of the thrombocytosis induced by ATRA. Tretinoin 90-94 interleukin 6 Homo sapiens 0-4 29558031-9 2018 IL-6 can modulate bone mineral density in the femoral neck especially in the course of CD. Cadmium 87-89 interleukin 6 Homo sapiens 0-4 29452068-5 2018 Here, we found that glycyrrhizin (20 or 40 muM) inhibited histamine-induced the mRNA expression and secretion of mucin 5 subtype AC (MUC5AC), interleukin (IL)-6 and IL-8 in HNEpCs. Histamine 58-67 interleukin 6 Homo sapiens 142-160 29581268-1 2018 In response to IFNbeta, the IL6 gene is activated, modestly at early times by ISGF3 (IRF9 plus tyrosine-phosphorylated STATs 1 and 2), and strongly at late times by U-ISGF3 (IRF9 plus U-STATs 1 and 2, lacking tyrosine phosphorylation). Tyrosine 95-103 interleukin 6 Homo sapiens 28-31 29581268-1 2018 In response to IFNbeta, the IL6 gene is activated, modestly at early times by ISGF3 (IRF9 plus tyrosine-phosphorylated STATs 1 and 2), and strongly at late times by U-ISGF3 (IRF9 plus U-STATs 1 and 2, lacking tyrosine phosphorylation). Tyrosine 209-217 interleukin 6 Homo sapiens 28-31 29617422-7 2018 Additionally, we aimed to determine the presence of anti-SAA and anti-SAA1alpha autoantibodies in intravenous immunoglobulin (IVIg) preparations and examine their effects on released IL-6 from SAA/SAA1alpha-treated peripheral blood mononuclear cells (PBMCs). saa1alpha 197-206 interleukin 6 Homo sapiens 183-187 29617422-12 2018 Both anti-SAA and anti-SAA1alpha were detected in IVIg, their fractions subsequently isolated, and shown to decrease IL-6 protein levels released from SAA/SAA1alpha-treated PBMCs. saa1alpha 23-32 interleukin 6 Homo sapiens 117-121 29529124-8 2018 Treatment of degenerated CEP cells with 17beta-estradiol (E2) increased the expressions of aggrecan and collagen II, as well as the secretion of TGF-beta, but decreased IL-6 secretion. Estradiol 40-56 interleukin 6 Homo sapiens 169-173 29357434-6 2018 We demonstrate that NEU1 and NEU3 promote IL-6 production in MES13 MCs. mes13 mcs 61-70 interleukin 6 Homo sapiens 42-46 29275510-4 2018 Exposure to 100 muM BPA had no effects on cell viability, but increased cytoplasmic expression of ERbeta and release of GDF-15, as well as decreased release of IL-6, ET-1, and IP-10 through suppression of NFkappaB phosphorylation. bisphenol A 20-23 interleukin 6 Homo sapiens 160-164 29330220-9 2018 The most striking effects of IL-6 and/or fatty acid treatment were observed in HepaRG cells after 14 days of treatment, making these cultures appear a suitable model for studying the relationship of fatty acid accumulation, inflammation, and xenobiotic-induced drug metabolism. Fatty Acids 199-209 interleukin 6 Homo sapiens 29-33 29540470-4 2018 Systemically, IL6 elevated the levels of circulating cholesterol by inducing host adipose lipolysis and hepatic cholesterol biosynthesis. Cholesterol 112-123 interleukin 6 Homo sapiens 14-17 29348049-6 2018 Herein, we discuss not only results obtained for copper(I)/(II) complexes with phosphines derived from HNr and HCp but we also compare them to previously described data for complexes with HLm and HSf derivatives. Copper 49-55 interleukin 6 Homo sapiens 196-199 29248753-0 2018 The study of vitamin D administration effect on CRP and Interleukin-6 as prognostic biomarkers of ventilator associated pneumonia. Vitamin D 13-22 interleukin 6 Homo sapiens 56-69 29248753-8 2018 CONCLUSION: Our results indicate that vitamin D administration can significantly reduce the IL-6 as prognostic marker in VAP patients, and must be considered as adjunct option in the treatment of VAP patients. Vitamin D 38-47 interleukin 6 Homo sapiens 92-96 29872728-12 2018 Collectively, these data suggest that Nox1-mediated ROS production is required for UVB-induced cytotoxicity and inflammation through p38 activation and inflammatory cytokine production, such as IL-6. Reactive Oxygen Species 52-55 interleukin 6 Homo sapiens 194-198 29445009-5 2018 In vivo and in vitro binge alcohol exposure significantly inhibited the TLR4-MyD88 cytokines TNF-alpha and IL-6, as well as the TLR4-TRIF cytokines/chemokines IFN-beta, IP-10, and RANTES, in human monocytes, but not TLR3-TRIF-induced cytokines/chemokines, as detected by quantitative PCR and ELISA. Alcohols 27-34 interleukin 6 Homo sapiens 107-111 29589999-11 2018 The IL-1beta-induced hyaluronan production and mRNA expression of IL-6, cyclooxygenase-2, and intercellular adhesion molecule-1 were also significantly suppressed after metformin or phenformin co-treatment. Metformin 169-178 interleukin 6 Homo sapiens 66-70 29588466-5 2018 Incubation with clinically-relevant concentrations of canagliflozin, but not empagliflozin or dapagliflozin activated AMPK and inhibited IL-1beta-stimulated adhesion of pro-monocytic U937 cells and secretion of IL-6 and monocyte chemoattractant protein-1 (MCP-1). Canagliflozin 54-67 interleukin 6 Homo sapiens 211-215 29796304-5 2018 Results & conclusion: Limit of detection of 1 pg/ml was achieved for CRP and IL-6 in human urine and synthetic urine buffers. Adenosine Monophosphate 9-12 interleukin 6 Homo sapiens 81-85 29567956-6 2018 These results indicate that functional lactic acid bacteria induce IL-6 and IL-10 production by dendritic cells, which contribute to upregulating the sIgA concentration at mucosal sites in humans. Lactic Acid 39-50 interleukin 6 Homo sapiens 67-71 29623201-8 2018 Immunoglobulin G, immunoglobulin A and interleukin 6 levels in the case cohort, respectively, associated weakly with fasting blood glucose (r = 0.252, p = 0.001; r = 0.170, p = 0.031; r = 0.296, p = 0.001). Glucose 131-138 interleukin 6 Homo sapiens 0-52 29309810-7 2018 These results showed that AlCl3 exposure reduced T and B lymphocyte proliferation rates, CD3+ and CD4+ T lymphocyte subpopulations, CD4+/CD8+ ratio, IL-2, IL-6 and TNF-alpha contents, SOD and GSH-Px activities, early and later lymphocyte apoptosis indexes while enhanced CD8+ T lymphocyte subpopulation, NO and MDA contents, LDH activity. Aluminum Chloride 26-31 interleukin 6 Homo sapiens 155-159 29273305-4 2018 IL-6 concentrations were significantly higher at the 3h and 6h time point after tonic-clonic seizures (TCS) compared to the situation with simple partial and complex partial seizures. Tritium 53-55 interleukin 6 Homo sapiens 0-4 28558479-3 2018 Recent Advances: Extracellular IL-6, which stimulates the release of cortisol from the zona fasciculata of the adrenal cortex, mediates its intracellular effects by tyrosine phosphorylation of the transcription factor signal transducer and activator of transcription 3 (STAT3). Tyrosine 165-173 interleukin 6 Homo sapiens 31-35 29302812-0 2018 Dexamethasone downregulates SIRT1 and IL6 and upregulates EDN1 genes in stem cells derived from gingivae via the AGE/RAGE pathway. Dexamethasone 0-13 interleukin 6 Homo sapiens 38-41 29286537-6 2018 METHODS: We explored the relationship between self-reported alcohol and cannabis use and circulating levels of the pro-inflammatory cytokines interleukin 6 (IL-6), IL-8, and IL-1beta in the blood. Alcohols 60-67 interleukin 6 Homo sapiens 142-155 29286537-6 2018 METHODS: We explored the relationship between self-reported alcohol and cannabis use and circulating levels of the pro-inflammatory cytokines interleukin 6 (IL-6), IL-8, and IL-1beta in the blood. Alcohols 60-67 interleukin 6 Homo sapiens 157-161 29286537-9 2018 RESULTS: A positive association between alcohol and IL-6 emerged. Alcohols 40-47 interleukin 6 Homo sapiens 52-56 29286537-11 2018 Follow-up moderation analyses indicated a cannabis by alcohol interaction predicting circulating IL-6, such that cannabis nonusers showed a stronger relationship between alcohol and IL-6 compared to cannabis users. Alcohols 54-61 interleukin 6 Homo sapiens 97-101 29286537-11 2018 Follow-up moderation analyses indicated a cannabis by alcohol interaction predicting circulating IL-6, such that cannabis nonusers showed a stronger relationship between alcohol and IL-6 compared to cannabis users. Alcohols 54-61 interleukin 6 Homo sapiens 182-186 29286537-11 2018 Follow-up moderation analyses indicated a cannabis by alcohol interaction predicting circulating IL-6, such that cannabis nonusers showed a stronger relationship between alcohol and IL-6 compared to cannabis users. Alcohols 170-177 interleukin 6 Homo sapiens 97-101 29286537-11 2018 Follow-up moderation analyses indicated a cannabis by alcohol interaction predicting circulating IL-6, such that cannabis nonusers showed a stronger relationship between alcohol and IL-6 compared to cannabis users. Alcohols 170-177 interleukin 6 Homo sapiens 182-186 29710474-0 2018 Resveratrol inhibits Interleukin-6 induced invasion of human gastric cancer cells. Resveratrol 0-11 interleukin 6 Homo sapiens 21-34 29710474-6 2018 In gastric cancer cell line model, we found that non-cytotoxic concentration of resveratrol inhibited the Interleukin-6 induced SGC7901 cell invasion and matrix metalloproteinases activation. Resveratrol 80-91 interleukin 6 Homo sapiens 106-119 29710474-7 2018 Our studies showed that IL-6 induced SGC7901 cell invasion depends on the Raf/MAPK pathway activation, resveratrol could inhibit this pathway activation. Resveratrol 103-114 interleukin 6 Homo sapiens 24-28 29710474-8 2018 We further showed that resveratrol inhibits the IL-6 induced metastasis by vein injection of luciferase-labeled cancer cells. Resveratrol 23-34 interleukin 6 Homo sapiens 48-52 29710474-9 2018 In conclusion, these results indicate that Interleukin-6 promotes tumor growth and metastasis in gastric cancer, resveratrol has the potential to prevent the Interleukin-6 induced gastric cancer metastasis by blocking the Raf/MAPK signaling activation. Resveratrol 113-124 interleukin 6 Homo sapiens 158-171 33418784-7 2018 In contrast to class C CpG ODNs, which also simultaneously induce IFN-alpha and IL-6, the ratio of IFN-alpha and IL-6 induced by PEI-CpG ODN NPs could be regulated by changing the N/P ratio. Nitrogen 29-30 interleukin 6 Homo sapiens 80-84 29183872-7 2018 Multivariate analysis revealed a significant, negative correlation between serum IL-6 and free testosterone. Testosterone 95-107 interleukin 6 Homo sapiens 81-85 29222745-0 2018 MiR-26a functions as a tumor suppressor in ambient particulate matter-bound metal-triggered lung cancer cell metastasis by targeting LIN28B-IL6-STAT3 axis. Metals 76-81 interleukin 6 Homo sapiens 140-143 29302812-2 2018 RESULTS: Four mRNAs were upregulated and 12 were downregulated when the results of dexamethasone at 24 h were compared with the control at 24 h. Expressions of SIRT1 and IL6 were decreased in dexamethasone at 24 h but expression of EDN1 was increased. Dexamethasone 192-205 interleukin 6 Homo sapiens 170-173 29302812-3 2018 CONCLUSIONS: Application of dexamethasone reduced the expression of SIRT1 and IL6 but enhanced the expression of EDN1 of stem cells. Dexamethasone 28-41 interleukin 6 Homo sapiens 78-81 29302812-2 2018 RESULTS: Four mRNAs were upregulated and 12 were downregulated when the results of dexamethasone at 24 h were compared with the control at 24 h. Expressions of SIRT1 and IL6 were decreased in dexamethasone at 24 h but expression of EDN1 was increased. Dexamethasone 83-96 interleukin 6 Homo sapiens 170-173 29223817-11 2018 IL-6 was associated negatively with systolic blood pressure, pulse pressure and HDL, and positively associated with TG, Tc/HDL and LDL/HDL. Triglycerides 116-118 interleukin 6 Homo sapiens 0-4 29456111-2 2018 Methyllucidone inhibited STAT3 phosphorylation at tyrosine 705 in a dose- and time dependent manner in DU145 prostate cancer cells and suppressed IL-6-induced STAT3 phosphorylation at Tyr-705 in LNCaP cells. Tyrosine 50-58 interleukin 6 Homo sapiens 146-150 29456111-2 2018 Methyllucidone inhibited STAT3 phosphorylation at tyrosine 705 in a dose- and time dependent manner in DU145 prostate cancer cells and suppressed IL-6-induced STAT3 phosphorylation at Tyr-705 in LNCaP cells. Tyrosine 184-187 interleukin 6 Homo sapiens 146-150 29324259-9 2018 RESULTS: Higher serum vitamin D levels positively correlated with higher ratios of IL-4 + IL-10/IL-17A + TNF-alpha (r = 0.37, P < .01), and IL-4 + IL-10/IL-6 + TNF-alpha (r = 0.32, P < .01). Vitamin D 22-31 interleukin 6 Homo sapiens 156-160 29248584-8 2018 Cells treated with dexamethasone alone at both the concentrations inhibit the mRNAs expression of IL-1beta, IL-6 and TNF-alpha compared to control. Dexamethasone 19-32 interleukin 6 Homo sapiens 108-112 29092903-5 2018 GPR68 activation (by decreasing the extracellular pH) enhanced IL-6 expression via a cAMP/PKA/cAMP response element binding protein signaling pathway. Cyclic AMP 85-89 interleukin 6 Homo sapiens 63-67 29092903-5 2018 GPR68 activation (by decreasing the extracellular pH) enhanced IL-6 expression via a cAMP/PKA/cAMP response element binding protein signaling pathway. Cyclic AMP 94-98 interleukin 6 Homo sapiens 63-67 29773098-9 2018 Pre-treatment with EX-527 attenuated the inhibitory effects of polydatin on the proliferation of MDMs, inhibited the expressions of SIRT1, promoted the expressions of MCP-1, TNF-alpha and IL-6. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 19-25 interleukin 6 Homo sapiens 188-192 28647788-11 2018 CONCLUSIONS: The administration of two low-dose peri-operative dexamethasone can effectively reduce the post-operative level of CRP and IL-6, provide additional pain and nausea control, ameliorate post-operative fatigue, enhance mobility, and shorten post-operative LOS following THA, without increasing the risk of infection and gastrointestinal hemorrhage. Dexamethasone 63-76 interleukin 6 Homo sapiens 136-140 29318480-4 2018 The results indicated that rosmarinic acid reduced the expression of CD11b, a marker of microglia and macrophages, in the brain and dramatically inhibited the levels of inflammatory cytokines and mediators, such as TNFalpha, IL-6, IL-1beta, COX-2, and iNOS, in a dose-dependent manner both in vitro and in vivo. rosmarinic acid 27-42 interleukin 6 Homo sapiens 225-229 29275851-5 2018 Alkaline phosphatase activity of the osteoblast-like cells was significantly increased (P < .05) by CPP-ACP and CPP-ACFP, as was the production of the osteotropic cytokine IL-6, the formation of calcium mineral deposits, and the secretion of mineralization-related proteins (collagen type I and osteocalcin). Calcium 198-205 interleukin 6 Homo sapiens 175-179 29275476-8 2018 Furthermore, lignosulfonic acid decreased the TNF-alpha- and IFN-gamma-induced increase in interleukin (IL)-1beta and IL-6 expression in Caco-2 cells. LIGNOSULFONIC ACID 13-31 interleukin 6 Homo sapiens 118-122 28765037-0 2018 Vitamin D effects on monocytes" CCL-2, IL6 and CD14 transcription in Addison"s disease and HLA susceptibility. Vitamin D 0-9 interleukin 6 Homo sapiens 39-42 29155016-3 2018 In this report, we demonstrated that in vitro, DZ2002 significantly decreased the expression of pro-inflammatory cytokines and adhesion molecule including IL-1alpha, IL-1beta, IL-6, IL-8, TNF-alpha and ICAM-1 by inhibiting the phosphorylation of p38 MAPK, ERK and JNK in TNF-alpha/IFN-gamma-stimulated HaCaT human keratinocytes. methyl 4-(adenin-9-yl)-2-hydroxybutanoate 47-53 interleukin 6 Homo sapiens 176-180 29486738-10 2018 IL-6, IL-8 and XIAP showed increased expressions in PTX-treated cells and this over-production effect was inhibited in TLR4-transient knockdown cells. Paclitaxel 52-55 interleukin 6 Homo sapiens 0-4 29486738-14 2018 CONCLUSIONS: The acquired TLR4-mediated PTX resistance in BCA and melanoma is explained partly by the paracrine effect of IL-6 and IL-8 released into the tumor microenvironment and over-production of anti-apoptotic protein, XIAP, in BCA cells and importantly CpdA could reduce this effect and sensitize PTX-induced apoptosis in a synergistic manner. Paclitaxel 40-43 interleukin 6 Homo sapiens 122-126 29486738-14 2018 CONCLUSIONS: The acquired TLR4-mediated PTX resistance in BCA and melanoma is explained partly by the paracrine effect of IL-6 and IL-8 released into the tumor microenvironment and over-production of anti-apoptotic protein, XIAP, in BCA cells and importantly CpdA could reduce this effect and sensitize PTX-induced apoptosis in a synergistic manner. Paclitaxel 303-306 interleukin 6 Homo sapiens 122-126 29281056-3 2018 Melatonin priming improves plant tolerance to cold, heat, salt, and drought stresses through regulation of genes involved in the DREB/CBF, HSF, SOS, and ABA pathways, respectively. Melatonin 0-9 interleukin 6 Homo sapiens 139-142 29059160-6 2018 In clinical samples, ESCC patients with high expression of CXCR7 and IL6 presented a significantly worse overall survival and progression-free survival upon receiving cisplatin after operation. Cisplatin 167-176 interleukin 6 Homo sapiens 69-72 29471853-14 2018 Moreover, HBXIP was able to act as a co-activator of HOXB13 to stimulate interleukin (IL)-6 transcription in the promotion of TAM resistance. Tamoxifen 126-129 interleukin 6 Homo sapiens 73-91 29434184-9 2018 CsA significantly increased the mRNA expressions of the calcification markers (core binding factor-alpha 1, bone morphologic proteins 2) as well as those of the inflammatory marker (interleukin 6), under HG with a calcifying medium. Cyclosporine 0-3 interleukin 6 Homo sapiens 182-195 29402921-4 2018 Piglets fed the lysine-restricted diet exhibited overexpression of interleukin-8 (IL-8) in the kidney (P < 0.05) and IL-6 and IL-4 in the spleen (P < 0.05). Lysine 16-22 interleukin 6 Homo sapiens 120-124 29106440-9 2018 In vitro, these cytokines increased MSI in colon epithelial cells, and the Janus kinase (JAK) inhibitor tofacitinib abolished IL-6-induced or PMN-induced MSI. tofacitinib 104-115 interleukin 6 Homo sapiens 126-130 29456509-7 2018 Moreover inhibition of STAT3 pathways by curcumin increased FOXA2 expression in NCI-H292 cells whereas a STAT3 activator (IL-6) significantly inhibited curcumin-induced FOXA2 expression. Curcumin 152-160 interleukin 6 Homo sapiens 122-126 29358506-10 2018 Moreover, TA was effective in inhibiting nuclear factor-kappa B (NF-kappaB) phosphorylation and suppressing the expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). tubastatin A 10-12 interleukin 6 Homo sapiens 170-183 29358506-10 2018 Moreover, TA was effective in inhibiting nuclear factor-kappa B (NF-kappaB) phosphorylation and suppressing the expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). tubastatin A 10-12 interleukin 6 Homo sapiens 185-189 28834248-8 2018 While our molecular analysis revealed several training effects, the only group interaction (P < 0.0001) arose from a downregulated mRNA expression of IL-6 in IBU. Ibuprofen 161-164 interleukin 6 Homo sapiens 153-157 32153865-11 2018 Conclusions: This study provided evidence that vitamin D supplementation had no impact on serum CRP, IL10, and TNF-alpha, while significantly increased serum IL6. Vitamin D 47-56 interleukin 6 Homo sapiens 158-161 29216514-5 2018 The 50% Herceptin -NP conjugate group with short PEG modification to Herceptin showed the best reduction in immune cell uptake by 82% along with the reduction by >50% for proinflammatory cytokine response (TNF-alpha and IL-6). Polyethylene Glycols 49-52 interleukin 6 Homo sapiens 224-228 28927890-5 2018 Tofacitinib and etanercept commonly reduced IL-6, CCL20, and CXCL10, but IL-17A was significantly reduced only in responders of either treatment. tofacitinib 0-11 interleukin 6 Homo sapiens 44-48 29061842-0 2018 Endothelial nitric oxide synthase modulates Toll-like receptor 4-mediated IL-6 production and permeability via nitric oxide-independent signaling. Nitric Oxide 12-24 interleukin 6 Homo sapiens 74-78 29236553-5 2018 lipopolysaccharide co-treatment with progesterone significantly decreased the bacterial endotoxin-induced IL-1beta, TNF-alpha, IL-6, IL-8, and MIP-1alpha secretion. Progesterone 37-49 interleukin 6 Homo sapiens 127-131 28600879-10 2018 After N-acetyl cysteine treatment ROS level was partly abolished providing additional enhancement of IL-6 and suppression of IL-8 and VEGF production. Acetylcysteine 6-23 interleukin 6 Homo sapiens 101-105 28600879-10 2018 After N-acetyl cysteine treatment ROS level was partly abolished providing additional enhancement of IL-6 and suppression of IL-8 and VEGF production. ros 34-37 interleukin 6 Homo sapiens 101-105 29175901-6 2018 Before LAGB, IL-6 correlated negatively with iron, hemoglobin concentration and MCHC; hepcidin correlated inversely with transferrin. Iron 45-49 interleukin 6 Homo sapiens 13-17 29162613-7 2018 By contrast, ruxolitinib failed to suppress the repression of drug-detoxifying protein mRNA levels caused by IL-1beta The JAK inhibitor and anti-rheumatoid arthritis compound tofacitinib was additionally found to reverse IL-6-mediated suppression of P450 and transporter mRNA expressions. tofacitinib 175-186 interleukin 6 Homo sapiens 221-225 28852907-7 2018 HK-2 cells with high glucose up-regulated IL-6 and MCP-1 in a dose- and time-dependent manner, and SUV39H1 expression was reduced with greater glucose and prolonged stimulation. Glucose 21-28 interleukin 6 Homo sapiens 42-46 29260441-11 2018 IL-6 and IL-18 expression in the striatum was significantly higher in the HIV-1Tg EtOH group than in the F344 EtOH group. Ethanol 82-86 interleukin 6 Homo sapiens 0-4 29175901-7 2018 Our data show that 13 months after LAGB, the weight loss is associated with an improvement in inflammation, namely a reduction in IL-6 that may reduce hepcidin production, improving iron availability for erythropoiesis, as shown by more adequate erythrocyte hemoglobinization. Iron 182-186 interleukin 6 Homo sapiens 130-134 29260441-11 2018 IL-6 and IL-18 expression in the striatum was significantly higher in the HIV-1Tg EtOH group than in the F344 EtOH group. Ethanol 110-114 interleukin 6 Homo sapiens 0-4 29260441-12 2018 DHA significantly decreased the high levels of IL-6, IL-18, and NF-kappaB expression observed in the HIV-1Tg EtOH group. Ethanol 109-113 interleukin 6 Homo sapiens 47-51 29348392-5 2018 Rapamycin treatment decreased the gene expression of MMP-3, MMP-13, IL-1beta, IL-6, TNF-alpha, and protein levels of P16 and P21 in bleomycin-treated AFSCs. Sirolimus 0-9 interleukin 6 Homo sapiens 78-82 29309791-3 2018 Streptozotocin (STZ)-induced type 2 DM is used as a model of human type 2 DM in which peripheral insulin resistance, increased plasma interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) and hyperglycemia occurs. Streptozocin 0-14 interleukin 6 Homo sapiens 134-147 29309791-3 2018 Streptozotocin (STZ)-induced type 2 DM is used as a model of human type 2 DM in which peripheral insulin resistance, increased plasma interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) and hyperglycemia occurs. Streptozocin 0-14 interleukin 6 Homo sapiens 149-153 29309791-3 2018 Streptozotocin (STZ)-induced type 2 DM is used as a model of human type 2 DM in which peripheral insulin resistance, increased plasma interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) and hyperglycemia occurs. Streptozocin 16-19 interleukin 6 Homo sapiens 134-147 29309791-3 2018 Streptozotocin (STZ)-induced type 2 DM is used as a model of human type 2 DM in which peripheral insulin resistance, increased plasma interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) and hyperglycemia occurs. Streptozocin 16-19 interleukin 6 Homo sapiens 149-153 29385086-0 2018 Spiroketones and a Biphenyl Analog from Stems and Leaves of Larrea nitida and Their Inhibitory Activity against IL-6 Production. spiroketones 0-12 interleukin 6 Homo sapiens 112-116 29113965-8 2018 The increased mitochondrial reactive oxygen species levels of atherosclerotic-MSCs promoted a phenotypic switch characterized by enhanced glycolysis and an altered cytokine secretion (interleukin-6 P<0.0001, interleukin-8/C-X-C motif chemokine ligand 8 P=0.04, and monocyte chemoattractant protein-1/chemokine ligand 2 P=0.01). Reactive Oxygen Species 28-51 interleukin 6 Homo sapiens 184-197 29113965-9 2018 Furthermore, treatment of atherosclerotic-MSCs with the reactive oxygen species scavenger N-acetyl-l-cysteine reduced the levels of interleukin-6, interleukin-8/C-X-C motif chemokine ligand 8, and monocyte chemoattractant protein-1/chemokine ligand 2 in the MSC secretome and improved MSCs immunosuppressive capacity (P=0.03). Reactive Oxygen Species 56-79 interleukin 6 Homo sapiens 132-145 29113965-9 2018 Furthermore, treatment of atherosclerotic-MSCs with the reactive oxygen species scavenger N-acetyl-l-cysteine reduced the levels of interleukin-6, interleukin-8/C-X-C motif chemokine ligand 8, and monocyte chemoattractant protein-1/chemokine ligand 2 in the MSC secretome and improved MSCs immunosuppressive capacity (P=0.03). Acetylcysteine 90-109 interleukin 6 Homo sapiens 132-145 29568569-5 2018 Results: One such material, synthesized from chondroitin sulfate type A and serotonin in the presence of Cu2+ was found to affect the release of IL-1beta and IL-6 cytokines from immune cells. Serotonin 76-85 interleukin 6 Homo sapiens 158-162 29484258-9 2018 Results: Serum vitamin D levels were negatively correlated with serum levels of interleukin-6 and high-sensitivity C-reactive protein (hsCRP) (r = -.244, p = .002; r = -.231, p = .004). Vitamin D 15-24 interleukin 6 Homo sapiens 80-93 29128404-10 2018 No differences in ZO-1 relative expression patterns were observed in cultured cells, with increased expression in IL-6 in cells exposed to nTg milk than controls, with the Tg group being similar to all groups. Thioguanine 140-142 interleukin 6 Homo sapiens 114-118 28962868-9 2018 HaCaT cells pretreated/treated with FITOPROT also showed normal expression of TNF-R1 and NF-kappaB inflammatory proteins and decreased levels of pro-inflammatory cytokines (TNF, IL-1beta, IL-6 and IL-8). fitoprot 36-44 interleukin 6 Homo sapiens 188-192 29484258-10 2018 Multiple regression analysis showed that interleukin-6 and hsCRP levels were associated with vitamin D levels (B = -0.355, p = .003; B = -2.085, p = .006), whereas age, height, weight, leukocyte count, neutrophil ratio, and lymphocyte rate could be omitted without changing the results. Vitamin D 93-102 interleukin 6 Homo sapiens 41-54 29484258-12 2018 Conclusions: Serum vitamin D levels are inversely associated with the levels of interleukin-6 and hsCRP, suggesting a potential anti-inflammatory role for vitamin D in stroke individuals. Vitamin D 19-28 interleukin 6 Homo sapiens 80-93 28328292-0 2018 IL-6 is involved in malignancy and doxorubicin sensitivity of renal carcinoma cells. Doxorubicin 35-46 interleukin 6 Homo sapiens 0-4 28328292-3 2018 The inhibition of IL-6 by siRNA can suppress the proliferation, migration and invasion of RCC cells and increase the doxorubicin (Dox) sensitivity. Doxorubicin 117-128 interleukin 6 Homo sapiens 18-22 28328292-3 2018 The inhibition of IL-6 by siRNA can suppress the proliferation, migration and invasion of RCC cells and increase the doxorubicin (Dox) sensitivity. Doxorubicin 130-133 interleukin 6 Homo sapiens 18-22 28328292-4 2018 While recombination IL-6 can attenuate the inhibition effects of Dox on proliferation of RCC cells. Doxorubicin 65-68 interleukin 6 Homo sapiens 20-24 28328292-6 2018 Over expression of STAT3 increased the proliferation, migration and invasion of RCC cells and reversed si-IL-6 induced increase of Dox sensitivity of ACHN and A498 cells. Doxorubicin 131-134 interleukin 6 Homo sapiens 106-110 28328292-8 2018 PD98059, the ERK1/2 inhibitor, attenuated IL-6 induced proliferation and synergistically increased the Dox sensitivity of si-IL-6 transfected ACHN cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 interleukin 6 Homo sapiens 42-46 28328292-8 2018 PD98059, the ERK1/2 inhibitor, attenuated IL-6 induced proliferation and synergistically increased the Dox sensitivity of si-IL-6 transfected ACHN cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 interleukin 6 Homo sapiens 125-129 28328292-8 2018 PD98059, the ERK1/2 inhibitor, attenuated IL-6 induced proliferation and synergistically increased the Dox sensitivity of si-IL-6 transfected ACHN cells. Doxorubicin 103-106 interleukin 6 Homo sapiens 125-129 28328292-9 2018 Collectively, our data suggested that IL-6 plays an important role in malignancy and Dox sensitivity of RCC. Doxorubicin 85-88 interleukin 6 Homo sapiens 38-42 29235375-3 2018 Through the modulation of generation of ROS, it promoted the synthesis and secretion of IL-6 in vascular endothelial cell (VEC), suggesting its potential proinflammatory activation. Reactive Oxygen Species 40-43 interleukin 6 Homo sapiens 88-92 29521042-10 2018 Additional application of dexamethasone to SCP-1 cells further increased the RANKL/OPG ratio 3-fold, but decreased IL-6 and IL-1beta expression to 10% and 50%, respectively. Dexamethasone 26-39 interleukin 6 Homo sapiens 115-119 29217270-6 2018 Kafirin at 100 mug/mL reduced the production of pro-inflammatory cytokines IL-1beta, IL-6 and TNF-alpha by 28.3%, 74.0%, and 81.4%, respectively. kafirin 0-7 interleukin 6 Homo sapiens 85-89 29793316-5 2018 mRNA and proteins levels of TNF-alpha and IL-6, as well as MDA level in LO2 cells treated with BPA were decreased by curcumin. Curcumin 117-125 interleukin 6 Homo sapiens 42-46 30345773-9 2018 In a multiple linear regression analysis among variables log IL-6 and log HDL cholesterol were most significantly related to ABI (LW 4.75 for log IL-6, LW 4.016 for log HDL cholesterol, respectively, p < 0.01) in all subjects. Cholesterol 78-89 interleukin 6 Homo sapiens 146-150 30345773-9 2018 In a multiple linear regression analysis among variables log IL-6 and log HDL cholesterol were most significantly related to ABI (LW 4.75 for log IL-6, LW 4.016 for log HDL cholesterol, respectively, p < 0.01) in all subjects. Cholesterol 173-184 interleukin 6 Homo sapiens 61-65 29587265-8 2018 Implications of ATP release were measured through immunoblot analysis of interleukin 6 (IL-6) and fibronectin expression. Adenosine Triphosphate 16-19 interleukin 6 Homo sapiens 73-86 29587265-8 2018 Implications of ATP release were measured through immunoblot analysis of interleukin 6 (IL-6) and fibronectin expression. Adenosine Triphosphate 16-19 interleukin 6 Homo sapiens 88-92 29938621-2 2018 Curcumin and omega-3 fatty acids can exert neuroprotective effects through modulation of IL-6 gene expression and CRP levels. Curcumin 0-8 interleukin 6 Homo sapiens 89-93 29938621-3 2018 The aim of present study is the evaluation of combined effects of omega-3 fatty acids and nano-curcumin supplementation on IL-6 gene expression and serum level and hs-CRP levels in migraine patients. Curcumin 95-103 interleukin 6 Homo sapiens 123-127 30160128-7 2018 In CD we observed a significant positive correlation of serum concentration 25(OH)VD and the expression mRNA level of IL-6. Cadmium 3-5 interleukin 6 Homo sapiens 118-122 30355931-12 2018 CONCLUSION: The paclitaxel+hirudin compound promotes MyD88 degradation in the TLR4/MyD88/NF-kappaB pathway to reduce the activity of TLR4 and NF-kappaB p65 and to weaken the LPS-initiated inflammatory reactions of IL-1beta, IL-6, and TNF-alpha. Paclitaxel 16-26 interleukin 6 Homo sapiens 224-228 28812210-14 2018 In conclusion, IL-34-stimulated THP-1 can produce higher levels of ROS, which promoted IL-6 secretion and up-regulated Th17 cells. ros 67-70 interleukin 6 Homo sapiens 87-91 29186698-9 2018 In addition, atorvastatin dose-dependently decreased basal and status epilepticus-induced levels of interleukin-1beta (IL-1beta), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (INF-gamma) and increased interleukin-10 (IL-10) levels in the hippocampus and cerebral cortex. Atorvastatin 13-25 interleukin 6 Homo sapiens 130-143 29186698-9 2018 In addition, atorvastatin dose-dependently decreased basal and status epilepticus-induced levels of interleukin-1beta (IL-1beta), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (INF-gamma) and increased interleukin-10 (IL-10) levels in the hippocampus and cerebral cortex. Atorvastatin 13-25 interleukin 6 Homo sapiens 145-149 29424905-11 2018 The level of serum E2 in the experimental group was positively correlated with the levels of IL-1, IL-6 and TNF-alpha in synovial fluid (p<0.05). Estradiol 19-21 interleukin 6 Homo sapiens 99-103 29161660-7 2018 In addition, pretreatment with AST2017-01 or chrysophanol significantly decreased the PMACI-induced levels of interleukin (IL)-1beta, IL-6, tumor necrosis factor-alpha, and thymic stromal lymphopoietin (TSLP) on HMC-1 cells. pmaci 86-91 interleukin 6 Homo sapiens 134-138 29727764-6 2018 RESULTS: Serum IL-6 was significantly higher in patients with depressive symptoms compared to normal (20.47 +- 4.27 pg/mL for HADS-D >=11 versus 9.26 +- 1.59 pg/mL for HADS-D <7, p = 0.014). hads-d < 171-181 interleukin 6 Homo sapiens 15-19 29398016-15 2018 The allergens (Der p2 and Der p3)-induced IL-6/IL-8 expression and NCA released from Beas-2B could be downregulated by dexamethasone and transcription factor inhibitor SP600125. Dexamethasone 119-132 interleukin 6 Homo sapiens 42-46 29148173-6 2018 We found that metformin ameliorated the induction of colitis and reduced the levels of pro-inflammatory cytokines IL-6, TNF-a and IL-1beta. Metformin 14-23 interleukin 6 Homo sapiens 114-118 31938083-0 2018 Synergistic effect of estradiol and testosterone protects against IL-6-inducedcardiomyocyte apoptosismediated by TGF-beta1. Estradiol 22-31 interleukin 6 Homo sapiens 66-70 31938083-0 2018 Synergistic effect of estradiol and testosterone protects against IL-6-inducedcardiomyocyte apoptosismediated by TGF-beta1. Testosterone 36-48 interleukin 6 Homo sapiens 66-70 30589029-3 2018 We hypothesized that DEX could reduce the incidence of POCD caused by sevoflurane anesthesia through decreasing plasma interleukin (IL-6) and tumor necrosis factor (TNF)-alpha concentrations. Sevoflurane 70-81 interleukin 6 Homo sapiens 132-136 30589029-10 2018 Conclusion: The POCD incidence was higher in elderly patients receiving sevoflurane anesthesia and DEX could alleviate POCD in these patients through decreasing plasma TNF-alpha and IL-6 concentrations. Sevoflurane 72-83 interleukin 6 Homo sapiens 182-186 28881473-0 2018 The classic signalling and trans-signalling of interleukin-6 are both injurious in podocyte under high glucose exposure. Glucose 103-110 interleukin 6 Homo sapiens 47-60 29466169-8 2018 Combined treatment with MEB and IV iron was associated with positive dynamics of Hb, Ht, levels of ferritin, EPO, NT-proBNP, and IL-6. Iron 35-39 interleukin 6 Homo sapiens 129-133 30071128-7 2018 Inflammation factors, such as matrix metallopeptidase 13 (Mmp13), tissue inhibitor of metalloproteinase 1 (Timp1), and interleukin-6 (Il6), were downregulated in the H2 O2 group with AP, demonstrating a decrease in the progression of OA. Hydrogen Peroxide 166-171 interleukin 6 Homo sapiens 119-132 30071128-7 2018 Inflammation factors, such as matrix metallopeptidase 13 (Mmp13), tissue inhibitor of metalloproteinase 1 (Timp1), and interleukin-6 (Il6), were downregulated in the H2 O2 group with AP, demonstrating a decrease in the progression of OA. Hydrogen Peroxide 166-171 interleukin 6 Homo sapiens 134-137 27943665-13 2018 There was a statistical significant decrease in pro-inflammatory interleukin-6 and -8 induced by the bacteria (to model the wound environment) in AMSC in the presence of timolol compared with control (p < 0.5). Timolol 170-177 interleukin 6 Homo sapiens 65-85 28992224-13 2018 As a complementary finding, treatment with HCO and MCO in vitro dialysates induced a pro-inflammatory response of the cells as demonstrated by elevated messenger RNA expression of tumour necrosis factor alpha and interleukin-6, as well as upregulation of ACE and decreased levels of ACE2. mco 51-54 interleukin 6 Homo sapiens 213-226 29051319-7 2018 When LoVo-P and HT29-C cells were cocultured with TAMs, CCL26 binding to the CCR3 receptor enhanced the invasiveness of LoVo-P and HT29-C cells by mobilizing intracellular Ca2+of TAMs to increase the expression of IL6 and IL8. Tamoxifen 50-54 interleukin 6 Homo sapiens 214-217 29051319-7 2018 When LoVo-P and HT29-C cells were cocultured with TAMs, CCL26 binding to the CCR3 receptor enhanced the invasiveness of LoVo-P and HT29-C cells by mobilizing intracellular Ca2+of TAMs to increase the expression of IL6 and IL8. lovo-p 5-11 interleukin 6 Homo sapiens 214-217 27966076-8 2018 Besides, vitamin D intake, through the proliferation decrement of pro-inflammatory cells, decreases of pro-inflammatory markers (IL-6, TNF-alpha, INF-gamma) and auto-immune pathways have potential role in recovery of irregular menstruation in women with the low level of testosterone as a red warning factor of MS development. Vitamin D 9-18 interleukin 6 Homo sapiens 129-133 29115635-10 2018 Similarly, challenging cells with either IL-6 or leptin markedly elevated the level of secreted hepcidin (p=0.05) and this was associated with an induction in colonocyte iron levels in both cases. Iron 170-174 interleukin 6 Homo sapiens 41-45 31453236-4 2017 Here, we describe how to measure the cell surface expression of recombinant IL-6-HaloTag -odorant receptors in HEK-293 cells or NxG 108CC15 cells, by live-cell staining and flow cytometry, and how to measure an odorant-induced activation of these receptors by the fast, real-time, luminescence-based GloSensor cAMP assay. Cyclic AMP 311-315 interleukin 6 Homo sapiens 76-80 30029729-7 2018 The in vitro inhibition of IL-6 secretion in hMSCs by DHEA was more consistent and extensive than by estradiol or dihydrotestosterone. Estradiol 101-110 interleukin 6 Homo sapiens 27-31 29258201-4 2017 Supplementation of the culture medium with particular fatty acids was found to have a promoting effect on cellular production of the cytokines IL-6, IL-8, GM-CSF, and MCP-1. Fatty Acids 54-65 interleukin 6 Homo sapiens 143-147 29228978-13 2017 Increased secretion of TNFalpha and IL-6 was inhibited in METH-stimulated neuronal cells by AA administration. Methamphetamine 58-62 interleukin 6 Homo sapiens 36-40 29140074-6 2017 Additionally, liposomal dexamethasone reduced proinflammatory mediator expression (particularly IL-6 and TNF-alpha) in lipopolysaccharide-stimulated human gingival fibroblasts and human mesenchymal stem cells. Dexamethasone 24-37 interleukin 6 Homo sapiens 96-100 29479468-5 2018 Conclusions: Findings in this study support the anti-inflammatory, anti-obesity and glucose homeostatic roles of IL6 in Mexican-American youth. Glucose 84-91 interleukin 6 Homo sapiens 113-116 29039587-12 2017 RA also inhibited nuclear factor (NF)-kappaB transcriptional activity and the expression of NF-kappaB target genes, including tumor necrosis factor-alpha and interleukin-6, in H2O2-exposed NHDFs. Hydrogen Peroxide 176-180 interleukin 6 Homo sapiens 158-171 29340073-6 2017 YM155 abrogated the interleukin-6-induced STAT3 phosphorylation, subsequently blocked Mcl-1 expression and induced apoptosis in MM cells. YM 155 0-5 interleukin 6 Homo sapiens 20-33 29415833-0 2017 Short-term l-arginine supplementation attenuates elevation of interleukin 6 level after resistance exercise in overweight men. Arginine 11-21 interleukin 6 Homo sapiens 62-75 29415833-10 2017 IL-6 levels increased significantly after exercise in the placebo group compared with the l-arg group (P < 0.05). Arginine 90-95 interleukin 6 Homo sapiens 0-4 29415833-12 2017 The IL-6/IL-10 ratio showed a statistically significant increase in the placebo group after exercise compared to the l-arg group (P < 0.05). Arginine 117-122 interleukin 6 Homo sapiens 4-8 29272001-13 2017 After the intervention of PGE2 and Butaprost, great increases were seen in the cell proliferation rate, invasion capability, and the expression of MMP-9, VEGF, IL-6, and TNF-alpha in EC109 and TE-1 cell strains (p < 0.05), however, the intervention of RNAi could reduce above indexes (p < 0.05). Dinoprostone 26-30 interleukin 6 Homo sapiens 160-164 31966519-5 2017 The results showed that H2O2 inhibited cell proliferation, induced cell apoptosis, IL-6 and TNFalpha release, the increase of caspase-3 protein and the decrease of Bcl-2, while transfection with S10012A shRNA significantly repaired the situation above. Water 24-28 interleukin 6 Homo sapiens 83-87 28704260-6 2017 In vitro, we demonstrated, using cultured human PASMC from PAH patients, that alpha-solanine reversed dysfunctional AXIN2, beta-catenin and bone morphogenetic protein receptor type-2 signaling, whereas restored [Ca]i, IL-6 and IL-8, contributing to the decrease of PAH-PASMC proliferation and resistance to apoptosis. alpha-solanine 78-92 interleukin 6 Homo sapiens 218-222 29087023-3 2017 Rank correlation analysis revealed that interleukin 6 expression exhibited significant positive correlations with urinary sodium (R = .13) and sodium to potassium ratio (R = .13). Sodium 122-128 interleukin 6 Homo sapiens 40-53 29087023-3 2017 Rank correlation analysis revealed that interleukin 6 expression exhibited significant positive correlations with urinary sodium (R = .13) and sodium to potassium ratio (R = .13). Sodium 143-149 interleukin 6 Homo sapiens 40-53 29087023-5 2017 The study suggests that a high-salt diet may lead to increased interleukin 6 levels and may contribute to hypertension. Salts 31-35 interleukin 6 Homo sapiens 63-76 30647695-9 2017 On the other hand, Se and GLY reduced hydrogen peroxide-mediated production of TNF-alpha, IL-1, IL-6 and expression of iNOS and NF-kappaB. Glycine 26-29 interleukin 6 Homo sapiens 96-100 30647695-9 2017 On the other hand, Se and GLY reduced hydrogen peroxide-mediated production of TNF-alpha, IL-1, IL-6 and expression of iNOS and NF-kappaB. Hydrogen Peroxide 38-55 interleukin 6 Homo sapiens 96-100 29115971-7 2017 However, local anaesthetics alone or in combination with morphine and/or MgSO4 reduced cell viability and increased the gene expression of IL-1beta, IL-6 or TNF-alpha. Morphine 57-65 interleukin 6 Homo sapiens 149-153 28242869-8 2017 Peripheral monocyte response to lipopolysaccharide stimulation was lower in alcohol-dependent subjects compared with controls for the proinflammatory cytokines interleukin-6 and interleukin-8. Alcohols 76-83 interleukin 6 Homo sapiens 160-173 29186034-9 2017 Many of the effects of IL-6 on vascular function and structure are representative of loss or reductions in nitric oxide (NO) bioavailability. Nitric Oxide 107-119 interleukin 6 Homo sapiens 23-27 29186034-10 2017 IL-6 has direct effects on endothelial nitric oxide synthase activity and expression as well as increasing vascular superoxide, which rapidly inactivates NO thereby limiting NO bioavailability. Superoxides 116-126 interleukin 6 Homo sapiens 0-4 28893353-4 2017 Human normal cholangiocyte H69 cells were used for in vitro studies to determine the mechanism by which adenosine and the A2bAR induce release of IL-6. Adenosine 104-113 interleukin 6 Homo sapiens 146-150 29416638-7 2018 Nicotine-treated hUC-MSCs produce higher level of IL-6. Nicotine 0-8 interleukin 6 Homo sapiens 50-54 29186865-7 2017 Vitamin D could restore cell viability, and inflammatory and oxidative status, as shown by cell metabolic activity, interleukin-6 (IL-6) levels and reactive oxygen species (ROS) production, respectively. Vitamin D 0-9 interleukin 6 Homo sapiens 116-129 29186865-7 2017 Vitamin D could restore cell viability, and inflammatory and oxidative status, as shown by cell metabolic activity, interleukin-6 (IL-6) levels and reactive oxygen species (ROS) production, respectively. Vitamin D 0-9 interleukin 6 Homo sapiens 131-135 28722170-1 2017 In chronic lymphocytic leukemia (CLL) cells, both interleukin-6 (IL-6) and the B-cell receptor (BCR) activate Janus kinase 2 (JAK2) and induce the phosphorylation of signal transduction and activator of transcription 3 (STAT3) on tyrosine 705 residues. Tyrosine 230-238 interleukin 6 Homo sapiens 50-63 28722170-1 2017 In chronic lymphocytic leukemia (CLL) cells, both interleukin-6 (IL-6) and the B-cell receptor (BCR) activate Janus kinase 2 (JAK2) and induce the phosphorylation of signal transduction and activator of transcription 3 (STAT3) on tyrosine 705 residues. Tyrosine 230-238 interleukin 6 Homo sapiens 65-69 28722170-8 2017 The IgM-induced production of IL-6 prompted the phosphorylation of STAT3 on tyrosine residues. Tyrosine 76-84 interleukin 6 Homo sapiens 30-34 28993518-5 2017 Unexpectedly, naringenin inhibits TNF-alpha and IL-6 secretion in macrophages and T cells without interfering with the TLR signaling cascade, cytokine mRNA stability, or protein translation. naringenin 14-24 interleukin 6 Homo sapiens 48-52 29132429-7 2017 Correlation analysis elucidated that the water content was strongly correlated with local skin indices, such as the ceramide composition, redness, blood flow, and TNFalpha in the stratum corneum, whereas roughness was correlated with the systemic indices, such as serum insulin, leptin, and IL-6. Water 41-46 interleukin 6 Homo sapiens 291-295 29142506-8 2017 Glycated hemoglobin levels measured after 6-month glucose-lowering treatment appeared to be inversely correlated with plasma anti-IL1alpha IgG (r=-0.477, df=17, p=0.039) and anti-IL6 IgG (r=-0.519, df=17, p=0.023) although such correlation failed to survive the Bonferroni correction. Glucose 50-57 interleukin 6 Homo sapiens 179-182 28852804-8 2017 RESULTS: Podocytes exposed to a diabetic environment (high glucose, high insulin and the proinflammatory cytokines TNF-alpha and IL-6) become insulin resistant with respect to glucose uptake and activation of phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) signalling. Glucose 176-183 interleukin 6 Homo sapiens 129-133 29226077-5 2017 We also revealed that antagonists of tumor necrosis factor, IL-6 and IL-1beta down-regulated ROS production of RA FLS induced by leptin, which subsequently attenuated RA FLS migration and HUVEC tube formation. Reactive Oxygen Species 93-96 interleukin 6 Homo sapiens 60-64 29099041-16 2017 In conclusion, in this study, CRP, IL-6, and TNF-alpha were significantly elevated in obese Egyptian type 2 diabetics and were positively correlated with insulin resistance, non-HDL and triglycerides. Triglycerides 186-199 interleukin 6 Homo sapiens 35-39 28916714-0 2017 Interleukin-6 blockade raises LDL via reduced catabolism rather than via increased synthesis: a cytokine-specific mechanism for cholesterol changes in rheumatoid arthritis. Cholesterol 128-139 interleukin 6 Homo sapiens 0-13 31453235-7 2017 Our experiments revealed on average an about four-fold increased surface expression, a four-fold higher signaling amplitude, and a significantly higher potency of odorant-induced cAMP signaling of six different human IL-6-HaloTag -ORs across five different receptor families in NxG 108CC15 cells, as compared to their Rho-tag-HaloTag constructs. Cyclic AMP 179-183 interleukin 6 Homo sapiens 217-221 28418601-0 2017 Two arginine residues in the COOH-terminal of human beta-defensin-3 constitute an essential motif for antimicrobial activity and IL-6 production. Arginine 4-12 interleukin 6 Homo sapiens 129-133 28649040-6 2017 The OPAO assay showed the best correlation with the production of intracellular reactive oxygen species by NCI-H292 cell line assessed by DCFH oxidation and with the expression of anti-oxidant genes (superoxide dismutase 2, heme-oxygenase-1) as well as the proinflammatory response (Interleukin 6) when exposed from 1 to 10 mug/cm2. Reactive Oxygen Species 80-103 interleukin 6 Homo sapiens 283-296 28892096-8 2017 Cholangioids exposed to hydrogen peroxide exhibited cellular senescence and the senescence-associated secretory phenotype (SASP; increased IL-6, p21, SA-beta-Gal, yH2A.x and p16 expression). Hydrogen Peroxide 24-41 interleukin 6 Homo sapiens 139-143 28864229-19 2017 GW was also significantly related to circulating IL-6. glycyltryptophan 0-2 interleukin 6 Homo sapiens 49-53 28752178-7 2017 Tofacitinib significantly down-regulated CTS-induced expression of ADAMTS4, ADAMTS5, MMP13, and RUNX2, and the release of IL-6 in supernatant by chondrocytes. tofacitinib 0-11 interleukin 6 Homo sapiens 122-126 31271140-11 2017 In addition, we revealed that free paclitaxel treatment resulted in higher levels of IL-6, IL-10, PDL-1, TGF-beta1, TNF-alpha and VEGF, while the expression levels of these inflammatory factors were much lower in the other two groups, especially in the Nano-PTX-GEL treated groups. Paclitaxel 35-45 interleukin 6 Homo sapiens 85-89 28598282-9 2017 Also, high glucose increased TRAF6, interleukin (IL)-6, TNF-alpha, and chemical chemokine ligand (CCL) 2 levels, whereas it decreased IL-10 level. Glucose 11-18 interleukin 6 Homo sapiens 36-54 28598282-12 2017 Overexpression of miR-126 significantly abrogated high glucose-induced secretion of proinflammatory cytokines such as IL-6, TNF-alpha, and CCL2 and promoted production of IL-10. Glucose 55-62 interleukin 6 Homo sapiens 118-122 29190601-8 2017 Comparing the steroid-resistant group with the steroid-sensitive group, significant association was found at genotypic level in case of IL-6-G174C (GG versus CC, P = .03; OR, 5.52; 95% CI, 1.39 to 21.89), but no association was found regarding GG versus GC. Steroids 14-21 interleukin 6 Homo sapiens 136-140 29190601-8 2017 Comparing the steroid-resistant group with the steroid-sensitive group, significant association was found at genotypic level in case of IL-6-G174C (GG versus CC, P = .03; OR, 5.52; 95% CI, 1.39 to 21.89), but no association was found regarding GG versus GC. Steroids 47-54 interleukin 6 Homo sapiens 136-140 29190601-10 2017 CONCLUSIONS: IL-6-G174C and TNFalpha-G308A polymorphisms may affect susceptibility to idiopathic nephrotic syndrome and might affect steroid response in INS patients. Steroids 133-140 interleukin 6 Homo sapiens 13-17 28678591-0 2017 Cypermethrin inhibits interleukin-6-induced androgen receptor transactivation through signal transducer and activator of transcription 3. cypermethrin 0-12 interleukin 6 Homo sapiens 22-35 27846790-4 2017 FINDINGS: Administration of ROS and ATO both significantly reduced the concentrations of TC, LDL-C, TG, hs-CRP, and IL-6, but increased high-density lipoproteincholesterol (HDL-C), ALB, PA, and TF levels. Atorvastatin 36-39 interleukin 6 Homo sapiens 116-120 28678591-6 2017 The study indicates cypermethrin inhibits IL-6-induced AR signaling by suppressing the interaction between the AR and STAT3. cypermethrin 20-32 interleukin 6 Homo sapiens 42-46 28678591-7 2017 We provide a novel mechanism of cypermethrin-mediated antagonism on IL-6-induced AR activation associated with STAT3. cypermethrin 32-44 interleukin 6 Homo sapiens 68-72 28678591-1 2017 The insecticide cypermethrin has been considered as an endocrine-disrupting chemicals (EDCs) with anti-androgenic activity by interfering with interleukin-6 (IL-6) - induced ligand-independent AR signaling. cypermethrin 16-28 interleukin 6 Homo sapiens 143-156 28678591-1 2017 The insecticide cypermethrin has been considered as an endocrine-disrupting chemicals (EDCs) with anti-androgenic activity by interfering with interleukin-6 (IL-6) - induced ligand-independent AR signaling. cypermethrin 16-28 interleukin 6 Homo sapiens 158-162 28678591-5 2017 Cypermethrin did not affect the phosphorylation level of STAT3 induced by IL-6, while suppressed the AR-STAT3 interaction induced by IL-6 significantly at the concentration of 10-5 M (p < 0.05). cypermethrin 0-12 interleukin 6 Homo sapiens 133-137 28899503-16 2017 Secretion of IL-8 and IL-6 was reduced by STW1 and ASA. Aspirin 51-54 interleukin 6 Homo sapiens 22-26 28736282-8 2017 Curcumin inhibited the proliferation of IMQ-induced differentiated HaCaT cells (Psoriatic-like cells) by down-regulation of pro-inflammatory cytokines, interleukin-17, tumor necrosis factor-alpha, interferon-gamma, and interleukin-6. Curcumin 0-8 interleukin 6 Homo sapiens 219-232 29228683-8 2017 Analysis of the IL-6 modulating cereblon-binding protein KPNA2 showed the similar degradation capacity of lenalidomide and pomalidomide without explaining the divergent effects. pomalidomide 123-135 interleukin 6 Homo sapiens 16-20 28697991-10 2017 In the morphine abuser, a decrease in pain threshold, an increase in IL-6 and a decrease in IL-10 levels were evident compared with non-abuser subjects. Morphine 7-15 interleukin 6 Homo sapiens 69-73 28663336-7 2017 PGE2, PGI2, and PGA2 exhibited the most potent barrier-enhancing effects and most efficient attenuation of thrombin-induced EC permeability and contractile response, whereas PGI2 effectively suppressed thrombin-induced permeability but was less efficient in the attenuation of prolonged EC hyperpermeability caused by interleukin-6 or bacterial wall lipopolysaccharide, LPS. Dinoprostone 0-4 interleukin 6 Homo sapiens 318-331 28356286-5 2017 With early treatment, cisplatin nephrotoxicity was attenuated as evidenced by decreased blood urea nitrogen (BUN) and reduced apoptosis and tubular injury scores on day 3 Early treatment resulted in downregulation of intrarenal monocyte chemotactic protein-1 and IL-6 expression and upregulation of IL-10 and VEGF expression. Cisplatin 22-31 interleukin 6 Homo sapiens 263-267 28434547-9 2017 RESULTS: The IL-6 values of the SDC group were significantly lower postoperatively than in the placebo group. S-[2-(Aminosulfonyl)ethyl]-D-Cysteine 32-35 interleukin 6 Homo sapiens 13-17 28881271-12 2017 In VSMC, FSAP-induced expression of AREG and IL6 was blocked by cAMP and MAPK pathway inhibitors indicating that multiple signalling pathways are likely to be involved. Cyclic AMP 64-68 interleukin 6 Homo sapiens 45-48 28601733-8 2017 A non-significant positive correlation was observed between clinical parameters and IL-6 and IL-8 levels except at baseline, a significant correlation was observed between PPD &IL 6 levels in group II. ppd & 172-177 interleukin 6 Homo sapiens 181-185 28709031-2 2017 Even though several in vivo and in vitro studies showed positive associations of BPA exposure with pro-inflammatory cytokines such as tumor necrosis factor-alpha and interleukin (IL)-6, the mechanism by which BPA induces inflammation is unclear. bisphenol A 81-84 interleukin 6 Homo sapiens 166-184 28946937-10 2017 Our data also suggest that secreted IL-6 regulates CLB2.0-induced MUC5AC and MUC1 expression via ROS-mediated downregulation of claudin-1 expression to maintain mucus homeostasis in the airway. ros 97-100 interleukin 6 Homo sapiens 36-40 26965709-7 2017 Furthermore, a recent study shows that DEP-induced intracellular ROS may cause the release of pro-inflammatory TNF-alpha and IL-6, which may induce endothelial permeability as well by promoting VEGF-A secretion independently of HO-1 activation. Reactive Oxygen Species 65-68 interleukin 6 Homo sapiens 125-129 27642057-9 2017 CARB meal was found to increase plasma IL-6 whereas MUFA meal elevated plasma D-dimer postprandially compared with SAFA meal (P < 0.05). Carbohydrates 0-4 interleukin 6 Homo sapiens 39-43 28946937-5 2017 CLB2.0-induced IL-6 secretion was mediated by ROS. ros 46-49 interleukin 6 Homo sapiens 15-19 28946937-6 2017 The ROS scavenger N-acetylcysteine inhibited CLB2.0-induced IL-6 secretion, thereby decreasing the CLB2.0-induced MUC5AC expression, whereas CLB2.0-induced MUC1 expression increased. ros 4-7 interleukin 6 Homo sapiens 60-64 28946937-6 2017 The ROS scavenger N-acetylcysteine inhibited CLB2.0-induced IL-6 secretion, thereby decreasing the CLB2.0-induced MUC5AC expression, whereas CLB2.0-induced MUC1 expression increased. Acetylcysteine 18-34 interleukin 6 Homo sapiens 60-64 29093604-9 2017 Secretion of the cytokines CCL5, CCL2 and IL-6 increased after paclitaxel treatment in several endometrial cancer cell lines, but no general effect on cytokine secretion was detected after heparin treatment. Paclitaxel 63-73 interleukin 6 Homo sapiens 42-46 28664473-8 2017 The expression levels of VEGF, IL-6, and IL-10 also decreased in response to treatment with QTF or AZM. qtf 92-95 interleukin 6 Homo sapiens 31-35 29142375-9 2017 Reduced levels of IL-1, IL-6, TNF-alpha, IFN, and CRP were observed in the atorvastatin group. Atorvastatin 75-87 interleukin 6 Homo sapiens 24-28 29093604-11 2017 Conclusion: Further in-depth studies are needed to investigate the functions of cytokines CCL2, CCL5 and IL-6 in endometrial cancer cells treated with paclitaxel. Paclitaxel 151-161 interleukin 6 Homo sapiens 105-109 28837884-0 2017 Macrophages induce EMT to promote invasion of lung cancer cells through the IL-6-mediated COX-2/PGE2/beta-catenin signalling pathway. Dinoprostone 96-100 interleukin 6 Homo sapiens 76-80 28167299-9 2017 Calcipotriol and dexamethasone additively reduced the secretions of IL-6, IFN-gamma, basic FGF and VEGF in TNF-alpha stimulated SSC. Dexamethasone 17-30 interleukin 6 Homo sapiens 68-72 28455791-4 2017 Resveratrol abolished HSC-induced angiogenesis and suppressed ROS production and IL-6 and CXCR4 receptor expression in HepG2 cells by down-regulating Gli-1 expression. Resveratrol 0-11 interleukin 6 Homo sapiens 81-85 28837884-7 2017 In the co-culture process, interleukin-6 (IL-6) induced the COX-2/PGE2 pathway in lung cancer cells, which subsequently promoted beta-catenin translocation from the cytoplasm to the nucleus, resulting in epithelial-mesenchymal transition (EMT) and lung cancer cell invasion. Dinoprostone 66-70 interleukin 6 Homo sapiens 27-40 28837884-7 2017 In the co-culture process, interleukin-6 (IL-6) induced the COX-2/PGE2 pathway in lung cancer cells, which subsequently promoted beta-catenin translocation from the cytoplasm to the nucleus, resulting in epithelial-mesenchymal transition (EMT) and lung cancer cell invasion. Dinoprostone 66-70 interleukin 6 Homo sapiens 42-46 28837884-8 2017 Our findings show that the IL-6-dependent COX-2/PGE2 pathway induces EMT to promote invasion of tumour cells through beta-catenin activation during the interaction between macrophages and lung cancer cells, which suggests that inhibition of COX-2/PGE2 or macrophages has the potential to suppress metastasis of lung cancer cells. Dinoprostone 48-52 interleukin 6 Homo sapiens 27-31 28837884-8 2017 Our findings show that the IL-6-dependent COX-2/PGE2 pathway induces EMT to promote invasion of tumour cells through beta-catenin activation during the interaction between macrophages and lung cancer cells, which suggests that inhibition of COX-2/PGE2 or macrophages has the potential to suppress metastasis of lung cancer cells. Dinoprostone 247-251 interleukin 6 Homo sapiens 27-31 28961200-0 2017 N-(4-bromophenethyl) Caffeamide Protects Skin from UVB-Induced Inflammation Through MAPK/IL-6/NF-kappaB-Dependent Signaling in Human Skin Fibroblasts and Hairless Mouse Skin. n-(4-bromophenethyl) 0-20 interleukin 6 Homo sapiens 89-93 28126360-7 2017 IL-6 was weakly inverse associated with omega-6 PUFA, and highly increased in nicotine users. Nicotine 78-86 interleukin 6 Homo sapiens 0-4 29132841-6 2017 Pg-3-glc and PGA at 0.08 mumol/L increased the concentration of IL-10 (P<.01 and P<.001, respectively), but there was no effect on tumor necrosis factor-alpha, IL-1beta, IL-6, and IL-8, and there were no effects of the other compounds. Folic Acid 13-16 interleukin 6 Homo sapiens 176-180 28787261-16 2017 IL-6 and osteopontin correlated significantly with radiologic response after TAE. tae 77-80 interleukin 6 Homo sapiens 0-4 28666365-4 2017 Chronic 30 mg/l CdCl2 treatment elevated murine blood Cd level comparable to that of low dose Cd-exposed humans, had no effect on blood total and differential leukocyte counts, but reduced neutrophil infiltration, chemokines (CXCL1 and CXCL2), and proinflammatory cytokines (TNFalpha, IL-1beta, and IL-6) expression in wounded tissue at early stage after injury. Cadmium 16-18 interleukin 6 Homo sapiens 299-303 28433754-10 2017 Overall, we report that miR-146a suppressed IL-6 signaling, leading to reduced levels of STAT3 and VEGF in REC in high glucose conditions, leading to decreased apoptosis. Glucose 119-126 interleukin 6 Homo sapiens 44-48 28894133-8 2017 Rapamycin abrogated 5-MTP-mediated suppression of p16, p21, SA-beta-Gal and IL-6 and rise of BrdU incorporation. Sirolimus 0-9 interleukin 6 Homo sapiens 76-80 28716525-5 2017 Pretreatment of IL-6 inhibitor Tocilizumab could inhibit metastasis the HCC cell treated with CM-pTAFs in vitro and in vivo. ptafs 97-102 interleukin 6 Homo sapiens 16-20 28946703-4 2017 Moreover, IL-6-stimulated phosphorylation of STAT3 was significantly suppressed in U266 cells by the administration of A. katsumadai EtOH extract and Compounds 1 and 2. Ethanol 133-137 interleukin 6 Homo sapiens 10-14 28754685-4 2017 When IL6Rchi was co-expressed with an engineered Ca2+-activated RhoA (CaRQ), it enabled directed migration to IL6 in cells that have no such natural ability. carq 70-74 interleukin 6 Homo sapiens 5-8 28481867-6 2017 The mechanism whereby RB inactivation increases IL-6 production in MCF-7 cells appeared to involve fatty acid oxidation (FAO)-dependent mitochondrial metabolism and c-Jun NH(2)-terminal kinase (JNK). Fatty Acids 99-109 interleukin 6 Homo sapiens 48-52 28481867-7 2017 In addition, IL-6, via STAT3-mediated feedback to mitochondria, autonomously adjusts mitochondrial superoxide to levels suitable to maintain stem cell-like activity. Superoxides 99-109 interleukin 6 Homo sapiens 13-17 28582666-9 2017 An ELISA-like assay with CdSe/ZnS quantum dot institution (QLISA; Quantum dot-linked immunosorbent assay) was developed to detect 0.05ng/mL IL-6, which makes it sufficiently sensitive as an immunosorbent assay. Zinc 30-33 interleukin 6 Homo sapiens 140-144 28878571-0 2017 Ribonucleic acid interference knockdown of IL-6 enhances the efficacy of cisplatin in laryngeal cancer stem cells by down-regulating the IL-6/STAT3/HIF1 pathway. Cisplatin 73-82 interleukin 6 Homo sapiens 43-47 28878571-0 2017 Ribonucleic acid interference knockdown of IL-6 enhances the efficacy of cisplatin in laryngeal cancer stem cells by down-regulating the IL-6/STAT3/HIF1 pathway. Cisplatin 73-82 interleukin 6 Homo sapiens 137-141 28878571-2 2017 This study aimed to investigate whether interleukin-6 (IL-6) knockdown may enhance the efficacy of cisplatin in laryngeal cancer stem cells (CSC) and the potential involvement of the signal transducer and activator of transcription 3 (STAT3) and hypoxia-inducible factor 1 (HIF1) in this effect. Cisplatin 99-108 interleukin 6 Homo sapiens 40-53 28878571-2 2017 This study aimed to investigate whether interleukin-6 (IL-6) knockdown may enhance the efficacy of cisplatin in laryngeal cancer stem cells (CSC) and the potential involvement of the signal transducer and activator of transcription 3 (STAT3) and hypoxia-inducible factor 1 (HIF1) in this effect. Cisplatin 99-108 interleukin 6 Homo sapiens 55-59 28878571-13 2017 Results from the xenograft study showed that the combination of IL-6 knockdown and cisplatin further inhibited the growth of xenografts as compared with that obtained in the cisplatin-injected group alone. Cisplatin 174-183 interleukin 6 Homo sapiens 64-68 28878571-15 2017 IL-6, STAT3 and HIF1 immunoreactive cell counts were further reduced in tissue where IL-6 knockdown was combined with cisplatin treatment as compared with tissue receiving cisplatin alone. Cisplatin 118-127 interleukin 6 Homo sapiens 0-4 28878571-15 2017 IL-6, STAT3 and HIF1 immunoreactive cell counts were further reduced in tissue where IL-6 knockdown was combined with cisplatin treatment as compared with tissue receiving cisplatin alone. Cisplatin 172-181 interleukin 6 Homo sapiens 85-89 28878571-16 2017 CONCLUSIONS: IL-6 knockdown can increase chemo-drug efficacy of cisplatin, inhibit tumor growth and reduce the potential for tumor recurrence and metastasis in laryngeal cancer. Cisplatin 64-73 interleukin 6 Homo sapiens 13-17 28524237-11 2017 In vitro dialysis of cytokine-enriched plasma samples with MCO and HCO membranes reduces IL-6 levels. mco 59-62 interleukin 6 Homo sapiens 89-93 28854707-4 2017 The mean level of IL-6 was initially elevated in Lesch typology 2 alcohol abusers and declined to the reference range after detoxification. Alcohols 66-73 interleukin 6 Homo sapiens 18-22 28854707-5 2017 Lesch typology 3 alcohol abusers showed normal levels of IL-6 at both time points. Alcohols 17-24 interleukin 6 Homo sapiens 57-61 28684587-9 2017 Postexercise changes in blood lactate and IL-6 correlated with the area under the curve values for ghrelin (r = -0.60, P < 0.001) and GLP-1 (r = 0.42, P = 0.017), respectively. Ghrelin 99-106 interleukin 6 Homo sapiens 42-46 28507168-3 2017 Circulating IL-6 is thought to maintain energy status during exercise by acting as an energy sensor for contracting muscle and stimulating glucose production. Glucose 139-146 interleukin 6 Homo sapiens 12-16 28507168-7 2017 Recent intervention studies have explored the role of mixed meals or carbohydrate, protein, omega-3 fatty acid, or antioxidant supplementation in mitigating exercise-induced increases in IL-6. Carbohydrates 69-81 interleukin 6 Homo sapiens 187-191 28700977-6 2017 Hypoxia-induced Tumor Necrosis Factor-alpha (TNF-alpha), Interleukin 6 (IL-6), and Interleukin 8 (IL-8) release were significantly reduced in the neferine pretreated samples indicating its anti-inflammatory role. neferine 146-154 interleukin 6 Homo sapiens 57-70 28700977-6 2017 Hypoxia-induced Tumor Necrosis Factor-alpha (TNF-alpha), Interleukin 6 (IL-6), and Interleukin 8 (IL-8) release were significantly reduced in the neferine pretreated samples indicating its anti-inflammatory role. neferine 146-154 interleukin 6 Homo sapiens 72-76 28883755-3 2017 Here, we demonstrate that hypoxia, reactive oxygen species (ROS), and differential concentration of glucose influence the expression of cytokines and chemokines, such as IL-6, IL-8, and IP-10, in human glial cell lines. Reactive Oxygen Species 35-58 interleukin 6 Homo sapiens 170-174 29075409-9 2017 CONCLUSIONS: In patients with diabetes and periodontal disease, treatment with topical melatonin was associated with a significant improvement in the gingival index and in pocket depth, and a statistically significant reduction in concentrations of interleukin-1beta, interleukin-6 and prostaglandin E2 in gingival crevicular fluid. Melatonin 87-96 interleukin 6 Homo sapiens 268-281 28684418-7 2017 The HO-1 inducer cobalt protoporphyrin IX more efficiently attenuated PGE2 and IL-6 release in HG+IL-1beta-treated cells than in NG+IL-1beta-treated cells. protoporphyrin IX 24-41 interleukin 6 Homo sapiens 79-83 28883755-3 2017 Here, we demonstrate that hypoxia, reactive oxygen species (ROS), and differential concentration of glucose influence the expression of cytokines and chemokines, such as IL-6, IL-8, and IP-10, in human glial cell lines. Reactive Oxygen Species 60-63 interleukin 6 Homo sapiens 170-174 28883755-3 2017 Here, we demonstrate that hypoxia, reactive oxygen species (ROS), and differential concentration of glucose influence the expression of cytokines and chemokines, such as IL-6, IL-8, and IP-10, in human glial cell lines. Glucose 100-107 interleukin 6 Homo sapiens 170-174 28883755-4 2017 Treatment with cobalt chloride (CoCl2) and hydrogen peroxide (H2O2) significantly increased the expression levels of IL-6, IL-8, and IP-10 in a dose-dependent manner in CRT-MG and U251-MG astroglioma cells, but not in microglia cells. Hydrogen Peroxide 43-60 interleukin 6 Homo sapiens 117-121 28883755-4 2017 Treatment with cobalt chloride (CoCl2) and hydrogen peroxide (H2O2) significantly increased the expression levels of IL-6, IL-8, and IP-10 in a dose-dependent manner in CRT-MG and U251-MG astroglioma cells, but not in microglia cells. Hydrogen Peroxide 62-66 interleukin 6 Homo sapiens 117-121 28185444-0 2017 Effect of Cis-palmitoleic acid supplementation on inflammation and expression of HNF4gamma, HNF4alpha and IL6 in patients with ulcerative colitis. palmitoleic acid 10-30 interleukin 6 Homo sapiens 106-109 28953677-0 2017 Effects of metformin treatment on serum levels of C-reactive protein and interleukin-6 in women with polycystic ovary syndrome: a meta-analysis: A PRISMA-compliant article. Metformin 11-20 interleukin 6 Homo sapiens 73-86 28953677-1 2017 BACKGROUND: Metformin is effective for the treatment of polycystic ovary syndrome (PCOS), but conflicting results regarding its impact on serum levels of C-reactive protein (CRP) and interleukin-6 (IL-6) in women with PCOS have been reported. Metformin 12-21 interleukin 6 Homo sapiens 183-196 28953677-1 2017 BACKGROUND: Metformin is effective for the treatment of polycystic ovary syndrome (PCOS), but conflicting results regarding its impact on serum levels of C-reactive protein (CRP) and interleukin-6 (IL-6) in women with PCOS have been reported. Metformin 12-21 interleukin 6 Homo sapiens 198-202 28953677-13 2017 In addition, we noticed that metformin treatment could decrease BMI in the CRP and IL-6 related studies (SMD = -0.45, 95% CI: -0.68 to -0.23; SMD = -0.44, 95% CI: -0.73 to -0.16). Metformin 29-38 interleukin 6 Homo sapiens 83-87 28185444-2 2017 The aim of this study was to evaluate the effect of Cis-palmitoleic acid supplementation on inflammatory activity and the expression of genes HNF4gamma, HNF4alpha and IL6 in the colonic mucosa of patients with active UC. palmitoleic acid 52-72 interleukin 6 Homo sapiens 167-170 28927099-0 2017 Interleukin-6 identified as an important factor in hypoxia- and aldehyde dehydrogenase-based gefitinib adaptive resistance in non-small cell lung cancer cells. Gefitinib 93-102 interleukin 6 Homo sapiens 0-13 28927099-6 2017 RNA-seq analysis revealed that interleukin-6 (IL-6) is an important common factor in hypoxia and ALDH-based gefitinib resistance, supported by inflammation-associated tumor necrosis factor, nuclear factor-kappaB and Janus kinase-signal transducer and activator of transcription signaling pathway enrichment. Gefitinib 108-117 interleukin 6 Homo sapiens 31-44 28927099-6 2017 RNA-seq analysis revealed that interleukin-6 (IL-6) is an important common factor in hypoxia and ALDH-based gefitinib resistance, supported by inflammation-associated tumor necrosis factor, nuclear factor-kappaB and Janus kinase-signal transducer and activator of transcription signaling pathway enrichment. Gefitinib 108-117 interleukin 6 Homo sapiens 46-50 28927099-7 2017 Furthermore, exposure of PC9 and HCC827 cells to IL-6 increased gefitinib adaptive resistance. Gefitinib 64-73 interleukin 6 Homo sapiens 49-53 28532672-1 2017 In this study, we found that catechins found in green tea (EGCG, EGC, and EC) differentially interfere with the IL-1beta signaling pathway which regulates the expression of pro-inflammatory mediators (IL-6 and IL-8) and Cox-2 in primary human rheumatoid arthritis synovial fibroblasts (RASFs). Catechin 29-38 interleukin 6 Homo sapiens 201-205 28351806-12 2017 Our results showed the strongest significant positive associations for IL-6 with MI, ST and TB in elderly people. st 85-87 interleukin 6 Homo sapiens 71-75 28810889-10 2017 Cirrhotic patients with lower DHEAS/cortisol ratio (<1.50) had higher levels of interleukin-6 and tumor necrosis factor alpha, higher Sequential Organ Failure Assessment scores, and higher rates of CIRCI and hospital mortality. Hydrocortisone 36-44 interleukin 6 Homo sapiens 83-128 27557477-8 2017 The addition of IL-6 did not change efflux transport of rebamipide even though efflux transport of digoxin, a typical substrate of P-gp, was significantly decreased by the addition of IL-6, indicating decrease of the function of P-gp. Digoxin 99-106 interleukin 6 Homo sapiens 184-188 28851867-5 2017 Exposure of DCs to the new class of triterpenoid CDDO-DFPA (RTA-408) results in the induction of HO-1, TGF-beta, and IL-10, as well as the repression of NF-kappaB, EDN-1 and pro-inflammatory cytokines IL-6, IL-12, and TNFalpha. cddo-dfpa 49-58 interleukin 6 Homo sapiens 201-205 28683470-1 2017 BACKGROUND: In two clinical trials of the vascular endothelial growth factor (VEGF) receptor inhibitor pazopanib in advanced renal cell carcinoma (mRCC), we found interleukin-6 as predictive of pazopanib benefit. pazopanib 103-112 interleukin 6 Homo sapiens 163-176 29108270-3 2017 In the same model, S-adenosylmethionine (SAMe) and methylthioadenosine (MTA) inhibited IL-6/STAT3 and lowered tumor burden. S-Adenosylmethionine 19-39 interleukin 6 Homo sapiens 87-91 29108270-3 2017 In the same model, S-adenosylmethionine (SAMe) and methylthioadenosine (MTA) inhibited IL-6/STAT3 and lowered tumor burden. 5'-methylthioadenosine 51-70 interleukin 6 Homo sapiens 87-91 28683470-1 2017 BACKGROUND: In two clinical trials of the vascular endothelial growth factor (VEGF) receptor inhibitor pazopanib in advanced renal cell carcinoma (mRCC), we found interleukin-6 as predictive of pazopanib benefit. pazopanib 194-203 interleukin 6 Homo sapiens 163-176 28625979-3 2017 We found that ISX-mediated IL6-induced expression of the tryptophan catabolic enzymes Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase in hepatocellular carcinoma cells, resulting in an ISX-dependent increase in the tryptophan catabolite kynurenine and its receptor aryl hydrocarbon receptor (AHR). Tryptophan 57-67 interleukin 6 Homo sapiens 27-30 28625979-3 2017 We found that ISX-mediated IL6-induced expression of the tryptophan catabolic enzymes Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase in hepatocellular carcinoma cells, resulting in an ISX-dependent increase in the tryptophan catabolite kynurenine and its receptor aryl hydrocarbon receptor (AHR). Tryptophan 127-137 interleukin 6 Homo sapiens 27-30 28722106-6 2017 Moreover, muscle-derived IL-6 appears to have direct anti-inflammatory effects and serves as a mechanism to improve glucose tolerance. Glucose 116-123 interleukin 6 Homo sapiens 25-29 27866306-8 2017 Collectively, our data revealed that nanomolar BPA can trigger the malignancy of NB cells via activation of NF-kappaB/IL-6 signals, suggesting that more attention should be paid to the potential health risks of daily BPA intake. bisphenol A 47-50 interleukin 6 Homo sapiens 118-122 28646302-9 2017 Interleukin (IL)-1beta, IL-6, IL-8 and IL-10 levels in the serum all increased POST-1h (P > 0.05) but returned to pre-exercise levels POST-1d. Hydrogen 84-86 interleukin 6 Homo sapiens 24-28 27866306-0 2017 Low Dose of Bisphenol A Activates NF-kappaB/IL-6 Signals to Increase Malignancy of Neuroblastoma Cells. bisphenol A 12-23 interleukin 6 Homo sapiens 44-48 27866306-5 2017 The neutralization antibody of IL-6 can abolish BPA-induced proliferation and invasion of NB cells. bisphenol A 48-51 interleukin 6 Homo sapiens 31-35 28550731-0 2017 Xanthotoxin suppresses LPS-induced expression of iNOS, COX-2, TNF-alpha, and IL-6 via AP-1, NF-kappaB, and JAK-STAT inactivation in RAW 264.7 macrophages. Methoxsalen 0-11 interleukin 6 Homo sapiens 77-81 28477980-11 2017 ROS scavenger N-acetyl-L-cysteine (NAC) and Akt inhibitor MK2206 reduced TNF-alpha-induced mRNA expression of MCP-1 and IL-6 in VAFs. Reactive Oxygen Species 0-3 interleukin 6 Homo sapiens 120-124 28853522-11 2017 The addition of vitamin D significantly down-regulated IL6 and IL8 secretion and up-regulated ADAMST13 expression. Vitamin D 16-25 interleukin 6 Homo sapiens 55-58 28550731-3 2017 Xanthotoxin inhibited production of nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor (TNF-alpha), and interleukin-6 (IL-6) by the LPS-induced macrophages in a concentration-dependent manner. Methoxsalen 0-11 interleukin 6 Homo sapiens 119-132 28550731-10 2017 Taken together, these results indicate that xanthotoxin decreases NO, PGE2, TNF-alpha, and IL-6 production by downregulation of the NF-kappaB, AP-1, and JAK/STAT signaling pathways in LPS-induced RAW 264.7 macrophages. Methoxsalen 44-55 interleukin 6 Homo sapiens 91-95 28550731-3 2017 Xanthotoxin inhibited production of nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor (TNF-alpha), and interleukin-6 (IL-6) by the LPS-induced macrophages in a concentration-dependent manner. Methoxsalen 0-11 interleukin 6 Homo sapiens 134-138 28551532-11 2017 Kynurenine (50-100muM) and tryptophan (50-100muM) decreased while tryptophan (5muM) and kynurenic acid (100muM) increased the release of IL-6. Tryptophan 66-76 interleukin 6 Homo sapiens 137-141 28932561-8 2017 The concentrations of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-2R, IL-6, IL-8 and IL-10 in plasma on the first postoperative day significantly increased in the GAL group than in the non-GAL group (P<0.05). Galactose 177-180 interleukin 6 Homo sapiens 84-88 28750089-3 2017 One cationic AMP, GW-A2, demonstrated the ability to inhibit the expression levels of nitric oxide (NO), inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in lipopolysaccharide (LPS)-activated macrophages. Adenosine Monophosphate 13-16 interleukin 6 Homo sapiens 205-218 28292711-0 2017 CO-releasing molecules CORM2 attenuates angiotensin II-induced human aortic smooth muscle cell migration through inhibition of ROS/IL-6 generation and matrix metalloproteinases-9 expression. ros 127-130 interleukin 6 Homo sapiens 131-135 28750089-3 2017 One cationic AMP, GW-A2, demonstrated the ability to inhibit the expression levels of nitric oxide (NO), inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in lipopolysaccharide (LPS)-activated macrophages. Adenosine Monophosphate 13-16 interleukin 6 Homo sapiens 220-224 28686728-4 2017 In the same way, the involvement of calcium, phospholipase C and A2 in PAF-induced IL-6 production, in different cells types, has been shown; however, the importance of the Jak/STAT pathway and its regulation by protein-tyrosine phosphatases in this response have not been addressed. Calcium 36-43 interleukin 6 Homo sapiens 83-87 28794655-4 2017 For this reason, we examined the effects of ADPbetas (ADP analog) on the expression and the release of IL-1beta, IL-6, and TNF-alpha. Adenosine Diphosphate 44-47 interleukin 6 Homo sapiens 113-117 28903416-7 2017 786-O RCC cells secrete high IL-6 levels after low dose stimulation with the TKIs sorafenib, sunitinib and pazopanib, inducing activation of AKT-mTOR pathway, NFkappaB, HIF-2alpha and VEGF expression. pazopanib 107-116 interleukin 6 Homo sapiens 29-33 28319068-7 2017 Mechanistic studies demonstrate that iron increases metastatic spread by facilitating invasion through expression of matrix metalloproteases and synthesis of interleukin 6 (IL-6). Iron 37-41 interleukin 6 Homo sapiens 158-171 28319068-7 2017 Mechanistic studies demonstrate that iron increases metastatic spread by facilitating invasion through expression of matrix metalloproteases and synthesis of interleukin 6 (IL-6). Iron 37-41 interleukin 6 Homo sapiens 173-177 28704555-1 2017 Interleukin-6 (IL-6) has been recently shown to play a central role in glucose homeostasis, since it stimulates the production and secretion of Glucagon-like Peptide-1 (GLP-1) from intestinal L-cells and pancreas, leading to an enhanced insulin response. Glucose 71-78 interleukin 6 Homo sapiens 0-13 28704555-1 2017 Interleukin-6 (IL-6) has been recently shown to play a central role in glucose homeostasis, since it stimulates the production and secretion of Glucagon-like Peptide-1 (GLP-1) from intestinal L-cells and pancreas, leading to an enhanced insulin response. Glucose 71-78 interleukin 6 Homo sapiens 15-19 28704555-5 2017 A two-compartment description was adopted to model plasma IL-6 changes in response to oxygen uptake"s variation during an exercise bout. Oxygen 86-92 interleukin 6 Homo sapiens 58-62 28747177-10 2017 RESULTS: Positive correlations of DeltaCr were found with BUN, admission Cr, GRACE score, IL-1beta, IL-6, NT-ProBNP and age, and negative correlations with systolic blood pressure, mean-BP, diastolic-BP and LxA4. Creatinine 39-41 interleukin 6 Homo sapiens 100-104 28724796-4 2017 Host IL-6 was identified as a pivotal cytokine mediator, as was host indoleamine 2,3-dioxygenase (IDO-1), which was upregulated in GVHD in an IL-6-dependent manner in microglial cells and was accompanied by dysregulated tryptophan metabolism in the dorsal raphe nucleus and prefrontal cortex. Tryptophan 220-230 interleukin 6 Homo sapiens 142-146 28686675-4 2017 We hypothesized that cetirizine, a second-generation histamine H1 receptor antagonist able to reduce the levels of IL-6, might improve IFNbeta-induced FLS. Cetirizine 21-31 interleukin 6 Homo sapiens 115-119 28511912-5 2017 Under TNF-alpha stimulation, Atractylodin induced the tri-methylation of histone H3 at lysine residue 9, which impaired the binding between NF-kappaB and the IL-6 promoter on the genomic DNA. Lysine 87-93 interleukin 6 Homo sapiens 158-162 28740415-7 2017 Interestingly, our experiments show that the two fractions regulated cytokine secretion differently: ESM depressed inflammation by increased secretion of the anti-inflammatory cytokine IL-10 while the carbohydrate fraction reduced secretions of the pro inflammatory cytokines IL-1beta and IL-6. Carbohydrates 201-213 interleukin 6 Homo sapiens 289-293 28414053-6 2017 PPQ-B also significantly decreased the production of inflammatory factors TNF-alpha, IL-6, RANTES and KC in IAV infected lungs and A549 cells, suggesting that PPQ-B may also attenuate the inflammatory responses caused by IAV infection. ppq-b 0-5 interleukin 6 Homo sapiens 85-89 28509078-9 2017 Vitamin D treatment reduced IL-6 level after 16 weeks (p = 0.027). Vitamin D 0-9 interleukin 6 Homo sapiens 28-32 28730070-9 2017 Curcumin at 5-20 micromol/L significantly inhibited UVB-induced secretion of IL-6 and IL-8 by limbus epithelial cells in a dose-dependent manner; while curcumin alone did not affect the secretion of IL-6 and IL-8. Curcumin 0-8 interleukin 6 Homo sapiens 77-81 28808406-9 2017 RESULTS: Peimine inhibited the production of pro-inflammatory cytokines, such as IL-6, IL-8, and TNF-alpha. verticine 9-16 interleukin 6 Homo sapiens 81-85 28808406-13 2017 SUMMARY: Peimine inhibited the production of pro-inflammatory cytokines, such as IL-6, IL-8, and TNF-alphaPeimine reduced MAPKs phosphorylation and the nuclear NF-kappaB expression in PMACI-induced HMC-1Peimine decreased PCA reactions in ratsPeimine has anti-allergic effect through regulation of pro-inflammatory mechanism on mast cell. verticine 9-16 interleukin 6 Homo sapiens 81-85 28665978-9 2017 Our results demonstrated testosterone not only suppressed the invasion and colonization of UPEC, but also inhibited the expression of pro-inflammatory IL-1beta, IL-6 and IL-8 cytokines expression induced by UPEC in a dose-dependent manner. Testosterone 25-37 interleukin 6 Homo sapiens 161-165 29285030-10 2017 Resveratrol significantly inhibited LPS-induced IL-6 and IL-8 secretion by HGFs, but silymarin did not show such a significant effect. Resveratrol 0-11 interleukin 6 Homo sapiens 48-52 28665937-8 2017 Treatment with 25 or 1,25 vitamin D decreased IL-6 and TLR9. Vitamin D 26-35 interleukin 6 Homo sapiens 46-50 28665937-9 2017 CYP24a1 silencing plus treatment with 25 and/or 1,25 vitamin D had an additional reduction effect on IL-6, IFN-gamma, TLR7 and TLR9 expression. Vitamin D 53-62 interleukin 6 Homo sapiens 101-105 28730070-9 2017 Curcumin at 5-20 micromol/L significantly inhibited UVB-induced secretion of IL-6 and IL-8 by limbus epithelial cells in a dose-dependent manner; while curcumin alone did not affect the secretion of IL-6 and IL-8. Curcumin 0-8 interleukin 6 Homo sapiens 199-203 28730070-10 2017 The upregulation of NF-kappaB and MAPK pathways induced by UVB treatment was significantly inhibited by curcumin, suggesting that NF-kappaB and MAPK pathways are involved in the inhibitory effect of curcumin on UVB-induced production of IL-6 and IL-8. Curcumin 104-112 interleukin 6 Homo sapiens 237-241 28730070-10 2017 The upregulation of NF-kappaB and MAPK pathways induced by UVB treatment was significantly inhibited by curcumin, suggesting that NF-kappaB and MAPK pathways are involved in the inhibitory effect of curcumin on UVB-induced production of IL-6 and IL-8. Curcumin 199-207 interleukin 6 Homo sapiens 237-241 28721153-8 2017 Lower iron concentration was associated with higher concentrations of hsCRP, IL-6 and fibrinogen. Iron 6-10 interleukin 6 Homo sapiens 77-96 28388577-3 2017 Repression of miR-204 was required for IL-6-induced cisplatin (cDDP) resistance. Cisplatin 52-61 interleukin 6 Homo sapiens 39-43 28388577-3 2017 Repression of miR-204 was required for IL-6-induced cisplatin (cDDP) resistance. Cisplatin 63-67 interleukin 6 Homo sapiens 39-43 28476620-8 2017 We found that the high level of Gm4419 promoted the phosphorylation of IkappaBalpha by physically associating with IkappaBalpha, therefore, led to increased nucleus NF-kappaB levels for the transcriptional activation of TNF-alpha, IL-1beta and IL-6. gm4419 32-38 interleukin 6 Homo sapiens 244-248 28408139-7 2017 Both mRNA and protein expression levels of the pro-inflammatory cytokines, interleukin-1beta (IL-1beta), IL-6 and, tumor necrosis factor-alpha (TNF-alpha) which were increased after induction with H2O2, could be attenuated by melatonin. Hydrogen Peroxide 197-201 interleukin 6 Homo sapiens 105-109 28729771-7 2017 Moreover, in vitro cell culture experiments revealed the expression alternations of IL-6, MAPK14, JUN, CDK5 and CAMK2A exposed to TPF treatment by qRT-PCR, whilst providing an insight into the mechanism underlying TPF chemotherapeutic response in HSCC. TPF 130-133 interleukin 6 Homo sapiens 84-88 28328181-3 2017 Recent advances in molecular understanding of iron metabolism provide strong evidence that immune mediators, such as IL-6, lead to hepcidin-induced hypoferremia, iron sequestration, and decreased iron availability for erythropoiesis. Iron 162-166 interleukin 6 Homo sapiens 117-121 28328181-3 2017 Recent advances in molecular understanding of iron metabolism provide strong evidence that immune mediators, such as IL-6, lead to hepcidin-induced hypoferremia, iron sequestration, and decreased iron availability for erythropoiesis. Iron 162-166 interleukin 6 Homo sapiens 117-121 28466560-0 2017 Bisphenol A triggers proliferation and migration of laryngeal squamous cell carcinoma via GPER mediated upregulation of IL-6. bisphenol A 0-11 interleukin 6 Homo sapiens 120-124 28466560-6 2017 Among various chemokines tested, the expression of IL-6 was significantly increased in LSCC cells treated with BPA for 24 hours. bisphenol A 111-114 interleukin 6 Homo sapiens 51-55 28466560-7 2017 Neutralization antibody of IL-6 or si-IL-6 can attenuate BPA-induced proliferation and migration of LSCC cells. bisphenol A 57-60 interleukin 6 Homo sapiens 27-31 28466560-7 2017 Neutralization antibody of IL-6 or si-IL-6 can attenuate BPA-induced proliferation and migration of LSCC cells. bisphenol A 57-60 interleukin 6 Homo sapiens 38-42 28466560-8 2017 Targeted inhibition of G protein-coupled estrogen receptor, while not estrogen receptor (ERalpha), abolished BPA-induced IL-6 expression, proliferation, and migration of LSCC cells. bisphenol A 109-112 interleukin 6 Homo sapiens 121-125 28466560-9 2017 The increased IL-6 can further activate its downstream signal molecule STAT3, which was evidenced by the results of increased phosphorylation and nuclear translocation of STAT3, while si-IL-6 and si-GPER can both reverse BPA-induced activation of STAT3. bisphenol A 221-224 interleukin 6 Homo sapiens 14-18 28466560-9 2017 The increased IL-6 can further activate its downstream signal molecule STAT3, which was evidenced by the results of increased phosphorylation and nuclear translocation of STAT3, while si-IL-6 and si-GPER can both reverse BPA-induced activation of STAT3. bisphenol A 221-224 interleukin 6 Homo sapiens 187-191 28466560-10 2017 Collectively, our present study revealed that BPA can trigger the progression of LSCC via GPER-mediated upregulation of IL-6. bisphenol A 46-49 interleukin 6 Homo sapiens 120-124 28529032-0 2017 Synergistic Cytotoxicity of Lenalidomide and Dexamethasone in Mantle Cell Lymphoma via Cereblon-dependent Targeting of the IL-6/STAT3/PI3K Axis. Dexamethasone 45-58 interleukin 6 Homo sapiens 123-127 28529032-2 2017 Cereblon is probably targeted by both lenalidomide and dexamethasone, which leads to synergistic cytotoxicity in MCL by inhibiting the interleukin-6/signal transducer and activator of transcription 3 (IL-6/STAT3), phosphatidylinositol 3-kinase (PI3K)/AKT and AKT2/Forkhead box O3 (FOXO3A)/BCL2-like 11 (BIM) pathways. Dexamethasone 55-68 interleukin 6 Homo sapiens 201-205 28328181-3 2017 Recent advances in molecular understanding of iron metabolism provide strong evidence that immune mediators, such as IL-6, lead to hepcidin-induced hypoferremia, iron sequestration, and decreased iron availability for erythropoiesis. Iron 46-50 interleukin 6 Homo sapiens 117-121 28276734-5 2017 In addition, we also showed that 6-hydroxyrubiadin inhibited the expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 in phorbol myristate acetate (PMA)-primed U937 and RAW 264.7 cells. Tetradecanoylphorbol Acetate 149-174 interleukin 6 Homo sapiens 141-145 28276734-5 2017 In addition, we also showed that 6-hydroxyrubiadin inhibited the expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 in phorbol myristate acetate (PMA)-primed U937 and RAW 264.7 cells. Tetradecanoylphorbol Acetate 176-179 interleukin 6 Homo sapiens 141-145 28248417-7 2017 In Cox proportional hazards models, each one standard deviation increase in baseline log-malondialdehyde levels predicted incident falls (Hazard ratio (HR) adjusted for age, gender, education, comorbidity count, medications, log-IL-6 levels, prior falls, depressive symptoms, cognitive status, gait velocity, and balance 1.53, 95% CI 1.11-2.16). Malondialdehyde 89-104 interleukin 6 Homo sapiens 229-233 28504650-3 2017 Here we found that in response to hyperglycemia, neutrophil-derived S100 calcium-binding proteins A8/A9 (S100A8/A9) interact with the receptor for advanced glycation end products (RAGE) on hepatic Kupffer cells, resulting in increased production of IL-6, a pleiotropic cytokine that is implicated in inflammatory thrombocytosis. Calcium 73-80 interleukin 6 Homo sapiens 249-253 28429008-6 2017 We found that the resveratrol analogues also significantly inhibited Akt and MAPK signalling and reduced the migration of IL-6 and EGF-treated cells. Resveratrol 18-29 interleukin 6 Homo sapiens 122-126 28561752-3 2017 Importantly, both AR-V7-induced NF-kappaB activation and IL-6 gene transcription in LNCaP and 22Rv1 cells could be inhibited by melatonin. Melatonin 128-137 interleukin 6 Homo sapiens 57-61 27576172-8 2017 When HBSMCs were subjected to 200-300 cm H2 O pressure for 2-24 h in vitro, the expressions of IL-6 and RANTES were significantly increased. Water 41-45 interleukin 6 Homo sapiens 95-99 27576172-11 2017 When cells were treated with 1 muM acetylcholine for 6 h, a significant increase in IL-6 mRNA expression was detected. Acetylcholine 35-48 interleukin 6 Homo sapiens 84-88 27576172-12 2017 Acetylcholine also enhanced pressure-induced phospho-NFkappaB p65 and IL-6 protein expression. Acetylcholine 0-13 interleukin 6 Homo sapiens 70-74 28570653-6 2017 RESULTS: AIT combined with short-term TOFA administration was significantly more effective in suppressing total cell and eosinophil infiltration into the lung, local cytokine production including IL-1beta and CXCL1 and showed a trend for the reduction of IL-4, IL-13, TNF-alpha and IL-6 compared to AIT alone. tofacitinib 38-42 interleukin 6 Homo sapiens 282-286 28570653-7 2017 Furthermore, TOFA co-administration significantly reduced systemic IL-6, IL-1beta and OVA-specific IgE levels and induced IgG1 to the same extent as AIT alone. tofacitinib 13-17 interleukin 6 Homo sapiens 67-71 28539592-7 2017 Furthermore, atorvastatin was able to block the induction of interleukins IL-6 and IL-8 triggered by pathologic stimuli relevant to AMD, such as cholesterol crystals and ox-LDL. Atorvastatin 13-25 interleukin 6 Homo sapiens 74-78 28539592-7 2017 Furthermore, atorvastatin was able to block the induction of interleukins IL-6 and IL-8 triggered by pathologic stimuli relevant to AMD, such as cholesterol crystals and ox-LDL. Cholesterol 145-156 interleukin 6 Homo sapiens 74-78 28486961-6 2017 Heparin reduced the expression of pro-inflammatory markers (TNF-alpha and IL-6) in hAM and deactivated the NF-kss pathway in hATII, diminishing the expression of IRAK1 and MyD88 and their effectors, IL-6, MCP-1 and IL-8. Heparin 0-7 interleukin 6 Homo sapiens 74-78 28270510-0 2017 Down-regulation of Forkhead box protein A1 (FOXA1) leads to cancer stem cell-like properties in tamoxifen-resistant breast cancer cells through induction of interleukin-6. Tamoxifen 96-105 interleukin 6 Homo sapiens 157-170 28500309-5 2017 Resveratrol reduced sFlt-1, sFlt-1 e15a and soluble endoglin secretion from primary trophoblasts and HUVECs and reduced mRNA expression of pro-inflammatory molecules NFkappaB, IL-6 and IL-1beta in trophoblasts. Resveratrol 0-11 interleukin 6 Homo sapiens 176-180 28181858-9 2017 TNFalpha stimulation increased expression of IL-6 at both RNA and protein level as well as upregulated COX2 gene expression and PTGES1.Stimulation with both INFgamma and TNFalpha resulted in significant increase in PGE2 levels in cell culture medium. Dinoprostone 215-219 interleukin 6 Homo sapiens 45-49 28486961-6 2017 Heparin reduced the expression of pro-inflammatory markers (TNF-alpha and IL-6) in hAM and deactivated the NF-kss pathway in hATII, diminishing the expression of IRAK1 and MyD88 and their effectors, IL-6, MCP-1 and IL-8. Heparin 0-7 interleukin 6 Homo sapiens 199-203 28473707-7 2017 Among the strongest changes was also induction of IL6 in resistant cells and the expression was further increased in response to cisplatin. Cisplatin 129-138 interleukin 6 Homo sapiens 50-53 28467474-0 2017 Tonic suppression of PCAT29 by the IL-6 signaling pathway in prostate cancer: Reversal by resveratrol. Resveratrol 90-101 interleukin 6 Homo sapiens 35-39 28467474-8 2017 In addition, we show that resveratrol is a potent stimulator of PCAT29 expression under basal condition and reversed the down regulation of this lncRNA by IL-6. Resveratrol 26-37 interleukin 6 Homo sapiens 155-159 28288823-13 2017 Upregulation of cadmium-induced IL-6 was inhibited by U0126 and SC-514, but not SB203580. Cadmium 16-23 interleukin 6 Homo sapiens 32-36 28467450-9 2017 We further observed that UVB-induced expression of TNF-alpha, IL6, IL-10, MMP-2 and MMP-9 was modulated by linalool treatment in HDFa cells. linalool 107-115 interleukin 6 Homo sapiens 62-65 28464004-0 2017 Vitamin D deficiency is associated with IL-6 levels and monocyte activation in HIV-infected persons. Vitamin D 0-9 interleukin 6 Homo sapiens 40-44 28464004-12 2017 In fully adjusted models, vitamin D associations with abnormal biomarker levels persisted for IL-6 levels and CX3CR1+ and CCR2+ phenotypes. Vitamin D 26-35 interleukin 6 Homo sapiens 94-98 27768523-6 2017 Acetaminophen and ibuprofen were used to block the effect of IL-6 at a central and peripheral level, respectively. Ibuprofen 18-27 interleukin 6 Homo sapiens 61-65 27917510-9 2017 N-acetyl-l-cysteine suppressed MeHg-induced activation of IL-6 and IL-8 mRNA expression in U937 macrophages, indicating the effectiveness of N-acetyl-l-cysteine as a therapeutic drug in MeHg-induced inflammation. Acetylcysteine 0-19 interleukin 6 Homo sapiens 58-62 27917510-9 2017 N-acetyl-l-cysteine suppressed MeHg-induced activation of IL-6 and IL-8 mRNA expression in U937 macrophages, indicating the effectiveness of N-acetyl-l-cysteine as a therapeutic drug in MeHg-induced inflammation. Acetylcysteine 141-160 interleukin 6 Homo sapiens 58-62 28288823-0 2017 Cadmium-induced IL-6 and IL-8 expression and release from astrocytes are mediated by MAPK and NF-kappaB pathways. Cadmium 0-7 interleukin 6 Homo sapiens 16-20 28288823-3 2017 In the peripheral system, cadmium promotes interleukin-6 (IL-6) and IL-8 production and release. Cadmium 26-33 interleukin 6 Homo sapiens 43-56 28288823-3 2017 In the peripheral system, cadmium promotes interleukin-6 (IL-6) and IL-8 production and release. Cadmium 26-33 interleukin 6 Homo sapiens 58-62 28288823-6 2017 Herein, the effects of non-toxic concentrations of cadmium on the production of IL-6 and IL-8 and the underlying mechanisms were investigated. Cadmium 51-58 interleukin 6 Homo sapiens 80-84 28288823-15 2017 In conclusion, non-toxic concentrations of cadmium can stimulate IL-6 and IL-8 release through MAPK phosphorylation and NF-kappaB activation. Cadmium 43-50 interleukin 6 Homo sapiens 65-69 28288823-10 2017 IL-6 and IL-8 mRNA levels and secretion increased in dose- and time-dependent manners post cadmium exposure. Cadmium 91-98 interleukin 6 Homo sapiens 0-4 28288823-16 2017 Suppressing IL-6 and IL-8 production could be novel approaches to prevent cadmium-induced angiogenesis in gliomas and inflammation in the brain. Cadmium 74-81 interleukin 6 Homo sapiens 12-16 27701117-7 2017 Exogenous SMase and IL-6 mimicked the effects of LPS on endothelial dysfunction, HPV failure and hyperresponsiveness to serotonin in PA; whereas blockade of aSMase or IL-6 prevented LPS-induced effects. Serotonin 120-129 interleukin 6 Homo sapiens 20-24 27651177-12 2017 Interleukin 6 production was 75% higher in the estradiol than progesterone environment. Estradiol 47-56 interleukin 6 Homo sapiens 0-13 27651177-12 2017 Interleukin 6 production was 75% higher in the estradiol than progesterone environment. Progesterone 62-74 interleukin 6 Homo sapiens 0-13 27651177-13 2017 The progesterone environment produced IL-6 levels twice that observed in HF and combined estrogen-progesterone environments. Progesterone 4-16 interleukin 6 Homo sapiens 38-42 28262601-0 2017 IL-6 and TNF-alpha in unmedicated adults with ADHD: Relationship to cortisol awakening response. Hydrocortisone 68-76 interleukin 6 Homo sapiens 0-4 28262601-10 2017 Negative associations between IL-6 (r=-0.386, p=0.020), TNF-alpha (r=-0.372, p=0.023) and cortisol awakening response were found in the inattentive subtype, whereas no association was seen in the combined subtype. Hydrocortisone 90-98 interleukin 6 Homo sapiens 30-34 28420398-7 2017 RESULTS: Dexamethasone significantly inhibited NTHi induced TNF-alpha, IL-6 and IL-10 from COPD macrophages but, CXCL8 was not suppressed. Dexamethasone 9-22 interleukin 6 Homo sapiens 71-75 28503530-7 2017 When compared the changes between groups (postvalues minus prevalues), there was lower glucose in CAF group when compared to CHO group (CAF= 5.0+-10.4 vs. CHO=27.8+-20 vs. P=15.1+-14, P=0.031) and higher IL-6 levels (CAF=11.9+-9.2 vs. CHO=-2.4+-1.7 vs. P=4.3+- 11.7, P=0.017). Glucose 87-94 interleukin 6 Homo sapiens 204-208 28088612-10 2017 When we compared the gene expression for paired mucosa in the immunosuppressive treated group with the 5-ASA treated group we observed opposite changes in IL-6 and TGFbeta1 expression. 5-Aminosalicylic acid 103-108 interleukin 6 Homo sapiens 155-159 26874912-6 2017 RESULTS: Anti-inflammatory cytokines (interleukin-6 and interleukin-18) were increased in the fasting state and/or decreased in some women during the oral glucose tolerance test, as opposed to inflammatory mediators such as macrophage migration inhibitory factor and matrix metallopeptidase-9 that increased during the oral glucose tolerance test especially in subjects with weight excess. Glucose 155-162 interleukin 6 Homo sapiens 38-51 26874912-6 2017 RESULTS: Anti-inflammatory cytokines (interleukin-6 and interleukin-18) were increased in the fasting state and/or decreased in some women during the oral glucose tolerance test, as opposed to inflammatory mediators such as macrophage migration inhibitory factor and matrix metallopeptidase-9 that increased during the oral glucose tolerance test especially in subjects with weight excess. Glucose 324-331 interleukin 6 Homo sapiens 38-51 28420169-0 2017 Ultrasensitive Label-Free Sensing of IL-6 Based on PASE Functionalized Carbon Nanotube Micro-Arrays with RNA-Aptamers as Molecular Recognition Elements. Carbon 71-77 interleukin 6 Homo sapiens 37-41 28420169-1 2017 This study demonstrates the rapid and label-free detection of Interleukin-6 (IL-6) using carbon nanotube micro-arrays with aptamer as the molecular recognition element. Carbon 89-95 interleukin 6 Homo sapiens 62-75 28420169-1 2017 This study demonstrates the rapid and label-free detection of Interleukin-6 (IL-6) using carbon nanotube micro-arrays with aptamer as the molecular recognition element. Carbon 89-95 interleukin 6 Homo sapiens 77-81 28211306-0 2017 Ex vivo all-trans retinoic acid modulates NO production and regulates IL-6 effect during rheumatoid arthritis: a study in Algerian patients. Tretinoin 18-31 interleukin 6 Homo sapiens 70-74 28233699-7 2017 CD upregulated renal cytokine levels (TNF-alpha, IL-6), nuclear NF-kappaB (p65) expression, NF-kappaB-DNA-binding activity, and MPO activity, which were significantly downregulated upon SA pretreatment. Cadmium 0-2 interleukin 6 Homo sapiens 49-53 28211306-5 2017 Then, we assessed the possible regulatory effect of ATRA on NO production induced by IL-6. Tretinoin 52-56 interleukin 6 Homo sapiens 85-89 28211306-12 2017 Interestingly, it seems that NO production mediated by IL-6 on PBMCs of RA patients is downregulated by ATRA. Tretinoin 104-108 interleukin 6 Homo sapiens 55-59 28211306-13 2017 Taken together, our results highlight the immunomodulatory effect of ATRA on NO pathway in RA patients and its possible role in regulating IL-6-mediated NO production. Tretinoin 69-73 interleukin 6 Homo sapiens 139-143 28019133-8 2017 A relationship was detected between H score, FSH, LH, total testosterone, HDL-C and TG levels and CG + GG genotypes of IL-6. Testosterone 60-72 interleukin 6 Homo sapiens 119-123 28044237-7 2017 D-lactates and LPS levels were weakly associated with IL6 (R = 0.175; p = 0.03, and R = 0.241; p = 0.003). Lactic Acid 0-10 interleukin 6 Homo sapiens 54-57 28044237-10 2017 CONCLUSION: The weak association between plasma D-lactate, LPS and IL6 levels indicates that intestinal flora overgrowth or increased intestinal permeability contributes very slightly to the chronic inflammation development in HD patients. Lactic Acid 48-57 interleukin 6 Homo sapiens 67-70 27796050-7 2017 Immunohistochemical staining of the distal femur demonstrated that %TNF-alpha+ , %IL-6+ , %RANKL+ , and %OPG+ osteocytes were elevated in cancellous bone in TNBS animals compared to vehicle. Trinitrobenzenesulfonic Acid 157-161 interleukin 6 Homo sapiens 82-86 28019133-8 2017 A relationship was detected between H score, FSH, LH, total testosterone, HDL-C and TG levels and CG + GG genotypes of IL-6. Thioguanine 84-86 interleukin 6 Homo sapiens 119-123 28195425-5 2017 Meanwhile, PEG and COOH modifications can ameliorate the activation of IL-6-hepcidin signaling. Polyethylene Glycols 11-14 interleukin 6 Homo sapiens 71-75 27397896-8 2017 RESULTS: High glucose stimulated a significant increase in the production of IL-6 and IL-8 by HGFs compared with normal glucose. Glucose 14-21 interleukin 6 Homo sapiens 77-81 28454469-12 2017 Furthermore, the baicalein-cisplatin combination suppressed the secretion of interleukin-6, and baicalein and the combination of baicalein cisplatin decreased the secretion of tumor necrosis factor-alpha of A549 cells. Cisplatin 27-36 interleukin 6 Homo sapiens 77-90 27827528-9 2017 Moreover, PBSu and PBSu/TCP significantly suppressed the expression of IL-1beta and IL-6 genes by 15-35% and 21-26%, respectively. bionole 10-14 interleukin 6 Homo sapiens 84-88 27827528-9 2017 Moreover, PBSu and PBSu/TCP significantly suppressed the expression of IL-1beta and IL-6 genes by 15-35% and 21-26%, respectively. bionole 19-23 interleukin 6 Homo sapiens 84-88 28195425-5 2017 Meanwhile, PEG and COOH modifications can ameliorate the activation of IL-6-hepcidin signaling. Carbonic Acid 19-23 interleukin 6 Homo sapiens 71-75 32454590-7 2017 Results: Adenosine-5"-N-ethyluronamide (NECA), a stable adenosine analogue, concentration- and time-dependently stimulates IL-6 gene expression in skeletal muscle cells. Adenosine 9-18 interleukin 6 Homo sapiens 123-127 32454590-7 2017 Results: Adenosine-5"-N-ethyluronamide (NECA), a stable adenosine analogue, concentration- and time-dependently stimulates IL-6 gene expression in skeletal muscle cells. Adenosine 56-65 interleukin 6 Homo sapiens 123-127 32454590-9 2017 By using cyclic adenosine monophosphate (cAMP)-arising reagent forskolin, cAMP is found to be involved in the up-regulation of IL-6 induction. Adenosine 16-25 interleukin 6 Homo sapiens 127-131 32454590-9 2017 By using cyclic adenosine monophosphate (cAMP)-arising reagent forskolin, cAMP is found to be involved in the up-regulation of IL-6 induction. Cyclic AMP 41-45 interleukin 6 Homo sapiens 127-131 32454590-9 2017 By using cyclic adenosine monophosphate (cAMP)-arising reagent forskolin, cAMP is found to be involved in the up-regulation of IL-6 induction. Cyclic AMP 74-78 interleukin 6 Homo sapiens 127-131 32454590-10 2017 Conclusion: Here, a novel relationship between adenosine and IL-6 up-regulation has been demonstrated for the first time; IL-6 up-regulation induced by NECA is mediated by adenosine A2B receptor activation in skeletal muscle and is dependent on mainly a cAMP pathway. Adenosine 47-56 interleukin 6 Homo sapiens 61-65 32454590-10 2017 Conclusion: Here, a novel relationship between adenosine and IL-6 up-regulation has been demonstrated for the first time; IL-6 up-regulation induced by NECA is mediated by adenosine A2B receptor activation in skeletal muscle and is dependent on mainly a cAMP pathway. Adenosine 47-56 interleukin 6 Homo sapiens 122-126 32454590-10 2017 Conclusion: Here, a novel relationship between adenosine and IL-6 up-regulation has been demonstrated for the first time; IL-6 up-regulation induced by NECA is mediated by adenosine A2B receptor activation in skeletal muscle and is dependent on mainly a cAMP pathway. Cyclic AMP 254-258 interleukin 6 Homo sapiens 122-126 28344983-10 2017 Challenge with bile acids at physiological levels also led to a significant increase in the release of IL-8 and IL6 from BEAS-2B. Bile Acids and Salts 15-25 interleukin 6 Homo sapiens 112-115 28358370-7 2017 Moreover, incubation with autophagy inducer trehalose restored the capacity of phagocytosis, IL-6 and TNF-alpha secretion, and MHC-II expression in macrophages. Trehalose 44-53 interleukin 6 Homo sapiens 93-97 28345531-7 2017 Catechins also reduce platelet adhesion, lower the concentration of C-reactive protein and tumor necrosis factor alpha and interleukin-6. Catechin 0-9 interleukin 6 Homo sapiens 123-136 28300826-5 2017 In this paradigm, activated glial cells are the source of IL-6, which was essential in the iron overload-activated apoptosis of neurons. Iron 91-95 interleukin 6 Homo sapiens 58-62 28300826-7 2017 Together, our data are consistent with a model whereby inflammation initiates an intercellular signaling cascade in which activated microglia, through IL-6 signaling, stimulate astrocytes to release hepcidin which, in turn, signals to neurons, via hepcidin, to prevent their iron release. Iron 275-279 interleukin 6 Homo sapiens 151-155 28115165-5 2017 We found that IL-6 signaling via phosphorylated Stat3 induced gefitinib resistance as repressing transcription of Smad3, whereas TGF-beta enhanced gefitinib sensitivity as activating transcription of Smad3 in HCC827 cells with gefitinib-sensitizing EGFR mutation. Gefitinib 62-71 interleukin 6 Homo sapiens 14-18 28273917-4 2017 Results demonstrate that cap (0.1-25 microM) significantly (p < 0.05) inhibited the release of prostaglandin E2 (PGE2), 8-iso-PGF2alpha, and differentially regulated the levels of cytokines (TNF-alpha, IL-6 & IL-1beta). Capsaicin 25-28 interleukin 6 Homo sapiens 205-209 28335413-11 2017 COS improved biochemical indexes and reduced the levels of interleukin (IL)-6 and tumor necrosis factor (TNF) alpha. carbonyl sulfide 0-3 interleukin 6 Homo sapiens 59-77 28282033-5 2017 At concentration of the dual PI3Kdelta/gamma inhibitor duvelisib, which can be achieved in vivo we saw a decrease in AKT phosphorylation at s473 after tumour activation by bone marrow stromal cells (BMSC) and interleukin-6. duvelisib 55-64 interleukin 6 Homo sapiens 209-222 28278187-6 2017 Treatment with resveratrol significantly reduced the expression and secretion of pro-inflammatory cytokines IL-6, IL-1alpha, IL-1beta and pro-inflammatory chemokines IL-8 and MCP-1 in human placenta and omental and subcutaneous adipose tissue. Resveratrol 15-26 interleukin 6 Homo sapiens 108-112 28204817-0 2017 Resveratrol inhibits the IL-1beta-induced expression of MMP-13 and IL-6 in human articular chondrocytes via TLR4/MyD88-dependent and -independent signaling cascades. Resveratrol 0-11 interleukin 6 Homo sapiens 67-71 27894955-6 2017 Among signaling pathways related to T-ICs, IL-6/STAT3 was identified to be responsible for the elevation of glucose uptake in liver T-ICs under glucose limitation. Glucose 108-115 interleukin 6 Homo sapiens 43-47 27894955-6 2017 Among signaling pathways related to T-ICs, IL-6/STAT3 was identified to be responsible for the elevation of glucose uptake in liver T-ICs under glucose limitation. Glucose 144-151 interleukin 6 Homo sapiens 43-47 27894955-9 2017 Our findings suggest that blocking IL-6/STAT3-mediated preferential glucose uptake might be exploited for novel therapeutic targets during hepatocellular carcinoma (HCC) progression. Glucose 68-75 interleukin 6 Homo sapiens 35-39 28073126-5 2017 Results: Our results demonstrated that high levels of IL6 are associated with altered glucose levels in the WAT (p=0.01). Glucose 86-93 interleukin 6 Homo sapiens 54-57 28149010-0 2017 Association of Interleukin-6 and Myeloperoxidase with Insulin Resistance in Impaired Fasting Glucose Subjects. Glucose 93-100 interleukin 6 Homo sapiens 15-28 28259141-5 2017 RESULTS: In the sevoflurane group, the plasma concentrations of cTnI and CK-MB from Tl to T4 and the levels of IL-6 and IL-10 from T1 to T2 were lower than those in the propofol group. Sevoflurane 16-27 interleukin 6 Homo sapiens 111-115 28303243-0 2017 High-Density Lipoprotein Subfractions and Cholesterol Efflux Capacity Are Not Affected by Supervised Exercise but Are Associated with Baseline Interleukin-6 in Patients with Peripheral Artery Disease. Cholesterol 42-53 interleukin 6 Homo sapiens 143-156 27995612-8 2017 IL-15 and IL-6 expression are stimulated by IFN-y and correlate with ROS levels in BM mononuclear cells. ros 69-72 interleukin 6 Homo sapiens 10-14 28400837-4 2017 IPE also enhanced IL-6 and TNF-alpha production in macrophages in the presence of lipopolysaccharide (LPS), although IPE alone did not induce cytokine production. ipe 0-3 interleukin 6 Homo sapiens 18-22 28013248-9 2017 The association between tryptophan oxidation and CNS inflammatory responses as measured by CSF interleukin 6 (IL-6) concentration supports a role of kynurenine metabolites in the inflammatory pathogenesis of late-stage HAT. Tryptophan 24-34 interleukin 6 Homo sapiens 110-114 27176565-6 2017 Under these conditions, dexamethasone is non-toxic and maintains the viability of chondrocytes exposed chronically to such cytokines as interleukin (IL) -1, IL-6, and tumor necrosis factor-alpha. Dexamethasone 24-37 interleukin 6 Homo sapiens 157-161 27787915-0 2017 Resveratrol inhibits IL-6-induced ovarian cancer cell migration through epigenetic up-regulation of autophagy. Resveratrol 0-11 interleukin 6 Homo sapiens 21-25 27787915-7 2017 On opposite, Resveratrol could counteract the IL-6 induction of cell migration in ovarian cancer cells through induction of autophagy in the cells at the migration front, which was paralleled by up-regulation of ARH-I and down-regulation of STAT3 expression. Resveratrol 13-24 interleukin 6 Homo sapiens 46-50 27655254-8 2017 NH4Cl also attenuated LPS-induced release of MCP-1, IL-6 and IL-10 in mono-cultured microglia. Ammonium Chloride 0-5 interleukin 6 Homo sapiens 52-56 27997269-8 2017 The presence of 250 nM TG significantly induced cytotoxicity, release of IL-6 and THP-1 monocyte adhesion (p < 0.01), but did not significantly affect intracellular ROS or release of TNFalpha (p > 0.05). Thapsigargin 23-25 interleukin 6 Homo sapiens 73-77 28063793-4 2017 Proteins/mRNAs (StAR, cholesterol side chain cleavage enzyme, SF-1, AP-1) and SPA were increased by IL-6 (60min 1-50ng/mL IL-6; 5ng/mL IL-6 30-120min P<0.05). Cholesterol 22-33 interleukin 6 Homo sapiens 100-104 28245605-7 2017 Furthermore, TTB selectively inhibited STAT3 activation, which resulted in a reduction in cyclin D1, MMP-9, survivin, VEGF, and IL-6. Thenoyltrifluoroacetone 13-16 interleukin 6 Homo sapiens 128-132 29250282-6 2017 Results: Immediate post ablation levels of inflammatory cytokines were lower in the steroid group when compared to the placebo group; IL-6: 9.0 +-7 vs 15.8 +-13 p=0.031; IL-8: 10.5 +-9 vs 15.3 +-8; p=0.047 respectively. Steroids 84-91 interleukin 6 Homo sapiens 134-138 28240322-4 2017 Pre-treatment of microglia with 30-60 muM ZnCl2 resulted in dose-dependent increases in interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNFalpha) secretion when M1 activation was induced by lipopolysaccharide administration. zinc chloride 42-47 interleukin 6 Homo sapiens 119-132 28240322-4 2017 Pre-treatment of microglia with 30-60 muM ZnCl2 resulted in dose-dependent increases in interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNFalpha) secretion when M1 activation was induced by lipopolysaccharide administration. zinc chloride 42-47 interleukin 6 Homo sapiens 134-138 28241819-9 2017 A prominent increase in the pro-inflammatory genes IL-6 and TNF-alpha was observed when cells were cultured with PLGA/Ag-TCP compared to the other groups. N-(3,4,5-trichlorophenyl)succinimide 121-124 interleukin 6 Homo sapiens 51-55 28109867-5 2017 More importantly, the depletion of MDSC via the administration of anti-Gr-1 antibody or the blockade of IL-6 signaling sensitized 5-FU-resistant H22 hepatoma to chemotherapy in the immunocompetent C57BL/6N mice. Fluorouracil 130-134 interleukin 6 Homo sapiens 104-108 28251074-8 2017 LPS at concentrations of 300 ng/mL for 1h significantly stimulated the mRNA expression of IL-8, IL-6, IL-1beta, TNF-alpha, and TGF-beta in HCECs, while the stimulation effects were significantly inhibited by AA (20 micromol/L). Hydrogen 39-41 interleukin 6 Homo sapiens 96-100 28260924-7 2017 In addition, circulating interleukin (IL)-6 was significantly decreased, especially in patients sensitive to gefitinib (P<0.001). Gefitinib 109-118 interleukin 6 Homo sapiens 25-43 28004910-8 2017 Moreover, cellular drug efficacy of AT-loaded nanoparticles in preventing macrophage-derived foam cell formation and inflammation such as intracellular lipid deposition, cholesterol esters content, DiI-oxLDL uptake, cholesterol efflux, and secretion of TNF-alpha, IL-6, and IL-10 was much better than that of the drug-free nanoparticles, consistent with the results of cellular uptake study. Atorvastatin 36-38 interleukin 6 Homo sapiens 264-268 28182789-7 2017 Renal levels of TNF-alpha and IL-6, two important inflammatory cytokines, were also upregulated by cisplatin. Cisplatin 99-108 interleukin 6 Homo sapiens 30-34 28192516-0 2017 Correction: Atorvastatin, Losartan and Captopril Lead to Upregulation of TGF-beta, and Downregulation of IL-6 in Coronary Artery Disease and Hypertension. Atorvastatin 12-24 interleukin 6 Homo sapiens 105-109 28208810-10 2017 Moreover, by using Shp2 phosphatase mutants, phosphor-tyrosine mimicking, and deficiency mutants, we provided evidence that the phosphatase activity of Shp2 and its tyrosine phosphorylation, are necessary for the IL-6-induced downregulation of E-cadherin and the phosphorylation of Erk1/2. Tyrosine 165-173 interleukin 6 Homo sapiens 213-217 27998979-11 2017 Dexamethasone induces the recruitment of ACTN4 and GR to putative GREs in dexamethasone-transactivated promoters, SERPINE1, ANGPLT4, CCL20, and SAA1 as well as the NF-kappaB (p65) binding sites on GR-transrepressed promoters such as IL-1beta, IL-6, and IL-8 Taken together, our data establish ACTN4 as a transcriptional co-regulator that modulates both dexamethasone-transactivated and -transrepressed genes in podocytes. Dexamethasone 0-13 interleukin 6 Homo sapiens 243-247 27998979-11 2017 Dexamethasone induces the recruitment of ACTN4 and GR to putative GREs in dexamethasone-transactivated promoters, SERPINE1, ANGPLT4, CCL20, and SAA1 as well as the NF-kappaB (p65) binding sites on GR-transrepressed promoters such as IL-1beta, IL-6, and IL-8 Taken together, our data establish ACTN4 as a transcriptional co-regulator that modulates both dexamethasone-transactivated and -transrepressed genes in podocytes. Dexamethasone 74-87 interleukin 6 Homo sapiens 243-247 28153003-13 2017 In RT-qPCR results, aucubin could maintain ACAN and COL2A1 gene expressions, and prevent IL6 and MMP13 gene up-regulation induced by H2O2 and compression stimulations. Hydrogen Peroxide 133-137 interleukin 6 Homo sapiens 89-92 27769916-8 2017 Fibrinogen and IL-6 increased post-stress (p<=0.001 & 0.003) but TNFalpha was unchanged (p=0.09). Adenosine Monophosphate 56-59 interleukin 6 Homo sapiens 15-19 28035387-10 2017 Additionally, levels of IL-6 and IL-8 were significantly decreased by prednisone, ibuprofen and betamethasone. Ibuprofen 82-91 interleukin 6 Homo sapiens 24-28 28168393-9 2017 Further, alcohol-related increases (1.5-3.0 fold) were observed in the expression of hepatic cytokines (TNF-alpha, IL-1 beta, IL-6, IL-10) and other factors noted to be involved in the colonization of CRC cells including ICAM-1, CCL-2, CCL-7, MMP-2, and MMP-9. Alcohols 9-16 interleukin 6 Homo sapiens 126-130 27643869-5 2017 In addition, CsA increased production of inflammatory cytokines, including interleukin (IL)-1beta and IL-6, associated with an increase in nuclear levels of nuclear factor-kappaB (NF-kappaB) which also enhanced vascular permeability. Cyclosporine 13-16 interleukin 6 Homo sapiens 102-106 27838779-6 2017 RESULTS: Measures of systemic inflammation [C-reactive protein (CRP) and interleukin-6 (IL-6)] were higher in obese adults when compared to lean adults and tended to decrease with IBU (IL-6: p < 0.05; CRP: p = 0.14). Ibuprofen 180-183 interleukin 6 Homo sapiens 73-86 27838779-6 2017 RESULTS: Measures of systemic inflammation [C-reactive protein (CRP) and interleukin-6 (IL-6)] were higher in obese adults when compared to lean adults and tended to decrease with IBU (IL-6: p < 0.05; CRP: p = 0.14). Ibuprofen 180-183 interleukin 6 Homo sapiens 185-189 27918955-12 2017 After proper glycemic control, release of IL-1beta was increased and of IL-6 decreased; cells of patients with improved glycemic control responded better to LPS stimulation under increased concentrations of glucose. Glucose 207-214 interleukin 6 Homo sapiens 72-76 27709266-6 2017 Further analysis indicated that nicotine inhibited STAT3 activation in vivo and in IL-6 treated Caco-2 cells and Jurkat human T lymphocytes, in which miR-124 knockdown led to increased activation of STAT3. Nicotine 32-40 interleukin 6 Homo sapiens 83-87 27400413-5 2017 We identify PADI2 as one of the most highly upregulated transcripts in BMMSCs from both MGUS and MM patients, and that through its enzymatic deimination of histone H3 arginine 26, PADI2 activity directly induces the upregulation of interleukin-6 expression. Arginine 167-175 interleukin 6 Homo sapiens 232-245 27416847-1 2017 Objective Hepcidin regulates iron availability and may be responsible for the anemia of chronic disease because it is induced by interleukin-6. Iron 29-33 interleukin 6 Homo sapiens 129-142 28035387-13 2017 In conclusion, prednisone, ibuprofen and betamethasone may prevent OA by suppressing the expression of IL-6 and IL-8, subsequently inactivating NF-kappaB and STAT3 pathways, and ultimately, leading to decreased levels of collagen I, MMP-1, and MMP-13. Ibuprofen 27-36 interleukin 6 Homo sapiens 103-107 28035387-12 2017 In combination with IL-6 or IL-8, prednisone, ibuprofen and betamethasone significantly reduced the levels of collagen I, MMP-1 and MMP-13, and inactivated NF-kappaB and STAT3 pathways. Ibuprofen 46-55 interleukin 6 Homo sapiens 20-24 27574898-7 2017 In the SW1353 cell line model, zingerone efficiently suppressed the expression of TNF-alpha, interleukin-6, and interleukin-8 mRNA levels and tended to reduce the levels of both p38 and c-Jun N-terminal kinase phosphorylation. zingerone 31-40 interleukin 6 Homo sapiens 93-106 26869278-3 2017 METHODS: Human mesothelial cells (Met-5A) were incubated with different concentrations of glucose and mannitol, and the effect of glucose and mannitol on the expression of IL-6 was determined. Glucose 130-137 interleukin 6 Homo sapiens 172-176 26869278-8 2017 High glucose and mannitol could upregulate IL-6 mRNA expression and IL-6 secretion in mesothelial cells significantly, and there was no difference of its effect between high glucose and mannitol. Glucose 5-12 interleukin 6 Homo sapiens 43-47 26869278-8 2017 High glucose and mannitol could upregulate IL-6 mRNA expression and IL-6 secretion in mesothelial cells significantly, and there was no difference of its effect between high glucose and mannitol. Glucose 5-12 interleukin 6 Homo sapiens 68-72 26869278-13 2017 CONCLUSION: The present study might provide evidence that high glucose upregulates IL-6 synthesis in Met-5A cells, to some extent, depending on its osmolality and that IL-6 trans-signalling could induce VEGF synthesis partly dependent on the JAK/STAT3 pathway. Glucose 63-70 interleukin 6 Homo sapiens 83-87 28118826-8 2017 Concentrations of NAC >=300 muM inhibited the inflammatory response (release of IL-1beta, IL-8, and TNF-alpha) of human airways induced by the overnight stimulation with LPS, whereas lower concentrations of NAC (>=1 muM) were sufficient to reduce the release of IL-6 elicited by LPS. Acetylcysteine 18-21 interleukin 6 Homo sapiens 268-272 28118841-0 2017 Copper chelation and interleukin-6 proinflammatory cytokine effects on expression of different proteins involved in iron metabolism in HepG2 cell line. Iron 116-120 interleukin 6 Homo sapiens 21-34 28118841-4 2017 RESULTS: We show that copper deficiency and the inflammatory cytokine interleukin-6 have different effects on the expression of proteins involved in iron and copper metabolism such as the soluble and glycosylphosphtidylinositol anchored forms of ceruloplasmin, hepcidin, ferroportin1, transferrin receptor1, divalent metal transporter1 and H-ferritin subunit. Iron 149-153 interleukin 6 Homo sapiens 70-83 28069788-5 2017 While tapering steroid therapy, his serum PR3-ANCA levels; cerebrospinal fluid findings, including IL-6 levels; and symptoms improved. Steroids 15-22 interleukin 6 Homo sapiens 99-103 27835873-4 2017 6-OAP formed hydrogen bonds with Ser611/Ser613/Arg609 at the SH2 domain of STAT3 and inhibited the constitutive and interleukin-6-induced phosphorylated STAT3 (pSTAT3), leading to inhibitory effects on lung cancer cells and suppression of Skp2 transcription. Hydrogen 13-21 interleukin 6 Homo sapiens 116-129 28054602-0 2017 Identification of Guanosine 5"-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway. Iron 56-60 interleukin 6 Homo sapiens 139-152 28061809-12 2017 Increased maternal malondialdehyde plasma was associated with higher levels of IL-6 and IL-7 in the offspring. Malondialdehyde 19-34 interleukin 6 Homo sapiens 79-83 27871911-5 2017 In addition, we also showed that theaflavin-3,3"-digallate inhibited the expression of tumor necrosis factor alpha, interleukin -1 beta, and interleukin 6 in phorbol myristate acetate -primed U937 and RAW 264.7 cells. Tetradecanoylphorbol Acetate 158-183 interleukin 6 Homo sapiens 141-154 28659037-5 2017 We showed that myrcene decreased the production of ROS, MMP-1, MMP-3, and IL-6, and increased TGF-[Formula: see text]1 and type I procollagen secretions. myrcene 15-22 interleukin 6 Homo sapiens 74-78 28849490-7 2017 Treatment with Tau-Ribose significantly modulated the production of IL-8 and IL-6. tau-ribose 15-25 interleukin 6 Homo sapiens 77-81 28046113-10 2017 Treatment with butylated hydroxyanisole, a free radical scavenger, attenuated the ozone-induced increases in IL-6 expression in IL-1alpha-pretreated conjunctival epithelial cells. Butylated Hydroxyanisole 15-39 interleukin 6 Homo sapiens 109-113 28675894-0 2017 Low Oxygen Consumption is Related to a Hypomethylation and an Increased Secretion of IL-6 in Obese Subjects with Sleep Apnea-Hypopnea Syndrome. Oxygen 4-10 interleukin 6 Homo sapiens 85-89 28675894-5 2017 RESULTS: The analyzed interleukin 6 (IL6) gene cytosine phosphate guanine (CpG) islands showed a hypomethylation, while serum IL-6 was higher in the low compared to the high oxygen consumption group (p < 0.05). Oxygen 174-180 interleukin 6 Homo sapiens 37-40 28675894-5 2017 RESULTS: The analyzed interleukin 6 (IL6) gene cytosine phosphate guanine (CpG) islands showed a hypomethylation, while serum IL-6 was higher in the low compared to the high oxygen consumption group (p < 0.05). Oxygen 174-180 interleukin 6 Homo sapiens 126-130 27605567-9 2017 RESULTS: Absence of a minor allele in 2 IL6 SNPs was associated with fecal calprotectin ( p = .0222, p = .0429), length of stay ( p = .0158), SNAPPE-II ( p = .0497), weight gain ( p = .0272), and days on oxygen ( p = .0316). Oxygen 204-210 interleukin 6 Homo sapiens 40-43 28191453-0 2017 Anti-TNF-Mediated Modulation of Prohepcidin Improves Iron Availability in Inflammatory Bowel Disease, in an IL-6-Mediated Fashion. Iron 53-57 interleukin 6 Homo sapiens 108-112 28357403-15 2017 Prior atorvastatin treatment in patients with ischemic stroke was associated with a lower concentration of IL-6 and TNF-alpha and improved the outcome of VAP. Atorvastatin 6-18 interleukin 6 Homo sapiens 107-111 27749321-8 2017 The increments of serum omentin-1 levels with atorvastatin administration inversely correlated with changes in LDL cholesterol (r=-0.145, P=0.041), interleukin-6 (r=-0.162, P=0.023), and high-sensitivity C-reactive protein (r=-0.185, P=0.009) in patients with CAD. Atorvastatin 46-58 interleukin 6 Homo sapiens 148-161 27510419-7 2017 Four-day treatment with dextran sulphate sodium (DSS) triggered colon inflammation, as evidenced by an increase in local IL6 and mKC mRNA levels, but did not affect the gross architecture of colonic epithelium. dextran sulphate sodium 24-47 interleukin 6 Homo sapiens 121-124 29204094-4 2017 Material and methods: The aim of this study was to evaluate the possible relationship between polymorphisms: interleukin-1beta +3953 C>T, interleukin-6 -174 G>C and -596 G>A, tumour necrosis factor -308 G>A and interleukin-1RN VNTR 86bp and the occurrence of BPD in a population of 100 preterm infants born from singleton pregnancy, before 32+0 weeks of gestation, exposed to antenatal steroids therapy, and without congenital abnormalities. Steroids 398-406 interleukin 6 Homo sapiens 141-154 28680337-5 2017 Glutathione treatment decreased the serum levels of asparaginic acid transaminase, alanine aminotransferase, total bilirubin, total bile acids, haluronic acid, collagen IV, laminin, transforming growth factor-beta1, tumour necrosis factor-alpha, interleukin-6, and interleukin-8, compared with the control group. Glutathione 0-11 interleukin 6 Homo sapiens 246-259 28804534-6 2017 In addition, when infected by prominent periodontal pathogens, Porphyromonas gingivalis (ATCC 33277), rapamycin-pretreated groups decreased the expression of inflammatory cytokines (IL-6 and IL-8) compared with the control group. Sirolimus 102-111 interleukin 6 Homo sapiens 182-186 28652539-1 2017 In the current study, we examined the effects of LPS and inflammatory cytokines including IL-1beta, TNF-alpha, and IL-6 on the expression of ghrelin in MGN3-1 cells. Ghrelin 141-148 interleukin 6 Homo sapiens 115-119 29721026-8 2017 Preincubation of ozone at 50 mug/ml decreases IL-8, IL-6, and IL-1beta production by 50, 56, and 70%, respectively, compared to untreated cells. Ozone 17-22 interleukin 6 Homo sapiens 52-56 28124586-8 2017 RESULTS: High glucose (30.5 mM) increased mRNA expression of interleukin (IL)-6 and secretion of both IL-6 and IL-8 by astrocytes. Glucose 14-21 interleukin 6 Homo sapiens 61-79 28124586-8 2017 RESULTS: High glucose (30.5 mM) increased mRNA expression of interleukin (IL)-6 and secretion of both IL-6 and IL-8 by astrocytes. Glucose 14-21 interleukin 6 Homo sapiens 102-106 28251164-7 2017 TNF-alpha and IL-6 could aggregate peripheral neuropathy in impaired glucose regulation patients; TNF-alpha might be independent risk factor for peripheral neuropathy in glucose regulation impaired patients. Glucose 69-76 interleukin 6 Homo sapiens 14-18 29617099-2 2017 Doxorubicin (DOX) has failed for multiple reasons, including development of multi-drug resistance, induction of inflammation (IL-6 secretion) and long-term toxicities. Doxorubicin 0-11 interleukin 6 Homo sapiens 126-130 29617099-7 2017 Further studies in MDA-MB-231 cells demonstrated that CARF also inhibited pro-inflammatory IL-6 secretion and NF kappaB transcriptional activity while DOX stimulated both IL-6 and NF kappa-B activity. Doxorubicin 151-154 interleukin 6 Homo sapiens 171-175 29617099-9 2017 Furthermore, exogenous administration of IL-6 potentiated NF Kappa B transcriptional activity, pSTAT3 (Tyr705) and JAK inflammatory signaling as well as cell proliferation in CARF- or DOX-treated MDA-MB-231 cells. carfilzomib 175-179 interleukin 6 Homo sapiens 41-45 29617099-9 2017 Furthermore, exogenous administration of IL-6 potentiated NF Kappa B transcriptional activity, pSTAT3 (Tyr705) and JAK inflammatory signaling as well as cell proliferation in CARF- or DOX-treated MDA-MB-231 cells. Doxorubicin 184-187 interleukin 6 Homo sapiens 41-45 29276908-0 2017 [Correlations of IL-18 and IL-6 with sodium consumption in patients with arterial hypertension and diabetes mellitus]. Sodium 37-43 interleukin 6 Homo sapiens 27-31 29276908-1 2017 AIM: To determine correlations of AH-associated interleukins (IL-18, IL-6) with sodium consumption in AH patients with and without DM. Sodium 80-86 interleukin 6 Homo sapiens 69-73 28286378-6 2017 Iron significantly reduced mRNA levels of IL-6, IL-1beta, TNF-alpha, and iNOS produced by IFN-gamma-polarized M1 macrophages. Iron 0-4 interleukin 6 Homo sapiens 42-46 29332095-1 2017 BACKGROUND/AIMS: Serum levels of brain-derived neurotrophic factor (BDNF) and interleukin-6 (IL-6) were prospectively monitored in relation with therapeutic response to lamotrigine augmentation therapy in 46 (15 males and 31 females) inpatients with treatment-resistant depressive disorder during an 8-week treatment with lamotrigine using an open-study design. Lamotrigine 169-180 interleukin 6 Homo sapiens 93-97 28066435-0 2016 IL-6 Improves the Nitric Oxide-Induced Cytotoxic CD8+ T Cell Dysfunction in Human Chagas Disease. Nitric Oxide 18-30 interleukin 6 Homo sapiens 0-4 28098099-4 2017 This study was designed to evaluate the relationship between IL-6 and IL-10 and serum bicarbonate and metabolic acidosis in HD patients. Bicarbonates 86-97 interleukin 6 Homo sapiens 61-65 28098099-14 2017 Based on the results, metabolic acidosis and bicarbonate could be considered prognostic factors to differentiate the increased levels of IL-6 and IL-10 and associated morbidity and mortality. Bicarbonates 45-56 interleukin 6 Homo sapiens 137-141 28033321-10 2016 DISCUSSION: According to the results it seems that Atorvastatin, Losartan and Captopril have reduced inflammation in in vivo conditions via downregulation of IL-6 and upregulation of TGF-beta. Atorvastatin 51-63 interleukin 6 Homo sapiens 158-162 27229482-6 2016 IL-6 (p&lt;0.001), IL-8 (p = 0.015) and neopterin levels (p = 0.002) were higher in presurgical samples and returned to normal following surgery. Adenosine Monophosphate 8-11 interleukin 6 Homo sapiens 0-4 27773804-5 2016 Pretreatment with aliskiren attenuated the inhibitory effects of IL-6 on eNOS phosphorylation and nitric oxide production. Nitric Oxide 98-110 interleukin 6 Homo sapiens 65-69 27773804-10 2016 In conclusion, aliskiren attenuates the inhibitory effects of IL-6 on eNOS phosphorylation and nitric oxide production and IL-6 induced caveolin-1 phosphorylation. Nitric Oxide 95-107 interleukin 6 Homo sapiens 62-66 28033321-0 2016 Atorvastatin, Losartan and Captopril Lead to Upregulation of TGF-beta, and Downregulation of IL-6 in Coronary Artery Disease and Hypertension. Atorvastatin 0-12 interleukin 6 Homo sapiens 93-97 28066435-8 2016 Furthermore, the treatment of these cultures with an IL-6 neutralizing antibody increased the percentage of T. cruzi-induced CD8+ T cell nitration and raised the release of nitric oxide. Nitric Oxide 173-185 interleukin 6 Homo sapiens 53-57 28078047-5 2016 Synthesis of IL-6, MCP-1 and hyaluronan in unstimulated and stimulated with interleukin-1 (100 pg/ml) HPMC was inhibited in the presence of DHMEQ and the effect was proportional to the dose of the drug. hydroxypropylmethylcellulose-lactose matrix 102-106 interleukin 6 Homo sapiens 13-17 28078047-6 2016 DHMEQ (10 microg/ml) reduced in unstimulated HPMC synthesis of IL-6 (-55%), MCP-1 (-58%) and hyaluronan (-41%). hydroxypropylmethylcellulose-lactose matrix 45-49 interleukin 6 Homo sapiens 63-67 27539101-5 2016 Many significant associations were found between the increase of IL-6, resp. SAA and the amounts of n-6 polyunsaturated fatty acids (namely linoleic, dihomo-gamma-linolenic, docosatetraenoic and docosapentaenoic acid), resp. saturated fatty acids (pentadecanoic, stearic, nonadecanoic) in erythrocyte membranes. n-6 polyunsaturated fatty acids 100-131 interleukin 6 Homo sapiens 65-69 27983705-6 2016 Our results indicated an efficient reduction in pro-inflammatory factors (TNFalpha, IL-6, MCP-1, HMGB1) upon culture with riboflavin supplementation (500-1000 nM), accompanied by elevation in anti-inflammatory adiponectin and IL-10. Riboflavin 122-132 interleukin 6 Homo sapiens 84-88 27964715-13 2016 In the same way, PA reduced IL6, IFN-gamma, TNF-alpha and IL17A production in both concentration and IL2 only at 50 muM (in the presence of ConA). palmitoleic acid 17-19 interleukin 6 Homo sapiens 28-31 27539101-5 2016 Many significant associations were found between the increase of IL-6, resp. SAA and the amounts of n-6 polyunsaturated fatty acids (namely linoleic, dihomo-gamma-linolenic, docosatetraenoic and docosapentaenoic acid), resp. saturated fatty acids (pentadecanoic, stearic, nonadecanoic) in erythrocyte membranes. Linoleic Acid 140-148 interleukin 6 Homo sapiens 65-69 27539101-5 2016 Many significant associations were found between the increase of IL-6, resp. SAA and the amounts of n-6 polyunsaturated fatty acids (namely linoleic, dihomo-gamma-linolenic, docosatetraenoic and docosapentaenoic acid), resp. saturated fatty acids (pentadecanoic, stearic, nonadecanoic) in erythrocyte membranes. Fatty Acids 110-131 interleukin 6 Homo sapiens 65-69 27591823-1 2016 The purpose of this study was to identify if circulating interleukin (IL)-6 and gamma-tocopherol (gammaT) fluctuate with vitamin D status in subjects with an underlying knee joint injury or disease. Vitamin D 121-130 interleukin 6 Homo sapiens 57-75 27816692-0 2016 IL-6, a central acute-phase mediator, as an early biomarker for exposure to zinc-based metal fumes. Metals 87-92 interleukin 6 Homo sapiens 0-4 27816692-11 2016 The median increases of CRP and IL-6 were most pronounced for the welding fume which contained besides zinc also copper (AluBronze). Copper 113-119 interleukin 6 Homo sapiens 32-36 27816692-15 2016 IL-6 may represent a highly sensitive and early biomarker for the exposure to metal fumes containing zinc and copper. Metals 78-83 interleukin 6 Homo sapiens 0-4 27816692-15 2016 IL-6 may represent a highly sensitive and early biomarker for the exposure to metal fumes containing zinc and copper. Copper 110-116 interleukin 6 Homo sapiens 0-4 27931833-4 2016 In addition, poorly regulated glucose metabolism in diabetic patients is often found with increased levels of chronic inflammatory markers, e.g., interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha, and emerging evidence has highlighted activation of the immune response in the progression and development of cancer cells. Glucose 30-37 interleukin 6 Homo sapiens 170-174 27639126-10 2016 ROS scavenger N-acetylcysteine (NAC) and NF-kappaB inhibitor PDTC showed similar effect on PA-induced secretion of TNF-alpha, IL-6, and expression of ICAM-1. Acetylcysteine 14-30 interleukin 6 Homo sapiens 126-130 27639126-10 2016 ROS scavenger N-acetylcysteine (NAC) and NF-kappaB inhibitor PDTC showed similar effect on PA-induced secretion of TNF-alpha, IL-6, and expression of ICAM-1. Acetylcysteine 32-35 interleukin 6 Homo sapiens 126-130 27930715-12 2016 Basal cortisol level was positively correlated with serum IL-6 level in all patients before glucocorticoid therapy. Hydrocortisone 6-14 interleukin 6 Homo sapiens 58-62 27841026-6 2016 Women with Hi-WC had higher IL-6 at rest and delayed increases in IL-6 after a high-carbohydrate meal in all conditions. Carbohydrates 84-96 interleukin 6 Homo sapiens 66-70 27705752-4 2016 Four extracellular factors are necessary for the acquisition of SON expression and lineage plasticity in ePS cells: adenosine (which is produced by the 5" ecto-nucleotidase CD73 and activates in turn the PKA-dependent IL6/STAT3 pathway through the adenosine receptor ADORA2b), IL6, FGF2 and ACTIVIN A. Adenosine 116-125 interleukin 6 Homo sapiens 218-221 27705752-4 2016 Four extracellular factors are necessary for the acquisition of SON expression and lineage plasticity in ePS cells: adenosine (which is produced by the 5" ecto-nucleotidase CD73 and activates in turn the PKA-dependent IL6/STAT3 pathway through the adenosine receptor ADORA2b), IL6, FGF2 and ACTIVIN A. Adenosine 116-125 interleukin 6 Homo sapiens 277-280 27639126-10 2016 ROS scavenger N-acetylcysteine (NAC) and NF-kappaB inhibitor PDTC showed similar effect on PA-induced secretion of TNF-alpha, IL-6, and expression of ICAM-1. Reactive Oxygen Species 0-3 interleukin 6 Homo sapiens 126-130 27861797-4 2016 Interestingly, AS-IL6 does not change IL6 mRNA stability, but induces the enrichment of histone H3 acetylated at lysine 27 (H3K27Ac) at the IL6 promoter. Lysine 113-119 interleukin 6 Homo sapiens 18-21 27566315-0 2016 Relationships between oxycodone pharmacokinetics, central symptoms, and serum interleukin-6 in cachectic cancer patients. Oxycodone 22-31 interleukin 6 Homo sapiens 78-91 27566315-9 2016 The serum IL-6 level was correlated with the plasma concentration of oxycodone and inversely with the metabolic ratio to noroxycodone. Oxycodone 69-78 interleukin 6 Homo sapiens 10-14 27444747-9 2016 Triglycerides correlated weakly with sex-hormone binding globulin (P = 0.0115), and strongly with abdominal visceral fat (P < 0.0001), and interleukin-6 (P = 0.0016) all positively (P = 1.6 x 10-12, 38.9 % of variance). Triglycerides 0-13 interleukin 6 Homo sapiens 142-155 27444747-12 2016 Age was a stronger correlate of low-density lipoprotein cholesterol; interleukin-6 of triglycerides and high-density lipoprotein; and both sex-hormone binding globulin and total abdominal fat of non high-density lipoprotein cholesterol in premenopausal than postmenopausal women. Triglycerides 86-99 interleukin 6 Homo sapiens 69-82 27729238-6 2016 Multiple logistic regression showed that advanced age (over 80years), obesity, actual/former smoking, decreased HDL-cholesterol, chronic kidney disease (CKD) and depression were associated with occurrence of increased level of IL-6 (>2.4pg/ml). Cholesterol 116-127 interleukin 6 Homo sapiens 227-231 28318158-8 2016 2) Compared with H2O2 group, CGRP+H2O2 group significantly increased the SOD activity (P<0.01), ROS content significantly decreased (P<0.01), TNF-alpha, IL-1beta, and IL-6 secretion significantly decreased (P<0.05). Hydrogen Peroxide 34-38 interleukin 6 Homo sapiens 173-177 27443878-10 2016 Intraperitoneal administration of dexamethasone completely abrogated IL-33-mediated peritoneal neutrophil recruitment and prevented plasma IL-6 elevation. Dexamethasone 34-47 interleukin 6 Homo sapiens 139-143 27138049-3 2016 The assay employed a model of the human monocyte cell line U937 stimulated with lipopolysaccharide (LPS) and phorbol 12-myristate 13-acetate (PMA) for the release of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6. Tetradecanoylphorbol Acetate 109-140 interleukin 6 Homo sapiens 204-222 28066685-6 2016 Linoleic acid also significantly increased IL-6 by 2.9-fold and IL-8 by 5.7-fold. Linoleic Acid 0-13 interleukin 6 Homo sapiens 43-47 27748636-8 2016 However twelve genes were were differently regulated by the two compounds: interleukins (IL) IL-1B, IL-6 and a chemokine CCL22 were upregulated by HIX and significantly supressed by Leflunomide. hix 147-150 interleukin 6 Homo sapiens 100-104 27994517-6 2016 In addition, COX-2/PGE2 induces IL-6 release in macrophages. Dinoprostone 19-23 interleukin 6 Homo sapiens 32-36 27957415-0 2016 The role of local IL6/JAK2/STAT3 signaling in high glucose-induced podocyte hypertrophy. Glucose 51-58 interleukin 6 Homo sapiens 18-21 27957415-2 2016 We tested the hypothesis that IL6 and its downstream gp130/JAK2/STAT3 pathway participated in high glucose (HG)-induced podocyte hypertrophy. Glucose 99-106 interleukin 6 Homo sapiens 30-33 27871466-6 2016 Furthermore, when cells were pretreated with rapamycin, autophagy was activated and expression of inflammatory factors (tumor necrosis factor-alpha and interleukin-6) induced by oxLDL was downregulated. Sirolimus 45-54 interleukin 6 Homo sapiens 152-165 27751756-8 2016 Additionally, we observed significantly higher IL-6 concentrations in association with an interquartile range increase in BPA (8.95% increase). bisphenol A 122-125 interleukin 6 Homo sapiens 47-51 27965661-10 2016 LPS/aluminum hydroxide-induced release of IL-1beta and IL-6 was not inhibited by anti-TNFalpha treatment. Aluminum Hydroxide 4-22 interleukin 6 Homo sapiens 55-59 27632703-4 2016 In the present study, we demonstrated that a water-soluble bis-malonic acid fullerene derivative (C60-dicyclopropane-1,1,1",1"-tetracarboxylic acid) markedly diminished the IL-33-induced expression of IL-6 in bone marrow-derived mast cells (BMMC). Water 45-50 interleukin 6 Homo sapiens 201-205 27835955-8 2016 The higher the decrease of IL-6 the higher was the peak oxygen consumption of IPAH patients. Oxygen 56-62 interleukin 6 Homo sapiens 27-31 27831553-9 2016 Furthermore, NF-kappaB inhibitors, JSH-23 and curcumin reduced IL-6 secretion from RS-like cells. Curcumin 46-54 interleukin 6 Homo sapiens 63-67 27824145-6 2016 For the molecular mechanisms, CDDP alone increased the cancer stem cell (CSC)-like properties in gastric cancer cells via activating the interleukin-6 (IL-6)/IL-6 receptor (IL-6R)/signal transducer and activator of transcription 3 (STAT3) signaling. Cisplatin 30-34 interleukin 6 Homo sapiens 137-150 27824145-6 2016 For the molecular mechanisms, CDDP alone increased the cancer stem cell (CSC)-like properties in gastric cancer cells via activating the interleukin-6 (IL-6)/IL-6 receptor (IL-6R)/signal transducer and activator of transcription 3 (STAT3) signaling. Cisplatin 30-34 interleukin 6 Homo sapiens 152-156 27824145-6 2016 For the molecular mechanisms, CDDP alone increased the cancer stem cell (CSC)-like properties in gastric cancer cells via activating the interleukin-6 (IL-6)/IL-6 receptor (IL-6R)/signal transducer and activator of transcription 3 (STAT3) signaling. Cisplatin 30-34 interleukin 6 Homo sapiens 158-162 27884156-18 2016 Myocardial MYLK and IL-6 expression are positively correlated with ejection fraction (EF) response to LVAD placement. lvad 102-106 interleukin 6 Homo sapiens 20-24 27904436-3 2016 In the present study, we determined the effects of metformin on the levels of pro-inflammatory cytokines (i.e., IL-6, TNF-alpha, and MCP-1) and anti-inflammatory mediator IL-10 in blood and urine of patients with type 2 diabetes. Metformin 51-60 interleukin 6 Homo sapiens 112-116 27904436-6 2016 RESULTS: We found that metformin reduced the levels of IL-6 in blood and MCP-1 in urine, but increased IL-10 levels in blood of patients with type 2 diabetes. Metformin 23-32 interleukin 6 Homo sapiens 55-59 27904436-8 2016 Furthermore, compared to individual drug treatment, metformin significantly reduced the levels of serum IL-6 and TNF-alpha, as well as urine MCP-1. Metformin 52-61 interleukin 6 Homo sapiens 104-108 27904683-9 2016 Rapamycin significantly suppressed secretion of IL-6 by tumor cells (P<0.05). Sirolimus 0-9 interleukin 6 Homo sapiens 48-52 27904683-11 2016 Rapamycin effectively reverted the stimulatory effect of IL-6 secreted by tumor cells on endothelial cell invasiveness. Sirolimus 0-9 interleukin 6 Homo sapiens 57-61 27288715-9 2016 In older adults, relative frequency of total positive interactions, those with close others (i.e. spouse, friends, family), and those with coworkers predicted lower concentrations of IL-6 in fully adjusted models, accounting for age, sex, race, education, BMI, smoking and alcohol. Alcohols 273-280 interleukin 6 Homo sapiens 183-187 27598863-9 2016 Pearson correlation exhibited a relationship between the ABTS assay and the expression of three out of five analyzed genes; IL-1beta, IL-6 and IL-8. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid 57-61 interleukin 6 Homo sapiens 134-138 27256567-11 2016 Alcohol withdrawal partially restored the distribution of monocyte subsets and the frequency of IL-6-producing monocytes and increased the frequency of TNF-producing cells in response to LPS and PGN stimulation to levels compared with those in HC. Alcohols 0-7 interleukin 6 Homo sapiens 96-100 27522390-6 2016 RESULTS: Clinical and experimental parts showed that groups with RIPC combined with atorvastatin pre-treatment showed a synergistic protective effect against I/R injury as evidenced by significant reduction (P<0.001) in the levels of TNF-alpha, cTnI (in patients) and IL-6, CK-MB and CRP (in rabbits) while the level of NO was significantly (P<0.001) increased compared with other groups. Atorvastatin 84-96 interleukin 6 Homo sapiens 271-275 27893677-6 2016 There was significantly positive correlation between serum iron and IL-6 serum level.We concluded that humoral, nonspecific immunity (phagocytic activity and oxidative burst), and the IL-6 are influenced in patients with iron deficiency anemia. Iron 59-63 interleukin 6 Homo sapiens 184-188 27590705-4 2016 Consistent with these observations, CDS concentration-dependently inhibited LPS-induced inducible nitric oxide synthase (iNOS) and cyclooxidase-2 (COX-2) expression at the protein level and also iNOS, COX-2, TNF-alpha, and IL-6, IL-1beta expression at the mRNA level. Cadmium 36-39 interleukin 6 Homo sapiens 223-227 26609631-7 2016 We further show that quercetin, a dietary compound having preventive properties for lung cancer, decreased BPDE-stimulated IL-6 secretion from human lung fibroblasts through inhibition of the NF-kappaB and ERK pathways. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 107-111 interleukin 6 Homo sapiens 123-127 26609631-9 2016 Finally, quercetin blocked IL-6-induced STAT3 activation in HBECs, and IL-6 enhancement of HBEC transformation by BPDE was abolished by quercetin treatment. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 114-118 interleukin 6 Homo sapiens 71-75 27543848-7 2016 Inhibition of TLR2 or TLR4 reduced IL-6 production as well as expression of these other factors, and agents inhibiting ROS, MAPKs, NF-kappaB and JAK reduced IL-6 production. ros 119-122 interleukin 6 Homo sapiens 157-161 27490714-7 2016 RESULTS: Following intramuscular capsaicin injection, pro-inflammatory cytokines [TNFalpha, IL-6, IL-8] significantly increased (percent rise from baseline) in both groups, whereas IL-1beta significantly increased in the PTSD group only. Capsaicin 33-42 interleukin 6 Homo sapiens 92-96 27287090-13 2016 Lysed neutrophils inhibited RV16-induced IL-6 and CXCL8 from monocytes. rv16 28-32 interleukin 6 Homo sapiens 41-45 27287090-14 2016 Neutrophil intracellular components alone effectively inhibited RV16-induced monocyte-derived IL-6 and CXCL8. rv16 64-68 interleukin 6 Homo sapiens 94-98 27287090-15 2016 Neutrophil intracellular components reduced RV16-induced IL-6 and CXCL8 mRNA in monocytes. rv16 44-48 interleukin 6 Homo sapiens 57-61 28352827-0 2016 Hydrogen water reduces NSE, IL-6, and TNF-alpha levels in hypoxic-ischemic encephalopathy. Hydrogen 0-8 interleukin 6 Homo sapiens 28-32 28352827-0 2016 Hydrogen water reduces NSE, IL-6, and TNF-alpha levels in hypoxic-ischemic encephalopathy. Water 9-14 interleukin 6 Homo sapiens 28-32 28352827-10 2016 Hydrogen water lowers serum NSE, IL-6, and TNF-alpha levels in HIE newborns, thereby exerting a protective effect. Hydrogen 0-8 interleukin 6 Homo sapiens 33-37 28352827-10 2016 Hydrogen water lowers serum NSE, IL-6, and TNF-alpha levels in HIE newborns, thereby exerting a protective effect. Water 9-14 interleukin 6 Homo sapiens 33-37 27109105-9 2016 In return, cancer cell-CM stimulated BMFs to produce IL-6, which was inhibited by anti-TGF-beta1 neutralizing antibody. bmfs 37-41 interleukin 6 Homo sapiens 53-57 27716424-7 2016 In BEAS-2B cells, both SE-A and SE-R inhibited the increase in production of the inflammatory cytokines IL-6 and IL-8. Serine 32-36 interleukin 6 Homo sapiens 104-108 27892672-10 2016 Conclusions: It seems thatreducing the level of copper in the diet and dosing with penicillamine leads to decline of angiogenesis-related factorssuch as VEGF, IL-6 and TNF-alpha. Copper 48-54 interleukin 6 Homo sapiens 159-163 26609631-4 2016 Here, we show that benzo[a]pyrene diol epoxide (BPDE, the active metabolite of cigarette smoke carcinogen benzo[a]pyrene)-induced human bronchial epithelial cell (HBEC) transformation was enhanced by IL-6 in vitro. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 19-46 interleukin 6 Homo sapiens 200-204 26609631-4 2016 Here, we show that benzo[a]pyrene diol epoxide (BPDE, the active metabolite of cigarette smoke carcinogen benzo[a]pyrene)-induced human bronchial epithelial cell (HBEC) transformation was enhanced by IL-6 in vitro. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 48-52 interleukin 6 Homo sapiens 200-204 26609631-5 2016 The carcinogen/IL-6-transformed cells exhibited higher expression of STAT3 (signal transducer and activator of transcription 3) when compared with cells transformed by BPDE alone. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 168-172 interleukin 6 Homo sapiens 15-19 28123888-4 2016 On the contrary, longer OS was associated to low levels of the proinflammatory proteins IL-6 and CRP and tumor-associated factors S100B and LDH both at baseline and after treatment. Osmium 24-26 interleukin 6 Homo sapiens 88-135 28929697-12 2016 This study showed that berberine in addition to the general therapy can significantly lower the levels of serum MIF and IL-6, reduce the degree of carotid atherosclerosis to some extent and improve neurological impairment and the prognosis of patients with AIS. Berberine 23-32 interleukin 6 Homo sapiens 120-124 27739445-6 2016 Using ex vivo human CRC explants, quininib significantly reduced the secretions of IL-6, IL-8, VEGF, ENA-78, GRO-alpha, TNF, IL-1beta and MCP-1 ex vivo (all values p < 0.01). quininib 34-42 interleukin 6 Homo sapiens 83-87 27534429-6 2016 Moreover, surfactin also induced DCs to release IL-6 and TNF-alpha, indicating that DCs were functionally mature. surfactin peptide 10-19 interleukin 6 Homo sapiens 48-52 27590705-3 2016 In addition, CDS was found to concentration-dependently reduce the production of NO, PGE2, and the pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1beta (IL-1beta) induced by LPS in macrophages. Cadmium 13-16 interleukin 6 Homo sapiens 176-189 27590705-3 2016 In addition, CDS was found to concentration-dependently reduce the production of NO, PGE2, and the pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1beta (IL-1beta) induced by LPS in macrophages. Cadmium 13-16 interleukin 6 Homo sapiens 191-195 26790758-6 2016 Greater changes in IL-6 from baseline to 3h after LPS administration significantly and independently predicted a more pronounced LPS-induced state anxiety response. Tritium 41-43 interleukin 6 Homo sapiens 19-23 27590705-6 2016 Taken together, these results suggest that the anti-inflammatory effect of CDS is associated with the downregulation of iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 expression via the negative regulation of NF-kappaB and AP-1 activation in LPS-induced RAW 264.7 macrophages. Cadmium 75-78 interleukin 6 Homo sapiens 158-162 26825339-9 2016 IL-6 mRNA expression and protein secretion was significantly repressed by dexamethasone acting in a temporally distinct manner to increase MKP-1, deactivate p38 MAPK, and modulate TTP phosphorylation status. Dexamethasone 74-87 interleukin 6 Homo sapiens 0-4 27502766-6 2016 Immunoblot analyses demonstrated that Oncostatin M (OSM), a member of the interleukin-6 (IL-6) cytokine family, induced both P-STAT3 Tyr and P-STAT3 Ser in SH-SY5Y cells. Tyrosine 133-136 interleukin 6 Homo sapiens 89-93 27207502-5 2016 The aim of the study was to determine whether vitamin D could affect IL-13 and IL-6 levels, and regulate the activity of tight-junction proteins. Vitamin D 46-55 interleukin 6 Homo sapiens 79-83 27193105-0 2016 Association between IL-6 Gene (-174 & -572 G/C) Polymorphisms and Endometrial Adenocarcinoma Risk. Adenosine Monophosphate 37-40 interleukin 6 Homo sapiens 20-24 27181082-5 2016 Results showed that in conditioned media obtained from late EPC cultures, the levels of interleukin-6, isoprostanes and nitric oxide bioavailability were increased and reduced respectively after 3h of doxorubicin treatment. Tritium 195-197 interleukin 6 Homo sapiens 88-101 27181082-5 2016 Results showed that in conditioned media obtained from late EPC cultures, the levels of interleukin-6, isoprostanes and nitric oxide bioavailability were increased and reduced respectively after 3h of doxorubicin treatment. Doxorubicin 201-212 interleukin 6 Homo sapiens 88-101 27599556-7 2016 Heparin also decreased the TNF-alpha-induced mRNA and protein expression levels of IL-6, IL-8, TNF-alpha and cyclin D1 in a dose-dependent manner. Heparin 0-7 interleukin 6 Homo sapiens 83-87 29441928-10 2016 Overexpression and knockdown of MALAT1 respectively augmented and abolished IL6-induced expression of NOX2, NOX activity/cellular ROS production, and activation of the human NOX2 gene promoter, whereas MALAT1 alone in the absence of IL-6 treatment showed no significant effect. Reactive Oxygen Species 130-133 interleukin 6 Homo sapiens 76-79 27427241-7 2016 The most potent metals, Cd(2+), Zn(2+) and As(3+) induced highest levels of oxidative activity, and ROS appeared to be central in their CXCL8 and IL-6 responses. Cadmium 24-26 interleukin 6 Homo sapiens 146-150 27427241-7 2016 The most potent metals, Cd(2+), Zn(2+) and As(3+) induced highest levels of oxidative activity, and ROS appeared to be central in their CXCL8 and IL-6 responses. Zinc 32-34 interleukin 6 Homo sapiens 146-150 27427241-4 2016 Exposure to Cd(2+), Zn(2+) and As(3+) induced CXCL8 and IL-6 release at concentrations below 100muM, and Mn(2+) and Ni(2+) at concentrations above 200muM. Cadmium 12-14 interleukin 6 Homo sapiens 56-60 27427241-4 2016 Exposure to Cd(2+), Zn(2+) and As(3+) induced CXCL8 and IL-6 release at concentrations below 100muM, and Mn(2+) and Ni(2+) at concentrations above 200muM. Zinc 20-22 interleukin 6 Homo sapiens 56-60 27427241-7 2016 The most potent metals, Cd(2+), Zn(2+) and As(3+) induced highest levels of oxidative activity, and ROS appeared to be central in their CXCL8 and IL-6 responses. ros 100-103 interleukin 6 Homo sapiens 146-150 27427241-9 2016 However, the NF-kappaB pathway appeared predominately to be involved only in Zn(2+)- and As(3+)-induced CXCL8 and IL-6 responses. Zinc 77-79 interleukin 6 Homo sapiens 114-118 27746733-10 2016 Atorvastatin therapy was associated with increases in interleukin-6 within the normal range and a tendency toward reduction in blood urea. Atorvastatin 0-12 interleukin 6 Homo sapiens 54-67 27725801-9 2016 The treatment with atorvastatin was associated with a decrease in C-reactive protein and interleukin-6 by 23.1 and 49.2%, respectively, compared with baseline values. Atorvastatin 19-31 interleukin 6 Homo sapiens 89-102 27681882-11 2016 RESULTS: Nicotine treatment dose dependently limits the production of critical proinflammatory cytokines such as IL-6 (60.5 +- 3.3, %inhibition), IL-1beta (42.4 +- 1.7, %inhibition), and TNF-alpha (68.9 +- 7.7, %inhibition) by activated human astrocytes. Nicotine 9-17 interleukin 6 Homo sapiens 113-117 27681882-14 2016 Importantly, nicotine"s inhibitory effect on IL-6 production was reversed with the specific COX-2 inhibitor NS-398. Nicotine 13-21 interleukin 6 Homo sapiens 45-49 27481191-7 2016 Diketopiperazine suppressed the PolyP-mediated vascular barrier permeability, upregulation of inflammatory biomarkers, adhesion/migration of leukocytes, and activation and/or production of nuclear factor-kappaB, tumor necrosis factor-alpha, and interleukin-6. Polyphosphates 32-37 interleukin 6 Homo sapiens 245-258 27206315-10 2016 Indeed, treatment of OC cell lines with TNFalpha and IL6 induced a selective increase in the expression of TAP1 and multidrug resistance protein 1, whereas TAP1 silencing sensitized cells to cisplatin-induced apoptosis. Cisplatin 191-200 interleukin 6 Homo sapiens 53-56 27650878-11 2016 Atorvastatin and simvastatin suppressed the DC maturation showing lower expression of CD80, CD83, and CD86, and limited their production of tumor necrosis factor-alpha, IL-1beta and IL-6, and increased transforming growth factor-beta and IL-10 secretion. Atorvastatin 0-12 interleukin 6 Homo sapiens 182-186 27641436-5 2016 Metal fume PM2.5 resulted in decreased cell viability and increased levels of 8-hydroxy-2"-deoxyguanosine (8-OHdG), interleukin (IL)-6, and nitric oxide (NO) in human coronary artery epithelial cells (HCAECs). Metals 0-5 interleukin 6 Homo sapiens 116-134 27666890-3 2016 Testosterone 10 mumol/L was added into indirect co-culture for 24 h. ELISA was used to testing IL-6, MCP-1 concentrations in supernatant. Testosterone 0-12 interleukin 6 Homo sapiens 95-99 27666890-6 2016 Results: Testosterone enhanced inflammatory cytokines (IL-6, MCP-1) production in indirect co-culture of 3T3-L1 adipocytes and RAW264.7 macrophages, promoted the activation of ERK1/2 and nuclear factor kappa B p65, and inhibited glucose uptake in adipocytes. Testosterone 9-21 interleukin 6 Homo sapiens 55-59 27598116-5 2016 IL-6 levels in the HMC-1 stimulated by phorbol-12-myristate-13-acetate and A23187 were apparently decreased by the treatment of atractylodin. Tetradecanoylphorbol Acetate 39-70 interleukin 6 Homo sapiens 0-4 26991527-7 2016 Three of the 6 molecules were significantly associated with baseline KOOS4 (those with higher SF IL-6, TIMP-1, or TSG-6 had lower KOOS4 ). koos4 69-74 interleukin 6 Homo sapiens 97-101 27208497-4 2016 As expected, ethanol led to robust increases in IL-6 and IkappaBalpha gene expression in hippocampus, amygdala and bed nucleus of the stria terminalis (BNST), whereas IL-1beta and TNFalpha were suppressed, thereby replicating our prior work. Ethanol 13-20 interleukin 6 Homo sapiens 48-52 27208497-5 2016 Ethanol-dependent increases in IL-6 and IkappaBalpha remained significant in all structures - even after 6 days of ethanol. Ethanol 0-7 interleukin 6 Homo sapiens 31-35 27239967-0 2016 Inhibition effect of cypermethrin mediated by co-regulators SRC-1 and SMRT in interleukin-6-induced androgen receptor activation. cypermethrin 21-33 interleukin 6 Homo sapiens 78-91 27239967-2 2016 The Real-Time Cell Analysis (RTCA) iCELLigence system was used to investigate the inhibitory effect of cypermethrin on interleukin-6 (IL-6)-induced ligand-independent LNCaP cell growth. cypermethrin 103-115 interleukin 6 Homo sapiens 119-132 27611333-8 2016 A mouse model of mastocytosis recapitulated the biphasic changes in DJ-1 and the escalating IL-6, ROS and DJ-1 levels as mast cells accumulate, findings which were reversed with anti-IL-6 receptor blocking antibody. Reactive Oxygen Species 98-101 interleukin 6 Homo sapiens 183-187 26991527-9 2016 Of these, IL-6 alone significantly accounted for the molecular contribution to baseline KOOS4 and change in KOOS4 over 3 months. koos4 88-93 interleukin 6 Homo sapiens 10-14 26991527-9 2016 Of these, IL-6 alone significantly accounted for the molecular contribution to baseline KOOS4 and change in KOOS4 over 3 months. koos4 108-113 interleukin 6 Homo sapiens 10-14 27280944-5 2016 RESULTS: The CP group showed that the overall methylation rates of IL-6 promoter that contained 19 cytosine-guanine dinucleotide (CpG) motifs were significantly decreased in GT in comparison to PB (p<0.001), which was significantly negatively correlated with the probing depth (p=0.003). cytidylyl-3'-5'-guanosine 99-128 interleukin 6 Homo sapiens 67-71 27488030-0 2016 Reactive Oxygen Stimulation of Interleukin-6 Release in the Human Trophoblast Cell Line HTR-8/SVneo by the Trichlorethylene Metabolite S-(1,2-Dichloro)-l-Cysteine. Oxygen 9-15 interleukin 6 Homo sapiens 31-44 27488030-0 2016 Reactive Oxygen Stimulation of Interleukin-6 Release in the Human Trophoblast Cell Line HTR-8/SVneo by the Trichlorethylene Metabolite S-(1,2-Dichloro)-l-Cysteine. s-(1,2-dichloro)-l-cysteine 135-162 interleukin 6 Homo sapiens 31-44 27488030-7 2016 Moreover, 10 and 20 muM DCVC increased mRNA expression and release of interleukin-6 (IL-6) after 24-h exposure, and these responses were inhibited by the cysteine conjugate beta-lyase inhibitor aminooxyacetic acid and by treatments with antioxidants (alpha-tocopherol and deferoxamine), suggesting that DCVC-stimulated IL-6 release in HTR-8/SVneo cells is dependent on beta-lyase metabolic activation and increased generation of ROS. Cysteine 154-162 interleukin 6 Homo sapiens 70-83 27488030-7 2016 Moreover, 10 and 20 muM DCVC increased mRNA expression and release of interleukin-6 (IL-6) after 24-h exposure, and these responses were inhibited by the cysteine conjugate beta-lyase inhibitor aminooxyacetic acid and by treatments with antioxidants (alpha-tocopherol and deferoxamine), suggesting that DCVC-stimulated IL-6 release in HTR-8/SVneo cells is dependent on beta-lyase metabolic activation and increased generation of ROS. Cysteine 154-162 interleukin 6 Homo sapiens 85-89 27488030-7 2016 Moreover, 10 and 20 muM DCVC increased mRNA expression and release of interleukin-6 (IL-6) after 24-h exposure, and these responses were inhibited by the cysteine conjugate beta-lyase inhibitor aminooxyacetic acid and by treatments with antioxidants (alpha-tocopherol and deferoxamine), suggesting that DCVC-stimulated IL-6 release in HTR-8/SVneo cells is dependent on beta-lyase metabolic activation and increased generation of ROS. Cysteine 154-162 interleukin 6 Homo sapiens 319-323 27488030-7 2016 Moreover, 10 and 20 muM DCVC increased mRNA expression and release of interleukin-6 (IL-6) after 24-h exposure, and these responses were inhibited by the cysteine conjugate beta-lyase inhibitor aminooxyacetic acid and by treatments with antioxidants (alpha-tocopherol and deferoxamine), suggesting that DCVC-stimulated IL-6 release in HTR-8/SVneo cells is dependent on beta-lyase metabolic activation and increased generation of ROS. Reactive Oxygen Species 429-432 interleukin 6 Homo sapiens 85-89 27488030-9 2016 The present study demonstrates that DCVC stimulated ROS generation in the human placental cell line HTR-8/SVneo and provides new evidence of mechanistic linkage between DCVC-stimulated ROS and increase in proinflammatory cytokine IL-6. Reactive Oxygen Species 185-188 interleukin 6 Homo sapiens 230-234 27239967-6 2016 The results indicate that the IL-6-mediated AR antagonism induced by cypermethrin is related to repress the recruitment of co-regulators SRC-1 and SMRT to the AR in a ligand-independent manner. cypermethrin 69-81 interleukin 6 Homo sapiens 30-34 27239967-7 2016 Inhibition of the interactions of AR-SRC-1 and AR-SMRT mediated by IL-6 contributes to the AR antagonism induced by cypermethrin. cypermethrin 116-128 interleukin 6 Homo sapiens 67-71 27239967-2 2016 The Real-Time Cell Analysis (RTCA) iCELLigence system was used to investigate the inhibitory effect of cypermethrin on interleukin-6 (IL-6)-induced ligand-independent LNCaP cell growth. cypermethrin 103-115 interleukin 6 Homo sapiens 134-138 27239967-3 2016 Then, the mammalian two-hybrid assays were applied to clarify whether the mechanism of IL-6-induced AR antagonism of cypermethrin was associated with the interactions of the AR and co-activator steroid receptor co-activator-1 (SRC-1) and co-repressor silencing mediator for retinoid and thyroid hormone receptors (SMRT). cypermethrin 117-129 interleukin 6 Homo sapiens 87-91 27239967-4 2016 Cypermethrin inhibited the LNCaP cell growth induced by IL-6. cypermethrin 0-12 interleukin 6 Homo sapiens 56-60 27239967-5 2016 The interactions of AR-SRC-1 and AR-SMRT mediated by IL-6 were suppressed by cypermethrin. cypermethrin 77-89 interleukin 6 Homo sapiens 53-57 26553320-10 2016 Compared with the monoculture, MMP-1, MMP-3, interleukin (IL)-1beta, IL-6, IL-17, and IL-21 in supernatant of cocultures were markedly elevated after treatment with nicotine. Nicotine 165-173 interleukin 6 Homo sapiens 69-73 27353644-4 2016 RESULTS: The urinary IL-6 concentrations increased from uACR <10 (97.2+-26.4pg/ml) to uACR 10-30 (113.6+-28.0pg/ml) and to uACR >30mg/g creatinine (163.5+-25.6pg/ml) (P<0.05 and P<0.001, respectively) patients. Creatinine 142-152 interleukin 6 Homo sapiens 21-25 27379793-1 2016 PURPOSE: This investigation examined if a high carbohydrate (CHO) diet, maintained across a seven-day training period, could attenuate post-exercise interleukin-6 (IL-6) and serum hepcidin levels. Carbohydrates 47-59 interleukin 6 Homo sapiens 149-162 27379793-1 2016 PURPOSE: This investigation examined if a high carbohydrate (CHO) diet, maintained across a seven-day training period, could attenuate post-exercise interleukin-6 (IL-6) and serum hepcidin levels. Carbohydrates 47-59 interleukin 6 Homo sapiens 164-168 27904616-8 2016 IL-6 decreased significantly after folic acid use (P < 0.05). Folic Acid 35-45 interleukin 6 Homo sapiens 0-4 27477309-5 2016 Under these conditions, Pam3CSK4 induces corticosteroid insensitivity; demonstrated by substantially reduced ability of the corticosteroid dexamethasone to repress TNFalpha-induced interleukin 6 secretion. Dexamethasone 139-152 interleukin 6 Homo sapiens 181-194 27388883-8 2016 Treatment with 5-ASA after burn injury prevented the burn-induced increase in permeability, partially restored normal intestinal transit, normalized the levels of the proinflammatory cytokines IL-6 and IL-18, and restored tight junction protein expression of claudin-4 and occludin compared with that of sham levels. Mesalamine 15-20 interleukin 6 Homo sapiens 193-197 27287412-7 2016 Cisplatin treatment increased expression of transforming growth factor-beta in cancer cells, and the conditioned media from cancer cells activated fibroblasts and increased their IL-6 production. Cisplatin 0-9 interleukin 6 Homo sapiens 179-183 27058046-0 2016 Alcohol Intoxication Reduces Systemic Interleukin-6 Levels and Leukocyte Counts After Severe TBI Compared With Not Intoxicated TBI Patients. Alcohols 0-7 interleukin 6 Homo sapiens 38-51 26289409-0 2016 Pharmacogenetic Study on the Impact of Rivastigmine Concerning Genetic Variants of A2M and IL-6 Genes on Iranian Alzheimer"s Patients. Rivastigmine 39-51 interleukin 6 Homo sapiens 91-95 27392742-0 2016 Effect of curcumin on circulating interleukin-6 concentrations: A systematic review and meta-analysis of randomized controlled trials. Curcumin 10-18 interleukin 6 Homo sapiens 34-47 27392742-6 2016 There was a significant association between the IL-6-lowering activity of curcumin and baseline IL-6 concentration (slope: -0.51; 95% CI: -0.80, -0.23; p=0.005). Curcumin 74-82 interleukin 6 Homo sapiens 48-52 27392742-6 2016 There was a significant association between the IL-6-lowering activity of curcumin and baseline IL-6 concentration (slope: -0.51; 95% CI: -0.80, -0.23; p=0.005). Curcumin 74-82 interleukin 6 Homo sapiens 96-100 27392742-7 2016 This meta-analysis of RCTs suggested a significant effect of curcumin in lowering circulating IL-6 concentrations. Curcumin 61-69 interleukin 6 Homo sapiens 94-98 27058046-16 2016 CONCLUSIONS: This study shows that positive BAC in TBI patients is associated with lower systemic IL-6 levels and leukocyte numbers, indicating that positive BAC may have immunosuppressive effects in this cohort of patients compared with TBI patients who were not alcohol intoxicated. Alcohols 264-271 interleukin 6 Homo sapiens 98-102 27377137-6 2016 The plasma IL-6 response to exercise (reported as fold changes) was significantly greater in HIGH (2.70 +- 1.51) than LOW (1.40 +- 0.32) (P = 0.04) and was also positively correlated to the mean exercise oxygen uptake (r = 0.54, P < 0.01). Oxygen 204-210 interleukin 6 Homo sapiens 11-15 27458080-6 2016 Dabrafenib suppressed the PolyP-mediated vascular barrier permeability, upregulation of inflammatory biomarkers, adhesion/migration of leukocytes, and activation and/or production of nuclear factor-kappaB, tumor necrosis factor-alpha, and interleukin-6. Polyphosphates 26-31 interleukin 6 Homo sapiens 239-252 27652031-4 2016 Interleukin-6 (IL-6) released from the exercising muscles may be involved in and could therefore explain acute adaptations on glucose metabolism. Glucose 126-133 interleukin 6 Homo sapiens 0-13 27652031-4 2016 Interleukin-6 (IL-6) released from the exercising muscles may be involved in and could therefore explain acute adaptations on glucose metabolism. Glucose 126-133 interleukin 6 Homo sapiens 15-19 28978005-0 2017 Bazedoxifene enhances the anti-tumor effects of cisplatin and radiation treatment by blocking IL-6 signaling in head and neck cancer. Cisplatin 48-57 interleukin 6 Homo sapiens 94-98 27418629-3 2016 METHODS AND RESULTS: In primary hepatocytes from healthy animals, metformin and the IKKbeta (inhibitor of kappa B kinase) inhibitor BI605906 both inhibited tumor necrosis factor-alpha-dependent IkappaB degradation and expression of proinflammatory mediators interleukin-6, interleukin-1beta, and CXCL1/2 (C-X-C motif ligand 1/2). Metformin 66-75 interleukin 6 Homo sapiens 258-271 27470399-6 2016 Within-group analysis revealed significant reductions in serum concentrations of TNF-alpha, IL-6, TGF-beta and MCP-1 following curcumin supplementation (p<0.001). Curcumin 127-135 interleukin 6 Homo sapiens 92-96 27470399-8 2016 Between-group comparison suggested significantly greater reductions in serum concentrations of TNF-alpha, IL-6, TGF-beta and MCP-1 in the curcumin versus placebo group (p<0.001). Curcumin 138-146 interleukin 6 Homo sapiens 106-110 27027581-9 2016 IL-6 mRNA expressions were down-regulated significantly in HA and HA + 5% GSH groups (both p < 0.05) but up-regulated when HA supplemented with 10% and 20% GSH (both p < 0.01). Glutathione 74-77 interleukin 6 Homo sapiens 0-4 27470424-8 2016 The levels of c-Fos, NF-kappaB, IL-6, and TNF-alpha were upregulated in LPS- and PGN-treated eyes and downregulated by CSA treatment. Cyclosporine 119-122 interleukin 6 Homo sapiens 32-36 27556215-7 2016 Further studies demonstrated that curcumin treatment (20 muM) significantly inhibited proinflammatory factors, including IL-6, ELAM-1, IL-1alpha, and IL-8, whereas it decreased activities of senescence marker SA-beta-gal, and lowered levels of carbonylated proteins and apoptotic cell numbers. Curcumin 34-42 interleukin 6 Homo sapiens 121-125 27272182-10 2016 DHEAS was independently associated with grip strength and IL-6 with grip strength and gait speed trajectories. Dehydroepiandrosterone Sulfate 0-5 interleukin 6 Homo sapiens 58-62 26756719-5 2016 RBL-2H3 were pre-treated with exogenous melatonin (MELx) at physiological (100nM) and pharmacological (1 mM) doses for 30 min, washed and activated with PMACI (phorbol 12-myristate 13-acetate plus calcium ionophore A23187) for 2 h and 12 h. The data shows that pre-treatment of MELx in stimulated mast cells, significantly reduced the levels of endogenous melatonin production (MELn), TNF-alpha and IL-6. Melatonin 40-49 interleukin 6 Homo sapiens 399-403 27027581-9 2016 IL-6 mRNA expressions were down-regulated significantly in HA and HA + 5% GSH groups (both p < 0.05) but up-regulated when HA supplemented with 10% and 20% GSH (both p < 0.01). Glutathione 159-162 interleukin 6 Homo sapiens 0-4 27331408-4 2016 The 9 groups of interconnected pathways were mainly involved with muscle cell proliferation, cellular response to interleukin-6, cell adhesion molecules, and ethanol oxidation, which might participate in the development of EC.Our findings provide genetic evidence and new insight for exploring the molecular mechanisms of EC. Ethanol 158-165 interleukin 6 Homo sapiens 114-127 27240190-4 2016 Our results show that 7-hydroxycoumarin (7-OHC) prevents UVB-induced activation of NF-kappaB thereby subsequently preventing the overexpression of TNF-alpha and IL-6 in HDFa cells. 7-hydroxycoumarin 22-39 interleukin 6 Homo sapiens 161-165 27263035-9 2016 Strong negative correlation was found between IL-6 and L-arginine levels in the hyperacute phase in patients with poststroke infection. Arginine 55-65 interleukin 6 Homo sapiens 46-50 27446449-3 2016 The data showed that atorvastatin decreased the visfatin-induced expression of interleukin (IL)-6 and IL-8 in HCAECs. Atorvastatin 21-33 interleukin 6 Homo sapiens 79-97 27271044-5 2016 G1 inhibited the secretion of two proinflammatory cytokines, interleukin (IL)-6 and IL-8, in cells stimulated by adenosine 5"-(gamma-thio)triphosphate (ATPgammaS). adenosine 5'-O-(3-thiotriphosphate) 113-150 interleukin 6 Homo sapiens 61-79 27271044-5 2016 G1 inhibited the secretion of two proinflammatory cytokines, interleukin (IL)-6 and IL-8, in cells stimulated by adenosine 5"-(gamma-thio)triphosphate (ATPgammaS). adenosine 5'-O-(3-thiotriphosphate) 152-161 interleukin 6 Homo sapiens 61-79 27181326-13 2016 This sensitization is likely initiated by cyclo-oxygenase-2 dependent synthesis of prostaglandin E2, which is stimulated by elevated levels of IL-1beta or IL-6. Dinoprostone 83-99 interleukin 6 Homo sapiens 155-159 27196743-9 2016 The results showed that the HMGB1A/heparin complex reduced pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and IL-1beta, more effectively than HMGB1A or heparin alone. Heparin 35-42 interleukin 6 Homo sapiens 138-151 27196743-9 2016 The results showed that the HMGB1A/heparin complex reduced pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and IL-1beta, more effectively than HMGB1A or heparin alone. Heparin 35-42 interleukin 6 Homo sapiens 153-157 27062045-5 2016 Here, we found that the melatonin treatment markedly inhibited the senescent characteristics of CPCs after exposed to sublethal concentration of H2 O2 , including the increase in senescence-associated beta-galactosidase (SA-beta-gal)-positive CPCs, senescence-associated heterochromatin loci (SAHF), secretory IL-6 level, and the upregulation of p53 and p21 proteins. Melatonin 24-33 interleukin 6 Homo sapiens 310-314 27478543-7 2016 Increased mRNA levels of tumor necrosis factor-alpha and interleukin (IL)-6 induced by LPS were significantly attenuated, and decreased levels of IL-10 and brain-derived neurotrophic factor were significantly restored by resveratrol and miR-Let7A overexpression, respectively, or in combination. Resveratrol 221-232 interleukin 6 Homo sapiens 57-75 28149310-5 2016 RESULTS: Compared with the placebo, CoQ10 intake led to a significant reduction in serum interleukin 6 (IL-6) (-1.7 +- 1.6 vs. 0.8 +- 1.7 ng/l, P < 0.001) and protein carbonyl (PCO) levels (-0.2 +- 0.3 vs. 0.1 +- 0.2 nmol/mg protein, P < 0.001). coenzyme Q10 36-41 interleukin 6 Homo sapiens 89-102 27198191-9 2016 Alcohol also altered peripheral clock gene amplitude of peripheral blood mononuclear cells in CLOCK, BMAL, PER1, CRY1, and CRY2 in both groups, and inflammatory markers lipopolysaccharide-binding protein, LPS, and IL-6 had an elevated mesor at baseline in NW vs. DW and became arrhythmic with alcohol consumption. Alcohols 0-7 interleukin 6 Homo sapiens 214-218 28149310-5 2016 RESULTS: Compared with the placebo, CoQ10 intake led to a significant reduction in serum interleukin 6 (IL-6) (-1.7 +- 1.6 vs. 0.8 +- 1.7 ng/l, P < 0.001) and protein carbonyl (PCO) levels (-0.2 +- 0.3 vs. 0.1 +- 0.2 nmol/mg protein, P < 0.001). coenzyme Q10 36-41 interleukin 6 Homo sapiens 104-108 26305116-9 2016 Metformin can exert an anti-inflammatory effect by direct inhibition of IL-6, TNF-alpha, and VEGF. Metformin 0-9 interleukin 6 Homo sapiens 72-76 27216197-8 2016 Unexpectedly, IL6-type cytokine signaling inducing STAT3 activation rendered cervical cancer cells significantly more susceptible to chemotherapeutic drugs, that is, cisplatin or etoposide. Cisplatin 166-175 interleukin 6 Homo sapiens 14-17 27185063-4 2016 Exposure of HCAECs to ZnONPs resulted in decreased cell viability and increased levels of 8-OHdG, IL-6, and NO. znonps 22-28 interleukin 6 Homo sapiens 98-102 25976168-5 2016 We also found that the inflammatory cytokines IL-1, IL-6, and TNF-alpha were induced more strongly by titanium particles (TiMPs) group than by either MgMPs or control. Titanium 102-110 interleukin 6 Homo sapiens 52-56 27075863-1 2016 BACKGROUND: This randomized controlled trial aimed to evaluate the effects of seven-day preoperative treatment with two different dosages of atorvastatin on the incidence of postoperative atrial fibrillation (POAF) and release of inflammatory markers such as high-sensitive C-reactive protein (hsCRP) and interleukin-6 in patients undergoing elective first-time on-pump coronary artery bypass grafting (CABG). Atorvastatin 141-153 interleukin 6 Homo sapiens 305-318 27011369-6 2016 Unfractionated heparin as well as tinzaparin attenuated the IL-1beta-mediated induction of IL-6, IL-11, and LIF on protein and messenger RNA (mRNA) levels. Heparin 15-22 interleukin 6 Homo sapiens 91-95 27011369-8 2016 CONCLUSIONS: Unfractionated heparin and the low molecular weight heparin tinzaparin have modulating effects on IL-1beta-induced endometrial cytokines of the IL-6 family during decidualization. Heparin 28-35 interleukin 6 Homo sapiens 157-161 27011369-8 2016 CONCLUSIONS: Unfractionated heparin and the low molecular weight heparin tinzaparin have modulating effects on IL-1beta-induced endometrial cytokines of the IL-6 family during decidualization. Heparin 65-72 interleukin 6 Homo sapiens 157-161 27034404-4 2016 In vitro, we showed that fungal killing by IL-6/23-stimulated human peripheral blood neutrophils was impaired by JAK/STAT inhibitors Ruxolitinib and Stattic, and by the retinoic acid receptor-related orphan receptor gammat inhibitor SR1001. SR1001 233-239 interleukin 6 Homo sapiens 43-47 27262206-5 2016 In our IL-6 treated FAE model, the nanoparticle transport almost disappeared at 4 C or after the addition of 5-(N-ethyl-N-isopropyl) amiloride, an inhibitor of macropinocytosis. ethylisopropylamiloride 109-142 interleukin 6 Homo sapiens 7-11 27348013-17 2016 Resolution of increased reactive oxygen species requires increased expression of genes responsible for dismutation of increased ROS which is partially achieved by IL-6 mediated activation of signal transducers and activators of transcription 3 (STAT3). Reactive Oxygen Species 24-47 interleukin 6 Homo sapiens 163-167 27181360-0 2016 Iron participated in breast cancer chemoresistance by reinforcing IL-6 paracrine loop. Iron 0-4 interleukin 6 Homo sapiens 66-70 27181360-2 2016 IL-6 produced by TAMs and downstream IL-6/STAT3 signaling pathway is central regulator in chemotherapeutic response. Tamoxifen 17-21 interleukin 6 Homo sapiens 0-4 27181360-7 2016 Furthermore, Iron reinforced the IL-6 paracrine loop between TAMs and tumor cells resulting in enhanced chemo-resistance. Iron 13-17 interleukin 6 Homo sapiens 33-37 27181360-8 2016 Targeting iron metabolism could disturb the reciprocal interaction between tumor cells and TAMs, breaking the local IL-6 rich niche and blocking IL-6 signaling pathway, which could be promising strategy to overcome chemo-resistance. Iron 10-14 interleukin 6 Homo sapiens 116-120 27181360-8 2016 Targeting iron metabolism could disturb the reciprocal interaction between tumor cells and TAMs, breaking the local IL-6 rich niche and blocking IL-6 signaling pathway, which could be promising strategy to overcome chemo-resistance. Iron 10-14 interleukin 6 Homo sapiens 145-149 27020921-10 2016 However, in the OE group, IL-6 and IL-10 levels 2 weeks after the surgery were still significantly higher than those before the surgery (all P < 0.05); IFN-gamma levels in both groups recovered to the pre-operative levels, with higher level in the MIE group than that in the OE group (P < 0.05). oe 16-18 interleukin 6 Homo sapiens 26-30 27348013-17 2016 Resolution of increased reactive oxygen species requires increased expression of genes responsible for dismutation of increased ROS which is partially achieved by IL-6 mediated activation of signal transducers and activators of transcription 3 (STAT3). Reactive Oxygen Species 128-131 interleukin 6 Homo sapiens 163-167 27167341-10 2016 Taken together, SDF-1alpha and IL-6 secreted from PSC induced PDAC cell proliferation via Nrf2-activated metabolic reprogramming and ROS detoxification. ros 133-136 interleukin 6 Homo sapiens 31-35 27045865-14 2016 CONCLUSIONS: Berberine, baicalin and geniposide could neutralize LPS by binding with lipid A and then reduce the release of IL-6 and TNF-alpha induced by LPS. Berberine 13-22 interleukin 6 Homo sapiens 124-128 27045865-14 2016 CONCLUSIONS: Berberine, baicalin and geniposide could neutralize LPS by binding with lipid A and then reduce the release of IL-6 and TNF-alpha induced by LPS. geniposide 37-47 interleukin 6 Homo sapiens 124-128 27308826-10 2016 Interestingly, there was a mean increase in all inflammatory cytokines (IL-1beta, IL-6, and IL-8) during the saline treatment from day 1 to week 3, whereas during the Tyloxapol treatment, all cytokines decreased. Sodium Chloride 109-115 interleukin 6 Homo sapiens 82-86 27210890-7 2016 KEY FINDINGS: RA significantly inhibited poly(I:C)-induced expression of inflammatory cytokines including IL-1beta, IL-6, IL-8, CCL20, and TNF-alpha, and downregulated NF-kappaB signaling pathway in human keratinocytes. rosmarinic acid 14-16 interleukin 6 Homo sapiens 116-120 27206886-11 2016 IL6 was significantly increased 3h following IFNss-1a injection and exercise compared to 1h post and pre and when compared to the resting condition. Tritium 32-34 interleukin 6 Homo sapiens 0-3 27258042-4 2016 Novel highly specific Syk inhibitor AB8779 suppressed IFN-alpha, TNF-alpha and IL-6 production induced by TLR7/9 agonists in primary pDCs and in the pDC cell line GEN2.2. ab8779 36-42 interleukin 6 Homo sapiens 79-83 27278808-15 2016 CONCLUSIONS: Pulmonary exposure to ZnO-coated MWCNTs produces a systemic acute phase response that involves the release of Zn(+2), lung epithelial growth arrest, and increased IL-6. Zinc 35-37 interleukin 6 Homo sapiens 176-180 26104857-0 2016 Synergistic augmentation of ATP-induced interleukin-6 production by arsenite in HaCaT cells. Adenosine Triphosphate 28-31 interleukin 6 Homo sapiens 40-53 27056727-9 2016 Hydrocortisone significantly attenuated IL-1beta-induced inflammatory responses in the immature human gut when administered at the time of the proinflammatory insult: IL-1beta-induced IL-8 and IL-6 secretion in the fetal ileum as well as H4 cells were significantly reduced. Hydrocortisone 0-14 interleukin 6 Homo sapiens 193-197 27272805-6 2016 C-reactive protein (CRP) and interleukin-6 (IL-6) correlated with each other and exhibited positive correlation with age, body-mass index (BMI), leukocyte count, platelet count, kynurenine, kynurenine/tryptophan ratio and urinary neopterin and a negative correlation with vitamin D and retinol. Tryptophan 201-211 interleukin 6 Homo sapiens 29-42 27272805-6 2016 C-reactive protein (CRP) and interleukin-6 (IL-6) correlated with each other and exhibited positive correlation with age, body-mass index (BMI), leukocyte count, platelet count, kynurenine, kynurenine/tryptophan ratio and urinary neopterin and a negative correlation with vitamin D and retinol. Tryptophan 201-211 interleukin 6 Homo sapiens 44-48 27272805-6 2016 C-reactive protein (CRP) and interleukin-6 (IL-6) correlated with each other and exhibited positive correlation with age, body-mass index (BMI), leukocyte count, platelet count, kynurenine, kynurenine/tryptophan ratio and urinary neopterin and a negative correlation with vitamin D and retinol. Vitamin D 272-281 interleukin 6 Homo sapiens 29-42 27272805-6 2016 C-reactive protein (CRP) and interleukin-6 (IL-6) correlated with each other and exhibited positive correlation with age, body-mass index (BMI), leukocyte count, platelet count, kynurenine, kynurenine/tryptophan ratio and urinary neopterin and a negative correlation with vitamin D and retinol. Vitamin D 272-281 interleukin 6 Homo sapiens 44-48 26104857-9 2016 Our results suggest that As(III) augments ATP-induced IL-6 production in HaCaT cells through enhanced phosphorylation of the EGFR and p38/ERK pathways, which is associated with the inhibition of PTPs activity. Adenosine Triphosphate 42-45 interleukin 6 Homo sapiens 54-58 26104857-3 2016 Because extracellular ATP and interleukin-6 (IL-6) are involved in pathological aspects of cutaneous diseases, we examined whether sodium arsenite (As(III)) affects ATP-induced IL-6 production in human epidermal keratinocyte HaCaT cells. Adenosine Triphosphate 165-168 interleukin 6 Homo sapiens 177-181 26104857-4 2016 The results showed that the addition of As(III) into the medium of HaCaT cells dose dependently increased the production of IL-6 induced by extracellular ATP, although As(III) alone had no effect on IL-6 production. as(iii) 40-47 interleukin 6 Homo sapiens 124-128 26104857-4 2016 The results showed that the addition of As(III) into the medium of HaCaT cells dose dependently increased the production of IL-6 induced by extracellular ATP, although As(III) alone had no effect on IL-6 production. Adenosine Triphosphate 154-157 interleukin 6 Homo sapiens 124-128 26104857-5 2016 To elucidate the mechanism of the synergistic effect of As(III) on IL-6 production by extracellular ATP, we next examined the phosphorylation of p38, ERK and epidermal growth factor receptor (EGFR), since we found that these signaling molecules were stimulated by exposure to extracellular ATP. as(iii) 56-63 interleukin 6 Homo sapiens 67-71 26104857-5 2016 To elucidate the mechanism of the synergistic effect of As(III) on IL-6 production by extracellular ATP, we next examined the phosphorylation of p38, ERK and epidermal growth factor receptor (EGFR), since we found that these signaling molecules were stimulated by exposure to extracellular ATP. Adenosine Triphosphate 100-103 interleukin 6 Homo sapiens 67-71 27009878-7 2016 Treatment of HIF inhibitor (FM19G11) abolished the upregulation of CSC markers and increased sphere formations in IL-6 expressing cells on cisplatin treatment. Cisplatin 139-148 interleukin 6 Homo sapiens 114-118 27274108-4 2016 Interleukin-6 (IL-6) released from the exercising muscles may be involved in the acute adaptations of glucose metabolism after CE and non-muscle-damaging EE. Glucose 102-109 interleukin 6 Homo sapiens 0-13 27274108-4 2016 Interleukin-6 (IL-6) released from the exercising muscles may be involved in the acute adaptations of glucose metabolism after CE and non-muscle-damaging EE. Glucose 102-109 interleukin 6 Homo sapiens 15-19 27009878-0 2016 Cisplatin treatment increases stemness through upregulation of hypoxia-inducible factors by interleukin-6 in non-small cell lung cancer. Cisplatin 0-9 interleukin 6 Homo sapiens 92-105 27009878-8 2016 In all, IL-6-mediated HIF upregulation is important in increasing stemness during cisplatin resistance development, and we suggest that the strategies of inhibiting IL-6 signaling or its downstream HIF molecules can be used as future therapeutic approaches to target CSCs after cisplatin treatment for lung cancer. Cisplatin 82-91 interleukin 6 Homo sapiens 8-12 27009878-3 2016 When A549CisR and H157CisR cells were treated with neutralizing IL-6 antibody, decreased cisplatin resistance was observed, whereas IL-6 treatment of parental cells resulted in increased cisplatin resistance. Cisplatin 89-98 interleukin 6 Homo sapiens 64-68 27009878-3 2016 When A549CisR and H157CisR cells were treated with neutralizing IL-6 antibody, decreased cisplatin resistance was observed, whereas IL-6 treatment of parental cells resulted in increased cisplatin resistance. Cisplatin 187-196 interleukin 6 Homo sapiens 132-136 27009878-8 2016 In all, IL-6-mediated HIF upregulation is important in increasing stemness during cisplatin resistance development, and we suggest that the strategies of inhibiting IL-6 signaling or its downstream HIF molecules can be used as future therapeutic approaches to target CSCs after cisplatin treatment for lung cancer. Cisplatin 278-287 interleukin 6 Homo sapiens 8-12 27009878-5 2016 Hypoxia inducible factors (HIFs) were upregulated by IL-6 and responsible for the increased CSC stemness on cisplatin treatment. Cisplatin 108-117 interleukin 6 Homo sapiens 53-57 27170049-9 2016 Histamine stimulated the production of IL-6, IL-8 and CCL2 by orbital fibroblasts, while it had no effect on the production of CCL5, CCL7, CXCL10, CXCL11 and hyaluronan. Histamine 0-9 interleukin 6 Homo sapiens 39-43 27197152-4 2016 Mechanistic investigations indicated that these effects relied upon cross-talk between the STAT3 and NOTCH pathways in cancer cells, with MDSC inducing IL6-dependent phosphorylation of STAT3 and activating NOTCH through nitric oxide leading to prolonged STAT3 activation. Nitric Oxide 220-232 interleukin 6 Homo sapiens 152-155 27043288-7 2016 The cytokines interleukin-6, interleukin-1RA, TGF-beta and sTNF-R2 were associated with CRF in patients receiving anthracycline-based chemotherapy. Anthracyclines 114-127 interleukin 6 Homo sapiens 14-27 27170049-10 2016 Orbital fibroblasts expressed HRH1 and loratadine and SC-514 both blocked histamine-induced IL-6, IL-8 and CCL2 production by orbital fibroblasts. Histamine 74-83 interleukin 6 Homo sapiens 92-96 27037808-7 2016 Both norepinephrine and dobutamine significantly reduced TNF-alpha and IL-6 production after ex vivo LPS stimulation of whole blood in a dose-dependent manner, and this effect was partially reversed by the presence of metoprolol. Norepinephrine 5-19 interleukin 6 Homo sapiens 71-75 27020594-9 2016 CONCLUSIONS: In children with community-acquired pneumonia, use of sevoflurane was associated with lower circulating IL-6 and IL-10 levels compared with propofol, following FFB. Sevoflurane 67-78 interleukin 6 Homo sapiens 117-121 26641976-12 2016 Tryptophan showed a moderate degree of anti-inflammatory activity against TNF-alpha and IL-6. Tryptophan 0-10 interleukin 6 Homo sapiens 88-92 27350635-7 2016 RESULTS: The mean absorbance of 10 out of the 12 studied cytokines showed reduction after the therapy with rapamycin including IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, IL-13, IL-17, IFN-gamma and TNF-alpha. Sirolimus 107-116 interleukin 6 Homo sapiens 145-149 27382387-7 2016 Additionally, increased release of ROS and the expression of pro-inflammatory cytokines, such as interleukin 6 and tumor necrosis factor alpha, confirmed that the proliferation was induced by the ROS-linked inflammatory response in breast cancer. Reactive Oxygen Species 196-199 interleukin 6 Homo sapiens 97-142 27020594-7 2016 IL-6 levels were significantly lower in the sevoflurane group than propofol group at 4 h and 1 d following FFB (61.3 +- 11.9 versus 82.6 +- 19.7 pg/ml; 52.8 +- 9.7 versus 75.4 +- 13.6 pg/ml, respectively). Sevoflurane 44-55 interleukin 6 Homo sapiens 0-4 26929249-0 2016 Chikusetsusaponin IVa Butyl Ester (CS-IVa-Be), a Novel IL6R Antagonist, Inhibits IL6/STAT3 Signaling Pathway and Induces Cancer Cell Apoptosis. SEC-BUTYL ACETATE 22-33 interleukin 6 Homo sapiens 55-58 26929249-6 2016 Further studies indicated that CS-IVa-Be is an antagonist of IL6 receptor via directly binding to the IL6Ralpha with a Kd of 663 +- 74 nmol/L and the GP130 (IL6Rbeta) with a Kd of 1,660 +- 243 nmol/L, interfering with the binding of IL6 to IL6R (IL6Ralpha and GP130) in vitro and in cancer cells. Beryllium 37-40 interleukin 6 Homo sapiens 61-64 26929249-6 2016 Further studies indicated that CS-IVa-Be is an antagonist of IL6 receptor via directly binding to the IL6Ralpha with a Kd of 663 +- 74 nmol/L and the GP130 (IL6Rbeta) with a Kd of 1,660 +- 243 nmol/L, interfering with the binding of IL6 to IL6R (IL6Ralpha and GP130) in vitro and in cancer cells. Beryllium 37-40 interleukin 6 Homo sapiens 102-105 26687643-0 2016 Resveratrol reduces IL-6 and VEGF secretion from co-cultured A549 lung cancer cells and adipose-derived mesenchymal stem cells. Resveratrol 0-11 interleukin 6 Homo sapiens 20-24 27108527-0 2016 Increased interleukin-6 expression is associated with poor prognosis and acquired cisplatin resistance in head and neck squamous cell carcinoma. Cisplatin 82-91 interleukin 6 Homo sapiens 10-23 27108527-3 2016 Similar tendency was observed in platinum treated patients, suggesting an IL-6 associated cisplatin resistance. Platinum 33-41 interleukin 6 Homo sapiens 74-78 27108527-3 2016 Similar tendency was observed in platinum treated patients, suggesting an IL-6 associated cisplatin resistance. Cisplatin 90-99 interleukin 6 Homo sapiens 74-78 27108527-4 2016 IL-6 increase was also found in two in-house acquired cisplatin-resistant HNSCC cell lines (both basaloid and conventional squamous cell carcinoma) by using microarray analysis. Cisplatin 54-63 interleukin 6 Homo sapiens 0-4 27108527-5 2016 However, although the in-house acquired cisplatin-resistant cell lines had higher basal and markedly increased cisplatin-induced IL-6 expression, IL-6 did not mediate the cisplatin resistance as neither exogenous IL-6 nor IL-6R/gp130 inhibitors affected cisplatin sensitivity. Cisplatin 40-49 interleukin 6 Homo sapiens 129-133 27108527-5 2016 However, although the in-house acquired cisplatin-resistant cell lines had higher basal and markedly increased cisplatin-induced IL-6 expression, IL-6 did not mediate the cisplatin resistance as neither exogenous IL-6 nor IL-6R/gp130 inhibitors affected cisplatin sensitivity. Cisplatin 111-120 interleukin 6 Homo sapiens 129-133 27108527-5 2016 However, although the in-house acquired cisplatin-resistant cell lines had higher basal and markedly increased cisplatin-induced IL-6 expression, IL-6 did not mediate the cisplatin resistance as neither exogenous IL-6 nor IL-6R/gp130 inhibitors affected cisplatin sensitivity. Cisplatin 111-120 interleukin 6 Homo sapiens 129-133 27108527-5 2016 However, although the in-house acquired cisplatin-resistant cell lines had higher basal and markedly increased cisplatin-induced IL-6 expression, IL-6 did not mediate the cisplatin resistance as neither exogenous IL-6 nor IL-6R/gp130 inhibitors affected cisplatin sensitivity. Cisplatin 111-120 interleukin 6 Homo sapiens 129-133 27108527-7 2016 Thus, high IL-6 expression correlated to poor prognosis and acquired cisplatin resistance, but it did not mediate cisplatin resistance in the HNSCC cell lines. Cisplatin 69-78 interleukin 6 Homo sapiens 11-15 28901078-5 2016 Compared with PM2.5 group, puerarin increased the cells survival rate, down-regulated p-ERK1/2 protein level and Bax/Bcl-2 ratio in a dose dependent manner to inhibit the apoptosis; decreased the contents of TNF-alpha, IL-6 and MDA, the activity of LDH, but increased SOD activity in the EA.hy926 cells (P<0.05). puerarin 27-35 interleukin 6 Homo sapiens 219-223 27091428-0 2016 17beta-estradiol exerts anticancer effects in anoikis-resistant hepatocellular carcinoma cell lines by targeting IL-6/STAT3 signaling. Estradiol 0-16 interleukin 6 Homo sapiens 113-117 27262804-5 2016 IL6, Caspase3, Bax1, P-JAK2, P-Stat3 and P-p38 expression was much higher than the control, and was notably decreasedby the application of 100mumol/L hydrogen. Hydrogen 150-158 interleukin 6 Homo sapiens 0-3 27262815-9 2016 The enhanced lactate contributed to TLR4 signaling activation, IL-6 and IL-8 generation, and cell viability promotion in MCF-7 cells. Lactic Acid 13-20 interleukin 6 Homo sapiens 63-67 27048653-6 2016 Importantly, small interfering RNA-mediated reduction of endogenous ARL3 expression decreased IL-6-induced tyrosine phosphorylation, nuclear accumulation, and transcriptional activity of STAT3. Tyrosine 107-115 interleukin 6 Homo sapiens 94-98 27193532-4 2016 Serum sodium levels were correlated negatively with ESR (p =0.001) and positively with serum albumin levels (p < 0.0001) and C3 (p = 0.008) in children with SLE and those levels were correlated negatively with serum interleukin-6 levels (p = 0.003) in adults with SLE. Sodium 6-12 interleukin 6 Homo sapiens 219-232 26940199-9 2016 Finally, ICC showed, after 24 hrs of CTLA4-Ig-DEX or CTLA4-Ig-DEX-MTX treatment a reduction (p<0.05) of IL-1beta and IL-6 expression, versus CNT; DEX alone reduced only IL-1beta (p<0.05). Dexamethasone 46-49 interleukin 6 Homo sapiens 120-124 27164082-7 2016 A partial silencing of Csf2 or eIF2alpha by RNA interference revealed that Interleukin-6 (IL6), Csf2, and Cyclooxygenase-2 (Cox2) are downregulated by guanabenz-driven phosphorylation of eIF2alpha. Guanabenz 151-160 interleukin 6 Homo sapiens 75-88 27164082-7 2016 A partial silencing of Csf2 or eIF2alpha by RNA interference revealed that Interleukin-6 (IL6), Csf2, and Cyclooxygenase-2 (Cox2) are downregulated by guanabenz-driven phosphorylation of eIF2alpha. Guanabenz 151-160 interleukin 6 Homo sapiens 90-93 26961863-6 2016 The secretion of IL-6 was dependent on reactive oxygen species (ROS) and NF-kappaB. Reactive Oxygen Species 39-62 interleukin 6 Homo sapiens 17-21 26961863-6 2016 The secretion of IL-6 was dependent on reactive oxygen species (ROS) and NF-kappaB. Reactive Oxygen Species 64-67 interleukin 6 Homo sapiens 17-21 26961818-6 2016 The results suggested that, compared with observed clinical data, changes in systemic exposure to multiple CYP substrates by anti-IL-6 treatment in virtual RA patients have been reasonably captured by the PBPK model, as manifested by modulations in area under plasma concentration versus time curves for midazolam, omeprazole, S-warfarin, and caffeine. Omeprazole 315-325 interleukin 6 Homo sapiens 130-134 26940199-9 2016 Finally, ICC showed, after 24 hrs of CTLA4-Ig-DEX or CTLA4-Ig-DEX-MTX treatment a reduction (p<0.05) of IL-1beta and IL-6 expression, versus CNT; DEX alone reduced only IL-1beta (p<0.05). Dexamethasone 62-65 interleukin 6 Homo sapiens 120-124 26930265-10 2016 Secretion of sFlt-1, sEng, and IL-6 was increased while VEGF and PIGF were decreased in CTB-treated >=150 mg/dl of glucose (*p < 0.01 for each). Glucose 118-125 interleukin 6 Homo sapiens 31-35 26960744-7 2016 Along with the lower levels of inflammatory cytokine gene expressions in the extract, treatment of the 2D IHOKs with Zn(2+) alone and treatment of the 3D IHOKs with Zn(2+) plus eugenol resulted in significantly lower expression levels of IL-1beta, IL-6, and IL-8 (P<0.05). Zinc 117-119 interleukin 6 Homo sapiens 248-252 26960744-7 2016 Along with the lower levels of inflammatory cytokine gene expressions in the extract, treatment of the 2D IHOKs with Zn(2+) alone and treatment of the 3D IHOKs with Zn(2+) plus eugenol resulted in significantly lower expression levels of IL-1beta, IL-6, and IL-8 (P<0.05). Zinc 165-167 interleukin 6 Homo sapiens 248-252 27168850-0 2016 Chlorogenic acid induces apoptosis to inhibit inflammatory proliferation of IL-6-induced fibroblast-like synoviocytes through modulating the activation of JAK/STAT and NF-kappaB signaling pathways. Chlorogenic Acid 0-16 interleukin 6 Homo sapiens 76-80 26876300-2 2016 In this study we evaluated the cytokine production and mRNA expression of IFN-gamma, TNF-alpha, IL-10&IL-6 stimulated with r32kDa M. bovis BCGAg in active pulmonary tuberculosis patients (APTB), household contacts (HHC) and healthy controls (HC). Adenosine Monophosphate 102-105 interleukin 6 Homo sapiens 106-110 26876300-6 2016 The IL-6 expression was 2.2 fold &1 fold less in APTB and HHC compared to HCs. Adenosine Monophosphate 34-37 interleukin 6 Homo sapiens 4-8 26268146-5 2016 The in vitro literature on antidepressants shows that some antidepressants, such as clomipramine and fluoxetine, more consistently decrease pro-inflammatory cytokines (interleukin (IL)-6, interferon (IFN)-gamma, tumour necrosis factor (TNF)-alpha), whilst others (mirtazapine and venlafaxine) tend to increase their levels. Clomipramine 84-96 interleukin 6 Homo sapiens 168-186 26947403-10 2016 RESULTS: Compared to control, H2O2-treated IEC-18 had reduced viability (p<0.01), lower GPx activity (p<0.01), higher TBARS levels (p<0.01), and increased IL6 and TNFalpha (p<0.001). Hydrogen Peroxide 30-34 interleukin 6 Homo sapiens 164-180 26947403-11 2016 Compared to H2O2-treated IEC-18, treatment with 0.2mM NaHS rescued viability (p<0.01), increased GPx activity (p<0.05), and reduced TBARS (p<0.01), IL6 and TNFalpha (p<0.001). sodium bisulfide 54-58 interleukin 6 Homo sapiens 157-173 26976796-5 2016 Aleglitazar, at concentrations as low as 10nmol/L, providing the half-maximal transcriptional activation of both PPARalpha and PPARgamma, reduced the stimulated expression of several pro-inflammatory mediators including interleukin (IL)-6, the chemokine CXC-L10, and monocyte chemoattractant protein (MCP)-1. aleglitazar 0-11 interleukin 6 Homo sapiens 220-238 27124181-9 2016 In addition, PGE2 inhibited the expression of inflammatory genes (i.e. IL-6 and MCP-1) in WAT explants as well as in adipocytes challenged with LPS. Dinoprostone 13-17 interleukin 6 Homo sapiens 71-75 27136576-7 2016 The expression of osteopontin, sclerostin, TNFalpha and IL6, known stimuli for decreasing osteoblast activity, were reduced with the addition of rutin or hyperoside. hyperoside 154-164 interleukin 6 Homo sapiens 56-59 26656061-10 2016 One IL-6-MMP3 genotype combination was associated with the susceptibility to IS. is 77-79 interleukin 6 Homo sapiens 4-13 27226903-5 2016 Significant involvement of pro-inflammatory cytokines-including interleukin (IL)-1beta, IL-6 and tumour necrosis factor-alpha-exacerbates the accumulation of oxidative damage products in the liver, such as malondialdehyde, fluorescent pigments and conjugated dienes. Malondialdehyde 206-221 interleukin 6 Homo sapiens 88-92 26774572-7 2016 Interestingly, ASP- and PROP-containing substrates not only showed reduced adhesion of platelets and delayed coagulation time, but also drastically reduced the expression level of IL-8 and IL-6. Aspirin 15-18 interleukin 6 Homo sapiens 189-193 27002382-6 2016 TE and betulin treatment led to increased mRNA levels of chemokines, pro-inflammatory cytokines, and mediators important in wound healing, e.g., IL-6, TNFalpha, IL-8, and RANTES. betulin 7-14 interleukin 6 Homo sapiens 145-149 26951799-4 2016 We demonstrate that ATP acting via the P2X7 receptor pathway promotes a Th17 polarizing microenvironment with high levels of IL-1beta, IL-6, and IL-17 in VAT explants from lean donors. Adenosine Triphosphate 20-23 interleukin 6 Homo sapiens 135-139 26794444-4 2016 Here, we showed that the repression of SOCS3 and sustained activation of IL-6/STAT3 pathway in HBV-producing HCC cells were caused by HBV-induced mitochondrial ROS accumulation. ros 160-163 interleukin 6 Homo sapiens 73-77 26794444-9 2016 Taken together, our data show that HBV-induced mitochondrial ROS production represses SOCS3 expression through Snail-mediated epigenetic silencing, leading to the sustained activation of IL-6/STAT3 pathway and ultimately contributing to hepatocarcinogenesis. ros 61-64 interleukin 6 Homo sapiens 187-191 27186470-1 2016 BACKGROUND: Carbohydrate ingestion during exercise is known to attenuate exercise-induced elevation of plasma IL-6 concentration. Carbohydrates 12-24 interleukin 6 Homo sapiens 110-114 27007849-7 2016 The ER stress inducers thapsigargin and dithiothreitol trigger production of the pro-inflammatory cytokine IL-6 in a NOD1/2-dependent fashion. Thapsigargin 23-35 interleukin 6 Homo sapiens 107-111 27104513-8 2016 Gallic acid and chlorogenic acid could suppress the release of pro-inflammatory cytokine IL-6 and chemokine CCL7 and CXCL8, respectively, in IL-31- and IL-33-treated eosinophils-dermal fibroblasts co-culture; while berberine could suppress the release of IL-6, CXCL8, CCL2 and CCL7 in the eosinophil culture and eosinophils-dermal fibroblasts co-culture (all p < 0.05). Chlorogenic Acid 16-32 interleukin 6 Homo sapiens 89-93 27104513-8 2016 Gallic acid and chlorogenic acid could suppress the release of pro-inflammatory cytokine IL-6 and chemokine CCL7 and CXCL8, respectively, in IL-31- and IL-33-treated eosinophils-dermal fibroblasts co-culture; while berberine could suppress the release of IL-6, CXCL8, CCL2 and CCL7 in the eosinophil culture and eosinophils-dermal fibroblasts co-culture (all p < 0.05). Chlorogenic Acid 16-32 interleukin 6 Homo sapiens 255-259 27104574-3 2016 Their ability to induce the production of cytokines TNFalpha, IL-1beta and IL-6 in phorbol-12-myristate-13-acetate (PMA)-treated U937 cells was assessed. Tetradecanoylphorbol Acetate 83-114 interleukin 6 Homo sapiens 75-79 27104574-3 2016 Their ability to induce the production of cytokines TNFalpha, IL-1beta and IL-6 in phorbol-12-myristate-13-acetate (PMA)-treated U937 cells was assessed. Tetradecanoylphorbol Acetate 116-119 interleukin 6 Homo sapiens 75-79 27007229-5 2016 Best platelet response to steroid treatment was found among GC genotype of IL-6 (-174) and GG genotype of IL-10 (-1082) in all patients with ITP. Steroids 26-33 interleukin 6 Homo sapiens 75-79 27007229-8 2016 IL-6 (-174) and IL-10 (-1082) genes might play a role in the effectiveness of steroid therapy among patients with ITP. Steroids 78-85 interleukin 6 Homo sapiens 0-4 27556306-9 2016 Recipients who required moderate/high levels of noradrenaline for weaning off cardiopulmonary bypass were associated with lower donor concentrations of sTNFR2 (P =0.028) and IL-6 (P =0.001). Norepinephrine 48-61 interleukin 6 Homo sapiens 174-178 25982417-8 2016 In stratified analyses, reduction in IL-6 levels occurs in surgical patients that received 0.2 g/kg of fish oil parenterally at postoperative period (SMD -0.65; 95% CI -1.06, -0.24; p = 0.002), while, increase in albumin concentration occurs in surgical patients that received >= 2.5 g/d of EPA + DHA orally at preoperative period (SMD 0.34; 95% CI 0.02, 0.66; p = 0.038). dehydroacetic acid 300-303 interleukin 6 Homo sapiens 37-41 27307657-7 2016 RESULTS: The data obtained from immunohistochemistry assessment shows that drug-induced gingival overgrowth (DIGO) samples express more IL-6 than control group and cyclosporin expresses more IL-6 followed by phenytoin and nifedipine. Cyclosporine 164-175 interleukin 6 Homo sapiens 191-195 27307657-9 2016 Among the study group, cyclosporin expressed maximum IL-6 expression followed by phenytoin and nifedipine. Cyclosporine 23-34 interleukin 6 Homo sapiens 53-57 26863424-6 2016 Serum RA levels were inversely associated with 8-iso-prostaglandin F2alpha (P < .001), high-sensitivity C-reactive protein (P = .015), and IL-6 (P = .020) and positively correlated with high-density lipoprotein cholesterol (P = .038). Tretinoin 6-8 interleukin 6 Homo sapiens 142-146 26849947-4 2016 Experiments from colonocyte incubation and intra-colonic instillation indicate that low millimolar concentrations of the sulfide donor NaHS reversibly inhibited colonocyte mitochondrial oxygen consumption and increased gene expression of hypoxia inducible factor 1alpha (Hif-1alpha) together with inflammation-related genes namely inducible nitric oxide synthase (iNos) and interleukin-6 (Il-6). Sulfides 121-128 interleukin 6 Homo sapiens 374-387 26849947-4 2016 Experiments from colonocyte incubation and intra-colonic instillation indicate that low millimolar concentrations of the sulfide donor NaHS reversibly inhibited colonocyte mitochondrial oxygen consumption and increased gene expression of hypoxia inducible factor 1alpha (Hif-1alpha) together with inflammation-related genes namely inducible nitric oxide synthase (iNos) and interleukin-6 (Il-6). Sulfides 121-128 interleukin 6 Homo sapiens 389-393 26849947-4 2016 Experiments from colonocyte incubation and intra-colonic instillation indicate that low millimolar concentrations of the sulfide donor NaHS reversibly inhibited colonocyte mitochondrial oxygen consumption and increased gene expression of hypoxia inducible factor 1alpha (Hif-1alpha) together with inflammation-related genes namely inducible nitric oxide synthase (iNos) and interleukin-6 (Il-6). sodium bisulfide 135-139 interleukin 6 Homo sapiens 374-387 26849947-4 2016 Experiments from colonocyte incubation and intra-colonic instillation indicate that low millimolar concentrations of the sulfide donor NaHS reversibly inhibited colonocyte mitochondrial oxygen consumption and increased gene expression of hypoxia inducible factor 1alpha (Hif-1alpha) together with inflammation-related genes namely inducible nitric oxide synthase (iNos) and interleukin-6 (Il-6). sodium bisulfide 135-139 interleukin 6 Homo sapiens 389-393 26921254-4 2016 Additionally,L-cys suppressed the LPS-induced intestinal inflammation and oxidative stress, as demonstrated by down-regulated TNF-alpha, IL-6 and IL-8 mRNA levels, increased catalase, superoxide dismutase, glutathione peroxidase activity, glutathione (GSH) contents and the ratio of GSH and oxidized glutathione in jejunum and ileum. Cysteine 13-18 interleukin 6 Homo sapiens 137-141 26739492-6 2016 In support, cultured adipocytes demonstrated IH-induced elevations of NADPH oxidase 4, phosphorylation of Erk, NF-kappaBp65, and inducible NOS (iNOS) and increased expression of IL-6 and MCP-1. Ile-His 45-47 interleukin 6 Homo sapiens 178-182 26467187-7 2016 Cannabinoid receptor activation by the specific synthetic agonists ACEA and JWH-133 (but not the endogenous agonist 2-arachidonoylglycerol) markedly inhibits LPS-induced production of vascular endothelial growth factor-A, vascular endothelial growth factor-C, and angiopoietins and modestly affects IL-6 secretion. 1,1-dimethylbutyl-1-deoxy-Delta(9)-THC 76-83 interleukin 6 Homo sapiens 299-303 26537370-8 2016 RESULTS: High glucose levels inhibited PDLSC proliferation and differentiation into osteoblasts but induced NF-kappaB activation and subsequent interleukin (IL)-6 and IL-8 expression. Glucose 14-21 interleukin 6 Homo sapiens 144-162 26537370-9 2016 Treatment with an NF-kappaB inhibitor rescued the defects in cell proliferation and osteoblastic differentiation and inhibited the IL-6 expression caused by the high-glucose environment. Glucose 166-173 interleukin 6 Homo sapiens 131-135 26924495-9 2016 Glucose fluctuation also resulted in up-regulating gene expression of pro-inflammatory mediators, interleukin-6 and intercellular adhesion molecule-1. Glucose 0-7 interleukin 6 Homo sapiens 98-149 27003097-4 2016 Like tofacitinib, tocilizumab, a biologic targeting the IL-6 pathway, has been approved for use in rheumatoid arthritis and interest in transplantation has been confined to several investigator-initiated trials. tofacitinib 5-16 interleukin 6 Homo sapiens 56-60 27186361-6 2016 Exendin-4 and glucose-dependent insulinotropic polypepide elicited cyclic adenosine monophosphate generation, and suppressed the lipopolysaccharide-induced gene expression of inflammatory molecules, such as interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha, in U937 human monocytes. Glucose 14-21 interleukin 6 Homo sapiens 226-271 26985948-9 2016 Presence of the IL-6 -174G/C SNP is significantly correlated with morphine equivalent daily dose. Morphine 66-74 interleukin 6 Homo sapiens 16-20 26918832-6 2016 Frequencies of IL-6-producing T cells were correlated with glucose levels after glucose-tolerance tests (but not body mass index and waist circumference) and inversely correlated with HGK expression levels. Glucose 59-66 interleukin 6 Homo sapiens 15-19 26963617-12 2016 In the SHR-CRP transgenic strain, we found that metformin treatment decreased circulating levels of inflammatory response marker IL-6, TNFalpha and MCP-1 while levels of human CRP remained unchanged. Metformin 48-57 interleukin 6 Homo sapiens 129-133 26918832-6 2016 Frequencies of IL-6-producing T cells were correlated with glucose levels after glucose-tolerance tests (but not body mass index and waist circumference) and inversely correlated with HGK expression levels. Glucose 80-87 interleukin 6 Homo sapiens 15-19 32263018-3 2016 This study demonstrated that conjugation of a corticosteroid (triamcinolone) on polyethylene-glycol (PEG)-fabricated multi-walled carbon nanotubes enhances intracellular drug delivery via increased lysosome transport and ultimately suppresses the expression of major pro-inflammatory cytokines (i.e., TNF-alpha, IL-1beta, and IL-6) and matrix metalloproteinase-1 and -3 from fibroblast-like synoviocytes at a very low drug dose. Polyethylene Glycols 80-99 interleukin 6 Homo sapiens 326-330 26926996-2 2016 Here, we report that in monocytes and macrophages of patients with atherosclerotic coronary artery disease (CAD), overutilization of glucose promotes excessive and prolonged production of the cytokines IL-6 and IL-1beta, driving systemic and tissue inflammation. Glucose 133-140 interleukin 6 Homo sapiens 202-206 32263018-3 2016 This study demonstrated that conjugation of a corticosteroid (triamcinolone) on polyethylene-glycol (PEG)-fabricated multi-walled carbon nanotubes enhances intracellular drug delivery via increased lysosome transport and ultimately suppresses the expression of major pro-inflammatory cytokines (i.e., TNF-alpha, IL-1beta, and IL-6) and matrix metalloproteinase-1 and -3 from fibroblast-like synoviocytes at a very low drug dose. Polyethylene Glycols 101-104 interleukin 6 Homo sapiens 326-330 32263018-3 2016 This study demonstrated that conjugation of a corticosteroid (triamcinolone) on polyethylene-glycol (PEG)-fabricated multi-walled carbon nanotubes enhances intracellular drug delivery via increased lysosome transport and ultimately suppresses the expression of major pro-inflammatory cytokines (i.e., TNF-alpha, IL-1beta, and IL-6) and matrix metalloproteinase-1 and -3 from fibroblast-like synoviocytes at a very low drug dose. Carbon 130-136 interleukin 6 Homo sapiens 326-330 25917060-11 2016 Interleukin-6 levels were lower at 6 and 24 hours post-operatively (p<0.001), and Interleukin-10 levels were higher 6 hours post-operatively (p<0.001) in the steroid group. Steroids 164-171 interleukin 6 Homo sapiens 0-13 26981446-5 2016 RESULTS: The ratio of the effluent level of creatinine (Cr) obtained 4 h after injection (D) to that of plasma was correlated with the effluent levels of MMP-2 (rho = 0.74, P < 0.001), IL-6 (rho = 0.46, P < 0.001), and hyaluronan (rho = 0.27, P < 0.001), but not CA125 (rho = 0.13, P = 0.051). Creatinine 44-54 interleukin 6 Homo sapiens 188-192 26981446-5 2016 RESULTS: The ratio of the effluent level of creatinine (Cr) obtained 4 h after injection (D) to that of plasma was correlated with the effluent levels of MMP-2 (rho = 0.74, P < 0.001), IL-6 (rho = 0.46, P < 0.001), and hyaluronan (rho = 0.27, P < 0.001), but not CA125 (rho = 0.13, P = 0.051). Creatinine 56-58 interleukin 6 Homo sapiens 188-192 26667403-10 2016 CRP, IL-6, and cortisol were significantly lower in the dexamethasone group compared with the control group during the 24 hours after UAE. Dexamethasone 56-69 interleukin 6 Homo sapiens 5-9 25917060-14 2016 CONCLUSION: Dexamethasone caused quantitative suppression of Interleukin-6 and increased Interleukin-10 activation, contributing to reduced immunopathology, but it did not translate into clinical benefit in the short term. Dexamethasone 12-25 interleukin 6 Homo sapiens 61-74 27031714-9 2016 Likewise, IL-6, which is a sensitive cytokine of CD40 activation, was significantly increased in HeLa(CD40) cells in the same experiments (2.7 fold after stimulation with BHK(CD40L) and 5.2 fold after stimulation with TNFalpha vs. control; p < 0.01 and p < 0.001, respectively). (2R)-2-benzyl-5-hydroxy-4-oxopentanoic acid 171-174 interleukin 6 Homo sapiens 10-14 26775040-4 2016 In this study, we found that IL6 stimulation markedly increased intracellualr pH recovery rates of human HCC cells, Huh7 and HepG2, after NH4Cl acidification, and the NH4Cl acidification induced transient intracellular Ca(2+) increases in the HCC cells. Ammonium Chloride 138-143 interleukin 6 Homo sapiens 29-32 26775040-4 2016 In this study, we found that IL6 stimulation markedly increased intracellualr pH recovery rates of human HCC cells, Huh7 and HepG2, after NH4Cl acidification, and the NH4Cl acidification induced transient intracellular Ca(2+) increases in the HCC cells. Ammonium Chloride 167-172 interleukin 6 Homo sapiens 29-32 26370214-8 2016 MWCNTs-COOH induced interleukin-6 (IL-6) and IL-8 release in A549 cells whereas p-MWCNTs induced IL-8 release in BEAS-2B cells. Carbonic Acid 7-11 interleukin 6 Homo sapiens 20-33 26850862-16 2016 CONCLUSIONS: Positive BAC is associated with reduced leukocyte numbers and lowered systemic IL-6 levels at admittance indicating immune-suppressive effects of alcohol in major trauma patients. Alcohols 159-166 interleukin 6 Homo sapiens 92-96 26803522-7 2016 Meanwhile, a reduction in the serum levels of IL-1beta, MDA and S-100B was noticed in progesterone group 24h after injury (P<0.05, P<0.001 and P<0.05, respectively), and there was an increase in serum levels of IL-6 and TGF-beta1 (P<0.01 and P<0.05, respectively). Progesterone 86-98 interleukin 6 Homo sapiens 220-224 26803523-8 2016 Acanthoic acid also inhibited TNF-alpha-induced IL-8 and IL-6 production. acanthoic acid 0-14 interleukin 6 Homo sapiens 57-61 26370214-8 2016 MWCNTs-COOH induced interleukin-6 (IL-6) and IL-8 release in A549 cells whereas p-MWCNTs induced IL-8 release in BEAS-2B cells. Carbonic Acid 7-11 interleukin 6 Homo sapiens 35-39 26290259-8 2016 Significant correlations were observed among IL-6, bone morphogenetic protein 6, hepcidin and ferroportin, as regards systemic iron regulation. Iron 127-131 interleukin 6 Homo sapiens 45-49 26361990-11 2016 Interleukin-6 and -8 production, induced by 100muM SM was reduced by GSH/NAC. Glutathione 69-72 interleukin 6 Homo sapiens 0-20 26796050-5 2016 The results demonstrated that a high concentration of calcium ions in seawater increased lung tissue myeloperoxidase activity and the secretion of inflammatory mediators, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-1beta and IL-6. Calcium 54-61 interleukin 6 Homo sapiens 250-254 26930567-5 2016 The active form of vitamin D (calcitriol) restored the SLE MAC phenotype towards that of healthy subjects with reduced IL-6 secretion, and normalised surface marker expression. Vitamin D 19-28 interleukin 6 Homo sapiens 119-123 26923510-2 2016 We hypothesized that inflammatory markers interleukin (IL)-6 and C-reactive protein (CRP) mediate the associations between antioxidant and fatty acid intakes, and depression. Fatty Acids 139-149 interleukin 6 Homo sapiens 42-60 26741414-16 2016 Norepinephrine aggravated interleukin-6 upregulation in males in an extracellular signal-regulated kinase mitogen-activated protein kinase-dependent mechanism but blocked interleukin-6 up-regulation in females after fluid percussion injury. Norepinephrine 0-14 interleukin 6 Homo sapiens 26-39 26741414-16 2016 Norepinephrine aggravated interleukin-6 upregulation in males in an extracellular signal-regulated kinase mitogen-activated protein kinase-dependent mechanism but blocked interleukin-6 up-regulation in females after fluid percussion injury. Norepinephrine 0-14 interleukin 6 Homo sapiens 171-184 26741414-17 2016 Norepinephrine augments loss of neurons in CA1 and CA3 hippocampus of male piglets after fluid percussion injury in an extracellular signal-regulated kinase mitogen-activated protein kinase-dependent and interleukin-6-dependent manner but prevents loss of neurons in females after fluid percussion injury. Norepinephrine 0-14 interleukin 6 Homo sapiens 204-217 26741414-18 2016 CONCLUSION: Norepinephrine protects autoregulation and limits hippocampal neuronal cell necrosis via modulation of extracellular signal-regulated kinase mitogen-activated protein kinase and interleukin-6 after fluid percussion injury in a sex-dependent manner. Norepinephrine 12-26 interleukin 6 Homo sapiens 190-203 26597704-3 2016 In this study, we found that the low-affinity leukotriene B4 receptor-2 (BLT2) and its ligand leukotriene B4 were highly up-regulated in cisplatin-resistant SK-OV-3 ovarian cancer cells and play critical roles in mediating the chemoresistance through the activation of signal transducer and activator of transcription-3 (STAT-3) and the subsequent up-regulation of interleukin-6 (IL-6). Cisplatin 137-146 interleukin 6 Homo sapiens 365-378 26911440-2 2016 The cytokine interleukin-6 may impact on glucose homeostasis. Glucose 41-48 interleukin 6 Homo sapiens 13-26 26896068-9 2016 Moreover, metformin enhanced the anti-inflammatory effect of 5-ASA by decreasing the gene expression of IL-1beta, IL-6, COX-2 and TNF-alpha and its receptors; TNF-R1 and TNF-R2. Metformin 10-19 interleukin 6 Homo sapiens 114-118 26896068-9 2016 Moreover, metformin enhanced the anti-inflammatory effect of 5-ASA by decreasing the gene expression of IL-1beta, IL-6, COX-2 and TNF-alpha and its receptors; TNF-R1 and TNF-R2. Mesalamine 61-66 interleukin 6 Homo sapiens 114-118 26879559-6 2016 Inhibition of mTOR signaling with rapamycin, an mTOR signaling inhibitor, disturbed PGRN- or IL-6-mediated proliferation, migration and invasion of HCC cells in vitro. Sirolimus 34-43 interleukin 6 Homo sapiens 93-97 26820672-10 2016 In addition, the groups treated with SSP and beta-carotene showed significantly reduced levels of tumor necrosis factor-alpha and interleukin-6 compared with the control group. ssp 37-40 interleukin 6 Homo sapiens 130-143 26845700-10 2016 Addition of Zn also increased the production of IL-6, thus further stimulating the inflammatory response. Zinc 12-14 interleukin 6 Homo sapiens 48-52 26809098-0 2016 A soluble form of the interleukin-6 family signal transducer gp130 is dimerized via a C-terminal disulfide bridge resulting from alternative mRNA splicing. Disulfides 97-106 interleukin 6 Homo sapiens 22-35 26586196-7 2016 The splenic expression levels of IL-2 and IL-4 were up-regulated, whereas that of IL-6 was down-regulated, in the 100- and 150-microg folic acid treatment groups. Folic Acid 134-144 interleukin 6 Homo sapiens 82-86 26586196-9 2016 In contrast, a decrease in H3K4m2 and an increase in H3K9me2 were observed in the IL-6 promoter in folic acid treatments. Folic Acid 99-109 interleukin 6 Homo sapiens 82-86 26611525-9 2016 Aspect of patients, 0.45% NaCl group and 0.9% NaCl+ambroxol group were significantly different in the levels of SP-A, IL-6, IL-8 and TNF-alpha (P<0.01). Sodium Chloride 26-30 interleukin 6 Homo sapiens 118-122 26611525-9 2016 Aspect of patients, 0.45% NaCl group and 0.9% NaCl+ambroxol group were significantly different in the levels of SP-A, IL-6, IL-8 and TNF-alpha (P<0.01). Sodium Chloride 46-50 interleukin 6 Homo sapiens 118-122 26849353-7 2016 Results from group analysis suggested that high IL-6 levels in PCOS were significantly associated with Homeostasis Model Assessment of Insulin Resistance (HOMA2-IR) ratio and total testosterone ratio (T ratio), and was found in both lean and obese women with PCOS. Testosterone 181-193 interleukin 6 Homo sapiens 48-52 26893580-7 2016 RESULTS: In eight of nine ERalpha-positive breast cancer cell lines, recombinant IL-6 increased phosphorylation of tyrosine 705 of STAT3. Tyrosine 115-123 interleukin 6 Homo sapiens 81-85 26597704-3 2016 In this study, we found that the low-affinity leukotriene B4 receptor-2 (BLT2) and its ligand leukotriene B4 were highly up-regulated in cisplatin-resistant SK-OV-3 ovarian cancer cells and play critical roles in mediating the chemoresistance through the activation of signal transducer and activator of transcription-3 (STAT-3) and the subsequent up-regulation of interleukin-6 (IL-6). Leukotrienes 46-57 interleukin 6 Homo sapiens 365-378 26597704-3 2016 In this study, we found that the low-affinity leukotriene B4 receptor-2 (BLT2) and its ligand leukotriene B4 were highly up-regulated in cisplatin-resistant SK-OV-3 ovarian cancer cells and play critical roles in mediating the chemoresistance through the activation of signal transducer and activator of transcription-3 (STAT-3) and the subsequent up-regulation of interleukin-6 (IL-6). Leukotrienes 46-57 interleukin 6 Homo sapiens 380-384 26597704-3 2016 In this study, we found that the low-affinity leukotriene B4 receptor-2 (BLT2) and its ligand leukotriene B4 were highly up-regulated in cisplatin-resistant SK-OV-3 ovarian cancer cells and play critical roles in mediating the chemoresistance through the activation of signal transducer and activator of transcription-3 (STAT-3) and the subsequent up-regulation of interleukin-6 (IL-6). Cisplatin 137-146 interleukin 6 Homo sapiens 380-384 26501345-1 2016 PURPOSE: To examine the effect of post-resistance exercise alcohol ingestion on lipopolysaccharide (LPS)-stimulated production of IFNgamma, TNF-alpha, IL-1beta, IL-6, IL-8, and IL-10. Alcohols 59-66 interleukin 6 Homo sapiens 161-165 26725028-3 2016 5-Isoxazolyl-L-cyclohexylalanine-L-isoleucine-2-methoxybenzylamine (10) inhibited PAR2-, but not PAR1-, induced release of Ca(2+) (IC50 0.5 muM) in human colon cells, IL-6 and TNFalpha secretion (IC50 1-5 muM) from human kidney cells, and was anti-inflammatory in acute rat paw inflammation (ED50 5 mg/kg sc). 5-isoxazolyl-l-cyclohexylalanine-l-isoleucine-2-methoxybenzylamine 0-66 interleukin 6 Homo sapiens 167-171 26526647-5 2016 Higher levels of reflection predicted lower IL-6 responses 1h after the stressor. Hydrogen 59-61 interleukin 6 Homo sapiens 44-48 26501345-8 2016 Alcohol ingestion after resistance exercise affected aspects of inflammatory capacity (IL-6 and IL-8 production). Alcohols 0-7 interleukin 6 Homo sapiens 87-91 26277356-0 2016 Ghrelin Inhibits Interleukin-6 Production Induced by Cigarette Smoke Extract in the Bronchial Epithelial Cell Via NF-kappaB Pathway. Ghrelin 0-7 interleukin 6 Homo sapiens 17-30 26924930-4 2016 In present study, agmatine attenuated the cell death and the expression of pro-inflammatory cytokines such as IL-6, TNF-alpha and CCL2 in high glucose in vitro conditions. Glucose 143-150 interleukin 6 Homo sapiens 110-114 26277356-2 2016 The present study was designed to evaluate whether ghrelin, a novel growth hormone-releasing peptide, can affect the pro-inflammatory cytokine interleukin-6 (IL-6) production induced by cigarette smoke extract (CSE) in the human bronchial epithelial cell line (16-HBE) and its possible mechanism. Ghrelin 51-58 interleukin 6 Homo sapiens 143-156 26277356-2 2016 The present study was designed to evaluate whether ghrelin, a novel growth hormone-releasing peptide, can affect the pro-inflammatory cytokine interleukin-6 (IL-6) production induced by cigarette smoke extract (CSE) in the human bronchial epithelial cell line (16-HBE) and its possible mechanism. Ghrelin 51-58 interleukin 6 Homo sapiens 158-162 26277356-8 2016 Ghrelin suppressed CSE-induced IL-6 production at both mRNA and protein levels in a concentration-dependent manner (P < 0.05). Ghrelin 0-7 interleukin 6 Homo sapiens 31-35 26277356-10 2016 Together, these results suggest that ghrelin inhibits CSE-induced IL-6 production in 16-HBE cells by targeting on NF-kappaB pathway, but not by scavenging intracellular ROS. Ghrelin 37-44 interleukin 6 Homo sapiens 66-70 26808546-10 2016 Among all patients, elevated levels of interleukin-8 (IL-8), carcinoembryonic antigen (CEA), hypoxia-inducible factor 1-alpha (HIF-1 alpha), and interleukin-6 were independently associated with lower OS, while IL-8, CEA, platelet-derived growth factor receptor alpha and mucin-1 were associated with metastatic disease. Osmium 200-202 interleukin 6 Homo sapiens 145-158 27042444-12 2016 Our study shows Negative Correlation between MDA and SOD in case & control groups, while a Positive Correlation between TNF alpha and IL-6 in control & case groups. Adenosine Monophosphate 155-158 interleukin 6 Homo sapiens 138-142 26394816-5 2016 17-beta-Estradiol inhibits the LPS-induced IL-6 inflammatory response, resulting in inhibition of NF-kappaB transcriptional activity. Estradiol 0-17 interleukin 6 Homo sapiens 43-47 26721307-6 2016 In general, EtOH decreased secretion of IP-10, IL-6, eotaxin, GCSF, and MCP-1. Ethanol 12-16 interleukin 6 Homo sapiens 47-51 26568029-7 2016 In addition, IL-6 has direct impact on glucose and lipid metabolism. Glucose 39-46 interleukin 6 Homo sapiens 13-17 26735612-4 2016 Furthermore, melatonin enhances splenic interleukin (IL)-10 expression in regulatory T cells by inducing IL-27 expression in the splenic DC; it also suppresses the expression of IFN-gamma, IL-17, IL-6, and CCL20 in the CNS and inhibits antigen-specific T cell proliferation. Melatonin 13-22 interleukin 6 Homo sapiens 196-200 26767086-7 2016 We are also presenting lab data of the IL-6 secretions on exposure to DOX in one of the most commonly used TNBC cell lines MDA-MB-231. Doxorubicin 70-73 interleukin 6 Homo sapiens 39-43 26767086-8 2016 Breast cancer cell line MDA-MB-231 upon exposure to DOX shows an increase in IL-6 levels more than the already elevated IL-6 levels. Doxorubicin 52-55 interleukin 6 Homo sapiens 77-81 26767086-8 2016 Breast cancer cell line MDA-MB-231 upon exposure to DOX shows an increase in IL-6 levels more than the already elevated IL-6 levels. Doxorubicin 52-55 interleukin 6 Homo sapiens 120-124 26499872-4 2016 Further experiments demonstrated that the TNF-alpha-dependent generation of reactive oxygen species, down-regulation of adherens/tight junction proteins, and concomitant elevation of HBMvEC permeability, were all significantly attenuated by blockade of IL-6 signalling using either an anti-IL-6 neutralizing antibody or an IL-6 siRNA. Reactive Oxygen Species 76-99 interleukin 6 Homo sapiens 253-257 26499872-9 2016 We demonstrate that the TNF-alpha-dependent generation of reactive oxygen species (ROS), down-regulation of interendothelial junctions, and concomitant elevation of HBMvEC permeability, could be significantly attenuated by using either an IL-6 neutralizing antibody or an IL-6-specific siRNA. Reactive Oxygen Species 58-81 interleukin 6 Homo sapiens 239-243 25524404-6 2016 Interleukin-6 (IL-6) was significantly higher in the vitamin D deficient group compared with the sufficient group (medians: 0.36 vs. 0.18) (p = 0.026), whereas neither C-reactive protein (CRP) nor tumor necrosis factor-alpha (TNF-alpha) differed. Vitamin D 53-62 interleukin 6 Homo sapiens 0-13 25524404-6 2016 Interleukin-6 (IL-6) was significantly higher in the vitamin D deficient group compared with the sufficient group (medians: 0.36 vs. 0.18) (p = 0.026), whereas neither C-reactive protein (CRP) nor tumor necrosis factor-alpha (TNF-alpha) differed. Vitamin D 53-62 interleukin 6 Homo sapiens 15-19 26694802-6 2016 RA significantly reduced the production of tumor necrosis factor-alpha, IL-1beta, and IL-6 on the TSLP-stimulated HMC-1 cells. rosmarinic acid 0-2 interleukin 6 Homo sapiens 86-90 26789270-7 2016 Tbeta4 activation with a Tbeta4 peptide attenuated the H2O2-induced production of NO and PGE2 and up-regulated iNOS, COX-2, and osteoclastogenic cytokines (TNF-alpha, IL-1beta, IL-6, IL-8, and IL-17) as well as reversed the effect on RANKL and OPG in PDLCs. Hydrogen Peroxide 55-59 interleukin 6 Homo sapiens 177-181 27042306-4 2016 Additional in vitro studies of human peripheral blood mononuclear cells (PBMCs) exposed to high glucose confirmed decreased IL-6 expression, most prominently in CD14(+)CD16(+) intermediate monocytes. Glucose 96-103 interleukin 6 Homo sapiens 124-128 26353790-10 2016 In PsA explant, tofacitinib significantly decreased spontaneous secretion of IL-6, IL-8, MCP-1, MMP9/MMP2, MMP3 (all p<0.05) and decreased the MMP3/TIMP3 ratio (p<0.05), with no effect observed for IP-10 or IL-10. tofacitinib 16-27 interleukin 6 Homo sapiens 77-81 26670944-2 2016 Doxorubicin anticancer drug was physically loaded onto G4.5-IL6 and G4.5-RGD with the encapsulation efficiency of 51.3 and 30.1% respectively. Doxorubicin 0-11 interleukin 6 Homo sapiens 60-63 26670944-3 2016 The cellular internalization and uptake efficiency of G4.5-IL6/DOX and G4.5-RGD/DOX complexes was observed and compared by confocal microscopy and flow cytometry using HeLa cells, respectively. Doxorubicin 63-66 interleukin 6 Homo sapiens 59-62 27003399-4 2016 Similarly, adiponectin, leptin and IL-6 enhance glucose uptake and increase fatty acid oxidation in skeletal muscle. Glucose 48-55 interleukin 6 Homo sapiens 35-39 27003399-4 2016 Similarly, adiponectin, leptin and IL-6 enhance glucose uptake and increase fatty acid oxidation in skeletal muscle. Fatty Acids 76-86 interleukin 6 Homo sapiens 35-39 26670944-4 2016 The lower IC50 value of G4.5-IL6/DOX in comparison to G4.5-RGD/DOX is indication that higher drug loading and faster drug release rate corresponded with greater cytotoxicity. Doxorubicin 33-36 interleukin 6 Homo sapiens 29-32 26670944-6 2016 On the basis of these results, G4.5-IL6 is a better suited carrier for targeted drug delivery of DOX to cervical cancer cells. Doxorubicin 97-100 interleukin 6 Homo sapiens 36-39 26759169-8 2016 However, MSC pretreatment with cisplatin led to changes in phosphorylation profiles of many kinases and also increased secretion of IL-6 and IL-8 cytokines. Cisplatin 31-40 interleukin 6 Homo sapiens 132-136 26718326-5 2016 We noted that the purified nonameric peptide (AIGIDP) attenuated the phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-induced histamine release and the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6 in human mast cells (HMC-1 cells). Tetradecanoylphorbol Acetate 69-100 interleukin 6 Homo sapiens 291-295 26164553-8 2016 Depending on the environmental or human origin the structures differed in the length and degree of fatty acid acylation and impacted the IL-6 and TNF-alpha inflammatory responses tested. Fatty Acids 99-109 interleukin 6 Homo sapiens 137-141 26839875-5 2016 Fasting glucose positively correlated with hs-CRP, interleukin-6, tumor necrosis factor-alpha, oxidized low density lipoprotein (LDL) and malondialdehyde. Glucose 8-15 interleukin 6 Homo sapiens 51-93 26615369-9 2016 Aspirin challenge induced the release of uLTE4, IL-6 and increased the number of CD4(+)CD45RA(-)CD45RO(+) memory T-cells only in AERD patients but failed to reduce the levels of sCD40L as observed in non-AERD subjects. Aspirin 0-7 interleukin 6 Homo sapiens 48-52 26615369-10 2016 Further, IL-8 and sIL-5R-alpha levels directly correlated with the PD20ASA and the effects of aspirin on IL-6 and number of memory T-cells was more pronounced in subjects showing more strong reaction (bronchial and nasal). Aspirin 94-101 interleukin 6 Homo sapiens 105-109 26615369-12 2016 Systemic response to oral aspirin challenge was related to an increase in serum IL-6 and the number of circulating memory T-cells in AERD patients. Aspirin 26-33 interleukin 6 Homo sapiens 80-84 27050175-2 2016 It is based on evidence that a continuous long-term exposure to oral bacteremia and bacterial toxins induces inflammatory immune response after immune evasion releases growth factors such as FGF, EGF, TGF-Beta, free radicals such as ROS and NOS, cytokines such as TNFAlfa, IL-1 Beta, IL-6; and matrix metalloproteinase such as MMP-9. ros 233-236 interleukin 6 Homo sapiens 284-288 26263552-15 2016 After accounting for SDS, IL-6 concentrations in young women remained higher after both mental and physical stress. Sodium Dodecyl Sulfate 21-24 interleukin 6 Homo sapiens 26-30 25565094-7 2016 IL-6 was inversely related to birth weight adjusted for gestational age at delivery (r=-0.3382, p<0.001) and glucose levels at oral glucose test. Glucose 112-119 interleukin 6 Homo sapiens 0-4 26355467-10 2016 The low vitamin D group had higher baseline IL-6 levels (median, 4.4 [interquartile range, 2.0-5.7] versus 1.1 [0.8-1.7] pg/mL, P = 0.004) and lower interleukin-12 levels (0.3 [0.1-0.4] versus 0.5 [0.5-0.6] pg/mL, P = 0.006) compared with the normal vitamin D group. Vitamin D 8-17 interleukin 6 Homo sapiens 44-48 26549437-5 2016 Surprisingly, pimozide reduced the basal expression of phosphorylation STAT3 at tyrosine 705 and reversed the expression of phosphorylation of STAT3 induced by IL-6 addition, suggesting that pimozide can suppress cellular STAT3 activation. Pimozide 14-22 interleukin 6 Homo sapiens 160-164 26549437-5 2016 Surprisingly, pimozide reduced the basal expression of phosphorylation STAT3 at tyrosine 705 and reversed the expression of phosphorylation of STAT3 induced by IL-6 addition, suggesting that pimozide can suppress cellular STAT3 activation. Pimozide 191-199 interleukin 6 Homo sapiens 160-164 26718326-5 2016 We noted that the purified nonameric peptide (AIGIDP) attenuated the phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-induced histamine release and the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6 in human mast cells (HMC-1 cells). Calcium 106-113 interleukin 6 Homo sapiens 291-295 26439246-7 2016 A single dose of cisplatin (7.5 mg/kg) resulted in significant increase in serum creatinine, blood urea nitrogen, NF-kB, TNF-alpha and IL-6 levels along with decrease in albumin and IL-10 levels. Cisplatin 17-26 interleukin 6 Homo sapiens 135-139 26431069-9 2016 Administration of 10 muM PD98059 significantly decreased IL-6 levels in the AF-MPhi coculture, and decreased the levels of TNF alpha and IL-8 in both the AF-MPhi and NP-MPhi cocultures. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 25-32 interleukin 6 Homo sapiens 57-61 27487299-8 2016 IL-6 treatment increased NF-kappaB activity in human IMAs stretched with 3 g, and this effect was further blocked by stretch-activated channel (SAC) inhibitors (streptomycin or GdCl3) and SN50. Streptomycin 161-173 interleukin 6 Homo sapiens 0-4 27487299-8 2016 IL-6 treatment increased NF-kappaB activity in human IMAs stretched with 3 g, and this effect was further blocked by stretch-activated channel (SAC) inhibitors (streptomycin or GdCl3) and SN50. gadolinium chloride 177-182 interleukin 6 Homo sapiens 0-4 27487299-8 2016 IL-6 treatment increased NF-kappaB activity in human IMAs stretched with 3 g, and this effect was further blocked by stretch-activated channel (SAC) inhibitors (streptomycin or GdCl3) and SN50. SN50 188-192 interleukin 6 Homo sapiens 0-4 26536614-1 2016 OBJECTIVE: To evaluate the effect of N-benzyl-4-bromobenzamide (NBBA) on lipopolysaccharide (LPS)-induced IL-6 and prostaglandin E2 (PGE2) production in human gingival fibroblasts (HGFs). n-benzyl-4-bromobenzamide 37-62 interleukin 6 Homo sapiens 106-110 26536614-10 2016 The benzamide compound, NBBA, exhibited a potent anti-IL-6 activity with inhibition of 35.6 +- 0.5%, significantly different from in the LPS-induced HGFs (p < 0.001). benzamide 4-13 interleukin 6 Homo sapiens 54-58 26573554-7 2016 In human mast cells, sesamin reduced the stimulatory effects of phorbol 12-myristate 13-acetate and calcium ionophore A23187 on the production and secretion of pro-inflammatory cytokines, including tumor necrosis factor-alpha and interleukin-6. Tetradecanoylphorbol Acetate 64-95 interleukin 6 Homo sapiens 230-243 26573554-7 2016 In human mast cells, sesamin reduced the stimulatory effects of phorbol 12-myristate 13-acetate and calcium ionophore A23187 on the production and secretion of pro-inflammatory cytokines, including tumor necrosis factor-alpha and interleukin-6. Calcium 100-107 interleukin 6 Homo sapiens 230-243 26423306-8 2016 PHE/TYR was positively correlated with interleukin (IL)-1beta (r = 0.37, p = 0.011) and IL-6 (r = 0.33, p = 0.025). Tyrosine 4-7 interleukin 6 Homo sapiens 88-92 25798666-3 2016 The exposure of human glomerulus renal endothelial cells to cadmium promotes a polarized apical secretion of IL-6 and IL-8, two pivotal proinflammatory cytokines known to play a significant role in renal inflammation. Cadmium 60-67 interleukin 6 Homo sapiens 109-113 25798666-4 2016 Proinflammatory cytokine secretion by human renal glomerulus endothelial cells could be the result of cadmium-induced IL-6 secretion via an NF-kappaB-dependent pathway. Cadmium 102-109 interleukin 6 Homo sapiens 118-122 25798666-6 2016 The results of the current study reveal that mangiferin could prevent both cadmium-induced IL-6 and IL-8 secretion by human glomerulus endothelial cells and be used to prevent renal inflammation. Cadmium 75-82 interleukin 6 Homo sapiens 91-95 26989333-6 2016 In addition, Smac127 induces a significant inhibition of the secretion of IL-15 and IL-6, stimulation of pannus formation, and damage of bone and cartilage in RA. smac127 13-20 interleukin 6 Homo sapiens 84-88 26891593-2 2016 METHODS: Cells treated with curcumin-loaded BNNTs and stimulated with lipopolysaccharide were assessed for nitric oxide release and stimulation of IL-6 and TNF-alpha. Curcumin 28-36 interleukin 6 Homo sapiens 147-151 26705025-5 2016 High glucose also elevated IL-6 (1.8-fold), IL-1beta (1.9-fold), and TNF-alpha (1.6-fold) level, as well as induced cell apoptosis and NF-kappaB (6.1-fold) activation. Glucose 5-12 interleukin 6 Homo sapiens 27-31 26627016-3 2016 In CKD, interleukin-6 and hypersensitive C-reactive protein are known to be used for the evaluation of inflammation and serum levels increase with decreased creatinine clearance. Creatinine 157-167 interleukin 6 Homo sapiens 8-21 26808720-9 2016 (R)-(+)-limonene derivatives decreased IL-6 production from normal cells in media with or without LPS (30.2% and 13.9%, respectively), while (-)-alpha-pinene derivatives induced IL-6 (verbenone had the strongest effect, 60.2% and 29.1% above control, respectively). Limonene 0-16 interleukin 6 Homo sapiens 39-43 26854669-6 2016 Covariance analysis confirmed that differences in IL-1beta and IL-6 levels were determined by pharmacotherapy and fasting plasma glucose, whereas in IL-10 levels by the therapy only. Glucose 129-136 interleukin 6 Homo sapiens 63-67 26431803-6 2016 In controls, the rise in cortisol following the challenge was negatively correlated to the subsequent changes in IL-6 (r=-.461, p=.003), such that rise of cortisol immediately after stress predicts subsequently lower IL-6 levels. Hydrocortisone 25-33 interleukin 6 Homo sapiens 113-117 27458626-2 2016 Enhanced hepcidin production mainly stimulated by excess interleukin-6 levels is a key pathodgentic component of ACD (frequently known as anemia of inflammation) by causing the degradation of the transmembrane protein ferroportin, hepcidin impairs iron metabolism. Iron 248-252 interleukin 6 Homo sapiens 57-70 25715004-7 2015 The latanoprost-induced release of IL-6, IL-8, and MCP-1 was attenuated by inhibitors of MAPK (PD98059, SB203580, or JNK inhibitor II) or NF-kappaB (IkappaB kinase 2 inhibitor) signaling pathways. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 95-102 interleukin 6 Homo sapiens 35-39 26782552-0 2015 Sevoflurane downregulates interleukin-6 and interleukin-8 levels in patients after cardiopulmonary bypass surgery: a meta-analysis. Sevoflurane 0-11 interleukin 6 Homo sapiens 26-39 26782552-1 2015 This study aimed to investigate the effect of sevoflurane on serum levels of interleukin (IL)-6 and IL-8 in patients who underwent cardiopulmonary bypass (CPB). Sevoflurane 46-57 interleukin 6 Homo sapiens 77-95 26782552-2 2015 The strength of the association between sevoflurane treatment and serum level of IL-6 and IL-8 was determined in patients who underwent CPB by summary standard mean differences (SMDs); 95% confidence interval (CI) was used. Sevoflurane 40-51 interleukin 6 Homo sapiens 81-85 26782552-3 2015 In total, seven case-control studies showed decreased IL-6 and IL-8 levels in sevoflurane-treated patients than in controls (IL-6: SMD = 1.56, 95%CI: 0.95-2.17, P < 0.001; IL-8: SMD = 1.63, 95%CI: 0.30-2.96, P < 0.001, respectively). Sevoflurane 78-89 interleukin 6 Homo sapiens 54-58 26782552-3 2015 In total, seven case-control studies showed decreased IL-6 and IL-8 levels in sevoflurane-treated patients than in controls (IL-6: SMD = 1.56, 95%CI: 0.95-2.17, P < 0.001; IL-8: SMD = 1.63, 95%CI: 0.30-2.96, P < 0.001, respectively). Sevoflurane 78-89 interleukin 6 Homo sapiens 125-129 26782552-4 2015 Further, IL-6 and IL-8 levels were significantly higher in sevoflurane-treated patients than in sevoflurane-pretreated patients (IL-6 post vs pre: SMD = 2.17, 95%CI: 1.40-2.95, P < 0.001; IL-8 post vs pre: SMD = 4.01, 95%CI: 2.80-5.21, P < 0.001, respectively). Sevoflurane 59-70 interleukin 6 Homo sapiens 9-13 26782552-4 2015 Further, IL-6 and IL-8 levels were significantly higher in sevoflurane-treated patients than in sevoflurane-pretreated patients (IL-6 post vs pre: SMD = 2.17, 95%CI: 1.40-2.95, P < 0.001; IL-8 post vs pre: SMD = 4.01, 95%CI: 2.80-5.21, P < 0.001, respectively). Sevoflurane 59-70 interleukin 6 Homo sapiens 129-133 26782552-4 2015 Further, IL-6 and IL-8 levels were significantly higher in sevoflurane-treated patients than in sevoflurane-pretreated patients (IL-6 post vs pre: SMD = 2.17, 95%CI: 1.40-2.95, P < 0.001; IL-8 post vs pre: SMD = 4.01, 95%CI: 2.80-5.21, P < 0.001, respectively). Sevoflurane 96-107 interleukin 6 Homo sapiens 129-133 26782552-5 2015 CPB-stratified analysis showed significant decrease in IL-6 and IL-8 levels in sevoflurane-treated patients than in controls, irrespective of the time after CPB surgery (P < 0.05). Sevoflurane 79-90 interleukin 6 Homo sapiens 55-59 26782552-6 2015 Moreover, sevoflurane-pretreated patients under the <12-h subgroup showed decreased IL-6 levels (P = 0.698), while all other subgroups showed decreased IL-8 levels (P < 0.05). Sevoflurane 10-21 interleukin 6 Homo sapiens 87-91 26782552-7 2015 Further, subgroup analysis by different dose of sevoflurane showed decreased IL-6 and IL-8 levels in subgroups administered with a dose of <2 and >= 2% sevoflurane under the case vs control and pre- vs post-treatment of sevoflurane models. Sevoflurane 48-59 interleukin 6 Homo sapiens 77-81 26782552-7 2015 Further, subgroup analysis by different dose of sevoflurane showed decreased IL-6 and IL-8 levels in subgroups administered with a dose of <2 and >= 2% sevoflurane under the case vs control and pre- vs post-treatment of sevoflurane models. Sevoflurane 158-169 interleukin 6 Homo sapiens 77-81 26782552-7 2015 Further, subgroup analysis by different dose of sevoflurane showed decreased IL-6 and IL-8 levels in subgroups administered with a dose of <2 and >= 2% sevoflurane under the case vs control and pre- vs post-treatment of sevoflurane models. Sevoflurane 158-169 interleukin 6 Homo sapiens 77-81 26782552-8 2015 Serum IL-6 and IL-8 levels were significantly lower in sevoflurane-treated patients who underwent CPB, suggesting sevoflurane pretreatment to be more beneficial than post-treatment. Sevoflurane 55-66 interleukin 6 Homo sapiens 6-10 26782552-8 2015 Serum IL-6 and IL-8 levels were significantly lower in sevoflurane-treated patients who underwent CPB, suggesting sevoflurane pretreatment to be more beneficial than post-treatment. Sevoflurane 114-125 interleukin 6 Homo sapiens 6-10 26677330-11 2015 CONCLUSION: These results demonstrate that serum levels of interleukin-6, interleukin-8, and macrophage inflammatory protein-1beta as potential blood biomarkers could be utilized to identify the responsiveness of patients to serotonin and norepinephrine reuptake inhibitor like milnacipran, or to identify those patients who may experience AEs strong enough to warrant discontinuation of treatment. Serotonin 225-234 interleukin 6 Homo sapiens 59-72 26677330-11 2015 CONCLUSION: These results demonstrate that serum levels of interleukin-6, interleukin-8, and macrophage inflammatory protein-1beta as potential blood biomarkers could be utilized to identify the responsiveness of patients to serotonin and norepinephrine reuptake inhibitor like milnacipran, or to identify those patients who may experience AEs strong enough to warrant discontinuation of treatment. Norepinephrine 239-253 interleukin 6 Homo sapiens 59-72 26141422-7 2015 The GG genotype of the -179C/G polymorphism (IL6) was associated with higher glucose levels, while the GA and AA genotypes of the -1082A/G polymorphism (IL10), CT and TT genotypes of the -819A/T polymorphism (IL10), CA and AA genotypes of the -522A/G (IL10) polymorphism, and TA genotype of the +874T/A polymorphism (IFN-gamma) were associated with lower total cholesterol and triglycerides levels. Glucose 77-84 interleukin 6 Homo sapiens 45-48 26335627-10 2015 CONCLUSIONS: Twenty-four hours of controlled low carbohydrate intake resulted in higher baseline hepcidin levels and post-exercise IL-6 responses than a high carbohydrate intake. Carbohydrates 49-61 interleukin 6 Homo sapiens 131-135 26644840-0 2015 Effect of topical application of melatonin on serum levels of C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in patients with type 1 or type 2 diabetes and periodontal disease. Melatonin 33-42 interleukin 6 Homo sapiens 88-101 26644840-1 2015 BACKGROUND: The present clinical trial study was designed to assess the effect of topical application of melatonin on serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and C-reactive protein (CRP) in patients with diabetes and periodontal disease in comparison with healthy controls. Melatonin 105-114 interleukin 6 Homo sapiens 175-188 26644840-1 2015 BACKGROUND: The present clinical trial study was designed to assess the effect of topical application of melatonin on serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and C-reactive protein (CRP) in patients with diabetes and periodontal disease in comparison with healthy controls. Melatonin 105-114 interleukin 6 Homo sapiens 190-194 26644840-7 2015 Following topical melatonin application, there was a statistically significant decrease in the gingival index and pocket depth (P < 0.001) as well as a significant decrease in IL-6 and CRP serum levels (P < 0.001). Melatonin 18-27 interleukin 6 Homo sapiens 179-183 26644840-8 2015 Local melatonin application in patients with diabetes and periodontal disease resulted in a significant decrease in CRP and IL-6 serum levels as well as an improvement in the gingival index and pocket depth. Melatonin 6-15 interleukin 6 Homo sapiens 124-128 29227593-5 2016 Curcumin displayed the inhibitoryeffect on gene expression of AbetaPP, TNFalpha and IL6, which resulted in the decrease of the level of these twocytokines and Abeta40. Curcumin 0-8 interleukin 6 Homo sapiens 84-87 26641100-7 2015 ANCE-induced IL-6, IL-8, and MCP-1 release was inhibited by IL-1 receptor antagonist and by an IKK2 inhibitor (a blocker of NF-kappaB signaling) in a concentration-dependent manner, but was not affected by a pan-caspase inhibitor (Z-VAD-FMK). ance 0-4 interleukin 6 Homo sapiens 13-17 26396142-6 2015 Mechanistic studies have shown that calcitriol-active form of vitamin D-influences inflammatory processes involved in cancer progression, including the enzyme cyclooxygenase 2, the NF-kappaB pathway, and the expression of the cytokines TNFalpha, IL1beta, IL6, IL8, IL17, and TGFbeta1. Vitamin D 62-71 interleukin 6 Homo sapiens 255-258 26396259-11 2015 Moreover, cytosporone B, an NR4A1 agonist, completely reversed cholesterol-induced IL-6 (interleukin 6) and MCP-1 (monocyte chemoattractant protein 1) expression to below basal levels, and knockdown of NR4A1 expression by siRNA not only mimicked, but also exaggerated the effects of cholesterol on inflammatory biomarker up-regulation. Cholesterol 63-74 interleukin 6 Homo sapiens 83-87 26396259-11 2015 Moreover, cytosporone B, an NR4A1 agonist, completely reversed cholesterol-induced IL-6 (interleukin 6) and MCP-1 (monocyte chemoattractant protein 1) expression to below basal levels, and knockdown of NR4A1 expression by siRNA not only mimicked, but also exaggerated the effects of cholesterol on inflammatory biomarker up-regulation. Cholesterol 63-74 interleukin 6 Homo sapiens 89-102 26606434-8 2015 Calcium antagonists have been found to reduce extra cellular matrix production, induce procollagenase synthesis, and inhibit interleukin-6, vascular endothelial growth factor, and proliferation of fibroblasts. Calcium 0-7 interleukin 6 Homo sapiens 125-138 25994389-10 2015 The IL6 haplotypes were associated with total cholesterol, triglycerides, HDL and LDL subclasses after adjusting for confounders. Cholesterol 46-57 interleukin 6 Homo sapiens 4-7 25994389-10 2015 The IL6 haplotypes were associated with total cholesterol, triglycerides, HDL and LDL subclasses after adjusting for confounders. Triglycerides 59-72 interleukin 6 Homo sapiens 4-7 25970495-0 2015 Rhabdomyolysis After Out-of-Water Exercise in an Elite Adolescent Water Polo Player Carrying the IL-6 174C Allele Single-Nucleotide Polymorphism. Water 28-33 interleukin 6 Homo sapiens 97-101 26769828-9 2015 In the riboflavin-supplemented group, LPS-stimulated macrophages showed lower mortality accompanied by higher Hsp72 expression, reduction of Toll-like receptor 4 (TLR4) and TNF-alpha, and elevation of NO, IL-6, and IL-10. Riboflavin 7-17 interleukin 6 Homo sapiens 205-209 25970495-1 2015 We present an adolescent elite water polo player who despite a genetic predisposition to develop exercise-induced severe muscle damage due to carrying the IL-6 174C allele single-nucleotide polymorphism, developed acute rhabdomyolysis only after a vigorous out-of-water training, suggesting that water polo training may be more suitable for genetically predisposed athletes. Water 31-36 interleukin 6 Homo sapiens 155-159 26866011-20 2015 Interleukin -6 correlated negatively (significantly) with MAC; MAMA; serum albumin, cholesterol, and transferrin. Cholesterol 84-95 interleukin 6 Homo sapiens 0-14 26270575-8 2015 ARA had potent anti-inflammatory effects with lower IL-8 and IL-6 (protein and mRNA) in fetal H4 but not in NEC-IEC or adult IEC. Arachidonic Acid 0-3 interleukin 6 Homo sapiens 61-65 26269412-12 2015 Pazopanib in a dose of 30 mg/kg improved liver function, reduced fibrosis (1.48%), and decreased significantly (P < 0.01) liver expression of malondialdehyde, TGF-beta1, IL-6, TNF-alpha, Col1A1, TIMP-1, alpha-SMA, MMP-2, PDGF receptor-beta, and VEGF receptor-1. pazopanib 0-9 interleukin 6 Homo sapiens 173-177 26402162-8 2015 RESULTS: IL6 induced ROS and carbonyl content in all 3 cell lines (all P<0.001). ros 21-24 interleukin 6 Homo sapiens 9-12 26402162-10 2015 Selenite decreases the IL6-induced ROS and carbonyl content, while enhances Gpx and Trx activities. ros 35-38 interleukin 6 Homo sapiens 23-26 26319615-7 2015 MAIN OUTCOME MEASURE: Change in TNF-alpha and IL-6 levels in collected media after vitamin D treatment (ELISA). Vitamin D 83-92 interleukin 6 Homo sapiens 46-50 26572585-4 2015 EC overexpression of mutant ITGB4 with specific tyrosines mutated to phenylalanine (Y1440, Y1526 Y1640, or Y1422) resulted in significantly attenuated CS-induced cytokine expression (IL6, IL-8, MCP-1, and RANTES). Tyrosine 48-57 interleukin 6 Homo sapiens 183-186 26581448-10 2015 High-dose corticosteroid and cyclosporine therapy led to a drastic improvement of MAS with decreased IL-6 levels. Cyclosporine 29-41 interleukin 6 Homo sapiens 101-105 26410779-5 2015 The analysis of pro-inflammatory cytokines release by ELISA revealed that resveratrol, lipoic acid melatonin and Co-Q10 inhibited the BBB endothelial release of pro-inflammatory cytokines IL-6 and IL-8, reduced (not Co-Q10) CSE-induced up-regulation of Platelet Cell Adhesion Molecule-1 (PECAM-1), Vascular Cell Adhesion Molecule-1 (VCAM-1) & E-selectin and inhibited monocytes-endothelial cell adhesion. Resveratrol 74-85 interleukin 6 Homo sapiens 188-192 26410779-5 2015 The analysis of pro-inflammatory cytokines release by ELISA revealed that resveratrol, lipoic acid melatonin and Co-Q10 inhibited the BBB endothelial release of pro-inflammatory cytokines IL-6 and IL-8, reduced (not Co-Q10) CSE-induced up-regulation of Platelet Cell Adhesion Molecule-1 (PECAM-1), Vascular Cell Adhesion Molecule-1 (VCAM-1) & E-selectin and inhibited monocytes-endothelial cell adhesion. coenzyme Q10 113-119 interleukin 6 Homo sapiens 188-192 26410779-5 2015 The analysis of pro-inflammatory cytokines release by ELISA revealed that resveratrol, lipoic acid melatonin and Co-Q10 inhibited the BBB endothelial release of pro-inflammatory cytokines IL-6 and IL-8, reduced (not Co-Q10) CSE-induced up-regulation of Platelet Cell Adhesion Molecule-1 (PECAM-1), Vascular Cell Adhesion Molecule-1 (VCAM-1) & E-selectin and inhibited monocytes-endothelial cell adhesion. Adenosine Monophosphate 342-345 interleukin 6 Homo sapiens 188-192 26635827-8 2015 Heat stimulates HSF activity directly, but also indirectly via ROS. Reactive Oxygen Species 63-66 interleukin 6 Homo sapiens 16-19 26885173-9 2015 RESULTS: Compared with those in normal glucose condition, IL-6 and IL-8 expression were increased in high glucose condition. Glucose 39-46 interleukin 6 Homo sapiens 58-62 26224075-7 2015 In hypertensive patients, ghrelin decreased venous levels of malondialdehyde, lipoperoxide, and interleukin-6, and concomitantly increased endogenous antioxidant capacity. Ghrelin 26-33 interleukin 6 Homo sapiens 96-109 26169021-6 2015 RESULTS: We found that the IL-6 -174C/G polymorphism might be associated with decreased risk of TB (C vs. G: OR=0.77, 95% CI=0.64-0.91; CG vs. GG: OR=0.72, 95% CI=0.57-0.90; CC+CG vs. GG: OR=0.71, 95% CI=0.57-0.88). Carbon 36-37 interleukin 6 Homo sapiens 27-31 26885173-9 2015 RESULTS: Compared with those in normal glucose condition, IL-6 and IL-8 expression were increased in high glucose condition. Glucose 106-113 interleukin 6 Homo sapiens 58-62 26296578-8 2015 Resveratrol exerted a high, dose-dependent, antiviral activity against HRV-16 replication and reduced virus-induced secretion of IL-6, IL-8 and RANTES to levels similar to that of uninfected nasal epithelia. Resveratrol 0-11 interleukin 6 Homo sapiens 129-133 26555695-6 2015 Using a combination of molecular design, phage-display, and medicinal chemistry, disulfide-rich peptides (DRPs) directed against IL-6 were developed with low nanomolar potency in inhibiting IL-6-induced pSTAT3 in U937 monocytic cells. Disulfides 81-90 interleukin 6 Homo sapiens 129-133 26555695-6 2015 Using a combination of molecular design, phage-display, and medicinal chemistry, disulfide-rich peptides (DRPs) directed against IL-6 were developed with low nanomolar potency in inhibiting IL-6-induced pSTAT3 in U937 monocytic cells. Disulfides 81-90 interleukin 6 Homo sapiens 190-194 26531309-9 2015 However, PSA-TMC-ODN and PSA-TMC-ODN-MTX resulted in significant decreases in the inflammatory mediators IL-6 and IL-8 in both cell models. psa-tmc-odn-mtx 25-40 interleukin 6 Homo sapiens 105-109 26343941-7 2015 The multifactorial ATP deficit also provides a plausible basis for the cardiomyopathy in patients with propionic acidemia, and other diseases.Additionally, systemic inflammation concomitant to the toxic state might explain our findings of enhanced IL-6, STAT3 and HIF-1alpha, associated with an increase of mitophagic BNIP3 and PINK proteins, which may further increase mitophagy. Adenosine Triphosphate 19-22 interleukin 6 Homo sapiens 248-252 26320144-10 2015 In addition, metformin reduced glucose, follicle-stimulating hormone, IL6 and TNFalpha levels and increased dehydroepiandrosterone sulfate levels. Metformin 13-22 interleukin 6 Homo sapiens 70-73 25869324-3 2015 RESULTS: IL-6 was the only biomarker with significant within-group change: 0.13 log10 pg/mL mean reduction among ibuprofen-treated subjects (p=0.04); and no change in the control group. Ibuprofen 113-122 interleukin 6 Homo sapiens 9-13 26122280-6 2015 In addition, ATP administration activated microglia, induced the release of the inflammatory mediators such as cyclooxygenase-2, tumor necrosis factor alpha and interleukin 6, and promoted neuronal apoptosis. Adenosine Triphosphate 13-16 interleukin 6 Homo sapiens 161-174 25967155-6 2015 Among persons with cardiac diseases, muscle strength in the lower tertile compared to the upper tertile was significantly associated with increased odds of having elevated IL-6 levels (OR 3.53, 95 % CI 1.18-10.50, p = 0.024) after controlling for age, gender, body fat, alcohol intake, smoking status, diseases, medications and physical activity, whereas the association between muscle strength and hs-CRP remained borderline significant (OR 2.80, 95 % CI 0.85-9.24, p = 0.092). Alcohols 270-277 interleukin 6 Homo sapiens 172-176 26172313-6 2015 NO-np significantly suppressed IL-1beta, tumor necrosis factor-alpha (TNF-alpha), IL-8, and IL-6 from human monocytes, and IL-8 and IL-6 from human keratinocytes, respectively. Neptunium 3-5 interleukin 6 Homo sapiens 92-96 26172313-6 2015 NO-np significantly suppressed IL-1beta, tumor necrosis factor-alpha (TNF-alpha), IL-8, and IL-6 from human monocytes, and IL-8 and IL-6 from human keratinocytes, respectively. Neptunium 3-5 interleukin 6 Homo sapiens 132-136 26338965-9 2015 Interestingly, treatment of active breast stromal fibroblasts with curcumin increased the level of the p16(INK4A) coding CDKN2A mRNA and miR-146b-5p and suppressed IL-6, which confirms the repressive effect of these two tumor suppressor molecules on IL-6, and shows the possible "normalization" of cancer-related active fibroblasts. Curcumin 67-75 interleukin 6 Homo sapiens 164-168 26141671-6 2015 In addition, treatment with metformin significantly reduced the expression of IL-6 and TNF-alpha at the messenger RNA level and attenuated nuclear factor kappa B (NF-kappaB) DNA binding activity in MNCs. Metformin 28-37 interleukin 6 Homo sapiens 78-82 26193055-4 2015 Erdosteine significantly suppressed the production of reactive nitrogen/oxygen species and pro-inflammatory cytokines such as tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-6 in cisplatin-treated cells. Cisplatin 191-200 interleukin 6 Homo sapiens 183-187 26497059-11 2015 Furthermore, we found elevated plasma concentrations of S-100beta protein, TNF-alpha and IL-6 in those receiving sevoflurane anesthesia. Sevoflurane 113-124 interleukin 6 Homo sapiens 89-93 26494971-7 2015 The decreased levels of IL-6/-8 observed throughout long-term vaccination were associated with WT1-specific DTH reactions and long-term OS. Osmium 136-138 interleukin 6 Homo sapiens 24-28 26474621-3 2015 Interleukin-6 (IL-6) expression was investigated by real-time PCR after U937 cells were treated with nicotine, P.g-LPS and their combination. Nicotine 101-109 interleukin 6 Homo sapiens 0-13 26474621-7 2015 However, the ability of P.g-LPS induced IL-6 expression was inhibited by 100 mumol/L nicotine in U937 cells. Nicotine 85-93 interleukin 6 Homo sapiens 40-44 26446923-9 2015 In comparison to the explants treated only with LPS, pre-treatment with 0.01-1.0 muM progesterone significantly blunted (73, 56, 56, 75, 25, 48 %) the secretion of TNF-alpha, IL-1beta, IL-6, IL-8, MIP-1alpha, IL-10, respectively. Progesterone 85-97 interleukin 6 Homo sapiens 185-189 26338965-9 2015 Interestingly, treatment of active breast stromal fibroblasts with curcumin increased the level of the p16(INK4A) coding CDKN2A mRNA and miR-146b-5p and suppressed IL-6, which confirms the repressive effect of these two tumor suppressor molecules on IL-6, and shows the possible "normalization" of cancer-related active fibroblasts. Curcumin 67-75 interleukin 6 Homo sapiens 250-254 25750008-11 2015 Compared with the control group, the hydrogen group had a statistically significantly lower expression of IL-1beta (P = 0.0317), IL-6 (P = 0.0159), IL-8 (P = 0.0195) and TNF-alpha (P = 0.0159). Hydrogen 37-45 interleukin 6 Homo sapiens 129-133 25781052-7 2015 Data also revealed a reduction in MUC5AC, IL-6, and IL-8 expression levels in MAG-DHA-treated shCFTR cells stimulated, or not, with LPS. dehydroacetic acid 82-85 interleukin 6 Homo sapiens 42-46 25986861-1 2015 Oncostatin M (OSM), a cytokine in the interleukin-6 (IL-6) family, has been proposed to play a protective role in the central nervous system, such as attenuation of excitotoxicity induced by N-methyl-D-aspartate (NMDA) and glutamate. Glutamic Acid 223-232 interleukin 6 Homo sapiens 53-57 25050518-6 2015 RESULTS: Serum concentrations of IL-4 (p=0.001), IL-6 (p=0.006) and hs-CRP (p=0.004) were significantly reduced in the curcuminoid group whilst serum levels of TNF-alpha and TGF-beta and mean ESR remained unaltered by the end of trial (p>0.05). curcuminoid 119-130 interleukin 6 Homo sapiens 49-53 26084589-0 2015 Timing of post-exercise carbohydrate ingestion: influence on IL-6 and hepcidin responses. Carbohydrates 24-36 interleukin 6 Homo sapiens 61-65 26084589-1 2015 PURPOSE: Carbohydrate ingestion prior and during exercise attenuates exercise-induced interleukin-6. Carbohydrates 9-21 interleukin 6 Homo sapiens 86-99 26445552-12 2015 IL-6 -174G/C gene polymorphism is associated with a significant morphine equivalent daily dose (IL-6 GG, 69.61; GC, 73.17; CC, 181.67; P=0.004). Morphine 64-72 interleukin 6 Homo sapiens 0-4 26313152-0 2015 IL-6 signaling contributes to cisplatin resistance in non-small cell lung cancer via the up-regulation of anti-apoptotic and DNA repair associated molecules. Cisplatin 30-39 interleukin 6 Homo sapiens 0-4 26313152-2 2015 The potential implication of IL-6 signaling in the cisplatin resistance of NSCLC was explored by testing whether NSCLC cells with different levels of intracellular IL-6 show different responses to the cytotoxic treatment of cisplatin. Cisplatin 51-60 interleukin 6 Homo sapiens 29-33 26313152-3 2015 When the cisplatin cytotoxicity of the IL-6 knocked down human NSCLC cells (A549IL-6si and H157IL-6si) were compared with their corresponding scramble control cells (A549sc and H157sc), higher cisplatin cytotoxicity was found in IL-6 si cells than sc cells. Cisplatin 9-18 interleukin 6 Homo sapiens 39-43 26313152-10 2015 These results provide potential for combining cisplatin and inhibitors of IL-6 signaling or its downstream signaling pathway as a future therapeutic approach in preventing development of cisplatin resistant NSCLC tumors. Cisplatin 187-196 interleukin 6 Homo sapiens 74-78 25991069-6 2015 We further observed that, relative to unsheared cells, HBMvECs presheared for 24 hours exhibited significantly reduced reactive oxygen species production and barrier permeabilization in response to either TNF-alpha or IL-6 treatment. Reactive Oxygen Species 119-142 interleukin 6 Homo sapiens 218-222 26424054-0 2015 MiR-125a-5p Decreases the Sensitivity of Treg cells Toward IL-6-Mediated Conversion by Inhibiting IL-6R and STAT3 Expression. mir-125a-5p 0-11 interleukin 6 Homo sapiens 59-63 26758116-11 2015 (3) In steroid group, IL-2 and IL-8 in BALF of patient whose fever disappeared after steroid therapy were both significantly lower than that of patients who still had fever (t=2.771, 2.054, P=0.010, 0.049) , but no significant difference was found between the two groups in BALF IL-1 beta, IL-4, IL-6, IL-10, IFN-gamma levels (P>0.05). Steroids 7-14 interleukin 6 Homo sapiens 296-300 26445552-12 2015 IL-6 -174G/C gene polymorphism is associated with a significant morphine equivalent daily dose (IL-6 GG, 69.61; GC, 73.17; CC, 181.67; P=0.004). Morphine 64-72 interleukin 6 Homo sapiens 96-100 26384335-5 2015 In parallel to SOCS3 expression, IL-6 induced tyrosine phosphorylation of signal transducer and activator of transcription 3 (STAT3) in NS-1 cells. Tyrosine 46-54 interleukin 6 Homo sapiens 33-37 26384335-6 2015 Lentiviral delivery of short hairpin RNA (shSOCS3) (Lenti-shSOCS3) to decrease SOCS3 expression into NS-1 cells enhanced IL-6-induced tyrosine phosphorylation of STAT3 (P-STAT3 Tyr705) and promoted neurite outgrowth. Tyrosine 134-142 interleukin 6 Homo sapiens 121-125 25894228-6 2015 Here, we investigated if APS attenuates IL-1beta- or TNF-alpha-mediated IL-6 and IL-8 expression in SZ95 sebocytes, whereas TNF-alpha was used as control. aps 25-28 interleukin 6 Homo sapiens 72-76 26333527-7 2015 IL-6, IL-8, IL-1beta and TNF-alpha concentration in NBL showed inverse correlation coefficients with the peroxidation products of fatty acids. Fatty Acids 130-141 interleukin 6 Homo sapiens 0-4 25894228-11 2015 Concomitant treatment of SZ95 sebocytes with APS attenuated the effect of IL-1beta and TNF-alpha on IL-6 and IL-8 gene expression as well as on IL-1beta-mediated NF-kappaB signaling. aps 45-48 interleukin 6 Homo sapiens 100-104 26359865-8 2015 IL-6 levels also were elevated among APTB compared to HHC and HC, and a significant difference was observed between APTB and HHC at P<0.0001; APTB & HC at P< 0.04; HHC & HC at P< 0.01. Adenosine Monophosphate 151-154 interleukin 6 Homo sapiens 0-4 26359865-8 2015 IL-6 levels also were elevated among APTB compared to HHC and HC, and a significant difference was observed between APTB and HHC at P<0.0001; APTB & HC at P< 0.04; HHC & HC at P< 0.01. Adenosine Monophosphate 179-182 interleukin 6 Homo sapiens 0-4 25641413-9 2015 LAS compounds decreased the viability of HUVECs and promoted the production of IL-6 and TNF-alpha. las compounds 0-13 interleukin 6 Homo sapiens 79-83 26188623-0 2015 Vitamin D supplementation up-regulates IL-6 and IL-17A gene expression in multiple sclerosis patients. Vitamin D 0-9 interleukin 6 Homo sapiens 39-43 26049028-4 2015 PF significantly down-regulated the production of interleukin (IL)-1beta and IL-6 from pSS PBMCs, and significantly inhibited ATP-induced expression of P2X7R, that might contribute to reduced IL-1beta and IL-6. Adenosine Triphosphate 126-129 interleukin 6 Homo sapiens 205-209 26049028-8 2015 We show for the first time that PF-mediated reduction of IL-1beta and IL-6 was due in part to the reduced expression and activation of the ATP sensor P2X7R on pSS PBMCs, indicating that PF might be useful for the management of pSS via down-regulating P2X7R expression. Adenosine Triphosphate 139-142 interleukin 6 Homo sapiens 70-74 26093270-2 2015 Results revealed that capsaicin inhibits LPS-induced IL-1beta, IL-6 and TNF-alpha production in a time- and dose-dependent manner. Capsaicin 22-31 interleukin 6 Homo sapiens 63-67 26093270-4 2015 Inhibition of LXRalpha activation by siRNA diminished the inhibitory action of capsaicin on LPS-induced IL-1beta, IL-6 and TNF-alpha production. Capsaicin 79-88 interleukin 6 Homo sapiens 114-118 26188623-3 2015 The aim of this study was to investigate the vitamin D effects on the expression level of IL-6 and IL-17A in peripheral blood mononuclear cells (PBMCs) of multiple sclerosis (MS) patients. Vitamin D 45-54 interleukin 6 Homo sapiens 90-94 26188623-5 2015 Significant up-regulation of IL-6 and IL-17A gene expression was shown under vitamin D treatment. Vitamin D 77-86 interleukin 6 Homo sapiens 29-33 26189947-8 2015 mRNA expression levels of IL-6, cyclooxygenase-2, and iNOS were elevated in donor chondrocyte cultures treated with rhCCL20. rhccl20 116-123 interleukin 6 Homo sapiens 26-30 25927423-2 2015 The current study determines gingival crevicular fluid (GCF) levels of fibrosis-related IL-6-type cytokines in cyclosporine A (CsA)-induced gingival overgrowth (GO). Cyclosporine 127-130 interleukin 6 Homo sapiens 88-92 26136104-6 2015 The results revealed that treatment with YCG063 significantly inhibited the levels of IL-6, IL-8, MCP-1 and ICAM-1 in the PA-LPS-stimulated ARPE-19 cells. YCG 063 41-47 interleukin 6 Homo sapiens 86-90 25927423-2 2015 The current study determines gingival crevicular fluid (GCF) levels of fibrosis-related IL-6-type cytokines in cyclosporine A (CsA)-induced gingival overgrowth (GO). Cyclosporine 111-125 interleukin 6 Homo sapiens 88-92 26690867-0 2015 Doxorubicin-Hyaluronan Conjugated Super-Paramagnetic Iron Oxide Nanoparticles (DOX-HA-SPION) Enhanced Cytoplasmic Uptake of Doxorubicin and Modulated Apoptosis, IL-6 Release and NF-kappaB Activity in Human MDA-MB-231 Breast Cancer Cells. Doxorubicin 0-11 interleukin 6 Homo sapiens 161-165 26690867-8 2015 DOX-HA-SPION enhanced apoptosis and significantly down regulated both pro-inflammatory mediators IL-6 and NF-kappaB in comparison to DOX alone. Doxorubicin 0-3 interleukin 6 Homo sapiens 97-101 25927423-12 2015 CONCLUSIONS: IL-6 and OSM increases in GCF as a result of CsA usage or an immunosuppressed state irrespective of the severity of inflammation and the presence of GO. Cyclosporine 58-61 interleukin 6 Homo sapiens 13-17 26190660-11 2015 Increased interleukin (IL)-6 concentrations were associated with increased glucose (estimate [EST]: 0.55 (+-0.13) mmol/L; P < .001) and insulin (EST: 1.14 (+-0.12) mumol/L; P < .001) in linear regression adjusted for repeated measures. Glucose 75-82 interleukin 6 Homo sapiens 10-28 26426613-10 2015 Levels of IL-6, IL-1beta, and IL-8 detected in NPA from RSV single and associated to HRV were significantly higher than HRV infected and positively associated with days requiring O2.Levels of IL-6, IL-1beta, and IL-8 detected in NPA from patients infected with RSV only or with both RSV and HRV are increased, and any of those 3 cytokines may have a predictive value for the number of days with need of supplemental oxygen. Oxygen 179-181 interleukin 6 Homo sapiens 10-14 26330753-5 2015 This study was carried out to assess how dexmedetomidine modulates histamine-induced Ca(2+) signaling and regulates the expression of pro-inflammatory cytokine genes encoding interleukin (IL)-6 and -8. Histamine 67-76 interleukin 6 Homo sapiens 175-200 26330753-9 2015 Histamine stimulated IL-6 mRNA expression not IL-8 mRNA within 2 hrs, however this effect was attenuated by dexmedetomidine. Histamine 0-9 interleukin 6 Homo sapiens 21-25 26330753-10 2015 Collectively, these findings suggest that dexmedetomidine modulates histamine-induced Ca(2+) signaling and IL-6 expression and will be useful for understanding the antagonistic properties of dexmedetomidine on histamine-induced signaling beyond its sedative effect. Histamine 210-219 interleukin 6 Homo sapiens 107-111 26269716-6 2015 We found that IL6, TNF, CXCL8, IL1B and ERK1/2 were the top genes in terms of the number of connections in platinum-induced neuropathy and TP53, MYC, PARP1, P38 MAPK and TNF for combined taxane-platinum-induced neuropathy. Platinum 107-115 interleukin 6 Homo sapiens 14-17 26334856-5 2015 RESULTS: A comparison of patients between both groups revealed significantly high levels of IL-6 in the control group at T2, T3, and T4 with respect to T1 (T2: P &lt; .001; T3: P &lt; .001; T4: P &lt; .001). Adenosine Monophosphate 163-166 interleukin 6 Homo sapiens 92-96 26334856-5 2015 RESULTS: A comparison of patients between both groups revealed significantly high levels of IL-6 in the control group at T2, T3, and T4 with respect to T1 (T2: P &lt; .001; T3: P &lt; .001; T4: P &lt; .001). Adenosine Monophosphate 184-187 interleukin 6 Homo sapiens 92-96 26334856-5 2015 RESULTS: A comparison of patients between both groups revealed significantly high levels of IL-6 in the control group at T2, T3, and T4 with respect to T1 (T2: P &lt; .001; T3: P &lt; .001; T4: P &lt; .001). Adenosine Monophosphate 184-187 interleukin 6 Homo sapiens 92-96 26160960-6 2015 The cultivation in resveratrol preserved the CB-HSC phenotype in vitro most efficiently and was ~2 times more potent than commonly used cytokine conditions (including stem cell factor, thrombopoietin, Fms-related tyrosine kinase 3 ligand, interleukin-6) and the recently established serum-free culture, including IGFBP2 and angiopoietin-like 5. Resveratrol 19-30 interleukin 6 Homo sapiens 239-252 26601233-4 2015 Using fractal circuit sensors (FraCS), three-dimensional metal structures with large surface areas, we were able to rapidly (<20 min) and reproducibly quantify small differences in the expression of interleukin-6 (IL-6), IL-10, and ATP11B mRNA in donor lung biopsies. Metals 57-62 interleukin 6 Homo sapiens 202-215 26269716-6 2015 We found that IL6, TNF, CXCL8, IL1B and ERK1/2 were the top genes in terms of the number of connections in platinum-induced neuropathy and TP53, MYC, PARP1, P38 MAPK and TNF for combined taxane-platinum-induced neuropathy. taxane 187-193 interleukin 6 Homo sapiens 14-17 26269716-6 2015 We found that IL6, TNF, CXCL8, IL1B and ERK1/2 were the top genes in terms of the number of connections in platinum-induced neuropathy and TP53, MYC, PARP1, P38 MAPK and TNF for combined taxane-platinum-induced neuropathy. Platinum 194-202 interleukin 6 Homo sapiens 14-17 26187318-4 2015 IL-6 and CRP also influenced the extent of the arithmetic bias when calculating the GFR using the chronic kidney disease epidemiology (CKD-EPI) formula with just serum creatinine. Creatinine 168-178 interleukin 6 Homo sapiens 0-4 25361222-7 2015 RESULTS: The ghrelin group had a shorter SIRS duration and lower CRP and IL-6 levels than did the placebo group. Ghrelin 13-20 interleukin 6 Homo sapiens 73-77 26190093-4 2015 Resveratrol can both decrease the secretion of proinflammatory cytokines (e.g., IL-6, IL-8, and TNF-alpha) and increase the production of anti-inflammatory cytokines; it also decreases the expression of adhesion proteins (e.g., ICAM-1) and leukocyte chemoattractants (e.g., MCP-1). Resveratrol 0-11 interleukin 6 Homo sapiens 80-84 26179154-4 2015 In early (first-third) passages, IL-6 and IL-8 concentration was higher at 20% O2 and in late (8th-12th) passages under 5% O2. Oxygen 79-81 interleukin 6 Homo sapiens 33-37 25683698-9 2015 GR sensitivity was evaluated in vitro in isolated peripheral blood mononuclear cells using the dexamethasone inhibition of lipopolysaccharide-stimulated IL-6 levels. Dexamethasone 95-108 interleukin 6 Homo sapiens 153-157 26280503-1 2015 BACKGROUND: It has been known for decades that many cytokines, such as IL-2, IL-6, and IL-12, bind to heparin. Heparin 102-109 interleukin 6 Homo sapiens 77-81 26179154-4 2015 In early (first-third) passages, IL-6 and IL-8 concentration was higher at 20% O2 and in late (8th-12th) passages under 5% O2. Oxygen 123-125 interleukin 6 Homo sapiens 33-37 26033364-0 2015 MicroRNA-101 overexpression by IL-6 and TNF-alpha inhibits cholesterol efflux by suppressing ATP-binding cassette transporter A1 expression. Cholesterol 59-70 interleukin 6 Homo sapiens 31-35 25795285-9 2015 Curcumin increased interleukin-6 concentrations at 0-h (31 %; +-29 %) and 48-h (32 %; +-29 %) relative to baseline, but decreased IL-6 at 24-h relative to post-exercise (-20 %; +-18 %). Curcumin 0-8 interleukin 6 Homo sapiens 19-32 25795285-9 2015 Curcumin increased interleukin-6 concentrations at 0-h (31 %; +-29 %) and 48-h (32 %; +-29 %) relative to baseline, but decreased IL-6 at 24-h relative to post-exercise (-20 %; +-18 %). Curcumin 0-8 interleukin 6 Homo sapiens 130-134 25411996-9 2015 Instead, plasma IL-6 and serum CRP concentrations are more effective in predicting the severity of the clinical course in the early phase of LVAD therapy. lvad 141-145 interleukin 6 Homo sapiens 16-20 25869726-7 2015 Multiple logistic regression analysis showed that serum melatonin levels were associated with 30-day mortality (odds ratio, 1.022; 95% confidence interval, 1.001-1.043; P = .04), controlling for serum tumor necrosis factor-alpha levels, serum interleukin 6 levels and age. Melatonin 56-65 interleukin 6 Homo sapiens 243-256 26305534-7 2015 The addition of NAC markedly reduced the high glucose-induced ROS activation, Annexin-PI-positive cells, and levels of cleaved caspase-3, BAX, IL-6, and TNF-alpha. Acetylcysteine 16-19 interleukin 6 Homo sapiens 143-147 25869726-8 2015 Serum melatonin levels were positively associated with serum levels of malondialdehyde as biomarker of oxidative stress, interleukin-6 and lactate, and with SOFA score. Melatonin 6-15 interleukin 6 Homo sapiens 121-134 25954992-0 2015 Pre- or post-treatment with ethanol and ethyl pyruvate results in distinct anti-inflammatory responses of human lung epithelial cells triggered by interleukin-6. Ethanol 28-35 interleukin 6 Homo sapiens 147-160 25616404-8 2015 The Kyn/Trp ratio was positively associated with CD8(+) T-cell activation and levels of inflammatory cytokines (interleukin 6, interferon gamma-inducible protein 10, interleukin 18, and tumor necrosis factor alpha) and negatively associated with dendritic cell frequencies at baseline and in untreated patients. Tryptophan 8-11 interleukin 6 Homo sapiens 112-164 25822580-4 2015 Co-stimulation with IFN-gamma and the TLR3 ligand poly (I:C) synergistically increased the expression of IFN-beta, IL-6, IL-8, and human beta-defensin-2 in NHEKs compared with poly (I:C) or IFN-gamma alone. Carbon 0-1 interleukin 6 Homo sapiens 115-119 26006043-0 2015 Suppression of methylmercury-induced IL-6 and MCP-1 expressions by N-acetylcysteine in U-87MG human astrocytoma cells. Acetylcysteine 67-83 interleukin 6 Homo sapiens 37-41 26006043-7 2015 MeHg-induced expression of MCP-1 and IL-6 mRNA was reduced by 10-20% in the presence of 5mM NAC (co-treatment experiment) compared to cells treated with MeHg only. Acetylcysteine 92-95 interleukin 6 Homo sapiens 37-41 26006043-8 2015 Pre-treatment of cells with 0.5 or 5mM NAC at 0.5 or 1h and its subsequent washout before MeHg addition suppressed MCP-1 and IL-6 cytokine expressions. Acetylcysteine 39-42 interleukin 6 Homo sapiens 125-129 26006043-8 2015 Pre-treatment of cells with 0.5 or 5mM NAC at 0.5 or 1h and its subsequent washout before MeHg addition suppressed MCP-1 and IL-6 cytokine expressions. Hydrogen 53-55 interleukin 6 Homo sapiens 125-129 25954992-8 2015 Treatment of the A549 cells with either EtOH or EtP significantly reduced the IL-6-induced release of IL-8. Ethanol 40-44 interleukin 6 Homo sapiens 78-82 25954992-10 2015 Similar data was revealed regarding the IL-6-induced neutrophil adhesion to the treated A549 cells, in which pre- and post-treatment with EtOH or EtP decreased the adhesion capacity, however, the results were dependent on the duration of incubation. Ethanol 138-142 interleukin 6 Homo sapiens 40-44 26134310-6 2015 Our results demonstrated that PA dose-dependently inhibited LPS-induced TNF-alpha, IL-6, IL-1beta, and PGE2 production. protocatechuic acid 30-32 interleukin 6 Homo sapiens 83-87 33434968-5 2015 The in vitro and in vivo anti-inflammatory evaluation was performed and it has been confirmed that these nitrogen-rich surfaces could inhibit the activation of macrophages by down-regulation of the pro-inflammatory cytokines TNF-alpha and IL-6, and exhibit acceptable tissue-compatibility. Nitrogen 105-113 interleukin 6 Homo sapiens 239-243 26166037-0 2015 Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells. Gefitinib 93-102 interleukin 6 Homo sapiens 59-63 26166037-9 2015 HHT reversiblely inhibited IL-6-induced STAT3 Tyrosine 705 phosphorylation and reduced anti-apoptotic proteins expression. Tyrosine 46-54 interleukin 6 Homo sapiens 27-31 26185605-5 2015 Some of the suggested pathways are via transcription modulator of hepcidin (STAT3); ferroportin 1 expression on the cells involved in iron transport; transmembrane protease 6 enzyme; and pro-inflammatory cytokines, interleukin (IL)-1, IL-6, tumor necrosis factor-alpha and IL-10. Iron 134-138 interleukin 6 Homo sapiens 235-239 25626738-9 2015 Lower levels of MCP-1 and IL-8 (P < 0.001) and higher levels of IL-6 and MMP-9 (P = 0.003) were found in the sevoflurane group, compared with the TIVA group 30 min post-operatively. Sevoflurane 112-123 interleukin 6 Homo sapiens 67-71 26148005-10 2015 Our data suggests that DEP-induced intracellular ROS and release of the pro-inflammatory cytokines TNF- alpha and IL-6, which would contribute to VEGF-A secretion and disrupt cell-cell borders and increase vasculature permeability. dep 23-26 interleukin 6 Homo sapiens 114-118 25749775-13 2015 Dexamethasone, calcitriol, anti-MD2/anti-TLR2 antibodies, and signalling inhibitors significantly reduced LPS+Der p2-induced IL-6/IL-8 secretion. Dexamethasone 0-13 interleukin 6 Homo sapiens 125-129 25384728-7 2015 In the T1DM group, IL6-174CC carriers showed higher concentrations of glycated hemoglobin (p = 0.029), albumin-to-creatinine ratio (p = 0.021), total cholesterol (p = 0.010), and LDL-cholesterol (p = 0.002), when compared with GG+GC carriers. Cholesterol 150-161 interleukin 6 Homo sapiens 19-22 25857619-13 2015 Exposure to lipopolysaccharide induced a dramatic increase in both NF-kappaB activation and IL-6 expression in both wt and mdx myotubes, suggesting that the altered IL-6 gene expression after electrical stimulation in mdx muscle cells is due to dysregulation of Ca2+ release and ROS production, both of which impinge on NF-kappaB signaling. ros 279-282 interleukin 6 Homo sapiens 165-169 25908506-7 2015 In stratified analyses, participants randomized to vitamin D3 who lost 5% to 10% of baseline weight, versus participants who gained weight/had no weight-loss, had significantly greater decreases in levels of IL6 compared with those randomized to placebo: absolute change -0.75 pg/mL (-17.2%), placebo versus -1.77 pg/mL (-37.3%), vitamin D, P = 0.004. Vitamin D 51-60 interleukin 6 Homo sapiens 208-211 25384728-0 2015 Association of polymorphisms in IL6 gene promoter region with type 1 diabetes and increased albumin-to-creatinine ratio. Creatinine 103-113 interleukin 6 Homo sapiens 32-35 25384728-7 2015 In the T1DM group, IL6-174CC carriers showed higher concentrations of glycated hemoglobin (p = 0.029), albumin-to-creatinine ratio (p = 0.021), total cholesterol (p = 0.010), and LDL-cholesterol (p = 0.002), when compared with GG+GC carriers. Creatinine 114-124 interleukin 6 Homo sapiens 19-22 25844698-16 2015 The interleukin-6/interleukin-10 ratio directly correlated with plasma lactate. Lactic Acid 71-78 interleukin 6 Homo sapiens 4-17 25384728-7 2015 In the T1DM group, IL6-174CC carriers showed higher concentrations of glycated hemoglobin (p = 0.029), albumin-to-creatinine ratio (p = 0.021), total cholesterol (p = 0.010), and LDL-cholesterol (p = 0.002), when compared with GG+GC carriers. Cholesterol 183-194 interleukin 6 Homo sapiens 19-22 25384728-9 2015 CONCLUSIONS: These results suggest that IL6-174G>C may contribute to T1DM and increased albumin-to-creatinine ratio as well as to poor glycemic control and hyperlipidemia. Creatinine 102-112 interleukin 6 Homo sapiens 40-43 26125603-4 2015 Cypermethrin decreased CAT reporter expression induced by IL-6 (50 ng/ml), and the significant inhibition was detected at 10(-5)M (P<0.05). cypermethrin 0-12 interleukin 6 Homo sapiens 58-62 26125603-6 2015 Cypermethrin exhibits inhibitory effects on IL-6-induced ligand-independent AR signaling. cypermethrin 0-12 interleukin 6 Homo sapiens 44-48 26125603-0 2015 Antagonism effects of cypermethrin on interleukin-6-induced androgen receptor activation. cypermethrin 22-34 interleukin 6 Homo sapiens 38-51 26125603-7 2015 We provide a novel insight into cypermethrin-mediated antagonism of the IL-6-mediated ligand-independent activation of the AR. cypermethrin 32-44 interleukin 6 Homo sapiens 72-76 26125603-1 2015 To identify whether androgen receptor (AR) antagonism by cypermethrin involves interleukin-6 (IL-6)-induced ligand-independent AR signaling, we have developed the AR reporter gene assay. cypermethrin 57-69 interleukin 6 Homo sapiens 79-92 26125603-1 2015 To identify whether androgen receptor (AR) antagonism by cypermethrin involves interleukin-6 (IL-6)-induced ligand-independent AR signaling, we have developed the AR reporter gene assay. cypermethrin 57-69 interleukin 6 Homo sapiens 94-98 25546122-3 2015 The purpose of this review is to highlight and evaluate novel mechanisms by which dietary pro-oxidants, including bioactive phytochemicals and fatty acids, increase reactive oxygen species (ROS) concentrations just enough to activate transcription factor activation of nuclear factor erythroid 2 related factor 2 (Nrf-2) and heat shock factor (HSF), leading to an increase in levels of antioxidant enzymes and heat shock proteins that protect against the damaging effects of ROS. Fatty Acids 143-154 interleukin 6 Homo sapiens 325-342 25546122-3 2015 The purpose of this review is to highlight and evaluate novel mechanisms by which dietary pro-oxidants, including bioactive phytochemicals and fatty acids, increase reactive oxygen species (ROS) concentrations just enough to activate transcription factor activation of nuclear factor erythroid 2 related factor 2 (Nrf-2) and heat shock factor (HSF), leading to an increase in levels of antioxidant enzymes and heat shock proteins that protect against the damaging effects of ROS. Fatty Acids 143-154 interleukin 6 Homo sapiens 344-347 25546122-3 2015 The purpose of this review is to highlight and evaluate novel mechanisms by which dietary pro-oxidants, including bioactive phytochemicals and fatty acids, increase reactive oxygen species (ROS) concentrations just enough to activate transcription factor activation of nuclear factor erythroid 2 related factor 2 (Nrf-2) and heat shock factor (HSF), leading to an increase in levels of antioxidant enzymes and heat shock proteins that protect against the damaging effects of ROS. Reactive Oxygen Species 165-188 interleukin 6 Homo sapiens 325-342 25546122-3 2015 The purpose of this review is to highlight and evaluate novel mechanisms by which dietary pro-oxidants, including bioactive phytochemicals and fatty acids, increase reactive oxygen species (ROS) concentrations just enough to activate transcription factor activation of nuclear factor erythroid 2 related factor 2 (Nrf-2) and heat shock factor (HSF), leading to an increase in levels of antioxidant enzymes and heat shock proteins that protect against the damaging effects of ROS. Reactive Oxygen Species 165-188 interleukin 6 Homo sapiens 344-347 25738264-0 2015 Testosterone enhances lipopolysaccharide-induced interleukin-6 and macrophage chemotactic protein-1 expression by activating the extracellular signal-regulated kinase 1/2/nuclear factor-kappaB signalling pathways in 3T3-L1 adipocytes. Testosterone 0-12 interleukin 6 Homo sapiens 49-62 25738264-7 2015 Testosterone induces IL-6 and MCP-1, and enhances LPS-induction of IL-6 and MCP-1. Testosterone 0-12 interleukin 6 Homo sapiens 21-25 25738264-7 2015 Testosterone induces IL-6 and MCP-1, and enhances LPS-induction of IL-6 and MCP-1. Testosterone 0-12 interleukin 6 Homo sapiens 67-71 25738264-10 2015 The effect of testosterone on the expression of IL-6 and MCP-1 is inhibited by PD98059 , an ERK1/2 inhibitor, and PDTC, an NF-kappaB inhibitor. Testosterone 14-26 interleukin 6 Homo sapiens 48-52 25738264-10 2015 The effect of testosterone on the expression of IL-6 and MCP-1 is inhibited by PD98059 , an ERK1/2 inhibitor, and PDTC, an NF-kappaB inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 79-86 interleukin 6 Homo sapiens 48-52 25738264-11 2015 The results indicate that testosterone enhances LPS-induced IL-6 and MCP-1 expression by activating the ERK1/2/NF-kappaB signalling pathways in 3T3-L1 adipocytes. Testosterone 26-38 interleukin 6 Homo sapiens 60-64 25546122-3 2015 The purpose of this review is to highlight and evaluate novel mechanisms by which dietary pro-oxidants, including bioactive phytochemicals and fatty acids, increase reactive oxygen species (ROS) concentrations just enough to activate transcription factor activation of nuclear factor erythroid 2 related factor 2 (Nrf-2) and heat shock factor (HSF), leading to an increase in levels of antioxidant enzymes and heat shock proteins that protect against the damaging effects of ROS. Reactive Oxygen Species 190-193 interleukin 6 Homo sapiens 325-342 25546122-3 2015 The purpose of this review is to highlight and evaluate novel mechanisms by which dietary pro-oxidants, including bioactive phytochemicals and fatty acids, increase reactive oxygen species (ROS) concentrations just enough to activate transcription factor activation of nuclear factor erythroid 2 related factor 2 (Nrf-2) and heat shock factor (HSF), leading to an increase in levels of antioxidant enzymes and heat shock proteins that protect against the damaging effects of ROS. Reactive Oxygen Species 190-193 interleukin 6 Homo sapiens 344-347 26166660-11 2015 CONCLUSIONS: These results suggest that apigenin may inhibit IS-induced ER stress and expression of IL-6 and p21 proteins in HK-2 cells. Apigenin 40-48 interleukin 6 Homo sapiens 100-104 26107738-4 2015 Here, we report that vitamin D treatment during differentiation of monocytes into DCs markedly enhanced their ability to secrete TNF-alpha, IL-6, IL-1beta and IL-23. Vitamin D 21-30 interleukin 6 Homo sapiens 140-144 26107738-6 2015 Finally, we found that the differentiation of IL-22-producing T cells mediated by supernatants of vitamin D-treated DCs was dependent on TNF-alpha IL-6 and IL-23. Vitamin D 98-107 interleukin 6 Homo sapiens 147-151 25852008-7 2015 The intracellular calcium chelator BAPTA-AM blunted l-C16 carnitine-mediated IL-6 production by >65%. Calcium 18-25 interleukin 6 Homo sapiens 77-81 28531388-10 2015 Resistin mRNA expression significantly correlated with changes in HbA1c and TNF-alpha and IL-6 levels, all of which are strongly associated with glucose metabolism and/or inflammation. Glucose 145-152 interleukin 6 Homo sapiens 90-94 25626519-4 2015 Our results show that SAB significantly inhibited the UVB-induced expression of metalloproteinases-1 (MMP-1) and interleukin-6 (IL-6) while promoting the production of type I procollagen and transforming growth factor beta1 (TGF-beta1). salvianolic acid B 22-25 interleukin 6 Homo sapiens 113-126 25626519-4 2015 Our results show that SAB significantly inhibited the UVB-induced expression of metalloproteinases-1 (MMP-1) and interleukin-6 (IL-6) while promoting the production of type I procollagen and transforming growth factor beta1 (TGF-beta1). salvianolic acid B 22-25 interleukin 6 Homo sapiens 128-132 25497276-9 2015 The decrease in salt intake was accompanied by reduced production of proinflammatory cytokines interleukin (IL)-6 and IL-23, along with enhanced producing ability of anti-inflammatory cytokine IL-10. Salts 16-20 interleukin 6 Homo sapiens 95-113 25058850-6 2015 MDP (an NLRC2 agonist), NAC and AZM, but not Tri-DAP (an NLRC1 agonist), increased IL-6 production in CF cells, indicating that in CF cells IL-6 upregulation is independent of NLRC1, but involves the activation of NLRC2. Acetylcysteine 24-27 interleukin 6 Homo sapiens 83-87 25058850-6 2015 MDP (an NLRC2 agonist), NAC and AZM, but not Tri-DAP (an NLRC1 agonist), increased IL-6 production in CF cells, indicating that in CF cells IL-6 upregulation is independent of NLRC1, but involves the activation of NLRC2. Acetylcysteine 24-27 interleukin 6 Homo sapiens 140-144 26205020-14 2015 INTERPRETATION & CONCLUSIONS: The findings showed that IL-6, vitamin D, and diabetes risk factors were favourably modified by a short-term yoga-based lifestyle intervention in obesity. Adenosine Monophosphate 16-19 interleukin 6 Homo sapiens 59-63 26261550-5 2015 Results demonstrated that high glucose promoted the pre-inflammatory cytokines, such as TNF-alpha, IL-1beta and IL-6 in patients with T2DM or in SV40 MES 13 cells. Glucose 31-38 interleukin 6 Homo sapiens 112-116 25363661-7 2015 While a number of key immunosuppressive cytokines were overexpressed in the treated cells, including IL-10, IL-6 and GM-CSF, suppression could be alleviated in a number of treated GBM lines by inhibition of prostaglandin E2. Dinoprostone 207-223 interleukin 6 Homo sapiens 108-112 25612073-4 2015 Interleukin-6 (IL-6), interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) secretion levels significantly decreased in the presence of metal particles, as measured by ELISA. Metals 156-161 interleukin 6 Homo sapiens 0-13 25530272-7 2015 The expression of IL-6 from human fibroblast-like synoviocytes (FLSs) after incubation with various doses of Tubastatin A (0, 0.75, 1.5, 3 mumol/L) was measured using ELISA. tubastatin A 109-121 interleukin 6 Homo sapiens 18-22 25530272-12 2015 The expression of IL-6 in human FLSs decreased dose-dependently after incubation with Tubastatin A without affecting cell viability. tubastatin A 86-98 interleukin 6 Homo sapiens 18-22 25612073-4 2015 Interleukin-6 (IL-6), interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) secretion levels significantly decreased in the presence of metal particles, as measured by ELISA. Metals 156-161 interleukin 6 Homo sapiens 15-19 25787249-7 2015 Results of this study indicate that LncRNA MALAT1 regulates glucose-induced up-regulation of inflammatory mediators IL-6 and TNF-alpha through activation of SAA3. Glucose 60-67 interleukin 6 Homo sapiens 116-120 25787755-4 2015 In oxLDL-stimulated cells the parent anthocyanin had no effect on IL-6 production, whereas numerous anthocyanin metabolites significantly reduced IL-6 protein levels; phase II conjugates of protocatechuic acid produced the greatest effects (>75% reduction, p <= 0.05). protocatechuic acid 190-209 interleukin 6 Homo sapiens 146-150 25943392-4 2015 Our recent results indicated that IL6 secreted by OVCA cells may promote the resistance of these cells to TAM via ER isoforms and steroid hormone receptor coactivator-1. Tamoxifen 106-109 interleukin 6 Homo sapiens 34-37 25943392-6 2015 Results of further investigation indicate that IL6 phosphorylates ERalpha at Ser118 and Ser167 by triggering activation of MEK/ERK and phosphotidylinositol 3 kinase/Akt signaling, respectively, to activate the ER pathway and thereby induce OVCA cells resistance to TAM. Tamoxifen 265-268 interleukin 6 Homo sapiens 47-50 25943392-7 2015 These results indicate that IL6 secreted by OVCA cells may also contribute to the refractoriness of these cells to TAM via the crosstalk between ER and IL6-mediated intracellular signal transduction cascades. Tamoxifen 115-118 interleukin 6 Homo sapiens 28-31 25943392-9 2015 Our results indicate that TAM-IL6-targeted adjunctive therapy may lead to a more effective intervention than TAM alone. Tamoxifen 26-29 interleukin 6 Homo sapiens 30-33 26091457-9 2015 In addition, patients with preoperative serum IL-6 levels over 3.1 pg/mL had lower RFS and OS rates (P < 0.01). Osmium 91-93 interleukin 6 Homo sapiens 46-50 25556347-8 2015 Importantly, known suppressive effects of dexamethasone, a drug employed for the treatment of inflammatory bowel diseases, on leucocyte migration, IL8, IL6, and TNF-alpha production as well as CD86 surface expression by myeloid cells were observed in this model. Dexamethasone 42-55 interleukin 6 Homo sapiens 152-155 25943392-0 2015 IL6 induces TAM resistance via kinase-specific phosphorylation of ERalpha in OVCA cells. Tamoxifen 12-15 interleukin 6 Homo sapiens 0-3 26221308-8 2015 We found hydrogen-rich solutions treatment groups showed the decreased MDA, MPO, IL-6 and TNF-alpha levels, and increased SOD, IL-10 comparing with those of non-hydrogen solutions administration groups. Hydrogen 9-17 interleukin 6 Homo sapiens 81-85 26040375-9 2015 Interleukin-6 correlated positively with levels of C-reactive protein and negatively with blood glucose. Glucose 96-103 interleukin 6 Homo sapiens 0-13 26056431-13 2015 As expected, RA inhibited proinflammatory cytokines and microRNAs related to inflammation, suggesting that RA may suppress the Warburg effect via an inflammatory pathway, such as that involving interleukin (IL)-6/signal transducer and activator of transcription-3 (STAT3). rosmarinic acid 13-15 interleukin 6 Homo sapiens 194-212 25933972-6 2015 Here, we investigated the precise mechanism by which LU8C-FP inhibited phorbol 12-myristate 13-acetate-induced IL-6 mRNA and protein expression. lu8c-fp 53-60 interleukin 6 Homo sapiens 111-115 25933972-6 2015 Here, we investigated the precise mechanism by which LU8C-FP inhibited phorbol 12-myristate 13-acetate-induced IL-6 mRNA and protein expression. Tetradecanoylphorbol Acetate 71-102 interleukin 6 Homo sapiens 111-115 26030257-0 2015 Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors. Adenosine Triphosphate 67-70 interleukin 6 Homo sapiens 36-40 26030257-6 2015 These results suggest that UVA-induced IL-6 production is mediated by release of ATP through hemichannels and P2X7 receptor, followed by activation of P2Y11 and P2Y13 receptors. Adenosine Triphosphate 81-84 interleukin 6 Homo sapiens 39-43 26030257-8 2015 Thus, IL-6 production in response to UVA-induced ATP release involves at least two distinct pathways, mediated by activation of P2Y11 and P2Y13 receptors. Adenosine Triphosphate 49-52 interleukin 6 Homo sapiens 6-10 26025192-8 2015 CONCLUSIONS: Our data suggest that TNF-alpha and IL-6, but not CRP, are associated with the prevalence and severity of CKD, independent from established CKD risk factors, history of cardiovascular disease, and use of antihypertensive, antidiabetic, and lipid-lowering agents and aspirin. Aspirin 279-286 interleukin 6 Homo sapiens 49-53 26001192-12 2015 IL-6 and MCP-1 secretions from control and TREK-1 deficient cells after TNF-alpha+jasplakinolide or TNF-alpha+nocodazole treatment was similar to the effect of TNF-alpha alone. Nocodazole 110-120 interleukin 6 Homo sapiens 0-4 26056431-13 2015 As expected, RA inhibited proinflammatory cytokines and microRNAs related to inflammation, suggesting that RA may suppress the Warburg effect via an inflammatory pathway, such as that involving interleukin (IL)-6/signal transducer and activator of transcription-3 (STAT3). rosmarinic acid 107-109 interleukin 6 Homo sapiens 194-212 25843793-3 2015 Although Norepinephrine (NE) can stimulate the vascular cells to produce IL-6, it is unknown whether NE induces IL-6 expression in macrophages. Norepinephrine 9-23 interleukin 6 Homo sapiens 73-77 25843793-9 2015 These demonstrate that NE is capable of inducing IL-6 generation in macrophages via beta-ADR-ROS-NF-kappaB signal pathway, which contributes to better understanding of the proinflammatory and proatherosclerotic actions of NE. Reactive Oxygen Species 93-96 interleukin 6 Homo sapiens 49-53 25961579-0 2015 Inhibition of IL-6 signaling pathway by curcumin in uterine decidual cells. Curcumin 40-48 interleukin 6 Homo sapiens 14-18 25961745-8 2015 3-MA, NAC and DPI inhibited HG-induced interleukin-6 production in BMSCs. 3-methyladenine 0-4 interleukin 6 Homo sapiens 39-52 25869100-12 2015 Interestingly, STAT-3 over expression or STAT-3 activation by IL-6, significantly increased the levels of beta-catenin and attenuated the effects of capsaicin in inhibiting beta-catenin signaling. Capsaicin 149-158 interleukin 6 Homo sapiens 62-66 25961745-8 2015 3-MA, NAC and DPI inhibited HG-induced interleukin-6 production in BMSCs. Acetylcysteine 6-9 interleukin 6 Homo sapiens 39-52 25961579-6 2015 Therefore, we examined the effect of curcumin on IL-6 expression using two types of uterine decidual cells 1) HuF cells, primary human fibroblast cells obtained from the decidua parietalis; 2) UIII cells, a rodent non-transformed decidual cell line. Curcumin 37-45 interleukin 6 Homo sapiens 49-53 25961579-7 2015 Curcumin treatment completely abrogated the expression of IL-1beta-induced IL-6 in these cells. Curcumin 0-8 interleukin 6 Homo sapiens 75-79 25961579-8 2015 Curcumin also strongly inhibited the expression of gp130, a critical molecule in IL-6 signaling, whereas expression of IL-6R and sIL-6R was not affected. Curcumin 0-8 interleukin 6 Homo sapiens 81-85 25961579-9 2015 Curcumin also inhibited phosphorylation and nuclear localization of STAT3, a well-known downstream mediator of IL-6 signaling. Curcumin 0-8 interleukin 6 Homo sapiens 111-115 25961579-10 2015 Furthermore, curcumin attenuated IL-1beta-induced IL-6 promoter reporter activity suggesting transcriptional regulation. Curcumin 13-21 interleukin 6 Homo sapiens 50-54 25943109-11 2015 Additionally, LPS pre-incubation: 1) reduced dexamethasone"s capacity to inhibit FBS-induced IL-6, CXCL8 and RANTES, 2) reduced dexamethasone-induced GRalpha nuclear translocation (only in NM fibroblasts), 3) did not alter GRalpha/GRbeta expression, 4) decreased GILZ expression, and 5) did not affect dexamethasone"s capacity to induce MKP-1 and GILZ expression. Dexamethasone 45-58 interleukin 6 Homo sapiens 93-97 25704613-10 2015 In EA.hy926 cells, DLC significantly inhibited the histamine- and LPS- induced IL-6 and IL-8 production and P-selectin and intercellular cell adhesion molecule-1 (ICAM-1) expression. Histamine 51-60 interleukin 6 Homo sapiens 79-83 25942007-6 2015 Inhibition of PI3K with LY294002 and wortmannin, and of mTORC1 with rapamycin decreased flagellin-induced TNF-alpha and IL-6 expression and cell proliferation. Sirolimus 68-77 interleukin 6 Homo sapiens 120-124 24985791-7 2015 IL-6 and MIP-1beta levels in NPA were directly correlated to oxygen therapy. Oxygen 61-67 interleukin 6 Homo sapiens 0-4 25748833-0 2015 Matrix metalloproteinases regulate extracellular levels of SDF-1/CXCL12, IL-6 and VEGF in hydrogen peroxide-stimulated human periodontal ligament fibroblasts. Hydrogen Peroxide 90-107 interleukin 6 Homo sapiens 73-77 25358442-7 2015 RESULTS: Dexamethasone reduced LPS-induced TNFalpha, IL-6 and CXCL-8 in all groups, but maximum inhibition was significantly reduced for GINA3/4 compared with GINA2 and GINA1 (P < 0.01). Dexamethasone 9-22 interleukin 6 Homo sapiens 53-57 25701642-8 2015 Interleukin 6 was increased in patients and presented an inverse correlation with GSH levels, showing a possible link between inflammation and oxidative stress in MPS IVA disease. Glutathione 82-85 interleukin 6 Homo sapiens 0-13 25774595-0 2015 Risk model incorporating donor IL6 and IFNG genotype and gastrointestinal GVHD can discriminate patients at high risk of steroid refractory acute GVHD. Steroids 121-128 interleukin 6 Homo sapiens 31-34 25593123-10 2015 Currently, IL-6, secreted protein acidic and rich in cysteine, angiopoietin-like 4, chemokine (C-X3-C motif) ligand 1, and chemokine (C-C motif) ligand 2 have the highest potential to serve as exercise factors because for all these factors, there is clear evidence that plasma levels increase during exercise. Cysteine 53-61 interleukin 6 Homo sapiens 11-15 25710246-8 2015 RESULTS: After controlling for confounders, 5 microg/m increase in long-term ambient PM2.5 was associated with 6% higher IL-6 (95% confidence interval = 2%, 9%), and 40 parts per billion increase in long-term NOx was associated with 7% (95% confidence interval = 2%, 13%) higher level of D-dimer. nicotine 1-N-oxide 209-212 interleukin 6 Homo sapiens 121-125 25546398-10 2015 GL-CM did not alter the release of IL-6 by macrophages, although treatment with ATP promoted an increase in the release of IL-6, which was prevented by a P2X7 antagonist. Adenosine Triphosphate 80-83 interleukin 6 Homo sapiens 123-127 25355803-6 2015 Changes in cytokine secretion (interleukin 6 [IL-6] and tumor necrosis factor alpha [TNF-alpha]) by Mphi and proliferation of ESCs in response to single and combined treatment with E2 and LPS were measured by enzyme-linked immunosorbent assay and by bromodeoxyuridine incorporation assay, respectively. Estradiol 181-183 interleukin 6 Homo sapiens 46-50 25893499-11 2015 Moreover, exogenously PGE2 added alone induced IL-6 production and completely rescued IL-6 transcription when added simultaneously with FSL-1 in the presence of a cPLA2alpha inhibitor. Dinoprostone 22-26 interleukin 6 Homo sapiens 47-51 26081514-8 2015 In metformin-treated cells, the expressions of Arg1 (P = 0.009), IL-10 (P = 0.015) and IL-4 (P = 0.001) mRNA increased while the expressions of IL-1beta (P = 0.001) and IL-6 (P = 0.032) mRNA decreased. Metformin 3-12 interleukin 6 Homo sapiens 169-173 25893499-11 2015 Moreover, exogenously PGE2 added alone induced IL-6 production and completely rescued IL-6 transcription when added simultaneously with FSL-1 in the presence of a cPLA2alpha inhibitor. Dinoprostone 22-26 interleukin 6 Homo sapiens 86-90 25673640-2 2015 In this study, we demonstrate that immune suppression with cyclosporin after SCT limits T-helper cell (Th) 1 differentiation and interferon-gamma secretion by donor T cells, which is critical for inhibiting interleukin (IL)-6 generation from lung parenchyma during an alloimmune response. Cyclosporine 59-70 interleukin 6 Homo sapiens 207-225 26131181-9 2015 Compared to patients with OH < 1.5 L, patients with SCOH >= 1.5 L had higher levels of blood pressure, peritoneal glucose load, plasma brain natriuretic peptide, high sensitive C-reactive protein, interleukin-6 and LVMI; and lower levels of serum albumin (P < 0.001). scoh 55-59 interleukin 6 Homo sapiens 203-216 25926797-3 2015 In this study, we used an in vitro model of human adipose tissue inflammation to examine the effects of resveratrol on the production of the inflammatory cytokines interleukin 6 (IL-6), IL-8, and monocyte chemoattractant protein 1 (MCP-1). Resveratrol 104-115 interleukin 6 Homo sapiens 164-177 25926797-3 2015 In this study, we used an in vitro model of human adipose tissue inflammation to examine the effects of resveratrol on the production of the inflammatory cytokines interleukin 6 (IL-6), IL-8, and monocyte chemoattractant protein 1 (MCP-1). Resveratrol 104-115 interleukin 6 Homo sapiens 179-183 25926797-4 2015 We found that resveratrol reduced IL-6, IL-8, and MCP-1 levels in a concentration-dependent manner in adipocytes under inflammatory conditions. Resveratrol 14-25 interleukin 6 Homo sapiens 34-38 25673640-6 2015 Furthermore, at the time of diagnosis, plasma IL-6 levels were higher in a subset of IPS patients who were nonresponsive to steroids and anti-tumor necrosis factor therapy. Steroids 124-132 interleukin 6 Homo sapiens 46-50 25647267-6 2015 17beta-estradiol elevated resistin but decreased adiponectin and IL-6 levels; however, it did not alter the concentration of leptin and TNF-alpha. Estradiol 0-16 interleukin 6 Homo sapiens 65-69 25849993-5 2015 Furthermore, release in ROS owing to TLR-4 signaling resulted in the activation of NF-kappaB p65 nuclear translocation which leads to inflammation and apoptosis via TNF receptor pathway following the increase in IL-6 and TNF-alpha level. Reactive Oxygen Species 24-27 interleukin 6 Homo sapiens 212-216 25619393-8 2015 Pretreatment of the cells with DTT (500 mumol/L) or GSH (500 mumol/L) eliminated the inhibitory effects of bigelovin on the IL-6-induced and the constitutive STAT3 activation. Glutathione 52-55 interleukin 6 Homo sapiens 124-128 25856395-5 2015 Curcumin pre-treatment also abrogated the gp120-mediated upregulation of the proinflammatory cytokines tumor necrosis factor-alpha and interleukin (IL)-6, which mediate barrier disruption, as well as the chemokines IL-8, RANTES and interferon gamma-induced protein-10 (IP-10), which are capable of recruiting HIV target cells to the FGT. Curcumin 0-8 interleukin 6 Homo sapiens 135-153 25394884-5 2015 RESULTS: Increasing concentrations of glucose significantly increased trophoblast secretion of the inflammatory cytokines/chemokines: IL-1beta, IL-6, IL-8, GRO-alpha, RANTES, and G-CSF; significantly increased trophoblast secretion of the anti-angiogenic factors sFlt-1 and sEndoglin; and significantly decreased trophoblast migration. Glucose 38-45 interleukin 6 Homo sapiens 144-148 26167343-12 2015 TNF-alpha (r=-0.763) and IL-6 levels (r=-0.947) showed strong negative correlations, PON1 activity (r=0.644) and HDL-cholesterol levels (r=0.477) showed positive correlations with patient survival (p<0.001 for all). Cholesterol 117-128 interleukin 6 Homo sapiens 25-29 25681539-5 2015 The endothelial production of high-glucose-induced interleukin (IL)-4, IL-6, IL-13 and signal transducer and activator of transcription-3 (STAT-3) phosphorylation were significantly inhibited by the pretreatment with GA at concentrations of 10, 15 and 20muM based on enzyme-linked immunosorbent assay (ELISA), western blot or/and RT-PCR experiments. Glucose 35-42 interleukin 6 Homo sapiens 71-75 25701505-4 2015 Treatment of LPS-stimulated macrophages with 70kGy gamma-irradiated resveratrol resulted in a dose-dependent decrease in iNOS-mediated NO, PGE2, and pro-inflammatory cytokine level, such as TNF-alpha, IL-6 and IL-1beta. Resveratrol 68-79 interleukin 6 Homo sapiens 201-205 25660662-4 2015 The results show that production of IL-1beta, IL-6 and IL-8 was significantly higher in the group of methadone-maintained patients than in the healthy control group. Methadone 101-110 interleukin 6 Homo sapiens 46-50 25779760-8 2015 H2O2 enhanced reactive oxygen species, interleukin-6, tumor necrosis factor-alpha, and prostaglandin E2 levels in test cells. Hydrogen Peroxide 0-4 interleukin 6 Homo sapiens 39-81 24803523-7 2015 RESULTS: At T2, the levels of IL-6 and IL-10 in the saline group were elevated significantly compared with at T0 or T1 (IL-6: 119.62 and 15.97 pg/mL at T2 and T0, respectively [P = .042]; IL-10: 27.27 and 7.03 pg/mL at T2 and T1, respectively [P = .037]). Sodium Chloride 52-58 interleukin 6 Homo sapiens 30-34 24803523-7 2015 RESULTS: At T2, the levels of IL-6 and IL-10 in the saline group were elevated significantly compared with at T0 or T1 (IL-6: 119.62 and 15.97 pg/mL at T2 and T0, respectively [P = .042]; IL-10: 27.27 and 7.03 pg/mL at T2 and T1, respectively [P = .037]). Sodium Chloride 52-58 interleukin 6 Homo sapiens 120-124 25625841-8 2015 Treatment with an anti-human IL-6 receptor monoclonal antibody reduced spheroid formation, stem cell-related gene expression, and 5-fluorouracil (5-FU) resistance. Fluorouracil 130-144 interleukin 6 Homo sapiens 29-33 25625841-8 2015 Treatment with an anti-human IL-6 receptor monoclonal antibody reduced spheroid formation, stem cell-related gene expression, and 5-fluorouracil (5-FU) resistance. Fluorouracil 146-150 interleukin 6 Homo sapiens 29-33 25625841-9 2015 In addition, IL-6 treatment enhanced the levels of p-STAT3 (Tyr705), the expression of Oct-4, Klf4, Lgr5, and Notch 3, and chemoresistance to 5-FU. Fluorouracil 142-146 interleukin 6 Homo sapiens 13-17 25616597-12 2015 Interestingly, the very same sequence also responded to interleukin-6 (IL-6), and primary hepatocytes treated with thapsigargin significantly increased the level of IL-6 mRNA. Thapsigargin 115-127 interleukin 6 Homo sapiens 56-69 25616597-12 2015 Interestingly, the very same sequence also responded to interleukin-6 (IL-6), and primary hepatocytes treated with thapsigargin significantly increased the level of IL-6 mRNA. Thapsigargin 115-127 interleukin 6 Homo sapiens 71-75 25616597-12 2015 Interestingly, the very same sequence also responded to interleukin-6 (IL-6), and primary hepatocytes treated with thapsigargin significantly increased the level of IL-6 mRNA. Thapsigargin 115-127 interleukin 6 Homo sapiens 165-169 25660662-5 2015 Plasma TNF-alpha and IL-6 levels were significantly correlated with the dairy methadone dosage administered, and the IL-1beta level was significantly correlated with the duration of methadone maintenance treatment. Methadone 78-87 interleukin 6 Homo sapiens 21-25 25861245-0 2015 TNF-alpha and IL-6 inhibit apolipoprotein A-IV production induced by linoleic acid in human intestinal Caco2 cells. Linoleic Acid 69-82 interleukin 6 Homo sapiens 14-18 25826533-10 2015 In hepatocytes, 2-AG induced the expression of IL-6, -17A, -32 and COX-2, and enhanced activation of hepatic stellate cells (HSC) co-cultivated with PBMC from subjects with CHC. glyceryl 2-arachidonate 16-20 interleukin 6 Homo sapiens 47-51 27275202-8 2015 In comparing the pre &post acupuncture results of TNF-alpha, IL-6 and hsCRP showed high significant reduction after acupuncture. Adenosine Monophosphate 22-25 interleukin 6 Homo sapiens 65-69 25785838-0 2015 Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFalpha-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction. Dinoprostone 97-101 interleukin 6 Homo sapiens 111-115 25785838-4 2015 Moreover, gastric cancer cells secreted PGE2 and TNFalpha that stimulated IL-6 secretion by the stromal cells. Dinoprostone 40-44 interleukin 6 Homo sapiens 74-78 25821432-6 2015 Bile acids also prevented the upregulation of interleukin-6 mRNA, whereas only ursodeoxycholic acid abrogated cytokine release. Bile Acids and Salts 0-10 interleukin 6 Homo sapiens 46-59 24786562-13 2015 Changes in normalized IL-6 and IL-8 levels upon treatment with L-mimosine did not reach the level of significance (P > 0.05), whilst treatment with IL-1, which served as positive control, increased IL-6 (P < 0.05) and IL-8 levels (P < 0.05). Mimosine 63-73 interleukin 6 Homo sapiens 22-26 25513788-13 2015 Plasma-free cortisol, plasma total cortisol, and plasma-free cortisol/plasma total cortisol were positively correlated with interleukin-6 (p = 0.0001, p < 0.0004, and p < 0.001, respectively) and day 90 mortality (p = 0.03, p = 0.03, and p = 0.058, respectively). Hydrocortisone 12-20 interleukin 6 Homo sapiens 124-137 25454806-4 2015 Pretreatment with UFH (0.1-1U/ml) significantly inhibited LPS (10mug/ml)-stimulated interleukin (IL)-6 and IL-8 production in HPMECs. Heparin 18-21 interleukin 6 Homo sapiens 84-102 25381629-0 2015 Effects of tadalafil administration on plasma markers of exercise-induced muscle damage, IL6 and antioxidant status capacity. Tadalafil 11-20 interleukin 6 Homo sapiens 89-92 25544427-4 2015 Silencing of IL-6 using IL-6 siRNA was found to suppress IL-6 production, STAT3 and phosphoSTAT3 levels, which eventually reduced proliferation and clonogenicity of taxol-resistant SKOV3/TR cells. Paclitaxel 165-170 interleukin 6 Homo sapiens 13-17 25544427-4 2015 Silencing of IL-6 using IL-6 siRNA was found to suppress IL-6 production, STAT3 and phosphoSTAT3 levels, which eventually reduced proliferation and clonogenicity of taxol-resistant SKOV3/TR cells. Paclitaxel 165-170 interleukin 6 Homo sapiens 24-28 25544427-4 2015 Silencing of IL-6 using IL-6 siRNA was found to suppress IL-6 production, STAT3 and phosphoSTAT3 levels, which eventually reduced proliferation and clonogenicity of taxol-resistant SKOV3/TR cells. Paclitaxel 165-170 interleukin 6 Homo sapiens 24-28 25544427-5 2015 In addition, stattic, a STAT3 inhibitor, was found to result in decrease of cell viability and clonogenicity of these cells, indicating that the elevated IL-6 and STAT3, phosphoSTAT3 levels are associated with the development of taxol resistance. Paclitaxel 229-234 interleukin 6 Homo sapiens 154-158 25544427-10 2015 Taken together, our data suggest that inhibition of IL-6/STAT3 signaling pathway and downregulation of Axl and Tyro3 RTKs expression might be a therapeutic strategy to overcome taxol resistance in ovarian cancer cells. Paclitaxel 177-182 interleukin 6 Homo sapiens 52-56 25410618-7 2015 Our data showed that high glucose induced the protein expressions of cyclooxygenase-2 (COX-2) and production of prostaglandin-E2 (PGE2 ), interleukin-6 (IL-6), and metalloproteinase-13 (MMP-13), but decreased the protein expression of collagen II and PPARgamma in human chondrocytes. Glucose 26-33 interleukin 6 Homo sapiens 138-151 25808165-10 2015 However, most of the metals including (V(+4), V(+5)), (Cr(+3), Cr(+6)), Zn, and Pb inhibited the production of both IL-6 and IL-8. Zinc 72-74 interleukin 6 Homo sapiens 116-120 25201048-10 2015 These results demonstrated that S1P-induced COX-2 expression and PGE2 /IL-6 generation was mediated through S1PR1/3/c-Src/PYK2/p42/p44 MAPK- or JNK1/2- and S1PR1/3/c-Src/p38 MAPK-dependent AP-1 activation. Dinoprostone 65-69 interleukin 6 Homo sapiens 71-75 25954613-11 2015 IL-6 was significantly correlated with total cholesterol in diabetic urolithiasis cases. Cholesterol 45-56 interleukin 6 Homo sapiens 0-4 25135658-9 2015 Serum IL-6 levels (pg/mL) were higher in the fatigued group (5.1 +- 3.4) than in the nonfatigued group (1.6 +- 1.5; P < 0.001); serum albumin and creatinine levels were significantly lower. Creatinine 149-159 interleukin 6 Homo sapiens 6-10 25373367-7 2015 The IL-6 blood concentration appears to have decreased with steroid treatment irrespective of changes in the state of sepsis, whereas bowel sound counts with the monitoring system reflected the changes in the state of sepsis, resulting in no correlation. Steroids 60-67 interleukin 6 Homo sapiens 4-8 25457208-8 2015 Moreover, ethanol (100 mM) and acetaldehyde (100 and 500 muM) increased levels of IL-6 and IFN-gamma, and suppressed autophagy in VA-13 cells, effects which were markedly alleviated by rapamycin. Ethanol 10-17 interleukin 6 Homo sapiens 82-86 25565656-3 2015 Inflammation, characterized by a rise in interleukin-6 (IL6), initiates the coagulation cascade, but low-dose steroids can reduce post-TKA IL6 levels. Steroids 110-118 interleukin 6 Homo sapiens 139-142 25410618-7 2015 Our data showed that high glucose induced the protein expressions of cyclooxygenase-2 (COX-2) and production of prostaglandin-E2 (PGE2 ), interleukin-6 (IL-6), and metalloproteinase-13 (MMP-13), but decreased the protein expression of collagen II and PPARgamma in human chondrocytes. Glucose 26-33 interleukin 6 Homo sapiens 153-157 26120598-6 2015 Further investigation into the effects of metformin suggest that the drug directly activates AMPK and dose-dependently suppressed the release of TNF-alpha, IL-6, and MCP-1 by macrophages while enhancing the release of IL-10 in vitro. Metformin 42-51 interleukin 6 Homo sapiens 156-160 25898559-8 2015 RESULTS: DP-M&O decreased the levels of TNF-alpha, IL-1beta, IL-6, and IL-8 and increased that of IL-10 in a concentration-dependent manner. Adenosine Monophosphate 14-17 interleukin 6 Homo sapiens 65-69 25455350-9 2015 In patients, we also observed a positive correlation between IL-6 and the tryptophan:KYNA ratio, indicating that IL-6 activates the KYN pathway. Tryptophan 74-84 interleukin 6 Homo sapiens 61-65 25455350-9 2015 In patients, we also observed a positive correlation between IL-6 and the tryptophan:KYNA ratio, indicating that IL-6 activates the KYN pathway. Tryptophan 74-84 interleukin 6 Homo sapiens 113-117 25710413-9 2015 Elevated TT levels at 6 hours were associated with elevated interleukin 6 levels and cytokine/chemokine measurements (18 of 24 measured). Testosterone 9-11 interleukin 6 Homo sapiens 60-73 25620665-7 2015 In addition, Srxn1 appeared to influence the strength of TLR4 signaling pathway; the expression of COX-2, IL-6, and NOS2 were strongly induced by OGD/R and H2O2 in astrocyte cultures with Srxn1-shRNAs. Hydrogen Peroxide 156-160 interleukin 6 Homo sapiens 106-110 25639781-8 2015 Multivariable analyses showed significant positive associations between the DII and the inflammatory markers IL-6 (>1 6 pg/ml) (OR 1 19, 95 % CI 1 04, 1 36) and homocysteine (>15 mumol/l) (OR 1 56, 95 % CI 1 25, 1 94). dilC18(3) dye 76-79 interleukin 6 Homo sapiens 109-113 25737638-0 2015 Effect of vitamin D therapy on interleukin-6, visfatin, and hyaluronic acid levels in chronic hepatitis C Egyptian patients. Vitamin D 10-19 interleukin 6 Homo sapiens 31-44 25576658-3 2015 In this paper we demonstrate that in LPS-stimulated microglia resveratrol pretreatment reduced, in a dose-dependent manner, pro-inflammatory cytokines IL-1beta, TNF-alpha and IL-6 mRNA expression and increased the release of anti-inflammatory interleukin (IL)-10. Resveratrol 62-73 interleukin 6 Homo sapiens 175-179 25648341-9 2015 Cyclosporine A treatment significantly reduced the mRNA expression levels of IL6 and TNFalpha in both short- and long-term treatments; however, it reduced MMP9 levels only in long-term treatment in cultured corneal epithelial cells. Cyclosporine 0-14 interleukin 6 Homo sapiens 77-80 25760537-5 2015 Pre-treatment with IL-6 enhanced the cytotoxic effects of gefitinib and paclitaxel. Gefitinib 58-67 interleukin 6 Homo sapiens 19-23 25760537-5 2015 Pre-treatment with IL-6 enhanced the cytotoxic effects of gefitinib and paclitaxel. Paclitaxel 72-82 interleukin 6 Homo sapiens 19-23 25303878-3 2015 In vitro treatment with naringenin led to a significant attenuation in the LPS-induced NHBE secretion of tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), superoxidase dismutase (SOD), nitricoxide synthase (NOS), myeloperoxidase (MPO), and nitric oxide (NO). naringenin 24-34 interleukin 6 Homo sapiens 146-159 25303878-3 2015 In vitro treatment with naringenin led to a significant attenuation in the LPS-induced NHBE secretion of tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), superoxidase dismutase (SOD), nitricoxide synthase (NOS), myeloperoxidase (MPO), and nitric oxide (NO). naringenin 24-34 interleukin 6 Homo sapiens 161-165 25303878-4 2015 RT-qPCR demonstrated that naringenin significantly reduced the LPS-induced upregulation of TNF-alpha, IL-6, and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) p65 mRNA expression in a dose-dependent manner. naringenin 26-36 interleukin 6 Homo sapiens 102-106 25303878-7 2015 Taken together, these demonstrate that naringenin reduces TNF-alpha and IL-6 secretion and mRNA expression, possibly by blocking the activation of the NF-kappaB and MAPK signaling pathways in LPS-treated NHBE. naringenin 39-49 interleukin 6 Homo sapiens 72-76 25901198-1 2015 We recently described the synthesis and characterization of a novel difluorinatedbenzylidene analog of curcumin, commonly referred as CDF, which demonstrated significantly enhanced bioavailability and in vivo anticancer activity. Curcumin 103-111 interleukin 6 Homo sapiens 134-137 25480923-6 2015 Exposure of PHH and HepaRG cells to IL-6 resulted in highly similar coordinated reduction of DMET mRNA, including major ATP-binding cassette transporters (ABCs), P450s, glutathione S-transferases (GSTs), uridine diphosphate glucuronosyltransferases (UGTs), and solute carriers (SLCs). ethyl 3,4-dioxobutyrate-di-(4,4-dimethylthiosemicarbazone) 93-97 interleukin 6 Homo sapiens 36-40 25528475-8 2015 Our results revealed that T11TS therapy induced downregulation of TNF-alpha, IL-8, IL-6, and NF-kappaB confirmed by FACS assay and ELISA. t11ts 26-31 interleukin 6 Homo sapiens 83-87 25256809-8 2015 T-cell receptor (TCR) activation of PBMCs and nickel (Ni(2+) ) treatments of human dermal microvascular endothelial cells (HDMECs) were performed resulting in IL-4, IL-6, IL-8 and IL-17 production. Nickel(2+) 54-60 interleukin 6 Homo sapiens 165-169 25375354-7 2015 IL-6 and hs-CRP were positively correlated with MDA, and negatively associated with SOD and GSH-PX. Glutathione 92-95 interleukin 6 Homo sapiens 0-4 25420918-4 2015 When DC maturation was induced by TLR agonists, reduced cytokine levels (IL-6, IL-1beta, and IL-12p70) were observed in Cl-amidine-treated DCs. N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide 120-130 interleukin 6 Homo sapiens 73-77 25212196-0 2015 Effective use of tocilizumab for the treatment of steroid-refractory gastrointestinal acute graft versus host disease in a child with very high levels of serum interleukin-6. Steroids 50-57 interleukin 6 Homo sapiens 160-173 25973018-12 2015 BCG induced HMGB1, IL-6, IL-10 and TNF-alpha production effectively in PMA-treated THP-1 cells. Tetradecanoylphorbol Acetate 71-74 interleukin 6 Homo sapiens 19-23 25440410-2 2015 A four-yr-old previously healthy male with restrictive cardiomyopathy required MCS after cardiac arrest but was diagnosed with multicentric CD, a non-malignant lymphoproliferative disorder fueled by excessive IL-6 production. Cadmium 140-142 interleukin 6 Homo sapiens 209-213 25861075-11 2015 Compared to traditional protocols, patients undergoing fasting abbreviation with the administration of fluids containing carbohydrates had improvements in glycemic parameters (fasting glucose and insulin resistance), inflammatory markers (interleukin 6 and 10) and indicators of malnutrition (grip strength hand and CRP/albumin ratio), and shorter hospital stay. Carbohydrates 121-134 interleukin 6 Homo sapiens 239-259 25504436-6 2015 Exogenous IL-6 treatment significantly enhances NOX4/ROS/Akt signaling in NSCLC cells. Reactive Oxygen Species 53-56 interleukin 6 Homo sapiens 10-14 25378535-6 2015 Further linking intracellular iron and inflammation, 14 SCD patients with a ferroportin Q248H variant that causes intracellular iron accumulation had significantly higher levels of interleukin-6 and C-reactive protein compared with 14 matched SCD patients with the wild-type allele (P<0.05). Iron 128-132 interleukin 6 Homo sapiens 181-194 24130267-2 2015 Activation of kainate (KA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors (GluRs) increase interleukin-6 (IL-6) release and cause arthritic pain, respectively. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 31-87 interleukin 6 Homo sapiens 132-145 24130267-2 2015 Activation of kainate (KA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors (GluRs) increase interleukin-6 (IL-6) release and cause arthritic pain, respectively. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 31-87 interleukin 6 Homo sapiens 147-151 24285492-11 2015 Extracellular and intracellular TLR4 inhibition as well as fatty acid transport inhibition blocked the palmitic acid-induced IL-6 secretion of RASF. Fatty Acids 59-69 interleukin 6 Homo sapiens 125-129 25455130-1 2015 OBJECTIVE: To investigate the relationship between ATP and IL-6 in mechanical stress-induced REX-1 expression in SHEDs. Adenosine Triphosphate 51-54 interleukin 6 Homo sapiens 59-63 25455130-9 2015 Exogenous IL-6 promoted both ATP release and REX-1 expression. Adenosine Triphosphate 29-32 interleukin 6 Homo sapiens 10-14 25790769-6 2015 RESULTS: Neither high glucose nor low LPS (<=5 ng/ml) alone had an effect on TNF-a and IL-6 levels, but the combination of low LPS and high glucose stimulated the inflammatory response. Glucose 143-150 interleukin 6 Homo sapiens 90-94 25476497-0 2015 Obesity-associated systemic interleukin-6 promotes pre-adipocyte aromatase expression via increased breast cancer cell prostaglandin E2 production. Dinoprostone 119-135 interleukin 6 Homo sapiens 28-41 25476497-9 2015 This study indicates that obesity-associated systemic IL-6 indirectly enhances pre-adipocyte aromatase expression via increased breast cancer cell PGE2 production. Dinoprostone 147-151 interleukin 6 Homo sapiens 54-58 26090459-5 2015 33-Hydroxyepigambogic acid and 35-hydroxyepigambogic acid exhibited about 1 muM IC50 values against JAK2/JAK3 kinases and less than 1 muM IC50 values against NCI-H1650 cell which autocrined IL-6. 33-Hydroxyepigambogic acid 0-26 interleukin 6 Homo sapiens 190-194 25115708-5 2015 Meanwhile, ATP was also able to stimulate the release of interleukin (IL)-6 and tumor necrosis factor-alpha (TNF-alpha), but fibronectin does not. Adenosine Triphosphate 11-14 interleukin 6 Homo sapiens 57-75 25998190-9 2015 RESULTS: Curcumin dose-dependently inhibited M1 macrophage polarization and the production of TNF-alpha, IL-6, and IL-12B (p40). Curcumin 9-17 interleukin 6 Homo sapiens 105-109 26279422-7 2015 Moderate hypoxia increased HIF1alpha expression and cell proliferation and acted by two different mechanisms to decrease IL-6 secretion compared with normoxia: it limits the TLR4 expression and ROS production. Reactive Oxygen Species 194-197 interleukin 6 Homo sapiens 121-125 26279422-8 2015 Treatment with cobalt chloride as an HIF1 activator inhibited IL-6 secretion and TLR4 expression; this effect was reversed on treatment with PX-12 as an HIF1 suppressor. 1-methylpropyl-2-imidazolyl disulfide 141-146 interleukin 6 Homo sapiens 62-66 25807640-10 2015 Multiple linear regression analyses adjusting CAF for inflammatory parameters (i.e., WBC, CRP, interleukin 6, PCT), age, and gender showed a strong correlation between CAF and creatinine (r = 0.643, p < 0.001). Creatinine 176-186 interleukin 6 Homo sapiens 95-108 26238371-6 2015 IL-1beta, IL-6, IL-8 and TNF-alpha production could be significantly upregulated and downregulated by a ROS activator or inhibitor, respectively. Reactive Oxygen Species 104-107 interleukin 6 Homo sapiens 10-14 25213007-2 2015 This increase in IL-6 is reported to have pleiotropic effects including increased glucose uptake, increased fat oxidation, and anti-inflammatory actions. Glucose 82-89 interleukin 6 Homo sapiens 17-21 24655315-8 2015 Serum total bilirubin, interleukin-6 and C-reactive protein were significantly lower in the steroid than in the control group on postoperative day 1 (P = 0.02, 0.004 and 0.02, respectively). Steroids 92-99 interleukin 6 Homo sapiens 23-36 25387665-5 2015 RESULTS: JTE-052 inhibited the JAK1, JAK2, JAK3, and tyrosine kinase (Tyk)2 enzymes in an adenosine triphosphate (ATP)-competitive manner and inhibited cytokine signaling evoked by IL-2, IL-6, IL-23, granulocyte/macrophage colony-stimulating factor, and IFN-alpha. Adenosine Triphosphate 114-117 interleukin 6 Homo sapiens 187-191 25330767-8 2015 The percent of SEB-stimulated IL-6 secretion (217.53% +- 89.51%) was also significantly reduced following exposure to verapamil (148.82% +- 79.15%, p < 0.05) but not dexamethasone (148.86% +- 145.24%). Dexamethasone 169-182 interleukin 6 Homo sapiens 30-34 26366318-9 2015 Modelling indicates that the significant predictors of CRP levels were biomarkers of the metabolic syndrome while the significant predictors of IL-6 levels were age and plasma triglycerides among former smokers and the numbers of smoked packs of cigarettes per year among smokers. Triglycerides 176-189 interleukin 6 Homo sapiens 144-148 25325880-6 2015 Associations between IL-6 and sICAM-1 and painful DSPN remained significant after additional adjustment for waist circumference, height, hypertension, cholesterol, smoking, alcohol intake, physical activity, history of myocardial infarction and/or stroke, presence of other neurological conditions, and use of nonsteroidal anti-inflammatory drugs (P = 0.005 and P = 0.016, respectively). Cholesterol 151-162 interleukin 6 Homo sapiens 21-25 25325880-6 2015 Associations between IL-6 and sICAM-1 and painful DSPN remained significant after additional adjustment for waist circumference, height, hypertension, cholesterol, smoking, alcohol intake, physical activity, history of myocardial infarction and/or stroke, presence of other neurological conditions, and use of nonsteroidal anti-inflammatory drugs (P = 0.005 and P = 0.016, respectively). Alcohols 173-180 interleukin 6 Homo sapiens 21-25 26637695-3 2015 Functional iron deficiency, mediated principally by the interaction of interleukin-6, the iron regulatory hormone hepcidin, and the iron exporter ferroportin, is a major contributor to the anemia of chronic disease. Iron 11-15 interleukin 6 Homo sapiens 71-84 25312962-6 2015 NaHS treatment reduced both spontaneous and IL-1beta-induced secretion of IL-6, IL-8 and RANTES in different experimental settings. sodium bisulfide 0-4 interleukin 6 Homo sapiens 74-78 25115708-9 2015 Sox9 was only involved in the proliferation increased by ATP, and Sox2 influenced the release of IL-6 stimulated by ATP. Adenosine Triphosphate 116-119 interleukin 6 Homo sapiens 97-101 25653476-9 2015 Furthermore, rapamycin decreased PA-induced nuclear translocation of NFkappaB P65 subunit, thereby NFkappaB-dependent inflammatory cytokines MCP-1 and IL-6 expression and secretion. Sirolimus 13-22 interleukin 6 Homo sapiens 151-155 25124896-7 2015 Moreover, Bz-ATP significantly abrogated the inhibitory effects of levobupivacaine, as concentrations of IL-1beta, tumor necrosis factor alpha, IL-6, and macrophage inflammatory protein 2 of the LPS + Levo + Bz-ATP group were significantly higher than those of the LPS + Levo group (all P < 0.05). 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate 10-16 interleukin 6 Homo sapiens 144-148 26031822-3 2015 Application of combined ozone therapy including ozonated autohemotherapy and superficial management of wounds with ozone-oxygen mixture resulted in significant decrease of IL-6, 8, 10 production and high level of bFGF on blood serum. Oxygen 121-127 interleukin 6 Homo sapiens 172-179 26114153-8 2015 The eCB 2-arachidonoylglycerol (2-AG) was significantly, positively associated with both interleukin (IL)-6 and C-reactive protein (CRP) and negatively associated with depressive symptoms. glyceryl 2-arachidonate 8-30 interleukin 6 Homo sapiens 89-107 26783382-5 2015 Addition of 40 mM NaCl significantly induced IL-6 and MCP-1 production but had no effect on IL-8 secretion. Sodium Chloride 18-22 interleukin 6 Homo sapiens 45-49 25561562-0 2015 Novel thiosemicarbazones regulate the signal transducer and activator of transcription 3 (STAT3) pathway: inhibition of constitutive and interleukin 6-induced activation by iron depletion. Iron 173-177 interleukin 6 Homo sapiens 137-150 26114153-8 2015 The eCB 2-arachidonoylglycerol (2-AG) was significantly, positively associated with both interleukin (IL)-6 and C-reactive protein (CRP) and negatively associated with depressive symptoms. glyceryl 2-arachidonate 32-36 interleukin 6 Homo sapiens 89-107 26263423-7 2015 An inverse association was observed between CSF folate and CSF levels of IL-6 (P <= 0.05). Folic Acid 48-54 interleukin 6 Homo sapiens 73-77 26652669-5 2015 Rapamycin treatment induced the upregulation of cytokine genes, including those from the Interleukin (IL)-6 signaling network, such as IL-8 and the Leukemia Inhibitory Factor (LIF), while quiescent fibroblasts demonstrated up-regulation of genes involved in the complement and coagulation cascade. Sirolimus 0-9 interleukin 6 Homo sapiens 89-107 24497597-10 2015 After adjustment for age, gender, mean arterial pressure, log intact parathyroid hormone, and log IL-6, log 8-isoprostane was independently associated with log klotho (beta = -0.158, p = 0.040). 8-epi-prostaglandin F2alpha 108-121 interleukin 6 Homo sapiens 98-102 25468541-6 2015 RESULTS: Pre-exposure to n-3 PUFAs as individual fatty acids results in reduced placental IL-6 production (P < 0.05), whereas exposure to complex fatty acid mixtures enriched in n-3 PUFAs (high n-3:n-6 ratios) results in a significant stimulation of IL-6 production (P < 0.05). Fatty Acids 49-60 interleukin 6 Homo sapiens 90-94 25030185-7 2015 RESULTS: After exposure to hydrogen peroxide, IL-6 secretion decreased by 35-39% when ARPE-19 cells were pre-treated with rhHsp70. Hydrogen Peroxide 27-44 interleukin 6 Homo sapiens 46-50 25468541-6 2015 RESULTS: Pre-exposure to n-3 PUFAs as individual fatty acids results in reduced placental IL-6 production (P < 0.05), whereas exposure to complex fatty acid mixtures enriched in n-3 PUFAs (high n-3:n-6 ratios) results in a significant stimulation of IL-6 production (P < 0.05). Fatty Acids 49-59 interleukin 6 Homo sapiens 90-94 26124839-6 2015 ATRA pretreatment increased interleukin-6 (IL-6) secretion of MSCs. Tretinoin 0-4 interleukin 6 Homo sapiens 28-41 25449712-12 2015 DISCUSSION: Our results suggest that the IL-6 and CRP contribute to impaired anisotropy of water diffusion in selected pathways that have been previously associated with schizophrenia suggesting differential susceptibility of selected neural pathways to immune mediators. Water 91-96 interleukin 6 Homo sapiens 41-45 26124839-6 2015 ATRA pretreatment increased interleukin-6 (IL-6) secretion of MSCs. Tretinoin 0-4 interleukin 6 Homo sapiens 43-47 25281570-7 2014 The results demonstrated that, compared with controls, 24-h pretreatment with TNF-alpha, IL-6, or endothelin-1 increased reactivity and Ca(2+) sensitivity of HPAs as revealed by agonist challenges with 80 mM KCl, 1 muM serotonin (5-hydroxytryptamine), 30 nM U-46619, and 1 muM phorbol 12,13-dibutyrate. Serotonin 219-228 interleukin 6 Homo sapiens 89-93 27167911-10 2015 Both glucose and nLDL increased IL-6 levels in a dose-dependent manner at 6 and 24 h. In conclusion, glucose treatment on HMEC-1 cells exerted a mild stimulus on NO and IL-6 production. Glucose 5-12 interleukin 6 Homo sapiens 32-36 26214881-8 2015 Qige powder ethanol extract could reduce endothelial cells secreting VEGF and IL-6 while increase Eca-9706 cells secreting. Ethanol 12-19 interleukin 6 Homo sapiens 78-82 26214881-9 2015 CONCLUSION: Qige powder ethanol extract can inhibit angiogenesis, endothelial cell proliferation, and tube formation induced by Eca-9706 cells, while reduce VEGF and IL-6 secretion of endothelial cells. Ethanol 24-31 interleukin 6 Homo sapiens 166-170 25548514-0 2014 Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway. Cisplatin 42-51 interleukin 6 Homo sapiens 180-184 25281570-7 2014 The results demonstrated that, compared with controls, 24-h pretreatment with TNF-alpha, IL-6, or endothelin-1 increased reactivity and Ca(2+) sensitivity of HPAs as revealed by agonist challenges with 80 mM KCl, 1 muM serotonin (5-hydroxytryptamine), 30 nM U-46619, and 1 muM phorbol 12,13-dibutyrate. Serotonin 230-249 interleukin 6 Homo sapiens 89-93 27167911-10 2015 Both glucose and nLDL increased IL-6 levels in a dose-dependent manner at 6 and 24 h. In conclusion, glucose treatment on HMEC-1 cells exerted a mild stimulus on NO and IL-6 production. Glucose 5-12 interleukin 6 Homo sapiens 169-173 27167911-10 2015 Both glucose and nLDL increased IL-6 levels in a dose-dependent manner at 6 and 24 h. In conclusion, glucose treatment on HMEC-1 cells exerted a mild stimulus on NO and IL-6 production. Glucose 101-108 interleukin 6 Homo sapiens 32-36 27167911-10 2015 Both glucose and nLDL increased IL-6 levels in a dose-dependent manner at 6 and 24 h. In conclusion, glucose treatment on HMEC-1 cells exerted a mild stimulus on NO and IL-6 production. Glucose 101-108 interleukin 6 Homo sapiens 169-173 25485543-8 2014 Plasma levels of IL-6 were positively related to sCD14 and serum creatinine. Creatinine 65-75 interleukin 6 Homo sapiens 17-21 24956549-8 2014 The MNC-derived TNF-alpha and IL-6 responses from MNCs were negatively correlated with insulin sensitivity (P < .03) and positively correlated with testosterone (P < .03) and androstenedione (P < .006) for the combined groups. Testosterone 151-163 interleukin 6 Homo sapiens 30-34 25150534-4 2014 RESULTS: High concentrations of glucose increased the production of pro-inflammatory cytokines interleukin-1 beta (IL-1beta), tumour necrosis factor alpha (TNF-alpha), Interleukin-6 (IL-6) at both mRNA and protein levels, and receptor activator of NF-kB ligand (RANKL) at mRNA levels in hPDL cells. Glucose 32-39 interleukin 6 Homo sapiens 168-181 25150534-4 2014 RESULTS: High concentrations of glucose increased the production of pro-inflammatory cytokines interleukin-1 beta (IL-1beta), tumour necrosis factor alpha (TNF-alpha), Interleukin-6 (IL-6) at both mRNA and protein levels, and receptor activator of NF-kB ligand (RANKL) at mRNA levels in hPDL cells. Glucose 32-39 interleukin 6 Homo sapiens 183-187 25559834-8 2014 RESULTS: Interleukin 6 levels were significantly higher in propofol than in sevoflurane group (P=0.014). Sevoflurane 76-87 interleukin 6 Homo sapiens 9-22 24644198-6 2014 RESULTS: Methadone, oxycodone and diamorphine inhibited the production of IL-6 by IL-2 stimulated PBMCs. Methadone 9-18 interleukin 6 Homo sapiens 74-78 24644198-6 2014 RESULTS: Methadone, oxycodone and diamorphine inhibited the production of IL-6 by IL-2 stimulated PBMCs. Oxycodone 20-29 interleukin 6 Homo sapiens 74-78 25369444-9 2014 The median decrease in the high-sensitivity C-reactive protein and interleukin-6 levels was significantly greater in the atorvastatin reload group (P<0.001). Atorvastatin 121-133 interleukin 6 Homo sapiens 67-80 25310360-7 2014 A low dose of curcumin (10 or 20 microM) attenuated both the macrophage cell growth inhibition and the increase in the expression of IL-6 and TNF-alpha induced by P19. Curcumin 14-22 interleukin 6 Homo sapiens 133-137 25215557-7 2014 This was also the case for serum IL-6, such that calcium (-2 +- 1 pg/mL, P < .001) and vitamin D alone (-4 +- 1 pg/mL, P < .001) and their combination (-4 +- 1 pg/mL, P < .001) led to significant reductions compared with placebo (3 +- 1 pg/mL). Calcium 49-56 interleukin 6 Homo sapiens 33-37 25215557-10 2014 CONCLUSION: Joint calcium-vitamin D supplementation might improve systemic inflammation through decreasing IL-6 and TNF-alpha concentrations in vitamin D-insufficient people with type 2 diabetes. Calcium 18-25 interleukin 6 Homo sapiens 107-111 25215557-10 2014 CONCLUSION: Joint calcium-vitamin D supplementation might improve systemic inflammation through decreasing IL-6 and TNF-alpha concentrations in vitamin D-insufficient people with type 2 diabetes. Vitamin D 26-35 interleukin 6 Homo sapiens 107-111 25215557-10 2014 CONCLUSION: Joint calcium-vitamin D supplementation might improve systemic inflammation through decreasing IL-6 and TNF-alpha concentrations in vitamin D-insufficient people with type 2 diabetes. Vitamin D 144-153 interleukin 6 Homo sapiens 107-111 25079398-9 2014 A stepwise linear regression model using all salivary biomarkers demonstrated that, at baseline, increased IL-1ra (P = 0.004) and IL-6 (P = 0.009) were significantly associated with change in PDs during SIBO. Palladium 192-195 interleukin 6 Homo sapiens 130-134 25231749-0 2014 Gossypol induces apoptosis in multiple myeloma cells by inhibition of interleukin-6 signaling and Bcl-2/Mcl-1 pathway. Gossypol 0-8 interleukin 6 Homo sapiens 70-83 25231749-10 2014 Interestingly, phosphorylation of JAK2, STAT3, ERK1/2 and p38MAPK was inhibited by Gos-treatment, indicating that Gos globally suppressed interleukin-6 (IL-6) signals. Gossypol 83-86 interleukin 6 Homo sapiens 138-151 25231749-10 2014 Interestingly, phosphorylation of JAK2, STAT3, ERK1/2 and p38MAPK was inhibited by Gos-treatment, indicating that Gos globally suppressed interleukin-6 (IL-6) signals. Gossypol 83-86 interleukin 6 Homo sapiens 153-157 25231749-10 2014 Interestingly, phosphorylation of JAK2, STAT3, ERK1/2 and p38MAPK was inhibited by Gos-treatment, indicating that Gos globally suppressed interleukin-6 (IL-6) signals. Gossypol 114-117 interleukin 6 Homo sapiens 138-151 25231749-10 2014 Interestingly, phosphorylation of JAK2, STAT3, ERK1/2 and p38MAPK was inhibited by Gos-treatment, indicating that Gos globally suppressed interleukin-6 (IL-6) signals. Gossypol 114-117 interleukin 6 Homo sapiens 153-157 25231749-12 2014 These results demonstrated that Gos induces apoptosis in MM cells not only through displacing BH3-only proteins from Bcl-2, but also through inhibiting IL-6 signaling, which leads to Bcl-2 dephosphorylation and Mcl-1 downregulation. Gossypol 32-35 interleukin 6 Homo sapiens 152-156 25393991-12 2014 IL-6 increased with decreasing eGFR (0.98 [0.97-1.00]/10 mL/min) and HDL-cholesterol (0.98 [0.96-0.99]/10 mg/mL). Cholesterol 73-84 interleukin 6 Homo sapiens 0-4 25240206-8 2014 We further explored vitamin D"s association with plasma IL-1beta, IL-6 and TNF-alpha. Vitamin D 20-29 interleukin 6 Homo sapiens 66-70 25240206-12 2014 Low vitamin D levels were associated with higher levels of the inflammatory cytokines IL-6 and IL-1beta in the blood. Vitamin D 4-13 interleukin 6 Homo sapiens 86-90 25192658-0 2014 Oroxylin A inhibits ATRA-induced IL-6 expression involved in retinoic acid syndrome by down-regulating CHOP. 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one 0-10 interleukin 6 Homo sapiens 33-37 25192658-0 2014 Oroxylin A inhibits ATRA-induced IL-6 expression involved in retinoic acid syndrome by down-regulating CHOP. Tretinoin 20-24 interleukin 6 Homo sapiens 33-37 25192658-8 2014 Our results showed that oroxylin A decreased the level of IL-6 secretion of NB4 cells with or without ATRA treatment while the effect was eliminated by C/EBPbeta siRNA. 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one 24-34 interleukin 6 Homo sapiens 58-62 25192658-8 2014 Our results showed that oroxylin A decreased the level of IL-6 secretion of NB4 cells with or without ATRA treatment while the effect was eliminated by C/EBPbeta siRNA. Tretinoin 102-106 interleukin 6 Homo sapiens 58-62 25192658-9 2014 We conclude that oroxylin A possessed abilities of inhibiting the ATRA-induced IL-6 production via modulation of LAP/LIP/CHOP in leukemia cell lines, which could providing a therapeutic strategy for RAS. 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one 17-27 interleukin 6 Homo sapiens 79-83 25192658-9 2014 We conclude that oroxylin A possessed abilities of inhibiting the ATRA-induced IL-6 production via modulation of LAP/LIP/CHOP in leukemia cell lines, which could providing a therapeutic strategy for RAS. Tretinoin 66-70 interleukin 6 Homo sapiens 79-83 25243720-2 2014 As the influence of N-glycosylation on the in vivo activities of IL-6 could not be elucidated so far, a semisynthesis of homogeneous glycoforms of IL-6 was established by sequential native chemical ligation. Nitrogen 20-21 interleukin 6 Homo sapiens 147-151 25243720-3 2014 The four cysteines of IL-6 are convenient for ligations and require only the short synthetic glycopeptide 43-48. Cysteine 9-18 interleukin 6 Homo sapiens 22-26 25296978-7 2014 Gene expression and protein profiling revealed the critical roles of IL6/STAT3-signaling and the unfolded protein response in the efficacy of YM155. YM 155 142-147 interleukin 6 Homo sapiens 69-72 25393991-14 2014 CONCLUSIONS: Higher IL-6 levels were associated with older age and non-black race, higher BMI and lower HDL-cholesterol, ongoing HIV replication, low nadir CD4 counts, comorbidities and decreased renal function. Cholesterol 108-119 interleukin 6 Homo sapiens 20-24 25262503-0 2014 TNF-alpha and IL-6 serum levels: neurobiological markers of alcohol consumption in alcohol-dependent patients? Alcohols 60-67 interleukin 6 Homo sapiens 14-18 25374757-0 2014 Histamine Promotes the Release of Interleukin-6 via the H1R/p38 and NF-kappaB Pathways in Nasal Fibroblasts. Histamine 0-9 interleukin 6 Homo sapiens 34-47 25262503-2 2014 IL-6 (day 1: T = 2,593, p = 0.013; day 7: T = 2,315, p = 0.037; day 14: T = 1,650, p = 0.112) serum levels were significantly increased at the beginning of alcohol withdrawal. Alcohols 156-163 interleukin 6 Homo sapiens 0-4 25262503-5 2014 IL-6 serum levels were directly associated with alcohol consumption (r = 0.392, p = 0.047) on day 1. Alcohols 48-55 interleukin 6 Homo sapiens 0-4 25262503-6 2014 Moreover, the IL-6 serum levels were associated with alcohol craving (PACS total score day 1: r = -0.417, p = 0.022, the score of the obsessive subscale of the OCDS on day 14 [r = -0.549, p = 0.022]), depression (r = -0.507, p = 0.005), and trait anxiety (r = -0.674, p < 0.001) on day 1. Alcohols 53-60 interleukin 6 Homo sapiens 14-18 25262503-9 2014 Our results support an association between alterations in TNF-alpha and IL-6 serum levels and alcohol consumption. Alcohols 94-101 interleukin 6 Homo sapiens 72-76 25374757-1 2014 PURPOSE: Based on the close relationship between histamine and interleukin 6 (IL-6), we hypothesized that histamine may regulate the production of cytokines, such as IL-6, during allergic inflammation. Histamine 49-58 interleukin 6 Homo sapiens 63-76 25374757-11 2014 The p38 inhibitor strongly attenuated IL-6 production in histamine-stimulated nasal fibroblasts. Histamine 57-66 interleukin 6 Homo sapiens 38-42 25374757-12 2014 CONCLUSIONS: The data presented here suggest that antihistamines may be involved in the regulation of cytokines, such as IL-6, due to the role of histamine as an inflammatory mediator in nasal fibroblasts. Histamine 54-63 interleukin 6 Homo sapiens 121-125 25374757-1 2014 PURPOSE: Based on the close relationship between histamine and interleukin 6 (IL-6), we hypothesized that histamine may regulate the production of cytokines, such as IL-6, during allergic inflammation. Histamine 49-58 interleukin 6 Homo sapiens 78-82 25374757-1 2014 PURPOSE: Based on the close relationship between histamine and interleukin 6 (IL-6), we hypothesized that histamine may regulate the production of cytokines, such as IL-6, during allergic inflammation. Histamine 49-58 interleukin 6 Homo sapiens 166-170 25374757-1 2014 PURPOSE: Based on the close relationship between histamine and interleukin 6 (IL-6), we hypothesized that histamine may regulate the production of cytokines, such as IL-6, during allergic inflammation. Histamine 106-115 interleukin 6 Homo sapiens 63-76 25374757-1 2014 PURPOSE: Based on the close relationship between histamine and interleukin 6 (IL-6), we hypothesized that histamine may regulate the production of cytokines, such as IL-6, during allergic inflammation. Histamine 106-115 interleukin 6 Homo sapiens 78-82 25374757-1 2014 PURPOSE: Based on the close relationship between histamine and interleukin 6 (IL-6), we hypothesized that histamine may regulate the production of cytokines, such as IL-6, during allergic inflammation. Histamine 106-115 interleukin 6 Homo sapiens 166-170 25374757-2 2014 Here, we examined the role of histamine in IL-6 production and histamine receptor activity in nasal fibroblasts, along with the mechanisms underlying these effects. Histamine 30-39 interleukin 6 Homo sapiens 43-47 25374757-7 2014 RESULTS: Elevated expression was seen for all histamine receptors, with IL-6 protein levels increasing significantly following histamine stimulation. Histamine 46-55 interleukin 6 Homo sapiens 72-76 25374757-8 2014 Among the histamine-receptor specific antagonists, only the H1R antagonist significantly decreased IL-6 production in histamine-stimulated nasal fibroblasts. Histamine 10-19 interleukin 6 Homo sapiens 99-103 25437592-5 2014 Within 24 hours, 61 and 77% of the IL-6 was released into the peritoneal cavity in the LADG and ODG groups, respectively. ladg 87-91 interleukin 6 Homo sapiens 35-39 25093806-10 2014 Additionally, increased IL-6 was demonstrated to jointly enhance the tumorigenic effects of iron through enforcing cell growth. Iron 92-96 interleukin 6 Homo sapiens 24-28 25437592-6 2014 In both groups, the concentration and amount of peritoneal fluid IL-6 were significantly correlated with each other (LADG group: Spearman"s rank correlation test [rS] = 0.48, P = 0.04; ODG group: rS = 0.58, P = 0.01). ladg 117-121 interleukin 6 Homo sapiens 65-69 25437592-7 2014 The concentration and amount of IL-6 in peritoneal fluid was 2.8- and 3.6-fold higher in the ODG than in the LADG group, respectively (P < 0.01). ladg 109-113 interleukin 6 Homo sapiens 32-36 25000355-6 2014 Ingenuity Pathway Analysis software revealed the anticipated interconnectivity of TNF-alpha, IL-6, and CSF-2 in CD-New of the colon. Cadmium 112-114 interleukin 6 Homo sapiens 93-97 25165394-12 2014 Twenty-four-hour urinary isothiocyanate excretion was not associated with any of the inflammation markers overall; however, IL-6 was inversely associated with total isothiocyanate excretion in GSTM1-null/GSTT1-null individuals (beta = -0.12; 95% CI: -0.19, -0.05). isothiocyanic acid 165-179 interleukin 6 Homo sapiens 124-128 25078146-12 2014 In response to glucose ingestion, MNC-derived TNFalpha, IL-6, and IL-1beta release decreased in both normal-weight control groups but failed to suppress in either normal-weight PCOS group and in obese women regardless of PCOS status. Glucose 15-22 interleukin 6 Homo sapiens 56-60 24878329-9 2014 The expression of interleukin (IL)-6, IL-8, and monocyte chemoattractant protein-1 were significantly increased in HGECs while challenged with LPS in the context of high glucose; however, the expression inflammatory cytokines were decreased significantly, whereas TLR4 was blocked by TAK-242. Glucose 170-177 interleukin 6 Homo sapiens 18-36 25350595-11 2014 RESULTS: The concentration of interleukin-6 increased with the application of melatonin without statistically significance (361.32 +- 235.22 pg/ml vs 262.58 +- 233.92 pg/ml). Melatonin 78-87 interleukin 6 Homo sapiens 30-43 25366738-3 2014 H2O2 significantly promoted HUVEC injury, whereas ultrafiltered XMJ extract significantly improved the morphological changes in injured HUVECs, increased their activity, and decreased NHE1 gene and protein expression, as well as limited the decrease in membrane permeability and expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1, interleukin (IL)-1, IL-6, and nuclear factor-kB. 4-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE 64-67 interleukin 6 Homo sapiens 383-387 25279183-10 2014 As serum iron and hepcidin-25 were both significantly increased and IL-6 was significantly decreased, with no significant changes in sTfR, it appears that the elevation of serum iron during chemotherapy may be secondary to reduced iron consumption by erythropoiesis, leading to increased expression of hepcidin-25 and suppression of Il-6 via negative feedback. Iron 178-182 interleukin 6 Homo sapiens 333-337 25279183-10 2014 As serum iron and hepcidin-25 were both significantly increased and IL-6 was significantly decreased, with no significant changes in sTfR, it appears that the elevation of serum iron during chemotherapy may be secondary to reduced iron consumption by erythropoiesis, leading to increased expression of hepcidin-25 and suppression of Il-6 via negative feedback. Iron 178-182 interleukin 6 Homo sapiens 333-337 25340554-0 2014 The inhibition of N-glycosylation of glycoprotein 130 molecule abolishes STAT3 activation by IL-6 family cytokines in cultured cardiac myocytes. Nitrogen 18-19 interleukin 6 Homo sapiens 93-97 25280408-11 2014 CONCLUSION: Carbohydrate or glutamine supplementation shifts the T helper (Th)1/Th2 balance toward Th1 responses after exercise at a simulated altitude of 4500 m. The nutritional strategies increased in IL-6, suggesting an important anti-inflammatory effect. Carbohydrates 12-24 interleukin 6 Homo sapiens 203-207 25522414-8 2014 Unexpectedly, sertraline and DHA had pro-inflammatory effects, with sertraline increasing IFN-alpha and IL-6 and DHA increasing IL-15, IL-1RA, IFN-alpha, and IL-6, though these changes were also associated with a decrease in NF-kB activity, suggesting distinct modes of action. Sertraline 68-78 interleukin 6 Homo sapiens 104-108 24995667-5 2014 RESULTS: Alcohol-use disorders patients with a positive history of MD had higher levels of the inflammatory cytokines IL-6 (P = 0.019), TNF (P = 0.020), and IFN-gamma (P = 0.001), but not of IL-10 (P = 0.853). Alcohols 9-16 interleukin 6 Homo sapiens 118-122 25029675-9 2014 Interleukin-6 increased at both post and 1h compared with pre (p < 0.05) with no differences between conditions. Hydrogen 41-43 interleukin 6 Homo sapiens 0-13 24590680-9 2014 Serum IL-6, key factor in inflammatory and iron homeostasis disorders, was detected at enrolment and after therapy at delivery. Iron 43-47 interleukin 6 Homo sapiens 6-10 25046000-5 2014 When delivered in combination with doxorubicin, one of the drugs, vincristine, was also capable of synergistically activating the NLRP3-dependent inflammasome and increasing expression of IL-1beta, IL-6, and CXCL1. Doxorubicin 35-46 interleukin 6 Homo sapiens 198-202 25046000-7 2014 Three small-molecule inhibitors known to suppress activity of kinases situated upstream of mitogen-activated kinases (MAPKs) inhibited the expression of IL-1beta, IL-6, and CXCL1 when doxorubicin and vincristine were used singly or together, so specific kinase inhibitors may be useful in reducing inflammation in patients receiving chemotherapy. Doxorubicin 184-195 interleukin 6 Homo sapiens 163-167 24965369-0 2014 Increased expression of dopamine receptors in synovial fibroblasts from patients with rheumatoid arthritis: inhibitory effects of dopamine on interleukin-8 and interleukin-6. Dopamine 24-32 interleukin 6 Homo sapiens 160-173 24702712-0 2014 Interleukin-6 in combination with the interleukin-6 receptor stimulates glucose uptake in resting human skeletal muscle independently of insulin action. Glucose 72-79 interleukin 6 Homo sapiens 0-13 24947356-0 2014 GLP-1 secretion is increased by inflammatory stimuli in an IL-6-dependent manner, leading to hyperinsulinemia and blood glucose lowering. Glucose 120-127 interleukin 6 Homo sapiens 59-63 24702712-1 2014 AIM: To examine if the physiological concentrations of both interleukin-6 (IL-6), in combination with IL-6 receptor (IL-6R), are able to stimulate glucose uptake in human skeletal muscle and to identify the associated signalling pathways. Glucose 147-154 interleukin 6 Homo sapiens 60-73 24702712-1 2014 AIM: To examine if the physiological concentrations of both interleukin-6 (IL-6), in combination with IL-6 receptor (IL-6R), are able to stimulate glucose uptake in human skeletal muscle and to identify the associated signalling pathways. Glucose 147-154 interleukin 6 Homo sapiens 75-79 24702712-6 2014 IL-6 did not stimulate glucose uptake but combined with IL-6R, induced 1.5-fold increase in glucose uptake (p < 0.05) and phosphorylation of AMPK (0.95 +- 0.19; phosphorylated: total, p < 0.05). Glucose 92-99 interleukin 6 Homo sapiens 0-4 24702712-7 2014 CONCLUSIONS: IL-6 in combination with IL-6R and not IL-6 alone increased glucose uptake in human skeletal muscle. Glucose 73-80 interleukin 6 Homo sapiens 13-17 24702712-7 2014 CONCLUSIONS: IL-6 in combination with IL-6R and not IL-6 alone increased glucose uptake in human skeletal muscle. Glucose 73-80 interleukin 6 Homo sapiens 38-42 24702712-8 2014 IL-6/IL-6R-mediated glucose uptake occurred independently of PKB/Akt phosphorylation, showing that IL-6/IL-6R-induced glucose uptake is dependent on a divergent pathway. Glucose 20-27 interleukin 6 Homo sapiens 0-4 24702712-8 2014 IL-6/IL-6R-mediated glucose uptake occurred independently of PKB/Akt phosphorylation, showing that IL-6/IL-6R-induced glucose uptake is dependent on a divergent pathway. Glucose 20-27 interleukin 6 Homo sapiens 5-9 24702712-8 2014 IL-6/IL-6R-mediated glucose uptake occurred independently of PKB/Akt phosphorylation, showing that IL-6/IL-6R-induced glucose uptake is dependent on a divergent pathway. Glucose 118-125 interleukin 6 Homo sapiens 0-4 24702712-8 2014 IL-6/IL-6R-mediated glucose uptake occurred independently of PKB/Akt phosphorylation, showing that IL-6/IL-6R-induced glucose uptake is dependent on a divergent pathway. Glucose 118-125 interleukin 6 Homo sapiens 5-9 24970861-11 2014 We show evidence of constitutive activation of the IL-6/STAT3 signaling pathway in the tumor, including TAMs, and in APCs in the spleen. Tamoxifen 104-108 interleukin 6 Homo sapiens 51-55 25517270-12 2014 CONCLUSION: In our study, vitamin D deficiency was more prevalent in patients with SLE and was associated with higher levels of IL-6 and hematuria. Vitamin D 26-35 interleukin 6 Homo sapiens 128-132 24120915-6 2014 Treatment with TNFalpha and IL-6 led to decreased expression of the vitamin D activating enzyme CYP27B1. Vitamin D 68-77 interleukin 6 Homo sapiens 28-32 25080538-5 2014 A higher intake of carbohydrates during puberty (P-trend = 0.005), particularly from higher-GI food sources (P-trend = 0.01), was prospectively related to higher concentrations of IL-6 in younger adulthood, independently of baseline BMI and early life, socioeconomic, and other nutritional factors. Carbohydrates 19-32 interleukin 6 Homo sapiens 180-184 25080538-9 2014 During puberty, a higher intake of carbohydrates from higher-GI food sources and lower whole-grain consumption prospectively predict greater IL-6 concentrations in young adulthood. Carbohydrates 35-48 interleukin 6 Homo sapiens 141-145 25080538-0 2014 Increased intake of carbohydrates from sources with a higher glycemic index and lower consumption of whole grains during puberty are prospectively associated with higher IL-6 concentrations in younger adulthood among healthy individuals. Carbohydrates 20-33 interleukin 6 Homo sapiens 170-174 24796977-0 2014 Effects of carbohydrate ingestion on acute leukocyte, cortisol, and interleukin-6 response in high-intensity long-distance running. Carbohydrates 11-23 interleukin 6 Homo sapiens 68-81 25272046-0 2014 Long-term aerobic exercise protects against cisplatin-induced nephrotoxicity by modulating the expression of IL-6 and HO-1. Cisplatin 44-53 interleukin 6 Homo sapiens 109-113 25338584-2 2014 The doxorubicin RPMI 8226 cell line (RPMI8226/DOX) was established by culturing 8226 cells with continuous low concentration and intermittent gradually-increasing-concentration of doxorubicin in vitro, the mRNA expression of Notch2,Jagged1, Jagged2, HES1 were measured by RT-PCR and the P-170 protein expression was detected by Western blot in RPMI 8226 cell line; the changes of IL-6 and VEGF were tested by ELISA. Doxorubicin 4-15 interleukin 6 Homo sapiens 380-384 25338584-5 2014 The level of VEGF and IL-6 in culture supernatants of RPMI8226/DOX was higher than that in RPMI 8226. Doxorubicin 63-66 interleukin 6 Homo sapiens 22-26 25238263-6 2014 IL-6 stimulated reactive oxygen species, arginase 1 and p-STAT3 in MDSCs. Reactive Oxygen Species 16-39 interleukin 6 Homo sapiens 0-4 25244293-6 2014 We found that nicotine-free e-liquid promoted IL-6 production and HRV infection. Nicotine 14-22 interleukin 6 Homo sapiens 46-50 25243587-5 2014 Activation of P2Y6 receptor by its natural ligand, UDP, or its specific agonist, MRS 2693, led to the production of two proinflammatory cytokines, interleukin (IL)-6 and IL-8. Uridine Diphosphate 51-54 interleukin 6 Homo sapiens 147-165 25246769-6 2014 NaHS pretreatment significantly reduced the levels of interleukin-6 and tumor necrosis factor-alpha compared with those of the Con A group. sodium bisulfide 0-4 interleukin 6 Homo sapiens 54-99 24690561-2 2014 To construct a sensing electrode, TiO2/CdS hybrid was prepared by successive adsorption and reaction of Cd(2+) and S(2-) ions on the surface of TiO2 and then was employed as matrix for immobilization of anti-IL-6 antibody, whereas CdSe QDs linked to IL-6 were used for signal amplification via the specific antibody-antigen immunoreaction between anti-IL-6 and IL-6-CdSe bioconjugate. Cadmium 39-41 interleukin 6 Homo sapiens 208-212 24690561-2 2014 To construct a sensing electrode, TiO2/CdS hybrid was prepared by successive adsorption and reaction of Cd(2+) and S(2-) ions on the surface of TiO2 and then was employed as matrix for immobilization of anti-IL-6 antibody, whereas CdSe QDs linked to IL-6 were used for signal amplification via the specific antibody-antigen immunoreaction between anti-IL-6 and IL-6-CdSe bioconjugate. Cadmium 39-41 interleukin 6 Homo sapiens 250-254 24690561-2 2014 To construct a sensing electrode, TiO2/CdS hybrid was prepared by successive adsorption and reaction of Cd(2+) and S(2-) ions on the surface of TiO2 and then was employed as matrix for immobilization of anti-IL-6 antibody, whereas CdSe QDs linked to IL-6 were used for signal amplification via the specific antibody-antigen immunoreaction between anti-IL-6 and IL-6-CdSe bioconjugate. Cadmium 39-41 interleukin 6 Homo sapiens 250-254 24690561-2 2014 To construct a sensing electrode, TiO2/CdS hybrid was prepared by successive adsorption and reaction of Cd(2+) and S(2-) ions on the surface of TiO2 and then was employed as matrix for immobilization of anti-IL-6 antibody, whereas CdSe QDs linked to IL-6 were used for signal amplification via the specific antibody-antigen immunoreaction between anti-IL-6 and IL-6-CdSe bioconjugate. Cadmium 39-41 interleukin 6 Homo sapiens 250-254 25038103-7 2014 The resting levels of IL-6, IL-10, and TNF-alpha after the exercise training in SLE reached HC levels (P > 0.05). Hydrocortisone 92-94 interleukin 6 Homo sapiens 22-26 25414773-10 2014 Taken together, the inhibitory effects of resveratrol on IL-6- and/or DHT-induced AR transcriptional activity in LNCaP prostate cancer cells are partly mediated through the suppression of STAT3 reporter gene activity, suggesting that resveratrol may be a promising therapeutic choice for the treatment of prostate cancer. Resveratrol 42-53 interleukin 6 Homo sapiens 57-62 25229003-0 2014 Prostaglandin E2 Induces IL-6 and IL-8 Production by the EP Receptors/Akt/NF-kappaB Pathways in Nasal Polyp-Derived Fibroblasts. Dinoprostone 0-16 interleukin 6 Homo sapiens 25-29 25229003-1 2014 PURPOSE: Interleukin 6 (IL-6) and IL-8 participate in the pathogenesis of chronic rhinosinusitis with nasal polyps, and their levels are increased by prostaglandin E2 (PGE2) in different cell types. Dinoprostone 150-166 interleukin 6 Homo sapiens 9-22 25229003-1 2014 PURPOSE: Interleukin 6 (IL-6) and IL-8 participate in the pathogenesis of chronic rhinosinusitis with nasal polyps, and their levels are increased by prostaglandin E2 (PGE2) in different cell types. Dinoprostone 150-166 interleukin 6 Homo sapiens 24-28 25229003-1 2014 PURPOSE: Interleukin 6 (IL-6) and IL-8 participate in the pathogenesis of chronic rhinosinusitis with nasal polyps, and their levels are increased by prostaglandin E2 (PGE2) in different cell types. Dinoprostone 168-172 interleukin 6 Homo sapiens 9-22 25229003-1 2014 PURPOSE: Interleukin 6 (IL-6) and IL-8 participate in the pathogenesis of chronic rhinosinusitis with nasal polyps, and their levels are increased by prostaglandin E2 (PGE2) in different cell types. Dinoprostone 168-172 interleukin 6 Homo sapiens 24-28 25229003-2 2014 The purposes of this study were to determine whether PGE2 has any effect on the increase in the levels of IL-6 and IL-8 in nasal polyp-derived fibroblasts (NPDFs) and subsequently investigate the possible mechanism of this effect. Dinoprostone 53-57 interleukin 6 Homo sapiens 106-110 25229003-5 2014 To determine the signaling pathway for the expression of PGE2-induced IL-6 and IL-8, PGE2 was treated with Akt and NF-kappaB inhibitors in NPDFs. Dinoprostone 57-61 interleukin 6 Homo sapiens 70-74 25229003-5 2014 To determine the signaling pathway for the expression of PGE2-induced IL-6 and IL-8, PGE2 was treated with Akt and NF-kappaB inhibitors in NPDFs. Dinoprostone 85-89 interleukin 6 Homo sapiens 70-74 25229003-9 2014 RESULTS: PGE2 significantly increased the mRNA and protein expression levels of IL-6 and IL-8 in NPDFs. Dinoprostone 9-13 interleukin 6 Homo sapiens 80-84 25229003-12 2014 The Akt and NF-kappaB inhibitors significantly blocked PGE2-induced expression of IL-6 and IL-8. Dinoprostone 55-59 interleukin 6 Homo sapiens 82-86 25229003-13 2014 CONCLUSIONS: PGE2 increases IL-6 expression via EP2 and EP4 receptors, and IL-8 expression via the EP4 receptor in NPDFs. Dinoprostone 13-17 interleukin 6 Homo sapiens 28-32 25229003-15 2014 These results suggest that signaling pathway for IL-6 and IL-8 expression induced by PGE2 might be a useful therapeutic target for the treatment of nasal polyposis. Dinoprostone 85-89 interleukin 6 Homo sapiens 49-53 25414773-0 2014 Resveratrol Inhibits IL-6-Induced Transcriptional Activity of AR and STAT3 in Human Prostate Cancer LNCaP-FGC Cells. Resveratrol 0-11 interleukin 6 Homo sapiens 21-25 25414773-4 2014 In the present study, we examined the effect of resveratrol, a phytoalexin present in grapes, on the reporter gene activity of AR and STAT3 in human prostate cancer (LNCaP-FGC) cells stimulated with interleukin-6 (IL-6) and/or dihydrotestosterone (DHT). Resveratrol 48-59 interleukin 6 Homo sapiens 199-212 25414773-4 2014 In the present study, we examined the effect of resveratrol, a phytoalexin present in grapes, on the reporter gene activity of AR and STAT3 in human prostate cancer (LNCaP-FGC) cells stimulated with interleukin-6 (IL-6) and/or dihydrotestosterone (DHT). Resveratrol 48-59 interleukin 6 Homo sapiens 214-218 25414773-7 2014 Resveratrol significantly attenuated IL-6-induced STAT3 transcriptional activity, and DHT- or IL-6-induced AR transcriptional activity. Resveratrol 0-11 interleukin 6 Homo sapiens 37-41 24877691-6 2014 ZO-NP was found to inhibit the productions and mRNA expressions of inflammatory cytokines such as interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha on the phorbol 12-myristate 13-acetate plus A23187 (PMACI)-stimulated human mast cell line, HMC-1 cells. Tetradecanoylphorbol Acetate 167-198 interleukin 6 Homo sapiens 122-159 25128825-3 2014 Treatment with BPA increased pro-inflammation cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) production, but decreased anti-inflammation cytokines interleukin-10 (IL-10) and transforming growth factor-beta (TGF-beta) production in THP1 macrophages, as well as in primary human macrophages. bisphenol A 15-18 interleukin 6 Homo sapiens 100-113 25128825-3 2014 Treatment with BPA increased pro-inflammation cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) production, but decreased anti-inflammation cytokines interleukin-10 (IL-10) and transforming growth factor-beta (TGF-beta) production in THP1 macrophages, as well as in primary human macrophages. bisphenol A 15-18 interleukin 6 Homo sapiens 115-119 25362806-5 2014 This study examined the impact of the plant composition for ethanol-water extract on human skin fibroblasts (HSF) culture. Ethanol 60-67 interleukin 6 Homo sapiens 109-112 25414773-9 2014 Furthermore, the production of prostate-specific antigen (PSA) was decreased by resveratrol in the DHT-, IL-6- or DHT plus IL-6-treated LNCaP-FGC cells. Resveratrol 80-91 interleukin 6 Homo sapiens 105-109 25414773-9 2014 Furthermore, the production of prostate-specific antigen (PSA) was decreased by resveratrol in the DHT-, IL-6- or DHT plus IL-6-treated LNCaP-FGC cells. Resveratrol 80-91 interleukin 6 Homo sapiens 123-127 25414773-10 2014 Taken together, the inhibitory effects of resveratrol on IL-6- and/or DHT-induced AR transcriptional activity in LNCaP prostate cancer cells are partly mediated through the suppression of STAT3 reporter gene activity, suggesting that resveratrol may be a promising therapeutic choice for the treatment of prostate cancer. Resveratrol 234-245 interleukin 6 Homo sapiens 57-62 24980968-9 2014 Iron chelation by excess Ent or Ybt significantly increased Lcn2-induced secretion of IL-8, IL-6, and CCL20. Iron 0-4 interleukin 6 Homo sapiens 92-96 24988892-5 2014 Most importantly, lung cancer cells themselves upregulated IL-6 secretion by activating the p38/NF-kappaB pathway through treatment with cisplatin and camptothecin. Cisplatin 137-146 interleukin 6 Homo sapiens 59-63 25103574-7 2014 The enrichment of H3K4me2 marks was 11-137 % greater in riboflavin-deficient cells compared with sufficient cells in exon 1 of genes coding for the pro-inflammatory cytokines interleukin (IL)-1alpha, IL-1beta, IL-6, and tumor necrosis factor-alpha. Riboflavin 56-66 interleukin 6 Homo sapiens 210-214 24975660-6 2014 RESULTS: We found a significant reduction of IL-1beta induced PGE2, 8-iso-PGF2beta and IL-6 chondrocytes by 5-HT(3)RA especially by dolasetron. dolasetron 132-142 interleukin 6 Homo sapiens 87-91 25237168-8 2014 With dexamethasone, upregulation of PGE2, IL-6 and IL-8 was suppressed. Dexamethasone 5-18 interleukin 6 Homo sapiens 42-46 24998635-7 2014 We found that curcumin decreased the release of IL-6 and reduced MMP-9 enzyme activity. Curcumin 14-22 interleukin 6 Homo sapiens 48-52 25238834-15 2014 In conclusion, iron may stimulate the expression of pro-inflammatory genes (TNF-alpha and IL- 6), and both hepcidin and ferritin gene expression levels could be a risk factor for the development of type 2 diabetes. Iron 15-19 interleukin 6 Homo sapiens 90-95 24477600-8 2014 Moreover, adenosine inhibited thrombin-induced elevated expression of proinflammatory cytokines, IL-6 and HMGB-1; and chemokines, MCP-1, CXCL-1, and CXCL-3. Adenosine 10-19 interleukin 6 Homo sapiens 97-101 24970314-8 2014 In the present study, inflammatory cytokine interleukin 6 (IL6) and its downstream activated signal transducer and activator of transcription 3 [phospho-STAT3(tyrosine705) and phospho-STAT3(serine727)] were downregulated after tanshinone IIA treatment in vitro and in vivo. tanshinone 227-237 interleukin 6 Homo sapiens 44-57 24970314-8 2014 In the present study, inflammatory cytokine interleukin 6 (IL6) and its downstream activated signal transducer and activator of transcription 3 [phospho-STAT3(tyrosine705) and phospho-STAT3(serine727)] were downregulated after tanshinone IIA treatment in vitro and in vivo. tanshinone 227-237 interleukin 6 Homo sapiens 59-62 24970314-9 2014 This result indicated that disturbance of the IL6/STAT3 signaling axis by tanshinone IIA is closely related to the growth inhibition of GSCs. tanshinone 74-88 interleukin 6 Homo sapiens 46-49 24801617-0 2014 17beta-Estradiol inhibition of IL-6-Src and Cas and paxillin pathway suppresses human mesenchymal stem cells-mediated gastric cancer cell motility. Estradiol 0-16 interleukin 6 Homo sapiens 31-35 25164554-0 2014 IL-6 secreted by cancer-associated fibroblasts induces tamoxifen resistance in luminal breast cancer. Tamoxifen 55-64 interleukin 6 Homo sapiens 0-4 24951586-4 2014 First, silencing ASM with siRNA abrogated IL-6 production in response to the tumor promoter, 4beta-phorbol 12-myristate 13-acetate (PMA), in MCF-7 cells, in distinction to acid beta-glucosidase 1 and acid ceramidase, suggesting specialization of the pathways. Tetradecanoylphorbol Acetate 132-135 interleukin 6 Homo sapiens 42-46 25024384-6 2014 In vitro pre-exposure to moderate alcohol reduced subsequent LPS-induced NF-kappaB promoter activity and downstream TNF-alpha, IL-6 and IL-1beta production in monocytes and macrophages, exhibiting endotoxin tolerance. Alcohols 34-41 interleukin 6 Homo sapiens 127-131 25099355-4 2014 atRA prevents human nTregs from converting to Th1 and/or Th17 cells and sustains their Foxp3 expression and suppressive function in vitro or in vivo following encounters with IL-1 and IL-6. Tretinoin 0-4 interleukin 6 Homo sapiens 184-188 25099355-5 2014 Interestingly, adoptive transfer of human nTregs pretreated with atRA significantly enhanced their suppressive effects on xenograft-vs.-host diseases (xGVHDs), and atRA- but not rapamycin-pretreated nTregs sustained the functional activity against xGVHD after stimulation with IL-1/IL-6. Tretinoin 65-69 interleukin 6 Homo sapiens 282-286 24951586-4 2014 First, silencing ASM with siRNA abrogated IL-6 production in response to the tumor promoter, 4beta-phorbol 12-myristate 13-acetate (PMA), in MCF-7 cells, in distinction to acid beta-glucosidase 1 and acid ceramidase, suggesting specialization of the pathways. Tetradecanoylphorbol Acetate 93-130 interleukin 6 Homo sapiens 42-46 25125975-10 2014 Multiple regression analysis predicts that cutaneous T-cell-attracting chemokine, eotaxin, IL-6, and stem cell factor are inversely associated with forced expiratory volume in 1 second and peak oxygen uptake change, whereas smoking is related to eotaxin and hepatocyte growth factor changes. Oxygen 194-200 interleukin 6 Homo sapiens 91-95 25606437-2 2014 Some of the immune non-classical actions of vitamin D may point to its role in the pathogenesis of type 2 DM through down-regulation of cytokines (IL-6). Vitamin D 44-53 interleukin 6 Homo sapiens 147-151 25096410-0 2014 Effect of metformin on serum interleukin-6 levels in polycystic ovary syndrome: a systematic review. Metformin 10-19 interleukin 6 Homo sapiens 29-42 24880897-9 2014 However, treatment of inflammatory M1 macrophages with aspirin reduced secretion of the pro-inflammatory cytokines IL-1beta and IL-6, and increased secretion of the anti-inflammatory IL-10. Aspirin 55-62 interleukin 6 Homo sapiens 128-132 25096410-5 2014 Studies were selected that evaluated the effect of metformin on IL-6 levels in PCOS patients. Metformin 51-60 interleukin 6 Homo sapiens 64-68 25096410-8 2014 Of these, one study reported a significant decrease in IL-6 levels after metformin treatment in women with PCOS. Metformin 73-82 interleukin 6 Homo sapiens 55-59 25096410-11 2014 CONCLUSIONS: Serum IL-6 levels of PCOS patients may be influenced by metformin. Metformin 69-78 interleukin 6 Homo sapiens 19-23 25096410-13 2014 However, further investigations with larger samples are needed to better understand the effects of metformin on IL-6 levels and chronic inflammation in PCOS. Metformin 99-108 interleukin 6 Homo sapiens 112-116 25088288-4 2014 RESULTS: Curcumin reduced HCMV immediate early antigen (IEA) and UL83A expressions and IL-6, and TNF-alpha secretions and recovered cell proliferation to normal level in HCMV infected HELF cells. Curcumin 9-17 interleukin 6 Homo sapiens 87-91 24719336-11 2014 PGE2 receptor antagonists dose-dependently inhibited the release of IL-6, IL-8, and PGE2 by IFP-stimulated FLS. Dinoprostone 0-4 interleukin 6 Homo sapiens 68-72 24702172-8 2014 The rise in IL-6 from baseline to peak concentration significantly correlated inversely with blood glucose area under the curve (r=-0.65, P=0.041). Glucose 99-106 interleukin 6 Homo sapiens 12-16 24880571-9 2014 Conversely, corticosterone, prednisone, and dexamethasone similarly inhibited cell invasion and expression of related genes, including MMP-9, VEGF, and IL-6, in GR-positive lines. Dexamethasone 44-57 interleukin 6 Homo sapiens 152-156 24374727-4 2014 We used a multiplex protein assay to determine the tumor expression levels of the proangiogenic proteins IL-6, IL-8, bFGF, PDGF-BB and VEGF-A in formalin-fixed paraffin-embedded tumors from the MAX clinical trial patients with available tissue samples. Paraffin 160-168 interleukin 6 Homo sapiens 105-109 24929023-8 2014 IL-6 levels in the H2 group significantly decreased in 4 weeks by 37.3 +- 62.0% compared to baseline, whereas it increased by 33.6 +- 34.4% in the placebo group. Hydrogen 19-21 interleukin 6 Homo sapiens 0-4 24874441-3 2014 Reactive oxygen species (ROS) level was measured in monocytes and neutrophils by flow cytometry using 2,7-dichlorofluorescein diacetate (DCFH-DA) as substrate, while, tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 levels were estimated in PBMC supernatant by enzyme-linked immunosorbent assays (ELISA). Reactive Oxygen Species 0-23 interleukin 6 Homo sapiens 205-223 24970893-9 2014 On the other hand, activation of CREB with adenosine suppressed IL-6 expression. Adenosine 43-52 interleukin 6 Homo sapiens 64-68 24347287-0 2014 Activation of a positive feedback loop involving IL-6 and aromatase promotes intratumoral 17beta-estradiol biosynthesis in endometrial carcinoma microenvironment. Estradiol 90-106 interleukin 6 Homo sapiens 49-53 24607939-6 2014 Interestingly, liposomal dexamethasone induced proinflammatory cytokine secretion (specifically TNF, IL1beta, IL6) in unstimulated cells, but reduced this response under inflammatory conditions. Dexamethasone 25-38 interleukin 6 Homo sapiens 110-113 25221751-3 2014 This study was conducted to examine the association between dietary fatty acid intakes and inflammatory markers, interleukin 6 (IL-6) and high sensitivity C-reactive protein (hs-CRP), in CAD patients among Iranian population. Fatty Acids 68-78 interleukin 6 Homo sapiens 113-126 25221751-3 2014 This study was conducted to examine the association between dietary fatty acid intakes and inflammatory markers, interleukin 6 (IL-6) and high sensitivity C-reactive protein (hs-CRP), in CAD patients among Iranian population. Fatty Acids 68-78 interleukin 6 Homo sapiens 128-132 25221751-8 2014 After adjustment for potential confounders, SFA was directly related to hs-CRP (P = 0.01) and IL-6 (P < 0.001) concentrations. Fatty Acids 44-47 interleukin 6 Homo sapiens 94-98 24793913-5 2014 Nucleotides such as ATP and UTP themselves also significantly increased IL-6 production in the cells. Adenosine Triphosphate 20-23 interleukin 6 Homo sapiens 72-76 24793913-7 2014 These results support the possible role of ATP in SNP30-induced IL-6 production by HaCaT cells. Adenosine Triphosphate 43-46 interleukin 6 Homo sapiens 64-68 24347287-6 2014 When cocultured with 17beta-estradiol (E2 )-treated cancer cells, aromatase mRNA in stromal cells was significantly elevated and increased IL-6 protein levels were detected in E2 -treated culture medium. Estradiol 21-37 interleukin 6 Homo sapiens 139-143 25002027-3 2014 The mechanism involves the regulation of cellular redox through an mTORC1/c-Myc pathway of stromal glucose and amino acid metabolism, resulting in increased stromal IL-6 production, which is required for tumor promotion in the epithelial compartment. Glucose 99-106 interleukin 6 Homo sapiens 165-169 25221588-3 2014 In turn, noradrenaline may act on up-regulated alpha1-adrenoceptors to increase the production of the pro-inflammatory cytokine interleukin-6. Norepinephrine 9-22 interleukin 6 Homo sapiens 128-141 24992685-5 2014 RESULTS: In response to treatment with either TNF-alpha or IL-6 (0-100 ng/ml, 0-24 hrs), our studies consistently demonstrated significant dose- and time-dependent decreases in the expression of all interendothelial junction proteins examined, in parallel with dose- and time-dependent increases in ROS generation and HBMvEC permeability. ros 299-302 interleukin 6 Homo sapiens 59-63 24993495-8 2014 Importantly, co-injection of IL-6 with the methionine analogue azido-homoalanine (AHA), to assess nascently synthesized proteins, revealed an increase in CREB containing AHA in the sciatic nerve 2 hrs post injection, indicating retrograde transport of nascently synthesized CREB. Methionine 43-53 interleukin 6 Homo sapiens 29-33 24993495-9 2014 Behaviorally, blockade of retrograde transport by disruption of microtubules or inhibition of dynein or intrathecal injection of cAMP response element (CRE) consensus sequence DNA oligonucleotides, which act as decoys for CREB DNA binding, prevented the development of IL-6-induced mechanical hypersensitivity and hyperalgesic priming. Cyclic AMP 129-133 interleukin 6 Homo sapiens 269-273 24864079-3 2014 Promising clinical data for "upstream" biomarkers of inflammation such as interleukin-6 (IL-6) as well as "downstream" biomarkers such as C-reactive protein, observations regarding cholesterol crystals as an activator of the IL-1beta generating inflammasome, and recent Mendelian randomization data for the IL-6 receptor support the hypothesis that inflammatory mediators of atherosclerosis may converge on the central IL-1, tumour necrosis factor (TNF-alpha), IL-6 signalling pathway. Cholesterol 181-192 interleukin 6 Homo sapiens 307-311 24864079-3 2014 Promising clinical data for "upstream" biomarkers of inflammation such as interleukin-6 (IL-6) as well as "downstream" biomarkers such as C-reactive protein, observations regarding cholesterol crystals as an activator of the IL-1beta generating inflammasome, and recent Mendelian randomization data for the IL-6 receptor support the hypothesis that inflammatory mediators of atherosclerosis may converge on the central IL-1, tumour necrosis factor (TNF-alpha), IL-6 signalling pathway. Cholesterol 181-192 interleukin 6 Homo sapiens 307-311 24990982-9 2014 Melatonin treatment at a physiological concentration (10 nM) induced ASIC3 expression and IL-6 production. Melatonin 0-9 interleukin 6 Homo sapiens 90-94 24269922-2 2014 The iron regulatory hormone hepcidin is regulated by iron and cytokines interleukin (IL) 6 and IL1beta. Iron 4-8 interleukin 6 Homo sapiens 72-90 24910242-5 2014 Notably, rapamycin treatment or hepatocyte-specific ablation of the specific mTORC1 subunit Raptor resulted in elevated interleukin-6 (IL-6) production, activation of signal transducer and activator of transcription 3 (STAT3), and enhanced HCC development, despite a transient reduction in hepatosteatosis. Sirolimus 9-18 interleukin 6 Homo sapiens 120-133 24910242-5 2014 Notably, rapamycin treatment or hepatocyte-specific ablation of the specific mTORC1 subunit Raptor resulted in elevated interleukin-6 (IL-6) production, activation of signal transducer and activator of transcription 3 (STAT3), and enhanced HCC development, despite a transient reduction in hepatosteatosis. Sirolimus 9-18 interleukin 6 Homo sapiens 135-139 25091484-7 2014 Cholesterol crystal activation of the NF-kappaB pathway also leads to increased IL-6 and IL-8 expression. Cholesterol 0-11 interleukin 6 Homo sapiens 80-84 24939178-7 2014 Together, our data provide a novel explanation that high level of IL6 stimulated SOD2 expression that, at least partially, contributed to the low level of ROS that would likely result in a sustained increase in the expression of IGF-1R through abolishment of beta-arrestin1 in docetaxel resistant cells. Reactive Oxygen Species 155-158 interleukin 6 Homo sapiens 66-69 25222779-9 2014 INTERPRETATION & CONCLUSIONS: Our data suggest that IL-6 gene polymorphisms play a prominent role in T2DM disease susceptibility in population from north India. Adenosine Monophosphate 16-19 interleukin 6 Homo sapiens 56-60 24788377-8 2014 The results indicated that the levels of IL-6 in ELF were significantly increased in both the ventilated DL and collapsed NDL after OLV compared with the levels prior to OLV in the sevoflurane group. Sevoflurane 181-192 interleukin 6 Homo sapiens 41-45 24631773-6 2014 We found that following treatment with a phosphate-containing medium the level of IL-6 expressed by VICs increased by several-fold. Phosphates 41-50 interleukin 6 Homo sapiens 82-86 24652540-6 2014 When cAMP-treated monocytes are exposed to proinflammatory stimuli, they exhibit an increased production of IL-6 and IL-10 and a lower amount of TNF-alpha and IL-12 compared with control cells, resembling the features of the alternative-activated macrophages or M2 macrophages. Cyclic AMP 5-9 interleukin 6 Homo sapiens 108-112 24631773-7 2014 Phosphate-induced expression of IL-6 relied on reduced PI3K/Akt signaling downstream of the P2Y2 receptor (P2Y2R). Phosphates 0-9 interleukin 6 Homo sapiens 32-36 24631773-9 2014 In addition, by using a siRNA targeting IL-6 we found that phosphate-induced mineralization was largely dependent on IL-6 expression. Phosphates 59-68 interleukin 6 Homo sapiens 40-44 24631773-9 2014 In addition, by using a siRNA targeting IL-6 we found that phosphate-induced mineralization was largely dependent on IL-6 expression. Phosphates 59-68 interleukin 6 Homo sapiens 117-121 24854571-0 2014 Puerarin concurrently stimulates osteoprotegerin and inhibits receptor activator of NF-kappaB ligand (RANKL) and interleukin-6 production in human osteoblastic MG-63 cells. puerarin 0-8 interleukin 6 Homo sapiens 113-126 24854571-6 2014 Here we show that puerarin concurrently stimulates osteoprotegerin (OPG) and inhibits receptor activator of nuclear factor-kappaB ligand (RANKL) and Interleukin-6 (IL-6) production by human osteoblastic MG-63 cells containing two estrogen receptor (ER) isotypes. puerarin 18-26 interleukin 6 Homo sapiens 149-162 24854571-6 2014 Here we show that puerarin concurrently stimulates osteoprotegerin (OPG) and inhibits receptor activator of nuclear factor-kappaB ligand (RANKL) and Interleukin-6 (IL-6) production by human osteoblastic MG-63 cells containing two estrogen receptor (ER) isotypes. puerarin 18-26 interleukin 6 Homo sapiens 164-168 24673855-8 2014 Our data indicate that high concentrations of IL-6 during the glucose clamp may be limited to the atypical subgroup of patients with MDD. Glucose 62-69 interleukin 6 Homo sapiens 46-50 24742701-5 2014 Investigation of the molecular mechanisms underlying these effects found that interleukin 6 (IL-6) was significantly up-regulated in DOX-treated tissues and cells, and supernatant from IL-6 treated cells had a similar effect to that from DOX-treated cells. Doxorubicin 133-136 interleukin 6 Homo sapiens 78-91 24796665-4 2014 ALA pretreatment significantly reduced apoptotic cell death of the inner and outer hair cells in cisplatin-treated organ of Corti explants and attenuated ototoxicity via marked inhibition of the increase in the expression of IL-1beta and IL-6, the phosphorylation of ERK and p38, the degradation of IkappaBalpha, the increase in intracellular levels of ROS, and the activation of caspase-3 in cisplatin-treated HEI-OC1 cells. Cisplatin 97-106 interleukin 6 Homo sapiens 238-242 24742701-5 2014 Investigation of the molecular mechanisms underlying these effects found that interleukin 6 (IL-6) was significantly up-regulated in DOX-treated tissues and cells, and supernatant from IL-6 treated cells had a similar effect to that from DOX-treated cells. Doxorubicin 133-136 interleukin 6 Homo sapiens 93-97 24742701-5 2014 Investigation of the molecular mechanisms underlying these effects found that interleukin 6 (IL-6) was significantly up-regulated in DOX-treated tissues and cells, and supernatant from IL-6 treated cells had a similar effect to that from DOX-treated cells. Doxorubicin 238-241 interleukin 6 Homo sapiens 93-97 24742701-5 2014 Investigation of the molecular mechanisms underlying these effects found that interleukin 6 (IL-6) was significantly up-regulated in DOX-treated tissues and cells, and supernatant from IL-6 treated cells had a similar effect to that from DOX-treated cells. Doxorubicin 238-241 interleukin 6 Homo sapiens 185-189 24913620-8 2014 RESULTS: We demonstrated that CB2 inverse agonists SR144528 and AM630, but not CB2 agonist HU308 or CB1 antagonist SR141716, effectively inhibited IL-6-induced secretion of soluble IgM without affecting cell proliferation as measured by thymidine uptake. SR 144528 51-59 interleukin 6 Homo sapiens 147-151 24911931-6 2014 Fatty acid exposure at 2 and 4 h increased both monocyte chemoattractant protein-1 and interleukin-6 gene expression levels in preadipocytes to greater levels than in mature adipocytes. Fatty Acids 0-10 interleukin 6 Homo sapiens 87-100 24918924-5 2014 RESULTS: In HAEC, TLR4 antagonism with eritoran inhibited LPS-induced mRNA expression of IL-6, IL-8, TNFalpha, CCL-2, VCAM and ICAM (P<0.05 for all) and inhibited Ox-PAPC-induced mRNA expression of IL-8 (P<0.05) and IL-6, albeit not to a statistically significant level (p = 0.07). eritoran 39-47 interleukin 6 Homo sapiens 89-93 24918924-5 2014 RESULTS: In HAEC, TLR4 antagonism with eritoran inhibited LPS-induced mRNA expression of IL-6, IL-8, TNFalpha, CCL-2, VCAM and ICAM (P<0.05 for all) and inhibited Ox-PAPC-induced mRNA expression of IL-8 (P<0.05) and IL-6, albeit not to a statistically significant level (p = 0.07). eritoran 39-47 interleukin 6 Homo sapiens 222-226 24909173-0 2014 IL-6 secreted by cancer-associated fibroblasts induces tamoxifen resistance in luminal breast cancer. Tamoxifen 55-64 interleukin 6 Homo sapiens 0-4 24909173-6 2014 In xenograft experiments of CAFs mixed with MCF7 cells, CAF-specific IL-6 knockdown inhibited tumorigenesis and restored tamoxifen sensitivity. Tamoxifen 121-130 interleukin 6 Homo sapiens 69-73 24909173-7 2014 These findings indicate that CAFs mediate tamoxifen resistance through IL-6-induced degradation of ER-alpha in luminal BrCAs.Oncogene advance online publication, 9 June 2014; doi:10.1038/onc.2014.158. Tamoxifen 42-51 interleukin 6 Homo sapiens 71-75 24913620-10 2014 These effects were receptor mediated, as pretreatment with CB2 agonist abrogated SR144528-mediated inhibition of IL-6 stimulated IgM secretion. SR 144528 81-89 interleukin 6 Homo sapiens 113-117 24913620-11 2014 Transcription factors relevant to B cell differentiation, Bcl-6 and PAX5, as well as the protein kinase STAT3 pathway were involved in the inhibition of IL-6-induced IgM by SR144528. SR 144528 173-181 interleukin 6 Homo sapiens 153-157 24063605-9 2014 The replacement of Cys(259) residue with Ala abolished the inhibitory role of GSNO in IL-6-induced STAT3 phosphorylation and transactivation, suggesting the role of Cys(259) S-nitrosylation in STAT3 phosphorylation. Cysteine 19-22 interleukin 6 Homo sapiens 86-90 24896536-2 2014 A new study shows that modulation of macrophage activation by IL-6 maintains glucose homeostasis in diet-induced obesity while limiting inflammation in endotoxemia (Mauer et al., 2014). Glucose 77-84 interleukin 6 Homo sapiens 62-66 24499830-8 2014 The median IL-6 level increased from 0.8 to 36.3 pg/dl in the ODG group and from 1.5 to 53.3 pg/dl in the LADG group. ladg 106-110 interleukin 6 Homo sapiens 11-15 24063605-9 2014 The replacement of Cys(259) residue with Ala abolished the inhibitory role of GSNO in IL-6-induced STAT3 phosphorylation and transactivation, suggesting the role of Cys(259) S-nitrosylation in STAT3 phosphorylation. Alanine 41-44 interleukin 6 Homo sapiens 86-90 23211339-6 2014 It has been reported that most PC types and/or multicentric types of CD show increasing levels of serum IL-6 and VEGF, as well as systemic symptoms. Cadmium 69-71 interleukin 6 Homo sapiens 104-117 24063605-9 2014 The replacement of Cys(259) residue with Ala abolished the inhibitory role of GSNO in IL-6-induced STAT3 phosphorylation and transactivation, suggesting the role of Cys(259) S-nitrosylation in STAT3 phosphorylation. S-Nitrosoglutathione 78-82 interleukin 6 Homo sapiens 86-90 24063605-9 2014 The replacement of Cys(259) residue with Ala abolished the inhibitory role of GSNO in IL-6-induced STAT3 phosphorylation and transactivation, suggesting the role of Cys(259) S-nitrosylation in STAT3 phosphorylation. Cysteine 165-168 interleukin 6 Homo sapiens 86-90 24714919-6 2014 RESULTS: There was a significant inverse correlation between IL-6 levels and FMD (-0.042; p=0.02) after adjustment for age, gender, race/ethnicity, education, income, low-density lipoprotein, diabetes, glucose, hypertension status and treatment, waist circumference, triglycerides, baseline brachial diameter, recent infection and use of medications that may alter inflammation. Glucose 202-209 interleukin 6 Homo sapiens 61-65 24628003-5 2014 IL-6 levels were significantly correlated positively with BMI and triglyceride levels; however, negatively correlated with high-density lipoprotein levels. Triglycerides 66-78 interleukin 6 Homo sapiens 0-4 24714919-6 2014 RESULTS: There was a significant inverse correlation between IL-6 levels and FMD (-0.042; p=0.02) after adjustment for age, gender, race/ethnicity, education, income, low-density lipoprotein, diabetes, glucose, hypertension status and treatment, waist circumference, triglycerides, baseline brachial diameter, recent infection and use of medications that may alter inflammation. Triglycerides 267-280 interleukin 6 Homo sapiens 61-65 24617709-9 2014 In GEE analyses, higher IL-6, TNF-alpha, ESR, and CRP were associated with lower PTH concentrations (all P < .001), adjusted for corrected calcium and 25(OH)D levels. Calcium 142-149 interleukin 6 Homo sapiens 24-28 24559521-5 2014 IL-6 >= 30,750 pg/ml and lactate >= 10 mmol/l make a PJI very likely, IL-6 <10,000pg/ml or lactate <4.3 mmol/l makes a PJI very unlikely. Lactic Acid 28-35 interleukin 6 Homo sapiens 76-80 24849681-8 2014 Based on a logistic regression analysis, smoker phosphate mine workers have a higher relative risk than controls to have an increase concentration of some cytokines, especially IL-1beta, IL-6, IL-8, TNF-alpha, and MIP-1beta. Phosphates 48-57 interleukin 6 Homo sapiens 187-191 24576416-8 2014 In response to glucose ingestion, plasma IL-6 and sVCAM-1 increased and CRP suppression was attenuated in both PCOS groups and obese controls compared with lean controls. Glucose 15-22 interleukin 6 Homo sapiens 41-45 24576416-10 2014 The absolute change in plasma IL-6 correlated positively with testosterone. Testosterone 62-74 interleukin 6 Homo sapiens 30-34 24849681-9 2014 Moreover, the combined effect of smoking and phosphate dusts exposure increases the level of leucocytes as well as the concentration of IL-1beta, IL-6, IL-8, MIP1-beta, and LTB-4. Phosphates 45-54 interleukin 6 Homo sapiens 146-150 24644001-7 2014 Metformin reversed EMT and decreased IL-6 signaling activation in TKI-resistant cells, while adding IL-6 to those cells bypassed the anti-TKI-resistance effect of metformin. Metformin 163-172 interleukin 6 Homo sapiens 100-104 24752587-4 2014 Histamine can also dose-dependently stimulate microglia activation and subsequently production of proinflammatory factors tumor necrosis factor (TNF)-alpha and interleukin-6 (IL-6). Histamine 0-9 interleukin 6 Homo sapiens 160-173 24752587-4 2014 Histamine can also dose-dependently stimulate microglia activation and subsequently production of proinflammatory factors tumor necrosis factor (TNF)-alpha and interleukin-6 (IL-6). Histamine 0-9 interleukin 6 Homo sapiens 175-179 24752587-5 2014 The antagonists of H1R and H4R but not H2R and H3R reduced histamine-induced TNF-alpha and IL-6 production, MAPK and PI3K/AKT pathway activation, and mitochondrial membrane potential loss in microglia, suggesting that the actions of histamine are via H1R and H4R. Histamine 59-68 interleukin 6 Homo sapiens 91-95 24752587-6 2014 On the other hand, inhibitors of JNK, p38, or PI3K suppressed histamine-induced TNF-alpha and IL-6 release from microglia. Histamine 62-71 interleukin 6 Homo sapiens 94-98 24752587-7 2014 Histamine also activated NF-kappa B and ammonium pyrrolidinedithiocarbamate, an inhibitor of NF-kappa B, and reduced histamine-induced TNF-alpha and IL-6 release. Histamine 0-9 interleukin 6 Homo sapiens 149-153 24752587-7 2014 Histamine also activated NF-kappa B and ammonium pyrrolidinedithiocarbamate, an inhibitor of NF-kappa B, and reduced histamine-induced TNF-alpha and IL-6 release. Histamine 117-126 interleukin 6 Homo sapiens 149-153 24752587-9 2014 We also demonstrate that histamine induced TNF-alpha and IL-6 release from activated microglia via H1R and H4R-MAPK and PI3K/AKT-NF-kappa B signaling pathway, which will deepen the understanding of microglia-mediated neuroinflammatory symptoms of chronic neurodegenerative disease. Histamine 25-34 interleukin 6 Homo sapiens 57-61 24503057-3 2014 OBJECTIVE: Therefore we investigated whether LPS-induced expression of the pro-inflammatory cytokine interleukin-6 (IL-6) influences hypericin and protoporphyrin IX (PpIX) accumulation, and their photocytotoxicity. protoporphyrin IX 147-164 interleukin 6 Homo sapiens 101-114 24503057-3 2014 OBJECTIVE: Therefore we investigated whether LPS-induced expression of the pro-inflammatory cytokine interleukin-6 (IL-6) influences hypericin and protoporphyrin IX (PpIX) accumulation, and their photocytotoxicity. protoporphyrin IX 147-164 interleukin 6 Homo sapiens 116-120 24503057-3 2014 OBJECTIVE: Therefore we investigated whether LPS-induced expression of the pro-inflammatory cytokine interleukin-6 (IL-6) influences hypericin and protoporphyrin IX (PpIX) accumulation, and their photocytotoxicity. protoporphyrin IX 166-170 interleukin 6 Homo sapiens 101-114 24932134-3 2014 IL-6 receptor subunits are subject to N-glycosylation, a posttranslational modification which is important for protein stability and function. Nitrogen 38-39 interleukin 6 Homo sapiens 0-4 24361422-0 2014 Ultrasensitive multi-analyte electrochemical immunoassay based on GNR-modified heated screen-printed carbon electrodes and PS@PDA-metal labels for rapid detection of MMP-9 and IL-6. Metals 130-135 interleukin 6 Homo sapiens 176-180 24644001-0 2014 Metformin sensitizes EGFR-TKI-resistant human lung cancer cells in vitro and in vivo through inhibition of IL-6 signaling and EMT reversal. Metformin 0-9 interleukin 6 Homo sapiens 107-111 24644001-4 2014 This study aims to investigate the effect of metformin on sensitizing EGFR-TKI-resistant human lung cancer cells in vitro and in vivo through inhibition of IL-6 signaling and EMT reversal. Metformin 45-54 interleukin 6 Homo sapiens 156-160 24644001-7 2014 Metformin reversed EMT and decreased IL-6 signaling activation in TKI-resistant cells, while adding IL-6 to those cells bypassed the anti-TKI-resistance effect of metformin. Metformin 0-9 interleukin 6 Homo sapiens 37-41 24858952-12 2014 CONCLUSIONS: Heavily reducing rapid-acting insulin dose with a carbohydrate bolus before, and a meal after intensive running exercise may cause hyperglycaemia, but does not augment ketonaemia, raise inflammatory cytokines TNF-alpha and IL-6 above fasting levels, or cause other adverse metabolic or hormonal disturbances. Carbohydrates 63-75 interleukin 6 Homo sapiens 236-240 24644001-8 2014 Furthermore, overexpression or addition of IL-6 to TKI-sensitive cells induced TKI resistance, which could be overcome by metformin. Metformin 122-131 interleukin 6 Homo sapiens 43-47 24644001-9 2014 Finally, metformin-based combinatorial therapy effectively blocked tumor growth in xenografts with TKI-resistant cancer cells, which was associated with decreased IL-6 secretion and expression, EMT reversal, and decreased IL-6-signaling activation in vivo. Metformin 9-18 interleukin 6 Homo sapiens 163-167 24644001-9 2014 Finally, metformin-based combinatorial therapy effectively blocked tumor growth in xenografts with TKI-resistant cancer cells, which was associated with decreased IL-6 secretion and expression, EMT reversal, and decreased IL-6-signaling activation in vivo. Metformin 9-18 interleukin 6 Homo sapiens 222-226 24885771-6 2014 In vitro macrophage exposure to representative NP (Fe2O3, Fe3O4, MnFe2O4 and CrOOH) induced the production of a pro-inflammatory secretome (increased production of CXCL-8, IL-1ss, TNF-alpha, CCL-2, -3, -4, and to a lesser extent IL-6, CCL-7 and -22), and all but Fe3O4 NP induce an increased migration of macrophages (Boyden chamber). Iron(III) oxide 51-56 interleukin 6 Homo sapiens 229-233 24487064-2 2014 We have shown recently that heteroarylketones (HAKs) interfere with stimulated interleukin-6 expression in astrocytes by suppression of STAT3 phosphorylation at serine 727. Serine 161-167 interleukin 6 Homo sapiens 79-92 24897969-0 2014 In vitro protective effect of Celergen, a bioactive marine compound, on interleukin-6-related invasiveness of pancreatic cancer. celergen 30-38 interleukin 6 Homo sapiens 72-85 24897969-3 2014 The invasive ability of HI cells and the level of IL-6 in the conditioned medium of HI cells was significantly higher than that one of LI cells but both these parameters were significantly reduced by the addition of Celergen (p<0.01). celergen 216-224 interleukin 6 Homo sapiens 50-54 24800851-4 2014 Genkwanin potently decreases the proinflammatory mediators, such as iNOS, TNF-alpha, IL-1beta and IL-6, at the transcriptional and translational levels without cytotoxicity, indicating the excellent anti-inflammatory potency of genkwanin in vitro. genkwanin 0-9 interleukin 6 Homo sapiens 98-102 24413578-12 2014 In multivariate analysis, baseline cholesterol levels and cardiopulmonary bypass duration were significant and independent determinants of the 3-hour postcardiopulmonary bypass increase in concentrations of procalcitonin and interleukin-8, but not of interleukin-6. Cholesterol 35-46 interleukin 6 Homo sapiens 251-264 24709011-7 2014 Furthermore, flagellin-stimulated KMS28BM cells were shown to have "increased doxorubicin and apoptosis resistance" through the inhibition of caspases and PARP activity, and this result was reversed by blocking IL-6. Doxorubicin 78-89 interleukin 6 Homo sapiens 211-215 24480517-4 2014 IL-1beta and IL-6 levels in blood plasma and supernatant after ATP stimulation were measured by ELISA. Adenosine Triphosphate 63-66 interleukin 6 Homo sapiens 13-17 24521568-3 2014 Moreover, HB-COS exerted inhibitory effects on the production of pro-inflammatory mediator (interleukin-6) in Chang liver cells. carbonyl sulfide 13-16 interleukin 6 Homo sapiens 92-105 24581581-10 2014 In marginal structural models, IL-1beta, IL-6, IL-8 were associated with lower estradiol and progesterone concentrations. Estradiol 79-88 interleukin 6 Homo sapiens 41-45 24581581-10 2014 In marginal structural models, IL-1beta, IL-6, IL-8 were associated with lower estradiol and progesterone concentrations. Progesterone 93-105 interleukin 6 Homo sapiens 41-45 23979817-6 2014 Serum total testosterone was inversely correlated with age (r = -0.32, p < 0.05), CRP (r = -0.31, p < 0.05), and IL-6 (r = -0.24, p < 0.05). Testosterone 12-24 interleukin 6 Homo sapiens 119-123 24589569-5 2014 TET significantly inhibited the induction of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 by phorbol 12-myristate 13-acetate (PMA) plus A23187. Tetradecanoylphorbol Acetate 143-174 interleukin 6 Homo sapiens 111-129 24720799-4 2014 Melatonin treatment significantly reduced the mRNA and protein levels of MUC5AC and reduced interleukin (IL)-6 production in EGF-stimulated H292 cells. Melatonin 0-9 interleukin 6 Homo sapiens 92-110 24803317-8 2014 In addition to attenuation of lipopolysaccharide-induced expression of TNF-alpha, IL-1beta, IL-6 in macrophages, and human C-reactive protein in hepatocytes, respectively, at the transcriptional level in vitro, DHI also reduced TNF-alpha protein expression in aortic root of both Apoe-/- and Ldlr-/- mice, suggesting the importance of the anti-inflammatory properties of DHI in the inhibition of lesion development. dehydrosoyasaponin I 211-214 interleukin 6 Homo sapiens 92-96 24803317-8 2014 In addition to attenuation of lipopolysaccharide-induced expression of TNF-alpha, IL-1beta, IL-6 in macrophages, and human C-reactive protein in hepatocytes, respectively, at the transcriptional level in vitro, DHI also reduced TNF-alpha protein expression in aortic root of both Apoe-/- and Ldlr-/- mice, suggesting the importance of the anti-inflammatory properties of DHI in the inhibition of lesion development. dehydrosoyasaponin I 371-374 interleukin 6 Homo sapiens 92-96 24526008-4 2014 RESULT: Exogenous IL-10 (10(-8 )M) significantly (P<0.05) inhibited the endotoxin-stimulated release of IL-6, IL-8 and tumor necrosis factor by 63 to 82% with no significant effect by DEX and BETA. Dexamethasone 187-190 interleukin 6 Homo sapiens 107-111 24606079-7 2014 Vitamin D status was a significant predictor of the IL-6 to IL-10 cytokine ratio, and those participants defined as deficient were significantly more likely to have an IL-6 to IL-10 ratio >2:1 compared with those defined as sufficient. Vitamin D 0-9 interleukin 6 Homo sapiens 52-56 24606079-8 2014 CONCLUSIONS: This study demonstrated significant associations between low vitamin D status and markers of inflammation (including the ratio of IL-6 to IL-10) within elderly adults. Vitamin D 74-83 interleukin 6 Homo sapiens 143-147 24172719-12 2014 Carbohydrate and caffeine consumption before endurance cycling significantly increased the IL-6 release and leukocytosis, and the additional ingredients in ED seem to have further augmented these responses. Carbohydrates 0-12 interleukin 6 Homo sapiens 91-95 24401638-12 2014 CONCLUSION: High IL-6 levels and inflammatory burden score were associated with mortality in a cohort of HIV-infected adults with alcohol problems. Alcohols 130-137 interleukin 6 Homo sapiens 17-21 27547491-11 2014 RESULTS: Ethanol exposure suppressed HL1-1 cell growth [as measured by cell 5-bromo-2-deoxyuridine (BrdU) incorporation] mediated by epidermal growth factor (EGF) or EGF plus interleukin-6 (IL-6) in an ethanol dose-dependent manner. Ethanol 9-16 interleukin 6 Homo sapiens 175-188 27547491-11 2014 RESULTS: Ethanol exposure suppressed HL1-1 cell growth [as measured by cell 5-bromo-2-deoxyuridine (BrdU) incorporation] mediated by epidermal growth factor (EGF) or EGF plus interleukin-6 (IL-6) in an ethanol dose-dependent manner. Ethanol 9-16 interleukin 6 Homo sapiens 190-194 24720974-0 2014 A competitive electrochemical immunosensor for the detection of human interleukin-6 based on the electrically heated carbon electrode and silver nanoparticles functionalized labels. Carbon 117-123 interleukin 6 Homo sapiens 70-83 24574403-6 2014 NAB2 complexed with the cationic lipid Lipofectin but neither NAB2 nor Lipofectin alone induced the secretion of interleukin-12(p70) [IL-12(p70)], alpha interferon, gamma interferon-induced protein 10, macrophage inflammatory protein 1beta, or IL-6 in human monocyte-derived dendritic cells. alphaSYN-IN-NAB2 0-4 interleukin 6 Homo sapiens 244-248 24964617-11 2014 Both non-allergens SDS and IPA significantly induced IL-6 secretion in a dose-dependent manner however SDS cause a higher production levels, approximately 20 times of the control. Sodium Dodecyl Sulfate 19-22 interleukin 6 Homo sapiens 53-57 24771768-5 2014 Furthermore, the ability of resveratrol to suppress interleukin-6 transcription was shown to require ERalpha and several ERalpha coregulators, suggesting that ERalpha functions as a primary conduit for resveratrol activity.DOI: http://dx.doi.org/10.7554/eLife.02057.001. Resveratrol 28-39 interleukin 6 Homo sapiens 52-65 24755610-7 2014 RESULTS: p-Cresol and IL-6 were lower in UFout than in UFin both at the start and at the end of the HFR session, suggesting that they were retained by the cartridge. ufin 55-59 interleukin 6 Homo sapiens 22-26 24759736-9 2014 RESULT: H2O2 enhanced IL1beta-induced IL-6 and CXCL8 expression in NHBE and BEAS-2B cells whereas H2O2 alone did not have any affect. Hydrogen Peroxide 8-12 interleukin 6 Homo sapiens 38-42 24758565-9 2014 Comparison to established steroid sensitivity marker IL-6 confirmed that clinical responders are steroid refractory UC patients. Steroids 26-33 interleukin 6 Homo sapiens 53-57 24758565-9 2014 Comparison to established steroid sensitivity marker IL-6 confirmed that clinical responders are steroid refractory UC patients. Steroids 97-104 interleukin 6 Homo sapiens 53-57 24609629-10 2014 Expression of the mesenchymal markers alpha-SMA and fibronectin, interleukin-6 release, and Smad2 and MLC phosphorylation induced by TGF-beta2 were all inhibited by 17beta-estradiol and progesterone. Estradiol 165-181 interleukin 6 Homo sapiens 65-78 24609629-10 2014 Expression of the mesenchymal markers alpha-SMA and fibronectin, interleukin-6 release, and Smad2 and MLC phosphorylation induced by TGF-beta2 were all inhibited by 17beta-estradiol and progesterone. Progesterone 186-198 interleukin 6 Homo sapiens 65-78 24755610-8 2014 IL-6 mRNA expression and release were lower in PBMC incubated with UFout collected at the end than with UFin collected at the start of HFR, suggesting that passage through the cartridge reduced UF pro-inflammatory activity. ufin 104-108 interleukin 6 Homo sapiens 0-4 24733347-4 2014 Moreover, miR-144-3p mimics (agomir) enhanced the expression of inflammatory factors, including IL-1beta, IL-6 and TNF-alpha, in vivo and in vitro, inhibited cholesterol efflux in THP-1 macrophage-derived foam cells, decreased HDL-C circulation and impaired RCT in vivo, resulting in accelerated pathological progression of atherosclerosis in apoE-/- mice. Cholesterol 158-169 interleukin 6 Homo sapiens 106-110 24736635-4 2014 Co-treatment of AAMs with IL-6 resulted in spontaneous release of IL-10, suppressed LPS-induced nitric oxide production and inhibited cytokine production by activated CD4+ T cells - immunoregulatory features not observed in the "parent" IL-4+IL-13-induced AAM. Nitric Oxide 96-108 interleukin 6 Homo sapiens 26-30 24714343-0 2014 Paraquat-induced reactive oxygen species inhibit neutrophil apoptosis via a p38 MAPK/NF-kappaB-IL-6/TNF-alpha positive-feedback circuit. Reactive Oxygen Species 17-40 interleukin 6 Homo sapiens 95-99 24714343-6 2014 Furthermore, the proinflammatory mediators IL-6 and TNF-alpha could in turn promote ROS generation, creating a vicious cycle. Reactive Oxygen Species 84-87 interleukin 6 Homo sapiens 43-47 24334138-0 2014 Retinoic acid inhibits pancreatic cancer cell migration and EMT through the downregulation of IL-6 in cancer associated fibroblast cells. Tretinoin 0-13 interleukin 6 Homo sapiens 94-98 24473436-2 2014 We investigated the effect of IL-6 on insulin-stimulated glucose metabolism in type 2 diabetes patients and hypothesized that an acute, moderate IL-6 elevation would increase the insulin-mediated glucose uptake. Glucose 57-64 interleukin 6 Homo sapiens 30-34 24473436-2 2014 We investigated the effect of IL-6 on insulin-stimulated glucose metabolism in type 2 diabetes patients and hypothesized that an acute, moderate IL-6 elevation would increase the insulin-mediated glucose uptake. Glucose 57-64 interleukin 6 Homo sapiens 145-149 24473436-2 2014 We investigated the effect of IL-6 on insulin-stimulated glucose metabolism in type 2 diabetes patients and hypothesized that an acute, moderate IL-6 elevation would increase the insulin-mediated glucose uptake. Glucose 196-203 interleukin 6 Homo sapiens 30-34 24473436-2 2014 We investigated the effect of IL-6 on insulin-stimulated glucose metabolism in type 2 diabetes patients and hypothesized that an acute, moderate IL-6 elevation would increase the insulin-mediated glucose uptake. Glucose 196-203 interleukin 6 Homo sapiens 145-149 24334138-3 2014 We treated CAFs with RA and found that these cells became static due to the low expression of alpha-SMA, FAP, and IL-6 and decreased production of extracellular matrix (ECM). Tretinoin 21-23 interleukin 6 Homo sapiens 114-118 24334138-4 2014 Furthermore, we verified that the low secretion of IL-6 from CAFs was related to RA-induced inhibition of migration and epithelial-mesenchymal transition (EMT) of tumor cells. Tretinoin 81-83 interleukin 6 Homo sapiens 51-55 24370115-1 2014 An Interleukin-6 (IL-6) electrochemical immunosensor was fabricated based on the Au nanoparticles (AuNP)-graphene-silica sol-gel as immobilization biointerface and AuNP-polydopamine (PDA)@carbon nanotubes (CNT) as the label of HRP-bound antibodies. Carbon 188-194 interleukin 6 Homo sapiens 3-16 24370115-1 2014 An Interleukin-6 (IL-6) electrochemical immunosensor was fabricated based on the Au nanoparticles (AuNP)-graphene-silica sol-gel as immobilization biointerface and AuNP-polydopamine (PDA)@carbon nanotubes (CNT) as the label of HRP-bound antibodies. Carbon 188-194 interleukin 6 Homo sapiens 18-22 24225901-4 2014 Recently, altered iron metabolism in athletes has been attributed to postexercise increases in the iron regulatory hormone hepcidin, which has been reported to be upregulated by exercise-induced increases in the inflammatory cytokine interleukin-6. Iron 18-22 interleukin 6 Homo sapiens 234-247 24461623-10 2014 CONCLUSION: Consumption of a carbohydrate rich meal is associated with a rise in TG and fall in TC, HDL-C, LDL-C, IL-6 and TNF-alpha among normal individuals and people with type 2 diabetes. Carbohydrates 29-41 interleukin 6 Homo sapiens 114-118 24491813-5 2014 IL-6 ability to produce reactive oxygen species (ROS) and subsequently disturb the hepatic lipid balance has created a conundrum. Reactive Oxygen Species 24-47 interleukin 6 Homo sapiens 0-4 24491813-5 2014 IL-6 ability to produce reactive oxygen species (ROS) and subsequently disturb the hepatic lipid balance has created a conundrum. Reactive Oxygen Species 49-52 interleukin 6 Homo sapiens 0-4 24521260-5 2014 After treatment of normal human epidermal keratinocytes with TCDD or PCBs, IL-6 and IL-8 production were increased. Polychlorinated Dibenzodioxins 61-65 interleukin 6 Homo sapiens 75-79 24022566-0 2014 Oral L-arginine modulates blood lactate and interleukin-6 after exercise in HIV-infected men. Arginine 5-15 interleukin 6 Homo sapiens 44-57 24022566-9 2014 L-arg administration had no significant effect on TNF-alpha or IL-10 concentrations, but increased post-exercise IL-6 (placebo=19+-3pg.mL-1; L-arg=63+-8 pg.mL-1; p<0.05). Arginine 0-5 interleukin 6 Homo sapiens 113-117 24022566-10 2014 In HIV-1 infected men, acute administration of L-arg reduces post-exercise blood LAC and increases IL-6 levels, suggesting the activation of the L-arg-NO pathway, with possible anti-inflammatory consequences. Arginine 47-52 interleukin 6 Homo sapiens 99-103 24164541-1 2014 Aerosolized exposure to the chemical warfare vesicant sulfur mustard and its analog nitrogen mustard (HN2) is known to induce airway lesions associated with secretion of proinflammatory cytokines such as IL-6. Nitrogen 84-92 interleukin 6 Homo sapiens 204-208 24164541-4 2014 HN2-induced EGFR phosphorylation and IL-6 secretion in NHBECs were inhibited by the antioxidant N-acetyl-L-cysteine (NAC) and by the flavoprotein inhibitor diphenyleneiodonium chloride (DPI). Acetylcysteine 96-115 interleukin 6 Homo sapiens 37-41 24225901-4 2014 Recently, altered iron metabolism in athletes has been attributed to postexercise increases in the iron regulatory hormone hepcidin, which has been reported to be upregulated by exercise-induced increases in the inflammatory cytokine interleukin-6. Iron 99-103 interleukin 6 Homo sapiens 234-247 24474147-6 2014 RESULTS: Proinflammatory mediators IL-1beta and IL-6 were doubled in the controls versus the steroid treatment group at 21 hours following induction of acute vocal fold inflammation. Steroids 93-100 interleukin 6 Homo sapiens 48-52 25237354-5 2014 SERUM CONCENTRATIONS OF SAA (P: 0.02), CRP (P: 0.02) and ferritin (P: 0.01) significantly reduced in heparin group during measurements compared to baseline, circulating levels of IL-6 (P: 0.002), SAA (P: 0.009), CRP (P: 0.01) were significantly decreased in enoxaparin group. Heparin 101-108 interleukin 6 Homo sapiens 179-183 24681574-14 2014 IL-6 and HSP-70 release was significantly induced by IFN-gamma treatment, which was largely inhibited by NAC. Acetylcysteine 105-108 interleukin 6 Homo sapiens 0-4 24676135-7 2014 Moreover, cellular cytokines IL-1beta, IL-6, IL-8 and TNF-alpha secretion as well as NF-kappaB activation in THP-1 cells were attenuated under high iron conditions. Iron 148-152 interleukin 6 Homo sapiens 39-43 24598235-9 2014 When analyte levels were compared as to presenting or not each of the diagnostic features of the METS, it was found that IL-6 levels were higher among women with abdominal obesity, low HDL-C and high triglyceride levels. Triglycerides 200-212 interleukin 6 Homo sapiens 121-125 24363043-0 2014 Non-raft adenylyl cyclase 2 defines a cAMP signaling compartment that selectively regulates IL-6 expression in airway smooth muscle cells: differential regulation of gene expression by AC isoforms. Cyclic AMP 38-42 interleukin 6 Homo sapiens 92-96 24363043-10 2014 Our present study defines an AC2 cAMP signaling compartment that specifically regulates IL-6 expression in BSMC via Epac and PKA and demonstrates that other AC isoforms are excluded from this pool. Cyclic AMP 33-37 interleukin 6 Homo sapiens 88-92 24632893-5 2014 RESULTS: The combined measure of childhood adversity was associated with elevations in plasma levels of IL-6 (B = 0.009, p = .027, eta2 = 0.027, after controlling for age, body mass index, ethnicity, alcohol use, and cancer treatment (surgery, radiation, and/or chemotherapy). Alcohols 200-207 interleukin 6 Homo sapiens 104-108 24653700-6 2014 In addition, a connection between the loss of iron homeostasis and inflammation is starting to emerge; thus, inflammatory cytokines like TNF-alpha and IL-6 induce the synthesis of the divalent metal transporter 1 and promote iron accumulation in neurons and microglia. Iron 46-50 interleukin 6 Homo sapiens 151-155 24415766-4 2014 Two classes of IL-6 SOMAmers were isolated from modified DNA libraries containing 40 random positions and either 5-(N-benzylcarboxamide)-2"-deoxyuridine (Bn-dU) or 5-[N-(1-naphthylmethyl)carboxamide]-2"-deoxyuridine (Nap-dU) replacing dT. bn-du 154-159 interleukin 6 Homo sapiens 15-19 24415766-6 2014 Post-SELEX optimization of one Bn-dU and one Nap-dU SOMAmer led to improvements in IL-6 binding (10-fold) and inhibition activity (greater than 20-fold), resulting in lead SOMAmers with sub-nanomolar affinity (Kd = 0.2 nm) and potency (IC50 = 0.2 nm). bn-du 31-36 interleukin 6 Homo sapiens 83-87 24415766-6 2014 Post-SELEX optimization of one Bn-dU and one Nap-dU SOMAmer led to improvements in IL-6 binding (10-fold) and inhibition activity (greater than 20-fold), resulting in lead SOMAmers with sub-nanomolar affinity (Kd = 0.2 nm) and potency (IC50 = 0.2 nm). N-(4-aminophenethyl)spiroperidol 45-48 interleukin 6 Homo sapiens 83-87 24647589-7 2014 Fetal brains were collected after 6 h. In human fetal membranes, silibinin significantly decreased LPS-stimulated expression of IL-6 and IL-8, COX-2, and prostaglandins PGE2 and PGF2alpha. Silybin 65-74 interleukin 6 Homo sapiens 128-132 24647589-9 2014 Preterm fetal membranes with active infection treated with silibinin showed a decrease in IL-6, IL-8 and MMP-9 expression. Silybin 59-68 interleukin 6 Homo sapiens 90-94 24513877-7 2014 In addition, control levels of plasma malondialdehyde were positively correlated with differences in IL-6 levels between premiere and rehearsal (r=.38, p=.012), pointing to higher oxidative stress in individuals with pronounced IL-6 response. Malondialdehyde 38-53 interleukin 6 Homo sapiens 228-232 24594915-14 2014 CONCLUSIONS: LVAD-candidates with elevated pre-implant levels of IL-6 are associated, after intervention, to higher release of monocyte activation related-markers, a clue for the development of MOF, longer clinical course and poor outcome. lvad 13-17 interleukin 6 Homo sapiens 65-69 24361424-4 2014 Monocyte chemotactic protein-1 (MCP-1) and interleukin-6 (IL-6) were identified as two cytokines present in MCM, at concentrations that have previously been shown to influence VSMC phenotype. vsmc 176-180 interleukin 6 Homo sapiens 43-56 24361424-4 2014 Monocyte chemotactic protein-1 (MCP-1) and interleukin-6 (IL-6) were identified as two cytokines present in MCM, at concentrations that have previously been shown to influence VSMC phenotype. vsmc 176-180 interleukin 6 Homo sapiens 58-62 24837313-7 2014 Adenosine modified myeloid cells express also higher levels of mRNA of proinflammatory cytokines and chemoattractants (IL-6, IL-8, IL-1 b). Adenosine 0-9 interleukin 6 Homo sapiens 119-123 24252315-6 2014 KEY FINDINGS: Cultured macrophages challenged with zirconia or titanium particles expressed increased mRNA for TLRs 2, 3, 4 and 9, and their adaptors MyD88, TRIF and NF-kappaB and cytokines TNF-alpha, IL-1beta and IL-6, which were also increased at protein level. Titanium 63-71 interleukin 6 Homo sapiens 214-218 23625984-10 2014 Dexamethasone downregulated pro-inflammatory mediator (IL-1beta, IL-6, TNFalpha, IFNgamma, MMP-9, TIMP-1, CCL3 and CXCL8) mRNAs but did not modify expression of vascular remodelling factors (platelet derived growth factor, MMP-2 and collagens I and III). Dexamethasone 0-13 interleukin 6 Homo sapiens 65-69 24513877-7 2014 In addition, control levels of plasma malondialdehyde were positively correlated with differences in IL-6 levels between premiere and rehearsal (r=.38, p=.012), pointing to higher oxidative stress in individuals with pronounced IL-6 response. Malondialdehyde 38-53 interleukin 6 Homo sapiens 101-105 24308966-6 2014 High glucose induced gene profiling in Jurkat T-lymphocytes showed significantly increased expression of 64 proinflammatory genes including IL-6 and IL-17A and most of these genes were Nuclear Factor (NF)-kappaB and AP-1 regulated. Glucose 5-12 interleukin 6 Homo sapiens 140-144 24324051-8 2014 Serum CT-1 and IL-6 levels, which associated with the left ventricular mass index, correlated with superoxide production. Superoxides 99-109 interleukin 6 Homo sapiens 15-19 24488588-4 2014 The age-related decline in vitamin D receptor expression and 1,25(OH)D activity impact on proinflammatory cytokines such as tumor necrosis factor -alpha and interleukin-6 in skeletal muscle and vitamin D deficiency appears to enhance both bone marrow adipogenesis and intramuscular adipose tissue impacting as reduced functionality in both skeletal tissues. Vitamin D 27-36 interleukin 6 Homo sapiens 157-170 24456991-1 2014 Vitamin-D supplementation in vitamin-D insufficient/deficient prediabetes individuals is associated with significantly lower progression to diabetes (6/55 vs. 13/49; p=0.04) and higher reversal to normoglycemia (23/55 vs. 10/49; p=0.02), associated with decreased insulin resistance and systemic inflammation (TNFalpha and IL6). Vitamin D 0-9 interleukin 6 Homo sapiens 323-326 24397394-1 2014 OBJECTIVE: The aim of this study is to compare galanin and IL-6 levels in pregnant women with gestational diabetes mellitus (GDM) and normal glucose tolerance (NGT). Glucose 141-148 interleukin 6 Homo sapiens 59-63 24324051-10 2014 CT-1 stimulated NADPH oxidase superoxide production in peripheral blood mononuclear cells, which resulted in an increased release of IL-6. Superoxides 30-40 interleukin 6 Homo sapiens 133-137 24586431-8 2014 Activation of PAR-4 by a selective agonist was found to elicit the pro-inflammatory and pro-fibrotic phenotypes in PTEC while blockade of the receptor by specific antagonist attenuated high glucose-induced IL-6, CCL-2, CTGF and collagen IV expression. Glucose 190-197 interleukin 6 Homo sapiens 206-210 23981054-7 2014 RSV reduced Kupffer cells recruitment, the expressions of tumor necrosis factor-alpha and interleukin-6, but not interleukin-10. Resveratrol 0-3 interleukin 6 Homo sapiens 90-103 24484680-6 2014 PA remained associated with the rate of change in IL-6 even after controlling for extracellular water and fat mass. Water 96-101 interleukin 6 Homo sapiens 50-54 24576354-2 2014 Previous laboratory and clinical studies have shown that IL-6 causes a significant decrease in serum iron levels. Iron 101-105 interleukin 6 Homo sapiens 57-61 24576354-3 2014 Therefore, we conducted an epidemiological study to examine the association between serum IL-6 and iron levels. Iron 99-103 interleukin 6 Homo sapiens 90-94 24576354-8 2014 The logarithm of serum iron levels was negatively correlated with the logarithm of IL-6 levels in men (r = -0.19, p = 0.047), but not in women (r = -0.035, p = 0.65). Iron 23-27 interleukin 6 Homo sapiens 83-87 24576354-9 2014 Regression analysis, adjusted for sex, age, and H. pylori infection status, showed that the logarithm of serum iron levels was significantly associated with a decreased logarithm of IL-6 levels (beta = -0.053, p = 0.041). Iron 111-115 interleukin 6 Homo sapiens 182-186 24576354-10 2014 The odds ratio for low serum iron levels adjusted for sex, age, and H. pylori infection status was 7.88 (95% CI 1.29-48.06) in those with an IL-6 level > 4 pg/mL. Iron 29-33 interleukin 6 Homo sapiens 141-145 24576354-11 2014 CONCLUSION: Lower serum iron levels are significantly associated with higher serum IL-6 levels among Japanese adults. Iron 24-28 interleukin 6 Homo sapiens 83-87 24527095-8 2014 It was found that lipopolysaccharide and Pac significantly increase the secretion of IL-6 and IL-8 in the SKOV3 cell line. Paclitaxel 41-44 interleukin 6 Homo sapiens 85-89 24527095-9 2014 Similarly, Pac resulted in a significant upregulation of IL-6 and IL-8 in OVCAR3 cells, but not in A2780 and 3AO cells. Paclitaxel 11-14 interleukin 6 Homo sapiens 57-61 24549094-13 2014 NaCl 7.2%/6% hydroxyethyl starch 200/0.5 significantly reduces levels of IL-6 and IL-10 at 4 h after cardiopulmonary bypass and intercellular adhesion molecule 1 and E-selectin at 4 h after cardiopulmonary bypass and on postoperative day 1 (P < 0.05 for all). Sodium Chloride 0-4 interleukin 6 Homo sapiens 73-77 24513290-7 2014 Furthermore, curcumin, a histone acetyltransferase (HAT) inhibitor, significantly reduced the level of H3ac in the IL-6 promoter, as well as IL-6 mRNA expression and IL-6 protein secretion by RASFs. Curcumin 13-21 interleukin 6 Homo sapiens 115-119 24513290-7 2014 Furthermore, curcumin, a histone acetyltransferase (HAT) inhibitor, significantly reduced the level of H3ac in the IL-6 promoter, as well as IL-6 mRNA expression and IL-6 protein secretion by RASFs. Curcumin 13-21 interleukin 6 Homo sapiens 141-145 24513290-7 2014 Furthermore, curcumin, a histone acetyltransferase (HAT) inhibitor, significantly reduced the level of H3ac in the IL-6 promoter, as well as IL-6 mRNA expression and IL-6 protein secretion by RASFs. Curcumin 13-21 interleukin 6 Homo sapiens 141-145 24471583-0 2014 Electronic structure of H2S, SF2, and HSF and implications for hydrogen-substituted hypervalent sulfur fluorides. Hydrogen 63-71 interleukin 6 Homo sapiens 38-41 24374810-9 2014 DZ2002 (500 mumol/L) significantly suppressed TLR agonists-stimulated up-regulation in IL-6, IL-12p40, TNF-alpha, and IgG and IgM secretion as well as in HLA-DR and CD40 expression of dendritic cells among human PBMCs in vitro. methyl 4-(adenin-9-yl)-2-hydroxybutanoate 0-6 interleukin 6 Homo sapiens 87-91 24189439-0 2014 Autocrine production of interleukin-6 confers ovarian cancer cells resistance to tamoxifen via ER isoforms and SRC-1. Tamoxifen 81-90 interleukin 6 Homo sapiens 24-37 24189439-4 2014 Here we explore an association between IL-6 and TAM resistance. Tamoxifen 48-51 interleukin 6 Homo sapiens 39-43 24189439-5 2014 We demonstrate that both exogenous (a relatively short period of treatment with recombinant IL-6) and endogenous IL-6 (by transfecting with plasmid encoding for sense IL-6) induce TAM resistance in non-IL-6-expressing A2780 cells, while deleting of endogenous IL-6 expression in IL-6-overexpressing CAOV-3 cells (by transfecting with plasmid encoding for antisense IL-6) promotes the sensitivity of these cells to TAM. Tamoxifen 180-183 interleukin 6 Homo sapiens 92-96 24189439-5 2014 We demonstrate that both exogenous (a relatively short period of treatment with recombinant IL-6) and endogenous IL-6 (by transfecting with plasmid encoding for sense IL-6) induce TAM resistance in non-IL-6-expressing A2780 cells, while deleting of endogenous IL-6 expression in IL-6-overexpressing CAOV-3 cells (by transfecting with plasmid encoding for antisense IL-6) promotes the sensitivity of these cells to TAM. Tamoxifen 180-183 interleukin 6 Homo sapiens 113-117 24189439-5 2014 We demonstrate that both exogenous (a relatively short period of treatment with recombinant IL-6) and endogenous IL-6 (by transfecting with plasmid encoding for sense IL-6) induce TAM resistance in non-IL-6-expressing A2780 cells, while deleting of endogenous IL-6 expression in IL-6-overexpressing CAOV-3 cells (by transfecting with plasmid encoding for antisense IL-6) promotes the sensitivity of these cells to TAM. Tamoxifen 180-183 interleukin 6 Homo sapiens 113-117 24189439-5 2014 We demonstrate that both exogenous (a relatively short period of treatment with recombinant IL-6) and endogenous IL-6 (by transfecting with plasmid encoding for sense IL-6) induce TAM resistance in non-IL-6-expressing A2780 cells, while deleting of endogenous IL-6 expression in IL-6-overexpressing CAOV-3 cells (by transfecting with plasmid encoding for antisense IL-6) promotes the sensitivity of these cells to TAM. Tamoxifen 180-183 interleukin 6 Homo sapiens 113-117 24189439-5 2014 We demonstrate that both exogenous (a relatively short period of treatment with recombinant IL-6) and endogenous IL-6 (by transfecting with plasmid encoding for sense IL-6) induce TAM resistance in non-IL-6-expressing A2780 cells, while deleting of endogenous IL-6 expression in IL-6-overexpressing CAOV-3 cells (by transfecting with plasmid encoding for antisense IL-6) promotes the sensitivity of these cells to TAM. Tamoxifen 180-183 interleukin 6 Homo sapiens 113-117 24189439-5 2014 We demonstrate that both exogenous (a relatively short period of treatment with recombinant IL-6) and endogenous IL-6 (by transfecting with plasmid encoding for sense IL-6) induce TAM resistance in non-IL-6-expressing A2780 cells, while deleting of endogenous IL-6 expression in IL-6-overexpressing CAOV-3 cells (by transfecting with plasmid encoding for antisense IL-6) promotes the sensitivity of these cells to TAM. Tamoxifen 180-183 interleukin 6 Homo sapiens 113-117 24189439-5 2014 We demonstrate that both exogenous (a relatively short period of treatment with recombinant IL-6) and endogenous IL-6 (by transfecting with plasmid encoding for sense IL-6) induce TAM resistance in non-IL-6-expressing A2780 cells, while deleting of endogenous IL-6 expression in IL-6-overexpressing CAOV-3 cells (by transfecting with plasmid encoding for antisense IL-6) promotes the sensitivity of these cells to TAM. Tamoxifen 180-183 interleukin 6 Homo sapiens 113-117 24189439-6 2014 Further investigation indicates that TAM resistance caused by IL-6 is associated with the alteration of ERalpha, ERbeta and steroid hormone receptor coactivator (SRC)-1 expression levels, the protein interactions between SRC-1 and ERalpha, but not ERbeta, as well as blockage of estrogen-induced ER receptor nuclear translocation. Tamoxifen 37-40 interleukin 6 Homo sapiens 62-66 24189439-7 2014 These results show that IL-6 secreted by OVCA cells may contribute to the refractoriness of these cells to TAM via ER isoforms and SRC-1. Tamoxifen 107-110 interleukin 6 Homo sapiens 24-28 24189439-8 2014 Overexpression of IL-6 not only plays an important role in OVCA progression but also contributes to TAM resistance. Tamoxifen 100-103 interleukin 6 Homo sapiens 18-22 24189439-9 2014 Our studies suggest that TAM-IL-6-targeted adjunctive therapy may lead to a more effective intervention than TAM alone. Tamoxifen 25-28 interleukin 6 Homo sapiens 29-33 24533129-8 2014 Furthermore, Meth also stimulated a significant increased expression of IL-6 and TNF-alpha at protein level, which was significantly inhibited by MgTx. Methamphetamine 13-17 interleukin 6 Homo sapiens 72-76 24080305-2 2014 Given the demonstrated antiinflammatory function of vitamin D in multiple organ systems including trophoblast cells and placenta, we hypothesized that vitamin D deficiency contributes to the development of preeclampsia through increased inflammation, as indicated by elevated interleukin (IL)-6 concentrations. Vitamin D 151-160 interleukin 6 Homo sapiens 276-294 24444438-5 2014 Furthermore, NaHS also prevented I/R-induced oxidative stress and inflammatory responses, evidenced by increases in GSH level, decreases in MDA contents, reactive oxygen species generation and secretions of NO, IL-6 and TNF-alpha. sodium bisulfide 13-17 interleukin 6 Homo sapiens 211-215 24286513-8 2014 Acetyl-L-carnitine-cisplatin also caused reduced levels of IL-6, IL-1beta and TNF-alpha, pro-inflammatory cytokines, induced by cisplatin. Acetylcarnitine 0-18 interleukin 6 Homo sapiens 59-63 24032470-4 2014 We first uncover the cellular signaling pathways responsible: S1P activates a cyclic adenosine monophosphate/cAMP response-element-binding protein (CREB)/CRE-dependent pathway to induce IL-6 transcription, concomitant with stimulation of the mitogen-activated protein kinase (MAPK) superfamily and downstream mitogen and stress-activated protein kinase 1 (MSK1) and histone H3 phosphorylation. Cyclic AMP 78-108 interleukin 6 Homo sapiens 186-190 24032470-4 2014 We first uncover the cellular signaling pathways responsible: S1P activates a cyclic adenosine monophosphate/cAMP response-element-binding protein (CREB)/CRE-dependent pathway to induce IL-6 transcription, concomitant with stimulation of the mitogen-activated protein kinase (MAPK) superfamily and downstream mitogen and stress-activated protein kinase 1 (MSK1) and histone H3 phosphorylation. Cyclic AMP 109-113 interleukin 6 Homo sapiens 186-190 24032470-7 2014 The corticosteroid dexamethasone inhibits S1P-induced IL-6 protein secretion and mRNA expression, but CREB/CRE transrepression, inhibition of IL-6 mRNA stability, or subcellular relocation of MSK1 were not responsible for the repressive effects of dexamethasone. Dexamethasone 19-32 interleukin 6 Homo sapiens 54-58 24119518-3 2014 The IL-6-hepcidin antimicrobial peptide axis promotes iron-restricted anemia; however the full role of IL-6 in anemia of inflammation is not well-defined. Iron 54-58 interleukin 6 Homo sapiens 4-8 24519125-0 2014 Stress-related hormone norepinephrine induces interleukin-6 expression in GES-1 cells. Norepinephrine 23-37 interleukin 6 Homo sapiens 46-59 24519125-3 2014 However, the precise mechanism of IL-6 induction by the stress-related hormone norepinephrine (NE) is not clear, and, furthermore, there are no reports about the effect of NE on IL-6 expression in gastric epithelial cells. Norepinephrine 79-93 interleukin 6 Homo sapiens 34-38 24519125-8 2014 The results suggest that chronic stress may increase IL-6 secretion of human gastric epithelial cells, at least in part, by the stress-associated hormone norepinephrine, and provides basic data on stress and gastric cancer progression. Norepinephrine 154-168 interleukin 6 Homo sapiens 53-57 23981542-10 2014 Resveratrol was superior to dexamethasone in reducing CCL-2, IL-6 and IL-8 in LTA-exposed HASMCs of patients with COPD. Resveratrol 0-11 interleukin 6 Homo sapiens 61-65 24286513-8 2014 Acetyl-L-carnitine-cisplatin also caused reduced levels of IL-6, IL-1beta and TNF-alpha, pro-inflammatory cytokines, induced by cisplatin. Cisplatin 19-28 interleukin 6 Homo sapiens 59-63 24286513-8 2014 Acetyl-L-carnitine-cisplatin also caused reduced levels of IL-6, IL-1beta and TNF-alpha, pro-inflammatory cytokines, induced by cisplatin. Cisplatin 128-137 interleukin 6 Homo sapiens 59-63 24321183-7 2014 In patients with raised baseline plasma IL-6/8/10 and/or PTX3 the eGFR decline during the trial was significantly less in those treated with atorvastatin compared to placebo (mean change, -3.36; vs. + 1.25 mL/min/1.73 m2/year; difference, 4.61 95% CI 0.98 - 8.25; p = 0.002), whilst those without raised inflammatory biomarkers showed no difference. Atorvastatin 141-153 interleukin 6 Homo sapiens 40-49 24665995-0 2014 Effects of Janus kinase inhibitor tofacitinib on circulating serum amyloid A and interleukin-6 during treatment for rheumatoid arthritis. tofacitinib 34-45 interleukin 6 Homo sapiens 81-94 24665995-5 2014 Tofacitinib was also associated with reduced serum interleukin (IL)-6, but had no effect on serum levels of soluble IL-6 receptor. tofacitinib 0-11 interleukin 6 Homo sapiens 51-69 24665995-8 2014 These results suggest that tofacitinib down-regulates the proinflammatory cytokine, IL-6, accompanied by reduced serum SAA levels in patients with active RA. tofacitinib 27-38 interleukin 6 Homo sapiens 84-88 24665995-9 2014 The ability to regulate elevated serum IL-6 and SAA levels may explain the anti-inflammatory activity of tofacitinib. tofacitinib 105-116 interleukin 6 Homo sapiens 39-43 24248185-11 2014 IL-1beta, IL-6, and TNF-alpha stimulated the expression of UAPs and output of PGs in USMCs. Prostaglandins 78-81 interleukin 6 Homo sapiens 10-14 24342887-9 2014 Transcripts encoding interleukin (IL)-1beta and IL-6 were significantly decreased by tofacitinib treatment at post-thermocautery day 3. tofacitinib 85-96 interleukin 6 Homo sapiens 48-52 24296978-2 2014 Culturing LNCaP cells in androgen-depleted (AD) medium increased the levels of IL-6 and survivin, and treatment of the cells in AD medium with a combination of atorvastatin and celecoxib strongly inhibited the increase in IL-6 and survivin which is one of the downstream targets of the IL-6 signaling pathway. Atorvastatin 160-172 interleukin 6 Homo sapiens 222-226 22949302-5 2014 In addition, in THP-1 cells, oroxylin A significantly suppressed lipopolysaccharide (LPS)-induced secretion of prototypical proinflammatory cytokine IL-6 but not IL-1beta, and it was confirmed at the transcription level. 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one 29-39 interleukin 6 Homo sapiens 149-153 24709421-8 2014 IL-6 potentiated cisplatin-induced orosphere formation generated when primary human HNSCC cells were sorted for ALDH(high)CD44(high) immediately after surgery and plated onto ultralow attachment plates. Cisplatin 17-26 interleukin 6 Homo sapiens 0-4 24709421-9 2014 IL-6-induced signal transducer and activator of transcription 3 (STAT3) phosphorylation (indicative of stemness) was unaffected by treatment with cisplatin in UM-SCC-22B cells, whereas IL-6-induced extracellular signal-regulated kinase (ERK) phosphorylation (indicative of differentiation processes) was partially inhibited by cisplatin. Cisplatin 327-336 interleukin 6 Homo sapiens 0-4 24622832-11 2014 Statistically significantly lower levels of IL-1, IL-6 and TNF-alpha were observed in patients receiving melatonin and tryptophan, comparing with group III treated with Essentiale forte only. Melatonin 105-114 interleukin 6 Homo sapiens 50-54 24622832-11 2014 Statistically significantly lower levels of IL-1, IL-6 and TNF-alpha were observed in patients receiving melatonin and tryptophan, comparing with group III treated with Essentiale forte only. Tryptophan 119-129 interleukin 6 Homo sapiens 50-54 24296978-0 2014 Inhibition of IL-6 expression in LNCaP prostate cancer cells by a combination of atorvastatin and celecoxib. Atorvastatin 81-93 interleukin 6 Homo sapiens 14-18 24296978-1 2014 In the present study, we investigated the effect of a combination of atorvastatin and celecoxib on the formation of interleukin (IL)-6, a cytokine that is increased during the progression of LNCaP tumors from androgen dependence to androgen independence. Atorvastatin 69-81 interleukin 6 Homo sapiens 116-134 24296978-3 2014 Addition of recombinant IL-6 partially abrogated the combined effect of atorvastatin and celecoxib on apoptosis in LNCaP cells cultured in AD medium. Atorvastatin 72-84 interleukin 6 Homo sapiens 24-28 24296978-2 2014 Culturing LNCaP cells in androgen-depleted (AD) medium increased the levels of IL-6 and survivin, and treatment of the cells in AD medium with a combination of atorvastatin and celecoxib strongly inhibited the increase in IL-6 and survivin which is one of the downstream targets of the IL-6 signaling pathway. Atorvastatin 160-172 interleukin 6 Homo sapiens 79-83 24296978-2 2014 Culturing LNCaP cells in androgen-depleted (AD) medium increased the levels of IL-6 and survivin, and treatment of the cells in AD medium with a combination of atorvastatin and celecoxib strongly inhibited the increase in IL-6 and survivin which is one of the downstream targets of the IL-6 signaling pathway. Atorvastatin 160-172 interleukin 6 Homo sapiens 222-226 24296978-6 2014 Our results indicate that decreases in IL-6 and survivin levels by atorvastatin and celecoxib administration are associated with increased apoptosis in LNCaP cells treated with this drug combination. Atorvastatin 67-79 interleukin 6 Homo sapiens 39-43 24296978-7 2014 Our in vivo studies indicate that the inhibitory effect of a combination of atorvastatin and celecoxib on the progression of androgen-dependent LNCaP xenograft tumors to androgen independence is associated with inhibition of the increase in IL-6 and survivin that occurs when androgen-dependent LNCaP prostate tumors become androgen-independent. Atorvastatin 76-88 interleukin 6 Homo sapiens 241-245 24287143-7 2014 The high levels of cytokines IL-1beta, TNF-alpha, and IL-6 from the diversion colitis explants decreased (P < .05) to near normal values with heparin treatments. Heparin 145-152 interleukin 6 Homo sapiens 54-58 24735628-9 2014 RESULTS: H2O2 and LPS significantly decreased HUVECs viability, increased the contents of MDA, IL-6 and decreased the contents of SOD and GSH-Px, and increased the apoptosis rate [(37.8 +- 1.8)% and (38.9 +- 1.1)%]. Hydrogen Peroxide 9-13 interleukin 6 Homo sapiens 95-99 24128422-2 2014 We investigated the effect of lipopolysacharide (LPS) and progesterone (P4) upon expression of TLR-4/MyD88, TNFalpha, IL-6, IL-8, IL-10, and HBD2 on the human amniotic epithelium. Progesterone 58-70 interleukin 6 Homo sapiens 118-122 24296301-9 2014 Antioxidant treatments (deferoxamine mesylate, (+-)alpha-tocopherol, or tempol) suppressed BDE-47-stimulated IL-6 release by 54.1%, 56.3% and 37.7%, respectively, implicating a role for ROS in the regulation of inflammatory pathways in HTR-8/SVneo cells. Reactive Oxygen Species 186-189 interleukin 6 Homo sapiens 109-113 24454842-10 2014 An increase in CSF IL-6 was observed in participants who reported drinking >0-1 (p<0.05) and >1 (p<0.05) standard alcoholic drinks per day compared to those who did not drink alcohol. Alcohols 126-133 interleukin 6 Homo sapiens 19-23 23944957-10 2014 IL-6 was less suppressible by dexamethasone in patients with nonsevere and severe asthma, compared with healthy subjects. Dexamethasone 30-43 interleukin 6 Homo sapiens 0-4 24400858-5 2014 Treatment of primary neonatal human keratinocytes with 1 followed by activation with phorbol ester/ionomycin showed a significant reduction in IL-6 secretion. Ionomycin 99-108 interleukin 6 Homo sapiens 143-147 24465925-7 2014 For COX-2 and IL-6 this increase of mRNA is due to an mRNA stabilizing effect of TE and betulin, a process in which p38 MAPK and HuR are involved. betulin 88-95 interleukin 6 Homo sapiens 14-18 24575367-1 2014 Aim The objective of the study was to identify the association if any, of inflammatory markers (adiponectin and IL-6) with fasting glucose in normoglycemic (healthy), prediabetic (impaired fasting glucose), and hyperglycemic (diabetic) people in Indian population. Glucose 131-138 interleukin 6 Homo sapiens 112-116 24575367-6 2014 Similarly significant increase was also observed in IL-6 level in hyperglycemic and impaired fasting glucose groups compared with normoglycemic group. Glucose 101-108 interleukin 6 Homo sapiens 52-56 24575367-7 2014 Conclusions From our data it can be summarized that there is a significant change in both adiponectin (reduction) and IL-6 (increase) levels in normoglycemic (healthy), prediabetic (impaired fasting glucose), and hyperglycemic (diabetic) population in Indian population. Glucose 199-206 interleukin 6 Homo sapiens 118-122 25162011-7 2014 RA produced a significant reduction in UVB-induced expression of IL-6, IL-8, MCP-1, and TNF-alpha when applied at the same time as irradiation. rosmarinic acid 0-2 interleukin 6 Homo sapiens 65-69 24127660-8 2014 Azelastine, an H1 receptor antagonist approved for the treatment of seasonal allergic rhinitis, nonallergic vasomotor rhinitis, and ocular conjunctivitis, was subsequently confirmed as a selective inhibitor of IL-6-induced pSTAT3 activation that also reduced the growth of HNSCC cell lines. azelastine 0-10 interleukin 6 Homo sapiens 210-214 25147797-5 2014 Increases of IL-6 and IL-8 release (by ELISA) were detected in A549 cells exposed to MWCNTs-COOH from 10 mug/mL while IL-8 increased in BEAS-2B cells exposed to pristine MWCNTs at 20 and 40 mug/mL. Carbonic Acid 92-96 interleukin 6 Homo sapiens 13-17 25226915-6 2014 Furthermore, Ad-GDNF significantly decreased the levels of IL-6 and TNF-a and increased Bcl-2/Bax ratio in BMSCs treated by H2O2. Hydrogen Peroxide 124-128 interleukin 6 Homo sapiens 59-63 24995301-3 2014 SB203580 is a selective ATP-competitive inhibitor of the p38 mitogen-activated protein kinase (MAPK), which is involved in the regulation of proinflammatory cytokines IL-1beta, IL-6 and TNFalpha synthesis. Adenosine Triphosphate 24-27 interleukin 6 Homo sapiens 177-181 25170632-9 2014 RESULTS: We found that the neuromediators histamine and substance P were able to stimulate microglial activation and the subsequent production of ROS and proinflammatory factors TNF-alpha and IL-6. Histamine 42-51 interleukin 6 Homo sapiens 192-196 24126150-3 2014 Therefore, the objective of this study was to examine the inhibitory effect of an exogenous GC (dexamethasone, DEX) on leptin- and lipopolysaccharide (LPS)-induced IL-6 production by peripheral blood mononuclear cells (PBMCs) ex vivo in obese subjects compared to normal-weight subjects. Dexamethasone 96-109 interleukin 6 Homo sapiens 164-168 23849060-8 2014 Here supernatants taken from AMP cell/monocyte cocultures yielded significant levels of regulatory cytokines, such as PGE2, IL-6, IL-10, and MIC-1. Adenosine Monophosphate 29-32 interleukin 6 Homo sapiens 124-128 26155135-3 2014 The results showed that both DEX and CsA dose-dependently inhibited the production of eleven cytokines: interleukin (IL)-2, IL-4, IL-5, IL-6, IL-13, IL-17, interferon gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha), granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF). Dexamethasone 29-32 interleukin 6 Homo sapiens 136-140 26155135-3 2014 The results showed that both DEX and CsA dose-dependently inhibited the production of eleven cytokines: interleukin (IL)-2, IL-4, IL-5, IL-6, IL-13, IL-17, interferon gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha), granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF). Cyclosporine 37-40 interleukin 6 Homo sapiens 136-140 23990363-6 2014 Haploinsufficiency and short hairpin RNA-based knockdown of ATF4 in macrophages markedly inhibited SFA- and metabolic stress-induced Il6 expression. Fatty Acids 99-102 interleukin 6 Homo sapiens 133-136 24372204-4 2014 Both, ectoine and lauryl-ectoine considerably decreased lipopolysaccharide (LPS)-induced interleukin (IL)- 1, IL-6, tumor necrosis factor (TNF)- alpha, and cyclooxygenase (COX)-2 gene expression in macrophages as well as TNF-alpha- induced IL-1, IL-6 and COX-2 expression in RISM cells. lauryl-ectoine 18-32 interleukin 6 Homo sapiens 110-114 24372204-4 2014 Both, ectoine and lauryl-ectoine considerably decreased lipopolysaccharide (LPS)-induced interleukin (IL)- 1, IL-6, tumor necrosis factor (TNF)- alpha, and cyclooxygenase (COX)-2 gene expression in macrophages as well as TNF-alpha- induced IL-1, IL-6 and COX-2 expression in RISM cells. lauryl-ectoine 18-32 interleukin 6 Homo sapiens 246-250 24563430-9 2014 Last, recent findings suggested that cefditoren can be a valid alternative to levofloxacin in outpatients with acute exacerbation of COPD; in this setting a treatment with cefditoren showed to be associated with a significant reduction of some key inflammatory markers involved in epithelial damage, including KL-6 and IL-6. cefditoren 172-182 interleukin 6 Homo sapiens 319-323 25487935-12 2014 CONCLUSIONS: The concentration of interleukin-6 in younger people, including those with normal body weight, correlated with total cholesterol and triglyceride levels, and it was significantly higher in obese women compared to those with normal body weight. Cholesterol 130-141 interleukin 6 Homo sapiens 34-47 25487935-12 2014 CONCLUSIONS: The concentration of interleukin-6 in younger people, including those with normal body weight, correlated with total cholesterol and triglyceride levels, and it was significantly higher in obese women compared to those with normal body weight. Triglycerides 146-158 interleukin 6 Homo sapiens 34-47 25185427-0 2014 Effect of 13q deletion on IL-6 production in patients with multiple myeloma: a hypothesis may hold true. 13q 10-13 interleukin 6 Homo sapiens 26-30 24392463-11 2014 Correlation between serum TNF-a and IL6 levels with healthy donors were statistically significant in 1h (0.004), 2h (0.001), 24h (0.001) and 48h (0.001 and 0.001) postoperatively, respectively. Hydrogen 101-103 interleukin 6 Homo sapiens 36-39 24200052-6 2014 Interaction between PPARgamma Pro12Ala and IL6 -174G>C improved prediction of high fasting blood glucose (chi(2)=13.99; df=1; p<0.001). Glucose 100-107 interleukin 6 Homo sapiens 43-46 24200052-7 2014 PPARgamma Ala12 variant was found protective in patients with IL6 -174GG genotype (OR=0.10; 95% CI: 0.02-0.57, p=0.01), while in the case of IL6 -174C allele carriers, for PPARgamma Ala12 carriers, larger odds for high glucose levels compared with Pro12 variant were observed (OR=2.39; 95% CI: 1.11-5.17, p=0.026). Glucose 219-226 interleukin 6 Homo sapiens 141-144 25464609-5 2014 RESULTS: Therapy with atorvastatin (20 to 40 mg/day) facilitated reduction of serum concentration of acute phase proteins (C-reactive protein and neopterin) and decrease of spontaneous production by blood mononuclear leukocytes of proinflammatory cytokines (interleukin [IL]-1beta, IL-6 and tumor necrosis factor [TNF]-alpha) and reactive oxygen species. Atorvastatin 22-34 interleukin 6 Homo sapiens 282-286 24173391-5 2014 Ovarian steroids (17beta-estradiol and progesterone) and inflammatory factors (tumor necrosis factor-alpha and interleukin-6) decreased the expression of miR-183 in the ESCs. Steroids 8-16 interleukin 6 Homo sapiens 111-124 25365998-5 2014 RESULTS: The production of monocyte TNF-alpha and IL-6 was found to be significantly and negatively associated with the serum low-density lipoprotein (LDL)-cholesterol level (TNF-alpha: r=-0.515, p<0.001, IL-6: r=-0.419, p<0.001). Cholesterol 156-167 interleukin 6 Homo sapiens 50-54 25068589-8 2014 The secretion of the cytokines IL-6 and TNF-alpha was shown to be chemistry-dependent upon stimulation with carbohydrate-functionalized nanoparticles. Carbohydrates 108-120 interleukin 6 Homo sapiens 31-35 25464609-6 2014 Dynamics of cytokine concentrations in supernatants of mononuclear leukocytes obtained after incubation of the cells with atorvastatin in vitro confirmed the assumption of direct inhibitory effect of this drug on spontaneous production of some proinflammatory cytokines (IL-6 and monocyte chemotactic protein-1). Atorvastatin 122-134 interleukin 6 Homo sapiens 271-275 23461716-5 2014 Pre-operative steroids were associated with statistically significant reductions in the levels of serum bilirubin and interleukin 6 (IL-6) on post-operative day one. Steroids 14-22 interleukin 6 Homo sapiens 118-131 23461716-5 2014 Pre-operative steroids were associated with statistically significant reductions in the levels of serum bilirubin and interleukin 6 (IL-6) on post-operative day one. Steroids 14-22 interleukin 6 Homo sapiens 133-137 24016202-0 2014 Protective role of 17-beta-estradiol towards IL-6 leukocyte expression induced by intense training in young female athletes. Estradiol 19-36 interleukin 6 Homo sapiens 45-49 24966472-6 2014 RESULTS: NaHS significantly reduced the levels of TNF- alpha and IL-6 at 12 h and 24 h after injection compared with ischemia/reperfusion challenge alone. sodium bisulfide 9-13 interleukin 6 Homo sapiens 65-69 25089076-6 2014 Puerarin also reduced the upregulated levels of nuclear factor-kappaB (NF-kappaB) and other proinflammatory cytokines, such as IL-6, IL-1beta, and TNF-alpha, in the spinal cord. puerarin 0-8 interleukin 6 Homo sapiens 127-131 23793235-7 2014 Transient transfection experiments showed that IL-6 induced the expression of a reporter gene under the control of a cAMP response element-like region in the human FAAH promoter. Cyclic AMP 117-121 interleukin 6 Homo sapiens 47-51 24434384-0 2014 The effect of treatment with N-acetylcysteine on the serum levels of C-reactive protein and interleukin-6 in patients on hemodialysis. Acetylcysteine 29-45 interleukin 6 Homo sapiens 92-105 25530684-7 2014 KEY RESULTS: Treating A549 with EtOH or EtP reduced substantially the cytokine-induced release of IL-8 and IL-6. Ethanol 32-36 interleukin 6 Homo sapiens 107-111 24434384-3 2014 We aimed to assess the effect of three months treatment with oral NAC on the plasma levels of inflammatory mediators like interleukin-6 (IL-6) and C-reactive protein (hs-CRP) in patients on hemodialysis (HD). Acetylcysteine 66-69 interleukin 6 Homo sapiens 122-135 24434384-3 2014 We aimed to assess the effect of three months treatment with oral NAC on the plasma levels of inflammatory mediators like interleukin-6 (IL-6) and C-reactive protein (hs-CRP) in patients on hemodialysis (HD). Acetylcysteine 66-69 interleukin 6 Homo sapiens 137-141 24434384-10 2014 In three subjects who were less than 40 years old, the hs-CRP and IL-6 levels showed an increase following NAC treatment. Acetylcysteine 107-110 interleukin 6 Homo sapiens 66-70 24434384-11 2014 Our study found that short-term oral NAC treatment might result in the reduction of IL-6 and hs-CRP in patients who are on regular HD. Acetylcysteine 37-40 interleukin 6 Homo sapiens 84-88 25509145-4 2014 Comprehensive assessment of the results after has shown that 3-day HUVEC cultivating in the presence of 1% O2 led to pathological activation of endotheliocytes: increased NO synthesis combined with the marked secretion of endothelin-1, IL-6, IL-8 and TNF-alpha, sVCAM-1, sE-cadherin and of sE-selectin, VEGF-A and bFGF, and slow proliferation. Oxygen 107-109 interleukin 6 Homo sapiens 236-240 24754180-5 2014 Compared to the human leukemia NOD/SCID mouse model group with the treatments of APS, Ara-c and APS + Ara-c, We found that severe liver damage and pathological changes of the liver were able to alleviate: First, the number of white blood cells in the peripheral blood was significantly lower and with less transplanted K562 leukemia cells; Second, liver function damage was alleviated as liver function tests showed that alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBiL) were significantly reduced, while the albumin (Alb) was notably increased; Third, liver antioxidant ability was improved as the activities of the antioxidant enzymes glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were significantly increased, and the contents of GSH and malonaldehyde (MDA) were decreased significantly in the liver; Fourth, the inflammation of the liver was relieved as the level of IL-1beta and IL-6, the inflammatory cytokines, were decreased significantly in the liver. aps 96-99 interleukin 6 Homo sapiens 943-947 24134915-2 2013 Flavone effects were assessed on soluble pro-inflammatory mediator (IL-8, IL-6, macrophage chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2)-derived PGE2) production and on nuclear factor (NF)-kappaB activation in 3d-confluent and 21d-differentiated Caco-2 cells stimulated with interleukin (IL)-1beta. flavone 0-7 interleukin 6 Homo sapiens 74-78 24380387-8 2013 In vitro, berberine inhibited both constitutive and IL-6-induced STAT3 activation in NPC cells. Berberine 10-19 interleukin 6 Homo sapiens 52-56 23906537-5 2013 We report for the first time that in addition to STAT3, Fer is required for IL-6 mediated AR activation by phosphorylating AR tyrosine 223 and binding via its SH2 domain. Tyrosine 126-134 interleukin 6 Homo sapiens 76-80 24349194-8 2013 Moreover, adipocyte incubation with BPA was accompanied by increased release of IL-6 and IFN-gamma, as assessed by multiplex ELISA assays, and by activation of JNK, STAT3 and NFkB pathways. bisphenol A 36-39 interleukin 6 Homo sapiens 80-84 24115033-10 2013 CONCLUSIONS: Interleukin-6 stimulates the translocation of HDL through the endothelium, the first step in reverse cholesterol transport pathway, by enhancing EL expression. Cholesterol 114-125 interleukin 6 Homo sapiens 13-26 24291824-0 2013 ER stress upregulated PGE2/IFNgamma-induced IL-6 expression and down-regulated iNOS expression in glial cells. Dinoprostone 22-26 interleukin 6 Homo sapiens 44-48 24291824-8 2013 Thus, cAMP has a dual effect on immune reactions; cAMP up-regulated IL-6 expression, but down-regulated iNOS expression under ER stress. Cyclic AMP 6-10 interleukin 6 Homo sapiens 68-72 24291824-8 2013 Thus, cAMP has a dual effect on immune reactions; cAMP up-regulated IL-6 expression, but down-regulated iNOS expression under ER stress. Cyclic AMP 50-54 interleukin 6 Homo sapiens 68-72 23880643-10 2013 IL-6 was detected in low O2 but not ambient O2 ASC medium. Oxygen 25-27 interleukin 6 Homo sapiens 0-4 24140851-8 2013 The higher heating value (HHV) and oxygen content of HSF from humin were fully compatible with biofuel characteristics. Oxygen 35-41 interleukin 6 Homo sapiens 53-56 24479719-3 2013 Norepinephrine and other adrenoceptor agonists are known to provoke activation of proinflammatory cytokines such as interleukin (IL)-1 and IL-6. Norepinephrine 0-14 interleukin 6 Homo sapiens 139-143 24101153-6 2013 In addition, elevated reactive oxygen species (ROS) produced upon protein depletion was required for the activation of IL-6/STAT3 in D5HS. Reactive Oxygen Species 22-45 interleukin 6 Homo sapiens 119-123 24101153-6 2013 In addition, elevated reactive oxygen species (ROS) produced upon protein depletion was required for the activation of IL-6/STAT3 in D5HS. Reactive Oxygen Species 47-50 interleukin 6 Homo sapiens 119-123 24101153-7 2013 Importantly, a positive feedback loop was found between ROS and IL-6 during tumor sphere formation. Reactive Oxygen Species 56-59 interleukin 6 Homo sapiens 64-68 24101153-10 2013 The intrinsic association of ROS and IL-6/STAT3 signaling in human prostate carcinogenesis shed new light on this relationship and define therapeutic targets in this setting. Reactive Oxygen Species 29-32 interleukin 6 Homo sapiens 37-41 24266263-6 2013 Pre- and co-treatments with RSV-LNC were able to protect cultures against ROS formation and cell death induced by Abeta, possibly through sustained blocking of TNF-alpha, IL-1beta, and IL-6 release. Resveratrol 28-31 interleukin 6 Homo sapiens 185-189 24157330-6 2013 Using an antibody array approach, curcumin was found to inhibit LPS-induced cytokine production, including MIP-1alpha, MIP-1beta, IL-6, IL-8 (CXCL-8) and GRO-alpha. Curcumin 34-42 interleukin 6 Homo sapiens 130-134 23339932-0 2013 Interleukin-6 is associated with steroid resistance and reflects disease activity in severe pediatric ulcerative colitis. Steroids 33-40 interleukin 6 Homo sapiens 0-13 23656570-5 2013 RESULTS: Statistical analysis showed three doses of 0.5 (p = 0.049), 1 (p = 0.027), and 2 J/cm(2) (p = 0.004) stimulated the release of IL-6 in HSFs cultured in high glucose concentration medium compared with that of non-irradiated HSFs that were cultured in the same medium. Glucose 166-173 interleukin 6 Homo sapiens 136-140 23656570-7 2013 CONCLUSION: Our study showed that LLLT stimulated the release of IL-6 and bFGF from HSFs cultured in high glucose concentration medium. Glucose 106-113 interleukin 6 Homo sapiens 65-69 24041966-7 2013 Moreover, PAC were highly resistant to complement-mediated lysis and primarily responded to human complement by releasing IL-6 and IL-8. pac 10-13 interleukin 6 Homo sapiens 122-126 24267042-0 2013 Soy proteins and isoflavones reduce interleukin-6 but not serum lipids in older women: a randomized controlled trial. Isoflavones 17-28 interleukin 6 Homo sapiens 36-49 24080250-9 2013 Montelukast significantly suppressed the release of IL-8 (p = 0.016), IL-6 (p = 0.006), RANTES (p = 0.002) and IFN-gamma (p = 0.046), in a dose dependent manner in unstimulated cultures but not in those stimulated with IL-1/TNF. montelukast 0-11 interleukin 6 Homo sapiens 70-74 24120989-8 2013 Moreover, H2O2-induced release of IL-9, TNF-alpha, MIP-1alpha and MIP-1beta was not counteracted by DPI, whereas no effect was observed in any experimental condition for both IL-6 and IL-1beta. Hydrogen Peroxide 10-14 interleukin 6 Homo sapiens 175-179 24094983-0 2013 Pre-treatment with calcium prevents endothelial cell activation induced by multiple activators, necrotic trophoblastic debris or IL-6 or preeclamptic sera: possible relevance to the pathogenesis of preeclampsia. Calcium 19-26 interleukin 6 Homo sapiens 129-133 24094983-6 2013 Endothelial cells were treated with varied concentrations of calcium prior to exposure to NTD, IL-6 or preeclamptic sera or low levels of calcium. Calcium 61-68 interleukin 6 Homo sapiens 95-99 24094983-9 2013 RESULTS: Pre-treatment with increasing concentrations of calcium inhibited the activation of endothelial cells in response to NTD or IL-6 or preeclamptic sera. Calcium 57-64 interleukin 6 Homo sapiens 133-137 24436991-5 2013 Isonahocol E(3) significantly inhibited ET-1-induced cell proliferation, as well as inflammatory mediators, such as interleukin-6 (IL-6) and interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha), and pro-angiogenic factors including metalloproteinases in immortalized human keratinocytes. isonahocol E(3) 0-15 interleukin 6 Homo sapiens 116-129 23973924-11 2013 In addition, 17beta-estradiol attenuated the LPS-evoked increase in tumoral lactotroph proliferation and IL-6 release. Estradiol 13-29 interleukin 6 Homo sapiens 105-109 24177007-0 2013 ER stress-mediated regulation of immune function under glucose-deprived condition in glial cells: up- and down-regulation of PGE2 + IFNgamma-induced IL-6 and iNOS expressions. Dinoprostone 125-129 interleukin 6 Homo sapiens 149-153 24177007-5 2013 These dual effects would be mediated through endoplasmic reticulum (ER) stress, because we observed (1) up-regulation of GRP78 and CHOP under glucose-deprived condition, which was inhibited by chemical chaperon TMAO, and (2) treatment with TMAO inhibited IL-6 production under glucose-deprived condition. Glucose 142-149 interleukin 6 Homo sapiens 255-259 24436991-5 2013 Isonahocol E(3) significantly inhibited ET-1-induced cell proliferation, as well as inflammatory mediators, such as interleukin-6 (IL-6) and interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha), and pro-angiogenic factors including metalloproteinases in immortalized human keratinocytes. isonahocol E(3) 0-15 interleukin 6 Homo sapiens 131-135 24649055-10 2013 The application of aspirin (0.1 mM) significantly inhibited the activation of ERK1/2 and NF-kappaB, the expression of TNF-alpha, IL-6, IL-1beta and MCP-1 genes and the secretion of TNF-alpha and IL-6. Aspirin 19-26 interleukin 6 Homo sapiens 129-133 23740369-8 2013 Stress hormones such as norepinephrine have been shown to cause upregulation of cytokines such as Interleukin 6 and 8, which are proangiogenic and support tumour progression. Norepinephrine 24-38 interleukin 6 Homo sapiens 98-117 24260381-5 2013 Transient transfection assays showed that scoparone repressed both constitutive and IL-6-induced transcriptional activity of STAT3. scoparone 42-51 interleukin 6 Homo sapiens 84-88 24062309-6 2013 Antioxidants and low oxygen tension prevented SA IL-1alpha expression and restricted expression of SASP components IL-6 and IL-8. Oxygen 21-27 interleukin 6 Homo sapiens 115-119 24192293-5 2013 RESULTS: Expression of STAT3-YF-YFP impairs tyrosine phosphorylation, nuclear translocation and the transcriptional activity of WT-STAT3 in IL-6-stimulated cells. Tyrosine 44-52 interleukin 6 Homo sapiens 140-144 24649055-10 2013 The application of aspirin (0.1 mM) significantly inhibited the activation of ERK1/2 and NF-kappaB, the expression of TNF-alpha, IL-6, IL-1beta and MCP-1 genes and the secretion of TNF-alpha and IL-6. Aspirin 19-26 interleukin 6 Homo sapiens 195-199 24046362-3 2013 Short-term treatment with iodoacetamide mimicked experimental intestinal inflammation in IBD, as indicated by histological alterations such as hemorrhage, hyperemia and loss of regular crypt architecture, as well as enhanced expression of cytokines (e.g. IL-6, IL-10 and MCP-1) compared with control segments perfused with media. Iodoacetamide 26-39 interleukin 6 Homo sapiens 255-259 23998285-8 2013 At daytime, melatonin 1 and 10 mg reduced the levels of MDA and increased SOD, IL-6, IL-10, and DHA (p < 0.05). Melatonin 12-21 interleukin 6 Homo sapiens 79-83 24009302-6 2013 Associations for IL-1RA and IL-6 with the MNSI score remained statistically significant after additional adjustment for waist circumference, height, hypertension, cholesterol, smoking, alcohol intake, physical activity, history of myocardial infarction or stroke, presence of neurological conditions, and use of nonsteroidal anti-inflammatory drugs. Cholesterol 163-174 interleukin 6 Homo sapiens 28-32 24009302-6 2013 Associations for IL-1RA and IL-6 with the MNSI score remained statistically significant after additional adjustment for waist circumference, height, hypertension, cholesterol, smoking, alcohol intake, physical activity, history of myocardial infarction or stroke, presence of neurological conditions, and use of nonsteroidal anti-inflammatory drugs. Alcohols 185-192 interleukin 6 Homo sapiens 28-32 24026137-0 2013 Norepinephrine and adenosine-5"-triphosphate synergize in inducing IL-6 production by human dermal microvascular endothelial cells. Norepinephrine 0-14 interleukin 6 Homo sapiens 67-71 24026137-0 2013 Norepinephrine and adenosine-5"-triphosphate synergize in inducing IL-6 production by human dermal microvascular endothelial cells. Adenosine Triphosphate 19-44 interleukin 6 Homo sapiens 67-71 24026137-4 2013 Strikingly, NE and ATP synergistically induced release of IL-6 by a human dermal microvascular endothelial cell line (HMEC-1). Adenosine Triphosphate 19-22 interleukin 6 Homo sapiens 58-62 24121064-0 2013 Sertraline decreases serum level of interleukin-6 (IL-6) in hemodialysis patients with depression: results of a randomized double-blind, placebo-controlled clinical trial. Sertraline 0-10 interleukin 6 Homo sapiens 36-49 24402666-2 2013 This inflammatory action is mediated by suppressive cytokines (i.e. IL-6, TNF-, INF-) inhibiting differentiation and proliferation activities of erythroid cells in the EPO-indipendent phase of erythropoiesis and stimulating hepcidin production for iron retention in reticulo-endothelial system and enterocytes. Iron 248-252 interleukin 6 Homo sapiens 68-85 24045679-8 2013 RESULTS: Silibinin suppressed the growth of HMC-1 cells and also reduced the production and mRNA expression of pro-inflammatory cytokines such as TNF-alpha, IL-6, and IL-8. Silybin 9-18 interleukin 6 Homo sapiens 157-161 23958972-1 2013 The immunotoxicity of the synthetic pyrethroid alpha-cypermethrin (alphaCYP) was assessed in 30 occupationally exposed greenhouse workers and 30 non-exposed controls by comparing plasma levels of IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, TNF-alpha, TNF-beta and INF-gamma. cypermethrin 47-65 interleukin 6 Homo sapiens 224-228 23871825-6 2013 Depending on the treatment received, a distinct inflammatory and oxidative stress profile was observed: in Rivastigmine-treated group, IL6 levels were 47% lower than the average value of the remaining AD patients; homocysteine and glutathione reductase were statistically unchanged in the Rivastigmine and Donepezil-Memantine, respectively Donepezil group. Rivastigmine 107-119 interleukin 6 Homo sapiens 135-138 23973653-9 2013 PPZ induced cell apoptosis and reduced the secretion of the pro-inflammatory cytokine IL-6 specifically in gastric cancer cells, but had no effect on the epithelia cells. propiconazole 0-3 interleukin 6 Homo sapiens 86-90 24121064-0 2013 Sertraline decreases serum level of interleukin-6 (IL-6) in hemodialysis patients with depression: results of a randomized double-blind, placebo-controlled clinical trial. Sertraline 0-10 interleukin 6 Homo sapiens 51-55 24121064-1 2013 BACKGROUND: This study was designed to assess the effect of sertraline on serum concentrations of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), IL-10 and high-sensitivity C-reactive protein (hs-CRP) of depressed hemodialysis (HD) patients. Sertraline 60-70 interleukin 6 Homo sapiens 98-111 24121064-7 2013 Compared with placebo, serum levels of IL-6 significantly decreased (P<0.01) in the sertraline group at week 12 of the study. Sertraline 87-97 interleukin 6 Homo sapiens 39-43 24121064-12 2013 CONCLUSIONS: Compared with placebo, sertraline significantly decreased serum level of IL-6. Sertraline 36-46 interleukin 6 Homo sapiens 86-90 23860688-7 2013 In addition, we have researched that the overexpressed FOXO3a could specially inhibit the release of TNF-alpha increased by ATP, but the level of IL-6 induced by ATP was not decreased. Adenosine Triphosphate 162-165 interleukin 6 Homo sapiens 146-150 23969038-7 2013 In primary human amniotic epithelial cells, pretreatment with a humanized anti-human IL-6 receptor antibody, tocilizumab, significantly inhibited the production of prostaglandin E2 induced by IL-6. Dinoprostone 164-180 interleukin 6 Homo sapiens 192-196 23860688-6 2013 However, ATP had no effect on the expression of FOXO4 and FOXO6, and EGFR, Akt, and ERK1/2 all involve in the release of interleukin (IL)-6 and tumor necrosis factor-alpha (TNF-alpha) induced by ATP. Adenosine Triphosphate 9-12 interleukin 6 Homo sapiens 121-139 23860688-6 2013 However, ATP had no effect on the expression of FOXO4 and FOXO6, and EGFR, Akt, and ERK1/2 all involve in the release of interleukin (IL)-6 and tumor necrosis factor-alpha (TNF-alpha) induced by ATP. Adenosine Triphosphate 195-198 interleukin 6 Homo sapiens 121-139 24033914-9 2013 Further, nighttime human blood, which contained high physiologic levels of melatonin, decreased expression of Cxcl1, Ccl20, and Il-6 in the PC3 human prostate cancer xenograft tumors. Melatonin 75-84 interleukin 6 Homo sapiens 128-132 24198853-2 2013 This response is largely mediated by immune and bone cells (monocytes/macrophages and osteoclasts, respectively), that in the presence of implant debris (e.g. metal particles and ions), release pro-inflammatory cytokines such as IL-1beta, TNF-alpha, and IL-6. Metals 159-164 interleukin 6 Homo sapiens 254-258 24008207-12 2013 In the therapy effective group, in vitro steroid treatment suppressed the CSF"s IL-6 releasing effect almost completely, whereas in the therapy ineffective group, the IL-6 release was significantly reduced but remained detectable. Steroids 41-48 interleukin 6 Homo sapiens 80-84 24168453-4 2013 Though all fatty acids tested produced changes in the production of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), lipoxin A4 and free radical generation by RWPE-1 and PC-3 cells, there were significant differences in their ability to do so. Fatty Acids 11-22 interleukin 6 Homo sapiens 68-81 24168453-4 2013 Though all fatty acids tested produced changes in the production of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), lipoxin A4 and free radical generation by RWPE-1 and PC-3 cells, there were significant differences in their ability to do so. Fatty Acids 11-22 interleukin 6 Homo sapiens 83-87 24212838-9 2013 The fixed combinations induced an increase in IL-6 expression in the travoprost/timolol group, in which there was also an increase in HLA-DR expression. Timolol 80-87 interleukin 6 Homo sapiens 46-50 24082147-3 2013 SOCS3, the major negative regulator of STAT3, is induced by tyrosine-phosphorylated STAT3 and terminates STAT3 phosphorylation about 2 h after initial exposure of cells to members of the IL-6 family of cytokines by binding cooperatively to the common receptor subunit gp130 and JAKs 1 and 2. Tyrosine 60-68 interleukin 6 Homo sapiens 187-191 24091659-5 2013 Alcohol exposure enhanced acinar cell-specific production of TNFalpha, IL-6, MCP-1 and IL-10, as early as 3 h after LPS, whereas IL-18 and caspase-1 were evident 24 h later. Alcohols 0-7 interleukin 6 Homo sapiens 71-75 24212838-10 2013 CONCLUSIONS: All of the fixed combinations induced a significant reduction in intraocular pressure, and the travoprost/timolol group showed increased expression of the inflammatory markers HLA-DR and interleukin-6. Timolol 119-126 interleukin 6 Homo sapiens 200-213 24097820-6 2013 Mechanistically, we show that IL-6 synergizes with oncogenic Kras to activate the reactive oxygen species detoxification program downstream of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling cascade. Reactive Oxygen Species 82-105 interleukin 6 Homo sapiens 30-34 24063815-2 2013 Interleukin-6 (IL-6), a multifunctional cytokine, could influence conditions of altered glucose metabolism such as insulin resistance in diabetic patients. Glucose 88-95 interleukin 6 Homo sapiens 0-13 24063815-2 2013 Interleukin-6 (IL-6), a multifunctional cytokine, could influence conditions of altered glucose metabolism such as insulin resistance in diabetic patients. Glucose 88-95 interleukin 6 Homo sapiens 15-19 23328992-7 2013 We also found that LPS induced ROS production was more affected than the IL-6 production in the presence of ethanol. Ethanol 108-115 interleukin 6 Homo sapiens 73-77 23944357-4 2013 We found that peimine (0-25 mg/L) significantly inhibited tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-1beta, and increased IL-10 production. verticine 14-21 interleukin 6 Homo sapiens 93-111 23683266-10 2013 CONCLUSIONS: O3A ethyl esters decreased the concentrations of triglycerides, IL-6 and TNF-alpha in patients with well-controlled HIV infection and hypertriglyceridaemia. ethyl esters 17-29 interleukin 6 Homo sapiens 77-81 23135962-5 2013 In AMI group, individuals carrying IL6 -174CC genotype had higher serum triglycerides, VLDL cholesterol and glucose compared to the IL6 -174GG/GC genotype carriers (p < 0.05). Triglycerides 72-85 interleukin 6 Homo sapiens 35-38 24142728-7 2013 The TNF-alpha and IL-6 expression showed a downward trend when the progesterone concentration increased, and there were significant differences among all of the groups (P<0.05). Progesterone 67-79 interleukin 6 Homo sapiens 18-22 23135962-5 2013 In AMI group, individuals carrying IL6 -174CC genotype had higher serum triglycerides, VLDL cholesterol and glucose compared to the IL6 -174GG/GC genotype carriers (p < 0.05). Cholesterol 92-103 interleukin 6 Homo sapiens 35-38 23135962-5 2013 In AMI group, individuals carrying IL6 -174CC genotype had higher serum triglycerides, VLDL cholesterol and glucose compared to the IL6 -174GG/GC genotype carriers (p < 0.05). Glucose 108-115 interleukin 6 Homo sapiens 35-38 24353910-1 2013 The inspection of the mechanisms through which autophagy modulates immunogenic cell death revealed that the autophagic response of cancer cells to reactive oxygen species-dependent endoplasmic reticulum stress suppresses the exposure of calreticulin on the cell surface, the phenotypic maturation of dendritic cells (DCs) as well as their ability to release interleukin-6 and to support the proliferative expansion of (interferon gamma-producing) CD4+ and CD8+ T lymphocytes. Reactive Oxygen Species 147-170 interleukin 6 Homo sapiens 358-371 24358684-6 2013 Vitamin D inhibits IL-6, IL-17 and IL-23 secretions which are crucial in Th1 and Th17 differentiation and also decreases proinflammatorical cytokine production. Vitamin D 0-9 interleukin 6 Homo sapiens 19-23 24273488-7 2013 CONCLUSION: Heparin can significantly enhance the stimulating effects of a combination of TPO, SCF, FL, IL-6, and IL-11 supplemented with autologous serum on CFU-MK, MK, and platelet production from CB CD34+ cells. Heparin 12-19 interleukin 6 Homo sapiens 104-108 23831394-5 2013 Troglitazone (10 muM) and L-165,041 (1 muM) significantly inhibited high glucose (25mM)-induced interleukin-6 and TNF-alpha production, RAGE expression and NF-kappaB translocation in HEK cells. Glucose 73-80 interleukin 6 Homo sapiens 96-109 25191580-3 2013 The aim of the present study was to compare the acute effect of meals rich in casein and carbohydrate and a combination of both nutrients on postprandial plasma concentrations of IL-6, a marker of inflammation, in obese women. Carbohydrates 89-101 interleukin 6 Homo sapiens 179-183 24086524-4 2013 RESULTS: Expression array analysis revealed massive upregulation of genes encoding stress-responsive proteins (HSPA1L, EGR1, IL-6, IL-1beta, TNSF10 and TNFalpha) in the styrene-exposed group; the levels of cytokines released were further confirmed in serum. Styrene 169-176 interleukin 6 Homo sapiens 125-129 24086524-6 2013 EGR1 gene upregulation paralleled the expression and transcriptional protein levels of IL-6, TNSF10 and TNFalpha in styrene exposed workers, even at low level. Styrene 116-123 interleukin 6 Homo sapiens 87-91 24049670-0 2013 The role of calcium, NF-kappaB and NFAT in the regulation of CXCL8 and IL-6 expression in Jurkat T-cells. Calcium 12-19 interleukin 6 Homo sapiens 71-75 24049670-6 2013 Interestingly, NF-kappaB activation by heat killed E. coli, as well as CXCL8 and IL-6 expression was significantly suppressed following addition of the calcium ionophore. Calcium 152-159 interleukin 6 Homo sapiens 81-85 22748497-5 2013 In contrast, resveratrol decreased the expression of pro-inflammatory genes IL-6 (interleukin-6) and MCP-1 (monocyte chemoattractant protein-1). Resveratrol 13-24 interleukin 6 Homo sapiens 76-80 22748497-5 2013 In contrast, resveratrol decreased the expression of pro-inflammatory genes IL-6 (interleukin-6) and MCP-1 (monocyte chemoattractant protein-1). Resveratrol 13-24 interleukin 6 Homo sapiens 82-95 23782265-5 2013 Both naringenin and flavone also effectively suppressed IL-6-stimulated phosphorylation of STAT3 (Tyr705) which led to suppression of IL-6-induction of the atherogenic STAT3 target gene MCP1 (monocyte chemotactic protein-1), suggesting that their ability to induce SOCS3 gene expression is STAT3-independent. naringenin 5-15 interleukin 6 Homo sapiens 56-60 23782265-5 2013 Both naringenin and flavone also effectively suppressed IL-6-stimulated phosphorylation of STAT3 (Tyr705) which led to suppression of IL-6-induction of the atherogenic STAT3 target gene MCP1 (monocyte chemotactic protein-1), suggesting that their ability to induce SOCS3 gene expression is STAT3-independent. naringenin 5-15 interleukin 6 Homo sapiens 134-138 23782265-5 2013 Both naringenin and flavone also effectively suppressed IL-6-stimulated phosphorylation of STAT3 (Tyr705) which led to suppression of IL-6-induction of the atherogenic STAT3 target gene MCP1 (monocyte chemotactic protein-1), suggesting that their ability to induce SOCS3 gene expression is STAT3-independent. flavone 20-27 interleukin 6 Homo sapiens 56-60 23469836-4 2013 Increased levels of ROS stimulate proinflammatory gene transcription and release of cytokines, such as IL-1, IL-6, and TNF-alpha, and chemokines, thereby inducing neuroinflammation. Reactive Oxygen Species 20-23 interleukin 6 Homo sapiens 109-113 23782265-5 2013 Both naringenin and flavone also effectively suppressed IL-6-stimulated phosphorylation of STAT3 (Tyr705) which led to suppression of IL-6-induction of the atherogenic STAT3 target gene MCP1 (monocyte chemotactic protein-1), suggesting that their ability to induce SOCS3 gene expression is STAT3-independent. flavone 20-27 interleukin 6 Homo sapiens 134-138 23832664-0 2013 HOXB13 mediates tamoxifen resistance and invasiveness in human breast cancer by suppressing ERalpha and inducing IL-6 expression. Tamoxifen 16-25 interleukin 6 Homo sapiens 113-117 23661232-0 2013 Inhibitory effects of resveratrol on MCP-1, IL-6, and IL-8 production in human coronary artery smooth muscle cells. Resveratrol 22-33 interleukin 6 Homo sapiens 44-48 23142150-3 2013 In particular, protein levels of Tumor Necrosis Factor (TNF) and the SNPs rs1126757 in interleukin-11 (IL11), and rs7801617 in interleukin-6 (IL6), have previously been implicated in the clinical response to the selective serotonin reuptake inhibitor (SSRI) antidepressant escitalopram. Serotonin 222-231 interleukin 6 Homo sapiens 127-140 23631864-10 2013 SN79 also attenuated METH-induced mRNA increases in IL-6 pro-inflammatory cytokine family members. Methamphetamine 21-25 interleukin 6 Homo sapiens 52-56 23743397-3 2013 In nontendon tissue, IL-6 is upregulated in the presence of cyclooxygenase inhibitors and may contribute to alterations in extracellular matrix turnover, possibly due to inhibition of prostaglandin E2 (PGE2). Dinoprostone 184-200 interleukin 6 Homo sapiens 21-25 23743397-3 2013 In nontendon tissue, IL-6 is upregulated in the presence of cyclooxygenase inhibitors and may contribute to alterations in extracellular matrix turnover, possibly due to inhibition of prostaglandin E2 (PGE2). Dinoprostone 202-206 interleukin 6 Homo sapiens 21-25 23822977-5 2013 METHODS: Placental explants were cultured with interleukin-6 (IL-6) in varied concentrations of calcium. Calcium 96-103 interleukin 6 Homo sapiens 47-60 23822977-5 2013 METHODS: Placental explants were cultured with interleukin-6 (IL-6) in varied concentrations of calcium. Calcium 96-103 interleukin 6 Homo sapiens 62-66 23822977-8 2013 RESULTS: Raising the levels of calcium did not prevent the IL-6-induced shedding of NTD from placental explants but did prevent the activation of endothelial cells in response to IL-6, preeclamptic sera, or NTD. Calcium 31-38 interleukin 6 Homo sapiens 179-183 23661232-6 2013 Resveratrol significantly decreased both basal and interferon-gamma (IFN-gamma) (200 ng/ml)-stimulated levels of MCP-1, IL-6, and IL-8 and significantly attenuated both basal and IFN-gamma-stimulated activity of ERK. Resveratrol 0-11 interleukin 6 Homo sapiens 120-124 23661232-8 2013 Therefore, resveratrol is thought to inhibit production of MCP-1, IL-6, and IL-8 in HCASMCs through attenuating ERK activity. Resveratrol 11-22 interleukin 6 Homo sapiens 66-70 24308236-7 2013 Furthermore, high IL-6 producer genotypes (GG or GC) were more frequent in controls than in CaP group (86.7% vs 80.8%, respectively, p = 0.147). cap 92-95 interleukin 6 Homo sapiens 18-22 23553622-0 2013 Tanshinone IIA inhibits breast cancer stem cells growth in vitro and in vivo through attenuation of IL-6/STAT3/NF-kB signaling pathways. tanshinone 0-10 interleukin 6 Homo sapiens 100-104 24062607-10 2013 Isoflavone led to a stronger descent of the concentration of ALP and a decrease of IL-6 and TNF-alpha level than placebo. Isoflavones 0-10 interleukin 6 Homo sapiens 83-87 24062607-11 2013 For climacteric women, soy isoflavone in the dose of 90 mg/day could improve some menopausal syndromes and was effective on increasing limb bone density, which maybe had the relationship with the levels of IL-6, TNF-alpha and ALP in serum. Isoflavones 27-37 interleukin 6 Homo sapiens 206-210 23180154-7 2013 Thiol redox status (GSHtotal-2GSSG/GSSG) increased by >50% after alphaLA and exercise (ANOVA, P < 0.05) and correlated with changes in cytokines interleukin-6 (IL-6) (r = -0.478, P < 0.05) and IL-10 (r = -0.455, P < 0.05). Sulfhydryl Compounds 0-5 interleukin 6 Homo sapiens 151-164 23180154-7 2013 Thiol redox status (GSHtotal-2GSSG/GSSG) increased by >50% after alphaLA and exercise (ANOVA, P < 0.05) and correlated with changes in cytokines interleukin-6 (IL-6) (r = -0.478, P < 0.05) and IL-10 (r = -0.455, P < 0.05). Sulfhydryl Compounds 0-5 interleukin 6 Homo sapiens 166-170 23661232-5 2013 Basal levels of monocyte chemoattractant protein-1 (MCP-1), interleukin (IL)-6, and IL-8 were significantly decreased in the presence of resveratrol at 1-50 muM in a concentration-dependent manner and were significantly decreased in the presence of U0126, an ERK inhibitor. Resveratrol 137-148 interleukin 6 Homo sapiens 60-78 23601055-0 2013 Interleukin-6 is associated with noninvasive markers of liver fibrosis in HIV-infected patients with alcohol problems. Alcohols 101-108 interleukin 6 Homo sapiens 0-13 23791923-7 2013 Furthermore, based on interference with IL-6 secretion, we show potential (chemical) interactions between dexamethasone and sugammadex. Dexamethasone 106-119 interleukin 6 Homo sapiens 40-44 21997325-9 2013 "In vitro" results demonstrate that glucose directly and significantly induced MCP-1 and IL6 and reduced TLR2 mRNA expression. Glucose 36-43 interleukin 6 Homo sapiens 89-92 21997325-10 2013 Insulin at high dose (100 IU/ml) dramatically enhanced the upregulatory effects of glucose on MCP-1 and IL-6 and reduced per se TLR2 mRNA expression. Glucose 83-90 interleukin 6 Homo sapiens 104-108 23601055-11 2013 IL-6 was strongly and significantly associated with liver fibrosis in a cohort of HIV-infected patients with alcohol problems. Alcohols 109-116 interleukin 6 Homo sapiens 0-4 23526220-3 2013 However, drug resistance often develops through several mechanisms during the treatment course, including one mechanism mediated by the activation of the IL-6/signal transducer and activator of transcription (STAT)-3 pathway, related to the generation of reactive oxygen species (ROS). Reactive Oxygen Species 255-278 interleukin 6 Homo sapiens 154-158 23659985-12 2013 Finally, metformin dose-dependently reduced TNF-alpha-induced IL-6 and IkappaBalpha levels in cultured placental JAR cells. Metformin 9-18 interleukin 6 Homo sapiens 62-66 23526220-3 2013 However, drug resistance often develops through several mechanisms during the treatment course, including one mechanism mediated by the activation of the IL-6/signal transducer and activator of transcription (STAT)-3 pathway, related to the generation of reactive oxygen species (ROS). Reactive Oxygen Species 280-283 interleukin 6 Homo sapiens 154-158 23526220-8 2013 Metformin also inhibited cisplatin-induced ROS production and autocrine IL-6 secretion in AS2 cells. Metformin 0-9 interleukin 6 Homo sapiens 72-76 23526220-11 2013 This is the first study to demonstrate that metformin suppresses STAT3 activation via LKB1-AMPK-mTOR-independent but ROS-related and autocrine IL-6 production-related pathways. Metformin 44-53 interleukin 6 Homo sapiens 143-147 23644895-10 2013 RESULTS: The mean serum IL-6 levels on the first day in preoperative and intraoperative steroid groups were significantly lower than in control group. Steroids 88-95 interleukin 6 Homo sapiens 24-28 23652277-13 2013 Decreases in plasma IL-6 and bone alkaline phosphatase, and in urinary N-telopeptide, were associated with DC. Deoxycytidine 107-109 interleukin 6 Homo sapiens 20-24 23644895-11 2013 The serum IL-6 levels in preoperative steroid group were lower than the serum levels in the intraoperative steroid group from the end of surgery to the third day after surgery. Steroids 38-45 interleukin 6 Homo sapiens 10-14 23644895-11 2013 The serum IL-6 levels in preoperative steroid group were lower than the serum levels in the intraoperative steroid group from the end of surgery to the third day after surgery. Steroids 107-114 interleukin 6 Homo sapiens 10-14 23764888-5 2013 Arazyme inhibited the secretion of IL-6 and IL-8 due to phorbol 12-myristate 13-acetate and calcium ionophores in human mast cells. Tetradecanoylphorbol Acetate 56-87 interleukin 6 Homo sapiens 35-39 23766431-7 2013 RESULTS: Etidronate, at the lower concentration, significantly increased the expression of interleukin (IL)-6 (p=0.03) and IL-8 (p=0.04). Etidronic Acid 9-19 interleukin 6 Homo sapiens 91-109 22924597-9 2013 The pro-inflammatory markers IL-6 and hs-CRP also decreased considerably with higher vitamin D levels (P < 0 001). Vitamin D 85-94 interleukin 6 Homo sapiens 29-33 23588308-6 2013 In a different group of BMT patients treated with cyclosporine, the magnitude of interaction with IL-6 was underpredicted by threefold. Cyclosporine 50-62 interleukin 6 Homo sapiens 98-102 22614252-4 2013 MC3T3-E1 osteoblasts showed increased proliferation and decreased differentiation on titanium-nitride, while cytokine interleukin-6 production was higher on porous cobalt-chromium-molybdenum (p < 0.05), though interleukin-1beta was occasionally detected on both surfaces. cobalt-chromium-molybdenum 164-190 interleukin 6 Homo sapiens 118-131 23030238-8 2013 LPS-induced IL-6, IL-1beta, and BLC expression was attenuated in human monocytes treated with estrogen and progesterone. Progesterone 107-119 interleukin 6 Homo sapiens 12-16 23030238-9 2013 Downregulation of IL-6 expression by estrogen and progesterone was potentiated when vitamin D was included. Progesterone 50-62 interleukin 6 Homo sapiens 18-22 23030238-9 2013 Downregulation of IL-6 expression by estrogen and progesterone was potentiated when vitamin D was included. Vitamin D 84-93 interleukin 6 Homo sapiens 18-22 23030238-10 2013 LPS-induced IL-6 and RANTES expression was decreased, and BLC expression was totally reversed, by vitamin D treatment. Vitamin D 98-107 interleukin 6 Homo sapiens 12-16 23823704-0 2013 Oroxylin A inhibits colitis-associated carcinogenesis through modulating the IL-6/STAT3 signaling pathway. 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one 0-10 interleukin 6 Homo sapiens 77-81 23823704-9 2013 RESULTS: Oroxylin A effectively inhibited IL-6/STAT3 pathway in human HCT-116 cells, and the effect of oroxylin A was reversible. 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one 9-19 interleukin 6 Homo sapiens 42-46 23764888-5 2013 Arazyme inhibited the secretion of IL-6 and IL-8 due to phorbol 12-myristate 13-acetate and calcium ionophores in human mast cells. Calcium 92-99 interleukin 6 Homo sapiens 35-39 23562973-7 2013 ATRA consistently and significantly inhibited LPS-induced release of the pro-inflammatory cytokines tumor necrosis factor, interleukin (IL)-6, macrophage inflammatory protein (MIP)-1alpha and MIP-1beta. Tretinoin 0-4 interleukin 6 Homo sapiens 123-141 23767858-7 2013 In multiple regression analysis, postload glucose concentration was independently associated with circulating hsCRP and IL-6 concentrations when the data was controlled for age, gender, BMI and lipid concentrations (p < 0.05 for hsCRP, and IL-6). Glucose 42-49 interleukin 6 Homo sapiens 120-124 23767858-7 2013 In multiple regression analysis, postload glucose concentration was independently associated with circulating hsCRP and IL-6 concentrations when the data was controlled for age, gender, BMI and lipid concentrations (p < 0.05 for hsCRP, and IL-6). Glucose 42-49 interleukin 6 Homo sapiens 243-247 23602849-6 2013 We show here that the activity of sbIL-6P was significantly induced by pro-inflammatory cytokines such as tumor necrosis factor alpha (TNFalpha), IL-6 and IL-2, as well as by lipopolysaccharide (LPS), but significantly repressed by dexamethasone. Dexamethasone 232-245 interleukin 6 Homo sapiens 36-40 24416568-11 2013 The level of IL-6 assessed before the surgery was significantly correlated with survival times such as OS (p = 0.0096) and CSS (p = 0.0002). Osmium 103-105 interleukin 6 Homo sapiens 13-17 24416568-13 2013 CONCLUSIONS: Results of our study showed that elevated levels of IL-6 and CRP in peripheral blood before surgery of RCC were correlated with worse OS and CSS. Osmium 147-149 interleukin 6 Homo sapiens 65-69 23735697-0 2013 High glucose modulates IL-6 mediated immune homeostasis through impeding neutrophil extracellular trap formation. Glucose 5-12 interleukin 6 Homo sapiens 23-27 23639249-4 2013 Activation of STAT3, which is phosphorylated by the IL-6 signaling pathways and thus is necessary for Th17 differentiation, was strongly stimulated by I3S and TCDD. Polychlorinated Dibenzodioxins 159-163 interleukin 6 Homo sapiens 52-56 22926083-0 2013 Elevated ratio of arachidonic acid to long-chain omega-3 fatty acids predicts depression development following interferon-alpha treatment: relationship with interleukin-6. Arachidonic Acid 18-34 interleukin 6 Homo sapiens 157-170 23844973-0 2013 Resveratrol, a sirtuin 1 activator, increases IL-6 production by peripheral blood mononuclear cells of patients with knee osteoarthritis. Resveratrol 0-11 interleukin 6 Homo sapiens 46-50 23844973-8 2013 After resveratrol treatment, no changes in TNFalpha or IL-8 levels were found, but a significant dose-dependent increase in IL-6 levels was demonstrated in patients with osteoarthritis, but not controls. Resveratrol 6-17 interleukin 6 Homo sapiens 124-128 23844973-11 2013 Ex vivo treatment of peripheral blood mononuclear cells with resveratrol was associated with a dose-dependent increase in IL-6 levels only in patients with osteoarthritis. Resveratrol 61-72 interleukin 6 Homo sapiens 122-126 23564015-4 2013 Our results indicated that murrayafoline A derivatives containing 1,2,3-triazole nucleus potentially possessed anti-inflammatory action through inhibiting production of IL-6, IL-12 p40 and TNF-alpha. Triazoles 66-80 interleukin 6 Homo sapiens 169-173 23583258-3 2013 This report concerns the marked up-regulation in differentiated CaCo-2 colonic epithelial cells of two key inflammatory interleukins, IL-6 and IL-8, caused by a mixture of oxysterols representative of a high cholesterol diet. Cholesterol 208-219 interleukin 6 Homo sapiens 134-138 23693076-11 2013 Furthermore, high glucose increased the secretion of IL-6 and ICAM, as well as decreased phospho-eNOS protein expression and NOS activity. Glucose 18-25 interleukin 6 Homo sapiens 53-57 23889483-7 2013 Vitamin D treatment in vitro has also been demonstrated to modulate levels of the systemic inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6), as well as inhibit the lipopolysaccharide (LPS)-induced activation and vasodilation of vascular endothelium. Vitamin D 0-9 interleukin 6 Homo sapiens 167-180 23889483-7 2013 Vitamin D treatment in vitro has also been demonstrated to modulate levels of the systemic inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6), as well as inhibit the lipopolysaccharide (LPS)-induced activation and vasodilation of vascular endothelium. Vitamin D 0-9 interleukin 6 Homo sapiens 182-186 23324897-4 2013 Both atorvastatin and vitamin E showed a statistically significant GPO increase (P<0.05) and a statistically significant IL-6 decrease (P<0.05). Atorvastatin 5-17 interleukin 6 Homo sapiens 124-128 23625043-6 2013 RESULTS: Periodic high glucose caused a more intense inflammatory response than normal glucose and constant high glucose in HCAECs, with a marked increase in IL-6, TNF-alpha and ICAM-1 in supernatants of cell culture (P < 0.05). Glucose 23-30 interleukin 6 Homo sapiens 158-162 23624824-8 2013 Importantly, pretreatment of PC12 cells with exogenous application of sodium hydrosulfide (a H2S donor, 400 mumol/l) for 30 min before exposure to CoCl2 markedly attenuated chemical hypoxia-stimulated iNOS and nNOS expression, NO generation and IL-6 secretion as well as p38MAPK phosphorylation in PC12 cells. sodium bisulfide 70-89 interleukin 6 Homo sapiens 245-249 24152848-3 2013 IL-6R-alpha also exists as soluble protein (sIL-6R) that, in the presence of IL-6, forms a complex able to bind gp130 and, thanks to the mechanism called trans-signaling, transduces IL-6 effect through tyrosine phosphorylation and activation of the signal transducer and transcription activator (STAT)-3. Tyrosine 202-210 interleukin 6 Homo sapiens 0-4 24152848-3 2013 IL-6R-alpha also exists as soluble protein (sIL-6R) that, in the presence of IL-6, forms a complex able to bind gp130 and, thanks to the mechanism called trans-signaling, transduces IL-6 effect through tyrosine phosphorylation and activation of the signal transducer and transcription activator (STAT)-3. Tyrosine 202-210 interleukin 6 Homo sapiens 45-49 23511701-6 2013 RESULTS: Baseline serum IL-6 showed significant negative correlations with lumbar BMD and handgrip strength (r = -0.458, P = 0.01, and left hand; r = -0.387, P = 0.03, respectively), whereas serum 25-hydroxy vitamin D level was 13.97 (5.65) ng/mL, compatible with vitamin D insufficiency and inversely correlated with PTH level (r = -0.481, P = 0.005). Vitamin D 208-217 interleukin 6 Homo sapiens 24-28 23511701-6 2013 RESULTS: Baseline serum IL-6 showed significant negative correlations with lumbar BMD and handgrip strength (r = -0.458, P = 0.01, and left hand; r = -0.387, P = 0.03, respectively), whereas serum 25-hydroxy vitamin D level was 13.97 (5.65) ng/mL, compatible with vitamin D insufficiency and inversely correlated with PTH level (r = -0.481, P = 0.005). Vitamin D 264-273 interleukin 6 Homo sapiens 24-28 23980418-0 2013 Formal synthesis of (+)-madindoline A, a potent IL-6 inhibitor, utilizing enzymatic discrimination of quaternary carbon. Carbon 113-119 interleukin 6 Homo sapiens 48-52 23280522-7 2013 Testosterone also decreased TNF-alpha and IL6 production by pSMCs after LPS as quantified by ELISA. Testosterone 0-12 interleukin 6 Homo sapiens 42-45 23475986-8 2013 Although naringenin significantly attenuated IL-1beta-induced IL-6 and IL-8 mRNA expression and release, there was no effect of curcumin and apigenin. naringenin 9-19 interleukin 6 Homo sapiens 62-66 23791132-7 2013 In VTE patients atorvastatin decreased IL-6 (p=0.0003), IL-8 (p=0.003) and P-selectin (p<0.0001), but increased IL-10 (p=0.001), with no association with C-reactive protein or cholesterol-lowering effects. Atorvastatin 16-28 interleukin 6 Homo sapiens 39-43 23791132-8 2013 Atorvastatin reduced IL-1b (p=0.01), IL-6 (p=0.03) and P-selectin (p=0.002) in controls. Atorvastatin 0-12 interleukin 6 Homo sapiens 37-41 23371411-2 2013 Therefore, this study was aimed to investigate the association between concentration of IL-6 in relation to glucose control, lipid profile, and body mass index (BMI) in 69 DM1 patients subdivided according to the absence or presence of microvascular complications. Glucose 108-115 interleukin 6 Homo sapiens 88-92 23656327-4 2013 Specifically, a subset of compounds bearing phenyl and substituted phenyl carboxamides induced lower IL-6 release while maintaining higher IP-10 production, skewing toward the type I interferon pathway. benzamide 67-86 interleukin 6 Homo sapiens 101-105 23776669-1 2013 BACKGROUND: Plasma interleukin-6 (IL-6) concentrations decrease acutely 1 h after ingestion of a glucose load or mixed meals and this may be mediated by an anti-inflammatory effect of insulin. Glucose 97-104 interleukin 6 Homo sapiens 19-32 23776669-1 2013 BACKGROUND: Plasma interleukin-6 (IL-6) concentrations decrease acutely 1 h after ingestion of a glucose load or mixed meals and this may be mediated by an anti-inflammatory effect of insulin. Glucose 97-104 interleukin 6 Homo sapiens 34-38 23776669-6 2013 Plasma IL-6 decreased (13-20%) significantly (P = 0.009) at 30 min to 90 min following the oral glucose load and did not change significantly following the other two interventions. Glucose 96-103 interleukin 6 Homo sapiens 7-11 23776669-7 2013 The incremental area under the curve for plasma IL-6 concentrations following oral intake of glucose was significantly lower compared with concentrations following intravenous glucose (P = 0.005) and water control (P = 0.02). Glucose 93-100 interleukin 6 Homo sapiens 48-52 23749899-8 2013 Under treatment with low concentrations of 5-fluorouracil and cisplatin, all examined cell lines showed an increasing secretion of the cytokines IL-6 and G-CSF. Fluorouracil 43-57 interleukin 6 Homo sapiens 145-149 23749899-8 2013 Under treatment with low concentrations of 5-fluorouracil and cisplatin, all examined cell lines showed an increasing secretion of the cytokines IL-6 and G-CSF. Cisplatin 62-71 interleukin 6 Homo sapiens 145-149 23806369-8 2013 With knockdown of LSD1, H3K4 methylation at IL-6 promoter was found increased after TPA treatment at different times points (all P<0.05, except 24 hours). Tetradecanoylphorbol Acetate 84-87 interleukin 6 Homo sapiens 44-48 23511931-6 2013 Interestingly, polyP-induced NF-kappaB activation and the production of TNF-alpha and IL-6 were inhibited by low thrombin concentrations in HUVECs. Polyphosphates 15-20 interleukin 6 Homo sapiens 86-90 23537666-7 2013 The difference in gene expression dynamics was associated with differential activation of hub genes and molecular signaling pathways related to calcium signaling (CREB), inflammation (TNFalpha, NFkB, and IL6) and bone development (TGFbeta, beta-catenin, BMP, EGF, and ERK signaling). Calcium 144-151 interleukin 6 Homo sapiens 204-207 23771534-0 2013 MIF attenuates the suppressive effect of dexamethasone on IL-6 production by nasal polyp. Dexamethasone 41-54 interleukin 6 Homo sapiens 58-62 23771534-4 2013 AIM: To investigate the presence of MIF in nasal polyp tissues and the influence of a MIF activity inhibitor on dexamethasone effects on IL-6 production. Dexamethasone 112-125 interleukin 6 Homo sapiens 137-141 23771534-10 2013 Dexamethasone at concentration 1-100 microM caused a statistically significant dose-dependent suppression of IL-6 production by polyp tissue cultures. Dexamethasone 0-13 interleukin 6 Homo sapiens 109-113 23771534-12 2013 CONCLUSIONS: MIF, presence in polyp tissue, attenuates the suppressive effect of dexamethasone on the production of IL-6 by this tissue, since the simultaneous use of its inhibitor ISO-1 leads to an enhancement of dexamethasone activity. Dexamethasone 81-94 interleukin 6 Homo sapiens 116-120 23371411-4 2013 In DM1 patients, IL-6 concentration was positively correlated with level of FPG, LDL-C, TCH concentrations, and BMI. thiocarbohydrazide 88-91 interleukin 6 Homo sapiens 17-21 23611575-2 2013 The administration of metformin reduced pain intensity from 9/10 to 3/10 and favorably affected the profile of inflammatory cytokines (i.e., TNF a, IL-1beta, IL-6, and IL-10), adipokines (i.e., adiponectin, leptin, and resistin), and beta-endorphin. Metformin 22-31 interleukin 6 Homo sapiens 158-162 23730211-6 2013 Furthermore, curcumin suppressed the expression/secretion of stromal cell-derived factor-1 (SDF-1), interleukin-6 (IL-6), matrix metalloproteinase-2 (MMP-2), MMP-9, and transforming growth factor-beta, which impeded their paracrine procarcinogenic potential. Curcumin 13-21 interleukin 6 Homo sapiens 100-113 24149807-5 2013 The pro-inflammatory cytokines IL-1beta and TNFalpha decreased, whereas anti-inflammatory cytokines IL-6 and IL-10 increased after 3d rest and 14d camp. Cyclic AMP 147-151 interleukin 6 Homo sapiens 100-104 22351517-6 2013 TPA treatment also elevates levels of c-jun (AP-1 component), cyclooxygenase-2 (COX-2), p50 (NF-kappaB component), interleukin-6 (IL-6), and tumor necrosis factor (TNF) in the skin. Tetradecanoylphorbol Acetate 0-3 interleukin 6 Homo sapiens 115-128 22351517-6 2013 TPA treatment also elevates levels of c-jun (AP-1 component), cyclooxygenase-2 (COX-2), p50 (NF-kappaB component), interleukin-6 (IL-6), and tumor necrosis factor (TNF) in the skin. Tetradecanoylphorbol Acetate 0-3 interleukin 6 Homo sapiens 130-134 23504962-7 2013 Also, quercetin and quercetin-3-O-glucuronide inhibited ROS-associated inflammation by inhibition of interleukin-6 and tumor necrosis factor-alpha production with suppression of IKKbeta/NF-kappaB phosphorylation. quercetin 3-O-glucuronide 20-45 interleukin 6 Homo sapiens 101-146 23504962-7 2013 Also, quercetin and quercetin-3-O-glucuronide inhibited ROS-associated inflammation by inhibition of interleukin-6 and tumor necrosis factor-alpha production with suppression of IKKbeta/NF-kappaB phosphorylation. Reactive Oxygen Species 56-59 interleukin 6 Homo sapiens 101-146 23730211-6 2013 Furthermore, curcumin suppressed the expression/secretion of stromal cell-derived factor-1 (SDF-1), interleukin-6 (IL-6), matrix metalloproteinase-2 (MMP-2), MMP-9, and transforming growth factor-beta, which impeded their paracrine procarcinogenic potential. Curcumin 13-21 interleukin 6 Homo sapiens 115-119 24278066-6 2013 RESULTS: Serum levels of IL-6 and CRP were significantly higher in patients with CU compared to healthy controls (p < 0.001, p = 0.026 respectively). Copper 81-83 interleukin 6 Homo sapiens 25-29 23583378-4 2013 We found that IL-6-dependent induction of tyrosine phosphorylation and activation of STAT3 were influenced by nm23-H1 inhibition. Tyrosine 42-50 interleukin 6 Homo sapiens 14-18 23665025-6 2013 Interleukin-6 (IL-6) could induce STAT3 activation in cisplatin-sensitive ovarian cancer cells and led to protection against cisplatin. Cisplatin 54-63 interleukin 6 Homo sapiens 0-13 23665025-6 2013 Interleukin-6 (IL-6) could induce STAT3 activation in cisplatin-sensitive ovarian cancer cells and led to protection against cisplatin. Cisplatin 54-63 interleukin 6 Homo sapiens 15-19 23665025-6 2013 Interleukin-6 (IL-6) could induce STAT3 activation in cisplatin-sensitive ovarian cancer cells and led to protection against cisplatin. Cisplatin 125-134 interleukin 6 Homo sapiens 0-13 23665025-6 2013 Interleukin-6 (IL-6) could induce STAT3 activation in cisplatin-sensitive ovarian cancer cells and led to protection against cisplatin. Cisplatin 125-134 interleukin 6 Homo sapiens 15-19 23698162-3 2013 In summary, dietary fatty acids, in particular saturated fatty acids and the omega-3 and omega-6 polyunsaturated fatty acids, impact the expression of the cytokine genes TNFA and IL-6, and alter TNFalpha and IL-6 production. Fatty Acids 47-68 interleukin 6 Homo sapiens 179-183 23698162-3 2013 In summary, dietary fatty acids, in particular saturated fatty acids and the omega-3 and omega-6 polyunsaturated fatty acids, impact the expression of the cytokine genes TNFA and IL-6, and alter TNFalpha and IL-6 production. Fatty Acids 47-68 interleukin 6 Homo sapiens 208-212 23739567-7 2013 The protein expressions of IL-1beta and IL-6 proteins and the mRNA expression of IL-1beta in PDs group were significantly higher than those in PHs group, while the expressions of IL-10 protein and IL-10 mRNA were evidently lowered (all P<0.05). Palladium 93-96 interleukin 6 Homo sapiens 40-44 22839694-8 2013 Serum levels of IL-6 (P = 0.04) and leptin (P = 0.01) were correlated with the OCP group, with odds ratios of 0.99 (95% confidence interval [CI]: -0.01 to -0.00) and 0.99 (95% CI: -0.00 to -0.00), respectively. 5,10,15,20-tetra(3,5-(nido-carboranylmethyl)phenyl)porphyrin 79-82 interleukin 6 Homo sapiens 16-20 23303450-3 2013 HSF showed increased Tyr 705 STAT3 phosphorylation compared with normal fibroblast (NF) after IL-6 IL-6Ralpha stimulation by immunoassays. Tyrosine 21-24 interleukin 6 Homo sapiens 0-3 23462222-2 2013 Elevated levels of interleukin-6 (IL-6) in patients are associated with increased morbidity and mortality after injury, and high systemic and pulmonary levels of IL-6 have been observed after the combined insult of ethanol exposure and burn injury. Ethanol 215-222 interleukin 6 Homo sapiens 162-166 23850671-5 2013 Concentration of IL-6 and hepcidin increased 1h after exercise in both groups (p<0.05). Hydrogen 45-47 interleukin 6 Homo sapiens 17-21 23681030-16 2013 Dexamethasone use significantly reduced postoperative levels of C-reactive protein (P = .01) and interleukin 6 and interleukin 1beta (P = .02), fatigue (P = .01), and overall pain during the first 24 postoperative hours (P = .04), as well as the total analgesic (ketorolac tromethamine) requirement (P = .04). Dexamethasone 0-13 interleukin 6 Homo sapiens 97-110 23488692-9 2013 Furthermore, NS-398 reduced the production of IL-6 and IL-8, thus indicating that IL-1beta/HMGB1 complexes modulate cytokine production in part through prostanoid synthesis. Prostaglandins 152-162 interleukin 6 Homo sapiens 46-50 23490068-0 2013 Prostaglandin E2 induces transcription of skeletal muscle mass regulators interleukin-6 and muscle RING finger-1 in humans. Dinoprostone 0-16 interleukin 6 Homo sapiens 74-112 23490068-2 2013 Initial evidence suggests a potential mechanism of COX inhibitor blunted prostaglandin (PG) E2 stimulation of interleukin (IL)-6 and the ubiquitin ligase MuRF-1, reducing their inhibition on muscle growth. Dinoprostone 73-94 interleukin 6 Homo sapiens 110-128 23490068-3 2013 The purpose of this investigation was to determine if PGE2 stimulates IL-6 and MuRF-1 transcription in skeletal muscle. Dinoprostone 54-58 interleukin 6 Homo sapiens 70-74 23490068-5 2013 PGE2 upregulated (P<0.05) expression of both IL-6 (195%) and MuRF-1 (51%). Dinoprostone 0-4 interleukin 6 Homo sapiens 48-52 23490068-6 2013 A significant relationship was found between IL-6 and MuRF-1 expression after incubation with PGE2 (r=0.77, P<0.05), suggesting regulation through a common pathway. Dinoprostone 94-98 interleukin 6 Homo sapiens 45-49 23490068-7 2013 PGE2 induces IL-6 and MuRF-1 transcription in human skeletal muscle, providing a mechanistic link between COX inhibiting drugs, PGE2, and the regulation of muscle mass. Dinoprostone 0-4 interleukin 6 Homo sapiens 13-17 23490068-7 2013 PGE2 induces IL-6 and MuRF-1 transcription in human skeletal muscle, providing a mechanistic link between COX inhibiting drugs, PGE2, and the regulation of muscle mass. Dinoprostone 128-132 interleukin 6 Homo sapiens 13-17 23741643-10 2013 A significant (p < 0.05) correlation between changes of SR vs IL-6 and ROS was observed. Reactive Oxygen Species 74-77 interleukin 6 Homo sapiens 65-69 23396138-0 2013 AhR- and NF-kappaB-dependent induction of interleukin-6 by co-exposure to the environmental contaminant benzanthracene and the cytokine tumor necrosis factor-alpha in human mammary MCF-7 cells. benz(a)anthracene 104-118 interleukin 6 Homo sapiens 42-55 23396138-3 2013 Co-exposure to the prototypical PAH benzanthracene (BZA) and TNF-alpha was found to markedly induce mRNA expression and secretion of IL-6 in human breast cancer cells MCF-7, whereas exposure to either BZA or TNF-alpha alone was without significant effect. benz(a)anthracene 36-50 interleukin 6 Homo sapiens 133-137 23488631-3 2013 SI, AD, and DM reduced a mean phorbol-12-myristate-13-acetate/ionomycin (PMA/I)-stimulated release of the pro-inflammatory interleukins IL-6 and IL-8 by more than 50% (p < 0.05). Tetradecanoylphorbol Acetate 30-61 interleukin 6 Homo sapiens 136-140 23637886-4 2013 And H(H2O)m significantly prevented UV-induced MMP-1, COX-2, IL-6 and IL-1beta mRNA expressions in human skin in vivo. Water 6-9 interleukin 6 Homo sapiens 61-65 23637886-5 2013 We found that H(H2O)m prevented UV-induced ROS generation and inhibited UV-induced MMP-1, COX-2 and IL-6 expressions, and UV-induced JNK and c-Jun phosphorylation in HaCaT cells. Water 16-19 interleukin 6 Homo sapiens 100-104 23637886-7 2013 In intrinsically aged skin, H(H2O)m application significantly reduced constitutive expressions of MMP-1, IL-6, and IL-1beta mRNA. Water 30-33 interleukin 6 Homo sapiens 105-109 23637886-8 2013 Additionally, H(H2O)m significantly increased procollagen mRNA and also decreased MMP-1 and IL-6 mRNA expressions in photoaged facial skin. Water 16-19 interleukin 6 Homo sapiens 92-96 23434081-6 2013 IL-6 in piglet plasma of the AAP group (mixed feed concentration of 600 mg/kg) was significantly reduced (P<0.05) at 3h after LPS-challenge as compared with the LPS control group. Tritium 120-122 interleukin 6 Homo sapiens 0-4 23434081-8 2013 The levels of inflammatory cytokines (TNF-alpha, IL-1beta, IL-6, and IL-10) in piglet plasma of the NAC group (mixed feeding concentration of 1200 mg/kg) were significantly lower at 3h after LPS stimulation (P<0.05). Acetylcysteine 100-103 interleukin 6 Homo sapiens 59-63 23436796-4 2013 Treatment with cisplatin or carboplatin increased the potency of tumor cell lines to induce IL-10-producing M2 macrophages, which displayed increased levels of activated STAT3 due to tumor-produced IL-6 as well as decreased levels of activated STAT1 and STAT6 related to the PGE(2) production of tumor cells. Cisplatin 15-24 interleukin 6 Homo sapiens 198-202 23479230-3 2013 Alarmins, such as ATP, likely play a pivotal role in the induction and maintenance of cutaneous immune responses by stimulating DC maturation, chemotaxis, and secretion of IL-1beta and IL-6, Th17-biasing cytokines. Adenosine Triphosphate 18-21 interleukin 6 Homo sapiens 185-189 23488631-3 2013 SI, AD, and DM reduced a mean phorbol-12-myristate-13-acetate/ionomycin (PMA/I)-stimulated release of the pro-inflammatory interleukins IL-6 and IL-8 by more than 50% (p < 0.05). Ionomycin 62-71 interleukin 6 Homo sapiens 136-140 23488631-5 2013 A significant, more than 50% mean inhibition of PMA/I-induced IL-6 and IL-8 release was demonstrated for the volatile compounds 1,8-cineole, borneol, camphor, and thujone, but not for the nonvolatile rosmarinic acid when applied in concentrations representative of sage infusion. isoborneol 141-148 interleukin 6 Homo sapiens 62-66 23488631-5 2013 A significant, more than 50% mean inhibition of PMA/I-induced IL-6 and IL-8 release was demonstrated for the volatile compounds 1,8-cineole, borneol, camphor, and thujone, but not for the nonvolatile rosmarinic acid when applied in concentrations representative of sage infusion. rosmarinic acid 200-215 interleukin 6 Homo sapiens 62-66 23552565-9 2013 Both 3 and 7% sevoflurane decreased TNF-alpha and IL-6 levels at 24 hours (both p<0.05). Sevoflurane 14-25 interleukin 6 Homo sapiens 50-54 23567762-8 2013 Notably, plasma ghrelin levels were independently negatively correlated with plasma TNF-a and IL-6 (P<0.05). Ghrelin 16-23 interleukin 6 Homo sapiens 94-98 23567762-9 2013 CONCLUSIONS: Increased plasma ghrelin levels might constitute an independent determinant of decreased TNF-a and IL-6, suggesting that higher ghrelin level may in part represent a compensatory mechanism to overcome the pro-inflammatory effects of OSA. Ghrelin 30-37 interleukin 6 Homo sapiens 112-116 23552565-11 2013 Both 3% and 7% sevoflurane decreased TNF-alpha and IL-6 levels at 24 hours (both p<0.05). Sevoflurane 15-26 interleukin 6 Homo sapiens 51-55 23552565-12 2013 CONCLUSIONS: Postconditioning with the halogenated anesthetic agent sevoflurane after LPS stimulation shows a cytoprotective effect in an in vitro model, decreasing cell death and reducing TLR2 and TLR4 expression as well as levels of the inflammatory mediators TNF-alpha and IL-6 in human endothelial cells. Sevoflurane 68-79 interleukin 6 Homo sapiens 276-280 23780308-4 2013 EGCG inhibited high glucose(HG)-induced TNF-alpha and IL-6 production in human embryonic kidney (HEK) cells. Glucose 20-27 interleukin 6 Homo sapiens 54-58 23295714-8 2013 RESULTS: Sevoflurane suppressed TNF-alpha-induced IL-6, IL-8, and MCP-1 gene expression and the production of IL-6 and IL-8 in SAEC under anoxia/reoxygenation conditions. Sevoflurane 9-20 interleukin 6 Homo sapiens 50-54 23295714-8 2013 RESULTS: Sevoflurane suppressed TNF-alpha-induced IL-6, IL-8, and MCP-1 gene expression and the production of IL-6 and IL-8 in SAEC under anoxia/reoxygenation conditions. Sevoflurane 9-20 interleukin 6 Homo sapiens 110-114 23339056-9 2013 In addition, steroids significantly reduced postoperative blood levels of bilirubin, and of inflammatory markers such as IL-6 and C-reactive protein. Steroids 13-21 interleukin 6 Homo sapiens 121-125 23295714-12 2013 CONCLUSIONS: Sevoflurane suppressed the NF-kappaB-mediated production of pulmonary epithelial cell-derived inflammatory cytokines, including IL-6 and IL-8, which are capable of causing I/R injury. Sevoflurane 13-24 interleukin 6 Homo sapiens 141-145 24235998-1 2013 BACKGROUND & AIMS: Interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-alpha), two important inflammatory cytokines, have been inconsistently associated with risk of colon neoplasia in epidemiological studies. Adenosine Monophosphate 12-15 interleukin 6 Homo sapiens 23-36 23498057-0 2013 Glutamine and alanine-induced differential expression of intracellular IL-6, IL-8, and TNF-alpha in LPS-stimulated monocytes in human whole-blood. Alanine 14-21 interleukin 6 Homo sapiens 71-75 23498057-8 2013 However, l-alanine had contrary effects on IL-6 expression, significantly upregulating expression of IL-6 in LPS-treated monocytes. Alanine 9-18 interleukin 6 Homo sapiens 43-47 23498057-8 2013 However, l-alanine had contrary effects on IL-6 expression, significantly upregulating expression of IL-6 in LPS-treated monocytes. Alanine 9-18 interleukin 6 Homo sapiens 101-105 23498057-12 2013 For the regulation of TNF-alpha, l-glutamine, l-alanine and the combination of both show a congruent and exponentiated downregulating effect during endotoxemia, for the modulation of IL-6, l-glutamine and l-alanine featured opposite regulation leading to a canceling impact of each other when recombining both amino acids. Alanine 46-55 interleukin 6 Homo sapiens 183-187 23498057-12 2013 For the regulation of TNF-alpha, l-glutamine, l-alanine and the combination of both show a congruent and exponentiated downregulating effect during endotoxemia, for the modulation of IL-6, l-glutamine and l-alanine featured opposite regulation leading to a canceling impact of each other when recombining both amino acids. Alanine 205-214 interleukin 6 Homo sapiens 183-187 23257175-6 2013 Moreover, IL-6 treatment increased NF-kappaB activity in vessels stretched with a mechanical strain of 3 g, and this effect was blocked by stretch-activated channel inhibitors (streptomycin or GdCl3) and the NF-kappaB peptide inhibitor SN50, but not by the inactive SN50 analogue SN50M. Streptomycin 177-189 interleukin 6 Homo sapiens 10-14 24235998-1 2013 BACKGROUND & AIMS: Interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-alpha), two important inflammatory cytokines, have been inconsistently associated with risk of colon neoplasia in epidemiological studies. Adenosine Monophosphate 12-15 interleukin 6 Homo sapiens 38-42 23257175-6 2013 Moreover, IL-6 treatment increased NF-kappaB activity in vessels stretched with a mechanical strain of 3 g, and this effect was blocked by stretch-activated channel inhibitors (streptomycin or GdCl3) and the NF-kappaB peptide inhibitor SN50, but not by the inactive SN50 analogue SN50M. gadolinium chloride 193-198 interleukin 6 Homo sapiens 10-14 23426900-9 2013 The peak concentrations of TNF-alpha and IL-6 were shown to be in concordance with the rhythm of melatonin secretion. Melatonin 97-106 interleukin 6 Homo sapiens 41-45 23103379-7 2013 Meantime, GdCl(3) and Ca(2+) stimulated both the IL-6 and TNF-beta releases and their mRNA expressions. gadolinium chloride 10-17 interleukin 6 Homo sapiens 49-53 23349093-7 2013 It has been experimentally evidenced that metal particles induced higher amounts of IL-6 and IL-1 but very low amounts of TNF-alpha. Metals 42-47 interleukin 6 Homo sapiens 84-88 23433769-9 2013 Significant changes (defined a priori as p < 0.1) in favour of AZD9668 were also seen in slow vital capacity, plasma interleukin-8, and post-waking sputum interleukin-6 and Regulated on Activation, Normal T-cell Expressed and Secreted levels. N-((5-(methanesulfonyl)pyridin-2-yl)methyl)-6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide 66-73 interleukin 6 Homo sapiens 158-171 23012315-6 2013 Vitamin D also attenuated IL-1beta-induced MCP-1, IL-6, connexin 43, cyclooxygenase (COX)-2, and prostaglandin receptor expression. Vitamin D 0-9 interleukin 6 Homo sapiens 50-54 23461851-1 2013 Extracellular ATP and P2 receptors are reported to be involved in interleukin-6 (IL-6) production by human keratinocytes, but the role of extracellular ATP in cytokine-induced IL-6 production remains unclear. Adenosine Triphosphate 14-17 interleukin 6 Homo sapiens 66-79 23506529-3 2013 Aspirin is a non-steroidal anti-inflammatory drug that is an irreversible inhibitor of both cyclooxygenase (COX)-1 and COX-2, It stimulates endogenous production of anti-inflammatory regulatory "braking signals", including lipoxins, which dampen the inflammatory response and reduce levels of inflammatory biomarkers, including C-reactive protein, tumor necrosis factor-alpha and interleukin (IL)--6, but not negative immunoregulatory cytokines, such as IL-4 and IL-10. Aspirin 0-7 interleukin 6 Homo sapiens 380-399 23369747-6 2013 KEY FINDINGS: Compared with the normal glucose group, exposure of HUVECs to 50 mmol/L of glucose or 1000 mug/L of LPS significantly increased the concentrations of TNF-alpha and IL-6 in the culture supernatants. Glucose 89-96 interleukin 6 Homo sapiens 178-182 23461851-1 2013 Extracellular ATP and P2 receptors are reported to be involved in interleukin-6 (IL-6) production by human keratinocytes, but the role of extracellular ATP in cytokine-induced IL-6 production remains unclear. Adenosine Triphosphate 14-17 interleukin 6 Homo sapiens 81-85 23262029-10 2013 Further, over-expression of Sirt1 or treatment with the Sirt1 activator resveratrol blocked the increase in Il-6 transcription by MVNP. Resveratrol 72-83 interleukin 6 Homo sapiens 108-112 23113669-6 2013 CONCLUSIONS: Similarly to the known locally increased IL-6 activity in DPU lesions, the elevated circulating levels of IL-6 and CRP have been currently found in DPU. Mixed Carbamic Phosphoric Acid Anhydride of 7,8-Diaminononanic Acid 71-74 interleukin 6 Homo sapiens 54-58 23161148-8 2013 AG490, PD98059, or LY294002, inhibitors specific for the intracellular signals, JAK, MAPK, and PI3K, respectively, partially blocked these IL-6 neuroprotective effects. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 7-14 interleukin 6 Homo sapiens 139-143 23161148-10 2013 The enhanced activation of STAT3, ERK1/2, and AKT by IL-6 was abolished by AG490, PD98059, and LY294002, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 82-89 interleukin 6 Homo sapiens 53-57 23652186-9 2013 The IL-6 concentrations were associated with TAG, and IL-1beta with HDL-cholesterol concentration, after adjustment by BMI. Cholesterol 72-83 interleukin 6 Homo sapiens 4-8 23600327-5 2013 The constitutive expression of RANKL and Ki-67 and the production of IL-6 and IL-8 were significantly inhibited by Dex treatment. Dexamethasone 115-118 interleukin 6 Homo sapiens 69-73 23600327-6 2013 Further, Dex significantly suppressed the stimulatory effects of LPS on RANKL and Ki-67 expression and on IL-6 and IL-8 production. Dexamethasone 9-12 interleukin 6 Homo sapiens 106-110 23113669-6 2013 CONCLUSIONS: Similarly to the known locally increased IL-6 activity in DPU lesions, the elevated circulating levels of IL-6 and CRP have been currently found in DPU. Mixed Carbamic Phosphoric Acid Anhydride of 7,8-Diaminononanic Acid 161-164 interleukin 6 Homo sapiens 119-131 23480322-12 2013 Iron status was inversely associated with weight gain during risperidone treatment and with interleukin-6. Iron 0-4 interleukin 6 Homo sapiens 92-105 23529237-6 2013 High glucose promoted NF-kappaB nuclear translocation and significantly enhanced the expression and secretion of both MCP-1 and IL-6 (P<0.01). Glucose 5-12 interleukin 6 Homo sapiens 128-132 23052480-0 2013 Platinum-resistance in ovarian cancer cells is mediated by IL-6 secretion via the increased expression of its target cIAP-2. Platinum 0-8 interleukin 6 Homo sapiens 59-63 23052480-7 2013 Our results revealed a highly significant increase in IL-6 and cIAP-2 mRNA and protein levels upon treatment with cisplatin. Cisplatin 114-123 interleukin 6 Homo sapiens 54-58 23052480-8 2013 WB analysis of cisplatin-treated cells exhibited decreased cIAP-2 expression level following anti-IL-6 Ab addition. Cisplatin 15-24 interleukin 6 Homo sapiens 98-102 23052480-10 2013 Finally, cytotoxicity assays showed sensitization to cisplatin following the addition of IL-6 and cIAP-2 inhibitors. Cisplatin 53-62 interleukin 6 Homo sapiens 89-93 23052480-11 2013 In conclusion, cisplatin treatment of ovarian carcinoma cells upregulates IL-6 and cIAP-2 levels while their inhibition significantly sensitizes them to cisplatin. Cisplatin 15-24 interleukin 6 Homo sapiens 74-78 23052480-12 2013 Here, we present cIAP-2 as a novel inducer of platinum resistance in ovarian carcinoma cells, and suggest an axis beginning with an encounter between cisplatin and these cells, mediated sequentially by IL-6 and cIAP-2, resulting in cisplatin resistance. Cisplatin 150-159 interleukin 6 Homo sapiens 202-206 23052480-12 2013 Here, we present cIAP-2 as a novel inducer of platinum resistance in ovarian carcinoma cells, and suggest an axis beginning with an encounter between cisplatin and these cells, mediated sequentially by IL-6 and cIAP-2, resulting in cisplatin resistance. Cisplatin 232-241 interleukin 6 Homo sapiens 202-206 23529237-7 2013 Pretreatment with high glucose significantly promoted LPS-induced NF-kappaB nuclear translocation (P<0.01) and the mRNA expression and secretion of MCP-1 and IL-6. Glucose 23-30 interleukin 6 Homo sapiens 161-165 23507225-10 2013 A positive correlation existed between IL-1beta and urinary 8-epi-PGF2alpha (r = 0.435, P < .001) and between changes in IL-6 and urinary 8-epi-PGF2alpha (r = 0.393, P < .001). 8-epi-prostaglandin F2alpha 141-156 interleukin 6 Homo sapiens 124-128 22531887-9 2013 IL-6 was significantly positively correlated with HAQ1, PTGA, grade of pain, ESR, platelet count, blood urea, AST level, and anti-CCP level; IL-6 showed an inverse significant correlation with T-score. Urea 104-108 interleukin 6 Homo sapiens 0-4 23398903-14 2013 Combination of Aspirin and Docosahexaenoic Acid showed augmentation in total Glutathione production during TLR-7 stimulation as well as a reduction in IL-6, TNF-alpha and Nitric Oxide. Aspirin 15-22 interleukin 6 Homo sapiens 151-155 22640991-7 2013 The risk of higher levels of TNF-alpha, IL-6, IL-10 and IL-12 was reduced significantly among women with higher Zn concentrations (OR 0 63, 95% CI 0 42, 0 96, P= 0 03; OR 0 57, 95% CI 0 39, 0 86, P= 0 025; OR 0 63, 95% CI 0 41, 0 96, P= 0 04; OR 0 62, 95% CI 0 41, 0 95, P= 0 03, respectively). Zinc 112-114 interleukin 6 Homo sapiens 40-44 23439564-3 2013 PHF, DP and GA could significantly suppress the expression of allergic inflammatory cytokine IL-33-upregulated intercellular adhesion molecule (ICAM)-1, and the release of chemokines CCL2, CCL5, CXCL8 and inflammatory cytokine IL-6 from KU812 cells (all p < 0.05). phf 0-3 interleukin 6 Homo sapiens 227-231 23439564-4 2013 With the combined use of dexamethasone (0.01 mug/mL) and GA (10 mug/mL), the suppression of ICAM-1 expression and CCL5 and IL-6 release of IL-33-activated KU812 cells were significantly greater than the use of GA alone (all p < 0.05). Dexamethasone 25-38 interleukin 6 Homo sapiens 123-127 22531887-13 2013 Patients with RA on steroid therapy had significantly higher TJC, SJC, and DAS-28 score, anti-CCP, and IL-6 than patients with RA not on steroid therapy. Steroids 20-27 interleukin 6 Homo sapiens 103-107 23384353-5 2013 The levels of interleukin (IL)-1beta, lipopolysaccharide-induced tumor necrosis factor-alpha and IL-6 in serum were significantly decreased by GABA at 80 mg/kg (P < 0.05). gamma-Aminobutyric Acid 143-147 interleukin 6 Homo sapiens 97-101 23246534-3 2013 METHODS: Changes in lipopolysaccharide (LPS)-induced interleukin (IL)-6 production and inhibition of IL-6 production by dexamethasone in reaction to the Trier Social Stress Test (TSST) were assessed in forty-six healthy school teachers to test whether chronic work stress is accompanied by alterations in inflammatory activity and glucocorticoid sensitivity of the innate immune system. Dexamethasone 120-133 interleukin 6 Homo sapiens 101-105 23218986-3 2013 Resveratrol, incubated with non-stimulated mononuclear cells, caused a certain reduction of IL-6, IL-1ra and IL-10, and a moderate increase of TNFalpha release. Resveratrol 0-11 interleukin 6 Homo sapiens 92-96 23246534-4 2013 RESULTS: High ERI was associated with an increase in pro-inflammatory potential, reflected in elevated IL-6 production before and after stress and with a lower capacity of dexamethasone to suppress IL-6 production in vitro over all measurement time points. Dexamethasone 172-185 interleukin 6 Homo sapiens 198-202 22160241-8 2013 Significant associations for IL-1beta, IL-6 and adiponectin were observed with the PC1 score, BMI and triacylglycerol; these associations were higher with the PC1 score than with BMI and triacylglycerol. Triglycerides 102-117 interleukin 6 Homo sapiens 39-43 23362950-4 2013 IL-6 and COX-2 were decreased by the free bile acids and increased by the conjugated bile acids. Bile Acids and Salts 42-52 interleukin 6 Homo sapiens 0-4 23362950-4 2013 IL-6 and COX-2 were decreased by the free bile acids and increased by the conjugated bile acids. Bile Acids and Salts 85-95 interleukin 6 Homo sapiens 0-4 23086036-2 2013 We determined the effect of IL-6 exposure on glucose and lipid metabolism in cultured myotubes established from people with normal glucose tolerance or type 2 diabetes. Glucose 45-52 interleukin 6 Homo sapiens 28-32 23086036-3 2013 Acute IL-6 exposure increased glycogen synthesis, glucose uptake, and signal transducer and activator of transcription 3 (STAT3) phosphorylation in cultured myotubes from normal glucose tolerant subjects. Glucose 50-57 interleukin 6 Homo sapiens 6-10 23086036-3 2013 Acute IL-6 exposure increased glycogen synthesis, glucose uptake, and signal transducer and activator of transcription 3 (STAT3) phosphorylation in cultured myotubes from normal glucose tolerant subjects. Glucose 178-185 interleukin 6 Homo sapiens 6-10 23086036-5 2013 IL-6 increased fatty acid oxidation in myotubes from type 2 diabetic and normal glucose tolerant subjects. Fatty Acids 15-25 interleukin 6 Homo sapiens 0-4 23086036-5 2013 IL-6 increased fatty acid oxidation in myotubes from type 2 diabetic and normal glucose tolerant subjects. Glucose 80-87 interleukin 6 Homo sapiens 0-4 23086036-8 2013 In summary, skeletal muscle cells from type 2 diabetic patients display selective IL-6 resistance for glucose rather than lipid metabolism. Glucose 102-109 interleukin 6 Homo sapiens 82-86 23086036-9 2013 In conclusion, IL-6 appears to play a differential role in regulating metabolism in type 2 diabetic patients compared with normal glucose tolerant subjects. Glucose 130-137 interleukin 6 Homo sapiens 15-19 22409372-7 2013 RESULTS: IL-6, TNF-alpha and hs-CRP were significantly and positively correlated with fasting plasma glucose (FPG), insulin and HOMA-IR. Glucose 101-108 interleukin 6 Homo sapiens 9-13 22642912-7 2013 The mRNA expression of osteocalcin and interleukin-6 was significantly lower in MSCs treated with estradiol than those without estradiol. Estradiol 98-107 interleukin 6 Homo sapiens 39-52 22642912-7 2013 The mRNA expression of osteocalcin and interleukin-6 was significantly lower in MSCs treated with estradiol than those without estradiol. Estradiol 127-136 interleukin 6 Homo sapiens 39-52 23063726-6 2013 In the presence of BMSCs, Dex plus BTZ combination inhibited ionizing radiation-induced interleukin 6 secretion from BMSCs and induced myeloma cytotoxicity. Dexamethasone 26-29 interleukin 6 Homo sapiens 88-101 22160241-8 2013 Significant associations for IL-1beta, IL-6 and adiponectin were observed with the PC1 score, BMI and triacylglycerol; these associations were higher with the PC1 score than with BMI and triacylglycerol. Triglycerides 187-202 interleukin 6 Homo sapiens 39-43 23052185-9 2013 Impregnation of lipopolysaccharide-stimulated macrophages with the glucocorticoid dexamethasone further enhanced Zip14 expression while reducing interleukin-6 and tumor necrosis factor-alpha production. Dexamethasone 82-95 interleukin 6 Homo sapiens 145-190 23166300-1 2013 Tyrosine phosphorylation-dependent signaling, as mediated by members of the epidermal growth factor receptor (EGFR) family (ErbB1 to -4) of protein tyrosine kinases (PTKs), Src family PTKs (SFKs), and cytokines such as interleukin-6 (IL-6) that signal via signal transducer and activator of transcription 3 (STAT3), is critical to the development and progression of many human breast cancers. Tyrosine 0-8 interleukin 6 Homo sapiens 219-232 23347846-8 2013 RESULTS: Curcumin effectively blocked IL-1beta and PMA-induced IL-6 expression both in MH7A cells and RA-FLS. Curcumin 9-17 interleukin 6 Homo sapiens 63-67 23160983-9 2013 Dexamethasone"s trans-activation of GILZ and trans-repression of NF-kB-driven IL-6 expression were both inhibited by IL2 + 4; IL17 + IL23 antagonized Dex trans-repression in PBMC from asthmatics. Dexamethasone 0-13 interleukin 6 Homo sapiens 78-82 23139166-3 2013 Treatment with AH inhibited lipopolysaccharide (LPS)-induced interleukin-6, IL-1beta, inducible nitric oxide synthase, and cyclooxygenase-2 expression and nitric oxide production. ah 15-17 interleukin 6 Homo sapiens 61-74 23166300-1 2013 Tyrosine phosphorylation-dependent signaling, as mediated by members of the epidermal growth factor receptor (EGFR) family (ErbB1 to -4) of protein tyrosine kinases (PTKs), Src family PTKs (SFKs), and cytokines such as interleukin-6 (IL-6) that signal via signal transducer and activator of transcription 3 (STAT3), is critical to the development and progression of many human breast cancers. Tyrosine 0-8 interleukin 6 Homo sapiens 234-238 23032719-4 2013 We found that evodiamine suppressed both constitutive and interleukin-6 (IL-6)-induced activation of STAT3 tyrosine 705 (Tyr(705)) effectively. Tyrosine 107-115 interleukin 6 Homo sapiens 58-71 24524011-5 2013 Significant correlations were found at 14-20 weeks gestation between IL-6 & 10, and depression, anxiety, and perceived stress. Adenosine Monophosphate 75-78 interleukin 6 Homo sapiens 69-73 23032719-4 2013 We found that evodiamine suppressed both constitutive and interleukin-6 (IL-6)-induced activation of STAT3 tyrosine 705 (Tyr(705)) effectively. Tyrosine 107-115 interleukin 6 Homo sapiens 73-77 23032719-4 2013 We found that evodiamine suppressed both constitutive and interleukin-6 (IL-6)-induced activation of STAT3 tyrosine 705 (Tyr(705)) effectively. Tyrosine 121-124 interleukin 6 Homo sapiens 58-71 23032719-4 2013 We found that evodiamine suppressed both constitutive and interleukin-6 (IL-6)-induced activation of STAT3 tyrosine 705 (Tyr(705)) effectively. Tyrosine 121-124 interleukin 6 Homo sapiens 73-77 23032719-6 2013 Interestingly, treatment of cells with sodium pervanadate abrogated the inhibition of evodiamine on IL-6-induced STAT3 (Tyr(705)) activation indicating the involvement of protein tyrosine phosphatases. Tyrosine 120-123 interleukin 6 Homo sapiens 100-104 23032719-8 2013 Moreover, inhibition of SHP-1 gene by small interference RNA abolished the ability of evodiamine to inhibit IL-6-induced STAT3 (Tyr(705)) activation. Tyrosine 128-131 interleukin 6 Homo sapiens 108-112 23247593-6 2013 RESULTS: Treatment of U266 cells with berberine (40-160 mumol/L) suppressed cell proliferation and IL-6 secretion in dose- and time-dependent manners. Berberine 38-47 interleukin 6 Homo sapiens 99-103 23139215-6 2013 In the immature xenograft, PCM exposure significantly attenuated LPS and IL-1beta-induced IL-8 and IL-6 expression, decreased TLR2 mRNA and TLR4 mRNA, and increased mRNA levels of specific negative regulators of inflammation, SIGIRR and Tollip. pcm 27-30 interleukin 6 Homo sapiens 99-103 22922248-0 2013 Simvastatin prevents the induction of interleukin-6 gene expression by titanium particles in human osteoblastic cells. Titanium 71-79 interleukin 6 Homo sapiens 38-51 22922248-3 2013 Metal particles specifically up-regulate IL-6 production in bone-forming cells and implant-bone interfacial tissues. Metals 0-5 interleukin 6 Homo sapiens 41-45 22922248-7 2013 The effect of Simv on Ti-induced IL-6 production in osteoblastic cells could not be explained by inhibition of the internalization of metal particles. Titanium 22-24 interleukin 6 Homo sapiens 33-37 23247593-8 2013 Overexpression of miR-21 counteracted berberine-induced suppression of cell proliferation and IL-6 secretion. Berberine 38-47 interleukin 6 Homo sapiens 94-98 24348681-8 2013 Isolated challenge of the keratinocytes with IL-1 beta as well as with glycine resulted in an upregulation of IL6 and IL8 mRNA expression and activation of NF kappa B pathway. Glycine 71-78 interleukin 6 Homo sapiens 110-113 23484124-6 2013 By comparison, exposure to dexamethasone reduced TNF- alpha , IL-6, and IL-1 beta production, while at this time point it increased resistin protein secretion. Dexamethasone 27-40 interleukin 6 Homo sapiens 62-66 23336518-3 2013 The results showed that chlorogenic acid, 3, 4-dicaffeoylquinic acid, 3, 5-dicaffeoylquinic acid and 4, 5-dicaffeoylquinic acid significantly inhibited the prostaglandin E(2) (PGE(2)) release and reversed the interleukin-6 (IL-6) secretion of macrophages (p < 0.05). Chlorogenic Acid 24-40 interleukin 6 Homo sapiens 209-222 23336518-3 2013 The results showed that chlorogenic acid, 3, 4-dicaffeoylquinic acid, 3, 5-dicaffeoylquinic acid and 4, 5-dicaffeoylquinic acid significantly inhibited the prostaglandin E(2) (PGE(2)) release and reversed the interleukin-6 (IL-6) secretion of macrophages (p < 0.05). Chlorogenic Acid 24-40 interleukin 6 Homo sapiens 224-228 23336518-3 2013 The results showed that chlorogenic acid, 3, 4-dicaffeoylquinic acid, 3, 5-dicaffeoylquinic acid and 4, 5-dicaffeoylquinic acid significantly inhibited the prostaglandin E(2) (PGE(2)) release and reversed the interleukin-6 (IL-6) secretion of macrophages (p < 0.05). 3,5-dicaffeoylquinic acid 70-96 interleukin 6 Homo sapiens 209-222 23336518-3 2013 The results showed that chlorogenic acid, 3, 4-dicaffeoylquinic acid, 3, 5-dicaffeoylquinic acid and 4, 5-dicaffeoylquinic acid significantly inhibited the prostaglandin E(2) (PGE(2)) release and reversed the interleukin-6 (IL-6) secretion of macrophages (p < 0.05). 3,5-dicaffeoylquinic acid 70-96 interleukin 6 Homo sapiens 224-228 23336518-3 2013 The results showed that chlorogenic acid, 3, 4-dicaffeoylquinic acid, 3, 5-dicaffeoylquinic acid and 4, 5-dicaffeoylquinic acid significantly inhibited the prostaglandin E(2) (PGE(2)) release and reversed the interleukin-6 (IL-6) secretion of macrophages (p < 0.05). Dinoprostone 156-174 interleukin 6 Homo sapiens 209-222 23336518-3 2013 The results showed that chlorogenic acid, 3, 4-dicaffeoylquinic acid, 3, 5-dicaffeoylquinic acid and 4, 5-dicaffeoylquinic acid significantly inhibited the prostaglandin E(2) (PGE(2)) release and reversed the interleukin-6 (IL-6) secretion of macrophages (p < 0.05). Dinoprostone 156-174 interleukin 6 Homo sapiens 224-228 24469880-8 2013 CONCLUSIONS: Increasing the dose of ASA from 75 mg to 150 mg daily or switching ASA 75 mg to clopidogrel 75 mg daily may reduce concentrations of some inflammatory markers (in particular hsCRP, IL-6 and CD40L) in T2DM patients with HPR treated previously with 75 mg of ASA. Aspirin 36-39 interleukin 6 Homo sapiens 194-198 24469880-8 2013 CONCLUSIONS: Increasing the dose of ASA from 75 mg to 150 mg daily or switching ASA 75 mg to clopidogrel 75 mg daily may reduce concentrations of some inflammatory markers (in particular hsCRP, IL-6 and CD40L) in T2DM patients with HPR treated previously with 75 mg of ASA. Aspirin 80-83 interleukin 6 Homo sapiens 194-198 24469880-8 2013 CONCLUSIONS: Increasing the dose of ASA from 75 mg to 150 mg daily or switching ASA 75 mg to clopidogrel 75 mg daily may reduce concentrations of some inflammatory markers (in particular hsCRP, IL-6 and CD40L) in T2DM patients with HPR treated previously with 75 mg of ASA. Aspirin 80-83 interleukin 6 Homo sapiens 194-198 23420163-10 2013 CONCLUSION: The multiple regression model demonstrated that in addition to age and glycemia (two well-known factors that are directly involved in glucose metabolism), adrenomedullin and IL-6 levels were independent factors associated with lower insulin concentrations. Glucose 146-153 interleukin 6 Homo sapiens 186-190 23879590-3 2013 The inflammatory cytokine IL-6 is frequently up-regulated in Hodgkin"s lymphoma, and IL-6 levels are strongly associated with hepcidin, the main regulator of iron metabolism. Iron 158-162 interleukin 6 Homo sapiens 85-89 23348535-11 2013 IL-6 level correlated negatively with peak oxygen consumption (r = -0.25, p = 0.035) and the IPAQ-SF score (r = -0.26, p = 0.02), and sCD40L level correlated negatively with the IPAQ-SF score (r = -0.4, p = 0.004). Oxygen 43-49 interleukin 6 Homo sapiens 0-4 23037942-4 2013 Both secretion and mRNA expression of IL-6 were significantly up-regulated by EPS in a frequency-dependent manner in contracting myotubes during a 24-h period, and the response was blunted by cyclosporine A, a calcineurin inhibitor. Cyclosporine 192-206 interleukin 6 Homo sapiens 38-42 23037942-7 2013 Importantly, contraction-dependent IL-6 up-regulation was markedly suppressed in the presence of high levels of glucose along with increased glycogen accumulations. Glucose 112-119 interleukin 6 Homo sapiens 35-39 23037942-8 2013 Experimental manipulation of intracellular glycogen contents by modulating available glucose or pyruvate during a certain EPS period further established the suppressive effect of glycogen accumulations on contraction-induced IL-6 up-regulation, which appeared to be independent of calcineurin activity. Glucose 85-92 interleukin 6 Homo sapiens 225-229 23533494-8 2013 Resveratrol significantly decreased CSC-related Shh expression, Gli-1 nuclear translocation, and cell viability in IL-6-treated HL-60 cells and had synergistic effect with Shh inhibitor cyclopamine on inhibiting cell growth. Resveratrol 0-11 interleukin 6 Homo sapiens 115-119 23533494-10 2013 IL-6 stimulated the growth of AML cells through Shh signaling, and this effect might be blocked by resveratrol. Resveratrol 99-110 interleukin 6 Homo sapiens 0-4 23186989-7 2013 In the PBMCs/macrophages of both groups, soluble Abeta (sAbeta) increased the transcription/secretion of cytokines (e.g., IL1 and IL6) and chemokines (e.g., CCLs and CXCLs) and 1,25D3/RvD1 reversed most of the sAbeta effects. sabeta 56-62 interleukin 6 Homo sapiens 130-133 23095208-10 2013 In logistic regression analysis, IL-6, neopterin and Lp-PLA2 levels were detected to be related to high blood glucose levels at 30 min (OR 1.11, p=0.01; OR 9.03, p=0.013; OR 1.01, p=0.004 respectively). Glucose 110-117 interleukin 6 Homo sapiens 33-37 22829554-5 2013 Meta-analysis showed that: 1) steroid group had lower serum IL-6 level on POD 1 and POD 3 (p<0.05), and 2) steroid group had lower serum CRP level on POD 3 (p<0.05) with no significant difference on POD 1 and POD 7. Steroids 30-37 interleukin 6 Homo sapiens 60-64 22829554-6 2013 After stratifying by Pringle maneuver and steroid dosage, we found that: 1) intermittent Pringle maneuver might have a better effect in suppressing releasing IL-6; 2) both 30 mg/kg and a single dose of 500 mg benefited patients in suppressing releasing IL-6. Steroids 42-49 interleukin 6 Homo sapiens 158-162 22841520-5 2013 RESULTS: Compared to placebo, metformin reduced monocyte release of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, monocyte chemoattractant protein-1 and interleukin-8, as well as decreased plasma C-reactive protein levels, which were accompanied by an improvement in insulin sensitivity. Metformin 30-39 interleukin 6 Homo sapiens 116-129 25702427-3 2013 RESULTS: Disorders of carbohydrate metabolism in MS patients are associated with the high levels of systemic inflammation markers (CRP, TNF-alpha, IL-6) and a two-fold rise in the PAI-1 level. Carbohydrates 22-34 interleukin 6 Homo sapiens 147-151 23445730-5 2013 We previously reported that dopamine plays an important role in IL-6-IL-17 axis and subsequent joint destruction in RA. Dopamine 28-36 interleukin 6 Homo sapiens 64-68 23445730-7 2013 Dopamine released by DCs bounded to D1-like dopamine receptors on T cells and induced activation of cAMP and differentiation to Th17 cells via IL-6 production We here overview the interplay among the immune system, bone metabolism and neurologic system shedding light upon dopaminergic signals upon osteoclastogenesis. Dopamine 0-8 interleukin 6 Homo sapiens 143-147 24030317-0 2013 Niflumic acid reduces histamine-induced interleukin-6 and -8 expression in human conjunctival epithelial cells. Histamine 22-31 interleukin 6 Homo sapiens 40-60 24030317-1 2013 BACKGROUND/AIMS: Histamine remains the main mediator of allergic conjunctivitis and induces interleukin (IL)-6 and IL-8 production in human conjunctival epithelial cells (HCEC). Histamine 17-26 interleukin 6 Homo sapiens 92-110 24030317-5 2013 RESULTS: Histamine upregulated IL-6 and IL-8 expression and IL-6 and IL-8 secretion in a dose-dependent manner in HCEC. Histamine 9-18 interleukin 6 Homo sapiens 31-35 24030317-2 2013 The purpose of the present study was to determine whether histamine induced IL-6 and IL-8 expression in HCEC, and to describe the relationship between human calcium-activated chloride channel (hCLCA) 1 activity and IL-6 and IL-8 expression. Histamine 58-67 interleukin 6 Homo sapiens 76-80 24030317-5 2013 RESULTS: Histamine upregulated IL-6 and IL-8 expression and IL-6 and IL-8 secretion in a dose-dependent manner in HCEC. Histamine 9-18 interleukin 6 Homo sapiens 60-64 24553013-0 2013 Increased IL-6 trans-signaling in depression: focus on the tryptophan catabolite pathway, melatonin and neuroprogression. Melatonin 90-99 interleukin 6 Homo sapiens 10-14 24030317-6 2013 Niflumic acid (NFA), an hCLCA blocker, reduced histamine-induced IL-6 and IL-8 expression. Histamine 47-56 interleukin 6 Homo sapiens 65-69 24030317-7 2013 CONCLUSION: Histamine-induced IL-6 and IL-8 production could be attenuated by NFA, an hCLCA blocker. Histamine 12-21 interleukin 6 Homo sapiens 30-34 23844276-6 2013 Arachidonic acid and saturated fatty acids (SFAs) both demonstrate an ability to increase pro-inflammatory IL-8 along with numerous other inflammatory factors including IL-6, TNF alpha , IL-1 beta , and CXCL1 for arachidonic acid and IGB2 and CTSS for SFA. Arachidonic Acid 0-16 interleukin 6 Homo sapiens 169-173 23844276-6 2013 Arachidonic acid and saturated fatty acids (SFAs) both demonstrate an ability to increase pro-inflammatory IL-8 along with numerous other inflammatory factors including IL-6, TNF alpha , IL-1 beta , and CXCL1 for arachidonic acid and IGB2 and CTSS for SFA. Fatty Acids 21-42 interleukin 6 Homo sapiens 169-173 24399727-6 2013 RESULTS: Metformin treatment reduced plasma C-reactive protein levels and monocyte release of tumor necrosis factor-alpha and interleukin-6, as well as tended to reduce monocyte release of interleukin-1beta and monocyte chemoattractant protein-1, which was accompanied by an improvement in insulin sensitivity. Metformin 9-18 interleukin 6 Homo sapiens 126-139 24553013-9 2013 Second, the more systemic regulation of tryptophan availability occurs via the IL-6 induction of IDO. Tryptophan 40-50 interleukin 6 Homo sapiens 79-83 23372793-11 2013 These findings might be beneficial for the development of the large-scale production of IL6 under the conditions of current good manufacturing practice (cGMP). Cyclic GMP 153-157 interleukin 6 Homo sapiens 88-91 23555637-4 2013 METHODS AND RESULTS: Confluent human umbilical vein endothelial cell (HUVECs ) treated with atorvastatin demonstrated significantly decreased lipopolysaccharide (LPS)-mediated IL-6 and IL-8 generation. Atorvastatin 92-104 interleukin 6 Homo sapiens 176-180 23520526-5 2013 Hypoxia also antagonized thapsigargin-induced IL-6 gene expression. Thapsigargin 25-37 interleukin 6 Homo sapiens 46-50 23533638-6 2013 As IL-6 expression (like MKP-1) is cAMP/adenylate cyclase-mediated, the long-acting beta2-agonist formoterol increased IL-6 mRNA expression and secretion. Cyclic AMP 35-39 interleukin 6 Homo sapiens 3-7 23469045-5 2013 Rivastigmine (1 mg/kg) also reduced myeloperoxidase activity and IL-6 by >60%, and the infiltration of CD11b expressing cells by 80%. Rivastigmine 0-12 interleukin 6 Homo sapiens 65-69 23372745-9 2013 Serum 25(OH)D concentration correlated negatively with both IL-6 (P = 0.02) and hsCRP serum concentration (P = 0.03) at baseline. 25(oh)d 6-13 interleukin 6 Homo sapiens 60-64 23430960-10 2013 Moreover, the use of this cephalosporin is associated with a significant reduction of interleukin-6 and KL-6, two key mediators of lung inflammation and epithelial damage. Cephalosporins 26-39 interleukin 6 Homo sapiens 86-99 23308138-7 2013 Analyzing the impact of sirolimus introduction on cytokine microenvironment, we observed an increase of IL6 and TNFalpha without compensation of the negative feedback loops dependent on IL10 and soluble TNF receptors. Sirolimus 24-33 interleukin 6 Homo sapiens 104-107 22985912-6 2013 N-acetylcysteine prevented morphologic and oxidative derangements, and significantly reduced proinflammatory product secretion (P range<0.0001 to<0.00001 for TNFalpha, VCAM-1, MCP-1, and IL-6); rosuvastatin inhibited morphology and oxidative modifications only. Acetylcysteine 0-16 interleukin 6 Homo sapiens 193-197 23259689-7 2012 However, all the PUFA tested: DHA, EPA and to a lesser extent OA down-regulated TNF-alpha, IL-6 and MCP-1 secretion in human adipose tissue and adipocytes cultures. dehydroacetic acid 30-33 interleukin 6 Homo sapiens 91-95 23210512-0 2012 Silibinin inhibits the invasion of IL-6-stimulated colon cancer cells via selective JNK/AP-1/MMP-2 modulation in vitro. Silybin 0-9 interleukin 6 Homo sapiens 35-39 23210512-2 2012 This study investigated silibinin inhibition of cell invasion by down-regulating matrix metalloproteinase-2 (MMP-2) expression, via attenuation of activator protein-1 (AP-1) in IL-6-stimulated LoVo colon cancer cells. Silybin 24-33 interleukin 6 Homo sapiens 177-181 23210512-6 2012 Finally, a [(3)H]-thymidine incorporation proliferation assay and cell migration assay demonstrated that silibinin inhibited IL-6-stimulated LoVo cell proliferation and invasion. Silybin 105-114 interleukin 6 Homo sapiens 125-129 23097096-3 2012 We had found a significant decrease in IL-6 in patients having bilateral total knee replacement who received two doses of 100 mg of hydrocortisone eight hours apart; however, by twenty-four hours, IL-6 levels were equal to those in the group that received a placebo. Hydrocortisone 132-146 interleukin 6 Homo sapiens 39-43 24175257-6 2012 Cyclosporine A (CsA) and tacrolimus (Tac) are T-cell-specific calcineurin inhibitors that prevent the activation of helper T cells, thereby inhibiting the transcription of the early activation genes of interleukin (IL)-2 and suppressing T cell-induced activation of tumor necrosis factor-alpha, IL-1beta and IL-6. Cyclosporine 0-14 interleukin 6 Homo sapiens 308-312 24175257-6 2012 Cyclosporine A (CsA) and tacrolimus (Tac) are T-cell-specific calcineurin inhibitors that prevent the activation of helper T cells, thereby inhibiting the transcription of the early activation genes of interleukin (IL)-2 and suppressing T cell-induced activation of tumor necrosis factor-alpha, IL-1beta and IL-6. Cyclosporine 16-19 interleukin 6 Homo sapiens 308-312 22494810-0 2012 Correlation between high blood IL-6 level, hyperglycemia, and glucose control in septic patients. Glucose 62-69 interleukin 6 Homo sapiens 31-35 22494810-1 2012 INTRODUCTION: The aim of the present study was to investigate the relationship between the blood IL-6 level, the blood glucose level, and glucose control in septic patients. Glucose 138-145 interleukin 6 Homo sapiens 97-101 22494810-4 2012 RESULTS: A significant positive correlation between blood IL-6 level and blood glucose level on ICU admission was observed in the overall study population (n = 153; r = 0.24, P = 0.01), and was stronger in the nondiabetic subgroup (n = 112; r = 0.42, P < 0.01). Glucose 79-86 interleukin 6 Homo sapiens 58-62 22494810-5 2012 The rate of successful glucose control (blood glucose level < 150 mg/dl maintained for 6 days or longer) decreased with increase in blood IL-6 level on ICU admission (P < 0.01). Glucose 23-30 interleukin 6 Homo sapiens 141-145 22494810-7 2012 CONCLUSIONS: High blood IL-6 level was correlated with hyperglycemia and with difficulties in glucose control in septic patients. Glucose 94-101 interleukin 6 Homo sapiens 24-28 23097096-14 2012 CONCLUSIONS: Hydrocortisone (100 mg) given over three doses, each eight hours apart, decreased and maintained a lower degree of inflammation with bilateral total knee replacement as measured by IL-6 level. Hydrocortisone 13-27 interleukin 6 Homo sapiens 194-198 23210974-6 2012 Decreased levels of IL-6 and TNF-alpha in response to ATP were shown in both P2X7MUT and P2X7WT subjects, which was less pronounced in P2X7MUT subjects. Adenosine Triphosphate 54-57 interleukin 6 Homo sapiens 20-24 23065424-6 2012 The maximum effect on Fe uptake was observed in cells incubated with 30 ng/ml IL6 (p < 0.01) and 500 ng/ml LPS (p < 0.05). Iron 22-24 interleukin 6 Homo sapiens 78-81 23385065-3 2012 Here we demonstrate that media conditioned by cells undergoing any of the three main forms of senescence, i.e. replicative, oncogene- and drug-induced, contain high levels of IL1, IL6, and TGFb capable of inducing reactive oxygen species (ROS)-mediated DNA damage response (DDR). Reactive Oxygen Species 214-237 interleukin 6 Homo sapiens 180-183 23385065-3 2012 Here we demonstrate that media conditioned by cells undergoing any of the three main forms of senescence, i.e. replicative, oncogene- and drug-induced, contain high levels of IL1, IL6, and TGFb capable of inducing reactive oxygen species (ROS)-mediated DNA damage response (DDR). Reactive Oxygen Species 239-242 interleukin 6 Homo sapiens 180-183 22871993-7 2012 In cultured melanocytes, subtoxic levels of H(2)O(2) (30-300 muM) significantly increased the IL-6 mRNA and protein levels in a dose-dependent manner. Hydrogen 44-48 interleukin 6 Homo sapiens 94-98 22941906-10 2012 CP-690,550 significantly decreased the expression of interleukin-6 in synovial macrophages. tofacitinib 0-6 interleukin 6 Homo sapiens 53-66 22871993-0 2012 Subtoxic levels hydrogen peroxide-induced expression of interleukin-6 by epidermal melanocytes. Hydrogen Peroxide 16-33 interleukin 6 Homo sapiens 56-69 22925537-9 2012 One year intervention with vitamin D decreased serum IL-6 levels; however hs-CRP levels were significantly increased. Vitamin D 27-36 interleukin 6 Homo sapiens 53-57 22752961-8 2012 The testosterone reduction was related to increases in weight and IL-6. Testosterone 4-16 interleukin 6 Homo sapiens 66-70 22939972-1 2012 Previously we reported that the sesquiterpene lactone parthenolide induces oxidative stress in cardiac myocytes, which blocks Janus kinase (JAK) activation by the interleukin 6 (IL-6)-type cytokines. parthenolide 54-66 interleukin 6 Homo sapiens 163-176 22939972-1 2012 Previously we reported that the sesquiterpene lactone parthenolide induces oxidative stress in cardiac myocytes, which blocks Janus kinase (JAK) activation by the interleukin 6 (IL-6)-type cytokines. parthenolide 54-66 interleukin 6 Homo sapiens 178-182 22391518-10 2012 A positive correlation was found between IL-6 and glucose or triglyceride concentrations, while the correlation with HDL cholesterol was negative. Glucose 50-57 interleukin 6 Homo sapiens 41-45 22391518-10 2012 A positive correlation was found between IL-6 and glucose or triglyceride concentrations, while the correlation with HDL cholesterol was negative. Triglycerides 61-73 interleukin 6 Homo sapiens 41-45 23033490-8 2012 In contrast, dexamethasone suppressed cell invasion, the expression of its related genes [MMP-2/MMP-9, interleukin (IL)-6, VEGF], and the activity of MMP-2/MMP-9, and also induced mesenchymal-to-epithelial transition. Dexamethasone 13-26 interleukin 6 Homo sapiens 103-121 23125416-8 2012 Neutralizing Ab to IL-6 inhibited CCL15-mediated STAT3 Tyr(705) phosphorylation, whereas inhibition of STAT3 activity abolished CCL15-activated CXCL8 release. Tyrosine 55-58 interleukin 6 Homo sapiens 19-23 23088987-7 2012 RESULTS: ATP and ATP-gamma-S (Roche Diagnostics, Mannheim, Germany) were equipotent as inducers of interleukin-8 and 6 release. Adenosine Triphosphate 9-12 interleukin 6 Homo sapiens 99-118 23088987-7 2012 RESULTS: ATP and ATP-gamma-S (Roche Diagnostics, Mannheim, Germany) were equipotent as inducers of interleukin-8 and 6 release. adenosine 5'-O-(3-thiotriphosphate) 17-28 interleukin 6 Homo sapiens 99-118 22535284-7 2012 Additionally, a higher oxygen tension led to an upregulation of the expression of IL-6, MCP-1, and PPAR-gamma, while ANGPTL4 was downregulated in the hyperoxia group with respect to control. Oxygen 23-29 interleukin 6 Homo sapiens 82-86 23041664-9 2012 ETR-P1/fl administration after CLP resulted in lower serum TH at 1 and 3 h after CLP, OSI at 1 and 3 h after CLP, IL-6 at 1 and 3 h after CLP, and GOT at 3 and 6 h after CLP as compared with the CLP group. etr-p1 0-6 interleukin 6 Homo sapiens 114-118 22677645-9 2012 For men only there were significant (at least P < 0.05), positive correlations between adipocyte Cer-containing saturated fatty acid and plasma IL-6 concentration. Fatty Acids 115-135 interleukin 6 Homo sapiens 147-151 23041664-10 2012 CONCLUSION: ETR-P1/fl treatment significantly attenuated the elevation of serum oxidative stress markers (TH and OSI), IL-6, and GOT in a progressive neonatal sepsis CLP model. etr-p1 12-18 interleukin 6 Homo sapiens 119-123 21909945-4 2012 In this study, we measured reactive oxygen species using a free radical analytical system in patients with rheumatoid arthritis treated with disease-modifying antirheumatic drugs, tumor necrosis factor-alpha-blocking drugs (infliximab, etanercept), and an interleukin-6-blocking drug (tocilizumab). Reactive Oxygen Species 27-50 interleukin 6 Homo sapiens 256-269 22995520-0 2012 TLR 2 induces vascular smooth muscle cell migration through cAMP response element-binding protein-mediated interleukin-6 production. Cyclic AMP 60-64 interleukin 6 Homo sapiens 107-120 22836384-8 2012 The typical changes of iron metabolism and hepcidin synthesis in RA are induced by proinflammatory cytokines, primarily interleukin-6. Iron 23-27 interleukin 6 Homo sapiens 120-133 22425757-9 2012 Accordingly, (-)-epicatechin inhibited TNFalpha-mediated altered transcription of genes (MCP-1, interleukin-6, TNFalpha, resistin, and protein-tyrosine phosphatase 1B) involved in inflammation and insulin signaling. Catechin 13-28 interleukin 6 Homo sapiens 96-109 23140401-6 2012 We also measured the IL-6 concentration secreted by peripheral blood mononuclear cells (PBMCs) incubated with (a) oligonucleotide (CpG-B) in the presence or absence of recombinant human PGRN (rhPGRN); and (b) lupus sera in the presence or absence of a neutralizing anti-PGRN antibody. Oligonucleotides 114-129 interleukin 6 Homo sapiens 21-25 23285694-0 2012 Effect of Gly-Gly-His, Gly-His-Lys and their copper complexes on TNF-alpha-dependent IL-6 secretion in normal human dermal fibroblasts. Lysine 31-34 interleukin 6 Homo sapiens 85-89 23285694-0 2012 Effect of Gly-Gly-His, Gly-His-Lys and their copper complexes on TNF-alpha-dependent IL-6 secretion in normal human dermal fibroblasts. Copper 45-51 interleukin 6 Homo sapiens 85-89 23285694-7 2012 GHK and their copper complexes and saccharomyces/copper ferment (Oligolides Copper) on secretion of pro-inflammatory IL-6 in normal human dermal fibroblasts NHDF cell line. Copper 14-20 interleukin 6 Homo sapiens 117-121 23285694-7 2012 GHK and their copper complexes and saccharomyces/copper ferment (Oligolides Copper) on secretion of pro-inflammatory IL-6 in normal human dermal fibroblasts NHDF cell line. Copper 49-55 interleukin 6 Homo sapiens 117-121 23285694-7 2012 GHK and their copper complexes and saccharomyces/copper ferment (Oligolides Copper) on secretion of pro-inflammatory IL-6 in normal human dermal fibroblasts NHDF cell line. Copper 76-82 interleukin 6 Homo sapiens 117-121 23285694-9 2012 GGH, GHK, CuCl2 and their copper complexes decreased TNF-alpha-dependent IL-6 secretion in fibroblasts. Copper 26-32 interleukin 6 Homo sapiens 73-77 23041168-8 2012 We found that TCOH, but not TCA, increased the levels of IL-1alpha and IL-6 in a dose-dependent manner. 2,2,2-trichloroethanol 14-18 interleukin 6 Homo sapiens 71-75 23041168-10 2012 Bay 11-7082 (NF-kappaB inhibitor) significantly attenuated the TCOH-induced production of IL-6 in HaCaT cells, but IL-1alpha production was not affected. 2,2,2-trichloroethanol 63-67 interleukin 6 Homo sapiens 90-94 23041168-12 2012 TCOH induced IL-6 expression through activation of the NF-kappaB pathway in HaCaT cells and may play an integral role in TCE-induced skin hypersensitivity. 2,2,2-trichloroethanol 0-4 interleukin 6 Homo sapiens 13-17 23170847-10 2012 The association between PBM culture secretion of H2O2 and the production of TNF-alpha and IL-6 was not significant. Hydrogen Peroxide 49-53 interleukin 6 Homo sapiens 90-94 23131831-8 2012 Replacement of the IKKgamma/NEMO S377 residue by alanine (S377A) or glutamic acid (S377E) resulted in a significant increase or decrease of NF-kappaB activity and TNF-alpha-mediated IL-6 cytokine production, respectively. Alanine 49-56 interleukin 6 Homo sapiens 182-186 23131831-8 2012 Replacement of the IKKgamma/NEMO S377 residue by alanine (S377A) or glutamic acid (S377E) resulted in a significant increase or decrease of NF-kappaB activity and TNF-alpha-mediated IL-6 cytokine production, respectively. Glutamic Acid 68-81 interleukin 6 Homo sapiens 182-186 22995520-8 2012 Blockade of p38 mitogen-associated protein kinase or extracellular signal-regulated kinase 1/2 activation inhibited TLR2 agonist pam3CSK4-induced phosphorylation of cAMP response element-binding protein, which regulates IL-6 promoter activity through the cAMP response element site. Cyclic AMP 165-169 interleukin 6 Homo sapiens 220-224 22995520-8 2012 Blockade of p38 mitogen-associated protein kinase or extracellular signal-regulated kinase 1/2 activation inhibited TLR2 agonist pam3CSK4-induced phosphorylation of cAMP response element-binding protein, which regulates IL-6 promoter activity through the cAMP response element site. Cyclic AMP 255-259 interleukin 6 Homo sapiens 220-224 22995520-9 2012 Moreover, cAMP response element-binding protein small interfering RNA inhibited pam3CSK4-induced IL-6 production and VSMC migration. Cyclic AMP 10-14 interleukin 6 Homo sapiens 97-101 22995520-12 2012 These signaling pathways act in concert to activate cAMP response element-binding protein and subsequent IL-6 production, which in turn promotes VSMC migration via Rac1-mediated actin cytoskeletal reorganization. Cyclic AMP 52-56 interleukin 6 Homo sapiens 105-109 22475642-5 2012 RESULTS: PGE2 significantly attenuated the expression of CC chemokine ligand (CCL)5 (P < 0.0005), CCL20 (P < 0.0005), C-X-C chemokine (CXCL)10 (P < 0.0005), CXCL11 (P < 0.05), and interleukin (IL)-6 (P < 0.005) in human corneal-limbal epithelial cells. Dinoprostone 9-13 interleukin 6 Homo sapiens 192-210 22475642-7 2012 The EP2 agonist significantly suppressed the polyI:C-induced expression of CCL5 (P < 0.005), CXCL10 (P < 0.0005), and CXCL11 (P < 0.05) but not of CCL20 and IL-6. Poly I 45-50 interleukin 6 Homo sapiens 166-170 22475642-7 2012 The EP2 agonist significantly suppressed the polyI:C-induced expression of CCL5 (P < 0.005), CXCL10 (P < 0.0005), and CXCL11 (P < 0.05) but not of CCL20 and IL-6. Carbon 51-52 interleukin 6 Homo sapiens 166-170 22475642-10 2012 CONCLUSIONS: Our results show that in human corneal epithelial cells, PGE2 attenuated the mRNA expression and production of CCL5, CXCL10, and CXCL11 via both EP2 and EP3, and that the mRNA expression and production of CCL20 and IL-6 was attenuated only by EP3. Dinoprostone 70-74 interleukin 6 Homo sapiens 228-232 22940192-6 2012 PAHs in PM, particularly those with 4-6 rings, were associated with NO suppression, and ET-1 and IL-6 were positively correlated with the amount of trace metal compounds. Metals 154-159 interleukin 6 Homo sapiens 97-101 22740511-10 2012 Additionally, IL-6-induced migration was significantly diminished by phosphatidyl inositol 3-phosphate kinase (PI3K) inhibitor (wortamannin) and beta-catenin inhibitor FH535. wortamannin 128-139 interleukin 6 Homo sapiens 14-18 23182014-0 2012 Interleukin-6 responses to water immersion therapy after acute exercise heat stress: a pilot investigation. Water 27-32 interleukin 6 Homo sapiens 0-13 23182014-3 2012 The kinetics of inflammatory markers, such as interleukin-6 (IL-6), during cold-water immersion have not been characterized. Water 80-85 interleukin 6 Homo sapiens 46-59 23182014-3 2012 The kinetics of inflammatory markers, such as interleukin-6 (IL-6), during cold-water immersion have not been characterized. Water 80-85 interleukin 6 Homo sapiens 61-65 23182014-4 2012 OBJECTIVE: To characterize serum IL-6 responses to water immersion at 2 temperatures and, therefore, to initiate further research into the multidimensional benefits of immersion and the evidence-based selection of specific, optimal immersion conditions by athletic trainers. Water 51-56 interleukin 6 Homo sapiens 33-37 23182014-11 2012 CONCLUSIONS: We have provided seed evidence that cold-water immersion is related to subtle IL-6 increases from postexercise values and that warmer water-bath temperatures might dampen this increase. Water 54-59 interleukin 6 Homo sapiens 91-95 22915474-6 2012 Here, we demonstrate that melamine can activate mitogen-activated protein kinases, NFkappaB, and reactive oxygen species, which results in the upregulation of interleukin-6, monocyte chemoattractant protein-1, vascular cell adhesion molecule-1, and TGF-beta1 in HK-2 cells. Reactive Oxygen Species 97-120 interleukin 6 Homo sapiens 159-172 22927445-7 2012 The pan-PKC inhibitor Go6850 and the PKCepsilon inhibitor Ro-31-8220 abrogated the augmenting effect of IL-32alpha on IL-6 production, whereas the classical PKC inhibitor Go6976 and the PKCdelta inhibitor rottlerin did not. Ro 31-8220 58-68 interleukin 6 Homo sapiens 118-122 22713513-8 2012 Pearson correlation analysis revealed that D-lactate was positively correlated to IL-6 and L-lactate (r=0.727, 0.789 and P=0.000, 0.000, respectively). Lactic Acid 43-52 interleukin 6 Homo sapiens 82-86 23351427-3 2012 Our purpose is to study the prophylactic effect of HS 5% infusion versus NS on serum IL-6 as an inflammatory & IL-10 as an anti-inflammatory biomarker in CABG patients. Hydrogen 51-53 interleukin 6 Homo sapiens 85-89 23351427-3 2012 Our purpose is to study the prophylactic effect of HS 5% infusion versus NS on serum IL-6 as an inflammatory & IL-10 as an anti-inflammatory biomarker in CABG patients. Nitrogen 73-75 interleukin 6 Homo sapiens 85-89 23351427-3 2012 Our purpose is to study the prophylactic effect of HS 5% infusion versus NS on serum IL-6 as an inflammatory & IL-10 as an anti-inflammatory biomarker in CABG patients. Adenosine Monophosphate 110-113 interleukin 6 Homo sapiens 85-89 22927445-4 2012 We show that phorbol 12-myristate 13-acetate (PMA)-induced increase in IL-6 production by IL-32alpha-expressing cells was higher than that by empty vector-expressing cells and that this increase occurred in a time- and dose-dependent manner. Tetradecanoylphorbol Acetate 13-44 interleukin 6 Homo sapiens 71-75 22927445-4 2012 We show that phorbol 12-myristate 13-acetate (PMA)-induced increase in IL-6 production by IL-32alpha-expressing cells was higher than that by empty vector-expressing cells and that this increase occurred in a time- and dose-dependent manner. Tetradecanoylphorbol Acetate 46-49 interleukin 6 Homo sapiens 71-75 22426798-7 2012 mRNA relative abundance of nuclear factor kappa-light-chain-enhancer of activated B cells was elevated in OBDM with anemia, and mRNA expression of interleukin-6 and toll-like receptor (TLR) 2 was increased in OBDM group in basal high Fe and high glucose concentrations. Iron 234-236 interleukin 6 Homo sapiens 147-160 22747921-10 2012 CONCLUSIONS: Progesterone enhances immunomodulatory function of MSCs through up-regulation of PGE2 and IL-6. Progesterone 13-25 interleukin 6 Homo sapiens 103-107 23108749-3 2012 RESULTS: Significant increases were detected in the median values of ROS and IL-6 in patients with T1DM compared with healthy subjects (ROS ~ 4,836 vs. 2,036 RLU/min, respectively; P < .05: IL-6 ~ 14.2 vs. 9.7 pg/mL, respectively; P = .002). Reactive Oxygen Species 136-139 interleukin 6 Homo sapiens 77-81 22426798-7 2012 mRNA relative abundance of nuclear factor kappa-light-chain-enhancer of activated B cells was elevated in OBDM with anemia, and mRNA expression of interleukin-6 and toll-like receptor (TLR) 2 was increased in OBDM group in basal high Fe and high glucose concentrations. Glucose 246-253 interleukin 6 Homo sapiens 147-160 22709338-4 2012 RESULTS: The data confirmed the important effect of radiation on the IL-6 pathway, clearly showing a crucial role of the ROS (Reactive Oxygen Species) in transducing the effect of initial radiation exposure and the subsequent long-term release of IL-6. Reactive Oxygen Species 121-124 interleukin 6 Homo sapiens 69-73 22923236-6 2012 Neutralizing antibodies against IL-6 and IL-8 partially reversed the drug resistance of MCF-7/R to paclitaxel and doxorubicin, while a neutralizing antibody against MCP-1 had no significant effect. Paclitaxel 99-109 interleukin 6 Homo sapiens 32-36 22923236-6 2012 Neutralizing antibodies against IL-6 and IL-8 partially reversed the drug resistance of MCF-7/R to paclitaxel and doxorubicin, while a neutralizing antibody against MCP-1 had no significant effect. Doxorubicin 114-125 interleukin 6 Homo sapiens 32-36 22715179-11 2012 Severe vitamin D deficiency (total 25(OH)D <25 nmol/L) was associated with higher baseline TNF, IL-6, and IL-8 irrespective of IRIS status. Vitamin D 7-16 interleukin 6 Homo sapiens 99-103 23170143-3 2012 Recent studies have shown that cerulein-activated nicotinamide adenine dinucleotide phosphate oxidase elicits reactive oxygen species, which trigger the phosphorylation of the JAK1, STAT1, and STAT3 proteins and induce the production of inflammatory cytokines, such as tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-6, in pancreatic acinar cells. Reactive Oxygen Species 110-133 interleukin 6 Homo sapiens 326-330 22696070-0 2012 Enhancement of protease-induced IL-6 release in monocytic U-937 cells by phorbol-12-myristate-13-acetate. Tetradecanoylphorbol Acetate 73-104 interleukin 6 Homo sapiens 32-36 22696070-1 2012 OBJECTIVE AND DESIGN: Serine proteases and phorbol-12-myristate-13-acetate (PMA) are able to induce the release of pro-inflammatory interleukin-6 (IL-6) in monocytic cells. Tetradecanoylphorbol Acetate 43-74 interleukin 6 Homo sapiens 147-151 22696070-1 2012 OBJECTIVE AND DESIGN: Serine proteases and phorbol-12-myristate-13-acetate (PMA) are able to induce the release of pro-inflammatory interleukin-6 (IL-6) in monocytic cells. Tetradecanoylphorbol Acetate 76-79 interleukin 6 Homo sapiens 147-151 22280420-9 2012 Role of cytokines such as TNF-alpha, IL-17 or IL-6 and their links to superoxide and hydrogen peroxide production are discussed. Superoxides 70-80 interleukin 6 Homo sapiens 46-50 22280420-9 2012 Role of cytokines such as TNF-alpha, IL-17 or IL-6 and their links to superoxide and hydrogen peroxide production are discussed. Hydrogen Peroxide 85-102 interleukin 6 Homo sapiens 46-50 22267768-7 2012 In the AZD9668 group, there was a trend towards reduction in sputum inflammatory biomarkers with statistically significant changes in interleukin-6, RANTES and urinary desmosine. N-((5-(methanesulfonyl)pyridin-2-yl)methyl)-6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide 7-14 interleukin 6 Homo sapiens 134-147 22709338-4 2012 RESULTS: The data confirmed the important effect of radiation on the IL-6 pathway, clearly showing a crucial role of the ROS (Reactive Oxygen Species) in transducing the effect of initial radiation exposure and the subsequent long-term release of IL-6. Reactive Oxygen Species 121-124 interleukin 6 Homo sapiens 247-251 22709338-4 2012 RESULTS: The data confirmed the important effect of radiation on the IL-6 pathway, clearly showing a crucial role of the ROS (Reactive Oxygen Species) in transducing the effect of initial radiation exposure and the subsequent long-term release of IL-6. Reactive Oxygen Species 126-149 interleukin 6 Homo sapiens 69-73 22709338-4 2012 RESULTS: The data confirmed the important effect of radiation on the IL-6 pathway, clearly showing a crucial role of the ROS (Reactive Oxygen Species) in transducing the effect of initial radiation exposure and the subsequent long-term release of IL-6. Reactive Oxygen Species 126-149 interleukin 6 Homo sapiens 247-251 22791764-13 2012 Up-regulation of RANKL and OPG mRNA by IL-6 was suppressed by dexamethasone. Dexamethasone 62-75 interleukin 6 Homo sapiens 39-43 22381051-9 2012 The level of IL-6 at the end of surgery was lower for sevoflurane (69.5 [35.9-121.0] pg/mL) than propofol-remifentanil (128.2 [92.8-163.8] pg/mL, p = 0.03), but this difference was not maintained 24 hours after surgery. Sevoflurane 54-65 interleukin 6 Homo sapiens 13-17 22381051-12 2012 CONCLUSIONS: Sevoflurane anesthesia attenuated an increase in blood IL-6 at the end of surgery but did not provide any advantages over propofol remifentanil in terms of postoperative pulmonary complications in Ivor Lewis operations. Sevoflurane 13-24 interleukin 6 Homo sapiens 68-72 22787116-10 2012 MG262 concentration-dependently inhibited basal and transforming growth factor-beta-induced collagen mRNA expression and interleukin (IL)-1beta-induced production of IL-6, IL-8, monocyte chemoattractant protein-1, regulated on activation normal T cell expressed and secreted, and granulocyte/macrophage colony-stimulating factor in both fibroblast types. MG 262 0-5 interleukin 6 Homo sapiens 166-170 22320379-5 2012 RESULTS: The findings show that interleukin concentrations (IL-6, IL-8, TNF-alpha) were significantly decreased between 0 and 72 hours (p < 0.01) in the newborns exposed to initial oxygen concentration of 45% and significantly increased in the other group. Oxygen 184-190 interleukin 6 Homo sapiens 60-64 22722257-5 2012 In patients with PDAC, circulating IL-6, TNF-alpha, IL-1beta, and IL-10 correlated with serum concentrations of vascular endothelial growth factor and basic fibroblast growth factor; circulating IL-6, IL-1beta, and TNF-alpha correlated with carbohydrate 19-9; and IL-8, IL-10, and TNF-alpha correlated with CEA levels. Carbohydrates 241-253 interleukin 6 Homo sapiens 35-39 23103560-3 2012 RESULTS: Atorvastatin incubation resulted in significant decreases in the levels of TLR4 protein and mRNA, NF-kappaB expression, and levels of TNF-alpha, IL-6, and IL-1beta in LPS-induced THP-1 cells (P<0.01). Atorvastatin 9-21 interleukin 6 Homo sapiens 154-158 21979577-8 2012 SB203580 inhibited ATP-induced TNF-alpha, IL-6, and NO production. Adenosine Triphosphate 19-22 interleukin 6 Homo sapiens 42-46 22690903-5 2012 Only lipopolysaccharide (LPS), poly(I:C), Pam3CSK4 and MALP-2 could induce the production of IL-6, IL-8 and MCP-1 by adipocytes. Poly I 31-37 interleukin 6 Homo sapiens 93-97 22690903-5 2012 Only lipopolysaccharide (LPS), poly(I:C), Pam3CSK4 and MALP-2 could induce the production of IL-6, IL-8 and MCP-1 by adipocytes. Carbon 38-39 interleukin 6 Homo sapiens 93-97 22847808-12 2012 Let-7 modulates the chemosensitivity to cisplatin through the regulation of IL-6/STAT3 pathway in esophageal cancer. Cisplatin 40-49 interleukin 6 Homo sapiens 76-80 22843691-6 2012 The induced TRPA1 channels, which were intrinsically activated by endogenous hydrogen peroxide and Zn(2+), suppressed secretion of interleukin-6 and interleukin-8. Hydrogen Peroxide 77-94 interleukin 6 Homo sapiens 131-144 22843691-6 2012 The induced TRPA1 channels, which were intrinsically activated by endogenous hydrogen peroxide and Zn(2+), suppressed secretion of interleukin-6 and interleukin-8. Zinc 99-101 interleukin 6 Homo sapiens 131-144 23351387-2 2012 OBJECTIVE: To evaluate the role of prophylactic ibuprofen and N-acetylcysteine (NAC) on the levels of tumor necrosis factor alpha (TNF- alpha), interleukin- 6(IL-6) and IL-17 and post-treatment pain level in chronic periapical lesions. Acetylcysteine 80-83 interleukin 6 Homo sapiens 144-158 23351387-6 2012 RESULTS: There was a significant difference in IL-6 level between ibuprofen group and placebo (p = 0.019). Ibuprofen 66-75 interleukin 6 Homo sapiens 47-51 22805498-5 2012 In the vitamin D group, there was a 50.4% reduction in tumor necrosis factor-alpha (TNF-alpha) at 12 weeks (P<0.01), and there was a trend for a 64.5% reduction in interleukin-6 (IL-6) (P=0.09). Vitamin D 7-16 interleukin 6 Homo sapiens 167-180 22805498-5 2012 In the vitamin D group, there was a 50.4% reduction in tumor necrosis factor-alpha (TNF-alpha) at 12 weeks (P<0.01), and there was a trend for a 64.5% reduction in interleukin-6 (IL-6) (P=0.09). Vitamin D 7-16 interleukin 6 Homo sapiens 182-186 22805498-7 2012 We conclude that a large bolus dose of vitamin D is associated with reductions in two inflammatory cytokines, IL-6 and TNF-alpha. Vitamin D 39-48 interleukin 6 Homo sapiens 110-114 22812678-7 2012 Concurrent acute ethanol exposure and LPS treatment resulted in a dose-dependent suppression of IL-6, IL-12p40, IL-23, and IL-10. Ethanol 17-24 interleukin 6 Homo sapiens 96-100 22812678-8 2012 In addition, ethanol exposure before LPS dysregulated the IL-12p40/IL-23 balance and more profoundly suppressed IL-6 and IL-10 secretion by BM-DCs, as compared with cells concurrently treated with ethanol and LPS. Ethanol 13-20 interleukin 6 Homo sapiens 112-116 22901451-13 2012 Untreated macrophages show dopamine mediated increases IL-6 and CCL2. Dopamine 27-35 interleukin 6 Homo sapiens 55-59 22688402-12 2012 In contrast, the postoperative blood level of IL-6 in patients operated with DHS conv technique (78.41 +- 67.04 pg/ml) was on average higher than in patients operated by DHS MIO technique (39.02 +- 37.36 pg/ml), the mean difference being 39.39 pg/ml [95 % confidence interval (CI) 12.65-66.13 pg/ml; p = 0.0045]. dhs 77-80 interleukin 6 Homo sapiens 46-50 22565059-14 2012 CONCLUSIONS: The proportion of plasma phospholipid LA is inversely associated with IL-6 and all-cause mortality in Swedish dialysis patients. Phospholipids 38-50 interleukin 6 Homo sapiens 83-87 22527530-6 2012 To avoid dilution effects, urinary levels of IL-6 and IL-8 were expressed as the ratio of cytokine to urinary creatinine (pg/mg). Creatinine 110-120 interleukin 6 Homo sapiens 45-49 22695819-4 2012 Calcium imaging data indicated that IL-6 significantly suppressed high K(+)-induced intracellular Ca(2+) overload and LCC Ca(2+) influx. Calcium 0-7 interleukin 6 Homo sapiens 36-40 22743023-6 2012 High carbohydrate antigen 125 levels are closely related to the presence of serosal fluid and positively correlated with serum TNF-alpha, IL-6 and IL-10 levels in heart failure patients. Carbohydrates 5-17 interleukin 6 Homo sapiens 138-142 22909087-7 2012 The DMSO-soluble component curcumin, whose occurrence within the DMSO extract was verified by HPLC/MS, reduced levels of IL-1beta, IL-6, IL-8, MMP1, MMP3 and MMP13 and both caused an up-regulation of TNF-alpha. Curcumin 27-35 interleukin 6 Homo sapiens 131-135 22476617-9 2012 HepG2 cells incubated with 40 muM Fe alone or Fe/glucose and challenged with IL-6 and/or CoCl(2) showed increased IL-6, NF-kappaB, and TNF-alpha mRNA expression and decreased mRNA expression of Mfn-2 in all experimental conditions. Iron 34-36 interleukin 6 Homo sapiens 77-81 22476617-9 2012 HepG2 cells incubated with 40 muM Fe alone or Fe/glucose and challenged with IL-6 and/or CoCl(2) showed increased IL-6, NF-kappaB, and TNF-alpha mRNA expression and decreased mRNA expression of Mfn-2 in all experimental conditions. Glucose 49-56 interleukin 6 Homo sapiens 77-81 22476617-9 2012 HepG2 cells incubated with 40 muM Fe alone or Fe/glucose and challenged with IL-6 and/or CoCl(2) showed increased IL-6, NF-kappaB, and TNF-alpha mRNA expression and decreased mRNA expression of Mfn-2 in all experimental conditions. Glucose 49-56 interleukin 6 Homo sapiens 114-118 22762939-5 2012 Chlorojanerin was shown to be significantly effective in inhibiting TNF-alpha and IL-6 production in LPS-stimulated THP-1 cells (IC(50)=2.3+-0.2 muM and 1.8+-0.7 muM respectively). chlorojanerin 0-13 interleukin 6 Homo sapiens 82-86 22476617-9 2012 HepG2 cells incubated with 40 muM Fe alone or Fe/glucose and challenged with IL-6 and/or CoCl(2) showed increased IL-6, NF-kappaB, and TNF-alpha mRNA expression and decreased mRNA expression of Mfn-2 in all experimental conditions. Iron 34-36 interleukin 6 Homo sapiens 114-118 22476617-9 2012 HepG2 cells incubated with 40 muM Fe alone or Fe/glucose and challenged with IL-6 and/or CoCl(2) showed increased IL-6, NF-kappaB, and TNF-alpha mRNA expression and decreased mRNA expression of Mfn-2 in all experimental conditions. Iron 46-48 interleukin 6 Homo sapiens 77-81 22476617-9 2012 HepG2 cells incubated with 40 muM Fe alone or Fe/glucose and challenged with IL-6 and/or CoCl(2) showed increased IL-6, NF-kappaB, and TNF-alpha mRNA expression and decreased mRNA expression of Mfn-2 in all experimental conditions. Iron 46-48 interleukin 6 Homo sapiens 114-118 22527144-5 2012 Moreover, pretreatment with apigenin partially inhibited the DEHP-induced activation of c-Jun N-terminal kinase (JNK) but not the degradation of IkappaBalpha or the phosphorylation of extracellular-regulated kinase (ERK)1/2, indicating that the inhibitory effect of apigenin on the expression of IL-6, IL-8, and ICAM-1 may be mediated by JNK pathway but not IkappaBalpha/nuclear factor-kappaB or ERK/mitogen-activated protein kinase pathway. Apigenin 28-36 interleukin 6 Homo sapiens 296-300 22300324-7 2012 KEY RESULTS: TGF-beta (40-400 pM) reduced the maximum inhibitory effect of dexamethasone on IL-1alpha-induced IL-6 and CXCL8 production. Dexamethasone 75-88 interleukin 6 Homo sapiens 110-114 22883617-3 2012 Our central hypotheses were that, by the completion of treatment, serum iron would increase, serum concentrations of interleukin-6 (IL-6) and hepcidin-25, two mediators of hypoferremia, would decrease, and sputum iron would decrease. Iron 72-76 interleukin 6 Homo sapiens 132-136 22608565-6 2012 In this study, the established in-vitro sepsis model was confirmed by interleukin 6 (IL-6) levels at the proteomic and genomic levels by ELISA, real time-PCR and reactive oxygen species (ROS) activation by florescence staining. Reactive Oxygen Species 162-185 interleukin 6 Homo sapiens 85-89 22449275-10 2012 CONCLUSIONS: IL-6-634 polymorphism is associated with duration of oxygen therapy in VLBW infants. Oxygen 66-72 interleukin 6 Homo sapiens 13-17 22759480-12 2012 High concentrations of interleukin 6 were predictive of improved relative PFS benefit from pazopanib compared with placebo (p(interaction)=0 009); standard clinical classifications were not predictive of PFS benefit. pazopanib 91-100 interleukin 6 Homo sapiens 23-36 22213519-0 2012 Altered association of interleukin-6 with sex steroids in lipid metabolism disorder in men with prostate cancer receiving androgen deprivation therapy. Steroids 46-54 interleukin 6 Homo sapiens 23-36 22213519-1 2012 BACKGROUND: Interleukin-6 produced in adipose tissue plays a role in lipid metabolism, and also interacts with sex steroids. Steroids 115-123 interleukin 6 Homo sapiens 12-25 22213519-9 2012 CONCLUSIONS: Posttreatment interleukin-6 levels had a strong positive correlation with total-testosterone, androstenedione, and estradiol levels, suggesting that a regulation loop may emerge between these sex steroids and interleukin-6 during ADT. Estradiol 128-137 interleukin 6 Homo sapiens 222-235 22213519-9 2012 CONCLUSIONS: Posttreatment interleukin-6 levels had a strong positive correlation with total-testosterone, androstenedione, and estradiol levels, suggesting that a regulation loop may emerge between these sex steroids and interleukin-6 during ADT. Steroids 209-217 interleukin 6 Homo sapiens 27-40 22213519-2 2012 This study was performed to elucidate the mechanism of lipid metabolism disorder during androgen deprivation therapy (ADT) in terms of the association of interleukin-6 with sex steroids. Steroids 177-185 interleukin 6 Homo sapiens 154-167 22213519-10 2012 The altered association between interleukin-6 and sex steroids is possibly involved in ADT-related lipid metabolism disorder with unchanged interleukin-6 levels despite increased %body fat. Steroids 54-62 interleukin 6 Homo sapiens 32-45 22213519-4 2012 RESULTS: Before ADT, serum interleukin-6 levels were inversely correlated with serum total-testosterone (rs = -0.305, P = 0.009) and dihydrotestosterone (rs = -0.380, P = 0.006) concentrations, but not correlated with adrenal androgen or estradiol levels. Testosterone 91-103 interleukin 6 Homo sapiens 27-40 22213519-10 2012 The altered association between interleukin-6 and sex steroids is possibly involved in ADT-related lipid metabolism disorder with unchanged interleukin-6 levels despite increased %body fat. Steroids 54-62 interleukin 6 Homo sapiens 140-153 22213519-4 2012 RESULTS: Before ADT, serum interleukin-6 levels were inversely correlated with serum total-testosterone (rs = -0.305, P = 0.009) and dihydrotestosterone (rs = -0.380, P = 0.006) concentrations, but not correlated with adrenal androgen or estradiol levels. Estradiol 238-247 interleukin 6 Homo sapiens 27-40 22213519-7 2012 After ADT, in contrast to the pretreatment relationship, interleukin-6 levels were positively correlated with total-testosterone concentrations (rs = 0.343, P = 0.003), and were positively correlated also with levels of androstenedione (rs = 0.351, P = 0.002) and estoradiol (rs = 0.335, P = 0.004). Testosterone 116-128 interleukin 6 Homo sapiens 57-70 22213519-9 2012 CONCLUSIONS: Posttreatment interleukin-6 levels had a strong positive correlation with total-testosterone, androstenedione, and estradiol levels, suggesting that a regulation loop may emerge between these sex steroids and interleukin-6 during ADT. Testosterone 93-105 interleukin 6 Homo sapiens 27-40 22213519-9 2012 CONCLUSIONS: Posttreatment interleukin-6 levels had a strong positive correlation with total-testosterone, androstenedione, and estradiol levels, suggesting that a regulation loop may emerge between these sex steroids and interleukin-6 during ADT. Estradiol 128-137 interleukin 6 Homo sapiens 27-40 22931661-7 2012 After high dose DXM treatment, the levels of IFN-alpha, IL-6 and TNF-alpha decreased without significant difference compared with normal controls (P > 0.05). Dexamethasone 16-19 interleukin 6 Homo sapiens 56-60 22703874-0 2012 Synergistic inhibition of interleukin-6 production in adipose stem cells by tart cherry anthocyanins and atorvastatin. tart cherry anthocyanins 76-100 interleukin 6 Homo sapiens 26-39 22703874-0 2012 Synergistic inhibition of interleukin-6 production in adipose stem cells by tart cherry anthocyanins and atorvastatin. Atorvastatin 105-117 interleukin 6 Homo sapiens 26-39 22703874-2 2012 Both atorvastatin calcium (lipitor) as well as flavonoid rich fruit such as tart cherry demonstrate potent anti-inflammatory effects on IL-6 secretion. Atorvastatin 5-25 interleukin 6 Homo sapiens 136-140 22703874-2 2012 Both atorvastatin calcium (lipitor) as well as flavonoid rich fruit such as tart cherry demonstrate potent anti-inflammatory effects on IL-6 secretion. Atorvastatin 27-34 interleukin 6 Homo sapiens 136-140 22703874-5 2012 Furthermore, lipitor and C3G exhibited synergistic effects in reducing LPS-induced IL-6 secretion from adipose stem cells. Atorvastatin 13-20 interleukin 6 Homo sapiens 83-87 22768976-13 2012 CONCLUSIONS: HCV positive HD patients have low levels of serum prohepcidin and IL-6 which might account for iron accumulation together with lower iron and rhuEPO requirements in these patients. Iron 108-112 interleukin 6 Homo sapiens 79-83 22556270-3 2012 Secretion of proinflammatory cytokines such as interleukin-6 (IL-6), CXCL1 and CXCL5 from human lung fibroblasts was induced by cigarette-smoke carcinogen benzo[a]pyrene diol epoxide (BPDE), which was inhibited by a single dose of LDR. pyrene diol epoxide 163-182 interleukin 6 Homo sapiens 47-60 24049649-6 2012 Furthermore, calcium ionophore (A23187), which upregulates DUOX and NOX2 activities, strongly induced oxidative stress and IL-8 and IL-6 overexpression in IB3-1 cells. Calcium 13-20 interleukin 6 Homo sapiens 132-136 22556270-3 2012 Secretion of proinflammatory cytokines such as interleukin-6 (IL-6), CXCL1 and CXCL5 from human lung fibroblasts was induced by cigarette-smoke carcinogen benzo[a]pyrene diol epoxide (BPDE), which was inhibited by a single dose of LDR. pyrene diol epoxide 163-182 interleukin 6 Homo sapiens 62-66 22556270-3 2012 Secretion of proinflammatory cytokines such as interleukin-6 (IL-6), CXCL1 and CXCL5 from human lung fibroblasts was induced by cigarette-smoke carcinogen benzo[a]pyrene diol epoxide (BPDE), which was inhibited by a single dose of LDR. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 184-188 interleukin 6 Homo sapiens 47-60 22556270-4 2012 The activation of NF-kappaB, which is important for BPDE-induced IL-6 secretion, was also effectively suppressed by LDR. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 52-56 interleukin 6 Homo sapiens 65-69 22556270-5 2012 In addition, conditioned media from BPDE-treated fibroblasts activated STAT3 in the immortalized normal human bronchial epithelial cell line Beas-2B, which was blocked with an IL-6 neutralizing antibody. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 36-40 interleukin 6 Homo sapiens 176-180 22556270-7 2012 Furthermore, IL-6 enhanced BPDE-induced Beas-2B cell transformation in vitro. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 27-31 interleukin 6 Homo sapiens 13-17 22318941-10 2012 CONCLUSION: Based on these data, we conclude that gluconeogenesis is severely compromised in HCC by IL6-Stat3-mediated activation of miR-23a, which directly targets PGC-1alpha and G6PC, leading to decreased glucose production. Glucose 207-214 interleukin 6 Homo sapiens 100-103 22894740-9 2012 Correlation between ROS production and IL-6 releasing was observed. Reactive Oxygen Species 20-23 interleukin 6 Homo sapiens 39-43 22445541-3 2012 Here, we showed that staphylococcal LTA (Sa.LTA) substantially enhanced IL-6 expression at both the protein and the mRNA levels in the human basophil line, KU812, in the presence of a PKC activator (phorbol 12-myristrate 13-acetate; PMA), and a calcium ionophore (A23187), whereas Sa.LTA alone could not induce IL-6 expression. Tetradecanoylphorbol Acetate 233-236 interleukin 6 Homo sapiens 72-76 22445541-3 2012 Here, we showed that staphylococcal LTA (Sa.LTA) substantially enhanced IL-6 expression at both the protein and the mRNA levels in the human basophil line, KU812, in the presence of a PKC activator (phorbol 12-myristrate 13-acetate; PMA), and a calcium ionophore (A23187), whereas Sa.LTA alone could not induce IL-6 expression. Calcium 245-252 interleukin 6 Homo sapiens 72-76 22649193-7 2012 FICZ-exposed MCs produce reactive oxygen species and IL-6 in response to cAMP-dependent signals. Cyclic AMP 73-77 interleukin 6 Homo sapiens 53-57 22538414-6 2012 Pre-treatment with methyl-beta-cyclodextrin (MbetaCD), a cholesterol-binding agent, reduced IL-6 and IL-8 production in human gingival fibroblasts. methyl-beta-cyclodextrin 19-43 interleukin 6 Homo sapiens 92-96 22538414-6 2012 Pre-treatment with methyl-beta-cyclodextrin (MbetaCD), a cholesterol-binding agent, reduced IL-6 and IL-8 production in human gingival fibroblasts. methyl-beta-cyclodextrin 45-52 interleukin 6 Homo sapiens 92-96 22538414-6 2012 Pre-treatment with methyl-beta-cyclodextrin (MbetaCD), a cholesterol-binding agent, reduced IL-6 and IL-8 production in human gingival fibroblasts. Cholesterol 57-68 interleukin 6 Homo sapiens 92-96 22754038-8 2012 Oxygen desaturation index, hypoxia time, and minimum oxygen saturation (SaO2) significantly correlated with IL-6 and CRP levels, but apnea-hypopnea index did not. Oxygen 0-6 interleukin 6 Homo sapiens 108-112 22183741-7 2012 In addition, treatment of endometriotic stromal cells with curcumin markedly inhibited TNF-alpha-induced secretion of IL-6, IL-8 and MCP-1. Curcumin 59-67 interleukin 6 Homo sapiens 118-122 22197944-9 2012 EBLs from patients carrying the STAT3 "A" risk allele exhibited increased basal and IL-6-stimulated STAT3 tyrosine phosphorylation, increased transcription of STAT3 and SOCS3 after IL-6 stimulation, and increased membrane localization of the IL-6 receptor, GP130, and Janus-associated kinase 2. Tyrosine 106-114 interleukin 6 Homo sapiens 84-88 22475725-8 2012 In human colonic epithelial cells (T84 cells), COS treatment prevented NF-kappaB activation, production of TNF-alpha and IL-6, and loss of epithelial barrier integrity under both lipopolysaccharide (LPS) and TNF-alpha-stimulated conditions. carbonyl sulfide 47-50 interleukin 6 Homo sapiens 121-125 22133515-0 2012 Leptin and interleukin-6 alter the function of mesolimbic dopamine neurons in a rodent model of prenatal inflammation. Dopamine 58-66 interleukin 6 Homo sapiens 11-24 22943826-13 2012 Plasma ghrelin was positively correlated with TNFalpha and IL-6 in the underweight patients. Ghrelin 7-14 interleukin 6 Homo sapiens 59-63 22784287-7 2012 Volume priming in CPB for CABG patients using HA or HES preparation had less tendency for intense inflammatory response with lower levels of TNF-alpha, IL-1 beta , IL-6 and higher levels of IL-10 compared to patients treated with RS. Hydroxyethyl Starch Derivatives 52-55 interleukin 6 Homo sapiens 164-168 22147632-5 2012 RESULTS: Tofacitinib treatment of CD4+ T cells originating from synovium and peripheral blood inhibited the production of interleukin-17 (IL-17) and interferon-gamma (IFNgamma) in a dose-dependent manner, affecting both proliferation and transcription, but had no effect on IL-6 and IL-8 production. tofacitinib 9-20 interleukin 6 Homo sapiens 274-278 23019942-13 2012 The serum cortisol level was negatively correlated with serum TNF-alpha (r = -0.26, P = 0.03) and serum IL-6 (r = -0.25, P = 0.03). Hydrocortisone 10-18 interleukin 6 Homo sapiens 104-108 23019942-14 2012 The salivary cortisol level was negatively correlated with IL-6 in the induced sputum (r = -0.29, P = 0.02). Hydrocortisone 13-21 interleukin 6 Homo sapiens 59-63 22471522-3 2012 IL-6 treatment increased myeloma cell resistance to agents that induce oxidative stress, including IR (ionizing radiation) and Dex (dexamethasone). Dexamethasone 127-130 interleukin 6 Homo sapiens 0-4 22471522-3 2012 IL-6 treatment increased myeloma cell resistance to agents that induce oxidative stress, including IR (ionizing radiation) and Dex (dexamethasone). Dexamethasone 132-145 interleukin 6 Homo sapiens 0-4 22471522-5 2012 IL-6 combined with IR or Dex increased early intracellular pro-oxidant levels that were causally related to activation of NF-kappaB (nuclear factor kappaB) as determined by the ability of N-acetylcysteine to suppress both pro-oxidant levels and NF-kappaB activation. Acetylcysteine 188-204 interleukin 6 Homo sapiens 0-4 22471522-6 2012 In myeloma cells, upon combination with hydrogen peroxide treatment, relative to TNF (tumour necrosis factor)-alpha, IL-6 induced an early perturbation in reduced glutathione level and increased NF-kappaB-dependent MnSOD (manganese superoxide dismutase) expression. Hydrogen Peroxide 40-57 interleukin 6 Homo sapiens 117-121 22471522-6 2012 In myeloma cells, upon combination with hydrogen peroxide treatment, relative to TNF (tumour necrosis factor)-alpha, IL-6 induced an early perturbation in reduced glutathione level and increased NF-kappaB-dependent MnSOD (manganese superoxide dismutase) expression. Glutathione 163-174 interleukin 6 Homo sapiens 117-121 22471522-9 2012 The present study provides evidence that increases in MnSOD expression mediate IL-6-induced resistance to Dex and radiation in myeloma cells. Dexamethasone 106-109 interleukin 6 Homo sapiens 79-83 22147632-8 2012 Treatment of SCID-HuRAg mice with tofacitinib decreased serum levels of human IL-6 and IL-8 and markedly suppressed invasion of synovial tissue into cartilage. tofacitinib 34-45 interleukin 6 Homo sapiens 78-82 22147632-9 2012 CONCLUSION: Tofacitinib directly suppressed the production of IL-17 and IFNgamma and the proliferation of CD4+ T cells, resulting in inhibition of IL-6 production by RASFs and IL-8 production by CD14+ cells and decreased cartilage destruction. tofacitinib 12-23 interleukin 6 Homo sapiens 147-151 22429778-11 2012 Ocular irradiation from a Ru-106 plaque promoted an increase in the levels of IL-6, IL-8 and IL-1beta, modulation of which could be useful in managing radiation-related side effects. Ruthenium-106 26-32 interleukin 6 Homo sapiens 78-82 22275176-11 2012 Total and HDL cholesterol levels were negatively associated with C-reactive protein or serum interleukin-6 levels. Cholesterol 14-25 interleukin 6 Homo sapiens 93-106 22147632-7 2012 However, conditioned medium from CD4+ T cells cultured with tofacitinib inhibited IL-6 production by RASFs and IL-8 production by CD14+ monocytes. tofacitinib 60-71 interleukin 6 Homo sapiens 82-86 22116680-6 2012 It was concluded that dietary vanadium in excess of 30 mg/kg reduced the ileac T cell population and percentages of T cell subsets, and IL-2, IL-6, and IFN-gamma contents, implying that the immune function of local intestinal mucosa in broilers could be affected by the dietary vanadium. Vanadium 30-38 interleukin 6 Homo sapiens 142-146 21932058-2 2012 The study was tested in a fecal peritonitis-induced septic shock model, we observed that levosimendan combined with arginine vasopressin supplemented with norepinephrine therapy resulted in lower mean pulmonary artery pressure, lactate concentrations, arterial total nitrate/nitrite, and high-mobility group box 1 levels; decreased lung wet/dry ratio, and pulmonary levels of interleukin-6, total histological scores, and improved pulmonary gas exchange when compared with norepinephrine group. Norepinephrine 155-169 interleukin 6 Homo sapiens 376-389 22498762-12 2012 Curcumin also inhibited the TNF-alpha-induced production of IL-6/IL-8 in HaCaT cells. Curcumin 0-8 interleukin 6 Homo sapiens 60-64 22648259-5 2012 It was also reported that hydrogen could suppress the levels of TNF-alpha and IL-6. Hydrogen 26-34 interleukin 6 Homo sapiens 78-82 22386451-12 2012 The tSOFA score at 2 weeks post-LVAD and ICU duration were related with pre-implant IL-6 levels. lvad 32-36 interleukin 6 Homo sapiens 84-88 22349668-7 2012 After 12 weeks of intervention, vitamin D supplementation for group I infants caused significant improvement of HF score, left-ventricular (LV) end-diastolic diameter, LV end-systolic diameter, LV ejection fraction%, and myocardial performance index together with markedly increased serum 25(OH)D and interleukin (IL)-10 and decreased PTH, IL-6, and TNF-alpha compared with the placebo group; these differences were statistically significant (p < 0.001). Vitamin D 32-41 interleukin 6 Homo sapiens 340-344 22041018-11 2012 This increase in VEGF and IL6 was blocked by the ROS scavenger N-acetyl cysteine (NAC). Reactive Oxygen Species 49-52 interleukin 6 Homo sapiens 26-29 21932426-8 2012 Elevated IL-6 levels before vaccination was an unfavorable factor for OS of DBC-resistant CRPC patients (P = 0.0161, hazard ratio (HR): 0.024, 95% CI:0.001-0.499) as well as all 42 patients with PPV(P = 0.0011, HR: 0.212, 95% CI:0.068-0.661) by multivariable analysis. dbc 76-79 interleukin 6 Homo sapiens 9-13 22059850-6 2012 RESULTS: Short-chain fatty acids, at 20 mM, induced interleukin (IL)-8, IL-6, and IL-1beta release, while lower levels (0.02-2 mM) did not induce cytokine secretion. Fatty Acids, Volatile 9-32 interleukin 6 Homo sapiens 72-76 22932481-0 2012 [17-beta estradiol promotes the expression of interleukin-6 in human periodontal ligament cells infected with Porphyromonas gingivalis]. Estradiol 1-18 interleukin 6 Homo sapiens 46-59 22041018-11 2012 This increase in VEGF and IL6 was blocked by the ROS scavenger N-acetyl cysteine (NAC). Acetylcysteine 63-80 interleukin 6 Homo sapiens 26-29 22041018-11 2012 This increase in VEGF and IL6 was blocked by the ROS scavenger N-acetyl cysteine (NAC). Acetylcysteine 82-85 interleukin 6 Homo sapiens 26-29 22041018-12 2012 CONCLUSION: The regulatory effect of rhBMP-2 on angiogenesis and inflammation is mediated through a ROS-dependent mechanism, which involves upregulation of crucial angiogenic and inflammatory mediators such as VEGF and IL6. Reactive Oxygen Species 100-103 interleukin 6 Homo sapiens 219-222 22420891-10 2012 CONCLUSIONS: Moderate alcohol consumption is associated with lower levels of IL-6 and (to a lesser degree) of TNF-alpha, irrespective of the type of alcohol consumed. Alcohols 22-29 interleukin 6 Homo sapiens 77-81 22287454-6 2012 We observed that Ni(II) did not alter the levels of secreted TNFalpha from activated monocytes, but increased secreted IL6 levels about 30% over controls. Nickel(2+) 17-23 interleukin 6 Homo sapiens 119-122 22420891-5 2012 Low and moderate alcohol consumption led to lower IL-6 levels: median (interquartile range) 1.47 (0.70-3.51), 1.41 (0.70-3.32), 1.42 (0.66-3.19) and 1.70 (0.83-4.39) pg/ml for nondrinkers, low, moderate and high drinkers, respectively, p<0.01, but this association was no longer significant after multivariate adjustment. Alcohols 17-24 interleukin 6 Homo sapiens 50-54 21978796-8 2012 Plasma IL-6 was lower on days 4-5 (p<0.05), IL-8 on days 4-6 (p<0.05) and IL-10 on days 4-6 (p<0.05) in NAC group. Acetylcysteine 113-116 interleukin 6 Homo sapiens 7-11 22726350-3 2012 ST, rosmarinic acid, pulegone, and 2alpha,3alpha,24-thrihydrooxylen-12en-28oic acid treatment of HMC-1 cells led to significant suppression of pro-inflammatory cytokines (IL-6, IL-8, and TNF-alpha) in a dose dependent manner. rosmarinic acid 4-19 interleukin 6 Homo sapiens 171-175 21958081-8 2012 Decanoyl carnitine positively correlated with oxidized LDL, 8-epi-PGF(2alpha), IL-6, TNF-alpha and ba-PWV. decanoylcarnitine 0-18 interleukin 6 Homo sapiens 79-83 22367719-6 2012 Induced vascular permeability, oedema formation, release of TNF-alpha and IL-6 and pulmonary leukocyte recruitment were all markedly reduced by GW280264X or endothelial adam17-knockout. GW280264X 144-153 interleukin 6 Homo sapiens 74-78 22503683-0 2012 Antagonistic effect of disulfide-rich peptide aptamers selected by cDNA display on interleukin-6-dependent cell proliferation. Disulfides 23-32 interleukin 6 Homo sapiens 83-96 21954831-0 2012 Interleukin-6 autocrine signaling mediates melatonin MT(1/2) receptor-induced STAT3 Tyr(705) phosphorylation. Tyrosine 85-88 interleukin 6 Homo sapiens 0-13 21954831-7 2012 Antibody against IL-6, but not those for GM-CSF and CXCL-8, effectively abolished the agonist-induced STAT3 Tyr(705) phosphorylation, suggesting the involvement of IL-6 in melatonin receptor-mediated STAT3 activation. Tyrosine 108-111 interleukin 6 Homo sapiens 17-21 22386961-7 2012 Endogenous differences between the cells showed that the CyT expressed more RLN, its receptor RXFP1 and the RXFP1 splice variant D. CyT also showed the most robust cAMP response to RLN with increased IL6 secreted after 4 h, preceded by increased transcription at 1 h, likely due to activation of RXFP1 and cAMP. Cyclic AMP 164-168 interleukin 6 Homo sapiens 200-203 22386961-7 2012 Endogenous differences between the cells showed that the CyT expressed more RLN, its receptor RXFP1 and the RXFP1 splice variant D. CyT also showed the most robust cAMP response to RLN with increased IL6 secreted after 4 h, preceded by increased transcription at 1 h, likely due to activation of RXFP1 and cAMP. Cyclic AMP 306-310 interleukin 6 Homo sapiens 200-203 22284606-6 2012 We report here a case of effective interleukin-6 blocker in the treatment of refractory giant cell arteritis with ileitis and high-dose steroid dependence despite 2 years of treatment with steroids and methotrexate. Steroids 136-143 interleukin 6 Homo sapiens 35-48 22284606-6 2012 We report here a case of effective interleukin-6 blocker in the treatment of refractory giant cell arteritis with ileitis and high-dose steroid dependence despite 2 years of treatment with steroids and methotrexate. Steroids 189-197 interleukin 6 Homo sapiens 35-48 22503683-5 2012 The results revealed that a disulfide-rich peptide aptamer inhibited IL-6-dependent cell proliferation with similar efficacy to an anti-IL-6R monoclonal antibody. Disulfides 28-37 interleukin 6 Homo sapiens 69-73 21849239-1 2012 AIM: To examine the effects of ibuprofen used for patent ductus arteriosus (PDA) treatment on the production of the proinflammatory cytokines C-reactive protein (CRP) and interleukin 6 (IL-6) in preterm septic newborns. Ibuprofen 31-40 interleukin 6 Homo sapiens 171-184 22745145-9 2012 CONCLUSION: short-term oral NAC treatment resulted in reduction of circulating PCT, IL-6, IL-1, C3, sICAM, hsCRP, and TNF- in CAPD patients. Acetylcysteine 28-31 interleukin 6 Homo sapiens 84-88 22460142-7 2012 Tofacitinib reduced serum levels of human IL-6 and IL-8 in the mice and also reduced synovial inflammation and invasion into the implanted cartilage. tofacitinib 0-11 interleukin 6 Homo sapiens 42-46 22087578-7 2012 Adding WHI-P131 or PD98059 decreased IL-6 and sIL-6r enhancement of MMP-1, -3 and -13. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 19-26 interleukin 6 Homo sapiens 37-41 22095388-9 2012 Cells pretreated with nicotine prior to lipopolysaccharide (LPS) stimulation exhibited a lower production of TNF-alpha, IL-8, and IL-6 compared to LPS-treated (only) cells. Nicotine 22-30 interleukin 6 Homo sapiens 130-134 22095388-10 2012 Cells that were transfected with alpha7 siRNA and subsequently incubated with nicotine and LPS, exhibited a higher expression of TNF-alpha, IL-8, and IL-6 compared with non-transfected cells or alpha1 and alpha5 siRNA-transfected cells. Nicotine 78-86 interleukin 6 Homo sapiens 150-154 21849239-7 2012 CONCLUSIONS: IL-6 and CRP may decrease in infants receiving ibuprofen treatment more than infants who do not receive it. Ibuprofen 60-69 interleukin 6 Homo sapiens 13-17 22151118-4 2012 Our objective was to study whether melatonin interferes in the desmoplastic reaction by regulating some factors secreted by malignant cells, tumor necrosis factor (TNF)-alpha, interleukin (IL)-11, and interleukin (IL)-6. Melatonin 35-44 interleukin 6 Homo sapiens 201-219 21951103-5 2012 On the other hand, melatonin regulates circadian rhythm homeostasis in humans and has many other effects, which include antioxidant and anti-inflammatory effects, as demonstrated by the reduced expressions of iNOS, IL-1beta, and IL-6 and increased glutathione (GSH) and superoxide dismutase activities. Melatonin 19-28 interleukin 6 Homo sapiens 229-233 22528216-9 2012 Moreover, the expression of SDF-1alpha, VEGF and IL-6 in MSC-CdM(HYP) group was up-regulated. Chlorphenamidine 61-64 interleukin 6 Homo sapiens 49-53 22151118-10 2012 One millimolar melatonin induced a reduction in TNF-alpha, IL-6, and IL-11 mRNA expression in MCF-7 and 3T3-L1 cells. Melatonin 15-24 interleukin 6 Homo sapiens 59-63 22264996-9 2012 Pain thresholds correlated with interleukin 6 at +1h (r=0.60, P<.05) and +3h (r=0.67, P<.05) within the LPS condition. Hydrogen 50-52 interleukin 6 Homo sapiens 32-45 21895822-10 2012 In multiple linear regressions adjusting for age, waist circumference and smoking, independent correlations between oxygen desaturation indices (ODI) and inflammation were found for IL-6 (P = 0.03 for % sleep time with saturation <90%) and TNFalpha (P = 0.03 for ODI 3%). Oxygen 116-122 interleukin 6 Homo sapiens 182-186 22536561-5 2012 TNF-alpha and IL-6 levels were also correlated with fasting plasma glucose of obese and nonobese diabetic patients after insulin therapy. Glucose 67-74 interleukin 6 Homo sapiens 14-18 21633399-8 2012 The oral glucose challenge was associated with a significant increase in the expression of inflammatory cytokines, including interleukin (IL)-1alpha/beta, IL-6, and IL-8, that may result from ER stress. Glucose 9-16 interleukin 6 Homo sapiens 155-159 22334674-4 2012 Depletion of lipin-2 promotes the increased expression of the proinflammatory genes Il6, Ccl2, and Tnfalpha, which depends on the overstimulation of the JNK1/c-Jun pathway by saturated fatty acids. Fatty Acids 175-196 interleukin 6 Homo sapiens 84-87 22392142-7 2012 On the other hand, N-acetyl-L-cysteine decreased mRNA stability of ICAM-1 and IL-6 in LPS-treated cells and IL-6 and ICAM-1 in TNF-alpha-treated cells. Acetylcysteine 19-38 interleukin 6 Homo sapiens 78-82 22392142-7 2012 On the other hand, N-acetyl-L-cysteine decreased mRNA stability of ICAM-1 and IL-6 in LPS-treated cells and IL-6 and ICAM-1 in TNF-alpha-treated cells. Acetylcysteine 19-38 interleukin 6 Homo sapiens 108-112 22406269-2 2012 Here, we showed that in vitro Th17 cells generated with the cytokines IL-6 and TGF-beta expressed CD39 and CD73 ectonucleotidases, leading to adenosine release and the subsequent suppression of CD4(+) and CD8(+) T cell effector functions. Adenosine 142-151 interleukin 6 Homo sapiens 70-74 22421339-6 2012 To gain insight into possible mechanisms, we assessed Asp358Ala in relation to localised gene expression and to postlipopolysaccharide stimulation of interleukin 6. postlipopolysaccharide 112-134 interleukin 6 Homo sapiens 150-163 22420994-0 2012 Involvement of metabotropic glutamate receptor 5, AKT/PI3K signaling and NF-kappaB pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes. Methamphetamine 94-109 interleukin 6 Homo sapiens 131-135 22285171-7 2012 Dexamethasone pretreatment prior to LPS exposure significantly decreased IL-6 and IL-8 levels in both cell lines. Dexamethasone 0-13 interleukin 6 Homo sapiens 73-77 21737151-3 2012 The total anti-oxidation capacity and SOD activity were decreased while the serum H(2)O(2) level and XO activity were elevated in groups with higher CRP or IL-6 level. Hydrogen Peroxide 82-90 interleukin 6 Homo sapiens 156-160 22289904-6 2012 RESULTS: Pretreatment with dexamethasone led to a significant decrease in myocardial expression of IL-6, IL-8, IL-1beta, and TNF-alpha messenger RNA and to a decrease in protein synthesis of TNF-alpha. Dexamethasone 27-40 interleukin 6 Homo sapiens 99-103 22121136-5 2012 RESULTS: Interleukin-6-induced phosphorylation of STAT1 and STAT3 was inhibited by CP-690,550 with IC(50) values of 23 and 77 nM, respectively. tofacitinib 83-89 interleukin 6 Homo sapiens 9-22 22155371-7 2012 Hyperglycemia-induced enhanced levels of VEGF, ICAM-1, MCP-1 and IL-6 in the plasma of STZ treated animals indicate vascular inflammation in T1DM. Streptozocin 87-90 interleukin 6 Homo sapiens 65-69 22226857-4 2012 Moreover, we found that DEM pretreatment enhanced the production of IL-6 induced by TNF-alpha. diethyl malate 24-27 interleukin 6 Homo sapiens 68-72 21907687-11 2012 Lipid accumulation in hepatocytes, induced by incubation with fatty acids, was associated with increased CML formation and expression of the receptor for advanced glycation endproducts (RAGE), PAI-1, IL-8, IL-6, and CRP. Fatty Acids 62-73 interleukin 6 Homo sapiens 206-210 22066570-7 2012 Morphine enhanced IL-6 secretion and blunted MCP-2 secretion from HIV-infected h-mdms. Morphine 0-8 interleukin 6 Homo sapiens 18-22 22066570-10 2012 Morphine had a potentially additive effect on the HIV-induced production of IL-6 and delayed HIV-induced MCP-2 production. Morphine 0-8 interleukin 6 Homo sapiens 76-80 21730965-8 2012 At baseline, C(-) carriers of IL-6 polymorphism had a significantly higher RMR (P<0.05), free FM (kg), but less total and trunk FM (%), higher body cell mass (BCM), content of TBW (L) and ECW (extracellular water)/ICW ratio compared with C(+) carriers (P<0.001). Water 210-215 interleukin 6 Homo sapiens 30-34 21894159-5 2012 RESULTS: Patients with the Gly482Ser polymorphism had significantly improved reductions in the waist/hip ratio, fasting blood glucose, C-reactive protein, blood leukocyte count, serum interleukin-6 and intima-media thickness of the carotid artery, as compared with Gly/Gly patients. Glycine 27-30 interleukin 6 Homo sapiens 184-197 22320924-5 2012 Recent studies have suggested that IL-10 may play a dual role in controlling ethanol-induced steatosis and liver injury via the inhibition of the pro-inflammatory cytokine TNF-alpha, thereby ameliorating alcoholic liver injury, or via the inhibition of the hepatoprotective cytokine IL-6, thereby potentiating alcoholic liver injury. Ethanol 77-84 interleukin 6 Homo sapiens 283-287 22066570-6 2012 Chronic morphine exposure of HIV-infected h-mdms led to significant alterations in the secretion of IL-6 and monocyte chemoattractant protein 2 (MCP-2). Morphine 8-16 interleukin 6 Homo sapiens 100-104 22260656-4 2012 We have been investigating novel cAMP-regulated pathways that combat the action of pro-inflammatory cytokines, such as IL-6 and leptin, in the VECs (vascular endothelial cells) of the circulatory system. Cyclic AMP 33-37 interleukin 6 Homo sapiens 119-123 21879314-4 2012 Elevated IL-6 and soluble IL-6R levels in Ala carriers may have negative impact on acquiring verbal cognitive ability requiring long-term memory. Alanine 42-45 interleukin 6 Homo sapiens 9-13 22309277-9 2012 CRSwNP cultures were more sensitive than controls to dexamethasone (1 microg/ml) dependent IL-6 and IL-8 suppression. Dexamethasone 53-66 interleukin 6 Homo sapiens 91-95 22109853-3 2012 The release of dopamine (DA) and norepinephrine (NE) by PC12 was significantly inhibited after CM treatment (P < 0.05), similar to what happened after recombinant interleukin 6(IL-6) treatment. Dopamine 15-23 interleukin 6 Homo sapiens 166-179 21952131-6 2012 In addition, URB597 tended to enhance and reduce the LPS-induced increase in IL-6 and IL-10 mRNA expression, respectively. cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester 13-19 interleukin 6 Homo sapiens 77-81 22052073-10 2012 Furthermore, 8-OHdG/creatinine correlated with TNF-alpha, sTNF-R1, sTNF-R2 (P < 0.0001), and with IL-6 (P < 0.05). Creatinine 20-30 interleukin 6 Homo sapiens 101-105 22348735-13 2012 CONCLUSIONS: IL-6, IL-10 and LBP concentrations were increased in patients with a CRB-65 score of 3-4 and a severe course of CAP. cap 125-128 interleukin 6 Homo sapiens 13-17 22374671-4 2012 Stimulating TIG3 fibroblast cells with IL-6/sIL-6R sequentially caused an increase in reactive oxygen species (ROS) as early as day 1, followed by the DNA damage response, p53 accumulation and, finally, senescence on days 8-10. Reactive Oxygen Species 86-109 interleukin 6 Homo sapiens 39-43 22374671-4 2012 Stimulating TIG3 fibroblast cells with IL-6/sIL-6R sequentially caused an increase in reactive oxygen species (ROS) as early as day 1, followed by the DNA damage response, p53 accumulation and, finally, senescence on days 8-10. Reactive Oxygen Species 111-114 interleukin 6 Homo sapiens 39-43 23565120-0 2012 The effect of alcohol use on IL-6 responses across different racial/ethnic groups. Alcohols 14-21 interleukin 6 Homo sapiens 29-33 22428468-10 2012 Fasting plasma glucose (FPG) level and HbA1c showed a significant positive correlation (p < 0.001) with Hs-CRP (r = 0.531) (r = 0.750), and IL-6 (r = 0. Glucose 15-22 interleukin 6 Homo sapiens 143-147 22030090-3 2012 Treatment with curcumin in the diet or by intraperitoneal injection significantly inhibited tumorigenicity and tumor growth, decreased the percentages of MDSCs in the spleen, blood, and tumor tissues, reduced interleukin (IL)-6 levels in the serum and tumor tissues in a human gastric cancer xenograft model and a mouse colon cancer allograft model. Curcumin 15-23 interleukin 6 Homo sapiens 209-227 22030090-5 2012 Curcumin treatment inhibited the expansion of MDSCs, the activation of Stat3 and NF-kappaB in MDSCs, and the secretion of IL-6 by MDSCs, when MDSCs were cultured in the presence of IL-1beta, or with cancer cell- or myofibroblast-conditioned medium. Curcumin 0-8 interleukin 6 Homo sapiens 122-126 22236003-5 2012 We examined the inhibitory effects of the amino acids cysteine, histidine and glycine on the induction of NF-kappaB activation, expression of CD62E (E-selectin) and the production of interleukin (IL)-6 in HCAECs stimulated with tumour necrosis factor (TNF)-alpha. Glycine 78-85 interleukin 6 Homo sapiens 183-201 22236003-8 2012 Our results show that glycine, histidine and cysteine can inhibit NF-kappaB activation, IkappaBalpha degradation, CD62E expression and IL-6 production in HCAECs, suggesting that these amino acids may exhibit anti-inflammatory effects during endothelial inflammation. Glycine 22-29 interleukin 6 Homo sapiens 135-139 22236003-8 2012 Our results show that glycine, histidine and cysteine can inhibit NF-kappaB activation, IkappaBalpha degradation, CD62E expression and IL-6 production in HCAECs, suggesting that these amino acids may exhibit anti-inflammatory effects during endothelial inflammation. Histidine 31-40 interleukin 6 Homo sapiens 135-139 22236003-8 2012 Our results show that glycine, histidine and cysteine can inhibit NF-kappaB activation, IkappaBalpha degradation, CD62E expression and IL-6 production in HCAECs, suggesting that these amino acids may exhibit anti-inflammatory effects during endothelial inflammation. Cysteine 45-53 interleukin 6 Homo sapiens 135-139 22332661-5 2012 RESULTS: Fractional exhaled nitric oxide increased in association with lower promoter methylation of both IL-6 (+29.0%; p = 0.004) and iNOS (+41.0%; p = 0.002). Nitric Oxide 28-40 interleukin 6 Homo sapiens 106-110 23565120-3 2012 PARTICIPANTS METHODS: A clinic-based case-control study was designed to elucidate the plausible effects of alcohol use on IL-6. Alcohols 107-114 interleukin 6 Homo sapiens 122-126 23565120-5 2012 RESULTS: Stimulated peripheral blood mononuclear cells produced significantly higher amounts of IL-6 in hazardous alcohol users compared with nonhazardous alcohol users. Alcohols 114-121 interleukin 6 Homo sapiens 96-100 23565120-8 2012 A distinctive IL-6 production pattern across racial/ethnic groups was also evident and showed that, when prescribed HAART, Hispanic hazardous alcohol users have a particularly high risk of morbidity compared with their Caucasian and African-American counterparts. Alcohols 142-149 interleukin 6 Homo sapiens 14-18 21347606-9 2012 Dopamine doses were positively associated with IL-6, and norepinephrine was inversely associated with IL-8 and TNF-alpha levels. Dopamine 0-8 interleukin 6 Homo sapiens 47-51 21347606-11 2012 Dobutamine treatment may contribute to circulating TNF-alpha and dopamine to IL-6, independently of activated neutrophils. Dopamine 65-73 interleukin 6 Homo sapiens 77-81 23565120-9 2012 After adjusting for confounders (e.g., sociodemographics and HIV disease status), regression analyses confirmed that chronic inflammation, as indicated by IL-6 levels (log), is associated with alcohol use, race/ethnicity and thrombocytopenia, and tended to be related to concurrent smoking. Alcohols 193-200 interleukin 6 Homo sapiens 155-159 22232416-7 2012 Histamine-induced reduction of CD1a(+) DCs is associated with increased secretion of IL-6 and IL-10, up-regulation of a typical combination of chemokines, expression C5aR1 by the CD1a(-) DC subset and enhanced migration of both activated DC subsets supported by the production of MMP-9 and MMP-12 enzymes. Histamine 0-9 interleukin 6 Homo sapiens 85-89 21494800-8 2012 Nicotine upregulated OPN, IL-6, and MCP-1 expressions, and this effect attenuated after PDTC pretreatment. Nicotine 0-8 interleukin 6 Homo sapiens 26-30 22154464-9 2012 Interestingly, estradiol decreases IL-6 expression thereby increasing the anti-DNA response. Estradiol 15-24 interleukin 6 Homo sapiens 35-39 22324945-12 2012 Signal transducer and activator of transcription 3 (STAT3) inhibitor parthenolide inhibited the effect of IL-6/sIL-6R on ADAMTS-4, and downregulated ADAMTS-5 expression. parthenolide 69-81 interleukin 6 Homo sapiens 106-110 21979104-10 2012 Moreover, IL-6 ELF level in the dependent lung was significantly higher in the propofol group than in the sevoflurane group after OLV (P < 0.001). Sevoflurane 106-117 interleukin 6 Homo sapiens 10-14 22118570-5 2012 Resveratrol preferentially inhibited nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) activation upon LPS stimulation by interfering with IKK and IkappaB phosphorylation, an effect that potently reduced the transcriptional stimulation of several NF-kappaB target genes, including tumor necrosis factor-alpha and interleukin-6. Resveratrol 0-11 interleukin 6 Homo sapiens 338-351 21809384-4 2012 Effects of short-term treatment with IL-alpha, IL-6, or IL-8 on endogenous GTP-bound Cdc42 levels were assessed using an affinity assay, and on actin filament organization using confocal microscopy. Guanosine Triphosphate 75-78 interleukin 6 Homo sapiens 47-51 21809384-6 2012 Short exposure to IL-1alpha, IL-6, or IL-8 decreased endogenous GTP-Cdc42 and increased stress fibers, which were reversed with cytochalasin D treatment. Guanosine Triphosphate 64-67 interleukin 6 Homo sapiens 29-33 22209282-7 2012 RESULTS: Compared to vehicle, topical cholesterol significantly decreased the degree of dermal inflammatory infiltrates and exocytosis, and also decreased the expression of MMP-1, IL-6, and IL-1ss mRNA. Cholesterol 38-49 interleukin 6 Homo sapiens 180-184 22209282-8 2012 In contrast, topical linoleic acid increased the induction of apoptotic cells, and the expression of MMP-1 and IL-6 mRNA. Linoleic Acid 21-34 interleukin 6 Homo sapiens 111-115 22118570-8 2012 Resveratrol treatment also prevented the pro-inflammatory effect of fibrillar Abeta on macrophages by potently inhibiting the effect of Abeta on IkappaB phosphorylation, activation of STAT1 and STAT3, and on tumor necrosis factor-alpha and interleukin-6 secretion. Resveratrol 0-11 interleukin 6 Homo sapiens 240-253 22045589-3 2012 In this study, we demonstrated that human BMSCs express H1, H2, and H4 histamine receptors and they respond to histamine stimulation with an increased interleukin 6 (IL-6) production both in vitro and in vivo. Histamine 71-80 interleukin 6 Homo sapiens 151-164 22045589-3 2012 In this study, we demonstrated that human BMSCs express H1, H2, and H4 histamine receptors and they respond to histamine stimulation with an increased interleukin 6 (IL-6) production both in vitro and in vivo. Histamine 71-80 interleukin 6 Homo sapiens 166-170 22045589-5 2012 When BMSCs were pretreated with either histamine or degranulated human mast cells, they exhibited an enhanced IL-6-dependent antiapoptotic effect on neutrophil granulocytes. Histamine 39-48 interleukin 6 Homo sapiens 110-114 22142850-3 2012 Here we show that exposure of human airway epithelial cells to cadmium promotes a polarized apical secretion of IL-6 and IL-8, two pivotal pro-inflammatory cytokines known to play an important role in pulmonary inflammation. Cadmium 63-70 interleukin 6 Homo sapiens 112-116 22280969-9 2012 Interleukin (IL)-6-induced phosphorylation of STAT3 at Tyr-705 was significantly blocked by DIM. Tyrosine 55-58 interleukin 6 Homo sapiens 0-18 22178606-6 2012 HG-induced expression of TNF-alpha, IL-6, IL-1beta, IL-4, and VEGF was blocked by ROS scavenger and inhibitors specific for NF-kappaB and STAT 3, respectively. Reactive Oxygen Species 82-85 interleukin 6 Homo sapiens 36-40 22142850-4 2012 We also determined that two distinct pathways controlled secretion of these proinflammatory cytokines by human airway epithelial cells as cadmium-induced IL-6 secretion occurs via an NF-kappaB dependent pathway, whereas IL-8 secretion involves the Erk1/2 signaling pathway. Cadmium 138-145 interleukin 6 Homo sapiens 154-158 22142850-5 2012 Interestingly, the natural antioxidant curcumin could prevent both cadmium-induced IL-6 and IL-8 secretion by human airway epithelial cells. Curcumin 39-47 interleukin 6 Homo sapiens 83-87 22142850-5 2012 Interestingly, the natural antioxidant curcumin could prevent both cadmium-induced IL-6 and IL-8 secretion by human airway epithelial cells. Cadmium 67-74 interleukin 6 Homo sapiens 83-87 22910558-4 2012 Secretion of the pro-inflammatory cytokines, IL-6 and TNF-alpha, was significantly attenuated in calcitriol-treated VSMC culture, but the level of anti-inflammatory TGF-beta was generally unchanged. vsmc 116-120 interleukin 6 Homo sapiens 45-49 23227796-6 2012 In addition, AMC decreased gene expression and secretion of proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-8 in human mast cells. 7-amino-4-methylcoumarin 13-16 interleukin 6 Homo sapiens 129-147 22211683-5 2012 Ingestion of HFM-P induced an inflammatory response mediated by TNF-alpha (p < 0.001), IL-6 (p < 0.001) and IL-17 (p < 0.01). hfm-p 13-18 interleukin 6 Homo sapiens 90-94 22086137-9 2012 Our results show that high glucose concentrations (12 mM and particularly 24 mM) alter the biomineralization process in osteoblastic cells and provoke the following: i) a rise in mineralization, ii) an increase in the mRNA expression of RANKL and a decrease of OPG, iii) an increase in the mRNA expression of osteocalcin, bone sialoprotein and the transcription factor Runx2, iv) a diminished quality of the mineral, and v) an increase in the expression of IL1beta, IL6, IL8, MCP-1 and IL10 mRNAs. Glucose 27-34 interleukin 6 Homo sapiens 466-469 22132896-13 2012 Finally, inflammatory cytokines, such as tumour necrosis factor (TNF)-alpha and interleukin (IL)-6, showed lower levels in the graft of those animals that had been pretreated with rapamycin or tacrolimus. Sirolimus 180-189 interleukin 6 Homo sapiens 80-98 22035595-5 2012 Our data indicated that diabetes as whole was strongly associated with elevated levels of IL-6, leptin, CRP and TNF-alpha, whereas worsening of glucose control was positively and linearly associated with high levels of IL-6, and leptin. Glucose 144-151 interleukin 6 Homo sapiens 219-223 23183248-0 2012 Nitric oxide activates IL-6 production and expression in human renal epithelial cells. Nitric Oxide 0-12 interleukin 6 Homo sapiens 23-27 23885401-2 2012 The cholestatic effect of cytokines (e.g. IL-1beta, IL-6) is believed to result from the repression of genes that normally mediated the hepatic uptake, metabolism, and biliary excretion of bile salts and bilirubin. Bile Acids and Salts 189-199 interleukin 6 Homo sapiens 52-56 22284780-11 2012 Specifically, apiegenin, baicalein, curcumin, EGCG, genistein, luteolin, oridonin, quercetin, and wogonin repress NF-kappaB (NF-kappaB, a proinflammatory transcription factor) and inhibit proinflammatory cytokines such as TNF-alpha and IL-6. Curcumin 36-44 interleukin 6 Homo sapiens 236-240 22110547-7 2012 In addition, EBNE-induced production of IL-6 and VEGF was inhibited by PD98059 (a p44/42 MAPK inhibitor), SB203580 (a p38 MAPK inhibitor), and PDTC (a NF-kappaB inhibitor), but not SP600125 (a JNK inhibitor). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 71-78 interleukin 6 Homo sapiens 40-44 22153537-8 2012 PAI-1 and IL-6 were significantly correlated with mean arterial pressure, BMI, uric acid, total and LDL-cholesterol. Cholesterol 104-115 interleukin 6 Homo sapiens 10-14 23164989-0 2012 Effect of standard anthracycline based neoadjuvant chemotherapy on circulating levels of serum IL-6 in patients of locally advanced carcinoma breast - a prospective study. Anthracyclines 19-32 interleukin 6 Homo sapiens 95-99 22067128-7 2012 There were increased levels of IL-1beta, IL-6, MMP-1, MMP-3, and MMP-9 and decreased levels of TIMP-1 and TIMP-2 in the tears of PG-treated patients. Prostaglandins 129-131 interleukin 6 Homo sapiens 41-45 22284696-13 2012 In conclusion, IL-6, but not CRP, is a strong predictor of ESA hyporesponsiveness in hemodialysis patients who have sufficient iron. Iron 127-131 interleukin 6 Homo sapiens 15-19 23204851-15 2012 Interestingly, compared with baseline inflammatory cytokine levels in those with the Val/Val genotype, higher baseline tumor necrosis factor alpha, interleukin-6, and C-reactive protein levels were observed for the Ala/Ala genotype in both patients with carotid atherosclerosis and healthy controls. Alanine 215-218 interleukin 6 Homo sapiens 148-161 22021706-6 2012 In vitro, high glucose induced TLR4 expression via protein kinase C activation in a time- and dose-dependent manner, resulting in upregulation of IL-6 and chemokine (C-C motif) ligand 2 (CCL-2) expression via IkappaB/NF-kappaB activation in human proximal tubular epithelial cells. Glucose 15-22 interleukin 6 Homo sapiens 146-185 22102722-5 2012 Both P2Y(6)-specific antagonist and P2Y(6) antisense oligonucleotides significantly inhibited the production of IL-1alpha, IL-8/CXCL8, and IL-6 by NHK. Oligonucleotides 53-69 interleukin 6 Homo sapiens 139-143 22801289-4 2012 Elevated IL-6 was associated with higher nicotine use. Nicotine 41-49 interleukin 6 Homo sapiens 9-13 23204851-15 2012 Interestingly, compared with baseline inflammatory cytokine levels in those with the Val/Val genotype, higher baseline tumor necrosis factor alpha, interleukin-6, and C-reactive protein levels were observed for the Ala/Ala genotype in both patients with carotid atherosclerosis and healthy controls. Alanine 219-222 interleukin 6 Homo sapiens 148-161 22605923-6 2012 Pretreatment with 10(-10) M 17-beta-estradiol greatly inhibited the increased expression and production of IL-6, IL-1, and TNF-alpha induced by hyperosmolarity, whereas with the administration of SB203580 (10 muM), an inhibitor of the p38 pathway, the inhibiting effect of 17-beta-estradiol disappeared. Estradiol 28-45 interleukin 6 Homo sapiens 107-111 22474579-6 2012 We conclude that a high-carbohydrate meal may evoke a greater postprandial oxidative stress response, whereas both fat and carbohydrate increased IL6. Carbohydrates 123-135 interleukin 6 Homo sapiens 146-149 22474579-7 2012 We speculate that the observed increases in postprandial IL6, without increases in any other markers of inflammation, may indicate a normal IL6 response to enhance glucose uptake, similar to its role postexercise. Glucose 164-171 interleukin 6 Homo sapiens 57-60 22474579-7 2012 We speculate that the observed increases in postprandial IL6, without increases in any other markers of inflammation, may indicate a normal IL6 response to enhance glucose uptake, similar to its role postexercise. Glucose 164-171 interleukin 6 Homo sapiens 140-143 22113278-3 2012 For example, we have demonstrated in vascular endothelial cells that activation of Epac1 is necessary for cAMP-mobilizing agents to trigger the induction of the gene-encoding suppressor of cytokine signaling-3 (SOCS-3), a potent inhibitor of interleukin (IL)-6 signaling. Cyclic AMP 106-110 interleukin 6 Homo sapiens 242-260 22113278-6 2012 We also describe the RNA interference strategies with which we identified a role for Epac1 and SOCS-3 in being responsible for mediating the inhibitory effect of cAMP elevation on IL-6 signaling. Cyclic AMP 162-166 interleukin 6 Homo sapiens 180-184 22605930-10 2012 Interestingly, Travatan and Systane Ultra activated NF-kappaB and elevated the secretion of inflammation markers IL-6 by 3 to eightfold and IL-8 by 1.5 to 3.5 fold, respectively, as analyzed with ELISA. SCHEMBL21048105 28-35 interleukin 6 Homo sapiens 113-117 22605923-6 2012 Pretreatment with 10(-10) M 17-beta-estradiol greatly inhibited the increased expression and production of IL-6, IL-1, and TNF-alpha induced by hyperosmolarity, whereas with the administration of SB203580 (10 muM), an inhibitor of the p38 pathway, the inhibiting effect of 17-beta-estradiol disappeared. Estradiol 273-290 interleukin 6 Homo sapiens 107-111 22605923-8 2012 CONCLUSIONS: 17-beta-estradiol greatly inhibited the expression and production of proinflammatory cytokines IL-6, IL-1, and TNF-alpha, which were stimulated by hyperosmolarity in SV40-immortalized hCECs. Estradiol 13-30 interleukin 6 Homo sapiens 108-112 23087143-10 2012 Meanwhile, EGCG reduced Ang II- and IL-6-stimulated generation of ROS in macrophages. ros 66-69 interleukin 6 Homo sapiens 36-40 23051896-0 2012 Dopamine agonists upregulate IL-6 and IL-8 production in human keratinocytes. Dopamine 0-8 interleukin 6 Homo sapiens 29-33 23051896-8 2012 RESULTS: Dopamine stimulated the production of IL-6 and IL-8 in a concentration-dependent manner. Dopamine 9-17 interleukin 6 Homo sapiens 47-51 23051896-10 2012 The dopamine-induced IL-6 secretion was partially reduced by sulpiride and abrogated by propranolol. Dopamine 4-12 interleukin 6 Homo sapiens 21-25 22302924-0 2012 Intraperitoneal IL-6 signaling in incident patients treated with icodextrin and glucose bicarbonate/lactate-based peritoneal dialysis solutions. Lactic Acid 100-107 interleukin 6 Homo sapiens 16-20 22973975-7 2012 Preincubation of Detroit cells with 200 muM curcumin for 5 to 60 min resulted in complete suppression of the release of tumor necrosis factor-alpha, interleukin (IL)-6, IL-8, monocyte chemoattractant protein 1, granulocyte macrophage-colony stimulating factor, and vascular endothelial growth factor. Curcumin 44-52 interleukin 6 Homo sapiens 149-167 23087143-11 2012 CONCLUSION: EGCG is able to inhibit Ang II- and IL-6-stimulated CRP expression in macrophages to produce an anti-inflammation by interfering with ROS generation. ros 146-149 interleukin 6 Homo sapiens 48-52 23226414-2 2012 Biochemical evidence demonstrates that in primary cortical neurons and SH-SY5Y neuroblastoma cells, IL-6 cytokine family members, OSM and IL-6 plus the soluble IL-6R (IL-6/R), prevent NMDA and glutamate-induced neuronal toxicity. Glutamic Acid 193-202 interleukin 6 Homo sapiens 100-104 23251686-0 2012 Synergistic cooperation between methamphetamine and HIV-1 gsp120 through the P13K/Akt pathway induces IL-6 but not IL-8 expression in astrocytes. Methamphetamine 32-47 interleukin 6 Homo sapiens 102-106 22970235-7 2012 Inhibitory studies using antisense oligonucleotides or neutralizing antibodies indicate that IL-6 induction by TLR4/MD2 complex is important for the activation of endogenous CD14 which later acts in concert or synergy with TLR4/MD2 as a factor resulting in IL-8 gene expression. Oligonucleotides 35-51 interleukin 6 Homo sapiens 93-97 23056374-5 2012 XZH-5 could also inhibit interleukin-6-induced STAT3 phosphorylation in cancer cell lines expressing low phosphorylated STAT3. XZH-5 0-5 interleukin 6 Homo sapiens 25-38 22962620-0 2012 In vivo screening for secreted proteins that modulate glucose handling identifies interleukin-6 family members as potent hypoglycemic agents. Glucose 54-61 interleukin 6 Homo sapiens 82-95 22319624-14 2012 Both fatty acids appeared to abolish H2O2 mediated stimulation of nuclear factor kappaB and IL-6, but not IL-1alpha and IL-8. Fatty Acids 5-16 interleukin 6 Homo sapiens 92-96 22952749-5 2012 The treatment of PCa cells with CDF, a novel Curcumin-derived synthetic analogue previously showed anti-tumor activity in vivo, inhibited the productions of VEGF and IL-6, and down-regulated the expression of Nanog, Oct4, EZH2 mRNAs, as well as miR-21 under hypoxic condition. Curcumin 45-53 interleukin 6 Homo sapiens 32-35 22866178-8 2012 However, vitamin D supplementation markedly enhanced TLR2/1L-induced responses in MDMs e.g. IL-6, IL-12 and IL-23 among Caucasians but not in the Dene participants. Vitamin D 9-18 interleukin 6 Homo sapiens 92-96 22319624-14 2012 Both fatty acids appeared to abolish H2O2 mediated stimulation of nuclear factor kappaB and IL-6, but not IL-1alpha and IL-8. Hydrogen Peroxide 37-41 interleukin 6 Homo sapiens 92-96 22347395-7 2012 MSD, R&D, and ULX, but not LX, detected increases in IL-6 in response to glucose. Glucose 77-84 interleukin 6 Homo sapiens 57-61 20665032-0 2012 Nicotine inhibits tumor necrosis factor-alpha induced IL-6 and IL-8 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis. Nicotine 0-8 interleukin 6 Homo sapiens 54-58 22347395-11 2012 Plasma IL-6 concentrations increase in response to glucose and insulin, consistent with both an early glucose-dependent response (detectable at 1-2 hours) and a late insulin-dependent response (detectable after 2 hours). Glucose 51-58 interleukin 6 Homo sapiens 7-11 22347395-11 2012 Plasma IL-6 concentrations increase in response to glucose and insulin, consistent with both an early glucose-dependent response (detectable at 1-2 hours) and a late insulin-dependent response (detectable after 2 hours). Glucose 102-109 interleukin 6 Homo sapiens 7-11 20665032-4 2012 Nicotine at concentrations of 0.1-10 muM dose reduced the protein and mRNA expression of IL-6 and IL-8 induced by tumor necrosis factor-alpha (TNFalpha). Nicotine 0-8 interleukin 6 Homo sapiens 89-93 21978920-10 2011 Benzoyl-benzoyl-ATP raised intracellular calcium both in VAT and SAT, and induced IL-6, TNFalpha and PAI-1 release in both MS and CTL cells. 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate 0-19 interleukin 6 Homo sapiens 82-86 21424914-9 2011 In the metformin group, body mass index, PPG, HbA1c, IL-6, ICAM-1, and TNF-alpha levels were significantly decreased after 12 weeks compared with the basal levels. Metformin 7-16 interleukin 6 Homo sapiens 53-57 21424914-11 2011 In the rosiglitazone group, FPG, PPG, HbA1c, insulin, HOMA-IR, IL-6, and TNF-alpha levels decreased significantly after 12 weeks compared with the basal levels. Rosiglitazone 7-20 interleukin 6 Homo sapiens 54-67 22440466-4 2011 In addition, the serum concentrations of IGF-I and interleukin-6 were increased by high levels of soy isoflavones (P < 0.05). Isoflavones 102-113 interleukin 6 Homo sapiens 51-64 23091851-8 2012 The CHD and MS patients who carried the Pro allele showed a significant metformin-induced reduction in weight, waist circumference, body mass index, and concentrations of TC, C-peptide, and cytokines, such IL-1beta, IL-6, IL-8, and TNF-alpha. Metformin 72-81 interleukin 6 Homo sapiens 216-220 22092186-3 2011 When incubated with oligonucleotides containing CpGs, immune cells are stimulated through TLR9 to produce and secrete cytokine mediators such as interleukin-6 (IL-6) and interleukin-12p70 (IL-12p70), a process associated with the initiation of an immune response. Oligonucleotides 20-36 interleukin 6 Homo sapiens 145-158 22092186-3 2011 When incubated with oligonucleotides containing CpGs, immune cells are stimulated through TLR9 to produce and secrete cytokine mediators such as interleukin-6 (IL-6) and interleukin-12p70 (IL-12p70), a process associated with the initiation of an immune response. Oligonucleotides 20-36 interleukin 6 Homo sapiens 160-164 21723567-9 2011 Moreover, activated Vitamin D enhanced the development of IL-10 producing cells, and reduced the number of IL-6 and IL-17 secreting cells. Vitamin D 20-29 interleukin 6 Homo sapiens 107-111 21801267-7 2011 Treatment with metformin significantly reduced IL-6, especially in PCOS patients with IRS-2 homozygous Asp variant. Metformin 15-24 interleukin 6 Homo sapiens 47-51 21956421-12 2011 The induction of IL-6 can be blocked by dexamethasone, a chemical inhibitor of Akt/Pkb, and by knocking down Akt with a specific small interfering RNA. Dexamethasone 40-53 interleukin 6 Homo sapiens 17-21 21110076-5 2011 Berberine effectively inhibited IL-6 and TNF-alpha production in a concentration-dependent manner, demonstrating its anti-inflammatory activity in hepatocytes. Berberine 0-9 interleukin 6 Homo sapiens 32-36 21274653-5 2011 The mechanisms by which calcium fructoborate exerts its beneficial anti-inflammatory effects are not entirely clear, but some of its molecular biological in vitro activities are understood: inhibition of the superoxide within the cell; inhibition of the interleukin-1beta, interleukin-6, and nitric oxide release in the culture media; and increase of the tumor necrosis factor-alpha production. Calcium 24-31 interleukin 6 Homo sapiens 273-286 21234673-9 2011 These functional alterations were driven by elevated cAMP, as direct activation of adenylate cyclase by forskolin elicited similar alterations in VEGF and IL-6 production. Cyclic AMP 53-57 interleukin 6 Homo sapiens 155-159 21234673-13 2011 Furthermore, in the same cells, beta-AR activate a cAMP-dependent, PKA-independent pathway to increase IL-6 production. Cyclic AMP 51-55 interleukin 6 Homo sapiens 103-107 21995333-0 2011 Mast cell-derived TNF-alpha and histamine modify IL-6 and IL-8 expression and release from cutaneous tumor cells. Histamine 32-41 interleukin 6 Homo sapiens 49-53 21964048-5 2011 The treatment of EPCs with TLR3 agonist Poly I:C up-regulated the expression of cytokines IL-1beta, IL-6, IL-8, TNF-alpha, IFN-alpha, and IFN-beta, indicating that EPCs expressed functional TLR3. Poly I 40-46 interleukin 6 Homo sapiens 100-104 21964048-5 2011 The treatment of EPCs with TLR3 agonist Poly I:C up-regulated the expression of cytokines IL-1beta, IL-6, IL-8, TNF-alpha, IFN-alpha, and IFN-beta, indicating that EPCs expressed functional TLR3. Carbon 19-20 interleukin 6 Homo sapiens 100-104 23268452-8 2011 Dexamethasone was found to decrease IL-6 production, while salbutamol increased it. Dexamethasone 0-13 interleukin 6 Homo sapiens 36-40 20828737-9 2011 Pretreatment with rapamycin, a specific inhibitor of mTOR, resulted in a significant decrease of IL-10 and IL-6 translation and expression but did not affect the LPS-induced TNFalpha production. Sirolimus 18-27 interleukin 6 Homo sapiens 107-111 21788952-2 2011 OBJECTIVES: Previous studies indicated that at least 2-h leg exercise at more than 60% maximum oxygen consumption (VO(2)max) increased plasma interleukin (IL)-6 in able-bodied (AB) subjects. Oxygen 95-101 interleukin 6 Homo sapiens 142-160 21910986-5 2011 Pretreatment with the HO-1 inhibitor, tin protoporphyrin (SnPP), attenuated the inhibitory activities of LA on LPS-induced inflammatory NO, PGE(2), IL-1beta, TNF-alpha, IL-6 and IL-12 production. S-Nitroso-N-propionyl-D,L-penicillamine 58-62 interleukin 6 Homo sapiens 169-173 22085404-10 2011 Disease severity characterized by elevated creatinine and low platelet counts was correlated with high pro-inflammatory IL-6 and TNF-alpha but low immunosuppressive TGF-beta1 levels and vice versa . Creatinine 43-53 interleukin 6 Homo sapiens 120-124 21857489-8 2011 The effect of starting ART on changes in HDL-P and ApoA1 was greater for those with higher versus lower baseline levels of IL-6 (P = 0.001 and 0.08, respectively, for interaction) or hsCRP (P = 0.01 and 0.04, respectively, for interaction). art 23-26 interleukin 6 Homo sapiens 123-127 22085740-4 2011 Ringer"s lactate solution (RLS) has been shown to increase serum TNF-alpha and IL-6 in patients and experimental animals; in addition, RLS also provides lactate, which can be used as an alternative metabolic fuel to meet the higher energy demand by liver regeneration. Lactic Acid 9-16 interleukin 6 Homo sapiens 79-83 21511816-7 2011 Adjusted for traditional risk factors, hsCRP and IL-6 were independently associated with death-censored graft loss, the composite end points graft loss or death and doubling of serum creatinine, graft loss or death. Creatinine 183-193 interleukin 6 Homo sapiens 49-53 21940629-5 2011 The glucocorticoid-dependent induction of NLRP3 sensitizes the cells to extracellular ATP and significantly enhances the ATP-mediated release of proinflammatory molecules, including mature IL-1beta, TNF-alpha, and IL-6. Adenosine Triphosphate 121-124 interleukin 6 Homo sapiens 214-218 21641579-9 2011 Finally, we demonstrated that either the conditioned medium collected from pressurised dental pulp cells or addition of UDP, a selective agonist of P2Y6, up-regulated IL-6 expression in HDPCs. Uridine Diphosphate 120-123 interleukin 6 Homo sapiens 167-171 21859832-8 2011 Several single-nucleotide polymorphisms interacted significant with both NF-kappaB1 and IL6 and with aspirin/non-steroidal anti-inflammatory drugs and cigarette smoking. Aspirin 101-108 interleukin 6 Homo sapiens 88-91 21357632-9 2011 Compared to no atorvastatin group, the levels of MDA, ROS and the expression of IL-6, TNF-alpha, ET-1 and P-selectin decreased in HUVECs in adding atorvastatin group, but cell viability, NO and SOD increased, which indicated that atorvastatin attenuated fine particle-induced inflammatory response, oxidative stress and endothelial damage. Atorvastatin 147-159 interleukin 6 Homo sapiens 80-84 21357632-9 2011 Compared to no atorvastatin group, the levels of MDA, ROS and the expression of IL-6, TNF-alpha, ET-1 and P-selectin decreased in HUVECs in adding atorvastatin group, but cell viability, NO and SOD increased, which indicated that atorvastatin attenuated fine particle-induced inflammatory response, oxidative stress and endothelial damage. Atorvastatin 147-159 interleukin 6 Homo sapiens 80-84 21751240-6 2011 Given the increased risk of ONJ with obesity and importance of macrophages in wound healing, we hypothesized that amino-bisphosphonates could contribute to the pathogenesis of ONJ by regulating macrophage responses to cytokines such as leptin and IL-6. amino-bisphosphonates 114-135 interleukin 6 Homo sapiens 247-251 21357632-8 2011 Meanwhile, at the same exposure dose, water-soluble fraction caused more significant increase of MDA, IL-6, TNF-alpha and P-selectin and decrease of cell viability and NO when compared to organic extracts. Water 38-43 interleukin 6 Homo sapiens 102-106 22086794-4 2011 RESULTS: In the analysis with leptin as a dependent variable, the IL-6 and glucose levels remained in the model (F = 6.2; P<0.05), with an increase of 5.8 (CI 95%:2.7-7.6) ng/ml with each 1 pg/ml of IL-6 and of 5.2 (CI95%:2.5-5.8) ng/ml with each 1 mg/dl of glucose. Glucose 75-82 interleukin 6 Homo sapiens 202-206 22086794-4 2011 RESULTS: In the analysis with leptin as a dependent variable, the IL-6 and glucose levels remained in the model (F = 6.2; P<0.05), with an increase of 5.8 (CI 95%:2.7-7.6) ng/ml with each 1 pg/ml of IL-6 and of 5.2 (CI95%:2.5-5.8) ng/ml with each 1 mg/dl of glucose. Glucose 261-268 interleukin 6 Homo sapiens 66-70 22086794-6 2011 In the third multivariate analysis with IL-6 as a dependent variable, the glucose level remained in the model (F = 10.1; P<0.01), with an increase of 0.09 (CI95%:0.06-0.12) pg/ml with each 1 mg/dl of glucose. Glucose 74-81 interleukin 6 Homo sapiens 40-44 21777617-5 2011 Therapy with vitamin D in animal models of sepsis improves blood coagulation parameters in disseminated intravascular coagulation and modulates levels of systemic inflammatory cytokines including TNF-alpha and IL-6. Vitamin D 13-22 interleukin 6 Homo sapiens 210-214 21796149-4 2011 Well-differentiated NHEKs produced elevated IL-8 levels, whereas ATP, a danger signal, significantly increased IL-8 and IL-6 production, and the pathogen-associated compound, poly(I:C), augmented IL-1alpha production by beta-glucan-stimulated NHEKs. Adenosine Triphosphate 65-68 interleukin 6 Homo sapiens 120-124 21700295-8 2011 The Ala allele of Asp358Ala was significantly associated with higher levels of both IL-6 and sIL-6R. Alanine 4-7 interleukin 6 Homo sapiens 84-88 21842098-5 2011 Cadmium also induced the release of TNF-alpha and IL-6 in THP-1 monocytic cells, which may indicate some potential to induce deleterious effects through this pathway. Cadmium 0-7 interleukin 6 Homo sapiens 50-54 21911244-0 2011 Effects of the interleukin-6 (IL-6) polymorphism on toxic metal and trace element levels in placental tissues. Metals 58-63 interleukin 6 Homo sapiens 30-34 21911244-8 2011 We investigated the association between the IL-6 -174 G/C polymorphism and trace element/toxic metal levels in placental tissues. Metals 95-100 interleukin 6 Homo sapiens 44-48 22088587-13 2011 CONCLUSION: Flavonoids of puerarin can restrain the increase of IL-6 after acute ischemic stroke, and depress the LDH raised by reperfusion after cerebral ischemia. puerarin 26-34 interleukin 6 Homo sapiens 64-68 22103940-5 2011 In addition, skin irritation induced by an application of sodium dodecyl sulphate resulted in significantly higher lactate dehydrogenase leakage, and interleukin (IL)-6 and IL-8 levels, than in the control model. Sodium Dodecyl Sulfate 58-81 interleukin 6 Homo sapiens 150-168 22292182-46 2011 CONCLUSION: Hyperoxia induced intracellular ROS production can up-regulate TLR2/4 expression in A549 cells, leading to the release pro-inflammatory cytokines IL-6 and IL-8 from these cells. Reactive Oxygen Species 44-47 interleukin 6 Homo sapiens 158-162 21990194-0 2011 Synthesis of silver nanoparticle-hollow titanium phosphate sphere hybrid as a label for ultrasensitive electrochemical detection of human interleukin-6. titanium phosphate 40-58 interleukin 6 Homo sapiens 138-151 21990194-1 2011 A silver nanoparticle-hollow titanium phosphate sphere (AgNP-TiP) hybrid is successfully synthesized and used as a label for electrochemical detection of human interleukin-6 (IL-6). titanium phosphate 29-47 interleukin 6 Homo sapiens 160-173 21990194-1 2011 A silver nanoparticle-hollow titanium phosphate sphere (AgNP-TiP) hybrid is successfully synthesized and used as a label for electrochemical detection of human interleukin-6 (IL-6). titanium phosphate 29-47 interleukin 6 Homo sapiens 175-179 21771721-5 2011 12-O-tetradecanoylphorbol 13-acetate-induced differentiation of human U937 monocytes increased the expression and secretion of inflammatory cytokines such as tumor necrosis factor alpha, interleukin (IL)-6 and IL-8. Tetradecanoylphorbol Acetate 0-36 interleukin 6 Homo sapiens 187-205 21734258-9 2011 However, RLN activation of RXFP1 induced a dose-dependent cAMP response, which when mimicked by forskolin also caused significantly increased (P < 0.05) secretion of IL6. Cyclic AMP 58-62 interleukin 6 Homo sapiens 169-172 21724580-6 2011 In the vitamin D(3) supplementation group, TNF-alpha decreased 13%, IL-6 32%, IL-1beta 50%, and IL-8 15%; in the calcium supplementation group, IL-6 decreased 37%, IL-8 11%, and IL-1beta 27%. Calcium 113-120 interleukin 6 Homo sapiens 144-148 22031502-10 2011 Only interleukin-6 appeared to be exclusively dependent on long-term testosterone application. Testosterone 69-81 interleukin 6 Homo sapiens 5-18 21930594-0 2011 Aryl hydrocarbon receptor negatively regulates LPS-induced IL-6 production through suppression of histamine production in macrophages. Histamine 98-107 interleukin 6 Homo sapiens 59-63 21501171-8 2011 Only IL-6 gingival crevicular fluid levels were significantly different between ovulation and progesterone peak (p < 0.05). Progesterone 94-106 interleukin 6 Homo sapiens 5-9 21585521-8 2011 Melatonin, but not atorvastatin, reduced free radical generation, lipid peroxidation, and interleukin-6 levels induced by LPS. Melatonin 0-9 interleukin 6 Homo sapiens 90-103 21177727-6 2011 The mutant genotype (CC+GC) of IL-6 gene was found to be associated significantly with high triglyceride (p = 0.025) and resistin level (p < 0.001), when compared with respective wild genotype (GG) in obese women. Triglycerides 92-104 interleukin 6 Homo sapiens 31-35 21930594-6 2011 Collectively, these results demonstrate that Ahr negatively regulates IL-6 production via H1R signaling through the suppression of histamine production in macrophages following LPS stimulation. Histamine 131-140 interleukin 6 Homo sapiens 70-74 21930594-3 2011 Here, we show that Ahr also negatively regulates production of the pro-inflammatory cytokine IL-6 by suppressing histamine production in macrophages stimulated by LPS. Histamine 113-122 interleukin 6 Homo sapiens 93-97 21836082-7 2011 Patients with CDM had higher serum levels of interleukin-10, tumor necrosis factor-alpha, and glutamate and lower serum levels of neuron-specific enolase, interleukin-6, and active matrix metalloproteinase-9 (all P<0.0001). Chlorphenamidine 14-17 interleukin 6 Homo sapiens 155-168 21372265-7 2011 The group with iron overload had lower body mass index (17 versus 19; P = 0.01), total cholesterol (132 versus 165 mg/dL; P = 0.03) and hemoglobin (8.5 versus 10.6 g/dL; P = 0.003) but higher interleukin (IL)-6 levels (4.8 versus 3.6 ng/L; P = 0.04) and hypertension diagnosis (79 versus 48%; P < 0.001) than those without iron overload. Iron 15-19 interleukin 6 Homo sapiens 192-210 21934447-6 2011 Poly (inosinic acid:cytidylic acid) by itself stimulated the release of IL-6 (305 pg/mL) and enhanced IL-8 production (2.8 ng/mL). Poly I 0-19 interleukin 6 Homo sapiens 72-76 21923231-1 2011 IL-6 is believed to mediate the elevation in plasma TG and VLDL lipids in patients with sepsis. Thioguanine 52-54 interleukin 6 Homo sapiens 0-4 21587103-10 2011 RESULTS: In vitro, resveratrol exhibited an anti-inflammatory and anticatabolic effect on the messenger RNA and protein level for IL-6, IL-8, MMP1, MMP3 and MMP13. Resveratrol 19-30 interleukin 6 Homo sapiens 130-134 21795409-2 2011 EXPERIMENTAL DESIGN: We combined preclinical and in silico experiments with a phase 2 clinical trial of the anti-IL-6 antibody siltuximab in patients with platinum-resistant ovarian cancer. Platinum 155-163 interleukin 6 Homo sapiens 113-117 21658381-5 2011 Based on these nine top sequences in the combination group excluding four overlapping pathways (MAPK-ERK, Kitlg, Icam1-Ap1, and prolactin), the jasminoidin group had four (PRLR-STAT1, AcvR2-AcvR1B, ACVR1/2A-SMAD1, GHR-NF-kappaB) contributing pathways, and the ursodeoxycholic acid group had one (IL-6) contributing pathway. geniposide 144-155 interleukin 6 Homo sapiens 296-300 21726543-3 2011 Further, mitogen and antigen-stimulated cytokine (IL-2, IL-4, IL-6 and IFN-gamma) secretion by T cells was also abrogated by curcumin and DiMC. Curcumin 125-133 interleukin 6 Homo sapiens 62-66 21771795-9 2011 Claudin-2 promoter activity is increased by IL-6 in a MEK/ERK and PI3K-dependent manner, and deletion of Cdx binding sites in the promoter sequence results in a loss of IL-6-induced promoter activity. Cefadroxil 105-108 interleukin 6 Homo sapiens 169-173 21664353-11 2011 A further proof was achieved by DEX inhibition for IL1-beta-stimulated IL-6 and COX-2 gene expression. Dexamethasone 32-35 interleukin 6 Homo sapiens 71-75 21757719-0 2011 Interleukin-6 protects human macrophages from cellular cholesterol accumulation and attenuates the proinflammatory response. Cholesterol 55-66 interleukin 6 Homo sapiens 0-13 21757719-6 2011 Interestingly, IL-6 markedly induced ABCA1 expression and enhanced ABCA1-mediated cholesterol efflux from human macrophages to apoAI. Cholesterol 82-93 interleukin 6 Homo sapiens 15-19 21757719-7 2011 Stimulation of ABCA1-mediated cholesterol efflux by IL-6 was, however, abolished by selective inhibition of the Jak-2/Stat3 signaling pathway. Cholesterol 30-41 interleukin 6 Homo sapiens 52-56 21757719-9 2011 Consistent with these findings, IL-6 enhanced the capacity of human macrophages to phagocytose apoptotic cells; moreover, we observed that IL-6 stimulates the ABCA1-mediated efflux of cholesterol derived from the ingestion of free cholesterol-loaded apoptotic macrophages. Cholesterol 184-195 interleukin 6 Homo sapiens 32-36 21757746-8 2011 Using a luciferase reporter, we demonstrated that LPS treatment induced IL6 promoter-driven luciferase which was suppressed using MEK/ERK pharmacologic inhibitors (PD98059 or U0126) and RNAi-induced depletion of N-Ras. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 164-171 interleukin 6 Homo sapiens 72-75 21757719-9 2011 Consistent with these findings, IL-6 enhanced the capacity of human macrophages to phagocytose apoptotic cells; moreover, we observed that IL-6 stimulates the ABCA1-mediated efflux of cholesterol derived from the ingestion of free cholesterol-loaded apoptotic macrophages. Cholesterol 184-195 interleukin 6 Homo sapiens 139-143 21811961-8 2011 (2) Arterial interleukin-6 (p=0.002) and subcutaneous venous interleukin-6 (p=0.014) were negatively associated with forearm glucose uptake in obese. Glucose 125-132 interleukin 6 Homo sapiens 13-26 21757719-9 2011 Consistent with these findings, IL-6 enhanced the capacity of human macrophages to phagocytose apoptotic cells; moreover, we observed that IL-6 stimulates the ABCA1-mediated efflux of cholesterol derived from the ingestion of free cholesterol-loaded apoptotic macrophages. Cholesterol 231-242 interleukin 6 Homo sapiens 32-36 21757719-9 2011 Consistent with these findings, IL-6 enhanced the capacity of human macrophages to phagocytose apoptotic cells; moreover, we observed that IL-6 stimulates the ABCA1-mediated efflux of cholesterol derived from the ingestion of free cholesterol-loaded apoptotic macrophages. Cholesterol 231-242 interleukin 6 Homo sapiens 139-143 21757719-11 2011 Taken together, our results indicate that IL-6 favors the elimination of excess cholesterol in human macrophages and phagocytes by stimulation of ABCA1-mediated cellular free cholesterol efflux and attenuates the macrophage proinflammatory phenotype. Cholesterol 80-91 interleukin 6 Homo sapiens 42-46 21757719-11 2011 Taken together, our results indicate that IL-6 favors the elimination of excess cholesterol in human macrophages and phagocytes by stimulation of ABCA1-mediated cellular free cholesterol efflux and attenuates the macrophage proinflammatory phenotype. Cholesterol 175-186 interleukin 6 Homo sapiens 42-46 21757719-12 2011 Thus, high amounts of IL-6 secreted by lipid laden human macrophages may constitute a protective response from macrophages to prevent accumulation of cytotoxic-free cholesterol. Cholesterol 165-176 interleukin 6 Homo sapiens 22-26 21784820-11 2011 CONCLUSIONS: Administration of the noncalcium phosphate binder sevelamer to maintenance HD patients is associated with a significant decrease in hs-CRP, IL-6, serum endotoxin levels and sCD14 concentrations. Phosphates 46-55 interleukin 6 Homo sapiens 153-157 21811961-8 2011 (2) Arterial interleukin-6 (p=0.002) and subcutaneous venous interleukin-6 (p=0.014) were negatively associated with forearm glucose uptake in obese. Glucose 125-132 interleukin 6 Homo sapiens 61-74 21679760-6 2011 RESULTS: Sinomenine was found to significantly inhibit TNF-alpha induced cell surface expression of vascular cell adhesion molecule (VCAM)-1 and release of inflammatory cytokine and chemokine IL-6, CCL2 and CXCL8 from both normal and RA-FLS (all p<0.05). sinomenine 9-19 interleukin 6 Homo sapiens 192-196 21142820-5 2011 Apigenin significantly inhibits the inductive effect of phorbol 12-myristate 13-acetate (PMA) plus A23187 on the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-8, IL-6, and granulocyte-macrophage colony-stimulating factor (GM-CSF). Tetradecanoylphorbol Acetate 56-87 interleukin 6 Homo sapiens 213-217 21679760-7 2011 Moreover, the suppression of sinomenine on TNF-alpha induced VCAM-1 expression and IL-6 release of RA-FLS was significantly higher than that of normal FLS (p<0.05). sinomenine 29-39 interleukin 6 Homo sapiens 83-87 21873959-4 2011 Pro-inflammatory cytokines, such as TNF-alpha, IL-1 and IL-6, stimulate central serotonin (5-HT) neurotransmission and are over-expressed in depression, which has been linked with hypothalamic-pituitary-adrenal axis (HPA) hyperactivity. Serotonin 80-89 interleukin 6 Homo sapiens 56-60 21885526-0 2011 Interleukin 6 blockade as steroid-sparing treatment for 2 patients with giant cell arteritis. Steroids 26-33 interleukin 6 Homo sapiens 0-13 22012292-4 2011 Prevalence ratios for glucose intolerance and diabetes across allelic variants of IL-6 and TNF-alpha did not associate IL-6 with unbalanced glucose levels, despite adjustment for BMI, age, and conicity index. Glucose 22-29 interleukin 6 Homo sapiens 82-86 21295946-6 2011 Curcumin decreased secretion of IL-6 (P = 0.015) and IL-1 beta (P = 0.016). Curcumin 0-8 interleukin 6 Homo sapiens 32-36 21904657-4 2011 Our novel compound CDF (a synthetic analogue of curcumin), is one such multi-targeted agent with proven anti-cancer activity in vitro and in vivo. Curcumin 48-56 interleukin 6 Homo sapiens 19-22 21555507-6 2011 IL-6 suppressed induction of CYP1A2 enzyme activity by omeprazole and CYP3A4 enzyme activity by rifampicin but only at supraphysiological concentrations of IL-6. Omeprazole 55-65 interleukin 6 Homo sapiens 0-4 21229380-15 2011 In healthy controls, serum IL-6 was undetectable at baseline and after IV iron administration. Iron 74-78 interleukin 6 Homo sapiens 27-31 21768398-8 2011 Progesterone enhanced activation of STAT5 in response to IL-2, whereas it decreased STAT3 activation in response to IL-6, which is in line with the selective activity of progesterone in generation of Tregs versus Th17 cells. Progesterone 0-12 interleukin 6 Homo sapiens 116-120 21768398-8 2011 Progesterone enhanced activation of STAT5 in response to IL-2, whereas it decreased STAT3 activation in response to IL-6, which is in line with the selective activity of progesterone in generation of Tregs versus Th17 cells. Progesterone 170-182 interleukin 6 Homo sapiens 116-120 21651918-13 2011 Moreover, reduction in the levels of IL-6, IL-1Ra, MCP-1/CCL2 and IL-8/CXCL8 was observed in the presence of APE1 Glu allele in BM patients. Glutamic Acid 114-117 interleukin 6 Homo sapiens 37-41 21732177-6 2011 Further, IL-6 treatment led to decreased mitochondrial membrane potential, decreased cellular ATP production, and increased intracellular ROS levels. Adenosine Triphosphate 94-97 interleukin 6 Homo sapiens 9-13 21732177-6 2011 Further, IL-6 treatment led to decreased mitochondrial membrane potential, decreased cellular ATP production, and increased intracellular ROS levels. ros 138-141 interleukin 6 Homo sapiens 9-13 21744422-8 2011 RESULTS: ISEMFs of CD patients exhibited an increased oxidative state due to a decrease in the GSH/GSSG ratio, which is related to an increase in basal IL-6 production or is stimulated by tumor necrosis factor alpha (TNFalpha) or bacterial products. Glutathione 95-98 interleukin 6 Homo sapiens 152-156 21744422-11 2011 CONCLUSIONS: This study shows for the first time in ISEMFs of CD patients an increased production of IL-6 synthesis related to the decrease in the GSH/GSSH ratio, suggesting redox regulation with the involvement of specific kinase activation. Glutathione 147-150 interleukin 6 Homo sapiens 101-105 21744422-11 2011 CONCLUSIONS: This study shows for the first time in ISEMFs of CD patients an increased production of IL-6 synthesis related to the decrease in the GSH/GSSH ratio, suggesting redox regulation with the involvement of specific kinase activation. gssh 151-155 interleukin 6 Homo sapiens 101-105 21781004-6 2011 The component of intracellular Ca2+ overload after EGTA treatment was prevented by IL-6 chronic exposure. Egtazic Acid 51-55 interleukin 6 Homo sapiens 83-87 21825929-13 2011 Enzyme-linked immunosorbent assay demonstrated that IL-6 concentration increased over time for all groups (p < 0.05), but less so at 2 hours in the AA group compared with CA and HCl. Hydrochloric Acid 181-184 interleukin 6 Homo sapiens 52-56 21529753-10 2011 CONCLUSION: Repeated-course antenatal steroids may reduce the increased risk of neurodevelopmental delay at age 2 years associated with IL-6 -174 GG genotype. Steroids 38-46 interleukin 6 Homo sapiens 136-140 21770806-7 2011 The concentration of IL-6, 8 was also enhanced by low-concentration hydrocortisone and inhibited by high-concentration hydrocortisone. Hydrocortisone 68-82 interleukin 6 Homo sapiens 21-25 21770806-7 2011 The concentration of IL-6, 8 was also enhanced by low-concentration hydrocortisone and inhibited by high-concentration hydrocortisone. Hydrocortisone 119-133 interleukin 6 Homo sapiens 21-25 21936374-4 2011 The results showed that the 0.9 microm titanium particles promoted osteoblasts producing bone resorption cytokines (IL-6, ODF), and simultaneously secreted bone absorption restraining factor (IL-10) quickly and transitorily. Titanium 39-47 interleukin 6 Homo sapiens 116-120 21670312-10 2011 Finally, there is a strong synergy between calcium depletion in the ER and sterile IL-6, as well as LPS-dependent IL-1beta, IL-12, IL-23, and TNF-alpha innate responses, findings that have implications for understanding inflammatory diseases that originate in the ER. Calcium 43-50 interleukin 6 Homo sapiens 83-87 21555360-7 2011 Finally, we have shown that lipoxin A(4) can suppress phorbol myristate acetate-induced expression of the inflammatory cytokines interleukin 6 and 8 in human endometrium and decidua tissue. Tetradecanoylphorbol Acetate 54-79 interleukin 6 Homo sapiens 129-148 21774820-9 2011 Induction of IL-6 mRNA by LPS was reduced by metformin (p < 0.01), while the LPS-induced mRNA expression of the naturally occurring anti-inflammatory cytokine interleukin 1 receptor antagonist was increased (p < 0.01). Metformin 45-54 interleukin 6 Homo sapiens 13-17 21690253-7 2011 This was associated with phosphorylation of tyrosine 705, a residue required for IL-6-induced STAT3 activation. Tyrosine 44-52 interleukin 6 Homo sapiens 81-85 22088250-1 2011 OBJECTIVE: To investigate the effects of atorvastatin on C-reactive protein (CRP) induced Toll-Like receptor 4 (TLR4)expression on CD14+ monocyte, and the production of proinflammatory cytokines tumor necrosis factor alpha (TNFalpha), interleukin-6 (IL-6), matrix metalloproteinases-9 (MMP-9), and to study the anti-inflammatory mechanisms of statins. Atorvastatin 41-53 interleukin 6 Homo sapiens 235-248 21435102-0 2011 Novel small molecule, XZH-5, inhibits constitutive and interleukin-6-induced STAT3 phosphorylation in human rhabdomyosarcoma cells. XZH-5 22-27 interleukin 6 Homo sapiens 55-68 21424515-7 2011 RESULTS: NAC inhibits the inflammatory cytokines TNFalpha, IL-1beta and IL-6 in LPS-activated macrophages under mild oxidative conditions. Acetylcysteine 9-12 interleukin 6 Homo sapiens 72-76 21345936-6 2011 Polysulphated cyclodextrins MA-CDPS, HP-CDPS, CE-CDPS and CDPS at 5 microg/ml concentrations, on the other hand, significantly induced aggrecan production and repressed IL-6 release by the chondrocytes in culture. Cyclodextrins 14-27 interleukin 6 Homo sapiens 169-173 21265971-5 2011 By multinomial logistic analysis, IL-6 was significantly related to DWMH score, independent of age and systolic blood pressure. dwmh 68-72 interleukin 6 Homo sapiens 34-38 21708999-9 2011 IL-6 antisense oligonucleotide treatment resulted in a significant reduction of IL-6 protein expression compared to the sense control. Oligonucleotides 15-30 interleukin 6 Homo sapiens 0-4 21708999-9 2011 IL-6 antisense oligonucleotide treatment resulted in a significant reduction of IL-6 protein expression compared to the sense control. Oligonucleotides 15-30 interleukin 6 Homo sapiens 80-84 21708999-10 2011 The antisense oligonucleotides targeting IL-6 mRNA, also, inhibited cell growth and IL-6 production as well as VEGF expression. Oligonucleotides 14-30 interleukin 6 Homo sapiens 41-45 21708999-10 2011 The antisense oligonucleotides targeting IL-6 mRNA, also, inhibited cell growth and IL-6 production as well as VEGF expression. Oligonucleotides 14-30 interleukin 6 Homo sapiens 84-88 21708999-12 2011 Taken together, these findings indicate that endogenous IL-6 plays an important role in the growth of HNSCC and exerts its action by an autocrine growth mechanism, and that therapeutic trials with antisense oligonucleotides targeted to IL-6 mRNA may have some value for the treatment of HNSCC due to a decrease of neovascularization. Oligonucleotides 207-223 interleukin 6 Homo sapiens 56-60 21708999-12 2011 Taken together, these findings indicate that endogenous IL-6 plays an important role in the growth of HNSCC and exerts its action by an autocrine growth mechanism, and that therapeutic trials with antisense oligonucleotides targeted to IL-6 mRNA may have some value for the treatment of HNSCC due to a decrease of neovascularization. Oligonucleotides 207-223 interleukin 6 Homo sapiens 236-240 20817560-13 2011 IL-6 may be an important intermediary between vitamin D deficiency and albuminuria, or vitamin D deficiency may contribute to inflammation and subsequent albuminuria. Vitamin D 46-55 interleukin 6 Homo sapiens 0-4 21886908-6 2011 In addition, plasma glucose level showed significant positive correlation with hydrogen peroxide, malondialdehyde, tumor necrosis factor-alpha and interleukin-6. Glucose 20-27 interleukin 6 Homo sapiens 147-160 22088250-1 2011 OBJECTIVE: To investigate the effects of atorvastatin on C-reactive protein (CRP) induced Toll-Like receptor 4 (TLR4)expression on CD14+ monocyte, and the production of proinflammatory cytokines tumor necrosis factor alpha (TNFalpha), interleukin-6 (IL-6), matrix metalloproteinases-9 (MMP-9), and to study the anti-inflammatory mechanisms of statins. Atorvastatin 41-53 interleukin 6 Homo sapiens 250-254 22088250-8 2011 (4) Level of TNFalpha, IL-6 and MMP-9 in supernatants was significantly reduced by atorvastatin (2.5 micromol/L) compared with control group (P < 0.01). Atorvastatin 83-95 interleukin 6 Homo sapiens 23-27 22088250-9 2011 When monocyte incubated with CRP 50 microg/ml and atorvastatin 10.0 micromol/L, the level of TNFalpha, IL-6, MMP-9 decreased to (25.8 +/- 2.5) microg/ml, (128.2 +/- 14.7) pg/ml, (65.2 +/- 12.3) ng/ml, respectively. Atorvastatin 50-62 interleukin 6 Homo sapiens 103-107 21474440-8 2011 Ser-226 is shown to be required for the ligand-independent GR-mediated repression of IL-6 in response to TNFalpha. Serine 0-3 interleukin 6 Homo sapiens 85-89 21555530-5 2011 NO antagonized IL-6 to block TGF-beta-directed Th17 differentiation, and together with IL-6, NO suppressed Treg development induced by TGF-beta and retinoic acid. Tretinoin 148-161 interleukin 6 Homo sapiens 87-91 21143185-4 2011 There is recent evidence that the NF-kappaB-dependent gene expression of interleukin 8, interleukin 6, cyclooxygenase-2, tumor necrosis factor and interleukin 33 in directly irradiated cells produced the cytokines and prostaglandin E2 with autocrine/paracrine functions, which further activated signaling pathways and induced NF-kappaB-dependent gene expression in bystander cells. Dinoprostone 218-234 interleukin 6 Homo sapiens 88-101 21474332-0 2011 The vanilloid capsaicin induces IL-6 secretion in prostate PC-3 cancer cells. Capsaicin 4-13 interleukin 6 Homo sapiens 32-36 21070572-10 2011 CONCLUSION: Anaemia depends on serum IL-6, which is a strong inductor of CRP and regulator of the iron-transport. Iron 100-104 interleukin 6 Homo sapiens 39-43 21474332-5 2011 Furthermore, incubation of PC-3 cells with an anti-TNF-alpha antibody blocked the capsaicin-induced IL-6 secretion. Capsaicin 82-91 interleukin 6 Homo sapiens 100-104 21414799-0 2011 Nitric oxide affects IL-6 expression in human peripheral blood mononuclear cells involving cGMP-dependent modulation of NF-kappaB activity. Nitric Oxide 0-12 interleukin 6 Homo sapiens 21-25 21414799-0 2011 Nitric oxide affects IL-6 expression in human peripheral blood mononuclear cells involving cGMP-dependent modulation of NF-kappaB activity. Cyclic GMP 91-95 interleukin 6 Homo sapiens 21-25 21414799-3 2011 Using sodium nitroprusside (SNP) and S-nitrosoglutathione (GSNO) as NO-donating compounds, we observed that both mRNA and protein levels of IL-6 increased at lower (<=10muM) and decreased at higher (>100muM) concentrations of NO donors. S-Nitrosoglutathione 37-57 interleukin 6 Homo sapiens 140-144 21414799-3 2011 Using sodium nitroprusside (SNP) and S-nitrosoglutathione (GSNO) as NO-donating compounds, we observed that both mRNA and protein levels of IL-6 increased at lower (<=10muM) and decreased at higher (>100muM) concentrations of NO donors. S-Nitrosoglutathione 59-63 interleukin 6 Homo sapiens 140-144 21474332-0 2011 The vanilloid capsaicin induces IL-6 secretion in prostate PC-3 cancer cells. Capsaicin 14-23 interleukin 6 Homo sapiens 32-36 21474332-3 2011 Capsaicin-treated PC-3 cells increased the synthesis and secretion of IL-6 which was abrogated by the transient receptor potential vanilloid receptor subtype 1 (TRPV1) antagonist capsazepine, as well as by inhibitors of PKC-alpha, phosphoinositol-3 phosphate kinase (PI-3K), Akt and extracellular signal-regulated protein kinase (ERK). Capsaicin 0-9 interleukin 6 Homo sapiens 70-74 21474332-6 2011 These results raise the possibility that capsaicin-mediated IL-6 increase in prostate cancer PC-3 cells is regulated at least in part by TNF-alpha secretion and signaling pathway involving Akt, ERK and PKC-alpha activation. Capsaicin 41-50 interleukin 6 Homo sapiens 60-64 21069571-9 2011 Dexamethasone attenuated LPS-induced IL-1 beta (IC(50) = 70 nM), IL-6 (IC(50) = 58 nM) and TNF-alpha (IC(50) = 44 nM) release, whereas celecoxib, a specific COX-2 inhibitor showed marked reduction in LPS-induced PGE(2) (IC(50) = 23 nM) production. Dexamethasone 0-13 interleukin 6 Homo sapiens 65-69 20945380-9 2011 Treatment of microglia with AP-1 inhibitors (Tanshinone IIA and curcumin) effectively reduced PGN-induced IL-6 expression. tanshinone 45-59 interleukin 6 Homo sapiens 106-110 20626232-8 2011 In addition, MW attenuated the PMACI-stimulated expression of pro-inflammatory cytokines such as tumor necrosis factor-alpha, interleukin-1beta (IL-1beta), IL-6, and IL-8 in human mast cells. pmaci 31-36 interleukin 6 Homo sapiens 156-160 21272678-12 2011 In human mononuclear leukocyte, isoforskolin (50, 100, and 200 muM) and dexamethasone (10 muM) pre-incubation lowered lipopolysaccharide (2 mug/mL) induced secretion of the cytokine TNF-alpha, and interleukins (IL)-1beta, IL-6, and IL-8. Dexamethasone 72-85 interleukin 6 Homo sapiens 222-226 21333594-0 2011 Role of interleukin-6 -174 G/C promoter polymorphism in trace metal levels of autopsy kidney and liver tissues. Metals 62-67 interleukin 6 Homo sapiens 8-21 21333594-2 2011 IL-6 also controls induction and expression of metallothioneins (MTs) which maintain homeostasis of zinc and copper. Copper 109-115 interleukin 6 Homo sapiens 0-4 21333594-5 2011 The aim of this study is to determine the IL-6 promoter polymorphism effect on trace element levels and toxic metal accumulation in the kidney and liver tissues. Metals 110-115 interleukin 6 Homo sapiens 42-46 20945380-9 2011 Treatment of microglia with AP-1 inhibitors (Tanshinone IIA and curcumin) effectively reduced PGN-induced IL-6 expression. Curcumin 64-72 interleukin 6 Homo sapiens 106-110 20945380-13 2011 Co-transfection with dominant negative mutant of JNK (DN-JNK), or treatment with SP600125, curcumin, or Tanshinone IIA effectively antagonized PGN-increased IL-6 transcription activity. Curcumin 91-99 interleukin 6 Homo sapiens 157-161 20945380-13 2011 Co-transfection with dominant negative mutant of JNK (DN-JNK), or treatment with SP600125, curcumin, or Tanshinone IIA effectively antagonized PGN-increased IL-6 transcription activity. tanshinone 104-118 interleukin 6 Homo sapiens 157-161 21487312-0 2011 Resistance and aerobic exercise: the influence of mode on the relationship between IL-6 and glucose tolerance in young men who are obese. Glucose 92-99 interleukin 6 Homo sapiens 83-87 21779731-0 2011 [Expression of IL-6 in cyclosporin A-induced gingival overgrowth]. Cyclosporine 23-36 interleukin 6 Homo sapiens 15-19 21136209-5 2011 The authors then performed an alanine scan analysis of CA11 and determined the amino acid residues necessary to interact with IL-6. Alanine 30-37 interleukin 6 Homo sapiens 126-130 21484436-0 2011 Grape seed proanthocyanidin extract inhibits interleukin-17-induced interleukin-6 production via MAPK pathway in human pulmonary epithelial cells. proanthocyanidin 11-27 interleukin 6 Homo sapiens 68-81 21484436-1 2011 This study was aimed to investigate the effect of grape seed proanthocyanidin extract (GSPE) on interleukin-17 (IL-17)-induced interleukin-6 (IL-6) production in A549 human pulmonary epithelial cells. proanthocyanidin 61-77 interleukin 6 Homo sapiens 127-140 21484436-1 2011 This study was aimed to investigate the effect of grape seed proanthocyanidin extract (GSPE) on interleukin-17 (IL-17)-induced interleukin-6 (IL-6) production in A549 human pulmonary epithelial cells. proanthocyanidin 61-77 interleukin 6 Homo sapiens 142-146 21779731-1 2011 PURPOSE: To estimate the role of IL-6 in cyclosporin A(CsA)-induced gingival overgrowth(GO) and collect the evidence of pathomechanism for CsA-induced GO. Cyclosporine 41-54 interleukin 6 Homo sapiens 33-37 21779731-1 2011 PURPOSE: To estimate the role of IL-6 in cyclosporin A(CsA)-induced gingival overgrowth(GO) and collect the evidence of pathomechanism for CsA-induced GO. Cyclosporine 55-58 interleukin 6 Homo sapiens 33-37 21779731-6 2011 The IL-6 expression of gingival epithelial cells and fibroblasts had no significance difference, but changed depending on the concentration and treated time with CsA. Cyclosporine 162-165 interleukin 6 Homo sapiens 4-8 21779731-7 2011 During the first 24h, there was no significant difference between the experimental and control groups of gingival fibroblasts, while after stimulation of 1000ng/mL CsA for 24h or longer, the secretion of IL-6 in gingival fibroblasts was significantly higher than the control group (P<0.05). Cyclosporine 164-167 interleukin 6 Homo sapiens 204-208 21779731-8 2011 CONCLUSIONS: IL-6 is not the main cytokine of gingival epithelial cells, IL-6 in CsA-induced GO probably secreted by the gingival fibroblasts; the effect of CsA on the secretion of IL-6 in the gingival epithelial cells and gingival fibroblasts is associated with the time and concentrations of CsA. Cyclosporine 81-84 interleukin 6 Homo sapiens 73-77 21779731-8 2011 CONCLUSIONS: IL-6 is not the main cytokine of gingival epithelial cells, IL-6 in CsA-induced GO probably secreted by the gingival fibroblasts; the effect of CsA on the secretion of IL-6 in the gingival epithelial cells and gingival fibroblasts is associated with the time and concentrations of CsA. Cyclosporine 81-84 interleukin 6 Homo sapiens 73-77 21393479-2 2011 In this highly prevalent form of anemia, inflammatory cytokines, including IL-6, stimulate hepatic expression of hepcidin, which negatively regulates iron bioavailability by inactivating ferroportin. Iron 150-154 interleukin 6 Homo sapiens 75-79 21458563-6 2011 The high glucose incubation increased NF-kappaB, RAGE and IL-6 expressions in HEK293 cells. Glucose 9-16 interleukin 6 Homo sapiens 58-62 21393479-9 2011 Our studies support the concept that BMP and IL-6 act together to regulate iron homeostasis and suggest that inhibition of BMP signaling may be an effective strategy for the treatment of anemia of inflammation. Iron 75-79 interleukin 6 Homo sapiens 45-49 21263314-14 2011 Tumor necrosis factor-alpha and interleukin-6 also delayed the diastolic calcium reuptake and decay in cardiomyocytes. Calcium 73-80 interleukin 6 Homo sapiens 32-45 21338338-7 2011 Furthermore, in the present paper we report a 3-fold increase in cellular levels of ROS (reactive oxygen species), in particular superoxide anion, mainly produced by DS-HSF mitochondria. Reactive Oxygen Species 84-87 interleukin 6 Homo sapiens 169-172 21338338-7 2011 Furthermore, in the present paper we report a 3-fold increase in cellular levels of ROS (reactive oxygen species), in particular superoxide anion, mainly produced by DS-HSF mitochondria. Reactive Oxygen Species 89-112 interleukin 6 Homo sapiens 169-172 21338338-7 2011 Furthermore, in the present paper we report a 3-fold increase in cellular levels of ROS (reactive oxygen species), in particular superoxide anion, mainly produced by DS-HSF mitochondria. Superoxides 129-145 interleukin 6 Homo sapiens 169-172 21338338-9 2011 Taken together, the results of the present study suggest that the drastic decrease in basal cAMP levels observed in DS-HSFs participates in the complex I deficit and overproduction of ROS by DS-HSF mitochondria. Cyclic AMP 92-96 interleukin 6 Homo sapiens 119-122 21338338-9 2011 Taken together, the results of the present study suggest that the drastic decrease in basal cAMP levels observed in DS-HSFs participates in the complex I deficit and overproduction of ROS by DS-HSF mitochondria. Reactive Oxygen Species 184-187 interleukin 6 Homo sapiens 119-122 21670915-8 2011 In addition, inhibition of nuclear factor kappaB by carbobenzoxyl-l-leucinyl-l-leucinyl-l-leucinal suppressed the secretion of interleukin-6 and monocyte chemoattractant protein-1 in the supernatants of S. aureus-infected human osteoblasts in a dose-dependent manner. carbobenzoxyl 52-65 interleukin 6 Homo sapiens 127-140 21605007-4 2011 RESULTS: At baseline, the purines AMP and hypoxanthine correlated with multiple inflammatory markers including neutrophil counts and the cytokines interleukin (IL)-6, IL-8, tumor necrosis factor alpha (TNF-alpha), and IL-1beta (r ranged from 0.41 to 0.66, all P < 0.05). Adenosine Monophosphate 34-37 interleukin 6 Homo sapiens 147-165 21540553-6 2011 N-acetyl-cysteine (NAC), an antioxidant that restores intracellular glutathione (GSH) concentrations, prevented the IL-6-induced inhibitory effect on D1- and D2-mediated T3 production, which suggests that IL-6 might function by depleting an intracellular thiol cofactor, perhaps GSH. Acetylcysteine 0-17 interleukin 6 Homo sapiens 116-120 21605009-6 2011 We also observed that cadmium induced elevated expression of epidermal growth factor receptor (EGFR) along with different proinflammatory cytokines like interleukin-1 beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6). Cadmium 22-29 interleukin 6 Homo sapiens 229-242 21605009-6 2011 We also observed that cadmium induced elevated expression of epidermal growth factor receptor (EGFR) along with different proinflammatory cytokines like interleukin-1 beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6). Cadmium 22-29 interleukin 6 Homo sapiens 244-248 21540553-6 2011 N-acetyl-cysteine (NAC), an antioxidant that restores intracellular glutathione (GSH) concentrations, prevented the IL-6-induced inhibitory effect on D1- and D2-mediated T3 production, which suggests that IL-6 might function by depleting an intracellular thiol cofactor, perhaps GSH. Acetylcysteine 0-17 interleukin 6 Homo sapiens 205-209 21540553-6 2011 N-acetyl-cysteine (NAC), an antioxidant that restores intracellular glutathione (GSH) concentrations, prevented the IL-6-induced inhibitory effect on D1- and D2-mediated T3 production, which suggests that IL-6 might function by depleting an intracellular thiol cofactor, perhaps GSH. Acetylcysteine 19-22 interleukin 6 Homo sapiens 116-120 21540553-6 2011 N-acetyl-cysteine (NAC), an antioxidant that restores intracellular glutathione (GSH) concentrations, prevented the IL-6-induced inhibitory effect on D1- and D2-mediated T3 production, which suggests that IL-6 might function by depleting an intracellular thiol cofactor, perhaps GSH. Acetylcysteine 19-22 interleukin 6 Homo sapiens 205-209 21540553-6 2011 N-acetyl-cysteine (NAC), an antioxidant that restores intracellular glutathione (GSH) concentrations, prevented the IL-6-induced inhibitory effect on D1- and D2-mediated T3 production, which suggests that IL-6 might function by depleting an intracellular thiol cofactor, perhaps GSH. Glutathione 68-79 interleukin 6 Homo sapiens 116-120 21540553-6 2011 N-acetyl-cysteine (NAC), an antioxidant that restores intracellular glutathione (GSH) concentrations, prevented the IL-6-induced inhibitory effect on D1- and D2-mediated T3 production, which suggests that IL-6 might function by depleting an intracellular thiol cofactor, perhaps GSH. Glutathione 81-84 interleukin 6 Homo sapiens 116-120 21540553-6 2011 N-acetyl-cysteine (NAC), an antioxidant that restores intracellular glutathione (GSH) concentrations, prevented the IL-6-induced inhibitory effect on D1- and D2-mediated T3 production, which suggests that IL-6 might function by depleting an intracellular thiol cofactor, perhaps GSH. Sulfhydryl Compounds 255-260 interleukin 6 Homo sapiens 116-120 21540553-6 2011 N-acetyl-cysteine (NAC), an antioxidant that restores intracellular glutathione (GSH) concentrations, prevented the IL-6-induced inhibitory effect on D1- and D2-mediated T3 production, which suggests that IL-6 might function by depleting an intracellular thiol cofactor, perhaps GSH. Glutathione 279-282 interleukin 6 Homo sapiens 116-120 21609290-11 2011 Furthermore, there was a significant correlation between changes in serum IL-6 levels and changes in fasting blood glucose levels (rho = 0.883; p = 0.0306). Glucose 115-122 interleukin 6 Homo sapiens 74-78 21223988-6 2011 Such enhanced effect was abrogated by incorporation of 2"-O-methyl (2"-OMe) uridine into the sequence of siRNA, probably via inhibiting cytokine induction such as IL-6 and TNF-alpha. 2'-O-methyluridine 55-83 interleukin 6 Homo sapiens 163-167 21178846-16 2011 PGE-2 synthesis was increased by IL-6 + sR, as was the induction of COX-2 mRNA. Dinoprostone 0-5 interleukin 6 Homo sapiens 33-37 21178846-17 2011 IL-6 + sR also enhanced IL-1 and TNF-alpha stimulated synthesis of PGE-2. Dinoprostone 67-72 interleukin 6 Homo sapiens 0-4 21288261-5 2011 Using two potent and selective inhibitors of MEK activation by Raf-1 (PD-098059) and p38 (SB-203580), it was also demonstrated that both ERK1/2 and p38 pathways play key roles in the production of IL-6 as well as in ICAM-1, VCAM-1 and E-selectin expression by Hib porin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 70-79 interleukin 6 Homo sapiens 197-201 21172926-8 2011 Treatment with SB202190 (p38-MAPK inhibitor) or PD98059 (ERK inhibitor) inhibited AGE-BSA-induced IL-6 and IL-8 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 48-55 interleukin 6 Homo sapiens 98-102 21695924-11 2011 There was a significantly negative correlation between IL-6 level and total cholesterol. Cholesterol 76-87 interleukin 6 Homo sapiens 55-59 21695924-15 2011 The cholesterol synthesis rate is negatively influenced by IL-6 level. Cholesterol 4-15 interleukin 6 Homo sapiens 59-63 21156217-5 2011 In laboratory parameters, vitamin D levels were inversely associated with serum IL-6 (p<0.001), IL-23 (p=0.011), IL-10 (p=0.033) cytokine levels, TM (p=0.001) and endothelin (p=0.033) levels. Vitamin D 26-35 interleukin 6 Homo sapiens 80-84 21255012-11 2011 When HCAEC were pre-treated with LPS for 24 hr, washed and challenged with histamine, 17-, 10- and 15-fold increases in PGI(2), PGE(2) and IL-6 production, respectively, were noted. Histamine 75-84 interleukin 6 Homo sapiens 139-143 21255012-2 2011 We have shown that histamine, acting via H1 receptors (H1R), synergizes lipopolysaccharide (LPS)-induced production of prostaglandin I(2) (PGI(2)), PGE(2) and interleukin-6 (IL-6) by endothelial cells. Histamine 19-28 interleukin 6 Homo sapiens 159-172 21255012-2 2011 We have shown that histamine, acting via H1 receptors (H1R), synergizes lipopolysaccharide (LPS)-induced production of prostaglandin I(2) (PGI(2)), PGE(2) and interleukin-6 (IL-6) by endothelial cells. Histamine 19-28 interleukin 6 Homo sapiens 174-178 21255012-12 2011 Histamine-induced enhancement of the synthesis of PGI(2), PGE(2) and IL-6 by LPS-primed HCAEC was completely blocked by an H1R antagonist. Histamine 0-9 interleukin 6 Homo sapiens 69-73 21239514-6 2011 In addition, testosterone was positively associated with CRP (P = 0.006), IL-6 (P = 0.001), and TNF-alpha (P = 0.0002). Testosterone 13-25 interleukin 6 Homo sapiens 74-78 20158569-11 2011 Combination of statins with aspirin and/or Indo resulted in complete inhibition of the synergistic IL-6 production. Aspirin 28-35 interleukin 6 Homo sapiens 99-103 22468044-7 2011 Future studies may focus on the effect of a-tocopheryl acetate or the phosphate form of Vitamin-E, recently proposed to be the more active form on other inflammatory markers like IL-6, an important stimuli of P-selectin release in pre-eclampsia. Phosphates 70-79 interleukin 6 Homo sapiens 179-183 20158569-8 2011 The standard anti-inflammatory drugs aspirin and indomethacin (Indo) reduced the synergistic IL-6 production by 60%. Aspirin 37-44 interleukin 6 Homo sapiens 93-97 20158569-9 2011 Simvastatin, atorvastatin, fluvastatin or pravastatin reduced the IL-6 production by 53%, 50%, 64% and 60%, respectively. Atorvastatin 13-25 interleukin 6 Homo sapiens 66-70 20717763-1 2011 We have previously shown that interleukin-6 (IL-6)-protected neurons against the suppression of neuronal vitality and overload of intracellular Ca(2+) induced by glutamate or N-methyl-D: -aspartate (NMDA). Glutamic Acid 162-171 interleukin 6 Homo sapiens 30-43 21346617-7 2011 An abnormal baseline IL-6 was a significant predictor of a greater increase in both total cholesterol (P < 0.01) and low-density lipoprotein (P < 0.01). Cholesterol 90-101 interleukin 6 Homo sapiens 21-25 20717763-1 2011 We have previously shown that interleukin-6 (IL-6)-protected neurons against the suppression of neuronal vitality and overload of intracellular Ca(2+) induced by glutamate or N-methyl-D: -aspartate (NMDA). Glutamic Acid 162-171 interleukin 6 Homo sapiens 45-49 21187140-10 2011 Pharmacological concentrations of cortisol (1000 nM) inhibited IL-6 production by SCC9 and SCC25 cells. Hydrocortisone 34-42 interleukin 6 Homo sapiens 63-67 21161336-3 2011 The current study examines whether difluorinated-curcumin (CDF), a novel analog of the dietary ingredient of curcumin, in combination with 5-fluorouracil and oxaliplatin (5-FU + Ox), the mainstay of colon cancer chemotherapeutic, would be effective in eliminating colon CSCs. Curcumin 49-57 interleukin 6 Homo sapiens 59-62 21161336-3 2011 The current study examines whether difluorinated-curcumin (CDF), a novel analog of the dietary ingredient of curcumin, in combination with 5-fluorouracil and oxaliplatin (5-FU + Ox), the mainstay of colon cancer chemotherapeutic, would be effective in eliminating colon CSCs. Fluorouracil 139-153 interleukin 6 Homo sapiens 59-62 22545184-5 2011 Recently, the multi-functional IL-6 is emerging as an important factor able to modulate bone, iron and inflammatory homeostasis.Here, we report an overview of Lf functions as well as for the first time Lf anti-inflammatory ability against periodontitis in in vitro model and observational clinical study. Iron 94-98 interleukin 6 Homo sapiens 31-35 21183736-3 2011 METHODS AND RESULTS: Manipulation of iron status with ferric ammonium citrate and hepcidin-25 induced monocyte chemoattractant protein (MCP)-1 and interleukin-6 in human differentiating monocytes of patients with hyperferritinemia associated with the metabolic syndrome (n=11), but not in subjects with hemochromatosis or HFE mutations impairing iron accumulation (n=15), and the degree of induction correlated with the presence of carotid plaques, detected by echocolor-Doppler. Iron 37-41 interleukin 6 Homo sapiens 147-160 21216561-5 2011 The results showed that atorvastatin significantly decreased the expression of six cytokines (IL-6, IL-8, IL-1, PAI-1, TGF-beta1, TGF-beta2) and five chemokines (CCL2, CCL7, CCL13, CCL18, CXCL1). Atorvastatin 24-36 interleukin 6 Homo sapiens 94-98 21077850-2 2011 We previously reported that BA inhibits lipopolysaccharide (LPS)-induced interleukin-6 production through modulation of nuclear factor kappaB (NF-kappaB) in human peripheral blood mononuclear cells (hPBMCs). betulinic acid 28-30 interleukin 6 Homo sapiens 73-86 21297151-12 2011 Interleukin-6 levels correlated with iron levels (r=-0.6, p=0.006) and transferrin saturations (r=-0.68, p=0.001) in idiopathic PAH but not in CTEPH. Iron 37-41 interleukin 6 Homo sapiens 0-13 21189358-6 2011 Dex suppressed genes in immune/inflammatory (IL-6, IL-8, and MCP-1, expressed in nonadipocytes) and proapoptotic pathways, yet induced genes related to the acute-phase response (SAA, factor D, haptoglobin, and RBP4, expressed in adipocytes) and stress/defense response. Dexamethasone 0-3 interleukin 6 Homo sapiens 45-49 21187140-11 2011 Cortisol dose that simulates stress conditions (10 nM) tended to increase IL-6 expression in SCC9 cells. Hydrocortisone 0-8 interleukin 6 Homo sapiens 74-78 20822828-5 2011 Kyn/trp correlated strongly with concentrations of cytokine IL-6, of soluble interleukin-2 receptor-alpha and 75 kDa TNF-alpha receptor and of the macrophage marker neopterin (all p<0.001 or p<0.01) but not with TNF-alpha. Tryptophan 4-7 interleukin 6 Homo sapiens 60-64 21111811-6 2011 GW280264X that targets both ADAM10 and ADAM17 blocked IL-6-induced proliferation and ERK1/2 phosphorylation with same potency as GM6001. GW280264X 0-9 interleukin 6 Homo sapiens 54-58 20604677-4 2011 The results indicated that beta-eudesmol inhibited the production and expression of interleukin (IL)-6 on phorbol 12-myristate 13-acetate and calcium ionophore A23187-stimulated human mast cell (HMC). Tetradecanoylphorbol Acetate 106-137 interleukin 6 Homo sapiens 84-102 21661448-7 2011 The IL-6 level of drain fluid was significantly higher in the ODG group than the LADG group (p<0.01) on POD1. ladg 81-85 interleukin 6 Homo sapiens 4-8 21062351-8 2011 Further, melatonin treatment also reduced the elevated levels of proinflammatory cytokines (TNF-alpha and IL-6), iNOS and COX-2 in sciatic nerves of animals. Melatonin 9-18 interleukin 6 Homo sapiens 106-110 21046223-4 2011 RESULTS: Significant positive correlations were observed between IL-6 with age (p = 0.035), and IL-6 with estradiol on the day of hCG (p = 0.011). Estradiol 106-115 interleukin 6 Homo sapiens 96-100 21485100-7 2011 ROS stimulates alveolar macrophages and neutrophils to release inflammatory cytokines, such as TNF-alpha, IL-8, IFN-gamma, IL-6 and IL-1beta. Reactive Oxygen Species 0-3 interleukin 6 Homo sapiens 123-127 20851655-14 2011 IL-6 diminishes the proportion of nucleated erythroid cells in the bone marrow and lowers the serum iron level, and these abnormalities can be corrected by administering an IL-6 antagonist. Iron 100-104 interleukin 6 Homo sapiens 0-4 20851655-14 2011 IL-6 diminishes the proportion of nucleated erythroid cells in the bone marrow and lowers the serum iron level, and these abnormalities can be corrected by administering an IL-6 antagonist. Iron 100-104 interleukin 6 Homo sapiens 173-177 21104991-2 2011 We have previously shown that, in certain cancer cell lines that are typically nonresponsive to cytokine-mediated IL6 induction, activation of the AHR with the agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin derepresses the IL6 promoter and allows for synergistic induction following IL1beta treatment. Polychlorinated Dibenzodioxins 168-203 interleukin 6 Homo sapiens 220-223 21302967-3 2011 This sesquiterpenoid inhibited the secretion and expression of IL-6 in phorbol 12-myristate 13-acetate- and calcium ionophore A23187-stimulated human mast cells (HMC)-1. Tetradecanoylphorbol Acetate 71-102 interleukin 6 Homo sapiens 63-67 21216930-6 2011 An interleukin-6 neutralizing antibody, siltuximab (CNTO 328) could inhibit STAT3 tyrosine phosphorylation in a cell-dependent manner. Tyrosine 82-90 interleukin 6 Homo sapiens 3-16 21441882-9 2011 Furthermore, patients from the hydrocortisone group had significantly lower levels of IL-6 (275 [162/677] pg/mL vs. 450 [320/660] pg/mL, P=0.001) and a shorter stay in the ICU (1 [1/3] day vs. 2 [2/3] days, P=0.04). Hydrocortisone 31-45 interleukin 6 Homo sapiens 86-90 20826742-6 2011 However, 48 h after intravenous iron administration, we observed a transient increase of tumour necrosis factor-alpha and interleukin-6 formation by unstimulated monocytes as compared with control subjects. Iron 32-36 interleukin 6 Homo sapiens 122-135 21364186-5 2011 The inflammatory cytokine interleukin-6 (IL-6) increased ATP synthesis and P2X7-mediated signaling in T(regs), which induced their conversion to IL-17-secreting T helper 17 (T(H)17) effector cells in vivo. Adenosine Triphosphate 57-60 interleukin 6 Homo sapiens 26-39 21364186-5 2011 The inflammatory cytokine interleukin-6 (IL-6) increased ATP synthesis and P2X7-mediated signaling in T(regs), which induced their conversion to IL-17-secreting T helper 17 (T(H)17) effector cells in vivo. Adenosine Triphosphate 57-60 interleukin 6 Homo sapiens 41-45 20962773-2 2011 We find that exposure of bronchiolar epithelial cells to pyocyanin results in MUC2/MUC5AC induction and mucin secretion through release of inflammatory cytokines and growth factors (interleukin (IL)-1beta, IL-6, heparin-bound epidermal growth factor, tissue growth factor-alpha, tumor necrosis factor-alpha) that activate the epidermal growth factor receptor pathway. Pyocyanine 57-66 interleukin 6 Homo sapiens 206-210 20713976-8 2011 Exposure of HPMC to 3.4-DGE resulted in suppression of HSP, and increased release of LDH, IL-6 and IL-8. hydroxypropylmethylcellulose-lactose matrix 12-16 interleukin 6 Homo sapiens 90-94 21302967-3 2011 This sesquiterpenoid inhibited the secretion and expression of IL-6 in phorbol 12-myristate 13-acetate- and calcium ionophore A23187-stimulated human mast cells (HMC)-1. Calcium 108-115 interleukin 6 Homo sapiens 63-67 20946124-11 2011 Dexamethasone (100 nM) partially inhibited release of both IL-6 and IL-8. Dexamethasone 0-13 interleukin 6 Homo sapiens 59-63 20843633-7 2011 Increasing carbon chain length of straight chain alcohols positively correlated with their ability to inhibit detection of tumor necrosis factor alpha (TNF-alpha) and interleukin 10 (IL-10), but not with the detection of interleukin 6 (IL-6), interleukin 8, (IL-8), and interleukin 12 (IL-12). Carbon 11-17 interleukin 6 Homo sapiens 236-240 21257314-7 2011 This is the first report of the inhibitory activity of endogenous fatty acid amides and their analogues on the production of nitric oxide, cytokines (IL-1beta, IL-6, and TNF-alpha) and the chemokine MDC. Fatty Acids 66-76 interleukin 6 Homo sapiens 160-164 20843633-7 2011 Increasing carbon chain length of straight chain alcohols positively correlated with their ability to inhibit detection of tumor necrosis factor alpha (TNF-alpha) and interleukin 10 (IL-10), but not with the detection of interleukin 6 (IL-6), interleukin 8, (IL-8), and interleukin 12 (IL-12). Alcohols 49-57 interleukin 6 Homo sapiens 236-240 21131394-10 2011 The changes in oxidant/antioxidant enzymes and IL-6 release were reversed by the antioxidants N-acetyl-cysteine (NAC) and ebselen through inhibition of Smad3 phosphorylation, indicating redox-dependent activation of Smad3 by TGF-beta. Acetylcysteine 94-111 interleukin 6 Homo sapiens 47-51 21131394-10 2011 The changes in oxidant/antioxidant enzymes and IL-6 release were reversed by the antioxidants N-acetyl-cysteine (NAC) and ebselen through inhibition of Smad3 phosphorylation, indicating redox-dependent activation of Smad3 by TGF-beta. Acetylcysteine 113-116 interleukin 6 Homo sapiens 47-51 21031343-0 2011 Effects of rosiglitazone/metformin fixed-dose combination therapy and metformin monotherapy on serum vaspin, adiponectin and IL-6 levels in drug-naive patients with type 2 diabetes. Rosiglitazone 11-24 interleukin 6 Homo sapiens 125-129 20595152-5 2011 Independent associated factors with an excess of IL-6 were neurologic disease, confusion, serum sodium < 130 mEq L-1, pleural effusion, and bacteraemia. Sodium 96-102 interleukin 6 Homo sapiens 49-53 21031343-7 2011 There was a considerable amelioration of hsCRP, WBC, adiponectin, IL-6, systolic and diastolic BP with rosiglitazone/metformin combined treatment as compared to baseline (p < 0.05) and MET group (p < 0.05). Rosiglitazone 103-116 interleukin 6 Homo sapiens 66-70 21031343-12 2011 CONCLUSIONS: Both rosiglitazone/metformin combination therapy and metformin monotherapy decreased serum vaspin levels through glucose and insulin sensitivity regulation, while they exerted differential effects on adiponectin, IL-6 and other cardiovascular risk factors in drug-naive patients with T2DM. Rosiglitazone 18-31 interleukin 6 Homo sapiens 226-230 21031343-12 2011 CONCLUSIONS: Both rosiglitazone/metformin combination therapy and metformin monotherapy decreased serum vaspin levels through glucose and insulin sensitivity regulation, while they exerted differential effects on adiponectin, IL-6 and other cardiovascular risk factors in drug-naive patients with T2DM. Metformin 66-75 interleukin 6 Homo sapiens 226-230 21088110-5 2011 Furthermore, excitation-coupled calcium entry induces generation of reactive nitrogen species and enhances nuclear localization of NFATc1, which in turn may be responsible for the increased IL-6 released by myotubes from patients with CCD. Calcium 32-39 interleukin 6 Homo sapiens 190-194 20953574-5 2011 Herein we report that Rab7b, a late endosome/lysosome-localized myeloid small GTPase, promotes phorbol-12-myristate-13-acetate (PMA)-induced megakaryocytic differentiation by increasing nuclear factor kappaB (NF-kappaB)-dependent IL-6 production and subsequently enhancing the association of activated signal transducer and activator of transcription 3 (STAT3) with GATA-1. Tetradecanoylphorbol Acetate 95-126 interleukin 6 Homo sapiens 230-234 20564534-10 2011 Although no correlation between FPN protein and IL-6 was noted, there was a strong negative correlation between serum iron and IL-6, both in subjects with CD (r=-0.88, P<0.0001) and those without anemia (r=-0.58, P=0.02). Iron 118-122 interleukin 6 Homo sapiens 127-131 21165548-3 2011 In the present study, we demonstrate that artemisinin inhibits the secretion and the mRNA levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1ss, and IL-6 in a dose-dependent manner in phorbol 12-myristate 13-acetate (PMA)-induced THP-1 human monocytes. Tetradecanoylphorbol Acetate 196-227 interleukin 6 Homo sapiens 161-165 20349206-4 2011 With RKO cells, aspirin reduced IL-6, IL-1ra, and IL-10 synthesis and enhanced IFNgamma secretion, while IL-1beta remained unchanged. Aspirin 16-23 interleukin 6 Homo sapiens 32-36 20953574-5 2011 Herein we report that Rab7b, a late endosome/lysosome-localized myeloid small GTPase, promotes phorbol-12-myristate-13-acetate (PMA)-induced megakaryocytic differentiation by increasing nuclear factor kappaB (NF-kappaB)-dependent IL-6 production and subsequently enhancing the association of activated signal transducer and activator of transcription 3 (STAT3) with GATA-1. Tetradecanoylphorbol Acetate 128-131 interleukin 6 Homo sapiens 230-234 20953574-9 2011 In Rab7b-silenced cells, PMA-induced activation of NF-kappaB, IL-6 production, and megakaryocytic differentiation are impaired. Tetradecanoylphorbol Acetate 25-28 interleukin 6 Homo sapiens 62-66 21129426-2 2011 The present study attempted to correlate the serum levels of total ghrelin with serum TNF-alpha and IL-6, and with nutritional status and body composition in HD patients. Ghrelin 67-74 interleukin 6 Homo sapiens 100-104 21129426-7 2011 There was a positive correlation between ghrelin levels and TNF-alpha (r=0.25; p<0.04), IL-6 (r=0.42; p<0.02), and a negative correlation between TNF-alpha and protein intake (r=-0.28; p<0.03), and energy intake (r=-0.34; p<0.01). Ghrelin 41-48 interleukin 6 Homo sapiens 91-95 21097658-10 2011 Good sleepers who consumed moderate amounts of alcohol had the lowest concentrations of IL-6 compared with the other three groups who consumed alcohol. Alcohols 47-54 interleukin 6 Homo sapiens 88-92 21144584-0 2011 Effect of IL-6 and TNF-alpha on fatty acid uptake in cultured human primary trophoblast cells. Fatty Acids 32-42 interleukin 6 Homo sapiens 10-14 21144584-3 2011 We tested the hypothesis that interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha stimulate placental fatty acid transport, as these pro-inflammatory cytokines have been shown to affect lipid metabolism in other tissues. placental fatty acid 97-117 interleukin 6 Homo sapiens 30-48 21144584-4 2011 In cultured primary human trophoblast cells IL-6, but not TNF-alpha, stimulated fatty acid accumulation, as measured by BODIPY fluorescence. Fatty Acids 80-90 interleukin 6 Homo sapiens 44-48 21144584-8 2011 In conclusion, high levels of IL-6 stimulate trophoblast fatty acid accumulation, which could contribute to an excessive nutrient transfer in conditions associated with elevated maternal IL-6 such as obesity and gestational diabetes. Fatty Acids 57-67 interleukin 6 Homo sapiens 30-34 21144584-8 2011 In conclusion, high levels of IL-6 stimulate trophoblast fatty acid accumulation, which could contribute to an excessive nutrient transfer in conditions associated with elevated maternal IL-6 such as obesity and gestational diabetes. Fatty Acids 57-67 interleukin 6 Homo sapiens 187-191 20739465-10 2011 Hypertonicity-induced increases in IL-6 and IL-8 releases were suppressed by exposure to capsazepine, AG 1478, ERK inhibitor PD 98059, p38 inhibitor SB 203580, or NF-kappaB inhibitor PDTC. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 125-133 interleukin 6 Homo sapiens 35-39 20621335-4 2011 Refractoriness to therapy with corticosteroids and cyclosporine A led to the use of humanized monoclonal anti-interleukin-6 receptor antibody "tocilizumab" with dramatic response. Cyclosporine 51-65 interleukin 6 Homo sapiens 110-123 21186817-4 2011 The results showed that p-coumaric acid, quercetin, and resveratrol have greater inhibition (p < 0.05) of a TNF-alpha-induced increase in the production of interleukin-6 (IL-6) among 21 tested polyphenolic compounds. Resveratrol 56-67 interleukin 6 Homo sapiens 159-172 21186817-4 2011 The results showed that p-coumaric acid, quercetin, and resveratrol have greater inhibition (p < 0.05) of a TNF-alpha-induced increase in the production of interleukin-6 (IL-6) among 21 tested polyphenolic compounds. Resveratrol 56-67 interleukin 6 Homo sapiens 174-178 20661185-7 2011 Sulfide also lowered the blood IL-6, IL-1beta, and nitrite + nitrate concentrations, which coincided with reduced kidney oxidative DNA base damage and iNOS expression, and attenuated glomerular histological injury as assessed by the incidence of glomerular tubularization. Sulfides 0-7 interleukin 6 Homo sapiens 31-35 21283681-1 2011 BACKGROUND/AIMS: Hepcidin (gene name HAMP), an IL-6-inducible acute phase peptide with antimicrobial properties, is the key negative regulator of iron metabolism. Iron 146-150 interleukin 6 Homo sapiens 47-51 20974848-7 2011 IL-6-stimulated cytoplasmic localization was mediated by alterations in the C-terminal M9 peptide of A1, and this correlated with the ability of IL-6 to induce serine phosphorylation of this domain. Serine 160-166 interleukin 6 Homo sapiens 145-149 21123455-6 2011 Selective blockade of the MAPK pathway with ERK inhibitor PD98059 reduced IL-6/sIL-6Ralpha-mediated endothelial hyperpermeability. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 58-65 interleukin 6 Homo sapiens 74-78 21123455-8 2011 Selective targeting of IL-6 trans-signaling in vivo reduced ascites formation and enhanced the taxane sensitivity of intraperitoneal human ovarian tumor xenografts in mice. taxane 95-101 interleukin 6 Homo sapiens 23-27 21148032-5 2011 Furthermore, cisplatin increased the interaction between TLR4 and its microbial ligand LPS, thereby upregulating the production of proinflammatory cytokines, such as TNF-alpha, IL-1beta, and IL-6, via NF-kappaB activation. Cisplatin 13-22 interleukin 6 Homo sapiens 191-195 20974848-7 2011 IL-6-stimulated cytoplasmic localization was mediated by alterations in the C-terminal M9 peptide of A1, and this correlated with the ability of IL-6 to induce serine phosphorylation of this domain. Serine 160-166 interleukin 6 Homo sapiens 0-4 20958132-6 2011 RESULTS: When it was acupunctured at the Ermen acupoint (triple energizer meridian 21) after an administration of cisplatin, PBS-pharmaceutical acupuncture significantly suppressed interleukin (IL)-6 production and caspase-3 activation induced by cisplatin in the cochlea. Cisplatin 114-123 interleukin 6 Homo sapiens 181-199 22024524-2 2011 It was reported recently that IL-6 is associated with insulin resistance, iron metabolism and interferon resistance, which may affect the outcome of antiviral treatment. Iron 74-78 interleukin 6 Homo sapiens 30-34 21273582-0 2011 Overexpression of Interleukin-6 suppresses cisplatin-induced cytotoxicity in esophageal squamous cell carcinoma cells. Cisplatin 43-52 interleukin 6 Homo sapiens 18-31 21273582-4 2011 The sensitivity of IL-6 transfectants to cisplatin was evaluated using a WST-8 assay and cell-cycle analysis. Cisplatin 41-50 interleukin 6 Homo sapiens 19-23 21273582-6 2011 IL-6 transfectants showed significantly reduced sensitivity to cisplatin compared to control transfectants. Cisplatin 63-72 interleukin 6 Homo sapiens 0-4 21273582-7 2011 In addition, the reduced cisplatin sensitivity of IL-6 transfectants was restored by pretreatment with IL-6-specific siRNA. Cisplatin 25-34 interleukin 6 Homo sapiens 50-54 21273582-7 2011 In addition, the reduced cisplatin sensitivity of IL-6 transfectants was restored by pretreatment with IL-6-specific siRNA. Cisplatin 25-34 interleukin 6 Homo sapiens 103-107 21550026-8 2011 Furthermore, intermittent exposure of FATEII cells to the exogenous oxidants X/XO and H(2)O(2) upregulated the secretion of pro-inflammatory cytokines IL-1beta, IL-6 and TNF-alpha; this upregulation was correlated with increasing activity of key glutathione-related enzymes, closely involved with maintaining the cyclic GSH/GSSG equilibrium. Hydrogen Peroxide 86-94 interleukin 6 Homo sapiens 161-165 21273582-8 2011 These results suggest that intracellular IL-6 expression in tumor cells may acts as a resistance factor against cisplatin-based treatments for esophageal cancer. Cisplatin 112-121 interleukin 6 Homo sapiens 41-45 20934464-5 2011 Injury in the presence of HSF decoy, a synthetic oligonucleotide identical to the heat shock element, the nuclear binding site of HSF, decreased HSP70 induction by 80% without affecting the over-expression of transfected HSP27. Oligonucleotides 49-64 interleukin 6 Homo sapiens 26-29 20934464-5 2011 Injury in the presence of HSF decoy, a synthetic oligonucleotide identical to the heat shock element, the nuclear binding site of HSF, decreased HSP70 induction by 80% without affecting the over-expression of transfected HSP27. Oligonucleotides 49-64 interleukin 6 Homo sapiens 130-133 21628878-2 2011 SA significantly inhibited phorbol myristate acetate (PMA) plus A23187-induced the production and expression of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha in human mast cell (HMC)-1 cells. Tetradecanoylphorbol Acetate 27-52 interleukin 6 Homo sapiens 112-130 21628878-2 2011 SA significantly inhibited phorbol myristate acetate (PMA) plus A23187-induced the production and expression of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha in human mast cell (HMC)-1 cells. Tetradecanoylphorbol Acetate 54-57 interleukin 6 Homo sapiens 112-130 21525597-5 2011 Using cytokine protein arrays and real time gene expression analysis, we indeed found that low oxygen exposure increased expression of characteristic macrophage inflammatory cytokines such as IL-1, IL-6, and TNF-alpha. Oxygen 95-101 interleukin 6 Homo sapiens 198-202 20844277-10 2011 The SIRT1 activators resveratrol and SRT1720 significantly decreased LPS-induced TNF, IL6, and IL8 gene expression and release and PTGS2 mRNA expression and resultant prostaglandin (PG) E(2) and PGF(2alpha) release from human gestational tissues. Resveratrol 21-32 interleukin 6 Homo sapiens 86-89 23008706-10 2011 The free testosterone had significant negative correlation with fibrinogen, PAI-1, hsCRP and IL-6 in both groups of patients. Testosterone 9-21 interleukin 6 Homo sapiens 93-97 22121382-8 2011 Salmeterol increased, while dexamethasone and fluticasone decreased RV-induced IL-6 and IL-8 (P<0.05). Dexamethasone 28-41 interleukin 6 Homo sapiens 79-83 21755056-9 2011 Patients with dialysate/plasma creatinine 0.82 showed significantly higher effluent HGF (240 versus 133 pg/mL, P < .001), VEGF, IL-6, and IL6/CA125 levels than the others but no significant differences in effluent HGF/CA125, BMP-7, and BMP7/CA125 were observed. Creatinine 31-41 interleukin 6 Homo sapiens 132-136 21755056-9 2011 Patients with dialysate/plasma creatinine 0.82 showed significantly higher effluent HGF (240 versus 133 pg/mL, P < .001), VEGF, IL-6, and IL6/CA125 levels than the others but no significant differences in effluent HGF/CA125, BMP-7, and BMP7/CA125 were observed. Creatinine 31-41 interleukin 6 Homo sapiens 142-145 20956498-10 2011 Furthermore, metformin decreased IL-6 and MCP-1 gene expression in comparison with differentiated adipocytes. Metformin 13-22 interleukin 6 Homo sapiens 33-37 20880729-1 2011 OBJECTIVES: Modulation of abdominal aortic aneurysm (AAA) expansion by HMG-CoA reductase inhibitors (statins) might be linked to reducing IL-6 and MMP-9, which may be consequent on reducing plasma cholesterol. Cholesterol 197-208 interleukin 6 Homo sapiens 138-142 20943775-4 2011 Nicotine (100-300 nM, concentrations found in smoker"s blood) blocked LPS-induced NF-kappaB translocation and production of PICs interleukin (IL)-1beta and IL-6 but only partially blocked inhibitor of nuclear factor-kappaBalpha (IkappaBalpha) phosphorylation. Nicotine 0-8 interleukin 6 Homo sapiens 156-160 21815057-5 2011 This chapter describes methods for expressing fluorescent chimeric proteins in astrocytes and astrocytoma cells in order to examine the metal-induced cytosolic redistribution of Hspa5, as well as associated effects on the secretion of interleukin-6 (IL-6). Metals 136-141 interleukin 6 Homo sapiens 235-248 21815057-5 2011 This chapter describes methods for expressing fluorescent chimeric proteins in astrocytes and astrocytoma cells in order to examine the metal-induced cytosolic redistribution of Hspa5, as well as associated effects on the secretion of interleukin-6 (IL-6). Metals 136-141 interleukin 6 Homo sapiens 250-254 21062339-7 2011 In HS group, GCF and serum IL-6 were positively correlated with BOP% and TC/HDL. Hydrogen 3-5 interleukin 6 Homo sapiens 27-31 19560161-9 2011 In patients with sepsis, levels of IL-6 correlated with syndecan-1, ICAM-1, VCAM-1, and lactate, while ICAM-1 furthermore correlated with CRP and lactate levels. Lactic Acid 88-95 interleukin 6 Homo sapiens 35-39 19560161-9 2011 In patients with sepsis, levels of IL-6 correlated with syndecan-1, ICAM-1, VCAM-1, and lactate, while ICAM-1 furthermore correlated with CRP and lactate levels. Lactic Acid 146-153 interleukin 6 Homo sapiens 35-39 21194184-0 2011 A multiple-dose pharmacokinetics of polyethylene glycol recombinant human interleukin-6 (PEG-rhIL-6) in rats. Polyethylene Glycols 36-55 interleukin 6 Homo sapiens 74-87 21954641-1 2011 The use of metformin during the first month of treatment of patients with coronary artery disease and diabetes type 2 led to the decrease of insulin resistance and reduced activity of systemic inflammation (significant decrease in the concentrations of IL-1, IL-6, IL-8 and TNF-alpha). Metformin 11-20 interleukin 6 Homo sapiens 259-263 22013287-2 2011 The phospholipid mediator platelet-activating factor (PAF) is found in increased concentrations in inflammatory lesions and has been shown to induce IL-6 production. Phospholipids 4-16 interleukin 6 Homo sapiens 149-153 22171160-7 2011 RESULTS: Capsaicin (CAP; a selective TRPV1 agonist), induced time-dependent activation of transforming growth factor-activated kinase 1 (TAK1) and mitogen-activated protein kinase (MAPK) cascades temporally followed by increased nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha) phosphorylation, rises in both PKCdelta protein levels and IL-6 and IL-8 release. Capsaicin 9-18 interleukin 6 Homo sapiens 387-391 22065919-7 2011 IL-6 levels decreased in dexamethasone group and anti-oxidants group. Dexamethasone 25-38 interleukin 6 Homo sapiens 0-4 20978825-3 2011 In response to IL-6, the signal transducer and activator of transcription 3 (STAT3) becomes phosphorylated on tyrosine and serine residues. Tyrosine 110-118 interleukin 6 Homo sapiens 15-19 20978825-3 2011 In response to IL-6, the signal transducer and activator of transcription 3 (STAT3) becomes phosphorylated on tyrosine and serine residues. Serine 123-129 interleukin 6 Homo sapiens 15-19 22219634-9 2011 The result of ELISA also showed that the release of IL-6 and IL-8 can be inhibited by high glucose, but these inhibitions were partly counteracted after pretreatment with anti-TLR2 and/or anti-TLR4 monoclonal antibody. Glucose 91-98 interleukin 6 Homo sapiens 52-56 22171160-7 2011 RESULTS: Capsaicin (CAP; a selective TRPV1 agonist), induced time-dependent activation of transforming growth factor-activated kinase 1 (TAK1) and mitogen-activated protein kinase (MAPK) cascades temporally followed by increased nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha) phosphorylation, rises in both PKCdelta protein levels and IL-6 and IL-8 release. Capsaicin 20-23 interleukin 6 Homo sapiens 387-391 20939853-8 2011 Preoperative glycine injection significantly reduced the induction of interleukin-6 (IL-6), tumor necrosis factor-alpha, inducible nitric oxide synthase and intercellular adhesion molecule-1 mRNAs, which was associated with the attenuation in postoperative leukocyte recruitment. Glycine 13-20 interleukin 6 Homo sapiens 70-83 20624775-7 2011 Testosterone was strongly and inversely correlated to inflammatory markers (CRP, IL-6 and fibrinogen), even after correction for age and sex hormone-binding globulin. Testosterone 0-12 interleukin 6 Homo sapiens 81-100 20939853-8 2011 Preoperative glycine injection significantly reduced the induction of interleukin-6 (IL-6), tumor necrosis factor-alpha, inducible nitric oxide synthase and intercellular adhesion molecule-1 mRNAs, which was associated with the attenuation in postoperative leukocyte recruitment. Glycine 13-20 interleukin 6 Homo sapiens 85-89 20939853-10 2011 The secretion of the inflammatory proteins IL-6, monocyte chemotactic protein-1/chemokine ligand 2 and macrophage inflammatory protein-1alpha/chemokine ligand 3 were also significantly decreased by glycine pretreatment. Glycine 198-205 interleukin 6 Homo sapiens 43-47 22096605-0 2011 Interleukin-6 synthesis in human chondrocytes is regulated via the antagonistic actions of prostaglandin (PG)E2 and 15-deoxy-Delta(12,14)-PGJ2. Dinoprostone 91-111 interleukin 6 Homo sapiens 0-13 24331010-5 2011 IL-6 at a concentration comparable to that in CM from visceral fat reduced insulin-stimulated glucose uptake by 53% (P < 0.05), an effect abolished by inhibiting NFkappaB or mTORC1. Glucose 94-101 interleukin 6 Homo sapiens 0-4 22096605-2 2011 PGE(2) directly stimulates IL-6 production in human articular chondrocytes. Dinoprostone 0-6 interleukin 6 Homo sapiens 27-31 22096605-8 2011 PGD(2) or 15d-PGJ(2) concurrently downregulates TLR4 and upregulates caveolin-1, which in turn inhibit the PGE(2)-dependent ERK1/2, PI3-K and PKA activation, and ultimately with NF-kappaB-dependent IL-6 synthesis in chondrocytes. Dinoprostone 107-113 interleukin 6 Homo sapiens 198-202 21151599-14 2010 FDP-lysine accumulation was associated with the induction of HO-1, no change in GFAP, a decrease in protein levels of the potassium channel subunit Kir4.1, and upregulation of transcripts for VEGF, IL-6, and TNF-alpha. Lysine 4-10 interleukin 6 Homo sapiens 198-202 21799929-0 2011 Interleukin-6 contributes to inflammation and remodeling in a model of adenosine mediated lung injury. Adenosine 71-80 interleukin 6 Homo sapiens 0-13 21799929-3 2011 Adenosine signaling increases the production of the pro-fibrotic cytokine interleukin-6 (IL-6). Adenosine 0-9 interleukin 6 Homo sapiens 74-87 21799929-3 2011 Adenosine signaling increases the production of the pro-fibrotic cytokine interleukin-6 (IL-6). Adenosine 0-9 interleukin 6 Homo sapiens 89-93 21799929-4 2011 Based on these observations, we hypothesized that IL-6 signaling contributes to tissue destruction and remodeling in a model of chronic lung disease where adenosine levels are elevated. Adenosine 155-164 interleukin 6 Homo sapiens 50-54 21799929-8 2011 CONCLUSIONS/SIGNIFICANCE: These findings demonstrate that adenosine enhances IL-6 signaling pathways to promote aspects of chronic lung disease. Adenosine 58-67 interleukin 6 Homo sapiens 77-81 21779360-4 2011 Our findings showed that pretreatment of HaCaT cells with NaHS (a donor of H(2)S) for 30 min before exposure to CoCl(2) for 24 h significantly attenuated CoCl(2)-induced injuries and inflammatory responses, evidenced by increases in cell viability and GSH level and decreases in ROS generation and secretions of IL-1beta, IL-6 and IL-8. sodium bisulfide 58-62 interleukin 6 Homo sapiens 322-326 21625522-2 2011 Cytokines such as interleukin-6 and interferon stimulate the specific tyrosine phosphorylation of STAT3, which confers its ability to bind consensus DNA targets. Tyrosine 70-78 interleukin 6 Homo sapiens 18-31 21455087-3 2011 We looked to assess the efficacy of low-dose steroids on the postinflammatory response as measured by IL-6 in patients undergoing bilateral total knee replacement (BTKR). Steroids 45-53 interleukin 6 Homo sapiens 102-106 21455087-13 2011 CONCLUSIONS: The use of hydrocortisone significantly decreased the inflammatory response in patients undergoing BTKR as measured by IL-6 production. Hydrocortisone 24-38 interleukin 6 Homo sapiens 132-136 21209948-0 2010 PGE2 induces IL-6 in orbital fibroblasts through EP2 receptors and increased gene promoter activity: implications to thyroid-associated ophthalmopathy. Dinoprostone 0-4 interleukin 6 Homo sapiens 13-17 21209948-4 2010 METHODOLOGY/PRINCIPAL FINDINGS: Using cultured orbital and dermal fibroblasts, we characterized the effects of PGE(2) on IL-6 expression. Dinoprostone 111-117 interleukin 6 Homo sapiens 121-125 21209948-5 2010 We found that the prostanoid provokes substantially greater cytokine synthesis in orbital fibroblasts, effects that are mediated through cell-surface EP(2) receptors and increased steady-state IL-6 mRNA levels. Prostaglandins 18-28 interleukin 6 Homo sapiens 193-197 21957456-5 2011 PGE2 further enhanced the tumor promoting properties of fibroblasts by increasing secretion of IL-6, which was necessary, but not sufficient, for expansion of breast cancer stem-like cells. Dinoprostone 0-4 interleukin 6 Homo sapiens 95-99 21625597-2 2011 We report that, in human THP-1 cell line, they inhibit IL-6-elicited tyrosine phosphorylation of STAT3 and its DNA binding activity with EC(50) of 10 microM with concomitant down-regulation of the phosphorylation of the tyrosine Janus kinases JAK1, JAK2 and Tyk2. Tyrosine 69-77 interleukin 6 Homo sapiens 55-59 21387693-9 2011 The initiation of usual dose of atorvastatin early after the onset of ischemic stroke significantly decreased the elevation of IL-6 and may protect against the early neurological deterioration. Atorvastatin 32-44 interleukin 6 Homo sapiens 127-131 21387693-11 2011 Further studies wherein IL-6 levels are monitored in larger samples would be feasible for investigating the effect of early treatment with usual dose of atorvastatin on the functional outcome. Atorvastatin 153-165 interleukin 6 Homo sapiens 24-28 21355310-0 2011 [Influence of high glucose and mannose binding lectin complement pathway activation to IL-6 and TNF-alpha"s expression by human renal glomerular endothelial cells]. Glucose 19-26 interleukin 6 Homo sapiens 87-91 21355310-1 2011 OBJECTIVE: To investigate the effect of high glucose and mannose binding lectin (MBL) complement pathway activation"s effect on expression of Interleukin-6 (IL-6) and Tumor necrosis factor-alpha (TNF-alpha) from human renal glomerular endothelial cells (HRGEC), to explore unknown pathogenesy of diabetic nephropathy. Glucose 45-52 interleukin 6 Homo sapiens 142-155 21355310-1 2011 OBJECTIVE: To investigate the effect of high glucose and mannose binding lectin (MBL) complement pathway activation"s effect on expression of Interleukin-6 (IL-6) and Tumor necrosis factor-alpha (TNF-alpha) from human renal glomerular endothelial cells (HRGEC), to explore unknown pathogenesy of diabetic nephropathy. Glucose 45-52 interleukin 6 Homo sapiens 157-161 21355310-8 2011 RESULTS: Compared with normal glucose group and manicol group, the mRNA and protein expression of IL-6 and TNF-alpha in high glucose group were increased (P < 0.05). Glucose 30-37 interleukin 6 Homo sapiens 98-102 21355310-8 2011 RESULTS: Compared with normal glucose group and manicol group, the mRNA and protein expression of IL-6 and TNF-alpha in high glucose group were increased (P < 0.05). Glucose 125-132 interleukin 6 Homo sapiens 98-102 21355310-10 2011 Compared with single high glucose group, the mRNA and protein expression of IL-6 and TNF-alpha in high glucose+ MBL group were significantly higher (P < 0.05). Glucose 26-33 interleukin 6 Homo sapiens 76-80 21355310-10 2011 Compared with single high glucose group, the mRNA and protein expression of IL-6 and TNF-alpha in high glucose+ MBL group were significantly higher (P < 0.05). Glucose 103-110 interleukin 6 Homo sapiens 76-80 21122157-10 2010 In AS2 derived cells, resistance to paclitaxel was positively correlated with Stat3 activation status and the expression of IL-6, which is commonly secreted in drug resistant cancer cells. Paclitaxel 36-46 interleukin 6 Homo sapiens 124-128 21071695-5 2010 Preincubation with thrombin significantly enhanced the efficacy of the P2Y receptor agonist 2-methylthio-ADP to induce interleukin 6 expression and SMC mitogenesis. methylthio-ADP 92-108 interleukin 6 Homo sapiens 119-132 20827783-7 2010 RESULTS: After controlling for age at blood collection, smoking, parity and duration of breastfeeding, menopausal status, oral contraceptive use, body mass index, and the time between blood collection and RA onset, we found that the daily alcohol consumption showed a U-shaped association with IL-6 levels in RA patients, prior to symptoms. Alcohols 239-246 interleukin 6 Homo sapiens 294-298 20827783-9 2010 CONCLUSION: These results demonstrate an association between alcohol consumption and markers of inflammation, including IL-6 and sTNFRII, in RA patients, prior to the occurrence of symptoms. Alcohols 61-68 interleukin 6 Homo sapiens 120-124 21084670-3 2010 Several immune-related genes possess this cAMP-responsive element, including IL-2, IL-6, IL-10, and TNF-alpha. Cyclic AMP 42-46 interleukin 6 Homo sapiens 83-87 21030257-1 2010 A small library of pyrrolidinesulphonylaryl molecules has been synthesized via an efficient 4-step route, and members evaluated for their ability to inhibit IL-6 signalling. pyrrolidinesulphonylaryl 19-43 interleukin 6 Homo sapiens 157-161 21084246-0 2010 Effect of omeprazole on the concentration of interleukin-6 and transforming growth factor-beta1 in patients receiving dual antiplatelet therapy after percutaneous coronary intervention. Omeprazole 10-20 interleukin 6 Homo sapiens 45-58 20843944-9 2010 We confirmed significant down-regulation of a number of genes that have been well characterized as progesterone sensitive (IL-1B, IL-6, PTGS2, and GJA1). Progesterone 99-111 interleukin 6 Homo sapiens 130-134 20951370-8 2010 Hydrocortisone administration significantly reduced IL-6 levels in both PTSD groups; however, IL-6 levels in PTSD + MDD were higher than both PTSD - MDD (p < .05) and healthy control subjects (p < .01). Hydrocortisone 0-14 interleukin 6 Homo sapiens 52-56 20951370-8 2010 Hydrocortisone administration significantly reduced IL-6 levels in both PTSD groups; however, IL-6 levels in PTSD + MDD were higher than both PTSD - MDD (p < .05) and healthy control subjects (p < .01). Hydrocortisone 0-14 interleukin 6 Homo sapiens 94-98 20934787-4 2010 In this study, 33 novel mono-carbonyl analogues of curcumin were synthesized and their inhibition against TNF-alpha and IL-6 release was evaluated in LPS-stimulated RAW 264.7 macrophages. Curcumin 51-59 interleukin 6 Homo sapiens 120-124 20887798-4 2010 Microarray analysis revealed that myostatin upregulates several genes involved in regulating glucose metabolism such as Glut1, Glut4, Hk2, and IL-6. Glucose 93-100 interleukin 6 Homo sapiens 143-147 20930550-0 2010 STAT3 transcriptional factor activated by reactive oxygen species induces IL6 in starvation-induced autophagy of cancer cells. Reactive Oxygen Species 42-65 interleukin 6 Homo sapiens 74-77 21129557-8 2010 RESULTS: Eicosapentaenoic acid effectively reduced LPS-induced or PGE(2)-induced TNF-alpha and IL-6 expression, and increased IL-10 expression significantly when compared with arachidonic acid. Dinoprostone 66-72 interleukin 6 Homo sapiens 95-99 20725805-6 2010 In all compartments, IL-6 levels appeared to be higher in symptomatic patients, accompanied also by a higher ECF lactate-pyruvate ratio (P = 0.04). Lactic Acid 113-120 interleukin 6 Homo sapiens 21-25 20876575-4 2010 We found that tyrosine 204 of the SOCS box, the SH2 domain, and the N-terminal kinase inhibitory region (KIR) of SOCS3 were all involved in its IL-6 inhibition. Tyrosine 14-22 interleukin 6 Homo sapiens 144-148 21067602-12 2010 In contrast, CFA injection led to minor microglial morphological changes and an induction of IkappaB-alpha mRNA in the CVO regions; a significant increase in IL-1beta and IL-6 mRNA started only at 48 hours post-injection, when the induced pain-related behavior started to resolve. 3-chloro-4-fluoroaniline 13-16 interleukin 6 Homo sapiens 171-175 20826566-4 2010 When cells were pretreated with dexamethasone, a prototypic glucocorticoid, ATP-induced IL-6 production was enhanced in a time- and dose-dependent manner. Dexamethasone 32-45 interleukin 6 Homo sapiens 88-92 20826566-4 2010 When cells were pretreated with dexamethasone, a prototypic glucocorticoid, ATP-induced IL-6 production was enhanced in a time- and dose-dependent manner. Adenosine Triphosphate 76-79 interleukin 6 Homo sapiens 88-92 20826566-7 2010 Cells treated with dexamethasone induced mRNA expression of the purinergic P2Y(2) receptor (P2Y(2)R) 1.8- +- 0.1-fold and, when stimulated with ATP, enhanced Ca(2+) release and augmented IL-6 mRNA expression. Dexamethasone 19-32 interleukin 6 Homo sapiens 187-191 20826566-7 2010 Cells treated with dexamethasone induced mRNA expression of the purinergic P2Y(2) receptor (P2Y(2)R) 1.8- +- 0.1-fold and, when stimulated with ATP, enhanced Ca(2+) release and augmented IL-6 mRNA expression. Adenosine Triphosphate 144-147 interleukin 6 Homo sapiens 187-191 20826566-8 2010 Silencing of the P2Y(2)R by its small interfering RNA decreased ATP-induced IL-6 production by 81 +- 1% (p < 0.001). Adenosine Triphosphate 64-67 interleukin 6 Homo sapiens 76-80 21170263-3 2010 Dex was found to inhibit the release of interleukin-6 from irradiated BMSCs, which is an established myeloma cell proproliferative cytokine. Dexamethasone 0-3 interleukin 6 Homo sapiens 40-53 21078494-10 2010 Nicotine not only failed to stimulate production of TNF-alpha, IL-8, and IL-6, but its presence was shown to suppress the activation resulting from exposure to CE and LPS (P < 0.05). Nicotine 0-8 interleukin 6 Homo sapiens 73-77 20206681-8 2010 ATP led to a decrease in LPS-induced pro-inflammatory cytokine release (TNFalpha, IL-6) in both microglia and macrophages without suppression of an anti-inflammatory response (IL-10). Adenosine Triphosphate 0-3 interleukin 6 Homo sapiens 82-86 21831781-7 2010 In addition, in human nutritional experiments we observed that whole grain products could counteract a glucose-induced tumour necrosis factor alpha and interleukin-6 increase which was associated with increased plasma butyrate concentrations. Glucose 103-110 interleukin 6 Homo sapiens 152-165 20652679-2 2010 METHODS: IL-6-stimulated expression of the genes for acute-phase response markers serum amyloid A (SAA1, SAA2) and haptoglobin (HP) in the human hepatocarcinoma cell line HepG2 were quantified after modulation of AMPK activity by pharmacological agonists (5-amino-4-imidazole-carboxamideriboside [AICAR], metformin) or by using small interfering (si) RNA transfection. Metformin 305-314 interleukin 6 Homo sapiens 9-13 20724373-3 2010 The WA treatment (2 and 4 muM) decreased constitutive (MDA-MB-231) and/or IL-6-inducible (MDA-MB-231 and MCF-7) phosphorylation of STAT3 (Tyr(705)) and its upstream regulator Janus-activated kinase 2 (JAK2; Tyr(1007/1008)) in MDA-MB-231, which was accompanied by suppression of their protein levels especially at the higher concentration. Tyrosine 138-141 interleukin 6 Homo sapiens 74-78 20724373-3 2010 The WA treatment (2 and 4 muM) decreased constitutive (MDA-MB-231) and/or IL-6-inducible (MDA-MB-231 and MCF-7) phosphorylation of STAT3 (Tyr(705)) and its upstream regulator Janus-activated kinase 2 (JAK2; Tyr(1007/1008)) in MDA-MB-231, which was accompanied by suppression of their protein levels especially at the higher concentration. Tyrosine 207-210 interleukin 6 Homo sapiens 74-78 20652679-4 2010 RESULTS: AICAR and metformin markedly blunt the IL-6-stimulated expression of SAA cluster genes as well as of haptoglobin in a dose-dependent manner. Metformin 19-28 interleukin 6 Homo sapiens 48-52 21428190-14 2010 There was a negative correlation between cortisol level at 08:00 am and IL-6 (r = -0.45). Hydrocortisone 41-49 interleukin 6 Homo sapiens 72-76 20950383-6 2010 Across the pooled study sample, change in ambulatory activity was significantly correlated with change in interleukin-6 (r = -0.32, P = 0.01) after adjustment for group, age, sex, ethnicity, aspirin and statin medication, baseline body mass index and change in body mass index. Aspirin 191-198 interleukin 6 Homo sapiens 106-119 20950383-7 2010 Change in interleukin-6 was also significantly correlated with change in 2 h glucose after adjustment for the same variables (r = 0.26, P = 0.03). Glucose 77-84 interleukin 6 Homo sapiens 10-23 20882433-9 2010 IL-6 levels were statistically different between each groups and between cases with barium reduction and cases reduced manually by laparotomy within the study group. Barium 84-90 interleukin 6 Homo sapiens 0-4 20728084-8 2010 Levels of IL-6, RANTES, and CRP correlated well with ADP and arachidonic acid (AA)-induced MEA. Adenosine Diphosphate 53-56 interleukin 6 Homo sapiens 10-14 20728084-8 2010 Levels of IL-6, RANTES, and CRP correlated well with ADP and arachidonic acid (AA)-induced MEA. Arachidonic Acid 61-77 interleukin 6 Homo sapiens 10-14 21273686-6 2010 All three biomarkers of inflammation significantly decreased after atorvastatin: CRP from 4.08 +- 3.72 to 2.97 +- 3.26 mug/ml (p < 0.05), IL-6 from 20.66 +- 20.05 to 13.36 +- 11.21 pg/ml (p < 0.05) and MCP-1 from 271.08 +- 85.72 to 213.24 +- 115.09 pg/ml (p < 0.05). Atorvastatin 67-79 interleukin 6 Homo sapiens 141-145 21039738-5 2010 Additionally, we determined whether induction of monocyte NF-kappaB signalling, TNF-alpha and IL-6 production with lipopolysaccharide (LPS), a TLR4 ligand, can be altered with dexamethasone, chloroquine or both. Dexamethasone 176-189 interleukin 6 Homo sapiens 94-98 21039738-7 2010 However, neither dexamethasone nor chloroquine had major influence on TLR4 expression in vitro or suppressed LPS-induced NF-kappaB activation in monocytes, although dexamethasone decreased TNF-alpha and IL-6 production. Dexamethasone 165-178 interleukin 6 Homo sapiens 203-207 20698827-3 2010 In DS-HSF, we found a strong impairment of mitochondrial ATP synthesis due to a reduction in the catalytic efficiency of each of the investigated proteins. Adenosine Triphosphate 57-60 interleukin 6 Homo sapiens 6-9 20698827-5 2010 Interestingly, exposure of DS-HSF to dibutyryl-cAMP, a permanent derivative of cAMP, stimulated ANT, AK and ATPase activities, whereas H89, a specific PKA (protein kinase A) inhibitor, suppressed this cAMPdependent activation, indicating an involvement of the cAMP/PKA-mediated signalling pathway in the ATPase, ANT and AK deficit. Cyclic AMP 47-51 interleukin 6 Homo sapiens 30-33 20698827-5 2010 Interestingly, exposure of DS-HSF to dibutyryl-cAMP, a permanent derivative of cAMP, stimulated ANT, AK and ATPase activities, whereas H89, a specific PKA (protein kinase A) inhibitor, suppressed this cAMPdependent activation, indicating an involvement of the cAMP/PKA-mediated signalling pathway in the ATPase, ANT and AK deficit. Cyclic AMP 79-83 interleukin 6 Homo sapiens 30-33 20698827-6 2010 Consistently, DS-HSF showed decreased basal levels of cAMP and reduced PKA activity. Cyclic AMP 54-58 interleukin 6 Homo sapiens 17-20 20698827-7 2010 Despite the impairment of mitochondrial energy apparatus, no changes in cellular energy status, but increased basal levels of L-lactate, were found in DS-HSF, which partially offset for the mitochondrial energy deficit by increasing glycolysis and mitochondrial mass.These results provide new insight into the molecular basis for mitochondrial dysfunction in DS and might provide a molecular explanation for some clinical features of the syndrome. L-lactate 126-135 interleukin 6 Homo sapiens 154-157 20511664-7 2010 Lipopolysaccharide-treated iron-deficient animals also showed lower liver alpha2m mRNA and reduced serum interleukin-6 and tumor necrosis factor-alpha, suggesting a more generalized effect of iron deficiency. Iron 27-31 interleukin 6 Homo sapiens 105-150 20844194-3 2010 In this study, we report the development of a long-lasting autoactive human mutant TGF-beta1/Fc fusion protein that acts in conjunction with rapamycin to inhibit T cell proliferation and induce the de novo generation of Foxp3(+) Treg in the periphery, while at the same time inhibiting IL-6-mediated Th17 cell differentiation. Sirolimus 141-150 interleukin 6 Homo sapiens 286-290 20939898-6 2010 ISO-1 ((S, R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester), a small-molecule inhibitor of MIF, significantly decreased IL-6, IL-8, and TNF-alpha production in a time- and dose-dependent manner in human peripheral blood cells infected with V. vulnificus. (s, r)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester 7-82 interleukin 6 Homo sapiens 144-148 20727522-9 2010 N-3 supplementation also decreased the lymphocyte, monocyte, TNF-alpha, IL-6 and IL-1beta levels. Nitrogen 0-1 interleukin 6 Homo sapiens 72-76 21034601-9 2010 RESULTS: Y316 blocked TNF production and inhibited the upregulation of TNF mRNA levels in response to LPS, and also prevented the production of IL-1 and IL-6. y316 9-13 interleukin 6 Homo sapiens 153-157 20724602-6 2010 In confluent leukocyte-free term DCs, secreted interleukin-6 levels in incubations with estradiol-17beta were increased 2500-fold by IL-1beta (P < 0.05). Estradiol 88-104 interleukin 6 Homo sapiens 47-60 20693312-7 2010 After 48-h exposure of cells to DXM or BTM, IL-6 caused a significantly greater increase in SP-B mRNA levels (28.1-fold) than IL-6 or glucocorticoids alone. Dexamethasone 32-35 interleukin 6 Homo sapiens 44-48 20693312-7 2010 After 48-h exposure of cells to DXM or BTM, IL-6 caused a significantly greater increase in SP-B mRNA levels (28.1-fold) than IL-6 or glucocorticoids alone. Dexamethasone 32-35 interleukin 6 Homo sapiens 126-130 20693312-8 2010 Whereas IL-6 stimulated tyrosine phosphorylation of STAT3 in a time- and dose-dependent way, DXM and BTM had no effect on STAT3 phosphorylation. Tyrosine 24-32 interleukin 6 Homo sapiens 8-12 20693312-9 2010 Both DXM and BTM could potentiate IL-6-induced phosphorylation of STAT3. Dexamethasone 5-8 interleukin 6 Homo sapiens 34-38 20693312-13 2010 The described in vitro interaction of IL-6 and glucocorticoids could help explain the clinical observation that prenatal inflammation in preterm babies with antenatal steroid administration can attenuate severity of RDS. Steroids 167-174 interleukin 6 Homo sapiens 38-42 20921996-0 2010 Rosiglitazone regulates IL-6-stimulated lipolysis in porcine adipocytes. Rosiglitazone 0-13 interleukin 6 Homo sapiens 24-28 20921996-2 2010 However, the effects of the anti-diabetic drug rosiglitazone on IL-6-stimulated lipolysis and the underlying molecular mechanism are largely unknown. Rosiglitazone 47-60 interleukin 6 Homo sapiens 64-68 20921996-3 2010 In this study, we demonstrated that rosiglitazone suppressed IL-6-stimulated lipolysis in differentiated porcine adipocytes by inactivation of extracellular signal-related kinase (ERK). Rosiglitazone 36-49 interleukin 6 Homo sapiens 61-65 20921996-5 2010 In addition, rosiglitazone significantly reversed IL-6-induced down-regulation of several genes such as perilipin A, peroxisome proliferators activated receptor gamma (PPAR&gamma;), and fatty acid synthetase, as well as the up-regulation of IL-6 mRNA. Rosiglitazone 13-26 interleukin 6 Homo sapiens 50-54 20921996-5 2010 In addition, rosiglitazone significantly reversed IL-6-induced down-regulation of several genes such as perilipin A, peroxisome proliferators activated receptor gamma (PPAR&gamma;), and fatty acid synthetase, as well as the up-regulation of IL-6 mRNA. Rosiglitazone 13-26 interleukin 6 Homo sapiens 245-249 20921996-6 2010 However, mRNA expression of PPAR&gamma; coactivator-1 alpha (PCG-1&alpha;) was enhanced by rosiglitazone in IL-6-stimulated adipocytes. Rosiglitazone 99-112 interleukin 6 Homo sapiens 116-120 20921996-7 2010 These results indicate that rosiglitazone suppresses IL-6-stimulated lipolysis in porcine adipocytes through multiple molecular mechanisms. Rosiglitazone 28-41 interleukin 6 Homo sapiens 53-57 20511664-9 2010 Huh7 cells treated with an iron chelator showed a blunted hepcidin response to interleukin-6, suggesting that the response of hepatic parenchymal cells to inflammatory cytokines may also be iron-dependent. Iron 27-31 interleukin 6 Homo sapiens 79-92 20730705-0 2010 Treatment of polycystic ovary syndrome (PCOS) with metformin ameliorates insulin resistance in parallel with the decrease of serum interleukin-6 concentrations. Metformin 51-60 interleukin 6 Homo sapiens 131-144 20511664-9 2010 Huh7 cells treated with an iron chelator showed a blunted hepcidin response to interleukin-6, suggesting that the response of hepatic parenchymal cells to inflammatory cytokines may also be iron-dependent. Iron 190-194 interleukin 6 Homo sapiens 79-92 20730705-2 2010 We aimed to study if the changes observed in the insulin sensitivity of PCOS patients during treatment with oral contraceptives or metformin associate changes in the serum inflammatory markers interleukin-6 (IL-6) and interleukin-18 (IL-18). Metformin 131-140 interleukin 6 Homo sapiens 193-206 20730705-2 2010 We aimed to study if the changes observed in the insulin sensitivity of PCOS patients during treatment with oral contraceptives or metformin associate changes in the serum inflammatory markers interleukin-6 (IL-6) and interleukin-18 (IL-18). Metformin 131-140 interleukin 6 Homo sapiens 208-212 21103419-7 2010 In circular muscle, PAF causes production of IL-6, and IL-6 causes production of additional H(2)O(2), through activation of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidases. Hydrogen Peroxide 92-100 interleukin 6 Homo sapiens 55-59 20730705-6 2010 PCOS women treated with metformin showed a decrease in IL-6 levels throughout the study compared with women treated with Diane (35) Diario (-33% change vs. +23% change, F=3.709, p=0.048; intention-to-treat analysis: F=5.569, p=0.011). Metformin 24-33 interleukin 6 Homo sapiens 55-59 20730705-8 2010 The decrease in IL-6 levels in women receiving metformin occurred in parallel to the increase in the insulin sensitivity index (r=-0.579, p=0.048; intention-to-treat analysis, r=-0.687, p=0.001). Metformin 47-56 interleukin 6 Homo sapiens 16-20 20730705-9 2010 In conclusion, serum IL-6 levels decreased during treatment with metformin in parallel to amelioration of insulin resistance, whereas oral contraceptives slightly increased circulating IL-6 levels without changing insulin sensitivity. Metformin 65-74 interleukin 6 Homo sapiens 21-25 21122279-0 2010 Montelukast reduces eosinophilic inflammation by inhibiting both epithelial cell cytokine secretion (GM-CSF, IL-6, IL-8) and eosinophil survival. montelukast 0-11 interleukin 6 Homo sapiens 109-113 20731619-10 2010 Inactivation of ERK signaling pathways by PD98059 effectively blocked IL-6, -8, and -10 induction by WTC2.5; the p38 kinase inhibitor SB203580 significantly decreased induction of IL-8 and -10. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 42-49 interleukin 6 Homo sapiens 70-74 21174772-7 2010 TSSN treatment significantly attenuated mRNA of inflammatory mediators such as COX-2, IL-1beta, IL-6 while increased PPAR-gamma gene and protein expression. tssn 0-4 interleukin 6 Homo sapiens 96-100 20170929-6 2010 Plasma IL-1beta and IL-6 levels in nonoverweight subjects were positively and strongly associated with fasting blood glucose and hemoglobin A(1c); in contrast, these cytokines were strongly associated with homeostasis model assessment of insulin resistance and fasting glucose in overweight subjects. Glucose 117-124 interleukin 6 Homo sapiens 20-24 20170929-6 2010 Plasma IL-1beta and IL-6 levels in nonoverweight subjects were positively and strongly associated with fasting blood glucose and hemoglobin A(1c); in contrast, these cytokines were strongly associated with homeostasis model assessment of insulin resistance and fasting glucose in overweight subjects. Glucose 269-276 interleukin 6 Homo sapiens 20-24 20379953-3 2010 Inhibition of MEK significantly blocked the effects of kansuinine A and B on IL-6-induced Stat3 activation and tyrosine phosphorylation. Tyrosine 111-119 interleukin 6 Homo sapiens 77-81 20379953-4 2010 These results suggest that blocking of IL-6-induced signal transduction is partially due to the sustained activation of ERK1/2 by kansuinine A and B, which in turn results in an increase of Stat3 serine phosphorylation and SOCS-3 expression. Serine 196-202 interleukin 6 Homo sapiens 39-43 20736797-11 2010 In addition to its effect on cellular membrane, P188 affects stress-related p38 signaling, apoptosis-related GSK3, and inflammation-related IL-6 signaling. 1,3-BIS(TERT-BUTYLPEROXYISOPROPYL)BENZENE 48-52 interleukin 6 Homo sapiens 140-144 20728433-0 2010 Identification of BCAP-(L) as a negative regulator of the TLR signaling-induced production of IL-6 and IL-10 in macrophages by tyrosine phosphoproteomics. Tyrosine 127-135 interleukin 6 Homo sapiens 94-98 21031020-0 2010 Subtoxic levels hydrogen peroxide-induced production of interleukin-6 by retinal pigment epithelial cells. Hydrogen Peroxide 16-33 interleukin 6 Homo sapiens 56-69 21031020-1 2010 PURPOSE: To study the effect of subtoxic levels of hydrogen peroxide (H(2)O(2)) on the expression and release of interleukin-6 (IL-6) by cultured retinal pigment epithelial (RPE) cells and to explore the relevant signal pathways. Hydrogen Peroxide 51-68 interleukin 6 Homo sapiens 113-126 21031020-1 2010 PURPOSE: To study the effect of subtoxic levels of hydrogen peroxide (H(2)O(2)) on the expression and release of interleukin-6 (IL-6) by cultured retinal pigment epithelial (RPE) cells and to explore the relevant signal pathways. Hydrogen Peroxide 51-68 interleukin 6 Homo sapiens 128-132 21031020-7 2010 RESULTS: Subtoxic levels of H(2)O(2) (100 microM and less) increased the IL-6 mRNA level and the release of IL-6 protein by the cultured human RPE cells in a dose- and time-dependent manner. Hydrogen Peroxide 28-36 interleukin 6 Homo sapiens 73-77 21031020-7 2010 RESULTS: Subtoxic levels of H(2)O(2) (100 microM and less) increased the IL-6 mRNA level and the release of IL-6 protein by the cultured human RPE cells in a dose- and time-dependent manner. Hydrogen Peroxide 28-36 interleukin 6 Homo sapiens 108-112 21031020-9 2010 The NF-kappaB inhibitor decreased the H(2)O(2)-induced expression of IL-6. Hydrogen Peroxide 38-46 interleukin 6 Homo sapiens 69-73 21031020-10 2010 The p38 inhibitor, but not the ERK or JNK inhibitor, completely abolished H(2)O(2)-induced expression of IL-6 by RPE cells. Hydrogen Peroxide 74-82 interleukin 6 Homo sapiens 105-109 20416859-10 2010 Anti-IL6 seem to increase total and LDL-cholesterol; however these changes are associated with an improvement in the TC/HDL-C ratio. Cholesterol 40-51 interleukin 6 Homo sapiens 5-8 20236757-0 2010 Autocrine production of interleukin-6 confers cisplatin and paclitaxel resistance in ovarian cancer cells. Cisplatin 46-55 interleukin 6 Homo sapiens 24-37 20236757-0 2010 Autocrine production of interleukin-6 confers cisplatin and paclitaxel resistance in ovarian cancer cells. Paclitaxel 60-70 interleukin 6 Homo sapiens 24-37 20236757-3 2010 Here we demonstrate that both exogenous (a relatively short period of treatment with recombination IL-6) and endogenous IL-6 (by transfecting with plasmid encoding for sense IL-6) induce cisplatin and paclitaxel resistance in non-IL-6-expressing A2780 cells, while deleting of endogenous IL-6 expression in IL-6-overexpressing SKOV3 cells (by transfecting with plasmid encoding for antisense IL-6) promotes the sensitivity of these cells to anticancer drugs. Cisplatin 187-196 interleukin 6 Homo sapiens 99-103 20236757-3 2010 Here we demonstrate that both exogenous (a relatively short period of treatment with recombination IL-6) and endogenous IL-6 (by transfecting with plasmid encoding for sense IL-6) induce cisplatin and paclitaxel resistance in non-IL-6-expressing A2780 cells, while deleting of endogenous IL-6 expression in IL-6-overexpressing SKOV3 cells (by transfecting with plasmid encoding for antisense IL-6) promotes the sensitivity of these cells to anticancer drugs. Cisplatin 187-196 interleukin 6 Homo sapiens 120-124 20236757-3 2010 Here we demonstrate that both exogenous (a relatively short period of treatment with recombination IL-6) and endogenous IL-6 (by transfecting with plasmid encoding for sense IL-6) induce cisplatin and paclitaxel resistance in non-IL-6-expressing A2780 cells, while deleting of endogenous IL-6 expression in IL-6-overexpressing SKOV3 cells (by transfecting with plasmid encoding for antisense IL-6) promotes the sensitivity of these cells to anticancer drugs. Cisplatin 187-196 interleukin 6 Homo sapiens 120-124 20236757-3 2010 Here we demonstrate that both exogenous (a relatively short period of treatment with recombination IL-6) and endogenous IL-6 (by transfecting with plasmid encoding for sense IL-6) induce cisplatin and paclitaxel resistance in non-IL-6-expressing A2780 cells, while deleting of endogenous IL-6 expression in IL-6-overexpressing SKOV3 cells (by transfecting with plasmid encoding for antisense IL-6) promotes the sensitivity of these cells to anticancer drugs. Cisplatin 187-196 interleukin 6 Homo sapiens 120-124 20236757-3 2010 Here we demonstrate that both exogenous (a relatively short period of treatment with recombination IL-6) and endogenous IL-6 (by transfecting with plasmid encoding for sense IL-6) induce cisplatin and paclitaxel resistance in non-IL-6-expressing A2780 cells, while deleting of endogenous IL-6 expression in IL-6-overexpressing SKOV3 cells (by transfecting with plasmid encoding for antisense IL-6) promotes the sensitivity of these cells to anticancer drugs. Cisplatin 187-196 interleukin 6 Homo sapiens 120-124 20236757-3 2010 Here we demonstrate that both exogenous (a relatively short period of treatment with recombination IL-6) and endogenous IL-6 (by transfecting with plasmid encoding for sense IL-6) induce cisplatin and paclitaxel resistance in non-IL-6-expressing A2780 cells, while deleting of endogenous IL-6 expression in IL-6-overexpressing SKOV3 cells (by transfecting with plasmid encoding for antisense IL-6) promotes the sensitivity of these cells to anticancer drugs. Cisplatin 187-196 interleukin 6 Homo sapiens 120-124 20236757-3 2010 Here we demonstrate that both exogenous (a relatively short period of treatment with recombination IL-6) and endogenous IL-6 (by transfecting with plasmid encoding for sense IL-6) induce cisplatin and paclitaxel resistance in non-IL-6-expressing A2780 cells, while deleting of endogenous IL-6 expression in IL-6-overexpressing SKOV3 cells (by transfecting with plasmid encoding for antisense IL-6) promotes the sensitivity of these cells to anticancer drugs. Cisplatin 187-196 interleukin 6 Homo sapiens 120-124 20236757-3 2010 Here we demonstrate that both exogenous (a relatively short period of treatment with recombination IL-6) and endogenous IL-6 (by transfecting with plasmid encoding for sense IL-6) induce cisplatin and paclitaxel resistance in non-IL-6-expressing A2780 cells, while deleting of endogenous IL-6 expression in IL-6-overexpressing SKOV3 cells (by transfecting with plasmid encoding for antisense IL-6) promotes the sensitivity of these cells to anticancer drugs. Paclitaxel 201-211 interleukin 6 Homo sapiens 99-103 20236757-3 2010 Here we demonstrate that both exogenous (a relatively short period of treatment with recombination IL-6) and endogenous IL-6 (by transfecting with plasmid encoding for sense IL-6) induce cisplatin and paclitaxel resistance in non-IL-6-expressing A2780 cells, while deleting of endogenous IL-6 expression in IL-6-overexpressing SKOV3 cells (by transfecting with plasmid encoding for antisense IL-6) promotes the sensitivity of these cells to anticancer drugs. Paclitaxel 201-211 interleukin 6 Homo sapiens 120-124 20236757-3 2010 Here we demonstrate that both exogenous (a relatively short period of treatment with recombination IL-6) and endogenous IL-6 (by transfecting with plasmid encoding for sense IL-6) induce cisplatin and paclitaxel resistance in non-IL-6-expressing A2780 cells, while deleting of endogenous IL-6 expression in IL-6-overexpressing SKOV3 cells (by transfecting with plasmid encoding for antisense IL-6) promotes the sensitivity of these cells to anticancer drugs. Paclitaxel 201-211 interleukin 6 Homo sapiens 120-124 20236757-3 2010 Here we demonstrate that both exogenous (a relatively short period of treatment with recombination IL-6) and endogenous IL-6 (by transfecting with plasmid encoding for sense IL-6) induce cisplatin and paclitaxel resistance in non-IL-6-expressing A2780 cells, while deleting of endogenous IL-6 expression in IL-6-overexpressing SKOV3 cells (by transfecting with plasmid encoding for antisense IL-6) promotes the sensitivity of these cells to anticancer drugs. Paclitaxel 201-211 interleukin 6 Homo sapiens 120-124 20236757-3 2010 Here we demonstrate that both exogenous (a relatively short period of treatment with recombination IL-6) and endogenous IL-6 (by transfecting with plasmid encoding for sense IL-6) induce cisplatin and paclitaxel resistance in non-IL-6-expressing A2780 cells, while deleting of endogenous IL-6 expression in IL-6-overexpressing SKOV3 cells (by transfecting with plasmid encoding for antisense IL-6) promotes the sensitivity of these cells to anticancer drugs. Paclitaxel 201-211 interleukin 6 Homo sapiens 120-124 20236757-3 2010 Here we demonstrate that both exogenous (a relatively short period of treatment with recombination IL-6) and endogenous IL-6 (by transfecting with plasmid encoding for sense IL-6) induce cisplatin and paclitaxel resistance in non-IL-6-expressing A2780 cells, while deleting of endogenous IL-6 expression in IL-6-overexpressing SKOV3 cells (by transfecting with plasmid encoding for antisense IL-6) promotes the sensitivity of these cells to anticancer drugs. Paclitaxel 201-211 interleukin 6 Homo sapiens 120-124 20236757-3 2010 Here we demonstrate that both exogenous (a relatively short period of treatment with recombination IL-6) and endogenous IL-6 (by transfecting with plasmid encoding for sense IL-6) induce cisplatin and paclitaxel resistance in non-IL-6-expressing A2780 cells, while deleting of endogenous IL-6 expression in IL-6-overexpressing SKOV3 cells (by transfecting with plasmid encoding for antisense IL-6) promotes the sensitivity of these cells to anticancer drugs. Paclitaxel 201-211 interleukin 6 Homo sapiens 120-124 20538801-4 2010 WPBs could also contain tPA, and in IL-1beta-treated cells, IL-8, IL-6, MCP-1, and GRO-alpha, and were the primary source for histamine or ionomycin-stimulated secretion of these molecules. Ionomycin 139-148 interleukin 6 Homo sapiens 66-70 21031020-12 2010 CONCLUSIONS: H(2)O(2) stimulated the production of IL-6, a key factor in the modulation of immune responses, inflammatory processes, and the occurrence of autoimmune diseases, which recently has been documented to be increased in age-related macular degeneration (AMD). Hydrogen Peroxide 13-21 interleukin 6 Homo sapiens 51-55 20823594-9 2010 The results of all parameters indicate that microspheres containing atorvastatin calcium were capable of improving functional outcome, attenuating the expression of TNF-alpha, IL-1beta and IL-6; lowering lipid peroxidation levels and maintaining the preservation of the cellular uniformity. Atorvastatin 68-88 interleukin 6 Homo sapiens 189-193 20545708-7 2010 The expression of IL-6 in response to IL-17A and F and dexamethasone was determined by Q-RT-PCR using primary airway epithelial cells from normal and asthmatic subjects. Dexamethasone 55-68 interleukin 6 Homo sapiens 18-22 20545708-13 2010 Dexamethasone significantly decreased the IL-17-induced IL-6 expression in cells from normal individuals but not in those from asthmatics (P< or =0.05). Dexamethasone 0-13 interleukin 6 Homo sapiens 56-60 20816188-9 2010 After ozone exposure, atopic asthmatic subjects had significantly increased sputum IL-6 and IL-1beta levels and airway macrophage Toll-like receptor 4, Fc(epsilon)RI, and CD23 expression; values in healthy volunteers and atopic nonasthmatic subjects showed no significant change. Ozone 6-11 interleukin 6 Homo sapiens 83-87 20435648-3 2010 Monocytes exposed to vitamin D(3) for 48 h were then stimulated with a TLR9 agonist for a further 24 h. The level of IL-6 secretion was measured by ELISA. Vitamin D 21-30 interleukin 6 Homo sapiens 117-121 20600219-3 2010 Cultured human lung fibroblasts (HLF) were used to determine whether various protein kinase pathways were involved in the release of IL-6 following combined exposure to the PM-derived metal, Ni, and M. fermentans-derived macrophage-activating lipopeptide 2 (MALP-2), a toll-like receptor 2 agonist. Metals 184-189 interleukin 6 Homo sapiens 133-137 20562100-4 2010 Here we reported that IL-6 promoted survival of human liver cancer cells through activating STAT3 in response to doxorubicin treatment. Doxorubicin 113-124 interleukin 6 Homo sapiens 22-26 20562100-7 2010 Addition of IL-6 induced STAT3 activation in Hep3B cells and led to protection against doxorubicin. Doxorubicin 87-98 interleukin 6 Homo sapiens 12-16 20562100-8 2010 In contrast, neutralizing IL-6 with anti-IL-6 antibody decreased survival of SNU-449 cells in response to doxorubicin. Doxorubicin 106-117 interleukin 6 Homo sapiens 26-30 20562100-8 2010 In contrast, neutralizing IL-6 with anti-IL-6 antibody decreased survival of SNU-449 cells in response to doxorubicin. Doxorubicin 106-117 interleukin 6 Homo sapiens 41-45 20562100-10 2010 Targeting STAT3 with STAT3 siRNA reduced the protection of IL-6 against doxorubicin-induced apoptosis, indicating that STAT3 signaling contributed to the anti-apoptotic effect of IL-6. Doxorubicin 72-83 interleukin 6 Homo sapiens 59-63 20562100-10 2010 Targeting STAT3 with STAT3 siRNA reduced the protection of IL-6 against doxorubicin-induced apoptosis, indicating that STAT3 signaling contributed to the anti-apoptotic effect of IL-6. Doxorubicin 72-83 interleukin 6 Homo sapiens 179-183 20562100-13 2010 Finally, neutralization of endogenous IL-6 with anti-IL-6 antibody or blockade of STAT3 with LLL12 lowered the recovery in SNU-449 cells after doxorubicin treatment. Doxorubicin 143-154 interleukin 6 Homo sapiens 38-42 20725112-6 2010 In the HBF group, a positive correlation was observed between TNF-&alpha; and IL-6, IL-10 and the proinflammatory cytokines, and IL-6 and glycemia. Adenosine Monophosphate 67-70 interleukin 6 Homo sapiens 82-86 20725112-7 2010 In the OW group, a positive correlation was found between IL-6 and triglycerides. Triglycerides 67-80 interleukin 6 Homo sapiens 58-62 20512034-11 2010 Phosphorylation levels induced by interleukin-6 in STAT1 and STAT3 and by combination of phorbol 12-myristate 13-acetate and calcium ionophore A23187 in extracellular signal-regulated kinases 1/2, members of a mitogen-activated protein kinase family, were depressed in patients" monocytes, whereas phosphorylation levels induced by granulocyte-macrophage colony-stimulating factor in STAT5 was normal. Tetradecanoylphorbol Acetate 89-120 interleukin 6 Homo sapiens 34-47 20546720-3 2010 We demonstrate that 17beta-estradiol and HM-D, a novel selective estrogen receptor modulator compound, clearly reduced the IL-6 expression levels after lipopolysaccharide exposure in ARPE-19 cells. Estradiol 20-36 interleukin 6 Homo sapiens 123-127 20511231-4 2010 We have demonstrated that multiple nonresponsive tumor lines are able to undergo synergistic induction of IL6 following combinatorial treatment with IL1beta and the AHR agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin. Polychlorinated Dibenzodioxins 177-212 interleukin 6 Homo sapiens 106-109 20682658-0 2010 Cisplatin treatment induces a transient increase in tumorigenic potential associated with high interleukin-6 expression in head and neck squamous cell carcinoma. Cisplatin 0-9 interleukin 6 Homo sapiens 95-108 20682658-7 2010 Preliminary functional assessment of a gene, interleukin-6 (IL-6), highly upregulated in cisplatin-treated cells was carried out using clonogenicity and tumorigenicity assays. Cisplatin 89-98 interleukin 6 Homo sapiens 45-58 20682658-7 2010 Preliminary functional assessment of a gene, interleukin-6 (IL-6), highly upregulated in cisplatin-treated cells was carried out using clonogenicity and tumorigenicity assays. Cisplatin 89-98 interleukin 6 Homo sapiens 60-64 20682658-8 2010 We show that cisplatin-induced IL-6 expression can contribute to the increase in tumorigenic potential of head and neck cancer cells but does not contribute to cisplatin resistance. Cisplatin 13-22 interleukin 6 Homo sapiens 31-35 20682658-9 2010 Finally, through clonal analysis, we show that cisplatin-induced IL-6 expression and cisplatin-induced tumorigenicity are stochastically derived. Cisplatin 47-56 interleukin 6 Homo sapiens 65-69 20682658-10 2010 We report that cisplatin treatment of head and neck cancer cells results in a transient accumulation of cisplatin-resistant, small, and IL-6-positive cells that are highly tumorigenic. Cisplatin 15-24 interleukin 6 Homo sapiens 136-140 20435648-6 2010 TLR9-induced IL-6 production was impaired in monocytes treated with vitamin D(3) compared with untreated cells. Vitamin D 68-77 interleukin 6 Homo sapiens 13-17 20599720-8 2010 BAPTA/AM abolished LPS-induced TNFalpha and IL-6 production, while EGTA only partially suppressed LPS-induced IL-6 production, but not TNFalpha production. Egtazic Acid 67-71 interleukin 6 Homo sapiens 110-114 20578705-8 2010 Incubation of ARPE-19 cells with 33 mM glucose for 9 days significantly induced the accumulation of VEGF, IL-6, IL-8, TGF-beta, and COX-2, activation of PKCbeta, and reduction of Cx43 and GJIC. Glucose 39-46 interleukin 6 Homo sapiens 106-110 20578705-9 2010 Incubation of ARPE-19 cells with 33 mM glucose in the presence of 0-10 microM trans-resveratrol dose-dependently inhibited VEGF, TGF-beta1, COX-2, IL-6, and IL-8 accumulation, PKCbeta activation, and Cx43 degradation and enhanced GJIC. Glucose 39-46 interleukin 6 Homo sapiens 147-151 20578705-9 2010 Incubation of ARPE-19 cells with 33 mM glucose in the presence of 0-10 microM trans-resveratrol dose-dependently inhibited VEGF, TGF-beta1, COX-2, IL-6, and IL-8 accumulation, PKCbeta activation, and Cx43 degradation and enhanced GJIC. Resveratrol 78-95 interleukin 6 Homo sapiens 147-151 20845101-11 2010 Dexamethasone significantly reduced postoperative levels of CRP (p = 0.01), IL-6 and IL-1 (p < 0.05), fatigue (p = 0.01) and overall pain during the first 24 postoperative hours (p < 0.05) and the total requirement of analgesic (ketorolac) (p < 0.05). Dexamethasone 0-13 interleukin 6 Homo sapiens 76-80 20430366-2 2010 The present study was conducted to assess the association between IL-6 (-174 G/C) gene polymorphism and GO in renal transplant recipients under cyclosporine (CsA), tacrolimus (Tcr), or sirolimus (Sir)-based regimens. Cyclosporine 144-156 interleukin 6 Homo sapiens 66-70 20463039-10 2010 Furthermore, resveratrol down-regulated the expression and secretion of interleukin-6 and interleukin-8. Resveratrol 13-24 interleukin 6 Homo sapiens 72-85 20430366-2 2010 The present study was conducted to assess the association between IL-6 (-174 G/C) gene polymorphism and GO in renal transplant recipients under cyclosporine (CsA), tacrolimus (Tcr), or sirolimus (Sir)-based regimens. Cyclosporine 158-161 interleukin 6 Homo sapiens 66-70 20430366-2 2010 The present study was conducted to assess the association between IL-6 (-174 G/C) gene polymorphism and GO in renal transplant recipients under cyclosporine (CsA), tacrolimus (Tcr), or sirolimus (Sir)-based regimens. Sirolimus 185-194 interleukin 6 Homo sapiens 66-70 20430640-5 2010 To reduce non-specific binding, a mixed self-assembled monolayer of mercaptoundecanoic acid (MUA) and mercaptohexanol (MCH) was attached to the sensor, and then used for IL-6 determination using a sandwich type immunoassay. 9-Methyluric acid 93-96 interleukin 6 Homo sapiens 170-174 20206688-2 2010 The NF-kappaB-dependent gene expression of IL8, IL6, PTGS2/COX2, TNF and IL33 in directly irradiated human skin fibroblasts produced the cytokines and prostaglandin E2 (PGE2) with autocrine/paracrine functions, which further activated signaling pathways and induced NF-kappaB-dependent gene expression in bystander cells. Dinoprostone 151-167 interleukin 6 Homo sapiens 48-51 20430640-5 2010 To reduce non-specific binding, a mixed self-assembled monolayer of mercaptoundecanoic acid (MUA) and mercaptohexanol (MCH) was attached to the sensor, and then used for IL-6 determination using a sandwich type immunoassay. mch 119-122 interleukin 6 Homo sapiens 170-174 20228251-1 2010 Oxidative stress induced by inhibition of glutathione (GSH) biosynthesis with D,L-buthionine-S,R-sulfoximine (BSO) causes human microglia, human astrocytes, THP-1 cells, and U373 cells to secrete materials toxic to human neuroblastoma SH-SY5Y cells and stimulates them to release TNF-alpha, IL-6, and nitrite ions. Glutathione 55-58 interleukin 6 Homo sapiens 291-295 20403460-3 2010 Myricetin significantly decreased IL-1beta-induced production of IL-6 and MMP-1 in synovial cells. myricetin 0-9 interleukin 6 Homo sapiens 65-69 20403460-5 2010 These results suggest that myricetin reduces the production of MMP and IL-6 in SW982 cells by inhibiting MAPKs (JNK and p38). myricetin 27-36 interleukin 6 Homo sapiens 71-75 21055228-9 2010 Bile acids can change tumor cell viability via IL-6 pathway. Bile Acids and Salts 0-10 interleukin 6 Homo sapiens 47-51 20499049-0 2010 Expression of TNF-alpha and IL-6 in HMC-1 cells treated with bisphenol A is attenuated by plant-originating glycoprotein (75 kDa) by blocking p38 MAPK. bisphenol A 61-72 interleukin 6 Homo sapiens 28-32 19844976-6 2010 Furthermore, cobalt, molybdenum ions, and Co-Cr-Mo alloy particles similarly induce elevated secretion of IL-1beta, TNFalpha, and IL-6. Molybdenum 21-31 interleukin 6 Homo sapiens 130-134 21055228-0 2010 [Effects of bile acids on expression of interleukin-6 and cell viability in QBC939 cell line]. Bile Acids and Salts 12-22 interleukin 6 Homo sapiens 40-53 21055228-1 2010 OBJECTIVE: To research the effects of bile acids on the expression of interleukin-6 (IL-6) and the cell viability in QBC939 cell line. Bile Acids and Salts 38-48 interleukin 6 Homo sapiens 70-83 21055228-1 2010 OBJECTIVE: To research the effects of bile acids on the expression of interleukin-6 (IL-6) and the cell viability in QBC939 cell line. Bile Acids and Salts 38-48 interleukin 6 Homo sapiens 85-89 21055228-8 2010 CONCLUSIONS: Free bile acids (CA, DCA and CDCA) can inhibit the expression of IL-6 and the cell viability, while glycine conjugates (GCA, GDCA and GCDCA) can promote the expression of IL-6 and the cell viability. Bile Acids and Salts 18-28 interleukin 6 Homo sapiens 78-82 21055228-8 2010 CONCLUSIONS: Free bile acids (CA, DCA and CDCA) can inhibit the expression of IL-6 and the cell viability, while glycine conjugates (GCA, GDCA and GCDCA) can promote the expression of IL-6 and the cell viability. Glycine 113-120 interleukin 6 Homo sapiens 184-188 20564181-8 2010 In this context, we observed induction of MCP-2 and IL-6 by morphine. Morphine 60-68 interleukin 6 Homo sapiens 52-56 20618689-10 2010 The modest upregulation of IL-8 and IL-6 might be associated with the milder clinical manifestations of PCP in AIDS patients. pcp 104-107 interleukin 6 Homo sapiens 36-40 20451499-4 2010 Thrombin activated Akt, PKC and MAPK in HAoSMC, and thrombin-mediated expression of IL-6 and CXCL8 was significantly inhibited by LY294002, AKT IV, RO318220, and GF109203X as well as by diphenyleneiodium at the messenger RNA and the protein levels. Ro 31-8220 148-156 interleukin 6 Homo sapiens 84-88 20484173-0 2010 Interleukin-6 as a potential indicator for prevention of high-risk adenoma recurrence by dietary flavonols in the polyp prevention trial. Flavonols 97-106 interleukin 6 Homo sapiens 0-13 20383201-7 2010 AR phosphorylation at Tyr-534 was induced by treatment with EGF, IL-6 or bombesin, but not by heregulin or Gas6. Tyrosine 22-25 interleukin 6 Homo sapiens 65-69 20457835-0 2010 Prostaglandin E2 induces interleukin-6 expression in human chondrocytes via cAMP/protein kinase A- and phosphatidylinositol 3-kinase-dependent NF-kappaB activation. Dinoprostone 0-16 interleukin 6 Homo sapiens 25-38 20457835-3 2010 Although PGE(2) stimulates IL-6 expression in human chondrocytes, the underlying signaling pathway of this process has yet to be delineated. Dinoprostone 9-15 interleukin 6 Homo sapiens 27-31 20457835-5 2010 PGE(2) induces IL-6 mRNA and protein expression via a cAMP-dependent pathway, reaching maximal levels after 60 min of stimulation before declining to baseline levels at 6 h. Forskolin, an adenylyl cyclase activator, also stimulates IL-6 expression in human chondrocytes in a dose- and time-dependent fashion. Cyclic AMP 54-58 interleukin 6 Homo sapiens 15-19 20457835-5 2010 PGE(2) induces IL-6 mRNA and protein expression via a cAMP-dependent pathway, reaching maximal levels after 60 min of stimulation before declining to baseline levels at 6 h. Forskolin, an adenylyl cyclase activator, also stimulates IL-6 expression in human chondrocytes in a dose- and time-dependent fashion. Cyclic AMP 54-58 interleukin 6 Homo sapiens 232-236 20457835-6 2010 Inhibition of downstream effectors of cAMP activity such as protein kinase A (PKA) or phosphatidylinositol 3 kinase (PI3K) blocks PGE(2)- and forskolin-induced IL-6 upregulation. Cyclic AMP 38-42 interleukin 6 Homo sapiens 160-164 20457835-9 2010 p65 knockdown completely abrogates IL-6 mRNA synthesis in PGE(2)- and forskolin-primed chondrocytes. Dinoprostone 58-64 interleukin 6 Homo sapiens 35-39 20457835-10 2010 Cumulatively, our data show that PGE(2) and forskolin induce IL-6 expression in human chondrocytes via cAMP/PKA and PI3K-dependent pathways, which in turn regulate the activation and binding of p65 to the IL-6 promoter. Cyclic AMP 103-107 interleukin 6 Homo sapiens 61-65 20383201-8 2010 Small interfering RNA-mediated knockdown of Ack1 or Src showed that Ack1 mediates heregulin- and Gas6-induced AR Tyr-267 phosphorylation, whereas Src mediates Tyr-534 phosphorylation induced by EGF, IL-6 and bombesin. Tyrosine 113-116 interleukin 6 Homo sapiens 199-203 20383201-8 2010 Small interfering RNA-mediated knockdown of Ack1 or Src showed that Ack1 mediates heregulin- and Gas6-induced AR Tyr-267 phosphorylation, whereas Src mediates Tyr-534 phosphorylation induced by EGF, IL-6 and bombesin. Tyrosine 159-162 interleukin 6 Homo sapiens 199-203 20607488-3 2010 This study showed that ethanol extract of AJK interestingly suppressed the production and mRNA expression of TNF-alpha, IL-6 and IL-8, as important inflammatory cytokines. Ethanol 23-30 interleukin 6 Homo sapiens 120-124 20484173-3 2010 We estimated odds ratios and 95% confidence intervals (95% CI) to determine whether serum IL-6 was associated with colorectal adenoma recurrence and flavonol intake and thus may serve as a risk indicator and as a response indicator to dietary flavonols. Flavonols 243-252 interleukin 6 Homo sapiens 90-94 20484173-5 2010 Intake of flavonols, especially of isorhamnetin, kaempferol, and quercetin, was inversely associated with serum IL-6 concentrations (highest versus lowest flavonol intake quartile, 1.80 versus 2.20 pg/mL) and high-risk (OR, 0.51; 95% CI, 0.26-0.98) and advanced adenoma recurrence (OR, 0.17; 95% CI, 0.06-0.50). Flavonols 10-19 interleukin 6 Homo sapiens 112-116 20484173-8 2010 Our results suggest that serum IL-6 may serve as a risk indicator and as a response indicator to dietary flavonols for colorectal cancer prevention. Flavonols 105-114 interleukin 6 Homo sapiens 31-35 19428234-10 2010 Moreover, tryptophan reduced the expression of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin (IL)-6, interferon (IFN)-gamma, IL-12p40, IL-1beta and IL-17, as well as IL-8 and intracellular adhesion molecule-1, and resulted in increased expression of apoptosis initiators caspase-8 and Bax. Tryptophan 10-20 interleukin 6 Homo sapiens 107-125 20445007-10 2010 In contrast, delayed DEX addition significantly suppressed PAM-induced IL-1beta, IL-6, or IL-8 and also suppressed LPS-induced IL-1beta and IL-8. Dexamethasone 21-24 interleukin 6 Homo sapiens 81-85 20231081-6 2010 Compared to vehicle-treated cells, all antidepressants inhibited dexamethasone (DEX, 10-100nM) inhibition of LPS-stimulated IL-6 levels (p values ranging from 0.007 to 0.1). Dexamethasone 65-78 interleukin 6 Homo sapiens 124-128 20231081-6 2010 Compared to vehicle-treated cells, all antidepressants inhibited dexamethasone (DEX, 10-100nM) inhibition of LPS-stimulated IL-6 levels (p values ranging from 0.007 to 0.1). Dexamethasone 80-83 interleukin 6 Homo sapiens 124-128 20091087-0 2010 Geniposide inhibits interleukin-6 and interleukin-8 production in lipopolysaccharide-induced human umbilical vein endothelial cells by blocking p38 and ERK1/2 signaling pathways. geniposide 0-10 interleukin 6 Homo sapiens 20-33 20091087-1 2010 OBJECTIVE: The aim of this study was to investigate the inhibitory effect of geniposide on lipopolysaccharide (LPS)-induced interleukin-6 (IL-6) and interleukin-8 (IL-8) production in human umbilical vein endothelial cells (HUVECs). geniposide 77-87 interleukin 6 Homo sapiens 124-137 20091087-1 2010 OBJECTIVE: The aim of this study was to investigate the inhibitory effect of geniposide on lipopolysaccharide (LPS)-induced interleukin-6 (IL-6) and interleukin-8 (IL-8) production in human umbilical vein endothelial cells (HUVECs). geniposide 77-87 interleukin 6 Homo sapiens 139-143 20091087-6 2010 RESULTS: Geniposide effectively inhibited LPS-induced expression of IL-6 and IL-8 in HUVECs at the transcription and translation levels. geniposide 9-19 interleukin 6 Homo sapiens 68-72 20091087-9 2010 CONCLUSION: The results show that geniposide can inhibit LPS-induced IL-6 and IL-8 production in HUVECs by blocking p38 MAPK and ERK1/2 signaling pathways. geniposide 34-44 interleukin 6 Homo sapiens 69-73 20130591-7 2010 By means of chemical inhibitors of known signaling pathways, we showed that ERK1/2, the p38-, JNK-, PI3K/AKT-, STAT3-, and IL-6 as well as the calcium-mediated signaling pathways, are functionally involved in the IRA gene response and that a major part of it is triggered by mitochondrial and, to a lesser extent, non-mitochondrial production of reactive oxygen species. Reactive Oxygen Species 346-369 interleukin 6 Homo sapiens 123-127 20145198-6 2010 Moreover, the addition of NAC, a scavenger of ROS, abrogated the rVpr-induced formation of OxPC, the phosphorylation of C/EBP-beta, a substrate of MAPK, and IL-6 production. ros 46-49 interleukin 6 Homo sapiens 157-161 20232292-8 2010 Ethanol-exposed macrophages developed enhanced interleukin 6 (IL6), IL8, and tumor necrosis factor alpha responses to lipopolysaccharide with time-dependent increases in histone acetylation that could be prevented by inhibition of ethanol metabolism. Ethanol 0-7 interleukin 6 Homo sapiens 47-60 20232292-8 2010 Ethanol-exposed macrophages developed enhanced interleukin 6 (IL6), IL8, and tumor necrosis factor alpha responses to lipopolysaccharide with time-dependent increases in histone acetylation that could be prevented by inhibition of ethanol metabolism. Ethanol 0-7 interleukin 6 Homo sapiens 62-65 23675187-4 2010 In addition, N-acetyl cysteine, a scavenger of reactive oxygen species, inhibits activation of NF-kappaB and induction of interleukin-6 by tumor necrosis factor alpha, being ineffective on interleukin-1 beta activity. Acetylcysteine 13-30 interleukin 6 Homo sapiens 122-135 23675187-4 2010 In addition, N-acetyl cysteine, a scavenger of reactive oxygen species, inhibits activation of NF-kappaB and induction of interleukin-6 by tumor necrosis factor alpha, being ineffective on interleukin-1 beta activity. Reactive Oxygen Species 47-70 interleukin 6 Homo sapiens 122-135 20220107-0 2010 Nicotine suppresses interleukin-6 production from vascular endothelial cells: a possible therapeutic role of nicotine for preeclampsia. Nicotine 0-8 interleukin 6 Homo sapiens 20-33 20585296-10 2010 There was significant difference in serum IL-6 between two groups in 8 h and 24 h after exercise (P<0.05) and it was greater in carbohydrate group. Carbohydrates 131-143 interleukin 6 Homo sapiens 42-46 20585296-12 2010 CONCLUSION: According to results, carbohydrate increased the inflammatory (IL-6) response following resistance exercise, but had no effects on CRP and CK. Carbohydrates 34-46 interleukin 6 Homo sapiens 75-79 20220107-0 2010 Nicotine suppresses interleukin-6 production from vascular endothelial cells: a possible therapeutic role of nicotine for preeclampsia. Nicotine 109-117 interleukin 6 Homo sapiens 20-33 20220107-7 2010 Nicotine significantly preserved cell survival and suppressed IL-6 production from endothelial cells. Nicotine 0-8 interleukin 6 Homo sapiens 62-66 20406921-2 2010 Because interleukin-6 (IL-6) induces expression of hepcidin, one of the principal regulators of iron metabolism, we studied the contribution of hepcidin in anemia in HL at diagnosis. Iron 96-100 interleukin 6 Homo sapiens 23-27 21049628-17 2010 CONCLUSION: The serum concentrations of TNF-alpha, IL-6, D-Di and PLC level were significantly increased in peroperative period, These results seem to indicate that the Tong Mai Decoctions & Lornoxicam may play an important role in inhibiting the release of TNF-alpha, IL-6, D-Di and PLC into the blood stream and decreasing the incunabula complication at early traumatic stage. Adenosine Monophosphate 190-193 interleukin 6 Homo sapiens 273-277 20526368-15 2010 Induction of IL-6 in human bladder smooth muscle cells by fatty acids may represent a pathogenetic factor underlying the higher frequency and persistence of urinary tract infections in patients with metabolic diseases. Fatty Acids 58-69 interleukin 6 Homo sapiens 13-17 20184875-4 2010 Anti-IL-6 receptor antibody significantly (but only partially) suppressed T cell activation (as indicated by [3H]-thymidine uptake and CD25 expression) and IL-2 production in both systems, and increased the frequency of regulatory T cells among spleen cells. Tritium 110-112 interleukin 6 Homo sapiens 5-9 20188080-11 2010 It was also observed that polyphenolic acetates inhibit TNF-alpha mediated release of IL-6 from peripheral blood mononuclear cells. polyphenolic acetates 26-47 interleukin 6 Homo sapiens 86-90 19769459-5 2010 In contrast, NaHS elicited a biphasic effect on proinflammatory mediators and, at high concentrations, increased the synthesis of IL-1beta, IL-6, NO, PGE(2) and TNF-alpha. sodium bisulfide 13-17 interleukin 6 Homo sapiens 140-144 20235152-5 2010 Treatment of cancer cells with curcumin induced a dose- and time-dependent decrease of constitutive IL-6 expression and of constitutive and IL-6-induced STAT-3 phosphorylation, which is associated with decreased cell viability and increased cleavage of caspase-3. Curcumin 31-39 interleukin 6 Homo sapiens 100-104 20235152-5 2010 Treatment of cancer cells with curcumin induced a dose- and time-dependent decrease of constitutive IL-6 expression and of constitutive and IL-6-induced STAT-3 phosphorylation, which is associated with decreased cell viability and increased cleavage of caspase-3. Curcumin 31-39 interleukin 6 Homo sapiens 140-144 20081092-6 2010 Lower iron was significantly correlated with higher IL-6 and CRP. Iron 6-10 interleukin 6 Homo sapiens 52-56 20360246-7 2010 In proliferating cells, channel activity was coupled negatively to interleukin-6 secretion via a calcium-dependent mechanism. Calcium 97-104 interleukin 6 Homo sapiens 67-80 20081092-7 2010 Adjusting for confounders, IL-6 and CRP remained significantly associated with serum iron, with no evidence that such a relationship was accounted for by variability in urinary hepcidin. Iron 85-89 interleukin 6 Homo sapiens 27-31 20225236-5 2010 We found that IL-6 is a powerful stimulator for MMP-1 expression and high glucose further augmented IL-6-stimulated MMP-1 expression. Glucose 74-81 interleukin 6 Homo sapiens 100-104 20463301-8 2010 In addition, WECG attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187-stimulated gene expression and secretion of proinflammatory cytokines such as tumor necrosis factor-alpha and interleukin-6 in human mast cells. Tetradecanoylphorbol Acetate 33-64 interleukin 6 Homo sapiens 204-217 20463301-8 2010 In addition, WECG attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187-stimulated gene expression and secretion of proinflammatory cytokines such as tumor necrosis factor-alpha and interleukin-6 in human mast cells. Calcium 69-76 interleukin 6 Homo sapiens 204-217 20346081-9 2010 Dexamethasone, at 50 microg/ml, decreased the viability of HRECs stimulated by IL-1alpha, IL-1beta, IL-6 and VEGF without hyalocytes but could not decrease the viability of HRECs cocultured. Dexamethasone 0-13 interleukin 6 Homo sapiens 100-104 20132164-10 2010 Heparin was able to reverse aPL-dependent inhibition of trophoblast IL-6 secretion and migration. Heparin 0-7 interleukin 6 Homo sapiens 68-72 19929981-3 2010 In the present study, we examined the effects of COS on interleukin-6 (IL-6) production in human umbilical vein endothelial cells (HUVECs) induced by lipopolysaccharide (LPS). carbonyl sulfide 49-52 interleukin 6 Homo sapiens 56-69 19929981-4 2010 Induction of HUVECs with LPS (100 ng/ml) increased the mRNA expression and protein secretion of IL-6 (versus the vehicle-treated group, p < 0.01), which were significantly reverted by the pre-treatment with COS (50-200 microg/ml) for 24 hr before LPS exposure (versus the LPS-treated group, p < 0.05 or 0.01). carbonyl sulfide 210-213 interleukin 6 Homo sapiens 96-100 19929981-8 2010 In conclusion, our results suggest that COS inhibit LPS-induced up-regulation of IL-6 in HUVECs, and this can be regulated by at least two parallel signalling pathways: one via p38 MAPK pathway independent of NF-kappaB activation and one via ERK1/2 pathway dependent on NF-kappaB activation. carbonyl sulfide 40-43 interleukin 6 Homo sapiens 81-85 20423350-5 2010 KEY RESULTS: Pre-incubation with beta(2)-adrenoceptor agonists (salbutamol, salmeterol, formoterol) augmented the release and mRNA expression of IL-6 and IL-8 induced by IL-1beta and IL-1beta plus histamine, whereas NF-kappaB-dependent transcription was significantly repressed, and AP-1-dependent transcription was unaffected. Histamine 197-206 interleukin 6 Homo sapiens 145-149 20423350-8 2010 Addition of dexamethasone with salmeterol repressed IL-6 and IL-8 release to levels that were similar to the repression achieved in the absence of salmeterol. Dexamethasone 12-25 interleukin 6 Homo sapiens 52-56 20189706-7 2010 While TNFalpha (-308) and IL-10 (-1082) genotypes did not influence clinical/laboratory parameters in PCOS, IL-6 (-174) CC or pooled CG+CC genotypes have lower glucose, insulin, HOMA, cholesterol, triglyceride, and LDL-C, and higher GIR and HDL-C values than GG genotypes. Glucose 160-167 interleukin 6 Homo sapiens 108-112 20375905-1 2010 OBJECTIVE: We hypothesized a possible mechanism for atherosclerosis in which interleukin-6 (IL-6) might affect the endothelial nitric oxide synthase (eNOS)-caveolin-1 interaction and result in decreased nitric oxide bioavailability in the setting of low-grade inflammation. Nitric Oxide 127-139 interleukin 6 Homo sapiens 77-90 20236803-3 2010 Moreover, extracellular ATP stimulates the expression and release of IL-6 and modulates the production several chemokines by keratinocytes. Adenosine Triphosphate 24-27 interleukin 6 Homo sapiens 69-73 20236803-8 2010 RESULTS: The statistical analysis of the microarray data revealed that, besides IL-6, the expression of several novel genes such as IL-20, CXCL1-3, and ATF3 was significantly augmented in ATP-stimulated keratinocytes. Adenosine Triphosphate 188-191 interleukin 6 Homo sapiens 80-84 20236803-11 2010 Since both IL-6 and IL-20 that can stimulate STAT3 were produced by the ATP-stimulated keratinocytes, we examined their phosphorylation of STAT3. Adenosine Triphosphate 72-75 interleukin 6 Homo sapiens 11-15 20236803-12 2010 The study demonstrated biphasic activation of STAT3 after ATP stimulation, which was composed of a first peak at 1-2 h and a second peak at 12-24 h. The latter peak was significantly suppressed by anti-IL-6 antibody. Adenosine Triphosphate 58-61 interleukin 6 Homo sapiens 202-206 20375905-1 2010 OBJECTIVE: We hypothesized a possible mechanism for atherosclerosis in which interleukin-6 (IL-6) might affect the endothelial nitric oxide synthase (eNOS)-caveolin-1 interaction and result in decreased nitric oxide bioavailability in the setting of low-grade inflammation. Nitric Oxide 127-139 interleukin 6 Homo sapiens 92-96 20375905-4 2010 In addition, IL-6 inhibited bradykinin-stimulated Akt phosphorylation at Ser473 and Thr 308 without affecting the Akt protein expression. Threonine 84-87 interleukin 6 Homo sapiens 13-17 20375905-7 2010 IL-6 treatment was found to stabilize caveolin-1 protein and its half-life was estimated to prolong from 7.5 h to longer than 12 h. Furthermore, treatment with PD98059 and short interference RNA of extracellular signal-regulated kinase gene reversed the effects of IL-6 on eNOS and caveolin-1. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 160-167 interleukin 6 Homo sapiens 0-4 20375905-7 2010 IL-6 treatment was found to stabilize caveolin-1 protein and its half-life was estimated to prolong from 7.5 h to longer than 12 h. Furthermore, treatment with PD98059 and short interference RNA of extracellular signal-regulated kinase gene reversed the effects of IL-6 on eNOS and caveolin-1. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 160-167 interleukin 6 Homo sapiens 265-269 20375905-8 2010 CONCLUSION: In addition to decreasing Akt phosphorylation, the results of this study demonstrate, for the first time, the molecular mechanism underlying the effect of IL-6 to decrease the nitric oxide bioavailability by increasing the half-life and, therefore, the protein levels of caveolin-1. Nitric Oxide 188-200 interleukin 6 Homo sapiens 167-171 20190028-11 2010 CONCLUSION: Short-term oral NAC treatment resulted in reduction of circulating IL-6, suggesting that such treatment could be a useful strategy in blunting the inflammatory response in PD patients. Acetylcysteine 28-31 interleukin 6 Homo sapiens 79-83 20187772-9 2010 Muscle mRNA expression for IL-8 (6.4-fold), MCP-1 (4.7-fold), and IL-6 (7.3-fold) increased substantially after carbohydrate ingestion. Carbohydrates 112-124 interleukin 6 Homo sapiens 66-70 20164300-5 2010 Our results showed that butrin, isobutrin, and butein significantly reduced the phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced inflammatory gene expression and production of TNF-alpha, IL-6, and IL-8 in HMC-1 cells by inhibiting the activation of NF-kappaB. Tetradecanoylphorbol Acetate 80-111 interleukin 6 Homo sapiens 207-211 20164300-5 2010 Our results showed that butrin, isobutrin, and butein significantly reduced the phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced inflammatory gene expression and production of TNF-alpha, IL-6, and IL-8 in HMC-1 cells by inhibiting the activation of NF-kappaB. Calcium 116-123 interleukin 6 Homo sapiens 207-211 20171655-7 2010 Urinary interleukin (IL)-6 levels were significantly higher in the study group (496.7 +/- 310.9 vs 115.0 +/- 65.9 ng/g urinary creatinine; P < .01), as were PI values (1.85 +/- 0.70 vs 1.44 +/- 0.53; P < .05). Creatinine 127-137 interleukin 6 Homo sapiens 8-26 20084405-6 2010 To avoid dilution effects and to the standardize samples, urinary levels of IL-6 and IL-8 were expressed as the ratio of cytokine to urinary creatinine (pg/mg). Creatinine 141-151 interleukin 6 Homo sapiens 76-80 20084405-8 2010 In patients with VUR, there was a significant but rather weak correlation between IL-6/creatinine concentrations and there flux grade (p<0.05, R=0.305). Creatinine 87-97 interleukin 6 Homo sapiens 82-86 20164300-0 2010 Butrin, isobutrin, and butein from medicinal plant Butea monosperma selectively inhibit nuclear factor-kappaB in activated human mast cells: suppression of tumor necrosis factor-alpha, interleukin (IL)-6, and IL-8. isobutrin 8-17 interleukin 6 Homo sapiens 185-203 20164300-5 2010 Our results showed that butrin, isobutrin, and butein significantly reduced the phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced inflammatory gene expression and production of TNF-alpha, IL-6, and IL-8 in HMC-1 cells by inhibiting the activation of NF-kappaB. isobutrin 32-41 interleukin 6 Homo sapiens 207-211 20338767-3 2010 In this study, we synthesized and examined a series of 5-carbon linker-containing mono-carbonyl analogues of curcumin with potent inhibitory activities against TNF-alpha and IL-6 release in LPS-stimulated RAW 264.7 macrophages. Carbon 57-63 interleukin 6 Homo sapiens 174-178 19823118-7 2010 Pretreatment with PD98059, an inhibitor of ERK, decreased LTA-enhanced NFkappaB activation and TNF-alpha and IL-6 mRNA syntheses. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 18-25 interleukin 6 Homo sapiens 109-113 19823118-8 2010 Cotreatment with ketamine and PD98059 synergistically suppressed the LTA-induced translocation and transactivation of NFkappaB and biosyntheses of TNF-alpha and IL-6 mRNA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 30-37 interleukin 6 Homo sapiens 161-165 20192182-0 2010 Ultrasensitive electrochemical immunosensor for oral cancer biomarker IL-6 using carbon nanotube forest electrodes and multilabel amplification. Carbon 81-87 interleukin 6 Homo sapiens 70-74 20192182-5 2010 Secondary antibodies (Ab(2)) attached to carboxylated multiwall carbon nanotubes with 106 HRP labels per 100 nm gave the highest sensitivity of 19.3 nA mL (pg IL-6)(-1) cm(-2) and the best detection limit (DL) of 0.5 pg mL(-1) (25 fM) for IL-6 in 10 microL of calf serum. Carbon 64-70 interleukin 6 Homo sapiens 159-163 20192182-5 2010 Secondary antibodies (Ab(2)) attached to carboxylated multiwall carbon nanotubes with 106 HRP labels per 100 nm gave the highest sensitivity of 19.3 nA mL (pg IL-6)(-1) cm(-2) and the best detection limit (DL) of 0.5 pg mL(-1) (25 fM) for IL-6 in 10 microL of calf serum. Carbon 64-70 interleukin 6 Homo sapiens 239-243 20207143-0 2010 Synthesis and biological evaluation of nitrogen-containing benzophenone analogues as TNF-alpha and IL-6 inhibitors with antioxidant activity. Nitrogen 39-47 interleukin 6 Homo sapiens 99-103 20207143-1 2010 A series of nitrogen-containing benzophenone analogues were synthesized by Mannich reaction and evaluated for the inhibition of pro-inflammatory cytokines, TNF-alpha and IL-6. Nitrogen 12-20 interleukin 6 Homo sapiens 170-174 19930761-9 2010 However, systemic inflammation (CRP and IL-6) was correlated with the faecal concentrations of phenolics and lactic acid (P < 0.05 and 0.05, and P < 0.01 and 0.05, respectively). Lactic Acid 109-120 interleukin 6 Homo sapiens 40-44 20110572-4 2010 METHODS AND RESULTS: THP-1 monocytes exposed to 100 micromol/L SFA in vitro for 16 hours followed by 1 ng/mL lipopolysaccharide demonstrated enhanced IL-6 and IL-8 mRNA and protein expression (approximately 3-fold higher than the sum of individual responses to SFA and lipopolysaccharide). Fatty Acids 63-66 interleukin 6 Homo sapiens 150-154 20338767-3 2010 In this study, we synthesized and examined a series of 5-carbon linker-containing mono-carbonyl analogues of curcumin with potent inhibitory activities against TNF-alpha and IL-6 release in LPS-stimulated RAW 264.7 macrophages. Curcumin 109-117 interleukin 6 Homo sapiens 174-178 20136701-7 2010 In addition, melatonin significantly reduced the activation of GSK-3beta, the phosphorylation of tau protein, the glial activation and the Abeta-induced increase of TNF-alpha and IL-6 levels. Melatonin 13-22 interleukin 6 Homo sapiens 179-183 20074254-3 2010 The aims of this study was to examined the effects of CRP on expressions of interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1), and the possible mechanisms of atorvastatin on CRP-induced IL-6 and MCP-1 production in cultured human pulmonary artery smooth muscle cells (PASMCs). Atorvastatin 176-188 interleukin 6 Homo sapiens 204-208 20074254-10 2010 Preincubation with 0.1-10 micromol/L of atorvastatin significantly decreased the secretions of IL-6 and MCP-1 induced by CRP. Atorvastatin 40-52 interleukin 6 Homo sapiens 95-99 20074254-11 2010 Moreover, 10 micromol/L of atorvastatin completely abrogated CRP-induced increase in IL-6 and MCP-1 by attenuating the activation of NF-kappaB. Atorvastatin 27-39 interleukin 6 Homo sapiens 85-89 20233902-4 2010 Growth-suppressive concentrations of SFN (20 and 40 micromol/L) decreased constitutive (DU145 cells) and IL-6-induced (DU145 and LNCaP cells) phosphorylation of STAT3 (Tyr(705)) as well as its upstream regulator Janus-activated kinase 2 (Tyr(1007/1008)). Tyrosine 168-171 interleukin 6 Homo sapiens 105-109 20233902-4 2010 Growth-suppressive concentrations of SFN (20 and 40 micromol/L) decreased constitutive (DU145 cells) and IL-6-induced (DU145 and LNCaP cells) phosphorylation of STAT3 (Tyr(705)) as well as its upstream regulator Janus-activated kinase 2 (Tyr(1007/1008)). Tyrosine 238-241 interleukin 6 Homo sapiens 105-109 20443703-5 2010 However, the Fc-mutated version T3q(Ala/Ala) displayed a much weaker FcgammaR binding capacity than the unmutated chimeric molecule T3q, as well as a reduced ability to induce T-cell proliferation, proinflammatory cytokine release (TNFalpha and IL-6), and early activation surface marker expression (CD25 and CD69). Alanine 36-39 interleukin 6 Homo sapiens 245-249 20443703-5 2010 However, the Fc-mutated version T3q(Ala/Ala) displayed a much weaker FcgammaR binding capacity than the unmutated chimeric molecule T3q, as well as a reduced ability to induce T-cell proliferation, proinflammatory cytokine release (TNFalpha and IL-6), and early activation surface marker expression (CD25 and CD69). Alanine 40-43 interleukin 6 Homo sapiens 245-249 20168253-12 2010 No relationship was observed between PO IL-6 and IGR, but PR IL-6 was negatively related to both PR (r = -0.043, p < 0.05) and 60 minutes (r = -0.59, p < 0.01) glucose (n = 14). Glucose 166-173 interleukin 6 Homo sapiens 61-65 20067446-9 2010 Data provided prove that, in FLSs, constitutive as well as IL-1beta-induced expression of IL-6 is transiently and partially down-regulated by the short treatment of cells with low concentrations of NaHS. sodium bisulfide 198-202 interleukin 6 Homo sapiens 90-94 20371718-5 2010 Perifosine inhibited rapamycin-induced phosphorylated Akt, resulting in enhanced cytotoxicity in MM.1S cells even in the presence of interleukin-6, insulin-like growth factor-I, or bone marrow stromal cells. Sirolimus 21-30 interleukin 6 Homo sapiens 133-146 19921094-0 2010 Cyclic AMP response element-binding protein is implicated in IL-6 production from arthritic synovial cells. Cyclic AMP 0-10 interleukin 6 Homo sapiens 61-65 20105457-4 2010 The chemokines CXCL2, CXCL3, IL-8/CXCL8 and CCL26, the pro-inflammatory cytokine IL-6 and the receptor IL-1RL1 were expressed at high levels after exposure to 7 microM Cd(2+) for 7h. Cadmium 168-170 interleukin 6 Homo sapiens 81-85 20105457-8 2010 Cd(2+) induced an increased release of IL-6 and MIP-2/CXCL2 from the epithelial cells and MIP-2, IL-1beta and TNF-alpha from alveolar macrophages. Cadmium ion 0-6 interleukin 6 Homo sapiens 39-43 20136831-12 2010 CONCLUSIONS AND IMPLICATIONS: Statins suppressed IL-6/sIL-6R-induced monocyte chemotaxis and MCP-1 expression in HAECs by inhibiting JAK/STAT signalling cascades, explaining why statins have anti-inflammatory properties beyond cholesterol reduction. Cholesterol 227-238 interleukin 6 Homo sapiens 49-53 20118277-6 2010 Elevated levels of intracellular reactive oxygen species triggered the production of IL-8 as well as proinflammatory cytokines, such as TNF-alpha and IL-6. Reactive Oxygen Species 33-56 interleukin 6 Homo sapiens 150-154 20016056-7 2010 Mice with very high plasma levels of aAb-IL6 developed elevated fasting plasma glucose (mM, 4.8+/-0.4 vs 3.3+/-0.1, P<0.001) and impaired glucose tolerance (AUC glucose, 1340+/-38 vs 916+/-25, P<0.001) as compared with sham-control mice on normal chow. Glucose 79-86 interleukin 6 Homo sapiens 41-44 20016056-7 2010 Mice with very high plasma levels of aAb-IL6 developed elevated fasting plasma glucose (mM, 4.8+/-0.4 vs 3.3+/-0.1, P<0.001) and impaired glucose tolerance (AUC glucose, 1340+/-38 vs 916+/-25, P<0.001) as compared with sham-control mice on normal chow. Glucose 141-148 interleukin 6 Homo sapiens 41-44 19923143-2 2010 METHODS AND RESULTS: High-glucose (HG) super-induced interleukin (IL)-6, CCL-2, transforming growth factor (TGF)-beta, vascular endothelial growth factor (VEGF) and B(2)K receptor (B(2)KR) mRNA in cultured proximal tubular epithelial cells (PTEC), whereas bradykinin (BK) upregulated IL-6, CCL-2 and TGF-beta mRNA. Glucose 26-33 interleukin 6 Homo sapiens 284-288 19923143-5 2010 Inhibition of MAPK p42/p44 by PD98059 partially reduced HG and BK induction of IL-6, CCL-2 and TGF-beta, whereas inhibition of PKC by staurosporine partially reduced HG- but not BK-induced overexpression of these cytokines and that of VEGF. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 30-37 interleukin 6 Homo sapiens 79-83 19923143-6 2010 Staurosporine and PD98059 synergistically reduced the effect of HG on IL-6, CCL-2 and TGF-beta expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 18-25 interleukin 6 Homo sapiens 70-74 19923143-9 2010 The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist, rosiglitazone, attenuated HG-induced PKC but not HG- or BK- induced MAPK p42/44 activation and reduced HG-stimulated VEGF, along with IL-6, CCL-2 and TGF-beta secretion. Rosiglitazone 75-88 interleukin 6 Homo sapiens 209-213 19879324-7 2010 Rapamycin enhanced the IL-6 synthesis and the phosphorylation of Akt induced by TNF-alpha also in human osteoblasts. Sirolimus 0-9 interleukin 6 Homo sapiens 23-27 20184737-6 2010 RESULTS: A positive correlation was found between IL-6 serum levels and severity of mucositis and dysphagia; specifically, high IL-6 levels at week 2 were correlated with a need for PEG tube installation. Polyethylene Glycols 182-185 interleukin 6 Homo sapiens 128-132 22966296-8 2010 On the other hand, curcumin attenuated the expression of IL-6 and IL-8 in the TNF-alpha-treated HaCaT cells. Curcumin 19-27 interleukin 6 Homo sapiens 57-61 19859827-1 2010 Adenosine stimulates the release of interleukin 6 (IL-6) and vascular endothelial growth factor from folliculostellate cells of the anterior pituitary gland indicating that such cells are also involved in the communication between the immune and endocrine systems during stress and inflammation. Adenosine 0-9 interleukin 6 Homo sapiens 36-49 19859827-1 2010 Adenosine stimulates the release of interleukin 6 (IL-6) and vascular endothelial growth factor from folliculostellate cells of the anterior pituitary gland indicating that such cells are also involved in the communication between the immune and endocrine systems during stress and inflammation. Adenosine 0-9 interleukin 6 Homo sapiens 51-55 19815061-7 2010 ROS also triggered pro-inflammatory responses in cultured T98G cells, which were demonstrated by the increased gene expression and protein levels of IL-6 and IL-8. ros 0-3 interleukin 6 Homo sapiens 149-153 20178563-8 2010 CONCLUSION: In patients with DCM and co-existing AF, a weaker effect of atorvastatin concerning the reduction of IL-6 and NT-proBNP concentration was observed than in patients without atrial fibrillation. Atorvastatin 72-84 interleukin 6 Homo sapiens 113-117 20007708-0 2010 Adipocyte-mononuclear cell interaction, Toll-like receptor 4 activation, and high glucose synergistically up-regulate osteopontin expression via an interleukin 6-mediated mechanism. Glucose 82-89 interleukin 6 Homo sapiens 148-161 19647363-7 2010 Treatment of the cells with curcumin inhibited LPA-induced IL-6 and IL-8 secretion and STAT3 phosphorylation, leading to blocked ovarian cancer cell motility. Curcumin 28-36 interleukin 6 Homo sapiens 59-63 19939912-8 2010 Selective GR stimulation of white adipocytes with dexamethasone inhibited the expression of interleukin 6 (IL6), monocyte chemoattractant protein-1 (MCP1 or CCL2 as listed in the MGI Database), tumour necrosis factor-alpha, chemerin and leptin. Dexamethasone 50-63 interleukin 6 Homo sapiens 92-105 19645854-1 2010 Arachidonic acid (AA) activates the 5-lipoxygenase, induces leukotriene-B(4) (LTB(4)) synthesis, enhances interleukin-6 (IL-6) release and increases intracellular neutral lipids in human sebocytes. Arachidonic Acid 0-16 interleukin 6 Homo sapiens 106-119 19645854-1 2010 Arachidonic acid (AA) activates the 5-lipoxygenase, induces leukotriene-B(4) (LTB(4)) synthesis, enhances interleukin-6 (IL-6) release and increases intracellular neutral lipids in human sebocytes. Arachidonic Acid 0-16 interleukin 6 Homo sapiens 121-125 19939912-8 2010 Selective GR stimulation of white adipocytes with dexamethasone inhibited the expression of interleukin 6 (IL6), monocyte chemoattractant protein-1 (MCP1 or CCL2 as listed in the MGI Database), tumour necrosis factor-alpha, chemerin and leptin. Dexamethasone 50-63 interleukin 6 Homo sapiens 107-110 20439185-0 2010 Vitamin D derivatives: calcitriol and tacalcitol inhibits interleukin-6 and interleukin-8 expression in human nasal polyp fibroblast cultures. Vitamin D 0-9 interleukin 6 Homo sapiens 58-71 19892012-9 2010 We found that PGE(2) enhanced IL-6 production in HTSMCs and leukocyte count in BAL fluid. Dinoprostone 14-20 interleukin 6 Homo sapiens 30-34 19892012-10 2010 In addition, treatment with nicotine could induce COX-2, PGE(2), and IL-6 generation in in vivo and in vitro studies. Nicotine 28-36 interleukin 6 Homo sapiens 69-73 19892012-11 2010 These results demonstrate that CSE-induced ROS generation was mediated through the TLR4/MyD88/TRAF6/c-Src/NADPH oxidase pathway, in turn initiated the activation of MAPKs and NF-kappaB, and ultimately induced COX-2/PGE(2)/IL-6-dependent airway inflammation. ros 43-46 interleukin 6 Homo sapiens 222-226 19923180-8 2010 The peak of IL-6 production in infected animals paralleled the ability of animals infected with NS4B.VGIv to resist challenge with virulent BICv. bicv 140-144 interleukin 6 Homo sapiens 12-16 19923180-9 2010 Interestingly, treatment of peripheral blood mononuclear cell cultures with recombinant porcine IL-6 results in a significant decrease in BICv replication. bicv 138-142 interleukin 6 Homo sapiens 96-100 19942655-5 2010 The addition of acetylsalicylic acid had significantly suppressive effect on the IL-6 production by lipopolysaccharide-stimulated patients" peripheral blood mononuclear cells. Aspirin 16-36 interleukin 6 Homo sapiens 81-85 20026056-3 2010 We here showed that synthetic dsRNA, polyI:C, caused peripheral expansion of functional Treg in a TICAM-1- and IL-6-dependent manner in vivo. Poly I 37-42 interleukin 6 Homo sapiens 111-115 20942931-11 2010 Urine IL-6 did not significantly increase in pre-renal azotemia but did increase in ischemic and cisplatin AKI. Cisplatin 97-106 interleukin 6 Homo sapiens 6-10 21067533-2 2010 In the previous issue of Arthritis Research & Therapy, Boettger and colleagues examine the role of IL-6 in antigen-induced arthritis using the IL-6 neutralizing soluble glycoprotein 130 and link IL-6 to a pathophysiological role in the generation of pain, independent of the proinflammatory properties of IL-6. Adenosine Monophosphate 45-48 interleukin 6 Homo sapiens 103-107 20851386-6 2010 Western blot analysis of STAT3 phosphorylation showed that this augmented response in HT-29 cells following IL-10 neutralization is probably mediated through enhanced IL-6-induced phosphorylation (Tyr(705)) of STAT3 proteins. Tyrosine 197-200 interleukin 6 Homo sapiens 167-171 19360465-3 2010 Of the analyzed genes, ERCC2, XRCC1, XRCC2, XRCC3 and Lig4 participate in DNA repair, TP53 in cell cycle check point control, AIB1, AR, COMT, CYP11A1, CYP17A1, CYP19A1, HSD17 and PGR in steroid hormone biosynthesis/metabolism/signaling, TYMS in folate metabolism and HER2, IL6, LRP1, TGFB and TGFBR1 affect cell growth. Steroids 186-201 interleukin 6 Homo sapiens 273-276 19360465-3 2010 Of the analyzed genes, ERCC2, XRCC1, XRCC2, XRCC3 and Lig4 participate in DNA repair, TP53 in cell cycle check point control, AIB1, AR, COMT, CYP11A1, CYP17A1, CYP19A1, HSD17 and PGR in steroid hormone biosynthesis/metabolism/signaling, TYMS in folate metabolism and HER2, IL6, LRP1, TGFB and TGFBR1 affect cell growth. Folic Acid 245-251 interleukin 6 Homo sapiens 273-276 20036937-6 2010 Administration of resveratrol can inhibit NF-kappaB activity as well as reduce the concentrations of TNF-alpha, IL-6 and IL-1. Resveratrol 18-29 interleukin 6 Homo sapiens 112-116 20164544-2 2010 Interleukin-6 (IL-6) is a cytokine involved in inflammatory process, as well as in glucose and lipid metabolism. Glucose 83-90 interleukin 6 Homo sapiens 0-13 20164544-2 2010 Interleukin-6 (IL-6) is a cytokine involved in inflammatory process, as well as in glucose and lipid metabolism. Glucose 83-90 interleukin 6 Homo sapiens 15-19 19907186-0 2010 Histamine stimulates interleukin-6 production through histamine H1 receptors in human amnion cells. Histamine 0-9 interleukin 6 Homo sapiens 21-34 19907186-7 2010 CONCLUSION: Histamine appears to induce IL-6 production through H1R in human amnion cells. Histamine 12-21 interleukin 6 Homo sapiens 40-44 19907186-5 2010 Histamine stimulation significantly increased concentrations of IL-6 in conditioned medium, as did tumor necrosis factor-alpha and IL-1beta in positive controls. Histamine 0-9 interleukin 6 Homo sapiens 64-68 19907186-6 2010 In addition, the H1R antagonist olopatadine significantly blocked histamine-induced production of IL-6, whereas the H2R antagonist ranitidine did not. Histamine 66-75 interleukin 6 Homo sapiens 98-102 20209309-4 2010 In addition, serum IL-6 concentrations presented a significant positive correlation with the duration of oxygen therapy and with the length of hospital stay. Oxygen 105-111 interleukin 6 Homo sapiens 19-23 19818417-8 2010 Both treatments combined caused the greatest suppression of gene expression; -4.47. qPCR also showed that IL-1beta, GM-CSF and IL-6 mRNA levels were significantly reduced by CSE and further suppressed by dexamethasone. Dexamethasone 204-217 interleukin 6 Homo sapiens 127-131 22084588-8 2010 KYN/TRP correlated with neopterin (p < 0.001) and also with TNF-alpha (p < 0.01) and IL-6 concentrations (p < 0.05) and inversely with the in vitro response of stimulated monocytes. Tryptophan 4-7 interleukin 6 Homo sapiens 91-95 19789931-7 2010 Moreover, AAS significantly inhibited production of inflammatory cytokines, tumor necrosis factor (TNF), interleukin (IL)-6, and IL-8 on the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated human mast cell line, HMC-1 cells. Tetradecanoylphorbol Acetate 141-172 interleukin 6 Homo sapiens 105-123 19789931-7 2010 Moreover, AAS significantly inhibited production of inflammatory cytokines, tumor necrosis factor (TNF), interleukin (IL)-6, and IL-8 on the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated human mast cell line, HMC-1 cells. Calcium 177-184 interleukin 6 Homo sapiens 105-123 20110595-5 2010 Basal and PMA-stimulated levels of IFN-gamma, TNF-alpha, and IL-6 were measured by ELISPOT (PBMC culture supernatant). Tetradecanoylphorbol Acetate 10-13 interleukin 6 Homo sapiens 61-65 20209309-6 2010 The serum levels of IL-6 determined at admission could also be used to predict prolonged oxygen supplementation and hospital stay. Oxygen 89-95 interleukin 6 Homo sapiens 20-24 20615159-9 2010 IL-6, TNF, and IL-8 were higher in patients vs. controls before treatment (p < 0.05&#x2013;0.001), and decreased after treatment in patients (p < 0.001) but did not change in controls. Adenosine Monophosphate 87-90 interleukin 6 Homo sapiens 0-4 20533854-8 2010 H2O2) and NO directly correlated with IL-6, IL-10, IL-1beta, TNFalpha and glutathione. Hydrogen Peroxide 0-4 interleukin 6 Homo sapiens 38-42 21173747-2 2010 DESIGN: The aim of our study was to determine if there is a difference between metal influenced IL-1beta, IL-4, IL-6, TNF-alpha and IFN-gamma cytokines production in patients with successfully healed implants compared to those, whose implant therapy was unsuccessful. Metals 79-84 interleukin 6 Homo sapiens 112-116 21173747-6 2010 Titanium caused significantly increased IL-6 production in all patients. Titanium 0-8 interleukin 6 Homo sapiens 40-44 21173747-9 2010 CONCLUSIONS: Increased production of IL-1beta a IL-6 cytokines in reaction to titanium and increased production of TNF-alpha and IFN-gamma cytokines in reaction to mercury, which is very often present in the form of amalgam in the oral cavity of persons in need of implant therapy, can play an important role in immune reactions during implant healing process. Titanium 78-86 interleukin 6 Homo sapiens 48-52 22966259-12 2010 The change in serum interleukin-6 levels was significantly associated with a response to DXM (P=0.0065). Dexamethasone 89-92 interleukin 6 Homo sapiens 20-33 20731121-0 2010 [Influence of polyoxidonium on IL-1 beta, TNF-alpha and IL-6 production by mononuclears and monocytes under the dexamethasone effect]. Dexamethasone 112-125 interleukin 6 Homo sapiens 56-60 19537921-7 2010 The level of interleukin-6 (IL-6) was increased and positively correlated with thiol redox (r=0.423) in the preparatory period, whereas tumor necrosis factor alpha (TNFalpha) was increased and inversely correlated with thiol redox (r= 0.509) in the play-off round. Sulfhydryl Compounds 79-84 interleukin 6 Homo sapiens 13-26 19537921-7 2010 The level of interleukin-6 (IL-6) was increased and positively correlated with thiol redox (r=0.423) in the preparatory period, whereas tumor necrosis factor alpha (TNFalpha) was increased and inversely correlated with thiol redox (r= 0.509) in the play-off round. Sulfhydryl Compounds 79-84 interleukin 6 Homo sapiens 28-32 21103619-7 2010 RESULTS: The IL-2 production of T-lymphocytes was a deficient one (low seric levels in the majority of the patients), while cytokines IL-6, IL-8 and TNF-alpha showed high seric levels. seric 171-176 interleukin 6 Homo sapiens 134-138 19826119-13 2009 Reducing the number of weekly treatments per cycle from four to three and adding prophylactic dexamethasone, which abrogated interleukin-6 release and CRS (P < or = .01), resulted in improved tolerability and treatment delivery. Dexamethasone 94-107 interleukin 6 Homo sapiens 125-138 20056081-0 2010 [Relationship of IL-6 and IL-8 secretion in epithelial ovarian cancer cell lines with their sensitivity to tamoxifen as well as MAPK, Akt and estrogen receptor phosphorylation]. Tamoxifen 107-116 interleukin 6 Homo sapiens 17-21 20056081-1 2010 AIM: To investigate the relationship of IL-6 and IL-8 secretion in four epithelial ovarian cancer cell lines (A2780, CAOV-3, SKOV-3 and ES-2) with their sensitivity to tamoxifen (TAM) as well as MAPK, Akt and estrogen receptor (ER) phosphorylation, and to explore the mechanism of endocrine therapy resistance caused by IL-6 and IL-8 in ovarian cancer cells. Tamoxifen 168-177 interleukin 6 Homo sapiens 40-44 20056081-10 2010 CONCLUSION: Autocrine production of IL-6 and IL-8 in epithelial ovarian cancer cell lines is inversely associated with cell response to TAM, and positively associated with phosphorylated MAPK, Akt and ER. Tamoxifen 136-139 interleukin 6 Homo sapiens 36-40 19826413-8 2009 In MyD88(+) SCOV3 cells, LPS or PTX binding to TLR4 induced IRAK4 activation and cJun phosphorylation, activated the NF-kappaB pathway and promoted interleukin (IL)-8, IL-6, vascular endothelial growth factor and monocyte chemotactic protein-1 production and resistance to drug-induced apoptosis. Paclitaxel 32-35 interleukin 6 Homo sapiens 168-172 19552994-14 2009 IL-6 levels at baseline correlated significantly and negatively with minimum nocturnal oxygen saturation. Oxygen 87-93 interleukin 6 Homo sapiens 0-4 20003221-14 2009 The concentration of IL-6 following rosiglitazone exposure did not significantly decrease comparing to control. Rosiglitazone 36-49 interleukin 6 Homo sapiens 21-25 19683936-14 2009 CONCLUSION: Compared with simple cold blood cardioplegia in heart valve replacement patients, ADO pretreatment as an adjunct to 1 mmol l(-1) ADO cold blood cardioplegia may reduce cTnI, IL-6 and IL-8 release, resulting in reduced myocardial injury in ultrastructure after surgery. Adenosine 94-97 interleukin 6 Homo sapiens 186-190 19592000-5 2009 RESULTS: In men, serum total cholesterol was higher in IL6 -174 GG (5.70+/-0.88mmol/L) than in the GC (5.51+/-0.98mmol/L) or CC (5.38+/-0.97mmol/L, mean+/-SD, p=0.0059) groups. Cholesterol 29-40 interleukin 6 Homo sapiens 55-58 20029520-1 2009 This aims of this study were to investigate the effects of carbohydrate availability during endurance training on the plasma interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-alpha response to a subsequent acute bout of high-intensity interval exercise. Carbohydrates 59-71 interleukin 6 Homo sapiens 125-143 19009233-6 2009 In addition, trichodimerol blocked IFN-gamma, IL-6 and IL-4 induced activation of Stat1, Stat3 and Stat6 transcription factors by inhibiting serine and tyrosine phosphorylation. Serine 141-147 interleukin 6 Homo sapiens 46-50 19009233-6 2009 In addition, trichodimerol blocked IFN-gamma, IL-6 and IL-4 induced activation of Stat1, Stat3 and Stat6 transcription factors by inhibiting serine and tyrosine phosphorylation. Tyrosine 152-160 interleukin 6 Homo sapiens 46-50 20093746-12 2009 rhTGF-beta1 and/or CPT-11 may potentate resistance to chemotherapy by increasing HSP and MRP expression but, on the other hand, they may limit tumour cell spread by decreasing the level of some soluble mediators of inflammation (IL-6 and NO). Irinotecan 19-25 interleukin 6 Homo sapiens 229-233 19897783-5 2009 In human gingival fibroblasts, cyclosporin alone did not induce evident inflammatory responses, but augmented the expression of CD54 and the production of interleukin (IL)-6 and IL-8 induced by TLR ligands, whereas phenytoin attenuated those responses. Cyclosporine 31-42 interleukin 6 Homo sapiens 155-173 19908944-4 2009 Pre-incubation of cells with the cannabinoid receptor CB2 antagonist SR 144528 (SR2), but not the CB1 antagonist Rimonabant or the TRPV1 antagonist capsazepine, partially prevented the anti-proliferative effect, the ceramide accumulation, and the IL-6-induced secretion, suggesting a CB2 receptor-dependent mechanism. SR 144528 69-78 interleukin 6 Homo sapiens 247-251 19908944-4 2009 Pre-incubation of cells with the cannabinoid receptor CB2 antagonist SR 144528 (SR2), but not the CB1 antagonist Rimonabant or the TRPV1 antagonist capsazepine, partially prevented the anti-proliferative effect, the ceramide accumulation, and the IL-6-induced secretion, suggesting a CB2 receptor-dependent mechanism. SR 144528 80-83 interleukin 6 Homo sapiens 247-251 20358354-8 2009 The association between body fat mass and plasma glucose was influenced by the -174G/C polymorphism of the IL6 gene. Glucose 49-56 interleukin 6 Homo sapiens 107-110 19929574-9 2009 Our data demonstrate that the lack of activation of signal transduction pathway observed following cholesterol depletion differently modulates the release of interleukin-6 (IL-6) or tumor necrosis factor-alpha (TNF-alpha), suggesting that Src, associated to lipid domains, may represent an important pathway in Gram-negative-induced cellular signal. Cholesterol 99-110 interleukin 6 Homo sapiens 158-171 19929574-9 2009 Our data demonstrate that the lack of activation of signal transduction pathway observed following cholesterol depletion differently modulates the release of interleukin-6 (IL-6) or tumor necrosis factor-alpha (TNF-alpha), suggesting that Src, associated to lipid domains, may represent an important pathway in Gram-negative-induced cellular signal. Cholesterol 99-110 interleukin 6 Homo sapiens 173-177 19782427-6 2009 The importance of ERK activation in mediating the synergism of the two cytokines is further confirmed by the inhibitory effect of the anti-diabetic drug rosiglitazone and ERK blockers on IP-10, MIG and IL-6 secretion. Rosiglitazone 153-166 interleukin 6 Homo sapiens 202-206 19670249-9 2009 Transcription up-regulation of IL-6 and IL-8 was associated with re-expression of the serine active-site mutant prostasin in the PC-3 cells. Serine 86-92 interleukin 6 Homo sapiens 31-35 19946241-4 2009 RESULTS: In group A (vs group B), IL-6 was significantly lower (p<0.0001) after 2 months of treatment with atorvastatin. Atorvastatin 110-122 interleukin 6 Homo sapiens 34-38 19946241-9 2009 CONCLUSIONS: Atorvastatin treatment significantly decreases the concentration of IL-6, and NT-proBNP in patients with DCM after 2 months of therapy. Atorvastatin 13-25 interleukin 6 Homo sapiens 81-85 19850345-4 2009 Furthermore, Zn(2+), an anti-inflammatory antioxidant, which is required for the biological activity of thymulin, independently reduced the secretion of IL-1beta, TNF-alpha and, to a lesser extent, at a supraphysiologic dose (1 mM), IL-6. Zinc 13-18 interleukin 6 Homo sapiens 233-237 20214329-7 2009 CONCLUSION: Injecting puerarin before CPB could effectively suppress the pro-inflammatory cytokines like TNF-alpha, IL-6 and IL-8; and enhance the expression of anti-inflammatory cytokines like IL-10, thus to alleviate the inflammatory reaction induced by CPB. puerarin 22-30 interleukin 6 Homo sapiens 116-120 19956406-8 2009 The result of ELISA also showed the release of IL-6 and IL-8 can also be inhibited by hydrocortisone. Hydrocortisone 86-100 interleukin 6 Homo sapiens 47-51 19956602-4 2009 A strong correlation between IL-6 secretion, measured by ELISA, and resistance to doxorubicin as ionizing radiations was observed in the multiple myeloma U266 and the Burkitt"s lymphoma Daudi and Namalwa cells. Doxorubicin 82-93 interleukin 6 Homo sapiens 29-33 19956602-6 2009 This lack of effect could be related to diverse factors: 1) a higher release of the soluble form of IL-6 receptor gp80 in response to doxorubicin and irradiation from all cell lines, 2) an impaired level of the IL-6 pathway inhibitor SOCS3 in Daudi cells, and 3) an increased release of IL-10 and TNFalpha, two cytokines involved in cell radio- and chemoresistance. Doxorubicin 134-145 interleukin 6 Homo sapiens 100-104 19783654-6 2009 The interaction of apoA-I with ABCA1-expressing macrophages suppressed the ability of lysopolysaccaride to induce the inflammatory cytokines interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha, which was reversed by silencing STAT3 or ABCA1. lysopolysaccaride 86-103 interleukin 6 Homo sapiens 160-206 19956406-6 2009 RESULTS: Incubation of HCFs with hydrocortisone markedly inhibited the expression of TLR2 and TLR4 mRNAs and decreased the release of IL-6 and IL-8 in a dose-dependent manner. Hydrocortisone 33-47 interleukin 6 Homo sapiens 134-138 19585572-11 2009 Although female patients showed a weak negative correlation between serum IL-6 levels and estradiol levels, the lower risk of HCC in female patients cannot be fully explained by estrogen-mediated inhibition of IL-6 production. Estradiol 90-99 interleukin 6 Homo sapiens 74-78 19741199-9 2009 Finally, we observed that nicotine and GTS-21 treatment decreased levels of SOCS3 (suppressor of cytokine signaling; a regulator of the inflammatory activity of IL-6) in activated endothelial cells. Nicotine 26-34 interleukin 6 Homo sapiens 161-165 19907654-4 2009 We provide evidence for decreased DNA fragmentation, reduced mitochondrial membrane depolarization, impaired reactive oxygen species production, diminished cytochrome c release and increased IL-6 production compared to healthy subjects after PMA exposure. Tetradecanoylphorbol Acetate 242-245 interleukin 6 Homo sapiens 191-195 19741199-5 2009 Treatment of macrovascular human umbilical vein endothelial cells (HUVECs) and microvascular endothelial cells (MVECs) with the cholinergic agonists nicotine and GTS-21 significantly reduced IL-6-mediated monocyte chemoattractant protein-1 (MCP-1) production and ICAM-1 expression which are regulated through the JAK2/STAT3 pathway. Nicotine 149-157 interleukin 6 Homo sapiens 191-195 19741020-8 2009 High glucose (25 mM) increased TNF-alpha, IL-6, and monocyte chemoattractant protein-1 in mesangial cell conditioned medium. Glucose 5-12 interleukin 6 Homo sapiens 42-46 19741199-9 2009 Finally, we observed that nicotine and GTS-21 treatment decreased levels of SOCS3 (suppressor of cytokine signaling; a regulator of the inflammatory activity of IL-6) in activated endothelial cells. 3-(2,4-dimethoxybenzylidene)anabaseine 39-45 interleukin 6 Homo sapiens 161-165 19759193-6 2009 Caffeic acid phenethyl ester and parthenolide inhibited NF-kappaB activation, as seen by gel shift assays and immunoblotting for p65 in nuclear fractions, as well as decreased production of IL-6 and MCP-1. parthenolide 33-45 interleukin 6 Homo sapiens 190-194 19847865-8 2009 Dexamethasone was associated with significantly lower peritoneal fluid interleukin (IL) 6 and IL-13 concentrations on day 1, and these correlated with changes in the ICFS score. Dexamethasone 0-13 interleukin 6 Homo sapiens 71-89 19759193-7 2009 Supplementation of MC3T3-E1 with methylseleninic acid (MSA) (0.5 microM to 4 microM) reduced the activation of NF-kappaB leading to a decrease in IL-6, MCP-1, COX-2 and iNOS in response to MDA-MB-231 conditioned medium. methylselenic acid 33-53 interleukin 6 Homo sapiens 146-150 19759193-7 2009 Supplementation of MC3T3-E1 with methylseleninic acid (MSA) (0.5 microM to 4 microM) reduced the activation of NF-kappaB leading to a decrease in IL-6, MCP-1, COX-2 and iNOS in response to MDA-MB-231 conditioned medium. methylselenic acid 55-58 interleukin 6 Homo sapiens 146-150 19903376-6 2009 KEY FINDINGS: The blood levels of hs-CRP, TNF-alpha, IL-6 and TXB2 were significantly decreased after 2 weeks of treatment with 300 mg/day of aspirin. Aspirin 142-149 interleukin 6 Homo sapiens 53-57 19592412-1 2009 Glucose ingestion during exercise attenuates the release of the myokine interleukin-6 (IL-6) from working skeletal muscle, which results in a diminished increase in plasma IL-6. Glucose 0-7 interleukin 6 Homo sapiens 72-85 19592412-1 2009 Glucose ingestion during exercise attenuates the release of the myokine interleukin-6 (IL-6) from working skeletal muscle, which results in a diminished increase in plasma IL-6. Glucose 0-7 interleukin 6 Homo sapiens 87-91 19592412-1 2009 Glucose ingestion during exercise attenuates the release of the myokine interleukin-6 (IL-6) from working skeletal muscle, which results in a diminished increase in plasma IL-6. Glucose 0-7 interleukin 6 Homo sapiens 172-176 19592412-7 2009 The IL-6Ralpha density increased to a lesser extent in the Glc-leg, suggesting that glucose ingestion attenuates the effect of training on IL-6Ralpha by blunting the IL-6 response. Glucose 84-91 interleukin 6 Homo sapiens 4-8 19729077-6 2009 Apigenin significantly inhibited the nicotine- and LPS-induced production of NO, PGE2, IL-1beta, TNF-alpha, IL-6, and IL-12, and the upregulation of iNOS and COX-2 in hPDL cells. Nicotine 37-45 interleukin 6 Homo sapiens 108-112 19675564-2 2009 Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion. Phosphatidylserines 65-83 interleukin 6 Homo sapiens 215-218 19675564-2 2009 Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion. Phosphatidylserines 85-87 interleukin 6 Homo sapiens 215-218 19845487-12 2009 H(2)O(2) was inhibited by 72%, nitrate 96%, TNF 90%, IL1 21%, IL6 42%. Hydrogen Peroxide 0-8 interleukin 6 Homo sapiens 62-65 19732285-6 2009 Nicotine suppresses IL-1beta and IL-6 expression at least in part by inhibiting NFkappaB activation. Nicotine 0-8 interleukin 6 Homo sapiens 33-37 19641491-5 2009 Levels of CRP and IL-6 also decreased after 20 weeks of sertraline treatment, whereas they did not significantly change in the placebo group. Sertraline 56-66 interleukin 6 Homo sapiens 18-22 19543691-5 2009 Adipose tissue-derived IL-6 may have an effect on metabolism through several mechanisms, including adipose tissue-specific gene expression, triglyceride release, lipoprotein lipase downregulation, insulin sensitivity, and so on. Triglycerides 140-152 interleukin 6 Homo sapiens 23-27 19903376-8 2009 The blood level of IL-6 in the 300 mg/day aspirin group was significantly lower than that in the other two groups after 2 weeks of therapy. Aspirin 42-49 interleukin 6 Homo sapiens 19-23 19447215-8 2009 In vitro studies showed that NSAIDs augmented IL-1beta- and IL-6-induced production of MMPs from human chondrocytes, while completely inhibiting the IL-1beta- and IL-6/sIL-6R-induced production of prostaglandin E(2) (PGE(2)). Dinoprostone 197-215 interleukin 6 Homo sapiens 60-64 19604525-9 2009 We also found that postprandial plasma concentrations of IL-6 were lower in subjects with a normal glucose tolerance (n = 69) compared with individuals with an impaired glucose tolerance (n = 11). Glucose 99-106 interleukin 6 Homo sapiens 57-61 19447215-8 2009 In vitro studies showed that NSAIDs augmented IL-1beta- and IL-6-induced production of MMPs from human chondrocytes, while completely inhibiting the IL-1beta- and IL-6/sIL-6R-induced production of prostaglandin E(2) (PGE(2)). Dinoprostone 197-215 interleukin 6 Homo sapiens 163-167 19525101-7 2009 RESULTS: Dexamethasone enhanced the phagocytic capacity of A549 cells and inhibited the production of IL-6 and IL-8 from A549 cells stimulated by LPS. Dexamethasone 9-22 interleukin 6 Homo sapiens 102-106 20716919-0 2009 cAMP activates the generation of reactive oxygen species and inhibits the secretion of IL-6 in peripheral blood mononuclear cells from type 2 diabetic patients. Cyclic AMP 0-4 interleukin 6 Homo sapiens 87-91 20716919-4 2009 When cells were cultured in the presence of a cAMP-elevating agent, the level of IL-6 decreased has by 46% in the supernatant of PBMNC from DM2 patients but it remained unaltered in controls. Cyclic AMP 46-50 interleukin 6 Homo sapiens 81-85 20716919-7 2009 cAMP elevating agents have activated the production of harmful reactive oxidant down modulated IL-6 secretion by these cells from DM2 patients, suggesting an alteration in the metabolic response possibly due to hyperglicemia. Cyclic AMP 0-4 interleukin 6 Homo sapiens 95-99 19525101-9 2009 CONCLUSIONS: The present study showed that all of the investigated anti-asthmatic drugs including dexamethasone, aminophylline and terbutaline play an anti-inflammatory effect by decreasing the release of IL-6 and IL-8 induced by LPS. Dexamethasone 98-111 interleukin 6 Homo sapiens 205-209 19656660-5 2009 OBJECTIVE: We evaluated whether GS-HCl modulates expression of COX-2 and/or MMPs by IL-1beta or PMA in human skin fibroblasts (HSF) or keratinocytes (HaCaT). gs-hcl 32-38 interleukin 6 Homo sapiens 127-130 19865006-8 2009 Penetration of morphine metabolites into the central nervous system increased in proportion to the neuroinflammatory response as demonstrated by the positive correlation between cerebrospinal fluid interleukin-6 exposure and the area under the curve cerebrospinal fluid/plasma ratio for morphine-3-glucuronide (r = .49, p < .001) and morphine-6-glucuronide (r = .51, p < .001). Morphine 15-23 interleukin 6 Homo sapiens 198-211 19882048-9 2009 Thus, by increasing direct absorption of blood glucose by skeletal muscle, IL-6 can have a beneficial role in continuing the activities of diabetic patients. Glucose 47-54 interleukin 6 Homo sapiens 75-79 19737233-8 2009 Tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and growth-related oncogene (GRO)-alpha displayed the greatest sensitivity to dexamethasone in COPD patients, while IL-8, granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) were the least sensitive. Dexamethasone 133-146 interleukin 6 Homo sapiens 36-54 19636315-12 2009 BMI-SDS significantly correlated with sTfR (P=0.009), serum hepcidin (P=0.005) and the three measures of subclinical inflammation, namely CRP (P<0.001), IL-6 (P<0.001) and leptin (P<0.001). bmi-sds 0-7 interleukin 6 Homo sapiens 156-160 19656660-6 2009 METHODS: HSF or HaCaT cells were exposed to IL-1beta or PMA without or with GS-HCl. gs-hcl 76-82 interleukin 6 Homo sapiens 9-12 19656660-8 2009 MTS assay was utilized to assess the cytotoxicity of GS-HCl on HSF cells. gs-hcl 53-59 interleukin 6 Homo sapiens 63-66 19656660-11 2009 Of interest, treatment with GS-HCl (10mM) led to blockage of p38 MAPK activation, accumulation of 66kDa COX-2 protein variant (without affecting COX-2 mRNA expression), and transcriptional down-regulation of MMP-13 in the IL-1beta- or PMA-treated HSF cells. gs-hcl 28-34 interleukin 6 Homo sapiens 247-250 19706767-6 2009 Addition of DTT or glutathione prevents the JAK cross-linking and blocks the inhibitory effects of HJB on IL-6-induced STAT3 activation, suggesting that HJB may react with cystein residues of JAKs to form covalent bonds that inactivate JAKs. Glutathione 19-30 interleukin 6 Homo sapiens 106-110 19595669-0 2009 Aspirin induces apoptosis through the blockade of IL-6-STAT3 signaling pathway in human glioblastoma A172 cells. Aspirin 0-7 interleukin 6 Homo sapiens 50-54 19595669-6 2009 We also showed that the expression and secretion of interleukin-6 (IL-6), leading to STAT3 phosphorylation, was inhibited by aspirin. Aspirin 125-132 interleukin 6 Homo sapiens 52-65 19595669-6 2009 We also showed that the expression and secretion of interleukin-6 (IL-6), leading to STAT3 phosphorylation, was inhibited by aspirin. Aspirin 125-132 interleukin 6 Homo sapiens 67-71 19595669-7 2009 When administered exogenous IL-6 to aspirin-treated A172 cells, the phosphorylation of STAT3 and cellular apoptosis were restrained compared to aspirin only-treated cells. Aspirin 36-43 interleukin 6 Homo sapiens 28-32 19595669-7 2009 When administered exogenous IL-6 to aspirin-treated A172 cells, the phosphorylation of STAT3 and cellular apoptosis were restrained compared to aspirin only-treated cells. Aspirin 144-151 interleukin 6 Homo sapiens 28-32 19595669-8 2009 Taken together, our results indicate that aspirin causes apoptosis via down-regulation of IL-6-dependent STAT3 signaling, suggesting that aspirin could be therapeutically useful for a potential anti-glioblastoma therapeutic approach. Aspirin 42-49 interleukin 6 Homo sapiens 90-94 19595669-8 2009 Taken together, our results indicate that aspirin causes apoptosis via down-regulation of IL-6-dependent STAT3 signaling, suggesting that aspirin could be therapeutically useful for a potential anti-glioblastoma therapeutic approach. Aspirin 138-145 interleukin 6 Homo sapiens 90-94 19673614-10 2009 Also, the patients who received rosiglitazone had reduced inflammatory responses to infection, compared with the patients who received a placebo (ie, interleukin-6 levels at 24 h [p < .005] and at 48 h [p = .013] and monocyte chemoattractant protein-1 level at 48 h [p = .05]). Rosiglitazone 32-45 interleukin 6 Homo sapiens 150-163 20302038-6 2009 Treatment with 40 mM of EtOH also increased IL-6 release from HUVECs without enhancement mRNA expression. Ethanol 24-28 interleukin 6 Homo sapiens 44-48 20302038-7 2009 Although EtOH inhibited LPS-induced IL-6 mRNA expression, 20 mM of EtOH still had an increasing effect on the release of IL-6. Ethanol 9-13 interleukin 6 Homo sapiens 36-40 20302038-7 2009 Although EtOH inhibited LPS-induced IL-6 mRNA expression, 20 mM of EtOH still had an increasing effect on the release of IL-6. Ethanol 67-71 interleukin 6 Homo sapiens 121-125 20302038-10 2009 In conclusion, EtOH enhances procoagulant status via VWF release and IL-6 production cooperation with LPS and may contribute to soft blood clot formation in cadaveric blood. Ethanol 15-19 interleukin 6 Homo sapiens 69-73 19706767-6 2009 Addition of DTT or glutathione prevents the JAK cross-linking and blocks the inhibitory effects of HJB on IL-6-induced STAT3 activation, suggesting that HJB may react with cystein residues of JAKs to form covalent bonds that inactivate JAKs. Cysteine 172-179 interleukin 6 Homo sapiens 106-110 19616541-6 2009 Treatment with either 5-ASA or taurine chloramine (TauCl) inhibited IL-1beta-mediated NFkappaB dependent luciferase expression and IL-6 secretion. Mesalamine 22-27 interleukin 6 Homo sapiens 131-135 19839871-8 2009 The result of ELISA also showed the release of IL-6 and IL-8 can be inhibited by hydrocortisone. Hydrocortisone 81-95 interleukin 6 Homo sapiens 47-51 18926686-6 2009 Retinoic acid also repressed LPS-induced transcription of NF-kappaB target genes such as IL-6, MCP-1 and COX-2. Tretinoin 0-13 interleukin 6 Homo sapiens 89-93 19575453-0 2009 Aggravation by prostaglandin E2 of interleukin-6-dependent insulin resistance in hepatocytes. Dinoprostone 15-31 interleukin 6 Homo sapiens 35-48 18624749-5 2009 Among inflammatory mediators, interleukin (IL)-6 had a central role as predictive factor of leptin, reactive oxygen species and glutathione peroxidase. Reactive Oxygen Species 100-123 interleukin 6 Homo sapiens 30-48 19622115-0 2009 IL-6 levels in migraine patients receiving topiramate. Topiramate 43-53 interleukin 6 Homo sapiens 0-4 19592054-7 2009 Finally, L-arginine increased insulin sensitivity index (P < .05) and adiponectin (P < .01) and decreased interleukin-6 and monocyte chemoattractant protein-1 levels. Arginine 9-19 interleukin 6 Homo sapiens 112-125 19528071-5 2009 Selection of a 32-residue random library against interleukin-6 receptor generated novel peptides containing multiple disulfide bonds with a unique linkage for its function. Disulfides 117-126 interleukin 6 Homo sapiens 49-62 19523965-5 2009 Repetitive adult exposure to the NMDA-R antagonist ketamine increases the levels of the proinflammatory cytokine interleukin-6 in brain which, through activation of the superoxide-producing enzyme NADPH oxidase (Nox2), leads to the loss of the GABAergic phenotype of PV-interneurons and to decreased inhibitory activity in prefrontal cortex. Superoxides 169-179 interleukin 6 Homo sapiens 113-126 19549813-7 2009 This analysis indicated that copper modulates signal transduction pathways associated with MAPK, NF-kappaB, death receptor, IGF-I, hypoxia, IL-10, IL-2, IL-6, EGF, Toll-like receptor, protein ubiquitination, xenobiotic metabolism, leukocyte extravasation, complement and coagulation, and sonic hedgehog signaling. Copper 29-35 interleukin 6 Homo sapiens 153-157 19607861-4 2009 Pretreatment with progesterone can significantly inhibit TLR4 and TLR9-triggered IL-6 and nitric oxide (NO) production in macrophages. Progesterone 18-30 interleukin 6 Homo sapiens 81-85 19131641-8 2009 Administration of rapamycin also decreased the severity of lung injury after intratracheal LPS or PAM administration, as determined by diminished neutrophil accumulation in the lungs, reduced interstitial pulmonary edema, and diminished levels of TNF-alpha and IL-6 in bronchoalveolar lavage fluid. Sirolimus 18-27 interleukin 6 Homo sapiens 261-265 19503092-10 2009 Furthermore, Cyp depletion or treatment with CsA induced apoptosis in IL-6-dependent multiple myeloma cells, whereas an IL-6-independent line was not affected. Cyclosporine 45-48 interleukin 6 Homo sapiens 70-74 19268915-12 2009 CONCLUSIONS: We propose a role for CSF IL-6 in the symptomatology of suicidal behavior, possibly through mechanisms involving alterations of dopamine and serotonin metabolism. Dopamine 141-149 interleukin 6 Homo sapiens 39-43 19465513-7 2009 TNFalpha-induced eotaxin, RANTES, and IL-6 as well as PDGF-BB-induced IL-6 expression was inhibited by DMF and by dexamethasone from asthmatic and nonasthmatic ASMC, but the combination of both drugs showed no glucocorticoid sparing effect in either of the two groups. Dexamethasone 114-127 interleukin 6 Homo sapiens 38-42 19465513-7 2009 TNFalpha-induced eotaxin, RANTES, and IL-6 as well as PDGF-BB-induced IL-6 expression was inhibited by DMF and by dexamethasone from asthmatic and nonasthmatic ASMC, but the combination of both drugs showed no glucocorticoid sparing effect in either of the two groups. Dexamethasone 114-127 interleukin 6 Homo sapiens 70-74 19268915-12 2009 CONCLUSIONS: We propose a role for CSF IL-6 in the symptomatology of suicidal behavior, possibly through mechanisms involving alterations of dopamine and serotonin metabolism. Serotonin 154-163 interleukin 6 Homo sapiens 39-43 19234509-5 2009 Furthermore, reduction in OS was revealed among recipients possessing IL6 -174(*)G allele in the group of related aHSCT pairs (P=0.04). Osmium 26-28 interleukin 6 Homo sapiens 70-73 19638459-13 2009 Treatment of IL-6 increased testosterone level in LNCaP cells. Testosterone 28-40 interleukin 6 Homo sapiens 13-17 19557430-7 2009 Our findings show that (1) VSMC of progressive atheromas have the ability of differentiation, (2) that transdifferentiation and dedifferentiation phenomena are topographically diverse localized in the subregions of advanced atherosclerotic lesions, and (3) are influenced by inflammatory cytokines like IL-1beta, IL-6, and TNF-alpha. vsmc 27-31 interleukin 6 Homo sapiens 313-317 19406240-7 2009 GR function was assessed by measuring the inhibitory effect of dexamethasone on constitutive and IL-1beta-inducible IL-6 and osteoprotegerin (OPG) production. Dexamethasone 63-76 interleukin 6 Homo sapiens 116-120 19406240-8 2009 In PC-3 cells, IL-1beta stimulated IL-6 and OPG release, and dexamethasone dose-dependently inhibited IL-1beta-inducible IL-6 release, and constitutive and IL-1beta-inducible OPG release. Dexamethasone 61-74 interleukin 6 Homo sapiens 121-125 19652871-7 2009 Moreover, the formation of reactive oxygen species generated by vascular enzyme systems may play a critical role in the regulation of IL-6 indicating a cross talk between vasoactive substances i.e. angiotensin II or adrenalin and pro-inflammatory cytokines such as IL-6. Reactive Oxygen Species 27-50 interleukin 6 Homo sapiens 134-138 19652871-7 2009 Moreover, the formation of reactive oxygen species generated by vascular enzyme systems may play a critical role in the regulation of IL-6 indicating a cross talk between vasoactive substances i.e. angiotensin II or adrenalin and pro-inflammatory cytokines such as IL-6. Reactive Oxygen Species 27-50 interleukin 6 Homo sapiens 265-269 19443277-5 2009 Dual treatment of rosiglitazone and losartan provided synergistic effect in reducing ICAM-1, IL-6 and ATR1 expression and NF-kappaB and ERK1/2 activation induced by the conditioned media when compared with monotherapy. Rosiglitazone 18-31 interleukin 6 Homo sapiens 93-97 19438975-7 2009 In addition, the increase of IL-6 secretion induced by P. gingivalis infection was significantly impaired by the meiosis specific kinase 1 inhibitor, PD98059, or the nuclear factor kappaB inhibitor, Bay11-7082. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 150-157 interleukin 6 Homo sapiens 29-33 19698236-5 2009 It is concluded that cis-elements including T-Ag, PU.1, c-Ets, XPF-1, P2 alphaA, IL6-6RE and RAR may inhibit lrp16 expression and hormone or its inhibitor such as corticosteroid, tamoxifen, forskolin, phenylephrine, inflammatory factors such as IL6, IFNgamma and TNFalpha, and chemotherapeutics 5-fluorouracil may participate in the regulation of lrp16 gene expression in negative manner. Tamoxifen 179-188 interleukin 6 Homo sapiens 81-84 19477472-6 2009 After 9 months of treatment, obese children with lowered BMI SD score (SDS-BMI) displayed a significant decrease in insulin (P = .011), homeostasis model assessment of insulin resistance (P = .012), CRP (P = .006), and interleukin-6 (IL-6) (P = .045) levels compared with obese children with stable SDS-BMI; they also displayed a nonsignificant drop in sICAM levels. Sodium Dodecyl Sulfate 71-74 interleukin 6 Homo sapiens 219-232 19477472-6 2009 After 9 months of treatment, obese children with lowered BMI SD score (SDS-BMI) displayed a significant decrease in insulin (P = .011), homeostasis model assessment of insulin resistance (P = .012), CRP (P = .006), and interleukin-6 (IL-6) (P = .045) levels compared with obese children with stable SDS-BMI; they also displayed a nonsignificant drop in sICAM levels. Sodium Dodecyl Sulfate 71-74 interleukin 6 Homo sapiens 234-238 19477472-7 2009 Similarly, obese children with lowered SDS-BMI displayed a decrease in CRP (P = .005) and IL-6 (P = .065) compared with baseline levels before treatment. Sodium Dodecyl Sulfate 39-42 interleukin 6 Homo sapiens 90-94 19477472-8 2009 In the total obese group, changes in SDS-BMI correlated positively with changes in CRP (P = .035), IL-6 (P = .027), and sICAM-1 (P = .038) levels. Sodium Dodecyl Sulfate 37-40 interleukin 6 Homo sapiens 99-103 19477472-9 2009 Only SDS-BMI was an independent predictive factor for CRP (P = .031), IL-6 (P = .027), and sICAM-1 (P = .033). Sodium Dodecyl Sulfate 5-8 interleukin 6 Homo sapiens 70-74 19698236-5 2009 It is concluded that cis-elements including T-Ag, PU.1, c-Ets, XPF-1, P2 alphaA, IL6-6RE and RAR may inhibit lrp16 expression and hormone or its inhibitor such as corticosteroid, tamoxifen, forskolin, phenylephrine, inflammatory factors such as IL6, IFNgamma and TNFalpha, and chemotherapeutics 5-fluorouracil may participate in the regulation of lrp16 gene expression in negative manner. Fluorouracil 295-309 interleukin 6 Homo sapiens 81-84 19698236-5 2009 It is concluded that cis-elements including T-Ag, PU.1, c-Ets, XPF-1, P2 alphaA, IL6-6RE and RAR may inhibit lrp16 expression and hormone or its inhibitor such as corticosteroid, tamoxifen, forskolin, phenylephrine, inflammatory factors such as IL6, IFNgamma and TNFalpha, and chemotherapeutics 5-fluorouracil may participate in the regulation of lrp16 gene expression in negative manner. Fluorouracil 295-309 interleukin 6 Homo sapiens 245-248 19698236-5 2009 It is concluded that cis-elements including T-Ag, PU.1, c-Ets, XPF-1, P2 alphaA, IL6-6RE and RAR may inhibit lrp16 expression and hormone or its inhibitor such as corticosteroid, tamoxifen, forskolin, phenylephrine, inflammatory factors such as IL6, IFNgamma and TNFalpha, and chemotherapeutics 5-fluorouracil may participate in the regulation of lrp16 gene expression in negative manner. Tamoxifen 179-188 interleukin 6 Homo sapiens 245-248 19619321-15 2009 CONCLUSION: Administration of Paclitaxel to patients with high percentage Type I cancer cells could have detrimental effects due to Paclitaxel-induced enhancement of NF-kappaB and ERK activities, and cytokine production (e.g. IL-6), which promote chemoresistance and tumor progression. Paclitaxel 30-40 interleukin 6 Homo sapiens 226-230 19619321-15 2009 CONCLUSION: Administration of Paclitaxel to patients with high percentage Type I cancer cells could have detrimental effects due to Paclitaxel-induced enhancement of NF-kappaB and ERK activities, and cytokine production (e.g. IL-6), which promote chemoresistance and tumor progression. Paclitaxel 132-142 interleukin 6 Homo sapiens 226-230 19155534-9 2009 The PPAR-gamma antagonist, GW9662, significantly attenuated the inhibitory action of rosiglitazone on the increased synthesis of IL-6 and ATR1 protein. Rosiglitazone 85-98 interleukin 6 Homo sapiens 129-133 19575800-7 2009 RESULTS: For both NCI-H292 and NHBE cells, low arginine concentrations enhanced basal epithelial IL-6 and IL-8 production and synergized with TNF-alpha-induced IL-6 and IL-8 production. Arginine 47-55 interleukin 6 Homo sapiens 97-101 19575800-7 2009 RESULTS: For both NCI-H292 and NHBE cells, low arginine concentrations enhanced basal epithelial IL-6 and IL-8 production and synergized with TNF-alpha-induced IL-6 and IL-8 production. Arginine 47-55 interleukin 6 Homo sapiens 160-164 19575800-8 2009 Poly-L-arginine enhanced the stimulus-induced IL-6 and IL-8 production, however, blocking arginine uptake and the enhanced IL-6 and IL-8 production appeared unrelated. Arginine 7-15 interleukin 6 Homo sapiens 46-50 19516153-6 2009 Immediately after the third exercise bout, significant decreases for C-reactive protein (CRP), and plasma interleukin 6 (IL-6) and interleukin 10 (IL-10) were measured in Q-EGCG compared with P. Granulocyte colony-stimulating factor and CRP were reduced in Q-EGCG 14 h after exercise. q-egcg 171-177 interleukin 6 Homo sapiens 106-119 19516153-6 2009 Immediately after the third exercise bout, significant decreases for C-reactive protein (CRP), and plasma interleukin 6 (IL-6) and interleukin 10 (IL-10) were measured in Q-EGCG compared with P. Granulocyte colony-stimulating factor and CRP were reduced in Q-EGCG 14 h after exercise. q-egcg 171-177 interleukin 6 Homo sapiens 121-125 19342597-10 2009 Serial 5" deletions and site-directed mutagenesis of IL-6 promoter along with chromatin immunoprecipitation using anti-CREB antibodies showed that cAMP response element is essential for 15(S)-HETE-induced IL-6 expression. Cyclic AMP 147-151 interleukin 6 Homo sapiens 53-57 19494326-3 2009 We provide evidence that metformin attenuates the induction of EAE by restricting the infiltration of mononuclear cells into the CNS, down-regulating the expression of proinflammatory cytokines (IFN-gamma, TNF-alpha, IL-6, IL-17, and inducible NO synthase (iNOS)), cell adhesion molecules, matrix metalloproteinase 9, and chemokine (RANTES). Metformin 25-34 interleukin 6 Homo sapiens 217-221 19342597-10 2009 Serial 5" deletions and site-directed mutagenesis of IL-6 promoter along with chromatin immunoprecipitation using anti-CREB antibodies showed that cAMP response element is essential for 15(S)-HETE-induced IL-6 expression. Cyclic AMP 147-151 interleukin 6 Homo sapiens 205-209 19401270-4 2009 In these studies, the effect of 17beta-estradiol (E(2)) on the expression levels of IL-6, IL-8 and their receptors was investigated. Estradiol 32-48 interleukin 6 Homo sapiens 84-88 19344417-0 2009 Mild increases in serum hepcidin and interleukin-6 concentrations impair iron incorporation in haemoglobin during an experimental human malaria infection. Iron 73-77 interleukin 6 Homo sapiens 37-50 19344417-7 2009 We concluded that even mild increases in serum hepcidin and IL-6 concentrations result in a disturbed host iron homeostasis. Iron 107-111 interleukin 6 Homo sapiens 60-64 19401270-8 2009 Tamoxifen (Txf), an ER antagonist, completely abolished E(2)-stimulated cell growth and the expression of IL-6 and IL-8. Tamoxifen 0-9 interleukin 6 Homo sapiens 106-110 19401270-8 2009 Tamoxifen (Txf), an ER antagonist, completely abolished E(2)-stimulated cell growth and the expression of IL-6 and IL-8. Tamoxifen 11-14 interleukin 6 Homo sapiens 106-110 19401270-8 2009 Tamoxifen (Txf), an ER antagonist, completely abolished E(2)-stimulated cell growth and the expression of IL-6 and IL-8. Estradiol 56-60 interleukin 6 Homo sapiens 106-110 19401270-9 2009 IL-6/IL-8-induced cell proliferation was completely blocked by their specific neutralizing antibodies, which partially inhibited E(2)-induced cell growth. Estradiol 129-133 interleukin 6 Homo sapiens 0-4 19375766-10 2009 Insulin-induced rise in IL-6 correlated negatively to BMI (P = .001), waist to hip ratio (P = .05), and baseline (fasting) insulin (P = .03) and IL-6 (P = .02) levels and positively to insulin-stimulated glucose uptake in isolated adipocytes (P = .07). Glucose 204-211 interleukin 6 Homo sapiens 24-28 19567922-0 2009 The effect of carbohydrate ingestion on the interleukin-6 response to a 90-minute run time trial. Carbohydrates 14-26 interleukin 6 Homo sapiens 44-57 19567922-4 2009 Both high carbohydrate diets and carbohydrate ingestion during prolonged exercise have a blunting effect on IL-6 levels postendurance exercise. Carbohydrates 10-22 interleukin 6 Homo sapiens 108-112 19567922-4 2009 Both high carbohydrate diets and carbohydrate ingestion during prolonged exercise have a blunting effect on IL-6 levels postendurance exercise. Carbohydrates 33-45 interleukin 6 Homo sapiens 108-112 19567922-5 2009 We hypothesized that carbohydrate ingestion may improve performance during a prolonged bout of exercise as a consequence of a blunted IL-6 response. Carbohydrates 21-33 interleukin 6 Homo sapiens 134-138 18842114-10 2009 Log interleukin-6 was found to be significantly correlated with periodontal diagnosis, leukocyte count and level of fasting blood glucose after adjusting for the confounders (p = 0.000, p = 0.009 and p = 0.013, respectively). Glucose 130-137 interleukin 6 Homo sapiens 4-17 19885032-3 2009 In cultured Schwann cells, we noted that ERK activation is required for the serine phosphorylation of STAT3 by neuropoietic cytokine interleukin-6 (IL-6). Serine 76-82 interleukin 6 Homo sapiens 133-146 19885032-3 2009 In cultured Schwann cells, we noted that ERK activation is required for the serine phosphorylation of STAT3 by neuropoietic cytokine interleukin-6 (IL-6). Serine 76-82 interleukin 6 Homo sapiens 148-152 19885032-4 2009 Serine phosphorylated STAT3 by IL-6 was transported into Schwann cell nuclei, thereby indicating that ERK may regulate the transcriptional activity of STAT3 via the induction of serine phosphorylation of STAT3. Serine 0-6 interleukin 6 Homo sapiens 31-35 19885032-4 2009 Serine phosphorylated STAT3 by IL-6 was transported into Schwann cell nuclei, thereby indicating that ERK may regulate the transcriptional activity of STAT3 via the induction of serine phosphorylation of STAT3. Serine 178-184 interleukin 6 Homo sapiens 31-35 18798763-0 2009 Effects of tumour necrosis factor alpha and interleukin-6 on progesterone and calcium ionophore-induced acrosome reaction. Progesterone 61-73 interleukin 6 Homo sapiens 44-57 18798763-3 2009 The objective of this study was to investigate the effects of two cytokines namely tumour necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) on the spontaneous, calcium ionophore-induced and progesterone-induced human sperm AR. Calcium 169-176 interleukin 6 Homo sapiens 128-141 18798763-3 2009 The objective of this study was to investigate the effects of two cytokines namely tumour necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) on the spontaneous, calcium ionophore-induced and progesterone-induced human sperm AR. Calcium 169-176 interleukin 6 Homo sapiens 143-147 18798763-3 2009 The objective of this study was to investigate the effects of two cytokines namely tumour necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) on the spontaneous, calcium ionophore-induced and progesterone-induced human sperm AR. Progesterone 199-211 interleukin 6 Homo sapiens 128-141 18798763-3 2009 The objective of this study was to investigate the effects of two cytokines namely tumour necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) on the spontaneous, calcium ionophore-induced and progesterone-induced human sperm AR. Progesterone 199-211 interleukin 6 Homo sapiens 143-147 18798763-7 2009 Both TNF-alpha and IL-6 could decrease the spontaneous, ionophore and progesterone-induced AR (p < 0.05) in a dose-dependent manner. Progesterone 70-82 interleukin 6 Homo sapiens 19-23 18798763-9 2009 This study has demonstrated that TNF-alpha and IL-6 play a role in inhibiting both the non-physiological as well as physiologically elicited AR by calcium ionophore and progesterone respectively. Calcium 147-154 interleukin 6 Homo sapiens 47-51 18798763-9 2009 This study has demonstrated that TNF-alpha and IL-6 play a role in inhibiting both the non-physiological as well as physiologically elicited AR by calcium ionophore and progesterone respectively. Progesterone 169-181 interleukin 6 Homo sapiens 47-51 24149537-2 2009 OBJECTIVE: The effect of a potentially functional single nucleotide polymorphism (SNP) -174G/C of the IL6 gene (rs1800795) promoter was examined on maximal oxygen uptake (VO2max), body mass index (BMI) and plasma IL-6 levels in response to physical training. Oxygen 156-162 interleukin 6 Homo sapiens 102-105 19452017-10 2009 The poly(I:C)-induced expressions of IL-6 and IL-8 were down-regulated by both DEX and CsA, while the expressions of IFN-beta and TLR3 were suppressed by DEX alone. Dexamethasone 79-82 interleukin 6 Homo sapiens 37-41 19399017-6 2009 The action of IL-6 on glucose homeostasis is also complex and integrates central and peripheral mechanisms. Glucose 22-29 interleukin 6 Homo sapiens 14-18 19433247-4 2009 This review summarizes recent findings on the ability of BPA, at environmentally relevant doses, to inhibit adiponectin and stimulate the release of inflammatory adipokines such as interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFalpha) from human adipose tissue. bisphenol A 57-60 interleukin 6 Homo sapiens 181-194 19433247-4 2009 This review summarizes recent findings on the ability of BPA, at environmentally relevant doses, to inhibit adiponectin and stimulate the release of inflammatory adipokines such as interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFalpha) from human adipose tissue. bisphenol A 57-60 interleukin 6 Homo sapiens 196-200 19307187-0 2009 Interleukin-6 released from fibroblasts is essential for up-regulation of matrix metalloproteinase-1 expression by U937 macrophages in coculture: cross-talking between fibroblasts and U937 macrophages exposed to high glucose. Glucose 217-224 interleukin 6 Homo sapiens 0-13 19307187-10 2009 In conclusion, this study demonstrates that IL-6 derived from fibroblasts is essential for MMP-1 up-regulation by cross-talking between fibroblasts and U937 macrophages exposed to high glucose, revealing an IL-6-dependent mechanism in MMP-1 up-regulation. Glucose 185-192 interleukin 6 Homo sapiens 44-48 19307187-10 2009 In conclusion, this study demonstrates that IL-6 derived from fibroblasts is essential for MMP-1 up-regulation by cross-talking between fibroblasts and U937 macrophages exposed to high glucose, revealing an IL-6-dependent mechanism in MMP-1 up-regulation. Glucose 185-192 interleukin 6 Homo sapiens 207-211 19464661-7 2009 Furthermore, TP-mediated phosphoinositide hydrolysis, phosphorylation of extracellular signal-regulated kinase (ERK) 1/2 and interleukin-6 production were reduced by the expression of KIAA1005/TPIP. neotetrazolium 13-15 interleukin 6 Homo sapiens 125-138 18597869-0 2009 Metformin inhibits TNF-alpha-induced IkappaB kinase phosphorylation, IkappaB-alpha degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation. Metformin 0-9 interleukin 6 Homo sapiens 99-103 18597869-7 2009 Pre-treatment with metformin (100-1000 micromol/L) also inhibited TNF-alpha-induced IL-6 production, phosphorylation of IkappaB kinase (IKK) alpha/beta and IkappaB-alpha degradation. Metformin 19-28 interleukin 6 Homo sapiens 84-88 18597869-10 2009 Transfection of siRNA against alpha1-AMPK eradicated the inhibitory effects of metformin on TNF-alpha-induced IL-6, implying the essential role of AMPK. Metformin 79-88 interleukin 6 Homo sapiens 110-114 18597869-11 2009 CONCLUSIONS: Metformin had anti-inflammatory effects on endothelial cells and inhibited TNF-alpha-induced IKKalpha/beta phosphorylation, IkappaB-alpha degradation and IL-6 production in HUVEC. Metformin 13-22 interleukin 6 Homo sapiens 167-171 19279008-5 2009 Knockdown of GBA1 also evoked the hyperproduction of IL-6 in response to 4beta phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 73-110 interleukin 6 Homo sapiens 53-57 19321461-12 2009 Moreover, activated Vitamin D enhanced the development of IL-10 producing cells, and reduced the number of IL-6 and IL-17 secreting cells. Vitamin D 20-29 interleukin 6 Homo sapiens 107-111 19285962-0 2009 Capsaicin inhibits the IL-6/STAT3 pathway by depleting intracellular gp130 pools through endoplasmic reticulum stress. Capsaicin 0-9 interleukin 6 Homo sapiens 23-27 19285962-2 2009 It was recently reported that capsaicin inhibited interleukin-6 (IL-6)-induced activation of signal transducer and activator of transcription 3 (STAT3), an anti-apoptotic transcription factor. Capsaicin 30-39 interleukin 6 Homo sapiens 50-63 19285962-2 2009 It was recently reported that capsaicin inhibited interleukin-6 (IL-6)-induced activation of signal transducer and activator of transcription 3 (STAT3), an anti-apoptotic transcription factor. Capsaicin 30-39 interleukin 6 Homo sapiens 65-69 19285962-3 2009 Here we demonstrate that capsaicin induced downregulation of the IL-6 receptor gp130 within 2h in glial tumors. Capsaicin 25-34 interleukin 6 Homo sapiens 65-69 19285962-6 2009 The depletion of the intracellular pool of gp130 by capsaicin and an ER stress inducer led to an immediate loss of the IL-6 response due to the short half-life of membrane localized gp130. Capsaicin 52-61 interleukin 6 Homo sapiens 119-123 19344406-0 2009 Targeted inhibition of interleukin-6 with CNTO 328 sensitizes pre-clinical models of multiple myeloma to dexamethasone-mediated cell death. Dexamethasone 105-118 interleukin 6 Homo sapiens 23-36 19344406-3 2009 CNTO 328 potently increased the cytotoxicity of dex in IL-6-dependent and -independent human myeloma cell lines (HMCLs), including a bortezomib-resistant HMCL. Dexamethasone 48-51 interleukin 6 Homo sapiens 55-59 19325469-11 2009 The patients from the hydrocortisone group (n = 19) had significantly lower levels of IL-6 and higher levels of IL-10, resulting in an attenuated change in IL-6/IL-10 ratio (28.7 [6.4/128.7] vs. 292.8 [6.5/534.6] 4 hours after cardiopulmonary bypass; p < 0.001). Hydrocortisone 22-36 interleukin 6 Homo sapiens 156-160 19325469-0 2009 Stress doses of hydrocortisone in high-risk patients undergoing cardiac surgery: effects on interleukin-6 to interleukin-10 ratio and early outcome. Hydrocortisone 16-30 interleukin 6 Homo sapiens 92-105 19325469-13 2009 CONCLUSIONS: Stress doses of hydrocortisone attenuate the evolution of IL-6/IL-10 ratio in patients with systemic inflammatory response syndrome after CS, which seems to be associated with an improved outcome. Hydrocortisone 29-43 interleukin 6 Homo sapiens 71-75 19325469-4 2009 OBJECTIVE: To evaluate immunologic effects (especially IL-6 to IL-10 ratio) of stress doses of hydrocortisone in a high-risk group of patients after cardiac surgery with cardiopulmonary bypass. Hydrocortisone 95-109 interleukin 6 Homo sapiens 55-59 19325469-11 2009 The patients from the hydrocortisone group (n = 19) had significantly lower levels of IL-6 and higher levels of IL-10, resulting in an attenuated change in IL-6/IL-10 ratio (28.7 [6.4/128.7] vs. 292.8 [6.5/534.6] 4 hours after cardiopulmonary bypass; p < 0.001). Hydrocortisone 22-36 interleukin 6 Homo sapiens 86-90 19325469-14 2009 The immunologic effects of hydrocortisone may thus be both, inhibitory (IL-6) and permissive (IL-10), regarding the immune response. Hydrocortisone 27-41 interleukin 6 Homo sapiens 72-76 19461187-0 2009 A case of acute promyelocytic leukemia showing transient thrombocytosis caused by increased interleukin-6 and thrombopoietin after treatment with all-trans retinoic acid and chemotherapy. Tretinoin 156-169 interleukin 6 Homo sapiens 92-105 19188427-2 2009 We hypothesized that IL-6 promotes endothelial cell signaling and capillary recruitment in vivo, contributing to increased glucose uptake. Glucose 123-130 interleukin 6 Homo sapiens 21-25 19188427-6 2009 In contrast, IL-6 increased Akt phosphorylation (Ser473) in hindlimb skeletal muscle and enhanced whole-body glucose disappearance and glucose uptake during the clamp. Glucose 109-116 interleukin 6 Homo sapiens 13-17 19188427-6 2009 In contrast, IL-6 increased Akt phosphorylation (Ser473) in hindlimb skeletal muscle and enhanced whole-body glucose disappearance and glucose uptake during the clamp. Glucose 135-142 interleukin 6 Homo sapiens 13-17 19461187-5 2009 These findings suggest that in APL patients, thrombocytosis after treatment with ATRA and or chemotherapy may be caused by increased plasma levels of both of IL-6 and TPO. Tretinoin 81-85 interleukin 6 Homo sapiens 158-170 19410080-5 2009 We also found that LPS-induced expression of COX-2, IL-6, and TNF-alpha and p38 activation were markedly suppressed when LPS was pretreated with ozonated water. Water 154-159 interleukin 6 Homo sapiens 52-56 19416633-6 2009 Resveratrol significantly inhibited the PMA plus A23187-induction of inflammatory cytokines such as tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-8. Tetradecanoylphorbol Acetate 40-43 interleukin 6 Homo sapiens 136-154 19721908-8 2009 Two patients presented a bad evolution; they received 4.2 and 5.2 md/d of Zn and showed an increase of IL6 levels, maintained high levels of IL6sR but C-RP levels decreased. Zinc 74-76 interleukin 6 Homo sapiens 103-106 19416633-6 2009 Resveratrol significantly inhibited the PMA plus A23187-induction of inflammatory cytokines such as tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-8. Resveratrol 0-11 interleukin 6 Homo sapiens 136-154 19416633-10 2009 Resveratrol suppressed the expression of TNF-alpha, IL-6, IL-8 and COX-2 through a decrease in the intracellular levels of Ca2+ and ERK 1/2, as well as activation of NF-kappaB. Resveratrol 0-11 interleukin 6 Homo sapiens 52-56 18804762-7 2009 The association between IL-6 and CAC was largely in those with lower (below the median) abdominal artery calcium (AAC) levels (p=0.04). Calcium 105-112 interleukin 6 Homo sapiens 24-28 18187214-7 2009 RESULTS: Atorvastatin induced a decrease of IL-6 at 1 week, an effect which reached significance compared to baseline at 6 weeks post STEMI (p<0.05 vs baseline). Atorvastatin 9-21 interleukin 6 Homo sapiens 44-48 18187214-11 2009 CONCLUSION: Early initiation of low-dose atorvastatin treatment decreases the expression of IL-6 and sVCAM-1 and the release of vWF in patients with STEMI. Atorvastatin 41-53 interleukin 6 Homo sapiens 92-96 19201813-8 2009 Collectively, our data for the first time suggest a dual role of ozone in modulating IL-6 secretion and TEER outcomes in a PGE(2)-dependent (in presence of TNF stimulus) and -independent manner (in absence of cytokine stimulus). Ozone 65-70 interleukin 6 Homo sapiens 85-89 19201813-0 2009 Ozone modulates IL-6 secretion in human airway epithelial and smooth muscle cells. Ozone 0-5 interleukin 6 Homo sapiens 16-20 18824040-7 2009 Cortisol treatment reduced retrieval of neutral and emotional words (marginally significant at p=0.07), and significantly reduced stimulated IL-6 production (p<0.001). Hydrocortisone 0-8 interleukin 6 Homo sapiens 141-145 19019580-9 2009 CSF lactate was correlated with CSF concentrations of IL-1beta, IL-6, GM-CSF, G-CSF, IFN-gamma and MIP-1beta. Lactic Acid 4-11 interleukin 6 Homo sapiens 64-68 18820825-6 2009 Treatment with pioglitazone, associated with metformin, showed a reduction of IL-6 monocyte production after their in vitro activation with LPS. Metformin 45-54 interleukin 6 Homo sapiens 78-82 19038492-2 2009 Recent reports show that phosphorylation of p65 at serine 276 regulates only a subset of genes, such as those encoding IL-6, IL-8, Gro-beta, and ICAM-1. Serine 51-57 interleukin 6 Homo sapiens 119-123 19252469-4 2009 SP stimulates the production of hematopoietic cytokines (e.g. IL-1, IL-3, IL-6, SCF, GM-CSF) by bone marrow stromal cells. TFF2 protein, human 0-2 interleukin 6 Homo sapiens 74-78 18336871-6 2009 Interleukin-6 appears to be the central mediator of anemia of chronic disease in a range of inflammatory diseases, including end-stage renal disease and rheumatoid arthritis, through increased generation of hepcidin and the resultant alterations in iron metabolism. Iron 249-253 interleukin 6 Homo sapiens 0-13 19135383-4 2009 We found that LPIL exerted a smaller effect on gene transcription than Dex; however, IL-1beta-inducible target genes such as the CXCL type chemokines IL-8, IL-1beta and IL-6 were all clearly suppressed by LPIL to the same degree as by Dex. Dexamethasone 235-238 interleukin 6 Homo sapiens 169-173 19167238-4 2009 Endotoxin administration alone induced a 3-, 12- and 5-fold increase in plasma concentrations of TNF-alpha, IL-6 and IL-10, respectively, 3h after LPS challenge. Tritium 138-140 interleukin 6 Homo sapiens 108-112 18587580-4 2009 These studies demonstrated that CDDO-Me significantly inhibits IL-6 secretion in paclitaxel-resistant ovarian cancer cells and specifically suppresses IL-6- or oncostatin M-induced Stat3 nuclear translocation. Paclitaxel 81-91 interleukin 6 Homo sapiens 63-67 19011039-5 2009 In MDA PCa 2b cells, growth stimulation by IL-6 was reversed by administration of either the non-steroidal anti-androgen bicalutamide or the inhibitor of the mitogen-activated protein kinase pathway PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 199-206 interleukin 6 Homo sapiens 43-47 19182994-4 2009 Interleukin-6 (IL-6)-induced phosphorylation of tyrosine-705 and serine-727, as well as DNA-binding and transcriptional activity of Stat3 were further enhanced by Ha-ras overexpression. Tyrosine 48-56 interleukin 6 Homo sapiens 0-13 19182994-4 2009 Interleukin-6 (IL-6)-induced phosphorylation of tyrosine-705 and serine-727, as well as DNA-binding and transcriptional activity of Stat3 were further enhanced by Ha-ras overexpression. Tyrosine 48-56 interleukin 6 Homo sapiens 15-19 19182994-4 2009 Interleukin-6 (IL-6)-induced phosphorylation of tyrosine-705 and serine-727, as well as DNA-binding and transcriptional activity of Stat3 were further enhanced by Ha-ras overexpression. Serine 65-71 interleukin 6 Homo sapiens 0-13 19182994-4 2009 Interleukin-6 (IL-6)-induced phosphorylation of tyrosine-705 and serine-727, as well as DNA-binding and transcriptional activity of Stat3 were further enhanced by Ha-ras overexpression. Serine 65-71 interleukin 6 Homo sapiens 15-19 19092166-9 2009 Elevated fasting glucose (>6.2 mmol/l) markedly increased the predictive power of inflammatory markers (IL-18: 5.5 [1.4-21.1], IL-6: 3.5 [1.0-11.8], and CRP: 3.5 [1.0-11.9]). Glucose 17-24 interleukin 6 Homo sapiens 130-134 18988672-5 2009 Under these conditions there was a marked reduction in IL-6-dependent STAT3 signaling, including decreased STAT3 tyrosine phosphorylation, loss in nuclear accumulation of STAT3, and impaired expression of target genes, such as fibrinogen-gamma. Tyrosine 113-121 interleukin 6 Homo sapiens 55-59 19171135-6 2009 Endothelin-1-induced IL-6 production was markedly attenuated by EGTA and various Ca(2+) channel inhibitors such as 3,5-bis(trifluoromethyl)-1H-pyrazole derivative (BTP-2), 1-[beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole hydrochloride (SKF96365), and nifedipine. Egtazic Acid 64-68 interleukin 6 Homo sapiens 21-25 19171135-6 2009 Endothelin-1-induced IL-6 production was markedly attenuated by EGTA and various Ca(2+) channel inhibitors such as 3,5-bis(trifluoromethyl)-1H-pyrazole derivative (BTP-2), 1-[beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole hydrochloride (SKF96365), and nifedipine. 3,5-Bis(trifluoromethyl)-1H-pyrazole 115-151 interleukin 6 Homo sapiens 21-25 19171135-6 2009 Endothelin-1-induced IL-6 production was markedly attenuated by EGTA and various Ca(2+) channel inhibitors such as 3,5-bis(trifluoromethyl)-1H-pyrazole derivative (BTP-2), 1-[beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole hydrochloride (SKF96365), and nifedipine. 1-[beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1h-imidazole hydrochloride 172-255 interleukin 6 Homo sapiens 21-25 19144759-4 2009 Independent of age, serum creatinine, and sexual hormone binding globulin (SHBG), testosterone levels inversely and strongly associated with the inflammatory markers IL-6 and CRP. Testosterone 82-94 interleukin 6 Homo sapiens 166-170 19318315-5 2009 In addition, the stimulation of IL-6 production by IL-17 in MSC cultures and co-cultures is enhanced by low O2 concentration. Oxygen 108-110 interleukin 6 Homo sapiens 32-36 19218094-8 2009 Cells cultured in a medium with glucose 30 mmol/L generated more free radicals (+20%, P < 0.05) and released more MCP-1 (+113%, P < 0.001) and IL-6 (+26%, P < 0.05). Glucose 32-39 interleukin 6 Homo sapiens 149-153 18825409-9 2009 Pretreatment of cells with SB203580 (inhibitor of p38) and PD98059 (inhibitor of ERK) attenuated LPS-induced IL-6 expression, whereas LY294002 (inhibitor of PI3K) markedly amplified the LPS-stimulated synthesis of IL-6. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 59-66 interleukin 6 Homo sapiens 109-113 19101504-5 2009 Expression levels of IL-6, bFGF, and GRO in cultured NP were downregulated by dexamethasone (DEX) treatment, while MCP-1 expression was not suppressed. Dexamethasone 78-91 interleukin 6 Homo sapiens 21-25 19101504-5 2009 Expression levels of IL-6, bFGF, and GRO in cultured NP were downregulated by dexamethasone (DEX) treatment, while MCP-1 expression was not suppressed. Dexamethasone 93-96 interleukin 6 Homo sapiens 21-25 19185102-11 2009 Neonates delivered in the context of intraamniotic inflammation had higher serum blood urea nitrogen levels, which correlated significantly with AF IL-6 levels. Urea 87-91 interleukin 6 Homo sapiens 148-152 19118524-3 2009 In this study, we report that two synthetic FXR agonists, WAY-362450 and GW4064, suppressed interleukin-6-induced CRP expression in human Hep3B hepatoma cells. GW 4064 73-79 interleukin 6 Homo sapiens 92-105 19175577-10 2009 Only IL-6 was significantly higher in the LPS Propofol(sulfite) group compared with both the Ket/Mid group and the Propofol(EDTA) group. Sulfites 55-62 interleukin 6 Homo sapiens 5-9 19185102-11 2009 Neonates delivered in the context of intraamniotic inflammation had higher serum blood urea nitrogen levels, which correlated significantly with AF IL-6 levels. Nitrogen 92-100 interleukin 6 Homo sapiens 148-152 19074641-0 2009 Effect of curcumin on acidic pH-induced expression of IL-6 and IL-8 in human esophageal epithelial cells (HET-1A): role of PKC, MAPKs, and NF-kappaB. Curcumin 10-18 interleukin 6 Homo sapiens 54-58 19074641-6 2009 Curcumin, as well as inhibitors of NF-kappaB (SN-50), PKC (chelerythrine), and p44/42 MAPK (PD-098059) abolished the acid-induced expression of IL-6 and IL-8. Curcumin 0-8 interleukin 6 Homo sapiens 144-148 19074641-9 2009 Together, these data demonstrate that 1) acid is a potent inducer of IL-6 and IL-8 production in HET-1A cells; 2) MAPK and PKC signaling play a key regulatory role in acid-mediated IL-6 and IL-8 expression via NF-kappaB activation; and 3) the anti-inflammatory plant compound curcumin inhibits esophageal activation in response to acid. Curcumin 276-284 interleukin 6 Homo sapiens 181-185 19221248-10 2009 Curcumin treatment resulted in inhibition of IKK activity and inhibition of IL-6 and IL-8 expression. Curcumin 0-8 interleukin 6 Homo sapiens 76-80 19180509-7 2009 PGE(2) titration combined with interleukin-1 (IL-1) synergistically accelerated expression of pain-associated molecules such as inducible nitric oxide synthase and IL-6. Dinoprostone 0-5 interleukin 6 Homo sapiens 164-168 19221248-11 2009 CONCLUSIONS: Curcumin significantly reduces IL-6 and IL-8 levels in HNSCC cell lines. Curcumin 13-21 interleukin 6 Homo sapiens 44-48 19221248-0 2009 Suppression of interleukin 6 and 8 production in head and neck cancer cells with curcumin via inhibition of Ikappa beta kinase. Curcumin 81-89 interleukin 6 Homo sapiens 15-28 19221248-1 2009 OBJECTIVES: To evaluate the effect of curcumin on production of interleukin 6 (IL-6) and 8 (IL-8) in head and neck squamous cell carcinoma (HNSCC) cell lines and to determine the mechanism by which these effects are modulated. Curcumin 38-46 interleukin 6 Homo sapiens 64-77 18631417-7 2009 DHA (400 microm) resulted in a significant 16% reduction in IL-6 release after RV-43 infection, 29% reduction in IL-6 release after RV-1B infection, 28% reduction in IP-10 release after RV-43 infection and 23 % reduction in IP-10 release after RV-1B infection. dehydroacetic acid 0-3 interleukin 6 Homo sapiens 60-64 19221248-1 2009 OBJECTIVES: To evaluate the effect of curcumin on production of interleukin 6 (IL-6) and 8 (IL-8) in head and neck squamous cell carcinoma (HNSCC) cell lines and to determine the mechanism by which these effects are modulated. Curcumin 38-46 interleukin 6 Homo sapiens 79-83 19221248-7 2009 MAIN OUTCOME MEASURES: Reverse transcription-polymerase chain reaction was performed to determine the effect of curcumin on the expression of IL-6 and IL-8. Curcumin 112-120 interleukin 6 Homo sapiens 142-146 19221248-8 2009 RESULTS: Curcumin treatment resulted in dose-dependent inhibition of IL-6 and IL-8 in all cell lines. Curcumin 9-17 interleukin 6 Homo sapiens 69-73 18835437-7 2009 In the vaccine/stress group, participants with larger IL-6 responses had heightened systolic blood pressure responses to tasks and elevated post-stress salivary levels of the noradrenaline metabolite 3-methoxy-phenyl glycol (MHPG) and cortisol. Norepinephrine 175-188 interleukin 6 Homo sapiens 54-58 18835437-7 2009 In the vaccine/stress group, participants with larger IL-6 responses had heightened systolic blood pressure responses to tasks and elevated post-stress salivary levels of the noradrenaline metabolite 3-methoxy-phenyl glycol (MHPG) and cortisol. Hydrocortisone 235-243 interleukin 6 Homo sapiens 54-58 18631417-7 2009 DHA (400 microm) resulted in a significant 16% reduction in IL-6 release after RV-43 infection, 29% reduction in IL-6 release after RV-1B infection, 28% reduction in IP-10 release after RV-43 infection and 23 % reduction in IP-10 release after RV-1B infection. dehydroacetic acid 0-3 interleukin 6 Homo sapiens 113-117 18996182-0 2009 Norepinephrine upregulates VEGF, IL-8, and IL-6 expression in human melanoma tumor cell lines: implications for stress-related enhancement of tumor progression. Norepinephrine 0-14 interleukin 6 Homo sapiens 43-47 18631417-8 2009 Cellular DHA content negatively correlated with IL-6 and IP-10 release. dehydroacetic acid 9-12 interleukin 6 Homo sapiens 48-52 19138532-3 2009 The results revealed that DEX nonspecifically and dose-dependently inhibited the production of 12 cytokines (IL-2, IFN-gamma, TNF-alpha, IL-8, IL-1beta, IL-17, IL-4, IL-5, IL-6, IL-10, IL-13, and G-CSF). Dexamethasone 26-29 interleukin 6 Homo sapiens 172-176 19165670-5 2009 Moreover, plasma levels of 8-isoprostane, not MDA, were significantly correlated with the plasma levels of hs-CRP, IL-6, and TNF-alpha in patients with PE. 8-epi-prostaglandin F2alpha 27-40 interleukin 6 Homo sapiens 115-119 19046877-8 2009 Since paclitaxel has been shown to induce the expression of inflammatory genes in monocytes and tumour cells, we tested whether paclitaxel could influence IL-6 and IL-1beta release from the cells used in this paper. Paclitaxel 128-138 interleukin 6 Homo sapiens 155-159 18992263-7 2009 Most associations varied by recent aspirin/NSAID use: IL6 rs1800796 and rs1800795 polymorphisms were associated inversely with tumor mutations in the presence of aspirin/NSAIDs; POMC significantly reduced risk of Ki-ras-mutated tumors when aspirin/NSAIDs were not used; the TCF7L2 rs7903146 was associated with reduced risk of Ki-ras-mutated tumors in the presence of aspirin and increased risk in the absence of aspirin. Aspirin 35-42 interleukin 6 Homo sapiens 54-57 19050054-6 2009 RESULTS: In age-adjusted analysis, log (E2) was positively associated with log (IL-6) (r = 0.19; P = 0.047), and the relationship was statistically significant (P = 0.032) after adjustments for age, BMI, smoking, physical activity, chronic disease, and serum testosterone levels. Testosterone 259-271 interleukin 6 Homo sapiens 80-84 18776171-3 2009 RSV blocked 10,12 CLA induction of the inflammatory response by preventing activation of extracellular signal-related kinase and induction of inflammatory gene expression (i.e., IL-6, IL-8, IL-1beta) within 12 h. Similarly, RSV suppressed 10,12 CLA-mediated activation of the inflammatory prostaglandin pathway involving phospholipase A(2), cyclooxygenase-2, and PGF(2alpha). Resveratrol 0-3 interleukin 6 Homo sapiens 178-182 17629591-4 2009 In addition, we demonstrated that Hsp20, HspB2 and HspB8 induced interleukin-6 production in cultured pericytes and astrocytes, which could be antagonized by dexamethasone, whereas other sHsps and A beta were inactive, suggesting that sHsps may be among the key mediators of the local inflammatory response associated with HCHWA-D and AD lesions. Dexamethasone 158-171 interleukin 6 Homo sapiens 65-78 19061939-3 2009 We previously indicated that exogenous IL-6 protected neurons against glutamate and N-methyl-d-aspartate (NMDA) attacks and the effects of IL-6 was blocked by anti-gp130 antibody. Glutamic Acid 70-79 interleukin 6 Homo sapiens 39-43 19061939-10 2009 IL-6-induced STAT3 phosphorylation was inhibited by AG490 but not by PD98059; and IL-6-induced ERK1/2 activation was blocked by PD98059 but not by AG490. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 128-135 interleukin 6 Homo sapiens 0-4 19061939-10 2009 IL-6-induced STAT3 phosphorylation was inhibited by AG490 but not by PD98059; and IL-6-induced ERK1/2 activation was blocked by PD98059 but not by AG490. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 128-135 interleukin 6 Homo sapiens 82-86 19061939-11 2009 Either AG490 or PD98059 blocked the IL-6 protection against the NMDA-elicited neuronal vitality decrease and caspase-3 activation increase. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 16-23 interleukin 6 Homo sapiens 36-40 19174069-2 2009 The aim of our study was to evaluate the effect of enteral nutrition supplemented with a high dose of arginine on c-reactive protein (CRP), interleukin 6 (IL6) and tumoral necrosis factor (TNF alpha) in surgical head and neck cancer patients. Arginine 102-110 interleukin 6 Homo sapiens 140-153 19181644-7 2009 RESULTS: In vitro, IL-1Ra was superior to dexamethasone at inhibiting IL-6 production; maximal IL-6 inhibition and apoptosis induction were achieved by addition of both IL-1Ra and dexamethasone. Dexamethasone 42-55 interleukin 6 Homo sapiens 70-74 19181644-7 2009 RESULTS: In vitro, IL-1Ra was superior to dexamethasone at inhibiting IL-6 production; maximal IL-6 inhibition and apoptosis induction were achieved by addition of both IL-1Ra and dexamethasone. Dexamethasone 180-193 interleukin 6 Homo sapiens 95-99 18992263-7 2009 Most associations varied by recent aspirin/NSAID use: IL6 rs1800796 and rs1800795 polymorphisms were associated inversely with tumor mutations in the presence of aspirin/NSAIDs; POMC significantly reduced risk of Ki-ras-mutated tumors when aspirin/NSAIDs were not used; the TCF7L2 rs7903146 was associated with reduced risk of Ki-ras-mutated tumors in the presence of aspirin and increased risk in the absence of aspirin. Aspirin 162-169 interleukin 6 Homo sapiens 54-57 18992263-7 2009 Most associations varied by recent aspirin/NSAID use: IL6 rs1800796 and rs1800795 polymorphisms were associated inversely with tumor mutations in the presence of aspirin/NSAIDs; POMC significantly reduced risk of Ki-ras-mutated tumors when aspirin/NSAIDs were not used; the TCF7L2 rs7903146 was associated with reduced risk of Ki-ras-mutated tumors in the presence of aspirin and increased risk in the absence of aspirin. Aspirin 162-169 interleukin 6 Homo sapiens 54-57 18992263-7 2009 Most associations varied by recent aspirin/NSAID use: IL6 rs1800796 and rs1800795 polymorphisms were associated inversely with tumor mutations in the presence of aspirin/NSAIDs; POMC significantly reduced risk of Ki-ras-mutated tumors when aspirin/NSAIDs were not used; the TCF7L2 rs7903146 was associated with reduced risk of Ki-ras-mutated tumors in the presence of aspirin and increased risk in the absence of aspirin. Aspirin 162-169 interleukin 6 Homo sapiens 54-57 18992263-7 2009 Most associations varied by recent aspirin/NSAID use: IL6 rs1800796 and rs1800795 polymorphisms were associated inversely with tumor mutations in the presence of aspirin/NSAIDs; POMC significantly reduced risk of Ki-ras-mutated tumors when aspirin/NSAIDs were not used; the TCF7L2 rs7903146 was associated with reduced risk of Ki-ras-mutated tumors in the presence of aspirin and increased risk in the absence of aspirin. Aspirin 162-169 interleukin 6 Homo sapiens 54-57 18752089-2 2009 AIMS: This joint analysis aimed to clarify whether IL6 -174G>C was associated with glucose and circulating interleukin-6 concentrations as well as body mass index (BMI). Glucose 86-93 interleukin 6 Homo sapiens 51-54 18948687-8 2009 However, in linear regression, change in interleukin-6 was correlated with change in creatinine. Creatinine 85-95 interleukin 6 Homo sapiens 41-54 18617679-5 2009 Pretreatment with N-acetylcysteine (NAC) or EUK-134, in a dose-dependent manner, attenuated PM-induced ROS production, COX-2 expression, and IL-6 release. Acetylcysteine 18-34 interleukin 6 Homo sapiens 141-145 18617679-5 2009 Pretreatment with N-acetylcysteine (NAC) or EUK-134, in a dose-dependent manner, attenuated PM-induced ROS production, COX-2 expression, and IL-6 release. Acetylcysteine 36-39 interleukin 6 Homo sapiens 141-145 18752089-6 2009 IL6 -174 C-allele carriers had significantly lower fasting glucose (-0.091 mmol/L, P=0.014). Glucose 59-66 interleukin 6 Homo sapiens 0-3 18752089-8 2009 CONCLUSIONS: Our data suggest that C-allele carriers of the IL6 -174G>C polymorphism have lower fasting glucose levels on average, which substantiates previous findings of decreased T2DM risk of these subjects. Glucose 107-114 interleukin 6 Homo sapiens 60-63 19201396-4 2009 Western blotting analysis using monoclonal antibody against IL-6 or gp 130 verified that this IL-6-driven activity was through the activation of tyrosine phosphorylation (Tyr(705)) of STAT3 in cancer cells. Tyrosine 145-153 interleukin 6 Homo sapiens 60-64 19118018-8 2009 IL-6 induced the expression of cyclooxygenase-2 in neuroblastoma cells with concomitant release of prostaglandin-E2, which increased the expression of IL-6 by BMSC. Dinoprostone 99-115 interleukin 6 Homo sapiens 0-4 19118018-8 2009 IL-6 induced the expression of cyclooxygenase-2 in neuroblastoma cells with concomitant release of prostaglandin-E2, which increased the expression of IL-6 by BMSC. Dinoprostone 99-115 interleukin 6 Homo sapiens 151-155 19201396-4 2009 Western blotting analysis using monoclonal antibody against IL-6 or gp 130 verified that this IL-6-driven activity was through the activation of tyrosine phosphorylation (Tyr(705)) of STAT3 in cancer cells. Tyrosine 145-153 interleukin 6 Homo sapiens 94-98 19201396-4 2009 Western blotting analysis using monoclonal antibody against IL-6 or gp 130 verified that this IL-6-driven activity was through the activation of tyrosine phosphorylation (Tyr(705)) of STAT3 in cancer cells. Tyrosine 171-174 interleukin 6 Homo sapiens 60-64 19201396-4 2009 Western blotting analysis using monoclonal antibody against IL-6 or gp 130 verified that this IL-6-driven activity was through the activation of tyrosine phosphorylation (Tyr(705)) of STAT3 in cancer cells. Tyrosine 171-174 interleukin 6 Homo sapiens 94-98 20046945-5 2009 The GSH-AuNP immunosensor gave a detection limit (DL) of 10 pg mL(-1) IL-6 (500 amol mL(-1)) in 10 muL calf serum, which was 3-fold better than 30 pg mL(-1) found for the SWNT forest immunosensor for the same assay protocol. Glutathione 4-7 interleukin 6 Homo sapiens 70-74 19641312-4 2009 RESULTS: An increase in IL-6 level was found in the aspirin group when compared to the triflusal group at the third and seventh day (p < 0.05). Aspirin 52-59 interleukin 6 Homo sapiens 24-28 18973470-3 2009 show that a 4-week treatment course with the lipophilic statin atorvastatin ameliorates left ventricular remodelling and function, reduces serum levels of TNF-alpha (tumour necrosis factor-alpha), IL (interleukin)-6 and MCP-1 (monocyte chemoattractant protein-1), and increases both serum and myocardial levels of IL-10. Atorvastatin 63-75 interleukin 6 Homo sapiens 197-215 19156623-5 2009 In glucose-intolerant subjects, sCD36 was negatively associated with insulin sensitivity and positively with interleukin-6 (IL-6), fasting glucose, fasting triglycerides, fat-free mass and platelet count. Glucose 3-10 interleukin 6 Homo sapiens 109-122 19641312-9 2009 CONCLUSION: Triflusal modulates additional mechanisms to those of aspirin [pro-inflammatory (IL-6) and chemokine (MIP-1 and MCP-1) pathways] that could participate in the ischemic damage process following human acute stroke. Aspirin 66-73 interleukin 6 Homo sapiens 93-97 19136878-9 2009 White blood cells and IL-6 might be involved in inflammatory process of zinc fume exposure with zinc and copper increasing GSH, but nickel depleting it. Copper 105-111 interleukin 6 Homo sapiens 22-26 19494504-11 2009 Eotaxin-induced production of IL-1beta, IL-6, and MIP-1beta was significantly reduced by the MEK inhibitor PD98059, p38 MAPK inhibitor SB203580, or PI3K inhibitor LY294002. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 107-114 interleukin 6 Homo sapiens 40-44 20375612-11 2009 Taken together, we demonstrate a constitutive NOX4-dependent ROS generation in a microglial cell line which leads to expression of IL-6 mRNA. Reactive Oxygen Species 61-64 interleukin 6 Homo sapiens 131-135 19439970-5 2009 RESULTS: A significant correlation between norepinephrine support and IL-6 plasma concentrations was shown at the separation from CPB (k = 0.742) and 12 h after it (k = 0.801) as well as between norepinephrine support and IL-8 concentrations 12 h after the separation from CPB. Norepinephrine 43-57 interleukin 6 Homo sapiens 70-74 19027816-6 2009 Resveratrol treatment effectively prevented increased production of intracellular reactive oxygen species (iROS) and inflammatory markers (IL1alpha, IL6, IL8, and ELAM-1), and reduced expression of the senescence markers sa-beta-gal, lipofuscin, and accumulation of carbonylated proteins. Resveratrol 0-11 interleukin 6 Homo sapiens 149-152 19188739-4 2009 After 6 weeks of metformin therapy (n = 37) there was a significant reduction in BMI (p < 0.001), waist (p < 0.001) and CRP (p < 0.01), while at 6 months there was not only a significant reduction in BMI and waist but also in HOMA-R (p = 0.01) and IL-6 levels (p < 0.01) with no further reduction of CRP. Metformin 17-26 interleukin 6 Homo sapiens 257-261 19188739-7 2009 Metformin-associated reduction of CRP levels prior to any significant changes in insulin resistance or IL-6 perhaps involves different mechanisms of action. Metformin 0-9 interleukin 6 Homo sapiens 103-107 19136878-9 2009 White blood cells and IL-6 might be involved in inflammatory process of zinc fume exposure with zinc and copper increasing GSH, but nickel depleting it. Glutathione 123-126 interleukin 6 Homo sapiens 22-26 18971377-3 2009 Using immunocytochemistry, Western blot, and patch-clamp recording, we demonstrate that H-IL-6 induces the differentiation of neural stem cells (NSCs) specifically into glutamate-responsive neurons and two morphological distinctive astroglia cell types. Glutamic Acid 169-178 interleukin 6 Homo sapiens 90-94 18515973-9 2009 7-Ketocholesterol also enhanced IL-6 release from VSMC. vsmc 50-54 interleukin 6 Homo sapiens 32-36 18971377-4 2009 H-IL-6-activated neurogenesis seems to be induced by the MAPK/CREB (mitogen-activated protein kinase/cAMP response element-binding protein) cascade, whereas gliogenesis is mediated via the STAT-3 (signal transducers and activators of transcription protein-3) signaling pathway. Cyclic AMP 101-105 interleukin 6 Homo sapiens 2-6 19365148-6 2009 GC sensitivity was assessed in vitro as the ability of DEX to inhibit lipopolysaccharide-stimulated production of the cytokines interleukin 1-beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in a whole-blood assay. Dexamethasone 55-58 interleukin 6 Homo sapiens 159-172 19139110-8 2009 INCB20 also abrogated the protective effect of IL-6 against dexamethasone by blocking phosphorylation of SHP-2 and AKT. Dexamethasone 60-73 interleukin 6 Homo sapiens 47-51 19365148-7 2009 RESULTS: After exposure to DEX in vivo, inhibition of IL-6 and TNF-alpha decreased. Dexamethasone 27-30 interleukin 6 Homo sapiens 54-58 19274102-3 2009 Three compounds satisfied criteria of interaction analysis, competitively inhibited recombinant Stat3 binding to its immobilized pY-peptide ligand and inhibited IL-6-mediated tyrosine phosphorylation of Stat3. Tyrosine 175-183 interleukin 6 Homo sapiens 161-165 19164257-8 2009 The log value of the dialysate appearance rate of IL-6 had a strong positive correlation with D4/P creatinine (r2=0.1294, p<0.0001) and was significantly lower in the TA genotype than the TT genotype (201.7+/-14.42 vs 116.8+/-88.91 pg/minute, p=0.0358). Creatinine 99-109 interleukin 6 Homo sapiens 50-54 19365107-10 2009 Upon tumor necrosis factor-alpha stimulation, IL-6 and IL-8 mRNA and protein levels in A549-PLA2G2D-Ser cells were elevated compared with those of A549-PLA2G2D-Gly cells. Serine 100-103 interleukin 6 Homo sapiens 46-50 19365107-12 2009 CONCLUSIONS: PLA2G2D-Ser enhances the expression of IL-6 and IL-8 compared with PLA2G2D-Gly. Serine 21-24 interleukin 6 Homo sapiens 52-56 19251052-5 2009 In contrast to its role in liver, IL-6 is believed to be beneficial for insulin-regulated glucose metabolism in muscle. Glucose 90-97 interleukin 6 Homo sapiens 34-38 19247848-7 2009 In ATV-stimulated FLS a significant downregulation of proinflammatory cytokine (IL-6) and chemokine (IL-8) expression was detected (p<0.001). Atorvastatin 3-6 interleukin 6 Homo sapiens 80-84 18818415-2 2008 METHODS AND RESULTS: Monocyte and lymphocyte cytokine gene and protein expression of interleukin (IL)-6 were first shown to be greater in subjects with impaired glucose tolerance (IGT) than in subjects with normal glucose tolerance. Glucose 161-168 interleukin 6 Homo sapiens 85-103 18840498-5 2008 Non-stimulated, ethanol incubations up to 24h increased adiponectin release and mRNA expression (p<0.01) and decreased IL-6 release in both short-term [1.5h] (p<0.05) and long-term [24h] (p<0.01) incubations. Ethanol 16-23 interleukin 6 Homo sapiens 122-126 18840498-6 2008 Ethanol decreased LPS-stimulated IL-6, IL-8, TNF-alpha, and MCP-1 dose-dependently (all p<0.01). Ethanol 0-7 interleukin 6 Homo sapiens 33-37 19074889-7 2008 Treatment of myeloma cells with IL-6 induced serine phosphorylation of A1 and increased its binding to the myc IRES in vivo in myeloma cells. Serine 45-51 interleukin 6 Homo sapiens 32-36 18466654-6 2008 Consumption of pre-exercise high-carbohydrate meals (H-H and L-L) resulted in less perturbation of the circulating numbers of leucocytes, neutrophils and T lymphocyte subsets, and in decreased elevation of the plasma IL-6 concentrations immediately after exercise and during the 2 h recovery period compared with the H-L trial. Carbohydrates 33-45 interleukin 6 Homo sapiens 217-221 18775801-9 2008 An unexpected observation was the synergistic effect of BMPs and IL-6 on hepcidin-25 secretion, which points towards cross-talk between iron and inflammatory stimuli. Iron 136-140 interleukin 6 Homo sapiens 65-69 18775652-2 2008 Therefore, we investigated the influence of cortisol and dexamethasone on the in vitro production of TNF-alpha and IL-6 in blood cells of depressed inpatients at admission, in the course of MDD and in healthy controls. Hydrocortisone 44-52 interleukin 6 Homo sapiens 115-119 18775652-2 2008 Therefore, we investigated the influence of cortisol and dexamethasone on the in vitro production of TNF-alpha and IL-6 in blood cells of depressed inpatients at admission, in the course of MDD and in healthy controls. Dexamethasone 57-70 interleukin 6 Homo sapiens 115-119 18775652-7 2008 Under basal conditions, IL-6 levels were increased after treatment with both steroids. Steroids 77-85 interleukin 6 Homo sapiens 24-28 19114189-13 2008 Patients with anti-platelet factor 4/heparin levels of 0.45 OD units or greater 14 days after the operation had significantly higher interleukin 6 levels measured 1 hour after protamine administration. Heparin 37-44 interleukin 6 Homo sapiens 133-146 18982014-4 2008 DESIGN: The effect of acetylsalicylic acid (ASA), an inhibitor of COX, on IL-6 was assessed in human subjects and mice. Aspirin 22-42 interleukin 6 Homo sapiens 74-78 18982014-4 2008 DESIGN: The effect of acetylsalicylic acid (ASA), an inhibitor of COX, on IL-6 was assessed in human subjects and mice. Aspirin 44-47 interleukin 6 Homo sapiens 74-78 18982014-6 2008 METHODS AND RESULTS: In obese humans, low-dose ASA (150 mg day(-1) for 10 days) inhibited systemic IL-6 and reduced IL-6 release from SC WAT ex vivo (0.2 mM). Aspirin 47-50 interleukin 6 Homo sapiens 99-103 18982014-6 2008 METHODS AND RESULTS: In obese humans, low-dose ASA (150 mg day(-1) for 10 days) inhibited systemic IL-6 and reduced IL-6 release from SC WAT ex vivo (0.2 mM). Aspirin 47-50 interleukin 6 Homo sapiens 116-120 19022976-7 2008 Arg(high)/Gln(high) decreased the production of TNFalpha, IL-1beta, IL-8, and IL-6 (each P < 0.01). Arginine 0-3 interleukin 6 Homo sapiens 78-82 19022976-8 2008 Arg(low)/Gln(high) decreased IL-6 and IL-8 production (both P < 0.01), whereas Arg(high)/Gln(low) did not affect cytokine and NO production. Arginine 0-3 interleukin 6 Homo sapiens 29-33 18368033-5 2008 The results show that glucocorticoids (dexamethasone, prednisolone, cortisol and corticosterone) caused a concentration-dependent inhibition of LPS-stimulated IL-6 levels. Dexamethasone 39-52 interleukin 6 Homo sapiens 159-163 19114373-0 2008 [Effect of progesterone on high mobility group Box-1 protein-induced interleukin-6 release by human umbilic vein endothelial cells]. Progesterone 11-23 interleukin 6 Homo sapiens 69-82 19114373-5 2008 RESULTS: The IL-6 levels in HUVEC culture medium was slightly decreased after treatment with low-concentration HMGB1 but increased obviously following treatment with high-concentration HMGB1, and these effects could be dose-dependently inhibited by progesterone. Progesterone 249-261 interleukin 6 Homo sapiens 13-17 19114373-7 2008 CONCLUSIONS: Progesterone can dose-dependently inhibit HMGB1-induced IL-6 release from HUVECs, suggesting the protective role of progesterone in endotoxemia. Progesterone 129-141 interleukin 6 Homo sapiens 69-73 19383353-5 2008 Upon treatment with curcumin, IL-6/sIL-6R-induced STAT3 and Erk phosphorylation was dramatically reduced in the co-cultured cells. Curcumin 20-28 interleukin 6 Homo sapiens 30-34 19383353-7 2008 In a combination treatment with curcumin and bortezomib, IL-6/sIL-6R-induced STAT3 and Erk phosphorylation was effectively inhibited. Curcumin 32-40 interleukin 6 Homo sapiens 57-61 18368033-5 2008 The results show that glucocorticoids (dexamethasone, prednisolone, cortisol and corticosterone) caused a concentration-dependent inhibition of LPS-stimulated IL-6 levels. Hydrocortisone 68-76 interleukin 6 Homo sapiens 159-163 19161105-4 2008 The severity of bacterial peritonitis in liver cirrhosis was significantly associated with enhanced serum IL-6 and cortisol levels, and a decrease in serum DHEA sulfate in relation to serum IL-6 concentrations. Dehydroepiandrosterone Sulfate 156-168 interleukin 6 Homo sapiens 190-194 18583119-0 2008 Novel leads from Heliotropium ovalifolium, 4,7,8-trimethoxy-naphthalene-2-carboxylic acid and 6-hydroxy-5,7-dimethoxy-naphthalene-2-carbaldehyde show specific IL-6 inhibitory activity in THP-1 cells and primary human monocytes. 4,7,8-trimethoxy-naphthalene-2-carboxylic acid 43-89 interleukin 6 Homo sapiens 159-163 18583119-5 2008 Bioassay guided fractionation identified two compounds 4,7,8-trimethoxy-naphthalene-2-carboxylic acid and 6-hydroxy-5,7-dimethoxy-naphthalene-2-carbaldehyde with an IC(50) of 2.4 and 2.0 microM for IL-6 inhibition and an IC(50) of 15.6 and 7.0 microM for tumor necrosis factor-alpha (TNF-alpha) inhibition in THP-1 cells. 4,7,8-trimethoxy-naphthalene-2-carboxylic acid 55-101 interleukin 6 Homo sapiens 198-202 18975306-10 2008 ACh significantly reduced the production of IL-6, CXCL8, CCL2, CCL3, CCL5, and granulocyte colony-stimulating factor by IL-1-stimulated FLS. Acetylcholine 0-3 interleukin 6 Homo sapiens 44-48 18975306-13 2008 ACh did not reduce IL-6 transcription, but it decreased IL-6 mRNA half-life and reduced IL-6 mRNA steady-state levels. Acetylcholine 0-3 interleukin 6 Homo sapiens 56-60 18975306-13 2008 ACh did not reduce IL-6 transcription, but it decreased IL-6 mRNA half-life and reduced IL-6 mRNA steady-state levels. Acetylcholine 0-3 interleukin 6 Homo sapiens 56-60 18990769-6 2008 Polymorphisms in TNF and IL-6 were significantly associated with pain severity (for TNF GG, 4.12; GA, 5.38; AA, 5.50; P = 0.04) and with morphine equivalent daily dose (IL-6 GG, 69.61; GC, 73.17; CC, 181.67; P = 0.004), respectively. Morphine 137-145 interleukin 6 Homo sapiens 25-29 18617614-5 2008 Insulin decreased cyclic AMP (cAMP) but increased cyclic GMP (cGMP) levels, and IL-6 expression/release was stimulated by a cGMP analog. Cyclic GMP 124-128 interleukin 6 Homo sapiens 80-84 18617614-11 2008 Insulin-induced IL-6 gene expression is mediated by cGMP/cyclic GMP-dependent protein kinase/cAMP response element binding protein, whereas MAPK is involved in the insulin-stimulated IL-6 synthesis/release. Cyclic GMP 52-56 interleukin 6 Homo sapiens 16-20 18617614-11 2008 Insulin-induced IL-6 gene expression is mediated by cGMP/cyclic GMP-dependent protein kinase/cAMP response element binding protein, whereas MAPK is involved in the insulin-stimulated IL-6 synthesis/release. Cyclic AMP 93-97 interleukin 6 Homo sapiens 16-20 19060235-11 2008 A significant inverse correlation between DeltaSR and the increase in both IL-6 and ROS was observed. Reactive Oxygen Species 84-87 interleukin 6 Homo sapiens 75-79 18954528-4 2008 The deregulation of 17AAG and phorbol 12-myristate 13-acetate (PMA) on the IL-6 gene was determined by ELISA and transient gene expression assays using an IL-6 reporter vector. Tetradecanoylphorbol Acetate 30-61 interleukin 6 Homo sapiens 75-79 18954528-4 2008 The deregulation of 17AAG and phorbol 12-myristate 13-acetate (PMA) on the IL-6 gene was determined by ELISA and transient gene expression assays using an IL-6 reporter vector. Tetradecanoylphorbol Acetate 63-66 interleukin 6 Homo sapiens 75-79 18954528-4 2008 The deregulation of 17AAG and phorbol 12-myristate 13-acetate (PMA) on the IL-6 gene was determined by ELISA and transient gene expression assays using an IL-6 reporter vector. Tetradecanoylphorbol Acetate 63-66 interleukin 6 Homo sapiens 155-159 19034873-9 2008 LY294002, NH4Cl, CAPE, PD098059 and SB202190 all reduced albumin-mediated IL-6 release, but neither PDTC nor MG132 had any effect. Ammonium Chloride 10-15 interleukin 6 Homo sapiens 74-78 18697197-4 2008 Treatment of tumor cells with doxorubicin and cisplatin resulted in a substantial increase in the production of IL-6, CXCL8, CCL2, CCL5, BFGF, G-CSF and VEGF. Cisplatin 46-55 interleukin 6 Homo sapiens 112-116 18697197-4 2008 Treatment of tumor cells with doxorubicin and cisplatin resulted in a substantial increase in the production of IL-6, CXCL8, CCL2, CCL5, BFGF, G-CSF and VEGF. Doxorubicin 30-41 interleukin 6 Homo sapiens 112-116 19034873-9 2008 LY294002, NH4Cl, CAPE, PD098059 and SB202190 all reduced albumin-mediated IL-6 release, but neither PDTC nor MG132 had any effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 23-31 interleukin 6 Homo sapiens 74-78 18983746-0 2008 TNF-alpha and IL-6 affect human sperm function by elevating nitric oxide production. Nitric Oxide 60-72 interleukin 6 Homo sapiens 14-18 18418640-0 2008 Interactions of interleukin-6 gene polymorphisms with calcium intake and physical activity on bone mass in pre-menarche Chinese girls. Calcium 54-61 interleukin 6 Homo sapiens 16-29 18418640-16 2008 CONCLUSION: The IL-6 -634C/G polymorphism was significantly associated with BMD and the association might be modified by calcium intake or physical activity in pre-menarche Chinese girls. Calcium 121-128 interleukin 6 Homo sapiens 16-20 19010201-0 2008 Analysis of interleukin-6 and interleukin-8 in lung transplantation: correlation with nitric oxide administration. Nitric Oxide 86-98 interleukin 6 Homo sapiens 12-25 18727697-7 2008 The transplant induced upregulation in the inflammatory mediators CCL2, IL-1 beta, IL-6 and TNF-alpha were mitigated by hydrogen. Hydrogen 120-128 interleukin 6 Homo sapiens 83-87 18783834-8 2008 This study indicates an association between increased levels of plasma 8-iso-PGF2alpha and IL-6 with depressive symptomatology in elderly individuals and indicates the necessity for further investigation, possibly within the framework of an integrated involvement of oxidative damage and inflammation in the pathophysiology of depression in the elderly. 8-epi-prostaglandin F2alpha 71-86 interleukin 6 Homo sapiens 91-95 18958421-9 2008 Myricetin attenuated TNF-alpha and IL-6 but not IL-1beta and IL-8. myricetin 0-9 interleukin 6 Homo sapiens 35-39 19008611-12 2008 The GG genotype of IL-6 -G174C, TT genotype of IL-4 -C590T, and AA genotype of TNF-alpha -G308A cytokine gene polymorphisms may be causative factors for nonresponsiveness towards steroid therapy among INS children. Steroids 179-186 interleukin 6 Homo sapiens 19-23 18644822-9 2008 Steroids reduced inflammatory mediators (IL-6, IL-8 and CRP) and neutrophil activation whilst maintaining neutrophil phagocytic functions. Steroids 0-8 interleukin 6 Homo sapiens 41-45 18803936-6 2008 The 30-minute decrease in plasma IL-6 was correlated significantly and inversely with the concomitant increase in plasma insulin (r = -0.410, P = .02) and with the ratio of insulin to glucose at 30 minutes during the OGTT (r = -0.366, P = .04). Glucose 184-191 interleukin 6 Homo sapiens 33-37 18803936-7 2008 These data suggest that plasma concentrations of IL-6 are acutely decreased possibly because of the predominance of the anti-inflammatory effect of hyperinsulinemia over the proinflammatory effect of hyperglycemia after ingestion of a large quantity of glucose in obese individuals. Glucose 253-260 interleukin 6 Homo sapiens 49-53 19967068-2 2008 In the present study, we found that specific tyrphostin inhibitors of ErbB2 (AG825 and AG879), but not ErbB1 inhibitor (AG1478), suppressed IL-6-induced tyrosine phosphorylation of STAT3 in schwannoma cells. Tyrosine 153-161 interleukin 6 Homo sapiens 140-144 18719648-7 2008 To study GC-sensitivity in vitro, we performed dose-response studies of DEX-induced suppression of interleukin-6 (IL-6) secretion in skin fibroblast cultures. Dexamethasone 72-75 interleukin 6 Homo sapiens 99-112 18719648-7 2008 To study GC-sensitivity in vitro, we performed dose-response studies of DEX-induced suppression of interleukin-6 (IL-6) secretion in skin fibroblast cultures. Dexamethasone 72-75 interleukin 6 Homo sapiens 114-118 18562168-8 2008 CONCLUSION: These findings lend support to the hypothesis that a high-fiber diet is associated with lower plasma levels of IL-6 and TNF-alpha-R2. Dietary Fiber 70-75 interleukin 6 Homo sapiens 123-127 18616672-15 2008 CONCLUSION: While acute alcohol treatment alone activates STAT1/3 signaling pathways and induces SOCS3 and SOCS1 levels in monocytes, alcohol also leads to down-regulation of IL-6-, IFNalpha-, and IFNgamma-induced signaling via STAT1/STAT3 pathways, likely through excessive SOCS activation. Alcohols 24-31 interleukin 6 Homo sapiens 175-205 18828896-9 2008 beta-estradiol levels were significantly higher in women having fertility disorders as compared to fertile women and have significant correlations (r = 0.65; P < 0.05) with pDCs numbers, CD80 expression, IL-6 levels and IFN-gamma levels in these women. Estradiol 0-14 interleukin 6 Homo sapiens 207-211 18396374-6 2008 The second experiment examined whether anti-hyperalgesic effects of the COX-inhibitor ibuprofen were associated with decreased tissue levels of the pro-inflammatory cytokines IL-1 beta and IL-6. Ibuprofen 86-95 interleukin 6 Homo sapiens 189-193 18514163-5 2008 RESULTS: Peripheral levels of IL-6 covaried inversely with hippocampal grey matter volume, and this relationship persisted after accounting for several possible confounders, including age, gender, race, years of education, percent body fat, blood pressure, smoking, physical activity, hours of sleep, alcohol use, and total grey matter volume. Alcohols 301-308 interleukin 6 Homo sapiens 30-34 18593565-2 2008 CD95L-induced caspase activation leads to degradation of gp130, thereby suppressing IL-6-induced phosphorylation of STAT3 (Tyr(705)) and of tyrosine phosphatase SHP2 (Tyr(580)). Tyrosine 123-126 interleukin 6 Homo sapiens 84-88 18593565-2 2008 CD95L-induced caspase activation leads to degradation of gp130, thereby suppressing IL-6-induced phosphorylation of STAT3 (Tyr(705)) and of tyrosine phosphatase SHP2 (Tyr(580)). Tyrosine 167-170 interleukin 6 Homo sapiens 84-88 18616672-5 2008 Here we aimed to explore the effect of acute alcohol on induction of SOCS1/SOCS3 and regulation of STAT3/STAT1 pathways induced by IL-6 or IFNs in human monocytes. Alcohols 45-52 interleukin 6 Homo sapiens 131-135 18616672-12 2008 Indeed, we observed significant down-regulation of IL-6-, IFNalpha- and IFNgamma-induced STAT1 DNA binding as well as inhibition of IL-6- and IFNgamma-induced STAT3 when alcohol was added to monocytes 3 hours prior to the cytokine stimulation. Alcohols 170-177 interleukin 6 Homo sapiens 132-164 18616672-13 2008 Consistent with inhibition of IL-6-induced STAT3 DNA binding in alcohol-pretreated cells, the levels of IL-6-dependent genes, MCP-1 and ICAM-1, was reduced after IL-6 stimulation. Alcohols 64-71 interleukin 6 Homo sapiens 30-34 18616672-13 2008 Consistent with inhibition of IL-6-induced STAT3 DNA binding in alcohol-pretreated cells, the levels of IL-6-dependent genes, MCP-1 and ICAM-1, was reduced after IL-6 stimulation. Alcohols 64-71 interleukin 6 Homo sapiens 104-108 18616672-13 2008 Consistent with inhibition of IL-6-induced STAT3 DNA binding in alcohol-pretreated cells, the levels of IL-6-dependent genes, MCP-1 and ICAM-1, was reduced after IL-6 stimulation. Alcohols 64-71 interleukin 6 Homo sapiens 104-108 18616672-15 2008 CONCLUSION: While acute alcohol treatment alone activates STAT1/3 signaling pathways and induces SOCS3 and SOCS1 levels in monocytes, alcohol also leads to down-regulation of IL-6-, IFNalpha-, and IFNgamma-induced signaling via STAT1/STAT3 pathways, likely through excessive SOCS activation. Alcohols 134-141 interleukin 6 Homo sapiens 175-205 18544087-9 2008 We further examined the effect of CTD on the IL-6 signaling pathway in myeloma cells, and found that CTD inhibited phosphorylation of STAT3 at tyrosine 705 residue as early as 1 h after treatment and down-regulated the expression of the antiapoptotic bcl-xL protein. Tyrosine 143-151 interleukin 6 Homo sapiens 45-49 18690088-0 2008 Blockage of interleukin-6 signaling with 6-amino-4-quinazoline synergistically induces the inhibitory effect of bortezomib in human U266 cells. 6-amino-4-quinazoline 41-62 interleukin 6 Homo sapiens 12-25 18690088-4 2008 When U266 cells were treated with 6-amino-4-quinazoline, an NF-kappaB activation inhibitor, we determined that it most effectively blocked the interleukin (IL)-6-induced activation of MAPK and JAK/STAT pathways among different signaling inhibitors. 6-amino-4-quinazoline 34-55 interleukin 6 Homo sapiens 143-161 18690088-6 2008 In addition, 6-amino-4-quinazoline suppressed the production of IL-6, which affected MM cell proliferation. 6-amino-4-quinazoline 13-34 interleukin 6 Homo sapiens 64-68 18690088-7 2008 Furthermore, combined treatment with bortezomib and 6-amino-4-quinazoline effectively inhibited the IL-6 and soluble IL-6R-induced activation of STAT3 and extracellular signal-regulated kinase phosphorylation. 6-amino-4-quinazoline 52-73 interleukin 6 Homo sapiens 100-104 18815150-10 2008 Melatonin"s oncostatic actions include the direct augmentation of natural killer (NK) cell activity, which increases immunosurveillance, as well as the stimulation of cytokine production, for example, of interleukin (IL)-2, IL-6, IL-12, and interferon (IFN)-gamma. Melatonin 0-9 interleukin 6 Homo sapiens 224-228 18632923-0 2008 Lipoteichoic acid synergizes with glycosphingolipids to potently stimulate secretion of interleukin-6 from human blood cells. Glycosphingolipids 34-52 interleukin 6 Homo sapiens 88-101 18617548-9 2008 TCDD up-regulated the expression of IL-1beta, IL-6 and IL-8 through binding to AhR, and this effect was transmitted via the NF-kappaB and ERK signalling cascades. Polychlorinated Dibenzodioxins 0-4 interleukin 6 Homo sapiens 46-50 18774390-10 2008 Prolonged exposure to LPS induced functional steroid resistance to dexamethasone in normal human monocytes, as demonstrated by persistently increased IL-6 levels in the presence of dexamethasone. Steroids 45-52 interleukin 6 Homo sapiens 150-154 18841306-13 2008 In an assay to determine inhibition of the H2O2-activated release of PGE2, IL-6, and IL-8 in human normal fibroblast cell lines, the release of PGE2 and IL-6 was almost completely inhibited above concentrations of 0.05% and 1%, respectively. Hydrogen Peroxide 43-47 interleukin 6 Homo sapiens 75-79 18841306-13 2008 In an assay to determine inhibition of the H2O2-activated release of PGE2, IL-6, and IL-8 in human normal fibroblast cell lines, the release of PGE2 and IL-6 was almost completely inhibited above concentrations of 0.05% and 1%, respectively. Hydrogen Peroxide 43-47 interleukin 6 Homo sapiens 153-157 18841306-13 2008 In an assay to determine inhibition of the H2O2-activated release of PGE2, IL-6, and IL-8 in human normal fibroblast cell lines, the release of PGE2 and IL-6 was almost completely inhibited above concentrations of 0.05% and 1%, respectively. Dinoprostone 69-73 interleukin 6 Homo sapiens 153-157 18841306-13 2008 In an assay to determine inhibition of the H2O2-activated release of PGE2, IL-6, and IL-8 in human normal fibroblast cell lines, the release of PGE2 and IL-6 was almost completely inhibited above concentrations of 0.05% and 1%, respectively. Dinoprostone 144-148 interleukin 6 Homo sapiens 75-79 18551321-2 2008 We investigated the role of dexamethasone combined with antibiotics in diminishing urinary interleukin-6 (UIL-6) and UIL-8 concentrations during the acute phase of pyelonephritis compared with standard antibiotic therapy. Dexamethasone 28-41 interleukin 6 Homo sapiens 91-104 18707846-11 2008 The levels of TNF-alpha, IL-6, F1+2 and D-dimer significantly decreased 1h after infliximab infusion (P=0.005). Hydrogen 72-74 interleukin 6 Homo sapiens 25-29 18619543-7 2008 At 10(-6)M concentration, the steroids inhibited the phosphorylation of gp130 and diminished the IL-6-induced STAT3 phosphorylation and translocation to the nucleus. Steroids 30-38 interleukin 6 Homo sapiens 97-101 18790761-6 2008 FuEP2/Ex2 neutralized PGE2-induced cyclic AMP production, cyclic AMP-responsive element binding protein phosphorylation, and subsequent induction of cyclooxygenase-2, interleukin (IL)-1beta, and IL-6 mRNAs. Dinoprostone 22-26 interleukin 6 Homo sapiens 195-199 19186329-7 2008 These findings suggest that the postprandial response of plasma IL-6 concentrations may be influenced by the type of carbohydrate in the meal, central adiposity, and circulating cortisol concentrations in women. Carbohydrates 117-129 interleukin 6 Homo sapiens 64-68 18481110-5 2008 Acute exposure of HPMC to conventional low-glucose-based PD solution resulted in a time-dependent increase in heat-shock protein (HSP-72) expression, impaired viability, and reduced ability to release IL-6 in response to stimulation. hydroxypropylmethylcellulose-lactose matrix 18-22 interleukin 6 Homo sapiens 201-205 18481110-5 2008 Acute exposure of HPMC to conventional low-glucose-based PD solution resulted in a time-dependent increase in heat-shock protein (HSP-72) expression, impaired viability, and reduced ability to release IL-6 in response to stimulation. Glucose 43-50 interleukin 6 Homo sapiens 201-205 18314542-9 2008 Moreover, TNF-alpha acts via a p38 MAPK-dependent pathway to stabilize the IL-6 mRNA transcript (TNF-alpha, t(1/2) = 9.6 h; SB203580 + TNF-alpha, t(1/2) = 1.5 h), exogenous expression of MKP-1 significantly inhibits TNF-alpha-induced IL-6 secretion and MKP-1 siRNA reverses the inhibition of TNF-alpha-induced IL-6 secretion by dexamethasone. Dexamethasone 328-341 interleukin 6 Homo sapiens 75-79 18684916-0 2008 Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression. Tretinoin 0-13 interleukin 6 Homo sapiens 149-153 18314542-6 2008 TNF-alpha-induced IL-6 mRNA decays at a significantly faster rate in ASM cells pretreated with the corticosteroid dexamethasone (t(1/2) = 2.4 h), compared to vehicle (t(1/2) = 9.0 h; P < 0.05) (results are expressed as decay constants [k] [mean +/- SEM] and half-life [h]). Dexamethasone 114-127 interleukin 6 Homo sapiens 18-22 18553108-0 2008 Interleukin-6 counteracts effects of cyclosporin A on extracellular matrix metabolism by human dermal fibroblasts. Cyclosporine 37-50 interleukin 6 Homo sapiens 0-13 18503751-5 2008 Importantly, small-interfering RNA-mediated reduction of endogenous Y14 expression decreased IL-6-induced tyrosine-phosphorylation, nuclear accumulation, and DNA-binding activity of STAT3, as well as IL-6/STAT3-dependent gene expression. Tyrosine 106-114 interleukin 6 Homo sapiens 93-97 18034847-8 2008 Aspirin reduced IL-6 with 0.7 +/- 0.5 pg/ml, whereas use of placebo resulted in a mean increase of 0.2 +/- 0.8 pg/ml (P = 0.302). Aspirin 0-7 interleukin 6 Homo sapiens 16-20 18541328-8 2008 Plasma IL-6 (-25%), CRP (-55%) and GGT (-25%) concentrations declined significantly in the rosiglitazone group. Rosiglitazone 91-104 interleukin 6 Homo sapiens 7-11 18636164-0 2008 Stress-associated hormone, norepinephrine, increases proliferation and IL-6 levels of human pancreatic duct epithelial cells and can be inhibited by the dietary agent, sulforaphane. Norepinephrine 27-41 interleukin 6 Homo sapiens 71-75 18446686-4 2008 The subjects with abnormal glucose challenge test results had higher IL-6 levels (0.9 [0.7-1.3] pg/ml, p=0.005) and similar levels of other cytokines as compared with the women with normal glucose tolerance. Glucose 27-34 interleukin 6 Homo sapiens 69-73 18636164-6 2008 We also evaluated the ability of norepinephrine to induce interleukin-6 (IL-6), interleukin-10 (IL-10), and vascular endothelial growth factor (VEGF). Norepinephrine 33-47 interleukin 6 Homo sapiens 58-71 18636164-6 2008 We also evaluated the ability of norepinephrine to induce interleukin-6 (IL-6), interleukin-10 (IL-10), and vascular endothelial growth factor (VEGF). Norepinephrine 33-47 interleukin 6 Homo sapiens 73-77 18636164-8 2008 We found that norepinephrine can increase the IL-6 and VEGF but not IL-10 levels secreted by human pancreatic duct epithelial cells. Norepinephrine 14-28 interleukin 6 Homo sapiens 46-50 18636164-11 2008 Furthermore, sulforaphane also inhibits norepinephrine-mediated increase of the IL-6 levels but not VEGF levels. Norepinephrine 40-54 interleukin 6 Homo sapiens 80-84 18636164-12 2008 Our study is the first to demonstrate that stress-associated hormone, norepinephrine, can increase the cell proliferation and IL-6 levels of human pancreatic duct epithelial cells, which can be inhibited by sulforaphane, a chemopreventive agent and a natural compound from the Cruciferous vegetables. Norepinephrine 70-84 interleukin 6 Homo sapiens 126-130 18649055-0 2008 Atorvastatin induces associated reductions in platelet P-selectin, oxidized low-density lipoprotein, and interleukin-6 in patients with coronary artery diseases. Atorvastatin 0-12 interleukin 6 Homo sapiens 105-118 18660424-9 2008 Poly(I:C)-induced expression of IL-6, IL-8, G-CSF, MIP-1beta, exotaxin, RANTES, and ICAM-1 was inhibited differentially by the MAPK inhibitors PD98059 and SB203580 and by JNK inhibitor II. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 143-150 interleukin 6 Homo sapiens 32-36 18420533-0 2008 The effect of IL6-174C/G polymorphism on postprandial triglyceride metabolism in the GOLDN studyboxs. Triglycerides 54-66 interleukin 6 Homo sapiens 14-17 18420533-9 2008 These results suggest that the functional polymorphism -174C>G at the IL6 locus determines the difference in both fasting and postprandial TG metabolism. Triglycerides 142-144 interleukin 6 Homo sapiens 73-76 18545980-8 2008 Synoviocytes spontaneously released low quantities of IL-6; the incubation with BzATP induced the release of larger amounts of the cytokine, and such a release was blunted by the P2X7 antagonist oxidized ATP. Adenosine Triphosphate 82-85 interleukin 6 Homo sapiens 54-58 18547706-7 2008 The metal allergens nickel and cobalt could be detected by measuring Interleukin-6 and macrophage inflammatory protein 1-beta (MIP-1beta, CCL-4) in coculture supernatants. Metals 4-9 interleukin 6 Homo sapiens 69-82 18580215-10 2008 Significant increases in systemic IL-6 and IL-8 values were measured only in patients undergoing DAP and SP. TFF2 protein, human 105-107 interleukin 6 Homo sapiens 34-38 19026125-1 2008 OBJECTIVE: To assess the association of polymorphisms of the IL-6 receptor gene (+24013A/G:Ala31Ala; +48892 A/C:Asp358Ala), the IL-8 receptor gene (+2607G/C:Ser/Thr IL-8RA), and TNF-alpha 238 (G/A) single nucleotide polymorphism (SNP) with Behcet"s disease in patients of German or Turkish origin. Serine 157-160 interleukin 6 Homo sapiens 61-65 19026125-1 2008 OBJECTIVE: To assess the association of polymorphisms of the IL-6 receptor gene (+24013A/G:Ala31Ala; +48892 A/C:Asp358Ala), the IL-8 receptor gene (+2607G/C:Ser/Thr IL-8RA), and TNF-alpha 238 (G/A) single nucleotide polymorphism (SNP) with Behcet"s disease in patients of German or Turkish origin. Threonine 161-164 interleukin 6 Homo sapiens 61-65 17987062-5 2008 IL-6-induced amplification of A1 receptor function enhances the responses to readily released adenosine during hypoxia, enables neuronal rescue from glutamate-induced death, and protects animals from chemically induced convulsing seizures. Adenosine 94-103 interleukin 6 Homo sapiens 0-4 17987062-5 2008 IL-6-induced amplification of A1 receptor function enhances the responses to readily released adenosine during hypoxia, enables neuronal rescue from glutamate-induced death, and protects animals from chemically induced convulsing seizures. Glutamic Acid 149-158 interleukin 6 Homo sapiens 0-4 18649055-11 2008 The reduction (%) in IL-6 between 4 and 12 weeks after atorvastatin administration significantly correlated with that of MDALDL and of platelet P-selectin (r = 0.65, P < 0.05 and r = 0.70, P < 0.05, respectively). Atorvastatin 55-67 interleukin 6 Homo sapiens 21-25 18468809-5 2008 GR sensitivity to dexamethasone was evaluated through IL-6 inhibition in stimulated whole blood. Dexamethasone 18-31 interleukin 6 Homo sapiens 54-58 18430776-5 2008 RESULTS: The IL-6 concentration after 30-min infusion was approximately 4 (saline) and 140 pg/ml (rhIL-6). Sodium Chloride 75-81 interleukin 6 Homo sapiens 13-17 18601853-0 2008 [Effects of curcumin on secretion of adiponectin and interleukin-6 in human adipose tissues: an in vitro study]. Curcumin 12-20 interleukin 6 Homo sapiens 53-66 18309490-9 2008 IL-6 levels showed positive correlation with CRP, and negative correlation with Hb, RBC counts and serum iron, but TNFalpha did not show any correlation. Iron 105-109 interleukin 6 Homo sapiens 0-4 18601853-6 2008 CONCLUSION: 100 microg/ml curcumin can increase APN secretion and decrease IL-6 secretion in human adipose tissues cultivated in vitro. Curcumin 26-34 interleukin 6 Homo sapiens 75-79 19016005-3 2008 In this study, we demonstrated that IL-6 increased lipolysis in differentiated porcine adipocytes by activation of extracellular signal-related kinase (ERK), which was inhibited by specific ERK inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 204-211 interleukin 6 Homo sapiens 36-40 18549505-13 2008 Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression (IC50 = 2 muM) and a reduction of secreted IL-6 and PGE2 (IC50 ~ 20 muM). Curcumin 0-8 interleukin 6 Homo sapiens 118-122 18549505-13 2008 Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression (IC50 = 2 muM) and a reduction of secreted IL-6 and PGE2 (IC50 ~ 20 muM). Curcumin 0-8 interleukin 6 Homo sapiens 193-197 18549505-13 2008 Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression (IC50 = 2 muM) and a reduction of secreted IL-6 and PGE2 (IC50 ~ 20 muM). Resveratrol 13-24 interleukin 6 Homo sapiens 118-122 18549505-13 2008 Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression (IC50 = 2 muM) and a reduction of secreted IL-6 and PGE2 (IC50 ~ 20 muM). Resveratrol 13-24 interleukin 6 Homo sapiens 193-197 19034703-8 2008 This study demonstrates that berberine may inhibit the expression and production of TNF-alpha, MCP-1, and IL-6 in AcLDL-stimulated macrophages. Berberine 29-38 interleukin 6 Homo sapiens 106-110 18484740-10 2008 IL-6 but not IL-1beta determinations were lower in both saline and phosphate-buffered saline as compared to vaginal fluid matrix, with no significant effect of pH. Sodium Chloride 56-62 interleukin 6 Homo sapiens 0-4 19034703-0 2008 Berberine inhibits the expression of TNFalpha, MCP-1, and IL-6 in AcLDL-stimulated macrophages through PPARgamma pathway. Berberine 0-9 interleukin 6 Homo sapiens 58-62 19034703-6 2008 In this study, we investigated the effects and the mechanism of action of berberine on the expression and secretion of TNFalpha, MCP-1, and IL-6 in vitro to identify new pharmacological actions of berberine. Berberine 74-83 interleukin 6 Homo sapiens 140-144 19034703-7 2008 The results of RT-PCR and ELISA shows that berberine may inhibit the expression and secretion of the tumor necrosis factor alpha (TNFalpha), monocyte chemoattractant protein 1 (MCP-1), and interleukin-6 (IL-6) in macrophages stimulated by acetylated low-density lipoprotein (AcLDL), whereas the peroxisome proliferator-activated receptor gamma (PPARgamma) inhibitor GW9662 could attenuate this effect of berberine. Berberine 43-52 interleukin 6 Homo sapiens 189-202 19034703-7 2008 The results of RT-PCR and ELISA shows that berberine may inhibit the expression and secretion of the tumor necrosis factor alpha (TNFalpha), monocyte chemoattractant protein 1 (MCP-1), and interleukin-6 (IL-6) in macrophages stimulated by acetylated low-density lipoprotein (AcLDL), whereas the peroxisome proliferator-activated receptor gamma (PPARgamma) inhibitor GW9662 could attenuate this effect of berberine. Berberine 43-52 interleukin 6 Homo sapiens 204-208 18319729-7 2008 The stroke aspirin-resistant group had higher levels of IL-6 than the stroke aspirin-sensitive group (2.4+/-1 versus 1.8+/-0.9 ng/mL, P=0.037). Aspirin 11-18 interleukin 6 Homo sapiens 56-60 18319729-9 2008 These analyses showed that IL-6 was independently associated with stroke severity as the outcome (B=3.738, P=0.036), and aspirin resistance was independently associated with IL-6 (B=0.765, P=0.005) as the outcome. Aspirin 121-128 interleukin 6 Homo sapiens 174-178 18357586-4 2008 Further, Curcumin inhibited LPS-induced IL-1 and IL-6 secretion and blockage of HO-1 expression/activity by HO-1 siRNA or HO-1 inhibitor, SnPP reversed the inhibitory effects of Curcumin on cytokines secretion. Curcumin 9-17 interleukin 6 Homo sapiens 49-53 18598184-8 2008 Resveratrol at concentrations > or =50 micromol/mL significantly inhibited IL-8 and IL-6 production. Resveratrol 0-11 interleukin 6 Homo sapiens 87-91 18583261-5 2008 RESULTS: In group A, rosiglitazone treatment resulted in significantly reduced serum hs-CRP, IL-1beta, IL-6, TNF-alpha, FPG and insulin resistance index (P<0.01). Rosiglitazone 21-34 interleukin 6 Homo sapiens 103-107 18462799-5 2008 Treatment of HIF-1alpha knockdown cells with extracellular ATP in combination with LPS preserved the IL-6 expression but not the activity of ASK1 on the level observed in LPS-stimulated control cells. Adenosine Triphosphate 59-62 interleukin 6 Homo sapiens 101-105 18462799-6 2008 We therefore suggested that HIF-1alpha protein supports LPS-dependent expression of IL-6 by preventing depletion of ATP. Adenosine Triphosphate 116-119 interleukin 6 Homo sapiens 84-88 18457971-6 2008 Transfection of cPLA(2) antisense oligonucleotides or pre-treatment with cPLA(2) inhibitor AACOCF3 abolished IL-1beta and IL-6 release in a dose-dependent manner. Oligonucleotides 34-50 interleukin 6 Homo sapiens 122-126 18457971-9 2008 Treatment with the COX-2 inhibitor (NS-398) or COX-2 antisense oligonucleotides also diminished IL-1beta and IL-6 release. Oligonucleotides 63-79 interleukin 6 Homo sapiens 109-113 18348986-8 2008 By oligonucleotide precipitation assay, IL-6 rapidly promoted a complex containing both Sp1/3 and Stat1/3 on the Sp1/3 elements. Oligonucleotides 3-18 interleukin 6 Homo sapiens 40-44 18285417-10 2008 Finally, change in the PYR/Cr ratio was positively associated baseline IL-6, hs-CRP, and their changes (all P < 0.05) in women, but not men. Creatinine 27-29 interleukin 6 Homo sapiens 71-75 18480275-7 2008 Consistently, TNFalpha and IL-1beta enhanced AMPA- or NMDA-induced currents, and IL-1beta and IL-6 suppressed GABA- and glycine-induced currents. Glycine 120-127 interleukin 6 Homo sapiens 94-98 18480275-7 2008 Consistently, TNFalpha and IL-1beta enhanced AMPA- or NMDA-induced currents, and IL-1beta and IL-6 suppressed GABA- and glycine-induced currents. gamma-Aminobutyric Acid 110-114 interleukin 6 Homo sapiens 94-98 18267353-2 2008 IL-6 SNP at position -174 is associated with age-related diseases characterized by an impaired Zn status. Zinc 95-97 interleukin 6 Homo sapiens 0-4 18353383-6 2008 RESULTS: For untreated patients urine interleukin-6 and cyclic guanosine monophosphate were associated with urothelial epidermal growth factor receptor staining (for interleukin-6 r = 0.29; 95% CI 0.07, 0.51; p = 0.01 and for cyclic guanosine monophosphate r = 0.34; 95% CI 0.13, 0.55; p = 0.002). Cyclic GMP 56-86 interleukin 6 Homo sapiens 166-179 18319319-5 2008 Finally, when subjects were stratified on the basis of their respective concentrations of IL-6 and TNF-alpha (using the 50th percentile of their overall distribution), an ANOVA revealed an independent contribution of IL-6 to the variation of fasting insulin (P < 0.01) and each of these two cytokines to the variation of insulin levels measured after a 75-g oral glucose challenge (P <0.01 for IL-6 and P < 0.05 for TNF-alpha). Glucose 366-373 interleukin 6 Homo sapiens 217-221 18319319-5 2008 Finally, when subjects were stratified on the basis of their respective concentrations of IL-6 and TNF-alpha (using the 50th percentile of their overall distribution), an ANOVA revealed an independent contribution of IL-6 to the variation of fasting insulin (P < 0.01) and each of these two cytokines to the variation of insulin levels measured after a 75-g oral glucose challenge (P <0.01 for IL-6 and P < 0.05 for TNF-alpha). Glucose 366-373 interleukin 6 Homo sapiens 217-221 18528653-9 2008 Cartilage degeneration in OA may also be due, at least in part, to IL-6 and MMP-13 produced by SBOs. sbos 95-99 interleukin 6 Homo sapiens 67-71 18353383-6 2008 RESULTS: For untreated patients urine interleukin-6 and cyclic guanosine monophosphate were associated with urothelial epidermal growth factor receptor staining (for interleukin-6 r = 0.29; 95% CI 0.07, 0.51; p = 0.01 and for cyclic guanosine monophosphate r = 0.34; 95% CI 0.13, 0.55; p = 0.002). Cyclic GMP 226-256 interleukin 6 Homo sapiens 38-51 17611043-2 2008 In this study, the in vitro effects of a new aziridine, 2-hydroxy-methyl-1-(N-phtaloyltryptophyl) aziridine, were determined on the proliferative responses of human lymphocytes stimulated by mitogens and on interleukin (IL-2, IL-6) secretion. 2-hydroxy-methyl-1-(n-phtaloyltryptophyl) aziridine 56-107 interleukin 6 Homo sapiens 226-230 18343502-0 2008 Rapamycin suppresses TLR4-triggered IL-6 and PGE(2) production of colon cancer cells by inhibiting TLR4 expression and NF-kappaB activation. Sirolimus 0-9 interleukin 6 Homo sapiens 36-40 18343502-7 2008 Furthermore, disruption of NF-kappaB pathway contributes to the inhibition of TLR4-induced IL-6, PGE(2) production and invasion by rapamycin in colon cancer cells. Sirolimus 131-140 interleukin 6 Homo sapiens 91-95 18273635-13 2008 In particular, lactate up-regulates the expression of interleukin-6 (3 days, 4.11-fold), of heat shock protein 70 (3 days, 2.36-fold) and of hypoxia-inducible factor-1alpha (3 days, 2.09-fold). Lactic Acid 15-22 interleukin 6 Homo sapiens 54-67 18349186-0 2008 The mu opioid receptor mediates morphine-induced tumor necrosis factor and interleukin-6 inhibition in toll-like receptor 2-stimulated monocytes. Morphine 32-40 interleukin 6 Homo sapiens 75-88 18053592-9 2008 RESULTS: Patients treated with carvedilol had a significant improvement in functional class compared with the baseline values (P=0.001), with a decrease in the levels of cytokines (IL-6 [P=0.02] and TNF-alpha [P=0.02]). Carvedilol 31-41 interleukin 6 Homo sapiens 181-185 18053592-11 2008 CONCLUSIONS: Carvedilol treatment for 4 months resulted in a significant improvement of RVEF, which paralleled the improvement of LVEF and the decreasing of TNF-alpha and IL-6 levels in patients with systolic HF. Carvedilol 13-23 interleukin 6 Homo sapiens 171-175 17951041-0 2008 Berberine inhibits TPA-induced MMP-9 and IL-6 expression in normal human keratinocytes. Berberine 0-9 interleukin 6 Homo sapiens 41-45 17951041-4 2008 Our results demonstrated that berberine dose-dependently inhibited basal and TPA-induced expression and activity of MMP-9, and also suppressed TPA-induced IL-6 expression. Berberine 30-39 interleukin 6 Homo sapiens 155-159 18414237-10 2008 IL-6 production by the CaCO2 cell is also greatest when CaCO2 cells incubated with EtOH undergoes H/R. Ethanol 83-87 interleukin 6 Homo sapiens 0-4 18349186-8 2008 Mu opioid receptor activation specifically mediated this morphine-induced TNF and IL-6 inhibition in monocytes. Morphine 57-65 interleukin 6 Homo sapiens 82-86 18349186-12 2008 CONCLUSIONS: The mu opioid receptor mediates morphine-induced TNF and IL-6 inhibition in PGN-stimulated monocytes, but not in PBMCs. Morphine 45-53 interleukin 6 Homo sapiens 70-74 18282234-7 2008 We found that increased levels of IL-6 from autologous monocytes in co-culture with MF-spheroids predicted recurrence with a hazard ratio (HR) of 1.5 [confidence interval (CI): 1.01-2.60; P = 0.05] and co-culture with BF-spheroids and monocytes predicted recurrence (HR = 4.17; CI: 1.54-11.29; P = 0.005). bf-spheroids 218-230 interleukin 6 Homo sapiens 34-38 18305082-11 2008 IL-6, IL-10, and sICAM-1 were significantly lower in the HES group than in the gelatin group on the first and second PODs. Hydroxyethyl Starch Derivatives 57-60 interleukin 6 Homo sapiens 0-4 18374881-9 2008 Atorvastatin induced a significant decrease of matrix metalloproteinase-9 activity, high-sensitivity C-reactive protein, tumor necrosis factor-alpha, interleukin-6, and malondialdehyde, and a significant increase of endothelial superoxide dismutase activity when compared with placebo. Atorvastatin 0-12 interleukin 6 Homo sapiens 150-163 18664200-3 2008 The modulation of cetirizine on the production of interferon (IFN)-gamma, interleukin (IL)-1beta, IL-6 and IL-8 in HaCaT cells and fibroblasts was measured by ELISA. Cetirizine 18-28 interleukin 6 Homo sapiens 98-102 18387391-0 2008 Urinary epidermal growth factor and interleukin-6 levels in patients with painful bladder syndrome/interstitial cystitis treated with cyclosporine or pentosan polysulfate sodium. Cyclosporine 134-146 interleukin 6 Homo sapiens 36-49 18328837-7 2008 Increased norepinephrine responses were related to larger CRP and IL-6 increases to mental challenge tasks (p values <0.05). Norepinephrine 10-24 interleukin 6 Homo sapiens 66-70 18387391-7 2008 In the CyA group, post-treatment urinary EGF levels were significantly reduced (from 35 +/- 15.8 to 28.3 +/- 17.9 ng/mg creatinine; P <0.034), whereas the urinary IL-6 levels were not affected by CyA or PPS treatment in the whole group. Cyclosporine 7-10 interleukin 6 Homo sapiens 166-170 18387391-10 2008 Interleukin-6 levels did not change significantly in all treated patients after either CyA or PPS treatment, but in older patients the levels were reduced after CyA treatment. Cyclosporine 87-90 interleukin 6 Homo sapiens 0-13 18322229-0 2008 Adenosine promotes IL-6 release in airway epithelia. Adenosine 0-9 interleukin 6 Homo sapiens 19-23 18322229-5 2008 In the present work, we examined the role of adenosine in releasing IL-6 from airway epithelia. Adenosine 45-54 interleukin 6 Homo sapiens 68-72 18322229-6 2008 In Calu-3 human airway epithelial cells, apical but not basolateral adenosine elicited robust, apically polarized release of IL-6, along with proinflammatory IL-8. Adenosine 68-77 interleukin 6 Homo sapiens 125-129 18322229-7 2008 Both protein kinase A and protein kinase C mediated the adenosine-induced IL-6 release, at least partly via phosphorylation of CREB. Adenosine 56-65 interleukin 6 Homo sapiens 74-78 18330958-9 2008 ETV-treated group secreted significantly more IL-12 (157.60 +/- 26.85 pg/mL vs 132.60 +/- 22.00 pg/mL (P < 0.05) and had a lower level of IL-6 in the culture supernatant (83.05 +/- 13.88 pg/mL vs 93.60 +/- 13.61 pg/mL, P < 0.05) than CHB control group. entecavir 0-3 interleukin 6 Homo sapiens 141-145 18347184-6 2008 Parthenolide overcame the proliferative effects of cytokines interleukin-6 and insulin-like growth factor I, whereas the adhesion of MM cells to bone marrow stromal cells partially protected MM cells against parthenolide effect. parthenolide 0-12 interleukin 6 Homo sapiens 61-107 18347184-7 2008 In addition, parthenolide blocked interleukin-6 secretion from bone marrow stromal cells triggered by the adhesion of MM cells. parthenolide 13-25 interleukin 6 Homo sapiens 34-47 18356656-11 2008 A single dose of dexamethasone reduces IL-6 and PNE levels associated with CPB. Dexamethasone 17-30 interleukin 6 Homo sapiens 39-43 18195020-6 2008 Secondly, knockdown of C/EBPbeta and -delta isoforms abolished both SOCS-3 induction and inhibition of IL-6 signaling in response to cAMP. Cyclic AMP 133-137 interleukin 6 Homo sapiens 103-107 18177491-6 2008 RESULTS: CBMCs from newborns with allergic mothers tended to have a lower IL-6 response following an LPS (P=0.09) challenge compared with the group without maternal allergy while p38-MAPK activation levels did not differ between the groups. cbmcs 9-14 interleukin 6 Homo sapiens 74-78 17922475-9 2008 IL-6 production was stimulated by PMA in both C and T2D patients; this effect was prevented by rosiglitazone in a Sr202-inhibitable manner. Rosiglitazone 95-108 interleukin 6 Homo sapiens 0-4 18336663-7 2008 We are particularly interested in data showing that factors produced by Kupffer cells incubated with apoptotic bodies can lead to production of tumor necrosis factor-alpha and interleukin-6, and that this effect is exacerbated in the setting of alcohol administration. Alcohols 245-252 interleukin 6 Homo sapiens 176-189 18177344-5 2008 SAPK/JNK-specific inhibitor SP600125 slightly suppressed IL-6 production although no evident effects were obtained for TNF-alpha and IL-1beta; ERK1/2 inhibitor PD98059 blocked both TNF-alpha and IL-1beta, but not IL-6 production. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 160-167 interleukin 6 Homo sapiens 57-61 18177344-5 2008 SAPK/JNK-specific inhibitor SP600125 slightly suppressed IL-6 production although no evident effects were obtained for TNF-alpha and IL-1beta; ERK1/2 inhibitor PD98059 blocked both TNF-alpha and IL-1beta, but not IL-6 production. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 160-167 interleukin 6 Homo sapiens 213-217 18557135-7 2008 We here show that exposure to IL-1 and IL-6 significantly increased the levels of DCF-detectable ROS in cells cultured in physiologic concentrations of Mg, but not in Mg-deprived cells. Reactive Oxygen Species 97-100 interleukin 6 Homo sapiens 39-43 18214943-8 2008 Zn supplementation was marginally effective in reducing percentage increase in plasma IL-6 and IL-8 while increasing the percentage change in ex vivo generation of IL-2 in isolated mononuclear cell. Zinc 0-2 interleukin 6 Homo sapiens 86-90 18310376-10 2008 Cord blood IL-6 levels were in direct relationship with corrected adrenal volume (r=0.372, P=.019), fetal cortisol (r=0.428, P=.010), and DHEAS (r=0.521, P<.001). Hydrocortisone 106-114 interleukin 6 Homo sapiens 11-15 18066713-3 2008 When coincubating A549 with LPS and meta-iodobenzylguanidine or novobiocin, selective arginine-dependent ART-inhibitors, the release of IL-6 and IL-8 was inhibited in a concentration-dependent manner. Novobiocin 64-74 interleukin 6 Homo sapiens 136-140 18066713-3 2008 When coincubating A549 with LPS and meta-iodobenzylguanidine or novobiocin, selective arginine-dependent ART-inhibitors, the release of IL-6 and IL-8 was inhibited in a concentration-dependent manner. Arginine 86-94 interleukin 6 Homo sapiens 136-140 18326322-4 2008 However, recent analyses have clearly shown that hepcidin, of which expression is induced by inflammatory cytokines such as IL-1beta and IL-6, suppresses the expression of the iron transporter, ferroportin-1, thereby inhibiting the absorption of iron from the duodenum, the release of iron from the reticulo-endothelial system. Iron 176-180 interleukin 6 Homo sapiens 137-141 18326322-4 2008 However, recent analyses have clearly shown that hepcidin, of which expression is induced by inflammatory cytokines such as IL-1beta and IL-6, suppresses the expression of the iron transporter, ferroportin-1, thereby inhibiting the absorption of iron from the duodenum, the release of iron from the reticulo-endothelial system. Iron 246-250 interleukin 6 Homo sapiens 137-141 18160129-0 2008 Effects of estradiol on regulation of corticotropin-releasing factor gene and interleukin-6 production via estrogen receptor type beta in hypothalamic 4B cells. Estradiol 11-20 interleukin 6 Homo sapiens 78-91 17664049-4 2008 The CSF2 IL-6 levels of patients with/without dexamethasone were significantly lower than for CSF1 IL-6 levels (p = 0.0077, and p = 0.0431, respectively). Dexamethasone 46-59 interleukin 6 Homo sapiens 9-13 18234497-4 2008 In the present study, a series of curcumin analogues with more stable chemical structures were synthesized and several compounds showed an enhanced ability to inhibit lipopolysaccharide (LPS)-induced TNF-alpha and IL-6 synthesis in macrophages. Curcumin 34-42 interleukin 6 Homo sapiens 214-218 18327406-8 2008 Under serum-free conditions, heparin demonstrated dose-dependent anti-inflammatory effects, significantly reducing secretion of pro-inflammatory cytokines (IL-1beta, IL-6, IL-8, and TNF-alpha) in response to LPS-stimulation of THP-1 cells and primary monocytes. Heparin 29-36 interleukin 6 Homo sapiens 166-170 17852075-3 2008 An enzyme-linked immunosorbent assay from R&D was used for determination of serum and plasma IL-6. Adenosine Monophosphate 44-47 interleukin 6 Homo sapiens 97-101 17881186-0 2008 Aspirin, but not propranolol, attenuates the acute stress-induced increase in circulating levels of interleukin-6: a randomized, double-blind, placebo-controlled study. Aspirin 0-7 interleukin 6 Homo sapiens 100-113 17881186-2 2008 We investigated the effect of aspirin and propranolol on the responsiveness of plasma IL-6 levels to acute psychosocial stress. Aspirin 30-37 interleukin 6 Homo sapiens 86-90 17881186-6 2008 The change in IL-6 from pre-stress to 105 min post-stress differed between subjects with aspirin medication and those without (p =0.033; eta p2=0.059). Aspirin 89-96 interleukin 6 Homo sapiens 14-18 17932106-4 2008 In contrast, ER displaced p65 and associated coregulators from the IL-6 promoter, demonstrating a gene-specific role for CBP in integrating inflammatory and steroid signaling. Steroids 157-164 interleukin 6 Homo sapiens 67-71 17881186-7 2008 IL-6 levels increased less from pre-stress to 105 min post-stress (p <0.027) and were lower (p =0.010) at 105 min post-stress in subjects with aspirin than in subjects without aspirin. Aspirin 146-153 interleukin 6 Homo sapiens 0-4 17881186-7 2008 IL-6 levels increased less from pre-stress to 105 min post-stress (p <0.027) and were lower (p =0.010) at 105 min post-stress in subjects with aspirin than in subjects without aspirin. Aspirin 179-186 interleukin 6 Homo sapiens 0-4 17881186-11 2008 Aspirin but not propranolol attenuated the stress-induced increase in plasma IL-6 levels. Aspirin 0-7 interleukin 6 Homo sapiens 77-81 18181043-11 2008 Intracellular IL-6, as well as IL-6 in the conditioned medium, decreased in OUR-10 cells following treatment with increasing amounts of DEX. Dexamethasone 136-139 interleukin 6 Homo sapiens 14-18 18181043-11 2008 Intracellular IL-6, as well as IL-6 in the conditioned medium, decreased in OUR-10 cells following treatment with increasing amounts of DEX. Dexamethasone 136-139 interleukin 6 Homo sapiens 31-35 18181043-13 2008 CONCLUSION: DEX treatment is a candidate for advanced RCC therapy by inhibiting the activation of NF-kappa B and its downstream products such as IL-6, IL-8 and VEGF. Dexamethasone 12-15 interleukin 6 Homo sapiens 145-149 18222974-9 2008 In addition, MEVA attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated secretion of tumor necrosis factor-alpha, interleukin-6 (IL-6), and IL-8 in human mast cells. ANAVACYM protocol 13-17 interleukin 6 Homo sapiens 155-168 18222974-9 2008 In addition, MEVA attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated secretion of tumor necrosis factor-alpha, interleukin-6 (IL-6), and IL-8 in human mast cells. ANAVACYM protocol 13-17 interleukin 6 Homo sapiens 170-174 18222974-9 2008 In addition, MEVA attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated secretion of tumor necrosis factor-alpha, interleukin-6 (IL-6), and IL-8 in human mast cells. Tetradecanoylphorbol Acetate 33-64 interleukin 6 Homo sapiens 155-168 18222974-9 2008 In addition, MEVA attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated secretion of tumor necrosis factor-alpha, interleukin-6 (IL-6), and IL-8 in human mast cells. Tetradecanoylphorbol Acetate 33-64 interleukin 6 Homo sapiens 170-174 18222974-9 2008 In addition, MEVA attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated secretion of tumor necrosis factor-alpha, interleukin-6 (IL-6), and IL-8 in human mast cells. Calcium 69-76 interleukin 6 Homo sapiens 155-168 18222974-9 2008 In addition, MEVA attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated secretion of tumor necrosis factor-alpha, interleukin-6 (IL-6), and IL-8 in human mast cells. Calcium 69-76 interleukin 6 Homo sapiens 170-174 18222974-9 2008 In addition, MEVA attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated secretion of tumor necrosis factor-alpha, interleukin-6 (IL-6), and IL-8 in human mast cells. pmaci 95-100 interleukin 6 Homo sapiens 155-168 18204781-4 2008 Treatment of cells with interleukin-6 neutralizing antibody inhibited the phosphorylation of STAT3 Tyr 705 and Ser 727. Tyrosine 99-102 interleukin 6 Homo sapiens 24-37 18204781-4 2008 Treatment of cells with interleukin-6 neutralizing antibody inhibited the phosphorylation of STAT3 Tyr 705 and Ser 727. Serine 111-114 interleukin 6 Homo sapiens 24-37 17720160-5 2008 It is now known that the effects of cAMP are transcription dependent, and that cAMP-mediated activation of CREB leads to upregulated expression of genes such as arginase I and interleukin-6. Cyclic AMP 36-40 interleukin 6 Homo sapiens 176-189 17720160-5 2008 It is now known that the effects of cAMP are transcription dependent, and that cAMP-mediated activation of CREB leads to upregulated expression of genes such as arginase I and interleukin-6. Cyclic AMP 79-83 interleukin 6 Homo sapiens 176-189 18344152-12 2008 Chronic treatment with carvedilol improves LV systolic function, exercise tolerance and peak oxygen consumption and is associated with significant decrease of BNP, ET-1, TNF-alpha and IL-6 concentrations. Carvedilol 23-33 interleukin 6 Homo sapiens 184-188 17993646-4 2008 Here we show that rapamycin, the inhibitor of mTOR signaling, rescues insulin signaling and glycogen synthesis from IL-6 inhibition in HepG2 hepatocarcinoma cells as well as in mouse primary hepatocytes. Sirolimus 18-27 interleukin 6 Homo sapiens 116-120 18279213-8 2008 Serum IL-6 levels in patients with ADV infection on day 4 of hospitalization were significantly higher than those in patients without steroids treatment or in patients with RSV infection. Steroids 134-142 interleukin 6 Homo sapiens 6-10 18279213-10 2008 CONCLUSION: Patients with ADV infections who were given steroids had a temporary increase of IL-6, which might have indicated the development of a severe clinical course if not been administered. Steroids 56-64 interleukin 6 Homo sapiens 93-97 18211669-1 2008 BACKGROUND: Because of the possible role of cytokines including interleukins (IL) in systemic non-thyroidal illnesses" (NTI) pathogenesis and consequently the frequently associated alterations in thyroid hormone (TH) concentrations constituting the euthyroid sick syndrome (ESS), we aimed in this research to elucidate the possible relation between IL-6 & IL-10 and any documented ESS in a cohort of patients with NTI. Adenosine Monophosphate 355-358 interleukin 6 Homo sapiens 349-353 18211669-6 2008 Further, IL-6 was substantially higher above controls" levels (105.18 +/- 72.01 vs 3.35 +/- 1.18 ng/L, p < 0.00001) and correlated negatively with both T3 and T4 (r = -0.620, p < 0.0001 & -0.267, p < 0.001, respectively). Adenosine Monophosphate 193-196 interleukin 6 Homo sapiens 9-13 18211669-9 2008 Moreover, IL-6 (R2 = 0.338, p = 0.001) and not IL-10 was a predictor of low T3 levels with only a borderline significance for T4 (R2 = 0.082, p = 0.071).By subgroup analysis, the proportion of patients with subnormal T3, T4, and TSH levels was highest in the MI patients (70%, 70%, and 72%, respectively) who displayed the greatest IL-6 and IL-10 concentrations (192.5 +/- 45.1 ng/L & 122.95 +/- 46.1 ng/L, respectively) compared with CHF (82.95 +/- 28.9 ng/L & 69.05 +/- 44.0 ng/L, respectively) and CRI patients (40.05 +/- 28.9 ng/L & 30.4 +/- 10.6 ng/L, respectively). Adenosine Monophosphate 384-387 interleukin 6 Homo sapiens 10-14 18211669-9 2008 Moreover, IL-6 (R2 = 0.338, p = 0.001) and not IL-10 was a predictor of low T3 levels with only a borderline significance for T4 (R2 = 0.082, p = 0.071).By subgroup analysis, the proportion of patients with subnormal T3, T4, and TSH levels was highest in the MI patients (70%, 70%, and 72%, respectively) who displayed the greatest IL-6 and IL-10 concentrations (192.5 +/- 45.1 ng/L & 122.95 +/- 46.1 ng/L, respectively) compared with CHF (82.95 +/- 28.9 ng/L & 69.05 +/- 44.0 ng/L, respectively) and CRI patients (40.05 +/- 28.9 ng/L & 30.4 +/- 10.6 ng/L, respectively). Adenosine Monophosphate 465-468 interleukin 6 Homo sapiens 10-14 18211669-9 2008 Moreover, IL-6 (R2 = 0.338, p = 0.001) and not IL-10 was a predictor of low T3 levels with only a borderline significance for T4 (R2 = 0.082, p = 0.071).By subgroup analysis, the proportion of patients with subnormal T3, T4, and TSH levels was highest in the MI patients (70%, 70%, and 72%, respectively) who displayed the greatest IL-6 and IL-10 concentrations (192.5 +/- 45.1 ng/L & 122.95 +/- 46.1 ng/L, respectively) compared with CHF (82.95 +/- 28.9 ng/L & 69.05 +/- 44.0 ng/L, respectively) and CRI patients (40.05 +/- 28.9 ng/L & 30.4 +/- 10.6 ng/L, respectively). Adenosine Monophosphate 465-468 interleukin 6 Homo sapiens 10-14 18205904-3 2008 We therefore have evaluated the effect of IL-6 modulators, i.e. IL-1beta, prostaglandin E2, 17beta-estradiol, and 1,25-dihydroxyvitamin D3, on expression and synthesis of the cytokine at different stages of tumour progression. Dinoprostone 74-90 interleukin 6 Homo sapiens 42-46 18205904-3 2008 We therefore have evaluated the effect of IL-6 modulators, i.e. IL-1beta, prostaglandin E2, 17beta-estradiol, and 1,25-dihydroxyvitamin D3, on expression and synthesis of the cytokine at different stages of tumour progression. Estradiol 92-108 interleukin 6 Homo sapiens 42-46 18205904-8 2008 Addition of IL-1beta (5 ng/ml) to a COGA-13 culture raised IL-6 production approximately thousandfold via a prostaglandin-independent mechanism. Prostaglandins 108-121 interleukin 6 Homo sapiens 59-63 18205904-9 2008 Addition of 17beta-estradiol (10-7 M) reduced basal IL-6 production by one-third, but IL-1beta-inducible IL-6 was unaffected. Estradiol 12-28 interleukin 6 Homo sapiens 52-56 18205904-13 2008 CONCLUSION: In human colon carcinoma cells derived from well and moderately differentiated tumours, IL-6 expression is low and only marginally affected, if at all, by PGE2, 1,25-dihydroxyvitamin D3, and 17beta-estradiol. Estradiol 203-219 interleukin 6 Homo sapiens 100-104 17993646-6 2008 Interestingly, we find that the phosphorylation of STAT3 on Ser(727) and STAT3 transcriptional activity are regulated by mTOR upon IL-6 stimulation and that STAT3 is required for IL-6 inhibition of insulin signaling. Serine 60-63 interleukin 6 Homo sapiens 179-183 17993646-7 2008 Furthermore, IL-6-induced SOCS3 expression is inhibited by rapamycin, and ectopic expression of SOCS3 blocks the ability of rapamycin to enhance insulin sensitivity in the presence of IL-6. Sirolimus 59-68 interleukin 6 Homo sapiens 13-17 17993646-7 2008 Furthermore, IL-6-induced SOCS3 expression is inhibited by rapamycin, and ectopic expression of SOCS3 blocks the ability of rapamycin to enhance insulin sensitivity in the presence of IL-6. Sirolimus 124-133 interleukin 6 Homo sapiens 13-17 17993646-7 2008 Furthermore, IL-6-induced SOCS3 expression is inhibited by rapamycin, and ectopic expression of SOCS3 blocks the ability of rapamycin to enhance insulin sensitivity in the presence of IL-6. Sirolimus 124-133 interleukin 6 Homo sapiens 184-188 17993646-6 2008 Interestingly, we find that the phosphorylation of STAT3 on Ser(727) and STAT3 transcriptional activity are regulated by mTOR upon IL-6 stimulation and that STAT3 is required for IL-6 inhibition of insulin signaling. Serine 60-63 interleukin 6 Homo sapiens 131-135 18171484-2 2008 Integrating these data suggests that GABA may play a role in downregulating mechanisms that lead to the production of proinflammatory agents such as interleukin-1, interleukin-6, and matrix metalloproteinase 3 - agents implicated in the pathogenesis of rheumatoid arthritis (RA). gamma-Aminobutyric Acid 37-41 interleukin 6 Homo sapiens 164-177 19206545-7 2008 Furthermore, at 4 nm thick per layer, orders of magnitude thinner than conventional drug delivery coatings, these dexamethasone-copolymer mixtures (PolyDex) suppressed in vitro expression of the inflammatory cytokines/signaling elements interleukin 6 (IL-6), interleukin 12 (IL-12), tumor necrosis factor alpha (TNFalpha), inducible nitric oxide synthase (iNOS), and interferon gamma inducible protein (IP-10). Dexamethasone 114-127 interleukin 6 Homo sapiens 237-250 19206545-7 2008 Furthermore, at 4 nm thick per layer, orders of magnitude thinner than conventional drug delivery coatings, these dexamethasone-copolymer mixtures (PolyDex) suppressed in vitro expression of the inflammatory cytokines/signaling elements interleukin 6 (IL-6), interleukin 12 (IL-12), tumor necrosis factor alpha (TNFalpha), inducible nitric oxide synthase (iNOS), and interferon gamma inducible protein (IP-10). Dexamethasone 114-127 interleukin 6 Homo sapiens 252-256 19012528-1 2008 BACKGROUND: Biogenic amine, adrenaline, noradrenaline, dopamine and 5-hydroxy-tryptamine (5-HT) levels are related to interleukin-6 (IL-6) plasma concentrations and endurance exercise. Norepinephrine 40-53 interleukin 6 Homo sapiens 118-131 17706915-6 2008 RESULTS: Multilevel modeling showed that higher chronic interpersonal stress was associated with greater stimulated IL-6 production (p<0.05) as well as greater resistance to hydrocortisone inhibition of IL-6 production (p<0.05). Hydrocortisone 177-191 interleukin 6 Homo sapiens 206-210 19012528-1 2008 BACKGROUND: Biogenic amine, adrenaline, noradrenaline, dopamine and 5-hydroxy-tryptamine (5-HT) levels are related to interleukin-6 (IL-6) plasma concentrations and endurance exercise. Serotonin 68-88 interleukin 6 Homo sapiens 118-131 18171428-0 2008 Role of interleukin-6 signalling in glucose and lipid metabolism. Glucose 36-43 interleukin 6 Homo sapiens 8-21 18171428-7 2008 This review aims at summarizing the current data on mechanisms by which IL-6 may impact on glucose and lipid metabolism. Glucose 91-98 interleukin 6 Homo sapiens 72-76 17405871-7 2008 The cord blood cortisol concentration was significantly increased in the presence of chorioamnionitis or funisitis and was moderately correlated with cord blood IL6 (r = 0.64, p<0.01) and IL8 (r = 0.52, p<0.01). Hydrocortisone 15-23 interleukin 6 Homo sapiens 161-164 19364068-9 2008 Decreased MCP-1, IL-6, and IL-8 expression indicated that APS-purified islets were possibly exposed to less proinflammatory stress. aps 58-61 interleukin 6 Homo sapiens 17-21 19012528-1 2008 BACKGROUND: Biogenic amine, adrenaline, noradrenaline, dopamine and 5-hydroxy-tryptamine (5-HT) levels are related to interleukin-6 (IL-6) plasma concentrations and endurance exercise. Serotonin 68-88 interleukin 6 Homo sapiens 133-137 19012528-1 2008 BACKGROUND: Biogenic amine, adrenaline, noradrenaline, dopamine and 5-hydroxy-tryptamine (5-HT) levels are related to interleukin-6 (IL-6) plasma concentrations and endurance exercise. Norepinephrine 40-53 interleukin 6 Homo sapiens 133-137 19012528-1 2008 BACKGROUND: Biogenic amine, adrenaline, noradrenaline, dopamine and 5-hydroxy-tryptamine (5-HT) levels are related to interleukin-6 (IL-6) plasma concentrations and endurance exercise. Dopamine 55-63 interleukin 6 Homo sapiens 118-131 19012528-1 2008 BACKGROUND: Biogenic amine, adrenaline, noradrenaline, dopamine and 5-hydroxy-tryptamine (5-HT) levels are related to interleukin-6 (IL-6) plasma concentrations and endurance exercise. Dopamine 55-63 interleukin 6 Homo sapiens 133-137 18068095-5 2008 OK-TX-ppt exerted no TLR2-mediated activity, but induced interleukin (IL)-6 in human PBMC. -ppt 5-9 interleukin 6 Homo sapiens 57-75 19075734-7 2008 IL-6 can be induced by a variety of molecules including IL-1, TNF-alpha, transforming growth factor-beta and prostaglandins (PGs), and many other mediators such as b-amyloid, interferon-g (IFNg) and IL-4 can potentiate these primary inducers, highlighting the complex nature of IL-6 modulation. Prostaglandins 109-123 interleukin 6 Homo sapiens 0-4 19075734-7 2008 IL-6 can be induced by a variety of molecules including IL-1, TNF-alpha, transforming growth factor-beta and prostaglandins (PGs), and many other mediators such as b-amyloid, interferon-g (IFNg) and IL-4 can potentiate these primary inducers, highlighting the complex nature of IL-6 modulation. Prostaglandins 125-128 interleukin 6 Homo sapiens 0-4 18588355-13 2008 Similarly, patients receiving atorvastatin or NCB-02 showed significant reductions in the levels of malondialdehyde, ET-1, IL-6 and TNFalpha. Atorvastatin 30-42 interleukin 6 Homo sapiens 123-127 17981627-4 2008 Inflammatory response after stroke suggests that cytokines (TNF-alpha, IL-1alpha/beta, IL-6), affect the phospholipid metabolism and subsequent production of eicosanoids, ceramide, and ROS that may potentiate brain injury. Phospholipids 105-117 interleukin 6 Homo sapiens 87-91 17981627-4 2008 Inflammatory response after stroke suggests that cytokines (TNF-alpha, IL-1alpha/beta, IL-6), affect the phospholipid metabolism and subsequent production of eicosanoids, ceramide, and ROS that may potentiate brain injury. Eicosanoids 158-169 interleukin 6 Homo sapiens 87-91 17981627-4 2008 Inflammatory response after stroke suggests that cytokines (TNF-alpha, IL-1alpha/beta, IL-6), affect the phospholipid metabolism and subsequent production of eicosanoids, ceramide, and ROS that may potentiate brain injury. ros 185-188 interleukin 6 Homo sapiens 87-91 18260364-10 2008 Besides adrenal androgen blockade, dexamethasone suppresses the growth of prostate cancer via NFkappaB inactivation, and also via the inhibition of interleukin-6 production which is reportedly important for the growth of prostate cancer. Dexamethasone 35-48 interleukin 6 Homo sapiens 148-161 18668392-8 2008 Dexamethasone enhanced IL-10 (p = 0.013) and suppressed IL-1beta, TNF-alpha, interleukin 6 (IL-6), and interleukin 8 (IL-8) (p = 0.013). Dexamethasone 0-13 interleukin 6 Homo sapiens 77-90 18668392-8 2008 Dexamethasone enhanced IL-10 (p = 0.013) and suppressed IL-1beta, TNF-alpha, interleukin 6 (IL-6), and interleukin 8 (IL-8) (p = 0.013). Dexamethasone 0-13 interleukin 6 Homo sapiens 92-96 18345501-0 2008 The synergistic effect of histamine and IL-6 on NGF secretion from cultured astrocytes is evoked by histamine stimulation of IL-6 secretion via H1-receptor-PKC-MAPK signalling pathway. Histamine 26-35 interleukin 6 Homo sapiens 125-129 18345501-0 2008 The synergistic effect of histamine and IL-6 on NGF secretion from cultured astrocytes is evoked by histamine stimulation of IL-6 secretion via H1-receptor-PKC-MAPK signalling pathway. Histamine 100-109 interleukin 6 Homo sapiens 40-44 18345501-0 2008 The synergistic effect of histamine and IL-6 on NGF secretion from cultured astrocytes is evoked by histamine stimulation of IL-6 secretion via H1-receptor-PKC-MAPK signalling pathway. Histamine 100-109 interleukin 6 Homo sapiens 125-129 17911176-8 2008 The low testosterone-mortality association was also independent of the metabolic syndrome, diabetes, and prevalent cardiovascular disease but was attenuated by adjustment for IL-6 and C-reactive protein. Testosterone 8-20 interleukin 6 Homo sapiens 175-179 17965029-6 2008 A significant inhibitory effect of besifloxacin was observed at 0.1 mg/L for IL-1alpha, at 1 mg/L for G-CSF, IL-1ra and IL-6 and at 30 mg/L for GM-CSF, IL-12p40, IL-1beta, IL-8, IP-10, MCP-1 and MIP-1alpha. besifloxacin 35-47 interleukin 6 Homo sapiens 120-124 18209571-10 2008 LPS-induced IL-6 promoter activation was also prevented by pretreatment with epigallocatechin 3-gallate, curcumin, and resveratrol. Curcumin 105-113 interleukin 6 Homo sapiens 12-16 18209571-10 2008 LPS-induced IL-6 promoter activation was also prevented by pretreatment with epigallocatechin 3-gallate, curcumin, and resveratrol. Resveratrol 119-130 interleukin 6 Homo sapiens 12-16 17766053-3 2008 IL-6 controls systemic iron homeostasis through hepcidin, which is produced mainly by hepatocytes. Iron 23-27 interleukin 6 Homo sapiens 0-4 17716784-4 2008 Under certain conditions, however, stress hormones, substance P, ATP and the activation of the corticotropin-releasing hormone/substance P-histamine axis may actually facilitate inflammation, through induction of interleukin (IL)-1, IL-6, IL-8, IL-18, tumor necrosis factor (TNF)-alpha and CRP production. Histamine 139-148 interleukin 6 Homo sapiens 233-237 17956545-5 2008 On the other hand, IL-6 produced in the working muscle during physical activity could act as an energy sensor by activating AMP-activated kinase and enhancing glucose disposal, lipolysis and fat oxidation. Glucose 159-166 interleukin 6 Homo sapiens 19-23 18679047-4 2008 Melatonin not only stimulates the production of natural killer cells, monocytes and leukocytes, but also alters the balance of T helper (Th)-1 and Th-2 cells mainly towards Th-1 responses and increases the production of relevant cytokines such as interleukin (IL)-2, IL-6, IL-12 and interferon-gamma. Melatonin 0-9 interleukin 6 Homo sapiens 267-271 20016733-9 2008 The subjects with higher initial total cholesterol and LDL-cholesterol level showed higher reduction in plasma concentrations of total cholesterol, LDL-cholesterol, IL-6, and blood pressure. Cholesterol 39-50 interleukin 6 Homo sapiens 165-169 20016733-9 2008 The subjects with higher initial total cholesterol and LDL-cholesterol level showed higher reduction in plasma concentrations of total cholesterol, LDL-cholesterol, IL-6, and blood pressure. Cholesterol 59-70 interleukin 6 Homo sapiens 165-169 20016733-9 2008 The subjects with higher initial total cholesterol and LDL-cholesterol level showed higher reduction in plasma concentrations of total cholesterol, LDL-cholesterol, IL-6, and blood pressure. Cholesterol 59-70 interleukin 6 Homo sapiens 165-169 20016733-9 2008 The subjects with higher initial total cholesterol and LDL-cholesterol level showed higher reduction in plasma concentrations of total cholesterol, LDL-cholesterol, IL-6, and blood pressure. Cholesterol 59-70 interleukin 6 Homo sapiens 165-169 19116667-7 2008 Similarly, chelating intracellular calcium ([Ca(2+)](i)) blocked Tat+/-morphine-evoked MCP-1 and IL-6 release, while artificially increasing the concentration of extracellular Ca(2+) reversed this effect. Calcium 35-42 interleukin 6 Homo sapiens 97-101 18846238-6 2008 Increases in H2O2 heavily contributed to the excessive IL-6 and IL-8 production in CF epithelia. Hydrogen Peroxide 13-17 interleukin 6 Homo sapiens 55-59 18846238-8 2008 When cells are stimulated, differential expression in CF versus normal is enhanced; corresponding to an increase in H2O2 mediated production of IL-6 and IL-8. Hydrogen Peroxide 116-120 interleukin 6 Homo sapiens 144-148 18846238-11 2008 We conclude that a paradoxical decrease in Nrf-2 driven antioxidant responses in CF epithelia results in an increase in steady state H2O2, which in turn contributes to the overproduction of the pro-inflammatory cytokines IL-6 and IL-8. Hydrogen Peroxide 133-137 interleukin 6 Homo sapiens 221-225 19116667-5 2008 Pretreatment with the NF-kappaB inhibitor parthenolide provided evidence that Tat+/-morphine-induced release of MCP-1, IL-6 and TNF-alpha by astrocytes is NF-kappaB dependent. parthenolide 42-54 interleukin 6 Homo sapiens 119-123 19116667-5 2008 Pretreatment with the NF-kappaB inhibitor parthenolide provided evidence that Tat+/-morphine-induced release of MCP-1, IL-6 and TNF-alpha by astrocytes is NF-kappaB dependent. Morphine 84-92 interleukin 6 Homo sapiens 119-123 19116667-7 2008 Similarly, chelating intracellular calcium ([Ca(2+)](i)) blocked Tat+/-morphine-evoked MCP-1 and IL-6 release, while artificially increasing the concentration of extracellular Ca(2+) reversed this effect. Morphine 71-79 interleukin 6 Homo sapiens 97-101 17996694-2 2007 Using MACS-purified CD4 cells, we found that rapamycin and cyclosporine A (CsA) potently inhibited the TGFbeta and IL-6-induced generation of IL-17-producing cells. Sirolimus 45-54 interleukin 6 Homo sapiens 115-119 18158367-6 2008 GC sensitivity was measured by dexamethasone inhibition of lipopolysaccharide-induced interleukin-6 and tumor necrosis factor-alpha production in whole blood. Dexamethasone 31-44 interleukin 6 Homo sapiens 86-131 17956865-3 2007 IL-6 induces rapid nuclear translocation of Tyr-phosphorylated STAT3 that forms a nuclear complex with CDK9 in nondenaturing co-immunoprecipitation and confocal colocalization assays. Tyrosine 44-47 interleukin 6 Homo sapiens 0-4 17785586-3 2007 Here we demonstrate that PPARgamma agonists 15-d-PGJ2 and troglitazone significantly suppress cell-cell adhesive events, including expression of adhesion molecules and IL-6 secretion from BMSCs triggered by adhesion of MM cells, as well as overcome drug resistance by a PPARgamma-dependent mechanism. 15-deoxyprostaglandin J2 44-53 interleukin 6 Homo sapiens 168-172 17823310-5 2007 We demonstrate that IL-6 induces the phosphorylation of the C-terminal tyrosine residue of the HGAL protein via the Lyn kinase, and promotes its relocalization from the cytoplasm to podosome-like structures. Tyrosine 71-79 interleukin 6 Homo sapiens 20-24 17967414-6 2007 Resveratrol effectively reversed the secretion and mRNA expression of the atherogenic adipokines, PAI-1 and IL-6, induced by TNF-alpha. Resveratrol 0-11 interleukin 6 Homo sapiens 108-112 17996694-2 2007 Using MACS-purified CD4 cells, we found that rapamycin and cyclosporine A (CsA) potently inhibited the TGFbeta and IL-6-induced generation of IL-17-producing cells. Cyclosporine 59-73 interleukin 6 Homo sapiens 115-119 17996694-2 2007 Using MACS-purified CD4 cells, we found that rapamycin and cyclosporine A (CsA) potently inhibited the TGFbeta and IL-6-induced generation of IL-17-producing cells. Cyclosporine 75-78 interleukin 6 Homo sapiens 115-119 17987036-10 2007 Prevention of IL-6 trans-signalling using soluble gp130 reduced curability. 2-phenyl-5,5-dimethyltetrahydro-1,4-oxazine 50-55 interleukin 6 Homo sapiens 14-18 18082089-7 2007 Pharmacological treatment with either rosuvastatin or metformin lead to reductions in IL-6, TNFalpha, GSH and GPx levels and an increase in the SOD level, and there were significant interactions between the two treatment groups for these variables. Metformin 54-63 interleukin 6 Homo sapiens 86-90 18156658-0 2007 Effect of carbohydrate intake during recovery from eccentric exercise on interleukin-6 and muscle-damage markers. Carbohydrates 10-22 interleukin 6 Homo sapiens 73-86 18156658-1 2007 The purpose of this investigation was to determine whether carbohydrate supplementation during the first 2 d postexercise recovery influenced the inflammation (IL-6, C-reactive protein [CRP], and cortisol) and muscle-damage responses. Carbohydrates 59-71 interleukin 6 Homo sapiens 160-164 17953698-4 2007 IL-6 concentrations in mouthwash, collected by rinsing with 3 ml saline for 30 s and in serum, obtained by venipuncture, were measured using ELISA. Sodium Chloride 65-71 interleukin 6 Homo sapiens 0-4 18166692-7 2007 We examined IL-6 level as a function of vitamin D status using generalized estimating equations, adjusting for covariates. Vitamin D 40-49 interleukin 6 Homo sapiens 12-16 18166692-8 2007 RESULTS: Women deficient in vitamin D at baseline had higher IL-6 levels in the year postfracture (p=.02). Vitamin D 28-37 interleukin 6 Homo sapiens 61-65 18166692-10 2007 CONCLUSIONS: Women with vitamin D deficiency at the time of hip fracture had higher serum IL-6 levels in the year after hip fracture. Vitamin D 24-33 interleukin 6 Homo sapiens 90-94 17609976-8 2007 The secretion of IL-6, leptin, MIF and VEGF from the adipocytes was also stimulated by exposure to 1% O(2). Oxygen 102-106 interleukin 6 Homo sapiens 17-21 17694420-6 2007 Both IL6 polymorphisms were associated with significant interaction with current use of aspirin/NSAIDs to alter risk of colon cancer: individuals with a C allele in either polymorphism who were current users of aspirin/NSAIDs had the lowest colon cancer risk. Aspirin 88-95 interleukin 6 Homo sapiens 5-8 17694420-6 2007 Both IL6 polymorphisms were associated with significant interaction with current use of aspirin/NSAIDs to alter risk of colon cancer: individuals with a C allele in either polymorphism who were current users of aspirin/NSAIDs had the lowest colon cancer risk. Aspirin 211-218 interleukin 6 Homo sapiens 5-8 17694420-7 2007 CRC risk also was associated with an interaction between VDR and IL6 genotypes that was modified by current use of aspirin/NSAIDs. Aspirin 115-122 interleukin 6 Homo sapiens 65-68 18203069-9 2007 In addition, exposure to icodextrin-PDF impaired viability and IL-6 release from HPMC. hydroxypropylmethylcellulose-lactose matrix 81-85 interleukin 6 Homo sapiens 63-67 17761160-3 2007 FK506 and cyclosporine A, calcineurin inhibitors, partially inhibited UTP-induced IL-6 mRNA expression and protein production. Cyclosporine 10-24 interleukin 6 Homo sapiens 82-86 18022595-9 2007 Synthesis of Il-6, vascular endothelial growth factor (VEGF), transforming growth factor beta (TGFbeta), and fibronectin was higher in GLU group as compared with control: + 86%, P < 0.001, +38%, P < 0.05, +51%, P < 0.001, +38%, P < 0.05, respectively. Glutamic Acid 135-138 interleukin 6 Homo sapiens 13-17 17761160-4 2007 In addition, combined application of FK506 and PD98059 synergistically inhibited the UTP-induced IL-6 production. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 47-54 interleukin 6 Homo sapiens 97-101 17720876-9 2007 However, the PKCepsilon inhibitor, Ro 31-8220, effectively inhibited FLDE-stimulated IL-8 and IL-6 release. Ro 31-8220 35-45 interleukin 6 Homo sapiens 94-98 17980786-6 2007 Alcohol-induced endothelial damage or protection may be related to the synthesis or action of several markers, such as nitric oxide, cortisol, endothelin-1, adhesion molecules, tumor necrosis factor alpha, interleukin-6, C-reactive protein, and haemostatic factors. Alcohols 0-7 interleukin 6 Homo sapiens 206-219 17956334-6 2007 In more recent experiments, it has been shown that IL-6 infusion increases glucose disposal during a hyperinsulinaemic euglycaemic clamp in healthy humans. Glucose 75-82 interleukin 6 Homo sapiens 51-55 17956334-7 2007 IL-6 treatment of myotubes increases fatty acid oxidation, basal and insulin-stimulated glucose uptake and translocation of GLUT4 to the plasma membrane. Fatty Acids 37-47 interleukin 6 Homo sapiens 0-4 17956334-7 2007 IL-6 treatment of myotubes increases fatty acid oxidation, basal and insulin-stimulated glucose uptake and translocation of GLUT4 to the plasma membrane. Glucose 88-95 interleukin 6 Homo sapiens 0-4 17553644-4 2007 We applied human recombinant IL-6 intra-nasally to developing rats 1h before seizures induced by moist heated air (50 degrees C). Hydrogen 67-69 interleukin 6 Homo sapiens 29-33 17644736-6 2007 The iron-responsive region that we have mapped is the same region required for the in vitro response of HepG2 cells to stimulation with bone morphogenetic proteins and differs from the LPS/IL-6 responsive area. Iron 4-8 interleukin 6 Homo sapiens 189-193 17891168-10 2007 The anti-inflammatory glucocorticoid, dexamethasone, inhibited the histamine enhanced NF-kappaB-dependent transcription and IL-6 and IL-8 release. Dexamethasone 38-51 interleukin 6 Homo sapiens 124-128 17891168-10 2007 The anti-inflammatory glucocorticoid, dexamethasone, inhibited the histamine enhanced NF-kappaB-dependent transcription and IL-6 and IL-8 release. Histamine 67-76 interleukin 6 Homo sapiens 124-128 17553644-10 2007 These results indicate that IL-6 plays an anti-convulsive role through the adenosine system in hyperthermia-induced seizures, which might be relevant as to human febrile seizures. Adenosine 75-84 interleukin 6 Homo sapiens 28-32 17450584-12 2007 Thus, SP and Ti particles acted synergistically to increase PGE2 and IL-6 secretion in fibroblasts from periprosthetic membrane. Titanium 13-15 interleukin 6 Homo sapiens 69-73 17716862-2 2007 IL-6 initiates its action by binding to its cell surface receptor, followed by activation of Janus kinases and tyrosine phosphorylation of the signal transducer and transcription factor (STAT) 3. Tyrosine 111-119 interleukin 6 Homo sapiens 0-4 17716862-4 2007 Here we show that pretreatment of HepG2 hepatoma cells with methyl-beta-cyclodextrin (MbetaCD), which removes cholesterol and destroys lipid rafts, inhibited tyrosine phosphorylation of STAT3 in IL-6-activated, but not PV-activated cells. methyl-beta-cyclodextrin 60-84 interleukin 6 Homo sapiens 195-199 17716862-4 2007 Here we show that pretreatment of HepG2 hepatoma cells with methyl-beta-cyclodextrin (MbetaCD), which removes cholesterol and destroys lipid rafts, inhibited tyrosine phosphorylation of STAT3 in IL-6-activated, but not PV-activated cells. methyl-beta-cyclodextrin 86-93 interleukin 6 Homo sapiens 195-199 17716862-4 2007 Here we show that pretreatment of HepG2 hepatoma cells with methyl-beta-cyclodextrin (MbetaCD), which removes cholesterol and destroys lipid rafts, inhibited tyrosine phosphorylation of STAT3 in IL-6-activated, but not PV-activated cells. Tyrosine 158-166 interleukin 6 Homo sapiens 195-199 17716862-6 2007 Although most of the STAT3 was found in large MbetaCD-resistant assemblies in both non-activated and IL-6-activated cells, its association with lipid rafts was weak or undetectable. methyl-beta-cyclodextrin 46-53 interleukin 6 Homo sapiens 101-105 17716862-7 2007 The extent of IL-6-induced tyrosine phosphorylation of STAT3 was comparable in cells expressing low or high levels of caveolin. Tyrosine 27-35 interleukin 6 Homo sapiens 14-18 17450584-0 2007 Substance P augments PGE2 and IL-6 production in titanium particles-stimulated fibroblasts from hip periprosthetic membrane. Titanium 49-57 interleukin 6 Homo sapiens 30-34 18070750-4 2007 RESULTS: Incubation of macrophages with heparin- or insulin-treated adipocyte CM increased tumor necrosis factor alpha, interleukin-6, and nitric oxide production by these cells. Heparin 40-47 interleukin 6 Homo sapiens 120-133 17188378-7 2007 HDL-cholesterol levels were inversely correlated to the hs-CRP levels (b=-0.028, P=0.001) and homocysteine levels (b=-0.039, P=0.036), after adjustment for sex, age, body mass index, physical activity status, smoking, total cholesterol levels, lipid lower agents, ethanol intake and diabetes mellitus; while no statistical significance was found between HDL-cholesterol levels and interleukin-6 and serum amyloid-a. Cholesterol 4-15 interleukin 6 Homo sapiens 381-394 17683978-17 2007 The results from a partial least-square regression analysis predicted that both PAHs and a group of metals including Fe and Mn contributed to IL-6 and IL-8 induction. Iron 117-119 interleukin 6 Homo sapiens 142-146 17716980-3 2007 Here we show that stress hormones such as norepinephrine lead to increased expression of IL-6 mRNA and protein levels in ovarian carcinoma cells. Norepinephrine 42-56 interleukin 6 Homo sapiens 89-93 17716980-4 2007 Furthermore, we demonstrate that norepinephrine stimulation activates Src tyrosine kinase and this activation is required for increased IL-6 expression. Norepinephrine 33-47 interleukin 6 Homo sapiens 136-140 17675586-5 2007 Among the 2000-compound National Cancer Institute Diversity set, we identified 8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008) as a micromolar inhibitor of interleukin-6 or oncostatin-induced STAT3 nuclear translocation. 8-benzyl-4-oxo-8-azabicyclo(3.2.1)oct-2-ene-6,7-dicarboxylic acid 79-144 interleukin 6 Homo sapiens 184-197 17675586-5 2007 Among the 2000-compound National Cancer Institute Diversity set, we identified 8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008) as a micromolar inhibitor of interleukin-6 or oncostatin-induced STAT3 nuclear translocation. 8-benzyl-4-oxo-8-azabicyclo(3.2.1)oct-2-ene-6,7-dicarboxylic acid 146-153 interleukin 6 Homo sapiens 184-197 17644731-3 2007 Growth and survival cytokines such as interleukin-6 (IL-6) and insulin-like growth factor-I (IGF-I), which could protect myeloma cells from dexamethasone-induced apoptosis, did not affect mAb-mediated cell death. Dexamethasone 140-153 interleukin 6 Homo sapiens 38-51 17581928-7 2007 On the other hand, IL-6 increased the level of 5-(and-6)-chloromethyl-2",7"-dichlorodihydrofluorescein diacetate-sensitive cellular reactive oxygen species (ROS), and IL-6-induced increases in alpha-MG uptake and the protein expression level of SGLTs were blocked by ascorbic acid or taurine (antioxidants). Reactive Oxygen Species 132-155 interleukin 6 Homo sapiens 19-23 17867636-8 2007 Subsequent studies on the IL-6 formation revealed that limonene had a stimulating effect and alpha-terpineol had an inhibiting effect, whereas linalool had no effect. Limonene 55-63 interleukin 6 Homo sapiens 26-30 17880416-6 2007 Interestingly, sirolimus was shown to inhibit intracellular IL-6 production in adults (63.1 +/- 12.7% vs. 52.0 +/- 16.0%, p = 0.005), but in neonatal monocytes intracellular IL-6 expression was stimulated (53.5 +/- 22.0% vs. 64.7 +/- 19.1%, p = 0.041). Sirolimus 15-24 interleukin 6 Homo sapiens 60-64 17880416-6 2007 Interestingly, sirolimus was shown to inhibit intracellular IL-6 production in adults (63.1 +/- 12.7% vs. 52.0 +/- 16.0%, p = 0.005), but in neonatal monocytes intracellular IL-6 expression was stimulated (53.5 +/- 22.0% vs. 64.7 +/- 19.1%, p = 0.041). Sirolimus 15-24 interleukin 6 Homo sapiens 174-178 17880416-8 2007 Sirolimus was demonstrated to have a distinct effect on neonatal immune cells as shown by increased expression of IL-2 in lymphocytes and IL-6 in monocytes, while only lymphocytic TNF-alpha expression was inhibited. Sirolimus 0-9 interleukin 6 Homo sapiens 138-142 17581928-11 2007 A pretreatment with SN50 or BAY 11-7082 also blocked the IL-6-induced increase in alpha-MG uptake. SN50 20-24 interleukin 6 Homo sapiens 57-61 17581928-12 2007 In conclusion, IL-6 increases the SGLT activity through ROS, and its action in renal PTCs is associated with the STAT3, PI3K/Akt, MAPKs, and NF-kappaB signaling pathways. Reactive Oxygen Species 56-59 interleukin 6 Homo sapiens 15-19 17581928-7 2007 On the other hand, IL-6 increased the level of 5-(and-6)-chloromethyl-2",7"-dichlorodihydrofluorescein diacetate-sensitive cellular reactive oxygen species (ROS), and IL-6-induced increases in alpha-MG uptake and the protein expression level of SGLTs were blocked by ascorbic acid or taurine (antioxidants). Reactive Oxygen Species 157-160 interleukin 6 Homo sapiens 19-23 17917251-5 2007 Taken together, our findings demonstrate that endogenous STAT3 is acetylated at Lys-685 by LIF or IL-6 through PI3K/Akt activation. Lysine 80-83 interleukin 6 Homo sapiens 98-102 18059606-3 2007 IL-6 increases insulin-stimulated glucose disposal and fatty acid oxidation in humans in vivo. Glucose 34-41 interleukin 6 Homo sapiens 0-4 18059606-3 2007 IL-6 increases insulin-stimulated glucose disposal and fatty acid oxidation in humans in vivo. Fatty Acids 55-65 interleukin 6 Homo sapiens 0-4 17141246-3 2007 The objectives of this study were to examine the influence of PPAR gamma and its agonist (rosiglitazone) on the TNFalpha, IL-6, IL-8 and IL-10 gene expression in monocytes of patients with diabetic macroangiopathy and to analyse obtained results in context of selected atherogenic factors ant direct indicators of endothelial lesion. Rosiglitazone 90-103 interleukin 6 Homo sapiens 122-126 17917251-0 2007 LIF- and IL-6-induced acetylation of STAT3 at Lys-685 through PI3K/Akt activation. Lysine 46-49 interleukin 6 Homo sapiens 9-13 17786306-12 2007 Cepharanthin inhibited the production of IR-induced IL-6 and IL-8, which are downstream targets of NF-kappaB. cepharanthine 0-12 interleukin 6 Homo sapiens 52-56 17705048-0 2007 Adenosine inhibition of lipopolysaccharide-induced interleukin-6 secretion by the osteoblastic cell line MG-63. Adenosine 0-9 interleukin 6 Homo sapiens 51-64 17705048-3 2007 In order to assess whether adenosine has anti-inflammatory actions in osteoblastic cells, we investigated its effects on lipopolysaccharide (LPS)-induced interleukin 6 (IL-6) release in an in vitro inflammatory functional response model. Adenosine 27-36 interleukin 6 Homo sapiens 154-167 17705048-3 2007 In order to assess whether adenosine has anti-inflammatory actions in osteoblastic cells, we investigated its effects on lipopolysaccharide (LPS)-induced interleukin 6 (IL-6) release in an in vitro inflammatory functional response model. Adenosine 27-36 interleukin 6 Homo sapiens 169-173 17666475-9 2007 This ghrelin peak occurred 30 min after the TNF-alpha peak and corresponded with IL-6, GH, and ACTH peaks. Ghrelin 5-12 interleukin 6 Homo sapiens 81-85 17875759-3 2007 Here, we test the hypothesis that bile acids and gastric acids, two components of refluxate associated with gastresophageal reflux disease, activate the IL-6/STAT3 pathway. Bile Acids and Salts 34-44 interleukin 6 Homo sapiens 153-157 17763273-1 2007 OBJECTIVES: We aimed to evaluate the effect of intravenous administration of tocolytic therapy with an oxytocin antagonist drug (atosiban) on maternal serum interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) levels in women with threatened preterm labor. atosiban 129-137 interleukin 6 Homo sapiens 157-170 17763273-1 2007 OBJECTIVES: We aimed to evaluate the effect of intravenous administration of tocolytic therapy with an oxytocin antagonist drug (atosiban) on maternal serum interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) levels in women with threatened preterm labor. atosiban 129-137 interleukin 6 Homo sapiens 172-176 17785784-4 2007 In this study, we show that monocyte-derived DCs pretreated with the vitamin A derivative all-trans retinoic acid (RA) indeed acquired several attributes characteristic of mucosal DC: secretion of TGF-beta and IL-6 and the capacity to augment mucosal homing receptor expression and IgA responses in cocultured lymphocytes. Tretinoin 100-113 interleukin 6 Homo sapiens 210-214 17785784-4 2007 In this study, we show that monocyte-derived DCs pretreated with the vitamin A derivative all-trans retinoic acid (RA) indeed acquired several attributes characteristic of mucosal DC: secretion of TGF-beta and IL-6 and the capacity to augment mucosal homing receptor expression and IgA responses in cocultured lymphocytes. Tretinoin 115-117 interleukin 6 Homo sapiens 210-214 17875759-0 2007 Activation of the interleukin-6/STAT3 antiapoptotic pathway in esophageal cells by bile acids and low pH: relevance to barrett"s esophagus. Bile Acids and Salts 83-93 interleukin 6 Homo sapiens 18-31 17951402-9 2007 SP(-/-) ascites also contained high levels of interleukin-6, macrophage chemoattractant protein-1, and 8-isoprostane (prostaglandin F(2)alpha) that were positively correlated with extensive infiltration of SP(-/-) ovarian tumors and ascites with macrophages. TFF2 protein, human 0-2 interleukin 6 Homo sapiens 46-59 17785828-2 2007 After priming with IFN-gamma and stimulation with NadADelta351-405, mo-DCs strongly up-regulated maturation markers CD83, CD86, CD80, and HLA-DR, secreted moderate quantities of TNF-alpha, IL-6, and IL-8, and produced a slight, although significant, amount of IL-12p70. nadadelta351 50-62 interleukin 6 Homo sapiens 189-193 17785828-3 2007 Costimulation of mo-DCs with NadADelta351-405 and the imidoazoquinoline drug R-848, believed to mimic bacterial RNA, increased CD86 in an additive way, but strongly synergized the secretion of IL-12p70, IL-1, IL-6, TNF-alpha, and MIP-1alpha, especially after IFN-gamma priming. nadadelta351 29-41 interleukin 6 Homo sapiens 209-213 17875759-7 2007 Treatment of Seg-1 cells with media containing bile acid cocktail and acidified to pH 4 resulted in increased activation of STAT3, IL-6 secretion, and increased expression of Bcl-x(L). Bile Acids and Salts 47-56 interleukin 6 Homo sapiens 131-135 17875759-9 2007 CONCLUSIONS: The IL-6/STAT3 antiapoptotic pathway is induced by short exposure to bile acid cocktail and low pH. Bile Acids and Salts 82-91 interleukin 6 Homo sapiens 17-21 17686057-6 2007 It was further demonstrated that IL-6-induced activation of SPHK inhibited dexamethasone-induced apoptosis of MM cells. Dexamethasone 75-88 interleukin 6 Homo sapiens 33-37 17615159-2 2007 This IL-6 production is discussed as one possible mediator of the beneficial effects of physical activity on glucose and fatty acid metabolism. Glucose 109-116 interleukin 6 Homo sapiens 5-9 17615159-2 2007 This IL-6 production is discussed as one possible mediator of the beneficial effects of physical activity on glucose and fatty acid metabolism. Fatty Acids 121-131 interleukin 6 Homo sapiens 5-9 17615159-7 2007 Pharmacological activation of AMPK with 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside upregulated IL-6 mRNA expression, which was blocked by knockdown of AMPK alpha(1) and alpha(2) using small, interfering RNA (siRNA) oligonucleotides. Oligonucleotides 227-243 interleukin 6 Homo sapiens 107-111 18219763-6 2007 IL-17 binding to an IL-17 receptor expressed on epithelial, endothelial, and fibroblastic stromal cells triggers the activation of transcription factor NF-kappaB and mitogen-activated protein kinase (p-38), which in turn results in the secretion of IL-1, TNF-alpha, IL-6, IL-8, or prostaglandin E2. Dinoprostone 281-297 interleukin 6 Homo sapiens 266-270 17694576-3 2007 We now show that, in the context of TGF-beta signalling, all-trans retinoic acid (ATRA) leads to increased induction of CD4(+) T cells expressing the Treg specification factor forkhead box protein P3 (FoxP3) and decreased frequency of cells expressing IL-17, even in the presence of IL-6. Tretinoin 67-80 interleukin 6 Homo sapiens 283-287 17694576-3 2007 We now show that, in the context of TGF-beta signalling, all-trans retinoic acid (ATRA) leads to increased induction of CD4(+) T cells expressing the Treg specification factor forkhead box protein P3 (FoxP3) and decreased frequency of cells expressing IL-17, even in the presence of IL-6. Tretinoin 82-86 interleukin 6 Homo sapiens 283-287 17470570-4 2007 We hypothesized that exercise-induced nitric oxide (NO) production is an important signaling event for IL-6, IL-8, HO-1, and HSP72 expression in muscle. Nitric Oxide 38-50 interleukin 6 Homo sapiens 103-107 17668886-9 2007 IL-6 pretreatment induced the antioxidative injury proteins, ref-1 and GPX1, decreased protein oxidation, vacuolar changes and leakage of mitochondrial products, improved ATP stores, and maintained cellular ultrastructure after 87% hepatectomy. Adenosine Triphosphate 171-174 interleukin 6 Homo sapiens 0-4 17516123-2 2007 In this study, we demonstrate that cisplatin increased the early immediate release and de novo synthesis of proinflammatory cytokines, including TNF-alpha, IL-1beta, and IL-6, through the activation of ERK and NF-kappaB in HEI-OC1 cells, which are conditionally immortalized cochlear cells that express hair cell markers. Cisplatin 35-44 interleukin 6 Homo sapiens 170-174 17628646-8 2007 Dexamethasone treatment of BECs only partially suppressed IP-10 and TNF-alpha but was more effective at suppressing RANTES, IL-6, and IL-8. Dexamethasone 0-13 interleukin 6 Homo sapiens 124-128 17659756-7 2007 RESULTS: Lower concentrations of HDL cholesterol were independently associated with higher ESR (p < 0.001), IL-6 (p = 0.02), SLEDAI (p = 0.04), and TNF-alpha (p = 0.04) after adjustment for age, sex, race, body mass index, insulin sensitivity, and current use of corticosteroids or hydroxychloroquine. Cholesterol 37-48 interleukin 6 Homo sapiens 111-115 17762656-9 2007 CONCLUSION: In patients with RAS, PTRA triggers rapid transient increases in hs-CRP and IL-6; however, 1 month after PTRA, both IL-6 and ET-1 had decreased compared to before intervention, indicating beneficial effects of PTRA on inflammation and the endothelin system. ptra 34-38 interleukin 6 Homo sapiens 88-92 17876544-10 2007 Inhibitors for ERK (PD98059 and U0216) and p38 MAPK (SB203580) significantly reduced the IL-17F-induced IL-6, IL-8, LIF, MMP-1, and MMP-3 secretion. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 20-27 interleukin 6 Homo sapiens 104-108 17540857-7 2007 The effects of CdM(Hyp) on hypoxic HAECs were partially duplicated by the addition of IL-6 in a dose-dependent manner; however, anti-IL-6, anti-MCP-1, and anti-VEGF blocking antibodies added independently did not attenuate the effects. Chlorphenamidine 15-18 interleukin 6 Homo sapiens 86-90 17537833-0 2007 Interleukin-6 alters the cellular responsiveness to clopidogrel, irinotecan, and oseltamivir by suppressing the expression of carboxylesterases HCE1 and HCE2. Irinotecan 65-75 interleukin 6 Homo sapiens 0-13 17914082-10 2007 Significant correlations between the reduction in the SR peak (deltaSR) after 200 mg/m2 of epirubicin and the increase in IL-6 and ROS and decrease in GPx were observed. Epirubicin 91-101 interleukin 6 Homo sapiens 122-126 17884796-6 2007 Use of ultrapure water for 6 months significantly improved serum AOPP, MDA, GSH-Px, MPO, Alb, CRP, neopterin, and TNF-alpha levels (P<0.05), and the level of IL-6 was further reduced after 12 months (P<0.05). Water 17-22 interleukin 6 Homo sapiens 161-165 17889127-8 2007 At 3 months" posttransplant, patients treated with CyA showed significantly higher levels of IL-6 (P = .05), SAA (P = .03), and sIL-2R (P = .008) compared with patients treated with TC. Cyclosporine 51-54 interleukin 6 Homo sapiens 93-97 17889127-12 2007 CONCLUSIONS: Patients treated with CyA displayed significantly higher levels of inflammatory markers (IL-6, SAA, sIL-2R) at 3 and 12 months" posttransplantation, independent of age, gender, time on dialysis, diabetes mellitus (preRT and de novo postRT), and renal function measured by serum creatinine. Cyclosporine 35-38 interleukin 6 Homo sapiens 102-106 17560936-6 2007 Stimulation of cultured OA- and RA-SF with the TRPV1 agonist capsaicin led to increased expression of IL-6 mRNA as well as of IL-6 protein in the cell culture supernatants. Capsaicin 61-70 interleukin 6 Homo sapiens 102-106 17560936-6 2007 Stimulation of cultured OA- and RA-SF with the TRPV1 agonist capsaicin led to increased expression of IL-6 mRNA as well as of IL-6 protein in the cell culture supernatants. Capsaicin 61-70 interleukin 6 Homo sapiens 126-130 17827029-0 2007 Plasma concentration of interleukin 6 (IL-6), and its relationship with circulating concentration of dehydroepiandrosterone sulfate (DHEA-S) in patients with chronic idiopathic urticaria. Dehydroepiandrosterone Sulfate 101-131 interleukin 6 Homo sapiens 24-37 17684217-1 2007 BACKGROUND: Whether alcohol intake is associated with concentrations of interleukin-6 (IL-6) and serum amyloid P (SAP) is uncertain. Alcohols 20-27 interleukin 6 Homo sapiens 72-85 17684217-1 2007 BACKGROUND: Whether alcohol intake is associated with concentrations of interleukin-6 (IL-6) and serum amyloid P (SAP) is uncertain. Alcohols 20-27 interleukin 6 Homo sapiens 87-91 17684217-6 2007 CONCLUSIONS: Among older adults free of clinical cardiovascular disease, specific IL-6 promoter and apo E alleles appeared to confer positive associations of alcohol consumption with IL-6 concentrations. Alcohols 158-165 interleukin 6 Homo sapiens 82-86 17684217-6 2007 CONCLUSIONS: Among older adults free of clinical cardiovascular disease, specific IL-6 promoter and apo E alleles appeared to confer positive associations of alcohol consumption with IL-6 concentrations. Alcohols 158-165 interleukin 6 Homo sapiens 183-187 17665433-6 2007 Fluorescence imaging of intracellular calcium concentrations in live RA FLS stimulated with specific antagonists was used to reveal functional activation of glutamate receptors that modulated IL-6 or MMP-2. Calcium 38-45 interleukin 6 Homo sapiens 192-196 18048020-4 2007 CNTO2424 down-regulates poly(I:C)-induced production of IL-6, IL-8, MCP-1, RANTES, and IP-10 in human lung epithelial cells. Carbon 0-1 interleukin 6 Homo sapiens 56-60 17827029-0 2007 Plasma concentration of interleukin 6 (IL-6), and its relationship with circulating concentration of dehydroepiandrosterone sulfate (DHEA-S) in patients with chronic idiopathic urticaria. Dehydroepiandrosterone Sulfate 101-131 interleukin 6 Homo sapiens 39-43 17385713-0 2007 Evidence that IL-6-type cytokine signaling in cardiomyocytes is inhibited by oxidative stress: parthenolide targets JAK1 activation by generating ROS. parthenolide 95-107 interleukin 6 Homo sapiens 14-18 17521393-0 2007 Mycobacterium tuberculosis H37Rv induces monocytic release of interleukin-6 via activation of mitogen-activated protein kinases: inhibition by N-acetyl-L-cysteine. Acetylcysteine 143-162 interleukin 6 Homo sapiens 62-75 17521393-3 2007 The aim of this study was to investigate the role of mitogen-activated protein kinases in the secretion of interleukin-6 in THP-1 cells and human primary monocytes that were infected with Mycobacterium tuberculosis H37Rv, and its regulation by N-acetyl-L-cysteine, a potential antimycobacterial agent. Acetylcysteine 244-263 interleukin 6 Homo sapiens 107-120 17521393-6 2007 Pretreatment with N-acetyl-L-cysteine reduced, in a dose-dependent manner, M. tuberculosis H37Rv-induced activation of mitogen-activated protein kinase kinase 3/6 and interleukin-6 production in THP-1 cells. Acetylcysteine 18-37 interleukin 6 Homo sapiens 167-180 17385713-0 2007 Evidence that IL-6-type cytokine signaling in cardiomyocytes is inhibited by oxidative stress: parthenolide targets JAK1 activation by generating ROS. Reactive Oxygen Species 146-149 interleukin 6 Homo sapiens 14-18 17385713-8 2007 From these results, we conclude ROS generation in cardiomyocytes blocks STAT3 signaling of the IL-6-type cytokines by targeting JAK1. Reactive Oxygen Species 32-35 interleukin 6 Homo sapiens 95-99 17703129-5 2007 We propose that the protective character of IL-6-type cytokine signaling in cardiac myocytes is determined principally by three mechanisms: redox status of the nonreceptor tyrosine kinase Janus kinase 1 (JAK) 1 that activates STAT3, phosphorylation of STAT3 within the transcriptional activation domain on serine 727, and STAT3-mediated induction of suppressor of cytokine signaling (SOCS) 3 that terminates IL-6-type cytokine signaling. Serine 306-312 interleukin 6 Homo sapiens 44-48 18044343-6 2007 Melatonin reduces levels of proinflammatory cytokines: IL-6, IL-12, TNF-alpha, IFN-gamma. Melatonin 0-9 interleukin 6 Homo sapiens 55-59 17596140-5 2007 RESULTS: IL-6 was significantly associated with age, body mass index (BMI), waist circumference (WC), cigarette smoking, low physical activity, social class and alcohol intake (U-shaped). Alcohols 161-168 interleukin 6 Homo sapiens 9-13 17569825-4 2007 We identified the vitamin A metabolite retinoic acid as a key regulator of TGF-beta-dependent immune responses, capable of inhibiting the IL-6-driven induction of proinflammatory T(H)17 cells and promoting anti-inflammatory Treg cell differentiation. Tretinoin 39-52 interleukin 6 Homo sapiens 138-142 17324158-0 2007 Transcriptome profile of dendritic cells during malaria: cAMP regulation of IL-6. Cyclic AMP 57-61 interleukin 6 Homo sapiens 76-80 17324158-7 2007 We further dissected a signalling pathway regulating Plasmodium-induced expression of IL-6 by DCs, which is mediated by release of PGE2, increases in intracellular cAMP and activation of PKA and p38-MAPK. Dinoprostone 131-135 interleukin 6 Homo sapiens 86-90 17324158-7 2007 We further dissected a signalling pathway regulating Plasmodium-induced expression of IL-6 by DCs, which is mediated by release of PGE2, increases in intracellular cAMP and activation of PKA and p38-MAPK. Cyclic AMP 164-168 interleukin 6 Homo sapiens 86-90 17416792-0 2007 Interleukin-6 in obese children and adolescents with and without glucose intolerance. Glucose 65-72 interleukin 6 Homo sapiens 0-13 17442294-0 2007 Vitamin B12 and hepatic enzyme serum levels correlate with interleukin-6 in alcohol-dependent individuals without liver disease. Alcohols 76-83 interleukin 6 Homo sapiens 59-72 17442294-2 2007 The aim of the present study was to investigate the possible correlation, between liver dysfunction biological markers and vitamin B12, with interleukin-6, in the serum of alcohol-dependent individuals without liver disease (AWLD). Alcohols 172-179 interleukin 6 Homo sapiens 141-154 17442294-5 2007 The results confirmed that in alcohol-dependent individuals, the median serum concentration of IL-6, before the beginning of the treatment, had a significant positive correlation with the liver dysfunction biological markers and B12. Alcohols 30-37 interleukin 6 Homo sapiens 95-99 17442294-6 2007 In conclusion, IL-6 might be used as an additional diagnostic marker for the degree of liver dysfunction in alcohol dependent individuals. Alcohols 108-115 interleukin 6 Homo sapiens 15-19 17449045-4 2007 While inclusion of arginine during loading of IL-6 resulted in incomplete binding to the low-substituted phenyl-sepharose, binding was complete to the high-substituted phenyl-sepharose. Arginine 19-27 interleukin 6 Homo sapiens 46-50 17609399-6 2007 RESULTS: A significant negative correlation was found between E/I ratio and plasma concentrations of IL-6 (r=-0.244, P=0.032), which remained significant after adjusting for potential confounding factors (age, sex, HbA1c, WHR, diastolic BP, triglycerides, HDL-cholesterol, retinopathy, nephropathy, peripheral neuropathy, insulin dose, and smoking; r=-0.231, P=0.039). Triglycerides 241-254 interleukin 6 Homo sapiens 101-105 17609399-6 2007 RESULTS: A significant negative correlation was found between E/I ratio and plasma concentrations of IL-6 (r=-0.244, P=0.032), which remained significant after adjusting for potential confounding factors (age, sex, HbA1c, WHR, diastolic BP, triglycerides, HDL-cholesterol, retinopathy, nephropathy, peripheral neuropathy, insulin dose, and smoking; r=-0.231, P=0.039). Cholesterol 260-271 interleukin 6 Homo sapiens 101-105 17609508-4 2007 In addition, PVAE attenuated phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-alpha, IL-6, and IL-8 secretion in human mast cells. Tetradecanoylphorbol Acetate 29-60 interleukin 6 Homo sapiens 118-122 17609508-4 2007 In addition, PVAE attenuated phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-alpha, IL-6, and IL-8 secretion in human mast cells. Calcium 71-78 interleukin 6 Homo sapiens 118-122 17845991-3 2007 IL-6 seems to be implicated in androgen receptor activation in lack of steroid ligand, apoptosis decrease and increase of invasive capacity and angiogenesis via three major signaling pathways: MAPK, STAT3 and PI3K-Akt. Steroids 71-78 interleukin 6 Homo sapiens 0-4 17449045-5 2007 Arginine facilitated elution of IL-6 from both columns. Arginine 0-8 interleukin 6 Homo sapiens 32-36 17449045-6 2007 These results demonstrate that arginine weakens hydrophobic interactions between IL-6 and the phenyl-sepharose. Arginine 31-39 interleukin 6 Homo sapiens 81-85 17322416-10 2007 We further confirmed that sirolimus inhibited mRNA and protein expression of inflammatory cytokines IL-6, tumor necrosis factor-alpha, IL-8, and monocyte chemoattractant protein-1. Sirolimus 26-35 interleukin 6 Homo sapiens 100-133 17532054-0 2007 The effect of 17beta-estradiol on IL-6 secretion and NF-kappaB DNA-binding activity in human retinal pigment epithelial cells. Estradiol 14-30 interleukin 6 Homo sapiens 34-38 17532054-3 2007 In this study, we investigated the regulatory role of TLR agonists and 17beta-estradiol (E(2)) on IL-6 expression and NF-kappaB DNA-binding activity in human retinal pigment epithelial cells (ARPE-19). Estradiol 71-87 interleukin 6 Homo sapiens 98-102 17513621-7 2007 The increase in serum IL-6 levels was significantly attenuated in the morphine group compared to the fentanyl group at 3 and 24 h post-CPB (P < 0.05). Morphine 70-78 interleukin 6 Homo sapiens 22-26 17513621-10 2007 CONCLUSIONS: Compared with fentanyl, the administration of morphine as part of balanced anesthetic technique suppressed several components the inflammatory response (IL-6, CD 11b, CD 18, postoperative hyperthermia) to cardiac surgery and CPB. Morphine 59-67 interleukin 6 Homo sapiens 166-170 17363741-0 2007 Interleukin-6 directly increases glucose metabolism in resting human skeletal muscle. Glucose 33-40 interleukin 6 Homo sapiens 0-13 17637508-11 2007 AG490 as well as SB 203580 and parthenolide blocked CT-1 induced IL-6 expression completely. parthenolide 31-43 interleukin 6 Homo sapiens 65-69 17363741-10 2007 IL-6 also increased skeletal muscle glucose incorporation into glycogen, as well as glucose oxidation (1.5- and 1.3-fold, respectively; P < 0.05). Glucose 36-43 interleukin 6 Homo sapiens 0-4 17363741-13 2007 In conclusion, acute IL-6 exposure increases glucose metabolism in resting human skeletal muscle. Glucose 45-52 interleukin 6 Homo sapiens 21-25 17363741-4 2007 Thus, IL-6 has also been suggested to promote insulin-mediated glucose utilization. Glucose 63-70 interleukin 6 Homo sapiens 6-10 17363741-5 2007 In this study, we determined the direct effects of IL-6 on glucose transport and signal transduction in human skeletal muscle. Glucose 59-66 interleukin 6 Homo sapiens 51-55 17363741-8 2007 We found that IL-6 increased glucose transport in human skeletal muscle 1.3-fold (P < 0.05). Glucose 29-36 interleukin 6 Homo sapiens 14-18 17388968-3 2007 OBJECTIVES: In the present study, we evaluated the effect of various wine polyphenolic compounds and several active synthetic derivatives of resveratrol on the inflammatory cytokines (IL-1beta + IL-6)-induced CRP expression in Hep3B cells. Resveratrol 141-152 interleukin 6 Homo sapiens 195-199 17510282-1 2007 gp130-linked cytokines such as interleukin-6 (IL-6) stimulate the formation of tyrosine-phosphorylated signal transducer and activator of transcription 3 (P-STAT3), which activates many genes, including the STAT3 gene itself. Tyrosine 79-87 interleukin 6 Homo sapiens 31-44 17510282-1 2007 gp130-linked cytokines such as interleukin-6 (IL-6) stimulate the formation of tyrosine-phosphorylated signal transducer and activator of transcription 3 (P-STAT3), which activates many genes, including the STAT3 gene itself. Tyrosine 79-87 interleukin 6 Homo sapiens 46-50 17395587-6 2007 The induction of IL-6 by salmeterol was dependent upon the beta(2) receptor and could also be induced by cAMP or cAMP-elevating agents forskolin and rolipram. Cyclic AMP 113-117 interleukin 6 Homo sapiens 17-21 17160356-6 2007 It is hypothesized that cytokine release (especially interleukin-1beta, -6, -8, and TNF-alpha) due to H. pylori infection and the subsequent influx of inflammatory cells causes a massive release of reactive oxygen species (ROS) during the inflammatory reaction. Reactive Oxygen Species 198-221 interleukin 6 Homo sapiens 53-78 17160356-6 2007 It is hypothesized that cytokine release (especially interleukin-1beta, -6, -8, and TNF-alpha) due to H. pylori infection and the subsequent influx of inflammatory cells causes a massive release of reactive oxygen species (ROS) during the inflammatory reaction. Reactive Oxygen Species 223-226 interleukin 6 Homo sapiens 53-78 17395587-10 2007 The data demonstrate that beta(2) agonists can augment IL-6 expression by other stimuli in an additive manner via cyclic AMP and that the negative effect of steroids is mediated by glucocorticoid response elements within the IL-6 promoter. Cyclic AMP 114-124 interleukin 6 Homo sapiens 55-59 17395587-6 2007 The induction of IL-6 by salmeterol was dependent upon the beta(2) receptor and could also be induced by cAMP or cAMP-elevating agents forskolin and rolipram. Cyclic AMP 105-109 interleukin 6 Homo sapiens 17-21 17395587-10 2007 The data demonstrate that beta(2) agonists can augment IL-6 expression by other stimuli in an additive manner via cyclic AMP and that the negative effect of steroids is mediated by glucocorticoid response elements within the IL-6 promoter. Steroids 157-165 interleukin 6 Homo sapiens 225-229 17436234-7 2007 Levels of interleukin (IL)-6, IL-8, IL-10, interferon (IFN)-gamma, and macrophage inflammatory protein (MIP)-1beta were significantly inversely correlated with the duration of supplemental-oxygen therapy. Oxygen 189-195 interleukin 6 Homo sapiens 10-28 17468196-10 2007 There was a significant inverse correlation between baseline IL-6 and total testosterone (r=-0.68; P=0.002) and bioavailable testosterone levels (r=-0.73; P=0.007). Testosterone 76-88 interleukin 6 Homo sapiens 61-65 17346688-4 2007 METHODS: Cell proliferation, prostate-specific antigen, gene transfer, and Western blot assays were used to study the effects of sodium selenite and methylseleninic acid on IL-6 mediated AR action on an AR expressing human prostate cancer cell line, LNCaP. methylselenic acid 149-169 interleukin 6 Homo sapiens 173-177 17414493-3 2007 Accordingly, changes in calcium homeostasis, impaired glucose availability and increased formation of reactive oxygen species are all associated with exercise and capable of activating transcription factors known to regulate interleukin-6 synthesis. Calcium 24-31 interleukin 6 Homo sapiens 225-238 17414493-3 2007 Accordingly, changes in calcium homeostasis, impaired glucose availability and increased formation of reactive oxygen species are all associated with exercise and capable of activating transcription factors known to regulate interleukin-6 synthesis. Reactive Oxygen Species 102-125 interleukin 6 Homo sapiens 225-238 17414493-4 2007 Acute interleukin-6 administration to humans increases lipolysis, fat oxidation and insulin-mediated glucose disposal. Glucose 101-108 interleukin 6 Homo sapiens 6-19 17505005-0 2007 Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation. Capsaicin 0-9 interleukin 6 Homo sapiens 49-62 17505005-3 2007 EXPERIMENTAL DESIGN: The effect of capsaicin on both constitutive and interleukin-6-induced STAT3 activation, associated protein kinases, and STAT3-regulated gene products involved in proliferation, survival and angiogenesis, cellular proliferation, and apoptosis in multiple myeloma cells was investigated. Capsaicin 35-44 interleukin 6 Homo sapiens 70-83 17505005-5 2007 Capsaicin also inhibited the interleukin-6-induced STAT3 activation. Capsaicin 0-9 interleukin 6 Homo sapiens 29-42 17116726-6 2007 Silibinin also inhibited interleukin-6-induced ERK 1/2 and c-Jun phosphorylation, and cell invasiveness. Silybin 0-9 interleukin 6 Homo sapiens 25-38 17266043-5 2007 We showed that pro-inflammatory mediators including interleukin-6 (IL-6) could induce AKR1C1/1C2 expression in NSCLC cells and increase cellular resistance to cisplatin and adriamycin. Cisplatin 159-168 interleukin 6 Homo sapiens 52-65 17266043-5 2007 We showed that pro-inflammatory mediators including interleukin-6 (IL-6) could induce AKR1C1/1C2 expression in NSCLC cells and increase cellular resistance to cisplatin and adriamycin. Cisplatin 159-168 interleukin 6 Homo sapiens 67-71 17266043-5 2007 We showed that pro-inflammatory mediators including interleukin-6 (IL-6) could induce AKR1C1/1C2 expression in NSCLC cells and increase cellular resistance to cisplatin and adriamycin. Doxorubicin 173-183 interleukin 6 Homo sapiens 52-65 17266043-5 2007 We showed that pro-inflammatory mediators including interleukin-6 (IL-6) could induce AKR1C1/1C2 expression in NSCLC cells and increase cellular resistance to cisplatin and adriamycin. Doxorubicin 173-183 interleukin 6 Homo sapiens 67-71 17289797-4 2007 We found that treatment with the H2S donor, sodium hydrosulfide, led to significant increases in the mRNA expression and protein production of TNF-alpha, IL-1beta, and IL-6 in U937 cells. sodium bisulfide 44-63 interleukin 6 Homo sapiens 168-172 17321112-9 2007 Protein kinase C (PKC) activation by phorbol myristate acetate (PMA) potentiated IL-6 mRNA expression, whereas PKC inhibition by bisindolylmaleimide blocked SPC-induced p42/44 ERK phosphorylation and IL-6 expression. Tetradecanoylphorbol Acetate 37-62 interleukin 6 Homo sapiens 81-85 17321112-9 2007 Protein kinase C (PKC) activation by phorbol myristate acetate (PMA) potentiated IL-6 mRNA expression, whereas PKC inhibition by bisindolylmaleimide blocked SPC-induced p42/44 ERK phosphorylation and IL-6 expression. Tetradecanoylphorbol Acetate 64-67 interleukin 6 Homo sapiens 81-85 17306251-6 2007 We previously demonstrated that treatment of mast cells with heat shock or acetylsalicylic acid results in an increase of TNF-alpha and IL-6 release. Aspirin 75-95 interleukin 6 Homo sapiens 136-140 17341596-0 2007 Guanosine 3",5"-cyclic monophosphate (cGMP)/cGMP-dependent protein kinase induce interleukin-6 transcription in osteoblasts. Cyclic GMP 0-36 interleukin 6 Homo sapiens 81-94 17341596-0 2007 Guanosine 3",5"-cyclic monophosphate (cGMP)/cGMP-dependent protein kinase induce interleukin-6 transcription in osteoblasts. Cyclic GMP 38-42 interleukin 6 Homo sapiens 81-94 17341596-0 2007 Guanosine 3",5"-cyclic monophosphate (cGMP)/cGMP-dependent protein kinase induce interleukin-6 transcription in osteoblasts. Cyclic GMP 44-48 interleukin 6 Homo sapiens 81-94 17341596-3 2007 We found that C-type natriuretic peptide and the NO donor Deta-NONOate induced IL-6 mRNA expression in primary human osteoblasts, an effect mimicked by the membrane-permeable cGMP analog 8-chlorophenylthio-cGMP (8-CPT-cGMP). Cyclic GMP 175-179 interleukin 6 Homo sapiens 79-83 17341596-3 2007 We found that C-type natriuretic peptide and the NO donor Deta-NONOate induced IL-6 mRNA expression in primary human osteoblasts, an effect mimicked by the membrane-permeable cGMP analog 8-chlorophenylthio-cGMP (8-CPT-cGMP). Cyclic GMP 206-210 interleukin 6 Homo sapiens 79-83 17652834-9 2007 Additionally, we found that baseline IL-6 levels were higher in: smokers as compared with nonsmokers (p < 0.001), patients with total cholesterol (TC) to high density lipoprotein (HDL)-cholesterol ratio (TC/HDL-ch ratio) above 5 as compared with subjects with TC/HDL-ch < or = 5 (p = 0.001), and in patients who did not report any statin therapy in comparison with patients undergoing statin treatment (p = 0.023). Cholesterol 137-148 interleukin 6 Homo sapiens 37-41 17652834-9 2007 Additionally, we found that baseline IL-6 levels were higher in: smokers as compared with nonsmokers (p < 0.001), patients with total cholesterol (TC) to high density lipoprotein (HDL)-cholesterol ratio (TC/HDL-ch ratio) above 5 as compared with subjects with TC/HDL-ch < or = 5 (p = 0.001), and in patients who did not report any statin therapy in comparison with patients undergoing statin treatment (p = 0.023). Cholesterol 188-199 interleukin 6 Homo sapiens 37-41 17341596-4 2007 Similar results were obtained in rat UMR106 osteosarcoma cells, where C-type natriuretic peptide and 8-CPT-cGMP stimulated transcription of the human IL-6 promoter and increased IL-6 secretion into the medium. Cyclic GMP 107-111 interleukin 6 Homo sapiens 150-154 17341596-4 2007 Similar results were obtained in rat UMR106 osteosarcoma cells, where C-type natriuretic peptide and 8-CPT-cGMP stimulated transcription of the human IL-6 promoter and increased IL-6 secretion into the medium. Cyclic GMP 107-111 interleukin 6 Homo sapiens 178-182 17341596-5 2007 Cotransfection of type I PKG enhanced the cGMP effect on the IL-6 promoter, whereas small interfering RNA-mediated silencing of PKG I expression prevented the cGMP effect on IL-6 mRNA expression. Cyclic GMP 42-46 interleukin 6 Homo sapiens 61-65 17341596-5 2007 Cotransfection of type I PKG enhanced the cGMP effect on the IL-6 promoter, whereas small interfering RNA-mediated silencing of PKG I expression prevented the cGMP effect on IL-6 mRNA expression. Cyclic GMP 159-163 interleukin 6 Homo sapiens 174-178 17341596-6 2007 Step-wise deletion of the IL-6 promoter demonstrated a cAMP response element to be critical for transcriptional effects of cGMP, and experiments with dominant interfering proteins showed that cGMP activation of the promoter required cAMP response element binding-related proteins, and, to a lesser extent, proteins of the CAAT enhancer-binding protein and activator protein-1 (Fos/Jun) families. Cyclic AMP 55-59 interleukin 6 Homo sapiens 26-30 17341596-6 2007 Step-wise deletion of the IL-6 promoter demonstrated a cAMP response element to be critical for transcriptional effects of cGMP, and experiments with dominant interfering proteins showed that cGMP activation of the promoter required cAMP response element binding-related proteins, and, to a lesser extent, proteins of the CAAT enhancer-binding protein and activator protein-1 (Fos/Jun) families. Cyclic GMP 123-127 interleukin 6 Homo sapiens 26-30 17341596-6 2007 Step-wise deletion of the IL-6 promoter demonstrated a cAMP response element to be critical for transcriptional effects of cGMP, and experiments with dominant interfering proteins showed that cGMP activation of the promoter required cAMP response element binding-related proteins, and, to a lesser extent, proteins of the CAAT enhancer-binding protein and activator protein-1 (Fos/Jun) families. Cyclic GMP 192-196 interleukin 6 Homo sapiens 26-30 17341596-6 2007 Step-wise deletion of the IL-6 promoter demonstrated a cAMP response element to be critical for transcriptional effects of cGMP, and experiments with dominant interfering proteins showed that cGMP activation of the promoter required cAMP response element binding-related proteins, and, to a lesser extent, proteins of the CAAT enhancer-binding protein and activator protein-1 (Fos/Jun) families. Cyclic AMP 233-237 interleukin 6 Homo sapiens 26-30 17164077-6 2007 Serum estradiol concentration showed a significant negative correlation with serum IL-6 concentration and weak negative correlations with serum concentrations of IL-2, IL-8 and GM-CSF. Estradiol 6-15 interleukin 6 Homo sapiens 83-87 17164077-8 2007 We also found that serum IL-6 concentration during the menopausal transition was negatively correlated with serum estradiol concentration. Estradiol 114-123 interleukin 6 Homo sapiens 25-29 17404324-7 2007 PEG precipitates from Leishmania-infected patients induced significantly higher levels of GM-CSF (p = 0.0037) and IL-10 (p < 0.0001), as well as of IL-6 (p < 0.0001) and IL-1 receptor antagonist (p = 0.0238) as compared with PEG precipitates from controls. Polyethylene Glycols 0-3 interleukin 6 Homo sapiens 151-155 17439648-8 2007 Further, nanocurcumin"s mechanisms of action on pancreatic cancer cells mirror that of free curcumin, including induction of cellular apoptosis, blockade of nuclear factor kappa B (NFkappaB) activation, and downregulation of steady state levels of multiple pro-inflammatory cytokines (IL-6, IL-8, and TNFalpha). Curcumin 13-21 interleukin 6 Homo sapiens 285-289 17306835-0 2007 Capsaicin induces the production of IL-6 in human upper respiratory epithelial cells. Capsaicin 0-9 interleukin 6 Homo sapiens 36-40 17016430-6 2007 Additionally, ABT-737 abrogates MM cell growth triggered by interleukin-6 or insulin-like growth factor-1. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid 14-17 interleukin 6 Homo sapiens 60-73 17306835-4 2007 In order to clarify whether or not TRPV1 acts as a functional receptor, we examined the effects of capsaicin on the production of IL-6 from primary cultured human airway epithelial cells at both protein and mRNA levels. Capsaicin 99-108 interleukin 6 Homo sapiens 130-134 17306835-7 2007 Capsaicin (10 nM-10 muM) induced production of IL-6 from HNECs and NHBE cells and this effect was inhibited by pretreatment with capsazepine. Capsaicin 0-9 interleukin 6 Homo sapiens 47-51 17306835-8 2007 Our findings suggest that topical application of capsaicin to the airway induces IL-6 production from respiratory epithelial cells via activation of TRPV1. Capsaicin 49-58 interleukin 6 Homo sapiens 81-85 17204543-0 2007 Iron chelation acutely stimulates fetal human intestinal cell production of IL-6 and VEGF while decreasing HGF: the roles of p38, ERK, and JNK MAPK signaling. Iron 0-4 interleukin 6 Homo sapiens 76-80 17392554-7 2007 RESULTS: Serum IL-6 was an independent contributor to the variance of endothelium-dependent vasodilatation after adjusting for age, BMI, smoking status, LDL cholesterol, systolic blood pressure, diastolic blood pressure, and insulin sensitivity (P = 0.001). Cholesterol 157-168 interleukin 6 Homo sapiens 15-19 17416766-11 2007 IL6 genotype and haplotype significantly modified the association between aspirin and breast cancer, with the greatest effect modification being among women not recently exposed to hormones [P interaction = 0.06 (for non-Hispanic white) and 0.04 (for Hispanic/Native American) and SNP rs1800796 or -572G>C]. Aspirin 74-81 interleukin 6 Homo sapiens 0-3 17416766-12 2007 These data suggest that IL6 is associated with breast cancer risk and modifies the association between estrogen and aspirin and breast cancer risk. Aspirin 116-123 interleukin 6 Homo sapiens 24-27 17190908-9 2007 The addition of protein kinase (PKC or PKA) inhibitors or nitric oxide (NO) synthase inhibitors significantly reduced the RAGE and IL-6 mRNA expression and the RAGE protein expression. Nitric Oxide 58-70 interleukin 6 Homo sapiens 131-135 17511607-1 2007 The gene of human interleukin-6 (hIL-6) with an additional 20 amino acids on the N-end, including six histidine residues, was cloned into the expression plasmid pET28b(+). Histidine 102-111 interleukin 6 Homo sapiens 18-31 17511607-1 2007 The gene of human interleukin-6 (hIL-6) with an additional 20 amino acids on the N-end, including six histidine residues, was cloned into the expression plasmid pET28b(+). Histidine 102-111 interleukin 6 Homo sapiens 33-38 17374166-0 2007 The Interleukin-6 inflammation pathway from cholesterol to aging--role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases. Cholesterol 44-55 interleukin 6 Homo sapiens 4-17 17185492-8 2007 IL-6 is a cytokine that may have beneficial systemic effects by mobilizing glucose from the liver and free fatty acids from the adipose tissue and providing them to the strenuously working respiratory muscles. Glucose 75-82 interleukin 6 Homo sapiens 0-4 17267401-4 2007 Signaling through the MEK/MAPK pathway plays an important role as treatment with the MEK inhibitor PD98059 reduces the effects of insulin on IL-6 signaling. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 99-106 interleukin 6 Homo sapiens 141-145 16860297-7 2007 Exposure to the photochemically generated products of BD (primarily acrolein, acetaldehyde, formaldehyde, furan and ozone) induced significant increases in cytotoxicity, IL-8, and IL-6 gene expression compared to a synthetic mixture of primary products that was created by injecting the correct concentrations of the detected products from the irradiation experiments. Ozone 116-121 interleukin 6 Homo sapiens 180-184 16900358-3 2007 Supernatants of histamine-stimulated cells were evaluated for the production of IL-6 and IL-8 by ELISA, while the expression of ICAM-1 was evaluated by flow cytometry on IFN gamma-stimulated cells. Histamine 16-25 interleukin 6 Homo sapiens 80-84 17311330-6 2007 IL-6, MIP-1alpha, and G-CSF were negatively correlated with O2 saturation during RSV infection. Oxygen 60-62 interleukin 6 Homo sapiens 0-4 17374166-3 2007 Statins and Bisphosphonates inhibit Interleukin 6 mediated inflammation indirectly through regulation of endogenous cholesterol synthesis and isoprenoid depletion. Cholesterol 116-127 interleukin 6 Homo sapiens 36-49 17439741-0 2007 Elevation of tumor necrosis factor-alpha, interleukin-1beta and interleukin-6 levels in aortic intima of Chinese Guizhou minipigs with streptozotocin-induced diabetes. Streptozocin 135-149 interleukin 6 Homo sapiens 64-77 17164350-8 2007 Resveratrol inhibited both the constitutive and the interleukin 6-induced activation of STAT3. Resveratrol 0-11 interleukin 6 Homo sapiens 52-65 17320913-15 2007 Hence, our present findings indicate that chalcone suppresses both IL-6- and LPS-induced signaling pathways through the thiol-dependent intracellular redox state. Sulfhydryl Compounds 120-125 interleukin 6 Homo sapiens 67-71 17339489-8 2007 The same low H(2)O(2) concentration also induced the anti-inflammatory gene coding for heme oxygenase-1 (HO-1) and IL-6. Hydrogen Peroxide 13-21 interleukin 6 Homo sapiens 115-119 17094021-5 2007 DA-9601 dose-dependently decreased the gene expression and production of TNF-alpha, IL-1beta, and IL-6 on phorbol 12-myristate 13-acetate (PMA)- and calcium ionophore A23187-stimulated HMC-1 cells. Tetradecanoylphorbol Acetate 139-142 interleukin 6 Homo sapiens 98-102 17094021-5 2007 DA-9601 dose-dependently decreased the gene expression and production of TNF-alpha, IL-1beta, and IL-6 on phorbol 12-myristate 13-acetate (PMA)- and calcium ionophore A23187-stimulated HMC-1 cells. Calcium 149-156 interleukin 6 Homo sapiens 98-102 17094021-5 2007 DA-9601 dose-dependently decreased the gene expression and production of TNF-alpha, IL-1beta, and IL-6 on phorbol 12-myristate 13-acetate (PMA)- and calcium ionophore A23187-stimulated HMC-1 cells. Tetradecanoylphorbol Acetate 106-137 interleukin 6 Homo sapiens 98-102 17458594-15 2007 Administration of L-arginine and aprotinin led to suppression of the release of TNF-alpha, IL-1, and IL-6 during reperfusion in a statistically significant manner (all p < 0.05). Arginine 18-28 interleukin 6 Homo sapiens 101-105 17348820-5 2007 Beta-estradiol levels in women with primary infections showed significant negative correlations with cervical concentrations of IL-10, IL-1beta, and IL-6. Estradiol 0-14 interleukin 6 Homo sapiens 149-153 17064252-6 2007 CRP was strongly correlated, and TNF-alpha, IL-1beta and IL-6 were moderately correlated, with UBMA scores. ubma 95-99 interleukin 6 Homo sapiens 57-61 17273796-0 2007 Curcumin attenuates the expression of IL-1beta, IL-6, and TNF-alpha as well as cyclin E in TNF-alpha-treated HaCaT cells; NF-kappaB and MAPKs as potential upstream targets. Curcumin 0-8 interleukin 6 Homo sapiens 48-52 17273796-4 2007 However, it was unknown whether curcumin, showing inhibitory effects on NF-kappaB and MAPKs, attenuates the expression of TNF-alpha-induced IL-1beta, IL-6, IL-8, and TNF-alpha as well as cyclin E expression in HaCaT cells. Curcumin 32-40 interleukin 6 Homo sapiens 150-154 17273796-6 2007 We found that curcumin inhibited the expression of TNF-alpha-induced IL-1beta, IL-6, and TNF-alpha, but not IL-8, in TNF-alpha-treated HaCaT cells as well as the TNF-alpha-induced cyclin E expression. Curcumin 14-22 interleukin 6 Homo sapiens 79-83 17242212-0 2007 Interleukin-6 impairs the insulin signaling pathway, promoting production of nitric oxide in human umbilical vein endothelial cells. Nitric Oxide 77-89 interleukin 6 Homo sapiens 0-13 17208929-0 2007 The effects of oxygen concentration on in vitro output of prostaglandin E2 and interleukin-6 from human fetal membranes. Oxygen 15-21 interleukin 6 Homo sapiens 79-92 17242212-4 2007 We observed that IL-6 increased IRS-1 phosphorylation at Ser(312) and Ser(616); these effects were paralleled by increased Jun N-terminal protein kinase (JNK) and extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation and reversed by JNK and ERK1/2 inhibition. Serine 57-60 interleukin 6 Homo sapiens 17-21 17242212-4 2007 We observed that IL-6 increased IRS-1 phosphorylation at Ser(312) and Ser(616); these effects were paralleled by increased Jun N-terminal protein kinase (JNK) and extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation and reversed by JNK and ERK1/2 inhibition. Serine 70-73 interleukin 6 Homo sapiens 17-21 17242212-5 2007 In addition, IL-6 treatment resulted in impaired IRS-1 phosphorylation at Tyr(612), a site essential for engaging PI3-kinase. Tyrosine 74-77 interleukin 6 Homo sapiens 13-17 17242212-6 2007 Furthermore, IL-6 treatment reduced insulin-stimulated phosphorylation of eNOS at the stimulatory Ser(1177) site and impaired insulin-stimulated eNOS dephosphorylation at the inhibitory Thr(495) site. Serine 98-101 interleukin 6 Homo sapiens 13-17 17242212-6 2007 Furthermore, IL-6 treatment reduced insulin-stimulated phosphorylation of eNOS at the stimulatory Ser(1177) site and impaired insulin-stimulated eNOS dephosphorylation at the inhibitory Thr(495) site. Threonine 186-189 interleukin 6 Homo sapiens 13-17 16946718-0 2007 Extracellular ATP has stimulatory effects on the expression and release of IL-6 via purinergic receptors in normal human epidermal keratinocytes. Adenosine Triphosphate 14-17 interleukin 6 Homo sapiens 75-79 17224000-11 2007 Significant decreases in resistin, C-reactive protein, TNF-alpha, IL-6 and IL-18 were seen in the rosiglitazone-treated patients but not in the metformin-treated patients. Rosiglitazone 98-111 interleukin 6 Homo sapiens 66-70 16952201-2 2007 METHODS: To this end, we examined the relationship between plasma IL-6 concentration and different degrees of glucose homeostasis in a cohort of 470 Italian Caucasian subjects comprising 236 normal glucose tolerant (NGT), 49 IFG, 51 IGT, and 134 type 2 diabetic subjects. Glucose 110-117 interleukin 6 Homo sapiens 66-70 16952201-4 2007 Univariate correlations between IL-6 concentrations and metabolic variables in the whole cohort showed that IL-6 levels were positively correlated with age, BMI, waist, systolic and diastolic blood pressure, fasting plasma glucose, triglycerides, CRP, fibrinogen, and negatively correlated with insulin sensitivity, IGF-I and HDL. Glucose 223-230 interleukin 6 Homo sapiens 108-112 16952201-4 2007 Univariate correlations between IL-6 concentrations and metabolic variables in the whole cohort showed that IL-6 levels were positively correlated with age, BMI, waist, systolic and diastolic blood pressure, fasting plasma glucose, triglycerides, CRP, fibrinogen, and negatively correlated with insulin sensitivity, IGF-I and HDL. Triglycerides 232-245 interleukin 6 Homo sapiens 108-112 16952201-5 2007 In a subgroup analysis including NGT, IFG and IGT (n = 336), IL-6 levels were positively correlated with age, BMI, waist, systolic and diastolic blood pressure, triglycerides, CRP, fibrinogen, fasting insulin, 2 h post-load glucose, and negatively correlated with insulin sensitivity, IGF-I and HDL. Triglycerides 161-174 interleukin 6 Homo sapiens 61-65 16952201-5 2007 In a subgroup analysis including NGT, IFG and IGT (n = 336), IL-6 levels were positively correlated with age, BMI, waist, systolic and diastolic blood pressure, triglycerides, CRP, fibrinogen, fasting insulin, 2 h post-load glucose, and negatively correlated with insulin sensitivity, IGF-I and HDL. Glucose 224-231 interleukin 6 Homo sapiens 61-65 17178391-8 2007 Selective inhibitors of p38(mapk) (SB203580) or of MEK1/2, the direct upstream activator of ERK1/2 (PD98059), reduced the synthesis of IL-1beta, TNFalpha, IL-6 and IL-8 induced by either the chaperonins or LPS. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 100-107 interleukin 6 Homo sapiens 155-159 16946718-5 2007 SQ22563, an adenylate cyclase inhibitor, inhibited ATP-induced IL-6 release. Adenosine Triphosphate 51-54 interleukin 6 Homo sapiens 63-67 16946718-10 2007 These results suggest that cAMP-generating P2Y receptors are likely functional in ATP-induced IL-6 production in NHEKs. Cyclic AMP 27-31 interleukin 6 Homo sapiens 94-98 16946718-10 2007 These results suggest that cAMP-generating P2Y receptors are likely functional in ATP-induced IL-6 production in NHEKs. Adenosine Triphosphate 82-85 interleukin 6 Homo sapiens 94-98 17070997-5 2007 Both rofecoxib and ibuprofen treatment increased the gene expression of the pro-inflammatory mediators, IL6 and CCL2 (chemokine C-C motif ligand 2), following tissue injury compared to the placebo treatment. Ibuprofen 19-28 interleukin 6 Homo sapiens 104-107 17289483-10 2007 DEX significantly reduced at least 1 postoperative level of IL-6, IL-8, IL-10, CRP, and exhaled NO. Dexamethasone 0-3 interleukin 6 Homo sapiens 60-64 17079650-7 2007 Thimerosal exposure of DC led to the depletion of intracellular glutathione (GSH), and addition of exogenous GSH to DC abolished the TH2-promoting effect of thimerosal-treated DC, restoring secretion of TNF-alpha, IL-6, and IL-12p70 by DC and IFN-gamma secretion by T cells. Glutathione 109-112 interleukin 6 Homo sapiens 214-218 17062603-2 2007 Some of the macrophages appear to be enriched with free cholesterol (FCMphis), and we have shown that this process induces the synthesis and secretion of inflammatory cytokines, including TNF-alpha and IL-6. Cholesterol 56-67 interleukin 6 Homo sapiens 202-206 16946718-4 2007 The P2 antagonists, suramin-, reactive blue 2-, and periodate-oxidized ATP, inhibited ATP-induced IL-6 release, whereas pyridoxal-phosphate-6-azophenyl-2",4"-disulfonic acid, adenosine 3"-phosphate 5"-phosphate, 1-[N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, and pertussis toxin did not. Adenosine Triphosphate 71-74 interleukin 6 Homo sapiens 98-102 16946718-4 2007 The P2 antagonists, suramin-, reactive blue 2-, and periodate-oxidized ATP, inhibited ATP-induced IL-6 release, whereas pyridoxal-phosphate-6-azophenyl-2",4"-disulfonic acid, adenosine 3"-phosphate 5"-phosphate, 1-[N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, and pertussis toxin did not. Adenosine Triphosphate 86-89 interleukin 6 Homo sapiens 98-102 17173942-5 2007 In prostate cancer cells, signaling from epidermal growth factor receptor (EGFR) to the serine-threonine kinase Akt1, as well as from IL-6 to STAT3, have been demonstrated to be influenced by experimental interventions that target cholesterol homeostasis. Cholesterol 231-242 interleukin 6 Homo sapiens 134-138 17237426-4 2007 In the present study, we found that the fiber-modified Ad vector containing poly-lysine peptides in the fiber knob showed much lower serum IL-6 and aspartate aminotransferase levels (as a maker of liver toxicity) than the conventional Ad vector after i.v. Lysine 81-87 interleukin 6 Homo sapiens 139-143 17134824-12 2007 IL-6 was down-regulated in all three cell lines by all-trans-retinoic acid treatment. Tretinoin 61-74 interleukin 6 Homo sapiens 0-4 17445477-7 2007 The level of IL-6 secreted by CD(8)(+)CD(28)(-) T cells from tuberculosis group [(32.4 +/- 2.4)%] was significantly higher than bronchitis controls [(19.7 +/- 3.2)%] and healthy controls [(15.2 +/- 2.7)%] and no differences were found between bronchitis controls and healthy controls. Cadmium 30-32 interleukin 6 Homo sapiens 13-17 17445477-7 2007 The level of IL-6 secreted by CD(8)(+)CD(28)(-) T cells from tuberculosis group [(32.4 +/- 2.4)%] was significantly higher than bronchitis controls [(19.7 +/- 3.2)%] and healthy controls [(15.2 +/- 2.7)%] and no differences were found between bronchitis controls and healthy controls. Cadmium 38-40 interleukin 6 Homo sapiens 13-17 17113069-4 2007 Scopoletin significantly and dose-dependently inhibits the way in which phorbol 12-myristate 13-acetate (PMA) plus A23187 induces the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 (P<0.05). Scopoletin 0-10 interleukin 6 Homo sapiens 214-232 17113069-4 2007 Scopoletin significantly and dose-dependently inhibits the way in which phorbol 12-myristate 13-acetate (PMA) plus A23187 induces the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 (P<0.05). Tetradecanoylphorbol Acetate 72-103 interleukin 6 Homo sapiens 214-232 17113069-4 2007 Scopoletin significantly and dose-dependently inhibits the way in which phorbol 12-myristate 13-acetate (PMA) plus A23187 induces the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 (P<0.05). Tetradecanoylphorbol Acetate 105-108 interleukin 6 Homo sapiens 214-232 17113069-5 2007 The maximal rates at which scopoletin (0.2 mM) inhibited the production of TNF-alpha, IL-6, and IL-8 were 41.6%+/-4.2%, 71.9%+/-2.5%, and 43.0%+/-5.7%, respectively. Scopoletin 27-37 interleukin 6 Homo sapiens 86-90 17085445-7 2007 As shown by treatment with urea and binding competition experiments, the complex of IL-6 and IL-6-RFP is more stable than the complex of IL-6, soluble IL-6Ralpha, and soluble gp130. Urea 27-31 interleukin 6 Homo sapiens 84-88 17230612-12 2007 In decompensated patients sFas, IL-6 and NOx levels correlated positively with creatinine levels, while IL-6 levels were dependent on Child class. Creatinine 79-89 interleukin 6 Homo sapiens 32-36 17085445-7 2007 As shown by treatment with urea and binding competition experiments, the complex of IL-6 and IL-6-RFP is more stable than the complex of IL-6, soluble IL-6Ralpha, and soluble gp130. Urea 27-31 interleukin 6 Homo sapiens 93-97 17085445-7 2007 As shown by treatment with urea and binding competition experiments, the complex of IL-6 and IL-6-RFP is more stable than the complex of IL-6, soluble IL-6Ralpha, and soluble gp130. Urea 27-31 interleukin 6 Homo sapiens 93-97 17469457-1 2007 BACKGROUND: Prostaglandins modulate cytokine release though increases in cAMP, regulating interleukin-6 and interleukin-10. Cyclic AMP 73-77 interleukin 6 Homo sapiens 90-103 17569223-6 2007 Curcumin inhibits these autoimmune diseases by regulating inflammatory cytokines such as IL-1beta, IL-6, IL-12, TNF-alpha and IFN-gamma and associated JAK-STAT, AP-1, and NF-kappaB signaling pathways in immune cells. Curcumin 0-8 interleukin 6 Homo sapiens 99-103 17469457-1 2007 BACKGROUND: Prostaglandins modulate cytokine release though increases in cAMP, regulating interleukin-6 and interleukin-10. Prostaglandins 12-26 interleukin 6 Homo sapiens 90-103 17531096-0 2007 Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer. Tyrosine 9-17 interleukin 6 Homo sapiens 45-58 17284895-8 2007 Intraperitoneal IL-6 was the significant and positive determinant of the time course of the D/P creatinine ratio (p < 0.0001). Creatinine 96-106 interleukin 6 Homo sapiens 16-20 17317452-1 2007 IL-6 expression is regulated by the interplay of several transcriptional and hormonal factors, including sex steroids and glucocorticoids. Steroids 109-117 interleukin 6 Homo sapiens 0-4 17317452-2 2007 In late life IL-6 expression increases as a result from loss of the normally inhibiting sex steroids. Steroids 92-100 interleukin 6 Homo sapiens 13-17 17909718-8 2007 RESULTS: Postoperative plasma concentrations of IL-6 (days 1 and 2), IL-8 (days 2 and 3), and CRP (days 1-4) were significantly lower in the steroid than in the control group. Steroids 141-148 interleukin 6 Homo sapiens 48-52 17391979-3 2007 Forty eight hours after the exposure to ethanol (500 mM) significantly elevated the secretion of TNF-alpha, IL-6 and TGF-beta1 in the cell-free culture supernatant (HepG2 and mouse HCC cell lines), which were decreased on leptin (31.2 nM) treatment. Ethanol 40-47 interleukin 6 Homo sapiens 108-112 17849265-3 2007 Cyclic AMP elevating agents activate cathepsin B and stimulate the secretion of cathepsin B via the secretion of IL-6, a potent mediator of RA. Cyclic AMP 0-10 interleukin 6 Homo sapiens 113-117 17241887-1 2007 BACKGROUND & AIMS: Interleukin 6 (IL-6)-mediated signal transducers and activators of transcription 3 (STAT-3) phosphorylation (activation) is aberrantly sustained in cholangiocarcinoma cells resulting in enhanced myeloid cell leukemia 1 (Mcl-1) expression and resistance to apoptosis. Adenosine Monophosphate 12-15 interleukin 6 Homo sapiens 23-36 17241887-1 2007 BACKGROUND & AIMS: Interleukin 6 (IL-6)-mediated signal transducers and activators of transcription 3 (STAT-3) phosphorylation (activation) is aberrantly sustained in cholangiocarcinoma cells resulting in enhanced myeloid cell leukemia 1 (Mcl-1) expression and resistance to apoptosis. Adenosine Monophosphate 12-15 interleukin 6 Homo sapiens 38-42 17673806-7 2007 The likely mechanism of COX inhibition leading to Il-6 lowering is due to the tendency for Il-6 levels to be controlled by intracellular cyclic adenosine monophosphate (cAMP). Cyclic AMP 137-167 interleukin 6 Homo sapiens 50-54 17673806-7 2007 The likely mechanism of COX inhibition leading to Il-6 lowering is due to the tendency for Il-6 levels to be controlled by intracellular cyclic adenosine monophosphate (cAMP). Cyclic AMP 137-167 interleukin 6 Homo sapiens 91-95 17873309-9 2007 According to our results the inflammatory activity represented by high levels of IL-6 and CRP are involved in the pathogenesis of ACD, probably due to the action of inflammation on iron metabolism, but not in ARC. Iron 181-185 interleukin 6 Homo sapiens 81-85 17336462-6 2007 Previous studies showed that ghrelin has potent anti-inflammatory effect; inhibiting proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6). Ghrelin 29-36 interleukin 6 Homo sapiens 193-206 17336462-6 2007 Previous studies showed that ghrelin has potent anti-inflammatory effect; inhibiting proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6). Ghrelin 29-36 interleukin 6 Homo sapiens 208-212 17673806-7 2007 The likely mechanism of COX inhibition leading to Il-6 lowering is due to the tendency for Il-6 levels to be controlled by intracellular cyclic adenosine monophosphate (cAMP). Cyclic AMP 169-173 interleukin 6 Homo sapiens 50-54 17673806-7 2007 The likely mechanism of COX inhibition leading to Il-6 lowering is due to the tendency for Il-6 levels to be controlled by intracellular cyclic adenosine monophosphate (cAMP). Cyclic AMP 169-173 interleukin 6 Homo sapiens 91-95 17673806-12 2007 Lower cAMP results in lower Il-6 synthesis, lower levels of a required growth factor. Cyclic AMP 6-10 interleukin 6 Homo sapiens 28-32 17079162-4 2007 Fisetin decreased phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated gene expression and production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-4, IL-6, and IL-8 in HMC-1 cells. Tetradecanoylphorbol Acetate 18-49 interleukin 6 Homo sapiens 204-208 18336105-6 2007 Serum levels of interleukin-6 were statistically higher in the period with conventional bicarbonate dialysate (31.7+/- 24.7 vs. 18.7+/- 10.3 pg/ml, p=0.014), even though other inflammatory markers such as LBP, TNF- and CRP failed to increase in the same period. Bicarbonates 88-99 interleukin 6 Homo sapiens 16-29 18274638-3 2007 The aim of the present study is to investigate the ghrelin in congenital heart disease and the association of ghrelin with TNF-alpha and IL-6. Ghrelin 110-117 interleukin 6 Homo sapiens 137-141 17079162-4 2007 Fisetin decreased phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated gene expression and production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-4, IL-6, and IL-8 in HMC-1 cells. pmaci 81-86 interleukin 6 Homo sapiens 204-208 18333366-0 2007 IL-6 - STAT-3 - hepcidin: linking inflammation to the iron metabolism. Iron 54-58 interleukin 6 Homo sapiens 0-4 17420794-5 2007 In ischemic patients on carvedilol, levels of IL-6 and TNF-alpha dropped significantly (P= 0.028 and P=0.034, respectively). Carvedilol 24-34 interleukin 6 Homo sapiens 46-50 17420794-8 2007 In nonischemic patients on carvedilol, IL-6 and TNF-alpha levels dropped significantly (P=0.018 and P=0.004, respectively). Carvedilol 27-37 interleukin 6 Homo sapiens 39-43 17420794-11 2007 Carvedilol suppressed the plasma levels of TNF-alpha and IL-6 in both ischemic and nonischemic patients. Carvedilol 0-10 interleukin 6 Homo sapiens 57-61 17023731-8 2006 In vitro studies disclosed that the administration of ATRA reduced (1) irradiation-induced production of IL-6, TGF-beta(1), and collagen from IMR90 cells, and (2) IL-6-dependent proliferation and TGF-beta(1)-dependent transdifferentiation of the cells, which could be the mechanism underlying the preventive effect of ATRA on lung fibrosis. Tretinoin 54-58 interleukin 6 Homo sapiens 105-109 17023731-8 2006 In vitro studies disclosed that the administration of ATRA reduced (1) irradiation-induced production of IL-6, TGF-beta(1), and collagen from IMR90 cells, and (2) IL-6-dependent proliferation and TGF-beta(1)-dependent transdifferentiation of the cells, which could be the mechanism underlying the preventive effect of ATRA on lung fibrosis. Tretinoin 54-58 interleukin 6 Homo sapiens 163-167 17023731-8 2006 In vitro studies disclosed that the administration of ATRA reduced (1) irradiation-induced production of IL-6, TGF-beta(1), and collagen from IMR90 cells, and (2) IL-6-dependent proliferation and TGF-beta(1)-dependent transdifferentiation of the cells, which could be the mechanism underlying the preventive effect of ATRA on lung fibrosis. Tretinoin 318-322 interleukin 6 Homo sapiens 163-167 17036362-9 2006 As a biomarker of depression, IL-6 yielded at a cutoff value of 10.6 pg/mL, a sensitivity of 79%, and a specificity of 87% (area under the curve [AUC] = 0.86; 95% confidence interval [95% CI], 0.78-0.94), whereas cortisol VAR demonstrated a sensitivity of 81% and a specificity of 88% (AUC = 0.85; 95% CI, 0.74-0.97) at a cutoff value of 33.5%. Hydrocortisone 213-221 interleukin 6 Homo sapiens 30-34 17040902-2 2006 Hsps are known to be regulated by heat shock factor (Hsf), but our results demonstrate an unexpected regulatory link between the oxygen-sensing and heat shock pathways. Oxygen 129-135 interleukin 6 Homo sapiens 34-51 17040902-2 2006 Hsps are known to be regulated by heat shock factor (Hsf), but our results demonstrate an unexpected regulatory link between the oxygen-sensing and heat shock pathways. Oxygen 129-135 interleukin 6 Homo sapiens 53-56 17331441-7 2007 CONCLUSIONS: Aa-, Pg-, Ec-LPS may significantly increase IL-11 and IL-6 level in the supernatants of HGF, and endogenous prostaglandin may upregulate IL-11 and IL-6 production in LPS-stimulated HGF. Prostaglandins 121-134 interleukin 6 Homo sapiens 160-164 16857895-0 2006 High dexamethasone concentration prevents stimulatory effects of TNF-alpha and LPS on IL-6 secretion from the precursors of human muscle regeneration. Dexamethasone 5-18 interleukin 6 Homo sapiens 86-90 16857895-8 2006 Dex, applied at the 0.1-100 nM concentration range, prevented constitutive and TNF-alpha- and LPS-stimulated IL-6 release at both developmental stages but only at high concentration (P < 0.01). Dexamethasone 0-3 interleukin 6 Homo sapiens 109-113 16773437-4 2006 We hypothesized that patients whose tumors expressed higher amounts of IL-6 or PGP would be less likely to respond to paclitaxel, an agent affected by the PGP pathway. Paclitaxel 118-128 interleukin 6 Homo sapiens 71-75 16773437-5 2006 If so, then IL-6 could serve as a predictive factor for paclitaxel sensitivity. Paclitaxel 56-66 interleukin 6 Homo sapiens 12-16 17089010-0 2006 Comano"s (Trentino) thermal water interferes with interleukin-6 production and secretion and with cytokeratin-16 expression by cultured human psoriatic keratinocytes: further potential mechanisms of its anti-psoriatic action. Water 28-33 interleukin 6 Homo sapiens 50-63 17258468-8 2006 Inhibition of tyrosine/serine phosphorylation mediated by MAPKs of STAT1 and STAT3 decrease the IL-6 secretion following porin stimulation. Tyrosine 14-22 interleukin 6 Homo sapiens 96-100 17258468-8 2006 Inhibition of tyrosine/serine phosphorylation mediated by MAPKs of STAT1 and STAT3 decrease the IL-6 secretion following porin stimulation. Serine 23-29 interleukin 6 Homo sapiens 96-100 17374489-3 2006 This prospective study investigated the association between serum and urine IL-6 and IL-8 levels and acute pyelonephritis confirmed by (99m)Tc-dimercaptosuccinic acid (DMSA) scan. Technetium Tc 99m Dimercaptosuccinic Acid 168-172 interleukin 6 Homo sapiens 76-80 17035350-4 2006 Interestingly, our data suggest that TNF contributes, through lectin-saccharide interaction, to the secretion of IL-6 and NO induced by CCF. Carbohydrates 69-79 interleukin 6 Homo sapiens 113-117 17130674-4 2006 PD98059, a MEK (mitogen-activated protein kinase kinase) inhibitor, and BAPTA-AM [O,O"-bis(2-aminophenyl)ethyleneglycol-N,N,N",N"-tetraacetic acid, tetraacetoxymethyl ester], an intracellular Ca(2+) chelator, reduced UTP-induced ERK phosphorylation and IL-6 mRNA expression. o,o"-bis(2-aminophenyl)ethyleneglycol-n,n,n",n"-tetraacetic acid, tetraacetoxymethyl ester 82-172 interleukin 6 Homo sapiens 253-257 17119383-2 2006 Anemia of inflammation is caused by the effects of inflammatory cytokines [predominantly interleukin-6 (IL-6)] on iron transport in enterocytes and macrophages. Iron 114-118 interleukin 6 Homo sapiens 89-102 17119383-2 2006 Anemia of inflammation is caused by the effects of inflammatory cytokines [predominantly interleukin-6 (IL-6)] on iron transport in enterocytes and macrophages. Iron 114-118 interleukin 6 Homo sapiens 104-108 17119383-9 2006 Similarly, the difference between baseline and 2-hour serum iron level (Delta[Fe]2hr) correlated with IL-6 (P = 0.008) and CRP (P = 0.045). Iron 60-64 interleukin 6 Homo sapiens 102-106 17238830-6 2006 These molecularly defined N-glycosylated IL-24 dimers elicited dose-dependent secretion of tumor necrosis factor-alpha (TNF-alpha) and IL-6 from human monocytes, as well as cytotoxicity to human melanoma cell lines. Nitrogen 26-27 interleukin 6 Homo sapiens 135-139 18040816-5 2006 Suppression of IL-6, but not IL-12, production by EtOH was found to be mediated by corticosterone. Ethanol 50-54 interleukin 6 Homo sapiens 15-19 16884695-6 2006 Thus, activation of histamine H(1)-receptor-protein kinase C-mitogen-activated protein kinase signalling pathway plays a crucial role not only in the direct stimulation of NGF secretion by histamine, but also in the indirect stimulation via different types of interactions between histamine, interleukin-1beta, and interleukin-6, which may have important therapeutic implications in modulation of NGF production. Histamine 20-29 interleukin 6 Homo sapiens 315-328 16945991-0 2006 Signaling specificity of interleukin-6 action on glucose and lipid metabolism in skeletal muscle. Glucose 49-56 interleukin 6 Homo sapiens 25-38 16945991-4 2006 IL-6 increased glucose incorporation into glycogen, glucose uptake, lactate production, and fatty acid uptake and oxidation, concomitant with increased phosphorylation of AMP-activated protein kinase (AMPK), signal transducer and activator of transcription 3, and ERK1/2. Glucose 15-22 interleukin 6 Homo sapiens 0-4 16945991-4 2006 IL-6 increased glucose incorporation into glycogen, glucose uptake, lactate production, and fatty acid uptake and oxidation, concomitant with increased phosphorylation of AMP-activated protein kinase (AMPK), signal transducer and activator of transcription 3, and ERK1/2. Glucose 52-59 interleukin 6 Homo sapiens 0-4 16945991-4 2006 IL-6 increased glucose incorporation into glycogen, glucose uptake, lactate production, and fatty acid uptake and oxidation, concomitant with increased phosphorylation of AMP-activated protein kinase (AMPK), signal transducer and activator of transcription 3, and ERK1/2. Lactic Acid 68-75 interleukin 6 Homo sapiens 0-4 16945991-4 2006 IL-6 increased glucose incorporation into glycogen, glucose uptake, lactate production, and fatty acid uptake and oxidation, concomitant with increased phosphorylation of AMP-activated protein kinase (AMPK), signal transducer and activator of transcription 3, and ERK1/2. Fatty Acids 92-102 interleukin 6 Homo sapiens 0-4 16945991-6 2006 IL-6-mediated glucose metabolism was suppressed, but lipid metabolism was unaltered, by inhibition of PI3-kinase with LY294002. Glucose 14-21 interleukin 6 Homo sapiens 0-4 16945991-7 2006 The small interfering RNA-directed depletion of AMPK reduced IL-6-mediated fatty acid oxidation and palmitate uptake but did not reduce glycogen synthesis. Fatty Acids 75-85 interleukin 6 Homo sapiens 61-65 17082661-5 2006 Furthermore, atorvastatin reduced the production of IL-10 and IL-6 by T cells, implicated in the pathogenesis of SLE. Atorvastatin 13-25 interleukin 6 Homo sapiens 62-66 17723764-6 2006 Under optimal conditions, the current change obtained from the labeled HRP relative to thionine-H2O2 system was proportional to the IL-6 concentration in the range of 5-100 ng L(-1) with a detection limit of 1.0 ng L(-1) (at 3delta). Hydrogen Peroxide 96-100 interleukin 6 Homo sapiens 132-136 17049124-5 2006 RESULTS: The peptide has the ability to interact with the NF-kappaB p50 subunit and can effectively inhibit TNF-alpha and IL-6 production in the THP-1 cell line, PMA-induced ear edema and zymosan A-induced peritonitis in mice. Tetradecanoylphorbol Acetate 162-165 interleukin 6 Homo sapiens 122-126 17077523-6 2006 We showed that GJWGM inhibited the production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1alpha, IL-6, and IL-8 induced by LPS in dose dependent manner (p<0.05). gjwgm 15-20 interleukin 6 Homo sapiens 109-113 17261774-13 2006 However, since release of IL-6 is frequent in HCC, especially in its more advanced stages, the use of agents like curcumin or DHMEQ might be beneficial to counteract its adverse systemic effects (e.g., cachexia). Curcumin 114-122 interleukin 6 Homo sapiens 26-30 17197193-11 2006 AG490, SB203580, piceatannol, parthenolide and cycloheximide inhibit CT-1 induced IL-6 mRNA and protein expression whereas wortmannin and PD98059 did not inhibit IL-6 expression. parthenolide 30-42 interleukin 6 Homo sapiens 82-86 17002607-8 2006 After 50 mg or 100 mg HE2000, but not after placebo, there were significant sustained decreases in IL-1beta, TNF-alpha, IL-6 and Cox-2 transcripts (p < 0.05). 16alpha-bromo-3beta-hydroxy-5alpha-androstan-17-one 22-28 interleukin 6 Homo sapiens 120-124 16647242-9 2006 During exercise, with and without carbohydrate ingestion, plasma IL-6 increased 8- and 18-fold, respectively, and HSP72 increased 5-fold (P<.05). Carbohydrates 34-46 interleukin 6 Homo sapiens 65-69 17197194-7 2006 IL-6 mRNA increased time- and dose-dependently with ionomycin stimulation, an effect that was blunted by approximately 75% in the presence of CSA. Ionomycin 52-61 interleukin 6 Homo sapiens 0-4 17197194-10 2006 Blocking the calcineurin pathway resulted in inhibition of the IL-6 response to ionomycin, whereas TNF-alpha increased by addition of CSA, further indicating a differential regulation of IL-6 and TNF-alpha in human skeletal myocytes. Ionomycin 80-89 interleukin 6 Homo sapiens 63-67 17122970-1 2006 OBJECTIVE AND DESIGN: In this ex vivo laboratory study, we investigated the effects of E5564 (eritoran), a toll-like receptor 4-directed endotoxin antagonist, on intracellular expression of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha in lipopolysaccharide (LPS)-stimulated human monocytes assessed by flow cytometry. eritoran 94-102 interleukin 6 Homo sapiens 190-208 16924534-0 2006 Prostaglandin D2 and J2-series (PGJ2, Delta12-PGJ2) prostaglandins stimulate IL-6 and MCP-1, but inhibit leptin, expression and secretion by 3T3-L1 adipocytes. Prostaglandins 52-66 interleukin 6 Homo sapiens 77-81 17135599-2 2006 The objective of this study was to investigate potential associations between the promoter polymorphism IL-6 -174G/C and the following indices of metabolism: BMI, waist-to-hip ratio, and plasma levels of IL-6, cholesterol, low-density lipoprotein, triglycerides, high-density lipoprotein, leptin, and C-reactive protein in 252 42-year-old women and 245 51-year-old men. Triglycerides 248-261 interleukin 6 Homo sapiens 104-108 17135599-4 2006 The CC genotype of the IL-6 polymorphism was associated with lower levels of cholesterol and low-density lipoprotein (p < 0.001) in women. Cholesterol 77-88 interleukin 6 Homo sapiens 23-27 16890260-8 2006 Furthermore, AEMD attenuated the phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-alpha, IL-8 and IL-6 secretion in human mast cells. Tetradecanoylphorbol Acetate 33-64 interleukin 6 Homo sapiens 131-135 16890260-8 2006 Furthermore, AEMD attenuated the phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-alpha, IL-8 and IL-6 secretion in human mast cells. Calcium 75-82 interleukin 6 Homo sapiens 131-135 16926159-3 2006 Here we show that treatment of cultured HepG2 hepatoma cells with PDTC inhibits IL-6-stimulated tyrosine phosphorylation and subsequent nuclear translocation of STAT3 in a dose- and time-dependent fashion. Tyrosine 96-104 interleukin 6 Homo sapiens 80-84 17000234-1 2006 OBJECTIVE: The purpose of this study was to characterize effect of progesterone (P4) on interleukin-6 (IL-6) production by fetoplacental artery explants, fetal granulocytes, and fetal and maternal mononuclear cells. Progesterone 67-79 interleukin 6 Homo sapiens 88-101 16875647-12 2006 Median cord blood interleukin-6 levels were reduced with the high-dose steroid treatment, but this result was statistically significant only between the high-dose and placebo groups (24.0 +/- 38.5 vs 32.0 +/- 95.0 pg/mL, respectively; P = .02). Steroids 71-78 interleukin 6 Homo sapiens 18-31 16876827-5 2006 PEDF suppressed the intracellular reactive oxygen species generation in IL-6-exposed Hep3B cells. Reactive Oxygen Species 34-57 interleukin 6 Homo sapiens 72-76 17000234-0 2006 Progesterone reduces lipopolysaccharide induced interleukin-6 secretion in fetoplacental chorionic arteries, fractionated cord blood, and maternal mononuclear cells. Progesterone 0-12 interleukin 6 Homo sapiens 48-61 17000234-1 2006 OBJECTIVE: The purpose of this study was to characterize effect of progesterone (P4) on interleukin-6 (IL-6) production by fetoplacental artery explants, fetal granulocytes, and fetal and maternal mononuclear cells. Progesterone 67-79 interleukin 6 Homo sapiens 103-107 17003332-0 2006 Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Glucose 43-50 interleukin 6 Homo sapiens 0-13 16973825-9 2006 In TNF-alpha-treated HCAECs, resveratrol (in the submicromolar range) significantly attenuated expression of NF-kappaB-dependent inflammatory markers inducible nitric oxide synthase, IL-6, bone morphogenetic protein-2, ICAM-1, and VCAM. Resveratrol 29-40 interleukin 6 Homo sapiens 183-187 16793131-9 2006 Finally, we observed that primary macrophages released higher amounts of TNF-alpha, IL-6 and IL-1beta after incubation with titanium particles than with rutile. Titanium 124-132 interleukin 6 Homo sapiens 84-88 16806458-3 2006 Results indicate that a number of the primary carbon/resin materials demonstrate efficient adsorption of the cytokines studied here (TNF, IL-6 and IL-8), comparable to other adsorbents under clinical investigation. Carbon 46-52 interleukin 6 Homo sapiens 138-142 17003332-2 2006 Here, we show that IL-6 infusion increases glucose disposal without affecting the complete suppression of endogenous glucose production during a hyperinsulinemic-euglycemic clamp in healthy humans. Glucose 43-50 interleukin 6 Homo sapiens 19-23 17003332-4 2006 IL-6 treatment increased fatty acid oxidation, basal and insulin-stimulated glucose uptake, and translocation of GLUT4 to the plasma membrane. Fatty Acids 25-35 interleukin 6 Homo sapiens 0-4 16632518-9 2006 ATP and ATPgammaS increased SAEC IL-6 secretion in a time- and dose-dependent manner, an effect inhibited by apyrase. Adenosine Triphosphate 0-3 interleukin 6 Homo sapiens 33-37 17161616-11 2006 Several pro-inflammatory/resorptive cytokines including IL-6, IL-4, IFN-gamma, macrophage inhibitory factor (MIF) were down-regulated not only by DEX but also by DHEA. Dexamethasone 146-149 interleukin 6 Homo sapiens 56-60 16896935-11 2006 CONCLUSIONS/INTERPRETATION: Homocysteine upregulates the MMP-TIMP pathway and IL6 release, the effect being stronger in the presence of high glucose. Glucose 141-148 interleukin 6 Homo sapiens 78-81 17003332-4 2006 IL-6 treatment increased fatty acid oxidation, basal and insulin-stimulated glucose uptake, and translocation of GLUT4 to the plasma membrane. Glucose 76-83 interleukin 6 Homo sapiens 0-4 17003332-0 2006 Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Fatty Acids 93-103 interleukin 6 Homo sapiens 0-13 17003332-8 2006 Our results demonstrate that acute IL-6 treatment enhances insulin-stimulated glucose disposal in humans in vivo, while the effects of IL-6 on glucose and fatty acid metabolism in vitro appear to be mediated by AMPK. Glucose 78-85 interleukin 6 Homo sapiens 35-39 16642480-0 2006 Targeting constitutive and interleukin-6-inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma cells by curcumin (diferuloylmethane). Curcumin 162-170 interleukin 6 Homo sapiens 27-40 17003332-8 2006 Our results demonstrate that acute IL-6 treatment enhances insulin-stimulated glucose disposal in humans in vivo, while the effects of IL-6 on glucose and fatty acid metabolism in vitro appear to be mediated by AMPK. Glucose 143-150 interleukin 6 Homo sapiens 135-139 17003332-8 2006 Our results demonstrate that acute IL-6 treatment enhances insulin-stimulated glucose disposal in humans in vivo, while the effects of IL-6 on glucose and fatty acid metabolism in vitro appear to be mediated by AMPK. Fatty Acids 155-165 interleukin 6 Homo sapiens 135-139 16574371-4 2006 FPT dose dependently decreased the gene expression and production of TNF-alpha and IL-6 on phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated HMC-1 cells. Tetradecanoylphorbol Acetate 91-122 interleukin 6 Homo sapiens 83-87 16574371-4 2006 FPT dose dependently decreased the gene expression and production of TNF-alpha and IL-6 on phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated HMC-1 cells. Tetradecanoylphorbol Acetate 124-127 interleukin 6 Homo sapiens 83-87 16574371-4 2006 FPT dose dependently decreased the gene expression and production of TNF-alpha and IL-6 on phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated HMC-1 cells. Calcium 133-140 interleukin 6 Homo sapiens 83-87 16896785-1 2006 OBJECTIVE: The objective of this study was to assess the effect of amlodipine-atorvastatin combination on plasma interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and insulin sensitivity in normocholesterolemic obese hypertensive patients. Atorvastatin 78-90 interleukin 6 Homo sapiens 113-126 16896785-1 2006 OBJECTIVE: The objective of this study was to assess the effect of amlodipine-atorvastatin combination on plasma interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and insulin sensitivity in normocholesterolemic obese hypertensive patients. Atorvastatin 78-90 interleukin 6 Homo sapiens 128-132 16984619-6 2006 Clinically, pegylated-liposomal doxorubicin induced regression of not only KS, but also lymphadenopathy of the MCD lesion with a decrease in KSHV load and human interleukin-6 in the blood. Doxorubicin 32-43 interleukin 6 Homo sapiens 161-174 16642480-0 2006 Targeting constitutive and interleukin-6-inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma cells by curcumin (diferuloylmethane). Curcumin 172-189 interleukin 6 Homo sapiens 27-40 16642480-7 2006 Besides inhibiting constitutive expression, curcumin also abrogated the IL-6-induced activation of STAT3 in HNSCC cells. Curcumin 44-52 interleukin 6 Homo sapiens 72-76 16642480-10 2006 Overall, our results demonstrated that curcumin is a potent inhibitor of constitutive and IL-6-induced STAT3 phosphorylation. Curcumin 39-47 interleukin 6 Homo sapiens 90-94 17699316-10 2006 Serum IL-6 concentration decreased with aspirin treatment but not significantly (P = 0.1). Aspirin 40-47 interleukin 6 Homo sapiens 6-10 17111070-10 2006 In an assay for inhibition of the H(2)O(2)-activated release of PGE2, IL-6, and IL-8 in normal human fibroblast cell lines, Ulmus davidiana root extract showed an inhibitory activity of PGE2 release in a dose-dependent manner (up to 85.9% at a concentration of 0.1%). Hydrogen Peroxide 34-42 interleukin 6 Homo sapiens 70-74 17375405-3 2006 Glucose, glucose metabolites and AGEs alter endothelial cell functions, induce adhesion molecule overexpression (ICAM-1, VCAM), cytokine release (IL-6, MCP-1) and tissue factor production. Glucose 0-7 interleukin 6 Homo sapiens 146-150 16914597-7 2006 Serum IL-6 levels correlated significantly (P < 0.05) with testosterone and estradiol levels (r=-0.37 and -0.42 respectively), whereas estradiol, but not testosterone, correlated with leptin/receptor ratio (r=0.59; P < 0.001). Testosterone 62-74 interleukin 6 Homo sapiens 6-10 16914597-7 2006 Serum IL-6 levels correlated significantly (P < 0.05) with testosterone and estradiol levels (r=-0.37 and -0.42 respectively), whereas estradiol, but not testosterone, correlated with leptin/receptor ratio (r=0.59; P < 0.001). Estradiol 79-88 interleukin 6 Homo sapiens 6-10 17122961-0 2006 Histamine induces interleukin-6 expression in the human synovial sarcoma cell line (SW982) through the H1 receptor. Histamine 0-9 interleukin 6 Homo sapiens 18-31 17122961-5 2006 Histamine (EC50 = 1.8 +/- 1.1 microM) stimulated the release of IL-6 that was attenuated by selective H1 antagonists. Histamine 0-9 interleukin 6 Homo sapiens 64-68 17122961-6 2006 The PKC inhibitor, GF1090203X, blocked the histamine stimulated IL-6 release. Histamine 43-52 interleukin 6 Homo sapiens 64-68 17122961-8 2006 CONCLUSION: We conclude that histamine stimulates IL-6 release from SW982 cells by binding to the H1 receptor and this is coupled to the PI/PKC signal transduction pathway. Histamine 29-38 interleukin 6 Homo sapiens 50-54 16936090-6 2006 Triptolide and dexamethasone each inhibited in a concentration-dependent manner the LPS-induced release of IL-6, G-CSF, MCP-1, and IL-8 by corneal fibroblasts. Dexamethasone 15-28 interleukin 6 Homo sapiens 107-111 16936090-7 2006 Whereas the inhibitory effect of dexamethasone on LPS-induced IL-6 release was greater than that of triptolide, the inhibitory effect of triptolide on LPS-induced G-CSF release was more pronounced than was that of dexamethasone. Dexamethasone 33-46 interleukin 6 Homo sapiens 62-66 16954997-13 2006 Interleukin (IL)-6 stimulated DTDST activity in normal stapes, whereas Dex inhibited IL-6 production only in otosclerotic stapes. Dexamethasone 71-74 interleukin 6 Homo sapiens 85-89 16954997-14 2006 CONCLUSION: Dex inhibits the DTDST activity, at least in part, through a reduction of IL-6 secretion only in otosclerotic cells. Dexamethasone 12-15 interleukin 6 Homo sapiens 86-90 16954997-3 2006 Because glucocorticoids modulate the bone turnover and inhibit inflammatory processes, we investigated the effect of dexamethasone (Dex) on interleukin-6 and DTDST in otosclerosis. Dexamethasone 117-130 interleukin 6 Homo sapiens 140-153 16919544-10 2006 In conclusion, this study shows that in Asian Indians, inflammatory markers (CRP, IL-6, and VCAM-1) increase with increasing degrees of glucose intolerance. Glucose 136-143 interleukin 6 Homo sapiens 82-86 16954997-3 2006 Because glucocorticoids modulate the bone turnover and inhibit inflammatory processes, we investigated the effect of dexamethasone (Dex) on interleukin-6 and DTDST in otosclerosis. Dexamethasone 132-135 interleukin 6 Homo sapiens 140-153 16894332-0 2006 Effects of intranasal 17beta-estradiol administration on serum bioactive interleukin-6 and C-reactive protein levels in healthy postmenopausal women. Estradiol 22-38 interleukin 6 Homo sapiens 73-86 16894332-2 2006 The aim of our study was to investigate the effects of intranasal 17beta-estradiol (E2) on serum CRP and its most potent stimulant, interleukin-6 in healthy postmenopausal women. Estradiol 66-82 interleukin 6 Homo sapiens 132-145 16894332-2 2006 The aim of our study was to investigate the effects of intranasal 17beta-estradiol (E2) on serum CRP and its most potent stimulant, interleukin-6 in healthy postmenopausal women. Estradiol 84-86 interleukin 6 Homo sapiens 132-145 18079991-7 2006 Increases of tryptophan and 5-HT, but not NE, are also elicited by IL-6, which also activates the HPA axis, although it is much less potent in these respects than IL-1. Tryptophan 13-23 interleukin 6 Homo sapiens 67-71 16894332-8 2006 Conversely, serum median bioactive interleukin-6 levels were significantly lower after 6 and 12 months in women taking E2 intranasally or orally and after 12 months in women taking E2 transdermally (P < 0.05). Estradiol 119-121 interleukin 6 Homo sapiens 35-48 16547493-0 2006 Paclitaxel (Taxol) upregulates expression of functional interleukin-6 in human ovarian cancer cells through multiple signaling pathways. Paclitaxel 0-10 interleukin 6 Homo sapiens 56-69 16547493-0 2006 Paclitaxel (Taxol) upregulates expression of functional interleukin-6 in human ovarian cancer cells through multiple signaling pathways. Paclitaxel 12-17 interleukin 6 Homo sapiens 56-69 16547493-4 2006 Among 20 genes that were specifically regulated by the paclitaxel-activated JNK pathway, interleukin (IL)-6 was shown to elicit function through the JAK-STAT signaling pathway in an autocrine and/or paracrine fashion. Paclitaxel 55-65 interleukin 6 Homo sapiens 89-107 16547493-5 2006 Subsequently, we identified that 87.5% of eight tested ovarian cancer lines secreted detectable levels of IL-6, which could be further upregulated 2-3.2 fold by 1 microM paclitaxel. Paclitaxel 170-180 interleukin 6 Homo sapiens 106-110 16547493-6 2006 Dissection on regulatory pathways for IL-6 indicated that (i) when ovarian cancer cells were treated with paclitaxel at low but clinically achievable concentrations (exemplified by 1 microM in this study), the JNK signaling pathway was the major stimulator of IL-6 gene regulation and (ii) at suprapharmacologically high concentrations (exemplified by 50 microM), paclitaxel exerted lipopolysaccharide-like effects, most likely through the Toll-like receptor 4 signaling pathway. Paclitaxel 106-116 interleukin 6 Homo sapiens 38-42 16547493-6 2006 Dissection on regulatory pathways for IL-6 indicated that (i) when ovarian cancer cells were treated with paclitaxel at low but clinically achievable concentrations (exemplified by 1 microM in this study), the JNK signaling pathway was the major stimulator of IL-6 gene regulation and (ii) at suprapharmacologically high concentrations (exemplified by 50 microM), paclitaxel exerted lipopolysaccharide-like effects, most likely through the Toll-like receptor 4 signaling pathway. Paclitaxel 106-116 interleukin 6 Homo sapiens 260-264 16547493-6 2006 Dissection on regulatory pathways for IL-6 indicated that (i) when ovarian cancer cells were treated with paclitaxel at low but clinically achievable concentrations (exemplified by 1 microM in this study), the JNK signaling pathway was the major stimulator of IL-6 gene regulation and (ii) at suprapharmacologically high concentrations (exemplified by 50 microM), paclitaxel exerted lipopolysaccharide-like effects, most likely through the Toll-like receptor 4 signaling pathway. Paclitaxel 364-374 interleukin 6 Homo sapiens 38-42 16547493-7 2006 Collectively, these results suggest that paclitaxel upregulates functional IL-6 expression in human ovarian cancer cells through multiple signaling pathways. Paclitaxel 41-51 interleukin 6 Homo sapiens 75-79 16284083-12 2006 Future studies should investigate 17beta-estradiol effects on IL-6 production and neutrophil infiltration within skeletal muscle during and after exercise. Estradiol 34-50 interleukin 6 Homo sapiens 62-66 16793032-6 2006 CONCLUSION: The IHD patients with low serum iron were associated with a pro-inflammatory state, such as increased TNF-alpha, IL-6, and hsCRP; increased anti-inflammatory activities, such as increased IL-10; decreased cardiac protective factor, such as decreased IGF-I. Iron 44-48 interleukin 6 Homo sapiens 125-129 16930264-5 2006 In addition, testosterone levels were inversely correlated with IL-6 and TNF-alpha. Testosterone 13-25 interleukin 6 Homo sapiens 64-68 16887032-13 2006 However, later stage pathological consequences of Abeta treatment associated with inflammation and cell degeneration including increased levels of IL-6, activation of MMP-2, and loss of HCSM alpha actin were significantly diminished by dexamethasone but not by indomethacin or ibuprofen. Dexamethasone 236-249 interleukin 6 Homo sapiens 147-151 16911361-7 2006 RESULTS: Real-time PCR revealed that poly I : C significantly increased the expression of mRNAs for chemokines IP-10, RANTES, LARC, MIP-1alpha, IL-8, GRO-alpha and ENA-78 and cytokines IL-1beta, GM-CSF, IL-6 and the cell adhesion molecule ICAM-1 in both cell types. Poly I 37-43 interleukin 6 Homo sapiens 203-207 21158076-0 2006 [Interleukin-6 prevents cultured cerebellar granule neurons from glutamate-induced neurotoxicity]. Glutamic Acid 65-74 interleukin 6 Homo sapiens 1-14 16842597-9 2006 Moreover, TA-inhibited UVB enhanced the expression of the inflammatory mediators, IL-1, IL-6, tumor necrotic factor-alpha, cyclooxygenase-2 and prostaglandin E(2) in UVB-irradiated HaCaT cells. Tannins 10-12 interleukin 6 Homo sapiens 88-121 16896803-6 2006 In HCAEC exposed to TNF-alpha, IVIG and dexamethasone inhibited interleukin-6 production to a similar degree, whereas the expression of E-selectin was inhibited more strongly by IVIG. Dexamethasone 40-53 interleukin 6 Homo sapiens 64-77 17175644-6 2006 But there was significant difference in these indices between control and SP group (the proliferative activity of KSF, HSF, NDF was 0. TFF2 protein, human 74-76 interleukin 6 Homo sapiens 119-122 17175644-14 2006 SP had stronger effect on KSF than it did to HSF, as well as it had stronger effect on HSF than it did to NDF. TFF2 protein, human 0-2 interleukin 6 Homo sapiens 45-48 17175644-14 2006 SP had stronger effect on KSF than it did to HSF, as well as it had stronger effect on HSF than it did to NDF. TFF2 protein, human 0-2 interleukin 6 Homo sapiens 87-90 17175644-15 2006 In SP + spantide group, the effect of SP on KSF was partially inhibited, while it was completely inhibited in cultures of HSF and NDF. TFF2 protein, human 3-5 interleukin 6 Homo sapiens 122-125 16873800-5 2006 Odds of elevated IL-6 and TNF-alpha (>75th percentile) were, respectively, 1.95 (95% CI 1.56-2.44) and 1.88 (1.51-2.35) for diabetic participants and 1.51 (1.21-1.87) and 1.14 (0.92-1.42) for those with IFG/IGT after adjustment for age, sex, race, smoking, alcohol intake, education, and study site. Alcohols 260-267 interleukin 6 Homo sapiens 17-21 16884979-14 2006 CONCLUSION: Sevoflurane suppressed the production of IL-6 and IL-8, but not IL-10 and IL-1ra. Sevoflurane 12-23 interleukin 6 Homo sapiens 53-57 21158076-1 2006 AIM: To explore IL-6 neuroprotection against glutamate-induced neurotoxicity and primary mechanisms involved in this neuroprotection. Glutamic Acid 45-54 interleukin 6 Homo sapiens 16-20 21158076-5 2006 RESULTS: The chronic IL-6 (2.5, 5 and 10 ng/ml) pretreatment of the cultured cerebellar granule neurons remarkably improved the decreased neuronal vitality by glutamate in a concentration-dependent manner. Glutamic Acid 159-168 interleukin 6 Homo sapiens 21-25 21158076-6 2006 The neuronal apoptosis induced by glutamate was significantly attenuated by the chronic IL-6 pretreatment. Glutamic Acid 34-43 interleukin 6 Homo sapiens 88-92 21158076-7 2006 The intracellular Ca2+ overload evoked by glutamate was also inhibited by the chronic IL-6 pretreatment. Glutamic Acid 42-51 interleukin 6 Homo sapiens 86-90 21158076-9 2006 CONCLUSION: IL-6 can protect neurons against glutamate-induced exciting neurotoxicity. Glutamic Acid 45-54 interleukin 6 Homo sapiens 12-16 21158076-10 2006 The mechanism of IL-6 neuroprotection may be closely related to the suppression of glutamate-induced intracellular Ca2+ overload and mediated by gp130 intracellular signal transduction pathways. Glutamic Acid 83-92 interleukin 6 Homo sapiens 17-21 16714289-7 2006 PGE(2)-stimulated [phospho-Ser(15)]p53 transactivated a p53 response element (GADD45)-luciferase reporter in transiently transfected HSF (SN7); the effect was compromised by overexpression of a dominant-negative mutant (dnm) of p53 or excess p53S15A expression plasmid but mimicked by a constitutively active p53S15E expression construct. Serine 27-30 interleukin 6 Homo sapiens 133-136 16714289-3 2006 We examined the regulation of the tumor suppressor gene p53 and p53 target genes by prostaglandin E(2) (PGE(2)) in human synovial fibroblasts (HSF). Dinoprostone 84-102 interleukin 6 Homo sapiens 143-146 16818790-9 2006 In addition, we showed that Zn was essential for plasma membrane translocation of protein kinase C and subsequent nuclear translocation of NF-kappaB, leading to cytokine production, such as IL-6 and TNF-alpha. Zinc 28-30 interleukin 6 Homo sapiens 190-194 16714289-3 2006 We examined the regulation of the tumor suppressor gene p53 and p53 target genes by prostaglandin E(2) (PGE(2)) in human synovial fibroblasts (HSF). Dinoprostone 104-110 interleukin 6 Homo sapiens 143-146 16714289-7 2006 PGE(2)-stimulated [phospho-Ser(15)]p53 transactivated a p53 response element (GADD45)-luciferase reporter in transiently transfected HSF (SN7); the effect was compromised by overexpression of a dominant-negative mutant (dnm) of p53 or excess p53S15A expression plasmid but mimicked by a constitutively active p53S15E expression construct. Dinoprostone 0-6 interleukin 6 Homo sapiens 133-136 16614347-6 2006 LPS-induced release of 10 cytokines was less suppressed by dexamethasone (10(-6) M) in patients with severe asthma compared with patients with nonsevere asthma, with statistical significance achieved for IL-1beta (p < 0.03), IL-8 (p < 0.03), and MIP-1alpha (p < 0.003), and borderline significance for IL-6 (p = 0.054). Dexamethasone 59-72 interleukin 6 Homo sapiens 311-315 16464907-1 2006 Inflammation is associated with insulin resistance, and both tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 may affect glucose uptake. Glucose 129-136 interleukin 6 Homo sapiens 99-117 16566946-6 2006 Sinomenine could significantly inhibit proliferation of IL-1 beta-activated Hs701.T cells and suppress expression of 17 genes including IL-6, PlGF, Daxx, and HSP27. sinomenine 0-10 interleukin 6 Homo sapiens 136-140 16790652-8 2006 Plasma levels of interleukin-6 and soluble adhesion molecules were significantly (P < 0.05) higher in the HA- than in the HES-treated patients. Hydroxyethyl Starch Derivatives 125-128 interleukin 6 Homo sapiens 17-30 16716291-0 2006 ATP stimulates interleukin-6 production via P2Y receptors in human HaCaT keratinocytes. Adenosine Triphosphate 0-3 interleukin 6 Homo sapiens 15-28 17077666-7 2006 In contrast, Dex treatment inhibited the IL-1beta-induced production of GM-CSF, IL-6, IL-8, MCP-3, and RANTES, but not MCP-1. Dexamethasone 13-16 interleukin 6 Homo sapiens 80-84 16804071-3 2006 Fasting plasma IL-6 concentration was negatively correlated with the rate of insulin-stimulated glucose disposal (M) (P = 0.001). Glucose 96-103 interleukin 6 Homo sapiens 15-19 16439466-1 2006 Platelet-activating factor (PAF) and interleukin-6 (IL-6) are produced in the esophagus in response to HCl and affect ACh release, causing changes in esophageal motor function similar to esophagitis (Cheng L, Cao W, Fiocchi C, Behar J, Biancani P, and Harnett KM. Hydrochloric Acid 103-106 interleukin 6 Homo sapiens 37-50 16830075-6 2006 A negative correlation (p < 0.01) between IL-6, IL-8, and mixed venous oxygen saturation suggested compromised cardiopulmonary function. Oxygen 74-80 interleukin 6 Homo sapiens 45-49 17074112-13 2006 In the calcium preparation group and control group, the levels of BMD, E(2), ALP, BGP and insulin-like growth factor I decreased (P < 0.05), while those of IL-6, TNFalpha and NTX increased (P < 0.05). Calcium 7-14 interleukin 6 Homo sapiens 159-163 16800873-6 2006 In contrast, secretion of TNF-alpha and IL-6 decreased significantly following both cholesterol and triglyceride loading, with a similar trend for secretion of IL-8. Cholesterol 84-95 interleukin 6 Homo sapiens 40-44 16800873-6 2006 In contrast, secretion of TNF-alpha and IL-6 decreased significantly following both cholesterol and triglyceride loading, with a similar trend for secretion of IL-8. Triglycerides 100-112 interleukin 6 Homo sapiens 40-44 16439466-1 2006 Platelet-activating factor (PAF) and interleukin-6 (IL-6) are produced in the esophagus in response to HCl and affect ACh release, causing changes in esophageal motor function similar to esophagitis (Cheng L, Cao W, Fiocchi C, Behar J, Biancani P, and Harnett KM. Acetylcholine 118-121 interleukin 6 Homo sapiens 52-56 16439466-3 2006 We therefore examined HCl-activated mechanisms for production of PAF and IL-6 in cat esophageal mucosa and circular muscle. Hydrochloric Acid 22-25 interleukin 6 Homo sapiens 73-77 16439466-7 2006 PAF and IL-6 levels in MS-HCl and mucosa were significantly elevated over control. Hydrochloric Acid 26-29 interleukin 6 Homo sapiens 8-12 16723241-1 2006 OBJECTIVE: Lactate levels after cardiac surgery are influenced by different proinflammatory (TNF, IL-6, IL-8) and anti-inflammatory (IL-10) cytokines. Lactic Acid 11-18 interleukin 6 Homo sapiens 98-102 16688773-16 2006 The authors postulated that high IL-6 or ghrelin levels inhibit testosterone synthesis, although a secondary effect at the hypothalamic-pituitary levels cannot be excluded. Testosterone 64-76 interleukin 6 Homo sapiens 33-37 16439466-9 2006 PAF-receptor mRNA levels were not detected by RT-PCR in normal mucosa, but were significantly elevated after exposure to HCl, indicating that HCl causes production of PAF and expression of PAF receptors in esophageal mucosa and that PAF causes production of IL-6. Hydrochloric Acid 121-124 interleukin 6 Homo sapiens 258-262 16439466-9 2006 PAF-receptor mRNA levels were not detected by RT-PCR in normal mucosa, but were significantly elevated after exposure to HCl, indicating that HCl causes production of PAF and expression of PAF receptors in esophageal mucosa and that PAF causes production of IL-6. Hydrochloric Acid 142-145 interleukin 6 Homo sapiens 258-262 16439466-11 2006 In the circular muscle, PAF causes production of additional IL-6 that activates NADPH oxidase to induce production of H(2)O(2). Hydrogen Peroxide 118-126 interleukin 6 Homo sapiens 60-64 16439466-1 2006 Platelet-activating factor (PAF) and interleukin-6 (IL-6) are produced in the esophagus in response to HCl and affect ACh release, causing changes in esophageal motor function similar to esophagitis (Cheng L, Cao W, Fiocchi C, Behar J, Biancani P, and Harnett KM. Hydrochloric Acid 103-106 interleukin 6 Homo sapiens 52-56 16439466-1 2006 Platelet-activating factor (PAF) and interleukin-6 (IL-6) are produced in the esophagus in response to HCl and affect ACh release, causing changes in esophageal motor function similar to esophagitis (Cheng L, Cao W, Fiocchi C, Behar J, Biancani P, and Harnett KM. Acetylcholine 118-121 interleukin 6 Homo sapiens 37-50 16731790-4 2006 Our results show for the first time that testosterone-replacement therapy is associated with a reduction or complete abrogation of spontaneous ex vivo production of IL-1beta, IL-6 and TNFalpha by APCs. Testosterone 41-53 interleukin 6 Homo sapiens 175-179 16842669-9 2006 IL-6/-572 C/G is related to total cholesterol (OR 1.76, 95% CI: 1.05 - 3.16, P < 0.05) and triglyceride (OR = 2.51, 95% CI: 1.04 - 6.45, P < 0.05), respectively. Cholesterol 34-45 interleukin 6 Homo sapiens 0-4 16859130-1 2006 OBJECTIVE: To investigate the effects of inflammation cytokines, (FK506) and cyclosporine (CSA) on albumin secretion, and the effects of FK506 and CSA on the IL-6 induced suppression of albumin synthesis in cultured human hepatocytes. Cyclosporine 147-150 interleukin 6 Homo sapiens 158-162 16842669-9 2006 IL-6/-572 C/G is related to total cholesterol (OR 1.76, 95% CI: 1.05 - 3.16, P < 0.05) and triglyceride (OR = 2.51, 95% CI: 1.04 - 6.45, P < 0.05), respectively. Triglycerides 94-106 interleukin 6 Homo sapiens 0-4 16566943-7 2006 RESULTS: IL-6 concentrations were lower in the steroid group at 4 and 8 h post-operatively (P < 0.0001). Steroids 47-54 interleukin 6 Homo sapiens 9-13 16413037-10 2006 The inhibition of ICAM-1 gene expression by 15d-PGJ(2) was abrogated by NAC and glutathione in IL-6-treated ECs. Glutathione 80-91 interleukin 6 Homo sapiens 95-99 16040142-15 2006 Statistical analysis revealed that testosterone treatment prior to stent implantation attenuated IL-6 and hs-CRP levels significantly (P=0.042 and P=0.043; respectively). Testosterone 35-47 interleukin 6 Homo sapiens 97-101 16040142-16 2006 CONCLUSIONS: The present study shows that 3 weeks testosterone treatment prior to intracoronary stenting results in a significant suppression in hs-CRP and IL-6 levels after the stent implantation. Testosterone 50-62 interleukin 6 Homo sapiens 156-160 16514109-8 2006 The IL-6 response to exercise was attenuated during cycling with supplemental oxygen. Oxygen 78-84 interleukin 6 Homo sapiens 4-8 16514109-11 2006 CONCLUSION: Short-term supplementary oxygen does not affect basal systemic inflammation and oxidative stress but prevents exercise-induced oxidative stress in normoxemic, muscle-wasted patients with COPD, and attenuates plasma IL-6 response. Oxygen 37-43 interleukin 6 Homo sapiens 227-231 16670485-8 2006 In primary cultures, 17beta-estradiol caused a significant decrease of IL-6 and IL-8 gene expression, but had no effect on the levels of IL-1beta, MMP-2, and MMP-9 gene expression. Estradiol 21-37 interleukin 6 Homo sapiens 71-75 16524883-6 2006 Dexamethasone potentiated IL-6 induction of the gammaFBG promoter 2.3-fold in both HepG2 and A549 cells for a combined increase in promoter activity of 70-fold or 4.5-fold, respectively. Dexamethasone 0-13 interleukin 6 Homo sapiens 26-30 16524883-7 2006 Dexamethasone potentiation is likely due to the induction of IL-6-receptor expression as well as prolonged intensity and duration of Stat3 activation. Dexamethasone 0-13 interleukin 6 Homo sapiens 61-65 20085228-3 2006 The results of in vitro cytotoxic activity of the mixture of spirostanol saponins against cell lines melanoma B16 and sarcoma XC and human fibroblasts HSF are also reported. Spirostans 61-72 interleukin 6 Homo sapiens 151-154 16137694-7 2006 Rosiglitazone reduced the incremental area under the curves (dAUCs) for IL-6 (-63%, p<0.01) and IL-8 (-16%, p<0.05). Rosiglitazone 0-13 interleukin 6 Homo sapiens 72-76 16137694-9 2006 CONCLUSIONS: Rosiglitazone attenuated the postprandial increases of neutrophils, IL-6 and IL-8 in patients with type 2 diabetes. Rosiglitazone 13-26 interleukin 6 Homo sapiens 81-85 16137694-12 2006 Rosiglitazone attenuated the postprandial increases of neutrophils, IL-6 and IL-8 in patients with type 2 diabetes. Rosiglitazone 0-13 interleukin 6 Homo sapiens 68-72 16651441-1 2006 We have analyzed in molecular detail how soy isoflavones (genistein, daidzein, and biochanin A) suppress nuclear factor-kappaB (NF-kappaB)-driven interleukin-6 (IL6) expression. Isoflavones 45-56 interleukin 6 Homo sapiens 146-159 16651441-1 2006 We have analyzed in molecular detail how soy isoflavones (genistein, daidzein, and biochanin A) suppress nuclear factor-kappaB (NF-kappaB)-driven interleukin-6 (IL6) expression. Isoflavones 45-56 interleukin 6 Homo sapiens 161-164 16651441-3 2006 Our results in estrogen-unresponsive fibroblasts, mitogen- and stress-activated protein kinase (MSK) knockout cells, and estrogen receptor (ER)-deficient breast tumor cells show that phytoestrogenic isoflavones can selectively block nuclear NF-kappaB transactivation of specific target genes (in particular IL6), independently of their estrogenic activity. Isoflavones 199-210 interleukin 6 Homo sapiens 307-310 16547804-0 2006 Histamine and PGE(2) stimulate the production of interleukins -6 and -8 by human articular chondrocytes in vitro. Histamine 0-9 interleukin 6 Homo sapiens 49-71 16641887-1 2006 Pyruvic acid, an intermediate metabolite of glucose, an effective scavenger of reactive oxygen species (ROS), inhibits tumor necrosis factor-alpha production and NF-kappaB signaling pathways, reduces circulating levels of HMGB1 (high mobility group B1), decreases COX-2 (cyclo-oxygenase-2), iNOS (inducible nitric oxide synthase), and IL-6 (interleukin-6) mRNA expression in liver, ileal mucosa, and colonic mucosa in animal models with endotoxemia. Glucose 44-51 interleukin 6 Homo sapiens 335-339 16641887-1 2006 Pyruvic acid, an intermediate metabolite of glucose, an effective scavenger of reactive oxygen species (ROS), inhibits tumor necrosis factor-alpha production and NF-kappaB signaling pathways, reduces circulating levels of HMGB1 (high mobility group B1), decreases COX-2 (cyclo-oxygenase-2), iNOS (inducible nitric oxide synthase), and IL-6 (interleukin-6) mRNA expression in liver, ileal mucosa, and colonic mucosa in animal models with endotoxemia. Glucose 44-51 interleukin 6 Homo sapiens 341-354 16618780-0 2006 Inhibition of p38 by vitamin D reduces interleukin-6 production in normal prostate cells via mitogen-activated protein kinase phosphatase 5: implications for prostate cancer prevention by vitamin D. Vitamin D 21-30 interleukin 6 Homo sapiens 39-52 16525642-8 2006 The combination of DHMEQ with cisplatin produced unexpected significant decrease in c-IAP-2 and Bcl-XS mRNAs as well as additive decrease (IL-6, NAIP and, after 16 h, Bcl-XL) or increase (XIAP at 8 h) in gene expression. Cisplatin 30-39 interleukin 6 Homo sapiens 139-143 16410784-4 2006 Addition of the hydrolysis-resistant ATP analogue, adenosine 5"-O-(3-thiotriphosphate) (ATPgammaS), to subconfluent cultures of the human microvascular endothelial cell-1 (HMEC-1) cell line led to a dose- and time-dependent increase in release of IL-6, IL-8, monocyte chemoattractant protein-1, and growth-regulated oncogene alpha. adenosine 5'-O-(3-thiotriphosphate) 51-86 interleukin 6 Homo sapiens 247-251 16322071-6 2006 Gallic acid decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated pro-inflammatory cytokine gene expression and production such as TNF-alpha and IL-6 in human mast cells. Tetradecanoylphorbol Acetate 26-57 interleukin 6 Homo sapiens 178-182 16516857-5 2006 Pharmacological inhibitor of PI3K failed to inhibit IL-6-mediated VEGF overexpression, while blocking ERK1/2 with PD98059 could abolish IL-6-induced KDR overexpression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 114-121 interleukin 6 Homo sapiens 136-140 16831922-5 2006 PGE2 also stimulated IL-6 production, and IL-6, in turn, increased PGE2 secretion, COX-2, and EP4/EP2 expression in bone cells. Dinoprostone 0-4 interleukin 6 Homo sapiens 21-25 16831922-5 2006 PGE2 also stimulated IL-6 production, and IL-6, in turn, increased PGE2 secretion, COX-2, and EP4/EP2 expression in bone cells. Dinoprostone 0-4 interleukin 6 Homo sapiens 42-46 16831922-5 2006 PGE2 also stimulated IL-6 production, and IL-6, in turn, increased PGE2 secretion, COX-2, and EP4/EP2 expression in bone cells. Dinoprostone 67-71 interleukin 6 Homo sapiens 42-46 16595469-10 2006 RESULTS: Both titanium and polymethylmethacrylate particles potently inhibited interleukin-6-induced STAT3 activation in human osteoclast precursor cells. Titanium 14-22 interleukin 6 Homo sapiens 79-92 16595469-11 2006 Inhibition of p38 mitogen-activated protein kinase, which is activated by titanium and polymethylmethacrylate, reversed the inhibitory effects of these particles on interleukin-6 signaling, whereas inhibition of ERK and JNK mitogen-activated protein kinases (which are also activated by both types of wear debris) had no effect. Titanium 74-82 interleukin 6 Homo sapiens 165-178 16595469-12 2006 Titanium and polymethylmethacrylate also both induced expression of SOCS3, an inhibitor of interleukin-6 signaling. Titanium 0-8 interleukin 6 Homo sapiens 91-104 16595469-13 2006 In addition to its effects on interleukin-6 signaling, titanium also profoundly inhibited the interferon-gamma-induced activation of STAT1 and the expression of interferon-gamma-inducible genes, whereas polymethylmethacrylate had no effect on interferon-gamma signaling. Titanium 55-63 interleukin 6 Homo sapiens 30-43 16595469-14 2006 CONCLUSIONS: Titanium inhibits both interferon-gamma and interleukin-6 signaling in human osteoclast precursor cells, whereas polymethylmethacrylate bone cement inhibits only the latter. Titanium 13-21 interleukin 6 Homo sapiens 57-70 16734992-8 2006 RESULTS: Both mean TNF-alpha and IL-6 were increased following S&RP ; however, the observed increases were not statistically significant. Adenosine Monophosphate 65-68 interleukin 6 Homo sapiens 33-37 29350843-3 2006 Functional studies revealed that dexamethasone (DEX) inhibited phorbol 12-myristate 13-acetate/ionomycin-induced tumor necrosis factor alpha and interleukin-6 production to a significantly lesser extent in monocytes than T cells. Dexamethasone 33-46 interleukin 6 Homo sapiens 145-158 16461744-3 2006 Functional studies revealed that dexamethasone (DEX) inhibited phorbol 12-myristate 13-acetate/ionomycin-induced tumor necrosis factor alpha and interleukin-6 production to a significantly lesser extent in monocytes than T cells. Dexamethasone 33-46 interleukin 6 Homo sapiens 145-158 16461744-3 2006 Functional studies revealed that dexamethasone (DEX) inhibited phorbol 12-myristate 13-acetate/ionomycin-induced tumor necrosis factor alpha and interleukin-6 production to a significantly lesser extent in monocytes than T cells. Dexamethasone 48-51 interleukin 6 Homo sapiens 145-158 16461744-3 2006 Functional studies revealed that dexamethasone (DEX) inhibited phorbol 12-myristate 13-acetate/ionomycin-induced tumor necrosis factor alpha and interleukin-6 production to a significantly lesser extent in monocytes than T cells. Ionomycin 95-104 interleukin 6 Homo sapiens 145-158 29350843-3 2006 Functional studies revealed that dexamethasone (DEX) inhibited phorbol 12-myristate 13-acetate/ionomycin-induced tumor necrosis factor alpha and interleukin-6 production to a significantly lesser extent in monocytes than T cells. Dexamethasone 48-51 interleukin 6 Homo sapiens 145-158 29350843-3 2006 Functional studies revealed that dexamethasone (DEX) inhibited phorbol 12-myristate 13-acetate/ionomycin-induced tumor necrosis factor alpha and interleukin-6 production to a significantly lesser extent in monocytes than T cells. Ionomycin 95-104 interleukin 6 Homo sapiens 145-158 16498607-9 2006 IL-6 inversely correlated with lipoprotein(a) (r = -0.321 at T1) and LDL-cholesterol (r = -0.418 at T1). Cholesterol 73-84 interleukin 6 Homo sapiens 0-4 16257998-0 2006 All-trans retinoic acid modulates radiation-induced proliferation of lung fibroblasts via IL-6/IL-6R system. Tretinoin 10-23 interleukin 6 Homo sapiens 90-94 16257998-7 2006 Furthermore, IL-6 stimulated cell proliferation in dose-dependent manner but was overcome by pharmacological concentration of ATRA. Tretinoin 126-130 interleukin 6 Homo sapiens 13-17 16257998-9 2006 Finally, we demonstrated that IL-6 transcripts in the lung were upregulated at 2 mo after irradiation, and the effect was inhibited by the intraperitoneal administration of ATRA. Tretinoin 173-177 interleukin 6 Homo sapiens 30-34 16385087-4 2006 METHODS AND RESULTS: Metformin dose-dependently inhibited IL-1beta-induced release of the pro-inflammatory cytokines IL-6 and IL-8 in ECs, SMCs, and Mphis. Metformin 21-30 interleukin 6 Homo sapiens 117-121 16624773-5 2006 RESULTS: In both groups plasma IL-6 and D-dimer levels showed significant increase at T(1), T(2) and T(3) in comparison with those at T(0), and their levels were significantly lower in morphine group than in ropivacaine group at T(1), T(2) and T(3). Morphine 185-193 interleukin 6 Homo sapiens 31-35 16624773-6 2006 CONCLUSION: Epidural morphine can lower plasma IL-6 and D-dimer levels and correct blood hypercoagulability in patients undergoing total hip replacement. Morphine 21-29 interleukin 6 Homo sapiens 47-51 16407171-3 2006 By 15-30 min after interleukin-6 (IL-6) treatment, up to two-thirds of cytoplasmic Tyr-phosphorylated STAT3 can be associated with the purified early endosome fraction (Rab-5-, EEA1-, transferrin receptor-, and clathrin-positive fraction). Tyrosine 83-86 interleukin 6 Homo sapiens 34-38 16467451-9 2006 The two coding variants, Pro32Ser (present only in black patients, 10% Ser allele) and Asp162Val (present only in white patients, 1% Val), were associated with lower levels of IL-6 and higher levels of albumin. Serine 30-33 interleukin 6 Homo sapiens 176-180 16505650-8 2006 MEASUREMENT AND MAIN RESULTS: Postoperative serum levels of both interleukin-6 and interleukin-8 increased significantly over baseline, but the peak levels observed 4 hrs postoperatively were significantly lower in the atorvastatin group. Atorvastatin 219-231 interleukin 6 Homo sapiens 65-78 16562828-1 2006 Crude extracts of Witheringia solanacea leaves showed inhibition of NF-kappaB activation at 100 microg/mL induced by phorbol 12-myristate-13-acetate (PMA) in HeLa cells stably transfected with a luciferase reporter gene controlled by the IL-6 promoter. Tetradecanoylphorbol Acetate 150-153 interleukin 6 Homo sapiens 238-242 16736416-13 2006 Urinary excretion of IL-6 was significantly related with urinary IL-1 beta, both expressed as pg/ml/mg of urinary creatinine (r=0.85, p<0.0001). Creatinine 114-124 interleukin 6 Homo sapiens 21-25 16476030-5 2006 RESULTS: Following the dexamethasone treatment, the levels of TNF-alpha, IL-1-alpha, IL-6, and IL-8 were decreased significantly, and IL-1-alpha and IL-8 were detected at a level without a statistically significant difference from controls. Dexamethasone 23-36 interleukin 6 Homo sapiens 85-89 16463434-8 2006 IL-6 concentrations were inversely correlated with HDL cholesterol (p = 0.01). Cholesterol 55-66 interleukin 6 Homo sapiens 0-4 16054696-5 2006 Here, we show that pravastatin and simvastatin prevent the induction of CRP expression in human hepatoma Hep3B cells exposed to proinflammatory cytokines IL-6 and IL-1beta The nitric oxide (NO) donor, sodium nitroprusside, also prevented the induction of CRP expression while the CRP inducers IL-6 and IL-1beta were present with the cells. Nitric Oxide 176-188 interleukin 6 Homo sapiens 154-158 16405429-11 2006 CRP (6.1 mg/dL vs. 3.1 mg/dL; P < 0.001) and IL-6 (295 ng/mL vs. 122 ng/mL; P = 0.001) were decreased during steroid therapy, but not PCT (2.3 ng/dL vs. 2.0 ng/dL; n.s.). Steroids 112-119 interleukin 6 Homo sapiens 48-52 16503719-7 2006 Atorvastatin significantly reduced the production of epithelial neutrophil-activating peptide-78, interleukin-6, interleukin-8, and monocyte chemotactic protein-1 (p<0.001 to p<0.05) in a concentration-dependent manner without affecting basal production of interleukin-10, fibroblast growth factor, and granulocyte colony stimulating factor. Atorvastatin 0-12 interleukin 6 Homo sapiens 98-111 16767331-8 2006 The IL-6 showed better indices on the day of suspicion diagnosis, day 0 (S: 88.9%, Sp: 80.0%, PPV: 76.2%, NPV: 90.9%), followed by the C-reactive protein (S: 94.0%, Sp: 78.3%, PPV: 77.3%, NPV: 94.7%) 24 hours later. TFF2 protein, human 83-85 interleukin 6 Homo sapiens 4-8 16443681-9 2006 Furthermore, hydrogen peroxide treatment led to a greater accumulation of several inflammatory cytokines (IL-6, IL-7, IL-16, and IL-17) and increased necrosis in older cells. Hydrogen Peroxide 13-30 interleukin 6 Homo sapiens 106-110 16490592-8 2006 Resveratrol also down-regulated the expression of NF-kappaB-regulated gene products by Western blot analysis, gelatin zymography, and enzyme-linked immunosorbent assay, including interleukin-6, Bcl-2, Bcl-xL, XIAP, c-IAP, vascular endothelial growth factor (VEGF), and matrix metalloproteinase-9 (MMP-9), which modulates an array of signals controlling cellular survival and proliferation and tumor promotion. Resveratrol 0-11 interleukin 6 Homo sapiens 179-192 16418778-15 2006 In HCC1 cells, adenosine has a potent stimulatory action on IL-6 secretion but an inhibitory action on OPG expression. Adenosine 15-24 interleukin 6 Homo sapiens 60-64 16418778-0 2006 Human osteoblast precursors produce extracellular adenosine, which modulates their secretion of IL-6 and osteoprotegerin. Adenosine 50-59 interleukin 6 Homo sapiens 96-100 16472586-11 2006 A similar relationship existed between the deltaACTH/deltacortisol ratio and the IL-6 levels. deltaacth 43-52 interleukin 6 Homo sapiens 81-85 16676702-0 2006 Carbohydrate influences plasma interleukin-6 but not C-reactive protein or creatine kinase following a 32-km mountain trail race. Carbohydrates 0-12 interleukin 6 Homo sapiens 31-44 16676702-1 2006 Attenuation of exercise-induced interleukin-6 (IL-6) responses by carbohydrate (CHO) has been demonstrated in studies comparing controlled doses (> or = 0.9 g x kg(-1) x h(-1)) to placebo, but not in studies of voluntary intake. Carbohydrates 66-78 interleukin 6 Homo sapiens 47-51 16491457-4 2006 Coumestrol, daidzein and genistein stimulate the expression of the ERE-dependent reporter in MVLN cells and repress the activity of the IL-6 promoter in U2OS cells in a dose-dependent manner. Coumestrol 0-10 interleukin 6 Homo sapiens 136-140 16418778-2 2006 Adenosine stimulated IL-6 but inhibited osteoprotegerin secretion, suggesting that adenosine is a newly described regulator of progenitor cell function. Adenosine 0-9 interleukin 6 Homo sapiens 21-25 16433960-0 2006 Calcium-enriched casein phosphopeptide stimulates release of IL-6 cytokine in human epithelial intestinal cell line. Calcium 0-7 interleukin 6 Homo sapiens 61-65 15890495-2 2006 We investigated whether the IL-6 response would habituate in response to a repetitively applied mental stressor and whether cortisol reactivity would show a relationship with IL-6 reactivity. Hydrocortisone 124-132 interleukin 6 Homo sapiens 175-179 16433737-10 2006 Ethanol (50 mM) attenuated the IL-6-induced increase in hepcidin expression in HuH-7 cells (9-fold to a 4-fold increase) but not in hepatocytes. Ethanol 0-7 interleukin 6 Homo sapiens 31-35 16118251-5 2006 Suppression of basal glucose R(a) correlated with plasma adiponectin (r=0.44, P=0.02) and inversely with plasma IL-6 (r=-0.49, P<0.001). Glucose 21-28 interleukin 6 Homo sapiens 112-116 16118251-6 2006 Stimulation of glucose R(d) correlated directly with adiponectin (r=0.48, P<0.01) and inversely with IL-6 (r=-0.49, P=0.02). Glucose 15-22 interleukin 6 Homo sapiens 104-108 16859503-7 2006 Adhered monocytes, after 3-day preincubation with IL-10 and M-CSF, could produce more IL-1beta and IL-6 in response to TNF-alpha in the presence of dibutyryl cAMP, as compared with the cells preincubated with or without IL-10 or M-CSF alone. Cyclic AMP 158-162 interleukin 6 Homo sapiens 99-103 16362041-6 2006 We found that the serine phosphorylation was crucial for TLR-induced interleukin 6 production and this process is regulated by TRAF6, a key adaptor molecule for the TLR pathway. Serine 18-24 interleukin 6 Homo sapiens 69-82 16983933-15 2006 Steroids were administered after the diagnosis of pre-EPS, with the result that the IL-6 level rapidly decreased and the D/P Cr and D/P of small molecules and macromolecules slightly decreased. Steroids 0-8 interleukin 6 Homo sapiens 84-88 17042956-8 2006 Upon examination of signaling pathways involved in PGE2 and IL-6 production, we found that HNE-induced PGE2 release was abrogated by SB202190, a p38 mitogen-activated protein kinase (MAPK) inhibitor. Dinoprostone 103-107 interleukin 6 Homo sapiens 60-64 17167225-0 2006 Increased glucose uptake and metabolism in mesangial cells overexpressing glucose transporter 1 increases interleukin-6 and vascular endothelial growth factor production: role of AP-1 and HIF-1alpha. Glucose 10-17 interleukin 6 Homo sapiens 106-119 17201070-4 2006 Several mechanisms may link muscle contractions to IL-6 synthesis: Changes in calcium homeostasis, impaired glucose availability, and increased formation of reactive oxygen species (ROS) are all capable of activating transcription factors known to regulate IL-6 synthesis. Calcium 78-85 interleukin 6 Homo sapiens 51-55 17201070-4 2006 Several mechanisms may link muscle contractions to IL-6 synthesis: Changes in calcium homeostasis, impaired glucose availability, and increased formation of reactive oxygen species (ROS) are all capable of activating transcription factors known to regulate IL-6 synthesis. Calcium 78-85 interleukin 6 Homo sapiens 257-261 17201070-4 2006 Several mechanisms may link muscle contractions to IL-6 synthesis: Changes in calcium homeostasis, impaired glucose availability, and increased formation of reactive oxygen species (ROS) are all capable of activating transcription factors known to regulate IL-6 synthesis. Reactive Oxygen Species 157-180 interleukin 6 Homo sapiens 51-55 17201070-4 2006 Several mechanisms may link muscle contractions to IL-6 synthesis: Changes in calcium homeostasis, impaired glucose availability, and increased formation of reactive oxygen species (ROS) are all capable of activating transcription factors known to regulate IL-6 synthesis. Reactive Oxygen Species 157-180 interleukin 6 Homo sapiens 257-261 17201070-4 2006 Several mechanisms may link muscle contractions to IL-6 synthesis: Changes in calcium homeostasis, impaired glucose availability, and increased formation of reactive oxygen species (ROS) are all capable of activating transcription factors known to regulate IL-6 synthesis. Reactive Oxygen Species 182-185 interleukin 6 Homo sapiens 51-55 17201070-4 2006 Several mechanisms may link muscle contractions to IL-6 synthesis: Changes in calcium homeostasis, impaired glucose availability, and increased formation of reactive oxygen species (ROS) are all capable of activating transcription factors known to regulate IL-6 synthesis. Reactive Oxygen Species 182-185 interleukin 6 Homo sapiens 257-261 16477538-5 2006 Serum IL-6 and TNFalpha concentrations were elevated during glucose loading (for each comparison, p < 0.01). Glucose 60-67 interleukin 6 Homo sapiens 6-10 16477538-7 2006 Serum IL-6 and TNFalpha concentration significantly correlated with insulin and glucose in IGT group (for each comparison, p < 0.01). Glucose 80-87 interleukin 6 Homo sapiens 6-10 16332510-6 2006 Results showed that nicotine suppressed the LPS induced production of IL-6 and IL-8 in both cell lines. Nicotine 20-28 interleukin 6 Homo sapiens 70-74 16997791-7 2006 Furthermore, AIAE attenuated the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis factor-alpha and interleukin-6 secretion in human mast cells. Tetradecanoylphorbol Acetate 33-64 interleukin 6 Homo sapiens 138-151 16997791-7 2006 Furthermore, AIAE attenuated the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis factor-alpha and interleukin-6 secretion in human mast cells. Calcium 70-77 interleukin 6 Homo sapiens 138-151 16423036-3 2006 Stimulation of HCECs with the TLR3 agonist poly(I:C) induced the activation of nuclear factor (NF)-kappaB and production of the proinflammatory cytokine interleukin (IL)-6 and the chemokine IL-8. Poly I 43-49 interleukin 6 Homo sapiens 153-171 16423036-3 2006 Stimulation of HCECs with the TLR3 agonist poly(I:C) induced the activation of nuclear factor (NF)-kappaB and production of the proinflammatory cytokine interleukin (IL)-6 and the chemokine IL-8. Carbon 50-52 interleukin 6 Homo sapiens 153-171 16357489-12 2006 In addition, DAAE decreased TNF-alpha and IL-6 gene expression and production in human mast cells stimulated by phorbol-12-myristate-13-acetate (PMA) plus calcium ionophore A23187. Tetradecanoylphorbol Acetate 112-143 interleukin 6 Homo sapiens 42-46 16824780-9 2006 These results indicate that chorion cell-derived interleukin-6 is partly responsible for monocyte differentiation to macrophages capable of generating superoxide anion. Superoxides 151-167 interleukin 6 Homo sapiens 49-62 16357489-12 2006 In addition, DAAE decreased TNF-alpha and IL-6 gene expression and production in human mast cells stimulated by phorbol-12-myristate-13-acetate (PMA) plus calcium ionophore A23187. Tetradecanoylphorbol Acetate 145-148 interleukin 6 Homo sapiens 42-46 16711008-0 2006 Effects of 17beta-estradiol on the expression of IL-6, IL-11 and NF-kappaB in human MG-63 osteoblast-like cell line. Estradiol 11-27 interleukin 6 Homo sapiens 49-53 16328020-12 2006 However, in the second sample, nicotine increased secretion of Il-6 but estradiol did not oppose this effect. Nicotine 31-39 interleukin 6 Homo sapiens 63-67 16328020-14 2006 These results suggest that nicotine affects bone metabolism by modulating proliferation, and Il-6 and TNF-alpha secretion. Nicotine 27-35 interleukin 6 Homo sapiens 93-97 16711008-1 2006 In order to characterize the effects of 17beta-estradiol (17beta-E2) on the expression of IL-6, IL-11 and NF-kappaB in the human MG-63 osteoblast-like cell line, the expression of IL-6 was detected by RT-PCR, Northern blot and Western blot. Estradiol 40-56 interleukin 6 Homo sapiens 90-94 16501663-5 2006 In univariate analysis age, hypertension, diabetes, smoking, moderate alcohol use, total homocysteine, carotid intima media thickness, and body mass index were positively associated with IL-6 levels. Alcohols 70-77 interleukin 6 Homo sapiens 187-191 16388388-6 2006 Arachidonic acid stimulated leukotriene B(4) and interleukin 6 release as well as prostaglandin E(2) biosynthesis in SZ95 sebocytes, induced abundant increase in neutral lipids and down-regulated peroxisome proliferator-activated receptor-alpha, but not receptor-gamma1 mRNA levels, which were the predominant peroxisome proliferator-activated receptor isotypes in SZ95 sebocytes. Arachidonic Acid 0-16 interleukin 6 Homo sapiens 49-62 17077645-5 2006 OBJECTIVE: It was the aim of this study to investigate the role of genetic IL-6 deficiency in trinitrobenzene sulfonic acid (TNBS)-mediated colitis, an experimental model inflammation that shares several features with Crohn"s disease in humans. Trinitrobenzenesulfonic Acid 94-123 interleukin 6 Homo sapiens 75-79 16226391-7 2006 The pathogenesis of ACD had been poorly understood, but recently it has been shown that increased Il-6 upregulates the hepatic production of hepcidin, which, by binding to its cellular receptor, ferroportin, causes anemia by blocking iron export from enterocytes and macrophages. Iron 234-238 interleukin 6 Homo sapiens 98-102 17077645-5 2006 OBJECTIVE: It was the aim of this study to investigate the role of genetic IL-6 deficiency in trinitrobenzene sulfonic acid (TNBS)-mediated colitis, an experimental model inflammation that shares several features with Crohn"s disease in humans. Trinitrobenzenesulfonic Acid 125-129 interleukin 6 Homo sapiens 75-79 16543969-5 2006 17beta-dihydroequilenin and 17beta-estradiol at a concentration of 1 microM reduced IL-1alpha-induced up regulation of IL-6, IL-8 and MCP-1 close to control levels. Estradiol 28-44 interleukin 6 Homo sapiens 119-123 16310043-10 2006 The secretion of IL-6 during day 7 of culture (standardised by taking natural logarithms) was increased markedly by the addition of TNF-alpha but unaltered by removing hydrocortisone, insulin or serum. Hydrocortisone 168-182 interleukin 6 Homo sapiens 17-21 17441364-8 2006 Serum creatinine correlated with IL-6, IL-18, TNFalpha, sTNFRII and hsCRP levels and serum urea-with TNFalpha, sTNFRII, IL-6 and IL-18. Creatinine 6-16 interleukin 6 Homo sapiens 33-37 16005497-5 2006 RESULTS: We found that IL-1beta and IL-6 levels were significantly increased in the coronary sinus of patients receiving either bare, paclitaxel- or sirolimus-eluting stents 20 min after stent implantation as compared with basal concentrations. Paclitaxel 134-144 interleukin 6 Homo sapiens 36-40 16005497-5 2006 RESULTS: We found that IL-1beta and IL-6 levels were significantly increased in the coronary sinus of patients receiving either bare, paclitaxel- or sirolimus-eluting stents 20 min after stent implantation as compared with basal concentrations. Sirolimus 149-158 interleukin 6 Homo sapiens 36-40 16150460-0 2005 Resveratrol suppresses IL-6-induced ICAM-1 gene expression in endothelial cells: effects on the inhibition of STAT3 phosphorylation. Resveratrol 0-11 interleukin 6 Homo sapiens 23-27 16869254-8 2006 Oxygen-dependent killing was controlled mostly by IL-6 during the pre-operative period, and by this plus TNF-alpha 24 hours after surgery. Oxygen 0-6 interleukin 6 Homo sapiens 50-54 16297993-8 2005 Because low levels of IL-6 might contribute to endothelial growth retardation as well as to the enhancement of nitric oxide synthesis, we hypothesize a central role of IL-6 in modulating microvascular endothelial cell behaviour in modeled microgravity. Nitric Oxide 111-123 interleukin 6 Homo sapiens 168-172 15936049-10 2005 Furthermore, LAE decreased the secretion of TNF-alpha and IL-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated human mast cells. Tetradecanoylphorbol Acetate 66-97 interleukin 6 Homo sapiens 58-62 15936049-10 2005 Furthermore, LAE decreased the secretion of TNF-alpha and IL-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated human mast cells. Tetradecanoylphorbol Acetate 99-102 interleukin 6 Homo sapiens 58-62 15936049-10 2005 Furthermore, LAE decreased the secretion of TNF-alpha and IL-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated human mast cells. Calcium 109-116 interleukin 6 Homo sapiens 58-62 16150460-3 2005 In this study we tested the effects of resveratrol upon both IL-6-induced ICAM-1 gene expression and its underlying signaling pathways in endothelial cells (ECs). Resveratrol 39-50 interleukin 6 Homo sapiens 61-65 16150460-4 2005 Resveratrol was found to inhibit both TNFalpha- and IL-6-induced ICAM-1 gene expression at the promoter, transcriptional and protein levels. Resveratrol 0-11 interleukin 6 Homo sapiens 52-56 16150460-5 2005 Resveratrol also abrogates the tyr705 phosphorylation of STAT3 in IL-6-treated ECs, in a dose- and time-dependent manner. Resveratrol 0-11 interleukin 6 Homo sapiens 66-70 16150460-9 2005 Conversely, exposure of ECs to a NOS inhibitor reversed the effects of resveratrol upon IL-6-induced STAT3 phosphorylation. Resveratrol 71-82 interleukin 6 Homo sapiens 88-92 16150460-11 2005 In summary, we demonstrate for the first time that resveratrol inhibits IL-6-induced ICAM-1 gene expression, in part, by interfering with Rac-mediated pathways via the attenuation of STAT3 phosphorylation. Resveratrol 51-62 interleukin 6 Homo sapiens 72-76 16332649-10 2005 PUFA:SFA in phospholipids and CEs were associated inversely with interleukin 6 (P < 0.05 for both). Phospholipids 12-25 interleukin 6 Homo sapiens 65-78 16051518-8 2005 Serum levels of IL-6, TNF-alpha and sVCAM-1 were decreased in the atorvastatin-treated group (p < 0.05 for all), but remained unaffected in the other two groups (p = NS for all). Atorvastatin 66-78 interleukin 6 Homo sapiens 16-20 16275618-7 2005 Furthermore, GRJ decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated TNF-alpha and IL-6 secretion in human mast cells. Tetradecanoylphorbol Acetate 31-62 interleukin 6 Homo sapiens 118-122 16354411-7 2005 Dexamethasone (100 nM) not only inhibited PGE2, PGF(2alpha), IL-6 and IL-8 production but also strongly suppressed the expression of COX-2 mRNA and protein. Dexamethasone 0-13 interleukin 6 Homo sapiens 61-65 16204370-10 2005 During the pharmacological trial, the testosterone/progestin group exhibited a marked increase of IL-6 concentrations (P < 0.001), whereas these decreased in the testosterone/placebo group (P = 0.03). Testosterone 38-50 interleukin 6 Homo sapiens 98-102 16155293-1 2005 We previously demonstrated that trans-10, cis-12 conjugated linoleic acid (CLA) reduced the triglyceride content of human adipocytes by activating mitogen-activated protein kinase kinase/extracellular signal-related kinase (MEK/ERK) signaling via interleukins (IL) 6 and 8. Linoleic Acid 60-73 interleukin 6 Homo sapiens 247-272 19079903-4 2005 It is suggested that the relationship between vitamin D and low-intensity chronic inflammation and insulin resistance in T2DM can be mediated in part by the immune-modulating properties of the active form of vitamin D (1-alpha,25-dihydroxyvitamin D3; 1,25(OH)2D3), which is able to down regulate the production of pro-inflammatory cytokines - particularly TNF-alpha, and IL-6. Vitamin D 46-55 interleukin 6 Homo sapiens 371-375 19079903-4 2005 It is suggested that the relationship between vitamin D and low-intensity chronic inflammation and insulin resistance in T2DM can be mediated in part by the immune-modulating properties of the active form of vitamin D (1-alpha,25-dihydroxyvitamin D3; 1,25(OH)2D3), which is able to down regulate the production of pro-inflammatory cytokines - particularly TNF-alpha, and IL-6. Vitamin D 208-217 interleukin 6 Homo sapiens 371-375 16037543-4 2005 However, when circular muscle strips were exposed to supernatants of mucosa incubated in HCl (2-3 h, pH 5.8), contraction decreased, and the inhibition was partially reversed by an IL-6 antibody. Hydrochloric Acid 89-92 interleukin 6 Homo sapiens 181-185 16113665-0 2005 Optimizing the use of anti-interleukin-6 monoclonal antibody with dexamethasone and 140 mg/m2 of melphalan in multiple myeloma: results of a pilot study including biological aspects. Dexamethasone 66-79 interleukin 6 Homo sapiens 27-40 16113665-1 2005 Interleukin-6 (IL-6) is a major survival factor for multiple myeloma (MM) cells preventing apoptosis induced by dexamethasone (DEX) or chemotherapy. Dexamethasone 112-125 interleukin 6 Homo sapiens 0-13 16113665-1 2005 Interleukin-6 (IL-6) is a major survival factor for multiple myeloma (MM) cells preventing apoptosis induced by dexamethasone (DEX) or chemotherapy. Dexamethasone 112-125 interleukin 6 Homo sapiens 15-19 16113665-1 2005 Interleukin-6 (IL-6) is a major survival factor for multiple myeloma (MM) cells preventing apoptosis induced by dexamethasone (DEX) or chemotherapy. Dexamethasone 127-130 interleukin 6 Homo sapiens 0-13 16113665-1 2005 Interleukin-6 (IL-6) is a major survival factor for multiple myeloma (MM) cells preventing apoptosis induced by dexamethasone (DEX) or chemotherapy. Dexamethasone 127-130 interleukin 6 Homo sapiens 15-19 15978634-0 2005 Inhibitory effect of 6-hydroxy-7-methoxychroman-2-carboxylic acid phenylamide on nitric oxide and interleukin-6 production in macrophages. 6-hydroxy-7-methoxychroman-2-carboxylic acid phenylamide 21-77 interleukin 6 Homo sapiens 98-111 16255604-4 2005 A comparison of the detection limits for IL-6 using currently widely used CM-dextran and NHS-MHA shows an improvement by a factor of 3 using NHS-MHA. Dextrans 77-84 interleukin 6 Homo sapiens 41-45 16255604-5 2005 The detection limits for the monitoring of cytokines in spiked saline solutions and CCM were similar for TNF-alpha and slightly higher for IL-1 and IL-6. Sodium Chloride 63-69 interleukin 6 Homo sapiens 148-152 16255036-9 2005 Interleukin-6 (IL-6) was detectable in coculture supernatants, and both IL-6 and neutrophil adhesion were reduced in a dose-dependent manner by hydrocortisone added to cocultures. Hydrocortisone 144-158 interleukin 6 Homo sapiens 0-13 16255036-9 2005 Interleukin-6 (IL-6) was detectable in coculture supernatants, and both IL-6 and neutrophil adhesion were reduced in a dose-dependent manner by hydrocortisone added to cocultures. Hydrocortisone 144-158 interleukin 6 Homo sapiens 15-19 16255036-9 2005 Interleukin-6 (IL-6) was detectable in coculture supernatants, and both IL-6 and neutrophil adhesion were reduced in a dose-dependent manner by hydrocortisone added to cocultures. Hydrocortisone 144-158 interleukin 6 Homo sapiens 72-76 16037543-7 2005 IL-6 levels increased significantly in normal mucosa and supernatants in response to HCl, suggesting increased production and release of IL-6 by the mucosa. Hydrochloric Acid 85-88 interleukin 6 Homo sapiens 0-4 16037543-7 2005 IL-6 levels increased significantly in normal mucosa and supernatants in response to HCl, suggesting increased production and release of IL-6 by the mucosa. Hydrochloric Acid 85-88 interleukin 6 Homo sapiens 137-141 16037543-8 2005 IL-6 increased H2O2 levels in the circular muscle layer but not in mucosa. Hydrogen Peroxide 15-19 interleukin 6 Homo sapiens 0-4 16037543-10 2005 These data suggest that HCl-induced damage occurs first in the mucosa, leading to the production of IL-1beta and IL-6 but not H2O2. Hydrochloric Acid 24-27 interleukin 6 Homo sapiens 113-117 16037543-12 2005 In contrast, IL-6 is produced and released by the mucosa, eventually resulting in the production of H2O2 by the circular muscle, with this affecting circular muscle contraction. Hydrogen Peroxide 100-104 interleukin 6 Homo sapiens 13-17 16263508-5 2005 Exposure to OE-UDP, OE-DEP, UDP, DEP, and 2,3,7,8-tetrachlorodibenzo-p-dioxin led to a greater increase of interleukin (IL)-8, tumor necrosis factor-alpha, and cyclooxygenase-2 mRNA expression than did the stripped particles, whereas sUDP, sDEP, UDP, and DEP led to a greater production of C-reactive protein and IL-6 mRNA. Uridine Diphosphate 15-18 interleukin 6 Homo sapiens 313-317 16263508-5 2005 Exposure to OE-UDP, OE-DEP, UDP, DEP, and 2,3,7,8-tetrachlorodibenzo-p-dioxin led to a greater increase of interleukin (IL)-8, tumor necrosis factor-alpha, and cyclooxygenase-2 mRNA expression than did the stripped particles, whereas sUDP, sDEP, UDP, and DEP led to a greater production of C-reactive protein and IL-6 mRNA. dep 23-26 interleukin 6 Homo sapiens 313-317 16263508-5 2005 Exposure to OE-UDP, OE-DEP, UDP, DEP, and 2,3,7,8-tetrachlorodibenzo-p-dioxin led to a greater increase of interleukin (IL)-8, tumor necrosis factor-alpha, and cyclooxygenase-2 mRNA expression than did the stripped particles, whereas sUDP, sDEP, UDP, and DEP led to a greater production of C-reactive protein and IL-6 mRNA. Polychlorinated Dibenzodioxins 42-77 interleukin 6 Homo sapiens 313-317 16263508-5 2005 Exposure to OE-UDP, OE-DEP, UDP, DEP, and 2,3,7,8-tetrachlorodibenzo-p-dioxin led to a greater increase of interleukin (IL)-8, tumor necrosis factor-alpha, and cyclooxygenase-2 mRNA expression than did the stripped particles, whereas sUDP, sDEP, UDP, and DEP led to a greater production of C-reactive protein and IL-6 mRNA. Uridine Diphosphate 28-31 interleukin 6 Homo sapiens 313-317 16223626-9 2005 This was manifested by increased suppression of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) production by dexamethasone. Dexamethasone 127-140 interleukin 6 Homo sapiens 48-61 19758923-6 2005 CONCLUSION: After PCI in UA, cyclooxygenase-2 inhibitor rofecoxib added to atorvastatin reduced CRP and IL-6 levels more profoundly than atorvastatin alone at 3- and 6-month after intervention. Atorvastatin 75-87 interleukin 6 Homo sapiens 104-108 16183810-6 2005 Infants with arterial hypotension requiring dopamine treatment had an increase in IL-6 with a peak at 6 h of age. Dopamine 44-52 interleukin 6 Homo sapiens 82-86 16297323-6 2005 The levels of TNF-alpha and IL-6 were decreased much more obviously in GSH group compared with those in control group (P<0.05). Glutathione 71-74 interleukin 6 Homo sapiens 28-32 16324343-0 2005 [Effects of atorvastatin on plasma hypersensitive C-reactive protein and interleukin-6 in patients with acute cerebral infarction]. Atorvastatin 12-24 interleukin 6 Homo sapiens 73-86 16324343-1 2005 OBJECTIVE: To observe the effects of different doses of atorvastatin on the plasma hypersensitive C-reactive protein (hsCRP) and interleukin-6 (IL-6) in patients with acute cerebral infarction. Atorvastatin 56-68 interleukin 6 Homo sapiens 129-142 16324343-1 2005 OBJECTIVE: To observe the effects of different doses of atorvastatin on the plasma hypersensitive C-reactive protein (hsCRP) and interleukin-6 (IL-6) in patients with acute cerebral infarction. Atorvastatin 56-68 interleukin 6 Homo sapiens 144-148 15899942-8 2005 Taken together, our study suggests that IL-6 might influence glucose tolerance in part by regulation of the novel insulin-mimetic adipocytokine visfatin. Glucose 61-68 interleukin 6 Homo sapiens 40-44 16179737-6 2005 Furthermore, AXE attenuated the phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore (A23187)-stimulated tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 secretion in human mast cells. Tetradecanoylphorbol Acetate 32-63 interleukin 6 Homo sapiens 157-175 16179737-6 2005 Furthermore, AXE attenuated the phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore (A23187)-stimulated tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 secretion in human mast cells. Tetradecanoylphorbol Acetate 65-68 interleukin 6 Homo sapiens 157-175 16179737-6 2005 Furthermore, AXE attenuated the phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore (A23187)-stimulated tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 secretion in human mast cells. Calcium 75-82 interleukin 6 Homo sapiens 157-175 16184516-7 2005 IL-10 also synergized with the anti-inflammatory glucocorticoid dexamethasone in the induction of DUSP1 mRNA expression in activated macrophages, as well as in the inhibition of IL-6 and IL-12 production. Dexamethasone 64-77 interleukin 6 Homo sapiens 178-182 16278781-4 2005 Our data show that IGF-1, TGF-beta1, bFGF and IL-6 increase PTHrP mRNA expression and its perinuclear localization, while zoledronic acid (50 muM, 100 muM for 24 h and 48 h) and dexamethasone suppress PTHrP expression in PC-3 cells. Dexamethasone 178-191 interleukin 6 Homo sapiens 46-50 16228299-3 2005 We found that in resting cells, Tg (10-100 nM) or the bradykinin (BK) (1-10 muM) and thrombin (Thr) (1 U/ml) stimulated interleukin (IL)-6 secretion but had no effect on regulated on activation, normal T cells expressed and secreted (RANTES) levels. Thapsigargin 32-34 interleukin 6 Homo sapiens 120-138 16228299-4 2005 More importantly, such calcium-mobilizing agents significantly enhanced TNF-alpha-induced IL-6 secretion while RANTES secretion was abrogated. Calcium 23-30 interleukin 6 Homo sapiens 90-94 16228299-6 2005 The cyclic adenosine monophosphate (cAMP)-dependent pathway plays a minor role in this differential regulation of IL-6 and RANTES genes expression. Cyclic AMP 4-34 interleukin 6 Homo sapiens 114-118 16228299-6 2005 The cyclic adenosine monophosphate (cAMP)-dependent pathway plays a minor role in this differential regulation of IL-6 and RANTES genes expression. Cyclic AMP 36-40 interleukin 6 Homo sapiens 114-118 16118799-5 2005 The aims of this study were to determine the effects of statins (atorvastatin and simvastatin) on microglial cells with regard to the secretion of the inflammatory cytokine interleukin-6 (IL-6) and cell viability after activation of the cells with bacterial lipopolysaccharides (LPS) or beta-amyloid1-40 (Abeta1-40) and in unstimulated cells. Atorvastatin 65-77 interleukin 6 Homo sapiens 173-186 16118799-8 2005 Both atorvastatin and simvastatin reduced the basal secretion of IL-6 and the cell viability of the microglia, but only atorvastatin reduced LPS- and Abeta1-40-induced IL-6 secretion. Atorvastatin 5-17 interleukin 6 Homo sapiens 65-69 16118799-8 2005 Both atorvastatin and simvastatin reduced the basal secretion of IL-6 and the cell viability of the microglia, but only atorvastatin reduced LPS- and Abeta1-40-induced IL-6 secretion. Atorvastatin 120-132 interleukin 6 Homo sapiens 168-172 16273650-10 2005 A significant inverse correlation was noted between plasma IL-6 levels and cumulative nitrogen balance postoperatively in the Ala-Gln group, whereas no such correlation was observed in the Conv group. Nitrogen 86-94 interleukin 6 Homo sapiens 59-63 16273650-12 2005 However, Gln supplementation had a beneficial effect on decreasing systemic IL-6 production after surgery in patients with low admission illness severity, and lower plasma IL-6 may improve nitrogen balance in patients with abdominal surgery when Gln was administered. Nitrogen 189-197 interleukin 6 Homo sapiens 172-176 16298793-8 2005 Monocytes secreted more IL-6 when co-cultured with MF- compared to BF-spheroids. bf-spheroids 67-79 interleukin 6 Homo sapiens 24-28 16236942-7 2005 RESULTS: Dexamethasone modulated the SIRS with lower proinflammatory (IL-6, IL-8) and higher antiinflammatory (IL-10) IL levels. Dexamethasone 9-22 interleukin 6 Homo sapiens 70-74 16190914-0 2005 Inhibition of IL-6 overproduction by steroid treatment before transsternal thymectomy for myasthenia gravis: does it help stabilize perioperative condition? Steroids 37-44 interleukin 6 Homo sapiens 14-18 16190914-7 2005 Peak serum IL-6 and CRP concentrations were significantly lower in the steroid treatment group than in the non-steroid treatment group. Steroids 71-78 interleukin 6 Homo sapiens 11-15 16190914-7 2005 Peak serum IL-6 and CRP concentrations were significantly lower in the steroid treatment group than in the non-steroid treatment group. Steroids 111-118 interleukin 6 Homo sapiens 11-15 16190914-8 2005 Amongst perioperative variables subjected to multiple regression analysis, preoperative steroid treatment were found to be the most significant independent predictor of inhibited IL-6 production on postoperative day 1. Steroids 88-95 interleukin 6 Homo sapiens 179-183 16190914-10 2005 Preoperative steroid therapy can ameliorate IL-6 overproduction and may help stabilize the patient"s postoperative condition. Steroids 13-20 interleukin 6 Homo sapiens 44-48 16235156-7 2005 In addition, fasting plasma glucose was a significant determinant of adiponectin, CRP, and IL-6 plasma concentrations, whereas body fat content was only a significant predictor of CRP plasma concentration. Glucose 28-35 interleukin 6 Homo sapiens 91-95 16223437-1 2005 The objective was to investigate the relationship between homocysteine (HCY), peroxisome proliferator-activated receptors (PPAR)-gamma and the expression of interleukin 6 (IL-6) and microsomal prostaglandin E synthase (mPGES) by peripheral blood mononuclear cell (PBMC) culture in vitro, as well as to look at the intervention with HCY and PPAR-gamma activators (troglitazone and rosiglitazone). Rosiglitazone 380-393 interleukin 6 Homo sapiens 157-170 16140223-10 2005 Inhaled steroids resulted in reduced levels of IL-1 beta, IL-6, IL-8, IL-10, and IL-12 (all: P<0.01) in stable COPD (all: ex-smokers) with dose dependency for IL-8, IL-1 beta and IL-12. Steroids 8-16 interleukin 6 Homo sapiens 58-62 16011900-5 2005 Therefore, in this study, attempts were made to evaluate the activity of leukocyte arylsulphatase A, serum interleukin-6, urinary GAGs and heparan sulphate (HS) in response to tamoxifen (TAM) therapy in mastectomised breast cancer patients. Tamoxifen 176-185 interleukin 6 Homo sapiens 107-120 15890711-5 2005 Normal muscle incubated (2 h) in IL-1beta and IL-6 had increases in H2O2, PGE2, and PAF levels. Hydrogen Peroxide 68-72 interleukin 6 Homo sapiens 46-50 15940250-6 2005 Furthermore, the FGF-induced activation of ERK 1/2 contributed to the serine phosphorylation of STAT 3, suggesting that the signaling crosstalk between the cytokine receptor, IL-6 receptor alpha/gp 130 and the growth factor receptor tyrosine kinase, FGFR 3. Serine 70-76 interleukin 6 Homo sapiens 175-179 15925386-3 2005 Ethanol also significantly enhanced IL-6, TNF-alpha, and TGF-beta1 production compared with media control, but did not significantly affect the IL-1beta production. Ethanol 0-7 interleukin 6 Homo sapiens 36-40 16127269-9 2005 Release of IL-6 by activated PBMCs was higher in the low-cholesterol compared to the high-cholesterol HD patients group (p = 0.011 for post hoc test). Cholesterol 57-68 interleukin 6 Homo sapiens 11-15 16127269-9 2005 Release of IL-6 by activated PBMCs was higher in the low-cholesterol compared to the high-cholesterol HD patients group (p = 0.011 for post hoc test). Cholesterol 90-101 interleukin 6 Homo sapiens 11-15 16127269-12 2005 CONCLUSION: Production of soluble components of a crucial pro-inflammatory and potentially atherogenic cytokine, namely the IL-6, by stimulated PBMCs appears to be inversely correlated with the serum cholesterol levels in HD patients. Cholesterol 200-211 interleukin 6 Homo sapiens 124-128 15894558-5 2005 In this study, we show that IL-6 stimulates a transient increase of tyrosine phosphorylation of STAT3 in a dose-dependent fashion. Tyrosine 68-76 interleukin 6 Homo sapiens 28-32 16135414-1 2005 The purpose of the present study was to investigate the ability of high-density lipoproteins (HDL) to attenuate endothelial dysfunction, by assessing down-regulation of cytokine-induced interleukin-6 (IL-6) production in cultured endothelial cells, and measuring plasma IL-6 levels in three groups of healthy individuals with low, average, or high plasma HDL-cholesterol. Cholesterol 359-370 interleukin 6 Homo sapiens 186-199 16135414-1 2005 The purpose of the present study was to investigate the ability of high-density lipoproteins (HDL) to attenuate endothelial dysfunction, by assessing down-regulation of cytokine-induced interleukin-6 (IL-6) production in cultured endothelial cells, and measuring plasma IL-6 levels in three groups of healthy individuals with low, average, or high plasma HDL-cholesterol. Cholesterol 359-370 interleukin 6 Homo sapiens 201-205 16135414-5 2005 The median plasma IL-6 concentration was significantly higher in subjects with low HDL-cholesterol (2.54 pg/ml) compared with those with average or high HDL-cholesterol (1.31 pg/ml and 1.47 pg/ml, respectively). Cholesterol 87-98 interleukin 6 Homo sapiens 18-22 16135414-6 2005 When all subjects were considered together, a lower HDL-cholesterol was the strongest independent predictor of higher IL-6 (F=25.38, P<0.001). Cholesterol 56-67 interleukin 6 Homo sapiens 118-122 15890711-5 2005 Normal muscle incubated (2 h) in IL-1beta and IL-6 had increases in H2O2, PGE2, and PAF levels. Dinoprostone 74-78 interleukin 6 Homo sapiens 46-50 15890711-11 2005 IL-6 causes production of H2O2, PAF, and other unidentified inflammatory mediators. Hydrogen Peroxide 26-30 interleukin 6 Homo sapiens 0-4 16137286-0 2005 Interleukin-6 modulates plasma cholesterol and C-reactive protein concentrations in nonagenarians. Cholesterol 31-42 interleukin 6 Homo sapiens 0-13 15886319-5 2005 IL-6 was dramatically induced within 3 hours after injection, and urinary hepcidin peaked within 6 hours, followed by a significant decrease in serum iron. Iron 150-154 interleukin 6 Homo sapiens 0-4 15886319-7 2005 These in vivo human results confirm the importance of the IL-6-hepcidin axis in the development of hypoferremia in inflammation and highlight the rapid responsiveness of this iron regulatory system. Iron 175-179 interleukin 6 Homo sapiens 58-62 15913932-7 2005 Increased IL-6 production was partially inhibited by treatment of iron (HIF-1 inhibitor) or pyrriolidine-dithiocarbamate (PDTC, NF-kappaB inhibitor). Iron 66-70 interleukin 6 Homo sapiens 10-14 16323060-0 2005 Vitamin D, tamoxifen and beta-estradiol modulate breast cancer cell growth and interleukin-6 and metalloproteinase-2 production in three-dimensional co-cultures of tumor cell spheroids with endothelium. Vitamin D 0-9 interleukin 6 Homo sapiens 79-92 16323060-0 2005 Vitamin D, tamoxifen and beta-estradiol modulate breast cancer cell growth and interleukin-6 and metalloproteinase-2 production in three-dimensional co-cultures of tumor cell spheroids with endothelium. Tamoxifen 11-20 interleukin 6 Homo sapiens 79-92 16323060-0 2005 Vitamin D, tamoxifen and beta-estradiol modulate breast cancer cell growth and interleukin-6 and metalloproteinase-2 production in three-dimensional co-cultures of tumor cell spheroids with endothelium. Estradiol 25-39 interleukin 6 Homo sapiens 79-92 16323060-4 2005 The study was also designed to investigate whether vitamin D might influence interleukin-6 (IL-6) and metalloproteinase-2 (MMP-2) production in a co-culture of T47D cell spheroids with an endothelial cell monolayer in the presence of beta-estradiol and TAM. Vitamin D 51-60 interleukin 6 Homo sapiens 77-90 16323060-4 2005 The study was also designed to investigate whether vitamin D might influence interleukin-6 (IL-6) and metalloproteinase-2 (MMP-2) production in a co-culture of T47D cell spheroids with an endothelial cell monolayer in the presence of beta-estradiol and TAM. Vitamin D 51-60 interleukin 6 Homo sapiens 92-96 16323060-7 2005 Direct contact of tumor cell spheroids with the endothelium induced production of MMP-2 and IL-6, which was significantly inhibited in TAM/beta-estradiol balanced medium. Tamoxifen 135-138 interleukin 6 Homo sapiens 92-96 16323060-7 2005 Direct contact of tumor cell spheroids with the endothelium induced production of MMP-2 and IL-6, which was significantly inhibited in TAM/beta-estradiol balanced medium. Estradiol 139-153 interleukin 6 Homo sapiens 92-96 16323060-8 2005 Addition of vitamin D further inhibited MMP-2 production, but enhanced the production of IL-6 as was shown by ELISA assay. Vitamin D 12-21 interleukin 6 Homo sapiens 89-93 16137286-9 2005 CONCLUSION: The relationship between IL-6 and plasma CRP and cholesterol levels in nonagenarians with enhanced systemic inflammation differs from that of middle-aged subjects. Cholesterol 61-72 interleukin 6 Homo sapiens 37-41 16123700-2 2005 As revealed by ELISA, capsaicin induced IL-6 expression in PF-10 cells, and the VR1 antagonist capsazepine dose-dependently inhibited capsaicin-induced IL-6 production, indicating that capsaicin-induced IL-6 expression is related to VR1 activation. Capsaicin 22-31 interleukin 6 Homo sapiens 40-44 16123700-2 2005 As revealed by ELISA, capsaicin induced IL-6 expression in PF-10 cells, and the VR1 antagonist capsazepine dose-dependently inhibited capsaicin-induced IL-6 production, indicating that capsaicin-induced IL-6 expression is related to VR1 activation. Capsaicin 134-143 interleukin 6 Homo sapiens 152-156 16123700-2 2005 As revealed by ELISA, capsaicin induced IL-6 expression in PF-10 cells, and the VR1 antagonist capsazepine dose-dependently inhibited capsaicin-induced IL-6 production, indicating that capsaicin-induced IL-6 expression is related to VR1 activation. Capsaicin 134-143 interleukin 6 Homo sapiens 152-156 16123700-2 2005 As revealed by ELISA, capsaicin induced IL-6 expression in PF-10 cells, and the VR1 antagonist capsazepine dose-dependently inhibited capsaicin-induced IL-6 production, indicating that capsaicin-induced IL-6 expression is related to VR1 activation. Capsaicin 134-143 interleukin 6 Homo sapiens 152-156 16123700-5 2005 p38 MAPK is involved in capsaicin-induced IL-6 production, as shown by the use of specific inhibitors of this kinase. Capsaicin 24-33 interleukin 6 Homo sapiens 42-46 16123706-5 2005 The aim of this study was to investigate the effects of root canal sealers N2 (zinc-oxide eugenol based) and AH Plus (epoxy resin based) on the expression of IL-6 and IL-8 mRNA gene in human osteoblastic cell line U2OS cells. Nitrogen 75-77 interleukin 6 Homo sapiens 158-162 16123700-2 2005 As revealed by ELISA, capsaicin induced IL-6 expression in PF-10 cells, and the VR1 antagonist capsazepine dose-dependently inhibited capsaicin-induced IL-6 production, indicating that capsaicin-induced IL-6 expression is related to VR1 activation. Capsaicin 134-143 interleukin 6 Homo sapiens 152-156 16130198-14 2005 Correlation analysis showed that FT (free testosterone) had negative correlation with CRP, IL-6 and sICAM-1. Testosterone 42-54 interleukin 6 Homo sapiens 91-95 15965659-2 2005 METHODS: We tested for associations between the -174 IL-6 G/C promoter polymorphism and fasting plasma glucose (FPG) and type 2 diabetes in a sample of 1,428 individuals from the largest 182 families in the National Heart, Lung and Blood Institute"s Framingham Heart Study population. Glucose 103-110 interleukin 6 Homo sapiens 53-57 15967875-4 2005 A TP agonist, 9,11-dideoxy-9alpha,11alpha-methanoepoxy-prosta-5Z,13E-dien-1-oic acid (U46619), enhanced IL-6 production in both 1321N1 cells and cultured mouse astrocytes. 9,11-dideoxy-9alpha 14-33 interleukin 6 Homo sapiens 104-108 15967875-4 2005 A TP agonist, 9,11-dideoxy-9alpha,11alpha-methanoepoxy-prosta-5Z,13E-dien-1-oic acid (U46619), enhanced IL-6 production in both 1321N1 cells and cultured mouse astrocytes. 11alpha-methanoepoxy-prosta-5z,13e-dien-1-oic acid 34-84 interleukin 6 Homo sapiens 104-108 15967875-7 2005 Although U46619 increased IL-6 promoter activity, a mutation at cyclic AMP-response element (CRE) on the promoter clearly suppressed the effect, suggesting that CRE is involved in U46619-induced IL-6 expression. Cyclic AMP 64-74 interleukin 6 Homo sapiens 195-199 16086584-10 2005 Finally, MadA, but not the HFI portion, inhibits IL-6-dependent Stat3 tyrosine phosphorylation in HepG2 cells. Tyrosine 70-78 interleukin 6 Homo sapiens 49-53 16003000-8 2005 Furthermore, in the presence of U0126 and PD-98059, selective inhibitors of MEK1/2, IL-17-induced IL-6 production was significantly attenuated. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 42-50 interleukin 6 Homo sapiens 98-102 16164430-7 2005 Significant positive correlation was observed between the IL-6 and ROS levels in vasectomy reversal patients compared with donors (r = 0.41, P = 0.05 versus r = 0.38, P = 0.15). Reactive Oxygen Species 67-70 interleukin 6 Homo sapiens 58-62 15801904-13 2005 In accordance with this finding, IL-6 correlated positively (r = 0.74, P < 0.001) with fibrinogen, but negatively (r = -0.46, P = 0.016) with total cholesterol concentration. Cholesterol 151-162 interleukin 6 Homo sapiens 33-37 16204423-8 2005 This was manifest by disparities in interleukin-6 and tumor necrosis factor-alpha production in the presence of dexamethasone. Dexamethasone 112-125 interleukin 6 Homo sapiens 36-81 16009562-8 2005 Only dexamethasone caused an inhibition of IL-6 production. Dexamethasone 5-18 interleukin 6 Homo sapiens 43-47 15912140-6 2005 Release of IL-6, IL-8 and TNF-alpha was inhibited by 82-93% at 100 microM quercetin and kaempferol, and 31-70% by myricetin and morin. myricetin 114-123 interleukin 6 Homo sapiens 11-15 16096442-9 2005 On day 1, HDL cholesterol levels correlated inversely with interleukin-6 (r = -0.72; p < .01) and tumor necrosis factor (TNF)-alpha (r = -0.70; p < .01) concentrations. Cholesterol 14-25 interleukin 6 Homo sapiens 59-72 16079075-11 2005 Among the elements in the first factor, Fe and Si correlated with IL-6 release, whereas Cr correlated with IL-8 release. Iron 40-42 interleukin 6 Homo sapiens 66-70 16200844-13 2005 Furthermore, IGFBP-1 and IL-6 increase steeply, presumably aimed at diminishing insulin-like activity of IGF-I, thereby reducing peripheral glucose utilization. Glucose 140-147 interleukin 6 Homo sapiens 25-29 15950746-8 2005 Interestingly, activation of DC-Dexa with a specific TLR2 ligand induced a strong up-regulation of IL-10 along with TNF-alpha and IL-6, a combination of cytokines that allow amplification of regulatory DC populations. dc-dexa 29-36 interleukin 6 Homo sapiens 130-134 15943769-4 2005 The production of vascular endothelial growth factor (VEGF), interleukin (IL)-6 and IL-8 by HGF increased following stimulation with estradiol or progesterone, at concentrations comparable to those present in the plasma of pregnant women. Estradiol 133-142 interleukin 6 Homo sapiens 61-79 15943769-4 2005 The production of vascular endothelial growth factor (VEGF), interleukin (IL)-6 and IL-8 by HGF increased following stimulation with estradiol or progesterone, at concentrations comparable to those present in the plasma of pregnant women. Progesterone 146-158 interleukin 6 Homo sapiens 61-79 15802527-6 2005 Although interleukin 6 (IL-6) and insulin-like growth factor-1 (IGF-1) abrogate Dex-induced MM cell cytotoxicity, neither IL-6 nor IGF-1 protects against R-etodolac-induced cytotoxicity in MM cells. Dexamethasone 80-83 interleukin 6 Homo sapiens 9-22 15802527-6 2005 Although interleukin 6 (IL-6) and insulin-like growth factor-1 (IGF-1) abrogate Dex-induced MM cell cytotoxicity, neither IL-6 nor IGF-1 protects against R-etodolac-induced cytotoxicity in MM cells. Dexamethasone 80-83 interleukin 6 Homo sapiens 24-28 15878941-4 2005 After ARVM were exposed to IL-6 for 2-24 h, intracellular cGMP contents were time dependently increased; this was mimicked by a NO donor and abolished by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), an inhibitor of soluble guanylyl cyclase (sGC), or Rp-8-Br-cGMP, an inhibitor of cGMP-dependent protein kinase G (PKG). Cyclic GMP 58-62 interleukin 6 Homo sapiens 27-31 16024627-5 2005 In the human multiple myeloma cell line IM-9, an autocrine IL-6 loop exists, which enables the cell to resist the effects of dexamethasone, a common treatment for multiple myeloma. Dexamethasone 125-138 interleukin 6 Homo sapiens 59-63 15769938-11 2005 Furthermore, sirolimus significantly inhibited inflammatory cytokines IL-6 and TNF-alpha production in macrophages. Sirolimus 13-22 interleukin 6 Homo sapiens 70-74 16253163-1 2005 OBJECTIVE: To develop an oligonucleotide array for single nucleotide polymorphism (SNP) typing of cytokines, such as tumor necrosis factor (TNF)-a, interleukin (IL)-10, tumor growth factor (TGF)-betal, IL-4, and IL-6, and their receptors and evaluate its function by direct sequencing. Oligonucleotides 25-40 interleukin 6 Homo sapiens 212-216 15741245-1 2005 The present study examined the role of the cytokine IL-6 in the regulation of fatty acid metabolism during exercise in humans. Fatty Acids 78-88 interleukin 6 Homo sapiens 52-56 16002736-7 2005 Dexamethasone completely blocked the effect of IL-1beta on IL-6 expression. Dexamethasone 0-13 interleukin 6 Homo sapiens 59-63 15979442-3 2005 hs-CRP (0.10 < or = r(2) < or =0.37) and IL-6 (0.06 < or = r(2) < or =0.31) were significantly associated with anthropometric and metabolic variables, including visceral and subcutaneous adipose tissue, systolic and diastolic blood pressure, triglycerides, high-density lipoprotein (HDL) cholesterol, and insulin sensitivity (p <0.05). Triglycerides 254-267 interleukin 6 Homo sapiens 47-51 15979442-3 2005 hs-CRP (0.10 < or = r(2) < or =0.37) and IL-6 (0.06 < or = r(2) < or =0.31) were significantly associated with anthropometric and metabolic variables, including visceral and subcutaneous adipose tissue, systolic and diastolic blood pressure, triglycerides, high-density lipoprotein (HDL) cholesterol, and insulin sensitivity (p <0.05). Cholesterol 300-311 interleukin 6 Homo sapiens 47-51 15929761-7 2005 Ethanol consumption correlated significantly with antiadduct IgA and IL-6 levels, which also showed parallel changes upon abstinence. Ethanol 0-7 interleukin 6 Homo sapiens 69-73 15790728-0 2005 Extracellular adenosine 5"-triphosphate modulates interleukin-6 production by human thyrocytes through functional purinergic P2 receptors. Adenosine Triphosphate 14-39 interleukin 6 Homo sapiens 50-63 15790728-6 2005 The ATP-hydrolyzing enzyme apyrase reduced basal IL-6 release, whereas extracellular ATP dose-dependently increased IL-6 secretion. Adenosine Triphosphate 4-7 interleukin 6 Homo sapiens 49-53 16029943-5 2005 Furthermore, subjects with Ala variant had significantly lower IL-6 levels (0.88 +/- 0.9 vs 1.61 +/- 2.25 pg/ml; p = 0.041). Alanine 27-30 interleukin 6 Homo sapiens 63-67 16003055-9 2005 A dose of hydrocortisone (4 microg/kg/min for 6 hrs) that maintained plasma cortisol between 40 and 50 microg/dL, starting 60-90 mins before surgery, significantly suppressed plasma interleukin-6 after surgery compared with control while significantly increasing plasma interleukin-10 during surgery. Hydrocortisone 10-24 interleukin 6 Homo sapiens 182-195 16003055-11 2005 CONCLUSIONS: At the doses studied, cortisol-induced suppression of plasma interleukin-6 during and after cardiac surgery appears to be a saturable phenomenon at the concentration of plasma cortisol that is normally achieved after surgery in untreated patients. Hydrocortisone 35-43 interleukin 6 Homo sapiens 74-87 16130848-7 2005 Immune modification using local steroids and disease-modifying antirheumatic drugs, such as hydroxychloroquine, are known to inhibit inflammatory cells and cytokines, such as interleukin-1, interleukin-6 and tumor necrosis factor, which are responsible for pain and tissue damage. Steroids 32-40 interleukin 6 Homo sapiens 190-203 16022097-9 2005 Whereas lactate-incubated cells did not respond to IL-1beta stimulation, bicarbonate/lactate-treated cells adequately increased IL-6 release after stimulation (p < 0.0005). Bicarbonates 73-84 interleukin 6 Homo sapiens 128-132 16022097-9 2005 Whereas lactate-incubated cells did not respond to IL-1beta stimulation, bicarbonate/lactate-treated cells adequately increased IL-6 release after stimulation (p < 0.0005). Lactic Acid 85-92 interleukin 6 Homo sapiens 128-132 15826936-0 2005 Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. Cholesterol 5-16 interleukin 6 Homo sapiens 94-107 15826936-2 2005 Herein we show that FC accumulation in macrophages leads to the induction and secretion of two inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). Fc(alpha) receptor 20-22 interleukin 6 Homo sapiens 163-176 15826936-2 2005 Herein we show that FC accumulation in macrophages leads to the induction and secretion of two inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). Fc(alpha) receptor 20-22 interleukin 6 Homo sapiens 178-182 15940151-9 2005 Further, CBMCs from children with mothers with allergy had a lower ( P = .03) IL-6 response after stimulation with peptidoglycan than CBMCs from children with mothers without allergy. cbmcs 9-14 interleukin 6 Homo sapiens 78-82 15984600-9 2005 CONCLUSIONS: These findings suggest that high doses of montelukast modulate the production of IL-6, TNF-alpha, and MCP-1 through the inhibition of NF-kappaB activation. montelukast 55-66 interleukin 6 Homo sapiens 94-98 15930364-9 2005 Taken together, these results indicate that inhibition of IL-6 signaling by Sant7 significantly potentiates the therapeutic action of dexamethasone against multiple myeloma cells, providing the preclinical rationale for clinical trials of Sant7 in combination with dexamethasone to improve patient outcome in multiple myeloma. Dexamethasone 134-147 interleukin 6 Homo sapiens 58-62 15930364-9 2005 Taken together, these results indicate that inhibition of IL-6 signaling by Sant7 significantly potentiates the therapeutic action of dexamethasone against multiple myeloma cells, providing the preclinical rationale for clinical trials of Sant7 in combination with dexamethasone to improve patient outcome in multiple myeloma. Dexamethasone 265-278 interleukin 6 Homo sapiens 58-62 15984600-7 2005 Furthermore, 10(-5)M montelukast significantly inhibited lipopolysaccharide-induced IL-6, TNF-alpha, and MCP-1 production in the peripheral blood mononuclear cells of controls and patients with asthma. montelukast 21-32 interleukin 6 Homo sapiens 84-88 15934951-0 2005 Lactate induces tumour necrosis factor-alpha, interleukin-6 and interleukin-1beta release in microglial- and astroglial-enriched primary cultures. Lactic Acid 0-7 interleukin 6 Homo sapiens 46-59 15934951-9 2005 Lactate, but not NH4Cl, induced release of TNF-alpha and IL-6 in both astroglial- and microglial-enriched cultures, while IL-1beta was released only in microglial cultures. Lactic Acid 0-7 interleukin 6 Homo sapiens 57-61 15811432-7 2005 Moreover, some genes, such as VDR and IL-6, were shown to interact with non-genetic factors, i.e. calcium intake and estrogens, to modulate BMD. Calcium 98-105 interleukin 6 Homo sapiens 38-42 16008970-11 2005 IL-6 level in EBC was correlated positively with AHI (r = 0.441, P < 0.05), ODI(4) (r = 0.533, P < 0.05), and negatively with minimal oxygen saturation (r = -0.529, P < 0.05). Oxygen 140-146 interleukin 6 Homo sapiens 0-4 15836614-0 2005 Serotonin via 5-HT7 receptors activates p38 mitogen-activated protein kinase and protein kinase C epsilon resulting in interleukin-6 synthesis in human U373 MG astrocytoma cells. Serotonin 0-9 interleukin 6 Homo sapiens 119-132 15843537-4 2005 The results presented in this study demonstrate that the saturated fatty acid, lauric acid, up-regulates the expression of costimulatory molecules (CD40, CD80, and CD86), MHC class II, and cytokines (IL-12p70 and IL-6) in bone marrow-derived DCs. Fatty Acids 57-77 interleukin 6 Homo sapiens 213-217 15867169-8 2005 High-fat load and glucose alone produced a decrease in endothelial function and increases in nitrotyrosine, C-reactive protein, intercellular adhesion molecule-1, and interleukin-6. Glucose 18-25 interleukin 6 Homo sapiens 167-180 15867183-3 2005 METHODS AND RESULTS: In cultured cardiac myocytes, specific activation of stress-activated mitogen-activated protein kinase, p38, by upstream activator MKK6bE led to significant induction of tumor necrosis factor-alpha and interleukin-6 secretion, whereas treating cells with a selective p38 inhibitor (SB239068) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation. sb239068 303-311 interleukin 6 Homo sapiens 223-236 15613495-4 2005 Although depletion of intra- or extracellular Ca(2+) pool using thapsigargin (TG) or EGTA, respectively, showed little effect, a TG-EGTA mixture significantly inhibited stretch-induced IKK activation and IL-6 secretion. Thapsigargin 129-131 interleukin 6 Homo sapiens 204-208 15613495-4 2005 Although depletion of intra- or extracellular Ca(2+) pool using thapsigargin (TG) or EGTA, respectively, showed little effect, a TG-EGTA mixture significantly inhibited stretch-induced IKK activation and IL-6 secretion. Egtazic Acid 132-136 interleukin 6 Homo sapiens 204-208 15836614-8 2005 5-HT-induced IL-6 synthesis is inhibited by the partially selective 5-HT7 receptor antagonist, pimozide, and the selective antagonist SB269970. Pimozide 95-103 interleukin 6 Homo sapiens 13-17 15836625-5 2005 This study was undertaken to determine whether PGE2 is involved in the up-regulation of IL-6 in invading macrophages. Dinoprostone 47-51 interleukin 6 Homo sapiens 88-92 15836614-9 2005 Furthermore, IL-6 synthesis was induced by the 5-HT7 receptor agonist carboxamidotryptamin. carboxamidotryptamin 70-90 interleukin 6 Homo sapiens 13-17 15836625-11 2005 Treatment with PGE2 further enhanced IL-6 release in a concentration- and time-dependent manner. Dinoprostone 15-19 interleukin 6 Homo sapiens 37-41 15836625-14 2005 Taken together, our data suggest that PGE2 is involved in mediating the up-regulation of IL-6 occurring in invading macrophages. Dinoprostone 38-42 interleukin 6 Homo sapiens 89-93 15769552-0 2005 IL-6 expression induced by adenosine A2b receptor stimulation in U373 MG cells depends on p38 mitogen activated kinase and protein kinase C. Adenosine binds to a class of G-protein coupled receptors, which are further distinguished as A(1), A(2a), A(2b) and A(3) adenosine receptors. Adenosine 141-150 interleukin 6 Homo sapiens 0-4 15769552-1 2005 As we have shown earlier, the stable adenosine analogue NECA (N6-(R)-phenylisopropyladenosine) stimulates IL-6 expression in the human astrocytoma cell line U373 MG via the A(2b) receptor. Adenosine 37-46 interleukin 6 Homo sapiens 106-110 15833109-1 2005 Calcium-sensitive fluorescence microscopy and molecular biology analysis have been used to study the effects of platelet-activating factor (PAF) on intracellular calcium [Ca2+]i and IL-6 expression in human microglia. Calcium 0-7 interleukin 6 Homo sapiens 182-186 15892984-0 2005 Effects of serotonin and serotonergic agonists and antagonists on the production of tumor necrosis factor alpha and interleukin-6. Serotonin 11-20 interleukin 6 Homo sapiens 116-129 15892984-5 2005 We found that: (1) 5-HT, 15 microg/ml, significantly decreased IL-6 and TNFalpha production; (2) pCPA, 5 microM, significantly suppressed the production of IL-6 and TNFalpha; and (3) mCPP, 2.7 microg/ml, significantly increased the production of IL-6 and TNFalpha. Fenclonine 97-101 interleukin 6 Homo sapiens 156-160 15892984-5 2005 We found that: (1) 5-HT, 15 microg/ml, significantly decreased IL-6 and TNFalpha production; (2) pCPA, 5 microM, significantly suppressed the production of IL-6 and TNFalpha; and (3) mCPP, 2.7 microg/ml, significantly increased the production of IL-6 and TNFalpha. Fenclonine 97-101 interleukin 6 Homo sapiens 156-160 15946602-12 2005 In addition, GBIT extract inhibited phorbol 12-myristate 13-acetate + A23187-induced interleukin-6 secretion from human mast cell line HMC-1 cells. Tetradecanoylphorbol Acetate 36-67 interleukin 6 Homo sapiens 85-98 15714504-6 2005 A significant reduction in IL-6 secretion was also observed with the other silicate- and zinc phosphate-based glasses tested. Silicates 75-83 interleukin 6 Homo sapiens 27-31 15763541-4 2005 ASA blocked the expression of cyclooxygenase-2, the production of tumor necrosis factor-alpha and interleukin-6, and the release of granule mediators from mast cells in a concentration-dependent fashion. Aspirin 0-3 interleukin 6 Homo sapiens 98-111 15618359-11 2005 PGE(2) stimulated IL-6 secretion by bone cells, whereas COX-2 inhibitors decreased this same parameter. Dinoprostone 0-6 interleukin 6 Homo sapiens 18-22 15661740-9 2005 Increased TGF-beta1-dependent Smad signaling by IL-6 was significantly attenuated by inhibition of clathrin-mediated endocytosis and augmented by depletion of membrane cholesterol. Cholesterol 168-179 interleukin 6 Homo sapiens 48-52 15714504-8 2005 TNF-alpha and IL-6 secretion from stimulated cells was lower in presence of the silicate glasses compared with the zinc phosphate glasses, indicating that this system of bioactive glass might be of clinical use in conditions associated with inflammation. Silicates 80-88 interleukin 6 Homo sapiens 14-18 15983630-3 2005 In particular, 17 beta-estradiol (E2) in patients with systemic inflammatory diseases leads to an higher production of IgG and IgM in peripheral blood mononucleated cells (PBMC) and the secretion of metalloproteinases and IL-6 by synovial fibroblasts. Estradiol 15-32 interleukin 6 Homo sapiens 222-226 15790923-13 2005 On calcium-induced dissociation, bFGF, IL-6, matrix metalloproteinase (MMP)-1, and placental growth factor (PlGF) were upregulated, whereas acidic (a)FGF and pigment epithelium-derived factor (PEDF) were both downregulated. Calcium 3-10 interleukin 6 Homo sapiens 39-43 15801793-3 2005 A series of flask cultures were conducted in LB medium at 37 degrees C. The intact hIL-6 was expressed mostly in the form of inclusion body. lb medium 45-54 interleukin 6 Homo sapiens 83-88 15764709-0 2005 STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation. Serine 120-123 interleukin 6 Homo sapiens 67-71 15764709-3 2005 In IL-6 signaling, the two major pathways that derive from the YXXQ and the YSTV motifs of gp130 cause Ser-727 phosphorylation. Serine 103-106 interleukin 6 Homo sapiens 3-7 15838561-9 2005 Patients treated with carvedilol had a significant improvement in functional class compared with the baseline values (P=0.001), with a decrease in the levels of cytokines (IL-6 [P=0.001] and TNF-a [P=0.001]). Carvedilol 22-32 interleukin 6 Homo sapiens 172-176 15764709-4 2005 Here, we show that TGF-beta-activated kinase 1 (TAK1) interacts with STAT3, that the TAK1-Nemo-like kinase (NLK) pathway is efficiently activated by IL-6 through the YXXQ motif, and that this is the YXXQ-mediated H7-sensitive pathway that leads to STAT3 Ser-727 phosphorylation. Serine 254-257 interleukin 6 Homo sapiens 149-153 15755997-11 2005 CONCLUSIONS: Significant correlations were found between serum levels of TGF-alpha and IL-6, circadian patterns in wrist activity and serum cortisol and tumor-related symptoms in patients with metastatic colorectal cancer. Hydrocortisone 140-148 interleukin 6 Homo sapiens 87-91 15719372-3 2005 The purpose of the present study was to determine the effects of ATP on TNF-alpha, IL-6 and IL-10 release in stimulated whole blood. Adenosine Triphosphate 65-68 interleukin 6 Homo sapiens 83-87 15542570-3 2005 In the context of skeletal muscle, IL-6 has variously been reported to regulate carbohydrate and lipid metabolism, increase satellite cell proliferation, or cause muscle wasting. Carbohydrates 80-92 interleukin 6 Homo sapiens 35-39 15883744-0 2005 Retinoic acid inhibits CD40 plus IL-4 mediated IgE production through alterations of sCD23, sCD54 and IL-6 production. Tretinoin 0-13 interleukin 6 Homo sapiens 102-106 15883744-10 2005 Cytokine analysis showed that IL-6 secretion was significantly inhibited by ATRA (53.6 +/- 0.6%) and also IL-6 mRNA synthesis was reduced (66.3 +/- 11.6%). Tretinoin 76-80 interleukin 6 Homo sapiens 30-34 15883744-11 2005 The observed inhibition of IgE production mediated by ATRA was significantly reversed to 90.5 +/- 12% by the addition of 100 pg/mL recombinant IL-6. Tretinoin 54-58 interleukin 6 Homo sapiens 143-147 15728480-5 2005 Cyclosporin A and FK506, which target calcineurin and thereby inhibit TCR-mediated Ca(2+) signal pathways, block IL-6-mediated c-Maf expression. Cyclosporine 0-13 interleukin 6 Homo sapiens 113-117 15883744-12 2005 CONCLUSIONS: ATRA interferes through several pathways with the anti-CD40 plus IL-4 mediated B cell activation, namely IL-6, CD23 and CD54. Tretinoin 13-17 interleukin 6 Homo sapiens 118-122 15613416-6 2005 In multivariate analysis, the association between DC and visceral fat disappeared after adjustment for CRP and IL-6. Deoxycytidine 50-52 interleukin 6 Homo sapiens 111-115 15796767-9 2005 The LPS-induced IL-6 production was blocked by the specific p38alphaMAP kinase inhibitor, SB203580, and by the synthetic glucocorticoid, dexamethasone. Dexamethasone 137-150 interleukin 6 Homo sapiens 16-20 15795476-15 2005 Plasma IL-6 concentration at rest in fed subjects was negatively correlated with plasma ghrelin concentration (r = -0.73, p < 0.05) and positively correlated with plasma insulin concentration (r = 0.78, p < 0.05). Ghrelin 88-95 interleukin 6 Homo sapiens 7-11 15795476-19 2005 Moreover we believe, that the fasting-induced significant increase in plasma IL-6 concentration at rest, accompanied by higher plasma norepinephrine concentration and lower RQ, belongs to the physiological responses, maintaining energy homeostasis in the fasting state. Norepinephrine 134-148 interleukin 6 Homo sapiens 77-81 16895664-4 2005 Calcineurin inhibitors, cyclosporine and tacrolimus, are involved in tumor development through various mechanisms: they promote B-cell proliferation by increasing T lymphocyte IL6 secretion, decrease DNA repair ability and may be able to promote metastasis spreading by a direct cellular effect that is independent of their effect on the host"s immune cells. Cyclosporine 24-36 interleukin 6 Homo sapiens 176-179 15652235-5 2005 Histamine induced concentration- and time-dependent production of granulocyte-macrophage-colony stimulating factor (GM-CSF), interleukin (IL)-8 and IL-6, which was completely blocked by olopatadine, an H1 antagonist. Histamine 0-9 interleukin 6 Homo sapiens 148-152 15663961-0 2005 Interleukin-6 protects cultured cerebellar granule neurons against glutamate-induced neurotoxicity. Glutamic Acid 67-76 interleukin 6 Homo sapiens 0-13 15663961-3 2005 In the present study, we explored protective effect of IL-6 that was chronically applied to cerebellar granule neurons (CGNs) in culture against neurodamage induced by glutamate and mechanisms involved in the neuroprotective effect of IL-6. Glutamic Acid 168-177 interleukin 6 Homo sapiens 55-59 15663961-4 2005 The chronic IL-6 exposure significantly prevented the CGNs from the glutamate-induced attenuation of neuronal vitality. Glutamic Acid 68-77 interleukin 6 Homo sapiens 12-16 15663961-7 2005 The glutamate-evoked neuronal apoptosis also was strikingly inhibited by the chronic IL-6 pretreatment. Glutamic Acid 4-13 interleukin 6 Homo sapiens 85-89 15663961-9 2005 Although intracellular Ca2+ in the IL-6-pretreated CGNs also produced an acute and transient elevation in response to the glutamate insult, they quickly dropped and recovered to basal levels before the glutamate application. Glutamic Acid 122-131 interleukin 6 Homo sapiens 35-39 15663961-9 2005 Although intracellular Ca2+ in the IL-6-pretreated CGNs also produced an acute and transient elevation in response to the glutamate insult, they quickly dropped and recovered to basal levels before the glutamate application. Glutamic Acid 202-211 interleukin 6 Homo sapiens 35-39 15663961-10 2005 Anti-gp130 monoclonal antibody (mAb) blocked the suppressive effect of IL-6 on the glutamate-induced intracellular Ca2+ overload. Glutamic Acid 83-92 interleukin 6 Homo sapiens 71-75 15663961-11 2005 These results reveal that IL-6 can protect neurons against glutamate-induced neurotoxicity, and suggest that the neuroprotective effect of IL-6 may be via gp130 signal transducing pathway to suppress the glutamate-evoked intracellular Ca2+ overload. Glutamic Acid 59-68 interleukin 6 Homo sapiens 26-30 15663961-11 2005 These results reveal that IL-6 can protect neurons against glutamate-induced neurotoxicity, and suggest that the neuroprotective effect of IL-6 may be via gp130 signal transducing pathway to suppress the glutamate-evoked intracellular Ca2+ overload. Glutamic Acid 59-68 interleukin 6 Homo sapiens 139-143 15663961-11 2005 These results reveal that IL-6 can protect neurons against glutamate-induced neurotoxicity, and suggest that the neuroprotective effect of IL-6 may be via gp130 signal transducing pathway to suppress the glutamate-evoked intracellular Ca2+ overload. Glutamic Acid 204-213 interleukin 6 Homo sapiens 26-30 15663961-11 2005 These results reveal that IL-6 can protect neurons against glutamate-induced neurotoxicity, and suggest that the neuroprotective effect of IL-6 may be via gp130 signal transducing pathway to suppress the glutamate-evoked intracellular Ca2+ overload. Glutamic Acid 204-213 interleukin 6 Homo sapiens 139-143 15652280-5 2005 When CYSST (1mg/ml) was added, the production of tumor necrosis factor-alpha, interleukin (IL)-6, and IL-8 was significantly inhibited about 37, 33.6, and 48%, respectively on phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated HMC-1 cells. Tetradecanoylphorbol Acetate 176-207 interleukin 6 Homo sapiens 78-96 15750272-6 2005 After steroid therapy was restarted, there were improvements in her audibility, radial arterial pulsation, and levels of inflammatory markers (erythrocyte sedimentation rate, C-reactive protein, and gamma-globulin), fibrinogen, interleukin-6, and RANTES (regulated on activation, normal T cell expressed and secreted). Steroids 6-13 interleukin 6 Homo sapiens 228-241 15750714-9 2005 CONCLUSIONS: The present data indicate the differential regulation by DLE of the production of TNFalpha, IL-6, and IL-8 cytokines, associated with effects on TLR2 and TLR4 expression and NF-kappaB and cAMP activities. Cyclic AMP 201-205 interleukin 6 Homo sapiens 105-109 15693092-11 2005 TNF-a induced increases in IL-6, IL-8, and COX-2 mRNA were suppressed by dexamethasone in both fd-FLS and td-FLS. Dexamethasone 73-86 interleukin 6 Homo sapiens 27-31 15630592-5 2005 We show that recombinant glucocorticoid receptor (GR) binds strongly to the AGT gene promoter when nucleoside A is present at -217, and dexamethasone treatment increases the interleukin 6 induced promoter activity of reporter constructs containing nucleoside A at -217. Dexamethasone 136-149 interleukin 6 Homo sapiens 174-187 15725747-5 2005 Neonates exposed to nicotine during gestation showed a significant decrease in the number of bone marrow hematopoietic progenitors, as measured by colony-forming unit (CFU) and long-term culture initiating cell (LTC-IC) assays, and decreased concentration of interleukin-6 (IL-6) in their serum. Nicotine 20-28 interleukin 6 Homo sapiens 259-272 15683451-6 2005 The lymph node homing chemokine receptor CCR-7 expression was induced by TNF-alpha + IL-1beta + IL-6 + prostaglandin E2 but was not induced by Poly I:C + TNF-alpha. Dinoprostone 103-119 interleukin 6 Homo sapiens 96-100 15871192-9 2005 The IL-6 levels had significant differences between patients with the normal serum CRP, serum calcium, and beta2-MG and patients with abnormal ones (P < 0.05). Calcium 94-101 interleukin 6 Homo sapiens 4-8 15665187-11 2005 Moreover, this kinase becomes phosphorylated on tyrosine residues upon sperm treatment with recombinant IL-6, which suggests its activation by the cytokine. Tyrosine 48-56 interleukin 6 Homo sapiens 104-108 15725747-5 2005 Neonates exposed to nicotine during gestation showed a significant decrease in the number of bone marrow hematopoietic progenitors, as measured by colony-forming unit (CFU) and long-term culture initiating cell (LTC-IC) assays, and decreased concentration of interleukin-6 (IL-6) in their serum. Nicotine 20-28 interleukin 6 Homo sapiens 274-278 15472138-3 2005 Under the normoxic condition, adenosine and its stable analog, 5"-(N-ethylcarboxamido)-adenosine, via activation of A2B adenosine receptors, increased the release of interleukin (IL)-6 by 14-fold and induced the differentiation of human lung fibroblasts to myofibroblasts. Adenosine 30-39 interleukin 6 Homo sapiens 166-184 15582581-5 2005 Over the same concentration range of the nucleotide that was effective for IL-6 synthesis, ATP caused an increase in the intracellular Ca(2+) concentration ([Ca(2+)](i)), which increase was inhibited by pretreatment with suramin, a P2Y receptor antagonist, or 2-aminoethoxydiphenyl borate (2-APB), an inositol 1,4,5-trisphosphate receptor blocker, but not by the extracellular Ca(2+)-chelating agent EGTA. Egtazic Acid 400-404 interleukin 6 Homo sapiens 75-79 15582581-6 2005 The pretreatment of SaM-1 cells with suramin or 2-APB also inhibited the increase in IL-6 synthesis in response to ATP. Adenosine Triphosphate 115-118 interleukin 6 Homo sapiens 85-89 15582581-7 2005 These findings suggest that extracellular ATP-induced IL-6 synthesis occurs through P2Y receptors and mobilization of Ca(2+) from internal stores in human osteoblastic cells. Adenosine Triphosphate 42-45 interleukin 6 Homo sapiens 54-58 15383370-6 2005 IL-6 treatment alone increased (P < 0.05) lipolysis, but this effect was reduced by the addition of dexamethasone and GH such that IL-6 plus dexamethasone and GH had blunted (P < 0.05) lipolysis compared with IL-6 alone. Dexamethasone 103-116 interleukin 6 Homo sapiens 0-4 15383370-6 2005 IL-6 treatment alone increased (P < 0.05) lipolysis, but this effect was reduced by the addition of dexamethasone and GH such that IL-6 plus dexamethasone and GH had blunted (P < 0.05) lipolysis compared with IL-6 alone. Dexamethasone 103-116 interleukin 6 Homo sapiens 134-138 15383370-6 2005 IL-6 treatment alone increased (P < 0.05) lipolysis, but this effect was reduced by the addition of dexamethasone and GH such that IL-6 plus dexamethasone and GH had blunted (P < 0.05) lipolysis compared with IL-6 alone. Dexamethasone 103-116 interleukin 6 Homo sapiens 134-138 15383370-6 2005 IL-6 treatment alone increased (P < 0.05) lipolysis, but this effect was reduced by the addition of dexamethasone and GH such that IL-6 plus dexamethasone and GH had blunted (P < 0.05) lipolysis compared with IL-6 alone. Dexamethasone 144-157 interleukin 6 Homo sapiens 0-4 15383370-9 2005 Acute IL-6 treatment increased fatty acid turnover in D patients as well as healthy CON subjects. Fatty Acids 31-41 interleukin 6 Homo sapiens 6-10 15582581-0 2005 ATP-stimulated interleukin-6 synthesis through P2Y receptors on human osteoblasts. Adenosine Triphosphate 0-3 interleukin 6 Homo sapiens 15-28 15582581-1 2005 We investigated the effect of extracellular adenosine triphosphate (ATP) on the production of interleukin (IL)-6, whose molecules are capable of stimulating the development of osteoclasts from their hematopoietic precursors as well as are involved in signal transduction systems in human osteoblastic SaM-1 cells. Adenosine Triphosphate 44-66 interleukin 6 Homo sapiens 94-112 15582581-1 2005 We investigated the effect of extracellular adenosine triphosphate (ATP) on the production of interleukin (IL)-6, whose molecules are capable of stimulating the development of osteoclasts from their hematopoietic precursors as well as are involved in signal transduction systems in human osteoblastic SaM-1 cells. Adenosine Triphosphate 68-71 interleukin 6 Homo sapiens 94-112 15582581-3 2005 ATP increased gene- and protein-expression of IL-6 in SaM-1 cells. Adenosine Triphosphate 0-3 interleukin 6 Homo sapiens 46-50 15582581-4 2005 The expression of the IL-6 mRNA was maximal at 1h, and the increase in IL-6 synthesis in response to ATP (10-100 microM) occurred in a concentration-dependent manner. Adenosine Triphosphate 101-104 interleukin 6 Homo sapiens 22-26 15582581-4 2005 The expression of the IL-6 mRNA was maximal at 1h, and the increase in IL-6 synthesis in response to ATP (10-100 microM) occurred in a concentration-dependent manner. Adenosine Triphosphate 101-104 interleukin 6 Homo sapiens 71-75 15582581-5 2005 Over the same concentration range of the nucleotide that was effective for IL-6 synthesis, ATP caused an increase in the intracellular Ca(2+) concentration ([Ca(2+)](i)), which increase was inhibited by pretreatment with suramin, a P2Y receptor antagonist, or 2-aminoethoxydiphenyl borate (2-APB), an inositol 1,4,5-trisphosphate receptor blocker, but not by the extracellular Ca(2+)-chelating agent EGTA. Adenosine Triphosphate 91-94 interleukin 6 Homo sapiens 75-79 15383370-0 2005 Acute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitro. Fatty Acids 31-41 interleukin 6 Homo sapiens 6-10 15472138-7 2005 Altogether, these data suggest that hypoxia amplifies the effect of adenosine on the release of IL-6 and cell differentiation by upregulating the expression of A2B adenosine receptors. Adenosine 68-77 interleukin 6 Homo sapiens 96-100 16356228-2 2005 There is extensive evidence that glucose can stimulate the production of pro-inflammatory cytokines such as tumor necrosis factor (TNF)-alpha and IL-6, with no effect on the anti-inflammatory cytokine IL-10. Glucose 33-40 interleukin 6 Homo sapiens 146-150 15935563-0 2005 Cholesterol synthesis is the trigger and isoprenoid dependent interleukin-6 mediated inflammation is the common causative factor and therapeutic target for atherosclerotic vascular disease and age-related disorders including osteoporosis and type 2 diabetes. Cholesterol 0-11 interleukin 6 Homo sapiens 62-75 15936434-2 2005 The predicted 227 aa IL-6 homologue contains the IL-6/G-CSF/MGF motif, has a predicted secondary structure of four alpha-helixes but only contains two of the four cysteines important in disulphide bond formation. Cysteine 163-172 interleukin 6 Homo sapiens 21-25 16040399-7 2005 The T-cell proliferative response to DC was enhanced by inclusion of PGE2 in the MCM-mimic (TNF-a, IL-1 a, IL-6, PGE2) cocktail. Dinoprostone 69-73 interleukin 6 Homo sapiens 107-111 15618130-9 2005 Furthermore, AIE decreased the phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated tumor necrosis factor-alpha and interleukin-6 gene expression and production in human mast cells. Tetradecanoylphorbol Acetate 31-62 interleukin 6 Homo sapiens 142-155 15611272-7 2005 Incubation of HLM with the sPLA(2)s was associated with phosphorylation of ERK1/2, and a specific inhibitor of this pathway, PD98059, significantly reduced the production of IL-6 elicited by sPLA(2)s. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 125-132 interleukin 6 Homo sapiens 174-178 15616014-9 2005 Pan-protein kinase C (PKC) inhibitors significantly decreased high-glucose-induced IL-6 release. Glucose 67-74 interleukin 6 Homo sapiens 83-87 15616014-11 2005 Furthermore, the PKC-alpha/beta2 inhibitor decreased p38MAPK and the resulting high-glucose-induced IL-6 release. Glucose 84-91 interleukin 6 Homo sapiens 100-104 15616014-12 2005 Both antisense oligos to PKC-beta and -alpha as well as small interfering RNA (siRNA) to PKC-alpha and -beta resulted in significantly decreased high-glucose-induced IL-6 release. Glucose 150-157 interleukin 6 Homo sapiens 166-170 15618130-9 2005 Furthermore, AIE decreased the phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated tumor necrosis factor-alpha and interleukin-6 gene expression and production in human mast cells. Tetradecanoylphorbol Acetate 64-67 interleukin 6 Homo sapiens 142-155 15618130-9 2005 Furthermore, AIE decreased the phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated tumor necrosis factor-alpha and interleukin-6 gene expression and production in human mast cells. Calcium 74-81 interleukin 6 Homo sapiens 142-155 16761388-6 2005 The drug has been shown experimentally to inhibit the IL-6-induced proliferation of myeloma cells; it demonstrates synergy with dexamethasone and inhibits angiogenesis. Dexamethasone 128-141 interleukin 6 Homo sapiens 54-58 16173059-3 2005 TRPV1 antagonists and reduction of calcium concentrations in treatment solutions attenuated calcium flux, induction of interleukin-6 and 8 gene expression, and IL-6 secretion by cells treated with capsaicin or resiniferatoxin. Calcium 35-42 interleukin 6 Homo sapiens 119-138 16173059-3 2005 TRPV1 antagonists and reduction of calcium concentrations in treatment solutions attenuated calcium flux, induction of interleukin-6 and 8 gene expression, and IL-6 secretion by cells treated with capsaicin or resiniferatoxin. Calcium 35-42 interleukin 6 Homo sapiens 160-164 16173059-3 2005 TRPV1 antagonists and reduction of calcium concentrations in treatment solutions attenuated calcium flux, induction of interleukin-6 and 8 gene expression, and IL-6 secretion by cells treated with capsaicin or resiniferatoxin. Capsaicin 197-206 interleukin 6 Homo sapiens 119-138 16173059-3 2005 TRPV1 antagonists and reduction of calcium concentrations in treatment solutions attenuated calcium flux, induction of interleukin-6 and 8 gene expression, and IL-6 secretion by cells treated with capsaicin or resiniferatoxin. Capsaicin 197-206 interleukin 6 Homo sapiens 160-164 15935563-1 2005 This is a unifying theory that cholesterol metabolites (isoprenoids) are an integral component of the signaling pathway for interleukin-6 (IL-6) mediated inflammation. Cholesterol 31-42 interleukin 6 Homo sapiens 124-137 15935563-1 2005 This is a unifying theory that cholesterol metabolites (isoprenoids) are an integral component of the signaling pathway for interleukin-6 (IL-6) mediated inflammation. Cholesterol 31-42 interleukin 6 Homo sapiens 139-143 15935563-7 2005 Prevention of atherosclerotic vascular disease and age-related disorders will be by utilization of cholesterol lowering agents or techniques and/or treatment with statins and/or bisphosphonates to inhibit IL-6 inflammation through regulation of cholesterol metabolism. Cholesterol 245-256 interleukin 6 Homo sapiens 205-209 15780504-5 2005 In a recent clinical trial targeting elderly chronically ill patients, administration of vitamin D reduced serum levels of both CRP and IL-6; further such studies should assess the impact of physiologically meaningful doses of vitamin D on acute phase reactants in elderly subjects likely to have poor vitamin D status. Vitamin D 89-98 interleukin 6 Homo sapiens 136-140 15761385-10 2005 Increase in monocyte chemotaxis and increased interleukin 6 secretion in response to extracellular calcium were observed. Calcium 99-106 interleukin 6 Homo sapiens 46-59 15893120-0 2005 Using histamine (H1) antagonists, in particular atypical antipsychotics, to treat anemia of chronic disease via interleukin-6 suppression. Histamine 6-15 interleukin 6 Homo sapiens 112-125 15893120-7 2005 Here, we note that an immediately available and potentially effective treatment for ACD is to decrease Il-6 levels by histamine (H1) receptor antagonism, given that histamine acting through the H1 receptor is known to be a potent positive regulator of Il-6. Histamine 118-127 interleukin 6 Homo sapiens 103-107 15625014-3 2004 In K562 leukemia cells, treatment with interleukin-6 (IL-6) or granulocyte-macrophage colony stimulating factor (GM-CSF) reduced the proportion of the Bcl-xL variant mRNA while treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) had no effect. Tetradecanoylphorbol Acetate 192-228 interleukin 6 Homo sapiens 39-52 15604281-6 2004 Complementary DNA microarray expression profiling allowed us to identify a subset of genes specifically regulated by tamoxifen and CC-8490, and not by other apoptotic stimuli, including nuclear factor (NF)-kappaB with its target genes IEX-3, SOD2, IL6, and IL8. Tamoxifen 117-126 interleukin 6 Homo sapiens 248-251 15304377-2 2004 Because 1) IL-6 mRNA expression in contracting skeletal muscle is enhanced by low muscle glycogen content, and 2) IL-6 increases lipolysis and oxidation of fatty acids, we hypothesized that regular exercise training, associated with increased levels of resting muscle glycogen and enhanced capacity to oxidize fatty acids, would lead to a less-pronounced increase of skeletal muscle IL-6 mRNA in response to acute exercise. Fatty Acids 169-180 interleukin 6 Homo sapiens 127-131 15304377-2 2004 Because 1) IL-6 mRNA expression in contracting skeletal muscle is enhanced by low muscle glycogen content, and 2) IL-6 increases lipolysis and oxidation of fatty acids, we hypothesized that regular exercise training, associated with increased levels of resting muscle glycogen and enhanced capacity to oxidize fatty acids, would lead to a less-pronounced increase of skeletal muscle IL-6 mRNA in response to acute exercise. Fatty Acids 169-180 interleukin 6 Homo sapiens 127-131 15271650-6 2004 IL-1beta and IL-6 reduced contraction in response to EFS (2-10 Hz, 0.2 ms) but did not affect ACh-induced contraction, suggesting that these cytokines inhibit ACh release without affecting myogenic contractile mechanisms. Acetylcholine 159-162 interleukin 6 Homo sapiens 13-17 15271650-7 2004 EFS-induced ACh release was significantly reduced in normal esophageal strips by incubation in IL-1beta or IL-6, suggesting that they may contribute to the contractility changes. Acetylcholine 12-15 interleukin 6 Homo sapiens 107-111 15271650-10 2004 The data suggest that the proinflammatory cytokines IL-1beta and IL-6 contribute to reduced esophageal contraction by inhibiting release of ACh from myenteric neurons. Acetylcholine 140-143 interleukin 6 Homo sapiens 65-69 15625014-3 2004 In K562 leukemia cells, treatment with interleukin-6 (IL-6) or granulocyte-macrophage colony stimulating factor (GM-CSF) reduced the proportion of the Bcl-xL variant mRNA while treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) had no effect. Tetradecanoylphorbol Acetate 192-228 interleukin 6 Homo sapiens 54-58 15625014-3 2004 In K562 leukemia cells, treatment with interleukin-6 (IL-6) or granulocyte-macrophage colony stimulating factor (GM-CSF) reduced the proportion of the Bcl-xL variant mRNA while treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) had no effect. Tetradecanoylphorbol Acetate 230-233 interleukin 6 Homo sapiens 39-52 15625014-3 2004 In K562 leukemia cells, treatment with interleukin-6 (IL-6) or granulocyte-macrophage colony stimulating factor (GM-CSF) reduced the proportion of the Bcl-xL variant mRNA while treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) had no effect. Tetradecanoylphorbol Acetate 230-233 interleukin 6 Homo sapiens 54-58 15529027-7 2004 Genetic variants of the apolipoprotein E and interleukin 6 genes in humans may modify how alcohol influences atherosclerosis, further emphasizing the importance of HDL-C and inflammatory factors as mediators. Alcohols 90-97 interleukin 6 Homo sapiens 45-58 15507399-3 2004 Addition of iron to the culture medium did not affect the secretion of IL-2 and IL-1beta, but caused an increase in IL-6, IL-10, and TNF-alpha production. Iron 12-16 interleukin 6 Homo sapiens 116-120 15528032-0 2004 Protective effects of 17beta-estradiol and trivalent chromium on interleukin-6 secretion, oxidative stress, and adhesion of monocytes: relevance to heart disease in postmenopausal women. Estradiol 22-38 interleukin 6 Homo sapiens 65-78 15569129-14 2004 Furthermore, the increase in myocardial glucose uptake correlated inversely with interleukin-6 (IL-6) concentrations (r = -0.58, P = 0.03). Glucose 40-47 interleukin 6 Homo sapiens 81-94 15569129-14 2004 Furthermore, the increase in myocardial glucose uptake correlated inversely with interleukin-6 (IL-6) concentrations (r = -0.58, P = 0.03). Glucose 40-47 interleukin 6 Homo sapiens 96-100 15526270-9 2004 In contrast, all river-water samples triggered secretion of proinflammatory cytokines, as shown for TNF-alpha, IL-1beta, and IL-6. Water 23-28 interleukin 6 Homo sapiens 125-129 15528032-2 2004 We examined the hypothesis that 17beta-estradiol and trivalent chromium inhibit secretion of the pro-inflammatory cytokine interleukin (IL)-6 and oxidative stress in monocytes exposed to high glucose (HG). Estradiol 32-48 interleukin 6 Homo sapiens 123-141 15528032-2 2004 We examined the hypothesis that 17beta-estradiol and trivalent chromium inhibit secretion of the pro-inflammatory cytokine interleukin (IL)-6 and oxidative stress in monocytes exposed to high glucose (HG). Glucose 192-199 interleukin 6 Homo sapiens 123-141 15528032-5 2004 Treatment with 17beta-estradiol+Cr(3+) required a significantly lower dose of estradiol-17beta compared with 17beta-estradiol alone for IL-6 inhibition. Estradiol 15-31 interleukin 6 Homo sapiens 136-140 15528032-5 2004 Treatment with 17beta-estradiol+Cr(3+) required a significantly lower dose of estradiol-17beta compared with 17beta-estradiol alone for IL-6 inhibition. Estradiol 78-94 interleukin 6 Homo sapiens 136-140 15528032-7 2004 Thus, 17beta-estradiol+Cr(3+) inhibits oxidative stress, IL-6 secretion, and monocytic adhesion to endothelial cells, risk factors in the development of heart disease. Estradiol 6-22 interleukin 6 Homo sapiens 57-61 15663638-10 2004 Significant positive correlations were found between malondialdehyde and interleukin-1beta, interleukin-6, leptin and lipoprotein (a) (P <0.05). Malondialdehyde 53-68 interleukin 6 Homo sapiens 92-105 15654514-4 2004 RESULTS: HMC-1 produced substantial amounts of GM-CSF and IL-8 and smaller amounts of TNF-alpha, IL-4 and IL-6 after being stimulated with PMA together with A23187. Tetradecanoylphorbol Acetate 139-142 interleukin 6 Homo sapiens 106-110 15590982-5 2004 Furthermore, 100 nM dexamethasone and 30 ng/ml interleukin (IL)-6 induced SAA3 mRNA by up to 11- and 4.8-fold, respectively, in a time-dependent fashion with significant stimulation observed at concentrations as low as 10 nM dexamethasone and 1 ng/ml IL-6. Dexamethasone 20-33 interleukin 6 Homo sapiens 251-255 15815878-6 2004 In a multiple logistic regression model that included inflammatory markers and clinical risk factors, antibody to PF4/heparin was a strong predictor of 30 day MI (odds ratio: 9.0; 95% confidence intervals 2.1-38.6; p < 0.01), with IL-6 being the only other predictor (odds ratio: 1.1; 95% confidence intervals 1.0-1.2; p = 0.03). Heparin 118-125 interleukin 6 Homo sapiens 234-238 15587302-8 2004 Serum IL-6 significantly increased in G.I (P < 0.001) & G.II (P < 0.05) compared with G.III, and was significantly higher (P < 0.001) in G.I than G.II. Adenosine Monophosphate 58-61 interleukin 6 Homo sapiens 6-10 15531669-9 2004 Moreover, negative correlations were observed between IL-6 and serum creatinine (rho = -0.19, P < 0.01), handgrip strength (rho = -0.24, P < 0.001), and serum albumin (rho = -0.34, P < 0.001). Creatinine 69-79 interleukin 6 Homo sapiens 54-58 15496611-6 2004 IL-1 beta, IL-6, IL-8 and TNF-alpha were significantly associated with lactate/choline in the DGN (p = 0.03, 0.02, 0.03, and 0.01 respectively), but not in the WS (all p > 0.1). Lactic Acid 71-78 interleukin 6 Homo sapiens 11-15 15563698-2 2004 The aim of this study was to investigate whether short term supplementary oxygen (28%) increases oxidative stress and inflammation in the airways by measuring 8-isoprostane and interleukin 6 (IL-6) concentrations in exhaled breath condensate. Oxygen 74-80 interleukin 6 Homo sapiens 177-190 15563698-2 2004 The aim of this study was to investigate whether short term supplementary oxygen (28%) increases oxidative stress and inflammation in the airways by measuring 8-isoprostane and interleukin 6 (IL-6) concentrations in exhaled breath condensate. Oxygen 74-80 interleukin 6 Homo sapiens 192-196 15563698-5 2004 RESULTS: Increased concentrations of 8-isoprostane and IL-6 were found in all subjects after breathing 28% oxygen for 1 hour. Oxygen 107-113 interleukin 6 Homo sapiens 55-59 15547537-7 2004 In CLD infants, IL-6 was higher in the infants who required prolonged oxygen therapy (P < .05). Oxygen 70-76 interleukin 6 Homo sapiens 16-20 15531669-11 2004 Inverse correlations were observed between plasma IL-6 and HDL cholesterol (rho = -0.16, P < 0.05) and apolipoprotein A (rho = -0.23, P < 0.001). Cholesterol 63-74 interleukin 6 Homo sapiens 50-54 15256361-1 2004 Adenosine, acting through the A2b receptor, induces vectorial chloride and IL-6 secretion in intestinal epithelia and may play an important role in intestinal inflammation. Adenosine 0-9 interleukin 6 Homo sapiens 75-79 15284182-3 2004 IL-6 induced prominent tyrosine phosphorylation of the transcription factor STAT1 in both cell types. Tyrosine 23-31 interleukin 6 Homo sapiens 0-4 15488879-8 2004 The use of atorvastatin when compared to diet alone, resulted in significant (P <0.0001) reductions for: LDL-cholesterol (39.9% versus 4.4%), TNF (21.4% versus 2.9%), IL-6 (22.1% versus 2.0%), IL-1 (16.4% versus 2.7%) and sICAM-1 (9.6% versus 0.1%), respectively. Atorvastatin 11-23 interleukin 6 Homo sapiens 170-174 15488879-10 2004 CONCLUSION: In hypercholesterolemic patients, atorvastatin, compared to diet alone resulted in significant reductions in levels of proinflammatory cytokines (TNF, IL-1 and IL-6) as well as in sICAM-1 and CRP. Atorvastatin 46-58 interleukin 6 Homo sapiens 172-176 15726915-14 2004 Serum levels of IL-6 were also significantly correlated with the serum levels of HDL-cholesterol, LDL-cholesterol and body mass index (BMI) in pre-eclamptic women (r=0.40, p < 0.01; r=-0.568, p < 0.01; r= -0.30, p < 0.05, respectively). Cholesterol 85-96 interleukin 6 Homo sapiens 16-20 15345683-9 2004 We next incubated L6 myotubes in ionomycin (a compound known to induce IL-6 mRNA) with or without the pyridinylimidazole p38 MAPK inhibitor SB203580. Ionomycin 33-42 interleukin 6 Homo sapiens 71-75 15345683-10 2004 Treatments did not affect total nuclear p38 MAPK, but ionomycin increased (P<0.05) both nuclear p-p38 MAPK and IL-6 mRNA. Ionomycin 54-63 interleukin 6 Homo sapiens 114-118 15345683-11 2004 The addition of SB203580 to ionomycin decreased (P<0.05) nuclear p-p38 MAPK and totally abolished (P<0.05) the ionomycin- induced increase in IL-6 mRNA. Ionomycin 28-37 interleukin 6 Homo sapiens 148-152 15345683-11 2004 The addition of SB203580 to ionomycin decreased (P<0.05) nuclear p-p38 MAPK and totally abolished (P<0.05) the ionomycin- induced increase in IL-6 mRNA. Ionomycin 117-126 interleukin 6 Homo sapiens 148-152 15726915-14 2004 Serum levels of IL-6 were also significantly correlated with the serum levels of HDL-cholesterol, LDL-cholesterol and body mass index (BMI) in pre-eclamptic women (r=0.40, p < 0.01; r=-0.568, p < 0.01; r= -0.30, p < 0.05, respectively). Cholesterol 102-113 interleukin 6 Homo sapiens 16-20 15505230-4 2004 In the extracellular environment, HOCl and TauCl may directly neutralize interleukin 6 (IL-6) and several metalloproteinases, while HOCl increases the capacity of alpha(2)-macroglobulin to bind Tumor Necrosis Factor-alpha, IL-2, and IL-6, and facilitates the release of various growth factors. Hypochlorous Acid 34-38 interleukin 6 Homo sapiens 73-86 15591791-5 2004 Furthermore, vanadate potentiated IL-6-signaling pathway by increasing the tyrosine phosphorylated levels of STAT3 (Tyr705), and Lyn. Tyrosine 75-83 interleukin 6 Homo sapiens 34-38 15313471-5 2004 IL6, but not LIF or OSM inhibited proliferation, induced NE differentiation and tyrosine phosphorylation of STAT3 in LNCaP cells. Tyrosine 80-88 interleukin 6 Homo sapiens 0-3 15505230-4 2004 In the extracellular environment, HOCl and TauCl may directly neutralize interleukin 6 (IL-6) and several metalloproteinases, while HOCl increases the capacity of alpha(2)-macroglobulin to bind Tumor Necrosis Factor-alpha, IL-2, and IL-6, and facilitates the release of various growth factors. Hypochlorous Acid 34-38 interleukin 6 Homo sapiens 88-92 15762036-0 2004 Effects of 17beta-estradiol, tamoxifen and raloxifene on the protein and mRNA expression of interleukin-6, transforming growth factor-beta1 and insulin-like growth factor-1 in primary human osteoblast cultures. Estradiol 11-27 interleukin 6 Homo sapiens 92-105 15762036-0 2004 Effects of 17beta-estradiol, tamoxifen and raloxifene on the protein and mRNA expression of interleukin-6, transforming growth factor-beta1 and insulin-like growth factor-1 in primary human osteoblast cultures. Tamoxifen 29-38 interleukin 6 Homo sapiens 92-105 15173946-4 2004 The massive and continuous IL-6 release induces an acute phase response, but, more importantly, also accounts for the up-regulation of major anti-inflammatory mediators, such as prostaglandin (PG) E2, IL-10 and transforming growth factor (TGF)-ss. Dinoprostone 178-199 interleukin 6 Homo sapiens 27-31 15308634-0 2004 Overexpression of phospholipid-hydroperoxide glutathione peroxidase in human dermal fibroblasts abrogates UVA irradiation-induced expression of interstitial collagenase/matrix metalloproteinase-1 by suppression of phosphatidylcholine hydroperoxide-mediated NFkappaB activation and interleukin-6 release. Hydrogen Peroxide 31-44 interleukin 6 Homo sapiens 281-294 15533496-9 2004 The IL-6 levels correlated significantly with the ROS levels in the infertile patients with varicocele (r = -0.39; P = 0.01). Reactive Oxygen Species 50-53 interleukin 6 Homo sapiens 4-8 15533212-0 2004 Regulation of interleukin-6 expression by arecoline in human buccal mucosal fibroblasts is related to intracellular glutathione levels. Glutathione 116-127 interleukin 6 Homo sapiens 14-27 15533212-10 2004 IL-6 gene regulated by arecoline correlated with intracellular GSH levels in BMF. Glutathione 63-66 interleukin 6 Homo sapiens 0-4 15533212-15 2004 In addition, the regulation of IL-6 expression induced by arecoline is critically dependent on the intracellular GSH concentrations. Glutathione 113-116 interleukin 6 Homo sapiens 31-35 15345332-6 2004 Furthermore, both SB203580 (an inhibitor of p38 mitogen-activated protein kinase [MAPK]) and PD98059 (an inhibitor of MEK, upstream of ERK) attenuated the BK-induced IL-6 and PGE(2) synthesis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 93-100 interleukin 6 Homo sapiens 166-170 15299003-3 2004 Our results show that upon activation of the ryanodine receptor (RYR), myotubes release interleukin-6 (IL-6); this was dependent on de novo protein synthesis and could be blocked by dantrolene and cyclosporine. Cyclosporine 197-209 interleukin 6 Homo sapiens 88-101 15299003-3 2004 Our results show that upon activation of the ryanodine receptor (RYR), myotubes release interleukin-6 (IL-6); this was dependent on de novo protein synthesis and could be blocked by dantrolene and cyclosporine. Cyclosporine 197-209 interleukin 6 Homo sapiens 103-107 15299003-7 2004 Taken together, these results suggest that abnormal release of calcium via mutated RYR enhances the production of the inflammatory cytokine IL-6, which may in turn affect signaling pathways responsible for the trophic status of muscle fibers. Calcium 63-70 interleukin 6 Homo sapiens 140-144 15363595-0 2004 Iron-induced interleukin-6 gene expression: possible mediation through the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways. Iron 0-4 interleukin 6 Homo sapiens 13-26 15363595-7 2004 Levels of interleukin-6 (IL-6), a pro-inflammatory cytokine, were increased in JB6 cells by iron in a dose-dependent manner. Iron 92-96 interleukin 6 Homo sapiens 10-23 15363595-7 2004 Levels of interleukin-6 (IL-6), a pro-inflammatory cytokine, were increased in JB6 cells by iron in a dose-dependent manner. Iron 92-96 interleukin 6 Homo sapiens 25-29 15363595-8 2004 The increase in IL-6 and its mRNA by iron was also eliminated by the pretreatment of the cells with PD98059 and SB202190. Iron 37-41 interleukin 6 Homo sapiens 16-20 15363595-8 2004 The increase in IL-6 and its mRNA by iron was also eliminated by the pretreatment of the cells with PD98059 and SB202190. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 100-107 interleukin 6 Homo sapiens 16-20 15363595-9 2004 Since the IL-6 promoter contains an AP-1 binding site, our studies indicate that the iron-induced IL-6 gene expression may be mediated through ERKs and p38 MAPK pathways, possibly one of the important mechanisms for the pathogenesis of iron overload. Iron 85-89 interleukin 6 Homo sapiens 10-14 15363595-9 2004 Since the IL-6 promoter contains an AP-1 binding site, our studies indicate that the iron-induced IL-6 gene expression may be mediated through ERKs and p38 MAPK pathways, possibly one of the important mechanisms for the pathogenesis of iron overload. Iron 85-89 interleukin 6 Homo sapiens 98-102 15363595-9 2004 Since the IL-6 promoter contains an AP-1 binding site, our studies indicate that the iron-induced IL-6 gene expression may be mediated through ERKs and p38 MAPK pathways, possibly one of the important mechanisms for the pathogenesis of iron overload. Iron 236-240 interleukin 6 Homo sapiens 10-14 15363595-9 2004 Since the IL-6 promoter contains an AP-1 binding site, our studies indicate that the iron-induced IL-6 gene expression may be mediated through ERKs and p38 MAPK pathways, possibly one of the important mechanisms for the pathogenesis of iron overload. Iron 236-240 interleukin 6 Homo sapiens 98-102 15476200-10 2004 In addition, dexamethasone augmented IL-1beta-induced up-regulation of MKP-1, and this was associated with inhibition of ERK, JNK, and p38 MAPK phosphorylation and IL-6 expression. Dexamethasone 13-26 interleukin 6 Homo sapiens 164-168 15381186-1 2004 Inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) may have a direct effect on glucose and lipid metabolism. Glucose 124-131 interleukin 6 Homo sapiens 31-44 15381186-1 2004 Inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) may have a direct effect on glucose and lipid metabolism. Glucose 124-131 interleukin 6 Homo sapiens 46-50 15265001-5 2004 Both the low-fat and the very-low-carbohydrate diets resulted in significant decreases in absolute concentrations of hsTNF-alpha (high-sensitivity tumour necrosis factor-alpha), hsIL-6 (high-sensitivity interleukin-6), hsCRP (high-sensitivity C-reactive protein) and sICAM-1 (soluble intercellular cell-adhesion molecule-1). Carbohydrates 34-46 interleukin 6 Homo sapiens 203-216 15180970-9 2004 In conclusion, fasting glucose and the extent to which glucose tolerance changes with exercise training may be influenced by the IL-6 -174 gene polymorphism. Glucose 23-30 interleukin 6 Homo sapiens 129-133 15379983-7 2004 Histamine alone markedly enhanced IL-6 mRNA expression in HUVEC, but it did not stimulate proportional IL-6 release. Histamine 0-9 interleukin 6 Homo sapiens 34-38 15379983-8 2004 When HUVEC were incubated with LPS, LTA, or PGN in the presence of histamine marked amplification of both IL-6 production and mRNA expression was noted. Histamine 67-76 interleukin 6 Homo sapiens 106-110 15180970-0 2004 Influence of the interleukin-6 -174 G/C gene polymorphism on exercise training-induced changes in glucose tolerance indexes. Glucose 98-105 interleukin 6 Homo sapiens 17-30 15180970-9 2004 In conclusion, fasting glucose and the extent to which glucose tolerance changes with exercise training may be influenced by the IL-6 -174 gene polymorphism. Glucose 55-62 interleukin 6 Homo sapiens 129-133 15180970-6 2004 The training-induced change in glucose area under the curve during the oral glucose tolerance test varied between the IL-6 -174 genotype groups (P = 0.05, covariates age, gender, ethnicity, baseline glucose area under the curve, and percent body fat change) with a significant decrease occurring only in the GG genotype group. Glucose 31-38 interleukin 6 Homo sapiens 118-122 15313415-0 2004 Soy isoflavone phyto-pharmaceuticals in interleukin-6 affections. Isoflavones 0-14 interleukin 6 Homo sapiens 40-53 15379866-7 2004 Upon addition of PGE2, however, LPS-induced IL-6 and TNF-alpha production was suppressed regardless of indomethacin presence. Dinoprostone 17-21 interleukin 6 Homo sapiens 44-48 15252833-4 2004 The modulation of RCC cell line proliferation by an anti-IL-6 Ab, an IL-6 antisense oligonucleotide (ASON) directed against the second exon of IL-6 and cytokines inhibiting IL-6 production (IL-4 and IL-13) was investigated. Oligonucleotides 84-99 interleukin 6 Homo sapiens 69-73 15252833-4 2004 The modulation of RCC cell line proliferation by an anti-IL-6 Ab, an IL-6 antisense oligonucleotide (ASON) directed against the second exon of IL-6 and cytokines inhibiting IL-6 production (IL-4 and IL-13) was investigated. Oligonucleotides 84-99 interleukin 6 Homo sapiens 69-73 15252833-4 2004 The modulation of RCC cell line proliferation by an anti-IL-6 Ab, an IL-6 antisense oligonucleotide (ASON) directed against the second exon of IL-6 and cytokines inhibiting IL-6 production (IL-4 and IL-13) was investigated. Oligonucleotides 84-99 interleukin 6 Homo sapiens 69-73 15313415-3 2004 After menopause or andropause, loss of the normally inhibiting sex steroids (estrogen, testosterone) results in elevated IL6 levels that are further progressively increasing with age. Steroids 67-75 interleukin 6 Homo sapiens 121-124 15313415-3 2004 After menopause or andropause, loss of the normally inhibiting sex steroids (estrogen, testosterone) results in elevated IL6 levels that are further progressively increasing with age. Testosterone 87-99 interleukin 6 Homo sapiens 121-124 15297382-3 2004 We have evolved an effective cytokine cocktail (thrombopoietin, stem cell factor, interleukin [IL]-1beta, IL-6) that induces a high yield of CD platelets and optimal shedding from cultivated megakaryocytes generated from CD34(+) progenitor cells. Cadmium 141-143 interleukin 6 Homo sapiens 106-110 15372363-2 2004 AIM: The aim of the study was therefore to test the hypothesis that in children and adolescents IL-6 is of importance for the etiopathogenesis of diabetes mellitus type 1 and that IL-6 is connected with carbohydrate metabolism and IGF-IGFBPs action. Carbohydrates 203-215 interleukin 6 Homo sapiens 180-184 15517885-4 2004 Resveratrol has been shown to suppress the activation of several transcription factors, including NF-kappaB, AP-1 and Egr-1; to inhibit protein kinases including IkappaBalpha kinase, JNK, MAPK, Akt, PKC, PKD and casein kinase II; and to down-regulate products of genes such as COX-2, 5-LOX, VEGF, IL-1, IL-6, IL-8, AR and PSA. Resveratrol 0-11 interleukin 6 Homo sapiens 303-307 17670296-5 2004 We conclude that steroids may reduce Troponin I release, CRP and reduce Interleukin-6. Steroids 17-25 interleukin 6 Homo sapiens 72-85 15072962-6 2004 In addition, the fold change for both IL-8 and IL-6 was markedly higher (P < 0.05) in Lo Gly compared with Con. Glycine 92-95 interleukin 6 Homo sapiens 47-51 15526907-6 2004 Importantly, PPARgamma agonists troglitazone, rosiglitazone, and 15-deoxy-delta(12, 14)-prosglandin J2 significantly decreased the up expression of TNF-alpha and IL-6 in HMCL supernatants stimulated by IL-1beta. Rosiglitazone 46-59 interleukin 6 Homo sapiens 162-166 15297015-8 2004 Furthermore, the Be-specific pattern of IL6 and IL10 release is dependent upon induction of threonine phosphorylation of a 45 kDa cytosolic protein (p45), as early as 90 min after Be treatment. Threonine 92-101 interleukin 6 Homo sapiens 40-43 15297015-11 2004 These findings suggest that the balance between IL10 and IL6 release and the correlated p45 phosphorylation are important components of the Be-mediated immune response in healthy individuals. Beryllium 140-142 interleukin 6 Homo sapiens 57-60 15670667-0 2004 Therapeutic potential of interleukin-6 in preventing obesity- and alcohol-associated fatty liver transplant failure. Alcohols 66-73 interleukin 6 Homo sapiens 25-38 15670667-10 2004 Higher concentrations of IL-6 may be required to protect against alcoholic fatty liver isograft injury because alcohol inhibits IL-6 signaling in the liver. Alcohols 65-72 interleukin 6 Homo sapiens 25-29 15129368-4 2004 In addition, PD098059 as well as simvastatin and the FTase inhibitor abolished alkaline phosphatase activity and/or osteocalcin mRNA induction by the IL-6/IL-6sR in these cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-21 interleukin 6 Homo sapiens 150-154 15129368-4 2004 In addition, PD098059 as well as simvastatin and the FTase inhibitor abolished alkaline phosphatase activity and/or osteocalcin mRNA induction by the IL-6/IL-6sR in these cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-21 interleukin 6 Homo sapiens 155-159 15254731-0 2004 Retinoic acid inhibits IL-6-dependent but not constitutive STAT3 activation in Epstein-Barr virus-immortalized B lymphocytes. Tretinoin 0-13 interleukin 6 Homo sapiens 23-27 15180965-8 2004 Although PGE2 also induces IL-1beta and IL-6 expression in non-stimulated DCs, the stimulatory effect of PGE2 on IL-23 production is not mediated through IL-1beta or IL-6. Dinoprostone 9-13 interleukin 6 Homo sapiens 40-44 15253951-8 2004 Inhibition of lipopolysaccharide stimulated IL-6 and TNFalpha release by either glucocorticoid was less pronounced in samples from men than in those from women (IL-6: dexamethasone p = 0.033, hydrocortisone p = 0.029; TNFalpha: dexamethasone p < 0.001, hydrocortisone p = 0.089). Dexamethasone 228-241 interleukin 6 Homo sapiens 44-48 15253951-8 2004 Inhibition of lipopolysaccharide stimulated IL-6 and TNFalpha release by either glucocorticoid was less pronounced in samples from men than in those from women (IL-6: dexamethasone p = 0.033, hydrocortisone p = 0.029; TNFalpha: dexamethasone p < 0.001, hydrocortisone p = 0.089). Hydrocortisone 256-270 interleukin 6 Homo sapiens 44-48 15254731-5 2004 RA-induced modulation of IL-6 receptor components did not abolish IL-6-mediated phosphorylation of gp130, whereas JAK1 and STAT3 phosphorylation and activation induced by IL-6 were markedly inhibited. Tretinoin 0-2 interleukin 6 Homo sapiens 25-29 15254731-6 2004 Overall, the effects of RA resulted in the induction of a complete resistance of LCLs to IL-6-mediated growth promotion. Tretinoin 24-26 interleukin 6 Homo sapiens 89-93 15254731-8 2004 The finding that RA severely impairs IL-6-dependent signalings in LCLs and inhibits their growth despite the presence of constitutively active JAK/STAT and MAPK cascades provide additional support for a role of RA in the prevention and treatment of EBV-related lymphoproliferative disorders of immunosuppressed patients. Tretinoin 17-19 interleukin 6 Homo sapiens 37-41 15255954-2 2004 Here we show that beta-naphthoflavone (betaNF), an agonist of the aryl hydrocarbon receptor (AhR), disturbed the cAMP-induced astrocytic differentiation of C6 glioma by inhibiting autocrine interleukin-6 (IL-6). Cyclic AMP 113-117 interleukin 6 Homo sapiens 190-203 15255954-2 2004 Here we show that beta-naphthoflavone (betaNF), an agonist of the aryl hydrocarbon receptor (AhR), disturbed the cAMP-induced astrocytic differentiation of C6 glioma by inhibiting autocrine interleukin-6 (IL-6). Cyclic AMP 113-117 interleukin 6 Homo sapiens 205-209 15265671-2 2004 15d-PGJ2 inhibited a broad range of astrocyte inflammatory gene expression induced by IL-1, including cytokines (TNFalpha and IL-6), chemokines (RANTES/CCL5 and IP-10/CXCL10) and inducible nitric oxide synthase. 15-deoxyprostaglandin J2 0-8 interleukin 6 Homo sapiens 126-130 15245788-2 2004 To examine this problem, we used human recombinant IL-6 applied intranasally (400 ng/40 microl) to rats 1h before seizures induced by systemic injection of pentylenenetrazole (PTZ, 75 mg/kg). Hydrogen 104-106 interleukin 6 Homo sapiens 51-55 15304054-6 2004 We found that oscillating glucose was more effective in triggering the generation of nitrotyrosine and inducing the expression of adhesion molecules and IL-6 than stable high glucose. Glucose 26-33 interleukin 6 Homo sapiens 153-157 15276019-0 2004 Pigment epithelium-derived factor inhibits TNF-alpha-induced interleukin-6 expression in endothelial cells by suppressing NADPH oxidase-mediated reactive oxygen species generation. Reactive Oxygen Species 145-168 interleukin 6 Homo sapiens 61-74 15304054-0 2004 Intermittent high glucose enhances ICAM-1, VCAM-1, E-selectin and interleukin-6 expression in human umbilical endothelial cells in culture: the role of poly(ADP-ribose) polymerase. Glucose 18-25 interleukin 6 Homo sapiens 66-79 15242697-3 2004 Steroids modulate some plasma cytokines (decreasing TNFalpha, IL-8, IL-6 and increasing IL-10), whereas ability to reduce plasma and urinary TNFsr-2 and IL-1ra and peri-operative renal injury is unknown. Steroids 0-8 interleukin 6 Homo sapiens 68-72 14634855-2 2004 In addition, preoperative administration of ibuprofen has proved to reduce interleukin-6 (IL-6) release, while that of ranitidine reduced postoperative IL-6-induced C-reactive protein synthesis in patients undergoing abdominal surgery. Ibuprofen 44-53 interleukin 6 Homo sapiens 75-88 15213629-10 2004 TNF-alpha and IL-6 cytokine responses to LPS were markedly influenced by the specific progenitor cells involved as well as the injury conditions and the status of norepinephrine prior to injury. Norepinephrine 163-177 interleukin 6 Homo sapiens 14-18 15213629-11 2004 In burn sepsis the depletion of norepinephrine resulted in a dramatic decrease in both IL-6 and TNF-alpha production by both progenitor-derived macrophages. Norepinephrine 32-46 interleukin 6 Homo sapiens 87-91 15157952-5 2004 Coupled with prolonged sleep latency and increased rapid eye movement sleep, alcoholics showed nocturnal elevations of IL-6 and TNF as compared to controls after adjustment for alcohol consumption and body mass index. Alcohols 77-84 interleukin 6 Homo sapiens 119-123 14634855-2 2004 In addition, preoperative administration of ibuprofen has proved to reduce interleukin-6 (IL-6) release, while that of ranitidine reduced postoperative IL-6-induced C-reactive protein synthesis in patients undergoing abdominal surgery. Ibuprofen 44-53 interleukin 6 Homo sapiens 90-94 15240608-1 2004 Testosterone has immune-modulating properties, and current in vitro evidence suggests that testosterone may suppress the expression of the proinflammatory cytokines TNFalpha, IL-1beta, and IL-6 and potentiate the expression of the antiinflammatory cytokine IL-10. Testosterone 91-103 interleukin 6 Homo sapiens 189-193 15167223-7 2004 Many mechanisms are involved, including suppression of neoplastic transformation, cell growth inhibition, and enhanced apoptosis and anti-angiogenicity, through the inhibition of eicosanoid production from n-6 fatty acids; and suppression of cyclooxygenase 2 (COX-2), interleukin 1 (IL-1) and IL-6 gene expression by n-3 fatty acids. Eicosanoids 179-189 interleukin 6 Homo sapiens 293-297 15162378-6 2004 RESULTS: Exogenous IL-6 and anti-sense IL-6 oligonucleotide treatment conferred resistance to cytotoxic agent-induced apoptosis. Oligonucleotides 44-59 interleukin 6 Homo sapiens 39-43 15028733-6 2004 In fact, the unsaturated FFA linoleate inhibited palmitate-induced IL-6 production. Linoleic Acid 29-38 interleukin 6 Homo sapiens 67-71 14749206-5 2004 Twenty-four-week treatment with rosiglitazone (8 mg/day) compared with placebo significantly increased the expression of adiponectin, peroxisome proliferator-activated receptor-gamma (PPARgamma), and PPARgamma coactivator 1 and decreased IL-6 expression. Rosiglitazone 32-45 interleukin 6 Homo sapiens 238-242 15265271-5 2004 Treatment of cultured brain endothelial cells with inflammatory proteins (LPS, IL-1beta, IL-6, IFN-gamma, TNF-alpha) resulted in a significant increase (p < 0.01) in intracellular levels of reactive oxygen species by 1 h. Inflammatory proteins also caused release of tissue plasminogen activator and increased apoptosis by 24 h in these cells. Reactive Oxygen Species 190-213 interleukin 6 Homo sapiens 89-93 15194822-0 2004 Extracellular ATP induces oscillations of intracellular Ca2+ and membrane potential and promotes transcription of IL-6 in macrophages. Adenosine Triphosphate 14-17 interleukin 6 Homo sapiens 114-118 15194822-1 2004 The effects of low concentrations of extracellular ATP on cytosolic Ca(2+), membrane potential, and transcription of IL-6 were studied in monocyte-derived human macrophages. Adenosine Triphosphate 51-54 interleukin 6 Homo sapiens 117-121 15194822-7 2004 We also found that 10 microM ATP gamma S increased transcription of IL-6 approximately 40-fold within 2 h. This effect was abolished by blockade of P2Y receptors with 100 microM suramin. Adenosine Triphosphate 29-32 interleukin 6 Homo sapiens 68-72 15145616-1 2004 We assessed corticosteroid sensitivity in multiple sclerosis (MS) patients compared to control subjects, using an in vitro assay of dexamethasone (Dex) inhibition of lipopolysaccharide (LPS) stimulated-blood interleukin-6 production. Dexamethasone 132-145 interleukin 6 Homo sapiens 208-221 15135313-4 2004 When macrophages were primed with IFN-gamma, resveratrol suppressed the expression of HLA-ABC, HLA-DR, CD80, CD86 and inhibited production of TNF-alpha, IL-12, IL-6 and IL-1beta induced by LPS. Resveratrol 45-56 interleukin 6 Homo sapiens 160-164 15118463-7 2004 RESULTS: Latanoprost, pilocarpine-HCl, and timolol-maleate increased IL-6 levels in the conditioned medium in a dilution factor-dependent manner (P < 0.05, ANOVA). Timolol 43-58 interleukin 6 Homo sapiens 69-73 15232804-14 2004 IL-6 levels (pg/mL) were found to be lower in the sevoflurane group compared with controls at T2 arterial circulation (38.2 +/- 21.1 v 60.6 +/- 19.1, p < 0.05) as well as in the coronary circulation (38.4 +/- 19.9 v 118.2 +/- 23.5, p < 0.01) at T2. Sevoflurane 50-61 interleukin 6 Homo sapiens 0-4 15232804-19 2004 CONCLUSIONS: Sevoflurane decreases the inflammatory response after CPB, as measured by the release of IL-6, CD11b/CD18, and TNF-alpha. Sevoflurane 13-24 interleukin 6 Homo sapiens 102-106 15145616-2 2004 Significantly higher concentrations of dexamethasone were needed to obtain 50%-inhibition (ID(50)) of in vitro LPS stimulated interleukin (IL)-6 production (28.4 x 10(-7) M) in relapsing-remitting MS (RRMS) patients compared to chronic progressive MS (CPMS) patients (6.2 x 10(-7) M) or compared to controls (3.0 x 10(-7) M). Dexamethasone 39-52 interleukin 6 Homo sapiens 126-144 15109670-4 2004 A preliminary SAR study suggested that the hydrochloride of the CEFG-ring portion is an active pharmacophore for suppressing the growth of interleukin-6-dependent MH60 cells. hydrochloride 43-56 interleukin 6 Homo sapiens 139-152 15163536-6 2004 To our knowledge, this is the first report on native carbohydrates of a helminth parasite stimulating mammalian innate immune cells to produce a Th-2 polarizing cytokine (IL-6) via a Toll-like receptor. Carbohydrates 53-66 interleukin 6 Homo sapiens 171-175 15282657-7 2004 In a multiple logistic regression model that included inflammatory markers and clinical risk factors, antibodies to PF4/heparin were a strong predictor of 30-day MI (odds ratio, 9.0; 95% confidence intervals, 2.1 to 38.6; p < 0.01), with IL-6 being the only other predictor (odds ratio, 1.1; 95% confidence intervals, 1.0 to 1.2; p = 0.03). Heparin 120-127 interleukin 6 Homo sapiens 241-245 15102517-7 2004 Monocyte glucocorticoid sensitivity was defined as the dexamethasone concentration inhibiting IL-6 release by 50%. Dexamethasone 55-68 interleukin 6 Homo sapiens 94-98 15010462-2 2004 In this report we show that Grb2-associated binder (Gab) family adapter proteins Gab1 and Gab2 are expressed by multiple myeloma cells; and that interleukin-6 induces their tyrosine phosphorylation and association with downstream signaling molecules. Tyrosine 173-181 interleukin 6 Homo sapiens 145-158 15001458-5 2004 Inhibition of IL-6 using a neutralizing antibody significantly reduced glucose-mediated monocyte adhesion by 50%, and addition of IL-6 directly to human EC stimulated monocyte adhesion. Glucose 71-78 interleukin 6 Homo sapiens 14-18 15135803-2 2004 We examined the hypothesis that progesterone but not 17beta-estradiol (E) increases the secretion of pro-inflammatory cytokines interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha. Progesterone 32-44 interleukin 6 Homo sapiens 128-146 15033544-10 2004 TNF-alpha and IL-1beta presented a maximum response after 1h treatment, while IL-6 and IL-8 maximum response was after 3h treatment. Tritium 119-121 interleukin 6 Homo sapiens 78-82 15033544-16 2004 These data indicate that, Cd-induced TNF-alpha and IL-1beta, that probably, activate AP-1 transcription factor and IL-6 and IL-8 were induced. Cadmium 26-28 interleukin 6 Homo sapiens 115-119 15168319-2 2004 This study was conducted to determine if treatment with the antioxidant melatonin would influence interleukin-6, interleukin-8, tumor necrosis factor alpha, and nitrite/nitrate levels in newborns with grade III or IV respiratory distress syndrome (radiographically confirmed) diagnosed within the first 6 hours of life. Melatonin 72-81 interleukin 6 Homo sapiens 98-111 15168319-5 2004 Compared with the melatonin-treated respiratory distress syndrome newborns, in the untreated infants the concentrations of interleukin-6, interleukin-8, and tumor necrosis factor alpha were significantly higher at 24 hours, 72 hours, and at 7 days after onset of the study. Melatonin 18-27 interleukin 6 Homo sapiens 123-136 14749354-0 2004 Synergistic induction of the nicotinamide adenine dinucleotide-linked 15-hydroxyprostaglandin dehydrogenase by an androgen and interleukin-6 or forskolin in human prostate cancer cells. NAD 29-62 interleukin 6 Homo sapiens 127-140 14751542-0 2004 PKA-dependent activation of PKC, p38 MAPK and IKK in macrophage: implication in the induction of inducible nitric oxide synthase and interleukin-6 by dibutyryl cAMP. Cyclic AMP 160-164 interleukin 6 Homo sapiens 133-146 15136366-8 2004 CONCLUSION: Patients recovering from ACS had lower levels of CRP and IL-6 at 1 month and lower CRP levels at 3 months when treated with rofecoxib plus aspirin. Aspirin 151-158 interleukin 6 Homo sapiens 69-73 15066049-3 2004 Previously, we found that melatonin reduced the rises in proinflammatory cytokines (IL-6, IL-8 and TNF-alpha) and nitrite/nitrate levels in the serum of preterm newborns with respiratory distress syndrome (RDS). Melatonin 26-35 interleukin 6 Homo sapiens 84-88 15209363-6 2004 IJAE inhibited the secretion of tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated human mast cell line (HMC-1) cells. Tetradecanoylphorbol Acetate 98-129 interleukin 6 Homo sapiens 76-94 15209363-6 2004 IJAE inhibited the secretion of tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated human mast cell line (HMC-1) cells. Calcium 141-148 interleukin 6 Homo sapiens 76-94 15094775-5 2004 Moreover, inhibition of CDC34 enzymatic activity abrogates interleukin-6-induced protection against Dex-induced apoptosis. Dexamethasone 100-103 interleukin 6 Homo sapiens 59-72 14998552-7 2004 SB203580 and PD98059 decreased LPS-induced gene expression of IL-1beta and IL-6. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 interleukin 6 Homo sapiens 75-79 15294041-4 2004 It has been demonstrated that IL-6 has many biological roles such as: (1) induction of lipolysis; (2) suppression of TNF production; (3) stimulation of cortisol production. Hydrocortisone 152-160 interleukin 6 Homo sapiens 30-34 15294041-6 2004 In addition, carbohydrate supplementation during exercise has been shown to inhibit the release of IL-6 from contracting muscle. Carbohydrates 13-25 interleukin 6 Homo sapiens 99-103 14754894-7 2004 Most importantly, treatment with IL-6-neutralizing antibody dramatically reduced the cAMP-induced GFAP expression and STAT3 phosphorylation and reversed the cellular morphological changes that had been caused by Bt(2)AMP/theophylline. Cyclic AMP 85-89 interleukin 6 Homo sapiens 33-37 15070696-8 2004 Strikingly, the combinatorial treatment with rapamycin and dexamethasone suppressed the antiapoptotic effects of exogenously added IGF-I and interleukin 6 (IL-6) as well as their stimulation of p70S6K phosphorylation. Sirolimus 45-54 interleukin 6 Homo sapiens 141-154 15070696-8 2004 Strikingly, the combinatorial treatment with rapamycin and dexamethasone suppressed the antiapoptotic effects of exogenously added IGF-I and interleukin 6 (IL-6) as well as their stimulation of p70S6K phosphorylation. Sirolimus 45-54 interleukin 6 Homo sapiens 156-160 15070696-8 2004 Strikingly, the combinatorial treatment with rapamycin and dexamethasone suppressed the antiapoptotic effects of exogenously added IGF-I and interleukin 6 (IL-6) as well as their stimulation of p70S6K phosphorylation. Dexamethasone 59-72 interleukin 6 Homo sapiens 141-154 15070696-8 2004 Strikingly, the combinatorial treatment with rapamycin and dexamethasone suppressed the antiapoptotic effects of exogenously added IGF-I and interleukin 6 (IL-6) as well as their stimulation of p70S6K phosphorylation. Dexamethasone 59-72 interleukin 6 Homo sapiens 156-160 15087402-9 2004 In addition, SGN-40 pretreatment of MM.1S cells blocked the ability of IL-6 to protect against Dex-induced inhibition of DNA synthesis. Dexamethasone 95-98 interleukin 6 Homo sapiens 71-75 15050609-0 2004 Light/dark patterns of interleukin-6 in relation to the pineal hormone melatonin in patients with acute myocardial infarction. Melatonin 71-80 interleukin 6 Homo sapiens 23-36 15050609-3 2004 Melatonin is mainly released during the night, but the precise relationship between melatonin and the light/dark rhythm of interleukin-6 in patients with acute myocardial infarction is still unclear. Melatonin 84-93 interleukin 6 Homo sapiens 123-136 15050609-7 2004 CONCLUSIONS: The current findings suggest that the circadian secretion of melatonin may be responsible at least in part for light/dark variations of endogenous interleukin-6 production in patients with acute myocardial infarction. Melatonin 74-83 interleukin 6 Homo sapiens 160-173 15015204-10 2004 In the case of Ni(II), potentiation of TNFalpha, IL1beta, and IL6 ranged from 200% for TNFalpha to over 1200% for IL6. Nickel(2+) 15-21 interleukin 6 Homo sapiens 62-65 15015204-10 2004 In the case of Ni(II), potentiation of TNFalpha, IL1beta, and IL6 ranged from 200% for TNFalpha to over 1200% for IL6. Nickel(2+) 15-21 interleukin 6 Homo sapiens 114-117 14754894-0 2004 cAMP-induced astrocytic differentiation of C6 glioma cells is mediated by autocrine interleukin-6. Cyclic AMP 0-4 interleukin 6 Homo sapiens 84-97 14754894-2 2004 In this report, we show that cAMP-induced autocrine interleukin 6 (IL-6) promoted astrocytic differentiation of C6 cells. Cyclic AMP 29-33 interleukin 6 Homo sapiens 67-71 15282117-1 2004 In the current study, our aim was to evaluate and investigate the influence of heavy alcohol intake on serum interleukin (IL)-6, IL-8, IL-10, IL-12, and tumor necrosis factor-alpha (TNF-alpha) concentrations. Alcohols 85-92 interleukin 6 Homo sapiens 109-127 15282117-7 2004 These results indicate that in alcohol-dependent individuals there is a significant increase in the serum IL-6 concentration (P <.05). Alcohols 31-38 interleukin 6 Homo sapiens 106-110 15039004-6 2004 Glucocorticoid (GC) sensitivity was measured by dexamethasone (DEX) inhibition of lipopolysaccharide (LPS)-induced interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) production in whole blood. Dexamethasone 48-61 interleukin 6 Homo sapiens 115-128 15039004-6 2004 Glucocorticoid (GC) sensitivity was measured by dexamethasone (DEX) inhibition of lipopolysaccharide (LPS)-induced interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) production in whole blood. Dexamethasone 48-61 interleukin 6 Homo sapiens 130-134 15039004-6 2004 Glucocorticoid (GC) sensitivity was measured by dexamethasone (DEX) inhibition of lipopolysaccharide (LPS)-induced interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) production in whole blood. Dexamethasone 63-66 interleukin 6 Homo sapiens 115-128 15039004-6 2004 Glucocorticoid (GC) sensitivity was measured by dexamethasone (DEX) inhibition of lipopolysaccharide (LPS)-induced interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) production in whole blood. Dexamethasone 63-66 interleukin 6 Homo sapiens 130-134 15039004-8 2004 Less DEX was required for cytokine suppression in PTSD patients (IL-6: t = -2.82, p =.01; TNF-alpha: t = 5.03, p <.001), reflecting higher GC sensitivity of pro-inflammatory cytokine production. Dexamethasone 5-8 interleukin 6 Homo sapiens 65-69 14999749-5 2004 Addition of titanium particles increased release of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1 beta). Titanium 12-20 interleukin 6 Homo sapiens 93-106 15219461-0 2004 Inhibition of IL-6, TNF-alpha, and cyclooxygenase-2 protein expression by prostaglandin E2-induced IL-10 in bone marrow-derived dendritic cells. Dinoprostone 74-90 interleukin 6 Homo sapiens 14-18 15057738-1 2004 BACKGROUND & AIMS: Interleukin-6 (IL-6) regulates immune response and inflammation. Adenosine Monophosphate 12-15 interleukin 6 Homo sapiens 23-36 15057738-1 2004 BACKGROUND & AIMS: Interleukin-6 (IL-6) regulates immune response and inflammation. Adenosine Monophosphate 12-15 interleukin 6 Homo sapiens 38-42 15093992-9 2004 In the group of unstable angina patients, we observed a statistically significant reduction in the levels of MMP-9, TIMP-1 and IL-6 after the 30-day atorvastatin administration. Atorvastatin 149-161 interleukin 6 Homo sapiens 127-131 15093994-8 2004 IL-6 plasma levels, but not IL-10 concentrations, correlated significantly with 8-iso-PGF2alpha levels in urine. 8-epi-prostaglandin F2alpha 80-95 interleukin 6 Homo sapiens 0-4 15093994-10 2004 Inflammatory cytokine IL-6, but not anti-inflammatory cytokine Il-10, levels correlated significantly with the oxygen stress index. Oxygen 111-117 interleukin 6 Homo sapiens 22-26 15005841-10 2004 In contrast, p values (0.003-0.096 by ANOVA) suggestive of an interaction between IL-6 -174 genotypes and years since menopause, estrogen status, dietary calcium, and vitamin D intake were observed in women (n = 819). Vitamin D 167-176 interleukin 6 Homo sapiens 82-86 15005841-14 2004 In conclusion, IL-6 genetic variation was prominently associated with hip BMD in late postmenopausal women, those without estrogen replacement therapy, and those with inadequate calcium intake. Calcium 178-185 interleukin 6 Homo sapiens 15-19 15219461-7 2004 Taken together, our results show that in response to PGE(2), BM-DC produce IL-10, which in turn down-regulates their own production of IL-6-, TNF-alpha-, and COX-2-derived prostanoids, and plays crucial roles in determining the BM-DC pro-inflammatory phenotype. Prostaglandins 172-183 interleukin 6 Homo sapiens 135-139 15379216-5 2004 Ozone exposure (3.0 ppm, 3 min) time-dependently changed the redox state, while increasing production of interleukin(IL)-8 and IL-6, mRNA and protein. Ozone 0-5 interleukin 6 Homo sapiens 127-131 15379216-6 2004 Treatment with GSH-OEt before ozone suppressed IL-8, but stimulated IL-6 production. S-ethyl glutathione 15-22 interleukin 6 Homo sapiens 68-72 14999749-5 2004 Addition of titanium particles increased release of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1 beta). Titanium 12-20 interleukin 6 Homo sapiens 108-112 16145911-4 2004 The concentrations of PGE2 and IL-6 in supernates of atorvastatin intervention groups at different levels were significantly lower than those in non-intervention group (P < 0.05). Atorvastatin 53-65 interleukin 6 Homo sapiens 31-35 15051824-6 2004 Quercetin reduced linoleic acid-mediated binding activity of NF-kappaB and AP-1 and mRNA levels of inflammatory genes such as interleukin-6 (IL-6) and vascular cell adhesion molecule-1 (VCAM-1). Linoleic Acid 18-31 interleukin 6 Homo sapiens 141-145 15072174-10 2004 Ibuprofen suppressed sputum-stimulated IL-6 production to levels above control and effect levelled off at 50-100 microg/mi, contrasting the dose-dependent suppression to control level with MK-663 (0.1-10 microg/ml) and to sub-control levels with triptolide (20-1000 ng/ml). Ibuprofen 0-9 interleukin 6 Homo sapiens 39-43 16145911-0 2004 [Effects of atorvastatin on LPS-induced PGE2 and IL-6 secretions in human pulmonary epithelial cells]. Atorvastatin 12-24 interleukin 6 Homo sapiens 49-53 16145911-1 2004 OBJECTIVE: To investigate the effects of atorvastatin on LPS-induced PGE2 and IL-6 secretions in human pulmonary epithelial cells (A549). Atorvastatin 41-53 interleukin 6 Homo sapiens 78-82 15051033-0 2004 The regulation of interleukin-6 secretion by prostanoids and members of the tumor necrosis factor superfamily in fresh villous fragments of term human placenta. Prostaglandins 45-56 interleukin 6 Homo sapiens 18-31 15051033-1 2004 OBJECTIVE: To determine whether prostanoids, nonsteroidal anti-inflammatory drugs (NSAIDs), and members of the tumor necrosis factor superfamily can regulate placental secretion of interleukin-6 (IL-6) and whether labor influences any such effects. Prostaglandins 32-43 interleukin 6 Homo sapiens 181-194 15051033-11 2004 CONCLUSION: Prostanoids, NSAIDs, and the Fas ligand regulate placental IL-6 secretion. Prostaglandins 12-23 interleukin 6 Homo sapiens 71-75 15160951-4 2004 The purpose of the combination therapy was to sensitize the myeloma cells with ATRA to chemotherapy by blocking the growth-promoting effect of IL-6. Tretinoin 79-83 interleukin 6 Homo sapiens 143-147 15160951-10 2004 There may be some beneficial effect of ATRA in combination chemotherapy in selected patients who have activated IL-6 signaling. Tretinoin 39-43 interleukin 6 Homo sapiens 112-116 16145911-5 2004 CONCLUSION: Atorvastatin decreased LPS-induced PGE2 and IL-6 secretions in human pulmonary epithelial cells (A549), which suggests that statins have anti-inflammatory properties on human pulmonary epithelial cells. Atorvastatin 12-24 interleukin 6 Homo sapiens 56-60 15080015-7 2004 The parallel increase in creatinine kinase concentration and A-a oxygen gradient indicates that IL-6 plays an important role in acute arterial occlusion and reperfusion injury. Oxygen 65-71 interleukin 6 Homo sapiens 96-100 14981536-5 2004 Furthermore, we showed that IL6 downstream tyrosine kinase Etk can induce tyrosine phosphorylation of Pim1 which is correlated with its kinase activity. Tyrosine 43-51 interleukin 6 Homo sapiens 28-31 14984727-2 2004 Pentoxifylline, a xanthin-derived agent, is known to inhibit the production of TNF-alpha and IL-6. Xanthine 18-25 interleukin 6 Homo sapiens 93-97 14712497-0 2004 Enhanced radiosensitization and chemosensitization in NF-kappaB-suppressed human oral cancer cells via the inhibition of gamma-irradiation- and 5-FU-induced production of IL-6 and IL-8. Fluorouracil 144-148 interleukin 6 Homo sapiens 171-175 14712497-7 2004 ELISA analysis indicated that although a remarkable increase in production of IL-6 and IL-8 was observed in B88 and B88neo after in vitro exposure to IR or treatment with 5-FU, radiotherapy and chemotherapy-induced production of these cytokines was significantly suppressed in B88mI cell clones. Fluorouracil 171-175 interleukin 6 Homo sapiens 78-82 14634061-0 2004 Acute ethanol exposure inhibits macrophage IL-6 production: role of p38 and ERK1/2 MAPK. Ethanol 6-13 interleukin 6 Homo sapiens 43-47 14634061-5 2004 We demonstrated that a single dose of ethanol transiently down-regulated p38 and ERK1/2 activation levels (3-24 h after treatment) and impaired IL-6 synthesis. Ethanol 38-45 interleukin 6 Homo sapiens 144-148 14634061-7 2004 These results demonstrate that acute ethanol exposure can impair macrophage IL-6 production and indicate that this effect may result from ethanol-induced alterations in intracellular signaling through p38 and ERK1/2. Ethanol 37-44 interleukin 6 Homo sapiens 76-80 14634061-7 2004 These results demonstrate that acute ethanol exposure can impair macrophage IL-6 production and indicate that this effect may result from ethanol-induced alterations in intracellular signaling through p38 and ERK1/2. Ethanol 138-145 interleukin 6 Homo sapiens 76-80 14617690-7 2004 Furthermore, AGI-1067 inhibited the inducible expression of the redox-sensitive genes, vascular cell adhesion molecule-1 (VCAM-1) and monocyte chemoattractant protein-1, in endothelial cells as well as tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, and IL-6 production in peripheral blood mononuclear cells, whereas probucol had no effect. succinobucol 13-21 interleukin 6 Homo sapiens 271-275 15074399-0 2004 Alcohol modulates circulating levels of interleukin-6 and monocyte chemoattractant protein-1 in chronic pancreatitis. Alcohols 0-7 interleukin 6 Homo sapiens 40-53 14737074-2 2004 We found that the treatment with MAP/ERK kinase 1 (MEK1) inhibitors PD98059 or PD184352 produced a reduction of phosphorylated ERK1/2 (p-ERK1/2) levels in myeloma cells of more than 80% and prevented the increase of p-ERK1/2 induced by interleukin-6 (IL-6). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 68-75 interleukin 6 Homo sapiens 236-249 14737074-2 2004 We found that the treatment with MAP/ERK kinase 1 (MEK1) inhibitors PD98059 or PD184352 produced a reduction of phosphorylated ERK1/2 (p-ERK1/2) levels in myeloma cells of more than 80% and prevented the increase of p-ERK1/2 induced by interleukin-6 (IL-6). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 68-75 interleukin 6 Homo sapiens 251-255 15015143-11 2004 Plasma IL-6 levels at 6 hours (r =.631, P =.02) were correlated significantly with plasma alcohol levels at 1 hour after ingestion of red wine. Alcohols 90-97 interleukin 6 Homo sapiens 7-11 15015143-13 2004 It is possible that this increase in plasma IL-6 is a response to alcohol-induced oxidative stress in the liver. Alcohols 66-73 interleukin 6 Homo sapiens 44-48 14982601-6 2004 Stretch-induced IL-8 and IL-6 production were significantly inhibited when intracellular GSH was further increased by NAC or GSH-e (P < 0.0001). Glutathione 89-92 interleukin 6 Homo sapiens 25-29 14982601-6 2004 Stretch-induced IL-8 and IL-6 production were significantly inhibited when intracellular GSH was further increased by NAC or GSH-e (P < 0.0001). Acetylcysteine 118-121 interleukin 6 Homo sapiens 25-29 14982601-6 2004 Stretch-induced IL-8 and IL-6 production were significantly inhibited when intracellular GSH was further increased by NAC or GSH-e (P < 0.0001). gsh-e 125-130 interleukin 6 Homo sapiens 25-29 14982601-7 2004 Stretch-induced IL-8 and IL-6 production were augmented when intracellular GSH was depleted by BSO (P < 0.0001). Glutathione 75-78 interleukin 6 Homo sapiens 25-29 15074399-5 2004 RESULTS: IL-6 was higher in CP at fasting and 1, 4 and 24 h after alcohol intake (P < 0.04), and a significantly greater rise was found at 1 h compared to pre-stimulatory conditions and controls (P < 0.01). Alcohols 66-73 interleukin 6 Homo sapiens 9-13 15074399-8 2004 CONCLUSIONS: Acute alcohol intake induces a rise in the plasma levels of IL-6 in CP as compared to controls. Alcohols 19-26 interleukin 6 Homo sapiens 73-77 14970177-4 2004 Although hIL-6 is also N-glycosylated at N73 and multiply O-glycosylated, neither N-linked nor O-linked glycosylation is necessary for IL-6 receptor alpha-dependent binding to gp130 or signaling through JAK1-STAT1/3. Nitrogen 23-24 interleukin 6 Homo sapiens 9-14 14551144-9 2004 We show that in mature PDCs adenosine reduces interleukin-6 (IL-6), IL-12, and IFN-alpha production in response to CpG oligodeoxynucleotides (ODN). Adenosine 28-37 interleukin 6 Homo sapiens 46-59 14676217-0 2004 High glucose enhances interleukin-6-induced vascular endothelial growth factor 165 expression via activation of gp130-mediated p44/42 MAPK-CCAAT/enhancer binding protein signaling in gingival fibroblasts. Glucose 5-12 interleukin 6 Homo sapiens 22-35 14676217-2 2004 Our purpose was to determine the effect of a high glucose (HG) condition on the interleukin-6/soluble interleukin-6 receptor (IL-6/sIL-6R)-induced activation of signaling and vascular endothelial growth factor (VEGF) expression in human gingival fibroblasts (HGFs). Glucose 50-57 interleukin 6 Homo sapiens 80-93 14676217-2 2004 Our purpose was to determine the effect of a high glucose (HG) condition on the interleukin-6/soluble interleukin-6 receptor (IL-6/sIL-6R)-induced activation of signaling and vascular endothelial growth factor (VEGF) expression in human gingival fibroblasts (HGFs). Glucose 50-57 interleukin 6 Homo sapiens 126-130 14676217-5 2004 Consistent with the expression of its mRNA, the HG condition also increased the expression of gp130 protein, and phosphorylation of the tyrosine residue by gp130 was enhanced significantly by IL-6/sIL-6R stimulation. Tyrosine 136-144 interleukin 6 Homo sapiens 192-196 14551144-9 2004 We show that in mature PDCs adenosine reduces interleukin-6 (IL-6), IL-12, and IFN-alpha production in response to CpG oligodeoxynucleotides (ODN). Adenosine 28-37 interleukin 6 Homo sapiens 61-65 14970177-4 2004 Although hIL-6 is also N-glycosylated at N73 and multiply O-glycosylated, neither N-linked nor O-linked glycosylation is necessary for IL-6 receptor alpha-dependent binding to gp130 or signaling through JAK1-STAT1/3. Nitrogen 23-24 interleukin 6 Homo sapiens 10-14 14970177-4 2004 Although hIL-6 is also N-glycosylated at N73 and multiply O-glycosylated, neither N-linked nor O-linked glycosylation is necessary for IL-6 receptor alpha-dependent binding to gp130 or signaling through JAK1-STAT1/3. Nitrogen 41-42 interleukin 6 Homo sapiens 9-14 14970177-4 2004 Although hIL-6 is also N-glycosylated at N73 and multiply O-glycosylated, neither N-linked nor O-linked glycosylation is necessary for IL-6 receptor alpha-dependent binding to gp130 or signaling through JAK1-STAT1/3. Nitrogen 41-42 interleukin 6 Homo sapiens 10-14 14970177-6 2004 These findings highlight distinct functional roles of N-linked glycosylation in viral and cellular IL-6. Nitrogen 54-55 interleukin 6 Homo sapiens 99-103 14563701-0 2004 Involvement of cholesterol-rich lipid rafts in interleukin-6-induced neuroendocrine differentiation of LNCaP prostate cancer cells. Cholesterol 15-26 interleukin 6 Homo sapiens 47-60 14769682-6 2004 After adjustment for age, race, smoking status, history of diabetes, history of cardiovascular disease, physical activity, high-density lipoprotein cholesterol, antiinflammatory medications, statins, and total fat mass, alcohol intake showed a J-shaped relationship with mean IL-6 (P for quadratic term <0.001) and CRP (P=0.014) levels. Alcohols 220-227 interleukin 6 Homo sapiens 276-280 14769682-10 2004 CONCLUSIONS: In well-functioning older persons, light alcohol consumption is associated with lower levels of IL-6 and CRP. Alcohols 54-61 interleukin 6 Homo sapiens 109-113 14698135-10 2004 In the every 3-week paclitaxel group, IL-6 and IL-8 increased whereas in the weekly paclitaxel group IL-10 increased significantly compared to baseline. Paclitaxel 20-30 interleukin 6 Homo sapiens 38-42 14717786-0 2004 The effects of selective cytokine inhibitory drugs (CC-10004 and CC-1088) on VEGF and IL-6 expression and apoptosis in myeloma and endothelial cell co-cultures. apremilast 52-60 interleukin 6 Homo sapiens 86-90 14726660-2 2004 Myeloma cells resist Dexamethasone induced apoptosis when exposed to IL-6 or IGF-1, both of which are known to activate several signaling cascades. Dexamethasone 21-34 interleukin 6 Homo sapiens 69-73 14726660-3 2004 For the first time, we show the actual contribution of downstream mediators, i.e., activated STAT factors, independent of the contribution of their upstream signaling pathways, on the proliferation and Dexamethasone rescue effects of IL-6 and IGF-1 in Multiple Myeloma. Dexamethasone 202-215 interleukin 6 Homo sapiens 234-238 14975222-0 2004 Effects of morphine and fentanyl on tumor necrosis factor-alpha and interleukin-6 concentrations in human whole blood in vitro. Morphine 11-19 interleukin 6 Homo sapiens 68-81 14975053-9 2004 At 6 hours the IL-6 concentration was significantly lower in the ceftazidime group than in the saline group (P < 0.05), and in both the ceftazidime and the tobramycin groups there were significantly greater reductions from peak values (P < 0.05). Sodium Chloride 95-101 interleukin 6 Homo sapiens 15-19 14975242-3 2004 Here we demonstrate that expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in MM cells and its agonists 15-d-PGJ2 and troglitazone completely abolished IL-6-inducible MM cell proliferation and induced apoptosis through affecting expression of multiple cell cycle or apoptosis genes, whereas PPARgamma antagonist GW9662 and PPARalpha agonist WY14643 did not display this inhibitory effect. 15-deoxyprostaglandin J2 129-138 interleukin 6 Homo sapiens 177-181 14966737-12 2004 In group 1a the immediate postoperative values of cytokines were significantly higher than group 1b and group 2, but a significant improvement was observed after administration of melatonin with significantly lower levels of IL-6 and IL-8 with respect to group 2. Melatonin 180-189 interleukin 6 Homo sapiens 225-229 14996410-4 2004 imipramine and venlafaxine (at the higher concentration), 5-HTP (at lower and higher concentrations) and a combination of 5-HTP and fluoxetine (both at the lower concentration) increased the production of IL-6; (2). Imipramine 0-10 interleukin 6 Homo sapiens 205-209 14706622-6 2004 Western immunoblotting and indirect cellular immunofluorescence showed that indomethacin and ibuprofen induce Hsc70 nuclear translocation at concentrations previously shown to induce HSF DNA-binding activity. Ibuprofen 93-102 interleukin 6 Homo sapiens 183-186 14742690-11 2004 Aspirin also enhanced steady-state mRNA levels of other IL-1 modulated genes (IL-1beta, IL-6, groalpha, and TNFalpha) that are likewise regulated at the level of message stability via p38 activation. Aspirin 0-7 interleukin 6 Homo sapiens 88-92 12969979-8 2004 Gene expression profiling of INA-6 cells by using oligonucleotide microarrays revealed many novel IL-6 target genes, among them several genes coding for transcriptional regulators involved in B-lymphocyte differentiation as well as for growth factors and receptors potentially implicated in autocrine or paracrine growth control. Oligonucleotides 50-65 interleukin 6 Homo sapiens 98-102 12974672-1 2004 Signal transducer and activator of transcription 3 (Stat3) dimerization is commonly thought to be triggered by its tyrosine phosphorylation in response to interleukin-6 (IL-6) or other cytokines. Tyrosine 115-123 interleukin 6 Homo sapiens 155-168 12974672-1 2004 Signal transducer and activator of transcription 3 (Stat3) dimerization is commonly thought to be triggered by its tyrosine phosphorylation in response to interleukin-6 (IL-6) or other cytokines. Tyrosine 115-123 interleukin 6 Homo sapiens 170-174 12974672-7 2004 IL-6 induced a 2-fold increase of this basal FRET signal, indicating that tyrosine phosphorylation either increases the dimer/monomer ratio of Stat3 or induces a conformational change of the dimer yielding a higher FRET efficiency. Tyrosine 74-82 interleukin 6 Homo sapiens 0-4 12855406-9 2004 Thus, Ado increases the release of interleukin-6 and monocyte chemotactic protein-1 from bronchial smooth muscle cells via activation of the A2B AdoR. Adenosine 6-9 interleukin 6 Homo sapiens 35-48 15384786-8 2004 In EG, dialysate-to-plasma creatinine at 4 hours (D/P(Cr240)) correlated significantly with effluent CA125/min (r = 0.51, p = 0.006) and VEGF/min (r = 0.57, p = 0.001), but not with serum VEGF or IL-6. Creatinine 27-37 interleukin 6 Homo sapiens 196-200 15384786-8 2004 In EG, dialysate-to-plasma creatinine at 4 hours (D/P(Cr240)) correlated significantly with effluent CA125/min (r = 0.51, p = 0.006) and VEGF/min (r = 0.57, p = 0.001), but not with serum VEGF or IL-6. cr240 54-59 interleukin 6 Homo sapiens 196-200 14758567-0 2004 Estradiol stimulates vascular endothelial growth factor and interleukin-6 in human lactotroph and lactosomatotroph pituitary adenomas. Estradiol 0-9 interleukin 6 Homo sapiens 60-73 14651947-1 2004 Effects of three experimental manipulations: mental stress, relaxation, and a nociceptive inflammatory stimulus, capsaicin, on levels of interleukin-6 (IL-6) were examined. Capsaicin 113-122 interleukin 6 Homo sapiens 137-150 14651947-1 2004 Effects of three experimental manipulations: mental stress, relaxation, and a nociceptive inflammatory stimulus, capsaicin, on levels of interleukin-6 (IL-6) were examined. Capsaicin 113-122 interleukin 6 Homo sapiens 152-156 14651947-6 2004 Small but significant increases in IL-6 were seen at 60 min post-capsaicin. Capsaicin 65-74 interleukin 6 Homo sapiens 35-39 15663358-3 2004 Factors such as IL-6, epinephrine, and forskolin induce NE differentiation in prostate cancer cells; the mechanisms involve increases in intracellular cAMP, protein kinase A (PKA) activation and reduced intracellular calcium levels. Cyclic AMP 151-155 interleukin 6 Homo sapiens 16-20 15663358-3 2004 Factors such as IL-6, epinephrine, and forskolin induce NE differentiation in prostate cancer cells; the mechanisms involve increases in intracellular cAMP, protein kinase A (PKA) activation and reduced intracellular calcium levels. Calcium 217-224 interleukin 6 Homo sapiens 16-20 14758567-7 2004 In cell cultures obtained from tumors from which sufficient cells could be isolated, a dose-dependent effect of estradiol (1 to 100 nM) on VEGF and IL-6 production was observed. Estradiol 112-121 interleukin 6 Homo sapiens 148-152 15053241-11 2004 In stroke patients, but not in controls, IL-6 level correlated significantly with cortisol level and morning serum IL-6 level independently predicted evening/night cortisol level. Hydrocortisone 82-90 interleukin 6 Homo sapiens 41-45 15055740-7 2004 A significantly higher production of IL-6 was found in both unstimulated and stimulated PBL from heroin addicts and patients maintained on methadone, when compared with PBL from healthy controls. Methadone 139-148 interleukin 6 Homo sapiens 37-41 14979481-9 2004 In CD45+ U266 cells, IL-6 increased tyrosine phosphorylation of gp130 and STAT3 and stimulated the level of Mcl-1 protein expression. Tyrosine 36-44 interleukin 6 Homo sapiens 21-25 15373964-10 2004 Since fever induced by IL-1, TNF-alpha, IL-6 or TLR ligands requires cyclooxygenase-2, production of prostaglandin E2 (PGE2) and activation of hypothalamic PGE2 receptors provides a unifying mechanism for fever by endogenous and exogenous pyrogens. Dinoprostone 119-123 interleukin 6 Homo sapiens 40-44 15373964-10 2004 Since fever induced by IL-1, TNF-alpha, IL-6 or TLR ligands requires cyclooxygenase-2, production of prostaglandin E2 (PGE2) and activation of hypothalamic PGE2 receptors provides a unifying mechanism for fever by endogenous and exogenous pyrogens. Dinoprostone 101-117 interleukin 6 Homo sapiens 40-44 15082113-3 2004 In turn, histamine and nitric oxide are positive regulatory factors for Il-6. Histamine 9-18 interleukin 6 Homo sapiens 72-76 14688319-6 2004 Furthermore, NK cells respond to poly(I:C) by producing proinflammatory cytokines like IL-6 and IL-8, as well as the antiviral cytokine IFN-gamma. Carbon 40-41 interleukin 6 Homo sapiens 87-91 15022609-5 2004 Decreasing concentrations of IL-1, IL-6, TNF-alpha and INF-gamma in IDA patients due to an adequate therapy by iron-containing drugs is a positive phenomenon in recovering the functional status of the immune system; it denotes that the maturation of hemoglobin-containing erythron variations and the secondary immune insufficiency are reviving. Iron 111-115 interleukin 6 Homo sapiens 35-39 15485092-5 2004 Thus, available steroid prehormones are rapidly converted to proinflammatory estrogens in the synovial tissue in the presence of inflammatory cytokines (i.e., TNFalpha, IL-1, IL-6). Steroids 16-23 interleukin 6 Homo sapiens 175-179 14694519-5 2004 In paraffin sections, cells that expressed IL-6 or MCP-1 were identified by combined in situ hybridization and immunohistochemistry. Paraffin 3-11 interleukin 6 Homo sapiens 43-47 15236798-5 2004 A recent study shows that nitric oxide suppresses the activation of Stat3 by interleukin-6 in hepatocytes; Stat3 is crucial for the IL-6-mediated induction of CRP and various other acute phase reactants. Nitric Oxide 26-38 interleukin 6 Homo sapiens 77-90 15082113-3 2004 In turn, histamine and nitric oxide are positive regulatory factors for Il-6. Nitric Oxide 23-35 interleukin 6 Homo sapiens 72-76 15236798-5 2004 A recent study shows that nitric oxide suppresses the activation of Stat3 by interleukin-6 in hepatocytes; Stat3 is crucial for the IL-6-mediated induction of CRP and various other acute phase reactants. Nitric Oxide 26-38 interleukin 6 Homo sapiens 132-136 14678569-11 2003 Pre-treatment with low doses of DMBA or TCDD selectively abrogated IL-6 gene induction but had no effect on LIF mRNA. Polychlorinated Dibenzodioxins 40-44 interleukin 6 Homo sapiens 67-71 15046557-5 2004 Conversely, TNF-alpha, IL-6, and IL-8 increased reactive oxygen species production and the expression of CD11b and CD15 on both neutrophils and monocytes and decreased the expression of CD62L. Reactive Oxygen Species 48-71 interleukin 6 Homo sapiens 23-27 14671038-11 2004 Dexamethasone significantly inhibited the cytokine-induced IL-6 protein release in PTC, but not in DTC. Dexamethasone 0-13 interleukin 6 Homo sapiens 59-63 14678569-12 2003 Real-time-PCR indicated a significant inhibition of IL-6 mRNA by AhR ligands within 1 hour of LPS challenge which was reflected in a profound down-regulation of IL-6 protein induction, with DMBA and TCDD suppressing IL-6 levels as much as 65% and 88%, respectively. Polychlorinated Dibenzodioxins 199-203 interleukin 6 Homo sapiens 52-56 14723336-0 2003 Inhibition of IL-1beta and IL-6 in osteoblast-like cell by isoflavones extracted from Sophorae fructus. Isoflavones 59-70 interleukin 6 Homo sapiens 27-31 14723336-4 2003 Interestingly, IL-1beta and IL-6 mRNA were significantly suppressed in osteoblast-like cells treated with 17beta-estradiol (E2) and PIII when compared to positive control (SDB), and this suppression was more effective at 10(-8)% than at the highest concentration of 10(-4)%. Estradiol 106-122 interleukin 6 Homo sapiens 28-32 14615256-2 2003 The aim of this study was to evaluate the effect of the calcium antagonist verapamil on the interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) secretion, as well as on cellular growth, in primary cultures of fibroblasts derived from the central part of keloid lesions. Calcium 56-63 interleukin 6 Homo sapiens 92-105 14615256-2 2003 The aim of this study was to evaluate the effect of the calcium antagonist verapamil on the interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) secretion, as well as on cellular growth, in primary cultures of fibroblasts derived from the central part of keloid lesions. Calcium 56-63 interleukin 6 Homo sapiens 107-111 14974816-2 2003 PGE2 is important in regulating IL-6 production. Dinoprostone 0-4 interleukin 6 Homo sapiens 32-36 14636286-8 2003 RESULTS: In in vitro conditions iron induces a dose-dependent inhibition of viability of the mesothelial cells as reflected by inhibition of the cells growth by 34% at Fe 0.1 mg mL-1 vs. control (P < 0.05) increased release of lactate dehydrogenase (LDH) from the cytosol: 67.1 +/- 30.3 mU mL-1 at Fe 1 mg mL-1 vs. 7.9 +/- 6.4 in control group (P < 0.001), and reduced synthesis of IL-6: 209 +/- 378 pg mg-1 cell protein at Fe 1 mg mL-1 vs. 38674 +/- 4146 pg mg-1 cell protein in controls (P < 0.001). Iron 32-36 interleukin 6 Homo sapiens 388-392 14974816-10 2003 When exogenous PGE2 was added concurrently with COX-2 inhibitors before addition of IL-1beta, IL-6 production returned to levels at or approaching that produced by cells exposed only to IL-1beta (P < or = 0.04). Dinoprostone 15-19 interleukin 6 Homo sapiens 94-98 29539078-2 2003 PGE2 is important in regulating IL-6 production. Dinoprostone 0-4 interleukin 6 Homo sapiens 32-36 14625484-5 2003 Animals, receiving epinephrine therapy, showed a significantly prolonged upregulation of IL-6 mRNA expression at 4 h after LPS application in liver (P = 0.0014), spleen (P < 0.0001), and mesenteric lymph nodes (P = 0.0078) as compared with animals treated with norepinephrine or fluid resuscitation. Norepinephrine 264-278 interleukin 6 Homo sapiens 89-93 29539078-10 2003 When exogenous PGE2 was added concurrently with COX-2 inhibitors before addition of IL-1beta, IL-6 production returned to levels at or approaching that produced by cells exposed only to IL-1beta (P <=0.04). Dinoprostone 15-19 interleukin 6 Homo sapiens 94-98 14645533-3 2003 By transfection with various COX-2 promoter reporter constructs, we found that the bp -327-to-+59 promoter region was essential for COX-2 gene transcription by bradykinin and IL-1beta and that the cyclic AMP response element (CRE) was critical in bradykinin-induced transcription, whereas nuclear factor IL-6 and CRE and, to a lesser extent, nuclear factor-kappaB (NF-kappaB) were involved in IL-1beta-induced transcription. Cyclic AMP 197-207 interleukin 6 Homo sapiens 304-308 14694226-12 2003 Coronary calcium scores were significantly correlated with age and interleukin-6 and significantly and negatively correlated to insulin sensitivity index. Calcium 9-16 interleukin 6 Homo sapiens 67-80 12952969-6 2003 This effect of IL-6 was accompanied by a marked reduction in IRS-1, but not IRS-2, protein expression, and insulin-stimulated tyrosine phosphorylation, whereas no inhibitory effect was seen on the insulin receptor tyrosine phosphorylation. Tyrosine 126-134 interleukin 6 Homo sapiens 15-19 12952969-7 2003 Consistent with the reduced GLUT-4 mRNA, insulin-stimulated glucose transport was also significantly reduced by IL-6. Glucose 60-67 interleukin 6 Homo sapiens 112-116 12855565-5 2003 Moreover, AS-Hsp27 overcomes interleukin-6 (IL-6)-mediated protection against Dex-induced apoptosis. Dexamethasone 78-81 interleukin 6 Homo sapiens 29-42 14605496-9 2003 Mesothelial cells chronically exposed to glucose became activated after subsequent exposure to the dialysis fluid, as reflected by the increased release of interleukin (IL)-6, in contrast to control mesothelial cells, in which IL-6 synthesis was suppressed. Glucose 41-48 interleukin 6 Homo sapiens 156-174 14605496-9 2003 Mesothelial cells chronically exposed to glucose became activated after subsequent exposure to the dialysis fluid, as reflected by the increased release of interleukin (IL)-6, in contrast to control mesothelial cells, in which IL-6 synthesis was suppressed. Glucose 41-48 interleukin 6 Homo sapiens 227-231 14530076-12 2003 At the cellular level, there was an even higher correlation between the quantity of metal particles and the production of IL-1beta and IL-6 (r=-0.99), while TNF-alpha did not demonstrate any correlation, remaining at very low levels. Metals 84-89 interleukin 6 Homo sapiens 135-139 14627919-0 2003 C-jun N-terminal kinase (JNK) inhibitor, SP600125, blocks interleukin (IL)-6-induced vascular endothelial growth factor (VEGF) production: cyclosporine A partially mimics this inhibitory effect. Cyclosporine 139-153 interleukin 6 Homo sapiens 58-76 14627919-8 2003 In fact, CsA suppressed IL-6-induced phosphorylation of JNK. Cyclosporine 9-12 interleukin 6 Homo sapiens 24-28 14581275-10 2003 Response to paclitaxel was associated with a fall in plasma IL-6 levels (P = 0.04) but no change in other cytokines. Paclitaxel 12-22 interleukin 6 Homo sapiens 60-64 14581275-13 2003 Response to paclitaxel therapy correlates with a fall in plasma IL-6 levels and recent data indicate this may be a surrogate marker of KS-associated herpesvirus viral load. Paclitaxel 12-22 interleukin 6 Homo sapiens 64-68 12855565-5 2003 Moreover, AS-Hsp27 overcomes interleukin-6 (IL-6)-mediated protection against Dex-induced apoptosis. Dexamethasone 78-81 interleukin 6 Homo sapiens 44-48 14585094-8 2003 Dexamethasone strongly inhibited basal IL-6 secretion in all IL-6-producing adenoma cell cultures, whereas the IL-6 inhibitory or stimulatory action of other factors (octreotide, transforming growth factor-beta1, insulin-like growth factor-I, pituitary adenylate cyclase-activating peptide and oestradiol) were heterogeneous in the different adenomas. Dexamethasone 0-13 interleukin 6 Homo sapiens 39-43 14740444-5 2003 Thus, available steroid pre-hormones are rapidly converted to proinflammatory estrogens in the synovial tissue in the presence of inflammatory cytokines (i.e. TNF alpha, IL-1, IL-6). Steroids 16-23 interleukin 6 Homo sapiens 176-180 14605526-14 2003 CONCLUSIONS: Administration of N-acetylcysteine results in decreased nuclear factor-kappa B activation in patients with sepsis, associated with decreases in interleukin-8 but not interleukin-6 or soluble intercellular adhesion molecule-1. Acetylcysteine 31-47 interleukin 6 Homo sapiens 179-192 14585094-8 2003 Dexamethasone strongly inhibited basal IL-6 secretion in all IL-6-producing adenoma cell cultures, whereas the IL-6 inhibitory or stimulatory action of other factors (octreotide, transforming growth factor-beta1, insulin-like growth factor-I, pituitary adenylate cyclase-activating peptide and oestradiol) were heterogeneous in the different adenomas. Dexamethasone 0-13 interleukin 6 Homo sapiens 61-65 14585094-8 2003 Dexamethasone strongly inhibited basal IL-6 secretion in all IL-6-producing adenoma cell cultures, whereas the IL-6 inhibitory or stimulatory action of other factors (octreotide, transforming growth factor-beta1, insulin-like growth factor-I, pituitary adenylate cyclase-activating peptide and oestradiol) were heterogeneous in the different adenomas. Dexamethasone 0-13 interleukin 6 Homo sapiens 61-65 14646384-0 2003 Azelastine inhibits secretion of IL-6, TNF-alpha and IL-8 as well as NF-kappaB activation and intracellular calcium ion levels in normal human mast cells. azelastine 0-10 interleukin 6 Homo sapiens 33-37 14500551-10 2003 In conclusion, we show that: 1) TGF-beta receptor Type II is predominantly located on basolateral membrane and receptor stimulation activates Smad pathway; 2) TGF-beta1 down-regulates IL-6-induced tyrosine phoshorylation of STAT1 and STAT3 and ICAM-1 expression; and 3) Smad2 is required for the down-regulation of IL-6 signaling by TGF-beta. Tyrosine 197-205 interleukin 6 Homo sapiens 184-188 14500551-10 2003 In conclusion, we show that: 1) TGF-beta receptor Type II is predominantly located on basolateral membrane and receptor stimulation activates Smad pathway; 2) TGF-beta1 down-regulates IL-6-induced tyrosine phoshorylation of STAT1 and STAT3 and ICAM-1 expression; and 3) Smad2 is required for the down-regulation of IL-6 signaling by TGF-beta. Tyrosine 197-205 interleukin 6 Homo sapiens 315-319 14500551-7 2003 We show that pretreatment of cells with TGF-beta1 is associated with a down-regulation of IL-6 induced tyrosine phosphorylation of STAT1 and STAT3 and suppression of ICAM-1 expression. Tyrosine 103-111 interleukin 6 Homo sapiens 90-94 14533000-0 2003 N-3 fatty acid-rich diet prevents early response of interleukin-6 elevation in trinitrobenzene sulfonic acid-induced enteritis. Trinitrobenzenesulfonic Acid 79-108 interleukin 6 Homo sapiens 52-65 14646384-3 2003 METHODS: We investigated the effect of azelastine on the secretion of IL-6, TNF-alpha and IL-8 from hCBMC, as well as its possible mechanism of action. azelastine 39-49 interleukin 6 Homo sapiens 70-74 14646384-9 2003 CONCLUSION: Azelastine inhibited hCBMC secretion of IL-6, TNF-alpha and IL-8, possibly by inhibiting intracellular Ca2+ ions and NF-kappaB activation. azelastine 12-22 interleukin 6 Homo sapiens 52-56 12900415-9 2003 In the absence of a functional glucocorticoid receptor response element, dexamethasone potentiated IL-6-induced gammaFBG promoter activity 2-fold, requiring promoter-proximal Site I and Site II; the promoter-distal Site III had no effect on dexamethasone potentiation of IL-6-induced promoter activity. Dexamethasone 73-86 interleukin 6 Homo sapiens 99-103 14586407-6 2003 Inhibition of the ERK activation by PD98059 and transfection of a dominant-negative ERK2 completely blocked the protection of IL-6 against apoptosis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 36-43 interleukin 6 Homo sapiens 126-130 14563377-8 2003 Acute hydrocortisone administration suppressed TNF-alpha and IL-6 levels independently of baseline HPA system activity. Hydrocortisone 6-20 interleukin 6 Homo sapiens 61-65 14574636-9 2003 Subjects with an alcohol intake of > 40 grams per day showed a statistically significant increase in levels of interleukin-6 (0.50 pg/ml) compared to non-drinkers. Alcohols 17-24 interleukin 6 Homo sapiens 114-127 12900415-9 2003 In the absence of a functional glucocorticoid receptor response element, dexamethasone potentiated IL-6-induced gammaFBG promoter activity 2-fold, requiring promoter-proximal Site I and Site II; the promoter-distal Site III had no effect on dexamethasone potentiation of IL-6-induced promoter activity. Dexamethasone 73-86 interleukin 6 Homo sapiens 271-275 12900415-9 2003 In the absence of a functional glucocorticoid receptor response element, dexamethasone potentiated IL-6-induced gammaFBG promoter activity 2-fold, requiring promoter-proximal Site I and Site II; the promoter-distal Site III had no effect on dexamethasone potentiation of IL-6-induced promoter activity. Dexamethasone 241-254 interleukin 6 Homo sapiens 99-103 12730073-0 2003 Interleukin-11 and interleukin-6 protect cultured human endothelial cells from H2O2-induced cell death. Hydrogen Peroxide 79-83 interleukin 6 Homo sapiens 19-32 12730073-2 2003 Previous studies have determined that both interleukin (IL)-6 and IL-11 are protective in oxygen toxicity. Oxygen 90-96 interleukin 6 Homo sapiens 43-61 12730073-7 2003 We found that preincubation of HUVEC cultures with either IL-6 or IL-11 diminished H2O2 (1.0 mM)-induced cell death. Hydrogen Peroxide 83-87 interleukin 6 Homo sapiens 58-62 13679004-1 2003 There is recent evidence that nitric oxide blocks IL-6 signaling in hepatocytes by inhibiting activation of Stat3. Nitric Oxide 30-42 interleukin 6 Homo sapiens 50-54 14612208-7 2003 Furthermore, IL-6 showed a strong negative relationship with apo A-1 and HDL-cholesterol in females only (P<0.001). Cholesterol 77-88 interleukin 6 Homo sapiens 13-17 14557432-13 2003 The fall in CRP and IL-6 was more pronounced with the high- than low-dose vitamin D (P < 0.05). Vitamin D 74-83 interleukin 6 Homo sapiens 20-24 14653390-4 2003 RESULTS: The results showed that IL-6 elicited an inhibitory effect on collagen and GAG levels in CLP fibroblasts by lowering hyaluronan and dermatan sulfate secretion. Dermatan Sulfate 141-157 interleukin 6 Homo sapiens 33-37 14519071-1 2003 Interleukin (IL)-6 is a multifunctional immune-modulating cytokine that has been suggested to have important functions in glucose and lipid metabolism. Glucose 122-129 interleukin 6 Homo sapiens 0-18 14530793-5 2003 We have shown that, in vitro, histamine induces a concentration-dependent release of IL-6 and beta-glucuronidase from macrophages isolated from the human lung parenchyma. Histamine 30-39 interleukin 6 Homo sapiens 85-89 14557477-8 2003 IL-1alpha and dibutyryl cAMP stimulated and dexamethasone inhibited IL-6 secretion; however, bacterial lipopolysaccharide, forskolin, and cholera toxin had no effect. Dexamethasone 44-57 interleukin 6 Homo sapiens 68-72 14500688-0 2003 Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells. Curcumin 0-8 interleukin 6 Homo sapiens 55-59 14500688-0 2003 Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells. Curcumin 10-27 interleukin 6 Homo sapiens 55-59 14500688-3 2003 In the present report, we demonstrate that curcumin (diferuloylmethane), a pharmacologically safe agent in humans, inhibited IL-6-induced STAT3 phosphorylation and consequent STAT3 nuclear translocation. Curcumin 43-51 interleukin 6 Homo sapiens 125-129 14500688-3 2003 In the present report, we demonstrate that curcumin (diferuloylmethane), a pharmacologically safe agent in humans, inhibited IL-6-induced STAT3 phosphorylation and consequent STAT3 nuclear translocation. Curcumin 53-70 interleukin 6 Homo sapiens 125-129 14519784-3 2003 Subsequently, endothelial cells were activated by treatment with linoleic acid (90 micro mol/L) for 6 h. Zinc chelation by TPEN increased the DNA binding activity of nuclear factor (NF)-kappaB and activator protein (AP)-1, decreased PPARgamma expression and activation as well as up-regulated interleukin (IL)-6 expression and production. Linoleic Acid 65-78 interleukin 6 Homo sapiens 293-311 14523327-12 2003 CONCLUSIONS: The norepinephrine-induced increase in plasma and CSF IL-6 suggests that concomitant norepinephrine administration needs to be considered when interpreting systemic and local changes in IL-6 levels in TBI patients. Norepinephrine 17-31 interleukin 6 Homo sapiens 67-71 14523327-12 2003 CONCLUSIONS: The norepinephrine-induced increase in plasma and CSF IL-6 suggests that concomitant norepinephrine administration needs to be considered when interpreting systemic and local changes in IL-6 levels in TBI patients. Norepinephrine 17-31 interleukin 6 Homo sapiens 199-203 14523327-12 2003 CONCLUSIONS: The norepinephrine-induced increase in plasma and CSF IL-6 suggests that concomitant norepinephrine administration needs to be considered when interpreting systemic and local changes in IL-6 levels in TBI patients. Norepinephrine 98-112 interleukin 6 Homo sapiens 67-71 12967650-4 2003 Treatment of UVB-irradiated NCTC 2544 cells with drugs known to enhance cAMP concentration [dibutyryl cAMP, PGE(2) and cholera toxin] results in a significant decrease of TNF-alpha mRNA expression whereas IL-6 and IL-10 mRNAs were enhanced. Cyclic AMP 72-76 interleukin 6 Homo sapiens 205-209 12960491-7 2003 Prostaglandin E2 levels can distinguish two types of patients with osteoarthritis: osteoblasts from one group produce low levels of prostaglandin E2 and interleukin-6, and the other shows an increase in production. Dinoprostone 0-16 interleukin 6 Homo sapiens 153-166 15038780-5 2003 Dexamethasone significantly reduced IL-1 beta, IL-6, COX-2, and MMP-1 expression at high cell density. Dexamethasone 0-13 interleukin 6 Homo sapiens 47-51 12940901-2 2003 Many water-soluble mediators with pro- and anti-inflammatory action such as TNF, IL-6, IL-8, and IL-10 play a strategic role in septic syndrome. Water 5-10 interleukin 6 Homo sapiens 81-85 14502144-9 2003 Interleukin-6 and interleukin-8 concentrations correlated with the length of inotropic support, as well as with the length of mechanical ventilation (r >.70, P </=.0006), and were inversely related to the ratio of arterial oxygen tension to fraction of inspired oxygen. Oxygen 229-235 interleukin 6 Homo sapiens 0-13 14502144-9 2003 Interleukin-6 and interleukin-8 concentrations correlated with the length of inotropic support, as well as with the length of mechanical ventilation (r >.70, P </=.0006), and were inversely related to the ratio of arterial oxygen tension to fraction of inspired oxygen. Oxygen 268-274 interleukin 6 Homo sapiens 0-13 12967650-4 2003 Treatment of UVB-irradiated NCTC 2544 cells with drugs known to enhance cAMP concentration [dibutyryl cAMP, PGE(2) and cholera toxin] results in a significant decrease of TNF-alpha mRNA expression whereas IL-6 and IL-10 mRNAs were enhanced. Cyclic AMP 102-106 interleukin 6 Homo sapiens 205-209 12967650-6 2003 Except for IL-10, the pharmacological effect of cAMP-elevating agents or PKA inhibitors on radiation-induced TNF-alpha and IL-6 mRNA expression was associated with a concomitant regulation of cytokine release. Cyclic AMP 48-52 interleukin 6 Homo sapiens 123-127 12921980-0 2003 Soluble intercellular adhesion molecule-1 and interleukin-6 levels reflect endothelial dysfunction in patients with primary hypercholesterolaemia treated with atorvastatin. Atorvastatin 159-171 interleukin 6 Homo sapiens 46-59 12915102-8 2003 It was found that the increase in IL-6 protein and mRNA by the PA coal was completely eliminated by the pretreatment of both cell types with PD98059, a specific MEK1 inhibitor, and SB202190, a p38 kinase inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 141-148 interleukin 6 Homo sapiens 34-38 26983566-5 2003 GC sensitivity was assessed in vitro by dexamethasone inhibition of lipopolysaccharide-stimulated production of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNC-alpha). Dexamethasone 40-53 interleukin 6 Homo sapiens 112-125 26983566-5 2003 GC sensitivity was assessed in vitro by dexamethasone inhibition of lipopolysaccharide-stimulated production of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNC-alpha). Dexamethasone 40-53 interleukin 6 Homo sapiens 127-131 12873450-8 2003 Baicalin did not suppress IL-1beta-induced IL-6 and IL-8 production, but dexamethasone, baicalein, and wogonin, significantly suppressed IL-6 and IL-8 production. Dexamethasone 73-86 interleukin 6 Homo sapiens 137-141 12873450-9 2003 Elevation of IL-6 and IL-8 mRNA was not suppressed by baicalin but was significantly suppressed by dexamethasone, baicalein, and wogonin. Dexamethasone 99-112 interleukin 6 Homo sapiens 13-17 12860861-8 2003 Interestingly, urinary 15-F2t-isoprostane concentrations significantly correlated with plasma BNP concentrations and serum IL-6 concentrations, but not with serum thrombomodulin concentrations. 8-epi-prostaglandin F2alpha 23-41 interleukin 6 Homo sapiens 123-127 19180800-6 2003 When NaCl (1 mg/mL) was added, the secretion of TNF-alpha and IL-6 was also inhibited but the effect was markedly lower than purple bamboo salt. Sodium Chloride 5-9 interleukin 6 Homo sapiens 62-66 12953163-5 2003 The inhibitory effect on IL-6 mRNA was prevented by the intermediates of the cholesterol synthesis pathway, mevalonate and geranyl-geranyl-phyrophosphate (GGPP) but not by farnesyl-pyrophosphate. Cholesterol 77-88 interleukin 6 Homo sapiens 25-29 12953165-0 2003 Reduction in serum levels of adhesion molecules, interleukin-6 and C-reactive protein following short-term low-dose atorvastatin treatment in patients with non-familial hypercholesterolemia. Atorvastatin 116-128 interleukin 6 Homo sapiens 49-62 19180800-4 2003 Purple bamboo salt (1 mg/mL) inhibited phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 secretion, by 67.04% +/- 0.08%, 68.01% +/- 1.85%, and 69.48% +/- 0.54%, respectively. Tetradecanoylphorbol Acetate 39-70 interleukin 6 Homo sapiens 180-184 12746441-3 2003 In this study, by systematic deletion and site-directed mutagenesis we identified Arg-214/215 in the alpha-helix 2 region of the coiled-coil domain of Stat3 as a novel sequence element essential for its nuclear translocation, stimulated by epidermal growth factor as well as by interleukin-6. Arginine 82-85 interleukin 6 Homo sapiens 278-291 19180800-4 2003 Purple bamboo salt (1 mg/mL) inhibited phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 secretion, by 67.04% +/- 0.08%, 68.01% +/- 1.85%, and 69.48% +/- 0.54%, respectively. Tetradecanoylphorbol Acetate 72-75 interleukin 6 Homo sapiens 180-184 12953165-2 2003 The aim of this study was to investigate the effects of three months of treatment with low dose atorvastatin on serum levels of adhesion molecules, interleukin-6 (IL-6) and highly sensitive C-reactive protein (hs-CRP) in patients with non-familial hypercholesterolemia. Atorvastatin 96-108 interleukin 6 Homo sapiens 148-161 12953165-2 2003 The aim of this study was to investigate the effects of three months of treatment with low dose atorvastatin on serum levels of adhesion molecules, interleukin-6 (IL-6) and highly sensitive C-reactive protein (hs-CRP) in patients with non-familial hypercholesterolemia. Atorvastatin 96-108 interleukin 6 Homo sapiens 163-167 12746441-7 2003 The mutant of Arg-214/215 or Arg-414/417 was shown to be tyrosyl-phosphorylated normally but failed to enter the nucleus in response to epidermal growth factor or interleukin-6. Arginine 14-17 interleukin 6 Homo sapiens 163-176 12931816-8 2003 Palacos particles also caused significant release of IL-6, another pro-osteolytic cytokine, while CMW did not. palacos 0-7 interleukin 6 Homo sapiens 53-57 14651593-7 2003 There was a significant inverse correlation between DHEA-S and IL-6, TNF-alpha, and CRP concentrations. Dehydroepiandrosterone Sulfate 52-58 interleukin 6 Homo sapiens 63-67 12794182-0 2003 IL-6 gene expression in human adipose tissue in response to exercise--effect of carbohydrate ingestion. Carbohydrates 80-92 interleukin 6 Homo sapiens 0-4 12794182-3 2003 In contrast, the increase in plasma IL-6 is blunted if carbohydrate is administered, indicating a substrate-regulated induction of IL-6 in human skeletal muscle. Carbohydrates 55-67 interleukin 6 Homo sapiens 36-40 12794182-3 2003 In contrast, the increase in plasma IL-6 is blunted if carbohydrate is administered, indicating a substrate-regulated induction of IL-6 in human skeletal muscle. Carbohydrates 55-67 interleukin 6 Homo sapiens 131-135 12794182-12 2003 In conclusion, exercise results in an increase in IL-6 gene expression in adipose tissue in response to exercise, an effect that is significantly blunted by ingestion of carbohydrate. Carbohydrates 170-182 interleukin 6 Homo sapiens 50-54 12891120-1 2003 BACKGROUND: Prostaglandin (PG) E(2) (PGE(2)) appears to have a role in stimulating production of interleukin-6 (IL-6) and apoptosis of smooth muscle cells in diseased aortic tissue. Dinoprostone 12-35 interleukin 6 Homo sapiens 97-110 12891120-1 2003 BACKGROUND: Prostaglandin (PG) E(2) (PGE(2)) appears to have a role in stimulating production of interleukin-6 (IL-6) and apoptosis of smooth muscle cells in diseased aortic tissue. Dinoprostone 12-35 interleukin 6 Homo sapiens 112-116 12891120-1 2003 BACKGROUND: Prostaglandin (PG) E(2) (PGE(2)) appears to have a role in stimulating production of interleukin-6 (IL-6) and apoptosis of smooth muscle cells in diseased aortic tissue. Dinoprostone 37-43 interleukin 6 Homo sapiens 97-110 12891120-1 2003 BACKGROUND: Prostaglandin (PG) E(2) (PGE(2)) appears to have a role in stimulating production of interleukin-6 (IL-6) and apoptosis of smooth muscle cells in diseased aortic tissue. Dinoprostone 37-43 interleukin 6 Homo sapiens 112-116 12918129-3 2003 We assessed the role of glucose in the regulation of circulating levels of insulin, glucagon, cortisol, IL-6 and TNF-alpha in human sepsis with normal or impaired glucose tolerance. Glucose 24-31 interleukin 6 Homo sapiens 104-108 12843357-10 2003 The common haplotype A-G-8/12-C was associated with low IL-6 levels after stroke and a reduced induction of IL-6 transcription on stimulation with an adenosine analog in vitro. Adenosine 150-159 interleukin 6 Homo sapiens 56-60 12843357-10 2003 The common haplotype A-G-8/12-C was associated with low IL-6 levels after stroke and a reduced induction of IL-6 transcription on stimulation with an adenosine analog in vitro. Adenosine 150-159 interleukin 6 Homo sapiens 108-112 12818436-4 2003 Spontaneous and phytohemaglutynine stimulated "in vitro" secretion of IL-2, IL-4, IL-6, IL-10, IL-12, IFN-gamma and TGF-beta by decidual lymphocytes was studied by ELISA. phytohemaglutynine 16-34 interleukin 6 Homo sapiens 82-86 12847270-7 2003 15dPGJ(2) also attenuated IL-6-induced tyrosine phosphorylation of STAT1 and STAT3 in Hep3B hepatoma cells. Tyrosine 39-47 interleukin 6 Homo sapiens 26-30 12853969-7 2003 TGF-beta1 activated c-Jun phosphorylation, and IL-6 induction by TGF-beta1 was severely impeded by DN-c-Jun and DN-JNK or AP-1 inhibitor curcumin, showing that the JNK-c-Jun-AP-1 signaling plays a pivotal role in TGF-beta1 stimulation of IL-6. Curcumin 137-145 interleukin 6 Homo sapiens 47-51 12775578-6 2003 Interleukin-6 appeared as a risk marker of MI-coronary death, and it improved the definition of CHD risk beyond LDL cholesterol. Cholesterol 116-127 interleukin 6 Homo sapiens 0-13 12810609-8 2003 Statistically significant correlations between IL-6 and both 8-iso-PGF2alpha (r=0.63, P<0.001) and 11-dehydro-TXB2 (r=0.51, P<0.01) were observed. 8-epi-prostaglandin F2alpha 61-76 interleukin 6 Homo sapiens 47-51 12791215-2 2003 Histamine, released from the conjunctival mast cells, might stimulate the synthesis of proinflammatory molecules such as IL-6 and IL-8 by the epithelial cells through the receptors that couple to inositol phosphate generation and, therefore, amplify the allergic response. Histamine 0-9 interleukin 6 Homo sapiens 121-125 12832326-8 2003 N-acetylcysteine (NAC) prevented the IL-6 secretion in acetoacetate-treated U937 monocytes. Acetylcysteine 0-16 interleukin 6 Homo sapiens 37-41 12832326-8 2003 N-acetylcysteine (NAC) prevented the IL-6 secretion in acetoacetate-treated U937 monocytes. Acetylcysteine 18-21 interleukin 6 Homo sapiens 37-41 12832326-9 2003 CONCLUSIONS: This study demonstrates that hyperketonemia increases IL-6 levels in the blood of type 1 diabetic patients and that NAC can inhibit IL-6 secretion by U937 monocytic cells cultured in a ketotic medium. Acetylcysteine 129-132 interleukin 6 Homo sapiens 145-149 12851884-10 2003 Finally, in vitro IL-6 treatment of donor livers also markedly reduces mortality associated with fatty liver transplants from alcohol-fed rats. Alcohols 126-133 interleukin 6 Homo sapiens 18-22 12882457-5 2003 IL-6 and IL-8 production was lower in COPD patients taking inhaled steroids. Steroids 67-75 interleukin 6 Homo sapiens 0-4 12746834-0 2003 Possible mechanism of dexamethasone therapy for prostate cancer: suppression of circulating level of interleukin-6. Dexamethasone 22-35 interleukin 6 Homo sapiens 101-114 12732938-0 2003 Interleukin-6 changes tight junction permeability and intracellular phospholipid content in a human enterocyte cell culture model. Phospholipids 68-80 interleukin 6 Homo sapiens 0-13 12746834-5 2003 Of 8 patients who responded to dexamethasone therapy, 5 had 80% or more decrease in serum interleukin-6 (IL-6). Dexamethasone 31-44 interleukin 6 Homo sapiens 90-103 12732938-3 2003 To determine the physiological effects of the IL-6 mediated increase in sPLA(2) on decreased epithelial layer integrity, we investigated alterations of intracellular/secretory phospholipid (PL) composition in a cell culture model. Phospholipids 73-75 interleukin 6 Homo sapiens 46-50 12732938-8 2003 Total intracellular PL contents were also unchanged; however, IL-6 led to significant changes in PL composition including an increase in phosphatidylethanolamine (PE) and sphingomyelin (SM) and a decrease in phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) ( p<0.05). Phospholipids 97-99 interleukin 6 Homo sapiens 62-66 12968847-7 2003 RESULTS: Viability and release of IL-6 from HPMCs pretreated with H-PDF (pH 7.3) for 1 to 4 hours were significantly reduced compared to cells exposed to corresponding F-PDF. h-pdf 66-71 interleukin 6 Homo sapiens 34-38 12746834-5 2003 Of 8 patients who responded to dexamethasone therapy, 5 had 80% or more decrease in serum interleukin-6 (IL-6). Dexamethasone 31-44 interleukin 6 Homo sapiens 105-109 12968847-8 2003 Incubation in medium mixed (1:1) with H-PDF considerably impaired growth of HPMCs, and over a period of 10 days gradually decreased both the viability of HPMCs and their ability to generate IL-6. h-pdf 38-43 interleukin 6 Homo sapiens 190-194 12746834-8 2003 CONCLUSIONS: Significant suppression of serum IL-6, probably through inhibition of androgen-independent activation of androgen receptor, may be one of the mechanisms for the effect of dexamethasone therapy in prostate cancer patients with progressive disease. Dexamethasone 184-197 interleukin 6 Homo sapiens 46-50 12785003-0 2003 Adenosine treatment attenuates cytokine interleukin-6 responses to endotoxin challenge in healthy volunteers. Adenosine 0-9 interleukin 6 Homo sapiens 40-53 12829918-5 2003 Coinciding with a significantly higher steroid dosage in CR patients, IL-6 receptor and TNF-R1 expression on monocytes were down-regulated (P< or =0.02) and AC was suppressed in CR compared with ST (non-MMF) patients (P<0.01, SED; P<0.05, SEE). Steroids 39-46 interleukin 6 Homo sapiens 70-74 12756159-8 2003 Patients who received combined steroids had lower serum IL-6 and increased IL-10 at end-bypass (P<0.05), although differences were negligible by 24 hours. Steroids 31-39 interleukin 6 Homo sapiens 56-60 12796753-9 2003 Elevated sP-selectin levels (>152 ng/mL; odds ratio, 3.2; 95% CI, 0.9-11.6; P =.06) trended to increased death/MI rates, with weaker trends for elevated levels of hsCRP (>7.1 mg/L), IL6 (>10.7 pg/mL), and ST depression. TFF2 protein, human 9-11 interleukin 6 Homo sapiens 188-191 12796255-7 2003 Secretions of PGE2, IL-1alpha, and IL-6 at x10 dilutions of latanoprost or timolol were 3 to 77 times higher than in controls, whereas they were 190 to 305 times higher at a x180 dilution of benzalkonium chloride. Timolol 75-82 interleukin 6 Homo sapiens 35-39 12773123-3 2003 We investigated and compared the effects of 17-beta oestradiol (E(2)) and RAL on the regulation of IL-6, IL-1, RANKL and OPG in vitro in primary human osteoblastic (HOB) cells and in an immortalised clonal human bone marrow stromal cell line (HCC1) with osteoblastic characteristics. Estradiol 44-62 interleukin 6 Homo sapiens 99-103 12702735-0 2003 Glucose ingestion attenuates interleukin-6 release from contracting skeletal muscle in humans. Glucose 0-7 interleukin 6 Homo sapiens 29-42 12702735-1 2003 To examine whether glucose ingestion during exercise affects the release of interleukin-6 (IL-6) from the contracting limb, seven men performed 120 min of semi-recumbent cycling on two occasions while ingesting either 250 ml of a 6.4 % carbohydrate (GLU trial) or sweet placebo (CON trial) beverage at the onset of, and at 15 min intervals throughout, exercise. Glucose 19-26 interleukin 6 Homo sapiens 91-95 12702735-5 2003 The arterial IL-6 concentration was lower (P < 0.05) after 120 min of exercise in GLU, but neither intramuscular glycogen nor IL-6 mRNA were different when comparing GLU with CON. Glutamic Acid 85-88 interleukin 6 Homo sapiens 13-17 12702735-6 2003 However, net leg IL-6 release was attenuated (P < 0.05) in GLU compared with CON. Glutamic Acid 62-65 interleukin 6 Homo sapiens 17-21 12702735-8 2003 These results demonstrate that glucose ingestion during exercise attenuates leg IL-6 release but does not decrease intramuscular expression of IL-6 mRNA. Glucose 31-38 interleukin 6 Homo sapiens 80-84 12883121-6 2003 Inhibition of IL-6 release was determined by coincubation with increasing concentrations of dexamethasone. Dexamethasone 92-105 interleukin 6 Homo sapiens 14-18 12883121-7 2003 Monocyte glucocorticoid sensitivity was defined as the dexamethasone concentration inhibiting IL-6 release by 50%. Dexamethasone 55-68 interleukin 6 Homo sapiens 94-98 12883121-10 2003 However, in highly exhausted participants, dexamethasone was less able to inhibit IL-6 release (p=.010), and the glucocorticoid sensitivity was lower (p=.003) than in nonexhausted subjects. Dexamethasone 43-56 interleukin 6 Homo sapiens 82-86 12859859-6 2003 Additionally, circulating IL-6 was also significantly correlated with plasma norepinephrine (r = 0.86, p < 0.001) and right atrial pressure (r = 0.57, p < 0.01). Norepinephrine 77-91 interleukin 6 Homo sapiens 26-30 12785003-7 2003 The plasma IL-6 response to endotoxin was attenuated by adenosine, as IL-6 increased from 0.9 (0.8-1.6) to 1345 (743-1906) pg/mL (median; 25-75th percentiles) with adenosine infusion, and from 0.8 (0.5-1) to 1,959 (1,344-2,505) pg/mL with placebo (P = 0.0065). Adenosine 56-65 interleukin 6 Homo sapiens 70-74 12785003-7 2003 The plasma IL-6 response to endotoxin was attenuated by adenosine, as IL-6 increased from 0.9 (0.8-1.6) to 1345 (743-1906) pg/mL (median; 25-75th percentiles) with adenosine infusion, and from 0.8 (0.5-1) to 1,959 (1,344-2,505) pg/mL with placebo (P = 0.0065). Adenosine 164-173 interleukin 6 Homo sapiens 11-15 12785003-9 2003 In conclusion, systemic adenosine infusion counteracts the release of IL-6 in healthy volunteers, indicating an anti-inflammatory effect of adenosine which should be further explored. Adenosine 24-33 interleukin 6 Homo sapiens 70-74 12785003-9 2003 In conclusion, systemic adenosine infusion counteracts the release of IL-6 in healthy volunteers, indicating an anti-inflammatory effect of adenosine which should be further explored. Adenosine 140-149 interleukin 6 Homo sapiens 70-74 12785003-7 2003 The plasma IL-6 response to endotoxin was attenuated by adenosine, as IL-6 increased from 0.9 (0.8-1.6) to 1345 (743-1906) pg/mL (median; 25-75th percentiles) with adenosine infusion, and from 0.8 (0.5-1) to 1,959 (1,344-2,505) pg/mL with placebo (P = 0.0065). Adenosine 56-65 interleukin 6 Homo sapiens 11-15 14513800-1 2003 AIM: To study the effects of lipopolysaccharide (LPS), the supernatant of U937 cells stimulated with LPS and dexamethasone on interleukin-6 (IL-6) expression in the synoviocyte from patients with rheumatoid arthritis (RA). Dexamethasone 109-122 interleukin 6 Homo sapiens 126-139 14513800-1 2003 AIM: To study the effects of lipopolysaccharide (LPS), the supernatant of U937 cells stimulated with LPS and dexamethasone on interleukin-6 (IL-6) expression in the synoviocyte from patients with rheumatoid arthritis (RA). Dexamethasone 109-122 interleukin 6 Homo sapiens 141-145 14513800-6 2003 Dexamethasone markedly inhibited the protein secretion and mRNA expression of IL-6 in FLS cultured with the supernatant from U937 cell stimulated with LPS. Dexamethasone 0-13 interleukin 6 Homo sapiens 78-82 14513800-9 2003 Dexamethasone can inhibit this increase of the IL-6 expression. Dexamethasone 0-13 interleukin 6 Homo sapiens 47-51 12719374-0 2003 Association of a functional 17beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females. Estradiol 28-44 interleukin 6 Homo sapiens 55-58 12719374-7 2003 The impact of 17beta-estradiol (E(2)) on the IL6-174G/C variants was investigated by reporter studies. Estradiol 14-30 interleukin 6 Homo sapiens 45-48 12721390-7 2003 Conversely, the TRPV1 antagonist capsazepine, as well as calcium chelation by EGTA ablated cytokine (IL-6) production after capsaicin exposure. Calcium 57-64 interleukin 6 Homo sapiens 101-105 12738719-21 2003 Serum levels of proangiogenic factors IL-6, IL-8, VEGF, and bFGF may correlate with copper depletion but not with disease stability in this small cohort. Copper 84-90 interleukin 6 Homo sapiens 38-42 12748876-4 2003 In addition, granulosa cells obtained from the follicular fluid were cultured and treated with forskolin and 12- o-tetradecanoylphorbol 13-acetate for 24-48 h. The concentration of IL-6 was significantly higher in the follicular fluid than in the serum (P<0.01). Tetradecanoylphorbol Acetate 109-146 interleukin 6 Homo sapiens 181-185 12748876-9 2003 It is possible that IL-6 in particular may be regulated by cAMP. Cyclic AMP 59-63 interleukin 6 Homo sapiens 20-24 12792232-5 2003 Cholesterol and lipoprotein concentrations decreased by at least 40% in patients with burns >20% total body surface area and inversely correlated with IL-6. Cholesterol 0-11 interleukin 6 Homo sapiens 154-158 12713584-7 2003 Functional significance of these findings was proven in adhesion assays using fibronectin, laminin, and vitronectin, with interleukin-6 causing significant enhancement of adhesion in all cases, tumor necrosis factor alpha and dexamethasone inducing significant reduction of adhesion to fibronectin and laminin, and interferon-gamma significantly inhibiting adhesion to fibronectin only. Dexamethasone 226-239 interleukin 6 Homo sapiens 122-135 12595539-6 2003 IL-6 increased phosphorylation of STAT3 (at Tyr(705)) and ERK1/2 (at Tyr(204)) within 5 min that peaked at 15-30 min and returned to basal levels at 2 h. Phosphorylation of STAT3 was blocked by genistein, a protein tyrosine kinase inhibitor, and AG490, a JAK2 inhibitor, but not PD98059, an ERK1/2 kinase inhibitor. Tyrosine 44-47 interleukin 6 Homo sapiens 0-4 12595539-6 2003 IL-6 increased phosphorylation of STAT3 (at Tyr(705)) and ERK1/2 (at Tyr(204)) within 5 min that peaked at 15-30 min and returned to basal levels at 2 h. Phosphorylation of STAT3 was blocked by genistein, a protein tyrosine kinase inhibitor, and AG490, a JAK2 inhibitor, but not PD98059, an ERK1/2 kinase inhibitor. Tyrosine 69-72 interleukin 6 Homo sapiens 0-4 12595539-6 2003 IL-6 increased phosphorylation of STAT3 (at Tyr(705)) and ERK1/2 (at Tyr(204)) within 5 min that peaked at 15-30 min and returned to basal levels at 2 h. Phosphorylation of STAT3 was blocked by genistein, a protein tyrosine kinase inhibitor, and AG490, a JAK2 inhibitor, but not PD98059, an ERK1/2 kinase inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 279-286 interleukin 6 Homo sapiens 0-4 12505790-3 2003 Treatment with the p38 inhibitor SB-203580, the MEK1 and MEK2 inhibitor U-0126, or the translational inhibitor cycloheximide inhibited the induction of C/EBP beta and IL-6 by IFN-gamma, whereas the MEK1 inhibitor PD-98059 or the tyrosine kinase inhibitor genistein had no effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 213-221 interleukin 6 Homo sapiens 167-171 12716789-5 2003 RESULTS: The percentage of saturated FAs (r = 0.30, P = 0.01) and omega-6 FAs (r = -0.32, P = 0.001) were significantly associated with circulating IL-6, whereas the percentage of omega-3 FAs correlated negatively with C-reactive protein in overweight subjects (P = 0.04). Fatty Acids 37-40 interleukin 6 Homo sapiens 148-152 12906374-5 2003 The interleukin-6 (IL-6) over-production can either be ascribed directly to the tumor (as confirmed by immunohistochemistry) or indirectly accounted for by tumoral production, as a consequence of the high levels of circulating norepinephrine. Norepinephrine 227-241 interleukin 6 Homo sapiens 4-17 12906374-5 2003 The interleukin-6 (IL-6) over-production can either be ascribed directly to the tumor (as confirmed by immunohistochemistry) or indirectly accounted for by tumoral production, as a consequence of the high levels of circulating norepinephrine. Norepinephrine 227-241 interleukin 6 Homo sapiens 19-23 12710894-4 2003 The ability of IL-6 to promote transcription of CRP is mediated, in large part, by activation of the transcription factor STAT3; this activation requires both a tyrosine phosphorylation (mediated by the IL-6 receptor complex) and a serine phosphorylation (Ser-727), the origin of which has been more obscure. Tyrosine 161-169 interleukin 6 Homo sapiens 15-19 12710894-4 2003 The ability of IL-6 to promote transcription of CRP is mediated, in large part, by activation of the transcription factor STAT3; this activation requires both a tyrosine phosphorylation (mediated by the IL-6 receptor complex) and a serine phosphorylation (Ser-727), the origin of which has been more obscure. Serine 232-238 interleukin 6 Homo sapiens 15-19 12710894-4 2003 The ability of IL-6 to promote transcription of CRP is mediated, in large part, by activation of the transcription factor STAT3; this activation requires both a tyrosine phosphorylation (mediated by the IL-6 receptor complex) and a serine phosphorylation (Ser-727), the origin of which has been more obscure. Serine 256-259 interleukin 6 Homo sapiens 15-19 12710894-5 2003 There is new evidence that, when hepatocytes are exposed to IL-6, the consequent serine phosphorylation of STATS is mediated by a signal transduction pathway in which the G-protein Rac-1 plays an obligate role. Serine 81-87 interleukin 6 Homo sapiens 60-64 12721390-7 2003 Conversely, the TRPV1 antagonist capsazepine, as well as calcium chelation by EGTA ablated cytokine (IL-6) production after capsaicin exposure. Egtazic Acid 78-82 interleukin 6 Homo sapiens 101-105 12721390-7 2003 Conversely, the TRPV1 antagonist capsazepine, as well as calcium chelation by EGTA ablated cytokine (IL-6) production after capsaicin exposure. Capsaicin 124-133 interleukin 6 Homo sapiens 101-105 12735689-0 2003 Anti-inflammatory mode of isoflavone glycoside sophoricoside by inhibition of interleukin-6 and cyclooxygenase-2 in inflammatory response. isoflavone glycoside sophoricoside 26-60 interleukin 6 Homo sapiens 78-91 12693944-0 2003 Arachidonic acid-induced IL-6 expression is mediated by PKC alpha activation in osteoblastic cells. Arachidonic Acid 0-16 interleukin 6 Homo sapiens 25-29 12693944-2 2003 We found that arachidonic acid (AA) triggers a cell signal in osteoblasts and leads to the expression of IL-6. Arachidonic Acid 14-30 interleukin 6 Homo sapiens 105-109 12527286-3 2003 The production of interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha were enhanced by all metal ions tested as determined by enzyme-linked immunosorbent assay. Metals 104-109 interleukin 6 Homo sapiens 37-82 12697042-7 2003 Similar to IL-6, both constitutive and IL-1beta-inducible IL-11 release were dose-dependently inhibited by cortisol (P<0.01); at variance with IL-6, exogenous IL-11 dose-dependently decreased GR numbers in MG-63 cells (P<0.05), while anti-IL-11 antibody significantly increased GR numbers in both cell lines (P<0.05). Hydrocortisone 107-115 interleukin 6 Homo sapiens 11-15 12875719-8 2003 The increase in IgG, anti-dsDNA and IL-6 protein levels induced by IL-17 was dose-dependent and could be completely blocked by IL-17 monoclonal antibody mIgG(28) and partially blocked by dexamethasone. Dexamethasone 187-200 interleukin 6 Homo sapiens 36-40 12679464-9 2003 Treatment of fetal membranes with NAC significantly suppressed lipopolysaccharide-stimulated type II phospholipase A(2) release and content; PGF(2alpha), IL-6, IL-8, TNFalpha, and 8-isoprostane release; and matrix metalloproteinase-9 and urokinase-type plasminogen activator enzyme activity and suppressed NF-kappaB DNA-binding activity (by ANOVA, P < 0.05). Acetylcysteine 34-37 interleukin 6 Homo sapiens 154-158 12657978-4 2003 RECENT FINDINGS: One key factor that has been identified is excessive production of nitric oxide and related species, although other factors, such as increased expression of the cytokine interleukin 6, appear to be important as well. Nitric Oxide 84-96 interleukin 6 Homo sapiens 187-200 12626585-3 2003 Pretreatment of macrophages with PMA or the proinflammatory mediators LPS and TNF-alpha blocks IL-6-induced STAT3 activation, whereas IL-10-induced activation of STAT3 remains largely unaffected. Tetradecanoylphorbol Acetate 33-36 interleukin 6 Homo sapiens 95-99 12701065-6 2003 In control cells, treatment with linoleic acid reduced intracellular glutathione levels and induced the DNA binding activity of nuclear factor-kappaB (NF-kappaB) leading to the upregulation of interleukin-6 (IL-6). Linoleic Acid 33-46 interleukin 6 Homo sapiens 193-206 12701065-6 2003 In control cells, treatment with linoleic acid reduced intracellular glutathione levels and induced the DNA binding activity of nuclear factor-kappaB (NF-kappaB) leading to the upregulation of interleukin-6 (IL-6). Linoleic Acid 33-46 interleukin 6 Homo sapiens 208-212 12701065-8 2003 In contrast, enrichment with cholesterol enhanced glutathione levels and reduced the linoleic acid-induced activation of NF-kappaBand the production of IL-6. Cholesterol 29-40 interleukin 6 Homo sapiens 152-156 12701065-8 2003 In contrast, enrichment with cholesterol enhanced glutathione levels and reduced the linoleic acid-induced activation of NF-kappaBand the production of IL-6. Linoleic Acid 85-98 interleukin 6 Homo sapiens 152-156 12690457-3 2003 Furthermore, cultured human primary muscle cells can increase IL-6 mRNA when incubated with the calcium ionophore ionomycin and it is likely that myocytes produce IL-6 in response to muscle contraction. Calcium 96-103 interleukin 6 Homo sapiens 62-66 12690457-3 2003 Furthermore, cultured human primary muscle cells can increase IL-6 mRNA when incubated with the calcium ionophore ionomycin and it is likely that myocytes produce IL-6 in response to muscle contraction. Ionomycin 114-123 interleukin 6 Homo sapiens 62-66 12573295-5 2003 GC sensitivity was assessed by dexamethasone (DEX) inhibition of lipopolysaccharide (LPS) stimulated production of interleukin-6 (IL-6) in whole blood, immediately before, as well as 10 and 60 min after the stress test. Dexamethasone 31-44 interleukin 6 Homo sapiens 115-128 12573295-5 2003 GC sensitivity was assessed by dexamethasone (DEX) inhibition of lipopolysaccharide (LPS) stimulated production of interleukin-6 (IL-6) in whole blood, immediately before, as well as 10 and 60 min after the stress test. Dexamethasone 31-44 interleukin 6 Homo sapiens 130-134 12573295-5 2003 GC sensitivity was assessed by dexamethasone (DEX) inhibition of lipopolysaccharide (LPS) stimulated production of interleukin-6 (IL-6) in whole blood, immediately before, as well as 10 and 60 min after the stress test. Dexamethasone 46-49 interleukin 6 Homo sapiens 115-128 12573295-5 2003 GC sensitivity was assessed by dexamethasone (DEX) inhibition of lipopolysaccharide (LPS) stimulated production of interleukin-6 (IL-6) in whole blood, immediately before, as well as 10 and 60 min after the stress test. Dexamethasone 46-49 interleukin 6 Homo sapiens 130-134 12850133-1 2003 Interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) are produced by hepatic nonparenchymal cells after systemic injury and have been reported to inhibit ATP synthesis in hepatocytes, which may contribute to hepatic dysfunction in inflammatory states. Adenosine Triphosphate 155-158 interleukin 6 Homo sapiens 33-46 12850133-1 2003 Interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) are produced by hepatic nonparenchymal cells after systemic injury and have been reported to inhibit ATP synthesis in hepatocytes, which may contribute to hepatic dysfunction in inflammatory states. Adenosine Triphosphate 155-158 interleukin 6 Homo sapiens 48-52 12850133-6 2003 IL-6 did not reduce mitochondrial OUR coupled to ATP synthesis, but shifted the control for ATP synthesis towards processes which generate the MMP, indicating that IL-6 induces a metabolic state where cellular functions are limited by the mitochondrial energy supply. Adenosine Triphosphate 92-95 interleukin 6 Homo sapiens 0-4 12850133-6 2003 IL-6 did not reduce mitochondrial OUR coupled to ATP synthesis, but shifted the control for ATP synthesis towards processes which generate the MMP, indicating that IL-6 induces a metabolic state where cellular functions are limited by the mitochondrial energy supply. Adenosine Triphosphate 92-95 interleukin 6 Homo sapiens 164-168 12626585-7 2003 In contrast to the IL-6 signal transducer gp130, which has been previously shown to recruit SOCS3 to one of its phosphotyrosine residues (Y759), peptide precipitation experiments suggest that SOCS3 does not interact with phosphorylated tyrosine motifs of the IL-10R. Tyrosine 119-127 interleukin 6 Homo sapiens 19-23 12606524-7 2003 Analysis of single cytokines revealed IL-6 as an independent predictor of type 2 diabetes after adjustment for age, sex, BMI, waist-to-hip ratio (WHR), sports, smoking status, educational attainment, alcohol consumption, and HbA(1c) (4th vs. the 1st quartile: odds ratio [OR] 2.6, 95% CI 1.2-5.5). Alcohols 200-207 interleukin 6 Homo sapiens 38-42 12594059-0 2003 Bradykinin induces interleukin-6 production in human airway smooth muscle cells: modulation by Th2 cytokines and dexamethasone. Dexamethasone 113-126 interleukin 6 Homo sapiens 19-32 12594059-5 2003 Actinomycin D (a transcription inhibitor), dexamethasone, indomethacin, IL-4, and IL-13 (Th(2) type cytokines) inhibited the expression of IL-6 by BK. Dexamethasone 43-56 interleukin 6 Homo sapiens 139-143 12594059-6 2003 In contrast, BK-induced IL-6 secretion was enhanced by exogenous prostaglandin E(2) and salmeterol. Dinoprostone 65-83 interleukin 6 Homo sapiens 24-28 12594059-11 2003 Curcumin, an inhibitor of AP-1, also reduced BK-induced IL-6 expression. Curcumin 0-8 interleukin 6 Homo sapiens 56-60 12715892-5 2003 We found that even short synthetic octapeptides can be stimulatory (in the absence of IL-6) or inhibitory (in the presence of IL-6) in both assays. octapeptides 35-47 interleukin 6 Homo sapiens 126-130 12522661-3 2003 The aim of this study was to evaluate the effect of etidronate (10-4-10-9 M) and alendronate (10-7-10-12 M) on the production of IL-6 and IL-11 using human osteoblast cultures. Etidronic Acid 52-62 interleukin 6 Homo sapiens 129-133 12590978-7 2003 Additionally, IL-6 genotype was related to the length of oxygen (O(2)) supplementation and hospital stay, IL-10 genotype to the frequency of pneumonia, and TGF-beta1 genotype to O(2) saturations at presentation. Oxygen 57-63 interleukin 6 Homo sapiens 14-18 21432109-12 2003 IL-6 was weakly correlated with alcohol consumption level in this population. Alcohols 32-39 interleukin 6 Homo sapiens 0-4 12590978-7 2003 Additionally, IL-6 genotype was related to the length of oxygen (O(2)) supplementation and hospital stay, IL-10 genotype to the frequency of pneumonia, and TGF-beta1 genotype to O(2) saturations at presentation. Oxygen 65-70 interleukin 6 Homo sapiens 14-18 12590978-7 2003 Additionally, IL-6 genotype was related to the length of oxygen (O(2)) supplementation and hospital stay, IL-10 genotype to the frequency of pneumonia, and TGF-beta1 genotype to O(2) saturations at presentation. Oxygen 65-69 interleukin 6 Homo sapiens 14-18 12433870-2 2003 In vitro dexamethasone inhibition of LPS-induced interleukin-6 secretion in cultures of peripheral monocytes was compared in untrained subjects (UT) and in endurance-trained men (ET) at the end of a 2-h run and during exercise recovery. Dexamethasone 9-22 interleukin 6 Homo sapiens 49-62 12576215-6 2003 When DGHT (1mg/ml) was added, the secretion of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 was inhibited by 60.1, 81.8, 72.5%, respectively in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated HMC-1 cells. Tetradecanoylphorbol Acetate 166-197 interleukin 6 Homo sapiens 109-113 12576215-6 2003 When DGHT (1mg/ml) was added, the secretion of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 was inhibited by 60.1, 81.8, 72.5%, respectively in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated HMC-1 cells. Tetradecanoylphorbol Acetate 199-202 interleukin 6 Homo sapiens 109-113 12809165-5 2003 In obese women, the vascular and rheological responses to L-arginine were significantly lower (p < 0.05) at baseline, as compared with non-obese women, indicating endothelial dysfunction; on the contrary, basal concentrations of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) were significantly higher (p < 0.01). Arginine 58-68 interleukin 6 Homo sapiens 276-289 12809165-5 2003 In obese women, the vascular and rheological responses to L-arginine were significantly lower (p < 0.05) at baseline, as compared with non-obese women, indicating endothelial dysfunction; on the contrary, basal concentrations of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) were significantly higher (p < 0.01). Arginine 58-68 interleukin 6 Homo sapiens 291-295 12576215-6 2003 When DGHT (1mg/ml) was added, the secretion of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 was inhibited by 60.1, 81.8, 72.5%, respectively in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated HMC-1 cells. Calcium 209-216 interleukin 6 Homo sapiens 109-113 12729473-12 2003 Dexamethasone but not dihydrotestosterone and progesterone decreased IL-6 and PTHrP secretion. Dexamethasone 0-13 interleukin 6 Homo sapiens 69-73 12610804-7 2003 IL-6 concentration was significantly decreased 72 weeks after etidronate administration. Etidronic Acid 62-72 interleukin 6 Homo sapiens 0-4 12610804-10 2003 CONCLUSION: Etidronate was effective at inhibiting bone resorption and destruction in study patients with RA, while not increasing BAP concentrations; and a correlation was observed between the concentration of DPD and IL-6, indicating the antiinflammatory effect of etidronate. Etidronic Acid 12-22 interleukin 6 Homo sapiens 219-223 12729473-12 2003 Dexamethasone but not dihydrotestosterone and progesterone decreased IL-6 and PTHrP secretion. Progesterone 46-58 interleukin 6 Homo sapiens 69-73 12675201-8 2003 In addition, PUAE (0.1 and 1 mg/mL) inhibited the secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated HMC-1 cells. Tetradecanoylphorbol Acetate 126-157 interleukin 6 Homo sapiens 104-122 12393461-5 2003 Curcumin also down-regulated the expression of NF-kappaB-regulated gene products, including IkappaBalpha, Bcl-2, Bcl-x(L), cyclin D1, and interleukin-6. Curcumin 0-8 interleukin 6 Homo sapiens 138-151 12540635-7 2003 The rates of both oxidative (P = 0.013) and nonoxidative (P = 0.016) glucose disposal were significantly affected by the IL-6 promoter polymorphism. Glucose 69-76 interleukin 6 Homo sapiens 121-125 12562325-4 2003 The addition of increasing amounts of allergen during DC maturation with tumour necrosis factor-alpha, IL-1beta and prostaglandin E2 resulted in enhanced secretion of IL-6 and IL-12 by DC followed by increased production of Th1 (interferon-gamma; IFN-gamma) as well as Th2 (IL-4, IL-5) cytokines by CD4+ T cells. Dinoprostone 116-132 interleukin 6 Homo sapiens 167-171 12578976-0 2003 Differential effects of prostaglandin derived from omega-6 and omega-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion. Prostaglandins 24-37 interleukin 6 Homo sapiens 123-127 12535753-8 2003 HDL cholesterol correlated inversely with IL-6, M-CSF, E-selectin, and HOMA IR. Cholesterol 4-15 interleukin 6 Homo sapiens 42-46 12675201-8 2003 In addition, PUAE (0.1 and 1 mg/mL) inhibited the secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated HMC-1 cells. Tetradecanoylphorbol Acetate 159-162 interleukin 6 Homo sapiens 104-122 12682431-0 2003 Induction of interleukin-6 by coal containing bioavailable iron is through both hydroxyl radical and ferryl species. Iron 59-63 interleukin 6 Homo sapiens 13-26 12682431-7 2003 The enhancing effect on the IL-6 by the PA coal was similar to that caused by hydrogen peroxide. Hydrogen Peroxide 78-95 interleukin 6 Homo sapiens 28-32 12682431-10 2003 Our results indicate that BAI in the PA coal may induce IL-6 through both ferryl species (via iron autoxidation) and hydroxyl radicals (via the Fenton/Haber Weiss reactions). Iron 94-98 interleukin 6 Homo sapiens 56-60 12574550-0 2003 Interleukin-6 promoter polymorphism modulates the effects of heavy alcohol consumption on early carotid artery atherosclerosis: the Carotid Atherosclerosis Progression Study (CAPS). Alcohols 67-74 interleukin 6 Homo sapiens 0-13 12581572-13 2003 Correlative data showed a trend towards decreased plasma IL-6 and TNF-alpha after each cycle of therapy presumably due to the dexamethasone premedication and/or paclitaxel. Dexamethasone 126-139 interleukin 6 Homo sapiens 57-61 12581572-13 2003 Correlative data showed a trend towards decreased plasma IL-6 and TNF-alpha after each cycle of therapy presumably due to the dexamethasone premedication and/or paclitaxel. Paclitaxel 161-171 interleukin 6 Homo sapiens 57-61 12574550-6 2003 Interactions were seen between genotype and alcohol consumption for both IL-6 levels and CCA-IMT. Alcohols 44-51 interleukin 6 Homo sapiens 73-77 12574550-7 2003 In individuals who drank >30 g/d of alcohol, the CC genotype was associated with higher IL-6 levels, elevated CCA-IMT (P=0.001), and increased risk of carotid plaque (OR, 3.64; 95% CI, 1.15 to 11.54; P=0.028). Alcohols 39-46 interleukin 6 Homo sapiens 91-95 12574550-9 2003 CONCLUSIONS: These data suggest that the IL-6-174 promotor polymorphism may modulate the effects of alcohol on carotid atherosclerosis. Alcohols 100-107 interleukin 6 Homo sapiens 41-45 12480667-8 2003 PEG precipitates from SLE sera also induced significantly increased levels of IL10 (p=0.016) and IL6 (p=0.042) in comparison with control PEG precipitates. Polyethylene Glycols 0-3 interleukin 6 Homo sapiens 97-100 15206740-9 2003 These data demonstrate an altered TRP metabolism in a subgroup of FM patients, where the TD seems to activate 5-HT metabolism and IL-6 production. Tryptophan 34-37 interleukin 6 Homo sapiens 130-134 12403768-0 2003 SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130. Tyrosine 29-32 interleukin 6 Homo sapiens 62-75 12403768-2 2003 Tyrosine 759 of the IL-6 signal-transducing receptor subunit gp130 has been identified as being involved in negative regulation of IL-6-induced gene induction and activation of the Jak/STAT pathway. Tyrosine 0-8 interleukin 6 Homo sapiens 20-24 12403768-2 2003 Tyrosine 759 of the IL-6 signal-transducing receptor subunit gp130 has been identified as being involved in negative regulation of IL-6-induced gene induction and activation of the Jak/STAT pathway. Tyrosine 0-8 interleukin 6 Homo sapiens 131-135 14686092-6 2003 However, it is clear that IL-6 production is activated by intracellular calcium levels, mitogen-activated protein kinases, reduced glycogen availability and other cytokines such as IL-1 beta. Calcium 72-79 interleukin 6 Homo sapiens 26-30 12520569-7 2003 RESULTS: Serum IL-6 levels were significantly lower in the steroid group than in the control group 24 h after surgery. Steroids 59-66 interleukin 6 Homo sapiens 15-19 12520569-10 2003 CONCLUSIONS: Steroid administration suppresses serum IL-6 levels, but has no effect on short-term outcome. Steroids 13-20 interleukin 6 Homo sapiens 53-57 12788054-7 2003 Hydrocortisone at a dose, which inhibits cell death also down regulated, the expression of pro-inflammatory cytokines IL-6 and IL-8. Hydrocortisone 0-14 interleukin 6 Homo sapiens 118-122 12570760-4 2003 Through A(2B) receptors adenosine seems to cause mast cells degranulation, vasodilation, cardiac fibroblast proliferation, inhibition of Tumor Necrosis Factor (TNF-alpha), increased synthesis of interleukin-6 (IL-6), stimulation of Cl(-) secretion in intestinal epithelia and hepatic glucose production. Adenosine 24-33 interleukin 6 Homo sapiens 195-208 12570760-4 2003 Through A(2B) receptors adenosine seems to cause mast cells degranulation, vasodilation, cardiac fibroblast proliferation, inhibition of Tumor Necrosis Factor (TNF-alpha), increased synthesis of interleukin-6 (IL-6), stimulation of Cl(-) secretion in intestinal epithelia and hepatic glucose production. Adenosine 24-33 interleukin 6 Homo sapiens 210-214 14686093-6 2003 IL-6 can enhance lipolysis in humans and might play a role in glucose metabolism. Glucose 62-69 interleukin 6 Homo sapiens 0-4 14686093-9 2003 Because carbohydrate ingestion during exercise has been demonstrated to blunt the IL-6 and hormonal response, it might also blunt other beneficial adaptations. Carbohydrates 8-20 interleukin 6 Homo sapiens 82-86 12509497-1 2003 In this study, the hypothesis that the release of interleukin (IL)-6 from human muscle is linked to exercise intensity and muscle glucose uptake was investigated. Glucose 130-137 interleukin 6 Homo sapiens 50-68 12608645-8 2003 Reduction in prostanoid levels by NS-398 was accompanied by a reduction in IL-6 secretion levels triggered by CD40 ligation. Prostaglandins 13-23 interleukin 6 Homo sapiens 75-79 12608645-9 2003 Furthermore, exogenously added PGE2 triggered a dose-dependent IL-6 secretion, which was unaffected by NS-398. Dinoprostone 31-35 interleukin 6 Homo sapiens 63-67 12508155-7 2003 There was a significant inverse correlation between DHEA-S and IL-6 plasma levels. Dehydroepiandrosterone Sulfate 52-58 interleukin 6 Homo sapiens 63-67 12447990-3 2003 High serum levels of certain cytokines, for example interleukin-6 (IL-6), have been associated with poor prognosis and cisplatin resistance in various forms of cancer. Cisplatin 119-128 interleukin 6 Homo sapiens 52-65 12447990-3 2003 High serum levels of certain cytokines, for example interleukin-6 (IL-6), have been associated with poor prognosis and cisplatin resistance in various forms of cancer. Cisplatin 119-128 interleukin 6 Homo sapiens 67-71 12447990-7 2003 Curcumin inhibited the production of IL-6 in this cell suggesting that one of the mechanisms for synergy between cisplatin and curcumin was by reducing the autologous production of IL-6. Curcumin 0-8 interleukin 6 Homo sapiens 37-41 12447990-7 2003 Curcumin inhibited the production of IL-6 in this cell suggesting that one of the mechanisms for synergy between cisplatin and curcumin was by reducing the autologous production of IL-6. Curcumin 0-8 interleukin 6 Homo sapiens 181-185 12447990-7 2003 Curcumin inhibited the production of IL-6 in this cell suggesting that one of the mechanisms for synergy between cisplatin and curcumin was by reducing the autologous production of IL-6. Cisplatin 113-122 interleukin 6 Homo sapiens 37-41 12447990-7 2003 Curcumin inhibited the production of IL-6 in this cell suggesting that one of the mechanisms for synergy between cisplatin and curcumin was by reducing the autologous production of IL-6. Cisplatin 113-122 interleukin 6 Homo sapiens 181-185 12447990-7 2003 Curcumin inhibited the production of IL-6 in this cell suggesting that one of the mechanisms for synergy between cisplatin and curcumin was by reducing the autologous production of IL-6. Curcumin 127-135 interleukin 6 Homo sapiens 37-41 12447990-7 2003 Curcumin inhibited the production of IL-6 in this cell suggesting that one of the mechanisms for synergy between cisplatin and curcumin was by reducing the autologous production of IL-6. Curcumin 127-135 interleukin 6 Homo sapiens 181-185 12496440-6 2003 Arg-Gly-Asp-Ser peptide and neo-glycoproteins galactose-BSA and mannose-BSA inhibited the Der f-induced IL-6 and TNF-alpha productions and enhanced accessory function of AMs. Serine 12-15 interleukin 6 Homo sapiens 104-108 12560891-4 2003 We investigated the effect of thalidomide on titanium (Ti) particle-induced TNFalpha and IL-6 production by both human macrophage U937 and osteoblast MG-63 cell lines. Titanium 45-53 interleukin 6 Homo sapiens 89-93 12591236-0 2003 Cyclic AMP inhibits production of interleukin-6 and migration in human vascular smooth muscle cells. Cyclic AMP 0-10 interleukin 6 Homo sapiens 34-47 12591236-3 2003 We recently demonstrated that interleukin-6 (IL-6) was chemotactic to VSMC. vsmc 70-74 interleukin 6 Homo sapiens 30-43 12509497-5 2003 Also, thigh IL-6 release (0.4 +/- 0.1, 1.3 +/- 0.5, 1.5 +/- 0.6 and 2.5 +/- 0.7 ng min(-1) thigh(-1) at rest and 25 %, 65 % and 85 % W(max), respectively) and thigh glucose uptake (0.05 +/- 0.01, 0.3 +/- 0.05, 0.75 +/- 0.16, 1.07 +/- 0.15 mmol min(-1) thigh(-1) at rest and 25 %, 65 % and 85 % W(max), respectively) increased with increasing exercise intensity (P < 0.05). Glucose 165-172 interleukin 6 Homo sapiens 12-16 12591236-3 2003 We recently demonstrated that interleukin-6 (IL-6) was chemotactic to VSMC. vsmc 70-74 interleukin 6 Homo sapiens 45-49 12591236-4 2003 Therefore, we tested the hypothesis that elevating cyclic AMP would inhibit TNF-alpha-mediated IL-6 expression and VSMC migration. Cyclic AMP 51-61 interleukin 6 Homo sapiens 95-99 12509497-7 2003 During exercise, thigh IL-6 release was positively related to both thigh glucose uptake (P < 0.001) and thigh glucose delivery (P < 0.005), but not to thigh glucose extraction. Glucose 73-80 interleukin 6 Homo sapiens 23-27 12591236-15 2003 CONCLUSIONS: These data show that IL-6 produced by VSMC contributes to cell migration induced by TNF-alpha. vsmc 51-55 interleukin 6 Homo sapiens 34-38 12591236-16 2003 Further, elevating cyclic AMP inhibited TNF-alpha-induced release of IL-6, and migration of VSMC. Cyclic AMP 19-29 interleukin 6 Homo sapiens 69-73 12509497-7 2003 During exercise, thigh IL-6 release was positively related to both thigh glucose uptake (P < 0.001) and thigh glucose delivery (P < 0.005), but not to thigh glucose extraction. Glucose 113-120 interleukin 6 Homo sapiens 23-27 12509497-7 2003 During exercise, thigh IL-6 release was positively related to both thigh glucose uptake (P < 0.001) and thigh glucose delivery (P < 0.005), but not to thigh glucose extraction. Glucose 113-120 interleukin 6 Homo sapiens 23-27 12509497-10 2003 In conclusion, the study indicates that IL-6 release from human muscle is positively related to exercise intensity, arterial adrenaline concentration and muscle glucose uptake. Glucose 161-168 interleukin 6 Homo sapiens 40-44 12509497-12 2003 The observation of a relationship between IL-6 release and muscle glycogen store both at rest and after exercise suggests that IL-6 may act as a carbohydrate sensor. Carbohydrates 145-157 interleukin 6 Homo sapiens 42-46 12509497-12 2003 The observation of a relationship between IL-6 release and muscle glycogen store both at rest and after exercise suggests that IL-6 may act as a carbohydrate sensor. Carbohydrates 145-157 interleukin 6 Homo sapiens 127-131 12899535-1 2003 Calcitriol, the hormonal form of vitamin D, enhances the anticancer activity of the immune cytokine tumor necrosis factor, interleukin 1 and interleukin 6 in human breast and renal cell carcinoma cells without affecting the cytotoxic action of interferon-alpha or killer lymphocytes. Vitamin D 33-42 interleukin 6 Homo sapiens 141-154 12417965-9 2003 Estradiol concentrations correlated positively with IL-6 levels. Estradiol 0-9 interleukin 6 Homo sapiens 52-56 12639008-0 2003 The use of IL-6 induction as a human biomarker for inflammatory agents in water. Water 74-79 interleukin 6 Homo sapiens 11-15 12556010-4 2003 We therefore investigated whether 8-Bromo-cAMP, a cell membrane-permeable cAMP analogue, would influence release of the cytokines interleukin-6 (IL-6) and IL-8 in a human airway epithelial cell line, A549, exposed to a suspension of the organic dust, and to a supernatant prepared by centrifugation (at low g-force) of a suspension of dust. Cyclic AMP 42-46 interleukin 6 Homo sapiens 130-143 12556010-4 2003 We therefore investigated whether 8-Bromo-cAMP, a cell membrane-permeable cAMP analogue, would influence release of the cytokines interleukin-6 (IL-6) and IL-8 in a human airway epithelial cell line, A549, exposed to a suspension of the organic dust, and to a supernatant prepared by centrifugation (at low g-force) of a suspension of dust. Cyclic AMP 42-46 interleukin 6 Homo sapiens 145-149 12729367-4 2003 It has been hypothesized that the link between cisplatin treatment and FMF attacks lies in an increased production of serotonin, IL-6, IL-1, IL-8 and TNF-alpha. Cisplatin 47-56 interleukin 6 Homo sapiens 129-133 12639008-4 2003 Water contaminated with inflammatory substances induced the pro-inflammatory hormone interleukin 6 (IL-6). Water 0-5 interleukin 6 Homo sapiens 85-98 12639008-4 2003 Water contaminated with inflammatory substances induced the pro-inflammatory hormone interleukin 6 (IL-6). Water 0-5 interleukin 6 Homo sapiens 100-104 12639008-5 2003 All water samples collected from the Modder River induced IL-6 secretion, and the quantity of IL-6 secreted was dependent on the concentration and origin of the sample. Water 4-9 interleukin 6 Homo sapiens 58-62 12471139-6 2002 Depletion of tryptophan led to stabilization of IL-6 and IL-8 mRNA and increased IL-6 and IL-8 responses, whereas supplementing tryptophan largely restored these changes. Tryptophan 13-23 interleukin 6 Homo sapiens 48-52 12471139-6 2002 Depletion of tryptophan led to stabilization of IL-6 and IL-8 mRNA and increased IL-6 and IL-8 responses, whereas supplementing tryptophan largely restored these changes. Tryptophan 13-23 interleukin 6 Homo sapiens 81-85 12483530-10 2002 Protection from dexamethasone-induced apoptosis correlates with IL-6 concentration and Ras activation. Dexamethasone 16-29 interleukin 6 Homo sapiens 64-68 12483530-11 2002 However, IL-6 enhances apoptosis induced by doxorubicin. Doxorubicin 44-55 interleukin 6 Homo sapiens 9-13 12534448-7 2002 Plasma levels of both IL-6 and ICAM-1 were reduced in patients taking aspirin. Aspirin 70-77 interleukin 6 Homo sapiens 22-26 12550104-0 2002 IL-6 enhances IgE-dependent histamine release from human peripheral blood-derived cultured mast cells. Histamine 28-37 interleukin 6 Homo sapiens 0-4 12550104-1 2002 We examined whether interleukin (IL)-6 exerts the stimulatory effects on the secretion of histamine from human mast cells triggered by crosslinking of the high affinity IgE receptor (FcepsilonRI) with IgE and anti-IgE. Histamine 90-99 interleukin 6 Homo sapiens 20-38 12550104-3 2002 Incubation with SCF+IL-6 for 1 week increased the IgE-dependent release as well as intracellular content of histamine in the cultured mast cells, as compared with the values obtained by incubation with SCF alone. Histamine 108-117 interleukin 6 Homo sapiens 20-24 12550104-7 2002 When SCF, IL-6 and IL-4 were used together, a further increase was observed in the anti-IgE-dependent liberation of histamine from the cultured mast cells, compared with the two-factor combinations. Histamine 116-125 interleukin 6 Homo sapiens 10-14 12534448-2 2002 The aim of this study was to explore if prior aspirin therapy in unstable angina (UA) patients could modify systemic inflammatory markers such as interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha) and intercellular adhesion molecule-1 (ICAM-1) and the expression of endothelial nitric oxide synthase (eNOS) in neutrophils. Aspirin 46-53 interleukin 6 Homo sapiens 146-159 12388119-2 2002 We hypothesized that the skeletal muscle will release IL-6, but not TNF-alpha, during exercise because of previous observations that TNF-alpha negatively affects glucose uptake in skeletal muscle. Glucose 162-169 interleukin 6 Homo sapiens 54-58 12504270-6 2002 Arg administration significantly increased ALP, NO, PICP and IGF-I production and reduced the level of IL-6. Arginine 0-3 interleukin 6 Homo sapiens 103-107 12452835-6 2002 In the A549 cells, gp-340 was up-regulated along with the PMA-induced proinflammatory expression of both IL-6 and IL-8. Tetradecanoylphorbol Acetate 58-61 interleukin 6 Homo sapiens 105-109 12453891-6 2002 The IL-6 effect is characterized by a decreased tyrosine phosphorylation of IR substrate (IRS)-1 and decreased association of the p85 subunit of phosphatidylinositol 3-kinase with IRS-1 in response to physiologic insulin levels. Tyrosine 48-56 interleukin 6 Homo sapiens 4-8 12534448-2 2002 The aim of this study was to explore if prior aspirin therapy in unstable angina (UA) patients could modify systemic inflammatory markers such as interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha) and intercellular adhesion molecule-1 (ICAM-1) and the expression of endothelial nitric oxide synthase (eNOS) in neutrophils. Aspirin 46-53 interleukin 6 Homo sapiens 161-165 12235142-2 2002 Interleukin-6 (IL-6) initiates STAT3 signaling in plasma membrane rafts with the subsequent transit of Tyr-phosphorylated STAT3 (PY-STAT3) through the cytoplasmic compartment to the nucleus in association with accessory proteins. Tyrosine 103-106 interleukin 6 Homo sapiens 0-13 12468642-3 2002 Steroid-dependent secretion of IL-6 was analysed by 17beta-estradiol (10(-8) mol/l) or progesterone (10(-6) mol/l) treatment and withdrawal (n = 8). Progesterone 87-99 interleukin 6 Homo sapiens 31-35 12468642-3 2002 Steroid-dependent secretion of IL-6 was analysed by 17beta-estradiol (10(-8) mol/l) or progesterone (10(-6) mol/l) treatment and withdrawal (n = 8). Steroids 0-7 interleukin 6 Homo sapiens 31-35 12468642-3 2002 Steroid-dependent secretion of IL-6 was analysed by 17beta-estradiol (10(-8) mol/l) or progesterone (10(-6) mol/l) treatment and withdrawal (n = 8). Estradiol 52-68 interleukin 6 Homo sapiens 31-35 12235142-2 2002 Interleukin-6 (IL-6) initiates STAT3 signaling in plasma membrane rafts with the subsequent transit of Tyr-phosphorylated STAT3 (PY-STAT3) through the cytoplasmic compartment to the nucleus in association with accessory proteins. Tyrosine 103-106 interleukin 6 Homo sapiens 15-19 12213453-1 2002 Solid phase peptide library screening followed by extension of a lead recognition element for binding to a dsDNA sequence (NF binding site of IL6) using solution phase screening, delivered a new DNA binding peptide, Ac-Arg-Ual-Sar-Chi-Chi-Tal-Arg-CONH2. Arginine 219-222 interleukin 6 Homo sapiens 142-145 12379903-9 2002 After binding with gp130, the IL-6 receptor matures and can accept IL-6 molecules. 2-phenyl-5,5-dimethyltetrahydro-1,4-oxazine 19-24 interleukin 6 Homo sapiens 30-34 12379903-9 2002 After binding with gp130, the IL-6 receptor matures and can accept IL-6 molecules. 2-phenyl-5,5-dimethyltetrahydro-1,4-oxazine 19-24 interleukin 6 Homo sapiens 67-71 12360405-9 2002 These results indicate that the MAPK pathway plays a critical role in IL-6 mediated tyrosine phosphorylation of STAT3 and suggests that Jak kinases may not be required in this cascade. Tyrosine 84-92 interleukin 6 Homo sapiens 70-74 12429044-7 2002 The increase of cortisol relative to DHEA appears 4 h after endotoxin injection and 2 h after a strong increase of interleukin (IL)-6 relative to tumour necrosis factor (TNF). Hydrocortisone 16-24 interleukin 6 Homo sapiens 115-133 12429044-9 2002 The ratio of serum IL-6/TNF was positively correlated with the ratio of serum cortisol/DHEA (R(Rank)=0.472, P=0.041) and serum cortisol/17OH-progesterone (R(Rank)=0.514, P=0.048). Hydrocortisone 78-86 interleukin 6 Homo sapiens 19-23 12429044-9 2002 The ratio of serum IL-6/TNF was positively correlated with the ratio of serum cortisol/DHEA (R(Rank)=0.472, P=0.041) and serum cortisol/17OH-progesterone (R(Rank)=0.514, P=0.048). Hydrocortisone 127-135 interleukin 6 Homo sapiens 19-23 12379548-4 2002 Melatonin was proinflammatory, causing significantly increased production of interleukin-1, interleukin-6, and tumor necrosis factor-alpha at 4:00 P.M. and 4:00 A.M. in all subject groups (range, 12.8 +/- 3.3 to 131.72 +/- 16.4%, p < or = 0.0003). Melatonin 0-9 interleukin 6 Homo sapiens 92-105 12379575-2 2002 We assessed the role of glucose in the regulation of circulating levels of IL-6, TNF-alpha, and interleukin-18 (IL-18) in subjects with normal or impaired glucose tolerance (IGT), as well as the effect of the antioxidant glutathione. Glucose 24-31 interleukin 6 Homo sapiens 75-79 12509942-8 2002 PPARgamma agonists troglitazone, rosiglitazone, and 15-deoxy-Delta(12, 14)-prosglandin J(2) significantly decreased the upexpression of TNF-alpha and IL-6 in HMCL supernatants stimulated by IL-1beta. Rosiglitazone 33-46 interleukin 6 Homo sapiens 150-154 12556067-0 2002 Generation of TNFalpha and interleukin-6 by peritoneal macrophages after overnight dwells with bicarbonate- or lactate-buffered dialysis fluid. Bicarbonates 95-106 interleukin 6 Homo sapiens 27-40 12556067-0 2002 Generation of TNFalpha and interleukin-6 by peritoneal macrophages after overnight dwells with bicarbonate- or lactate-buffered dialysis fluid. Lactic Acid 111-118 interleukin 6 Homo sapiens 27-40 12482343-8 2002 CONCLUSION: CD(40) ligandization on BMSC increased the production of IL-6 and FL and promoted the proliferation of CD(34)(+) cells. Cadmium 12-14 interleukin 6 Homo sapiens 69-73 12359225-4 2002 Here, we demonstrate that IL-6-induced tyrosine-phosphorylation and activation of STAT3 were suppressed by overexpression of the nuclear isoform of TC-PTP in 293T cells. Tyrosine 39-47 interleukin 6 Homo sapiens 26-30 12357144-8 2002 The early cortisol responses were negatively correlated with the concomitant interleukin-6 serum concentrations (r(2) = 0.298; = 0.003). Hydrocortisone 10-18 interleukin 6 Homo sapiens 77-90 12433058-2 2002 Inhibition of glutathione-oxidized disulfide reductase, which recycles GSSG --> 2GSH, by the action of 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) augmented LPS-dependent secretion of interleukin (IL)-1beta, IL-6 and tumor necrosis factor (TNF)-alpha. Glutathione 14-25 interleukin 6 Homo sapiens 212-216 12358901-2 2002 Cyclooxygenase-2 (Cox-2) converts arachidonic acid to prostaglandins, which induce expression of angiogenic factors, including vascular endothelial growth factor (VEGF), basic-fibroblast growth factor, transforming growth factor-beta and interleukin 6. Arachidonic Acid 34-50 interleukin 6 Homo sapiens 238-251 12358901-2 2002 Cyclooxygenase-2 (Cox-2) converts arachidonic acid to prostaglandins, which induce expression of angiogenic factors, including vascular endothelial growth factor (VEGF), basic-fibroblast growth factor, transforming growth factor-beta and interleukin 6. Prostaglandins 54-68 interleukin 6 Homo sapiens 238-251 12406022-8 2002 CONCLUSION: We suggest that the growth arrest induced by IL-6 is in part mediated by its dual action on histamine: a shift toward H1 receptor predominance and an elevation of locally produced histamine with prevalent action on the inhibitory response triggered through the H1 receptor. Histamine 192-201 interleukin 6 Homo sapiens 57-61 12239628-3 2002 We have investigated whether the IL-6 receptor super-antagonist Sant7 might enhance the antiproliferative and apoptotic effects induced by the combination of dexamethasone (Dex) and zoledronic acid (Zln) on human MM cell lines and primary cells from MM patients. Dexamethasone 158-171 interleukin 6 Homo sapiens 33-37 12239628-3 2002 We have investigated whether the IL-6 receptor super-antagonist Sant7 might enhance the antiproliferative and apoptotic effects induced by the combination of dexamethasone (Dex) and zoledronic acid (Zln) on human MM cell lines and primary cells from MM patients. Dexamethasone 173-176 interleukin 6 Homo sapiens 33-37 12377747-4 2002 IL-6 levels were related to the frequency of alcohol intake (P=0.002) and showed an inverse relationship with exercise frequency and hormone replacement therapy (P<0.0001 for both). Alcohols 45-52 interleukin 6 Homo sapiens 0-4 12377747-8 2002 In multivariate analyses, independent relationships were seen between levels of IL-6 and age, BMI, smoking, systolic blood pressure, alcohol use, presence of diabetes, and frequency of exercise. Alcohols 133-140 interleukin 6 Homo sapiens 80-84 12406022-0 2002 Inhibition of human primary melanoma cell proliferation by histamine is enhanced by interleukin-6. Histamine 59-68 interleukin 6 Homo sapiens 84-97 12406022-4 2002 RESULTS: IL-6 inhibited the proliferation of WM35 melanoma cells and increased significantly the expression of histidine decarboxylase as well as histamine production. Histamine 146-155 interleukin 6 Homo sapiens 9-13 12406022-8 2002 CONCLUSION: We suggest that the growth arrest induced by IL-6 is in part mediated by its dual action on histamine: a shift toward H1 receptor predominance and an elevation of locally produced histamine with prevalent action on the inhibitory response triggered through the H1 receptor. Histamine 104-113 interleukin 6 Homo sapiens 57-61 12239628-0 2002 The IL-6 receptor super-antagonist Sant7 enhances antiproliferative and apoptotic effects induced by dexamethasone and zoledronic acid on multiple myeloma cells. Dexamethasone 101-114 interleukin 6 Homo sapiens 4-8 12145290-7 2002 Finally, we show that interleukin-6 treatment in the presence or absence of overexpressed C/EBPbeta increased the promoter activities of reporter constructs containing nucleoside A at -217 compared with reporter constructs containing nucleoside G at -217. nucleoside g 234-246 interleukin 6 Homo sapiens 22-35 12209879-4 2002 In contrast, proliferation of the IL-6-dependent MM cell line, ANBL-6 was blocked by PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 85-92 interleukin 6 Homo sapiens 34-38 12210475-6 2002 Furthermore, testosterone completely abrogated NF kappa B transactivation activity and induction of IL-6 protein expression and mRNA. Testosterone 13-25 interleukin 6 Homo sapiens 100-104 12115453-7 2002 Dex reduced the release of NO, VEGF, IL-6, MMP-2, and MMP-9. Dexamethasone 0-3 interleukin 6 Homo sapiens 37-41 12210475-3 2002 METHODS: By using enzyme-linked immunosorbent assay analyses, promatrilysin was measured in LNCaP cells stimulated with IL-1 beta or IL-6 LNCaP-treated cells pretreated with testosterone. Testosterone 174-186 interleukin 6 Homo sapiens 133-137 12210475-9 2002 CONCLUSION: From these data, we conclude that testosterone blocks IL-1 beta-induced promatrilysin expression by inhibition of NF kappa B transactivation activity, which in turn, blocks IL-6 expression. Testosterone 46-58 interleukin 6 Homo sapiens 185-189 12210475-4 2002 In addition, promatrilysin message was measured by using Northern analyses after IL-6-treated cells pretreated with testosterone. Testosterone 116-128 interleukin 6 Homo sapiens 81-85 12473263-5 2002 Addition of glucose (100mM) or mannose (100mM), and to some extent galactose (100mM), but not fructose (100mM) to the co-cultures, partly inhibited the monocyte IL-6 co-culture response, but such addition did not inhibit the in vitro monocyte lipopolysaccharide (LPS)-generated IL-6 secretion. Galactose 67-76 interleukin 6 Homo sapiens 161-165 12080047-2 2002 Acting through the adenosine A2b receptor (A2bR), the luminally derived adenosine induces vectorial chloride secretion and a polarized secretion of interleukin-6 to the intestinal lumen. Adenosine 19-28 interleukin 6 Homo sapiens 148-161 12476543-6 2002 Human cord blood CD34+ cells differentiate and grow into mast cells in the presence of stem cell factor (SCF) and IL-6, causing increases in cell size, frequency of chymase positive cells, and intracellular histamine levels when compared with cells treated with SCF alone. Histamine 207-216 interleukin 6 Homo sapiens 114-118 12476543-8 2002 IL-6 also up-regulates histamine production rather than increases its storage and is an important inducing factor for the expression of immunoglobulin E (IgE) Fc epsilon RI. Histamine 23-32 interleukin 6 Homo sapiens 0-4 12208756-7 2002 PTK787 enhances the inhibitory effect of dexamethasone on growth of MM cells and can overcome the protective effect of interleukin 6 (IL-6) against dexamethasone-induced apoptosis. Dexamethasone 148-161 interleukin 6 Homo sapiens 119-132 12208756-7 2002 PTK787 enhances the inhibitory effect of dexamethasone on growth of MM cells and can overcome the protective effect of interleukin 6 (IL-6) against dexamethasone-induced apoptosis. Dexamethasone 148-161 interleukin 6 Homo sapiens 134-138 12353854-8 2002 These results indicate short-chain fatty acids beneficially increase small intestinal abundance of IL-1beta and IL-6 during total parenteral nutrition administration, while not affecting systemic production of these cytokines or intestinal inflammation. Fatty Acids, Volatile 23-46 interleukin 6 Homo sapiens 112-116 12607189-6 2002 RESULTS: Histamine increased the production of IL-1, IL-6 and IL-8, and ICAM-1 expression. Histamine 9-18 interleukin 6 Homo sapiens 53-57 12165085-11 2002 These data indicate that (1) T-HPMC lines mimic the morphological and functional features of P-HPMC, (2) P-HPMC and T-HPMC constituitively produce IL-6 and IL-8, which is enhanced by hIL-1beta and hTNF-alpha and (3) HPMC in vivo may participate in the pathogenesis of benign and malignant gynaecological disease. hydroxypropylmethylcellulose-lactose matrix 31-35 interleukin 6 Homo sapiens 147-151 12205025-3 2002 It appears that intramuscular IL-6 is stimulated by complex signaling cascades initiated by both calcium (Ca2+) -dependent and -independent stimuli. Calcium 97-104 interleukin 6 Homo sapiens 30-34 12173037-1 2002 Interleukin-6 (IL-6) and insulin-like growth factor-1 (IGF-1) promote the proliferation of multiple myeloma (MM) cells and protect them against dexamethasone (Dex)-induced apoptosis. Dexamethasone 144-157 interleukin 6 Homo sapiens 0-13 12173037-1 2002 Interleukin-6 (IL-6) and insulin-like growth factor-1 (IGF-1) promote the proliferation of multiple myeloma (MM) cells and protect them against dexamethasone (Dex)-induced apoptosis. Dexamethasone 144-157 interleukin 6 Homo sapiens 15-19 12173037-1 2002 Interleukin-6 (IL-6) and insulin-like growth factor-1 (IGF-1) promote the proliferation of multiple myeloma (MM) cells and protect them against dexamethasone (Dex)-induced apoptosis. Dexamethasone 159-162 interleukin 6 Homo sapiens 0-13 12173037-1 2002 Interleukin-6 (IL-6) and insulin-like growth factor-1 (IGF-1) promote the proliferation of multiple myeloma (MM) cells and protect them against dexamethasone (Dex)-induced apoptosis. Dexamethasone 159-162 interleukin 6 Homo sapiens 15-19 12183057-2 2002 Induced stability of IL-6 mRNA was markedly decreased by the inhibitors of extracellular signal-regulated kinase (ERKs), PD98059 and U0216. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 121-128 interleukin 6 Homo sapiens 21-25 12162776-4 2002 The inductive effects of proinflammatory cytokines (IL-1alpha or tumor necrosis factor alpha) alone or in combination with prostaglandin E(2) on IL-6 and COX-2 messenger RNA (mRNA) synthesis in NPFs were investigated. Dinoprostone 123-141 interleukin 6 Homo sapiens 145-149 12173037-6 2002 In contrast, the Akt inhibitor IL-6-Hydroxymethyl-chiro-inositol 2-(R)-2-O-methyl-3-O-octadecylcarbonate induced cell death of both Dex- and Doxo-sensitive and -resistant cells; opposed the protective effect of constitutive Akt activity against Apo2L/TRAIL; and abrogated the NF-kappaB activation, increase of anti-apoptotic proteins and protection against Apo2L/TRAIL induced by IGF-1. Dexamethasone 132-135 interleukin 6 Homo sapiens 31-35 12173037-6 2002 In contrast, the Akt inhibitor IL-6-Hydroxymethyl-chiro-inositol 2-(R)-2-O-methyl-3-O-octadecylcarbonate induced cell death of both Dex- and Doxo-sensitive and -resistant cells; opposed the protective effect of constitutive Akt activity against Apo2L/TRAIL; and abrogated the NF-kappaB activation, increase of anti-apoptotic proteins and protection against Apo2L/TRAIL induced by IGF-1. Doxorubicin 141-145 interleukin 6 Homo sapiens 31-35 12181307-10 2002 The temporal profile of the post-exercise change in the IL-6 output closely resembles the changes in the outputs of glycerol and fatty acids, which we have described previously in the same adipose tissue depot. Fatty Acids 129-140 interleukin 6 Homo sapiens 56-60 12181307-12 2002 Thus, we suggest that the enhanced IL-6 production post-exercise in abdominal, subcutaneous adipose tissue may act locally via autocrine/paracrine mechanisms influencing lipolysis and fatty acid mobilization rate from this lipid depot. Fatty Acids 184-194 interleukin 6 Homo sapiens 35-39 12181308-8 2002 It is concluded that IL-6 elicits lipolytic effects in human adipose tissue in vivo, and that IL-6 also has effects on the splanchnic lipid and carbohydrate metabolism. Carbohydrates 144-156 interleukin 6 Homo sapiens 94-98 12163427-4 2002 The purpose of this analysis was to determine whether rosiglitazone alters serum concentrations of CRP, IL-6, MMP-9, and white blood cell count (WBC) and to examine the relationship of these effects with demographic and disease variables. Rosiglitazone 54-67 interleukin 6 Homo sapiens 104-108 12163427-7 2002 The percentage reduction in mean IL-6 was small and similar in the rosiglitazone and placebo groups. Rosiglitazone 67-80 interleukin 6 Homo sapiens 33-37 12143044-3 2002 This study was designed to determine whether there is any relationship between eicosanoid metabolism and growth stimulation by IL-6 and HGF, two important biliary epithelial cell and cholangiocarcinoma mitogens. Eicosanoids 79-89 interleukin 6 Homo sapiens 127-131 12143044-5 2002 HGF and IL-6 also induced a rapid release of arachidonic acid (AA) from SG231 and increased the synthesis of PGE(2) and PGF(2)alpha. Arachidonic Acid 45-61 interleukin 6 Homo sapiens 8-12 12143044-6 2002 The cPLA(2) inhibitor arachidonyl fluorophosphonate (MAFP) and the COX-2 inhibitor NS-398 significantly inhibited HGF- and IL-6-induced release of AA, PG synthesis, and proliferation in SG231 cells as well as two other human cholangiocarcinoma cell lines, HuCCT1 and CC-LP-1 cells. Prostaglandins 151-153 interleukin 6 Homo sapiens 123-127 12182824-5 2002 An increase in the electrophoretic mobility of secreted hIL-6-HlyA(s) in non-reducing SDS-PAGE, similar to that found for recombinant mature hIL-6, and the absence of such a mobility shift in the intracellular hIL-6-HlyA(s) protein fraction indicated that in hIL-6-HlyA(s) most probably correct intramolecular disulfide bond formation occurred during the secretion step. Sodium Dodecyl Sulfate 86-89 interleukin 6 Homo sapiens 56-61 12143044-9 2002 The HGF- and IL-6-induced cPLA(2) phosphorylation was blocked by the inhibitors of p38 and p42/44 MAP kinases, protein kinase C, calmodulin kinase, and tyrosine kinase, showing that HGF- and IL-6-induced AA release and PG production are mediated by phosphorylation of cPLA(2). Prostaglandins 219-221 interleukin 6 Homo sapiens 13-17 12404674-0 2002 Effects of serotonin and catecholamine depletion on interleukin-6 activation and mood in human volunteers. Serotonin 11-20 interleukin 6 Homo sapiens 52-65 12138260-16 2002 CONCLUSIONS: IL-6 and CRP were increased and were inversely related to creatinine clearance in our population of 103 chronic predialytic patients. Creatinine 71-81 interleukin 6 Homo sapiens 13-17 12182824-6 2002 To confirm the disulfide bond formation, hIL-6-HlyA(s) was purified by a single-step immunoaffinity chromatography from culture supernatant in yields of 18 microg/L culture supernatant with purity in the range of 60%. Disulfides 15-24 interleukin 6 Homo sapiens 41-46 12182824-7 2002 These results demonstrate that codon usage has an impact on the hemolysin-mediated secretion of hIL-6 and, furthermore, provide evidence that the hemolysin system enables secretory delivery of disulfide-bridged proteins. Disulfides 193-202 interleukin 6 Homo sapiens 96-101 12161012-4 2002 Evidence from this laboratory and others suggest that the gender difference in immune responses after injury is mediated in part by alterations in the circulating levels of gonadal steroid hormones through modulation of production of inflammatory and immunoregulatory cytokines, including interleukin-6 (IL-6). Steroids 181-197 interleukin 6 Homo sapiens 289-302 12161012-4 2002 Evidence from this laboratory and others suggest that the gender difference in immune responses after injury is mediated in part by alterations in the circulating levels of gonadal steroid hormones through modulation of production of inflammatory and immunoregulatory cytokines, including interleukin-6 (IL-6). Steroids 181-197 interleukin 6 Homo sapiens 304-308 12085250-13 2002 The present study indicates that patients responded to treatment of advanced breast cancer with single-agent paclitaxel or docetaxel leads to an increase in serum IFN-gamma, IL-2, IL-6, GM-CSF cytokine levels and enhancement of PBMC NK and LAK cell activity, while they both lead to a decrease of acute phase serum cytokine levels of IL-1 and TNF-alpha. Paclitaxel 109-119 interleukin 6 Homo sapiens 180-184 12119038-1 2002 Suppressor of cytokine signaling-3 (SOCS-3) and the protein tyrosine phosphatase SHP-2 both regulate signaling by cytokines of the interleukin-6 family, and this is dependent upon recruitment to tyrosine 757 in the shared cytokine receptor subunit gp130. Tyrosine 60-68 interleukin 6 Homo sapiens 131-144 12150965-0 2002 Isoflavones regulate interleukin-6 and osteoprotegerin synthesis during osteoblast cell differentiation via an estrogen-receptor-dependent pathway. Isoflavones 0-11 interleukin 6 Homo sapiens 21-34 12150965-1 2002 The hypothesis tested in this in vitro study was that the expression and production of dietary isoflavone-mediated osteoclastogenesis-regulatory cytokines, such as interleukin-6 (IL-6) and osteoprotegerin (OPG), are related to the different levels of estrogen receptors expressed in two hFOB osteoblastic cell lines. Isoflavones 95-105 interleukin 6 Homo sapiens 164-177 12150965-1 2002 The hypothesis tested in this in vitro study was that the expression and production of dietary isoflavone-mediated osteoclastogenesis-regulatory cytokines, such as interleukin-6 (IL-6) and osteoprotegerin (OPG), are related to the different levels of estrogen receptors expressed in two hFOB osteoblastic cell lines. Isoflavones 95-105 interleukin 6 Homo sapiens 179-183 12150965-4 2002 The increased expression of OPG and decreased IL-6 production by isoflavones were dose-dependent. Isoflavones 65-76 interleukin 6 Homo sapiens 46-50 12150965-6 2002 After adding the ER binding blocker, ICI-182,780, the effects of isoflavones on OPG and IL-6 production disappeared. Isoflavones 65-76 interleukin 6 Homo sapiens 88-92 12150965-7 2002 In summary, the inhibition by dietary isoflavones of IL-6 production and the stimulation of OPG appear to be mediated, at least in part, via a genomic pathway operating through estrogen receptors and gene expression mechanisms. Isoflavones 38-49 interleukin 6 Homo sapiens 53-57 12117719-6 2002 Attenuation of the C pneumoniae-induced activation of NF-kappaB by aspirin also reduced the secretion of interleukin-6 and interleukin-8, indicating efficient inhibition of NF-kappaB gene expression. Aspirin 67-74 interleukin 6 Homo sapiens 105-118 12100148-5 2002 IL-6 expression was determined on paraffin-wax sections of biopsy material by means of an immunohistochemical assay. Paraffin 34-42 interleukin 6 Homo sapiens 0-4 12097303-9 2002 Importantly, IGF-1 and IL-6 abrogate Dex-induced down-regulation of telomerase activity and apoptosis. Dexamethasone 37-40 interleukin 6 Homo sapiens 23-27 12080442-7 2002 Dexamethasone decreased IL-6 secretion and increased leptin secretion in a dose-dependent manner. Dexamethasone 0-13 interleukin 6 Homo sapiens 24-28 12143206-5 2002 The increase in portal interleukin-6 levels during liver resection (time points, ii and iii) significantly correlated with the duration of hepatic inflow occlusion (48 +/- 9 min, mean +/- SD), portal venous pressure (500 +/- 127 mmH2O), and postoperative serum levels of transaminases (day 1; S-ALT, 705 +/- 1023 U/L; S-AST 892 +/- 1255 U/L) and maximum bilirubin (2.6 +/- 2.5 mg/dL). mmh2o 229-234 interleukin 6 Homo sapiens 23-36 12349949-6 2002 Interestingly, H2O2-stimulation not only failed to increase IL-6 production from fibroblasts, but also repressed induction of IL-6 by LPS-stimulation in a dose-dependent manner. Hydrogen Peroxide 15-19 interleukin 6 Homo sapiens 126-130 12080442-9 2002 The effects of dexamethasone and catecholamines on IL-6 and leptin were abrogated by RU486 and propranolol, respectively. Dexamethasone 15-28 interleukin 6 Homo sapiens 51-55 12091569-0 2002 Chronic interleukin-6 exposure alters electrophysiological properties and calcium signaling in developing cerebellar purkinje neurons in culture. Calcium 74-81 interleukin 6 Homo sapiens 8-21 12115737-5 2002 When Caco-2 cells were treated with IL-1beta in the presence of the MAPK inhibitor, PD-98059, IL-6 mRNA and protein levels were reduced by the same concentrations of PD-98059 that inhibited C/EBP DNA binding activity in previous studies. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 166-174 interleukin 6 Homo sapiens 94-98 12091569-4 2002 Two weeks of exposure to 1,000 units/ml (U/ml) IL-6 resulted in altered electrophysiological properties of Purkinje neurons, including a significant reduction in action potential generation, an increase in input resistance, and an enhanced electrical response to the ionotropic glutamate receptor agonist, alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) compared with untreated neurons. -amino-3-hydroxy-5-methylisoxazole-4-propionic acid 311-362 interleukin 6 Homo sapiens 47-51 12091569-6 2002 However, neurons exposed to 500 U/ml chronic IL-6 resulted in significantly elevated resting levels of intracellular calcium as well as an increase in the intracellular calcium signal of Purkinje neurons in response to AMPA, effects not observed in neurons exposed to 1,000 U/ml chronic IL-6. Calcium 117-124 interleukin 6 Homo sapiens 45-49 12091569-6 2002 However, neurons exposed to 500 U/ml chronic IL-6 resulted in significantly elevated resting levels of intracellular calcium as well as an increase in the intracellular calcium signal of Purkinje neurons in response to AMPA, effects not observed in neurons exposed to 1,000 U/ml chronic IL-6. Calcium 169-176 interleukin 6 Homo sapiens 45-49 12101275-8 2002 IL-1-induced inhibition of IL-6 signaling was not mediated by the activation of tyrosine phosphatases or by p38-dependent activation of phospholipase A(2) or cyclooxygenases, which could lead to indirect inhibition via production of prostaglandins. Prostaglandins 233-247 interleukin 6 Homo sapiens 27-31 12016129-9 2002 MAPK inhibitors (SB-203580, PD-98059, and U-0126) significantly reduced the IL-17-induced IL-6 and chemokine secretion. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 28-36 interleukin 6 Homo sapiens 90-94 11920660-4 2002 The results showed that fucan, dextran derivatives, and heparin differentially (1) triggered interleukin-1alpha, tumor necrosis factor alpha, interleukin-6, and interleukin-8 production by monocytes in a dose-dependent manner, (2) modulated cytokine production by LPS-stimulated monocytes, and (3) specifically inhibited the binding of biotinylated LPS to monocyte membranes. Dextrans 31-38 interleukin 6 Homo sapiens 142-155 11920660-4 2002 The results showed that fucan, dextran derivatives, and heparin differentially (1) triggered interleukin-1alpha, tumor necrosis factor alpha, interleukin-6, and interleukin-8 production by monocytes in a dose-dependent manner, (2) modulated cytokine production by LPS-stimulated monocytes, and (3) specifically inhibited the binding of biotinylated LPS to monocyte membranes. Heparin 56-63 interleukin 6 Homo sapiens 142-155 11920666-7 2002 The most toxic metals (V, Mn, Fe, and Ni) were also the only metals found to induce IL-6 secretion on a per cell basis (of the cytokines tested, interleukin 6 (IL-6), interleukin beta 1 (IL-1beta), transforming growth factor beta 1 (TGF-beta1), and tumor necrosis factor alpha (TNF-alpha), only IL-6 was detectable in the culture medium after 48 h for any metal at any concentration). Iron 30-32 interleukin 6 Homo sapiens 84-88 11920666-7 2002 The most toxic metals (V, Mn, Fe, and Ni) were also the only metals found to induce IL-6 secretion on a per cell basis (of the cytokines tested, interleukin 6 (IL-6), interleukin beta 1 (IL-1beta), transforming growth factor beta 1 (TGF-beta1), and tumor necrosis factor alpha (TNF-alpha), only IL-6 was detectable in the culture medium after 48 h for any metal at any concentration). Metals 15-20 interleukin 6 Homo sapiens 84-88 11920666-7 2002 The most toxic metals (V, Mn, Fe, and Ni) were also the only metals found to induce IL-6 secretion on a per cell basis (of the cytokines tested, interleukin 6 (IL-6), interleukin beta 1 (IL-1beta), transforming growth factor beta 1 (TGF-beta1), and tumor necrosis factor alpha (TNF-alpha), only IL-6 was detectable in the culture medium after 48 h for any metal at any concentration). Metals 15-20 interleukin 6 Homo sapiens 160-164 11920666-7 2002 The most toxic metals (V, Mn, Fe, and Ni) were also the only metals found to induce IL-6 secretion on a per cell basis (of the cytokines tested, interleukin 6 (IL-6), interleukin beta 1 (IL-1beta), transforming growth factor beta 1 (TGF-beta1), and tumor necrosis factor alpha (TNF-alpha), only IL-6 was detectable in the culture medium after 48 h for any metal at any concentration). Metals 15-20 interleukin 6 Homo sapiens 160-164 12077742-7 2002 Assessing the results of men and women separately, women showed significantly higher interleukin-6 (IL-6) values after the high-isoflavone soy diet (P =.013) compared to control values. Isoflavones 128-138 interleukin 6 Homo sapiens 85-98 12077742-7 2002 Assessing the results of men and women separately, women showed significantly higher interleukin-6 (IL-6) values after the high-isoflavone soy diet (P =.013) compared to control values. Isoflavones 128-138 interleukin 6 Homo sapiens 100-104 12077742-8 2002 For women, the difference between the high- and low-isoflavone IL-6 values was significant using the unadjusted data (P =.048) but not after adjustment. Isoflavones 52-62 interleukin 6 Homo sapiens 63-67 12077742-10 2002 Thus, high levels of isoflavone intake appear to increase serum concentrations of IL-6 in women. Isoflavones 21-31 interleukin 6 Homo sapiens 82-86 12137744-5 2002 The inhibitors SB203580, PD98059, SN50, cycloheximide and D-ribofuranosylbenzimidazole each reduced the basal and TNFalpha-stimulated secretion of IL-1beta and also reduced IL-6 secretion with the exception of SN50. SN50 34-38 interleukin 6 Homo sapiens 173-177 12006357-4 2002 Infusion of glucose and insulin significantly amplified and/or prolonged the cardiovascular, plasma interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and counterregulatory hormone responses to LPS, whereas the effects on fever, plasma norepinephrine concentrations, and oxygen consumption were unaffected. Glucose 12-19 interleukin 6 Homo sapiens 100-113 12006357-4 2002 Infusion of glucose and insulin significantly amplified and/or prolonged the cardiovascular, plasma interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and counterregulatory hormone responses to LPS, whereas the effects on fever, plasma norepinephrine concentrations, and oxygen consumption were unaffected. Glucose 12-19 interleukin 6 Homo sapiens 115-119 12114260-0 2002 Differential male and female adrenal cortical steroid hormone and cortisol responses to interleukin-6 in humans. Steroids 46-61 interleukin 6 Homo sapiens 88-101 12107724-0 2002 Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-alpha or its receptors. Glucose 9-16 interleukin 6 Homo sapiens 80-93 12114287-8 2002 We found immunoreactivity for the IL-6 receptor on cultured cells and paraffin-embedded sections of adrenal tissues. Paraffin 70-78 interleukin 6 Homo sapiens 34-38 12029003-7 2002 Atorvastatin treatment had a significant main effect of decreasing plasma hs-CRP (-0.87 mg/L; 95% confidence interval, -0.10 to -1.60 mg/L; P <0.01) and IL-6 (-70 pg/L; 10 to -140 pg/L; P <0.01), but this was not seen with fish oil. Atorvastatin 0-12 interleukin 6 Homo sapiens 156-160 12029003-10 2002 CONCLUSIONS: This study shows that visceral obesity is associated with increased plasma hs-CRP and IL-6 and, hence, a low-grade chronic inflammatory state and that treatment with atorvastatin or atorvastatin with fish oil, but not fish oil alone, reverses this abnormality. Atorvastatin 179-191 interleukin 6 Homo sapiens 99-103 12111578-4 2002 Only ofloxacin showed a significant inhibitory influence on the endotoxin-induced IL-6 production of PBMNC. pbmnc 101-106 interleukin 6 Homo sapiens 82-86 12039983-9 2002 In the present experiments, NF-kappaB and AP-1 were involved in the MCP-1-mediated induction of IL-6, as demonstrated by cis element double-stranded (decoy) oligonucleotides (ODN). Oligonucleotides 155-173 interleukin 6 Homo sapiens 96-100 12201223-10 2002 These results led us to the hypothesis that inflammatory cytokines such as IL-6 and IL-1 beta regulate proliferation of breast cancer cells through estrogen production by steroid-catalyzing enzymes in the tissue. Steroids 171-178 interleukin 6 Homo sapiens 75-79 12030972-0 2002 Testosterone stimulates proliferation and inhibits interleukin-6 production of normal and hereditary gingival fibromatosis fibroblasts. Testosterone 0-12 interleukin 6 Homo sapiens 51-64 12044971-3 2002 IL6 upregulated the expression of the neuroprotective acidic fibroblast growth factor (aFGF) and reduced the glutamate-induced cytotoxicity. Glutamic Acid 109-118 interleukin 6 Homo sapiens 0-3 12323121-6 2002 The IL-6 induced aromatase activity results in increased serum estradiol level. Estradiol 63-72 interleukin 6 Homo sapiens 4-8 11872747-7 2002 In contrast, IL-6-induced phosphorylation of 4E-BP1 was inhibited by rapamycin, wortmannin, and dominant negative AKT but ERK inhibitors had no effect, indicating ERK function was dispensable. Sirolimus 69-78 interleukin 6 Homo sapiens 13-17 11872748-7 2002 Moreover, PS-1145 blocks the protective effect of IL-6 against Dex-induced apotosis. Dexamethasone 63-66 interleukin 6 Homo sapiens 50-54 11891214-6 2002 Selective MAP kinase kinase (MEK)1/2 inhibitors, PD98059 and U0126, inhibited, in a dose-dependent manner, ML-1-induced expression of IL-6 and IL-8. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 49-56 interleukin 6 Homo sapiens 134-138 12030972-11 2002 These results show that testosterone coordinates the proliferation and production of IL-6 of normal and HGF fibroblasts. Testosterone 24-36 interleukin 6 Homo sapiens 85-89 12023021-4 2002 By prednisolone or phorbol myristate acetate treatment, EC-SOD levels were correlated negatively with levels of IL-6 and IL-8. Tetradecanoylphorbol Acetate 19-44 interleukin 6 Homo sapiens 112-116 12073659-2 2002 Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulphate (DHEA)--the major androgen products of the adrenal gland--have immunosuppressive effect inhibiting interleukin-6 production and substantially determining acute phase reaction. Dehydroepiandrosterone Sulfate 34-65 interleukin 6 Homo sapiens 165-178 11884403-3 2002 However, the membrane-bound IL-6R was nonfunctional, as significant tyrosine phosphorylation of gp130 did not occur in the presence of IL-6. Tyrosine 68-76 interleukin 6 Homo sapiens 28-32 11884403-4 2002 Phorbol myristate acetate induced a dramatic increase of both IL-6R shedding (i.e. the production of sIL-6R) and IL-6 release in osteoblast cultures, but the cell surface expression of gp130 remained unchanged. Tetradecanoylphorbol Acetate 0-25 interleukin 6 Homo sapiens 62-66 11884403-5 2002 IL-6 complexed with sIL-6R, either exogenously introduced or derived from the nonfunctional cell surface form by shedding, induced rapid tyrosine phosphorylation of gp130. Tyrosine 137-145 interleukin 6 Homo sapiens 0-4 11872747-9 2002 Prevention of IL-6-induced p70 activation and 4E-BP1 phosphorylation by the mammalian target of rapamycin inhibitors rapamycin and CCI-779 resulted in inhibition of IL-6-induced myeloma cell growth. Sirolimus 96-105 interleukin 6 Homo sapiens 14-18 11872747-9 2002 Prevention of IL-6-induced p70 activation and 4E-BP1 phosphorylation by the mammalian target of rapamycin inhibitors rapamycin and CCI-779 resulted in inhibition of IL-6-induced myeloma cell growth. Sirolimus 96-105 interleukin 6 Homo sapiens 165-169 12027072-0 2002 Azelastine is more potent than olopatadine n inhibiting interleukin-6 and tryptase release from human umbilical cord blood-derived cultured mast cells. azelastine 0-10 interleukin 6 Homo sapiens 56-69 12027072-11 2002 CONCLUSIONS: These results indicate that azelastine and olopatadine can inhibit CHMCs activation and release of IL-6, tryptase, and histamine. azelastine 41-51 interleukin 6 Homo sapiens 112-116 12010778-7 2002 8-Bromo cyclic AMP and dibutyryl cyclic AMP, cyclic AMP analogues, mimicked the effects of PGE(2) on IL-6, M-CSF, and VEGF production by OA fibroblasts. Cyclic AMP 8-18 interleukin 6 Homo sapiens 101-105 12066846-7 2002 Nitrostyrene treatment of macrophages, stimulated with IFN gamma and LPS, resulted in a dose dependent differential inhibition in IL12, IL6 and nitrite production, even using doses < 0.5 microg/mL. nitrostyrene 0-12 interleukin 6 Homo sapiens 136-139 12010778-0 2002 Regulation by PGE2 of the production of interleukin-6, macrophage colony stimulating factor, and vascular endothelial growth factor in human synovial fibroblasts. Dinoprostone 14-18 interleukin 6 Homo sapiens 40-53 12010778-2 2002 We examined the effects of endogenous prostaglandin E(2) (PGE(2)) on the production of interleukin-6 (IL-6), macrophage colony stimulating factor (M-CSF), and vascular endothelial growth factor (VEGF) by interleukin-1beta (IL-1beta)-stimulated human synovial fibroblasts. Dinoprostone 38-56 interleukin 6 Homo sapiens 87-100 12036196-9 2002 The frequencies of IL-6 gene genotypes in hemodialysis patients were 16.4% for OO, 52.1% for AO and 31.5% for AA. Oxygen 79-81 interleukin 6 Homo sapiens 19-23 12048901-0 2002 Effects of carvedilol on plasma levels of interleukin-6 and tumor necrosis factor-alpha in nine patients with dilated cardiomyopathy. Carvedilol 11-21 interleukin 6 Homo sapiens 42-55 12048901-3 2002 RESULTS: IL-6 was significantly reduced from 0.80 +/- 0.49 pg/ml before therapy to 0.21 +/- 0.08 pg/ml after carvedilol was increased to 20 mg daily (p < 0.05). Carvedilol 109-119 interleukin 6 Homo sapiens 9-13 12048901-4 2002 Moreover, IL-6 level had already decreased significantly compared to the baseline when the dose of carvedilol had reached 10 mg daily (0.28 +/- 0.12 pg/ml, p < 0.05). Carvedilol 99-109 interleukin 6 Homo sapiens 10-14 11994345-0 2002 Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro. Glucose 80-87 interleukin 6 Homo sapiens 15-19 11959895-8 2002 RESULTS: Levels of IL-6 mRNA and protein increased in all cells treated with follicle-stimulating hormone (FSH), luteinizing hormone (LH), 17beta-estradiol, or estrone but increased only in OVCA cells treated with testosterone and 5alpha-dihydrotestosterone. Estradiol 139-155 interleukin 6 Homo sapiens 19-23 11997833-10 2002 RESULTS: Regarding the peritoneal response, laparotomy versus laparoscopy when performed with CO2 significantly increased PMN and decreased the percentage of macrophages (%MF) up to 48 h. There was a significant increase in interleukin-6, and there was a fourfold increase in MF ROS production. Reactive Oxygen Species 279-282 interleukin 6 Homo sapiens 224-237 12009860-0 2002 Morphological alterations and elevations in tumor necrosis factor-alpha, interleukin (IL)-1alpha, and IL-6 in mixed glia cultures following exposure to trimethyltin: modulation by proinflammatory cytokine recombinant proteins and neutralizing antibodies. trimethyltin 152-164 interleukin 6 Homo sapiens 102-106 11959895-8 2002 RESULTS: Levels of IL-6 mRNA and protein increased in all cells treated with follicle-stimulating hormone (FSH), luteinizing hormone (LH), 17beta-estradiol, or estrone but increased only in OVCA cells treated with testosterone and 5alpha-dihydrotestosterone. Testosterone 214-226 interleukin 6 Homo sapiens 19-23 11788581-4 2002 Using high affinity oligosaccharide ligands, it is demonstrated that this lectin activity is responsible for the early dephosphorylation of tyrosine residues found on specific proteins induced by interleukin 6 in human resting lymphocytes. Tyrosine 140-148 interleukin 6 Homo sapiens 196-209 11971193-2 2002 We show here that mutated diphtheria toxin, a specific inhibitor of heparin-binding epidermal growth factor-like growth factor (HB-EGF), blocked the IL-6-induced growth of two myeloma cell lines (XG-1 and XG-14) and did not significantly affect that of two other cell lines (XG-6 and XG-13). Heparin 68-75 interleukin 6 Homo sapiens 149-153 11788581-8 2002 Docking experiments of these conformers suggest that the carbohydrate recognition domain of IL-6 is localized in the domain previously identified as site 3 of IL-6 (Somers, W., Stahl, M., and Seehra, J. S. (1997) EMBO J. Carbohydrates 57-69 interleukin 6 Homo sapiens 92-96 11788581-8 2002 Docking experiments of these conformers suggest that the carbohydrate recognition domain of IL-6 is localized in the domain previously identified as site 3 of IL-6 (Somers, W., Stahl, M., and Seehra, J. S. (1997) EMBO J. Carbohydrates 57-69 interleukin 6 Homo sapiens 159-163 11923038-10 2002 There was a relationship between changes in serum triglycerides and changes in TNF-alpha (r = 0.39, p < 0.01), IL-6 (r = 0.28, p < 0.05) and VCAM-1 (r = 0.25, p < 0.05), and between changes in plasma glucose and changes in IL-6 (r = 0.36, p < 0.01) and ICAM-1 (r = 0.31, p < 0.02). Triglycerides 50-63 interleukin 6 Homo sapiens 114-118 11815625-5 2002 Upon activation of signaling by IL-6 or orthovanadate the respective Tyr-phosphorylated STAT species were now also observed in the membrane raft fraction but in a form deficient in DNA binding. Tyrosine 69-72 interleukin 6 Homo sapiens 32-36 11815625-7 2002 Methyl-beta-cyclodextrin, which sequesters cholesterol and disrupts plasma membrane rafts, markedly inhibited IL-6- and IFN-gamma-induced STAT signaling. methyl-beta-cyclodextrin 0-24 interleukin 6 Homo sapiens 110-142 11815625-7 2002 Methyl-beta-cyclodextrin, which sequesters cholesterol and disrupts plasma membrane rafts, markedly inhibited IL-6- and IFN-gamma-induced STAT signaling. Cholesterol 43-54 interleukin 6 Homo sapiens 110-142 11923038-10 2002 There was a relationship between changes in serum triglycerides and changes in TNF-alpha (r = 0.39, p < 0.01), IL-6 (r = 0.28, p < 0.05) and VCAM-1 (r = 0.25, p < 0.05), and between changes in plasma glucose and changes in IL-6 (r = 0.36, p < 0.01) and ICAM-1 (r = 0.31, p < 0.02). Triglycerides 50-63 interleukin 6 Homo sapiens 232-236 11950692-9 2002 We conclude that ROS signals originating from the mitochondrial ET chain trigger the increase in NF-kappaB activation, the transcriptional activation of IL-6, the secretion of IL-6 into the cell culture media, and the increases in endothelial permeability observed during hypoxia. Reactive Oxygen Species 17-20 interleukin 6 Homo sapiens 153-157 11919083-1 2002 Recent studies have demonstrated that tumor necrosis factor (TNF)-alpha stimulates the secretion of interleukin (IL)-6 and regulated on activation, normal T cells expressed and secreted (RANTES) from airway smooth muscle (ASM) cells, with the induction of each molecule being differentially regulated (IL-6 increased, RANTES inhibited) by cyclic adenosine monophosphate (cAMP)-elevating agents. Cyclic AMP 339-369 interleukin 6 Homo sapiens 100-118 11919083-1 2002 Recent studies have demonstrated that tumor necrosis factor (TNF)-alpha stimulates the secretion of interleukin (IL)-6 and regulated on activation, normal T cells expressed and secreted (RANTES) from airway smooth muscle (ASM) cells, with the induction of each molecule being differentially regulated (IL-6 increased, RANTES inhibited) by cyclic adenosine monophosphate (cAMP)-elevating agents. Cyclic AMP 371-375 interleukin 6 Homo sapiens 100-118 11919083-4 2002 TNF-alpha-induced IL-6 secretion was only partially inhibited by dexamethasone, yet TNF-alpha-induced RANTES secretion was abolished. Dexamethasone 65-78 interleukin 6 Homo sapiens 18-22 11950692-9 2002 We conclude that ROS signals originating from the mitochondrial ET chain trigger the increase in NF-kappaB activation, the transcriptional activation of IL-6, the secretion of IL-6 into the cell culture media, and the increases in endothelial permeability observed during hypoxia. Reactive Oxygen Species 17-20 interleukin 6 Homo sapiens 176-180 11948053-7 2002 There was a significant positive correlation between IL-6 production in the lung and both PVR (r = 0.43; p = 0.001) and cGMP production in the lung (r = 0.498; p < 0.0001). Cyclic GMP 120-124 interleukin 6 Homo sapiens 53-57 12144121-6 2002 RESULTS: TNF-alpha and IL-6 serum concentrations significantly decreased after steroid therapy administration. Steroids 79-86 interleukin 6 Homo sapiens 23-27 12144121-10 2002 Symptom regression following steroid therapy administration went along with significant decrease of cytokines levels, confirming that TNF-alpha and IL-6 play a role in the pathogenesis of this reaction. Steroids 29-36 interleukin 6 Homo sapiens 148-152 11961304-0 2002 Effects of high glucose on interleukin-6 production in human mesangial cells. Glucose 16-23 interleukin 6 Homo sapiens 27-40 11961304-7 2002 Incubation of mesangial cells with high glucose (450 mg/dL) reduced the ratio of PCR products for IL-6 to beta-actin on densitometric results, while AGII (10(-7)M) increased it. Glucose 40-47 interleukin 6 Homo sapiens 98-102 11961304-8 2002 The IL-6 secretion in the supernatant was also increased by AGII and decreased by high glucose. Glucose 87-94 interleukin 6 Homo sapiens 4-8 11961304-9 2002 The IL-6 mRNA expression and IL-6 secretion in combination of high glucose and AGII were higher than those in high glucose and similar with those in control media. Glucose 67-74 interleukin 6 Homo sapiens 4-8 11961304-9 2002 The IL-6 mRNA expression and IL-6 secretion in combination of high glucose and AGII were higher than those in high glucose and similar with those in control media. Glucose 67-74 interleukin 6 Homo sapiens 29-33 11961304-9 2002 The IL-6 mRNA expression and IL-6 secretion in combination of high glucose and AGII were higher than those in high glucose and similar with those in control media. Glucose 115-122 interleukin 6 Homo sapiens 4-8 11961304-12 2002 The IL-6 production of mesangial cells in diabetic milieu may be complicated and depend on the local effects of high glucose and/or AGII. Glucose 117-124 interleukin 6 Homo sapiens 4-8 12027404-0 2002 Overexpression of IL-6 but not IL-8 increases paclitaxel resistance of U-2OS human osteosarcoma cells. Paclitaxel 46-56 interleukin 6 Homo sapiens 18-22 11950021-10 2002 ACECLO, DICLO, INDO, NIM significantly inhibited basal and IL-1beta stimulated IL-6 production; CELE and IBUP only inhibited IL-1beta stimulated IL-6 production; and ROFE and PIROX had no significant effects. Ibuprofen 105-109 interleukin 6 Homo sapiens 145-149 12133393-0 2002 [Inhibition of IL-6 antisense oligonucleotide on IL-6 expression by human retinal pigment epithelium in vitro]. Oligonucleotides 30-45 interleukin 6 Homo sapiens 15-19 12133393-0 2002 [Inhibition of IL-6 antisense oligonucleotide on IL-6 expression by human retinal pigment epithelium in vitro]. Oligonucleotides 30-45 interleukin 6 Homo sapiens 49-53 12133393-1 2002 OBJECTIVE: To investigate the inhibition of IL-6 antisense oligonucleotide (ASON) on IL-6 expression by retinal pigment epithelium (RPE) cells on the basis of previous study. Oligonucleotides 59-74 interleukin 6 Homo sapiens 44-48 12133393-1 2002 OBJECTIVE: To investigate the inhibition of IL-6 antisense oligonucleotide (ASON) on IL-6 expression by retinal pigment epithelium (RPE) cells on the basis of previous study. Oligonucleotides 59-74 interleukin 6 Homo sapiens 85-89 12027404-13 2002 In summary, while both IL-6 and IL-8 are overexpressed in paclitaxel resistant cell lines, only IL-6 has the potential to contribute directly to paclitaxel and doxorubicin resistance in U-2OS. Paclitaxel 58-68 interleukin 6 Homo sapiens 23-27 12027404-13 2002 In summary, while both IL-6 and IL-8 are overexpressed in paclitaxel resistant cell lines, only IL-6 has the potential to contribute directly to paclitaxel and doxorubicin resistance in U-2OS. Paclitaxel 145-155 interleukin 6 Homo sapiens 96-100 11960349-0 2002 Downregulation of IL-6-induced STAT3 tyrosine phosphorylation by TGF-beta1 is mediated by caspase-dependent and -independent processes. Tyrosine 37-45 interleukin 6 Homo sapiens 18-22 11960349-1 2002 To explore the possible cross-talk between the IL-6 and TGF-beta1 pathways in AML blast cells, the effect of TGF-beta1 pretreatment on IL-6-induced STAT3 tyrosine phosphorylation was studied. Tyrosine 154-162 interleukin 6 Homo sapiens 135-139 11960349-3 2002 The reduced IL-6-mediated STAT3 tyrosine phosphorylation after pre-treatment with TGF-beta1 was associated with apoptosis and coincided with the degradation of certain cellular proteins, including JAK1 and -2 and Tyk2, without affecting the ERK expression and phosphorylation. Tyrosine 32-40 interleukin 6 Homo sapiens 12-16 11960349-4 2002 Furthermore, treatment of AML blasts with the cytostatic agent VP16, as an alternative way to induce apoptosis, resulted in a similar degree of degradation of JAK kinases and concomitant reduction of IL-6-mediated STAT3 tyrosine phosphorylation. Tyrosine 220-228 interleukin 6 Homo sapiens 200-204 11923478-10 2002 Taken together, our results indicate that IL-6-inducible expression of the hAGT promoter is mediated by physical association of the COOH terminus of STAT3 with p300/CBP, the recruitment of which targets histone acetylation and results in chromatin remodeling. Carbonic Acid 132-136 interleukin 6 Homo sapiens 42-46 11788590-5 2002 Interleukin 6 and interleukin 11, known to activate STAT3 synergistically, stimulated the SP-B promoter activity with retinoic acid, which is at least partially mediated through interactions between STAT3 and retinoid nuclear receptor enhanceosome proteins in pulmonary epithelial cells. Tretinoin 118-131 interleukin 6 Homo sapiens 0-13 12027404-13 2002 In summary, while both IL-6 and IL-8 are overexpressed in paclitaxel resistant cell lines, only IL-6 has the potential to contribute directly to paclitaxel and doxorubicin resistance in U-2OS. Doxorubicin 160-171 interleukin 6 Homo sapiens 96-100 12027404-6 2002 MTT cytotoxicity with IL-6 transfected cells demonstrates a five-fold increase in resistance to paclitaxel and a four-fold increase in resistance to doxorubicin as compared to U-2OS. Paclitaxel 96-106 interleukin 6 Homo sapiens 22-26 12027404-6 2002 MTT cytotoxicity with IL-6 transfected cells demonstrates a five-fold increase in resistance to paclitaxel and a four-fold increase in resistance to doxorubicin as compared to U-2OS. Doxorubicin 149-160 interleukin 6 Homo sapiens 22-26 12027404-11 2002 Treatment of IL-6 transfected cells with paclitaxel, compared with drug-sensitive parental U-2OS, shows U-2OS(IL-6) are significantly more resistant to apoptosis induced by paclitaxel and exhibit decreased proteolytic activation of caspase-3. Paclitaxel 41-51 interleukin 6 Homo sapiens 13-17 12027404-11 2002 Treatment of IL-6 transfected cells with paclitaxel, compared with drug-sensitive parental U-2OS, shows U-2OS(IL-6) are significantly more resistant to apoptosis induced by paclitaxel and exhibit decreased proteolytic activation of caspase-3. Paclitaxel 41-51 interleukin 6 Homo sapiens 110-114 12027404-11 2002 Treatment of IL-6 transfected cells with paclitaxel, compared with drug-sensitive parental U-2OS, shows U-2OS(IL-6) are significantly more resistant to apoptosis induced by paclitaxel and exhibit decreased proteolytic activation of caspase-3. Paclitaxel 173-183 interleukin 6 Homo sapiens 13-17 12027404-11 2002 Treatment of IL-6 transfected cells with paclitaxel, compared with drug-sensitive parental U-2OS, shows U-2OS(IL-6) are significantly more resistant to apoptosis induced by paclitaxel and exhibit decreased proteolytic activation of caspase-3. Paclitaxel 173-183 interleukin 6 Homo sapiens 110-114 12017180-2 2002 To gain further insight into the molecular pathogenesis of pulpitis, we investigated the effects of IL-1alpha or TNF-alpha and PGE2, either alone or in combination on IL-6 and cyclooxygenase (COX)-2 messenger RNA (mRNA) production in cultured human dental pulp (HDP) fibroblasts. Dinoprostone 127-131 interleukin 6 Homo sapiens 167-171 11920401-0 2002 Inadequately low serum levels of steroid hormones in relation to interleukin-6 and tumor necrosis factor in untreated patients with early rheumatoid arthritis and reactive arthritis. Steroids 33-49 interleukin 6 Homo sapiens 65-78 11886382-1 2002 Recently, it was disclosed that all-trans retinoic acid (ATRA) inhibits myeloma cell growth by downregulating the interleukin 6 (IL-6)/IL-6 receptor (IL-6R) auto/paracrine loop, and upregulating p21/Cip1 cyclin-dependent kinase inhibitor (CDK-I), thereby inducing apoptosis with a decrease in Bcl-2 protein expression. Tretinoin 42-55 interleukin 6 Homo sapiens 114-127 11886382-1 2002 Recently, it was disclosed that all-trans retinoic acid (ATRA) inhibits myeloma cell growth by downregulating the interleukin 6 (IL-6)/IL-6 receptor (IL-6R) auto/paracrine loop, and upregulating p21/Cip1 cyclin-dependent kinase inhibitor (CDK-I), thereby inducing apoptosis with a decrease in Bcl-2 protein expression. Tretinoin 42-55 interleukin 6 Homo sapiens 129-133 11886382-1 2002 Recently, it was disclosed that all-trans retinoic acid (ATRA) inhibits myeloma cell growth by downregulating the interleukin 6 (IL-6)/IL-6 receptor (IL-6R) auto/paracrine loop, and upregulating p21/Cip1 cyclin-dependent kinase inhibitor (CDK-I), thereby inducing apoptosis with a decrease in Bcl-2 protein expression. Tretinoin 42-55 interleukin 6 Homo sapiens 135-139 11886382-1 2002 Recently, it was disclosed that all-trans retinoic acid (ATRA) inhibits myeloma cell growth by downregulating the interleukin 6 (IL-6)/IL-6 receptor (IL-6R) auto/paracrine loop, and upregulating p21/Cip1 cyclin-dependent kinase inhibitor (CDK-I), thereby inducing apoptosis with a decrease in Bcl-2 protein expression. Tretinoin 57-61 interleukin 6 Homo sapiens 114-127 11886382-1 2002 Recently, it was disclosed that all-trans retinoic acid (ATRA) inhibits myeloma cell growth by downregulating the interleukin 6 (IL-6)/IL-6 receptor (IL-6R) auto/paracrine loop, and upregulating p21/Cip1 cyclin-dependent kinase inhibitor (CDK-I), thereby inducing apoptosis with a decrease in Bcl-2 protein expression. Tretinoin 57-61 interleukin 6 Homo sapiens 129-133 11886382-1 2002 Recently, it was disclosed that all-trans retinoic acid (ATRA) inhibits myeloma cell growth by downregulating the interleukin 6 (IL-6)/IL-6 receptor (IL-6R) auto/paracrine loop, and upregulating p21/Cip1 cyclin-dependent kinase inhibitor (CDK-I), thereby inducing apoptosis with a decrease in Bcl-2 protein expression. Tretinoin 57-61 interleukin 6 Homo sapiens 135-139 12017180-4 2002 Simultaneous addition of IL-1alpha and PGE2 or TNF-alpha and PGE2 to the cultures significantly reduced the cytokine-induced IL-6 mRNA synthesis ranging from 45% to 65%. Dinoprostone 39-43 interleukin 6 Homo sapiens 125-129 12017180-4 2002 Simultaneous addition of IL-1alpha and PGE2 or TNF-alpha and PGE2 to the cultures significantly reduced the cytokine-induced IL-6 mRNA synthesis ranging from 45% to 65%. Dinoprostone 61-65 interleukin 6 Homo sapiens 125-129 12017180-9 2002 Furthermore, expression of IL-6 and COX-2 genes in this cell seems to be differentially regulated by cytokines through prostaglandin-dependent and -independent pathways. Prostaglandins 119-132 interleukin 6 Homo sapiens 27-31 11857082-7 2002 In addition, although the level of AKT activation can regulate sensitivity to dexamethasone-induced apoptosis, additional cytokine-induced AKT-independent pathways can mediate IL-6 protection against dexamethasone. Dexamethasone 200-213 interleukin 6 Homo sapiens 176-180 11942326-4 2002 Here we demonstrate that cisplatin (CDDP) and etoposide (VP-16) induce nuclear translocation of NF-kappaB in prostate cancer cell lines, followed by secretion of IL-6. Cisplatin 25-34 interleukin 6 Homo sapiens 162-166 11942326-4 2002 Here we demonstrate that cisplatin (CDDP) and etoposide (VP-16) induce nuclear translocation of NF-kappaB in prostate cancer cell lines, followed by secretion of IL-6. Cisplatin 36-40 interleukin 6 Homo sapiens 162-166 11849447-8 2002 RESULTS: IL-6 induced tyrosine phosphorylation and increased the DNA binding activity of STAT3 and, to a lesser extent, STAT1 in all cell lines except for Caki-1, which did not express the IL-6 receptor subunit gp130. Tyrosine 22-30 interleukin 6 Homo sapiens 9-13 11849447-10 2002 IL-6-induced STAT3 tyrosine phosphorylation and DNA binding activity was inhibited by treatment with Jak specific inhibitor AG 490; however, it was not affected by the MEK1 inhibitor PD 98059. Tyrosine 19-27 interleukin 6 Homo sapiens 0-4 11859294-10 2002 While searching for the possible cause of inhibited IL-6/Stat3 signaling, we found that IL-6 receptor (IL-6R & gp130) was preserved, that nuclear Stat3 protein content was lowered, and that IL-6/Stat3 pathway inhibitors (SOCS-1, PIAS3) were induced during the pre-replicative Go-G1 period. Adenosine Monophosphate 110-113 interleukin 6 Homo sapiens 52-56 11854119-5 2002 Concentrations of TNF-alpha and IL-6 were related (P<0.01) to visceral obesity, as well as to adhesin levels and responses to L-arginine. Arginine 129-139 interleukin 6 Homo sapiens 32-36 11845881-8 2002 In group 1, preoperative IL-6 levels inversely correlated with preoperative oxygen saturation (Spearman correlation coefficient, -0.74, p < 0.02). Oxygen 76-82 interleukin 6 Homo sapiens 25-29 11845881-10 2002 In all patients, postoperative IL-6 levels were positively correlated with duration of inotropic support and serum creatinine value and inversely correlated with oxygenation index and diuresis. Creatinine 115-125 interleukin 6 Homo sapiens 31-35 11842936-2 2002 In the present study, we investigated whether PGE2 regulated interleukin (IL)-6 production in human gingival fibroblasts (HGF) stimulated with IL-1beta and if so, which subtype(s) of PGE2 receptors were involved. Dinoprostone 46-50 interleukin 6 Homo sapiens 61-79 11842936-4 2002 Exogenous PGE2 suppressed the IL-1beta-induced IL-6 production. Dinoprostone 10-14 interleukin 6 Homo sapiens 47-51 11842936-8 2002 Based on these data, we suggest that PGE2 can up- or downregulate IL-1beta-induced IL-6 production via EP1 receptors or via EP2/EP4 receptors in HGF, respectively. Dinoprostone 37-41 interleukin 6 Homo sapiens 83-87 12479056-1 2002 BACKGROUND & OBJECTIVE: IL-6 can protect myeloma cells from apoptosis induced by various stimuli. Adenosine Monophosphate 12-15 interleukin 6 Homo sapiens 28-32 11830554-7 2002 Electrophoretic mobility shift assays showed decreased binding of CAAT enhancer binding protein, cyclic AMP responsive element binding protein, +/- nuclear factor-kappaB transcription factors to the IL-6 promoter in various RCC cell lines transfected with wt p53 (P < 0.05) but not in those transfected with mut p53. Cyclic AMP 97-107 interleukin 6 Homo sapiens 199-203 11818251-0 2002 Inhibition of growth of human hepatoma cells by dual-function antisense IL-6 oligonucleotides. Oligonucleotides 77-93 interleukin 6 Homo sapiens 72-76 12022439-2 2002 Chlorogenic acid, a plant polyphenol, inhibited SE-induced T-cell proliferation (by 98%) and production of interleukin 1beta, tumor necrosis factor, interleukin 6, interferon gamma, monocyte chemotactic protein I (MCP-l), macrophage inflammatory protein (MIP)-lalpha, and MIP-lbeta by human peripheral blood mononuclear cells. Chlorogenic Acid 0-16 interleukin 6 Homo sapiens 149-162 12022445-7 2002 YH-Tang significantly inhibited interleukin (IL)-1, IL-4, IL-6 and tumor necrosis factor-alpha (TNF-alpha) secretion in astrocytes stimulated with SP and LPS, but did not inhibit interferon-y (IFN-gamma) and IL-2 secretion significantly. yh-tang 0-7 interleukin 6 Homo sapiens 58-62 11834456-2 2002 There is, however, controversy about the nature of the IL-6 secreted by human cells and its regulation by 17beta-oestradiol. Estradiol 106-123 interleukin 6 Homo sapiens 55-59 11834456-7 2002 The effect of 17beta-oestradiol on spontaneous IL-6 production by the PBMC of postmenopausal women was also studied in vitro and in vivo. Estradiol 14-31 interleukin 6 Homo sapiens 47-51 11834456-12 2002 Women with IL-6 gene expression in the non-stimulated PBMC had significantly lower serum levels of 17beta-oestradiol compared with those where the IL-6 gene was not expressed in the PBMC. Estradiol 99-116 interleukin 6 Homo sapiens 11-15 11834456-13 2002 Our in vitro experiments showed that 17beta-oestradiol at concentrations of 10(-9) M and 10(-10) M decreased spontaneous IL-6 production by the PBMC of postmenopausal women. Estradiol 37-54 interleukin 6 Homo sapiens 121-125 11834456-14 2002 In vivo treatment with 17beta-oestradiol transdermally also significantly decreased spontaneous IL-6 production by the PBMC of postmenopausal women after 12 months of the therapy. Estradiol 23-40 interleukin 6 Homo sapiens 96-100 11805217-9 2002 Simultaneous inhibition of PDE5, 6, and 9 (zaprinast), purported to specifically elevate intracellular cGMP, reduced, in a dose-independent manner, IL-6 and TNF-alpha biosynthesis. Cyclic GMP 103-107 interleukin 6 Homo sapiens 148-152 11859294-10 2002 While searching for the possible cause of inhibited IL-6/Stat3 signaling, we found that IL-6 receptor (IL-6R & gp130) was preserved, that nuclear Stat3 protein content was lowered, and that IL-6/Stat3 pathway inhibitors (SOCS-1, PIAS3) were induced during the pre-replicative Go-G1 period. Adenosine Monophosphate 110-113 interleukin 6 Homo sapiens 88-92 11859294-10 2002 While searching for the possible cause of inhibited IL-6/Stat3 signaling, we found that IL-6 receptor (IL-6R & gp130) was preserved, that nuclear Stat3 protein content was lowered, and that IL-6/Stat3 pathway inhibitors (SOCS-1, PIAS3) were induced during the pre-replicative Go-G1 period. Adenosine Monophosphate 110-113 interleukin 6 Homo sapiens 88-92 12498381-5 2002 The primary function of the additional IL-6 may be to regulate the supply of carbohydrate as muscle reserves of glycogen become depleted. Carbohydrates 77-89 interleukin 6 Homo sapiens 39-43 11915555-2 2002 Fever mediators are mainly derived from the host cells and are pyrogenous cytokines such as interleukin-1, tumour necrosis factor alpha, interleukin-6 or interferons which act at the hypothalamus level via prostaglandin E2. Dinoprostone 206-222 interleukin 6 Homo sapiens 137-150 11779161-0 2002 Prostaglandin E(2) stimulates prostatic intraepithelial neoplasia cell growth through activation of the interleukin-6/GP130/STAT-3 signaling pathway. Dinoprostone 0-18 interleukin 6 Homo sapiens 104-117 11791174-4 2002 Expression of both anti-apoptotic (such as Bcl-2 and Bcl-x(L)) and proapoptotic (such as Bax) proteins is markedly elevated in the liver of human ALD and chronically ethanol-fed IL-6 (+/+) mice. Ethanol 166-173 interleukin 6 Homo sapiens 178-182 11779161-9 2002 Finally, PGE(2)-stimulated PIN cell growth was abrogated by the addition of IL-6 neutralizing antibodies. Dinoprostone 9-15 interleukin 6 Homo sapiens 76-80 11849244-1 2002 OBJECTIVE: Current thinking is that amiodarone-induced thyrotoxicosis (AIT) might be either iodine-induced thyrotoxicosis in latent hyperthyroidism (Type 1) or destructive thyroiditis (Type 2), and also that colour-flow Doppler sonography (CFDS) of the thyroid and serum interleukin 6 (IL-6) are tools that can classify AIT and direct treatment. Amiodarone 36-46 interleukin 6 Homo sapiens 271-284 11849244-1 2002 OBJECTIVE: Current thinking is that amiodarone-induced thyrotoxicosis (AIT) might be either iodine-induced thyrotoxicosis in latent hyperthyroidism (Type 1) or destructive thyroiditis (Type 2), and also that colour-flow Doppler sonography (CFDS) of the thyroid and serum interleukin 6 (IL-6) are tools that can classify AIT and direct treatment. Amiodarone 36-46 interleukin 6 Homo sapiens 286-290 12424420-3 2002 STUDY DESIGN: The IL-1beta-induced IL-6/IL-8 release of HPMC from healthy donors and from patients with end-stage renal disease (ESRD) were measured before the start of chronic peritoneal dialysis (PD) and during PD therapy. hydroxypropylmethylcellulose-lactose matrix 56-60 interleukin 6 Homo sapiens 35-39 11885806-2 2002 Our study was designed to determine whether heat shock and drugs like cisplatin, etoposide and quercetin have an effect on the expression of heat shock protein 27 in tumour cells such as: HeLa (cervical cancer), Hep-2 (larynx cancer), A549 (lung cancer) and also in normal human skin fibroblasts (HSF) cultured in two-dimensional (2D) and three-dimensional (3D) conditions. Cisplatin 70-79 interleukin 6 Homo sapiens 297-300 11799073-9 2002 Incubation of VSMCs with the antioxidant N-acetylcysteine suppressed GSA-elicited mRNA induction of MCP-1 and IL-6. Acetylcysteine 41-57 interleukin 6 Homo sapiens 110-114 11916128-7 2002 The histamine-induced up-regulation of IL-6 and IL-8 production, however, was completely abrogated by a combination of pyrilamine and cimetidine. Histamine 4-13 interleukin 6 Homo sapiens 39-43 11916128-9 2002 Interestingly, IFN-gamma and IL-4 both significantly augmented the histamine-induced IL-6 production. Histamine 67-76 interleukin 6 Homo sapiens 85-89 11916128-11 2002 These results suggest that the histamine-induced IL-6 production and IL-8 production are differentially regulated by IFN-gamma and IL-4. Histamine 31-40 interleukin 6 Homo sapiens 49-53 11782767-10 2002 RESULTS: As expected, dexamethasone pretreatment attenuated interleukin 6 release and the clinical systemic inflammatory response after bypass. Dexamethasone 22-35 interleukin 6 Homo sapiens 60-73 11916128-0 2002 Histamine-induced IL-6 and IL-8 production are differentially modulated by IFN-gamma and IL-4 in human keratinocytes. Histamine 0-9 interleukin 6 Homo sapiens 18-22 11916128-3 2002 We therefore examined the capacity of histamine to modulate the production of interleukin (IL)-6 and IL-8 by keratinocytes. Histamine 38-47 interleukin 6 Homo sapiens 78-96 11916128-4 2002 We found that histamine significantly augmented the production of IL-6 and IL-8 in a dose- and time-dependent manner. Histamine 14-23 interleukin 6 Homo sapiens 66-70 11824970-11 2002 IL-6 and IL-10 levels were significantly inhibited by Dex 10 M in both the control and RA groups. Dexamethasone 54-57 interleukin 6 Homo sapiens 0-4 12476615-2 2002 Our study was designed to determine whether heat shock and drugs like cisplatin, etoposide and quercetin influence the expression of heat shock protein 72 in tumour cells: HeLa (cervical cancer), Hep-2 (larynx cancer), A549 (lung cancer) and normal human skin fibroblasts (HSF). Cisplatin 70-79 interleukin 6 Homo sapiens 273-276 11751424-4 2001 This study demonstrates that interleukin-6 (IL-6) effectively protects gastric cancer cells from the apoptosis induced by hydrogen peroxide (H(2)O(2)). Hydrogen Peroxide 122-139 interleukin 6 Homo sapiens 29-42 11739196-3 2001 EMSA demonstrated a significant increase in LIL-STAT binding to the LILRE oligonucleotides after interferon gamma (IFN-gamma) and IL-6 stimulation of THP-1 cells. Oligonucleotides 74-90 interleukin 6 Homo sapiens 130-134 11814313-9 2001 Each steroid also significantly inhibited IL-6 secretion by KM101 cells. Steroids 5-12 interleukin 6 Homo sapiens 42-46 11766169-6 2001 Four other 8-ketotrichothecenes, fusarenon X, nivalenol, 3-acetyl DON, and 15-acetyl DON, were also capable of upregulating or suppressing TNF-alpha, IL-6, and IL-8 production at concentrations similar to that of DON. 8-ketotrichothecenes 11-31 interleukin 6 Homo sapiens 150-154 11766169-6 2001 Four other 8-ketotrichothecenes, fusarenon X, nivalenol, 3-acetyl DON, and 15-acetyl DON, were also capable of upregulating or suppressing TNF-alpha, IL-6, and IL-8 production at concentrations similar to that of DON. fusarenon-X 33-44 interleukin 6 Homo sapiens 150-154 11739520-4 2001 IL-1beta and TNF-alpha, and to a lesser degree IL-6, accelerate facilitated glucose transport as measured by [(3)H]2-deoxyglucose uptake. Glucose 76-83 interleukin 6 Homo sapiens 47-51 11814313-0 2001 Adrenal and gonadal steroids inhibit IL-6 secretion by human marrow cells. Steroids 20-28 interleukin 6 Homo sapiens 37-41 11814313-1 2001 Adrenal and gonadal steroids have protective effects on the skeleton that may be conferred partly by their ability to inhibit bone resorptive cytokines such as interleukin 6 (IL-6). Steroids 20-28 interleukin 6 Homo sapiens 160-173 11814313-1 2001 Adrenal and gonadal steroids have protective effects on the skeleton that may be conferred partly by their ability to inhibit bone resorptive cytokines such as interleukin 6 (IL-6). Steroids 20-28 interleukin 6 Homo sapiens 175-179 11814313-2 2001 We tested the hypothesis that IL-6 secretion by human marrow cells and a line of marrow stromal cells (KM101) is inhibited by dehydroepiandrosterone (DHEA), dihydrotestosterone (DHT) and 17beta-oestradiol (E(2)). Estradiol 187-204 interleukin 6 Homo sapiens 30-34 11814313-3 2001 We also examined whether the estrogen status of the donor influenced the steroids" effects on IL-6 secretion. Steroids 73-81 interleukin 6 Homo sapiens 94-98 11751424-4 2001 This study demonstrates that interleukin-6 (IL-6) effectively protects gastric cancer cells from the apoptosis induced by hydrogen peroxide (H(2)O(2)). Hydrogen Peroxide 122-139 interleukin 6 Homo sapiens 44-48 11751424-5 2001 The cell death signaling JNK pathway elicited by H(2)O(2) is also inhibited by IL-6. Hydrogen Peroxide 49-57 interleukin 6 Homo sapiens 79-83 11751424-13 2001 Results in this study provide a novel mechanism by which up-regulation of the Mcl-1 protein by IL-6 may enhance the susceptibility to H(2)O(2)-induced oxidative DNA lesions by overriding apoptosis. Hydrogen Peroxide 134-142 interleukin 6 Homo sapiens 95-99 11768272-7 2001 The single exception was the chain-breaking antioxidant butylated hydroxyanisole (BHA), which markedly inhibited IL-6 and IL-8 secretion, but had no effect on NF-kappaB activation. Butylated Hydroxyanisole 56-80 interleukin 6 Homo sapiens 113-117 11768272-7 2001 The single exception was the chain-breaking antioxidant butylated hydroxyanisole (BHA), which markedly inhibited IL-6 and IL-8 secretion, but had no effect on NF-kappaB activation. Butylated Hydroxyanisole 82-85 interleukin 6 Homo sapiens 113-117 11739606-6 2001 PGE2-induced IL-6 synthesis was inhibited by specific inhibitors of p38 MAPK (SB202190) and PKC (GF203190X). Dinoprostone 0-4 interleukin 6 Homo sapiens 13-17 11687509-8 2001 These findings also support the hypothesis that IL-6 may be produced by contracting myofibers when glycogen levels become critically low as a means of signaling the liver to increase glucose production. Glucose 183-190 interleukin 6 Homo sapiens 48-52 11739453-8 2001 Plasma IL-6 levels at 3 h were increased by clenbuterol (P = 0.02) and CL316243 (P = 0.02) but not dobutamine (P = 0.51), compared with placebo. disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate 71-79 interleukin 6 Homo sapiens 7-11 11739606-0 2001 Mechanisms of prostaglandin E2-induced interleukin-6 release in astrocytes: possible involvement of EP4-like receptors, p38 mitogen-activated protein kinase and protein kinase C. The expression of cyclooxygenase-2 (COX-2) and the synthesis of prostaglandin E2 (PGE2) as well as of cytokines such as interleukin-6 (IL-6) have all been suggested to propagate neuropathology in different brain disorders such as HIV-dementia, prion diseases, stroke and Alzheimer"s disease. Dinoprostone 14-30 interleukin 6 Homo sapiens 39-52 11739606-1 2001 In this report, we show that PGE2-stimulated IL-6 release in U373 MG human astroglioma cells and primary rat astrocytes. Dinoprostone 29-33 interleukin 6 Homo sapiens 45-49 11739606-7 2001 Although, up to now, EP receptors have only rarely been linked to p38 MAPK or PKC activation, these results suggest that PGE2 induces IL-6 via an EP4-like receptor by the activation of PKC and p38 MAPK via an EP4-like receptor independently of cAMP. Dinoprostone 121-125 interleukin 6 Homo sapiens 134-138 11739606-7 2001 Although, up to now, EP receptors have only rarely been linked to p38 MAPK or PKC activation, these results suggest that PGE2 induces IL-6 via an EP4-like receptor by the activation of PKC and p38 MAPK via an EP4-like receptor independently of cAMP. Cyclic AMP 244-248 interleukin 6 Homo sapiens 134-138 11768200-7 2001 IL-6 was also able to revert the inhibitory effect of dexamethasone (1 microM) on GR in both cell lines. Dexamethasone 54-67 interleukin 6 Homo sapiens 0-4 11740818-7 2001 PS-341 adds to the anti-MM activity of dexamethasone and overcomes IL-6-mediated protection against dexamethasone-induced apoptosis. Dexamethasone 100-113 interleukin 6 Homo sapiens 67-71 11694151-11 2001 Those taking dalteparin with elevated IL-6 levels experienced lower 6-month mortality than those who did not take dalteparin (3.5% absolute reduction; P =.08). Heparin 13-23 interleukin 6 Homo sapiens 38-42 11701462-0 2001 Thrombin induces interleukin-6 expression through the cAMP response element in vascular smooth muscle cells. Cyclic AMP 54-58 interleukin 6 Homo sapiens 17-30 11701462-6 2001 Deletion and mutation analysis of the promoter region of the IL-6 gene by using luciferase as a reporter showed that the DNA segment between -228 and -150 bp containing the cAMP response element (CRE) site played a critical role. Cyclic AMP 173-177 interleukin 6 Homo sapiens 61-65 11886504-4 2001 Activators for PPAR-alpha (WY-14,643, clofibrate) were shown to reverse ultraviolet-B-light-mediated expression of inflammatory cytokines (interleukin-6, interleukin-8). Clofibrate 38-48 interleukin 6 Homo sapiens 139-152 11717335-3 2001 Because dexamethasone interferes with NF-kappaB activation, we determined whether dexamethasone inhibits prostate cancer growth by working through the glucocorticoid receptor (GR) to interfere with NF-kappaB-IL-6 pathway. Dexamethasone 82-95 interleukin 6 Homo sapiens 208-212 11717335-11 2001 Dexamethasone increased IkappaBalpha protein levels and the cytosolic accumulation of NF-kappaB in DU145 cells and decreased secreted IL-6 levels to 37 pg/mL (95% confidence interval [CI] = 33 pg/mL to 41 pg/mL), compared with 164 pg/mL (95% CI = 162 pg/mL to 166 pg/mL) secreted by ethanol-treated control cells. Dexamethasone 0-13 interleukin 6 Homo sapiens 134-138 11717335-14 2001 CONCLUSION: Dexamethasone inhibited the growth of GR-positive cancers, possibly through the disruption of the NF-kappaB-IL-6 pathway. Dexamethasone 12-25 interleukin 6 Homo sapiens 120-124 11695972-8 2001 RESULTS: The tumor IL-6 content was the independent factor that influenced the creatinine height index in the elderly patients, whereas Dukes classification was the only independent factor that influenced the creatinine height index in the younger patients. Creatinine 79-89 interleukin 6 Homo sapiens 19-23 11641355-12 2001 A significant correlation (P = 0.004) between resting IL-6 and urinary norepinephrine excretion rates was found over the course of time while at altitude. Norepinephrine 71-85 interleukin 6 Homo sapiens 54-58 11687440-9 2001 Differences between pre-antibiotic and follow-up cytokine/creatinine ratios were significant for IL-1 beta, IL-6, and IL-8 (P < 0.01). Creatinine 58-68 interleukin 6 Homo sapiens 108-112 11687440-10 2001 Differences between pre-antibiotic and control cytokine/creatinine ratios were also significant for IL-1 beta, IL-6, and IL-8 (P < 0.01). Creatinine 56-66 interleukin 6 Homo sapiens 111-115 11675420-6 2001 At regular time intervals, the ability of HPMC to secrete cytokines (interleukin-6 [IL-6]) and extracellular matrix molecules (fibronectin) was evaluated. hydroxypropylmethylcellulose-lactose matrix 42-46 interleukin 6 Homo sapiens 69-82 11692108-6 2001 A selective MAP kinase kinase inhibitor, PD98059, inhibited IL-17-induced IL-6 and IL-8. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 41-48 interleukin 6 Homo sapiens 74-78 11747626-6 2001 In human osteoblasts (SaM-1 cells) treated with 10 microg/ml LPS, increases in IL-6 mRNA and synthesis were inhibited by anti-CD14 antibody (MEM-18), PD98059 (an inhibitor of classic mitogen-activated protein kinase [MAPK]), or SB203580 (an inhibitor of p38 MAPK) but were not inhibited by H-89 (an inhibitor of protein kinase A [PKA]) and calphostin C (an inhibitor of protein kinase C [PKC]). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 150-157 interleukin 6 Homo sapiens 79-83 11903746-12 2001 Interleukin-6 production increased to 288 +/- 48, 1195 +/- 86 and 247 +/- 35 pg/mL per 10(6) cells after ethanol, acetaldehyde and LPS exposure, and increased further with LPS pretreatment in ethanol-exposed cells (680 +/- 23 pg/mL 10(6) cells). Ethanol 105-112 interleukin 6 Homo sapiens 0-13 11903746-12 2001 Interleukin-6 production increased to 288 +/- 48, 1195 +/- 86 and 247 +/- 35 pg/mL per 10(6) cells after ethanol, acetaldehyde and LPS exposure, and increased further with LPS pretreatment in ethanol-exposed cells (680 +/- 23 pg/mL 10(6) cells). Ethanol 192-199 interleukin 6 Homo sapiens 0-13 11747626-7 2001 Furthermore, LPS-induced IL-6 synthesis was inhibited by curcumin (an inhibitor of activating protein-1 [AP-1]) but not by pyrrolidine dithiocarbamate (PDTC) (an inhibitor of nuclear factor kappa B [NF-kappaB]). Curcumin 57-65 interleukin 6 Homo sapiens 25-29 12536495-0 2001 [Influence of low-molecular weight heparin on urine interleukin-6 in patients with proliferative glomerulonephritis]. Heparin 35-42 interleukin 6 Homo sapiens 52-65 11719636-8 2001 GC sensitivity was assessed in vitro by dexamethasone inhibition of lipopolysaccharide-stimulated production of interleukin-6 and tumor necrosis factor-alpha. Dexamethasone 40-53 interleukin 6 Homo sapiens 112-157 12536495-1 2001 OBJECTIVE: To explore the influence of low-molecular weight heparin (LMWH) on interleukin-6 (IL-6) in patients with proliferative glomerulonephritis, 24 patients which had been distinctly diagnosed by renal biopsy were randomly divided into a control group (n = 12) and a treatment group (n = 12). Heparin 60-67 interleukin 6 Homo sapiens 78-91 12536495-1 2001 OBJECTIVE: To explore the influence of low-molecular weight heparin (LMWH) on interleukin-6 (IL-6) in patients with proliferative glomerulonephritis, 24 patients which had been distinctly diagnosed by renal biopsy were randomly divided into a control group (n = 12) and a treatment group (n = 12). Heparin 60-67 interleukin 6 Homo sapiens 93-97 11704591-7 2001 Post hoc analysis revealed a progressive increase in the IL-6 response to exercise, with the lowest increase observed in control subjects (11.8 +/- 4.6 pg/L/kJ), higher increases in patients with CF treated with ibuprofen (23.4 +/- 7.7 pg/L/kJ), and highest in subjects with CF not receiving ibuprofen (29.2 +/- 7.5 pg/L/kJ). Ibuprofen 212-221 interleukin 6 Homo sapiens 57-61 11594781-1 2001 We previously demonstrated that exposure of CCL39 lung fibroblasts to alpha-thrombin inhibits interleukin-6 (IL-6)-induced tyrosine phosphorylation of Stat3 (signal transducers and activators of transcription 3) via activation of mitogen-activated protein (MAP) kinase kinase 1 [Bhat et al. Tyrosine 123-131 interleukin 6 Homo sapiens 94-107 11594781-1 2001 We previously demonstrated that exposure of CCL39 lung fibroblasts to alpha-thrombin inhibits interleukin-6 (IL-6)-induced tyrosine phosphorylation of Stat3 (signal transducers and activators of transcription 3) via activation of mitogen-activated protein (MAP) kinase kinase 1 [Bhat et al. Tyrosine 123-131 interleukin 6 Homo sapiens 109-113 11594781-8 2001 We demonstrate that, although both IL-6 and OSM belong to the same cytokine family, alpha-thrombin inhibited only the IL-6-induced Stat3 tyrosine phosphorylation. Tyrosine 137-145 interleukin 6 Homo sapiens 118-122 11704591-7 2001 Post hoc analysis revealed a progressive increase in the IL-6 response to exercise, with the lowest increase observed in control subjects (11.8 +/- 4.6 pg/L/kJ), higher increases in patients with CF treated with ibuprofen (23.4 +/- 7.7 pg/L/kJ), and highest in subjects with CF not receiving ibuprofen (29.2 +/- 7.5 pg/L/kJ). Ibuprofen 292-301 interleukin 6 Homo sapiens 57-61 11597988-8 2001 PD98059 and SB203580 inhibited Ang II-induced IL-6 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 interleukin 6 Homo sapiens 46-50 11597988-0 2001 ERK and p38 MAPK, but not NF-kappaB, are critically involved in reactive oxygen species-mediated induction of IL-6 by angiotensin II in cardiac fibroblasts. Reactive Oxygen Species 64-87 interleukin 6 Homo sapiens 110-114 11597988-12 2001 Collectively, these data indicated that Ang II stimulated ROS production via the AT1 receptor and NADH/NADPH oxidase, and that these ROS mediated activation of MAPKs, which culminated in IL-6 gene expression through a CRE-dependent, but not NF-kappaB-dependent, pathway in cardiac fibroblasts. Reactive Oxygen Species 133-136 interleukin 6 Homo sapiens 187-191 11597988-4 2001 We first confirmed that antioxidant N-acetylcysteine, superoxide scavenger Tiron, and DPI suppressed Ang II-induced IL-6 expression. Acetylcysteine 36-52 interleukin 6 Homo sapiens 116-120 11597988-4 2001 We first confirmed that antioxidant N-acetylcysteine, superoxide scavenger Tiron, and DPI suppressed Ang II-induced IL-6 expression. Superoxides 54-64 interleukin 6 Homo sapiens 116-120 11728077-9 2001 No differences were noted between hips and knees for any of the variables, except in the levels of IL-6, where higher levels were found in THRs. Threonine 139-143 interleukin 6 Homo sapiens 99-103 11820460-1 2001 We analyzed the influence of heparins (unfractionated heparin, UFH and low molecular weight heparin certoparin) on the generation of IL-1ra, IL-6, IL-10, and IL-12p40 and from leukocyte fractions in vitro. Heparin 29-37 interleukin 6 Homo sapiens 141-145 11583728-6 2001 The cilostazol-induced changes in the IL-6 were positively related to those of triglycerides in the cilostazol group (r=0.63, P<0.05) and negatively related to those of HDL-C (r=-0.55, P<0.05). Triglycerides 79-92 interleukin 6 Homo sapiens 38-42 11594953-7 2001 Interleukin 6 and IL-8 were increased by 10 microg/mL of CsA, whereas transforming growth factor beta, PIIIP, and total protein were unaffected. Cyclosporine 57-60 interleukin 6 Homo sapiens 0-13 11594953-9 2001 Long-term exposure to CsA reduced IL-6 but did not modify PIIIP production. Cyclosporine 22-25 interleukin 6 Homo sapiens 34-38 11583728-3 2001 Interleukin-6 (IL-6) suppresses the activity of lipoprotein lipase, which modulates the metabolism of triglycerides and HDL-C. To determine whether a reduction of IL-6 contributes to the improvement of lipid profiles, we prospectively investigated the effect of cilostazol (n=16, 100 mg, twice daily) on the changes of lipid profiles and on the association with the changes of IL-6 compared with those of pentoxifylline (n=16, 400 mg, bid) in patients with IC. Triglycerides 102-115 interleukin 6 Homo sapiens 0-13 11583728-3 2001 Interleukin-6 (IL-6) suppresses the activity of lipoprotein lipase, which modulates the metabolism of triglycerides and HDL-C. To determine whether a reduction of IL-6 contributes to the improvement of lipid profiles, we prospectively investigated the effect of cilostazol (n=16, 100 mg, twice daily) on the changes of lipid profiles and on the association with the changes of IL-6 compared with those of pentoxifylline (n=16, 400 mg, bid) in patients with IC. Triglycerides 102-115 interleukin 6 Homo sapiens 15-19 11574475-3 2001 The IFNGR1 signal-transducing subunit of the IFN-gamma receptor is tyrosine phosphorylated through the chimeric receptors and the endogenous IL-6 and OSM receptors. Tyrosine 67-75 interleukin 6 Homo sapiens 141-145 11781188-6 2001 Pre-treatment with BSO, prior to exposure to LPS augmented, in a dose-dependent manner, LPS-induced TNF-alpha and IL-6 biosynthesis, an effect associated with the induction of intracellular accumulation of reactive oxygen species (ROS). Reactive Oxygen Species 206-229 interleukin 6 Homo sapiens 114-118 16134523-0 2001 [Regulatory effects of mifepristone and progesterone on the secretion of interleukin-6 by cultured eutopic and etopic endometrial cells]. Progesterone 40-52 interleukin 6 Homo sapiens 73-86 11713366-2 2001 We have here investigated the potential effect of Dex in U1 cells stimulated with interleukin-6 (IL-6), a cytokine inducing virus expression by acting mostly at a post-transcriptional level on the virus life cycle. Dexamethasone 50-53 interleukin 6 Homo sapiens 82-95 11713366-2 2001 We have here investigated the potential effect of Dex in U1 cells stimulated with interleukin-6 (IL-6), a cytokine inducing virus expression by acting mostly at a post-transcriptional level on the virus life cycle. Dexamethasone 50-53 interleukin 6 Homo sapiens 97-101 11713366-9 2001 No substantial HIV RNA accumulation was demonstrated in U1 cells co-stimulated with IL-6 and Dex, whereas IL-6 upregulated the expression of MCP-1 RNA, and this effect was inhibited by Dex. Dexamethasone 185-188 interleukin 6 Homo sapiens 106-110 11713366-10 2001 In contrast, Dex potentiated IL-6 induced activation of AP-1 and ERK1/2 MAPK phosphorylation, as revealed by EMSA. Dexamethasone 13-16 interleukin 6 Homo sapiens 29-33 16134523-1 2001 OBJECTIVE: To investigate the regulatory effects of mifepristone and progesterone on the secretion of interleukin-6 (IL-6) by endometrial and endometriosis cells in vitro. Progesterone 69-81 interleukin 6 Homo sapiens 102-115 16134523-1 2001 OBJECTIVE: To investigate the regulatory effects of mifepristone and progesterone on the secretion of interleukin-6 (IL-6) by endometrial and endometriosis cells in vitro. Progesterone 69-81 interleukin 6 Homo sapiens 117-121 16134523-5 2001 Progesterone also inhibited IL-6 secretion of ectopic endometrial cells, with (2 575.89 +/- 119.75) microg/L in the 1 x 10(-7) mol/L group (P < 0.05) and (1 736.25 +/- 750.89) microg/L in the 10(-5) mol/L group (P < 0.01). Progesterone 0-12 interleukin 6 Homo sapiens 28-32 11551520-5 2001 In the present study, we demonstrated that cepharanthine suppresses the production of inflammatory cytokines and a chemokine, i.e. TNF-alpha, interleukin (IL)-1beta, IL-6, and IL-8, in human monocytic cell cultures, including primary monocyte/macrophage cultures. cepharanthine 43-56 interleukin 6 Homo sapiens 166-170 11593406-2 2001 IL-6 also confers protection against Dexamethasone (Dex)-induced apoptosis via activation of protein tyrosine phosphatase (SHP2). Dexamethasone 37-50 interleukin 6 Homo sapiens 0-4 11593406-2 2001 IL-6 also confers protection against Dexamethasone (Dex)-induced apoptosis via activation of protein tyrosine phosphatase (SHP2). Dexamethasone 37-40 interleukin 6 Homo sapiens 0-4 11593406-7 2001 We demonstrate that Dex-induced apoptosis in MM.1S cells is mediated by downstream activation of caspase-9, with resultant caspase-3 cleavage; and conversely, that IL-6 triggers activation of PI3-K and its association with SHP2, inactivates caspase-9, and protects against Dex-induced apoptosis. Dexamethasone 20-23 interleukin 6 Homo sapiens 164-168 11593406-8 2001 LY294002 completely abrogates this signaling cascade, further confirming the importance of PI3-K/Akt signaling in conferring the protective effect of IL-6 against Dex-induced apoptosis. Dexamethasone 163-166 interleukin 6 Homo sapiens 150-154 11593385-10 2001 Finally, overexpression of IL-6 in C33A cells caused a markable resistance to apoptosis induced by doxorubicin or cisplatin. Doxorubicin 99-110 interleukin 6 Homo sapiens 27-31 11593385-10 2001 Finally, overexpression of IL-6 in C33A cells caused a markable resistance to apoptosis induced by doxorubicin or cisplatin. Cisplatin 114-123 interleukin 6 Homo sapiens 27-31 11558598-1 2001 Human interleukin 6 (hIL-6), which is a cytokine involved in diverse biological activities, consists of a four-helix bundle with two disulfide bonds. Disulfides 133-142 interleukin 6 Homo sapiens 6-19 11418615-11 2001 We observed that the anti-inflammatory action of PPAR alpha is not restricted to fibrinogen but also applies to other acute phase genes containing a C/EBP response element; it also occurs under conditions in which the stimulating action of IL-6 is potentiated by dexamethasone. Dexamethasone 263-276 interleukin 6 Homo sapiens 240-244 11594792-3 2001 Plasma IL-6 concentrations (92.3+/- 31.9 pg/ml) in elderly patients anesthetized with propofol and fentanyl were significantly higher at the end of the operation than that (57.9+/-36.7 pg/ml) of elderly patients anesthetized with sevoflurane and fentanyl. Sevoflurane 230-241 interleukin 6 Homo sapiens 7-11 11594792-5 2001 Plasma IL-6 production after surgical trauma in elderly patients with total intravenous anesthesia with propofol was significantly higher than that in elderly patients with sevoflurane anesthesia. Sevoflurane 173-184 interleukin 6 Homo sapiens 7-11 11594793-7 2001 When the levels of pro-inflammatory cytokines were measured, a significant time-dependent increase in TNF-alpha, IL-6 and IL-1beta production was observed in FS-derived cultures, but not in VP-derived cultures. phenylalanylserine 158-160 interleukin 6 Homo sapiens 113-117 11558598-1 2001 Human interleukin 6 (hIL-6), which is a cytokine involved in diverse biological activities, consists of a four-helix bundle with two disulfide bonds. Disulfides 133-142 interleukin 6 Homo sapiens 21-26 12604011-3 2001 Particular hydroxylation patterns of the B ring of the flavones permit them to inhibit histamine, tryptase, interleukin-6 and interleukin-8 release from human umbilical-cord derived cultured mast cells, as well as from macrophages. Flavones 55-63 interleukin 6 Homo sapiens 108-121 11766126-11 2001 Recombinant human IL-6 (rhIL-6) exposed to HD lacked the second disulfide bridge and was partially unfolded, as determined by nuclear magnetic resonance-nuclear Overhauser enhancement and exchange spectroscopy (NMR-NOESY). Disulfides 64-73 interleukin 6 Homo sapiens 18-22 11536174-2 2001 In this report, we show that lung schistosomula selectively induce the synthesis of IL-6 mRNA and protein in cultured human and mouse lung microvascular endothelial cells (EC) and that parasite excretory/secretory lipophilic compounds, particularly prostaglandin E(2), are responsible for this effect. Dinoprostone 249-267 interleukin 6 Homo sapiens 84-88 11525435-10 2001 RESULTS: At the 24-hour time point, 1 nM nicotine stimulated IL-6 production compared to control (P=0.02). Nicotine 41-49 interleukin 6 Homo sapiens 61-65 11544464-11 2001 IL-17 did enhance the production of pro-fibrotic cytokines (IL-6 and IL-11) by fibroblasts, and this was inhibited by dexamethasone. Dexamethasone 118-131 interleukin 6 Homo sapiens 60-64 11592593-7 2001 Levels of ACTH and DHEAS in relation to serum IL-6 or TNF were higher in Co as compared to the cholestatic subgroup without tumours, whereas serum cortisol in relation to these cytokines was similar. Dehydroepiandrosterone Sulfate 19-24 interleukin 6 Homo sapiens 46-50 11562149-13 2001 Increased release of MCP-1 from fibroblasts exposed to titanium and PMMA particles coincided with increased release of IL-6. Titanium 55-63 interleukin 6 Homo sapiens 119-123 11429412-4 2001 Here we show that the ER agonist 17 beta-estradiol completely abolished IL-6-inducible MM cell proliferation. Estradiol 33-50 interleukin 6 Homo sapiens 72-76 11523624-7 2001 Following the induction chemotherapy, the serum calcium level was promptly normalized accompanied with decreases in serum TNF-alpha, IL-6 and soluble IL-2 receptor values to 34 pg/ml, 6.35 pg/ml, and 737 U/ml, respectively. Calcium 48-55 interleukin 6 Homo sapiens 133-137 11505128-15 2001 CONCLUSIONS: Low cholesterol and lipoprotein concentrations found in critically ill surgical patients correlate with interleukin-6, soluble interleukin-2 receptor, and interleukin-10 concentrations and predict clinical outcomes. Cholesterol 17-28 interleukin 6 Homo sapiens 117-130 11459775-3 2001 We therefore examined the effects of the PPARalpha activator fenofibrate and the GR activator dexamethasone on TNFalpha-stimulated expression of IL-6 and vascular cell adhesion molecule-1 in vascular endothelial cells. Dexamethasone 94-107 interleukin 6 Homo sapiens 145-149 11459775-4 2001 Both fenofibrate and dexamethasone reduced TNFalpha-induced IL-6 production in human vascular endothelial cells, but only fenofibrate reduced TNFalpha-stimulated vascular cell adhesion molecule-1 expression in these cells. Dexamethasone 21-34 interleukin 6 Homo sapiens 60-64 11459775-6 2001 EMSA demonstrated that both fenofibrate and dexamethasone reduced nuclear factor-kappaB binding to its recognition site on the IL-6 promoter, but only fenofibrate reduced such binding to the vascular cell adhesion molecule-1 promoter. Dexamethasone 44-57 interleukin 6 Homo sapiens 127-131 11479143-0 2001 Interaction of interleukin-6 on human granulosa cell steroid secretion. Steroids 53-60 interleukin 6 Homo sapiens 15-28 11479143-4 2001 The possibility that IL-6 may also influence the basal and FSH-stimulated production of estradiol (E2) and progesterone (Prog) by GCs in vitro was also investigated. Estradiol 88-97 interleukin 6 Homo sapiens 21-25 11479143-4 2001 The possibility that IL-6 may also influence the basal and FSH-stimulated production of estradiol (E2) and progesterone (Prog) by GCs in vitro was also investigated. Progesterone 107-119 interleukin 6 Homo sapiens 21-25 11509812-5 2001 Our results showed that dexamethasone, budesonide and rIL-10 significantly inhibited both IL-6 and TNF-alpha production in the THP-1 cell line stimulated by lipopolysaccharide and Ureaplasma urealyticum antigen. Dexamethasone 24-37 interleukin 6 Homo sapiens 90-94 11570587-6 2001 Our studies on the regulation of IL-10 secretion in OVCAR-3 revealed that (1) proinflammatory stimuli IL-1beta and TNF-alpha, but not LPS, enhance IL-10 secretion, (2) IL-6 has no influence on the release of IL-10, (3) prostaglandin E2 influences neither the spontaneous nor the TNF-alpha- or IL-1beta-stimulated IL-10 production and (4) interferon-gamma inhibits IL-10 secretion. Dinoprostone 219-235 interleukin 6 Homo sapiens 168-172 11556519-8 2001 RESULTS: We have demonstrated that aceclofenac, 4"-hydroxyaceclofenac and diclofenac significantly decreased interleukin-6 production at concentrations ranged among 1 to 30 microM and fully blocked prostaglandin E2 synthesis by IL-1beta- or LPS-stimulated human chondrocytes. Dinoprostone 198-214 interleukin 6 Homo sapiens 109-122 11525435-12 2001 A synergistic effect upregulating IL-6 was observed with combined treatment of 1 mM nicotine and E. coli LPS or P gingivalis LPS at the 24-hour time point (P<0.0005 and P=0.002, respectively). Nicotine 84-92 interleukin 6 Homo sapiens 34-38 11525435-14 2001 CONCLUSIONS: These results demonstrate that nicotine by itself can stimulate HGF IL-6 and IL-8 production. Nicotine 44-52 interleukin 6 Homo sapiens 81-85 11335711-0 2001 Sequential activation of Rac-1, SEK-1/MKK-4, and protein kinase Cdelta is required for interleukin-6-induced STAT3 Ser-727 phosphorylation and transactivation. Serine 115-118 interleukin 6 Homo sapiens 87-100 11335711-1 2001 Activation of signal transducer and activator of transcription 3 (STAT3) by interleukin-6 (IL-6) involves phosphorylation of Tyr-705 and Ser-727, both of which are critical for STAT3 transactivation. Tyrosine 125-128 interleukin 6 Homo sapiens 76-89 11335711-8 2001 Furthermore, the IL-6-induced PKCdelta Thr-505 and STAT3 Ser-727 phosphorylation were only observed in nuclear fractions of HepG2 cells. Threonine 39-42 interleukin 6 Homo sapiens 17-21 11335711-8 2001 Furthermore, the IL-6-induced PKCdelta Thr-505 and STAT3 Ser-727 phosphorylation were only observed in nuclear fractions of HepG2 cells. Serine 57-60 interleukin 6 Homo sapiens 17-21 11335711-1 2001 Activation of signal transducer and activator of transcription 3 (STAT3) by interleukin-6 (IL-6) involves phosphorylation of Tyr-705 and Ser-727, both of which are critical for STAT3 transactivation. Tyrosine 125-128 interleukin 6 Homo sapiens 91-95 11335711-1 2001 Activation of signal transducer and activator of transcription 3 (STAT3) by interleukin-6 (IL-6) involves phosphorylation of Tyr-705 and Ser-727, both of which are critical for STAT3 transactivation. Serine 137-140 interleukin 6 Homo sapiens 76-89 11335711-1 2001 Activation of signal transducer and activator of transcription 3 (STAT3) by interleukin-6 (IL-6) involves phosphorylation of Tyr-705 and Ser-727, both of which are critical for STAT3 transactivation. Serine 137-140 interleukin 6 Homo sapiens 91-95 11335711-2 2001 Here, we demonstrate that IL-6 activates Rac-1 and SEK-1/MKK-4 of the stress-activated protein kinase pathway, as well as protein kinase Cdelta (PKCdelta), as indicated by PKCdelta Thr-505 phosphorylation. Threonine 181-184 interleukin 6 Homo sapiens 26-30 11510989-6 2001 It is now apparent that the constitutive elevation in cAMP level induced by the Gsalpha mutations leads to alterations in the expression of several target genes whose promoters contain cAMP-responsive elements, such as c-fos, c-jun, Il-6 and Il-11. Cyclic AMP 54-58 interleukin 6 Homo sapiens 233-237 11466099-9 2001 Positive associations persisted after adjustment for body mass index, family history of diabetes, smoking, exercise, use of alcohol, and hormone replacement therapy; multivariate relative risks for the highest vs lowest quartiles were 2.3 for IL-6 (95% CI, 0.9-5.6; P for trend =.07) and 4.2 for CRP (95% CI, 1.5-12.0; P for trend =.001). Alcohols 124-131 interleukin 6 Homo sapiens 243-247 11356822-4 2001 Interleukin-6, a growth factor for MM, blocks Dex-induced apoptosis and prevents release of Smac. Dexamethasone 46-49 interleukin 6 Homo sapiens 0-13 11473581-6 2001 We provide evidence that the cytoplasmic tyrosine residues of IFNAR-1, which remains phosphorylated by a weak IFN-alpha/beta stimulation, provide docking sites for Stat1 and Stat3 to form homo- or heterodimers following IL-6 stimulation. Tyrosine 41-49 interleukin 6 Homo sapiens 220-224 11453645-5 2001 Blockade of the generation of intracellular ROS by antioxidants inhibited VEGF-induced NF-kappaB activation, IL-6 expression, and cell migration indicating that generation of ROS was required for NF-kappaB activation and the chemotactic activity of VEGF. Reactive Oxygen Species 44-47 interleukin 6 Homo sapiens 109-113 11453645-5 2001 Blockade of the generation of intracellular ROS by antioxidants inhibited VEGF-induced NF-kappaB activation, IL-6 expression, and cell migration indicating that generation of ROS was required for NF-kappaB activation and the chemotactic activity of VEGF. Reactive Oxygen Species 175-178 interleukin 6 Homo sapiens 109-113 11509008-5 2001 We examined the effects of physiological and supraphysiological concentrations of 17beta-estradiol (E2) and cortisol on basal and IL-1beta-induced IL-6 release in the medium. Estradiol 82-98 interleukin 6 Homo sapiens 147-151 11415991-0 2001 Differential effects of estradiol on the adrenocorticotropin responses to interleukin-6 and interleukin-1 in the monkey. Estradiol 24-33 interleukin 6 Homo sapiens 74-87 11510989-6 2001 It is now apparent that the constitutive elevation in cAMP level induced by the Gsalpha mutations leads to alterations in the expression of several target genes whose promoters contain cAMP-responsive elements, such as c-fos, c-jun, Il-6 and Il-11. Cyclic AMP 185-189 interleukin 6 Homo sapiens 233-237 11449408-6 2001 The percentage of IL-6 and TNF-alpha-producing monocytes after 8 h of culture without stimulation revealed significant lower values for monensin-treated than for brefeldin A-treated monocytes. Monensin 136-144 interleukin 6 Homo sapiens 18-22 11459382-8 2001 The changes in the tryptophan/CAA ratio from the end of term to the early puerperium were significantly and inversely related to serum IL-6, IL-IRA and LIF-R. Tryptophan 19-29 interleukin 6 Homo sapiens 135-139 11429693-8 2001 Thus, the YXXQ motif regulates STAT3 activities in two ways in response to even a low concentration of IL-6: it recruits STAT3 to the receptor for tyrosine phosphorylation, and activates an unidentified H7-sensitive pathway leading to the serine phosphorylation of STAT3. Tyrosine 147-155 interleukin 6 Homo sapiens 103-107 11429693-4 2001 Here we show that IL-6 activates at least two distinct STAT3 serine kinase pathways and that an H7-sensitive pathway is dominant over a PD98059-sensitive one in HepG2 cells stimulated with a low concentration of IL-6. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 136-143 interleukin 6 Homo sapiens 212-216 11429693-8 2001 Thus, the YXXQ motif regulates STAT3 activities in two ways in response to even a low concentration of IL-6: it recruits STAT3 to the receptor for tyrosine phosphorylation, and activates an unidentified H7-sensitive pathway leading to the serine phosphorylation of STAT3. Serine 239-245 interleukin 6 Homo sapiens 103-107 11491660-0 2001 Hydrogen peroxide activates NFkappaB and the interleukin-6 promoter through NFkappaB-inducing kinase. Hydrogen Peroxide 0-17 interleukin 6 Homo sapiens 45-58 11503575-7 2001 An inverse correlation between the IL-6 levels and both, the hemoglobin concentration and the serum iron was found, and there was a direct correlation between this cytokine values and the EPO levels. Iron 100-104 interleukin 6 Homo sapiens 35-39 11491660-3 2001 We found that H2O2 induced IL-6 expression through activation of the IL-6 promoter. Hydrogen Peroxide 14-18 interleukin 6 Homo sapiens 27-31 11491660-6 2001 Accordingly, we explored if H2O2 induces IL-6 expression through NIK. Hydrogen Peroxide 28-32 interleukin 6 Homo sapiens 41-45 11491660-3 2001 We found that H2O2 induced IL-6 expression through activation of the IL-6 promoter. Hydrogen Peroxide 14-18 interleukin 6 Homo sapiens 69-73 11491660-7 2001 In addition to H2O2 inducing NIK autophosphorylation, transfection of LNCaP cells with a dominant negative NIK diminished H2O2-mediated NFkappaB and IL-6 promoter activity. Hydrogen Peroxide 122-126 interleukin 6 Homo sapiens 149-153 11491660-8 2001 Taken together, these results demonstrate that H2O2 induces the IL-6 promoter by activating NFkappaB through NIK. Hydrogen Peroxide 47-51 interleukin 6 Homo sapiens 64-68 11389214-0 2001 Carbohydrate ingestion attenuates the increase in plasma interleukin-6, but not skeletal muscle interleukin-6 mRNA, during exercise in humans. Carbohydrates 0-12 interleukin 6 Homo sapiens 57-70 11389100-8 2001 Furthermore, when the motif of the nuclear factor for interleukin-6 expression site, the cyclic AMP response element, or both was subjected to point mutation, the constitutive luciferase activity was markedly reduced. Cyclic AMP 89-99 interleukin 6 Homo sapiens 54-67 11892999-9 2001 Furthermore, we have shown that the IL-6 receptor complex is functional in U-937-1 cells induced to differentiate towards a secretory macrophage by treatment with PMA. Tetradecanoylphorbol Acetate 163-166 interleukin 6 Homo sapiens 36-40 11378323-7 2001 We found that 0.5 M NaCl treatment increased mRNA levels of proinflammatory cytokines such as IL-1alpha, IL-6 and IL-8 as well as ICAM-1 in NHEK and IL-1alpha, IL-1beta and IL-6 mRNA levels in NHDF. Sodium Chloride 20-24 interleukin 6 Homo sapiens 105-109 11378323-7 2001 We found that 0.5 M NaCl treatment increased mRNA levels of proinflammatory cytokines such as IL-1alpha, IL-6 and IL-8 as well as ICAM-1 in NHEK and IL-1alpha, IL-1beta and IL-6 mRNA levels in NHDF. Sodium Chloride 20-24 interleukin 6 Homo sapiens 173-177 11378323-8 2001 In contrast, H2O2 treatment remarkably increased IL-10, GMCSF and ICAM-1 mRNA levels in NHEK, and IL-6 mRNA levels in HMVEC and NHDF. Hydrogen Peroxide 13-17 interleukin 6 Homo sapiens 98-102 11389214-2 2001 The present study was undertaken to examine the effects of exercise and carbohydrate (CHO) ingestion on interleukin-6 (IL-6) gene expression in skeletal muscle and plasma IL-6 concentration. Carbohydrates 72-84 interleukin 6 Homo sapiens 104-117 11389214-2 2001 The present study was undertaken to examine the effects of exercise and carbohydrate (CHO) ingestion on interleukin-6 (IL-6) gene expression in skeletal muscle and plasma IL-6 concentration. Carbohydrates 72-84 interleukin 6 Homo sapiens 119-123 11278795-6 2001 The analysis of 40 adipocyte genes showed that the response to cholesterol depletion implicated genes involved in cholesterol traffic (caveolin 2, scavenger receptor BI, and ATP binding cassette 1 genes) but also adipocyte-derived secretion products (tumor necrosis factor alpha, angiotensinogen, and interleukin-6) and proteins involved in energy metabolism (fatty acid synthase, GLUT 4, and UCP3). Cholesterol 63-74 interleukin 6 Homo sapiens 301-314 11337018-5 2001 STAT3 antisense cDNA blocked the expression and IL-6-induced tyrosine phosphorylation and DNA binding of STAT3, and resulted in reduction of both IL-6-induced growth arrest at G(0)/G(1) phase and macrophage differentiation in the M1 transformants. Tyrosine 61-69 interleukin 6 Homo sapiens 48-52 11337018-5 2001 STAT3 antisense cDNA blocked the expression and IL-6-induced tyrosine phosphorylation and DNA binding of STAT3, and resulted in reduction of both IL-6-induced growth arrest at G(0)/G(1) phase and macrophage differentiation in the M1 transformants. Tyrosine 61-69 interleukin 6 Homo sapiens 146-150 11390719-10 2001 In the whole population, IL-6 and TNF-alpha correlated negatively with EDV, HDL cholesterol, and positively with triglyceride, blood pressure, vWf, iCAM-1, vCAM-1 and E-selectin (r=-0.43 to +0.70, all P<0.05). Cholesterol 80-91 interleukin 6 Homo sapiens 25-29 11390719-10 2001 In the whole population, IL-6 and TNF-alpha correlated negatively with EDV, HDL cholesterol, and positively with triglyceride, blood pressure, vWf, iCAM-1, vCAM-1 and E-selectin (r=-0.43 to +0.70, all P<0.05). Triglycerides 113-125 interleukin 6 Homo sapiens 25-29 11278795-6 2001 The analysis of 40 adipocyte genes showed that the response to cholesterol depletion implicated genes involved in cholesterol traffic (caveolin 2, scavenger receptor BI, and ATP binding cassette 1 genes) but also adipocyte-derived secretion products (tumor necrosis factor alpha, angiotensinogen, and interleukin-6) and proteins involved in energy metabolism (fatty acid synthase, GLUT 4, and UCP3). Cholesterol 114-125 interleukin 6 Homo sapiens 301-314 11325811-9 2001 The IL-17-induced release of IL-6 and IL-8 was concentration-dependently inhibited by SB202190 and by PD98059 in bronchial epithelial cells without affecting cell proliferation or survival. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 102-109 interleukin 6 Homo sapiens 29-33 11342672-7 2001 Two cytokines, IFN-gamma and IL-6, were found to be responsible for the function of CD8(+) TS: In fact, counteraction of CD8(+) Ts suppression activity was obtained by blocking IFN-gamma with a specific Ab or by inhibiting CD8(+) Ts-mediated IL-6 secretion by an antisense oligonucleotide. Oligonucleotides 273-288 interleukin 6 Homo sapiens 29-33 11342615-7 2001 In addition, histamine induces a potent production of IL-6, IL-8, monocyte chemoattractant protein 1, and macrophage-inflammatory protein 1alpha by immature DC and also up-regulates IL-1beta, RANTES, and macrophage-inflammatory protein 1beta but not TNF-alpha and IL-12 mRNA expression. Histamine 13-22 interleukin 6 Homo sapiens 54-58 11325794-5 2001 In alveolar epithelial cells, pre-treatment (30 min) with Y-40138 reduced LPS-induced biosynthesis of IL-1 beta, IL-6 and TNF-alpha, an effect paralleled by up-regulating an anti-inflammatory counter-loop mediated through IL-10. Y 39041 58-65 interleukin 6 Homo sapiens 113-117 11436361-0 2001 Acute urticaria with elevated circulating interleukin-6 is resistant to anti-histamine treatment. Histamine 77-86 interleukin 6 Homo sapiens 42-55 11408018-3 2001 RESULTS: Acute ethanol exposure inhibited IL-6- or IFN-activated STAT in freshly isolated hepatocytes but not in cultured hepatocytes, HepG2 cells, or HepG2 cells transfected with alcohol dehydrogenase (ADH) or cytochrome P450(2E1). Ethanol 15-22 interleukin 6 Homo sapiens 42-54 11344240-5 2001 Chronic incubation of adipocytes with 1 nmol/L IL-6 during adipose differentiation reduced glycero-3-phosphate dehydrogenase (GPDH) activity, a marker of adipocyte differentiation, and triglyceride synthesis to 67 +/- 9% of the basal level (mean +/- SEM; P < 0.05) only on day 21. Triglycerides 185-197 interleukin 6 Homo sapiens 47-51 11436361-9 2001 In contrast, all but one patient without elevated circulating IL-6 was successfully treated with a H1 receptor antagonist, cetirizine. Cetirizine 123-133 interleukin 6 Homo sapiens 62-66 11336536-0 2001 Histamine-induced production of interleukin-6 and interleukin-8 by human coronary artery endothelial cells is enhanced by endotoxin and tumor necrosis factor-alpha. Histamine 0-9 interleukin 6 Homo sapiens 32-45 11336536-1 2001 In this study, we tested the synergy between histamine and LPS, and histamine and TNF-alpha, on endothelial cell production of interleukin-6 (IL-6), interleukin-8 (IL-8), and monocyte chemoattractant protein-1 (MCP-1). Histamine 45-54 interleukin 6 Homo sapiens 127-140 11336536-4 2001 The incubation of HCAEC with histamine resulted in low level induction of IL-6 and IL-8 production, which was dose-dependent and attained a plateau at a concentration of 10 microM. Histamine 29-38 interleukin 6 Homo sapiens 74-78 11336536-7 2001 In the presence of all stimulatory concentrations of LPS and TNF-alpha tested, histamine was shown to further enhance IL-6 and IL-8 production. Histamine 79-88 interleukin 6 Homo sapiens 118-122 11336536-1 2001 In this study, we tested the synergy between histamine and LPS, and histamine and TNF-alpha, on endothelial cell production of interleukin-6 (IL-6), interleukin-8 (IL-8), and monocyte chemoattractant protein-1 (MCP-1). Histamine 68-77 interleukin 6 Homo sapiens 127-140 11336536-10 2001 Since both LPS and TNF-alpha potentiated histamine-induced cytokine production, it is possible that these activators stimulate H-1 receptor expression and/or augment the signal transduction pathways leading to the expression of IL-6 and IL-8. Histamine 41-50 interleukin 6 Homo sapiens 228-232 11357886-4 2001 Cyclosporin A (CsA) also inhibited the anti-CD3/CD28 induced IL-6 production but was about 100 times less potent than FK506. Cyclosporine 0-13 interleukin 6 Homo sapiens 61-65 11304417-6 2001 The treatment of CD34-positive progenitor cells isolated from cord blood with cepharanthin (over 5 x 10(-10)g/ml) caused an increase in the formation of CFU-MK induced by the cocktail of thrombopoietin, interleukin (IL)-6 and IL-3. cepharanthine 78-90 interleukin 6 Homo sapiens 203-221 11356008-3 2001 Here, we report that IL-6 and 12-O-tetradecanoylphorbol-13-acetate (TPA) synergistically transactivate the IRE in HepG2 cells, which is coupled to a strong upregulation of c-Jun and c-Fos expression by TPA via the mitogen-activated protein kinase (MAPK) pathway. Tetradecanoylphorbol Acetate 202-205 interleukin 6 Homo sapiens 21-25 11333166-10 2001 Norepinephrine and interleukin-6 levels were substantially lower in patients on beta-blockers (28% and 61%, respectively). (2-benzoylethyl)trimethylammonium 80-84 interleukin 6 Homo sapiens 19-32 11396485-8 2001 Of the five antioxidants tested, only curcumin was able to inhibit IkappaBalpha degradation upstream and, hence, NF-kappaB DNA-binding activity and NF-kappaB-dependent expression of IL-6 downstream. Curcumin 38-46 interleukin 6 Homo sapiens 182-186 11283920-10 2001 In vitro exposure of MPC cultures to dexamethasone resulted in the down-regulation of IL-6, G-CSF, and GM-CSF in both normal and myeloma MPC cultures. Dexamethasone 37-50 interleukin 6 Homo sapiens 86-90 11357886-4 2001 Cyclosporin A (CsA) also inhibited the anti-CD3/CD28 induced IL-6 production but was about 100 times less potent than FK506. Cyclosporine 15-18 interleukin 6 Homo sapiens 61-65 11357886-5 2001 Dexamethasone (DEX) inhibited both anti-CD3/CD28 and LPS induced IL-6 production at almost the same concentration. Dexamethasone 0-13 interleukin 6 Homo sapiens 65-69 11357886-5 2001 Dexamethasone (DEX) inhibited both anti-CD3/CD28 and LPS induced IL-6 production at almost the same concentration. Dexamethasone 15-18 interleukin 6 Homo sapiens 65-69 11359654-8 2001 Both the direct and the amplifying effects of PAR agonist peptides on IL-6 production were pertussis toxin sensitive and caused an increase in the intracellular levels of calcium, implicating G-proteins and calcium mobilization in these pathways. Calcium 171-178 interleukin 6 Homo sapiens 70-74 15348300-1 2001 In order to evaluate if carbon coated polyethylene terephthalate (C-PET) could favor inflammatory reactions, the expression of interleukin-6 (IL-6) by cultured human umbilical vein endothelial cells was tested in vitro. Carbon 24-30 interleukin 6 Homo sapiens 127-140 15348300-1 2001 In order to evaluate if carbon coated polyethylene terephthalate (C-PET) could favor inflammatory reactions, the expression of interleukin-6 (IL-6) by cultured human umbilical vein endothelial cells was tested in vitro. Carbon 66-67 interleukin 6 Homo sapiens 127-140 11359654-8 2001 Both the direct and the amplifying effects of PAR agonist peptides on IL-6 production were pertussis toxin sensitive and caused an increase in the intracellular levels of calcium, implicating G-proteins and calcium mobilization in these pathways. Calcium 207-214 interleukin 6 Homo sapiens 70-74 11327082-7 2001 Fluprostenol, a selective FP receptor agonist, could mimic PGF2alpha-induced IL-6 production. fluprostenol 0-12 interleukin 6 Homo sapiens 77-81 11327082-8 2001 Since FP receptors are coupled to elevation of intracellular calcium and activation of protein kinase C (PKC), the mechanism of IL-6 production by PGF2alpha was investigated using TMB-8, an inhibitor of Ca2+ mobilization from intracellular stores, and calphostin C, an inhibitor of PKC. 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate 180-185 interleukin 6 Homo sapiens 128-132 11327082-9 2001 TMB-8 significantly suppressed PGF2alpha-induced IL-6 production, whereas calphostin C showed a stimulatory effect on PGF2alpha-induced IL-6 production. 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate 0-5 interleukin 6 Homo sapiens 49-53 11238657-7 2001 Inhibition of histamine-induced beta-glucuronidase and IL-6 release by fexofenadine was concentration dependent and displayed the characteristics of a competitive antagonism (K(d) = 89 nM). Histamine 14-23 interleukin 6 Homo sapiens 55-59 11238657-8 2001 These data demonstrate that histamine induces exocytosis and IL-6 production from human macrophages by activating H(1) receptor and by increasing [Ca(2+)](i) and they suggest that histamine may play a relevant role in the long-term sustainment of allergic inflammation in the airways. Histamine 28-37 interleukin 6 Homo sapiens 61-65 11238657-0 2001 Histamine induces exocytosis and IL-6 production from human lung macrophages through interaction with H1 receptors. Histamine 0-9 interleukin 6 Homo sapiens 33-37 11238657-8 2001 These data demonstrate that histamine induces exocytosis and IL-6 production from human macrophages by activating H(1) receptor and by increasing [Ca(2+)](i) and they suggest that histamine may play a relevant role in the long-term sustainment of allergic inflammation in the airways. Histamine 180-189 interleukin 6 Homo sapiens 61-65 11238657-2 2001 In the present study histamine (10(-9)-10(-6) M) increased in a concentration-dependent fashion the basal release of beta-glucuronidase (EC(50) = 8.2 +/- 3.5 x 10(-9) M) and IL-6 (EC(50) = 9.3 +/- 2.9 x 10(-8) M) from human lung macrophages. Histamine 21-30 interleukin 6 Homo sapiens 174-178 11238657-6 2001 Histamine-induced beta-glucuronidase and IL-6 release and [Ca(2+)](i) elevation were inhibited by the selective H(1) antagonist fexofenadine (10(-7)-10(-4) M), but not by the H(2) antagonist ranitidine. Histamine 0-9 interleukin 6 Homo sapiens 41-45 11181934-3 2001 Buthionine sulfoximine, an irreversible inhibitor of gamma-glutamylcysteine synthetase, the rate-limiting enzyme in glutathione (GSH) biosynthesis, induced intracellular reactive oxygen species (ROS) and the release of interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha. Reactive Oxygen Species 170-193 interleukin 6 Homo sapiens 249-286 11289091-0 2001 Plasma levels of interleukin-6 and interleukin-10 are affected by ketorolac as an adjunct to patient-controlled morphine after abdominal hysterectomy. Morphine 112-120 interleukin 6 Homo sapiens 17-30 11289091-2 2001 Therefore, the purpose of this study was to determine differences between morphine patient-controlled analgesia and a combination of morphine and ketorolac in interleukin-6 and interleukin-10 responses, and in analgesia and morphine-related side effects. Morphine 74-82 interleukin 6 Homo sapiens 159-172 11289091-2 2001 Therefore, the purpose of this study was to determine differences between morphine patient-controlled analgesia and a combination of morphine and ketorolac in interleukin-6 and interleukin-10 responses, and in analgesia and morphine-related side effects. Morphine 133-141 interleukin 6 Homo sapiens 159-172 11289091-2 2001 Therefore, the purpose of this study was to determine differences between morphine patient-controlled analgesia and a combination of morphine and ketorolac in interleukin-6 and interleukin-10 responses, and in analgesia and morphine-related side effects. Morphine 133-141 interleukin 6 Homo sapiens 159-172 11405518-11 2001 Compared to the unstimulated CBD PBMNs, beryllium stimulated significant IFN-gamma, TNF-alpha, IL-2, IL-6 and IL-10 production. Beryllium 40-49 interleukin 6 Homo sapiens 101-105 11222496-9 2001 By blocking activation of ERK1/2 with a MEK-specific inhibitor, PD98059, CD40-dependent secretion of the pro-inflammatory cytokines, TNF-alpha, IL-6 and IL-8, was demonstrated to be linked to the ERK1/2 pathway. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 64-71 interleukin 6 Homo sapiens 144-148 11270639-8 2001 CONCLUSIONS: IL-6 up-regulates uterine OTR mRNA expression and binding capacity in cultured human myocytes most likely through tyrosine and serine phosphorylation pathways involving the nuclear factor STAT-3. Tyrosine 127-135 interleukin 6 Homo sapiens 13-17 11270639-8 2001 CONCLUSIONS: IL-6 up-regulates uterine OTR mRNA expression and binding capacity in cultured human myocytes most likely through tyrosine and serine phosphorylation pathways involving the nuclear factor STAT-3. Serine 140-146 interleukin 6 Homo sapiens 13-17 11231856-6 2001 RESULTS: Postoperative levels of serum and peritoneal IL-6 and levels of C-reactive protein were significantly lower in the steroid group than in controls. Steroids 124-131 interleukin 6 Homo sapiens 54-58 11231856-11 2001 CONCLUSIONS: Preoperative steroid administration significantly elevated anti-inflammatory cytokine IL-10 levels, suppressed the levels of inflammatory cytokines IL-6 and C-reactive protein, and prevented postoperative elevation of total bilirubin values. Steroids 26-33 interleukin 6 Homo sapiens 161-165 11405518-2 2001 Beryllium induces interferon-gamma (IFN-gamma), interleukin-2 (IL-2), tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-10 (IL-10) from BAL cells. Beryllium 0-9 interleukin 6 Homo sapiens 112-125 11405518-2 2001 Beryllium induces interferon-gamma (IFN-gamma), interleukin-2 (IL-2), tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-10 (IL-10) from BAL cells. Beryllium 0-9 interleukin 6 Homo sapiens 127-131 11354255-3 2001 Recent studies have revealed that cells possess two cholesterol-sensors: (a) Receptor-Ck which senses the extracellular cholesterol and initiates signalling pathway responsible for the regulation of genes involved in the cell cycle, cell death, cellular cholesterol homeostasis and cytokines including IL-6; (b) LxR alpha which senses intracellular oxysterols and controls genes involved in cell death, cellular cholesterol homeostasis and cytokine IL-8. Cholesterol 52-63 interleukin 6 Homo sapiens 302-306 11354255-4 2001 These cholesterol sensors define the molecular mechanism responsible for cholesterol-depended regulation of cellular synthesis and secretion of cytokines (IL-6, IL-8) within arterial wall. Cholesterol 6-17 interleukin 6 Homo sapiens 155-159 11354255-4 2001 These cholesterol sensors define the molecular mechanism responsible for cholesterol-depended regulation of cellular synthesis and secretion of cytokines (IL-6, IL-8) within arterial wall. Cholesterol 73-84 interleukin 6 Homo sapiens 155-159 11354255-3 2001 Recent studies have revealed that cells possess two cholesterol-sensors: (a) Receptor-Ck which senses the extracellular cholesterol and initiates signalling pathway responsible for the regulation of genes involved in the cell cycle, cell death, cellular cholesterol homeostasis and cytokines including IL-6; (b) LxR alpha which senses intracellular oxysterols and controls genes involved in cell death, cellular cholesterol homeostasis and cytokine IL-8. Cholesterol 120-131 interleukin 6 Homo sapiens 302-306 11354255-3 2001 Recent studies have revealed that cells possess two cholesterol-sensors: (a) Receptor-Ck which senses the extracellular cholesterol and initiates signalling pathway responsible for the regulation of genes involved in the cell cycle, cell death, cellular cholesterol homeostasis and cytokines including IL-6; (b) LxR alpha which senses intracellular oxysterols and controls genes involved in cell death, cellular cholesterol homeostasis and cytokine IL-8. Cholesterol 120-131 interleukin 6 Homo sapiens 302-306 11354255-3 2001 Recent studies have revealed that cells possess two cholesterol-sensors: (a) Receptor-Ck which senses the extracellular cholesterol and initiates signalling pathway responsible for the regulation of genes involved in the cell cycle, cell death, cellular cholesterol homeostasis and cytokines including IL-6; (b) LxR alpha which senses intracellular oxysterols and controls genes involved in cell death, cellular cholesterol homeostasis and cytokine IL-8. Cholesterol 120-131 interleukin 6 Homo sapiens 302-306 11401420-1 2001 Treatment of MC3T3E-1 osteoblast cultures with combined interferon- gamma(IFN- gamma), lipopolysaccharide (LPS) and tumor necrosis factor- alpha(TNF- alpha) induces expressions of inducible nitric oxide synthase (iNOS) and interleukin-6 (IL-6), resulting in sustained releases of large amounts of nitric oxide and IL-6. Nitric Oxide 190-202 interleukin 6 Homo sapiens 223-236 11401420-1 2001 Treatment of MC3T3E-1 osteoblast cultures with combined interferon- gamma(IFN- gamma), lipopolysaccharide (LPS) and tumor necrosis factor- alpha(TNF- alpha) induces expressions of inducible nitric oxide synthase (iNOS) and interleukin-6 (IL-6), resulting in sustained releases of large amounts of nitric oxide and IL-6. Nitric Oxide 190-202 interleukin 6 Homo sapiens 238-242 11401420-1 2001 Treatment of MC3T3E-1 osteoblast cultures with combined interferon- gamma(IFN- gamma), lipopolysaccharide (LPS) and tumor necrosis factor- alpha(TNF- alpha) induces expressions of inducible nitric oxide synthase (iNOS) and interleukin-6 (IL-6), resulting in sustained releases of large amounts of nitric oxide and IL-6. Nitric Oxide 190-202 interleukin 6 Homo sapiens 314-318 11050099-0 2001 Recombinant human interleukins IL-1alpha, IL-1beta, IL-4, IL-6, and IL-7 show different and specific calcium-independent carbohydrate-binding properties. Calcium 101-108 interleukin 6 Homo sapiens 58-62 11285373-8 2001 CONCLUSION: DEX may suppress the production of inflammatory cytokines, such as IL-6 and IL-1beta, but it neither prevents the translocation of NF-kappaB to the nucleus nor induces the synthesis of IkappaB-alpha protein in FLSs stimulated by TNF-alpha. Dexamethasone 12-15 interleukin 6 Homo sapiens 79-83 11050099-0 2001 Recombinant human interleukins IL-1alpha, IL-1beta, IL-4, IL-6, and IL-7 show different and specific calcium-independent carbohydrate-binding properties. Carbohydrates 121-133 interleukin 6 Homo sapiens 58-62 11314001-3 2001 This investigation reports that IL-6 protected cells against apoptosis induced by a variety of agents including, TGF-beta, UV and retinoic acid (RA) in Hep3B cells, suggesting that IL-6 is a fundamental determinant of hepatic cell survival. Tretinoin 130-143 interleukin 6 Homo sapiens 32-36 11161456-0 2001 Chemioxyexcitation (delta pO2/ROS)-dependent release of IL-1 beta, IL-6 and TNF-alpha: evidence of cytokines as oxygen-sensitive mediators in the alveolar epithelium. Reactive Oxygen Species 30-33 interleukin 6 Homo sapiens 67-71 11314001-3 2001 This investigation reports that IL-6 protected cells against apoptosis induced by a variety of agents including, TGF-beta, UV and retinoic acid (RA) in Hep3B cells, suggesting that IL-6 is a fundamental determinant of hepatic cell survival. Tretinoin 130-143 interleukin 6 Homo sapiens 181-185 11314001-3 2001 This investigation reports that IL-6 protected cells against apoptosis induced by a variety of agents including, TGF-beta, UV and retinoic acid (RA) in Hep3B cells, suggesting that IL-6 is a fundamental determinant of hepatic cell survival. Tretinoin 145-147 interleukin 6 Homo sapiens 32-36 11314001-3 2001 This investigation reports that IL-6 protected cells against apoptosis induced by a variety of agents including, TGF-beta, UV and retinoic acid (RA) in Hep3B cells, suggesting that IL-6 is a fundamental determinant of hepatic cell survival. Tretinoin 145-147 interleukin 6 Homo sapiens 181-185 11223651-1 2001 The in vitro effect of ibuprofen (IB) on the production of the proinflammatory cytokines interleukin (IL) 1beta, IL-6, and tumor necrosis factor alpha (TNF-alpha) and the anti-inflammatory cytokine IL-10 by cord blood mononuclear cells from preterm newborns was compared to that of peripheral blood mononuclear cells of adults. Ibuprofen 34-36 interleukin 6 Homo sapiens 113-117 11233994-1 2001 In the hope of identifying agents of therapeutic value in glomerulonephritis from Chinese herbs, we found that methanolic extracts of Polygonum hypoleucum Ohwi (P. hypoleucum Ohwi) inhibit human mesangial cells proliferation activated with interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) previously. methanolic 111-121 interleukin 6 Homo sapiens 273-286 11233994-1 2001 In the hope of identifying agents of therapeutic value in glomerulonephritis from Chinese herbs, we found that methanolic extracts of Polygonum hypoleucum Ohwi (P. hypoleucum Ohwi) inhibit human mesangial cells proliferation activated with interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) previously. methanolic 111-121 interleukin 6 Homo sapiens 288-292 11264891-7 2001 The stabilization of the cellular thiol status was followed by an improvement of phagocytosis and the degree of maturation as well as significant changes in the synthesis of IL-6 and IL-1ra. Sulfhydryl Compounds 34-39 interleukin 6 Homo sapiens 174-178 11182374-16 2001 These data suggest that ETOH may contribute to bone loss through activation of signal transduction that results in production of an osteoclastogenic cytokine (i.e., interleukin-6) in osteoblasts. Ethanol 24-28 interleukin 6 Homo sapiens 165-178 11168744-11 2001 The cellular interaction with EMD generates an intracellular cAMP signal, after which cells secrete TGF-beta1, IL-6 and PDGF AB. Cyclic AMP 61-65 interleukin 6 Homo sapiens 111-115 11289656-8 2001 Dexamethasone also inhibited the release of IL-6, IL-8, and PGE2 induced by IL-1beta in both OA and RA fibroblasts. Dexamethasone 0-13 interleukin 6 Homo sapiens 44-48 11251036-6 2001 The infusion of hydrocortisone was associated with significant reductions in serum IL-6 and IL-8 levels and with earlier resolution of the sepsis-induced organ dysfunction syndrome. Hydrocortisone 16-30 interleukin 6 Homo sapiens 83-87 11236942-8 2001 Doxorubicin and melphalan were able to suppress bcl-XL expression only in the presence of IL-6. Doxorubicin 0-11 interleukin 6 Homo sapiens 90-94 11160202-5 2001 On the other hand, ATP markedly and dose-dependently inhibited LPS- and soluble CD40 ligand-dependent production of IL-1alpha, IL-1beta, TNF-alpha, IL-6, and IL-12, whereas IL-1 receptor antagonist and IL-10 production was not affected. Adenosine Triphosphate 19-22 interleukin 6 Homo sapiens 148-152 11236942-5 2001 An interleukin-6-dependent myeloma cell line ANBL6 was used and treated with dexamethasone, doxorubicin, and melphalan in the presence of bone marrow stromal cells. Dexamethasone 77-90 interleukin 6 Homo sapiens 3-16 11288978-6 2001 Amiodarone-induced IL-6 production was inhibited by prednisolone at 10(-7) M. Electron microscopic examination revealed that the thyroid follicles in the suspension culture remained intact at 1 microM, but that cytotoxic effects (decreased microvilli and increased onion-like inclusion bodies) occurred at higher concentrations (10-25 microM). Amiodarone 0-10 interleukin 6 Homo sapiens 19-23 11288978-0 2001 Amiodarone stimulates interleukin-6 production in cultured human thyrocytes, exerting cytotoxic effects on thyroid follicles in suspension culture. Amiodarone 0-10 interleukin 6 Homo sapiens 22-35 11288978-7 2001 These in vitro findings indicate that amiodarone does not impair thyroid function at clinically attainable serum levels (1 microM), but exerts cytotoxic effect by inducing the production of a proinflammatory cytokine (IL-6) at higher concentrations. Amiodarone 38-48 interleukin 6 Homo sapiens 218-222 11288978-1 2001 To investigate whether amiodarone increases interleukin-6 (IL-6) production in thyrocytes, human follicles obtained from subtotally thyroidectomized patients with Graves" disease were cultured in serum-free medium supplemented with various concentrations of bovine thyrotropin (bTSH) and amiodarone. Amiodarone 23-33 interleukin 6 Homo sapiens 44-57 11288978-8 2001 Because amiodarone-induced IL-6 production was inhibited by prednisolone, it is reasonable to administer glucocorticoids to patients with amiodarone-induced destructive thyrotoxicosis (type II). Amiodarone 8-18 interleukin 6 Homo sapiens 27-31 11288978-8 2001 Because amiodarone-induced IL-6 production was inhibited by prednisolone, it is reasonable to administer glucocorticoids to patients with amiodarone-induced destructive thyrotoxicosis (type II). Amiodarone 138-148 interleukin 6 Homo sapiens 27-31 11133502-0 2001 Prostaglandin E(2)-induced interleukin-6 release by a human airway epithelial cell line. Dinoprostone 0-18 interleukin 6 Homo sapiens 27-40 11050083-8 2001 Rac1N17 also inhibited HSF activation by l-azetidine-2-carboxylic acid, a proline analog, and heavy metals (CdCl)), suggesting that Rac1 may be linked to HSF activation by denaturation of polypeptides in response to various proteotoxic stresses. cdcl 108-112 interleukin 6 Homo sapiens 23-26 11050083-8 2001 Rac1N17 also inhibited HSF activation by l-azetidine-2-carboxylic acid, a proline analog, and heavy metals (CdCl)), suggesting that Rac1 may be linked to HSF activation by denaturation of polypeptides in response to various proteotoxic stresses. cdcl 108-112 interleukin 6 Homo sapiens 154-157 11154226-9 2001 IL-6-producing MCCs showed minimal spontaneous and dexamethasone-induced apoptosis, whereas a regular amplitude of apoptosis occurred in the IL-6(-) MCCs. Dexamethasone 51-64 interleukin 6 Homo sapiens 0-4 11154231-7 2001 In the OH-2 and ANBL-6 cell lines and in a patient sample, immunoblotting showed that BMP-4 down-regulated IL-6-induced tyrosine phosphorylation of Stat3, suggesting a mechanism for the apparent antagonism between IL-6 and BMP-4. Tyrosine 120-128 interleukin 6 Homo sapiens 107-111 11133502-9 2001 After PGE(2) treatment, increases in IL-6 mRNA were noted at 4 and 18 h. Therefore, PGE(2) increases airway epithelial cell IL-6 production and release. Dinoprostone 6-12 interleukin 6 Homo sapiens 37-41 11133502-9 2001 After PGE(2) treatment, increases in IL-6 mRNA were noted at 4 and 18 h. Therefore, PGE(2) increases airway epithelial cell IL-6 production and release. Dinoprostone 6-12 interleukin 6 Homo sapiens 124-128 11133502-9 2001 After PGE(2) treatment, increases in IL-6 mRNA were noted at 4 and 18 h. Therefore, PGE(2) increases airway epithelial cell IL-6 production and release. Dinoprostone 6-11 interleukin 6 Homo sapiens 37-41 11133502-9 2001 After PGE(2) treatment, increases in IL-6 mRNA were noted at 4 and 18 h. Therefore, PGE(2) increases airway epithelial cell IL-6 production and release. Dinoprostone 6-11 interleukin 6 Homo sapiens 124-128 11233396-7 2001 There was no correlation between the levels of these cytokines in the serum and the length of cardiopulmonary bypass, although there was a positive relation between levels of interleukin-6 and lactate in samples withdrawn at two hours of the end of bypass, and the measured levels of the cytokines correlated with the extent of inotropic drugs employed in the postoperative period. Lactic Acid 193-200 interleukin 6 Homo sapiens 175-188 11196191-12 2001 On IL-6 stimulation, SHP-2 and Gab1 were recruited to the gp130 subunit of the IL-6 receptor and tyrosine phosphorylated, allowing downstream signaling to the MAPK and PI3K pathways. Tyrosine 97-105 interleukin 6 Homo sapiens 3-7 11196191-12 2001 On IL-6 stimulation, SHP-2 and Gab1 were recruited to the gp130 subunit of the IL-6 receptor and tyrosine phosphorylated, allowing downstream signaling to the MAPK and PI3K pathways. Tyrosine 97-105 interleukin 6 Homo sapiens 79-83 11352498-0 2001 A novel and rapid prediction assay for the effectiveness of IL-6 receptor specific antisense oligonucleotides by proliferation inhibition of an interleukin-6 dependent cell line. Oligonucleotides 93-109 interleukin 6 Homo sapiens 144-157 11352498-3 2001 We attempted to interrupt the signal transducing pathway of IL-6 with the help of antisense oligonucleotides (ASOs) designed against the IL-6R. Oligonucleotides 92-108 interleukin 6 Homo sapiens 60-64 11341305-3 2001 We aimed to investigate the role of IL-6 for the gender-specific changes of acrophase steroid hormone secretion in healthy subjects during aging. Steroids 86-101 interleukin 6 Homo sapiens 36-40 11482910-0 2001 gp130-specific antisense oligonucleotides inhibit IL-6 signal inducing junB mRNA transcription in the human hepatoma cell line, HepG2. Oligonucleotides 25-41 interleukin 6 Homo sapiens 50-54 11394246-1 2001 In the present study we investigated the possibility that exercise-induced increases in plasma levels of interleukin (IL)-6 are associated with plasma lactate levels. Lactic Acid 151-158 interleukin 6 Homo sapiens 105-123 11394246-9 2001 Furthermore, plasma IL-6 was negatively correlated to plasma lactate at rest (r = -0.786, P = 0.05). Lactic Acid 61-68 interleukin 6 Homo sapiens 20-24 11394246-10 2001 Given that IL-6 is a cytokine with growth-promoting potential, the results of this study suggest that high lactate production contributes to the decreased muscle function observed in MM patients by inhibiting the production of IL-6. Lactic Acid 107-114 interleukin 6 Homo sapiens 11-15 11394246-10 2001 Given that IL-6 is a cytokine with growth-promoting potential, the results of this study suggest that high lactate production contributes to the decreased muscle function observed in MM patients by inhibiting the production of IL-6. Lactic Acid 107-114 interleukin 6 Homo sapiens 227-231 11482910-1 2001 The biosynthesis of interleukin-6 receptor (IL-6R) and gp130 in vitro was blocked using specific antisense oligonucleotides (ASO) in HepG2 liver cells and the efficacy of various ASOs was tested on the generation of IL-6-induced junB mRNA. Oligonucleotides 107-123 interleukin 6 Homo sapiens 44-48 11341305-7 2001 After correction for IL-6, the age-related decrease of steroid hormones was blunted in both gender groups except for androstenedione (female and male: p<0.005). Steroids 55-62 interleukin 6 Homo sapiens 21-25 16233144-7 2001 The water-insoluble sample greatly enhanced the growth of the human T cell line (H9) up to 1 x 10(5) with sample supplementation at 1.0 mg/l concentration from 4.3 x 10(4) without sample supplementation as well as improved the secretion level of both IL-6 and TNF-alpha up to 100 pg/ml from approximately 40 pg/ml without sample supplementation. Water 4-9 interleukin 6 Homo sapiens 251-255 11855786-13 2001 Increased production of IL-6 and IL-8 might have contributed to abnormalities in iron metabolism and it is probably due to overstimulation of macrophages. Iron 81-85 interleukin 6 Homo sapiens 24-28 11306983-7 2001 RESULTS: Histamine induced a concentration-dependent release of beta-glucuronidase and IL-6 with a maximum release after 2 and 6 h of incubation, respectively. Histamine 9-18 interleukin 6 Homo sapiens 87-91 11108930-0 2001 Resveratrol inhibits interleukin-6 production in cortical mixed glial cells under hypoxia/hypoglycemia followed by reoxygenation. Resveratrol 0-11 interleukin 6 Homo sapiens 21-34 11211151-8 2001 Biologic effects included induction of low plasma concentrations of tumor necrosis factor-alpha and interleukin-6 observed immediately after MDXH210 infusion and 70% saturation of circulating monocyte-associated Fc gamma RI with MDXH210 at a dose level of 4 to 8 mg/m2. MDX-H210 antibody 141-148 interleukin 6 Homo sapiens 100-113 11108930-7 2001 Among the antioxidants studied, only resveratrol suppressed IL-6 gene expression and protein secretion in mixed glial cultures under hypoxia/hypoglycemia followed by reoxygenation. Resveratrol 37-48 interleukin 6 Homo sapiens 60-64 11887802-0 2001 Interleukin-6 levels decrease in effluent from patients dialyzed with bicarbonate/lactate-based peritoneal dialysis solutions. Bicarbonates 70-81 interleukin 6 Homo sapiens 0-13 11887802-0 2001 Interleukin-6 levels decrease in effluent from patients dialyzed with bicarbonate/lactate-based peritoneal dialysis solutions. Lactic Acid 82-89 interleukin 6 Homo sapiens 0-13 11070335-6 2001 Moreover, DEX reduced the plasma levels of IL-6, TNF-alpha and sTNF-R p75. Dexamethasone 10-13 interleukin 6 Homo sapiens 43-47 11104703-3 2000 Furthermore, IL-1beta selectively down-regulated the IL-6-induced tyrosine phosphorylation of STAT1 without affecting the level of STAT1 or tyrosine phosphorylation of STAT3. Tyrosine 66-74 interleukin 6 Homo sapiens 53-57 11770031-10 2001 Using heparin-coated circuits in group 3 led to IL-10 upregulation (P < 0.05) and IL-6 suppression (P < 0.05). Heparin 6-13 interleukin 6 Homo sapiens 85-89 11770031-12 2001 An inverse relationship was found for IL-10 (IL-6) levels and venous O2 saturation (SvO2), and mean arterial pressure (MAP). Oxygen 69-71 interleukin 6 Homo sapiens 45-49 11847482-0 2001 Influence of reduced nicotinamide adenine dinucleotide on the production of interleukin-6 by peripheral human blood leukocytes. NAD 21-54 interleukin 6 Homo sapiens 76-89 11847482-6 2001 RESULTS: In PBLs from the 18 healthy donors, NADH significantly stimulated the dose-dependent release of IL-6, ranging from 6.25 to 400 microg/ml, compared to medium-treated cells (p < 0.001). NAD 45-49 interleukin 6 Homo sapiens 105-109 11847482-7 2001 An amount of 1,000 pg/ml IL-6 was induced by NADH concentrations ranging from 3.1 to >25 microg/ml. NAD 45-49 interleukin 6 Homo sapiens 25-29 11007619-10 2000 Pentoxifylline potentiated IL-6 and IL-1 production in monocytes exposed to titanium particles and had a biphasic effect on the PGE(2) production. Titanium 76-84 interleukin 6 Homo sapiens 27-31 11113455-5 2000 IL-6-induced activation of signal transducer and activator of transcription 3 (STAT3) activity and STAT3-mediated gene expression were suppressed by 17beta-estradiol (E2) in breast cancer cells. Estradiol 149-165 interleukin 6 Homo sapiens 0-4 11162290-4 2000 Stimulation of macrophages with either CNTFRalpha in combination with CNTF or IL-6 alone resulted in tyrosine phosphorylation of an approximately 130 kD protein, presumed to be gp130. Tyrosine 101-109 interleukin 6 Homo sapiens 78-82 11104733-4 2000 Pretreatment of HASM with prostaglandin (PG) E(2), forskolin, or dibutyryl cAMP inhibited TNF-alpha-induced RANTES secretion but increased TNF-alpha-induced IL-6 secretion. Dinoprostone 26-49 interleukin 6 Homo sapiens 157-161 11104733-4 2000 Pretreatment of HASM with prostaglandin (PG) E(2), forskolin, or dibutyryl cAMP inhibited TNF-alpha-induced RANTES secretion but increased TNF-alpha-induced IL-6 secretion. Cyclic AMP 75-79 interleukin 6 Homo sapiens 157-161 11104733-7 2000 Collectively, these data demonstrate that increasing [cAMP](i) in HASM effectively increases IL-6 secretion but reduces RANTES secretion promoted by TNF-alpha. Cyclic AMP 54-58 interleukin 6 Homo sapiens 93-97 11104733-8 2000 Reverse transcriptase/polymerase chain reaction and ribonuclease protection assays suggested that these opposite effects of increased [cAMP](i) on TNF-alpha- induced IL-6 and RANTES secretion may occur at the transcriptional level. Cyclic AMP 135-139 interleukin 6 Homo sapiens 166-170 11104733-13 2000 Together, our data suggest that TNF-alpha-induced IL-6 and RANTES secretion may be associated with NF-kappaB activation, and that inhibition of TNF-alpha-stimulated RANTES secretion and augmentation of IL-6 secretion by increased [cAMP](i) in HASM cells occurs via an NF-kappaB-independent mechanism. Cyclic AMP 231-235 interleukin 6 Homo sapiens 202-206 11007619-7 2000 In contrast to ciprofloxacin, indomethacin was not a potent inhibitor of TNF-alpha production but potentiated IL-6 production in titanium-stimulated monocytes. Titanium 129-137 interleukin 6 Homo sapiens 110-114 11125296-8 2000 Interleukin-6 (IL-6) is known to be an essential survival factor of myeloma cells and to protect them from apoptosis induced by different stimuli (e.g. dexamethasone, CD95, serum starvation, gamma-irradiation). Dexamethasone 152-165 interleukin 6 Homo sapiens 0-13 11125296-8 2000 Interleukin-6 (IL-6) is known to be an essential survival factor of myeloma cells and to protect them from apoptosis induced by different stimuli (e.g. dexamethasone, CD95, serum starvation, gamma-irradiation). Dexamethasone 152-165 interleukin 6 Homo sapiens 15-19 11281377-3 2000 In vitro, in primary cultures of adrenal gland cells, chronic exposure to IL-6 stimulates adrenocortical steroid release in a time- and dose-dependent manner. Steroids 105-112 interleukin 6 Homo sapiens 74-78 11024008-6 2000 C5b-9 also induced formation of reactive oxygen species, which, along with IL-6 release, was inhibited by the antioxidant N-acetylcysteine. Reactive Oxygen Species 32-55 interleukin 6 Homo sapiens 75-79 11024008-6 2000 C5b-9 also induced formation of reactive oxygen species, which, along with IL-6 release, was inhibited by the antioxidant N-acetylcysteine. Acetylcysteine 122-138 interleukin 6 Homo sapiens 75-79 11024008-7 2000 C5b-9 activated the redox-sensitive transcription factors NF-kB and activator protein-1 (AP-1), which were both involved in the induction of IL-6 by C5b-9, as demonstrated by cis element double-stranded (decoy) oligonucleotides (ODN). Oligonucleotides 211-227 interleukin 6 Homo sapiens 141-145 11080198-8 2000 Electrical field stimulation markedly reduced IL-6 secretion, which was attenuated by the NPY Y1 receptor antagonist BIBP 3226 (10(-7) M, p = 0.039; 10(-8) M, p = 0.035). bibp 117-121 interleukin 6 Homo sapiens 46-50 11225716-2 2000 Inflammatory mediators such as tumor necrosis factor-alpha and interleukin-6 (IL-6) may have a direct effect on glucose and lipid metabolism. Glucose 112-119 interleukin 6 Homo sapiens 63-76 11225716-2 2000 Inflammatory mediators such as tumor necrosis factor-alpha and interleukin-6 (IL-6) may have a direct effect on glucose and lipid metabolism. Glucose 112-119 interleukin 6 Homo sapiens 78-82 11225716-4 2000 The aim of this study was to examine the relationship between IL-6 levels in healthy volunteers (control group) and three different groups of obese patients: patients without obstructive sleep apnea syndrome (OSAS), patients with OSAS, and patients with obesity hypoventilation syndrome (OHS) (daytime baseline oxygen saturation of <93%). Oxygen 311-317 interleukin 6 Homo sapiens 62-66 11067924-2 2000 In the case of human IL-6, this binding is displaceable by soluble heparin, IC(50) approximately 2 microg/ml, corresponding to approximately 200 nM. Heparin 67-74 interleukin 6 Homo sapiens 21-25 11084220-4 2000 The results show that noradrenaline, 10(-5) M, significantly suppressed the production of IL-6; noradrenaline, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA and TNF alpha; clonidine, 10(-5) M, significantly suppressed the production of TNF alpha; and yohimbine, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA. Norepinephrine 22-35 interleukin 6 Homo sapiens 90-94 11084220-4 2000 The results show that noradrenaline, 10(-5) M, significantly suppressed the production of IL-6; noradrenaline, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA and TNF alpha; clonidine, 10(-5) M, significantly suppressed the production of TNF alpha; and yohimbine, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA. Norepinephrine 96-109 interleukin 6 Homo sapiens 90-94 11084220-5 2000 It is concluded that (1) noradrenaline has significant negative immunoregulatory effects in humans through suppression of the production of (monocytic) proinflammatory cytokines, e.g. IL-6 and TNF alpha, and (2) the suppression of the production of TNF alpha may be related to alpha(2)-adrenoceptor-related mechanisms. Norepinephrine 25-38 interleukin 6 Homo sapiens 184-188 11067924-5 2000 The epitopes of five IL-6-specific mAbs were still accessible in heparin-bound IL-6, and the dimer formed from the association of rIL-6 with its truncated soluble receptor polypeptide, srIL-6alpha, still bound to heparin. Heparin 65-72 interleukin 6 Homo sapiens 21-25 11067924-5 2000 The epitopes of five IL-6-specific mAbs were still accessible in heparin-bound IL-6, and the dimer formed from the association of rIL-6 with its truncated soluble receptor polypeptide, srIL-6alpha, still bound to heparin. Heparin 65-72 interleukin 6 Homo sapiens 79-83 11067924-5 2000 The epitopes of five IL-6-specific mAbs were still accessible in heparin-bound IL-6, and the dimer formed from the association of rIL-6 with its truncated soluble receptor polypeptide, srIL-6alpha, still bound to heparin. Heparin 213-220 interleukin 6 Homo sapiens 21-25 11067924-6 2000 Further analysis showed that heparin competed partially and weakly with the binding of srIL-6 to IL-6; however, it competed strongly for the binding of the rIL-6/srIL-6Ralpha dimer, to soluble glycoprotein 130. Heparin 29-36 interleukin 6 Homo sapiens 89-93 11067924-8 2000 By contrast, heparin was able to protect IL-6 from digestion by the bacterial endoproteinase Lys-C. Heparin 13-20 interleukin 6 Homo sapiens 41-45 11067924-10 2000 This interaction will tend to retain IL-6 close to its sites of secretion in the tissues by binding to heparin-like glycosaminoglycans, thus favoring a paracrine mode of activity. Heparin 103-110 interleukin 6 Homo sapiens 37-41 11053033-3 2000 Triptolide, with an IC(50) of approximately 20-50 ng/ml, inhibits normal and transformed human bronchial epithelial cell expression of interleukin (IL)-6 and IL-8 stimulated by phorbol 12-myristate 13-acetate (PMA), tumor necrosis factor-alpha, or IL-1 beta. Tetradecanoylphorbol Acetate 177-208 interleukin 6 Homo sapiens 135-153 10952983-5 2000 Moreover, direct suppression of intracellular ROS levels by antioxidants decreases stress-stimulated HSF activity. Reactive Oxygen Species 46-49 interleukin 6 Homo sapiens 101-104 11076827-0 2000 Serotonin increases interleukin-6 synthesis in human vascular smooth muscle cells. Serotonin 0-9 interleukin 6 Homo sapiens 20-33 11076827-8 2000 The effect of 5-HT on IL-6 production was significantly inhibited by the 5-HT(2) receptor antagonist ketanserin and the selective 5-HT(2A) receptor antagonist sarpogrelate. Ketanserin 101-111 interleukin 6 Homo sapiens 22-26 11053033-3 2000 Triptolide, with an IC(50) of approximately 20-50 ng/ml, inhibits normal and transformed human bronchial epithelial cell expression of interleukin (IL)-6 and IL-8 stimulated by phorbol 12-myristate 13-acetate (PMA), tumor necrosis factor-alpha, or IL-1 beta. Tetradecanoylphorbol Acetate 210-213 interleukin 6 Homo sapiens 135-153 11050000-7 2000 ANBL6 is an IL-6-dependent cell line that is sensitive to dexamethasone (Dex), Dox, and Mel. Dexamethasone 58-71 interleukin 6 Homo sapiens 12-16 11050000-7 2000 ANBL6 is an IL-6-dependent cell line that is sensitive to dexamethasone (Dex), Dox, and Mel. Dexamethasone 73-76 interleukin 6 Homo sapiens 12-16 11050000-7 2000 ANBL6 is an IL-6-dependent cell line that is sensitive to dexamethasone (Dex), Dox, and Mel. Doxorubicin 79-82 interleukin 6 Homo sapiens 12-16 11050000-8 2000 IL-6 is able to protect ANBL6 cells from Dex- and Mel- but not Dox-induced apoptosis. Doxorubicin 63-66 interleukin 6 Homo sapiens 0-4 11071255-2 2000 Water contaminated with inflammatory substances induced the pro-inflammatory hormone interleukin 6 (IL-6). Water 0-5 interleukin 6 Homo sapiens 85-98 11138340-1 2000 OBJECTIVE: In view of the importance of estrogen and IL-6 in the pathogenesis of rheumatoid arthritis (RA), the effects of 17 beta-estradiol (E2) on interleukin (IL)-6 production in cultured rheumatoid fibroblast-like synoviocytes were investigated. Estradiol 123-140 interleukin 6 Homo sapiens 149-167 10951379-0 2000 Combined effect of titanium particles and TNF-alpha on the production of IL-6 by osteoblast-like cells. Titanium 19-27 interleukin 6 Homo sapiens 73-77 10951379-3 2000 On the other hand, production of interleukin-6, which is well known to induce osteoclastogenesis and to directly stimulate bone resorption, was additively stimulated by the combination of TNF-alpha and titanium particles. Titanium 202-210 interleukin 6 Homo sapiens 33-46 10951379-4 2000 These results suggest that the association of TNF-alpha and titanium particles may play an important role in the pathogenesis of periprosthetic osteolysis through two different pathways: a reduced periprosthetic bone formation due to inhibition of osteoblast proliferation and alkaline phosphatase production, and osteoblast-mediated activation of osteoclastic bone resorption as suggested by the enhancement of interleukin-6 production. Titanium 60-68 interleukin 6 Homo sapiens 412-425 11046056-4 2000 IL-1, TNF-alpha, and LPS blocked the activation of Stat DNA binding and tyrosine phosphorylation by IL-6 and IL-10, but not by IFN-gamma, in primary macrophages. Tyrosine 72-80 interleukin 6 Homo sapiens 100-104 11071255-2 2000 Water contaminated with inflammatory substances induced the pro-inflammatory hormone interleukin 6 (IL-6). Water 0-5 interleukin 6 Homo sapiens 100-104 11071255-3 2000 All water samples collected from the Eerste River, Stellenbosch, induced IL-6 secretion, and the quantity of IL-6 secreted is dependent on the concentration and origin of the sample. Water 4-9 interleukin 6 Homo sapiens 73-77 11048965-4 2000 The anti-inflammatory drug, dexamethasone (1 microM), abolished the production of both IL-6 and IL-8 in gingival fibroblasts challenged with PHT in the presence or absence of IL-1beta. Dexamethasone 28-41 interleukin 6 Homo sapiens 87-91 10975857-2 2000 We evaluated the role of NF-kappaB in HRV-16-induced IL-8 and IL-6 production by EMSA using oligonucleotides corresponding to the binding sites for NF-kappaB in the IL-6 and IL-8 gene promoters. Oligonucleotides 92-108 interleukin 6 Homo sapiens 165-169 11079743-9 2000 RESULTS: We show that cells grown in a medium with high glucose concentration underwent great ATP-mediated morphological changes, enhanced apoptosis, caspase 3 activation and interleukin-6 release. Glucose 56-63 interleukin 6 Homo sapiens 175-188 11121687-9 2000 It is concluded that indomethacin may reduce the thrombin-induced inflammatory reaction by decreasing IL-6 through inhibition of PGE2 synthesis. Dinoprostone 129-133 interleukin 6 Homo sapiens 102-106 11075897-12 2000 A comparison of these membrane groups showed that only the pre-WBS IL-6 concentration in the hemophane group was elevated (p=0.022) after dialysis. Hemophan 93-102 interleukin 6 Homo sapiens 67-71 11061532-3 2000 For this purpose, dexamethasone inhibition of lipopolysaccharide-induced interleukin-6 and tumor necrosis factor-alpha production in peripheral leukocytes, beclomethasone dipropionate-induced skin blanching, and suppression of cortisol levels after low-dose (0.5 mg) dexamethasone suppression test were determined in each subject. Dexamethasone 18-31 interleukin 6 Homo sapiens 73-118 11069732-13 2000 As previously reported, the inhibition of NO synthesis by the competitive inhibitor L-NMMA led to enhancement of IL-6, IL-8 and PGE(2)production by IL-1 beta treated chondrocytes, but did not significantly modify IL-10, PG and MMP-3 productions. omega-N-Methylarginine 84-90 interleukin 6 Homo sapiens 113-117 11056211-2 2000 Galiellalactone inhibits the IL-6-induced SEAP expression with IC(50) values of 250-500 nM by blocking the binding of the activated Stat3 dimers to their DNA binding sites without inhibiting the tyrosine and serine phosphorylation of the Stat3 transcription factor. Serine 208-214 interleukin 6 Homo sapiens 29-33 11143760-6 2000 Finally, studies of variants of newer candidates, such as the mitochondrial genome, LMNA, and IL-6, indicate that many different genes might be important determinants of plasma triglyceride concentration in the general population. Triglycerides 177-189 interleukin 6 Homo sapiens 94-98 11034109-1 2000 The report shows that melatonin enhances IL-2 and IL-6 production by two human lymphocytic (Jurkat) and monocytic (U937) cell lines via a nuclear receptor-mediated mechanism. Melatonin 22-31 interleukin 6 Homo sapiens 50-54 11034109-9 2000 However, in U937 cells activated with IFN-gamma, which induces the expression of the RORgamma1 and RORalpha2 nuclear receptors and represses the expression of the mt1 receptor, melatonin can activate IL-6 production. Melatonin 177-186 interleukin 6 Homo sapiens 200-204 10982829-5 2000 Our results indicate that the coiled-coil domain is essential for Stat3 recruitment to the receptor and the subsequent tyrosine phosphorylation and tyrosine phosphorylation-dependent activities, such as dimer formation, nuclear translocation, and DNA binding, stimulated by epidermal growth factor (EGF) or interleukin-6 (IL-6). Tyrosine 119-127 interleukin 6 Homo sapiens 307-320 10982829-5 2000 Our results indicate that the coiled-coil domain is essential for Stat3 recruitment to the receptor and the subsequent tyrosine phosphorylation and tyrosine phosphorylation-dependent activities, such as dimer formation, nuclear translocation, and DNA binding, stimulated by epidermal growth factor (EGF) or interleukin-6 (IL-6). Tyrosine 119-127 interleukin 6 Homo sapiens 322-326 10982829-5 2000 Our results indicate that the coiled-coil domain is essential for Stat3 recruitment to the receptor and the subsequent tyrosine phosphorylation and tyrosine phosphorylation-dependent activities, such as dimer formation, nuclear translocation, and DNA binding, stimulated by epidermal growth factor (EGF) or interleukin-6 (IL-6). Tyrosine 148-156 interleukin 6 Homo sapiens 307-320 10982829-5 2000 Our results indicate that the coiled-coil domain is essential for Stat3 recruitment to the receptor and the subsequent tyrosine phosphorylation and tyrosine phosphorylation-dependent activities, such as dimer formation, nuclear translocation, and DNA binding, stimulated by epidermal growth factor (EGF) or interleukin-6 (IL-6). Tyrosine 148-156 interleukin 6 Homo sapiens 322-326 11027495-6 2000 Studies on the mode of action revealed that CPDHC (1) affects the IL-6-dependent pathway by inhibiting the tyrosine phosphorylation of the STAT3 and STAT1 as well as the serine phosphorylation of the Stat3 transcription factor. Tyrosine 107-115 interleukin 6 Homo sapiens 66-70 11027495-6 2000 Studies on the mode of action revealed that CPDHC (1) affects the IL-6-dependent pathway by inhibiting the tyrosine phosphorylation of the STAT3 and STAT1 as well as the serine phosphorylation of the Stat3 transcription factor. Serine 170-176 interleukin 6 Homo sapiens 66-70 10975857-3 2000 Consistent with the rapid induction of mRNA for IL-8 and IL-6, maximal NF-kappaB binding to both oligonucleotides was detected at 30 min after infection. Oligonucleotides 97-113 interleukin 6 Homo sapiens 57-61 10975857-5 2000 The IL-8 oligonucleotide bound recombinant p50 with only about one-tenth the efficiency of the IL-6 oligonucleotide, even though epithelial cells produced more IL-8 protein than IL-6. Oligonucleotides 9-24 interleukin 6 Homo sapiens 178-182 10880077-10 2000 Challenge with titanium particles at concentrations of 0.075%, 0.150%, 0.300%, and 0.600% vol/vol increased the release of interleukin-6 by 2.6-, 6.4-, 9.6-, and 10. Titanium 15-23 interleukin 6 Homo sapiens 123-136 10880077-0 2000 G-protein activity requirement for polymethylmethacrylate and titanium particle-induced fibroblast interleukin-6 and monocyte chemoattractant protein-1 release in vitro. Titanium 62-70 interleukin 6 Homo sapiens 99-112 10880077-7 2000 Exposure of fibroblasts to titanium and polymethylmethacrylate (PMMA) particles resulted in a dose-dependent release of MCP-1 and IL-6. Titanium 27-35 interleukin 6 Homo sapiens 130-134 10880513-0 2000 SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells. Dexamethasone 61-74 interleukin 6 Homo sapiens 39-52 10880513-1 2000 Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cells, blocks both RAFTK activation and apoptosis induced by Dex. Dexamethasone 137-150 interleukin 6 Homo sapiens 221-234 10880513-1 2000 Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cells, blocks both RAFTK activation and apoptosis induced by Dex. Dexamethasone 137-150 interleukin 6 Homo sapiens 236-240 10880513-1 2000 Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cells, blocks both RAFTK activation and apoptosis induced by Dex. Dexamethasone 152-155 interleukin 6 Homo sapiens 221-234 10880513-1 2000 Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cells, blocks both RAFTK activation and apoptosis induced by Dex. Dexamethasone 152-155 interleukin 6 Homo sapiens 236-240 10880513-1 2000 Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cells, blocks both RAFTK activation and apoptosis induced by Dex. Dexamethasone 346-349 interleukin 6 Homo sapiens 221-234 10880513-1 2000 Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cells, blocks both RAFTK activation and apoptosis induced by Dex. Dexamethasone 346-349 interleukin 6 Homo sapiens 236-240 10880513-2 2000 However, the mechanism whereby IL-6 inhibits Dex-induced apoptosis is undefined. Dexamethasone 45-48 interleukin 6 Homo sapiens 31-35 10880513-4 2000 We show that IL-6 triggers selective activation of SHP2 and its association with RAFTK in Dex-treated MM cells. Dexamethasone 90-93 interleukin 6 Homo sapiens 13-17 10880513-7 2000 Moreover, overexpression of dominant negative SHP2 blocked the protective effect of IL-6 against Dex-induced apoptosis. Dexamethasone 97-100 interleukin 6 Homo sapiens 84-88 10880077-15 2000 Titanium particle induced fibroblast IL-6 release was inhibited by 48.2% and 56.3% with 20- and 200-ng/mL doses of pertussis toxin, respectively. Titanium 0-8 interleukin 6 Homo sapiens 37-41 10976010-2 2000 The present study was aimed to evaluate the influence of both acute alcohol abstinence (in alcoholics) and acute alcohol intake (in healthy subjects) on serum IL-6, IL-8, IL-10, and IL-12 levels. Alcohols 68-75 interleukin 6 Homo sapiens 159-163 11000287-7 2000 Analysis of DC supernatants after treatment with PG demonstrated significantly higher amounts of the proinflammatory cytokines IL-1 beta, IL-6, TNF-alpha, and IL-12. Prostaglandins 49-51 interleukin 6 Homo sapiens 138-142 10925306-4 2000 Antioxidants including NAC, glutathione, and catalase reduced TGF-beta1-induced IL-6 gene expression, and direct H2O2 treatment induced IL-6 expression in a dose-dependent manner. Glutathione 28-39 interleukin 6 Homo sapiens 80-84 10946280-8 2000 Interestingly, one SHP2-recruiting phosphotyrosine motif in a single chain of the gp130 dimer is sufficient to mediate SHP2 association to the gp130 receptor subunit and its tyrosine phosphorylation as well as to attenuate IL-6-dependent gene induction. Tyrosine 42-50 interleukin 6 Homo sapiens 223-227 11028659-8 2000 Furthermore, PD98059 or SB203580 significantly suppressed BK-induced IL-6 and IL-8 production and their gene expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 interleukin 6 Homo sapiens 69-73 10925306-4 2000 Antioxidants including NAC, glutathione, and catalase reduced TGF-beta1-induced IL-6 gene expression, and direct H2O2 treatment induced IL-6 expression in a dose-dependent manner. Hydrogen Peroxide 113-117 interleukin 6 Homo sapiens 136-140 10925306-7 2000 EGTA suppressed TGF-beta1- or H2O2-induced IL-6 expression, and ionomycin increased IL-6 expression, with simultaneously modulating AP-1 activity in the same pattern. Egtazic Acid 0-4 interleukin 6 Homo sapiens 43-47 10925306-7 2000 EGTA suppressed TGF-beta1- or H2O2-induced IL-6 expression, and ionomycin increased IL-6 expression, with simultaneously modulating AP-1 activity in the same pattern. Hydrogen Peroxide 30-34 interleukin 6 Homo sapiens 43-47 10925306-7 2000 EGTA suppressed TGF-beta1- or H2O2-induced IL-6 expression, and ionomycin increased IL-6 expression, with simultaneously modulating AP-1 activity in the same pattern. Ionomycin 64-73 interleukin 6 Homo sapiens 84-88 10925306-8 2000 PD98059, an inhibitor of mitogen-activated protein kinase (MAPK) kinase/extracellular signal-related kinase kinase 1, suppressed TGF-beta1- or H2O2-induced IL-6 and AP-1 activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 interleukin 6 Homo sapiens 156-160 10958925-2 2000 In this context interleukin-2 (IL-2), interleukin-6 (IL-6) and thymoma are crucial because both involved in MG pathogenesis and correlated with acetylcholine receptors (AchRs) Ab production. Acetylcholine 144-157 interleukin 6 Homo sapiens 38-51 10925306-8 2000 PD98059, an inhibitor of mitogen-activated protein kinase (MAPK) kinase/extracellular signal-related kinase kinase 1, suppressed TGF-beta1- or H2O2-induced IL-6 and AP-1 activation. Hydrogen Peroxide 143-147 interleukin 6 Homo sapiens 156-160 10958925-2 2000 In this context interleukin-2 (IL-2), interleukin-6 (IL-6) and thymoma are crucial because both involved in MG pathogenesis and correlated with acetylcholine receptors (AchRs) Ab production. Acetylcholine 144-157 interleukin 6 Homo sapiens 53-57 10925306-9 2000 In addition, TGF-beta1 or H2O2 increased MAPK activity which was reduced by EGTA and NAC, suggesting that MAPK is involved in TGF-beta1-induced IL-6 expression. Hydrogen Peroxide 26-30 interleukin 6 Homo sapiens 144-148 10925306-9 2000 In addition, TGF-beta1 or H2O2 increased MAPK activity which was reduced by EGTA and NAC, suggesting that MAPK is involved in TGF-beta1-induced IL-6 expression. Egtazic Acid 76-80 interleukin 6 Homo sapiens 144-148 10925306-10 2000 Taken together, these results indicate that TGF-beta1 induces a transient increase of intracellular H2O2 production, which regulates downstream events such as Ca2+ influx, MAPK, and AP-1 activation and IL-6 gene expression. Hydrogen Peroxide 100-104 interleukin 6 Homo sapiens 202-206 10928984-6 2000 Coincubation with OPC cell lines with conditioned medium from a TPA-exposed HL-60 cells stimulated growth proportional to the IL-6 levels measured in the conditioned medium. Tetradecanoylphorbol Acetate 64-67 interleukin 6 Homo sapiens 126-130 10945640-7 2000 IFN-alpha as well as IL-6 prevented DEX plus alphaIGF-1R-induced apoptosis, and this prevention was blocked by the mitogen-activated protein kinase kinase inhibitor, PD098059, or the phosphatidylinositol 3-kinase inhibitor, wortmannin. Dexamethasone 36-39 interleukin 6 Homo sapiens 21-25 10945640-7 2000 IFN-alpha as well as IL-6 prevented DEX plus alphaIGF-1R-induced apoptosis, and this prevention was blocked by the mitogen-activated protein kinase kinase inhibitor, PD098059, or the phosphatidylinositol 3-kinase inhibitor, wortmannin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 166-174 interleukin 6 Homo sapiens 21-25 10945640-8 2000 Therefore, both IL-6 and IFN-alpha blocked DEX plus alphaIGF-1R-induced apoptosis through activation of the mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways. Dexamethasone 43-46 interleukin 6 Homo sapiens 16-20 10919979-4 2000 These cells produced LBP in response to interleukin (IL)-1beta, IL-6, and tumor necrosis factor- alpha, a response that was strongly enhanced by dexamethasone. Dexamethasone 145-158 interleukin 6 Homo sapiens 64-102 10920220-0 2000 Induction of interleukin-6 release in human osteoblast-like cells exposed to titanium particles in vitro. Titanium 77-85 interleukin 6 Homo sapiens 13-26 10920220-3 2000 This study showed that exposure of MG-63 osteoblast-like cells to titanium particles at a concentration of 0.30% v/v resulted in a 15-fold increase in IL-6 release into the culture medium after 24 hours, when compared with cells without particles. Titanium 66-74 interleukin 6 Homo sapiens 151-155 10920220-4 2000 Northern blots revealed that exposure of MG-63 cells to titanium particles at a concentration of 0.30% v/v for 24 hours increased IL-6 mRNA signal levels by 9.6-fold, when compared with control cultures. Titanium 56-64 interleukin 6 Homo sapiens 130-134 10920220-9 2000 This study showed that osteoblast-like cells respond to titanium particles through increased expression of the proinflammatory cytokine, IL-6, in a process requiring phagocytosis and intracellular signaling pathways. Titanium 56-64 interleukin 6 Homo sapiens 137-141 10946899-10 2000 Moreover, all-trans-retinoic acid increased the mRNA expression of thyroglobulin and decreased both the mRNA expression and secretion of interleukin-6 and leukemia inhibitory factor while significantly stimulating growth. Tretinoin 10-33 interleukin 6 Homo sapiens 137-150 10922477-1 2000 Prior activation of mitogen-activated protein kinases by phorbol 13-myristate 12-acetate (PMA) results in an inhibition of interleukin (IL)-6-induced activation of the Janus kinase/signal transducer and activator of transcription (STAT) signaling pathway which is most likely mediated by the induction of suppressor of cytokine signaling-3 and requires the specific SHP2 binding site Y759 of the IL-6 signal transducer gp130. Tetradecanoylphorbol Acetate 90-93 interleukin 6 Homo sapiens 123-141 10922477-1 2000 Prior activation of mitogen-activated protein kinases by phorbol 13-myristate 12-acetate (PMA) results in an inhibition of interleukin (IL)-6-induced activation of the Janus kinase/signal transducer and activator of transcription (STAT) signaling pathway which is most likely mediated by the induction of suppressor of cytokine signaling-3 and requires the specific SHP2 binding site Y759 of the IL-6 signal transducer gp130. Tetradecanoylphorbol Acetate 90-93 interleukin 6 Homo sapiens 396-400 10922477-2 2000 In this study, we demonstrate that PMA inhibits STAT activation by IL-6 and the related cytokine leukemia inhibitory factor (LIF) but not by oncostatin M (OSM). Tetradecanoylphorbol Acetate 35-38 interleukin 6 Homo sapiens 67-71 10884313-4 2000 Pretreatment of astrocytes with P2 receptor antagonists, including suramin and periodate oxidized ATP (oATP), resulted in a significant downregulation of IL-1beta-stimulated expression of nitric oxide, tumor necrosis factor (TNFalpha), and IL-6 at both the protein and mRNA levels, without affecting cell viability. Adenosine Triphosphate 98-101 interleukin 6 Homo sapiens 240-244 10873157-5 2000 Expression of IL-6 and IL-8 was sensitive to SB203580, the specific inhibitor of p38 mitogen-activated protein (MAP) kinase and PD98059, an inhibitor of MAP kinase kinase. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 128-135 interleukin 6 Homo sapiens 14-18 11091023-16 2000 Among the cytokines, IL-1beta, IL-6, and TNFalpha were the predominant cytokines affected by chronic use of alcohol during pregnancy. Alcohols 108-115 interleukin 6 Homo sapiens 31-35 11091023-20 2000 We conclude that chronic alcohol use during pregnancy stimulated the fetal cytokine synthesis and secretion, and IL-1beta, IL-6, and TNF alpha were the predominant cytokines affected by alcohol. Alcohols 186-193 interleukin 6 Homo sapiens 123-127 10928765-0 2000 Interleukin-6 levels in the conjunctival epithelium of patients with dry eye disease treated with cyclosporine ophthalmic emulsion. Cyclosporine 98-110 interleukin 6 Homo sapiens 0-13 10873159-7 2000 Release of IL-6 elicited by TNF-alpha was significantly inhibited by dexamethasone, cycloheximide, and nordihydroguaiaretic acid (NDGA). Dexamethasone 69-82 interleukin 6 Homo sapiens 11-15 10861141-9 2000 However, expression of TNF-alpha and IL-8, IFN-gamma, and IL-6 and IL-1beta was 2-20 times greater in patients administered 100% than in those administered 30% oxygen. Oxygen 160-166 interleukin 6 Homo sapiens 58-62 10928765-7 2000 IL-6 normalized for G3PDH (IL-6/G3PDH ratio) was not different from baseline at 3 months but showed a significant decrease from baseline in the group treated with 0.05% CsA (p = 0.048) at 6 months. Cyclosporine 169-172 interleukin 6 Homo sapiens 0-4 10928765-7 2000 IL-6 normalized for G3PDH (IL-6/G3PDH ratio) was not different from baseline at 3 months but showed a significant decrease from baseline in the group treated with 0.05% CsA (p = 0.048) at 6 months. Cyclosporine 169-172 interleukin 6 Homo sapiens 27-31 10928765-9 2000 CONCLUSIONS: This preliminary, small-cohort study showed a decrease in IL-6 in the conjunctival epithelium of moderate to severe dry eye patients treated with 0.05% CsA for 6 months. Cyclosporine 165-168 interleukin 6 Homo sapiens 71-75 10929062-1 2000 This work examines the correlation between serum levels of oestrogen, progesterone and dehydroepiandrosterone sulphate (DHEA-S) and the number of human peripheral blood cells actively secreting interleukin (IL)-2, IL-4, IL-6, IL-10, tumour necrosis factor-alpha (TNF-alpha) or interferon-gamma (IFN-gamma) in vivo. Dehydroepiandrosterone Sulfate 87-118 interleukin 6 Homo sapiens 220-224 10880263-11 2000 The IL-6 signal pathway is mediated through PTK, NF-kappaB, and also involve PKC, intracellular calcium and sensitive to dexamethasone, but is not related to PKA, G-protein and IL-10. Calcium 96-103 interleukin 6 Homo sapiens 4-8 10880263-11 2000 The IL-6 signal pathway is mediated through PTK, NF-kappaB, and also involve PKC, intracellular calcium and sensitive to dexamethasone, but is not related to PKA, G-protein and IL-10. Dexamethasone 121-134 interleukin 6 Homo sapiens 4-8 10880268-9 2000 There were slightly higher TNF-alpha and IL-6 levels after the operation and significantly lower cortisol levels during the operation in the regional anaesthesia group compared to the general anaesthesia group, giving rise to a significant inverse correlation between peak values of IL-6 and peak values of cortisol. Hydrocortisone 97-105 interleukin 6 Homo sapiens 283-287 10880268-9 2000 There were slightly higher TNF-alpha and IL-6 levels after the operation and significantly lower cortisol levels during the operation in the regional anaesthesia group compared to the general anaesthesia group, giving rise to a significant inverse correlation between peak values of IL-6 and peak values of cortisol. Hydrocortisone 307-315 interleukin 6 Homo sapiens 283-287 10816606-0 2000 Adenosine-induced expression of interleukin-6 in astrocytes through protein kinase A and NF-IL-6. Adenosine 0-9 interleukin 6 Homo sapiens 32-45 10816606-2 2000 The expression of IL-6 in astrocytes is stimulated by extracellular adenosine through A(2B) receptors. Adenosine 68-77 interleukin 6 Homo sapiens 18-22 10816606-4 2000 Expression of PKI, an inhibitor of protein kinase A (PKA), interfered with IL-6 transcription indicating that PKA mediates the effect of adenosine. Adenosine 137-146 interleukin 6 Homo sapiens 75-79 10816606-5 2000 The CAAT box of the IL-6 promoter is necessary for the stimulation by adenosine as a mutation in this element reduced the stimulation by adenosine. Adenosine 70-79 interleukin 6 Homo sapiens 20-24 10816606-5 2000 The CAAT box of the IL-6 promoter is necessary for the stimulation by adenosine as a mutation in this element reduced the stimulation by adenosine. Adenosine 137-146 interleukin 6 Homo sapiens 20-24 10816606-6 2000 Indeed, the cAMP agonist forskolin increased the binding of the transcription factors NF-IL-6 and C/EBPdelta to the CAAT box of the IL-6 promoter in nuclear extracts of astrocytes. Cyclic AMP 12-16 interleukin 6 Homo sapiens 89-93 10816606-7 2000 Inhibition of the de novo synthesis of NF-IL-6 by cycloheximide or an antisense oligonucleotide reduced the enhancement of NF-IL-6 binding to the CAAT box and inhibited stimulation of IL-6 transcription by forskolin. Oligonucleotides 80-95 interleukin 6 Homo sapiens 42-46 10816606-9 2000 This suggests that adenosine induces the de novo synthesis of NF-IL-6 through activation of PKA and thereby stimulates transcription of IL-6 in astrocytes. Adenosine 19-28 interleukin 6 Homo sapiens 65-69 10880259-2 2000 When stable HBD-FGF-2 HeLa cell lines were transiently transfected with an interleukin 6 (IL-6) construct, the IL-6 promoter activity was downregulated by the addition of oestradiol. Estradiol 171-181 interleukin 6 Homo sapiens 75-88 10880259-2 2000 When stable HBD-FGF-2 HeLa cell lines were transiently transfected with an interleukin 6 (IL-6) construct, the IL-6 promoter activity was downregulated by the addition of oestradiol. Estradiol 171-181 interleukin 6 Homo sapiens 90-94 10880259-2 2000 When stable HBD-FGF-2 HeLa cell lines were transiently transfected with an interleukin 6 (IL-6) construct, the IL-6 promoter activity was downregulated by the addition of oestradiol. Estradiol 171-181 interleukin 6 Homo sapiens 111-115 10880263-5 2000 Phorbol-12-myristate-13-acetate (PMA), calcium ionophore A23187, TNF-alpha, IL-1beta, oncostatin M (OSM) but not lipopolysaccharide stimulated IL-6 production from gastric epithelial cell line MKN-28. Tetradecanoylphorbol Acetate 0-31 interleukin 6 Homo sapiens 143-147 10940869-6 2000 Furthermore, Dex-DC showed a decreased CD40 ligand-induced IL-6 and TNF-alpha production, a complete block in IL-12p40 production, while IL-10 production was unaffected. dex-dc 13-19 interleukin 6 Homo sapiens 59-63 10924750-5 2000 Although the precise mechanism for chorioamnionitis-driven preterm labor mediated via cytokines is still unknown, both IL-1 and TNF-alpha along with IL-6 enhance prostaglandin production by human amnion cells, chorionic cells and decidual cells. Prostaglandins 162-175 interleukin 6 Homo sapiens 149-153 10882695-2 2000 Grepafloxacin 1-30 mg/L inhibited the production of interleukin 1alpha (IL-1alpha) and IL-1beta, and the expression of IL-1alpha, IL-1beta, tumour necrosis factor alpha (TNFalpha), IL-6 and IL-8 mRNA. grepafloxacin 0-13 interleukin 6 Homo sapiens 181-185 10878544-5 2000 IL-6 receptor immunostaining was evaluated in 21 paraffin-embedded prostate tumour specimens. Paraffin 49-57 interleukin 6 Homo sapiens 0-4 10834930-3 2000 We now demonstrate that epinephrine as well as norepinephrine can induce IL-6 in an endothelial cell line (HMEC-1). Norepinephrine 47-61 interleukin 6 Homo sapiens 73-77 10886590-12 2000 CONCLUSIONS: These results suggest an important role for poor dialysis biocompatibility of CU on the release of sIL-6R, which increases sIL-6R plasma levels, thereby enhancing the inflammatory effects of IL-6. Copper 91-93 interleukin 6 Homo sapiens 113-117 10886221-0 2000 A combination of anti-interleukin 6 murine monoclonal antibody with dexamethasone and high-dose melphalan induces high complete response rates in advanced multiple myeloma. Dexamethasone 68-81 interleukin 6 Homo sapiens 22-35 10843763-4 2000 Dexamethasone increased the expression of the membrane IL-6R and endogenous sIL6R release, and increased responses to supramaximal but not submaximal IL-6 concentrations. Dexamethasone 0-13 interleukin 6 Homo sapiens 55-59 10824125-7 2000 In the Limulus amebocyte lysate assay, the triacyl lipid A is more than 105-fold less active than hexa-acyl lipid A, but only 10-fold less active in inducing IL-6 in human mononuclear cells, and equally active in inducing NO production in murine macrophages. defoslimod 43-58 interleukin 6 Homo sapiens 158-162 10764798-0 2000 The inhibition of interleukin-6-dependent STAT activation by mitogen-activated protein kinases depends on tyrosine 759 in the cytoplasmic tail of glycoprotein 130. Tyrosine 106-114 interleukin 6 Homo sapiens 18-31 10764798-1 2000 Mitogen-activated protein (MAP) kinases stimulated by phorbol 13-myristate 12-acetate (PMA) have been shown to inhibit interleukin-6-induced activation of STAT3 (Sengupta, T. K., Talbot, E. S., Scherle, P. A., and Ivashkiv, L. B. Tetradecanoylphorbol Acetate 87-90 interleukin 6 Homo sapiens 119-132 10925209-5 2000 The thiol antioxidant, N-acetylcysteine (NAC) abolished the synergism between IL-1beta or IL-6 and 1,25(OH)(2)D(3), but had only a small protective effect when the cytokines acted alone. Sulfhydryl Compounds 4-9 interleukin 6 Homo sapiens 90-100 10821876-1 2000 Data from animal and in vitro studies suggest that the growth-promoting effects of the adrenal androgen dehydroepiandrosterone sulfate (DHEAS) may be mediated by stimulation of insulin-like growth factor-I (IGF-I) and/or inhibition of interleukin 6 (IL-6), a cytokine mediator of bone resorption. Dehydroepiandrosterone Sulfate 104-134 interleukin 6 Homo sapiens 235-248 10821876-1 2000 Data from animal and in vitro studies suggest that the growth-promoting effects of the adrenal androgen dehydroepiandrosterone sulfate (DHEAS) may be mediated by stimulation of insulin-like growth factor-I (IGF-I) and/or inhibition of interleukin 6 (IL-6), a cytokine mediator of bone resorption. Dehydroepiandrosterone Sulfate 104-134 interleukin 6 Homo sapiens 250-254 10844583-5 2000 Postoperatively, on the day of surgery, ACTH and cortisol concentrations in group 1 patients were positively correlated to the blood concentrations of IL-1beta, IL-6 and TNF-alpha. Hydrocortisone 49-57 interleukin 6 Homo sapiens 161-165 10844583-8 2000 In the early postoperative period, cytokines appear to be involved in the activation of the HPA axis, while in the later postoperative period, high cortisol concentrations may inhibit the release of IL-6. Hydrocortisone 148-156 interleukin 6 Homo sapiens 199-203 10875461-10 2000 Oxygen-derived free radicals and many cytokines (e.g., interleukin [IL]-1, IL-6, IL-8, tumor necrosis factor-alpha, platelet activating factor) are considered to be principal mediators in the transformation of acute pancreatitis from a local inflammatory process into a multiorgan illness. Oxygen 0-6 interleukin 6 Homo sapiens 75-79 10925209-5 2000 The thiol antioxidant, N-acetylcysteine (NAC) abolished the synergism between IL-1beta or IL-6 and 1,25(OH)(2)D(3), but had only a small protective effect when the cytokines acted alone. Acetylcysteine 23-39 interleukin 6 Homo sapiens 90-100 10847629-7 2000 Tyrosine phosphorylation of both Stat5a and Stat5b was induced by IL-6. Tyrosine 0-8 interleukin 6 Homo sapiens 66-70 10888707-0 2000 The adrenal steroid status in relation to inflammatory cytokines (interleukin-6 and tumour necrosis factor) in polymyalgia rheumatica. Steroids 12-19 interleukin 6 Homo sapiens 66-79 10888707-4 2000 In PMR patients, serum levels of IL-6 were positively correlated with serum levels of ASD (P < 0.001), cortisol (P < 0.001), and DHEAS (P = 0. Hydrocortisone 106-114 interleukin 6 Homo sapiens 33-37 10847630-4 2000 EMSAs demonstrated that AdiNOS inhibits IL-6-induced Stat3 activation and that this inhibition is reversible in the presence of the NOS inhibitor N(G)-monomethyl-L-arginine (L-NMA). omega-N-Methylarginine 146-172 interleukin 6 Homo sapiens 40-44 10847630-0 2000 Induced nitric oxide inhibits IL-6-induced stat3 activation and type II acute phase mRNA expression. Nitric Oxide 8-20 interleukin 6 Homo sapiens 30-34 10847630-2 2000 We tested the hypothesis that iNOS-derived nitric oxide (NO) attenuates the acute phase response by inhibiting IL-6-enhanced Stat3 DNA-binding activity and type II acute phase mRNA expression. Nitric Oxide 43-55 interleukin 6 Homo sapiens 111-115 10832617-0 2000 Mineral and/or metal content as critical determinants of particle-induced release of IL-6 and IL-8 from A549 cells. Metals 15-20 interleukin 6 Homo sapiens 85-89 10839541-7 2000 Acetylcholine, the principle vagal neurotransmitter, significantly attenuated the release of cytokines (tumour necrosis factor (TNF), interleukin (IL)-1beta, IL-6 and IL-18), but not the anti-inflammatory cytokine IL-10, in lipopolysaccharide-stimulated human macrophage cultures. Acetylcholine 0-13 interleukin 6 Homo sapiens 158-162 10881828-5 2000 RESULTS: Dexamethasone caused an eightfold decrease in interleukin-6 levels and a greater than threefold decrease in tumor necrosis factor-alpha levels after CPB (p < 0.05). Dexamethasone 9-22 interleukin 6 Homo sapiens 55-68 10952025-7 2000 Significant reduced serum levels of IL-4 and IL-6 derived from Th2 cells and IgE were observed in the patients treated with YH-Tang. yh-tang 124-131 interleukin 6 Homo sapiens 45-49 10899704-0 2000 Nuclear receptors are involved in the enhanced IL-6 production by melatonin in U937 cells. Melatonin 66-75 interleukin 6 Homo sapiens 47-51 10899704-1 2000 This report shows that melatonin enhances IL-6 production by U937 cells via a nuclear receptor-mediated mechanism. Melatonin 23-32 interleukin 6 Homo sapiens 42-46 10899704-4 2000 However, in U937 cells activated with IFN-gamma, which induces the expression of the ROR alpha 1 and ROR alpha 2 nuclear receptors and represses the expression of the mt1 receptor, melatonin can activate IL-6 production. Melatonin 181-190 interleukin 6 Homo sapiens 204-208 10785230-0 2000 Retinoic acid suppresses interleukin-6 production in human endometrial cells. Tretinoin 0-13 interleukin 6 Homo sapiens 25-38 10785230-1 2000 OBJECTIVE: To determine whether retinoic acid (RA) can regulate the expression of interleukin (IL)-6 in human endometrial cells in a manner that might be beneficial to women with endometriosis. Tretinoin 32-45 interleukin 6 Homo sapiens 82-100 10785230-1 2000 OBJECTIVE: To determine whether retinoic acid (RA) can regulate the expression of interleukin (IL)-6 in human endometrial cells in a manner that might be beneficial to women with endometriosis. Tretinoin 47-49 interleukin 6 Homo sapiens 82-100 10785230-7 2000 RESULT(S): Using a human endometrial cell line (EM42), as well as primary stromal and epithelial endometrial cells, we demonstrated that RA suppresses IL-6 protein and messenger RNA expression in a time- and dose-dependent fashion, showing maximal effects at pharmacologically achievable blood serum concentrations (micromoles per liter). Tretinoin 137-139 interleukin 6 Homo sapiens 151-155 10785230-8 2000 Retinoic acid specifically inhibited the activity of IL-6-promoter reporter constructs that were transiently transfected into EM42 cells. Tretinoin 0-13 interleukin 6 Homo sapiens 53-57 10785230-9 2000 Mutational analysis of reporter constructs indicated that RA suppression of IL-6 expression was mediated, at least in part, through the nuclear factor IL-6 binding site located in the IL-6 promoter. Tretinoin 58-60 interleukin 6 Homo sapiens 76-80 10785230-9 2000 Mutational analysis of reporter constructs indicated that RA suppression of IL-6 expression was mediated, at least in part, through the nuclear factor IL-6 binding site located in the IL-6 promoter. Tretinoin 58-60 interleukin 6 Homo sapiens 151-155 10785230-9 2000 Mutational analysis of reporter constructs indicated that RA suppression of IL-6 expression was mediated, at least in part, through the nuclear factor IL-6 binding site located in the IL-6 promoter. Tretinoin 58-60 interleukin 6 Homo sapiens 151-155 10810294-0 2000 Stimulation of endogenous GH and interleukin-6 receptors selectively activates different Jaks and Stats, with a Stat5 specific synergistic effect of dexamethasone. Dexamethasone 149-162 interleukin 6 Homo sapiens 33-46 10810294-13 2000 Thus, our studies suggest that while each cytokine, GH and IL-6, may activate various members of the Jak-Stat pathway in overexpression studies, specific activation of Stat3 by IL-6 and of Jak2 and Stat5 by GH can be observed in HEK293 cells and that in this system the synergistic effect of dexamethasone appears specific for Stat5. Dexamethasone 292-305 interleukin 6 Homo sapiens 59-63 10833370-5 2000 IL-6 transcription and secretion were dose-dependently enhanced by stimulation with IL-1beta, tumour necrosis factor (TNF)-alpha, transforming growth factor (TGF)-beta1 and 12-O-tetradecanoyl phorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 173-210 interleukin 6 Homo sapiens 0-4 10830783-0 2000 Induction of chromosomal aberrations and growth-transformation of lymphoblastoid cell lines by inhibition of reactive oxygen species-induced apoptosis with interleukin-6. Reactive Oxygen Species 109-132 interleukin 6 Homo sapiens 156-169 10833370-5 2000 IL-6 transcription and secretion were dose-dependently enhanced by stimulation with IL-1beta, tumour necrosis factor (TNF)-alpha, transforming growth factor (TGF)-beta1 and 12-O-tetradecanoyl phorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 212-215 interleukin 6 Homo sapiens 0-4 10833370-7 2000 The TNF-alpha-induced secretion of IL-6 was inhibited by dexamethasone. Dexamethasone 57-70 interleukin 6 Homo sapiens 35-39 10833370-8 2000 The TPA-induced production of IL-6 was inhibited by 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine and sphyngosine, suggesting the involvement of a protein kinase C-dependent pathway. Tetradecanoylphorbol Acetate 4-7 interleukin 6 Homo sapiens 30-34 10833370-8 2000 The TPA-induced production of IL-6 was inhibited by 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine and sphyngosine, suggesting the involvement of a protein kinase C-dependent pathway. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 52-98 interleukin 6 Homo sapiens 30-34 10798594-0 2000 Decreased natural killer cell responses and altered interleukin-6 and interleukin-10 production in alcoholism: an interaction between alcohol dependence and African-American ethnicity. Alcohols 99-106 interleukin 6 Homo sapiens 52-65 10777583-6 2000 Furthermore, we show that tyrosine 759 in gp130 is essential for both SHP2 and SOCS3 but not for SOCS1 to exert their inhibitory activities on interleukin-6 signal transduction. Tyrosine 26-34 interleukin 6 Homo sapiens 143-156 10798594-9 2000 Regression analyses showed that alcohol dependence and ethnicity predicted NK activity, whereas the interaction between alcohol dependence and ethnicity predicted levels of IL-6 and IL-10. Alcohols 120-127 interleukin 6 Homo sapiens 173-177 10727406-1 2000 In the present study, signal transducer and activator of transcription 3 (STAT3) Ser(727) phosphorylation and transactivation was investigated in relation to activation of mitogen-activated protein (MAP) kinase family members including extracellular-signal-regulated protein kinase (ERK)-1, c-Jun N-terminal kinase (JNK)-1 and p38 ("reactivating kinase") in response to interleukin (IL)-6 stimulation. Serine 81-84 interleukin 6 Homo sapiens 370-388 10727406-4 2000 However, SEK-1/MKK-4 [where SEK-1 stands for stress-activated protein kinase (SAPK)/ERK kinase 1, and MKK-4 stands for MAP kinase kinase 4] was activated in response to IL-6 and overexpression of dominant-negative SEK-1/MKK-4(A-L) reduced both IL-6-induced STAT3 Ser(727) phosphorylation as well as STAT3 transactivation. Serine 263-266 interleukin 6 Homo sapiens 169-173 10727406-7 2000 In conclusion, these data indicate that IL-6-induced STAT3 transactivation and Ser(727) phosphorylation is independent of ERK-1 or JNK-1 activity, but involves a gp130 receptor-signalling cascade that includes Vav, Rac-1, MEKK and SEK-1/MKK-4 as signal transduction components. Serine 79-82 interleukin 6 Homo sapiens 40-44 10863963-0 2000 Adenosine regulates the production of interleukin-6 by human gingival fibroblasts via cyclic AMP/protein kinase A pathway. Adenosine 0-9 interleukin 6 Homo sapiens 38-51 10755407-1 2000 Interleukin 6 (IL-6) is secreted by breast tumours and shows synergistic activity with 17beta-oestradiol (E2), leading to increases in reductive 17beta-hydroxysteroid dehydrogenase activity in breast cancer epithelial cells. Estradiol 87-104 interleukin 6 Homo sapiens 0-13 10755407-1 2000 Interleukin 6 (IL-6) is secreted by breast tumours and shows synergistic activity with 17beta-oestradiol (E2), leading to increases in reductive 17beta-hydroxysteroid dehydrogenase activity in breast cancer epithelial cells. Estradiol 87-104 interleukin 6 Homo sapiens 15-19 10755407-1 2000 Interleukin 6 (IL-6) is secreted by breast tumours and shows synergistic activity with 17beta-oestradiol (E2), leading to increases in reductive 17beta-hydroxysteroid dehydrogenase activity in breast cancer epithelial cells. Estradiol 106-108 interleukin 6 Homo sapiens 0-13 10755407-1 2000 Interleukin 6 (IL-6) is secreted by breast tumours and shows synergistic activity with 17beta-oestradiol (E2), leading to increases in reductive 17beta-hydroxysteroid dehydrogenase activity in breast cancer epithelial cells. Estradiol 106-108 interleukin 6 Homo sapiens 15-19 10708808-0 2000 Methotrexate suppresses the interleukin-6 induced generation of reactive oxygen species in the synoviocytes of rheumatoid arthritis. Reactive Oxygen Species 64-87 interleukin 6 Homo sapiens 28-41 10708808-6 2000 Also, IL-6 stimulated the proliferation of FLSs, and this IL-6 driven proliferation was inhibited with the treatment of MTX or N-acetylcysteine (NAC, 1 mM). Acetylcysteine 127-143 interleukin 6 Homo sapiens 6-10 10708808-6 2000 Also, IL-6 stimulated the proliferation of FLSs, and this IL-6 driven proliferation was inhibited with the treatment of MTX or N-acetylcysteine (NAC, 1 mM). Acetylcysteine 127-143 interleukin 6 Homo sapiens 58-62 10708808-6 2000 Also, IL-6 stimulated the proliferation of FLSs, and this IL-6 driven proliferation was inhibited with the treatment of MTX or N-acetylcysteine (NAC, 1 mM). Acetylcysteine 145-148 interleukin 6 Homo sapiens 6-10 10708808-6 2000 Also, IL-6 stimulated the proliferation of FLSs, and this IL-6 driven proliferation was inhibited with the treatment of MTX or N-acetylcysteine (NAC, 1 mM). Acetylcysteine 145-148 interleukin 6 Homo sapiens 58-62 10708808-7 2000 Furthermore, ROS production in FLSs was increased significantly by IL-6, and its effect was also abrogated in the presence of MTX or NAC. Reactive Oxygen Species 13-16 interleukin 6 Homo sapiens 67-71 10708808-7 2000 Furthermore, ROS production in FLSs was increased significantly by IL-6, and its effect was also abrogated in the presence of MTX or NAC. Acetylcysteine 133-136 interleukin 6 Homo sapiens 67-71 10708808-8 2000 These results suggest that inflammatory reaction in the synovium of RA patients could be augmented by the autocrine or other cytokine-induced production of IL-6 with subsequent generation of ROS in the synoviocytes, and the modulations of IL-6 synthesis and ROS production may contribute to the therapeutic effects of MTX for RA. Reactive Oxygen Species 191-194 interleukin 6 Homo sapiens 156-160 10708808-8 2000 These results suggest that inflammatory reaction in the synovium of RA patients could be augmented by the autocrine or other cytokine-induced production of IL-6 with subsequent generation of ROS in the synoviocytes, and the modulations of IL-6 synthesis and ROS production may contribute to the therapeutic effects of MTX for RA. Reactive Oxygen Species 258-261 interleukin 6 Homo sapiens 156-160 10708808-8 2000 These results suggest that inflammatory reaction in the synovium of RA patients could be augmented by the autocrine or other cytokine-induced production of IL-6 with subsequent generation of ROS in the synoviocytes, and the modulations of IL-6 synthesis and ROS production may contribute to the therapeutic effects of MTX for RA. Reactive Oxygen Species 258-261 interleukin 6 Homo sapiens 239-243 10722595-4 2000 Both the fever and the increased levels of IL-1, TNF, IFN-gamma, IL-2, and IL-6 in supernatant fluids obtained from the SEA-stimulated PBMC were decreased by incubating SEA-PBMC with anisomycin (a protein synthesis inhibitor), aminoguanidine (an inhibitor of inducible nitric oxide synthase [NOS]), or dexamethasone (an inhibitor of NOS). Anisomycin 183-193 interleukin 6 Homo sapiens 75-79 10722595-4 2000 Both the fever and the increased levels of IL-1, TNF, IFN-gamma, IL-2, and IL-6 in supernatant fluids obtained from the SEA-stimulated PBMC were decreased by incubating SEA-PBMC with anisomycin (a protein synthesis inhibitor), aminoguanidine (an inhibitor of inducible nitric oxide synthase [NOS]), or dexamethasone (an inhibitor of NOS). Dexamethasone 302-315 interleukin 6 Homo sapiens 75-79 10863963-6 2000 Interestingly, these cAMP-arising reagents and the permeable cAMP analogue, dibutyryl cAMP (dbtcAMP), also increased IL-6 production by HGF. Cyclic AMP 21-25 interleukin 6 Homo sapiens 117-121 10863963-6 2000 Interestingly, these cAMP-arising reagents and the permeable cAMP analogue, dibutyryl cAMP (dbtcAMP), also increased IL-6 production by HGF. Cyclic AMP 61-65 interleukin 6 Homo sapiens 117-121 10863963-7 2000 These results suggest that cAMP is involved in adenosine-induced IL-6 production by HGF. Cyclic AMP 27-31 interleukin 6 Homo sapiens 65-69 10863963-7 2000 These results suggest that cAMP is involved in adenosine-induced IL-6 production by HGF. Adenosine 47-56 interleukin 6 Homo sapiens 65-69 10863963-8 2000 Adenosine-induced IL-6 production was suppressed by protein kinase A (PKA) inhibitor, H89, indicating that cAMP/PKA pathway is involved in the induction. Adenosine 0-9 interleukin 6 Homo sapiens 18-22 10863963-8 2000 Adenosine-induced IL-6 production was suppressed by protein kinase A (PKA) inhibitor, H89, indicating that cAMP/PKA pathway is involved in the induction. Cyclic AMP 107-111 interleukin 6 Homo sapiens 18-22 10863963-9 2000 Moreover, the experiments using antagonists specific for adenosine receptor subtypes revealed that the adenosine-induced IL-6 production by HGF was, at least in part, mediated by the adenosine A2b receptor. Adenosine 57-66 interleukin 6 Homo sapiens 121-125 10826501-8 2000 Moreover, the antioxidant pyrrolidine dithiocarbamate (10 microM) inhibited ET-1-induced IL-6 release indicating involvement of reactive oxygen species in ET-1 signaling. Reactive Oxygen Species 128-151 interleukin 6 Homo sapiens 89-93 10826501-9 2000 ET-1-stimulated IL-6 secretion was also suppressed by diphenylene iodonium (40 microM), an inhibitor of flavon-containing enzymes such as NADH/NADPH oxidase. flavone 104-110 interleukin 6 Homo sapiens 16-20 10805226-5 2000 In premenopausal females the concentration of estradiol in plasma correlated with the release of TNF-alpha and IL-6 during the luteal phase. Estradiol 46-55 interleukin 6 Homo sapiens 111-115 10832659-8 2000 RESULTS: IL 6 and IL 10 release was significantly less (p<0.05) in the heparin-coated group. Heparin 74-81 interleukin 6 Homo sapiens 9-13 10832659-10 2000 CONCLUSIONS: These results suggest that with the use of heparin-coated circuits there is a lower production of IL 6 and IL 10 from isolated PBMC than with uncoated circuits. Heparin 56-63 interleukin 6 Homo sapiens 111-115 10863963-4 2000 Ligation of adenosine receptors with adenosine or its related analogue, 2-chloroadenosine (2-CADO), increased IL-6 production by HGF without any other stimuli. Adenosine 12-21 interleukin 6 Homo sapiens 110-114 10868978-3 2000 Subjects homozygous for the C allele at position -174 of the IL-6 gene (SfaNI genotype), associated to lower plasma IL-6 levels, showed significantly lower integrated area under the curve of serum glucose concentrations (AUCglucose) after an oral glucose tolerance test, lower blood glycosylated hemoglobin, lower fasting insulin levels, lower total and differential white blood cell count (a putative marker of peripheral IL-6 action), and an increased insulin sensitivity index than carriers of the G allele, despite similar age and body composition. Glucose 197-204 interleukin 6 Homo sapiens 61-65 10729217-7 2000 In contrast, beta-estradiol and testosterone increased LPS-induced IL-6 secretion in six of seven time points during the MC (significant for testosterone, p = .005). Estradiol 13-27 interleukin 6 Homo sapiens 67-71 10729217-7 2000 In contrast, beta-estradiol and testosterone increased LPS-induced IL-6 secretion in six of seven time points during the MC (significant for testosterone, p = .005). Testosterone 32-44 interleukin 6 Homo sapiens 67-71 10729217-7 2000 In contrast, beta-estradiol and testosterone increased LPS-induced IL-6 secretion in six of seven time points during the MC (significant for testosterone, p = .005). Testosterone 141-153 interleukin 6 Homo sapiens 67-71 10704257-0 2000 Retinoic acid suppresses interleukin 6 production in normal human osteoblasts. Tretinoin 0-13 interleukin 6 Homo sapiens 25-38 10704257-9 2000 Within 24 h, RA at all four concentrations reduced Il-6 production from normal human osteoblasts. Tretinoin 13-15 interleukin 6 Homo sapiens 51-55 10704257-10 2000 The pharmacological concentration of 10(-5) M RA suppressed 90% of IL-6 production. Tretinoin 46-48 interleukin 6 Homo sapiens 67-71 10704257-11 2000 The present study shows for the first time that RA profoundly inhibits IL-6 production in normal human osteoblasts within 24 h and in a dose-dependent manner. Tretinoin 48-50 interleukin 6 Homo sapiens 71-75 10704257-12 2000 RA was shown previously to inhibit IL-6 production in several other normal and malignant human cell types. Tretinoin 0-2 interleukin 6 Homo sapiens 35-39 10704257-14 2000 Thus, RA inhibition of IL-6 production in normal human osteoblasts may contribute to the bone abnormalities seen after systemic long-term retinoid therapy in some patients. Tretinoin 6-8 interleukin 6 Homo sapiens 23-27 10704258-7 2000 Ouabain induced the production of IL-1alpha, IL-1beta and IL-6, but not of TNF-alpha. Ouabain 0-7 interleukin 6 Homo sapiens 58-62 10742151-3 2000 Furthermore, two different signal transduction pathways were activated by exogenous HSP70: one dependent on CD14 and intracellular calcium, which resulted in increased IL-1beta, IL-6 and TNF-alpha; and the other independent of CD14 but dependent on intracellular calcium, which resulted in an increase in TNF-alpha but not IL-1beta or IL-6. Calcium 131-138 interleukin 6 Homo sapiens 178-182 10741750-3 2000 In the present study, we characterized biological sequelae and signaling cascades triggered by hIL-6 versus vIL-6 in the hIL-6-dependent MH60 and B9 cell lines. vil- 108-112 interleukin 6 Homo sapiens 121-126 10741750-6 2000 On the other hand, antimouse IL-6 receptor (mIL-6R) Ab blocked response to vIL-6, but not that to hIL-6. vil-6 75-80 interleukin 6 Homo sapiens 29-33 10741750-8 2000 Proliferation of these cell lines in response to both hIL-6 and vIL-6 was blocked by PD98059, an inhibitor of MEK1 activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 85-92 interleukin 6 Homo sapiens 54-59 10741750-10 2000 Finally, both hIL-6 and vIL-6 also maintained viability of serum-starved MH60 and B9 cells and blocked dexamethasone-induced apoptosis of MM.1S human myeloma cells. Dexamethasone 103-116 interleukin 6 Homo sapiens 14-19 10868978-3 2000 Subjects homozygous for the C allele at position -174 of the IL-6 gene (SfaNI genotype), associated to lower plasma IL-6 levels, showed significantly lower integrated area under the curve of serum glucose concentrations (AUCglucose) after an oral glucose tolerance test, lower blood glycosylated hemoglobin, lower fasting insulin levels, lower total and differential white blood cell count (a putative marker of peripheral IL-6 action), and an increased insulin sensitivity index than carriers of the G allele, despite similar age and body composition. Glucose 224-231 interleukin 6 Homo sapiens 61-65 10868978-6 2000 In summary, a polymorphism of the IL-6 gene influences the relationship among insulin sensitivity, postload glucose levels, and peripheral white blood cell count. Glucose 108-115 interleukin 6 Homo sapiens 34-38 10698971-9 2000 Oxidative stress (decrease of glutathione by 50%) reduced post-TNF-alpha levels of IL-6 to 14 +/- 3 and IL-8 to 1 +/- 0.2; the rise of ICAM-1 was completely blocked and E-selectin was only doubled. Glutathione 30-41 interleukin 6 Homo sapiens 83-87 12501620-2 2000 The results showed that there were basic production of interleukin-6(IL-6) and tumor necrosis factor-alpha (TNF-alpha) on MC in the control group without LPS, that high-concentration heparin(500 U/ml) increased the effects of LPS on MC, and that low-concentration heparin (5 U/ml) conversely inhibited the effects of LPS on MC. Heparin 183-190 interleukin 6 Homo sapiens 55-68 12501620-3 2000 These data indicate that the low-concentration heparin could inhibit the proliferation of MC and the secrection of IL-6 and TNF-alpha induced by LPS, and hence provide an experimental evidence for administration of heparin in the treatment glomerular disease. Heparin 47-54 interleukin 6 Homo sapiens 115-119 12501620-3 2000 These data indicate that the low-concentration heparin could inhibit the proliferation of MC and the secrection of IL-6 and TNF-alpha induced by LPS, and hence provide an experimental evidence for administration of heparin in the treatment glomerular disease. Heparin 215-222 interleukin 6 Homo sapiens 115-119 12501620-2 2000 The results showed that there were basic production of interleukin-6(IL-6) and tumor necrosis factor-alpha (TNF-alpha) on MC in the control group without LPS, that high-concentration heparin(500 U/ml) increased the effects of LPS on MC, and that low-concentration heparin (5 U/ml) conversely inhibited the effects of LPS on MC. Heparin 183-190 interleukin 6 Homo sapiens 69-73 10720087-1 2000 Several lines of evidence indicate that interleukin-6 (IL-6) is involved not only in the hepatic acute phase response but also in adipose tissue metabolism, lipoprotein lipase activity, and hepatic triglyceride secretion. Triglycerides 198-210 interleukin 6 Homo sapiens 40-53 10823386-3 2000 MAIN RESULTS: Catecholamines (epinephrine, norepinephrine, isoproterenol, and dopamine) in general inhibit tumor necrosis factor-alpha (TNF) production and may enhance interleukin-6 (IL-6) and IL-10 production. Norepinephrine 43-57 interleukin 6 Homo sapiens 168-181 10823386-3 2000 MAIN RESULTS: Catecholamines (epinephrine, norepinephrine, isoproterenol, and dopamine) in general inhibit tumor necrosis factor-alpha (TNF) production and may enhance interleukin-6 (IL-6) and IL-10 production. Dopamine 78-86 interleukin 6 Homo sapiens 168-181 10823386-3 2000 MAIN RESULTS: Catecholamines (epinephrine, norepinephrine, isoproterenol, and dopamine) in general inhibit tumor necrosis factor-alpha (TNF) production and may enhance interleukin-6 (IL-6) and IL-10 production. Dopamine 78-86 interleukin 6 Homo sapiens 183-187 10720087-1 2000 Several lines of evidence indicate that interleukin-6 (IL-6) is involved not only in the hepatic acute phase response but also in adipose tissue metabolism, lipoprotein lipase activity, and hepatic triglyceride secretion. Triglycerides 198-210 interleukin 6 Homo sapiens 55-59 10720087-6 2000 Serum IL-6 levels correlated positively with fasting triglycerides, VLDL-triglycerides, and postload free fatty acids (r = 0.61, 0.65 and 0.60, respectively; P < 0.001) and negatively with high-density lipoprotein-cholesterol (r = -0.42, P < 0.05). Triglycerides 53-66 interleukin 6 Homo sapiens 6-10 10720087-6 2000 Serum IL-6 levels correlated positively with fasting triglycerides, VLDL-triglycerides, and postload free fatty acids (r = 0.61, 0.65 and 0.60, respectively; P < 0.001) and negatively with high-density lipoprotein-cholesterol (r = -0.42, P < 0.05). Triglycerides 73-86 interleukin 6 Homo sapiens 6-10 10692524-5 2000 RESULTS: IL-6 levels were increased significantly at t(180) compared with t(0) (P<0.02) with both CU and CUf. Copper 101-103 interleukin 6 Homo sapiens 9-13 10711865-6 2000 Hydrocortisone (0.05 micromol/L to 50 micromol/L) inhibited cytokine release in a dose-dependent manner with ED50 values of 0.23 micromol/L, 0.19 micromol/L, and 0.10 micromol/L for IL-6, IL-8, and TNF-alpha, respectively. Hydrocortisone 0-14 interleukin 6 Homo sapiens 182-186 10695998-0 2000 IL-6 enhanced the retinoic acid-induced differentiation of human acute promyelocytic leukemia cells. Tretinoin 18-31 interleukin 6 Homo sapiens 0-4 10695998-1 2000 It has been shown that retinoic acid (RA) induced the expression of interleukin-6 (IL-6) in human acute promyelocytic leukemia HL-60 cells. Tretinoin 23-36 interleukin 6 Homo sapiens 68-81 10695998-1 2000 It has been shown that retinoic acid (RA) induced the expression of interleukin-6 (IL-6) in human acute promyelocytic leukemia HL-60 cells. Tretinoin 23-36 interleukin 6 Homo sapiens 83-87 10695998-1 2000 It has been shown that retinoic acid (RA) induced the expression of interleukin-6 (IL-6) in human acute promyelocytic leukemia HL-60 cells. Tretinoin 38-40 interleukin 6 Homo sapiens 68-81 10695998-1 2000 It has been shown that retinoic acid (RA) induced the expression of interleukin-6 (IL-6) in human acute promyelocytic leukemia HL-60 cells. Tretinoin 38-40 interleukin 6 Homo sapiens 83-87 10695998-2 2000 In the present study, we examined the ability of RA to induce the expression of gp130, the signal-transducing receptor component for IL-6, in HL-60 and a RA-supersensitive cell line HL-60/S4. Tretinoin 49-51 interleukin 6 Homo sapiens 133-137 10695998-5 2000 Furthermore, activation of the RA-induced gp130 by exogenous IL-6 potentiated the differentiating effects of RA. Tretinoin 31-33 interleukin 6 Homo sapiens 61-65 10695998-7 2000 Our findings suggest that the differentiating effects of RA may partially be mediated by the up-regulation of IL-6/gp130 signaling in HL-60 and HL-60/S4 cells. Tretinoin 57-59 interleukin 6 Homo sapiens 110-114 10636920-1 2000 The role of signal transducer and activator of transcription (STAT) signaling pathways in the interleukin-6 (IL-6)-induced morphological differentiation of PC12-E2 cells was assessed using wild type and dominant negative mutants of Stat1 and Stat3, containing Tyr --> Phe (YF), Ser --> Ala (SA), and the double mutations (DM), respectively. Tyrosine 260-263 interleukin 6 Homo sapiens 94-107 10774110-0 2000 [Effect of intrafollicular interleukin-6 levels on the secretion of estradiol and progesterone in patients treated with in vitro fertilization and embryo transfer]. Estradiol 68-77 interleukin 6 Homo sapiens 27-40 10774110-0 2000 [Effect of intrafollicular interleukin-6 levels on the secretion of estradiol and progesterone in patients treated with in vitro fertilization and embryo transfer]. Progesterone 82-94 interleukin 6 Homo sapiens 27-40 10774110-1 2000 The objective was to evaluate the relationship between follicular fluid levels of Interleukin-6 (IL-6) and the seric concentrations of estradiol and progesterone during controlled ovarian hyper-stimulation. Estradiol 135-144 interleukin 6 Homo sapiens 82-95 10774110-1 2000 The objective was to evaluate the relationship between follicular fluid levels of Interleukin-6 (IL-6) and the seric concentrations of estradiol and progesterone during controlled ovarian hyper-stimulation. Estradiol 135-144 interleukin 6 Homo sapiens 97-101 10774110-1 2000 The objective was to evaluate the relationship between follicular fluid levels of Interleukin-6 (IL-6) and the seric concentrations of estradiol and progesterone during controlled ovarian hyper-stimulation. Progesterone 149-161 interleukin 6 Homo sapiens 82-95 10774110-1 2000 The objective was to evaluate the relationship between follicular fluid levels of Interleukin-6 (IL-6) and the seric concentrations of estradiol and progesterone during controlled ovarian hyper-stimulation. Progesterone 149-161 interleukin 6 Homo sapiens 97-101 10888268-0 2000 Biosynthesis of interleukin-6, an autocrine growth factor for melanoma, is regulated by melanoma-derived histamine. Histamine 105-114 interleukin 6 Homo sapiens 16-29 10888268-1 2000 Interleukin-6 is an autocrine growth factor in advanced stage melanoma and biosynthesis of IL-6 is increased by histamine in various cell lines. Histamine 112-121 interleukin 6 Homo sapiens 91-95 10888268-2 2000 In our study we analysed the direct relation of histamine and IL-6 synthesis in human melanoma cell lines. Histamine 48-57 interleukin 6 Homo sapiens 62-66 10888268-5 2000 These data indicate that endogenous histamine has a definite role in the regulation of local IL-6, suggesting that histamine and IL-6 could be part of autocrine growth regulation of the tumor. Histamine 36-45 interleukin 6 Homo sapiens 93-97 10888268-5 2000 These data indicate that endogenous histamine has a definite role in the regulation of local IL-6, suggesting that histamine and IL-6 could be part of autocrine growth regulation of the tumor. Histamine 36-45 interleukin 6 Homo sapiens 129-133 10888268-5 2000 These data indicate that endogenous histamine has a definite role in the regulation of local IL-6, suggesting that histamine and IL-6 could be part of autocrine growth regulation of the tumor. Histamine 115-124 interleukin 6 Homo sapiens 93-97 10774110-2 2000 The levels of IL-6 were measured in follicular fluid of 15 patients undergone to in vitro fertilization and embryo transfer and correlated with the values of seric estradiol and progesterone. Progesterone 178-190 interleukin 6 Homo sapiens 14-18 10774110-3 2000 There were a negative correlation between follicular levels of IL-6 and either estradiol and progesterone. Estradiol 79-88 interleukin 6 Homo sapiens 63-67 10774110-3 2000 There were a negative correlation between follicular levels of IL-6 and either estradiol and progesterone. Progesterone 93-105 interleukin 6 Homo sapiens 63-67 10774110-6 2000 According to the reduction of estradiol, there may be a subtle reduction in aromatase action by effect of IL-6 and other cytokines. Estradiol 30-39 interleukin 6 Homo sapiens 106-110 10692080-7 2000 RESULTS: A significant correlation was present between IL-6 and cortisol levels the first two days after stroke (P < 0.05). Hydrocortisone 64-72 interleukin 6 Homo sapiens 55-59 10636920-1 2000 The role of signal transducer and activator of transcription (STAT) signaling pathways in the interleukin-6 (IL-6)-induced morphological differentiation of PC12-E2 cells was assessed using wild type and dominant negative mutants of Stat1 and Stat3, containing Tyr --> Phe (YF), Ser --> Ala (SA), and the double mutations (DM), respectively. Tyrosine 260-263 interleukin 6 Homo sapiens 109-113 10636920-1 2000 The role of signal transducer and activator of transcription (STAT) signaling pathways in the interleukin-6 (IL-6)-induced morphological differentiation of PC12-E2 cells was assessed using wild type and dominant negative mutants of Stat1 and Stat3, containing Tyr --> Phe (YF), Ser --> Ala (SA), and the double mutations (DM), respectively. Serine 281-284 interleukin 6 Homo sapiens 94-107 10636920-1 2000 The role of signal transducer and activator of transcription (STAT) signaling pathways in the interleukin-6 (IL-6)-induced morphological differentiation of PC12-E2 cells was assessed using wild type and dominant negative mutants of Stat1 and Stat3, containing Tyr --> Phe (YF), Ser --> Ala (SA), and the double mutations (DM), respectively. Serine 281-284 interleukin 6 Homo sapiens 109-113 10636920-1 2000 The role of signal transducer and activator of transcription (STAT) signaling pathways in the interleukin-6 (IL-6)-induced morphological differentiation of PC12-E2 cells was assessed using wild type and dominant negative mutants of Stat1 and Stat3, containing Tyr --> Phe (YF), Ser --> Ala (SA), and the double mutations (DM), respectively. Alanine 292-295 interleukin 6 Homo sapiens 94-107 10636920-1 2000 The role of signal transducer and activator of transcription (STAT) signaling pathways in the interleukin-6 (IL-6)-induced morphological differentiation of PC12-E2 cells was assessed using wild type and dominant negative mutants of Stat1 and Stat3, containing Tyr --> Phe (YF), Ser --> Ala (SA), and the double mutations (DM), respectively. Alanine 292-295 interleukin 6 Homo sapiens 109-113 10636920-7 2000 Furthermore, IL-6 induced robust neurite outgrowth in PC12-E2 cells expressing dominant negative forms of RAS or SHC or in cells pretreated with the mitogen-activated protein kinase mitogen-activated protein kinase kinase inhibitor, PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 233-240 interleukin 6 Homo sapiens 13-17 11268388-5 2000 The catecholamines and serotonin also synergistically stimulate IL-6 release in the presence of IL-1 beta. Serotonin 23-32 interleukin 6 Homo sapiens 64-68 10623843-4 2000 A phosphodiester oligonucleotide containing this motif strongly stimulated CD86, CD40, CD54, and MHC class II expression, IL-6 synthesis, and proliferation of primary human B cells. Oligonucleotides 17-32 interleukin 6 Homo sapiens 122-126 10623619-0 2000 Parthenolide inhibits activation of signal transducers and activators of transcription (STATs) induced by cytokines of the IL-6 family. parthenolide 0-12 interleukin 6 Homo sapiens 123-127 10623619-4 2000 Here we show that parthenolide is also an effective inhibitor of IL-6-type cytokines. parthenolide 18-30 interleukin 6 Homo sapiens 65-69 11268388-6 2000 LPC 18:0 synergistically increases IL-6 release in the presence of norepinephrine, and IL-1 beta transiently increases LPC 18:0 formation in C6 cells. Norepinephrine 67-81 interleukin 6 Homo sapiens 35-39 10774463-2 2000 Among several factors that down-regulate IL-6 gene expression are estrogen and testosterone. Testosterone 79-91 interleukin 6 Homo sapiens 41-45 10774463-4 2000 IL-6 is a potent mediator of inflammatory processes, and it has been proposed that the age-associated increase in IL-6 accounts for certain of the phenotypic changes of advanced age, particularly those that resemble chronic inflammatory disease [decreased lean body mass, osteopenia, low-grade anemia, decreased serum albumin and cholesterol, and increased inflammatory proteins such as C-reactive protein (CRP) and serum amyloid A]. Cholesterol 330-341 interleukin 6 Homo sapiens 0-4 10774463-4 2000 IL-6 is a potent mediator of inflammatory processes, and it has been proposed that the age-associated increase in IL-6 accounts for certain of the phenotypic changes of advanced age, particularly those that resemble chronic inflammatory disease [decreased lean body mass, osteopenia, low-grade anemia, decreased serum albumin and cholesterol, and increased inflammatory proteins such as C-reactive protein (CRP) and serum amyloid A]. Cholesterol 330-341 interleukin 6 Homo sapiens 114-118 11029783-6 2000 Our other studies have revealed that 5"-fluorouridine (5"-DFUR) inhibits the growth of KPL-4 tumors and decreases IL-6 levels in both serum and tumor tissues. 5-fluorouridine 37-53 interleukin 6 Homo sapiens 114-118 10807053-0 2000 The contribution of endotoxins present in the respiratory tract to overproduction of nitric oxide associated with impaired interleukin 6 release in bronchoalveolar leukocytes from lung cancer patients. Nitric Oxide 85-97 interleukin 6 Homo sapiens 123-136 10807053-1 2000 The purpose of the study was to assess the relation between the levels of endotoxins circulating in airways of patients with lung cancer and the ability of bronchoalveolar lavage (BAL) leukocytes for ex vivo release of nitric oxide (NO) and interleukin 6 (IL-6) and for in vitro lipopolysaccharide (LPS)-induced production of the mediators. Nitric Oxide 219-231 interleukin 6 Homo sapiens 241-254 10807053-1 2000 The purpose of the study was to assess the relation between the levels of endotoxins circulating in airways of patients with lung cancer and the ability of bronchoalveolar lavage (BAL) leukocytes for ex vivo release of nitric oxide (NO) and interleukin 6 (IL-6) and for in vitro lipopolysaccharide (LPS)-induced production of the mediators. Nitric Oxide 219-231 interleukin 6 Homo sapiens 256-260 10926317-6 2000 We have confirmed previous reports of IL-6 production by corticotroph adenoma cells and in addition, demonstrated for the first time that the synthetic glucocorticoid dexamethasone is a potent suppressor of intratumoral IL-6 production. Dexamethasone 167-180 interleukin 6 Homo sapiens 38-42 10623435-5 2000 Moreover, we have previously demonstrated that 5-fluorouracile (5-FU) resistant HSC require a combination of interleukin 12 (IL-12), IL-6 and SCF for the production of morphologically recognizable clonogenic elements at day 14 in semisolid medium. Fluorouracil 64-68 interleukin 6 Homo sapiens 133-137 10602032-0 2000 Positive and negative regulatory elements contribute to CpG oligonucleotide-mediated regulation of human IL-6 gene expression. Oligonucleotides 60-75 interleukin 6 Homo sapiens 105-109 10602032-1 2000 Oligonucleotides (ODN) expressing immunostimulatory "CpG motifs" activate human RPMI 8226 myeloma cells to secrete IL-6. Oligonucleotides 0-16 interleukin 6 Homo sapiens 115-119 10854139-5 2000 Gemcitabine and to a lesser extent irinotecan inhibited the secretion of the proinflammatory cytokine IL-6 at concentrations of each drug that produced only small decreases in cell viability. Irinotecan 35-45 interleukin 6 Homo sapiens 102-106 10854139-7 2000 Higher doses of gemcitabine and irinotecan caused a surge in IL-6 release and this was not due to release of intracellular stores of IL-6 through lysis of the cells. Irinotecan 32-42 interleukin 6 Homo sapiens 61-65 10854139-8 2000 CONCLUSIONS: These results suggest that irinotecan and gemcitabine are not only more likely to be active against mesothelioma than other new chemotherapy agents but may also produce a palliative effect in nonresponders to these agents by decreasing the secretion of IL-6. Irinotecan 40-50 interleukin 6 Homo sapiens 266-270 10926317-6 2000 We have confirmed previous reports of IL-6 production by corticotroph adenoma cells and in addition, demonstrated for the first time that the synthetic glucocorticoid dexamethasone is a potent suppressor of intratumoral IL-6 production. Dexamethasone 167-180 interleukin 6 Homo sapiens 220-224 11240649-7 2000 In serum, IL-6, IL-8 and MCP-1 decreased with the administration of steroids prior to paclitaxel, and increased in the 24 h after paclitaxel. Steroids 68-76 interleukin 6 Homo sapiens 10-14 10613737-6 2000 [(3)H]Taurocholate ([(3)H]TC) uptake decreased in WIF-B cells exposed to either TNF-alpha (54% of control), IL-1beta (78%), IL-6 (55%) as single additives, or in triple combination (TCC) (43%). Tritium 0-6 interleukin 6 Homo sapiens 124-128 10613737-12 2000 We conclude that macrophages and their ability to secrete the cytokines TNF-alpha, IL-1beta, and IL-6 may be essential in mediating the endotoxin-induced cholestatic effect of decreased hepatocellular bile salt uptake. Bile Acids and Salts 201-210 interleukin 6 Homo sapiens 97-101 11240649-7 2000 In serum, IL-6, IL-8 and MCP-1 decreased with the administration of steroids prior to paclitaxel, and increased in the 24 h after paclitaxel. Paclitaxel 86-96 interleukin 6 Homo sapiens 10-14 11240649-7 2000 In serum, IL-6, IL-8 and MCP-1 decreased with the administration of steroids prior to paclitaxel, and increased in the 24 h after paclitaxel. Paclitaxel 130-140 interleukin 6 Homo sapiens 10-14 11240649-10 2000 Treatment with paclitaxel is associated with an increase in expression of a limited number of cytokines in patients with ovarian cancer, notably IL-6, IL-8 and MCP-1. Paclitaxel 15-25 interleukin 6 Homo sapiens 145-149 11206729-0 2000 Therapeutic use of dopamine and beta-blockers modulates plasma interleukin-6 levels in patients with congestive heart failure. Dopamine 19-27 interleukin 6 Homo sapiens 63-76 11206729-4 2000 After more than 24 h (mean, 34 h) of treatment with a low dose of intravenous dopamine (mean, 2.4 microg/kg/min) in 1 patients with dilated cardiomyopathy and deterioration of CHF, the plasma IL-6 level was increased significantly (30.8 vs. 16.6 pg/ml; p = 0.003) despite the improved hemodynamics. Dopamine 78-86 interleukin 6 Homo sapiens 192-196 11206729-6 2000 Dopamine increases and beta-blockers decrease the plasma IL-6 level in patients with CHF, suggesting that drugs modulating the sympathetic nervous system may alter IL-6 in these patients. Dopamine 0-8 interleukin 6 Homo sapiens 57-61 11206729-6 2000 Dopamine increases and beta-blockers decrease the plasma IL-6 level in patients with CHF, suggesting that drugs modulating the sympathetic nervous system may alter IL-6 in these patients. Dopamine 0-8 interleukin 6 Homo sapiens 164-168 10611258-5 2000 Addition of the NFkappaB inhibitor SN50 (5 microg/ml) to confluent cultures of endometrial epithelial cells inhibited interleukin (IL)-1alpha (10 ng/ml) and tumour necrosis factor alpha (TNFalpha) (10 ng/ml) stimulated IL-6 (P < 0.001 and P < 0.01 respectively) and LIF (P < 0.01 and P < 0.05 respectively) production. SN50 35-39 interleukin 6 Homo sapiens 219-223 11041362-5 2000 ), endothelin, adrenergic beta2-receptor agonists, and some prostaglandins (EP2-receptor agonists and certain TP-receptor agonists) stimulate, while transforming growth factor-beta2, interleukin-6, and cholinergic agonists inhibit melanogenesis and/or growth of UM in vitro. Prostaglandins 60-74 interleukin 6 Homo sapiens 183-196 10840075-7 2000 IL-6 has been implicated in the inhibitory effect of RA in several human hemopoietic and nonhemopoietic cells. Tretinoin 53-55 interleukin 6 Homo sapiens 0-4 10657766-7 2000 CONCLUSION: TCA exerts a toxic effect on keratinocytes and fibroblasts while GA does not alter the metabolism of fibroblasts but induces the secretion of IL-6. glycolic acid 77-79 interleukin 6 Homo sapiens 154-158 10579793-6 2000 RESULTS: Tyrosine phosphorylation of p85 is upregulated by IL-6 in both LNCaP and PC-3. Tyrosine 9-17 interleukin 6 Homo sapiens 59-63 10816058-0 2000 Heparin-coated cardiopulmonary bypass circuits reduce circulating complement factors and interleukin-6 in paediatric heart surgery. Heparin 0-7 interleukin 6 Homo sapiens 89-102 10840075-10 2000 The profound and rapid 7.5-fold increase in the natural antagonist of human IL-6 cytokine family after RA treatment could abrogate the gp130 signaling required for proliferation and/or expansion of human primitive hemopoietic stem cells and lead to the observed inhibitory effect of RA on CAFC. Tretinoin 103-105 interleukin 6 Homo sapiens 76-80 10840075-10 2000 The profound and rapid 7.5-fold increase in the natural antagonist of human IL-6 cytokine family after RA treatment could abrogate the gp130 signaling required for proliferation and/or expansion of human primitive hemopoietic stem cells and lead to the observed inhibitory effect of RA on CAFC. Tretinoin 283-285 interleukin 6 Homo sapiens 76-80 10619928-8 1999 In contrast, exposure of the leukocytes to Ti3+ ions was associated with a decrease in the release of TNF-alpha and PGE2 and a minimal change in IL-6 noted after 7 days" culture. titanium (III) 43-47 interleukin 6 Homo sapiens 145-149 11155789-7 2000 IL-6 was also able to reverse the inhibitory effect of dexamethasone (1 mumol/l) on GR in both cell lines. Dexamethasone 55-68 interleukin 6 Homo sapiens 0-4 11155807-1 2000 The altered cortisol and adrenal androgen (i.e., dehydroepiandrosterone sulfate = DHEAS) secretion, observed during testing in rheumatoid arthritis (RA) patients not treated with corticosteroids, should be clearly regarded as a "relative adrenal insufficiency" in the setting of a sustained inflammatory process, as shown by high serum IL-6 levels. Dehydroepiandrosterone Sulfate 49-79 interleukin 6 Homo sapiens 336-340 10585421-6 1999 Furthermore, preincubation of the cells with the specific MEK1 inhibitor PD98059 or a dominant negative MEK1 reversed the inhibitory effect of PE, and expression of constitutively activated MEK1 alone abolished IL-6-activated STAT3. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 73-80 interleukin 6 Homo sapiens 211-215 10619980-9 1999 After exercise, the inhibitory effect of Dex on LPS-induced IL-6 production was restored in ET and was no longer significantly different from that obtained in UT. Dexamethasone 41-44 interleukin 6 Homo sapiens 60-64 10600333-4 1999 First, we found that triazolopyrimidine inhibits the production of IL-12, TNF-alpha, and IL-6 by monocytes activated by coculture with fibroblasts transfected with the CD40L gene as well as the induction of procoagulant activity at their membrane. triazolopyrimidine 21-39 interleukin 6 Homo sapiens 89-93 10586114-7 1999 The IL-1-enhanced IL-6 protein secretion was strongly reduced by SB203580 and PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 78-85 interleukin 6 Homo sapiens 18-22 10619980-2 1999 METHODS: For this purpose, in vitro dexamethasone inhibition of lipopolysaccharide (LPS)-induced interleukin-6 (IL-6) secretion in cultures of peripheral monocytes was compared in 6 untrained subjects (UT) and in 6 endurance-trained (ET) men at 0800 h, 24 h after the end of the last session of exercise (ET men). Dexamethasone 36-49 interleukin 6 Homo sapiens 97-110 10619980-2 1999 METHODS: For this purpose, in vitro dexamethasone inhibition of lipopolysaccharide (LPS)-induced interleukin-6 (IL-6) secretion in cultures of peripheral monocytes was compared in 6 untrained subjects (UT) and in 6 endurance-trained (ET) men at 0800 h, 24 h after the end of the last session of exercise (ET men). Dexamethasone 36-49 interleukin 6 Homo sapiens 112-116 10619980-8 1999 Moreover, when sensitivity to dexamethasone (Dex) was studied and expressed as the percent inhibition of stimulated IL-6 production with 0.3 microg/ml LPS, at 0800 h the percent inhibition was lower in ET subjects compared to UT (P < 0.01 ET vs. UT men) for each Dex concentration used [10-11-10-8 M]. Dexamethasone 30-43 interleukin 6 Homo sapiens 116-120 10619980-8 1999 Moreover, when sensitivity to dexamethasone (Dex) was studied and expressed as the percent inhibition of stimulated IL-6 production with 0.3 microg/ml LPS, at 0800 h the percent inhibition was lower in ET subjects compared to UT (P < 0.01 ET vs. UT men) for each Dex concentration used [10-11-10-8 M]. Dexamethasone 45-48 interleukin 6 Homo sapiens 116-120 10701476-10 1999 It is suggested that lower serum Zn in depression may be secondary to sequestration of metallothionein in the liver, which may be related to increased production of interleukin-6. Zinc 33-35 interleukin 6 Homo sapiens 165-178 10613356-1 1999 It has been previously shown that phorbol 12-myristate 13-acetate (PMA), a potent differentiation inducer, induced the expression of both interleukin-6 (IL-6) and IL-6 receptor alpha component (IL-6Ralpha) in K562 leukemia cells. Tetradecanoylphorbol Acetate 67-70 interleukin 6 Homo sapiens 138-151 10658376-8 1999 Lower interleukin-6 and tumor necrosis factor-alpha were found immediately after cardiopulmonary bypass (p < 0.05) and a higher mean postbypass oxygenation index was also seen (p < 0.05) in the heparin-bonded group. Heparin 200-207 interleukin 6 Homo sapiens 6-51 10613356-1 1999 It has been previously shown that phorbol 12-myristate 13-acetate (PMA), a potent differentiation inducer, induced the expression of both interleukin-6 (IL-6) and IL-6 receptor alpha component (IL-6Ralpha) in K562 leukemia cells. Tetradecanoylphorbol Acetate 34-65 interleukin 6 Homo sapiens 138-151 10632522-5 1999 We tested the hypothesis that one of the pathogenetic mechanisms underlying CsA-induced fibrosis is an enhanced IL-6 secretion by gingival fibroblasts (GF) in response to this drug. Cyclosporine 76-79 interleukin 6 Homo sapiens 112-116 10632522-6 1999 METHODS: The ability of CsA to upregulate GF IL-6 secretion alone or in combination with bacterial challenge or other inflammatory cytokines was tested in an in vitro system. Cyclosporine 24-27 interleukin 6 Homo sapiens 45-49 10632522-10 1999 RESULTS: We have shown that GF respond to CsA with an increase in IL-6 secretion. Cyclosporine 42-45 interleukin 6 Homo sapiens 66-70 10632522-12 1999 We have also demonstrated that GF IL-6 responses to bacterial challenge or TNFalpha are downregulated by CsA. Cyclosporine 105-108 interleukin 6 Homo sapiens 34-38 10632522-13 1999 However, CsA synergizes with IL-1beta to further upregulate IL-6 secretion, and this effect is shared by phenytoin and nifedipine. Cyclosporine 9-12 interleukin 6 Homo sapiens 60-64 10613356-1 1999 It has been previously shown that phorbol 12-myristate 13-acetate (PMA), a potent differentiation inducer, induced the expression of both interleukin-6 (IL-6) and IL-6 receptor alpha component (IL-6Ralpha) in K562 leukemia cells. Tetradecanoylphorbol Acetate 67-70 interleukin 6 Homo sapiens 153-157 10613356-1 1999 It has been previously shown that phorbol 12-myristate 13-acetate (PMA), a potent differentiation inducer, induced the expression of both interleukin-6 (IL-6) and IL-6 receptor alpha component (IL-6Ralpha) in K562 leukemia cells. Tetradecanoylphorbol Acetate 34-65 interleukin 6 Homo sapiens 153-157 10613356-1 1999 It has been previously shown that phorbol 12-myristate 13-acetate (PMA), a potent differentiation inducer, induced the expression of both interleukin-6 (IL-6) and IL-6 receptor alpha component (IL-6Ralpha) in K562 leukemia cells. Tetradecanoylphorbol Acetate 34-65 interleukin 6 Homo sapiens 163-167 10613356-1 1999 It has been previously shown that phorbol 12-myristate 13-acetate (PMA), a potent differentiation inducer, induced the expression of both interleukin-6 (IL-6) and IL-6 receptor alpha component (IL-6Ralpha) in K562 leukemia cells. Tetradecanoylphorbol Acetate 67-70 interleukin 6 Homo sapiens 163-167 10718111-1 1999 Increased production of prostaglandins and cytokines by amnion, particularly prostaglandin (PG) E2, interleukin (IL)-6 and IL-8, is thought to be an important event in infection-associated preterm labour. Prostaglandins 24-38 interleukin 6 Homo sapiens 100-118 10574620-9 1999 The three higher IL-6 doses, however, caused significant decreases in testosterone levels by 24 h, which persisted at 48 h and returned to baseline by 7 days. Testosterone 70-82 interleukin 6 Homo sapiens 17-21 10567380-8 1999 Furthermore, enhanced production, mRNA expression, and gene transcription of apo(a) by interleukin-6 were also inhibited by aspirin. Aspirin 124-131 interleukin 6 Homo sapiens 87-100 10585039-8 1999 Plasma levels of cyclic adenosine monophosphate increased significantly (p < 0.05) after the administration of milrinone and the levels correlated inversely (r = -0.55, p < 0.01) with interleukin-6 levels. Cyclic AMP 17-47 interleukin 6 Homo sapiens 190-203 10589757-0 1999 Discovery of differentially expressed genes associated with paclitaxel resistance using cDNA array technology: analysis of interleukin (IL) 6, IL-8, and monocyte chemotactic protein 1 in the paclitaxel-resistant phenotype. Paclitaxel 60-70 interleukin 6 Homo sapiens 123-141 10589757-0 1999 Discovery of differentially expressed genes associated with paclitaxel resistance using cDNA array technology: analysis of interleukin (IL) 6, IL-8, and monocyte chemotactic protein 1 in the paclitaxel-resistant phenotype. Paclitaxel 191-201 interleukin 6 Homo sapiens 123-141 10534331-10 1999 Selective inhibition of either the p44/p42 MAPK pathway, by PD098059, or of the p38 MAPK pathway, by SB203580, blocked proliferation in response to IL-6. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 60-68 interleukin 6 Homo sapiens 148-152 10597281-9 1999 Finally, interleukin-6 (IL-6), a known survival factor for MM cells, inhibits both activation of RAFTK and apoptosis of MM.1S cells triggered by Dex. Dexamethasone 145-148 interleukin 6 Homo sapiens 9-22 10597281-9 1999 Finally, interleukin-6 (IL-6), a known survival factor for MM cells, inhibits both activation of RAFTK and apoptosis of MM.1S cells triggered by Dex. Dexamethasone 145-148 interleukin 6 Homo sapiens 24-28 10602388-9 1999 This indicates that an AlF4-- complex, a known activator of GTP-binding proteins, is involved in fluoride-induced IL-6 and IL-8 responses in A549 cells. Guanosine Triphosphate 60-63 interleukin 6 Homo sapiens 114-118 10574620-11 1999 There also appeared to be small but not significant increases in LH levels after the three higher IL-6 doses, which were not acute and seemed to follow temporally the testosterone decreases. Testosterone 167-179 interleukin 6 Homo sapiens 98-102 10574620-13 1999 In conclusion, subcutaneous IL-6 administration, which caused acute elevations in circulating IL-6 levels of a similar magnitude to those observed in severe inflammatory and noninflammatory stress, induced prolonged suppression in testosterone levels in healthy men without apparent changes in gonadotropin levels. Testosterone 231-243 interleukin 6 Homo sapiens 28-32 10574620-13 1999 In conclusion, subcutaneous IL-6 administration, which caused acute elevations in circulating IL-6 levels of a similar magnitude to those observed in severe inflammatory and noninflammatory stress, induced prolonged suppression in testosterone levels in healthy men without apparent changes in gonadotropin levels. Testosterone 231-243 interleukin 6 Homo sapiens 94-98 10602303-1 1999 This study examined the applicability of luminol-dependent chemiluminescence (CL) response of neutrophils to assess the degree of stress of spinal surgery by measuring the capacity of circulating neutrophils to produce reactive oxygen species and the levels of serum cytokines: interleukin(IL)-1beta, IL-6, IL-8, tumour necrosis factor (TNF)-alpha and granulocyte colony stimulating factor (G-CSF). Luminol 41-48 interleukin 6 Homo sapiens 301-305 10577520-7 1999 Cross-linking of CD163 with monoclonal antibody induced a protein tyrosine kinase-dependent signal that resulted in (1) slow-type calcium mobilization, (2) inositol triphosphate production, and (3) secretion of IL-6 and GM-CSF. Calcium 130-137 interleukin 6 Homo sapiens 211-215 10564544-2 1999 We have shown that the inflammatory cytokines, interleukin-6 (IL-6) and heme-induced HO-1 gene expression, were suppressed by dexamethasone (Dex) in a sustained manner. Dexamethasone 126-139 interleukin 6 Homo sapiens 47-60 10616034-8 1999 Testosterone likewise can inhibit IL-6 induction in androgen-responsive cells, which may include brain glia and astrocytes. Testosterone 0-12 interleukin 6 Homo sapiens 34-38 10564544-2 1999 We have shown that the inflammatory cytokines, interleukin-6 (IL-6) and heme-induced HO-1 gene expression, were suppressed by dexamethasone (Dex) in a sustained manner. Dexamethasone 126-139 interleukin 6 Homo sapiens 62-66 10564544-2 1999 We have shown that the inflammatory cytokines, interleukin-6 (IL-6) and heme-induced HO-1 gene expression, were suppressed by dexamethasone (Dex) in a sustained manner. Dexamethasone 141-144 interleukin 6 Homo sapiens 47-60 10564544-2 1999 We have shown that the inflammatory cytokines, interleukin-6 (IL-6) and heme-induced HO-1 gene expression, were suppressed by dexamethasone (Dex) in a sustained manner. Dexamethasone 141-144 interleukin 6 Homo sapiens 62-66 10564544-6 1999 Although Dex failed to inhibit heme-mediated HO-1 mRNA and HO activity, it was able to reverse IL-6-stimulated HO activity. Dexamethasone 9-12 interleukin 6 Homo sapiens 95-99 10513835-6 1999 However, interleukin-1beta and interleukin-6 concentrations tended to decrease after treatment with Nilvadipine. nilvadipine 100-111 interleukin 6 Homo sapiens 31-44 10599049-0 1999 Etidronate inhibits the production of IL-6 by osteoblast-like cells. Etidronic Acid 0-10 interleukin 6 Homo sapiens 38-42 10614715-8 1999 MTX + EtOH increased the release of IL 6, IL 8 and TNF alpha by 1.0, 1.2, and 1.1 times, respectively. Ethanol 6-10 interleukin 6 Homo sapiens 36-40 10479148-2 1999 IFN-gamma (from the apical pole) and IL-6 (from the basolateral pole) considerably reduced the bacterial intracellular growth, an effect largely abolished by l-monomethyl arginine. omega-N-Methylarginine 158-179 interleukin 6 Homo sapiens 37-41 10504489-11 1999 The role of these activations in IL-6 production was confirmed by the ability of both inhibitors SB203580 (1 to 30 microM) and PD98059 (0.01 to 10 microM) to inhibit basal and TNF-alpha-stimulated IL-6 production in both cell types. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 127-134 interleukin 6 Homo sapiens 33-37 10504489-11 1999 The role of these activations in IL-6 production was confirmed by the ability of both inhibitors SB203580 (1 to 30 microM) and PD98059 (0.01 to 10 microM) to inhibit basal and TNF-alpha-stimulated IL-6 production in both cell types. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 127-134 interleukin 6 Homo sapiens 197-201 10599049-8 1999 However, in osteoblastic-like cells, an inhibition of IL-6 production by etidronate in LPS-stimulated cultures was found. Etidronic Acid 73-83 interleukin 6 Homo sapiens 54-58 10599049-3 1999 Based on these facts, we have studied the effect of etidronate on the production of IL-6 by two tumoral cell lines of human osteoblastic phenotype (MG63 and SaOs cells), and by peripheral blood mononuclear cells (PBMC). Etidronic Acid 52-62 interleukin 6 Homo sapiens 84-88 10467228-7 1999 Dexamethasone markedly suppressed basal production of interleukin (IL)-6 and IL-11 and that stimulated by parathyroid hormone (PTH), IL-1alpha, or tumour necrosis factor-alpha in a dose-dependent manner. Dexamethasone 0-13 interleukin 6 Homo sapiens 54-72 10533294-4 1999 In a previous study, we demonstrated that in vitro interleukin (IL)-1 plus IL-6 stimulated cultured human mesangial cell (HMC) activation to release free oxygen radicals. Reactive Oxygen Species 154-169 interleukin 6 Homo sapiens 75-79 10533294-5 1999 METHODS: In this study, we measured hydrogen peroxide (H2O2) and superoxide anion (O2-) levels after stimulation by IL-1 plus IL-6 in cultured HMCs. Hydrogen Peroxide 36-53 interleukin 6 Homo sapiens 126-130 10533294-5 1999 METHODS: In this study, we measured hydrogen peroxide (H2O2) and superoxide anion (O2-) levels after stimulation by IL-1 plus IL-6 in cultured HMCs. Superoxides 65-81 interleukin 6 Homo sapiens 126-130 10533294-5 1999 METHODS: In this study, we measured hydrogen peroxide (H2O2) and superoxide anion (O2-) levels after stimulation by IL-1 plus IL-6 in cultured HMCs. Superoxides 57-59 interleukin 6 Homo sapiens 126-130 10533294-9 1999 RESULTS: Both 100 microM H2O2 and supernatants of HMCs stimulated by IL-1 10 U/ml plus IL-6 1,000 U/ml caused similar glomerular damage, including blebbing and sloughing of endothelial cells, and denuded basement membrane in glomeruli. Hydrogen Peroxide 25-29 interleukin 6 Homo sapiens 87-91 10456872-7 1999 Interestingly, a 30-base synthetic oligonucleotide containing the palindromic motif GACGTC could stimulate expression of the IL-6 gene and production of its protein in the cells. Oligonucleotides 35-50 interleukin 6 Homo sapiens 125-129 10688417-5 1999 RESULTS: The interleukin-6 values in the steroid group immediately after declamping, as well as at one and three postoperative days were significantly lower than those in the control group. Steroids 41-48 interleukin 6 Homo sapiens 13-26 10467171-0 1999 Interleukin-1beta induces interleukin-6 production through the production of prostaglandin E(2) in human osteoblasts, MG-63 cells. Dinoprostone 77-95 interleukin 6 Homo sapiens 26-39 10467171-7 1999 Anti-PGE(2) antibody markedly reduced the production of IL-6. Dinoprostone 5-11 interleukin 6 Homo sapiens 56-60 10467228-9 1999 As both basal and PTH-stimulated production of IL-6 and IL-11 are decreased by dexamethasone, the increased bone resorption observed in glucocorticoid-induced osteopenia does not appear to be mediated by IL-6 or IL-11. Dexamethasone 79-92 interleukin 6 Homo sapiens 47-51 10471086-0 1999 The non-steroidal anti-inflammatory drug tepoxalin inhibits interleukin-6 and alpha1-anti-chymotrypsin synthesis in astrocytes by preventing degradation of IkappaB-alpha. tepoxalin 41-50 interleukin 6 Homo sapiens 60-73 10469353-1 1999 BACKGROUND: Activation of the cAMP signaling pathway by means of beta2-adrenoceptor agonists has been shown to up-regulate interleukin-6 (IL-6) gene expression and to stimulate IL-6 production in macrophage cells. Cyclic AMP 30-34 interleukin 6 Homo sapiens 123-136 10469353-1 1999 BACKGROUND: Activation of the cAMP signaling pathway by means of beta2-adrenoceptor agonists has been shown to up-regulate interleukin-6 (IL-6) gene expression and to stimulate IL-6 production in macrophage cells. Cyclic AMP 30-34 interleukin 6 Homo sapiens 138-142 10469353-1 1999 BACKGROUND: Activation of the cAMP signaling pathway by means of beta2-adrenoceptor agonists has been shown to up-regulate interleukin-6 (IL-6) gene expression and to stimulate IL-6 production in macrophage cells. Cyclic AMP 30-34 interleukin 6 Homo sapiens 177-181 10469353-8 1999 Following the addition of a cAMP inhibitor, IL-6 promoter activity was correlated with TNF-alpha levels and MAPK activity. Cyclic AMP 28-32 interleukin 6 Homo sapiens 44-48 10469353-10 1999 The terbutaline-induced down-regulation of IL-6 gene production was mediated by an inhibitory effect of terbutaline on TNF-alpha, which was exerted through the MAPK and cAMP pathways, whereas the up-regulation appeared to be due to a direct action of intracellular cAMP. Cyclic AMP 169-173 interleukin 6 Homo sapiens 43-47 10469353-10 1999 The terbutaline-induced down-regulation of IL-6 gene production was mediated by an inhibitory effect of terbutaline on TNF-alpha, which was exerted through the MAPK and cAMP pathways, whereas the up-regulation appeared to be due to a direct action of intracellular cAMP. Cyclic AMP 265-269 interleukin 6 Homo sapiens 43-47 10485589-0 1999 Molecular mechanisms of actions of interleukin-6 on the brain, with special reference to serotonin and the hypothalamo-pituitary-adrenocortical axis. Serotonin 89-98 interleukin 6 Homo sapiens 35-48 10471086-5 1999 Electrophoretic mobility shift and reporter gene assays revealed that tepoxalin exerts its inhibitory effect through the inhibition of nuclear factor kappaB (NF-kappaB), a transcription factor involved in the induction of IL-1, IL-6 and ACT gene expression. tepoxalin 70-79 interleukin 6 Homo sapiens 228-232 10485589-2 1999 IL-6 affects the CNS in that it activates the hypothalamo-pituitary-adrenocortical (HPA) axis and increases brain tryptophan and serotonin metabolism. Serotonin 129-138 interleukin 6 Homo sapiens 0-4 10485589-7 1999 Expression of IL-6 in the brain has been observed in several CNS disorders, some of which have been associated with disorders of serotonin metabolism. Serotonin 129-138 interleukin 6 Homo sapiens 14-18 10446219-3 1999 Serine phosphorylation of Stat3 is also induced by interleukin-6 (IL-6) stimulation, which is shown to be independent of mitogen-activated protein kinase and sensitive to the Ser/Thr kinase inhibitor H7. Serine 0-6 interleukin 6 Homo sapiens 51-64 10485589-8 1999 It is proposed that interactions between IL-6 and brain serotonin is a complex process which involves corticotropin-releasing factor (CRF) and opioid peptides. Serotonin 56-65 interleukin 6 Homo sapiens 41-45 10485589-9 1999 It is likely that the molecular mechanisms underlying the actions of IL-6 on the HPA axis and its other brain functions involve the integrated effects of glutamate, Ca2+, 3",5"-cyclic AMP, protein kinase C, and other metabolic pathways. Glutamic Acid 154-163 interleukin 6 Homo sapiens 69-73 10485589-9 1999 It is likely that the molecular mechanisms underlying the actions of IL-6 on the HPA axis and its other brain functions involve the integrated effects of glutamate, Ca2+, 3",5"-cyclic AMP, protein kinase C, and other metabolic pathways. Cyclic AMP 171-187 interleukin 6 Homo sapiens 69-73 10511209-9 1999 DEX caused dose-dependent inhibition of IL-1-induced IL-6 mRNA expression, while CSA potentiated IL-1-induced OF IL-6 mRNA expression. Dexamethasone 0-3 interleukin 6 Homo sapiens 53-57 10511209-11 1999 DEX is a potent inhibitor of OF IL-6 mRNA while CSA increases IL-1-induced OF IL-6 gene expression. Dexamethasone 0-3 interleukin 6 Homo sapiens 32-36 10515645-2 1999 RESULTS: SIL-2r correlated negatively with 1,25(OH)2D3 (P < 0.01), whereas IL-6 showed a positive correlation with urinary excretion of deoxypyridinoline collagen cross-links (P < 0.01). deoxypyridinoline 139-156 interleukin 6 Homo sapiens 78-82 10458713-9 1999 MCSF, IL-6, and CRP were all reduced after 6 weeks of aspirin treatment (P<0.05). Aspirin 54-61 interleukin 6 Homo sapiens 6-10 10446219-3 1999 Serine phosphorylation of Stat3 is also induced by interleukin-6 (IL-6) stimulation, which is shown to be independent of mitogen-activated protein kinase and sensitive to the Ser/Thr kinase inhibitor H7. Serine 0-6 interleukin 6 Homo sapiens 66-70 10446219-4 1999 In this study, we investigated whether protein kinase C (PKC) is the kinase that is induced and responsible for Stat3 serine phosphorylation by IL-6 stimulation and which isoform of PKCs is likely to be involved. Serine 118-124 interleukin 6 Homo sapiens 144-148 10446065-4 1999 When treated with IL-6, macrophages derived from peripheral monocytes and phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 monocytic cells showed significantly reduced uptake and/or binding of the MSR ligand, acetylated LDL. Tetradecanoylphorbol Acetate 74-105 interleukin 6 Homo sapiens 18-22 10438468-5 1999 IL-6 stimulation of hepatoma cells induced a rapid tyrosine phosphorylation of the p85 subunit of phosphatidylinositol 3-kinase (PI 3-kinase) and its kinase activity followed by the activation of Akt. Tyrosine 51-59 interleukin 6 Homo sapiens 0-4 10445543-8 1999 Longitudinally measured serum IL-6 levels reflected the clinical response during steroid therapy and predicted clinical relapse after steroid-induced remission at week 9 of the treatment protocol. Steroids 81-88 interleukin 6 Homo sapiens 30-34 10445543-8 1999 Longitudinally measured serum IL-6 levels reflected the clinical response during steroid therapy and predicted clinical relapse after steroid-induced remission at week 9 of the treatment protocol. Steroids 134-141 interleukin 6 Homo sapiens 30-34 10444577-5 1999 Reducing cellular ATP below 50% control consistently activated HSF. Adenosine Triphosphate 18-21 interleukin 6 Homo sapiens 63-66 10444577-6 1999 Stepped decrements in cellular ATP below the respective thresholds caused incremental increases in Ca(i), Na(+)-K(+)-ATPase solubility, and HSF activation. Adenosine Triphosphate 31-34 interleukin 6 Homo sapiens 140-143 10445543-9 1999 CONCLUSIONS: Serum IL-6 is a clinically relevant parameter for CD that correlates with inflammatory activity and implies a prognostic value after steroid-induced remission. Steroids 146-153 interleukin 6 Homo sapiens 19-23 10446065-4 1999 When treated with IL-6, macrophages derived from peripheral monocytes and phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 monocytic cells showed significantly reduced uptake and/or binding of the MSR ligand, acetylated LDL. Tetradecanoylphorbol Acetate 107-110 interleukin 6 Homo sapiens 18-22 10431997-13 1999 Increased serum ionized Mg2+ may inhibit arrhythmic recurrence and the production of IL-6 and MMP-1 after reperfusion and prevent the increase of myocardial lesions caused by calcium overload on myocytes. magnesium ion 24-28 interleukin 6 Homo sapiens 85-89 10443688-9 1999 Pretreatment with TNFalpha diminished, and with IL-10 improved, the ability of dexamethasone to suppress IL-6 secretion in whole-blood cell cultures (P < 0.01 for both) and to enhance IL-1 receptor antagonist secretion by U937 cells (P < 0.05 for both). Dexamethasone 79-92 interleukin 6 Homo sapiens 105-109 10405348-9 1999 Both paclitaxel and 2-meOE2 also inhibited stimulation of aromatase activity by IL-6 plus its soluble receptor and PGE(2). Paclitaxel 5-15 interleukin 6 Homo sapiens 80-84 10397717-5 1999 The exposure of cultured mast cells to SCF+IL-6 also caused substantial increases in the cell size, frequency of chymase-positive cells, and intracellular histamine level compared with the values obtained with SCF alone. Histamine 155-164 interleukin 6 Homo sapiens 43-47 10457265-4 1999 Treatment with 5alpha-dihydrotestosterone (DHT) dose-dependently inhibited constitutive and TNF-alpha/IL-1beta-stimulated IL-6 mRNA steady-state levels in hFOB/AR-6 cells by 70-80% at 10-7 M. In addition, testosterone also suppressed TNF-alpha/IL-1beta-stimulated IL-6 mRNA levels by 57%, while the adrenal androgen dehydroepiandrosterone had no effect. Testosterone 29-41 interleukin 6 Homo sapiens 122-126 10457265-4 1999 Treatment with 5alpha-dihydrotestosterone (DHT) dose-dependently inhibited constitutive and TNF-alpha/IL-1beta-stimulated IL-6 mRNA steady-state levels in hFOB/AR-6 cells by 70-80% at 10-7 M. In addition, testosterone also suppressed TNF-alpha/IL-1beta-stimulated IL-6 mRNA levels by 57%, while the adrenal androgen dehydroepiandrosterone had no effect. Testosterone 29-41 interleukin 6 Homo sapiens 264-268 10457265-6 1999 Consistent with the Northern analyses, treatment with 5alpha-DHT, testosterone, and hydroxyflutamide also inhibited IL-6 protein production by 79%, 62%, and 71%, respectively (p < 0.001), while these agents had no effect on IL-6 soluble receptor levels. Testosterone 66-78 interleukin 6 Homo sapiens 116-120 10457265-6 1999 Consistent with the Northern analyses, treatment with 5alpha-DHT, testosterone, and hydroxyflutamide also inhibited IL-6 protein production by 79%, 62%, and 71%, respectively (p < 0.001), while these agents had no effect on IL-6 soluble receptor levels. Testosterone 66-78 interleukin 6 Homo sapiens 227-231 10652584-7 1999 This latter effect seemed to be mediated by PGE2 since SA and INDO reduced PGE2 levels in MDA-MB-231 and Hs578T cells, PGE2 was not detected in MCF-7 and T-47D cells and exogenous PGE2 increased IL-6 and -11 expression by MDA-MB-231 cells. Dinoprostone 44-48 interleukin 6 Homo sapiens 195-207 10391852-6 1999 In addition, proinflammatory cytokine (interleukin 1beta [IL-1beta] and tumor necrosis factor alpha [TNF-alpha]) levels are greater in culture wells containing discs of polyolefin polymer than in those containing discs of polyvinyl chloride polymer with the TEHTM plasticizer, and even more so in storage bags containing polyolefin polymer versus polyvinyl chloride polymer with the TEHTM plasticizer (IL-1beta, TNF-alpha, IL-6, and IL-8). polyolefin polymer 169-187 interleukin 6 Homo sapiens 423-427 10397679-11 1999 Pyrrolidine dithiocarbamate suppressed angiotensin II-induced IL-6 release, a finding compatible with involvement of reactive oxygen species as second messengers in cytokine production mediated by angiotensin. Reactive Oxygen Species 117-140 interleukin 6 Homo sapiens 62-66 10381520-9 1999 Further analysis, comparing the parental OPM-2 cells and a representative transfectant, clone C5, showed that IL-6 caused rapid tyrosine phosphorylation of gp130 in both OPM-2 and C5 clones. Tyrosine 128-136 interleukin 6 Homo sapiens 110-114 10381520-10 1999 Pretreatment with ATRA greatly reduced IL-6-induced gp130 phosphorylation in OPM-2 cells, reflecting a reduction in cellular IL-6Ralpha. Tretinoin 18-22 interleukin 6 Homo sapiens 39-43 10403520-8 1999 The treatment of A2780 cells with N-acetyl-L-cysteine increased the intracellular GSH concentration, and profoundly suppressed hsp72 mRNA induction and HSF activation by CdCl2. Acetylcysteine 34-53 interleukin 6 Homo sapiens 152-155 10403520-10 1999 Our findings suggest that increased GSH biosynthesis in CDDP-resistant cancer cells may be involved in the attenuation of HSF activation by CdCl2. Glutathione 36-39 interleukin 6 Homo sapiens 122-125 10403520-10 1999 Our findings suggest that increased GSH biosynthesis in CDDP-resistant cancer cells may be involved in the attenuation of HSF activation by CdCl2. Cisplatin 56-60 interleukin 6 Homo sapiens 122-125 10489835-6 1999 Addition of GSH and NAC significantly reduced the secretion of TNF-alpha (mean+/-SEM 21.2+/-5 and 44.7+/-4.4% inhibition, respectively) as well as LPS-induced IL-6 and IL-8 (p<0.05). Glutathione 12-15 interleukin 6 Homo sapiens 159-163 10489835-0 1999 Thiol regulation of the production of TNF-alpha, IL-6 and IL-8 by human alveolar macrophages. Sulfhydryl Compounds 0-5 interleukin 6 Homo sapiens 49-53 10489835-6 1999 Addition of GSH and NAC significantly reduced the secretion of TNF-alpha (mean+/-SEM 21.2+/-5 and 44.7+/-4.4% inhibition, respectively) as well as LPS-induced IL-6 and IL-8 (p<0.05). Acetylcysteine 20-23 interleukin 6 Homo sapiens 159-163 10489835-7 1999 Similarly, NAC inhibited the production of TNF-alpha, IL-6 and IL-8 in GSH-depleted AMs obtained by BSO pretreatment. Acetylcysteine 11-14 interleukin 6 Homo sapiens 54-58 10489835-7 1999 Similarly, NAC inhibited the production of TNF-alpha, IL-6 and IL-8 in GSH-depleted AMs obtained by BSO pretreatment. Glutathione 71-74 interleukin 6 Homo sapiens 54-58 10489835-8 1999 In conclusion, N-acetylcysteine and glutathione inhibit the production of tumour necrosis factor-alpha, interleukin-8 and interleukin-6 by alveolar macrophages by a mechanism independent of glutathione metabolism. Acetylcysteine 15-31 interleukin 6 Homo sapiens 122-135 10489835-8 1999 In conclusion, N-acetylcysteine and glutathione inhibit the production of tumour necrosis factor-alpha, interleukin-8 and interleukin-6 by alveolar macrophages by a mechanism independent of glutathione metabolism. Glutathione 36-47 interleukin 6 Homo sapiens 122-135 10405202-3 1999 Stimulation with lipopolysaccharide and IL-1beta resulted in the full induction of IL-6 expression only if the cells were coincubated with cAMP agonists; this effect was attenuated by protein kinase A inhibitors. Cyclic AMP 139-143 interleukin 6 Homo sapiens 83-87 10383937-0 1999 Soluble IL-6 receptor induces calcium flux and selectively modulates chemokine expression in human dermal fibroblasts. Calcium 30-37 interleukin 6 Homo sapiens 8-12 10404009-6 1999 The immunosuppressant cyclosporine A (CsA) inhibited T cell tumor necrosis factor alpha and IL-6 production but did not inhibit the T cell induction of IL-6 from hOB. Cyclosporine 22-36 interleukin 6 Homo sapiens 92-96 10404009-6 1999 The immunosuppressant cyclosporine A (CsA) inhibited T cell tumor necrosis factor alpha and IL-6 production but did not inhibit the T cell induction of IL-6 from hOB. Cyclosporine 38-41 interleukin 6 Homo sapiens 92-96 10404009-8 1999 The induction of IL-6 mRNA by both activated T cell CM and CsA-treated activated T cell CM was confirmed by Northern blot analysis. Cyclosporine 59-62 interleukin 6 Homo sapiens 17-21 10404010-5 1999 The increased cAMP levels caused by the G-protein mutations lead to increased interleukin-6 (IL-6) levels in the affected tissues, resulting in abnormal osteoblast differentiation and increased osteoclastic activity. Cyclic AMP 14-18 interleukin 6 Homo sapiens 78-91 10404010-5 1999 The increased cAMP levels caused by the G-protein mutations lead to increased interleukin-6 (IL-6) levels in the affected tissues, resulting in abnormal osteoblast differentiation and increased osteoclastic activity. Cyclic AMP 14-18 interleukin 6 Homo sapiens 93-97 10366426-5 1999 The results show that cis-diamminedichloroplatinum (CDDP) resistance was overcome by treatment with nontoxic doses of CDDP in combination with anti-IL-6 mAb. Cisplatin 22-50 interleukin 6 Homo sapiens 148-152 10366426-5 1999 The results show that cis-diamminedichloroplatinum (CDDP) resistance was overcome by treatment with nontoxic doses of CDDP in combination with anti-IL-6 mAb. Cisplatin 52-56 interleukin 6 Homo sapiens 148-152 10366426-7 1999 Treatment of cells with anti-IL-6 reduced the levels of glutathione. Glutathione 56-67 interleukin 6 Homo sapiens 29-33 10366426-8 1999 The current studies show that anti-IL-6 mAb sensitized CDDP-resistant K562 cells to CDDP by induction of apoptotic death and the reduction of glutathione levels might be implicated in the enhanced cytotoxicity observed. Cisplatin 55-59 interleukin 6 Homo sapiens 35-39 10366426-8 1999 The current studies show that anti-IL-6 mAb sensitized CDDP-resistant K562 cells to CDDP by induction of apoptotic death and the reduction of glutathione levels might be implicated in the enhanced cytotoxicity observed. Cisplatin 84-88 interleukin 6 Homo sapiens 35-39 10366426-8 1999 The current studies show that anti-IL-6 mAb sensitized CDDP-resistant K562 cells to CDDP by induction of apoptotic death and the reduction of glutathione levels might be implicated in the enhanced cytotoxicity observed. Glutathione 142-153 interleukin 6 Homo sapiens 35-39 10731102-1 1999 Prostaglandin E2 (PGE2) and cytokines, such as interleukin-6 (IL-6) or tumour necrosis factor a (TNFalpha) can regulate aromatase activity. Dinoprostone 0-16 interleukin 6 Homo sapiens 47-60 10389698-7 1999 Crohn"s disease patients had a markedly decreased dexamethasone-mediated inhibition of TNF-alpha (P < 0.01), IL-6 (P < 0.001), and IL-1 beta (P < 0.01) compared to healthy subjects, with a shift of the dexamethasone dose-response curve to the right. Dexamethasone 50-63 interleukin 6 Homo sapiens 112-116 10362698-2 1999 Adenosine inhibits the expression of TNF-alpha and IL-6 in macrophages. Adenosine 0-9 interleukin 6 Homo sapiens 51-55 10362698-4 1999 In myocytes, adenosine suppressed TNF-alpha mRNA by 40% (P < 0.05) and induced a 4.7-fold increase in IL-6 mRNA (P < 0.05) with a twofold increase in IL-6 protein release (P < 0.001). Adenosine 13-22 interleukin 6 Homo sapiens 105-109 10362698-4 1999 In myocytes, adenosine suppressed TNF-alpha mRNA by 40% (P < 0.05) and induced a 4.7-fold increase in IL-6 mRNA (P < 0.05) with a twofold increase in IL-6 protein release (P < 0.001). Adenosine 13-22 interleukin 6 Homo sapiens 156-160 10362713-5 1999 Superoxide anions (O-2), but not hydrogen peroxide (H2O2), increased IL-6 production. Superoxides 0-17 interleukin 6 Homo sapiens 69-73 10362713-5 1999 Superoxide anions (O-2), but not hydrogen peroxide (H2O2), increased IL-6 production. Superoxides 19-22 interleukin 6 Homo sapiens 69-73 10731102-1 1999 Prostaglandin E2 (PGE2) and cytokines, such as interleukin-6 (IL-6) or tumour necrosis factor a (TNFalpha) can regulate aromatase activity. Dinoprostone 0-16 interleukin 6 Homo sapiens 62-66 10731102-6 1999 The ability of PGE2 to stimulate aromatase activity in fibroblasts derived from "normal" breast tissue was potentiated by IL-6sR suggesting that PGE2 may act via induction of IL-6. Dinoprostone 15-19 interleukin 6 Homo sapiens 122-126 10731102-6 1999 The ability of PGE2 to stimulate aromatase activity in fibroblasts derived from "normal" breast tissue was potentiated by IL-6sR suggesting that PGE2 may act via induction of IL-6. Dinoprostone 145-149 interleukin 6 Homo sapiens 122-126 10731102-8 1999 A significant increase in IL-6 concentrations was detected in conditioned medium collected from cells treated with PGE2. Dinoprostone 115-119 interleukin 6 Homo sapiens 26-30 10731102-9 1999 It is concluded that in some fibroblasts PGE2 may exert part of its regulatory effect on breast tissue aromatase activity via induction of IL-6. Dinoprostone 41-45 interleukin 6 Homo sapiens 139-143 10424449-9 1999 Phagocytosis is markedly enhanced and hydrogen peroxide production is slightly enhanced in IL-6 treated M1 cells. Hydrogen Peroxide 38-55 interleukin 6 Homo sapiens 91-95 10424432-4 1999 PD98059, an inhibitor of MAP kinase kinase (MEK), inhibited IL-6, IL-8 and basic FGF production in HS and all cytokines production except basic FGF in SW982. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 interleukin 6 Homo sapiens 60-64 10397515-10 1999 CONCLUSIONS: We concluded that elevated levels of androgens, specifically testosterone and dihydrotestosterone, could affect the stromal cell response to an inflammatory challenge by downregulation of IL-6 production. Testosterone 74-86 interleukin 6 Homo sapiens 201-205 10429944-11 1999 Dexamethasone, over a wide range of concentrations, markedly enhanced proteoglycan synthesis and completely reversed the downregulatory effects of IL-1 and IL-6 + sIL-6Ralpha. Dexamethasone 0-13 interleukin 6 Homo sapiens 156-160 10408981-22 1999 saline infusion on peripheral IL-6 or IL-1ra levels. Sodium Chloride 0-6 interleukin 6 Homo sapiens 30-34 10429944-13 1999 Finally, unlike IL-1, IL-6 + sIL-6Ralpha only weakly stimulated nitric oxide (NO) synthesis. Nitric Oxide 64-76 interleukin 6 Homo sapiens 22-26 10384913-4 1999 In tape stripped skin, levels of prostaglandin E2 and interleukin-1alpha were increased 3.4-fold and 3.3-fold, respectively (p<0.0001; p<0.02), levels of tumour necrosis factor-alpha were decreased 3.0-fold (p<0.01), whereas levels of interleukin-6 and leukotriene B4 in blister fluids remained relatively unchanged. Dinoprostone 33-49 interleukin 6 Homo sapiens 244-257 10513071-7 1999 A positive gradient for interleukin 6 levels was detected throughout the study period with normal intramucosal pH, lactate and oxygen/lactate ratio. Lactic Acid 115-122 interleukin 6 Homo sapiens 24-37 10513071-7 1999 A positive gradient for interleukin 6 levels was detected throughout the study period with normal intramucosal pH, lactate and oxygen/lactate ratio. Oxygen 127-133 interleukin 6 Homo sapiens 24-37 10513071-7 1999 A positive gradient for interleukin 6 levels was detected throughout the study period with normal intramucosal pH, lactate and oxygen/lactate ratio. Lactic Acid 134-141 interleukin 6 Homo sapiens 24-37 10334936-6 1999 We now report that IL-6, a major inducer of acute-phase proteins, stimulates the synthesis and secretion of angiogenin protein in human HepG2 cells within 24 hr following treatment, an effect enhanced by dexamethasone. Dexamethasone 204-217 interleukin 6 Homo sapiens 19-23 10226093-1 1999 BACKGROUND: Calcium channel blockers (CCB) of all subclasses: the dihydropyridines, benzothiazepines, and phenylalkylamines, at nanomolar concentrations, have been shown to up-regulate interleukin-6 (IL-6) mRNA. benzothiazepines 84-100 interleukin 6 Homo sapiens 185-198 10226093-1 1999 BACKGROUND: Calcium channel blockers (CCB) of all subclasses: the dihydropyridines, benzothiazepines, and phenylalkylamines, at nanomolar concentrations, have been shown to up-regulate interleukin-6 (IL-6) mRNA. benzothiazepines 84-100 interleukin 6 Homo sapiens 200-204 10326880-11 1999 CONCLUSION: High levels of IL-6 are suggestive of a genuine intra-amniotic infection with urea-plasmas resulting in adverse pregnancy outcome, while culture-positive amniotic fluids with normal IL-6 levels, may suggest a state of contamination. Urea 90-94 interleukin 6 Homo sapiens 27-31 10360689-0 1999 Signaling pathways for tumor necrosis factor-alpha and interleukin-6 expression in human macrophages exposed to titanium-alloy particulate debris in vitro. Titanium 112-120 interleukin 6 Homo sapiens 55-68 10226072-8 1999 Furthermore, we found significant increases in the release of IL-4, IL-6, IL-8, and TNF-alpha of ozone-exposed (0.1 ppm) samples of atopic versus nonatopic patients and to a lesser extent for histamine following exposure to 0.15 ppm ozone. Ozone 97-102 interleukin 6 Homo sapiens 68-72 10319886-6 1999 Conversely, treatment of PBMCs with the adenosine A1 receptor agonist R-phenylisopropyladenosine (R-PIA) (1 microM) significantly inhibited mitogen-stimulated production of TNF alpha but not IL-6 in control subjects and significantly inhibited production of IL-6 but not TNF alpha in MS patients. r-phenylisopropyladenosine 70-96 interleukin 6 Homo sapiens 191-195 10319886-6 1999 Conversely, treatment of PBMCs with the adenosine A1 receptor agonist R-phenylisopropyladenosine (R-PIA) (1 microM) significantly inhibited mitogen-stimulated production of TNF alpha but not IL-6 in control subjects and significantly inhibited production of IL-6 but not TNF alpha in MS patients. r-phenylisopropyladenosine 70-96 interleukin 6 Homo sapiens 258-262 10408869-7 1999 Among biological parameters analysed, a direct association was found between the percentage of IL-6-positive cells and that of oestrogen (P = 0.00005) and progesterone (P = 0.025) receptor-positive cells. Progesterone 155-167 interleukin 6 Homo sapiens 95-99 10385244-10 1999 MK-571 mediated upregulation of IL-6 in the presence of IL-1 was partially attenuated by SB203580 and PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 102-109 interleukin 6 Homo sapiens 32-36 10319886-9 1999 Taken together, these results suggest that decreased levels of adenosine and its A1 receptor modulate TNF alpha and IL-6 levels and may contribute to the pathogenesis of MS. Adenosine 63-72 interleukin 6 Homo sapiens 116-120 10326962-4 1999 RESULTS: Antazoline hydrochloride, emedastine difumarate, levocabastine hydrochloride, olopatadine hydrochloride, and pheniramine maleate attenuated histamine-stimulated phosphatidylinositol turnover and IL-6 and IL-8 secretion. Histamine 149-158 interleukin 6 Homo sapiens 204-208 10321921-5 1999 Further studies have shown that IL-6, c-fos, and Bcl-2 are all elevated in Paget"s disease--all of these factors can be activated by virally induced ROS. ros 149-152 interleukin 6 Homo sapiens 32-36 10362412-0 1999 Effect of the nitric oxide inhibitor, L-N(G)-monomethylarginine, on accumulation of interleukin-6 and interleukin-8, and nuclear factor-kappaB activity in a human endothelial cell line. Nitric Oxide 14-26 interleukin 6 Homo sapiens 84-97 10360689-9 1999 RESULTS: Exposure of macrophages to titanium-alloy particles in vitro for forty-eight hours resulted in a fortyfold increase in the release of TNF-alpha and a sevenfold increase in the release of IL-6 (p<0.01). Titanium 36-50 interleukin 6 Homo sapiens 196-200 10360689-20 1999 Macrophage release of TNF-alpha and IL-6 in response to particles coincided with increased tyrosine phosphorylation and mitogen-activated protein kinase activation. Tyrosine 91-99 interleukin 6 Homo sapiens 36-40 10360689-25 1999 CONCLUSIONS: These data suggest that particle induced macrophage release of TNF-alpha and IL-6 does not require phagocytosis but is dependent on tyrosine and serine/threonine kinase activity culminating in activation of Tyrosine 145-153 interleukin 6 Homo sapiens 90-94 10231345-12 1999 IL-6 levels in all IBD groups with and without steroids were significantly different from those in control subjects. Steroids 47-55 interleukin 6 Homo sapiens 0-4 10209264-11 1999 It is likely that the higher GSH concentration in A2780CP cells plays an important role in promoting Hsp72 gene expression induced by the mild heat stress probably through processes downstream of activation of HSF-DNA binding. Glutathione 29-32 interleukin 6 Homo sapiens 210-213 10416955-0 1999 Interleukin-6 as a central mediator of cardiovascular risk associated with chronic inflammation, smoking, diabetes, and visceral obesity: down-regulation with essential fatty acids, ethanol and pentoxifylline. Fatty Acids, Essential 159-180 interleukin 6 Homo sapiens 0-13 10416955-0 1999 Interleukin-6 as a central mediator of cardiovascular risk associated with chronic inflammation, smoking, diabetes, and visceral obesity: down-regulation with essential fatty acids, ethanol and pentoxifylline. Ethanol 182-189 interleukin 6 Homo sapiens 0-13 10416955-6 1999 Moderate ethanol consumption, as well as sex-hormone replacement, also appear to inhibit IL-6 production or activity. Ethanol 9-16 interleukin 6 Homo sapiens 89-93 10202034-3 1999 The ERK pathway-specific inhibitor PD98059 inhibited IL-6 secretion from monocytes. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 35-42 interleukin 6 Homo sapiens 53-57 10382942-4 1999 The addition of IL-6 or both IL-6 and MGF to M-CSF containing cultures resulted in significant higher numbers of colony-forming unit-macrophage (CFU-M) as tested in clonogenic and 3H-thymidine assays. Tritium 180-182 interleukin 6 Homo sapiens 16-20 10204831-10 1999 Furthermore, endothelial cell production of IL-6 was increased in zinc-deficient endothelial cells following treatment with fatty acids or TNF. Fatty Acids 124-135 interleukin 6 Homo sapiens 44-48 10094943-11 1999 PD098059 inhibited activation of p44/p42 MAPK in cholangiocytes and completely blocked DNA synthesis in response to IL-6 or LPS. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-8 interleukin 6 Homo sapiens 116-120 10382942-4 1999 The addition of IL-6 or both IL-6 and MGF to M-CSF containing cultures resulted in significant higher numbers of colony-forming unit-macrophage (CFU-M) as tested in clonogenic and 3H-thymidine assays. Tritium 180-182 interleukin 6 Homo sapiens 29-33 10368647-2 1999 Tyrosine phosphorylation of the transcription factor STAT3 plays an important role in IL-6 cytokine family-mediated reactions. Tyrosine 0-8 interleukin 6 Homo sapiens 86-90 10363611-13 1999 Using heparin-coated circuits (group C) also led to a significant (p<0.05) IL-10 upregulation (C: peak at 2 h, 1380 pg/ml) and IL-6 suppression (C: peak at 4 h, 290 pg/ml). Heparin 6-13 interleukin 6 Homo sapiens 130-134 10363611-15 1999 CONCLUSIONS: The results show a similar reduction of the inflammatory cytokine release (IL-6 and IL-8 as markers) using early steroid application and aprotinin in high dosage. Steroids 126-133 interleukin 6 Homo sapiens 88-92 10363611-16 1999 Heparin coating reduces IL-6 and increases IL-10 release, whereas IL-8 is not affected. Heparin 0-7 interleukin 6 Homo sapiens 24-70 10080949-1 1999 Exposure of primary human lung fibroblasts (HLF) to interleukin-6 (IL-6) rapidly induced Stat3 (signal transducers and activators of transcription 3) tyrosine phosphorylation. Tyrosine 150-158 interleukin 6 Homo sapiens 52-65 10080949-1 1999 Exposure of primary human lung fibroblasts (HLF) to interleukin-6 (IL-6) rapidly induced Stat3 (signal transducers and activators of transcription 3) tyrosine phosphorylation. Tyrosine 150-158 interleukin 6 Homo sapiens 67-71 10080949-3 1999 Interestingly, a short pretreatment of cells with alpha-thrombin significantly inhibited IL-6-induced tyrosine phosphorylation of Stat3. Tyrosine 102-110 interleukin 6 Homo sapiens 89-93 10090114-16 1999 Pretreatment erythrocyte sedimentation rate and nonresponsiveness of interleukin 6 to steroid therapy are helpful in dividing patients into subsets with different treatment requirements. Steroids 86-93 interleukin 6 Homo sapiens 69-82 10365139-1 1999 BACKGROUND: Interleukin (IL)-6 can suppress the cisplatin-induced induction of apoptosis in renal cell carcinoma (RCC) in vitro. Cisplatin 48-57 interleukin 6 Homo sapiens 12-30 10382080-0 1999 Interleukin-6 and tumor necrosis factor-alpha concentrations in the intrauterine cavity of postmenopausal women using an intrauterine delivery system releasing progesterone. Progesterone 160-172 interleukin 6 Homo sapiens 0-45 10424406-6 1999 Stepwise multiple linear regression analysis demonstrated that the concentration of IL-6 in breast cyst fluid was predicted statistically by a negative regression coefficient for the concentration of estradiol and DHEA-S, and by a positive regression coefficient for the concentration of TNF-alpha. Estradiol 200-209 interleukin 6 Homo sapiens 84-88 10382080-3 1999 The current study evaluates the concentration of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in the intrauterine fluid of postmenopausal women using an intrauterine delivery system releasing progesterone (IDS-P). Progesterone 212-224 interleukin 6 Homo sapiens 49-62 10086739-4 1999 Moreover, we found IFN-alpha as well as IL-6 can significantly suppress dexamethasone-induced apoptosis. Dexamethasone 72-85 interleukin 6 Homo sapiens 40-44 10225546-4 1999 The aim of this study was to investigate the effects of CsA on the production of 2 cytokines - interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) - by both gingival fibroblasts and peripheral blood mononuclear cells (PBMC). Cyclosporine 56-59 interleukin 6 Homo sapiens 128-141 10225546-4 1999 The aim of this study was to investigate the effects of CsA on the production of 2 cytokines - interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) - by both gingival fibroblasts and peripheral blood mononuclear cells (PBMC). Cyclosporine 56-59 interleukin 6 Homo sapiens 143-147 10225546-7 1999 RESULTS: CsA inhibited IL-6 production by gingival fibroblasts in a dose-dependent manner. Cyclosporine 9-12 interleukin 6 Homo sapiens 23-27 10225546-8 1999 In contrast, at a concentration of 2,000 ng/ml, CsA stimulated IL-6 production by PBMC (P <0.05). Cyclosporine 48-51 interleukin 6 Homo sapiens 63-67 10086739-7 1999 However, IL-6-mediated Bcl-X(L) expression is suppressed in the presence of Dex. Dexamethasone 76-79 interleukin 6 Homo sapiens 9-13 10067009-1 1999 OBJECTIVE: To study whether interleukin-6 (IL-6) changes the expression of the anti-apoptic Bcl-2 protein in the prevention of cis-diaminedichloroplatinum (II) (CDDP)-induced apoptosis of human ovarian cancer cells. Cisplatin 161-165 interleukin 6 Homo sapiens 43-47 10099541-1 1999 Recombinant human interleukin-6 (hIL-6), a pleiotropic cytokine containing two intramolecular disulfide bonds, was expressed in Escherichia coli as an insoluble inclusion body, before being refolded and purified in high yield providing sufficient qualities for clinical use. Disulfides 94-103 interleukin 6 Homo sapiens 33-38 10099541-2 1999 Quantitative reconstitution of the native disulfide bonds of hIL-6 from the fully denatured E. coli extracts could be performed by glutathione-assisted oxidation in a completely denaturating condition (6M guanidinium chloride) at protein concentrations higher than 1 mg/mL, preventing aggregation of reduced hIL-6. Disulfides 42-51 interleukin 6 Homo sapiens 61-66 10099541-2 1999 Quantitative reconstitution of the native disulfide bonds of hIL-6 from the fully denatured E. coli extracts could be performed by glutathione-assisted oxidation in a completely denaturating condition (6M guanidinium chloride) at protein concentrations higher than 1 mg/mL, preventing aggregation of reduced hIL-6. Disulfides 42-51 interleukin 6 Homo sapiens 308-313 10099541-2 1999 Quantitative reconstitution of the native disulfide bonds of hIL-6 from the fully denatured E. coli extracts could be performed by glutathione-assisted oxidation in a completely denaturating condition (6M guanidinium chloride) at protein concentrations higher than 1 mg/mL, preventing aggregation of reduced hIL-6. Glutathione 131-142 interleukin 6 Homo sapiens 61-66 10099541-2 1999 Quantitative reconstitution of the native disulfide bonds of hIL-6 from the fully denatured E. coli extracts could be performed by glutathione-assisted oxidation in a completely denaturating condition (6M guanidinium chloride) at protein concentrations higher than 1 mg/mL, preventing aggregation of reduced hIL-6. Glutathione 131-142 interleukin 6 Homo sapiens 308-313 10067009-7 1999 CONCLUSION: CDDP-induced apoptosis was negatively controlled by IL-6. Cisplatin 12-16 interleukin 6 Homo sapiens 64-68 10023015-8 1999 Especially in kidney cell lines, the levels of granulocyte-macrophage-CSF (GM-CSF), M-CSF and IL-6 were further strongly increased by the TPA and IL-1 pretreatment. Tetradecanoylphorbol Acetate 138-141 interleukin 6 Homo sapiens 94-98 10232875-3 1999 METHODS: Adenosine 5"-triphosphate (ATP) levels in HT29 cells cultured with LPS, IL-1beta, IL-6, or TNF-alpha were measured with high-performance liquid chromatography, using a reversed-phase chromatography column. Adenosine Triphosphate 36-39 interleukin 6 Homo sapiens 91-95 10232875-5 1999 RESULTS: When the cells were cultured with LPS, IL-6, and TNF-alpha but not IL-1beta, ATP levels increased significantly at 6 h, followed by a decrease at 24 h. Enhancement of oxygen consumption, which was completely blocked by antimycin A, was also shown at 3 h by the exposure to these substrates. Oxygen 176-182 interleukin 6 Homo sapiens 48-52 10099541-4 1999 The amount of dimeric hIL-6s, thought to be purification artifacts, was decreased by optimizing the salt concentrations of the loading materials in the ion-exchange chromatography, and gradually removing organic solvents from the collected fractions of the preparative reverse-phase HPLC. Salts 100-104 interleukin 6 Homo sapiens 22-27 10081631-12 1999 A positive linear correlation was observed in the PEGF group between vWF and HA and IL-6. pegf 50-54 interleukin 6 Homo sapiens 84-88 9885283-7 1999 ATP stimulation triggered release of the pro-inflammatory cytokine IL-6 in fibroblasts pre-treated with PMA and bacterial endotoxin. Adenosine Triphosphate 0-3 interleukin 6 Homo sapiens 67-71 9885283-7 1999 ATP stimulation triggered release of the pro-inflammatory cytokine IL-6 in fibroblasts pre-treated with PMA and bacterial endotoxin. Tetradecanoylphorbol Acetate 104-107 interleukin 6 Homo sapiens 67-71 10067009-1 1999 OBJECTIVE: To study whether interleukin-6 (IL-6) changes the expression of the anti-apoptic Bcl-2 protein in the prevention of cis-diaminedichloroplatinum (II) (CDDP)-induced apoptosis of human ovarian cancer cells. Cisplatin 127-159 interleukin 6 Homo sapiens 28-41 10067009-1 1999 OBJECTIVE: To study whether interleukin-6 (IL-6) changes the expression of the anti-apoptic Bcl-2 protein in the prevention of cis-diaminedichloroplatinum (II) (CDDP)-induced apoptosis of human ovarian cancer cells. Cisplatin 127-159 interleukin 6 Homo sapiens 43-47 10067009-1 1999 OBJECTIVE: To study whether interleukin-6 (IL-6) changes the expression of the anti-apoptic Bcl-2 protein in the prevention of cis-diaminedichloroplatinum (II) (CDDP)-induced apoptosis of human ovarian cancer cells. Cisplatin 161-165 interleukin 6 Homo sapiens 28-41 10191628-4 1999 Flow cytometric detection of intracellular cytokines in tonsillar mononuclear cells stimulated with PMA and ionomycin revealed that CD3 cells produced IL-1 alpha, IL-2, IL-4, IL-8, IFN-gamma and TNF-alpha, and CD19 cells produced IL-1 alpha, IL-6, IL-8 and TFN-alpha. Tetradecanoylphorbol Acetate 100-103 interleukin 6 Homo sapiens 242-246 10667331-1 1999 In HepG2 cells phosphorothioate modified antisense oligonucleotides against a sequence in the Ca2+ binding domain (AS-Ca2+) of type II sPLA2 mRNA restrained IL-6-induced synthesis of sPLA2 protein, sPLA2 mRNA (northern blot), and abolished IL-6 stimulated PGE2 release. Oligonucleotides 51-67 interleukin 6 Homo sapiens 157-161 10337430-19 1999 (7) have shown that exposure of human conjunctival epithelial cells to histamine leads to the production of pro-inflammatory cytokines IL-6 and IL-8. Histamine 71-80 interleukin 6 Homo sapiens 135-139 10667331-1 1999 In HepG2 cells phosphorothioate modified antisense oligonucleotides against a sequence in the Ca2+ binding domain (AS-Ca2+) of type II sPLA2 mRNA restrained IL-6-induced synthesis of sPLA2 protein, sPLA2 mRNA (northern blot), and abolished IL-6 stimulated PGE2 release. Oligonucleotides 51-67 interleukin 6 Homo sapiens 240-244 10667331-1 1999 In HepG2 cells phosphorothioate modified antisense oligonucleotides against a sequence in the Ca2+ binding domain (AS-Ca2+) of type II sPLA2 mRNA restrained IL-6-induced synthesis of sPLA2 protein, sPLA2 mRNA (northern blot), and abolished IL-6 stimulated PGE2 release. Dinoprostone 256-260 interleukin 6 Homo sapiens 157-161 10026370-5 1999 Spontaneous secretion of IL-1beta or IL-6 by MC of preterm neonates was less inhibited by dexamethasone as compared with cells from adults. Dexamethasone 90-103 interleukin 6 Homo sapiens 37-41 9934750-12 1999 Only interleukin-6 levels had significant correlations with Child score, plasma renin activity, serum and urinary sodium, and mean arterial pressure (r > or = 0.4, p < 0.005). Sodium 114-120 interleukin 6 Homo sapiens 5-18 9934750-14 1999 Interleukin-6, possibly through nitric oxide-independent mechanisms, also might play a role in the vasodilatation of cirrhosis and the pathogenesis of hepatic encephalopathy. Nitric Oxide 32-44 interleukin 6 Homo sapiens 0-13 10091934-7 1999 There is a statistically significant negative correlation between metal wear and a cytokine (IL-6); cytokines levels do not depend on the implant time to failure and do not correlate with pain score. Metals 66-71 interleukin 6 Homo sapiens 93-97 9892209-4 1999 We show that, in LNCaP prostate cancer cells, elevation of intracellular cAMP can potentiate the ability of epidermal growth factor (EGF), interleukin 6, and serum to activate MAPK and that this potentiation depends on protein kinase A and Rap1. Cyclic AMP 73-77 interleukin 6 Homo sapiens 139-152 9921985-0 1999 Blocking signaling through the Gp130 receptor chain by interleukin-6 and oncostatin M inhibits PC-3 cell growth and sensitizes the tumor cells to etoposide and cisplatin-mediated cytotoxicity. Cisplatin 160-169 interleukin 6 Homo sapiens 55-68 9921985-4 1999 RESULTS: Both endogenous and exogenous IL-6 and exogenous OM up-regulated cell growth and enhanced resistance of PC-3 tumor cells to both etoposide and cisplatin. Cisplatin 152-161 interleukin 6 Homo sapiens 39-43 10385482-5 1999 To solve this problem previously, we established an in vitro model that showed that cultured human mesangial cells (HMC) stimulated with interleukin-1 (IL-1) plus IL-6 can cause mesangial cell proliferation, increasing production of chemical mediators and superoxide anion. Superoxides 256-272 interleukin 6 Homo sapiens 163-167 10579467-3 1999 As enhancement of IL-6 production is related to monocyte activation by melatonin, the hormone acts on human lymphoid cells causing a Th1-type response. Melatonin 71-80 interleukin 6 Homo sapiens 18-22 12938511-2 1999 It was showed that production of IL-8 and mIL-2R was inhibited, but the levels of IL-6 were enhanced by Sinomenine. sinomenine 104-114 interleukin 6 Homo sapiens 82-86 10343934-5 1999 The increase in IL-6 synthesis stimulates prostaglandin and leukotriene production causing dilatation of cervical vessels and further promoting the extravasation of leukocytes. Prostaglandins 42-55 interleukin 6 Homo sapiens 16-20 10343934-5 1999 The increase in IL-6 synthesis stimulates prostaglandin and leukotriene production causing dilatation of cervical vessels and further promoting the extravasation of leukocytes. Leukotrienes 60-71 interleukin 6 Homo sapiens 16-20 10325585-2 1999 Ethanol (EtOH) may play a role in the pathogenesis of psoriasis by upregulating the expression and inducing the local secretion of proinflammatory cytokines, e.g. interleukins IL-1alpha, IL-6, chemokine IL-8 and tumor necrosis factor alpha (TNF-alpha). Ethanol 0-7 interleukin 6 Homo sapiens 187-191 10704080-3 1999 We measured the effect of CsA on basal and phorbol-myristate-acetate (PMA)-stimulated production of interleukin-6 using the human monocyte cell line U937 differentiated with dimethylsulfoxide (DMSO). Cyclosporine 26-29 interleukin 6 Homo sapiens 100-113 10704080-3 1999 We measured the effect of CsA on basal and phorbol-myristate-acetate (PMA)-stimulated production of interleukin-6 using the human monocyte cell line U937 differentiated with dimethylsulfoxide (DMSO). Tetradecanoylphorbol Acetate 43-68 interleukin 6 Homo sapiens 100-113 10704080-3 1999 We measured the effect of CsA on basal and phorbol-myristate-acetate (PMA)-stimulated production of interleukin-6 using the human monocyte cell line U937 differentiated with dimethylsulfoxide (DMSO). Tetradecanoylphorbol Acetate 70-73 interleukin 6 Homo sapiens 100-113 10704080-5 1999 We found that CsA decreases not only IL-6 release but also cytokine synthesis. Cyclosporine 14-17 interleukin 6 Homo sapiens 37-41 10704080-7 1999 Three possibilities may be advanced to explain the CsA-due decrease in IL-6 production by macrophages: (a) inhibition of the synthesis of an early common regulatory protein, (b) inhibition of cytokine gene transcription, or (c) modulation of post-transcriptional events. Cyclosporine 51-54 interleukin 6 Homo sapiens 71-75 10704080-13 1999 We conclude that in human macrophages CsA diminishes IL-6 production at post-transcriptional level. Cyclosporine 38-41 interleukin 6 Homo sapiens 53-57 9882597-1 1999 Recent experiments have shown that human bronchial epithelial cells (i.e., BEAS-2B) release pro-inflammatory cytokines (i.e., IL-6 and TNFalpha) in a receptor-mediated fashion in response to the neuropeptides, substance P (SP), calcitonin gene-related protein (CGRP), and the prototype botanical irritant capsaicin. Capsaicin 305-314 interleukin 6 Homo sapiens 126-143 10609609-1 1999 The active entity responsible for inducing interleukin-6 production by human gingival fibroblasts was partially purified by ion-exchange chromatography from the water-soluble fraction of Mycoplasma salivarium cells. Water 161-166 interleukin 6 Homo sapiens 43-56 9884428-6 1999 Among the patients positive for interleukin-6, 24-hour urinary protein excretion and serum creatinine levels were significantly higher at the time of biopsy than in the patients without interleukin-6 positivity, while creatinine clearance was significantly lower. Creatinine 91-101 interleukin 6 Homo sapiens 32-45 9884428-6 1999 Among the patients positive for interleukin-6, 24-hour urinary protein excretion and serum creatinine levels were significantly higher at the time of biopsy than in the patients without interleukin-6 positivity, while creatinine clearance was significantly lower. Creatinine 218-228 interleukin 6 Homo sapiens 32-45 9884428-7 1999 In the interleukin-6-positive patients without steroid therapy, serum creatinine increased significantly after 1 year (Deltas-Cr; 1.04 +/- 0.45 mg/dl) and creatinine clearance decreased significantly (DeltaCcr; -11.7 +/- 3.2 ml/min) compared to the interleukin-6-negative patients without steroid therapy. Creatinine 70-80 interleukin 6 Homo sapiens 7-20 9884428-7 1999 In the interleukin-6-positive patients without steroid therapy, serum creatinine increased significantly after 1 year (Deltas-Cr; 1.04 +/- 0.45 mg/dl) and creatinine clearance decreased significantly (DeltaCcr; -11.7 +/- 3.2 ml/min) compared to the interleukin-6-negative patients without steroid therapy. Creatinine 155-165 interleukin 6 Homo sapiens 7-20 9884428-7 1999 In the interleukin-6-positive patients without steroid therapy, serum creatinine increased significantly after 1 year (Deltas-Cr; 1.04 +/- 0.45 mg/dl) and creatinine clearance decreased significantly (DeltaCcr; -11.7 +/- 3.2 ml/min) compared to the interleukin-6-negative patients without steroid therapy. Steroids 289-296 interleukin 6 Homo sapiens 7-20 9884428-8 1999 Steroid therapy improved 24-hour urinary protein excretion, serum creatinine, and creatinine clearance in the interleukin-6-positive patients, while these parameters worsened without steroid therapy. Steroids 0-7 interleukin 6 Homo sapiens 110-123 9884428-8 1999 Steroid therapy improved 24-hour urinary protein excretion, serum creatinine, and creatinine clearance in the interleukin-6-positive patients, while these parameters worsened without steroid therapy. Creatinine 82-92 interleukin 6 Homo sapiens 110-123 9884428-10 1999 In conclusion, glomerular interleukin-6 positivity may be a prognostic factor and an indicator of the need for steroid therapy in IgA nephropathy. Steroids 111-118 interleukin 6 Homo sapiens 26-39 10325585-2 1999 Ethanol (EtOH) may play a role in the pathogenesis of psoriasis by upregulating the expression and inducing the local secretion of proinflammatory cytokines, e.g. interleukins IL-1alpha, IL-6, chemokine IL-8 and tumor necrosis factor alpha (TNF-alpha). Ethanol 9-13 interleukin 6 Homo sapiens 187-191 9852582-4 1998 Here, we show, using current- and voltage-clamp recordings, that chronic IL-6 treatment of developing cerebellar granule neurons increases the membrane and current response to NMDA and that these effects are the primary mechanism through which IL-6 produces an enhanced calcium signal to NMDA. Calcium 270-277 interleukin 6 Homo sapiens 73-77 9852582-4 1998 Here, we show, using current- and voltage-clamp recordings, that chronic IL-6 treatment of developing cerebellar granule neurons increases the membrane and current response to NMDA and that these effects are the primary mechanism through which IL-6 produces an enhanced calcium signal to NMDA. Calcium 270-277 interleukin 6 Homo sapiens 244-248 9852582-5 1998 We also show that calcium influx through voltage-sensitive calcium channels contributes to the enhanced calcium signal to NMDA in the IL-6-treated neurons in a developmentally regulated manner and that the membrane depolarization to NMDA is more sensitive to the NMDA receptor antagonist ifenprodil in the IL-6-treated neurons compared with control neurons at a late developmental stage, consistent with a larger proportion of NMDA receptors containing the NMDAR2B subunit in the IL-6-treated neurons. Calcium 18-25 interleukin 6 Homo sapiens 134-138 9856766-8 1998 Histamine (100 microM) and interleukin-1alpha (IL-1alpha, 10 ng/ml) significantly stimulated IL-6 and granulocyte macrophage colony-stimulating factor release, and histamine, BK, and PAF stimulated the mRNA for MMP-1 in these cells. Histamine 0-9 interleukin 6 Homo sapiens 93-97 9852582-5 1998 We also show that calcium influx through voltage-sensitive calcium channels contributes to the enhanced calcium signal to NMDA in the IL-6-treated neurons in a developmentally regulated manner and that the membrane depolarization to NMDA is more sensitive to the NMDA receptor antagonist ifenprodil in the IL-6-treated neurons compared with control neurons at a late developmental stage, consistent with a larger proportion of NMDA receptors containing the NMDAR2B subunit in the IL-6-treated neurons. Calcium 18-25 interleukin 6 Homo sapiens 306-310 9852582-5 1998 We also show that calcium influx through voltage-sensitive calcium channels contributes to the enhanced calcium signal to NMDA in the IL-6-treated neurons in a developmentally regulated manner and that the membrane depolarization to NMDA is more sensitive to the NMDA receptor antagonist ifenprodil in the IL-6-treated neurons compared with control neurons at a late developmental stage, consistent with a larger proportion of NMDA receptors containing the NMDAR2B subunit in the IL-6-treated neurons. Calcium 18-25 interleukin 6 Homo sapiens 306-310 9852582-5 1998 We also show that calcium influx through voltage-sensitive calcium channels contributes to the enhanced calcium signal to NMDA in the IL-6-treated neurons in a developmentally regulated manner and that the membrane depolarization to NMDA is more sensitive to the NMDA receptor antagonist ifenprodil in the IL-6-treated neurons compared with control neurons at a late developmental stage, consistent with a larger proportion of NMDA receptors containing the NMDAR2B subunit in the IL-6-treated neurons. Calcium 59-66 interleukin 6 Homo sapiens 134-138 9852582-5 1998 We also show that calcium influx through voltage-sensitive calcium channels contributes to the enhanced calcium signal to NMDA in the IL-6-treated neurons in a developmentally regulated manner and that the membrane depolarization to NMDA is more sensitive to the NMDA receptor antagonist ifenprodil in the IL-6-treated neurons compared with control neurons at a late developmental stage, consistent with a larger proportion of NMDA receptors containing the NMDAR2B subunit in the IL-6-treated neurons. Calcium 59-66 interleukin 6 Homo sapiens 306-310 9852582-5 1998 We also show that calcium influx through voltage-sensitive calcium channels contributes to the enhanced calcium signal to NMDA in the IL-6-treated neurons in a developmentally regulated manner and that the membrane depolarization to NMDA is more sensitive to the NMDA receptor antagonist ifenprodil in the IL-6-treated neurons compared with control neurons at a late developmental stage, consistent with a larger proportion of NMDA receptors containing the NMDAR2B subunit in the IL-6-treated neurons. Calcium 59-66 interleukin 6 Homo sapiens 306-310 9852582-5 1998 We also show that calcium influx through voltage-sensitive calcium channels contributes to the enhanced calcium signal to NMDA in the IL-6-treated neurons in a developmentally regulated manner and that the membrane depolarization to NMDA is more sensitive to the NMDA receptor antagonist ifenprodil in the IL-6-treated neurons compared with control neurons at a late developmental stage, consistent with a larger proportion of NMDA receptors containing the NMDAR2B subunit in the IL-6-treated neurons. ifenprodil 288-298 interleukin 6 Homo sapiens 134-138 9852582-5 1998 We also show that calcium influx through voltage-sensitive calcium channels contributes to the enhanced calcium signal to NMDA in the IL-6-treated neurons in a developmentally regulated manner and that the membrane depolarization to NMDA is more sensitive to the NMDA receptor antagonist ifenprodil in the IL-6-treated neurons compared with control neurons at a late developmental stage, consistent with a larger proportion of NMDA receptors containing the NMDAR2B subunit in the IL-6-treated neurons. ifenprodil 288-298 interleukin 6 Homo sapiens 306-310 9852582-5 1998 We also show that calcium influx through voltage-sensitive calcium channels contributes to the enhanced calcium signal to NMDA in the IL-6-treated neurons in a developmentally regulated manner and that the membrane depolarization to NMDA is more sensitive to the NMDA receptor antagonist ifenprodil in the IL-6-treated neurons compared with control neurons at a late developmental stage, consistent with a larger proportion of NMDA receptors containing the NMDAR2B subunit in the IL-6-treated neurons. ifenprodil 288-298 interleukin 6 Homo sapiens 306-310 9886334-6 1998 We demonstrated that IL-1 was mainly responsible for IL-6 production in the tumoural environment through a PGE2 loop. Dinoprostone 107-111 interleukin 6 Homo sapiens 53-57 9886334-7 1998 In fact, an IL-1 receptor antagonist (IL-1RA) blocked PGE2 synthesis and IL-6 production by 80%; this blockage could be reversed by adding synthetic PGE2. Dinoprostone 149-153 interleukin 6 Homo sapiens 73-77 9988429-4 1998 Histamine has been shown to increase the adhesion of leucocytes to the endothelium and to stimulate production of IL-6 and IL-8 by endothelial cells. Histamine 0-9 interleukin 6 Homo sapiens 114-118 9874511-8 1998 IL-6 completely abolished detectable expression of BMP-2 mRNA, which was also greatly reduced by IL-1beta, retinoic acid and 1,25(OH)2 vitamin D3. Tretinoin 107-120 interleukin 6 Homo sapiens 0-4 9875677-3 1998 The cultivation of human peripheral blood mononuclear cells (PBMC) in the presence of cisplatin (0-1.0 microg/ml) or 5-FU (0-5.0 microg/ml) resulted in the significant augmentation of natural killer (NK) and lymphokine-activated killer (LAK) cell activities as well as generation of interferon (IFN) gamma, tumor necrosis factor (TNF) alpha, beta interleukin(IL)-1beta, IL-6 and IL-12 in vitro. Cisplatin 86-95 interleukin 6 Homo sapiens 370-374 9875677-3 1998 The cultivation of human peripheral blood mononuclear cells (PBMC) in the presence of cisplatin (0-1.0 microg/ml) or 5-FU (0-5.0 microg/ml) resulted in the significant augmentation of natural killer (NK) and lymphokine-activated killer (LAK) cell activities as well as generation of interferon (IFN) gamma, tumor necrosis factor (TNF) alpha, beta interleukin(IL)-1beta, IL-6 and IL-12 in vitro. Fluorouracil 117-121 interleukin 6 Homo sapiens 370-374 10049521-2 1998 IL-6 increases the activity of the 17beta-oxidoreductase, which converts oestrone to oestradiol, a process that may contribute to the increased concentration of oestrogen around breast tumours. Estradiol 85-95 interleukin 6 Homo sapiens 0-4 18505519-4 1998 The extent of variations obtained on MMP-1 and TIMP-1 levels, when HSF culture medium was supplemented with 10-5 m RA, could be obtained using a 100-fold lower concentration of RA encapsulated into CER vesicles. Tretinoin 177-179 interleukin 6 Homo sapiens 67-70 18505519-6 1998 The rate of internalization of RA into HSF was increased when used in its CER encapsulated form. Tretinoin 31-33 interleukin 6 Homo sapiens 39-42 18505519-3 1998 All-trans retinoic acid significantly decreased and increased the secretions of MMP-1 and TIMP-1 respectively, in a dose-dependent manner, from 10-7 m to 10-5 m. Entrapment of RA into CER vesicles potentiated its effect on MMP-1 and TIMP-1 secretions by HSF, independently of cell passages. Tretinoin 10-23 interleukin 6 Homo sapiens 254-257 18505519-3 1998 All-trans retinoic acid significantly decreased and increased the secretions of MMP-1 and TIMP-1 respectively, in a dose-dependent manner, from 10-7 m to 10-5 m. Entrapment of RA into CER vesicles potentiated its effect on MMP-1 and TIMP-1 secretions by HSF, independently of cell passages. Tretinoin 176-178 interleukin 6 Homo sapiens 254-257 9853559-0 1998 Suppressive effect of ethanol on the expression of hepatic asialoglycoprotein receptors augmented by interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha. Ethanol 22-29 interleukin 6 Homo sapiens 120-133 9832618-3 1998 Both synthetic and natural glucocorticoids, i.e., dexamethasone (DEX) and hydrocortisone (HC), respectively, concentration-dependently inhibited protein production and gene expression of IL-6 by human FLSs. Dexamethasone 50-63 interleukin 6 Homo sapiens 187-191 9832618-3 1998 Both synthetic and natural glucocorticoids, i.e., dexamethasone (DEX) and hydrocortisone (HC), respectively, concentration-dependently inhibited protein production and gene expression of IL-6 by human FLSs. Dexamethasone 65-68 interleukin 6 Homo sapiens 187-191 9832618-3 1998 Both synthetic and natural glucocorticoids, i.e., dexamethasone (DEX) and hydrocortisone (HC), respectively, concentration-dependently inhibited protein production and gene expression of IL-6 by human FLSs. Hydrocortisone 74-88 interleukin 6 Homo sapiens 187-191 9832618-5 1998 DEX significantly reduced the rate of IL-6 gene transcription without affecting the stability of IL-6 mRNA. Dexamethasone 0-3 interleukin 6 Homo sapiens 38-42 9990216-5 1998 The increased production of prostaglandin E2 by upregulation of COX-2 increases IL-6 production. Dinoprostone 28-44 interleukin 6 Homo sapiens 80-84 9916882-0 1998 Involvement of nuclear binding sites for melatonin in the regulation of IL-2 and IL-6 production by human blood mononuclear cells. Melatonin 41-50 interleukin 6 Homo sapiens 81-85 9916882-2 1998 In this paper, we have extended our studies on the influence of melatonin on IL-2 and IL-6 production by human peripheral blood mononuclear cells (PBMCs) by comparing the effects of the specific membrane receptor agonist S 20098, the RZR/ROR(alpha) receptor agonist CGP 52608, and structurally related thiazolidinediones. Melatonin 64-73 interleukin 6 Homo sapiens 86-90 9853285-7 1998 RESULTS: While short (30 min) pre-exposure to lactate buffered PDF significantly reduced the IL-1 beta-stimulated IL-6 release from HPMC during a subsequent recovery period (24 hr), a significant decrease in HPMC IL-6 secretion with bicarbonate buffered PDF was only observed after prolonged (> or = 60 min) exposure. Lactic Acid 46-53 interleukin 6 Homo sapiens 114-118 9853285-7 1998 RESULTS: While short (30 min) pre-exposure to lactate buffered PDF significantly reduced the IL-1 beta-stimulated IL-6 release from HPMC during a subsequent recovery period (24 hr), a significant decrease in HPMC IL-6 secretion with bicarbonate buffered PDF was only observed after prolonged (> or = 60 min) exposure. Lactic Acid 46-53 interleukin 6 Homo sapiens 213-217 9990216-6 1998 By utilizing a COX-2 blocker, it is possible to decrease IL-6 production via reduction of prostanoid production, thereby attenuating the systemic inflammatory response. Prostaglandins 90-100 interleukin 6 Homo sapiens 57-61 9794795-3 1998 The tyrosine phosphorylated STAT factors dissociate from the receptor, dimerize and translocate to the nucleus where they bind to enhancer sequences of IL-6 target genes. Tyrosine 4-12 interleukin 6 Homo sapiens 152-156 9808569-9 1998 Thymocyte adhesion or cross-linking of MoAbs bound to integrins clustered at the TEC/thymocyte contact sites led to activation of interleukin-6 (IL-6) gene transcription factors, namely NF-IL6 serine phosphorylation and NF-kappaB nuclear targeting, as well as to increased IL-6 secretion. Serine 193-199 interleukin 6 Homo sapiens 130-143 9808569-9 1998 Thymocyte adhesion or cross-linking of MoAbs bound to integrins clustered at the TEC/thymocyte contact sites led to activation of interleukin-6 (IL-6) gene transcription factors, namely NF-IL6 serine phosphorylation and NF-kappaB nuclear targeting, as well as to increased IL-6 secretion. Serine 193-199 interleukin 6 Homo sapiens 145-149 9822513-9 1998 0-12148, P =.01; interleukin 6 median 2005 ng/mg creatinine, range 27-4071, vs 990 ng/mg creatinine, range 7.5-3409, P =.005; interleukin 8: median 4933 ng/mg creatinine, range 0.0-55058, vs 61 ng/mg creatinine, range 0.0-2399, P =.005). Creatinine 49-59 interleukin 6 Homo sapiens 17-30 9891500-0 1998 Dexamethasone enhances expression of membrane and soluble interleukin-6 receptors by prostate carcinoma cell lines. Dexamethasone 0-13 interleukin 6 Homo sapiens 58-71 9891500-8 1998 RESULTS: IL-6 induced tyrosine-phosphorylated proteins in LNCaP but not in PC-3 or DU 145, indicating that LNCaP cells express the functional IL-6 receptor. Tyrosine 22-30 interleukin 6 Homo sapiens 9-13 9891500-8 1998 RESULTS: IL-6 induced tyrosine-phosphorylated proteins in LNCaP but not in PC-3 or DU 145, indicating that LNCaP cells express the functional IL-6 receptor. Tyrosine 22-30 interleukin 6 Homo sapiens 142-146 9891500-9 1998 Dexamethasone (Dex)-treatment induced functional IL-6 receptors on DU 145 and PC-3 through upregulation of IL-6R alpha and gpl30. Dexamethasone 0-13 interleukin 6 Homo sapiens 49-53 9835360-11 1998 IL-6 significantly inhibited human chorionic gonadotrophin (HCG)-induced progesterone secretion of GC. Progesterone 73-85 interleukin 6 Homo sapiens 0-4 9891500-9 1998 Dexamethasone (Dex)-treatment induced functional IL-6 receptors on DU 145 and PC-3 through upregulation of IL-6R alpha and gpl30. Dexamethasone 0-3 interleukin 6 Homo sapiens 49-53 9877394-4 1998 When unstimulated lymphocytes and monocytes were co-cultured with titanium-stimulated monocytes, they significantly suppressed the secretion of both interleukin-6 and tumor necrosis factor-alpha. Titanium 66-74 interleukin 6 Homo sapiens 149-194 9845273-3 1998 Furthermore, prostaglandins can stimulate T98G to secrete interleukin-6, which in turn triggers the formation of additional prostaglandins. Prostaglandins 13-27 interleukin 6 Homo sapiens 58-71 9845273-3 1998 Furthermore, prostaglandins can stimulate T98G to secrete interleukin-6, which in turn triggers the formation of additional prostaglandins. Prostaglandins 124-138 interleukin 6 Homo sapiens 58-71 10374580-8 1998 Release of TNF and IL-6 could be stimulated by mineral dust, such as quartz, asbestos and uranium mineral dust, and their activities were significantly higher than those in the control group, with those of 1,396, 1,198 and 852 U/ml in TNF group and 1,336, 1511 and 1,335 U/ml in IL-6 group, respectively. Uranium 90-97 interleukin 6 Homo sapiens 19-23 9765276-6 1998 IL-17 effects on NO release, as well as iNOS, COX-2, and IL-6 protein expression, were inhibited by the anti-inflammatory drug dexamethasone. Dexamethasone 127-140 interleukin 6 Homo sapiens 57-61 9763575-8 1998 Although the exact mode of action for this agent is currently unknown, its ability to kill steroid sensitive and insensitive multiple myeloma cells in an IL-6 independent fashion may offer exciting new therapeutic options. Steroids 91-98 interleukin 6 Homo sapiens 154-158 9761757-6 1998 In the presence of IL-6 antisense oligonucleotides, both proliferation and IL-6 synthesis were downregulated. Oligonucleotides 34-50 interleukin 6 Homo sapiens 19-23 9794205-13 1998 Expression of several proinflammatory cytokines including TNF-alpha, IL-6, IL-1beta, and IFN-gamma were also elevated in Av-exposed animals and modulated by dexamethasone. Dexamethasone 157-170 interleukin 6 Homo sapiens 69-73 9761757-6 1998 In the presence of IL-6 antisense oligonucleotides, both proliferation and IL-6 synthesis were downregulated. Oligonucleotides 34-50 interleukin 6 Homo sapiens 75-79 9761757-8 1998 In these NSCLC cell lines, FCS only marginally increased cell proliferation and IL-6 antisense oligonucleotides did not affect cell proliferation. Oligonucleotides 95-111 interleukin 6 Homo sapiens 80-84 9778268-0 1998 Amelioration of flulike symptoms at the onset of interferon beta-1b therapy in multiple sclerosis by low-dose oral steroids is related to a decrease in interleukin-6 induction. Steroids 115-123 interleukin 6 Homo sapiens 152-165 9761763-5 1998 Using cultures of primary human pulmonary fibroblasts and pulmonary vascular smooth muscle cells (VSMC) we show that hypoxia (3% O2) induced transcription and translation of IL-6 (4- to 5-fold) and IL-8 (5- to 6-fold) in both cell types. Oxygen 129-131 interleukin 6 Homo sapiens 174-178 9829848-3 1998 Following steroid treatment, all values approached normal, i.e., TPO (20 [18.75] pg/ml) was increased and IL-6 (19.5 [13] pg/ml) and P-selectin (248 [172.5] ng/ml) were decreased, significantly. Steroids 10-17 interleukin 6 Homo sapiens 106-110 9853701-10 1998 A significant correlation was found between IL-6 values and CRP, ALT, total bilirubin, GGT and creatinine, but not amylase. Creatinine 95-105 interleukin 6 Homo sapiens 44-48 9853701-9 1998 Portal IL-6 levels were correlated with the corresponding fasting serum glucose values. Glucose 72-79 interleukin 6 Homo sapiens 7-11 9811531-7 1998 In contrast PGE2 significantly stimulates serum-induced IL-6 synthesis. Dinoprostone 12-16 interleukin 6 Homo sapiens 56-60 9736697-1 1998 Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced Stat3 activation. Ionomycin 153-162 interleukin 6 Homo sapiens 268-272 9788898-5 1998 ROS/RNS appear to play a variety of roles that lead to changes in expression of genes such as interleukin-6 and intercellular adhesion molecule 1. ros 0-3 interleukin 6 Homo sapiens 94-107 9917867-6 1998 In addition, we show that IL-6 differs from other pyrogens in being able to stimulate specifically PGE2 synthesis. Dinoprostone 99-103 interleukin 6 Homo sapiens 26-30 9768679-8 1998 DEX treatment also significantly reduced levels of IL-6 and tumor necrosis factor-alpha in culture medium, suggesting that glucocorticoids coordinately reduce cytokine levels in cytotrophoblasts. Dexamethasone 0-3 interleukin 6 Homo sapiens 51-87 9826123-7 1998 In hematopoiesis-depressed mice induced by preinjection with 5-fluorouracil at the dose of 150 mg/kg before cell implantation, the platelets, neutrophils, and white blood cells showed accelerated recovery, and the numbers of CFU-GM and CFU-MK formed by bone marrow cells were also markedly higher after the combined implantation of NIH3T3-IL-3 and NIH3T3-IL-6 cells than in control groups. Fluorouracil 61-75 interleukin 6 Homo sapiens 355-359 9736697-1 1998 Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced Stat3 activation. Ionomycin 153-162 interleukin 6 Homo sapiens 56-69 9736697-1 1998 Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced Stat3 activation. Ionomycin 153-162 interleukin 6 Homo sapiens 71-75 9736697-1 1998 Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced Stat3 activation. Tetradecanoylphorbol Acetate 218-249 interleukin 6 Homo sapiens 56-69 9736697-1 1998 Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced Stat3 activation. Tetradecanoylphorbol Acetate 218-249 interleukin 6 Homo sapiens 71-75 9736697-1 1998 Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced Stat3 activation. Tetradecanoylphorbol Acetate 218-249 interleukin 6 Homo sapiens 268-272 9736697-1 1998 Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced Stat3 activation. Tetradecanoylphorbol Acetate 251-254 interleukin 6 Homo sapiens 56-69 9743379-5 1998 Cross-linking CD40 on ASM resulted in enhanced IL-6 secretion and an increase in intracellular calcium concentrations, which were dependent on calcium influx. Calcium 143-150 interleukin 6 Homo sapiens 47-51 9736697-1 1998 Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced Stat3 activation. Tetradecanoylphorbol Acetate 251-254 interleukin 6 Homo sapiens 71-75 9743379-8 1998 In addition, inhibition of calcium influx inhibited both CD40-mediated NF-kappaB activation and enhancement of IL-6 secretion. Calcium 27-34 interleukin 6 Homo sapiens 111-115 9736697-1 1998 Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced Stat3 activation. Tetradecanoylphorbol Acetate 251-254 interleukin 6 Homo sapiens 268-272 9736697-3 1998 Inhibition of IL-6-induced Stat3 activation by PMA and ionomycin was rapid (within 5 min) and did not require new RNA or protein synthesis. Ionomycin 55-64 interleukin 6 Homo sapiens 14-18 9736697-8 1998 MEKs and ERKs inhibited IL-6 activation of Stat3 harboring a mutation at serine-727, the major site for serine phosphorylation, similar to inhibition of wild-type Stat3, and inhibited Janus kinases Jak1 and Jak2 upstream of Stat3 in the Jak-STAT-signaling pathway. Serine 73-79 interleukin 6 Homo sapiens 24-28 9736697-8 1998 MEKs and ERKs inhibited IL-6 activation of Stat3 harboring a mutation at serine-727, the major site for serine phosphorylation, similar to inhibition of wild-type Stat3, and inhibited Janus kinases Jak1 and Jak2 upstream of Stat3 in the Jak-STAT-signaling pathway. Serine 104-110 interleukin 6 Homo sapiens 24-28 9823419-3 1998 On a population of patients having presented an increase of plasma histamine and/or tryptase (n = 14), we have shown that the concentrations of tryptase, histamine and IL6 respectively plateaued (63.9 +/- 70 micrograms/l et 74 +/- 102 micrograms/l), decreased (82.5 +/- 102 mmole/l et 20.5 +/- 27 mmole/l), or greatly increased (19.5 +/- 25.3 ng/l et 320 +/- 745 ng/l) at 30 and 90 min. Histamine 67-76 interleukin 6 Homo sapiens 168-171 9732294-7 1998 Additionally, IL-6 (5 pg/l to 10 microg/l) inhibited cytosolic Ca2+ signals triggered by high Ca2+ or Ni2+. Nickel(2+) 102-106 interleukin 6 Homo sapiens 14-18 9740146-10 1998 TPA (10 nmol/L) also stimulated the production of IL-6 and IL-8 by these cells, but inhibited that of monocyte chemoattractant protein-1. Tetradecanoylphorbol Acetate 0-3 interleukin 6 Homo sapiens 50-54 9840004-8 1998 Increased IL-6 levels were observed in cultures exposed to copper (5-19-fold compared to untreated controls), zinc (16-fold), cobalt (12-fold), nickel (10-fold) and palladium (4-fold). Copper 59-65 interleukin 6 Homo sapiens 10-14 9840004-8 1998 Increased IL-6 levels were observed in cultures exposed to copper (5-19-fold compared to untreated controls), zinc (16-fold), cobalt (12-fold), nickel (10-fold) and palladium (4-fold). Palladium 165-174 interleukin 6 Homo sapiens 10-14 9767285-9 1998 The production of IL-1 alpha/IL-6 was inhibited up to 80/89% (10-7-10-6 mol/L before and after irradiation) by dexamethasone in a concentration-dependent manner and with all conditions of incubation. Dexamethasone 111-124 interleukin 6 Homo sapiens 29-33 9734662-7 1998 Effects of RA + DEX were also least able to be overcome by exogenous IL-6. Dexamethasone 16-19 interleukin 6 Homo sapiens 69-73 9734662-9 1998 Since RPMI 8226 cells have undetectable IL-6, we investigated U266B1 cells and found that RA and DEX decreased both IL-6 secretion and IL-6 RNA levels. Dexamethasone 97-100 interleukin 6 Homo sapiens 40-44 9734662-9 1998 Since RPMI 8226 cells have undetectable IL-6, we investigated U266B1 cells and found that RA and DEX decreased both IL-6 secretion and IL-6 RNA levels. Dexamethasone 97-100 interleukin 6 Homo sapiens 116-120 9734662-9 1998 Since RPMI 8226 cells have undetectable IL-6, we investigated U266B1 cells and found that RA and DEX decreased both IL-6 secretion and IL-6 RNA levels. Dexamethasone 97-100 interleukin 6 Homo sapiens 116-120 9734662-10 1998 Mechanistically, IL-6R down-regulation by RA was enhanced by DEX, whereas IL-6 protein and RNA levels were reduced by DEX and by RA. Dexamethasone 61-64 interleukin 6 Homo sapiens 17-21 9734662-11 1998 In summary, combinations of RA + DEX were not only more effective in inhibiting myeloma cells growth by the dual mechanisms of decreasing proliferative fraction and increasing apoptotic fraction, but were also less able to be overcome by IL-6. Dexamethasone 33-36 interleukin 6 Homo sapiens 238-242 9734662-0 1998 Dexamethasone plus retinoids decrease IL-6/IL-6 receptor and induce apoptosis in myeloma cells. Dexamethasone 0-13 interleukin 6 Homo sapiens 38-42 9734662-0 1998 Dexamethasone plus retinoids decrease IL-6/IL-6 receptor and induce apoptosis in myeloma cells. Dexamethasone 0-13 interleukin 6 Homo sapiens 43-47 9785043-3 1998 The functions of these intrapituitary cytokines, principally IL-6, are discussed in the context of potential regulation of the pituitary-adrenal axis (ACTH secretion) via intrapituitary PGE2 generation during the acute-phase response to infectious/inflammatory stimuli. Dinoprostone 186-190 interleukin 6 Homo sapiens 61-65 9754553-5 1998 Furthermore, imCH-11 induced IL-2 and IL-6 mRNA expression. imch-11 13-20 interleukin 6 Homo sapiens 38-42 9768909-5 1998 The IL-6 level was not significantly altered, but was higher in patients with TiAIV prostheses than in those with a CrCoMo implant and in patients with cemented prostheses. tiaiv 78-83 interleukin 6 Homo sapiens 4-8 9891902-7 1998 RESULTS: Tretinoin showed very potent inhibition of PMA-stimulated IL-6 (interleukin 6) release by A431 cells. Tretinoin 9-18 interleukin 6 Homo sapiens 67-71 9725254-3 1998 Studies of cytokine production over 6 to 24 h demonstrated that IL-6 and GM-CSF release from both cell types were inhibited by brefeldin A (BFA) following activation with calcium ionophore, A23187. Calcium 171-178 interleukin 6 Homo sapiens 64-68 9891902-7 1998 RESULTS: Tretinoin showed very potent inhibition of PMA-stimulated IL-6 (interleukin 6) release by A431 cells. Tretinoin 9-18 interleukin 6 Homo sapiens 73-86 9747588-4 1998 The results of this research show a dual effect on the production/release of inflammatory mediators: the synthesis of the proinflammatory cytokine interleukin-6 becomes strongly inhibited at photosensitizer concentrations that clearly stimulate the production of prostaglandins (PGE2) by skin cells. Prostaglandins 263-277 interleukin 6 Homo sapiens 147-160 9732406-0 1998 EP4/EP2 receptor-specific prostaglandin E2 regulation of interleukin-6 generation by human HSB.2 early T cells. Dinoprostone 26-42 interleukin 6 Homo sapiens 57-70 9732406-3 1998 We now show that PGE2 and the EP4/EP2/EP3 R-selective agonist misoprostol, but not the EP3 R-directed agonists sulprostone and M&B28767, induced increases in HSB.2 T cell interleukin-6 (IL-6) mRNA and secretion. Dinoprostone 17-21 interleukin 6 Homo sapiens 175-188 9732406-3 1998 We now show that PGE2 and the EP4/EP2/EP3 R-selective agonist misoprostol, but not the EP3 R-directed agonists sulprostone and M&B28767, induced increases in HSB.2 T cell interleukin-6 (IL-6) mRNA and secretion. Dinoprostone 17-21 interleukin 6 Homo sapiens 190-194 9732406-4 1998 Pharmacological agents that increase intracellular concentration of cyclic AMP ([cAMP]i) mimicked and synergistically enhanced induction of IL-6 secretion by PGE2, whereas inhibitors of protein kinase A (PKA) but not protein kinase C suppressed PGE2-evoked increases in IL-6 secretion, suggesting that cAMP and PKA are the intracellular messengers of the PGE2 effect. Cyclic AMP 68-78 interleukin 6 Homo sapiens 140-144 9732406-4 1998 Pharmacological agents that increase intracellular concentration of cyclic AMP ([cAMP]i) mimicked and synergistically enhanced induction of IL-6 secretion by PGE2, whereas inhibitors of protein kinase A (PKA) but not protein kinase C suppressed PGE2-evoked increases in IL-6 secretion, suggesting that cAMP and PKA are the intracellular messengers of the PGE2 effect. Cyclic AMP 68-78 interleukin 6 Homo sapiens 270-274 9732406-4 1998 Pharmacological agents that increase intracellular concentration of cyclic AMP ([cAMP]i) mimicked and synergistically enhanced induction of IL-6 secretion by PGE2, whereas inhibitors of protein kinase A (PKA) but not protein kinase C suppressed PGE2-evoked increases in IL-6 secretion, suggesting that cAMP and PKA are the intracellular messengers of the PGE2 effect. Cyclic AMP 81-85 interleukin 6 Homo sapiens 140-144 9732406-4 1998 Pharmacological agents that increase intracellular concentration of cyclic AMP ([cAMP]i) mimicked and synergistically enhanced induction of IL-6 secretion by PGE2, whereas inhibitors of protein kinase A (PKA) but not protein kinase C suppressed PGE2-evoked increases in IL-6 secretion, suggesting that cAMP and PKA are the intracellular messengers of the PGE2 effect. Cyclic AMP 81-85 interleukin 6 Homo sapiens 270-274 9732406-4 1998 Pharmacological agents that increase intracellular concentration of cyclic AMP ([cAMP]i) mimicked and synergistically enhanced induction of IL-6 secretion by PGE2, whereas inhibitors of protein kinase A (PKA) but not protein kinase C suppressed PGE2-evoked increases in IL-6 secretion, suggesting that cAMP and PKA are the intracellular messengers of the PGE2 effect. Dinoprostone 158-162 interleukin 6 Homo sapiens 140-144 9732406-4 1998 Pharmacological agents that increase intracellular concentration of cyclic AMP ([cAMP]i) mimicked and synergistically enhanced induction of IL-6 secretion by PGE2, whereas inhibitors of protein kinase A (PKA) but not protein kinase C suppressed PGE2-evoked increases in IL-6 secretion, suggesting that cAMP and PKA are the intracellular messengers of the PGE2 effect. Dinoprostone 245-249 interleukin 6 Homo sapiens 140-144 9732406-4 1998 Pharmacological agents that increase intracellular concentration of cyclic AMP ([cAMP]i) mimicked and synergistically enhanced induction of IL-6 secretion by PGE2, whereas inhibitors of protein kinase A (PKA) but not protein kinase C suppressed PGE2-evoked increases in IL-6 secretion, suggesting that cAMP and PKA are the intracellular messengers of the PGE2 effect. Cyclic AMP 302-306 interleukin 6 Homo sapiens 140-144 9732406-4 1998 Pharmacological agents that increase intracellular concentration of cyclic AMP ([cAMP]i) mimicked and synergistically enhanced induction of IL-6 secretion by PGE2, whereas inhibitors of protein kinase A (PKA) but not protein kinase C suppressed PGE2-evoked increases in IL-6 secretion, suggesting that cAMP and PKA are the intracellular messengers of the PGE2 effect. Dinoprostone 245-249 interleukin 6 Homo sapiens 140-144 9732406-6 1998 Con A-stimulated HSB.2 T cells responded to PGE2 with greater increases in IL-6 mRNA and secretion of IL-6. Dinoprostone 44-48 interleukin 6 Homo sapiens 75-79 9732406-6 1998 Con A-stimulated HSB.2 T cells responded to PGE2 with greater increases in IL-6 mRNA and secretion of IL-6. Dinoprostone 44-48 interleukin 6 Homo sapiens 102-106 9732406-8 1998 Therefore, EP4 and EP2 Rs mediate PGE2-induced increases in IL-6 secretion by HSB.2 T cells through a transcriptional and cAMP dependent-mechanism. Dinoprostone 34-38 interleukin 6 Homo sapiens 60-64 9732406-8 1998 Therefore, EP4 and EP2 Rs mediate PGE2-induced increases in IL-6 secretion by HSB.2 T cells through a transcriptional and cAMP dependent-mechanism. Cyclic AMP 122-126 interleukin 6 Homo sapiens 60-64 9732406-9 1998 The increased ratio of EP4 Rs/EP3 Rs may contribute to Con A enhancement of PGE2-elicited increases in IL-6 secretion by HSB.2 T cells. Dinoprostone 76-80 interleukin 6 Homo sapiens 103-107 9747588-4 1998 The results of this research show a dual effect on the production/release of inflammatory mediators: the synthesis of the proinflammatory cytokine interleukin-6 becomes strongly inhibited at photosensitizer concentrations that clearly stimulate the production of prostaglandins (PGE2) by skin cells. Dinoprostone 279-283 interleukin 6 Homo sapiens 147-160 9763305-0 1998 Histamine enhances UVB-induced IL-6 production by human keratinocytes. Histamine 0-9 interleukin 6 Homo sapiens 31-35 9731855-5 1998 RESULTS: Culture in the presence of ethanol, lipopolysaccharide, or lipopolysaccharide and ethanol resulted in the increased transcription and secretion of granulocyte colony-stimulating factor, regulated on activation normal T cell expressed and secreted, and interleukin-6 at significantly greater levels (P < .01) than control cultures. Ethanol 36-43 interleukin 6 Homo sapiens 261-274 9731855-5 1998 RESULTS: Culture in the presence of ethanol, lipopolysaccharide, or lipopolysaccharide and ethanol resulted in the increased transcription and secretion of granulocyte colony-stimulating factor, regulated on activation normal T cell expressed and secreted, and interleukin-6 at significantly greater levels (P < .01) than control cultures. Ethanol 91-98 interleukin 6 Homo sapiens 261-274 9825023-0 1998 Serotonin-immune interactions in elderly volunteers and in patients with Alzheimer"s disease (DAT): lower plasma tryptophan availability to the brain in the elderly and increased serum interleukin-6 in DAT. Serotonin 0-9 interleukin 6 Homo sapiens 185-198 9712900-5 1998 By measuring cellular responses, such as morphological changes upon differentiation, soft agar colony formation, and induction of tyrosine phosphorylation of the signal transducer and activator of transcription, STAT3, we show that signaling by IL-6, but not LIF, is significantly reduced by mutations in the Ig-like module of gp130. Tyrosine 130-138 interleukin 6 Homo sapiens 245-249 10921031-5 1998 During ATRA treatment, serum IL-6 changes were correlated with WBC changes. Tretinoin 7-11 interleukin 6 Homo sapiens 29-33 10921031-8 1998 CONCLUSION: Serum levels of IL-6, sgp130, IL-8 may reflect patient"s responsiveness to ATRA treatment, predict hyperleukocytosis and intercurrent infection. Tretinoin 87-91 interleukin 6 Homo sapiens 28-32 9825023-6 1998 The results suggest that: 1) in normal humans, the availability of plasma tryptophan to the brain decreases with age, and with activation of the immune system; and 2) increased production of IL-6 may play a role in the pathogenesis of DAT. Tryptophan 74-84 interleukin 6 Homo sapiens 191-195 9687383-1 1998 We show that the coumeromycin antibiotic novobiocin, a potent inhibitor of ADP ribosylation, prevents lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF-alpha), interleukin-1 (IL-1), IL-6, and IL-10 secretion in human peripheral blood mononuclear cells. Novobiocin 41-51 interleukin 6 Homo sapiens 198-202 9763305-4 1998 Histamine weakly stimulated IL-6 production by itself. Histamine 0-9 interleukin 6 Homo sapiens 28-32 9763305-10 1998 These results show that histamine augments UVB-induced IL-6 production by keratinocytes predominantly via the H1 receptor at the level of transcription. Histamine 24-33 interleukin 6 Homo sapiens 55-59 9712106-0 1998 Nitric oxide downregulates interleukin 1beta (IL-1beta) stimulated IL-6, IL-8, and prostaglandin E2 production by human chondrocytes. Nitric Oxide 0-12 interleukin 6 Homo sapiens 67-71 9712551-1 1998 PURPOSE: To investigate the molecular mechanisms of the radioprotective effect of the Bowman-Birk proteinase inhibitor (BBI) in normal human skin fibroblasts (HSF). Amiodarone 120-123 interleukin 6 Homo sapiens 159-162 9712551-3 1998 RESULTS: As indicated by time-course experiments based on clonogenic assays, a 6 h pre-incubation with BBI before irradiation of HSF with a single dose of 6 Gy resulted in maximum radioprotection. Amiodarone 103-106 interleukin 6 Homo sapiens 129-132 9703288-0 1998 Interleukin 6 is a cause of flu-like symptoms in treatment with a deoxycytidine analogue. Deoxycytidine 66-79 interleukin 6 Homo sapiens 0-13 9703288-2 1998 This study demonstrated a strong correlation between plasma interleukin 6 levels and fever in treatment with oral (E)-2"-deoxy-2"(fluoromethylene)cytidine, another deoxycytidine analogue. tezacitabine 114-154 interleukin 6 Homo sapiens 60-73 9703288-2 1998 This study demonstrated a strong correlation between plasma interleukin 6 levels and fever in treatment with oral (E)-2"-deoxy-2"(fluoromethylene)cytidine, another deoxycytidine analogue. Deoxycytidine 164-177 interleukin 6 Homo sapiens 60-73 9826026-6 1998 Thus another activity of NaBu in addition to the inhibition of histone deacetylase may be involved in promoting IL-6-induced differentiation. sethoxydim 25-29 interleukin 6 Homo sapiens 112-116 9712106-9 1998 Inhibition of NO synthesis with the competitive inhibitor NG-monomethyl-L-arginine (L-NMMA) led to enhancement of IL-6, IL-8, and PGE2 production stimulated by either IL-1beta alone or in combination with LPS, whereas the inhibition of proteoglycan production by IL-1beta was not modified by L-NMMA. omega-N-Methylarginine 58-82 interleukin 6 Homo sapiens 114-118 9712106-9 1998 Inhibition of NO synthesis with the competitive inhibitor NG-monomethyl-L-arginine (L-NMMA) led to enhancement of IL-6, IL-8, and PGE2 production stimulated by either IL-1beta alone or in combination with LPS, whereas the inhibition of proteoglycan production by IL-1beta was not modified by L-NMMA. omega-N-Methylarginine 84-90 interleukin 6 Homo sapiens 114-118 9776474-9 1998 In contrast, dexamethasone inhibited markedly the expression of all cytokines tested (IL-2, IL-4, IL-6, IL-10, IFN-gamma and TNF-alpha) in dose-dependent fashion, reducing levels to near to background. Dexamethasone 13-26 interleukin 6 Homo sapiens 98-102 9715184-20 1998 Perflubron exhibits an anti-inflammatory effect in the alveolar environment with reduction of proinflammatory IL-1 and IL-6 (possibly removing a stimulus for IL-10), white blood cell count, and protein capillary leak. perflubron 0-10 interleukin 6 Homo sapiens 119-123 9742554-7 1998 In lyophilizates containing a crystallized excipient such as glycine or mannitol, IL-6 suffered destabilization, which was less pronounced if an additional amorphous excipient was present. Glycine 61-68 interleukin 6 Homo sapiens 82-86 9669431-3 1998 Here we report the results from a 900-day prospective study designed to determine whether tumor necrosis factor-alfa (TNF-alpha) and interleukin-6 (IL-6) predict serum albumin and cholesterol levels and mortality in a group of 90 ambulatory, adult hemodialysis patients with no acute infection, hospitalization or surgery, and no known acquired immunodeficiency syndrome (AIDS), malignancy, or liver disease. Cholesterol 180-191 interleukin 6 Homo sapiens 148-152 9639523-1 1998 The mechanism by which interleukin-6 (IL-6) protects multiple myeloma (MM) plasma cells from apoptosis induced by anti-fas antibodies and dexamethasone was studied. Dexamethasone 138-151 interleukin 6 Homo sapiens 23-36 9639523-1 1998 The mechanism by which interleukin-6 (IL-6) protects multiple myeloma (MM) plasma cells from apoptosis induced by anti-fas antibodies and dexamethasone was studied. Dexamethasone 138-151 interleukin 6 Homo sapiens 38-42 9639523-3 1998 However, IL-6-dependent protection of viability correlated with an inhibition of dexamethasone- and anti-fas-induced activation of jun kinase (JNK) and AP-1 transactivation. Dexamethasone 81-94 interleukin 6 Homo sapiens 9-13 9657134-6 1998 These data may explain the palliative efficacy of Dex treatment and provide a rationale for combining IL-6 antagonists with Dex to overcome the IL-6-mediated resistance of immature tumor cells. Dexamethasone 124-127 interleukin 6 Homo sapiens 144-148 9652857-0 1998 Suppression of heat-induced HSF activation by CDDP in human glioblastoma cells. cddp 46-50 interleukin 6 Homo sapiens 28-31 9652857-4 1998 This was due to the p53-dependent inhibition of heat-induced HSF activation by CDDP. cddp 79-83 interleukin 6 Homo sapiens 61-64 9692957-1 1998 A noncovalently bound dimeric form of recombinant human IL-6 interleukin-6 (IL-6D) was shown to be an antagonist for IL-6 activity, in a STAT3 tyrosine phosphorylation assay using HepG2 cells, under conditions where it does not dissociate into monomeric IL-6 (IL-6M). Tyrosine 143-151 interleukin 6 Homo sapiens 56-60 9692957-1 1998 A noncovalently bound dimeric form of recombinant human IL-6 interleukin-6 (IL-6D) was shown to be an antagonist for IL-6 activity, in a STAT3 tyrosine phosphorylation assay using HepG2 cells, under conditions where it does not dissociate into monomeric IL-6 (IL-6M). Tyrosine 143-151 interleukin 6 Homo sapiens 61-74 9692957-1 1998 A noncovalently bound dimeric form of recombinant human IL-6 interleukin-6 (IL-6D) was shown to be an antagonist for IL-6 activity, in a STAT3 tyrosine phosphorylation assay using HepG2 cells, under conditions where it does not dissociate into monomeric IL-6 (IL-6M). Tyrosine 143-151 interleukin 6 Homo sapiens 76-80 9692957-1 1998 A noncovalently bound dimeric form of recombinant human IL-6 interleukin-6 (IL-6D) was shown to be an antagonist for IL-6 activity, in a STAT3 tyrosine phosphorylation assay using HepG2 cells, under conditions where it does not dissociate into monomeric IL-6 (IL-6M). Tyrosine 143-151 interleukin 6 Homo sapiens 76-80 9692957-2 1998 The fluorescence from Trp157, the single tryptophan residue in the primary sequence of IL-6, is altered in IL-6D, where the wavelength maximum is blue-shifted by 3 nm and the emission intensity is reduced by 30%. Tryptophan 41-51 interleukin 6 Homo sapiens 87-91 9692957-4 1998 Both IL-6D and IL-6M are compact molecules, as determined by sedimentation velocity analysis, and contain essentially identical levels of secondary and tertiary structure, as determined by far- and near-UV CD, respectively. Cadmium 206-208 interleukin 6 Homo sapiens 15-20 9692957-5 1998 IL-6D and IL-6M show the same susceptibility to limited proteolytic attack, and exhibit identical far-UV CD-monitored urea-denaturation profiles with the midpoint of denaturation occurring at 6.0 +/- 0.1 M urea. Cadmium 105-107 interleukin 6 Homo sapiens 10-15 9692957-5 1998 IL-6D and IL-6M show the same susceptibility to limited proteolytic attack, and exhibit identical far-UV CD-monitored urea-denaturation profiles with the midpoint of denaturation occurring at 6.0 +/- 0.1 M urea. Urea 118-122 interleukin 6 Homo sapiens 10-15 9692957-5 1998 IL-6D and IL-6M show the same susceptibility to limited proteolytic attack, and exhibit identical far-UV CD-monitored urea-denaturation profiles with the midpoint of denaturation occurring at 6.0 +/- 0.1 M urea. Urea 206-210 interleukin 6 Homo sapiens 10-15 9651185-8 1998 The IL-6 response was inhibited by the metal chelator deferoxamine and the free radical scavenger N-acetyl-L-cysteine, suggesting that the activation of NF-kappaB may be mediated through reactive oxygen intermediates generated by transition metals found in ROFA. Acetylcysteine 98-117 interleukin 6 Homo sapiens 4-8 9651185-8 1998 The IL-6 response was inhibited by the metal chelator deferoxamine and the free radical scavenger N-acetyl-L-cysteine, suggesting that the activation of NF-kappaB may be mediated through reactive oxygen intermediates generated by transition metals found in ROFA. Oxygen 196-202 interleukin 6 Homo sapiens 4-8 9649471-9 1998 RESULTS: After 24 hours of EtOH exposure, the release of IL-1 alpha doubled, that of IL-6 increased 10 times, and that of TNF-alpha increased 3.5 times. Ethanol 27-31 interleukin 6 Homo sapiens 85-89 9647240-5 1998 Despite a reduction in IL-6-induced STAT3 DNA binding activity in the nuclear compartment during STAT-masking, there was increased and prolonged accumulation of tyrosine-phosphorylated STAT3 in both the cytoplasmic and nuclear compartments, indicating that the capacity of tyrosine-phosphorylated STAT3 to bind DNA was reduced during STAT-masking. Tyrosine 161-169 interleukin 6 Homo sapiens 23-27 9693575-7 1998 Significant levels of IL-6 were produced by cells stimulated with Escherichia coli lipopolysaccharide B5 (933 pg/ml/10(7) neutrophils) and E. coli lipopolysaccharide B12 (791 pg/ml/10(7) neutrophils) when compared with unstimulated cells (39.31 pg/ml/10(7) cells). lipopolysaccharide b12 147-169 interleukin 6 Homo sapiens 22-26 9647240-5 1998 Despite a reduction in IL-6-induced STAT3 DNA binding activity in the nuclear compartment during STAT-masking, there was increased and prolonged accumulation of tyrosine-phosphorylated STAT3 in both the cytoplasmic and nuclear compartments, indicating that the capacity of tyrosine-phosphorylated STAT3 to bind DNA was reduced during STAT-masking. Tyrosine 273-281 interleukin 6 Homo sapiens 23-27 9749865-6 1998 Hydrocortisone significantly suppressed the production of IL-6, IL-8, and GM-CSF by TCCs from AH of VKH patients. Hydrocortisone 0-14 interleukin 6 Homo sapiens 58-62 9648083-9 1998 The concentration of IL-6 in the supernatant of stimulated monocytes was highest with Glu/Bic (1023 +/- 278 pg/ml) and Amino/Bic (776 +/- 296 pg/ml) an lowest with Glu/lac pH 5.5 (46 +/- 22 pg/ml) and Glu-poly/PBS (32 +/- 13 pg/ml). Glucose 86-89 interleukin 6 Homo sapiens 21-25 9648083-9 1998 The concentration of IL-6 in the supernatant of stimulated monocytes was highest with Glu/Bic (1023 +/- 278 pg/ml) and Amino/Bic (776 +/- 296 pg/ml) an lowest with Glu/lac pH 5.5 (46 +/- 22 pg/ml) and Glu-poly/PBS (32 +/- 13 pg/ml). Bicarbonates 90-93 interleukin 6 Homo sapiens 21-25 9648083-9 1998 The concentration of IL-6 in the supernatant of stimulated monocytes was highest with Glu/Bic (1023 +/- 278 pg/ml) and Amino/Bic (776 +/- 296 pg/ml) an lowest with Glu/lac pH 5.5 (46 +/- 22 pg/ml) and Glu-poly/PBS (32 +/- 13 pg/ml). Bicarbonates 125-128 interleukin 6 Homo sapiens 21-25 9648083-9 1998 The concentration of IL-6 in the supernatant of stimulated monocytes was highest with Glu/Bic (1023 +/- 278 pg/ml) and Amino/Bic (776 +/- 296 pg/ml) an lowest with Glu/lac pH 5.5 (46 +/- 22 pg/ml) and Glu-poly/PBS (32 +/- 13 pg/ml). Glucose 164-167 interleukin 6 Homo sapiens 21-25 9648083-9 1998 The concentration of IL-6 in the supernatant of stimulated monocytes was highest with Glu/Bic (1023 +/- 278 pg/ml) and Amino/Bic (776 +/- 296 pg/ml) an lowest with Glu/lac pH 5.5 (46 +/- 22 pg/ml) and Glu-poly/PBS (32 +/- 13 pg/ml). Glucose 164-167 interleukin 6 Homo sapiens 21-25 9712363-5 1998 Using reverse-transcriptase polymerase chain reaction (RT-PCR) and ELISA respectively, we demonstrate further that levels of 17beta-estradiol (active metabolite of estrogen) > or = those found in serum of estrogen-sufficient women inhibit steady-state IL-6 mRNA levels as well as inhibit secretion of IL-6 into culture supernatants. Estradiol 125-141 interleukin 6 Homo sapiens 255-259 9712363-5 1998 Using reverse-transcriptase polymerase chain reaction (RT-PCR) and ELISA respectively, we demonstrate further that levels of 17beta-estradiol (active metabolite of estrogen) > or = those found in serum of estrogen-sufficient women inhibit steady-state IL-6 mRNA levels as well as inhibit secretion of IL-6 into culture supernatants. Estradiol 125-141 interleukin 6 Homo sapiens 304-308 9706856-0 1998 Crevicular fluid interleukin-1beta, tumor necrosis factor-alpha, and interleukin-6 levels in renal transplant patients receiving cyclosporine A. Cyclosporine 129-143 interleukin 6 Homo sapiens 69-82 9738983-8 1998 Platinum compounds induced cytokine production in human EC: cisplatin most prominently induced the release of IL-1 and IL-6, and TRK-710 had the greatest ability to induce the release of GM-CSF. Platinum 0-8 interleukin 6 Homo sapiens 119-123 9738983-8 1998 Platinum compounds induced cytokine production in human EC: cisplatin most prominently induced the release of IL-1 and IL-6, and TRK-710 had the greatest ability to induce the release of GM-CSF. Cisplatin 60-69 interleukin 6 Homo sapiens 119-123 11061332-2 1998 It has been recently shown that glucose can induce the synthesis of TNF and IL-6 in human monocytes. Glucose 32-39 interleukin 6 Homo sapiens 76-80 10070569-4 1998 Results showed that a 48 h O2 exposure was associated with two distinct patterns of response: a decrease in TNF-alpha, IL-1 beta and IL-6 expression, and an increase in IL-8. Oxygen 27-29 interleukin 6 Homo sapiens 133-137 10070569-6 1998 We confirmed that a 48 h O2 exposure led to similar changes with a decrease in TNF-alpha, IL-1 beta and IL-6 production and an increase in IL-8. Oxygen 25-27 interleukin 6 Homo sapiens 104-108 10070569-7 1998 Interestingly, this cytokine response was preceded during the first hours of O2 treatment by induction of TNF-alpha, IL-1 beta and IL-6. Oxygen 77-79 interleukin 6 Homo sapiens 131-135 9629951-7 1998 There were significant and inverse relationships between the availability of plasma tryptophan and serum IL-1RA, IL-6 and IL-8. Tryptophan 84-94 interleukin 6 Homo sapiens 113-117 9672248-0 1998 Correlation between glutathione oxidation and trimerization of heat shock factor 1, an early step in stress induction of the Hsp response. Glutathione 20-31 interleukin 6 Homo sapiens 63-80 9672248-6 1998 Presumably, thiol adduction and cross-linking would affect the structure of proteins involved, resulting in unfolding of a fraction of these proteins, causing heat shock factor (Hsf) activation. Sulfhydryl Compounds 12-17 interleukin 6 Homo sapiens 159-176 9672248-6 1998 Presumably, thiol adduction and cross-linking would affect the structure of proteins involved, resulting in unfolding of a fraction of these proteins, causing heat shock factor (Hsf) activation. Sulfhydryl Compounds 12-17 interleukin 6 Homo sapiens 178-181 9669002-8 1998 An inverse correlation was found between IL-6 plasma concentrations at one hour post-CPB and plasma cholesterol concentrations (r = -0.592, P = 0.02), high density lipoprotein (r = -0.595, P = 0.02), and low density lipoprotein (r = -0.656, P = 0.01). Cholesterol 100-111 interleukin 6 Homo sapiens 41-45 9620283-2 1998 Several investigators have recently reported that ATRA downregulates the production of interleukin-6 (IL-6) and the expression of IL-6 receptor (IL-6R) and also inhibits the proliferation of myeloma cells. Tretinoin 50-54 interleukin 6 Homo sapiens 87-100 9620283-2 1998 Several investigators have recently reported that ATRA downregulates the production of interleukin-6 (IL-6) and the expression of IL-6 receptor (IL-6R) and also inhibits the proliferation of myeloma cells. Tretinoin 50-54 interleukin 6 Homo sapiens 102-106 9626133-0 1998 Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence. Dehydroepiandrosterone Sulfate 40-52 interleukin 6 Homo sapiens 90-103 9626133-0 1998 Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence. Dehydroepiandrosterone Sulfate 40-52 interleukin 6 Homo sapiens 105-109 9660250-0 1998 Serotonin derivative, N-(p-coumaroyl) serotonin, inhibits the production of TNF-alpha, IL-1alpha, IL-1beta, and IL-6 by endotoxin-stimulated human blood monocytes. Serotonin 0-9 interleukin 6 Homo sapiens 112-116 9607842-4 1998 The effects of C3a and C3a(des)Arg on IL-6 gene expression and protein production in human peripheral blood mononuclear cells (PBMC) were investigated. Arginine 31-34 interleukin 6 Homo sapiens 38-42 9607842-6 1998 However, C3a and C3a(des)Arg affected endotoxin-induced IL-6 synthesis in a dose-dependent manner. Arginine 25-28 interleukin 6 Homo sapiens 56-60 9607842-7 1998 In nonadherent PBMC, C3a or C3a(des)Arg suppressed, while in adherent PBMC, C3a or C3a(des)Arg enhanced IL-6 protein and mRNA levels. Arginine 91-94 interleukin 6 Homo sapiens 104-108 9607842-8 1998 These results suggest that C3a and C3a(des)Arg may provide a control mechanism of acute-phase responses by enhancing IL-6 synthesis in adherent monocytes at local inflammatory sites and by inhibiting IL-6 synthesis in circulating monocytes. Arginine 43-46 interleukin 6 Homo sapiens 117-121 9607842-8 1998 These results suggest that C3a and C3a(des)Arg may provide a control mechanism of acute-phase responses by enhancing IL-6 synthesis in adherent monocytes at local inflammatory sites and by inhibiting IL-6 synthesis in circulating monocytes. Arginine 43-46 interleukin 6 Homo sapiens 200-204 9593038-3 1998 The combination of GBS and lactate also enhanced the secretion of interleukin (IL)-1beta and IL-6. Lactic Acid 27-34 interleukin 6 Homo sapiens 93-97 9718719-5 1998 Melatonin has also been reported to enhance the production of interleukin-6 from human monocytes. Melatonin 0-9 interleukin 6 Homo sapiens 62-75 9629251-3 1998 Sex steroids inhibit the expression of the genes encoding IL-6, gp80, and gp130, most likely by repressing the activity of transcription factors such as NF kappa B and NF-IL-6. Steroids 4-12 interleukin 6 Homo sapiens 58-62 9744754-4 1998 Oligonucleotide target probe sets were designed for several human cytokines, including TNFalpha, IL-2, IL-4, IL-6, IL-10, and IFNgamma. Oligonucleotides 0-15 interleukin 6 Homo sapiens 109-113 9625031-6 1998 RESULTS: An interesting effect on proinflammatory monokines was observed: in this study, we demonstrate that the calcium antagonist diltiazem enhances interleukin-1beta and slightly reduces interleukin-6 production in MLC, but it has no effect on tumor necrosis factor-alpha levels. Calcium 113-120 interleukin 6 Homo sapiens 190-203 9610391-4 1998 Indeed, previous studies by other investigators have shown that raising Ca2+o either in vivo or in vitro stimulated the release of interleukin-6 (IL-6) from human peripheral blood monocytes, suggesting that these cells express a Ca2+o-sensing mechanism. ca2+o 72-77 interleukin 6 Homo sapiens 131-144 9610391-4 1998 Indeed, previous studies by other investigators have shown that raising Ca2+o either in vivo or in vitro stimulated the release of interleukin-6 (IL-6) from human peripheral blood monocytes, suggesting that these cells express a Ca2+o-sensing mechanism. ca2+o 72-77 interleukin 6 Homo sapiens 146-150 9610391-4 1998 Indeed, previous studies by other investigators have shown that raising Ca2+o either in vivo or in vitro stimulated the release of interleukin-6 (IL-6) from human peripheral blood monocytes, suggesting that these cells express a Ca2+o-sensing mechanism. ca2+o 229-234 interleukin 6 Homo sapiens 131-144 9610391-4 1998 Indeed, previous studies by other investigators have shown that raising Ca2+o either in vivo or in vitro stimulated the release of interleukin-6 (IL-6) from human peripheral blood monocytes, suggesting that these cells express a Ca2+o-sensing mechanism. ca2+o 229-234 interleukin 6 Homo sapiens 146-150 9590694-3 1998 Here we show that treatment of the prostate cancer cell line LNCaP with IL-6 induces tyrosine phosphorylation of ErbB2 and ErbB3, but not ErbB1/EGFR. Tyrosine 85-93 interleukin 6 Homo sapiens 72-76 9657419-3 1998 There were significant correlations between the availability of tryptophan to the brain and serum IL-6, IL-8 and IL-1RA (all negative) and CC16 (positive). Tryptophan 64-74 interleukin 6 Homo sapiens 98-102 9672141-0 1998 Influence of L-glutamic acid on binding of interleukin-1beta, tumour necrosis factor-alpha and interleukin-6 to HL-60 cells. Glutamic Acid 13-28 interleukin 6 Homo sapiens 95-108 9610741-6 1998 Upon stimulation with IL-6/sIL-6R, the gp130, cytoplasmic Janus kinases JAK1 and JAK2 were tyrosine phosphorylated. Tyrosine 91-99 interleukin 6 Homo sapiens 22-26 9623726-2 1998 Human interleukin-6 (IL-6) is a cytokine found to be increased in subacute thyroiditis, amiodarone-induced thyrotoxicosis, Graves" disease, and other thyroid destructive processes. Amiodarone 88-98 interleukin 6 Homo sapiens 6-19 9538169-6 1998 These data suggest that NSCLC patients with high levels of IL-6 have a worse clinical outcome and may manifest resistance to cisplatin chemotherapy. Cisplatin 125-134 interleukin 6 Homo sapiens 59-63 9623726-2 1998 Human interleukin-6 (IL-6) is a cytokine found to be increased in subacute thyroiditis, amiodarone-induced thyrotoxicosis, Graves" disease, and other thyroid destructive processes. Amiodarone 88-98 interleukin 6 Homo sapiens 21-25 29645246-0 1998 IL-6 antisense oligonucleotides inhibit the growth of choriocarcinoma cells in vitro: a possible intracellular autocrine growth mechanism mediated by IL-6. Oligonucleotides 15-31 interleukin 6 Homo sapiens 0-4 9571161-5 1998 Our studies show that morphine differentially modulates lipopolysaccharide (LPS) induced expression of IL-6 and TNF-alpha. Morphine 22-30 interleukin 6 Homo sapiens 103-107 9571161-6 1998 Nanomolar concentrations of morphine synergize with LPS and augment the secretion of both IL-6 and TNF-alpha. Morphine 28-36 interleukin 6 Homo sapiens 90-94 9571161-7 1998 However, at micromolar concentrations morphine inhibits LPS induced synthesis of IL-6 and TNF-alpha. Morphine 38-46 interleukin 6 Homo sapiens 81-85 9516148-10 1998 Experiments using antisense oligonucleotides showed that the clonal growth of KS-1 and BC-1 was nearly 100% inhibited by IL-6 antisense oligonucleotides (10 micromol/L), but not at all by either oligonucleotides (</=10 micromol/L) to IL-6 sense, IL-6 scrambled, viral IL-6 (vIL-6) antisense, or IL-10 antisense. Oligonucleotides 28-44 interleukin 6 Homo sapiens 121-125 9516148-10 1998 Experiments using antisense oligonucleotides showed that the clonal growth of KS-1 and BC-1 was nearly 100% inhibited by IL-6 antisense oligonucleotides (10 micromol/L), but not at all by either oligonucleotides (</=10 micromol/L) to IL-6 sense, IL-6 scrambled, viral IL-6 (vIL-6) antisense, or IL-10 antisense. Oligonucleotides 136-152 interleukin 6 Homo sapiens 121-125 9516148-10 1998 Experiments using antisense oligonucleotides showed that the clonal growth of KS-1 and BC-1 was nearly 100% inhibited by IL-6 antisense oligonucleotides (10 micromol/L), but not at all by either oligonucleotides (</=10 micromol/L) to IL-6 sense, IL-6 scrambled, viral IL-6 (vIL-6) antisense, or IL-10 antisense. Oligonucleotides 136-152 interleukin 6 Homo sapiens 237-241 9516148-10 1998 Experiments using antisense oligonucleotides showed that the clonal growth of KS-1 and BC-1 was nearly 100% inhibited by IL-6 antisense oligonucleotides (10 micromol/L), but not at all by either oligonucleotides (</=10 micromol/L) to IL-6 sense, IL-6 scrambled, viral IL-6 (vIL-6) antisense, or IL-10 antisense. Oligonucleotides 136-152 interleukin 6 Homo sapiens 237-241 9516148-10 1998 Experiments using antisense oligonucleotides showed that the clonal growth of KS-1 and BC-1 was nearly 100% inhibited by IL-6 antisense oligonucleotides (10 micromol/L), but not at all by either oligonucleotides (</=10 micromol/L) to IL-6 sense, IL-6 scrambled, viral IL-6 (vIL-6) antisense, or IL-10 antisense. Oligonucleotides 136-152 interleukin 6 Homo sapiens 237-241 9516148-10 1998 Experiments using antisense oligonucleotides showed that the clonal growth of KS-1 and BC-1 was nearly 100% inhibited by IL-6 antisense oligonucleotides (10 micromol/L), but not at all by either oligonucleotides (</=10 micromol/L) to IL-6 sense, IL-6 scrambled, viral IL-6 (vIL-6) antisense, or IL-10 antisense. Oligonucleotides 136-152 interleukin 6 Homo sapiens 121-125 9516148-10 1998 Experiments using antisense oligonucleotides showed that the clonal growth of KS-1 and BC-1 was nearly 100% inhibited by IL-6 antisense oligonucleotides (10 micromol/L), but not at all by either oligonucleotides (</=10 micromol/L) to IL-6 sense, IL-6 scrambled, viral IL-6 (vIL-6) antisense, or IL-10 antisense. Oligonucleotides 136-152 interleukin 6 Homo sapiens 237-241 9516148-10 1998 Experiments using antisense oligonucleotides showed that the clonal growth of KS-1 and BC-1 was nearly 100% inhibited by IL-6 antisense oligonucleotides (10 micromol/L), but not at all by either oligonucleotides (</=10 micromol/L) to IL-6 sense, IL-6 scrambled, viral IL-6 (vIL-6) antisense, or IL-10 antisense. Oligonucleotides 136-152 interleukin 6 Homo sapiens 237-241 9516148-10 1998 Experiments using antisense oligonucleotides showed that the clonal growth of KS-1 and BC-1 was nearly 100% inhibited by IL-6 antisense oligonucleotides (10 micromol/L), but not at all by either oligonucleotides (</=10 micromol/L) to IL-6 sense, IL-6 scrambled, viral IL-6 (vIL-6) antisense, or IL-10 antisense. Oligonucleotides 136-152 interleukin 6 Homo sapiens 237-241 9516148-11 1998 Furthermore, the IL-6 antisense oligonucleotides had no effect on two B-cell lymphoma cell lines, which were not infected with KSHV. Oligonucleotides 32-48 interleukin 6 Homo sapiens 17-21 9516148-13 1998 Taken together, we have defined the cytokines and their receptors expressed on PEL cells and have found that these cells synthesized IL-6 and IL-6 receptors; interruption of this pathway by IL-6 antisense oligonucleotides specifically prevented the growth of these cells. Oligonucleotides 205-221 interleukin 6 Homo sapiens 133-137 9516148-13 1998 Taken together, we have defined the cytokines and their receptors expressed on PEL cells and have found that these cells synthesized IL-6 and IL-6 receptors; interruption of this pathway by IL-6 antisense oligonucleotides specifically prevented the growth of these cells. Oligonucleotides 205-221 interleukin 6 Homo sapiens 142-146 9516148-13 1998 Taken together, we have defined the cytokines and their receptors expressed on PEL cells and have found that these cells synthesized IL-6 and IL-6 receptors; interruption of this pathway by IL-6 antisense oligonucleotides specifically prevented the growth of these cells. Oligonucleotides 205-221 interleukin 6 Homo sapiens 142-146 9563900-0 1998 Interleukin 6 differentially potentiates the antitumor effects of taxol and vinblastine in U266 human myeloma cells. Paclitaxel 66-71 interleukin 6 Homo sapiens 0-13 9563900-6 1998 In the presence of IL-6, the DNA distribution pattern induced by Taxol or vinblastine was altered. Paclitaxel 65-70 interleukin 6 Homo sapiens 19-23 9563900-7 1998 Whereas IL-6 augmented the sub-G1 fraction and G2-M phase for Taxol-treated cells, only the G2-M phase was increased for vinblastine-treated cells. Paclitaxel 62-67 interleukin 6 Homo sapiens 8-12 9563900-11 1998 In the presence of IL-6, the number of cells containing microtubule asters increased for Taxol treatment, but not for vinblastine treatment. Paclitaxel 89-94 interleukin 6 Homo sapiens 19-23 9563900-12 1998 These data indicate that IL-6 leads to differential modulation of the cytotoxicity of Taxol and vinblastine in U266 cells. Paclitaxel 86-91 interleukin 6 Homo sapiens 25-29 9563900-14 1998 Furthermore, our data suggest that the microtubule-associated form of mitogen-activated protein kinase may play a role in IL-6-mediated enhancement of the cytotoxicity of Taxol. Paclitaxel 171-176 interleukin 6 Homo sapiens 122-126 9563797-3 1998 The role of IL-6 in hypercalcemia and bone resorption would suggest that bisphosphonates or dexamethasone could be useful as adjuvant therapy for IL-6 dependent bone metastases which fail to respond to interferon alpha (IFN) alpha 2a and all trans retinoic acid (ATRA). Dexamethasone 92-105 interleukin 6 Homo sapiens 12-16 9563797-3 1998 The role of IL-6 in hypercalcemia and bone resorption would suggest that bisphosphonates or dexamethasone could be useful as adjuvant therapy for IL-6 dependent bone metastases which fail to respond to interferon alpha (IFN) alpha 2a and all trans retinoic acid (ATRA). Dexamethasone 92-105 interleukin 6 Homo sapiens 146-150 9566351-1 1998 The present studies demonstrate that histamine induces the secretion of IL-6, IL-8 and GM-CSF from human conjunctival epithelial cells in a dose- and time-dependent manner. Histamine 37-46 interleukin 6 Homo sapiens 72-76 9566351-3 1998 Emedastine potently inhibited histamine-induced IL-6, IL-8 and GM-CSF secretion with mean IC50 values of 2.23, 3.42 and 1.50 nM, respectively. Histamine 30-39 interleukin 6 Homo sapiens 48-52 29645246-0 1998 IL-6 antisense oligonucleotides inhibit the growth of choriocarcinoma cells in vitro: a possible intracellular autocrine growth mechanism mediated by IL-6. Oligonucleotides 15-31 interleukin 6 Homo sapiens 150-154 9600708-7 1998 In vitro reconstitution of the anti-sense treated cultures with synthetic met-enkephalin or the delta-type specific opioid receptor agonist deltorphin could reverse inhibition of monocyte IL-6 production, suggesting that endogenous enkephalins act via membrane opioid receptors. deltorphin 140-150 interleukin 6 Homo sapiens 188-192 9523575-0 1998 Substance P and histamine induce interleukin-6 expression in human astrocytoma cells by a mechanism involving protein kinase C and nuclear factor-IL-6. Histamine 16-25 interleukin 6 Homo sapiens 33-46 9523575-0 1998 Substance P and histamine induce interleukin-6 expression in human astrocytoma cells by a mechanism involving protein kinase C and nuclear factor-IL-6. Histamine 16-25 interleukin 6 Homo sapiens 146-150 9523575-1 1998 Interleukin-6 (IL-6) is a proinflammatory cytokine whose synthesis is induced by a variety of stimuli including interleukin-1 (IL-1), substance P (SP), and histamine. Histamine 156-165 interleukin 6 Homo sapiens 0-13 9523575-1 1998 Interleukin-6 (IL-6) is a proinflammatory cytokine whose synthesis is induced by a variety of stimuli including interleukin-1 (IL-1), substance P (SP), and histamine. Histamine 156-165 interleukin 6 Homo sapiens 15-19 9523575-4 1998 We therefore used human astrocytoma cells to search for signal transduction cascades and transcription factors whose inhibition suppresses IL-6 synthesis after stimulation with three different inductors, IL-1beta, SP, and histamine. Histamine 222-231 interleukin 6 Homo sapiens 139-143 9523575-6 1998 Promoter deletion analysis revealed that IL-1beta-induced IL-6 expression required the transcription factor nuclear factor-kappaB (NF-kappaB), whereas SP- and histamine-induced IL-6 synthesis was essentially controlled by NF-IL-6. Histamine 159-168 interleukin 6 Homo sapiens 177-181 9618706-6 1998 Moreover, histamine induces a significant increase of IL-6 and IL-8 secretion by EC. Histamine 10-19 interleukin 6 Homo sapiens 54-58 9695746-4 1998 Previous investigations of PMN release of reactive oxygen species demonstrate that IL-6 in concert with other mediators may augment cytotoxicity. Reactive Oxygen Species 42-65 interleukin 6 Homo sapiens 83-87 9699868-0 1998 Regulation of sex steroid formation by interleukin-4 and interleukin-6 in breast cancer cells. Steroids 18-25 interleukin 6 Homo sapiens 57-70 9699868-11 1998 Moreover, IL-4 and IL-6 exerted the same regulatory effects on 17beta-HSD activities when testosterone and 4-dione were used as substrates, thus strongly suggesting the expression of the type 2 17beta-HSD ZR-75-1 cells. Testosterone 90-102 interleukin 6 Homo sapiens 19-23 9506738-5 1998 Culture of adipose tissue fragments for 7 days with the glucocorticoid dexamethasone markedly suppressed IL-6 production. Dexamethasone 71-84 interleukin 6 Homo sapiens 105-109 9510155-6 1998 PD98059 inhibited TNF-alpha, IL-3, granulocyte-macrophage (GM)-CSF, IFN-gamma, and to a lesser extent IL-6 and IL-10 production but enhanced IL-4, IL-5, and IL-13 production induced by CD3/PMA or CD3/CD28. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 interleukin 6 Homo sapiens 102-106 9504629-4 1998 Mitogenic stimulation with phorbol 12-myristate 13-acetate (PMA) or PMA plus interleukin-2 (IL-2) resulted in a tremendous increase in TNF-alpha and IL-6 production in cells representing early stage (Binet A) disease. Tetradecanoylphorbol Acetate 27-58 interleukin 6 Homo sapiens 149-153 9504629-4 1998 Mitogenic stimulation with phorbol 12-myristate 13-acetate (PMA) or PMA plus interleukin-2 (IL-2) resulted in a tremendous increase in TNF-alpha and IL-6 production in cells representing early stage (Binet A) disease. Tetradecanoylphorbol Acetate 60-63 interleukin 6 Homo sapiens 149-153 9504629-4 1998 Mitogenic stimulation with phorbol 12-myristate 13-acetate (PMA) or PMA plus interleukin-2 (IL-2) resulted in a tremendous increase in TNF-alpha and IL-6 production in cells representing early stage (Binet A) disease. Tetradecanoylphorbol Acetate 68-71 interleukin 6 Homo sapiens 149-153 9504629-7 1998 The most remarkable difference was recorded in PMA-stimulated (1 ng/ml) IL-6 production. Tetradecanoylphorbol Acetate 47-50 interleukin 6 Homo sapiens 72-76 9497331-4 1998 To elucidate the mechanisms activating the Stat3 gene, we identified an IL-6 response element (IL-6RE) in the Stat3 gene promoter containing both a low affinity STAT3-binding element and a cAMP-responsive element (CRE). Cyclic AMP 189-193 interleukin 6 Homo sapiens 72-76 9506551-2 1998 Here, we report that in patients with MS the combined action of interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNFalpha), interleukin (IL)-2, and IL-6 leads to the activation of most peripheral T cells (mainly CD4 memory) by promoting a persistent intracellular calcium increase via two independent signaling pathways. Calcium 274-281 interleukin 6 Homo sapiens 158-162 9568745-4 1998 Interleukin-6, the mediator of the acute phase response, was increased in the combined patient group (3.2 vs. 1.5, median, pg/ml, P=.0002) and correlated with fibrinogen (r=0.32, P=0.01) and inversely with HDL-cholesterol (r=0.39, P < 0.01), consistent with a persistent inflammatory response. Cholesterol 210-221 interleukin 6 Homo sapiens 0-13 9562370-0 1998 IL-6 antisense oligonucleotides inhibit IgE production in IL-4 and anti-CD40-stimulated human B-lymphocytes. Oligonucleotides 15-31 interleukin 6 Homo sapiens 0-4 9562370-3 1998 To assess the importance of IL-6 in the differentiation process, an antisense oligonucleotide to IL-6 was added to tonsillar B-cells together with CD40 antibodies and IL-4. Oligonucleotides 78-93 interleukin 6 Homo sapiens 97-101 9499112-5 1998 Addition of therapeutic concentrations of dexamethasone (1 microM) or ribavirin (90 microg/ml), an antiviral agent, also significantly inhibited the synthesis of IL-6. Dexamethasone 42-55 interleukin 6 Homo sapiens 162-166 9499112-6 1998 Hence, in clinical settings, pharmacological agents such as the specific antagonists of IL-6-inducing cytokines, as well as dexamethasone and ribavirin, could be used to modulate IL-6 production. Dexamethasone 124-137 interleukin 6 Homo sapiens 179-183 9544449-0 1998 Oxidation of erythrocyte glutathione by monocytes stimulated with interleukin-6. Glutathione 25-36 interleukin 6 Homo sapiens 66-79 9548183-1 1998 Elevated uterine concentrations of interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumour-necrosis factor-alpha (TNF-alpha) are suspected to cause increased prostaglandin release from gestational tissues, but little information is available about the expression pattern of cytokine receptors in these tissues. Prostaglandins 164-177 interleukin 6 Homo sapiens 65-78 9548183-1 1998 Elevated uterine concentrations of interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumour-necrosis factor-alpha (TNF-alpha) are suspected to cause increased prostaglandin release from gestational tissues, but little information is available about the expression pattern of cytokine receptors in these tissues. Prostaglandins 164-177 interleukin 6 Homo sapiens 80-84 9544449-3 1998 This allowed the ability of the cytokine interleukin-6 (IL-6) to stimulate release of ROS from monocytes to be assessed in terms of oxidative damage to other cells, providing an estimation of its importance in vivo. Reactive Oxygen Species 86-89 interleukin 6 Homo sapiens 41-54 9544449-3 1998 This allowed the ability of the cytokine interleukin-6 (IL-6) to stimulate release of ROS from monocytes to be assessed in terms of oxidative damage to other cells, providing an estimation of its importance in vivo. Reactive Oxygen Species 86-89 interleukin 6 Homo sapiens 56-60 9544449-4 1998 It was found that incubation of monocytes with erythrocytes in the presence of IL-6 resulted in oxidation of the erythrocyte glutathione pool, indicating that oxidants are released in sufficient amounts to cause oxidative stress. Glutathione 125-136 interleukin 6 Homo sapiens 79-83 9486420-7 1998 In addition, the inhibitory effect of dexamethasone on both IL-6 and TNF-alpha secretion was significantly reduced following exercise, whereas that on IL-10 and IFN-gamma release was not affected. Dexamethasone 38-51 interleukin 6 Homo sapiens 60-64 9466577-9 1998 Sphingomyelinase activation was determined by quantitation of sphingomyelin and ceramide radioactivity in [14C]serine-prelabeled HSF cells. Serine 111-117 interleukin 6 Homo sapiens 129-132 9473665-7 1998 Although IL-6 was previously found to produce mesolimbic dopamine (DA) changes as marked as those induced by IL-2, systemic IL-6 treatment did not influence responding for rewarding brain stimulation. Dopamine 57-65 interleukin 6 Homo sapiens 9-13 9441573-7 1998 Elevated levels of circulating interleukin-6 have been seen in the steroid withdrawal syndrome and in the severe inflammatory, infectious, and traumatic states potentially associated with the inappropriate secretion of vasopressin. Steroids 67-74 interleukin 6 Homo sapiens 31-44 9537674-4 1998 RESULTS: There was a significant inhibition by dexamethasone (from 1 to 100 nM) on the secretion of monokines (IL-1beta, IL-6, IL-8 and TNF alpha) and lymphokines (IL-2, IL-4, IL-10 and IFN gamma), either after LPS or PHA stimulation (P < 0.01). Dexamethasone 47-60 interleukin 6 Homo sapiens 121-125 9462584-8 1998 Among the hemodynamic variables and the various neurohumoral factors, the plasma norepinephrine (NE) level showed an independent and significant positive relation with the plasma IL-6 level in patients with CHF. Norepinephrine 81-95 interleukin 6 Homo sapiens 179-183 9570533-2 1998 It is reported here that melatonin induces the secretion of IL-1, IL-6, and TNF in fresh and 1-day in vitro cultured monocytes that also express the melatonin receptor (Kd = 270 +/- 60 pM; 42,000-48,000 receptors/cell). Melatonin 25-34 interleukin 6 Homo sapiens 66-70 9473665-7 1998 Although IL-6 was previously found to produce mesolimbic dopamine (DA) changes as marked as those induced by IL-2, systemic IL-6 treatment did not influence responding for rewarding brain stimulation. Dopamine 67-69 interleukin 6 Homo sapiens 9-13 9505142-5 1998 The upregulation of IL-6 production induced by BK was abolished by the anti-inflammatory agent dexamethasone (DEX) and the phospholipase A2 (PLA2) inhibitor 4-bromphenacyl bromide (BPB). Dexamethasone 95-108 interleukin 6 Homo sapiens 20-24 9505142-5 1998 The upregulation of IL-6 production induced by BK was abolished by the anti-inflammatory agent dexamethasone (DEX) and the phospholipase A2 (PLA2) inhibitor 4-bromphenacyl bromide (BPB). Dexamethasone 110-113 interleukin 6 Homo sapiens 20-24 9457465-10 1998 TNF-alpha, IL-1 beta, IL-6, and IL-10 were each synergistic or additive with PGE2 in upregulating the promoter. Dinoprostone 77-81 interleukin 6 Homo sapiens 22-26 9792466-4 1998 Furthermore, we determined whether systemically-acting steroid hormones of gonadal and adrenal origin as well as glucocorticoids affect the local regulation of IL-6 secretion in primary HOC. Steroids 55-62 interleukin 6 Homo sapiens 160-164 9792466-9 1998 Dexa inhibits the constitutive and cytokine stimulated IL-6 expression, whereas there is no in vitro evidence that sex steroids exert a major inhibitory effect on the osteoblastic secretion of IL-6 as demonstrated in a primary human bone cell model. Dexamethasone 0-4 interleukin 6 Homo sapiens 55-59 9792467-0 1998 Effects of 17beta-estradiol and progesterone on interleukin-6 production and proliferation of human umbilical vein endothelial cells. Estradiol 11-27 interleukin 6 Homo sapiens 48-61 9792467-0 1998 Effects of 17beta-estradiol and progesterone on interleukin-6 production and proliferation of human umbilical vein endothelial cells. Progesterone 32-44 interleukin 6 Homo sapiens 48-61 9792467-1 1998 The present investigation was performed to study the effects of steroids on interleukin-6 (IL-6) production and on proliferation of human umbilical vein endothelial cells (HUVEC). Steroids 64-72 interleukin 6 Homo sapiens 76-89 9792467-1 1998 The present investigation was performed to study the effects of steroids on interleukin-6 (IL-6) production and on proliferation of human umbilical vein endothelial cells (HUVEC). Steroids 64-72 interleukin 6 Homo sapiens 91-95 9505191-6 1998 JAK tyrosine kinase is a key molecule that can initiate multiple signal-transduction pathways by inducing the tyrosine-phosphorylation of the cytokine receptor, gp130 in the case of IL-6, on which several signaling molecules are recruited, including STAT, a signal transducer and activator of transcription, and SHP-2, which links to the Ras-MAP kinase pathway. Tyrosine 4-12 interleukin 6 Homo sapiens 182-186 9792467-5 1998 17Beta-estradiol significantly inhibited basal IL-6 secretion at doses of 10(-12)-10(-6) mol/l whereas progesterone had no measurable effects. Estradiol 0-16 interleukin 6 Homo sapiens 47-51 9792467-7 1998 The results of our study suggest that 17beta-estradiol at non-proliferative doses regulates IL-6 secretion of endothelial cells and thereby modulates processes of vascular physiology. Estradiol 38-54 interleukin 6 Homo sapiens 92-96 9704387-5 1998 After 2 h, mRNAs for IL-1 beta and IL-6 were highly upregulated in noncoated compared to heparin-coated circuits. Heparin 89-96 interleukin 6 Homo sapiens 35-39 9452133-8 1998 There was an inverse relationship between TC and IL-6 levels, with r = -0.51 for the entire curve and r = -0.90 for the cholesterol nadir with the IL-6 peak. Cholesterol 120-131 interleukin 6 Homo sapiens 49-53 9452133-8 1998 There was an inverse relationship between TC and IL-6 levels, with r = -0.51 for the entire curve and r = -0.90 for the cholesterol nadir with the IL-6 peak. Cholesterol 120-131 interleukin 6 Homo sapiens 147-151 9850935-0 1998 Potential link between interleukin-6 and arachidonic acid metabolism in Alzheimer"s disease. Arachidonic Acid 41-57 interleukin 6 Homo sapiens 23-36 9850935-1 1998 Prostaglandins (PGs) and cytokines, such as interleukin-1 (IL-1) and interleukin-6 (IL-6), have been implicated in the etiopathology of various inflammatory and degenerative disorders, including Alzheimer"s disease (AD). Prostaglandins 0-14 interleukin 6 Homo sapiens 69-82 9850935-1 1998 Prostaglandins (PGs) and cytokines, such as interleukin-1 (IL-1) and interleukin-6 (IL-6), have been implicated in the etiopathology of various inflammatory and degenerative disorders, including Alzheimer"s disease (AD). Prostaglandins 0-14 interleukin 6 Homo sapiens 84-88 9850935-1 1998 Prostaglandins (PGs) and cytokines, such as interleukin-1 (IL-1) and interleukin-6 (IL-6), have been implicated in the etiopathology of various inflammatory and degenerative disorders, including Alzheimer"s disease (AD). Prostaglandins 16-19 interleukin 6 Homo sapiens 84-88 9850935-6 1998 PGE1 and PGE2, but not PGD2 and PGF2 alpha, led to a rapid and transient induction of astrocytic IL-6 mRNA, followed by IL-6 protein synthesis. Dinoprostone 9-13 interleukin 6 Homo sapiens 97-101 9850935-6 1998 PGE1 and PGE2, but not PGD2 and PGF2 alpha, led to a rapid and transient induction of astrocytic IL-6 mRNA, followed by IL-6 protein synthesis. Dinoprostone 9-13 interleukin 6 Homo sapiens 120-124 9850935-7 1998 Furthermore, PGE2 potentiated IL-1 beta-induced IL-6 mRNA synthesis. Dinoprostone 13-17 interleukin 6 Homo sapiens 48-52 9802059-10 1998 In the present experiments DEX only slightly decreased the production and secretion of IL-6 by the cells. Dexamethasone 27-30 interleukin 6 Homo sapiens 87-91 9802059-11 1998 The present findings suggest that the slight cytotoxic activity and the drug resistance effects of DEX on PC-3 cells are mediated by induction of lipocortin 1 and inhibition of arachidonic acid metabolism, with no relationship to downregulation of IL-6 levels. Dexamethasone 99-102 interleukin 6 Homo sapiens 248-252 9654608-13 1998 In additional to activation of neutrophils in preeclampsia, there may be involvement of the interleukin-6 and endothelin-1 in "priming" neutrophils for subsequent superoxide production. Superoxides 163-173 interleukin 6 Homo sapiens 92-105 9558728-11 1998 In addition to the tyrosine phosphorylation we have observed that IL-6 also induces a serine phosphorylation of STAT3. Tyrosine 19-27 interleukin 6 Homo sapiens 66-70 9558728-11 1998 In addition to the tyrosine phosphorylation we have observed that IL-6 also induces a serine phosphorylation of STAT3. Serine 86-92 interleukin 6 Homo sapiens 66-70 9496240-0 1998 Effects of cortisol on the expression of interleukin-6 and interleukin-1 beta in human osteoblast-like cells. Hydrocortisone 11-19 interleukin 6 Homo sapiens 41-54 9552008-4 1998 Sera from patients administered mAb-KLH+BCG followed by AAAP contained three distinct classes of IL-6 eluting at 30, 200, and 450 kDa, each with its characteristic ELISA reactivity and bioactivity: the 30- and 450-kDa complexes were bioactive in the B9 and Hep3B assays, but the 200-kDa complex was not. CHEMBL2385481 36-39 interleukin 6 Homo sapiens 97-101 9552008-5 1998 The 30- and 450-kDa IL-6 complexes were preferentially reactive in the 7IL6/5IL6 ELISA, the 200-kDa IL-6 complexes were preferentially reactive in the 4IL6/5IL6 ELISA, while the three commercial ELISAs (R&D, Endogen, and Genzyme) detected essentially only the 30-kDa IL-6. Adenosine Monophosphate 205-208 interleukin 6 Homo sapiens 100-104 9552008-5 1998 The 30- and 450-kDa IL-6 complexes were preferentially reactive in the 7IL6/5IL6 ELISA, the 200-kDa IL-6 complexes were preferentially reactive in the 4IL6/5IL6 ELISA, while the three commercial ELISAs (R&D, Endogen, and Genzyme) detected essentially only the 30-kDa IL-6. Adenosine Monophosphate 205-208 interleukin 6 Homo sapiens 100-104 9501294-11 1998 Amniotic fluid NOx was significantly correlated with IL-6 (r = .4, P = .02). nicotine 1-N-oxide 15-18 interleukin 6 Homo sapiens 53-57 9501294-12 1998 Both amniotic fluid NOx and IL-6 were also positively correlated with amniotic fluid leukocyte counts, leukocyte esterase activity and Gram stains, and negatively correlated with glucose levels. Glucose 179-186 interleukin 6 Homo sapiens 28-32 9509508-1 1998 The aim of this study was to investigate the serum levels of interleukin-2 (IL-2) and interleukin-6 (IL-6) in children with iron deficiency anemia before and after iron supplementation. Iron 124-128 interleukin 6 Homo sapiens 86-99 9509508-1 1998 The aim of this study was to investigate the serum levels of interleukin-2 (IL-2) and interleukin-6 (IL-6) in children with iron deficiency anemia before and after iron supplementation. Iron 124-128 interleukin 6 Homo sapiens 101-105 9506876-2 1998 Spontaneous and IL-1 + TNF-alpha stimulated IL-6 release was measured in supernatants of cultures of human osteoblastic osteosarcoma cells MG-63, pretreated for 4 hours with different doses of etidronate, clodronate or alendronate using a specific bioassay. Etidronic Acid 193-203 interleukin 6 Homo sapiens 44-48 9506876-3 1998 Etidronate [from 10(-4) to 10(-8) M] or alendronate [from 10(-6) to 10(-11) M] inhibited in a dose-dependent manner the cytokine-induced IL-6 secretion [60+/-9.5% at 10(-5) M and 65+/-12% at 10(-7) M, respectively; p < 0.01]. Etidronic Acid 0-10 interleukin 6 Homo sapiens 137-141 9558728-13 1998 We propose that the STAT3 serine phosphorylation is required for transactivation of IL-6 target genes which is also inhibited by H7. Serine 26-32 interleukin 6 Homo sapiens 84-88 9430873-7 1997 Thus, urinary IL-6/EGF ratio was markedly increased in the former group (> 20-fold at day 1), where it paralleled the modifications of plasma creatinine over time (r:0.603, P < 0.0001), and was only slightly increased in the latter group (< 3-fold). Creatinine 145-155 interleukin 6 Homo sapiens 14-18 9413347-5 1997 Cyclosporine reduced the serum levels of ferritin, interferon-tau, interleukin-6, and soluble interleukin-2 receptor. Cyclosporine 0-12 interleukin 6 Homo sapiens 67-80 9412570-0 1997 Beryllium-stimulated release of tumor necrosis factor-alpha, interleukin-6, and their soluble receptors in chronic beryllium disease. Beryllium 0-9 interleukin 6 Homo sapiens 61-74 9412570-2 1997 We hypothesized that beryllium salts would stimulate bronchoalveolar lavage (BAL) cell release of tumor necrosis factor-alpha (TNF-alpha) and lnterleukin-6 (IL-6), and their soluble receptors, soluble TNF receptor I (sTNF RI), sTNF RII, and sIL-6R and that chronic exposure to antigen would increase production of soluble receptors in the serum and BAL fluid (BALF) of beryllium-sensitized and CBD patients. Beryllium 21-30 interleukin 6 Homo sapiens 157-161 9412570-2 1997 We hypothesized that beryllium salts would stimulate bronchoalveolar lavage (BAL) cell release of tumor necrosis factor-alpha (TNF-alpha) and lnterleukin-6 (IL-6), and their soluble receptors, soluble TNF receptor I (sTNF RI), sTNF RII, and sIL-6R and that chronic exposure to antigen would increase production of soluble receptors in the serum and BAL fluid (BALF) of beryllium-sensitized and CBD patients. Beryllium 369-378 interleukin 6 Homo sapiens 157-161 9398733-0 1997 Dose-dependent effects of recombinant human interleukin-6 on glucose regulation. Glucose 61-68 interleukin 6 Homo sapiens 44-57 9398733-2 1997 To examine the effects of interleukin 6 (IL-6), the main circulating cytokine, on glucose metabolism in man, we performed dose-response studies of recombinant human IL-6 in normal volunteers. Glucose 82-89 interleukin 6 Homo sapiens 41-45 9398733-8 1997 By 60 min after the 3 higher IL-6 doses, however, the decline in fasting blood glucose was arrested, and glucose levels increased in a dose-dependent fashion. Glucose 79-86 interleukin 6 Homo sapiens 29-33 9398733-8 1997 By 60 min after the 3 higher IL-6 doses, however, the decline in fasting blood glucose was arrested, and glucose levels increased in a dose-dependent fashion. Glucose 105-112 interleukin 6 Homo sapiens 29-33 9398733-11 1997 In conclusion, sc IL-6 administration induced dose-dependent increases in fasting blood glucose, probably by stimulating glucagon release and other counteregulatory hormones and/or by inducing peripheral resistance to insulin action. Glucose 88-95 interleukin 6 Homo sapiens 18-22 9469525-13 1997 morphine reduced cortisol and IL-6 levels in the early hours after surgery. Morphine 0-8 interleukin 6 Homo sapiens 30-34 9408252-7 1997 Production of both IL-6 and IL-8 was stimulated in a concentration-dependent fashion by interleukin-1beta (0.1-10 ng/ml), tumor necrosis factor-alpha (1-100 ng/ml), and bacterial lipopolysaccharide (0.1-10 microg/ml), and also by 100 nM phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 237-268 interleukin 6 Homo sapiens 19-23 9408252-9 1997 Dexamethasone (10 nM) inhibited IL-6/-8 production by approximately 50% throughout the culture period. Dexamethasone 0-13 interleukin 6 Homo sapiens 32-39 9403756-8 1997 Tumor necrosis factor-alpha, interleukin-1, and interleukin-6 were stimulated by lipopolysaccharide (endotoxin) and all of these cytokines were significantly (p < .05) inhibited by perflubron. perflubron 184-194 interleukin 6 Homo sapiens 48-61 9406996-4 1997 In the IL-6-dependent cell line B-9, IL-6 induced a rapid, transient, and concentration-dependent tyrosine phosphorylation of several cytosolic proteins as detected by antiphosphotyrosine immunoblots. Tyrosine 98-106 interleukin 6 Homo sapiens 7-11 9406996-4 1997 In the IL-6-dependent cell line B-9, IL-6 induced a rapid, transient, and concentration-dependent tyrosine phosphorylation of several cytosolic proteins as detected by antiphosphotyrosine immunoblots. Tyrosine 98-106 interleukin 6 Homo sapiens 37-41 9406996-6 1997 Similar effects of IL-6 on tyrosine phosphorylation were observed in the human multiple myeloma cell line LP-1. Tyrosine 27-35 interleukin 6 Homo sapiens 19-23 9406996-8 1997 IL-6 induced the activation and tyrosine phosphorylation of p59Fyn, p56/59Hck, and p56Lyn. Tyrosine 32-40 interleukin 6 Homo sapiens 0-4 9496264-5 1997 Dexamethasone decreased the IL-1-stimulated IL-6 release in all cases. Dexamethasone 0-13 interleukin 6 Homo sapiens 44-48 9360537-8 1997 However, in combination with IL-6, dexamethasone had a significant additive effect on IL-6 inhibition of CBG secretion and mRNAs in HepG2 cells. Dexamethasone 35-48 interleukin 6 Homo sapiens 86-90 9449430-5 1997 The glucocorticoid dexamethasone inhibited the IL-1beta-activated release of IL-6 from the postmortem astrocyte cultures A157 and A295 and from the astroglioma cell lines. Dexamethasone 19-32 interleukin 6 Homo sapiens 77-81 9449430-8 1997 Addition of exogenous PGE2 prevented the inhibitory effect of indomethacin and BF389 on the IL-1beta-activated IL-6 release from A157 astrocytes and largely potentiated the IL-1-induced release of IL-6 from all astrocytes/astroglioma cells tested. Dinoprostone 22-26 interleukin 6 Homo sapiens 111-115 9449430-8 1997 Addition of exogenous PGE2 prevented the inhibitory effect of indomethacin and BF389 on the IL-1beta-activated IL-6 release from A157 astrocytes and largely potentiated the IL-1-induced release of IL-6 from all astrocytes/astroglioma cells tested. Dinoprostone 22-26 interleukin 6 Homo sapiens 197-201 9449430-9 1997 Dexamethasone also inhibited the PGE2 release from the astrocytes and astroglioma cells, however the inhibitory effect of dexamethasone on the IL-1beta-activated IL-6 release could not be prevented by the addition of PGE2. Dexamethasone 122-135 interleukin 6 Homo sapiens 162-166 9373220-0 1997 Rapamycin antagonizes interleukin-6 mediated growth arrest and differentiation of myeloblastic M1 cells. Sirolimus 0-9 interleukin 6 Homo sapiens 22-35 9373220-4 1997 In spite of this intrinsic antiproliferative effect, rapamycin was found to abrogate IL-6 induced growth arrest. Sirolimus 53-62 interleukin 6 Homo sapiens 85-89 9373220-6 1997 Excess levels of the FK-506 analogue ascomycin reversed the antagonistic effect of rapamycin on IL-6 mediated growth suppression, suggesting that this biological action of rapamycin is mediated by a rapamycin/immunophilin complex. Sirolimus 83-92 interleukin 6 Homo sapiens 96-100 9373220-6 1997 Excess levels of the FK-506 analogue ascomycin reversed the antagonistic effect of rapamycin on IL-6 mediated growth suppression, suggesting that this biological action of rapamycin is mediated by a rapamycin/immunophilin complex. Sirolimus 172-181 interleukin 6 Homo sapiens 96-100 9393919-3 1997 Particles of titanium-6-aluminium-4-vanadium (TiAIV) stimulated MNP to release interleukin (IL)-1beta, tumour necrosis factor (TNF)alpha, IL-6 and prostaglandin E2 (PGE2). tiaiv 46-51 interleukin 6 Homo sapiens 138-142 9359399-6 1997 In this study we have examined the HSF DNA-binding activity in HeLa cells maintained in the sorbitol/water binary solution over a wide concentration range (0.1-0.9 M) and in Dulbecco"s medium supplemented with sorbitol or NaCl. Water 101-106 interleukin 6 Homo sapiens 35-38 9402932-0 1997 Ethanol activates the interleukin-6 promoter in a human bone marrow stromal cell line. Ethanol 0-7 interleukin 6 Homo sapiens 22-35 9402932-3 1997 We hypothesized that ethanol promotes osteoporosis, in part, by increasing IL-6 production in the bone microenvironment. Ethanol 21-28 interleukin 6 Homo sapiens 75-79 9402932-4 1997 Accordingly, we evaluated ethanol"s effect on IL-6 production in the Saka human bone marrow stromal cell line and in the HOBIT human osteoblast-like cell line. Ethanol 26-33 interleukin 6 Homo sapiens 46-50 9402932-5 1997 We found that ethanol increased IL-6 protein levels in the culture supernatants from Saka, but not HOBIT, cells. Ethanol 14-21 interleukin 6 Homo sapiens 32-36 9402932-6 1997 In addition, we observed that ethanol increased steady-state IL-6 mRNA levels and activated an IL-6 promoter-driven reporter vector in Saka cells. Ethanol 30-37 interleukin 6 Homo sapiens 61-65 9402932-6 1997 In addition, we observed that ethanol increased steady-state IL-6 mRNA levels and activated an IL-6 promoter-driven reporter vector in Saka cells. Ethanol 30-37 interleukin 6 Homo sapiens 95-99 9402932-7 1997 We conclude that ethanol stimulates IL-6 expression in the Saka bone marrow stromal cell line by enhancing transcriptional activity of the IL-6 gene. Ethanol 17-24 interleukin 6 Homo sapiens 36-40 9402932-7 1997 We conclude that ethanol stimulates IL-6 expression in the Saka bone marrow stromal cell line by enhancing transcriptional activity of the IL-6 gene. Ethanol 17-24 interleukin 6 Homo sapiens 139-143 9402932-8 1997 Our findings support the contention that ethanol may contribute to the pathogenesis of osteoporosis, in part, by increasing IL-6 expression in the bone microenvironment. Ethanol 41-48 interleukin 6 Homo sapiens 124-128 9373190-0 1997 Modulation of the DNA binding activity of transcription factors CREP, NFkappaB and HSF by H2O2 and TNF alpha. Hydrogen Peroxide 90-94 interleukin 6 Homo sapiens 83-86 9373190-2 1997 Human endothelial cells exposed to H2O2 showed reduced CREP DNA binding activity, enhanced HSF activation, and no induction of NFkappaB binding activity. Hydrogen Peroxide 35-39 interleukin 6 Homo sapiens 91-94 9373190-6 1997 Thus free sulfhydryls were important in DNA binding activity of CREP, NFkappaB and HSF, and the lack of induction of NFkappaB by H2O2 in intact cells was likely caused by oxidation on a thiol, and not by a deficiency in the activation pathway. Sulfhydryl Compounds 10-21 interleukin 6 Homo sapiens 83-86 9343414-9 1997 Interestingly, the cytokine interleukin-6 also stimulates STAT3 serine phosphorylation, but in contrast to growth factors, this occurs by an ERK-independent process. Serine 64-70 interleukin 6 Homo sapiens 28-41 9351770-7 1997 Elevated interleukin-6 levels were associated independently with neonatal morbidity in multiple logistic regression modeling that included gestational age, birth weight, and antenatal steroid exposure. Steroids 184-191 interleukin 6 Homo sapiens 9-22 9359399-6 1997 In this study we have examined the HSF DNA-binding activity in HeLa cells maintained in the sorbitol/water binary solution over a wide concentration range (0.1-0.9 M) and in Dulbecco"s medium supplemented with sorbitol or NaCl. Sodium Chloride 222-226 interleukin 6 Homo sapiens 35-38 9378980-3 1997 IL-6 induction was dependent on the intracellular redox-oxidative state, since intracellular hydroxyl scavengers and N-acetylcysteine, a precursor of glutathione, abrogated IL-6 secretion by asbestos or H2O2. Acetylcysteine 117-133 interleukin 6 Homo sapiens 0-4 9378980-3 1997 IL-6 induction was dependent on the intracellular redox-oxidative state, since intracellular hydroxyl scavengers and N-acetylcysteine, a precursor of glutathione, abrogated IL-6 secretion by asbestos or H2O2. Acetylcysteine 117-133 interleukin 6 Homo sapiens 173-177 9378980-3 1997 IL-6 induction was dependent on the intracellular redox-oxidative state, since intracellular hydroxyl scavengers and N-acetylcysteine, a precursor of glutathione, abrogated IL-6 secretion by asbestos or H2O2. Glutathione 150-161 interleukin 6 Homo sapiens 0-4 9378980-3 1997 IL-6 induction was dependent on the intracellular redox-oxidative state, since intracellular hydroxyl scavengers and N-acetylcysteine, a precursor of glutathione, abrogated IL-6 secretion by asbestos or H2O2. Glutathione 150-161 interleukin 6 Homo sapiens 173-177 9325293-7 1997 Among these three cytokines, only IL-6 synthesis was stimulated by production of endogenous PGE2. Dinoprostone 92-96 interleukin 6 Homo sapiens 34-38 9378980-3 1997 IL-6 induction was dependent on the intracellular redox-oxidative state, since intracellular hydroxyl scavengers and N-acetylcysteine, a precursor of glutathione, abrogated IL-6 secretion by asbestos or H2O2. Hydrogen Peroxide 203-207 interleukin 6 Homo sapiens 0-4 9378980-3 1997 IL-6 induction was dependent on the intracellular redox-oxidative state, since intracellular hydroxyl scavengers and N-acetylcysteine, a precursor of glutathione, abrogated IL-6 secretion by asbestos or H2O2. Hydrogen Peroxide 203-207 interleukin 6 Homo sapiens 173-177 9378980-6 1997 Stimulation of DNA binding activity to the NF-kappa B and NF-IL-6 binding sites of the IL-6 promoter by asbestos or H2O2 were inhibited by tetramethylthiourea, a hydroxyl radical scavenger. Hydrogen Peroxide 116-120 interleukin 6 Homo sapiens 61-65 9368513-4 1997 The effects of dexamethasone and 17 beta-oestradiol on IL-1-, TNF-, TSH-, forskolin- and phorbol 12-myristate 13-acetate (PMA)-stimulated IL-6 release in serum-free conditions were studied in human thyrocytes derived from patients with Graves" disease and toxic multinodular goitres, and in the immortalised human thyrocyte cell line, HTori3. Tetradecanoylphorbol Acetate 122-125 interleukin 6 Homo sapiens 138-142 9352014-6 1997 Basal and cytokine-stimulated IL-6 and IL-8 production was inhibited by dexamethasone at concentrations equal to or greater than 1 nM. Dexamethasone 72-85 interleukin 6 Homo sapiens 30-34 9383257-3 1997 Histamine is a potent activator of endothelial cells (EC): it induces the expression of P-selectin on the surface of endothelium and the secretion of IL-6 and IL-8. Histamine 0-9 interleukin 6 Homo sapiens 150-154 9383257-7 1997 L and DCL inhibited significantly IL-6 and IL-8 secretion induced by histamine with a more powerful efficiency of the active metabolite. Histamine 69-78 interleukin 6 Homo sapiens 34-38 9383257-8 1997 For the dose of 10(-4) M histamine, a 50% inhibition of IL-6 secretion was obtained for a dose of DCL equal to 2.6 x 10(-12) M whereas the same magnitude of effects were only reached for a higher concentration of L (0.3 x 10[-6] M). Histamine 25-34 interleukin 6 Homo sapiens 56-60 9322921-4 1997 Furthermore, interleukin-6-induced tyrosine phosphorylation can occur independent of serine phosphorylation, demonstrating that these two phosphorylation pathways are mechanistically unrelated. Tyrosine 35-43 interleukin 6 Homo sapiens 13-26 9368513-2 1997 The secretion of IL-6 can be stimulated by interleukin-1 (IL-1), tumour necrosis factor-alpha (TNF), serum, TSH and agents which increase intracellular cyclic AMP levels. Cyclic AMP 152-162 interleukin 6 Homo sapiens 17-21 9368513-4 1997 The effects of dexamethasone and 17 beta-oestradiol on IL-1-, TNF-, TSH-, forskolin- and phorbol 12-myristate 13-acetate (PMA)-stimulated IL-6 release in serum-free conditions were studied in human thyrocytes derived from patients with Graves" disease and toxic multinodular goitres, and in the immortalised human thyrocyte cell line, HTori3. Dexamethasone 15-28 interleukin 6 Homo sapiens 138-142 9368513-4 1997 The effects of dexamethasone and 17 beta-oestradiol on IL-1-, TNF-, TSH-, forskolin- and phorbol 12-myristate 13-acetate (PMA)-stimulated IL-6 release in serum-free conditions were studied in human thyrocytes derived from patients with Graves" disease and toxic multinodular goitres, and in the immortalised human thyrocyte cell line, HTori3. Estradiol 33-51 interleukin 6 Homo sapiens 138-142 9368513-4 1997 The effects of dexamethasone and 17 beta-oestradiol on IL-1-, TNF-, TSH-, forskolin- and phorbol 12-myristate 13-acetate (PMA)-stimulated IL-6 release in serum-free conditions were studied in human thyrocytes derived from patients with Graves" disease and toxic multinodular goitres, and in the immortalised human thyrocyte cell line, HTori3. Tetradecanoylphorbol Acetate 89-120 interleukin 6 Homo sapiens 138-142 9347083-9 1997 The results on the production of IL-6 and IFN-gamma in AWLD and cirrhotic patients showed that only cirrhotic patients with a prolonged EtOH withdrawal period display abnormal production. Ethanol 136-140 interleukin 6 Homo sapiens 33-37 9390345-7 1997 Reverse transcription-polymerase chain reaction (RT-PCR) detected IL-6 mRNA in the lesional skin in all cases, levels of which were decreased after the effective intralesional steroid therapy, but which were unchanged after ineffective topical photochemotherapy (PUVA). Steroids 176-183 interleukin 6 Homo sapiens 66-70 9390345-8 1997 Peripheral blood mononuclear cells from the patients produced significantly large quantities of IL-6 which were reduced by addition of steroid in vitro. Steroids 135-142 interleukin 6 Homo sapiens 96-100 9390345-9 1997 These results suggest that the generation of IL-6 plays the key role in cutaneous plasmacytosis and that intralesional steroid therapy is effective in reducing the production of IL-6 in this disorder. Steroids 119-126 interleukin 6 Homo sapiens 178-182 9368513-5 1997 Dexamethasone inhibited IL-6 production under stimulated conditions. Dexamethasone 0-13 interleukin 6 Homo sapiens 24-28 9368513-8 1997 In Graves" and multinodular goitre thyrocytes, inhibition of IL-1 (100 U/ml)-stimulated IL-6 release by dexamethasone (100 nmol/l) was 62.51% +/- 10.43 (S.E.M. Dexamethasone 104-117 interleukin 6 Homo sapiens 88-92 9378738-10 1997 In contrast, the fluoroquinolone antibiotic ciprofloxacin, which is also a phosphodiesterase inhibitor, caused a dose-dependent inhibition of the synthesis of both tumor necrosis factor-alpha and interleukin-6 by titanium-stimulated monocytes, suggesting that ciprofloxacin suppresses the synthesis of interleukin-6 through a mechanism that is independent of cAMP. Titanium 213-221 interleukin 6 Homo sapiens 196-209 9391781-12 1997 Looking specifically at two homogeneous subgroups including either naturally/5-aminosalicylic acid (5-ASA) quiescent or corticoid quiescent patients, a very good predictive value for interleukin-6 serum concentration was also found. Mesalamine 77-98 interleukin 6 Homo sapiens 183-196 9391781-12 1997 Looking specifically at two homogeneous subgroups including either naturally/5-aminosalicylic acid (5-ASA) quiescent or corticoid quiescent patients, a very good predictive value for interleukin-6 serum concentration was also found. 5-Aminosalicylic acid 100-105 interleukin 6 Homo sapiens 183-196 9450626-4 1997 To identify cytokines which could increase DC in tissues we tested the ability of GM-CSF, TNF-alpha and IL-6 to partially prevent steroid depletion of Langerhans cells (LC) from the epidermis. Steroids 130-137 interleukin 6 Homo sapiens 104-108 9378738-4 1997 Dibutyryl cAMP enhanced the synthesis of interleukin-6 by titanium-stimulated monocytes and resulted in a marked increase (maximum, seventyfold) in the synthesis of interleukin-6 even in the absence of titanium particles. Titanium 58-66 interleukin 6 Homo sapiens 41-54 9378738-10 1997 In contrast, the fluoroquinolone antibiotic ciprofloxacin, which is also a phosphodiesterase inhibitor, caused a dose-dependent inhibition of the synthesis of both tumor necrosis factor-alpha and interleukin-6 by titanium-stimulated monocytes, suggesting that ciprofloxacin suppresses the synthesis of interleukin-6 through a mechanism that is independent of cAMP. Titanium 213-221 interleukin 6 Homo sapiens 302-315 9401927-5 1997 This result suggests that endogenous prostaglandin E2 (PGE2) partially inhibits IL-1 or TNF-alpha-induced IL-6 production and that the enhancement of IL-6 production by IL-1 or TNF-alpha may not be caused through endogenous PGE2-induced cAMP-dependent pathway. Dinoprostone 37-53 interleukin 6 Homo sapiens 106-110 9326397-7 1997 Therefore, following injury, accumulation of interleukin-6 can lead to production by alkaline phosphatase of adenosine and subsequent protection from ischemic injury. Adenosine 109-118 interleukin 6 Homo sapiens 45-58 9401927-5 1997 This result suggests that endogenous prostaglandin E2 (PGE2) partially inhibits IL-1 or TNF-alpha-induced IL-6 production and that the enhancement of IL-6 production by IL-1 or TNF-alpha may not be caused through endogenous PGE2-induced cAMP-dependent pathway. Dinoprostone 55-59 interleukin 6 Homo sapiens 106-110 9401927-6 1997 Dexamethasone (DEX), a glucocorticoid which is a inhibitor of nuclear factor kappa B (NF-kappa B activation, markedly inhibited IL-1 (alpha or beta) or TNF-alpha-induced IL-6 production; so this production may be partially mediated through NF-kappa B. Dexamethasone 0-13 interleukin 6 Homo sapiens 170-174 9401927-6 1997 Dexamethasone (DEX), a glucocorticoid which is a inhibitor of nuclear factor kappa B (NF-kappa B activation, markedly inhibited IL-1 (alpha or beta) or TNF-alpha-induced IL-6 production; so this production may be partially mediated through NF-kappa B. Dexamethasone 15-18 interleukin 6 Homo sapiens 170-174 9324056-11 1997 These data suggest that IL-1beta, IL-6 and TNF-alpha display more than additive effects on Sertoli cell transferrin and cGMP secretion and that the combination of these cytokines may explain the major part of the effects observed with crude PBMC-CM. Cyclic GMP 120-124 interleukin 6 Homo sapiens 34-38 9401927-10 1997 Accordingly, in inflamed periodontal tissues, gingival fibroblasts and periodontal ligament fibroblasts stimulated with pro-inflammatory cytokines such as IL-1 or TNF-alpha, may produce IL-6, and this production can be differentially modulated by endogenous PGE2, IL-6sR, T cell-derived cytokines such as IFN-gamma or IL-4, and glucocorticoids. Dinoprostone 258-262 interleukin 6 Homo sapiens 186-190 9392005-3 1997 In addition, we have observed that ligation of CD23 on keratinocytes induced type II nitric oxide synthase (iNOS), leading to the release of nitric oxide (NO) and proinflammatory cytokines (TNF-alpha, IL-6). Nitric Oxide 85-97 interleukin 6 Homo sapiens 201-205 9309306-8 1997 Consequently, these results suggest that physiologically relevant concentrations of ethanol may affect production of inflammatory cytokines, such as tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 by disrupting NF-kappa B signaling in monocytes. Ethanol 84-91 interleukin 6 Homo sapiens 202-215 9315521-8 1997 IL-6 production was decreased by amiodarone in all concentrations but was increased significantly by disopyramide. Amiodarone 33-43 interleukin 6 Homo sapiens 0-4 9315521-8 1997 IL-6 production was decreased by amiodarone in all concentrations but was increased significantly by disopyramide. Disopyramide 101-113 interleukin 6 Homo sapiens 0-4 9315538-5 1997 Ouabain induced the production of interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha in PBMC and induced mRNA of these cytokines, an induction apparently at the transcriptional level. Ouabain 0-7 interleukin 6 Homo sapiens 58-62 9311399-8 1997 In the lavage fluid, concentration of IL-6 was higher in the oxygen-exposed nostril (40.5 [11-128] pg/ml) than in the non-exposed one (7 [0-34] pg/ml; P < 0.05). Oxygen 61-67 interleukin 6 Homo sapiens 38-42 9324026-6 1997 Interleukin-6 (IL-6) partially restored the testosterone-induced decrease in antibody levels in PBMC. Testosterone 44-56 interleukin 6 Homo sapiens 0-13 9292571-9 1997 Significantly higher IL-6 and IL-1beta release was found in the bicarbonate-buffered solutions, both under basal conditions and after LPS stimulation, compared with the lactate-buffered solutions (LPS stimulation: 1% amino acids/34 mmol/L bicarbonate, IL-1beta: 1,166 +/- 192 pg/mL; 1.5% glucose/34 mmol/L bicarbonate, IL-1beta: 752 +/- 107 pg/mL; 1.5% glucose/35 mmol/L lactate/pH 5.5, IL-1beta: 174 +/- 51 pg/mL). Bicarbonates 64-75 interleukin 6 Homo sapiens 21-25 9324026-6 1997 Interleukin-6 (IL-6) partially restored the testosterone-induced decrease in antibody levels in PBMC. Testosterone 44-56 interleukin 6 Homo sapiens 15-19 9324026-7 1997 Testosterone reduced IL-6 production in monocytes. Testosterone 0-12 interleukin 6 Homo sapiens 21-25 9324026-8 1997 CONCLUSION: These results suggest that testosterone may directly suppress anti-DNA antibody production in PBMC from SLE patients by inhibiting B cell hyperactivity and, indirectly, by down-regulating IL-6 production in monocytes. Testosterone 39-51 interleukin 6 Homo sapiens 200-204 9376994-0 1997 The sequential analysis of T lymphocyte subsets and interleukin-6 in polymyalgia rheumatica patients as predictors of disease remission and steroid withdrawal. Steroids 140-147 interleukin 6 Homo sapiens 52-65 9391290-9 1997 IL-6 was associated with raised fibrinogen, sialic acid, and triglycerides. Triglycerides 61-74 interleukin 6 Homo sapiens 0-4 10072866-7 1997 RESULTS: Four transfectants, PGTAS1, PGTAS6, PGTAS8, PGTAS9, could express IL-6 antisense mRNA and secret decreased bioactive IL-6. pgtas9 53-59 interleukin 6 Homo sapiens 75-79 9266970-7 1997 Finally, interleukin-6 (IL-6) inhibits Dex-induced apoptosis, downregulation of MAP and p70S6K growth kinases and PARP cleavage; in contrast, IL-6 does not inhibit IR-induced apoptosis, activation of SAPK/JNK, and PARP cleavage. Dexamethasone 39-42 interleukin 6 Homo sapiens 9-22 9266970-7 1997 Finally, interleukin-6 (IL-6) inhibits Dex-induced apoptosis, downregulation of MAP and p70S6K growth kinases and PARP cleavage; in contrast, IL-6 does not inhibit IR-induced apoptosis, activation of SAPK/JNK, and PARP cleavage. Dexamethasone 39-42 interleukin 6 Homo sapiens 24-28 9265928-8 1997 Serum interleukin-6 was significantly higher in parturients who had epidural analgesia, and was significantly lower in those receiving intravaginal prostaglandins compared to those without prostaglandins. Prostaglandins 148-162 interleukin 6 Homo sapiens 6-19 9265928-8 1997 Serum interleukin-6 was significantly higher in parturients who had epidural analgesia, and was significantly lower in those receiving intravaginal prostaglandins compared to those without prostaglandins. Prostaglandins 189-203 interleukin 6 Homo sapiens 6-19 9265928-11 1997 Regional anaesthesia, duration of labour and exogenous prostaglandin administration can modulate the peripartum interleukin-6 response and subsequently the physiological effects of this cytokine. Prostaglandins 55-68 interleukin 6 Homo sapiens 112-125 9426913-0 1997 In the early stage of major burns, is there a correlation between survival, interleukin-6 levels and oxygen delivery and consumption? Oxygen 101-107 interleukin 6 Homo sapiens 76-89 9267943-12 1997 Rectal temperature and creatinine concentrations correlated significantly with sTNFR 60, sTNFR 80, sIL-6R, and IL-6 concentrations. Creatinine 23-33 interleukin 6 Homo sapiens 100-104 9273875-0 1997 Metal fume fever: characterization of clinical and plasma IL-6 responses in controlled human exposures to zinc oxide fume at and below the threshold limit value. Metals 0-5 interleukin 6 Homo sapiens 58-62 9269644-15 1997 Il-6 release: Amino/Bic, 33.0 +/- 6.6%; Glu/Bic, 65.5 +/- 10.3%; Glu/Lac, 1.5 +/- 0.7% referred to RPMI). Glutamic Acid 40-43 interleukin 6 Homo sapiens 0-4 9269644-15 1997 Il-6 release: Amino/Bic, 33.0 +/- 6.6%; Glu/Bic, 65.5 +/- 10.3%; Glu/Lac, 1.5 +/- 0.7% referred to RPMI). Glutamic Acid 65-68 interleukin 6 Homo sapiens 0-4 9278309-8 1997 Moreover, MAPK antisense, but not sense, oligonucleotide inhibited IL-6-induced proliferation of these cells. Oligonucleotides 41-56 interleukin 6 Homo sapiens 67-71 9282937-0 1997 Stimulation of interleukin-6 secretion and gene transcription in primary astrocytes by adenosine. Adenosine 87-96 interleukin 6 Homo sapiens 15-28 9282937-3 1997 Adenosine stimulated IL-6 secretion in primary astrocytes four- to 10-fold. Adenosine 0-9 interleukin 6 Homo sapiens 21-25 9282937-10 1997 Thus, an increase of extracellular adenosine during focal cerebral ischemia may stimulate IL-6 expression via A2b receptors. Adenosine 35-44 interleukin 6 Homo sapiens 90-94 9263986-10 1997 Phospho-L-serine as an antagonist of the phosphatidylserine (PS) mediated recognition pathway for apoptotic cell disposal was able to reduce binding and IL-6 production by HMC but not phagocytosis. Phosphatidylserines 41-59 interleukin 6 Homo sapiens 153-157 9263986-10 1997 Phospho-L-serine as an antagonist of the phosphatidylserine (PS) mediated recognition pathway for apoptotic cell disposal was able to reduce binding and IL-6 production by HMC but not phagocytosis. Phosphatidylserines 61-63 interleukin 6 Homo sapiens 153-157 9263986-15 1997 In conclusion, apoptotic monocytic cells provoked an enhanced mesangial IL-6 synthesis by a PS-dependent recognition mechanism. Phosphatidylserines 92-94 interleukin 6 Homo sapiens 72-76 10072866-7 1997 RESULTS: Four transfectants, PGTAS1, PGTAS6, PGTAS8, PGTAS9, could express IL-6 antisense mRNA and secret decreased bioactive IL-6. pgtas9 53-59 interleukin 6 Homo sapiens 126-130 9224210-2 1997 A coordinated upregulation of A alpha, B beta, and gamma chain FBG gene transcription occurs upon stimulation of A549 lung epithelial cells with dexamethasone (DEX) and the proinflammatory mediator interleukin-6 (IL-6). Dexamethasone 160-163 interleukin 6 Homo sapiens 213-217 9212236-7 1997 Growth of bladder carcinoma cells was significantly inhibited by anti-IL-6 neutralizing antibody or the anti-sense oligonucleotide for IL-6 cDNA. Oligonucleotides 115-130 interleukin 6 Homo sapiens 135-139 9256185-0 1997 Interleukin 6 and interferon-gamma gene expression in lung transplant recipients with refractory acute cellular rejection: implications for monitoring and inhibition by treatment with aerosolized cyclosporine. Cyclosporine 196-208 interleukin 6 Homo sapiens 0-13 9218571-0 1997 Melatonin enhances IL-2, IL-6, and IFN-gamma production by human circulating CD4+ cells: a possible nuclear receptor-mediated mechanism involving T helper type 1 lymphocytes and monocytes. Melatonin 0-9 interleukin 6 Homo sapiens 25-29 9218571-3 1997 Melatonin also enhances IL-6 production by PBMCs. Melatonin 0-9 interleukin 6 Homo sapiens 24-28 9218571-4 1997 The activation by melatonin of IL-6 production is apparently related to the presence of monocytes, rather than to Th2 cells, in the cell preparation, since PBMCs depleted of monocytes (CD14+ cells) were not activated. Melatonin 18-27 interleukin 6 Homo sapiens 31-35 18636446-2 1997 We have used antisense oligonucleotides to modulate the response of the hepatoma cell line, HepG2, to the inflammatory cytokine, IL-6, by inhibiting the expression of its multifunctional signal transducer, gp130. Oligonucleotides 23-39 interleukin 6 Homo sapiens 129-133 9212969-7 1997 These data demonstrated that in pediatric CPB, heparin-coated CPB circuits reduced the activation of complements and the production of PMN elastase and IL-6, suggesting the superior biocompatibility of the heparin-coated circuits. Heparin 47-54 interleukin 6 Homo sapiens 152-156 9329631-0 1997 Granulocyte-macrophage colony stimulating factor and interleukin-6 enhanced white blood cell synthesis of leukotrienes in chronic myelogenous leukemia. Leukotrienes 106-118 interleukin 6 Homo sapiens 53-66 9507569-7 1997 Exposure of cyclosporin A and dexamethasone almost completely inhibited the production of IL-6 and IL-8 after 24 hours of treatment. Cyclosporine 12-25 interleukin 6 Homo sapiens 90-94 9329631-1 1997 The effect of Granulocyte-Macrophage, Colony Stimulating Factor (GM-CSF) and Interleukin-6 (IL-6) on leukotriene production by CML white blood cells induced by calcium ionophore (A23187) was investigated and the leukotrienes formed were identified and quantified using high performance liquid chromatography (HPLC). Leukotrienes 101-112 interleukin 6 Homo sapiens 77-90 9329631-1 1997 The effect of Granulocyte-Macrophage, Colony Stimulating Factor (GM-CSF) and Interleukin-6 (IL-6) on leukotriene production by CML white blood cells induced by calcium ionophore (A23187) was investigated and the leukotrienes formed were identified and quantified using high performance liquid chromatography (HPLC). Leukotrienes 101-112 interleukin 6 Homo sapiens 92-96 9329631-1 1997 The effect of Granulocyte-Macrophage, Colony Stimulating Factor (GM-CSF) and Interleukin-6 (IL-6) on leukotriene production by CML white blood cells induced by calcium ionophore (A23187) was investigated and the leukotrienes formed were identified and quantified using high performance liquid chromatography (HPLC). Calcium 160-167 interleukin 6 Homo sapiens 92-96 9329631-3 1997 Although GM-CSF or IL-6 alone did not stimulate the synthesis of 5-lipoxygenase product, preincubation of the white blood cells of CML with GM-CSF or IL-6 for 30 minutes at 37 degrees C enhanced the ionophore A23187 induced leukotrienes synthesis, thus the CML white blood cell suspension primed with GM-CSF or IL-6 produced 26.6 +/- 2.8 and 18.9 +/- 1.3 pmol LTC4/10(6) cells respectively, and 30.2 +/- 3.6 and 25.5 +/- 2.5 Pmol LTB4/10(6) cells. Leukotrienes 224-236 interleukin 6 Homo sapiens 150-154 9329631-3 1997 Although GM-CSF or IL-6 alone did not stimulate the synthesis of 5-lipoxygenase product, preincubation of the white blood cells of CML with GM-CSF or IL-6 for 30 minutes at 37 degrees C enhanced the ionophore A23187 induced leukotrienes synthesis, thus the CML white blood cell suspension primed with GM-CSF or IL-6 produced 26.6 +/- 2.8 and 18.9 +/- 1.3 pmol LTC4/10(6) cells respectively, and 30.2 +/- 3.6 and 25.5 +/- 2.5 Pmol LTB4/10(6) cells. Leukotrienes 224-236 interleukin 6 Homo sapiens 150-154 9207463-0 1997 Interleukin-6 overcomes p21WAF1 upregulation and G1 growth arrest induced by dexamethasone and interferon-gamma in multiple myeloma cells. Dexamethasone 77-90 interleukin 6 Homo sapiens 0-13 9207463-4 1997 Dex induced G1 growth arrest in MM cells, whereas IL-6 facilitated G1 to S phase transition; moreover, the effect of Dex was blocked by IL-6. Dexamethasone 0-3 interleukin 6 Homo sapiens 136-140 9207463-4 1997 Dex induced G1 growth arrest in MM cells, whereas IL-6 facilitated G1 to S phase transition; moreover, the effect of Dex was blocked by IL-6. Dexamethasone 117-120 interleukin 6 Homo sapiens 50-54 9207463-4 1997 Dex induced G1 growth arrest in MM cells, whereas IL-6 facilitated G1 to S phase transition; moreover, the effect of Dex was blocked by IL-6. Dexamethasone 117-120 interleukin 6 Homo sapiens 136-140 9207463-6 1997 Its expression was upregulated by Dex and downregulated by IL-6; again, IL-6 inhibited the increase in p21 triggered by Dex. Dexamethasone 34-37 interleukin 6 Homo sapiens 72-76 9207463-6 1997 Its expression was upregulated by Dex and downregulated by IL-6; again, IL-6 inhibited the increase in p21 triggered by Dex. Dexamethasone 120-123 interleukin 6 Homo sapiens 72-76 9207463-9 1997 Finally, interferon-gamma (IFN-gamma) also induced G1 growth arrest and upregulated p21 protein expression; as with Dex, affects of IFN-gamma were inhibited by IL-6. Dexamethasone 116-119 interleukin 6 Homo sapiens 160-164 9202212-3 1997 Using the tyrosine phosphorylation inhibitor, genistein, and electrophoretic mobility shift assay, we show that IL-6 and IFN-gamma induce nuclear factor STAT-3 and STAT-1 DNA-binding activity to the sis-inducible element of c-fos in a genistein-dependent pathway. Tyrosine 10-18 interleukin 6 Homo sapiens 112-116 9246192-6 1997 At the transcriptional level, a slight increase of IL-6 transcripts was already detectable 1 h after irradiation, with maximum levels at 2 h, and a decline to baseline levels between 8 and 24 h. Addition of the transcriptional inhibitor actinomycin D inhibited the inducibility of IL-6 mRNA by TPA and IR. Tetradecanoylphorbol Acetate 294-297 interleukin 6 Homo sapiens 51-55 9246192-7 1997 As the IL-6 promoter contains multiple binding sites for activated glucocorticoid receptors within the 5" regulatory region, the potential modulation of IL-6 expression by the corticosteroids hydrocortisone, dexamethasone and mometasone furoate was included in our study to modify the radiation-induced stress response. Hydrocortisone 192-206 interleukin 6 Homo sapiens 7-11 9246192-7 1997 As the IL-6 promoter contains multiple binding sites for activated glucocorticoid receptors within the 5" regulatory region, the potential modulation of IL-6 expression by the corticosteroids hydrocortisone, dexamethasone and mometasone furoate was included in our study to modify the radiation-induced stress response. Hydrocortisone 192-206 interleukin 6 Homo sapiens 153-157 9246192-7 1997 As the IL-6 promoter contains multiple binding sites for activated glucocorticoid receptors within the 5" regulatory region, the potential modulation of IL-6 expression by the corticosteroids hydrocortisone, dexamethasone and mometasone furoate was included in our study to modify the radiation-induced stress response. Dexamethasone 208-221 interleukin 6 Homo sapiens 7-11 9246192-7 1997 As the IL-6 promoter contains multiple binding sites for activated glucocorticoid receptors within the 5" regulatory region, the potential modulation of IL-6 expression by the corticosteroids hydrocortisone, dexamethasone and mometasone furoate was included in our study to modify the radiation-induced stress response. Dexamethasone 208-221 interleukin 6 Homo sapiens 153-157 9246192-8 1997 All corticosteroids applied could efficiently downregulate TPA- or radiation-induced IL-6 expression on both gene expression and protein levels. Tetradecanoylphorbol Acetate 59-62 interleukin 6 Homo sapiens 85-89 9253906-6 1997 Interleukin-6 was elevated and correlated with rectal temperature and nitrogen excretion in both groups. Nitrogen 70-78 interleukin 6 Homo sapiens 0-13 9199351-3 1997 We demonstrate that RA and its synthetic analogs inhibit the proliferation of KS cells by inhibiting the mRNA and protein levels of interleukin-6 (IL-6), an autocrine growth factor for KS cells. Tretinoin 20-22 interleukin 6 Homo sapiens 132-145 9199351-3 1997 We demonstrate that RA and its synthetic analogs inhibit the proliferation of KS cells by inhibiting the mRNA and protein levels of interleukin-6 (IL-6), an autocrine growth factor for KS cells. Tretinoin 20-22 interleukin 6 Homo sapiens 147-151 18406806-5 1997 IL-6 and NGF can rapidly increase lipolysis and hepatic triglyceride secretion without inducing hyperglycemia. Triglycerides 56-68 interleukin 6 Homo sapiens 0-4 9507569-7 1997 Exposure of cyclosporin A and dexamethasone almost completely inhibited the production of IL-6 and IL-8 after 24 hours of treatment. Dexamethasone 30-43 interleukin 6 Homo sapiens 90-94 9138093-14 1997 Although most of these responses appeared to be unaffected by the steroid, 17 beta-E2 suppressed parathyroid hormone-induced cAMP production, as well as basal interleukin-6 mRNA expression; conversely, the steroid upregulated the steady-state expression of alkaline phosphatase message in these cells. Steroids 206-213 interleukin 6 Homo sapiens 159-172 9185506-5 1997 Administration of dexamethasone to temporal artery-SCID chimeras for 1 wk induced a partial suppression of T cell and macrophage function as indicated by the reduced tissue concentrations of IL-2, IL-1beta, and IL-6 mRNA, and by the diminished expression of inducible NO synthase. Dexamethasone 18-31 interleukin 6 Homo sapiens 211-215 9171095-2 1997 We have previously shown that the effects of TNFalphaand estradiol on the human IL-6 promoter were dependent on a region of the promoter containing a C/EBP site and a NF-kappaB site. Estradiol 57-66 interleukin 6 Homo sapiens 80-84 9199508-0 1997 Repression of interleukin-6 gene expression by 17 beta-estradiol: inhibition of the DNA-binding activity of the transcription factors NF-IL6 and NF-kappa B by the estrogen receptor. Estradiol 54-64 interleukin 6 Homo sapiens 14-27 9199508-3 1997 In the endometrial adenocarcinoma cell line Ishikawa, phorbol ester-induced activation of the IL-6 promoter was inhibited to basal levels by 17 beta-estradiol (E2) in a wild-type receptor-dependent fashion. Estradiol 141-158 interleukin 6 Homo sapiens 94-98 9212976-5 1997 In hyperosmotic 150 mM NaCl or 1.0 M glycerol medium, the stress response to heat shock was inhibited at the levels of HSF activation, HSP70 mRNA accumulation, and HSP70 synthesis. Sodium Chloride 23-27 interleukin 6 Homo sapiens 119-122 9212976-6 1997 In vitro activation of HSF showed that inhibition of this activation by hyperosmotic NaCl or glycerol stress was not irreversible. Sodium Chloride 85-89 interleukin 6 Homo sapiens 23-26 9169347-5 1997 Agonists for protein kinase A (PKA) (forskolin), and protein kinase C (PKC) (phorbol 12-myristate 13-acetate; PMA) also stimulated IL-6/IL-11 production. Tetradecanoylphorbol Acetate 77-108 interleukin 6 Homo sapiens 131-135 9184643-11 1997 These results demonstrated that CT can induce IL-6 production via cAMP accumulation and the effects of CT are mediated via its own receptors. Cyclic AMP 66-70 interleukin 6 Homo sapiens 46-50 9169347-6 1997 Rp-diastereoisomer of adenosine cyclic 3",5"-phosphorothioate (Rp-cAMPS) and H-8, inhibitors of PKA, significantly inhibited PTH-stimulated IL-6/IL-11 production, but did not inhibit IL-1-stimulated IL-6/IL-11 production. N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide 77-80 interleukin 6 Homo sapiens 140-144 9169347-6 1997 Rp-diastereoisomer of adenosine cyclic 3",5"-phosphorothioate (Rp-cAMPS) and H-8, inhibitors of PKA, significantly inhibited PTH-stimulated IL-6/IL-11 production, but did not inhibit IL-1-stimulated IL-6/IL-11 production. N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide 77-80 interleukin 6 Homo sapiens 199-203 9169347-8 1997 Pretreatment of cells with 17 beta-estradiol (17 beta-E2) antagonized IL-1-stimulated IL-6 production. Estradiol 27-44 interleukin 6 Homo sapiens 86-90 9169347-10 1997 Similarly, 17 beta-E2 inhibited PMA-stimulated IL-6 production, whereas neither forskolin-stimulated IL-6/ IL-11 production nor PMA-stimulated IL-11 production was affected by 17 beta-E2. Tetradecanoylphorbol Acetate 32-35 interleukin 6 Homo sapiens 47-51 9164976-6 1997 Immunoblot analysis revealed sIL-6R alpha/IL-6- or OM-induced tyrosine phosphorylation of a similar set of proteins in KS cells, and which was augmented significantly in Dex-treated KS cells. Tyrosine 62-70 interleukin 6 Homo sapiens 30-34 9164976-6 1997 Immunoblot analysis revealed sIL-6R alpha/IL-6- or OM-induced tyrosine phosphorylation of a similar set of proteins in KS cells, and which was augmented significantly in Dex-treated KS cells. Dexamethasone 170-173 interleukin 6 Homo sapiens 30-34 9164976-7 1997 Stimulation of KS cells with sIL-6R alpha/IL-6 or OM induced rapid tyrosine phosphorylation of the transcription factor STAT3, and Dex significantly enhanced the accumulation of tyrosine-phosphorylated STAT3. Tyrosine 67-75 interleukin 6 Homo sapiens 30-34 9164976-7 1997 Stimulation of KS cells with sIL-6R alpha/IL-6 or OM induced rapid tyrosine phosphorylation of the transcription factor STAT3, and Dex significantly enhanced the accumulation of tyrosine-phosphorylated STAT3. Dexamethasone 131-134 interleukin 6 Homo sapiens 30-34 9164976-7 1997 Stimulation of KS cells with sIL-6R alpha/IL-6 or OM induced rapid tyrosine phosphorylation of the transcription factor STAT3, and Dex significantly enhanced the accumulation of tyrosine-phosphorylated STAT3. Tyrosine 178-186 interleukin 6 Homo sapiens 30-34 9112422-7 1997 These findings indicate that IL-3 and IL-6 directly stimulate the steroidogenesis at the adrenal level through activation of different, cAMP-independent pathways. Cyclic AMP 136-140 interleukin 6 Homo sapiens 38-42 9217378-4 1997 These findings show that in replacement of thoracic aorta, pre-operative steroid administration decreases the post-operative elevations of serum inflammatory cytokines (IL-6 and IL-8) and may prevent organ injuries. Steroids 73-80 interleukin 6 Homo sapiens 169-173 9160463-15 1997 Blocking the biosynthesis of nitric oxide in interleukin-1 beta-stimulated disc cells provoked a large increase in the production of interleukin-6. Nitric Oxide 29-41 interleukin 6 Homo sapiens 133-146 9160463-19 1997 Endogenously produced nitric oxide appears to have a strong inhibitory effect on the production of interleukin-6, which suggests that autocrine mechanisms play an important role in the regulation of disc cell metabolism. Nitric Oxide 22-34 interleukin 6 Homo sapiens 99-112 9195137-4 1997 The IL-6 levels were lowest in the luteal phase when progesterone levels were elevated and highest preovulatory when progesterone levels were low (P < 0.009). Progesterone 53-65 interleukin 6 Homo sapiens 4-8 9195137-4 1997 The IL-6 levels were lowest in the luteal phase when progesterone levels were elevated and highest preovulatory when progesterone levels were low (P < 0.009). Progesterone 117-129 interleukin 6 Homo sapiens 4-8 9217378-0 1997 [Effects of pre-operative administration of steroids on the serum interleukin (IL)-6, IL-8 and organ injuries in replacement of thoracic aorta]. Steroids 44-52 interleukin 6 Homo sapiens 66-84 9217378-1 1997 To investigate whether pre-operative steroids administration decreases the post-operative serum IL-6, IL-8 and prevents organ injuries, we prospectively studied patients undergoing elective replacement of thoracic aorta using an extracorporeal circulation. Steroids 37-45 interleukin 6 Homo sapiens 96-100 9159271-4 1997 Moreover, in laboratory animal species, IL-1, IL-6, and TNF-alpha have been found to modulate intermediary metabolism of carbohydrate, fat, and protein substrates, regulate hypothalamic-pituitary outflow, and act in the brain to reduce food intake. Carbohydrates 121-133 interleukin 6 Homo sapiens 46-50 9500150-11 1997 Pretreatment of C6 glioma cells with 1 microM phorbol myristate acetate (PMA) for 24 h completely blocked the subsequent stimulation of IL-6 release by PMA (20-250 nM) and partially blocked by 50% the TF5 stimulation of this cytokine. Tetradecanoylphorbol Acetate 46-71 interleukin 6 Homo sapiens 136-140 9134917-5 1997 The immediate postrun plasma glucose concentrations correlated negatively with those of plasma cortisol (r = -0.67, P < 0.001); postrun plasma cortisol (r = 0.70, P < 0.001) and IL-6 levels (r = 0.54, P = 0.003) correlated positively with levels of IL-1ra. Glucose 29-36 interleukin 6 Homo sapiens 184-188 9126968-7 1997 IL-6 was shown to promote the rapid tyrosine phosphorylation of gp130, Jak2, and Shc proteins. Tyrosine 36-44 interleukin 6 Homo sapiens 0-4 9500150-11 1997 Pretreatment of C6 glioma cells with 1 microM phorbol myristate acetate (PMA) for 24 h completely blocked the subsequent stimulation of IL-6 release by PMA (20-250 nM) and partially blocked by 50% the TF5 stimulation of this cytokine. Tetradecanoylphorbol Acetate 73-76 interleukin 6 Homo sapiens 136-140 9500150-11 1997 Pretreatment of C6 glioma cells with 1 microM phorbol myristate acetate (PMA) for 24 h completely blocked the subsequent stimulation of IL-6 release by PMA (20-250 nM) and partially blocked by 50% the TF5 stimulation of this cytokine. Tetradecanoylphorbol Acetate 152-155 interleukin 6 Homo sapiens 136-140 9184420-3 1997 The IL-6/sIL-6R complex was also able to rapidly induce tyrosine phosphorylation of the IL-6 transducer, gp130. Tyrosine 56-64 interleukin 6 Homo sapiens 4-8 9184420-3 1997 The IL-6/sIL-6R complex was also able to rapidly induce tyrosine phosphorylation of the IL-6 transducer, gp130. Tyrosine 56-64 interleukin 6 Homo sapiens 10-14 9144567-2 1997 In cycloheximide or anisomycin treated cells, the accumulation of the IL-6 message and the activation of transcription factors required for IL-6 gene expression occurs at an extent similar to that obtained with IL-1beta. Anisomycin 20-30 interleukin 6 Homo sapiens 70-74 9144567-0 1997 Protein synthesis inhibitors cycloheximide and anisomycin induce interleukin-6 gene expression and activate transcription factor NF-kappaB. Anisomycin 47-57 interleukin 6 Homo sapiens 65-78 9144567-2 1997 In cycloheximide or anisomycin treated cells, the accumulation of the IL-6 message and the activation of transcription factors required for IL-6 gene expression occurs at an extent similar to that obtained with IL-1beta. Anisomycin 20-30 interleukin 6 Homo sapiens 140-144 9144567-1 1997 In two human cell lines, MDA-MB-231 and HeLa, the inducible expression of the interleukin-6 (IL-6) gene by two protein synthesis inhibitors, cycloheximide and anisomycin, was compared with the induction by the most potent physiological inducer of IL-6 described to date, interleukin-1beta (IL-1beta). Anisomycin 159-169 interleukin 6 Homo sapiens 78-91 9144567-1 1997 In two human cell lines, MDA-MB-231 and HeLa, the inducible expression of the interleukin-6 (IL-6) gene by two protein synthesis inhibitors, cycloheximide and anisomycin, was compared with the induction by the most potent physiological inducer of IL-6 described to date, interleukin-1beta (IL-1beta). Anisomycin 159-169 interleukin 6 Homo sapiens 93-97 9144567-3 1997 Furthermore, IL-6 mRNA accumulation stimulated by cycloheximide or anisomycin is almost completely inhibited in the presence of actinomycin D, indicating that this effect occurs mainly through the activation of the transcriptional machinery. Anisomycin 67-77 interleukin 6 Homo sapiens 13-17 9161853-2 1997 We measured creatinine-collected urinary levels of IL-6 and IL-8 by an enzyme-linked immunosorbent assay in 21 women with urethritis syndrome as well as 20 age-matched healthy women. Creatinine 12-22 interleukin 6 Homo sapiens 51-55 9092685-3 1997 The finding that endogenous IL-6 levels in serum increased after 5-fluorouracil (5-FU) treatment suggests that IL-6 may play some role in the recovery of hematopoietic systems. Fluorouracil 65-79 interleukin 6 Homo sapiens 28-32 9092685-3 1997 The finding that endogenous IL-6 levels in serum increased after 5-fluorouracil (5-FU) treatment suggests that IL-6 may play some role in the recovery of hematopoietic systems. Fluorouracil 65-79 interleukin 6 Homo sapiens 111-115 9092685-3 1997 The finding that endogenous IL-6 levels in serum increased after 5-fluorouracil (5-FU) treatment suggests that IL-6 may play some role in the recovery of hematopoietic systems. Fluorouracil 81-85 interleukin 6 Homo sapiens 28-32 9092685-3 1997 The finding that endogenous IL-6 levels in serum increased after 5-fluorouracil (5-FU) treatment suggests that IL-6 may play some role in the recovery of hematopoietic systems. Fluorouracil 81-85 interleukin 6 Homo sapiens 111-115 9097927-5 1997 Dexamethasone had an enhancing effect on IL-6-induced expression of HP and ACH, but inhibited sPLA2 expression by 50%. Dexamethasone 0-13 interleukin 6 Homo sapiens 41-45 9097927-8 1997 Although dexamethasone potentiated IL-6-induced APP expression in HepG2 cells, it suppressed sPLA2 expression in a dose-dependent manner. Dexamethasone 9-22 interleukin 6 Homo sapiens 35-39 9114781-1 1997 In a group of patients with New York Heart Association class IV heart failure, significant relations between interleukin-6 and tumor necrosis factor-alpha, and between levels of both interleukin-6 and tumor necrosis factor-alpha and plasma levels of norepinephrine were observed. Norepinephrine 250-264 interleukin 6 Homo sapiens 109-154 9114781-1 1997 In a group of patients with New York Heart Association class IV heart failure, significant relations between interleukin-6 and tumor necrosis factor-alpha, and between levels of both interleukin-6 and tumor necrosis factor-alpha and plasma levels of norepinephrine were observed. Norepinephrine 250-264 interleukin 6 Homo sapiens 183-228 9154298-13 1997 The increase in IL-6 luciferase activity occurs in the absence of the multiple response region, the area of the IL-6 promoter responsive to IL-1, TNF alpha, cyclic amp, and phorbol 12-myristate 13-acetate. Cyclic AMP 157-167 interleukin 6 Homo sapiens 16-20 9154298-13 1997 The increase in IL-6 luciferase activity occurs in the absence of the multiple response region, the area of the IL-6 promoter responsive to IL-1, TNF alpha, cyclic amp, and phorbol 12-myristate 13-acetate. Cyclic AMP 157-167 interleukin 6 Homo sapiens 112-116 9154298-13 1997 The increase in IL-6 luciferase activity occurs in the absence of the multiple response region, the area of the IL-6 promoter responsive to IL-1, TNF alpha, cyclic amp, and phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 173-204 interleukin 6 Homo sapiens 16-20 9154298-13 1997 The increase in IL-6 luciferase activity occurs in the absence of the multiple response region, the area of the IL-6 promoter responsive to IL-1, TNF alpha, cyclic amp, and phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 173-204 interleukin 6 Homo sapiens 112-116 9410612-6 1997 IL-6, however, displayed a positive reaction only in the control group, while it was invisible in the group of patients with CsA medication. Cyclosporine 125-128 interleukin 6 Homo sapiens 0-4 9093798-4 1997 A negative correlation was found between IL-6 and serum estradiol, as well as between IL-6 and bone density in 5 out of 6 sites studied. Estradiol 56-65 interleukin 6 Homo sapiens 41-45 9083891-0 1997 Modification of in vivo and in vitro TNF-alpha, IL-1, and IL-6 secretion by circulating monocytes during hyperbaric oxygen treatment in patients with perianal Crohn"s disease. Oxygen 116-122 interleukin 6 Homo sapiens 58-62 9086301-1 1997 This study examined the effect of the angiotensin converting enzyme (ACE) inhibitor, enalaprilat, on mesangial cell (MC) DNA synthesis induced by H2O2, IL-6 and PDGF. Enalaprilat 85-96 interleukin 6 Homo sapiens 152-156 9086301-5 1997 Stimulation of MC by H2O2, PDGF and IL-6 alone resulted in increases in 3H-TdR of 4936.6 +/- 1147.5, 5640.5 +/- 1537.6 and 4413.5 +/- 998.4 cpm, respectively (P < 0.05 above control). Tritium 72-74 interleukin 6 Homo sapiens 36-40 9086301-6 1997 Only 2.5 mumol/l enalaprilat effected a significant reduction in IL-6 and PDGF-induced DNA synthesis. Enalaprilat 17-28 interleukin 6 Homo sapiens 65-69 9086301-7 1997 Incubation of MC with H2O2 + PDGF or H2O2 + IL-6 resulted in increases of 3H-TdR of 6471.9 +/- 1785.1 and 5507.2 +/- 1270 cpm, respectively (P < 0.05 above control). Hydrogen Peroxide 37-41 interleukin 6 Homo sapiens 44-48 9086301-7 1997 Incubation of MC with H2O2 + PDGF or H2O2 + IL-6 resulted in increases of 3H-TdR of 6471.9 +/- 1785.1 and 5507.2 +/- 1270 cpm, respectively (P < 0.05 above control). Tritium 74-76 interleukin 6 Homo sapiens 44-48 9086301-8 1997 Addition of enalaprilat with either H2O2 + PDGF or H2O2 + IL-6 effected significant reductions in DNA synthesis over the range 2.5-100 mumol/l. Enalaprilat 12-23 interleukin 6 Homo sapiens 58-62 9125669-4 1997 IL-1, a physiological activator of PKC, induced a rapid increase in IL-6 messenger RNA (mRNA) levels, which was sustained at 24 h. PMA-induced IL-6 mRNA levels in RASMC were markedly attenuated after downregulation of PKC with PMA and by the selective PKC inhibitor, bisindolylmaleimide. Tetradecanoylphorbol Acetate 131-134 interleukin 6 Homo sapiens 68-72 9125669-4 1997 IL-1, a physiological activator of PKC, induced a rapid increase in IL-6 messenger RNA (mRNA) levels, which was sustained at 24 h. PMA-induced IL-6 mRNA levels in RASMC were markedly attenuated after downregulation of PKC with PMA and by the selective PKC inhibitor, bisindolylmaleimide. Tetradecanoylphorbol Acetate 131-134 interleukin 6 Homo sapiens 143-147 9125669-4 1997 IL-1, a physiological activator of PKC, induced a rapid increase in IL-6 messenger RNA (mRNA) levels, which was sustained at 24 h. PMA-induced IL-6 mRNA levels in RASMC were markedly attenuated after downregulation of PKC with PMA and by the selective PKC inhibitor, bisindolylmaleimide. Tetradecanoylphorbol Acetate 227-230 interleukin 6 Homo sapiens 68-72 9125669-4 1997 IL-1, a physiological activator of PKC, induced a rapid increase in IL-6 messenger RNA (mRNA) levels, which was sustained at 24 h. PMA-induced IL-6 mRNA levels in RASMC were markedly attenuated after downregulation of PKC with PMA and by the selective PKC inhibitor, bisindolylmaleimide. Tetradecanoylphorbol Acetate 227-230 interleukin 6 Homo sapiens 143-147 9410612-1 1997 In vitro studies on epithelial cells suggest that cyclosporin (CsA) inhibits a pathway of production of IL-6, which is mediated by TNF alpha and E. coli. Cyclosporine 50-61 interleukin 6 Homo sapiens 104-108 9410612-1 1997 In vitro studies on epithelial cells suggest that cyclosporin (CsA) inhibits a pathway of production of IL-6, which is mediated by TNF alpha and E. coli. Cyclosporine 63-66 interleukin 6 Homo sapiens 104-108 9089795-7 1997 In vitro IL-6 production was stimulated by PGE2 in alloactivated cultures and by iloprost, whatever the stimulus. Dinoprostone 43-47 interleukin 6 Homo sapiens 9-13 9089795-9 1997 After complete removal of monocytes from cell cultures, there were inhibitory effects of lloprost and PGE2 on IL-6 released in the supernatants. Dinoprostone 102-106 interleukin 6 Homo sapiens 110-114 9062617-0 1997 The effect of cortisol suppression on interleukin-6 and white blood cell responses to surgery. Hydrocortisone 14-22 interleukin 6 Homo sapiens 38-51 9033263-1 1997 High-resolution analyses of interleukin-6 mRNA in paraffin sections of lymph nodes. Paraffin 50-58 interleukin 6 Homo sapiens 28-41 9041915-11 1997 The responses of IL-6 and IL-1 beta in group 1 were striking compared with those in group 2, and they were accompanied by an elevation of the endotoxin concentration and a subsequent elevation of the concentrations of hepatocyte growth factor, hyaluronic acid, lactate, and other factors that reflected graft viability. Lactic Acid 261-268 interleukin 6 Homo sapiens 17-21 9003059-0 1997 Prostaglandin E2 induces interleukin-6 synthesis in human astrocytoma cells. Dinoprostone 0-16 interleukin 6 Homo sapiens 25-38 9041054-0 1997 Regulation of interleukin-6 secretion from mononuclear blood cells by extracellular calcium. Calcium 84-91 interleukin 6 Homo sapiens 14-27 9041054-3 1997 We recently reported that the calcium concentration in plasma affects IL-6 secretion from mononuclear blood cells. Calcium 30-37 interleukin 6 Homo sapiens 70-74 9041054-4 1997 To investigate the underlying mechanism, we have studied the effect of calcium on IL-6 formation in mononuclear blood cells ex vivo and in vitro. Calcium 71-78 interleukin 6 Homo sapiens 82-86 9041054-8 1997 IL-6 secretion ex vivo from mononuclear blood cells drawn 4 h after calcium intake was increased 185% as compared with IL-6 secretion from cells drawn just before calcium intake. Calcium 68-75 interleukin 6 Homo sapiens 0-4 9041054-8 1997 IL-6 secretion ex vivo from mononuclear blood cells drawn 4 h after calcium intake was increased 185% as compared with IL-6 secretion from cells drawn just before calcium intake. Calcium 163-170 interleukin 6 Homo sapiens 0-4 9041054-10 1997 In vitro studies revealed that stimulation of isolated mononuclear blood cells with physiological concentrations of calcium dose-dependently increased IL-6 secretion with an estimated EC50 at 1.2 mM Ca2+. Calcium 116-123 interleukin 6 Homo sapiens 151-155 9041054-12 1997 These observations demonstrate that the plasma calcium concentration affects IL-6 secretion from mononuclear blood cells. Calcium 47-54 interleukin 6 Homo sapiens 77-81 9056995-0 1997 Effects of dexamethasone and interleukin-6 on urea production by human hepatocytes in vitro. Urea 46-50 interleukin 6 Homo sapiens 29-42 9162741-2 1997 In a previous study, we investigated the effect of various cytokines on triacylglycerol and apoB secretion by CaCo-2 cells and observed that TNF-alpha, IL-1 beta, and particularly IL-6, decreased apolipoprotein (apo) B and triacylglycerol secretion. Triglycerides 72-87 interleukin 6 Homo sapiens 180-184 9162741-2 1997 In a previous study, we investigated the effect of various cytokines on triacylglycerol and apoB secretion by CaCo-2 cells and observed that TNF-alpha, IL-1 beta, and particularly IL-6, decreased apolipoprotein (apo) B and triacylglycerol secretion. Triglycerides 223-238 interleukin 6 Homo sapiens 180-184 9003059-1 1997 Prostaglandins (PGs) and cytokines, such as interleukin-1 (IL-1) and interleukin-6 (IL-6), have been implicated in the etiopathology of various inflammatory and degenerative disorders, including Alzheimer"s disease (AD) and prion diseases. Prostaglandins 0-14 interleukin 6 Homo sapiens 69-82 9003059-1 1997 Prostaglandins (PGs) and cytokines, such as interleukin-1 (IL-1) and interleukin-6 (IL-6), have been implicated in the etiopathology of various inflammatory and degenerative disorders, including Alzheimer"s disease (AD) and prion diseases. Prostaglandins 0-14 interleukin 6 Homo sapiens 84-88 9003059-1 1997 Prostaglandins (PGs) and cytokines, such as interleukin-1 (IL-1) and interleukin-6 (IL-6), have been implicated in the etiopathology of various inflammatory and degenerative disorders, including Alzheimer"s disease (AD) and prion diseases. Prostaglandins 16-19 interleukin 6 Homo sapiens 84-88 9003059-4 1997 PGE1 and PGE2, but not PGD2 and PGF2 alpha, led to a rapid and transient induction of IL-6 mRNA, followed by IL-6 protein synthesis. Dinoprostone 9-13 interleukin 6 Homo sapiens 86-90 9003059-4 1997 PGE1 and PGE2, but not PGD2 and PGF2 alpha, led to a rapid and transient induction of IL-6 mRNA, followed by IL-6 protein synthesis. Dinoprostone 9-13 interleukin 6 Homo sapiens 109-113 9003059-5 1997 Furthermore, PGE2 potentiated IL-1 beta-induced IL-6 mRNA synthesis. Dinoprostone 13-17 interleukin 6 Homo sapiens 48-52 8998126-9 1997 These fatty acids also reversed the inhibitory effect of interleukin-6 on prealbumin production. Fatty Acids 6-17 interleukin 6 Homo sapiens 57-70 9547608-6 1997 The addition of n-3 PUFAs in culture medium (100 ug/ml DHA or EPA) significantly reduces the production of IL-6 by unstimulated EC; or stimulated with TNF-alpha; IL-4 pg/ml); LPS or depleted PBL respectively for DHA and EPA, whereas the n-6 PUFAs (Arachidonic acid), even used at the highest concentration, was ineffective. dehydroacetic acid 55-58 interleukin 6 Homo sapiens 107-111 9547608-6 1997 The addition of n-3 PUFAs in culture medium (100 ug/ml DHA or EPA) significantly reduces the production of IL-6 by unstimulated EC; or stimulated with TNF-alpha; IL-4 pg/ml); LPS or depleted PBL respectively for DHA and EPA, whereas the n-6 PUFAs (Arachidonic acid), even used at the highest concentration, was ineffective. dehydroacetic acid 212-215 interleukin 6 Homo sapiens 107-111 9547608-6 1997 The addition of n-3 PUFAs in culture medium (100 ug/ml DHA or EPA) significantly reduces the production of IL-6 by unstimulated EC; or stimulated with TNF-alpha; IL-4 pg/ml); LPS or depleted PBL respectively for DHA and EPA, whereas the n-6 PUFAs (Arachidonic acid), even used at the highest concentration, was ineffective. Arachidonic Acid 248-264 interleukin 6 Homo sapiens 107-111 9074948-3 1997 Generation of tumor necrosis factor-alpha, interleukin 1-beta, granulocyte-macrophage colony-stimulating factor and interleukin-6 from 10(-5) M Azeptin-treated PBL and human monocytes (HM) was decreased to approximately 1/3 to 2/3 of the control levels. azelastine 144-151 interleukin 6 Homo sapiens 116-129 9013873-0 1997 Vav is associated with signal transducing molecules gp130, Grb2 and Erk2, and is tyrosine phosphorylated in response to interleukin-6. Tyrosine 81-89 interleukin 6 Homo sapiens 120-133 9013873-2 1997 We show that interleukin-6 (IL-6) induces transient tyrosine phosphorylation of Vav in a human myeloma cell line, U266. Tyrosine 52-60 interleukin 6 Homo sapiens 13-26 9013873-2 1997 We show that interleukin-6 (IL-6) induces transient tyrosine phosphorylation of Vav in a human myeloma cell line, U266. Tyrosine 52-60 interleukin 6 Homo sapiens 28-32 9013873-3 1997 A membrane-distal part of the cytoplasmic region of gp130 is critical for association between Vav and gp130, and the IL-6-induced tyrosine phosphorylation of Vav. Tyrosine 130-138 interleukin 6 Homo sapiens 117-121 9321950-0 1997 Regulation of eicosanoid-like compound biosynthesis by IFN-gamma, IL-6, and EPA in human breast cancer cell line. Eicosanoids 14-24 interleukin 6 Homo sapiens 66-70 8978296-5 1997 Because interleukin-6 (IL-6) is a growth factor for MM cells and inhibits apoptosis induced by dexamethasone and serum starvation, we examined whether IL-6 affects anti-Fas MoAb-induced apoptosis and activation of SAPK or p38 MAPK in MM cells. Dexamethasone 95-108 interleukin 6 Homo sapiens 23-27 8978300-3 1997 IL-6 induced transient tyrosine phosphorylation of the IL-6-receptor signal-transducing subunit gp130, the gp130-associated protein tyrosine kinases Jak1,Jak2, and Tyk2, the phosphotyrosine phosphatase PTP1D/Syp, the adaptor protein Shc and the mitogen-activated protein kinase Erk2, and accumulation of GTP-bound p21ras. Guanosine Triphosphate 304-307 interleukin 6 Homo sapiens 0-4 8978300-3 1997 IL-6 induced transient tyrosine phosphorylation of the IL-6-receptor signal-transducing subunit gp130, the gp130-associated protein tyrosine kinases Jak1,Jak2, and Tyk2, the phosphotyrosine phosphatase PTP1D/Syp, the adaptor protein Shc and the mitogen-activated protein kinase Erk2, and accumulation of GTP-bound p21ras. Tyrosine 23-31 interleukin 6 Homo sapiens 0-4 8978300-3 1997 IL-6 induced transient tyrosine phosphorylation of the IL-6-receptor signal-transducing subunit gp130, the gp130-associated protein tyrosine kinases Jak1,Jak2, and Tyk2, the phosphotyrosine phosphatase PTP1D/Syp, the adaptor protein Shc and the mitogen-activated protein kinase Erk2, and accumulation of GTP-bound p21ras. Guanosine Triphosphate 304-307 interleukin 6 Homo sapiens 55-59 8978300-3 1997 IL-6 induced transient tyrosine phosphorylation of the IL-6-receptor signal-transducing subunit gp130, the gp130-associated protein tyrosine kinases Jak1,Jak2, and Tyk2, the phosphotyrosine phosphatase PTP1D/Syp, the adaptor protein Shc and the mitogen-activated protein kinase Erk2, and accumulation of GTP-bound p21ras. Tyrosine 23-31 interleukin 6 Homo sapiens 55-59 8978300-4 1997 Prior treatment of U266 cells with IFN-beta downregulated IL-6-induced tyrosine phosphorylation of gp130, Jak2, PTP1D/Syp, Shc, and Erk2, and GTP-loading of p21ras. Tyrosine 71-79 interleukin 6 Homo sapiens 58-62 8978300-4 1997 Prior treatment of U266 cells with IFN-beta downregulated IL-6-induced tyrosine phosphorylation of gp130, Jak2, PTP1D/Syp, Shc, and Erk2, and GTP-loading of p21ras. Guanosine Triphosphate 142-145 interleukin 6 Homo sapiens 58-62 9252193-1 1997 Alkaline phosphatase, a marker of differentiation in the human alveolar adenocarcinoma cell line A549, is inducible by conditioned medium from lung fibroblasts and by cytokines including oncostatin M and interleukin 6, but only in the presence of a glucocorticoid, dexamethasone. Dexamethasone 265-278 interleukin 6 Homo sapiens 204-217 8978300-5 1997 Further analysis indicated that treatment with IFN-beta disrupted IL-6-induced binding of PTP1D/Syp to gp130 and the adaptor protein Grb2; IFN-beta pretreatment also interfered with IL-6-induced interaction of Shc with Grb2 and a 145-kD tyrosine-phosphorylated protein. Tyrosine 237-245 interleukin 6 Homo sapiens 66-70 8978300-5 1997 Further analysis indicated that treatment with IFN-beta disrupted IL-6-induced binding of PTP1D/Syp to gp130 and the adaptor protein Grb2; IFN-beta pretreatment also interfered with IL-6-induced interaction of Shc with Grb2 and a 145-kD tyrosine-phosphorylated protein. Tyrosine 237-245 interleukin 6 Homo sapiens 182-186 18472849-2 1997 Phorbol-12-myristate 13 acetate (PMA) caused a decrease in the levels of IL-6 in 14 out of 16 cultures and an increase in levels of sIL6R in all 15 cases. Tetradecanoylphorbol Acetate 0-31 interleukin 6 Homo sapiens 73-77 9049837-5 1997 In addition, expression of IL-6 mRNA and peptide was increased by retinoic acid. Tretinoin 66-79 interleukin 6 Homo sapiens 27-31 8985427-6 1997 The viral counterpart of IL-6 (vIL-6) has conserved important features such as cysteine residues involved in disulfide bridging or an amino-terminal signal peptide. Cysteine 79-87 interleukin 6 Homo sapiens 25-29 8985427-6 1997 The viral counterpart of IL-6 (vIL-6) has conserved important features such as cysteine residues involved in disulfide bridging or an amino-terminal signal peptide. Disulfides 109-118 interleukin 6 Homo sapiens 25-29 9126869-0 1997 Cyclosporin-A inhibits human endothelial cells proliferation through interleukin-6-dependent mechanisms. Cyclosporine 0-13 interleukin 6 Homo sapiens 69-82 22358535-4 1997 These results clearly demonstrate that phosphatidylcholine-specific phospholipase C is a key molecule mediating insulin-induced enhancement of hIL-6 expression from the human cytomegalovirus promoter in Chinese hamster ovary cells and strongly suggest that it plays an important role in the insulin signaling pathways.Abbreviations CHO - Chinese hamster ovary; hCMV promoter - immediate early gene promoter of human cytomegalovirus; hIL-6 - human interleukin 6; PC-PLC-phosphatidylcholine-specific phospholipase C; PI-3 kinase - phosphoinositide 3 kinase; PKA - cAMP dependent protein kinase; PKC - protein kinase C. Cyclic AMP 562-566 interleukin 6 Homo sapiens 143-148 17265626-5 1997 In postmenopausal group, there was a negative significant correlation between estradiol level and both IL-6 and osteocalcin levels. Estradiol 78-87 interleukin 6 Homo sapiens 103-107 17265626-8 1997 When correlating the parameters of all the 46 patients, there was a highly negative significant correlation between estradiol level and IL-6 and a negative significant correlation between estradiol level and osteocalcin, while there was a positive significant correlation between osteocalcin and IL-6. Estradiol 116-125 interleukin 6 Homo sapiens 136-140 18472849-2 1997 Phorbol-12-myristate 13 acetate (PMA) caused a decrease in the levels of IL-6 in 14 out of 16 cultures and an increase in levels of sIL6R in all 15 cases. Tetradecanoylphorbol Acetate 33-36 interleukin 6 Homo sapiens 73-77 9346391-10 1997 Neutralizing antibody to IL-6 inhibited the effect of morphine on RMIC. Morphine 54-62 interleukin 6 Homo sapiens 25-29 9493287-4 1997 Addition of RA to lympho-stromal cell co-culture results in the enhancement of IL4 and IL7 expression in thymocytes while in thymic epithelial cells IL1 alpha decreased and IL6 and IL7 increased. Tretinoin 12-14 interleukin 6 Homo sapiens 173-176 9449167-5 1997 As a matter of fact, we demonstrated that Biafine is chemotactic for macrophages and increases the IL-1/IL-6 ratio, chiefly by reducing the secretion of IL-6. Biafine 42-49 interleukin 6 Homo sapiens 104-108 9449167-5 1997 As a matter of fact, we demonstrated that Biafine is chemotactic for macrophages and increases the IL-1/IL-6 ratio, chiefly by reducing the secretion of IL-6. Biafine 42-49 interleukin 6 Homo sapiens 153-157 9132617-12 1997 The finding that norepinephrine stimulates activated astrocytes to produce IL-6 implies that the cytokine cascade may be activated by neuronal processes under certain conditions. Norepinephrine 17-31 interleukin 6 Homo sapiens 75-79 16793656-7 1997 Finally, a statistical analysis of the population under study showed the presence of a significant correlation between elevated plasma IL-6 ( P < 0.001) and IL-1beta levels ( P < 0.007), and an increased sensitivity of platelets to arachidonic acid, suggesting a possible correlation between the inflammatory response and the prothrombotic state observed in patients with COPD. Arachidonic Acid 238-254 interleukin 6 Homo sapiens 135-139 8977259-0 1996 Myeloma cell growth arrest, apoptosis, and interleukin-6 receptor modulation induced by EB1089, a vitamin D3 derivative, alone or in association with dexamethasone. Dexamethasone 150-163 interleukin 6 Homo sapiens 43-56 8943271-4 1996 A construct (HSFDT385SH) of the heat shock transcription factor (HSF) was expressed that contains the DNA-binding and trimerization domains, residues 192-385 of HSF, with four additional COOH-terminal residues, GMLC, and then labeled at the COOH-terminal cysteine with fluorescein 5-maleimide to form HSFDT385-Fl. Cysteine 255-263 interleukin 6 Homo sapiens 32-63 8943271-4 1996 A construct (HSFDT385SH) of the heat shock transcription factor (HSF) was expressed that contains the DNA-binding and trimerization domains, residues 192-385 of HSF, with four additional COOH-terminal residues, GMLC, and then labeled at the COOH-terminal cysteine with fluorescein 5-maleimide to form HSFDT385-Fl. Cysteine 255-263 interleukin 6 Homo sapiens 65-68 9010683-6 1996 Treatment of THP-1 cells with PMA and LPS caused the highest production of both IL-1 beta and IL-6 (> 5ng/ml). Tetradecanoylphorbol Acetate 30-33 interleukin 6 Homo sapiens 94-98 8968107-9 1996 Exogenous IL-10, IL-6, IL-2, and TNF-alpha significantly enhanced the [3H]thymidine uptake in 13 of 13 (100%), 5 of 13 (38%), 9 of 13 (69%), and 2 of 10 (20%) PTCPs costimulated with anti-CD40, respectively. Tritium 71-73 interleukin 6 Homo sapiens 17-21 8982119-0 1996 Tumor necrosis factor-alpha, lymphotoxin, interleukin (IL)-6, IL-10, IL-12 and perforin mRNA expression in mononuclear cells in response to acetylcholine receptor is augmented in myasthenia gravis. Acetylcholine 140-153 interleukin 6 Homo sapiens 42-60 8945595-0 1996 Production of human tumor necrosis factor alpha, interleukin-6, and interleukin-10 is induced by lactic acid bacteria. Lactic Acid 97-108 interleukin 6 Homo sapiens 49-62 9172015-5 1996 In contrast, the stimulation of mRNA expression for IL-6 by Y-25510 was not suppressed by cycloheximide but suppressed by N alpha-p-tosyl-L-phenylalanine chloromethyl ketone (TPCK), an inhibitor of nuclear transcription factor-kappa B (NF-kappa B) activation, in the presence of LPS, suggesting that the stimulation requires NF-kappa activation. n alpha-p-tosyl-l-phenylalanine chloromethyl ketone 122-173 interleukin 6 Homo sapiens 52-56 9172015-7 1996 Dexamethasone suppressed the LPS-induced expression of mRNA for IL-1 beta and IL-6 in THP-1 cells, whereas the drug never suppressed the mRNA expression for these cytokines in the presence of Y-25510. Dexamethasone 0-13 interleukin 6 Homo sapiens 78-82 8953156-7 1996 The release of IL-2 and IL-6 by PHA-stimulated PBMC was significantly inhibited by titanium, chromium, and cobalt. Titanium 83-91 interleukin 6 Homo sapiens 24-28 8953156-9 1996 The addition of IL-2 and IL-6 significantly restored the metal-induced inhibition of T cell and B cell proliferation, respectively. Metals 57-62 interleukin 6 Homo sapiens 25-29 8982097-3 1996 To better understand the immunopathology of brain injury, we studied the role of inflammatory cytokines such as tumor necrosis factor alpha, interleukin (IL) 6, IL-2, interferon gamma and IL-1 beta in the production of arachidonic acid metabolites in cells from fetal human brain. Arachidonic Acid 219-235 interleukin 6 Homo sapiens 141-159 9139274-4 1996 Urinary excretion of IL-6 was significantly higher (p < 0.05) in IDDM patients with albuminuria (mean = 7.43 +/- 8.29 pg/mg creatinine) than in control group (mean = 3.74 +/- 2.64 pg/mg creatinine). Creatinine 127-137 interleukin 6 Homo sapiens 21-25 8943482-9 1996 IL-6 values: N, 2.04 +/- 0.51; IgAN Grades 1-2, 3.26 +/- 0.38; Grades 3-4, 5.67 +/- 0.92; Grade 5, 27.20 +/- 9.70 pg/mg urinary creatinine), that correlated with the degree of histological lesions, the presence of hypertension and serum creatinine level. Creatinine 128-138 interleukin 6 Homo sapiens 0-4 8943482-9 1996 IL-6 values: N, 2.04 +/- 0.51; IgAN Grades 1-2, 3.26 +/- 0.38; Grades 3-4, 5.67 +/- 0.92; Grade 5, 27.20 +/- 9.70 pg/mg urinary creatinine), that correlated with the degree of histological lesions, the presence of hypertension and serum creatinine level. Creatinine 237-247 interleukin 6 Homo sapiens 0-4 9139274-4 1996 Urinary excretion of IL-6 was significantly higher (p < 0.05) in IDDM patients with albuminuria (mean = 7.43 +/- 8.29 pg/mg creatinine) than in control group (mean = 3.74 +/- 2.64 pg/mg creatinine). Creatinine 189-199 interleukin 6 Homo sapiens 21-25 8990929-3 1996 Oligonucleotide TTTTCAATTCGAAGATGATT which contain the CpG motif in hexamer palindromic sequence segments in cloned DNA augmented the expression of ICAM-1 on the endothelial cells detected by FACS analysis and also augmented the gene expression of several cytokines such as interleukin-2, interleukin-6, interleukin-8 and tumor necrosis factor alpha. Oligonucleotides 0-15 interleukin 6 Homo sapiens 289-302 8920958-4 1996 The maximal IL-6-induced increase in IGFBP-1 was comparable to that observed with dexamethasone, and this increase was attenuated by diltiazem or dantrolene, both of which are known to reduce the cytosolic Ca2+ concentration. Dexamethasone 82-95 interleukin 6 Homo sapiens 12-16 8958270-12 1996 During the second week of acute steroid-resistant rejection and lethal infection, a significant rise in IL-1beta, IFN-gamma, and IL-6 was observed (P < or = 0.01 versus control groups). Steroids 32-39 interleukin 6 Homo sapiens 129-133 8950199-3 1996 Since reactive oxygen species (ROS) have been implicated in catabolic cytokine action and preliminary data suggested that catabolic cytokines such as TNF-alpha, IL-1 alpha, IL-1 beta and IL-6 are responsible for fibronectin fragment mediated damage, selected anti-oxidants (AOs) were tested as inhibitors of cytokine. Reactive Oxygen Species 6-29 interleukin 6 Homo sapiens 187-191 8950199-3 1996 Since reactive oxygen species (ROS) have been implicated in catabolic cytokine action and preliminary data suggested that catabolic cytokines such as TNF-alpha, IL-1 alpha, IL-1 beta and IL-6 are responsible for fibronectin fragment mediated damage, selected anti-oxidants (AOs) were tested as inhibitors of cytokine. Reactive Oxygen Species 31-34 interleukin 6 Homo sapiens 187-191 8901797-4 1996 This occurred despite high plasma interleukin 6 concentrations, a situation that usually elevates plasma ceruloplasmin and copper values. Copper 123-129 interleukin 6 Homo sapiens 34-47 8918592-7 1996 Exogenous IL-6 partially restored the impaired immunoglobulin production of testosterone-treated PBMC; IgG production in testosterone culture was increased by IL-6 from 35.6% to 66.5% of control and that of IgM was also increased from 38.9% to 71.2%, respectively. Testosterone 76-88 interleukin 6 Homo sapiens 10-14 8849407-5 1996 Incubation with titanium led to release of tumor necrosis factor (TNF) and IL-6. Titanium 16-24 interleukin 6 Homo sapiens 75-79 8977675-0 1996 Ethanol enhances the IFN-gamma, TGF-alpha and IL-6 secretion in psoriatic co-cultures. Ethanol 0-7 interleukin 6 Homo sapiens 46-50 8977675-7 1996 Treatment with ethanol elevated slightly the IL-6 levels in the monocultures from psoriatic and control keratinocytes to 125% but not in HUT 78 monocultures. Ethanol 15-22 interleukin 6 Homo sapiens 45-49 8896407-10 1996 The addition of an angiogenic growth factor mixture including erythropoietin, interleukin-6, fibroblast growth factor 2, and vascular endothelial growth factor in the EB culture medium significantly increased the development of primitive vascular-like structures within EBs. eb culture 167-177 interleukin 6 Homo sapiens 78-91 8896414-4 1996 Both PDTC and NAC inhibited, in a dose-dependent manner, the synthesis of IL-6, IL-8, and GM-CSF induced by tumor necrosis factor (TNF)-alpha or bacterial lipopolysaccharides (LPS) in human umbilical vein endothelial cells (HUVEC). Acetylcysteine 14-17 interleukin 6 Homo sapiens 74-78 8918592-7 1996 Exogenous IL-6 partially restored the impaired immunoglobulin production of testosterone-treated PBMC; IgG production in testosterone culture was increased by IL-6 from 35.6% to 66.5% of control and that of IgM was also increased from 38.9% to 71.2%, respectively. Testosterone 76-88 interleukin 6 Homo sapiens 159-163 8918592-7 1996 Exogenous IL-6 partially restored the impaired immunoglobulin production of testosterone-treated PBMC; IgG production in testosterone culture was increased by IL-6 from 35.6% to 66.5% of control and that of IgM was also increased from 38.9% to 71.2%, respectively. Testosterone 121-133 interleukin 6 Homo sapiens 10-14 8918592-7 1996 Exogenous IL-6 partially restored the impaired immunoglobulin production of testosterone-treated PBMC; IgG production in testosterone culture was increased by IL-6 from 35.6% to 66.5% of control and that of IgM was also increased from 38.9% to 71.2%, respectively. Testosterone 121-133 interleukin 6 Homo sapiens 159-163 8918592-8 1996 Testosterone treatment reduced IL-6 production of monocytes by 78.4% compared with control, but neither affected that of T cells or B cells. Testosterone 0-12 interleukin 6 Homo sapiens 31-35 8918592-9 1996 These results suggest that testosterone may suppress immunoglobulin production of human PBMC directly by inhibiting B cell activity and indirectly by reducing IL-6 production of monocytes. Testosterone 27-39 interleukin 6 Homo sapiens 159-163 8982293-3 1996 After 5 d exposure to ATRA 10(-6) M APL-treated samples showed a significant reduction of IL-6 (p = 0.008) and GM-CSF (p = 0.03) and a significant increase of IL-1 alpha (p = 0.01) production, if compared to untreated APL samples. Tretinoin 22-26 interleukin 6 Homo sapiens 90-94 8912909-0 1996 Human olfactory neuroepithelial cells: tyrosine phosphorylation and process extension are increased by the combination of IL-1beta, IL-6, NGF, and bFGF. Tyrosine 39-47 interleukin 6 Homo sapiens 132-136 8933043-4 1996 We observed the beryllium-stimulated release of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-2 (IL-2), and interferon-gamma (IFN-gamma) but not interleukin-4 (IL-4). Beryllium 16-25 interleukin 6 Homo sapiens 89-102 8933043-4 1996 We observed the beryllium-stimulated release of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-2 (IL-2), and interferon-gamma (IFN-gamma) but not interleukin-4 (IL-4). Beryllium 16-25 interleukin 6 Homo sapiens 104-108 8969952-4 1996 Possible effects of IL-6 on steroid release were tested by incubating human adrenal cells in vitro with IL-6 [10(-8) M]. Steroids 28-35 interleukin 6 Homo sapiens 104-108 8969952-5 1996 Adrenal steroids were stimulated by IL-6: aldosterone 184 +/- 23, cortisol 198 +/- 19, DHEA 140 +/- 8 and androstenedione 136 +/- 5 (results are means +/- s.e.m. Steroids 8-16 interleukin 6 Homo sapiens 36-40 8923461-4 1996 These act to mediate the action of interleukin-6 and related cytokines to stimulate aromatase expression in the presence of DEX. Dexamethasone 124-127 interleukin 6 Homo sapiens 35-48 8906207-5 1996 Among mast-cell mediators, histamine was already known to induce a rapid and transient expression of P-selectin; we demonstrated that histamine also induced an IL-6 and IL-8 secretion by HUVEC, which was concentration-dependent and inhibited by H1 or H2 receptor antagonists. Histamine 27-36 interleukin 6 Homo sapiens 160-164 8906207-5 1996 Among mast-cell mediators, histamine was already known to induce a rapid and transient expression of P-selectin; we demonstrated that histamine also induced an IL-6 and IL-8 secretion by HUVEC, which was concentration-dependent and inhibited by H1 or H2 receptor antagonists. Histamine 134-143 interleukin 6 Homo sapiens 160-164 8898173-7 1996 The antisense oligonucleotides targeting IL-6 mRNA, however, inhibited both cell growth and IL-6 production. Oligonucleotides 14-30 interleukin 6 Homo sapiens 41-45 8898173-7 1996 The antisense oligonucleotides targeting IL-6 mRNA, however, inhibited both cell growth and IL-6 production. Oligonucleotides 14-30 interleukin 6 Homo sapiens 92-96 8898173-9 1996 The results also suggest that the therapeutic trials with monoclonal antibodies designed to neutralize IL-6 or block its receptor will likely fail, whereas the antisense oligonucleotides targeted to IL-6 mRNA may have some value for the treatment of choriocarcinoma and other cancers with intracellular autocrine growth fashion mediated by IL-6. Oligonucleotides 170-186 interleukin 6 Homo sapiens 199-203 8943541-9 1996 Either spontaneous or cytokine-induced IL-6 secretion was inhibited by progesterone (10(-8)-10(-5) M) and danazol (10(-6) M), whereas oestradiol (10(-8)-10(-5) M) had a limited inhibitory effect. Progesterone 71-83 interleukin 6 Homo sapiens 39-43 8898173-9 1996 The results also suggest that the therapeutic trials with monoclonal antibodies designed to neutralize IL-6 or block its receptor will likely fail, whereas the antisense oligonucleotides targeted to IL-6 mRNA may have some value for the treatment of choriocarcinoma and other cancers with intracellular autocrine growth fashion mediated by IL-6. Oligonucleotides 170-186 interleukin 6 Homo sapiens 199-203 8822942-6 1996 Importantly, culture of MM cells with RB antisense, but not RB sense, oligonucleotide (ODN) triggered IL-6 secretion and proliferation in MM cells; however, proliferation was only partially inhibited by neutralizing anti-IL-6 monoclonal antibody (MoAb). Oligonucleotides 70-85 interleukin 6 Homo sapiens 102-106 8798409-1 1996 We reported recently that angiotensin II (AII) and phorbol 12-myristate 13-acetate (PMA) transiently inhibit interleukin 6 (IL-6)-stimulated tyrosine phosphorylation of signal transducers and activators of transcription 3 (Stat3) and subsequent formation of sis-inducing factor-A (SIF-A). Tyrosine 141-149 interleukin 6 Homo sapiens 109-122 8964084-7 1996 HA1004, an inhibitor of PKA, reduced the IL-1 and IL-6 levels by 29 and 27%, respectively. N-(2-guanidinoethyl)-5-isoquinolinesulfonamide 0-6 interleukin 6 Homo sapiens 50-54 8798409-1 1996 We reported recently that angiotensin II (AII) and phorbol 12-myristate 13-acetate (PMA) transiently inhibit interleukin 6 (IL-6)-stimulated tyrosine phosphorylation of signal transducers and activators of transcription 3 (Stat3) and subsequent formation of sis-inducing factor-A (SIF-A). Tyrosine 141-149 interleukin 6 Homo sapiens 124-128 8798409-1 1996 We reported recently that angiotensin II (AII) and phorbol 12-myristate 13-acetate (PMA) transiently inhibit interleukin 6 (IL-6)-stimulated tyrosine phosphorylation of signal transducers and activators of transcription 3 (Stat3) and subsequent formation of sis-inducing factor-A (SIF-A). Tetradecanoylphorbol Acetate 51-82 interleukin 6 Homo sapiens 109-122 8798409-9 1996 Treatment of cells with PD98059, a specific inhibitor of MAPKK1, attenuated the inhibitory effects of AII and PMA on IL-6-induced Stat3 tyrosine phosphorylation and SIF-A formation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 24-31 interleukin 6 Homo sapiens 117-121 8798409-1 1996 We reported recently that angiotensin II (AII) and phorbol 12-myristate 13-acetate (PMA) transiently inhibit interleukin 6 (IL-6)-stimulated tyrosine phosphorylation of signal transducers and activators of transcription 3 (Stat3) and subsequent formation of sis-inducing factor-A (SIF-A). Tetradecanoylphorbol Acetate 51-82 interleukin 6 Homo sapiens 124-128 8798409-1 1996 We reported recently that angiotensin II (AII) and phorbol 12-myristate 13-acetate (PMA) transiently inhibit interleukin 6 (IL-6)-stimulated tyrosine phosphorylation of signal transducers and activators of transcription 3 (Stat3) and subsequent formation of sis-inducing factor-A (SIF-A). Tetradecanoylphorbol Acetate 84-87 interleukin 6 Homo sapiens 109-122 8798409-9 1996 Treatment of cells with PD98059, a specific inhibitor of MAPKK1, attenuated the inhibitory effects of AII and PMA on IL-6-induced Stat3 tyrosine phosphorylation and SIF-A formation. Tyrosine 136-144 interleukin 6 Homo sapiens 117-121 8798409-1 1996 We reported recently that angiotensin II (AII) and phorbol 12-myristate 13-acetate (PMA) transiently inhibit interleukin 6 (IL-6)-stimulated tyrosine phosphorylation of signal transducers and activators of transcription 3 (Stat3) and subsequent formation of sis-inducing factor-A (SIF-A). Tetradecanoylphorbol Acetate 84-87 interleukin 6 Homo sapiens 124-128 8784206-2 1996 We have previously shown that a single-disulfide variant of human IL-6, lacking 22 N-terminal amino acids and the disulfide bond connecting Cys-45 and Cys-51 in the 185-residue chain of the wild-type protein, fully retains the conformational, stability, and functional properties of the full-length human IL-6 [Breton et al. Disulfides 39-48 interleukin 6 Homo sapiens 66-70 8805670-7 1996 IL-13 pretreatment of monocytes significantly diminished (p = 0.005) the suppressive effects of hydrocortisone on LPS-induced IL-6 production. Hydrocortisone 96-110 interleukin 6 Homo sapiens 126-130 8784206-2 1996 We have previously shown that a single-disulfide variant of human IL-6, lacking 22 N-terminal amino acids and the disulfide bond connecting Cys-45 and Cys-51 in the 185-residue chain of the wild-type protein, fully retains the conformational, stability, and functional properties of the full-length human IL-6 [Breton et al. Disulfides 114-123 interleukin 6 Homo sapiens 66-70 8790359-5 1996 The kinetics and requirement for new RNA and protein synthesis for inhibition of interleukin 6 by ionomycin and GM-CSF differed, but both agents increased the association of Jak1 with protein tyrosine phosphatase ID (SH2-containing phosphatase 2). Ionomycin 98-107 interleukin 6 Homo sapiens 81-94 8784206-2 1996 We have previously shown that a single-disulfide variant of human IL-6, lacking 22 N-terminal amino acids and the disulfide bond connecting Cys-45 and Cys-51 in the 185-residue chain of the wild-type protein, fully retains the conformational, stability, and functional properties of the full-length human IL-6 [Breton et al. Cysteine 140-143 interleukin 6 Homo sapiens 66-70 8784206-2 1996 We have previously shown that a single-disulfide variant of human IL-6, lacking 22 N-terminal amino acids and the disulfide bond connecting Cys-45 and Cys-51 in the 185-residue chain of the wild-type protein, fully retains the conformational, stability, and functional properties of the full-length human IL-6 [Breton et al. Cysteine 151-154 interleukin 6 Homo sapiens 66-70 8843757-4 1996 There was no difference in either the epinephrine or norepinephrine peaks among the three treatments, but the net area under the curve for IL-6 was smaller after hydrocortisone or dexamethasone than after placebo and smaller after dexamethasone than after hydrocortisone. Hydrocortisone 162-176 interleukin 6 Homo sapiens 139-143 8843757-4 1996 There was no difference in either the epinephrine or norepinephrine peaks among the three treatments, but the net area under the curve for IL-6 was smaller after hydrocortisone or dexamethasone than after placebo and smaller after dexamethasone than after hydrocortisone. Dexamethasone 180-193 interleukin 6 Homo sapiens 139-143 8843757-4 1996 There was no difference in either the epinephrine or norepinephrine peaks among the three treatments, but the net area under the curve for IL-6 was smaller after hydrocortisone or dexamethasone than after placebo and smaller after dexamethasone than after hydrocortisone. Dexamethasone 231-244 interleukin 6 Homo sapiens 139-143 8843757-4 1996 There was no difference in either the epinephrine or norepinephrine peaks among the three treatments, but the net area under the curve for IL-6 was smaller after hydrocortisone or dexamethasone than after placebo and smaller after dexamethasone than after hydrocortisone. Hydrocortisone 256-270 interleukin 6 Homo sapiens 139-143 8843757-5 1996 A positive correlation was observed between peak plasma epinephrine or norepinephrine and IL-6 levels at 15 min. Norepinephrine 71-85 interleukin 6 Homo sapiens 90-94 8884530-4 1996 FK506 and CsA inhibit keratinocyte proliferation induced by EGF, TGF-alpha or IL-6. Cyclosporine 10-13 interleukin 6 Homo sapiens 78-82 8932980-2 1996 ET-18-OCH3 significantly increased the release of IL-6, giving the greatest effect at the dose of 2 micrograms/ml. edelfosine 0-10 interleukin 6 Homo sapiens 50-54 8797679-3 1996 Using cultured KS cells that retain the KSHV sequences, diverse signals, including tumor necrosis factor alpha, interleukin (IL) 1 beta, polyinosinic acid/polycytidylic acid and lipopolysaccharide, induced the expression of the cytokine IL-6 and cellular adhesion molecules involved in leukocyte recruitment, including vascular adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1). Poly I 137-154 interleukin 6 Homo sapiens 237-241 8811066-15 1996 EBV-transformed B-cell clones incubated with RA for 6 days produced a 20- to 45-fold increase in IL-6. Tretinoin 45-47 interleukin 6 Homo sapiens 97-101 8914271-1 1996 Essentially complete backbone and side-chain 1H, 15N and 13C resonance assignments for the 185-amino-acid cytokine interleukin-6 (IL-6) are presented. Hydrogen 45-47 interleukin 6 Homo sapiens 115-128 8914271-1 1996 Essentially complete backbone and side-chain 1H, 15N and 13C resonance assignments for the 185-amino-acid cytokine interleukin-6 (IL-6) are presented. Hydrogen 45-47 interleukin 6 Homo sapiens 130-134 8884530-6 1996 These findings might indicate that the effects of FK506 and CsA on proliferation of cultured normal human keratinocytes are probably related to direct effects on growth regulation of keratinocytes via EGF, TGF-alpha or IL-6 stimulation. Cyclosporine 60-63 interleukin 6 Homo sapiens 219-223 9816316-2 1996 Among the resistant melanoma cell lines, 50-60% constitutively produced IL-6, which appeared to function as a growth stimulator in vitro, based on the growth-suppressive effects of antisense oligonucleotides to the IL-6 gene. Oligonucleotides 191-207 interleukin 6 Homo sapiens 72-76 8761470-0 1996 Dual regulation of heat-shock transcription factor (HSF) activation and DNA-binding activity by H2O2: role of thioredoxin. Hydrogen Peroxide 96-100 interleukin 6 Homo sapiens 19-50 8761470-0 1996 Dual regulation of heat-shock transcription factor (HSF) activation and DNA-binding activity by H2O2: role of thioredoxin. Hydrogen Peroxide 96-100 interleukin 6 Homo sapiens 52-55 8761470-6 1996 We found that oxidizing agents, such as H2O2 and diamide, as well as alkylating agents, such as iodoacetic acid, abolished, in vitro, the HSF-DNA-binding activity induced by HS in vivo. Hydrogen Peroxide 40-44 interleukin 6 Homo sapiens 138-141 8761470-9 1996 Thus, H2O2 exerts dual effects on the activation and the DNA-binding activity of HSF: on the one hand, H2O2 favours the nuclear translocation of HSF, while on the other, it alters HSF-DNA-binding activity, most likely by oxidizing critical cysteine residues within the DNA-binding domain. Hydrogen Peroxide 6-10 interleukin 6 Homo sapiens 81-84 8761470-9 1996 Thus, H2O2 exerts dual effects on the activation and the DNA-binding activity of HSF: on the one hand, H2O2 favours the nuclear translocation of HSF, while on the other, it alters HSF-DNA-binding activity, most likely by oxidizing critical cysteine residues within the DNA-binding domain. Hydrogen Peroxide 6-10 interleukin 6 Homo sapiens 145-148 8761470-9 1996 Thus, H2O2 exerts dual effects on the activation and the DNA-binding activity of HSF: on the one hand, H2O2 favours the nuclear translocation of HSF, while on the other, it alters HSF-DNA-binding activity, most likely by oxidizing critical cysteine residues within the DNA-binding domain. Hydrogen Peroxide 6-10 interleukin 6 Homo sapiens 145-148 8761470-9 1996 Thus, H2O2 exerts dual effects on the activation and the DNA-binding activity of HSF: on the one hand, H2O2 favours the nuclear translocation of HSF, while on the other, it alters HSF-DNA-binding activity, most likely by oxidizing critical cysteine residues within the DNA-binding domain. Hydrogen Peroxide 103-107 interleukin 6 Homo sapiens 81-84 8761470-9 1996 Thus, H2O2 exerts dual effects on the activation and the DNA-binding activity of HSF: on the one hand, H2O2 favours the nuclear translocation of HSF, while on the other, it alters HSF-DNA-binding activity, most likely by oxidizing critical cysteine residues within the DNA-binding domain. Hydrogen Peroxide 103-107 interleukin 6 Homo sapiens 145-148 8761470-9 1996 Thus, H2O2 exerts dual effects on the activation and the DNA-binding activity of HSF: on the one hand, H2O2 favours the nuclear translocation of HSF, while on the other, it alters HSF-DNA-binding activity, most likely by oxidizing critical cysteine residues within the DNA-binding domain. Hydrogen Peroxide 103-107 interleukin 6 Homo sapiens 145-148 8761470-9 1996 Thus, H2O2 exerts dual effects on the activation and the DNA-binding activity of HSF: on the one hand, H2O2 favours the nuclear translocation of HSF, while on the other, it alters HSF-DNA-binding activity, most likely by oxidizing critical cysteine residues within the DNA-binding domain. Cysteine 240-248 interleukin 6 Homo sapiens 81-84 8761470-9 1996 Thus, H2O2 exerts dual effects on the activation and the DNA-binding activity of HSF: on the one hand, H2O2 favours the nuclear translocation of HSF, while on the other, it alters HSF-DNA-binding activity, most likely by oxidizing critical cysteine residues within the DNA-binding domain. Cysteine 240-248 interleukin 6 Homo sapiens 145-148 8761470-9 1996 Thus, H2O2 exerts dual effects on the activation and the DNA-binding activity of HSF: on the one hand, H2O2 favours the nuclear translocation of HSF, while on the other, it alters HSF-DNA-binding activity, most likely by oxidizing critical cysteine residues within the DNA-binding domain. Cysteine 240-248 interleukin 6 Homo sapiens 145-148 8761470-10 1996 HSF thus belongs to the group of ROS-modulated transcription factors. Reactive Oxygen Species 33-36 interleukin 6 Homo sapiens 0-3 8761470-11 1996 We propose that the time required for TRX induction, which may restore the DNA-binding activity of oxidized HSF, provides an explanation for the delay in heat-shock protein synthesis upon exposure of cells to ROS. Reactive Oxygen Species 209-212 interleukin 6 Homo sapiens 108-111 8702454-5 1996 Serum levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF alpha), and IL-1 beta normalized within 7 days after the first administration of tretinoin, transiently increased at the time of radiotherapy, increased again after withdrawal of the tretinoin, and decreased again after its reintroduction. Tretinoin 152-161 interleukin 6 Homo sapiens 16-29 8702454-7 1996 This study documents in vivo the ability of all-trans-retinoic acid to down-regulate the release of IL-6, IL-1 beta, and TNF alpha, and illustrates its potential as a therapeutic agent in conditions associated with chronic overproduction of proinflammatory cytokines. Tretinoin 44-67 interleukin 6 Homo sapiens 100-104 8803383-3 1996 Palliative steroid therapy with 20 mg/day of prednisolone resulted in the decline of serum IL-6 level and, simultaneously, improved anorexia and oral intake. Steroids 11-18 interleukin 6 Homo sapiens 91-95 8803383-4 1996 Although there was no weight gain or improvement in hypoalbuminemia, these results suggest that steroids may suppress the abnormal production of IL-6 in cancer patients and that this action affects symptoms. Steroids 96-104 interleukin 6 Homo sapiens 145-149 8803383-5 1996 Further study is warranted to clarify the role of IL-6 in tumor-related symptoms and the effect of steroid therapy in relation to IL-6 production in cancer patients. Steroids 99-106 interleukin 6 Homo sapiens 130-134 8751470-4 1996 The increased level of IL-6 in this patient decreased to normal within 3 weeks of CsA administration and the patient became symptom-free. Cyclosporine 82-85 interleukin 6 Homo sapiens 23-27 8751470-7 1996 IL-6 production by LNMC was stimulated by IL-2 but inhibited by CsA. Cyclosporine 64-67 interleukin 6 Homo sapiens 0-4 8757381-10 1996 The interleukin-6 levels increased gradually after skin incision until the sixth hour and were significantly lower (p < 0.05) in the ibuprofen group. Ibuprofen 136-145 interleukin 6 Homo sapiens 4-17 8894439-5 1996 In contrast, dexamethasone downregulated IL-6 production by microglial cells and PBMC. Dexamethasone 13-26 interleukin 6 Homo sapiens 41-45 8751725-2 1996 As these patients have often elevated interleukin-6 (IL-6) and abnormally low cystine levels, we have now determined the intracellular levels of glutathione and other cysteine derivatives in the liver and muscle tissue of IL-6-treated or tumor-bearing C57BL/6 mice. Glutathione 145-156 interleukin 6 Homo sapiens 222-226 8751725-2 1996 As these patients have often elevated interleukin-6 (IL-6) and abnormally low cystine levels, we have now determined the intracellular levels of glutathione and other cysteine derivatives in the liver and muscle tissue of IL-6-treated or tumor-bearing C57BL/6 mice. Cysteine 167-175 interleukin 6 Homo sapiens 222-226 8768854-7 1996 Exacerbation of thyrotoxicosis with increased serum IL-6 values, observed in 4 patients while tapering steroid, was promptly corrected by increasing it. Steroids 103-110 interleukin 6 Homo sapiens 52-56 8880223-12 1996 Citalopram was equality as potent as imipramine and clomipramine in inhibiting IL-6 release after long-term exposure of monocytes to LPS. Imipramine 37-47 interleukin 6 Homo sapiens 79-83 8880223-12 1996 Citalopram was equality as potent as imipramine and clomipramine in inhibiting IL-6 release after long-term exposure of monocytes to LPS. Clomipramine 52-64 interleukin 6 Homo sapiens 79-83 8753710-0 1996 Increased levels of tumor necrosis factor-alpha and interleukin-6 protein and messenger RNA in human peripheral blood monocytes due to titanium particles. Titanium 135-143 interleukin 6 Homo sapiens 52-65 8753710-4 1996 There were consistent dose-dependent increases in the production of TNF-alpha (tumor necrosis factor-alpha) and IL-6 (interleukin-6) protein, with the greatest stimulation generally observed with a concentration of 6 x 10(5) to 6 x 10(6) particles of titanium per milliliter. Titanium 251-259 interleukin 6 Homo sapiens 112-116 8753710-4 1996 There were consistent dose-dependent increases in the production of TNF-alpha (tumor necrosis factor-alpha) and IL-6 (interleukin-6) protein, with the greatest stimulation generally observed with a concentration of 6 x 10(5) to 6 x 10(6) particles of titanium per milliliter. Titanium 251-259 interleukin 6 Homo sapiens 118-131 8753710-10 1996 After stimulation with titanium particles, the level of TNF-alpha mRNA was increased as much as fivefold and the level of IL-6 mRNA, as much as twelvefold. Titanium 23-31 interleukin 6 Homo sapiens 122-126 8760789-9 1996 These results indicate that histamine enhanced IgE and IgG4 production by increasing endogenous IL-6 and IL-10 production via H1 and H3 receptors, respectively. Histamine 28-37 interleukin 6 Homo sapiens 96-100 8877726-7 1996 Furthermore, some IL-6 variants with lysine 54 replacements could be used to construct muteins that retained receptor binding but failed to activate gp130. Lysine 37-43 interleukin 6 Homo sapiens 18-22 8760789-4 1996 In contrast, in cultures with IL-13 plus anti-CD58 mAb, histamine-induced enhancement was blocked by dimaprit (H1 receptor antagonist), and was inhibited by anti-IL-6 mAb. Histamine 56-65 interleukin 6 Homo sapiens 162-166 8760789-5 1996 Histamine also enhanced IgE and IgG4 production by in vivo-generated sIgE+ and sIgG4+ B cells, respectively, from atopic patients; enhancement was blocked by dimaprit and thioperamide, and was inhibited by anti-IL-6 mAb and anti-IL-10 Ab. Histamine 0-9 interleukin 6 Homo sapiens 211-215 8760789-7 1996 Histamine increased IL-10 and IL-6 production without affecting IL-10 and IL-6 receptor expression, in cultures with IL-4 plus anti-CD58 mAb and with IL-13 plus anti-CD58 mAb, respectively, which was blocked by thioperamide and dimaprit, respectively. Histamine 0-9 interleukin 6 Homo sapiens 30-34 8795300-1 1996 BACKGROUND: Serum interleukin-6 (IL-6) concentrations are frequently elevated in inflammatory thyroid diseases, such as subacute thyroiditis and amiodarone induced thyroiditis. Amiodarone 145-155 interleukin 6 Homo sapiens 18-31 8795300-1 1996 BACKGROUND: Serum interleukin-6 (IL-6) concentrations are frequently elevated in inflammatory thyroid diseases, such as subacute thyroiditis and amiodarone induced thyroiditis. Amiodarone 145-155 interleukin 6 Homo sapiens 33-37 8809410-9 1996 The examination of tyrosine phosphorylation of gp130 (as an early event in IL-6 signal transduction) revealed that gp130 could be phosphorylated in all cell lines after stimulation with IL-6 and/or IL-6 + sIL-6R. Tyrosine 19-27 interleukin 6 Homo sapiens 75-79 8678641-7 1996 Interleukin-6 correlated with duration of extracorporeal circulation, dose of norepinephrine and epinephrine support, pulmonary capillary wedge pressure, mean pulmonary arterial pressure, right atrial pressure, heart rate, cardiac index, and inversely with systemic vascular resistance. Norepinephrine 78-92 interleukin 6 Homo sapiens 0-13 8813652-5 1996 Active IL-6, but not IL-1 and TNF, is released from the gastric mucosa during acute mucosal damage by 2 M NaCl and acid back diffusion. Sodium Chloride 106-110 interleukin 6 Homo sapiens 7-11 8666148-4 1996 Both IL-6 and TNF-alpha mRNA levels and immunoreactivity were significantly increased by treatment with 33 mmol/l glucose compared with treatment with 11 mmol/l glucose or 11 mmol/l glucose with 22 mmol/l mannitol. Glucose 114-121 interleukin 6 Homo sapiens 5-9 8666148-4 1996 Both IL-6 and TNF-alpha mRNA levels and immunoreactivity were significantly increased by treatment with 33 mmol/l glucose compared with treatment with 11 mmol/l glucose or 11 mmol/l glucose with 22 mmol/l mannitol. Glucose 161-168 interleukin 6 Homo sapiens 5-9 8666148-4 1996 Both IL-6 and TNF-alpha mRNA levels and immunoreactivity were significantly increased by treatment with 33 mmol/l glucose compared with treatment with 11 mmol/l glucose or 11 mmol/l glucose with 22 mmol/l mannitol. Glucose 161-168 interleukin 6 Homo sapiens 5-9 8666148-5 1996 In addition, preincubation of the cells with an anti-TNF monoclonal antibody (mAb) blocked the stimulatory effect of 33 mmol/l glucose on IL-6 synthesis and secretion. Glucose 127-134 interleukin 6 Homo sapiens 138-142 8666148-0 1996 Glucose-dependent interleukin 6 and tumor necrosis factor production by human peripheral blood monocytes in vitro. Glucose 0-7 interleukin 6 Homo sapiens 18-31 8660820-4 1996 When human monocytes/macrophages stimulated with silica were treated with 0.1-10 microg/ml acanthoic acid, the production of IL-1 and TNF-alpha was inhibited up to 90%, but the production of interleukin-6 (IL-6) was not inhibited at all. acanthoic acid 91-105 interleukin 6 Homo sapiens 191-204 8690800-3 1996 IL-6 is known to stimulate osteoclast formation and in the IL-6 promoter, a cAMP responsive element has been identified. Cyclic AMP 76-80 interleukin 6 Homo sapiens 0-4 8690800-3 1996 IL-6 is known to stimulate osteoclast formation and in the IL-6 promoter, a cAMP responsive element has been identified. Cyclic AMP 76-80 interleukin 6 Homo sapiens 59-63 8690800-8 1996 Rp-8Br-cAMP significantly inhibited IL-6 production in the patient cells, while it had no effect on normal control. Cyclic AMP 7-11 interleukin 6 Homo sapiens 36-40 8690800-9 1996 The addition of dibutyryl cAMP significantly increased the synthesis of IL-6 in normal control cells. Cyclic AMP 26-30 interleukin 6 Homo sapiens 72-76 8690800-11 1996 These data suggest that IL-6 is, at least, one of the downstream effectors of cAMP and that the increased IL-6 synthesis has a pathogenic role in the bone lesions of MAS patients via increasing the number of osteoclasts. Cyclic AMP 78-82 interleukin 6 Homo sapiens 24-28 8693287-5 1996 Anti-oestrogens, tamoxifen and toremifene, stimulated overall cytokine production on a B-cell line (Ball), whereas on a T-cell line (Molt-4) tamoxifen stimulated IL-1 beta, IL-6 and IFN-gamma production and toremifene inhibited it. Tamoxifen 141-150 interleukin 6 Homo sapiens 173-177 8841895-0 1996 Prostaglandin E2 potentiates interleukin-1 beta induced interleukin-6 production by human gingival fibroblasts. Dinoprostone 0-16 interleukin 6 Homo sapiens 56-69 8841895-4 1996 Therefore, the purpose of this study was to determine if PGE2 induced by IL-1 beta could potentiate the IL-6 response by HGF. Dinoprostone 57-61 interleukin 6 Homo sapiens 104-108 8841895-7 1996 Interestingly, the combination of IL gamma beta and PGE2 induced a synergistic rise in IL-6 production by HGF. Dinoprostone 52-56 interleukin 6 Homo sapiens 87-91 8841895-10 1996 These results suggest the endogenous PGE2 induced by IL-1 beta plays an important regulatory role in IL 6 production by HGF. Dinoprostone 37-41 interleukin 6 Homo sapiens 101-105 8796788-1 1996 The objective of this study was to characterize interleukin-1, -6, and -8 (IL-1-, IL-6-, and IL-8)-induced prostacyclin (PGI2 as 6-keto PGF1 alpha) and prostaglandin E2 (PGE2) production in primary cultures of human myometrial cells. 6-keto pgf1 129-140 interleukin 6 Homo sapiens 82-86 8796788-1 1996 The objective of this study was to characterize interleukin-1, -6, and -8 (IL-1-, IL-6-, and IL-8)-induced prostacyclin (PGI2 as 6-keto PGF1 alpha) and prostaglandin E2 (PGE2) production in primary cultures of human myometrial cells. Dinoprostone 152-168 interleukin 6 Homo sapiens 82-86 8796788-1 1996 The objective of this study was to characterize interleukin-1, -6, and -8 (IL-1-, IL-6-, and IL-8)-induced prostacyclin (PGI2 as 6-keto PGF1 alpha) and prostaglandin E2 (PGE2) production in primary cultures of human myometrial cells. Dinoprostone 170-174 interleukin 6 Homo sapiens 82-86 8706672-0 1996 Participation of two Ser-Ser-Phe-Tyr repeats in interleukin-6 (IL-6)-binding sites of the human IL-6 receptor. Serine 21-24 interleukin 6 Homo sapiens 48-61 8706672-0 1996 Participation of two Ser-Ser-Phe-Tyr repeats in interleukin-6 (IL-6)-binding sites of the human IL-6 receptor. Serine 21-24 interleukin 6 Homo sapiens 63-67 8706672-0 1996 Participation of two Ser-Ser-Phe-Tyr repeats in interleukin-6 (IL-6)-binding sites of the human IL-6 receptor. Serine 21-24 interleukin 6 Homo sapiens 96-100 8706672-0 1996 Participation of two Ser-Ser-Phe-Tyr repeats in interleukin-6 (IL-6)-binding sites of the human IL-6 receptor. Serine 25-28 interleukin 6 Homo sapiens 48-61 8706672-0 1996 Participation of two Ser-Ser-Phe-Tyr repeats in interleukin-6 (IL-6)-binding sites of the human IL-6 receptor. Serine 25-28 interleukin 6 Homo sapiens 63-67 8660820-4 1996 When human monocytes/macrophages stimulated with silica were treated with 0.1-10 microg/ml acanthoic acid, the production of IL-1 and TNF-alpha was inhibited up to 90%, but the production of interleukin-6 (IL-6) was not inhibited at all. acanthoic acid 91-105 interleukin 6 Homo sapiens 206-210 8706672-0 1996 Participation of two Ser-Ser-Phe-Tyr repeats in interleukin-6 (IL-6)-binding sites of the human IL-6 receptor. Serine 25-28 interleukin 6 Homo sapiens 96-100 9035763-0 1996 [The effect of dexamethasone dose and cell population composition on in vitro production of tumor necrosis factor and interleukin-6 by mononuclear cells in peripheral blood of man]. Dexamethasone 15-28 interleukin 6 Homo sapiens 118-131 8652179-8 1996 IL-6 production was augmented by the addition of interleukin 1 alpha (IL-1 alpha) in a dose-dependent manner and suppressed by dexamethasone. Dexamethasone 127-140 interleukin 6 Homo sapiens 0-4 8639855-14 1996 Thus, while chronically high endogenous IL-6 levels do not appear to blunt epo production, they are probably responsible for the observed abnormalities in iron metabolism. Iron 155-159 interleukin 6 Homo sapiens 40-44 8635282-3 1996 Moreover, we evaluated the effect of IL-6 on the in vitro AFb proliferation in both diseases. afb 58-61 interleukin 6 Homo sapiens 37-41 8780895-7 1996 Upon incubation with differentiation inducers such as 12-O-tetradecanoylphorbol-13-acetate, lipopolysaccharide, a combination of interleukin (IL) 6 plus tumor necrosis factor (TNF) alpha, or IFN-gamma plus TNF-alpha, a pronounced increase in the amounts of Met mRNA and protein are seen in THP-1 cells. Tetradecanoylphorbol Acetate 54-90 interleukin 6 Homo sapiens 129-147 8635282-6 1996 Addition of anti-IL-6 MoAbs increased AFb proliferation capacity in SA, but suppressed it in DIF. afb 38-41 interleukin 6 Homo sapiens 17-21 8676080-4 1996 Although devoid of direct effects on cells of hematopoietic origin, hIL-17 and the product of its viral counterpart, ORF13, stimulate epithelial, endothelial, and fibroblastic cells to secrete cytokines such as IL-6, IL-8, and granulocyte-colony-stimulating factor, as well as prostaglandin E2. Dinoprostone 277-293 interleukin 6 Homo sapiens 211-215 8647208-1 1996 We have used two experimental models of immune complexes to study the secretion of interleukin (IL)-10, IL-6 and their connection with the immune complex-induced synthesis of prostaglandin (PG) E2 by human monocytes in vitro. Dinoprostone 175-196 interleukin 6 Homo sapiens 104-108 8647208-4 1996 PGE2 could augment the immune complex-induced IL-6 and IL-10 secretion, but alone, did not induce cytokine secretion. Dinoprostone 0-4 interleukin 6 Homo sapiens 46-50 8811326-0 1996 Elevated glucose levels stimulate transforming growth factor-beta 1 (TGF-beta 1), suppress interleukin IL-2, IL-6 and IL-10 production and DNA synthesis in peripheral blood mononuclear cells. Glucose 9-16 interleukin 6 Homo sapiens 109-113 8811326-5 1996 Exposure to elevated glucose levels caused a significant and dose-dependent increase in the production of latent TGF-beta 1 by (PWM)-stimulated PBMC at 24 and 48 h. Production of the cytokines IL-2, IL-6 and IL-10 was suppressed by elevated glucose concentration dose- and time-dependently. Glucose 21-28 interleukin 6 Homo sapiens 199-203 8811326-6 1996 In contrast to the time-dependent decreased effect of glucose-induced TGF-beta 1 production the effects of elevated glucose levels on IL-2, IL-6 and IL-10 production increased with time indicating that TGF-beta 1 production is preceding the reduced IL production. Glucose 116-123 interleukin 6 Homo sapiens 140-144 8811326-8 1996 Our results indicate that high glucose-induced TGF-beta 1 production may suppress immune response by inhibiting the endogenous production of IL-2, IL-6 and IL-10. Glucose 31-38 interleukin 6 Homo sapiens 147-151 8964868-0 1996 Acute glucocorticoid deficiency is associated with plasma elevations of interleukin-6: does the latter participate in the symptomatology of the steroid withdrawal syndrome and adrenal insufficiency? Steroids 144-151 interleukin 6 Homo sapiens 72-85 8964868-11 1996 The increased IL-6 production that occurs when cortisol levels fall might explain the symptomatology of acute glucocorticoid deficiency. Hydrocortisone 47-55 interleukin 6 Homo sapiens 14-18 8973087-9 1996 CONCLUSIONS: Initial elevation of IL-6 concentration might induce stress hormones such as norepinephrine and glucagon, but not insulin after surgical trauma. Norepinephrine 90-104 interleukin 6 Homo sapiens 34-38 8973087-6 1996 Initial elevation and steady decline of IL-6 concentrations were seen after surgical injury, and this response related significantly to post-operative norepinephrine and glucagon levels throughout the study period, and to insulin levels only at the end of surgery. Norepinephrine 151-165 interleukin 6 Homo sapiens 40-44 8648229-4 1996 CSF glucose levels correlated highly with levels of IL-10, sTNFR-55, and sTNFR-75 and weakly with TNF-alpha and IL-6. Glucose 4-11 interleukin 6 Homo sapiens 112-116 8776731-3 1996 As previous reports have shown that the human IL-6 promoter is inhibited by estradiol, we investigated the mechanism of estradiol (E2)-mediated IL-6 inhibition in human cells. Estradiol 76-85 interleukin 6 Homo sapiens 46-50 8724532-4 1996 We studied the interaction of TNF and IL-6 in the regulation of DNA synthesis (3H-TdR uptake), cytokine release and cell survival in CLL cells in vitro. Tritium 79-81 interleukin 6 Homo sapiens 38-42 8724532-9 1996 IL-6 (100 U/ml or greater) increased spontaneous DNA synthesis (3H-TdR uptake) but, in the presence of high concentrations of TNF-alpha, inhibited TNF induced DNA synthesis in a dose dependent manner. Tritium 64-66 interleukin 6 Homo sapiens 0-4 8776731-3 1996 As previous reports have shown that the human IL-6 promoter is inhibited by estradiol, we investigated the mechanism of estradiol (E2)-mediated IL-6 inhibition in human cells. Estradiol 120-129 interleukin 6 Homo sapiens 144-148 8662795-9 1996 271, 12991-12998), we demonstrated that two tyrosine motifs within the cytoplasmic part of the interleukin 6 signal transducer gp130 specifically mediate APRF activation while two others can recruit both APRF and Stat1. Tyrosine 44-52 interleukin 6 Homo sapiens 95-108 8662591-7 1996 We have analyzed by mutational studies and by phosphopeptide competition assays which of the tyrosine modules of the IL-6 signal transducer gp130 are capable of recruiting either APRF or STAT1. Tyrosine 93-101 interleukin 6 Homo sapiens 117-121 8725624-5 1996 In our analysis of IL-6 gene regulation employing reporter gene and electrophoretic mobility shift assays, we have found that bacterial lipopolysaccharide and cyclic adenosine monophosphate synergistically induce IL-6 expression in macrophages through at least four transcription factors, including AP-1, cAMP-responsive element-binding protein (CREB), NF-IL6, and NF-kappa B. Cyclic AMP 159-189 interleukin 6 Homo sapiens 19-23 8651752-7 1996 Fluorescent-activated cell sorter (FACS) analysis was used to study the effects of dexamethasone on IL-6 receptor number in the well-differentiated human hepatoma HepG2. Dexamethasone 83-96 interleukin 6 Homo sapiens 100-104 8651752-8 1996 RESULTS: Both IL-6 and TNF-alpha exerted a small stimulatory effect on alanine and glutamine transport. Alanine 71-78 interleukin 6 Homo sapiens 14-18 8631918-0 1996 Stimulation by parathyroid hormone of interleukin-6 and leukemia inhibitory factor expression in osteoblasts is an immediate-early gene response induced by cAMP signal transduction. Cyclic AMP 156-160 interleukin 6 Homo sapiens 38-51 8631918-5 1996 Moreover, activation of cAMP signal transduction by parathyroid hormone and parathyroid hormone-related protein is necessary and sufficient to induce both interleukin-6 and leukemia inhibitory factor. Cyclic AMP 24-28 interleukin 6 Homo sapiens 155-168 8631918-6 1996 In addition, cAMP analogues as well as vasoactive intestinal peptide and isoproterenol, two neuropeptides that stimulate bone resorption by activating cAMP signal transduction in osteoblasts, also induce interleukin-6 and leukemia inhibitory factor in these cells. Cyclic AMP 13-17 interleukin 6 Homo sapiens 204-217 8631918-6 1996 In addition, cAMP analogues as well as vasoactive intestinal peptide and isoproterenol, two neuropeptides that stimulate bone resorption by activating cAMP signal transduction in osteoblasts, also induce interleukin-6 and leukemia inhibitory factor in these cells. Cyclic AMP 151-155 interleukin 6 Homo sapiens 204-217 8651752-11 1996 Fluorescent-activated cell sorter analysis demonstrated that dexamethasone induced a threefold increase in the expression of high-affinity IL-6 receptors. Dexamethasone 61-74 interleukin 6 Homo sapiens 139-143 8651752-13 1996 Dexamethasone exerts a permissive effect on cytokine-mediated increases in transport by increasing IL-6 receptor expression on the cell surface. Dexamethasone 0-13 interleukin 6 Homo sapiens 99-103 8725624-5 1996 In our analysis of IL-6 gene regulation employing reporter gene and electrophoretic mobility shift assays, we have found that bacterial lipopolysaccharide and cyclic adenosine monophosphate synergistically induce IL-6 expression in macrophages through at least four transcription factors, including AP-1, cAMP-responsive element-binding protein (CREB), NF-IL6, and NF-kappa B. Cyclic AMP 159-189 interleukin 6 Homo sapiens 213-217 8724299-5 1996 The addition of PGE2 to cultures stimulated with IL-1 alpha and indomethacin resulted increases in IL-6 mRNA and protein expression while causing a concomitant reduction in GMCSF protein and mRNA expression. Dinoprostone 16-20 interleukin 6 Homo sapiens 99-103 8933213-0 1996 Inhibition by dexamethasone of the lipopolysaccharide-induced increase in IL-6 mRNA abundance and IL-6 production in human polymorphonuclear leukocytes. Dexamethasone 14-27 interleukin 6 Homo sapiens 74-78 8933213-0 1996 Inhibition by dexamethasone of the lipopolysaccharide-induced increase in IL-6 mRNA abundance and IL-6 production in human polymorphonuclear leukocytes. Dexamethasone 14-27 interleukin 6 Homo sapiens 98-102 8933213-6 1996 These results indicate that PMNs are an important source of IL-6 in acute inflammatory reactions, and that the anti-inflammatory actions of dexamethasone is attributable in part to inhibition of IL-6 production by these cells. Dexamethasone 140-153 interleukin 6 Homo sapiens 195-199 8676260-7 1996 At 6 and 48 hours, the highest concentration of titanium alloy particles (0.189% [vol/vol]) resulted in 7-fold and 16-fold increases in interleukin-6 release, respectively, when compared with negative controls. Titanium 48-62 interleukin 6 Homo sapiens 136-149 8676260-9 1996 The pattern of prostaglandin E2 release by fibroblasts mirrored the pattern of interleukin-6 release. Dinoprostone 15-31 interleukin 6 Homo sapiens 79-92 8731145-5 1996 The HA/TCP particles dried at 110 degrees C were the most biologically active, stimulating significant release of interleukin 1 beta (IL-1 beta), IL-6, tumor necrosis factor alpha, and prostaglandin E2 (PGE2), products implicated as important mediators of inflammation in diverse pathologic conditions. N-(3,4,5-trichlorophenyl)succinimide 7-10 interleukin 6 Homo sapiens 146-150 8734361-8 1996 Polyclonal rabbit anti-IL-6 antibodies were used to block the augmenting effects of RA on Ig synthesis of adenoidal B cells. Tretinoin 84-86 interleukin 6 Homo sapiens 23-27 8734361-9 1996 RA-induced augmentation in IgG and IgA synthesis was blocked 58 and 29%, respectively, by anti-IL-6 antibodies. Tretinoin 0-2 interleukin 6 Homo sapiens 95-99 8734361-10 1996 These studies suggest that the enhancing effects of RA on Ig synthesis are mediated, at least in part, by the autocrine or paracrine effects of IL-6 on B-cell differentiation. Tretinoin 52-54 interleukin 6 Homo sapiens 144-148 8724299-0 1996 Prostaglandin E2 enhances interleukin 8 (IL-8) and IL-6 but inhibits GMCSF production by IL-1 stimulated human synovial fibroblasts in vitro. Dinoprostone 0-16 interleukin 6 Homo sapiens 51-55 9172802-3 1996 Peripheral blood mononuclear cells (PBMC), following infection with EBV and CsA treatment, demonstrated increased IL-6 activity in the culture supernatant. Cyclosporine 76-79 interleukin 6 Homo sapiens 114-118 8731113-8 1996 HPMC synthesis of IL-6 was unaffected by 15 or 30 minutes pre-exposure to BIC 20 or BIC 30, in contrast pre-exposure to CAPD 2 or CAPD 3 for 15 or 30 minutes resulted in a significant reduction in stimulated IL-6 synthesis (24.5 +/- 3.01 and 32.3 +/- 5.0 vs. 43.9 +/- 10 pg/microgram cell protein in M199, N = 6; P = 0.02). hydroxypropylmethylcellulose-lactose matrix 0-4 interleukin 6 Homo sapiens 18-22 8816327-6 1996 In addition, the HSP and PGE2 treatment used inhibited the production of the Th1 cytokines IL-2 and IFNg but had a differential modulatory effect on Th2 cytokine production, namely enhancing the production of IL-6 whilst simultaneously impairing the synthesis of IL-4 and IL-10. Dinoprostone 25-29 interleukin 6 Homo sapiens 209-213 9172802-6 1996 Expression of IL-6 in T cells appeared to be due mainly to CsA. Cyclosporine 59-62 interleukin 6 Homo sapiens 14-18 9172802-9 1996 IL-6, which was induced by CsA in PBMC, was also capable of inducing the lytic viral cycle in several EBV-immortalized cells. Cyclosporine 27-30 interleukin 6 Homo sapiens 0-4 9172802-11 1996 Thus CsA treatment, in promoting both increased numbers of lytic EBV B cells and expression of the EBV paracrine growth factor, IL-6, within the microenvironment of EBV B:T cell and EBV B:monocyte interactions, may lead to increased EBV B-cell immortalization and ultimately result in the promotion of B-cell lymphomas in immunosuppressed patients. Cyclosporine 5-8 interleukin 6 Homo sapiens 128-132 8623544-8 1996 Considering the role of IL-6 in inflammation, immune response, and its known association with increased levels of MyD116 and GADD 34 mRNAs (genes involved in the prevention of apoptotic death of cells), the present data may have relevance to HSV-1-mediated diseases as well as to the prevalence of HSV-1 in the host. gadd 125-129 interleukin 6 Homo sapiens 24-28 8881437-7 1996 This process is dependent upon an IL6-autocrine differentiation pathway which may be modulated by some drugs such as interferons or all trans retinoic acid. Tretinoin 142-155 interleukin 6 Homo sapiens 34-37 8726598-8 1996 Thus, the inhibitory effect of interleukin-6 may alter cyclosporine concentrations, which in turn may increase its adverse effects, such as nephrotoxicity. Cyclosporine 55-67 interleukin 6 Homo sapiens 31-44 8651611-0 1996 Effects of taxol on TNF-alpha and IL-6 production by human peripheral blood cells. Paclitaxel 11-16 interleukin 6 Homo sapiens 34-38 8632998-3 1996 In the case of IL-6 and LIF, which share a signal transducing receptor gp130, STAT3 is specifically tyrosine-phosphorylated and activated by stimulation with each cytokine in various cell types. Tyrosine 100-108 interleukin 6 Homo sapiens 15-19 8603813-6 1996 The molecular weight of human HSF was about 42 kDa as estimated by SDS-PAGE. Sodium Dodecyl Sulfate 67-70 interleukin 6 Homo sapiens 30-33 8730220-3 1996 Acute ethanol administration significantly increased plasma clearance rate for both cytokines (36% and 72%, for IL-6 and TNF-alpha, respectively), decreased the t1/2 alpha (30% and 11%, for IL-6 and TNF-alpha, respectively), abolished the slow (beta)-phase component for TNF-alpha, and increased t1/2 beta for IL-6 (31%). Ethanol 6-13 interleukin 6 Homo sapiens 190-194 8730220-8 1996 Data presented in this study demonstrate that: (1) acute alcohol consumption can alter the kinetic behavior of IL-6 and TNF-alpha in the bloodstream, mainly by accelerating their clearance which, in turn, may counteract the outcome of cytokine secretion and delivery to the blood; and (2) short exposure of liver to ethanol levels commonly seen in humans after binge drinking may alter its capacity to take up cytokines. Alcohols 57-64 interleukin 6 Homo sapiens 111-115 8730220-8 1996 Data presented in this study demonstrate that: (1) acute alcohol consumption can alter the kinetic behavior of IL-6 and TNF-alpha in the bloodstream, mainly by accelerating their clearance which, in turn, may counteract the outcome of cytokine secretion and delivery to the blood; and (2) short exposure of liver to ethanol levels commonly seen in humans after binge drinking may alter its capacity to take up cytokines. Ethanol 316-323 interleukin 6 Homo sapiens 111-115 8728019-3 1996 The synthetic glucocorticoid dexamethasone 1) inhibits the LPS-initiated vascular leak of plasma proteins into the airspace, 2) inhibits the LPS-initiated emigration of neutrophils and lymphocytes into the airspace in a dose-dependent fashion, and 3) inhibits LPS-initiated mRNA and/or bronchoalveolar lavage protein expression of cytokines (TNF, IL-1 and IL-6) and chemokines (MIP-1 alpha, MIP-2 and MCP-1). Dexamethasone 29-42 interleukin 6 Homo sapiens 356-360 8603522-0 1996 Retinoic acid modulates the in vivo and in vitro growth of IL-6 autocrine human myeloma cell lines via induction of apoptosis. Tretinoin 0-13 interleukin 6 Homo sapiens 59-63 8603522-7 1996 RA-mediated interruption of the IL-6 autocrine loop was associated with a decrease of bcl-2 oncoprotein expression and apoptosis of the myeloma cells which was RA concentration- and time-dependent. Tretinoin 0-2 interleukin 6 Homo sapiens 32-36 8603522-7 1996 RA-mediated interruption of the IL-6 autocrine loop was associated with a decrease of bcl-2 oncoprotein expression and apoptosis of the myeloma cells which was RA concentration- and time-dependent. Tretinoin 160-162 interleukin 6 Homo sapiens 32-36 8603522-11 1996 Our study indicate that long-term RA treatment interferes in vivo and in vitro with IL-6 autocrine growth of myeloma cell lines, leading to apoptosis. Tretinoin 34-36 interleukin 6 Homo sapiens 84-88 8708165-11 1996 CONCLUSIONS: This study demonstrates that patients with high post operative oxygen consumption after elective cardiac surgery have higher circulating levels of endotoxin, TNF and IL-6 and also have more symptoms of post-perfusion syndrome. Oxygen 76-82 interleukin 6 Homo sapiens 179-183 8689410-8 1996 The PMA- and ionomycin-induced increases in HSF were in a concentration-dependent manner with a maximal increase at 10(-6) mol/L of each drug. Ionomycin 13-22 interleukin 6 Homo sapiens 44-47 8627294-3 1996 Because in experimental animals ischemia increases both the levels of cytokines and the extracellular concentrations of adenosine in the brain, we hypothesized that these two phenomena may be functionally connected and that adenosine might increase IL-6 gene expression in the brain. Adenosine 224-233 interleukin 6 Homo sapiens 249-253 8621406-0 1996 A di-leucine motif and an upstream serine in the interleukin-6 (IL-6) signal transducer gp130 mediate ligand-induced endocytosis and down-regulation of the IL-6 receptor. Serine 35-41 interleukin 6 Homo sapiens 49-62 8726410-0 1996 Mechanisms of inhibition of IL-6-mediated immunoglobulin secretion by dexamethasone and suramin in human lymphoid and myeloma cell lines. Dexamethasone 70-83 interleukin 6 Homo sapiens 28-32 8726410-3 1996 Previous studies in our laboratory have shown that dexamethasone and suramin inhibit cell proliferation and IL-6-mediated immunoglobulin secretion in various lymphoblastoid and myeloma cell lines. Dexamethasone 51-64 interleukin 6 Homo sapiens 108-112 8726410-4 1996 In the present study, we present study, we present data to examine mechanisms by which dexamethasone and suramin inhibit IL-6-mediated immunoglobulin secretion in the lymphoid cell line SKW 6.4. Dexamethasone 87-100 interleukin 6 Homo sapiens 121-125 8726410-10 1996 An rtPCR analysis of IL-6 mRNA expression shows an abolished signal in response to dexamethasone or rIL-6 and/or dexamethasone. Dexamethasone 83-96 interleukin 6 Homo sapiens 21-25 8726410-10 1996 An rtPCR analysis of IL-6 mRNA expression shows an abolished signal in response to dexamethasone or rIL-6 and/or dexamethasone. Dexamethasone 113-126 interleukin 6 Homo sapiens 21-25 8623159-8 1996 IL-6 levels identified steroid and OKT3 resistance within 48 hr of antirejection therapy. Steroids 23-30 interleukin 6 Homo sapiens 0-4 8623159-9 1996 IL-6 levels elevated to 197 +/- 20 pg/ml among steroid-resistant patients and normalized to 20 +/- 5 pg/ml among responders. Steroids 47-54 interleukin 6 Homo sapiens 0-4 8626374-1 1996 Interleukin-6 (IL-6) induces tyrosine phosphorylation and activation of the latent transcription factor Stat3 in HepG2 cells. Tyrosine 29-37 interleukin 6 Homo sapiens 0-13 8626374-1 1996 Interleukin-6 (IL-6) induces tyrosine phosphorylation and activation of the latent transcription factor Stat3 in HepG2 cells. Tyrosine 29-37 interleukin 6 Homo sapiens 15-19 8626374-2 1996 Mutation of Stat3 tyrosine 705 to phenylalanine (Y705F) inhibits IL-6-induced tyrosine phosphorylation of this Stat3 mutant in transfected HepG2 cells. Tyrosine 18-26 interleukin 6 Homo sapiens 65-69 8631742-1 1996 An inhibitor of IL-6 binding to the human hepatoma line HepG2 and myeloma cell line U266 was identified in a saline extract of the marine sponge, Callyspongia sp. Sodium Chloride 109-115 interleukin 6 Homo sapiens 16-20 8640863-3 1996 Anti-IL-6 antibody and IL-6 antisense oligonucleotide suppressed the IL-6 stimulated myeloma cell proliferation, indicating that IL-6 induced the myeloma cell proliferation via an autocrine loop. Oligonucleotides 38-53 interleukin 6 Homo sapiens 23-27 8640863-3 1996 Anti-IL-6 antibody and IL-6 antisense oligonucleotide suppressed the IL-6 stimulated myeloma cell proliferation, indicating that IL-6 induced the myeloma cell proliferation via an autocrine loop. Oligonucleotides 38-53 interleukin 6 Homo sapiens 23-27 8640863-3 1996 Anti-IL-6 antibody and IL-6 antisense oligonucleotide suppressed the IL-6 stimulated myeloma cell proliferation, indicating that IL-6 induced the myeloma cell proliferation via an autocrine loop. Oligonucleotides 38-53 interleukin 6 Homo sapiens 23-27 8621406-0 1996 A di-leucine motif and an upstream serine in the interleukin-6 (IL-6) signal transducer gp130 mediate ligand-induced endocytosis and down-regulation of the IL-6 receptor. Serine 35-41 interleukin 6 Homo sapiens 64-68 8621406-0 1996 A di-leucine motif and an upstream serine in the interleukin-6 (IL-6) signal transducer gp130 mediate ligand-induced endocytosis and down-regulation of the IL-6 receptor. Serine 35-41 interleukin 6 Homo sapiens 156-160 8604711-3 1996 In addition, interleukin-1-beta-induced interleukin-6 production by human mesothelial cells was measured in the presence of concentrations of calcium increasing from 0 to 3.0 mmol/L. Calcium 142-149 interleukin 6 Homo sapiens 40-53 8600162-5 1996 Exposure of cells in growth medium to dexamethasone resulted in a decrease in the expression of LIF, IL-6, and IL-11. Dexamethasone 38-51 interleukin 6 Homo sapiens 101-105 8727677-4 1996 Moreover, BDP was able to reduce the inhibitory effect of a synthetic corticosteroid, dexamethasone on the biosynthesis of IL-6. Dexamethasone 86-99 interleukin 6 Homo sapiens 123-127 8727677-6 1996 The detailed analysis of the composition of the preparation suggested, that the major active component in the stimulation of IL-6 production is Zn, but for the complete effect other trace elements are also required. Zinc 144-146 interleukin 6 Homo sapiens 125-129 8630547-7 1996 Similarly, BAL-derived cells displayed significantly increased phorbol myristate acetate-stimulated release of superoxide anion (8.8 +/- 1.3 versus 4.5 +/- 0.7 nmol/5 x 10 5 cells/h; p<0.01) for the oldest versus youngest subject group, and mean BAL IL-6 concentrations were significantly elevated in the oldest age group (0.86 +/- 0.13 ng/ml) compared with the youngest age group (0.53 +/- 0.03 ng/ml; p<0.01). Tetradecanoylphorbol Acetate 63-88 interleukin 6 Homo sapiens 253-257 8630547-7 1996 Similarly, BAL-derived cells displayed significantly increased phorbol myristate acetate-stimulated release of superoxide anion (8.8 +/- 1.3 versus 4.5 +/- 0.7 nmol/5 x 10 5 cells/h; p<0.01) for the oldest versus youngest subject group, and mean BAL IL-6 concentrations were significantly elevated in the oldest age group (0.86 +/- 0.13 ng/ml) compared with the youngest age group (0.53 +/- 0.03 ng/ml; p<0.01). Superoxides 111-127 interleukin 6 Homo sapiens 253-257 8845178-0 1996 Alveolar macrophages autoregulate IL-1 and IL-6 production by endogenous nitric oxide. Nitric Oxide 73-85 interleukin 6 Homo sapiens 43-47 8845178-3 1996 Inhibition of the nitric oxide production by the L-arginine analogue N(G)-monomethyl-L-arginine (NMMA), resulted in an increase of IL-1(beta) and IL-6, whereas the TNF-alpha concentrations remained unchanged, suggesting specific inhibitory effects of nitric oxide on the LPS-stimulated cytokine production by alveolar macrophages. Nitric Oxide 18-30 interleukin 6 Homo sapiens 146-150 8845178-3 1996 Inhibition of the nitric oxide production by the L-arginine analogue N(G)-monomethyl-L-arginine (NMMA), resulted in an increase of IL-1(beta) and IL-6, whereas the TNF-alpha concentrations remained unchanged, suggesting specific inhibitory effects of nitric oxide on the LPS-stimulated cytokine production by alveolar macrophages. Arginine 49-59 interleukin 6 Homo sapiens 146-150 8845178-3 1996 Inhibition of the nitric oxide production by the L-arginine analogue N(G)-monomethyl-L-arginine (NMMA), resulted in an increase of IL-1(beta) and IL-6, whereas the TNF-alpha concentrations remained unchanged, suggesting specific inhibitory effects of nitric oxide on the LPS-stimulated cytokine production by alveolar macrophages. omega-N-Methylarginine 69-95 interleukin 6 Homo sapiens 146-150 8845178-3 1996 Inhibition of the nitric oxide production by the L-arginine analogue N(G)-monomethyl-L-arginine (NMMA), resulted in an increase of IL-1(beta) and IL-6, whereas the TNF-alpha concentrations remained unchanged, suggesting specific inhibitory effects of nitric oxide on the LPS-stimulated cytokine production by alveolar macrophages. omega-N-Methylarginine 97-101 interleukin 6 Homo sapiens 146-150 8845178-6 1996 The results indicate that nitric oxide can affect the LPS-induced IL-1beta and IL-6 secretion by alveolar macrophages in an autoregulatory way and are discussed in view of the important physiologic consequences this autoregulation by nitric acid oxide may have. Nitric Oxide 26-38 interleukin 6 Homo sapiens 79-83 8769856-4 1996 Introduction of antisense oligonucleotide to GRP78 into astrocytes prevented expression of the protein and suppressed H/R-induced astrocyte release of IL-6 by approximately 50%. Oligonucleotides 26-41 interleukin 6 Homo sapiens 151-155 8769856-5 1996 These data indicate that modulation of astrocyte properties during oxygen deprivation results, in part, from intracellular glucose depletion and subsequent expression of GRP78, which sustains generation of neuroprotective IL-6 under the stress of H/R. Oxygen 67-73 interleukin 6 Homo sapiens 222-226 8769856-5 1996 These data indicate that modulation of astrocyte properties during oxygen deprivation results, in part, from intracellular glucose depletion and subsequent expression of GRP78, which sustains generation of neuroprotective IL-6 under the stress of H/R. Glucose 123-130 interleukin 6 Homo sapiens 222-226 8650263-6 1996 Data from the IL2, IL6 and IFN systems indicate a major role for the tyrosine phosphorylated receptor/JAK complexes (rather than substrate specificity of the JAKs per se) in STAT selection. Tyrosine 69-77 interleukin 6 Homo sapiens 19-30 11859379-0 1996 Evidence of an Eicosanoid Contribution to IL-1 Induction of IL-6 in Human Articular Chondrocytes. Eicosanoids 15-25 interleukin 6 Homo sapiens 60-64 8779915-3 1996 Adenosine dose dependently inhibited the release of interleukin (IL)-6 and IL-8 by stimulated human umbilical vein endothelial cells (HUVEC). Adenosine 0-9 interleukin 6 Homo sapiens 52-70 11859379-3 1996 In this study we have utilized an alginate culture system in an effort to investigate a role for eicosanoids in IL-1 induction of IL-6 expression in human articular chondrocytes. Eicosanoids 97-108 interleukin 6 Homo sapiens 130-134 11859379-9 1996 Although IL-1-induced IL-6 expression was only affected when both prostaglandin and leukotriene biosynthesis were inhibited, elevated levels of PGE(2) but not leukotriene B(4), C(4), D(4), or E(4) were observed in the culture medium of IL-1-treated chondrocytes. Prostaglandins 66-79 interleukin 6 Homo sapiens 22-26 11859379-9 1996 Although IL-1-induced IL-6 expression was only affected when both prostaglandin and leukotriene biosynthesis were inhibited, elevated levels of PGE(2) but not leukotriene B(4), C(4), D(4), or E(4) were observed in the culture medium of IL-1-treated chondrocytes. Leukotrienes 84-95 interleukin 6 Homo sapiens 22-26 9816167-8 1996 ATRA also induced significant down-regulation of myeloma IL-6 receptors and inhibited IL-6 autosecretion by myeloma cells. Tretinoin 0-4 interleukin 6 Homo sapiens 57-61 11859379-10 1996 These findings may indicate that cyclo-oxygenase products such as PGE(2) normally contribute to IL-1 induction of IL-6 expression in chondrocytes, and under conditions when cyclo-oxygenase is inhibited, lipoxygenase products alternatively contribute to this response. Dinoprostone 66-72 interleukin 6 Homo sapiens 114-118 8625600-6 1996 The same drugs also reduced the levels of prostaglandin E2 and interleukin-6 release induced by phagocytosed titanium alloy particles. Titanium 109-123 interleukin 6 Homo sapiens 63-76 9816167-8 1996 ATRA also induced significant down-regulation of myeloma IL-6 receptors and inhibited IL-6 autosecretion by myeloma cells. Tretinoin 0-4 interleukin 6 Homo sapiens 86-90 8822343-7 1996 Treatment with hydrocortisone (1 microM), a known inhibitor of IL-6 production in many cell types, reduced IL-6 production to 17 +/- 1% of control (p < 0.001). Hydrocortisone 15-29 interleukin 6 Homo sapiens 63-67 8777274-3 1996 The release of IL-1 beta, IL-6 and TNF-alpha was correlated with total cholesterol at medium doses of LPS (100 ng/ml), and inversely correlated with lipopolysaccharide-binding protein (LBP) at low doses of LPS (1 ng/ml). Cholesterol 71-82 interleukin 6 Homo sapiens 26-30 8617307-0 1996 Interleukin-6 induces tyrosine phosphorylation of the Ras activating protein Shc, and its complex formation with Grb2 in the human multiple myeloma cell line LP-1. Tyrosine 22-30 interleukin 6 Homo sapiens 0-13 8822343-7 1996 Treatment with hydrocortisone (1 microM), a known inhibitor of IL-6 production in many cell types, reduced IL-6 production to 17 +/- 1% of control (p < 0.001). Hydrocortisone 15-29 interleukin 6 Homo sapiens 107-111 8822343-8 1996 As assessed by Northern analysis, treatment (n = 3 experiments) with 0.01-10 nM of 17 beta-estradiol decreased steady-state levels of IL-6 mRNA in a dose-dependent manner. Estradiol 83-100 interleukin 6 Homo sapiens 134-138 8838671-9 1996 Fibroblasts responded to the addition of dermatan sulfate, heparan sulfate and heparin with a decrease in fibronectin, collagenase and interleukin-6 mRNA. Dermatan Sulfate 41-57 interleukin 6 Homo sapiens 135-148 8838671-9 1996 Fibroblasts responded to the addition of dermatan sulfate, heparan sulfate and heparin with a decrease in fibronectin, collagenase and interleukin-6 mRNA. Heparin 79-86 interleukin 6 Homo sapiens 135-148 8890995-7 1996 There was a statistically significant correlation between the IL-6 peak concentration and the length of surgery in patients not treated with steroids, but not in patients treated with steroids. Steroids 141-149 interleukin 6 Homo sapiens 62-66 8821840-3 1996 Spontaneous release of tumour necrosis factor alpha (TNF alpha) and interleukins 6 (IL-6) by PM luminal diameter of, after 4 or 24 hours in culture, increased significantly with time on CAPD, while there was a small but significant decrease in release of prostaglandin E2 (PGE2). Dinoprostone 273-277 interleukin 6 Homo sapiens 68-88 8637711-2 1996 Interleukin-6 (IL-6) activates the junB promoter through an IL-6 response element, JRE-IL6, that is composed of two cooperative DNA motifs, a low affinity Stat-binding site overlapping with an Ets-binding site (JEBS) and a cAMP responsive element (CRE)-like site. Cyclic AMP 223-227 interleukin 6 Homo sapiens 0-13 8637711-2 1996 Interleukin-6 (IL-6) activates the junB promoter through an IL-6 response element, JRE-IL6, that is composed of two cooperative DNA motifs, a low affinity Stat-binding site overlapping with an Ets-binding site (JEBS) and a cAMP responsive element (CRE)-like site. Cyclic AMP 223-227 interleukin 6 Homo sapiens 15-19 8637711-2 1996 Interleukin-6 (IL-6) activates the junB promoter through an IL-6 response element, JRE-IL6, that is composed of two cooperative DNA motifs, a low affinity Stat-binding site overlapping with an Ets-binding site (JEBS) and a cAMP responsive element (CRE)-like site. Cyclic AMP 223-227 interleukin 6 Homo sapiens 60-64 8686529-11 1996 In monocytes, which are a major source of plasma IL-6, an elevation of intracellular cAMP stimulates the IL-6 synthesis. Cyclic AMP 85-89 interleukin 6 Homo sapiens 49-53 8686529-11 1996 In monocytes, which are a major source of plasma IL-6, an elevation of intracellular cAMP stimulates the IL-6 synthesis. Cyclic AMP 85-89 interleukin 6 Homo sapiens 105-109 8834013-7 1996 Reductions in circulating IL-6 and sIL-2R concentrations have also been observed with cyclosporin and corticosteroids, whereas azathioprine reduces IL-6 but not sIL-2R. Cyclosporine 86-97 interleukin 6 Homo sapiens 26-30 8772506-4 1996 IL-6 was also found to inhibit triacylglycerol secretion. Triglycerides 31-46 interleukin 6 Homo sapiens 0-4 8546573-11 1996 In addition, the IL-6-treated population produced more superoxide after 24 hours than did the untreated or heat-denature IL-6-treated groups, after either activating stimulus. Superoxides 55-65 interleukin 6 Homo sapiens 17-21 11856995-6 1996 We have found that small-sized Ti particles of phagocytosable size, a commonly encountered particle species in the periprosthetic tissues of failed THAs, stimulate macrophages to secrete various mediators of bone resorption (prostaglandin E(2), interleukin-1, interleukin-6, and tumor necrosis factor-alpha from macrophages and cause bone resorption in organ culture. Titanium 31-33 interleukin 6 Homo sapiens 260-273 8546573-12 1996 CONCLUSIONS: Interleukin-6 delays PMN apoptosis, resulting in a larger population of surviving PMNs with a greater collective capacity for superoxide production. Superoxides 139-149 interleukin 6 Homo sapiens 13-26 8742069-12 1996 Furthermore, medium supplemented with serum-free component or calcium also repressed IL-6 mRNA expression in PP fibroblasts in contrast to NN fibroblasts. Calcium 62-69 interleukin 6 Homo sapiens 85-89 8689424-4 1996 Platelet-rich plasma (PRP) specimens from bolus IL-6-treated patients demonstrated an increased incorporation of actin-binding protein and myosin in the cytoskeletal core (triton insoluble residue) as shown by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) in comparison to control specimens. Sodium Dodecyl Sulfate 210-232 interleukin 6 Homo sapiens 48-52 8689424-4 1996 Platelet-rich plasma (PRP) specimens from bolus IL-6-treated patients demonstrated an increased incorporation of actin-binding protein and myosin in the cytoskeletal core (triton insoluble residue) as shown by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) in comparison to control specimens. Sodium Dodecyl Sulfate 269-272 interleukin 6 Homo sapiens 48-52 8547658-0 1996 Inhibition of myeloma cell growth by dexamethasone and all-trans retinoic acid: synergy through modulation of interleukin-6 autocrine loop at multiple sites. Dexamethasone 37-50 interleukin 6 Homo sapiens 110-123 8547658-0 1996 Inhibition of myeloma cell growth by dexamethasone and all-trans retinoic acid: synergy through modulation of interleukin-6 autocrine loop at multiple sites. Tretinoin 65-78 interleukin 6 Homo sapiens 110-123 8547658-2 1996 We investigated the effect of dexamethasone and all-trans retinoic acid, previously shown to modulate IL-6/IL-6R, on the in vitro growth of a human myeloma cell line, OPM-2. Dexamethasone 30-43 interleukin 6 Homo sapiens 102-106 8547658-2 1996 We investigated the effect of dexamethasone and all-trans retinoic acid, previously shown to modulate IL-6/IL-6R, on the in vitro growth of a human myeloma cell line, OPM-2. Tretinoin 58-71 interleukin 6 Homo sapiens 102-106 8547658-7 1996 The effect of dexamethasone but not all-trans retinoic acid was completely reversed by exogenous IL-6. Dexamethasone 14-27 interleukin 6 Homo sapiens 97-101 8547658-11 1996 IL-6 mRNA expression was reduced by dexamethasone and the combination, but was not affected by retinoic acid alone. Dexamethasone 36-49 interleukin 6 Homo sapiens 0-4 8861665-15 1996 Of the proteins, only interleukin-6 was significantly reduced (45 percent, P <0.05) by IBU as compared to PLA pretreatment. Ibuprofen 90-93 interleukin 6 Homo sapiens 22-35 8803706-6 1996 The IL-6 values immediately after operation, as well as at postoperative days 1 and 3 in the steroid pulse group were significantly lower than those in the control group. Steroids 93-100 interleukin 6 Homo sapiens 4-8 8904180-2 1996 Dexamethasone, an inhibitor of cytokine production, inhibited LPS-induced tissue factor and IL-6 release by mononuclear cells (MNC), but enhanced IL-1beta-evoked tissue factor activity. Dexamethasone 0-13 interleukin 6 Homo sapiens 92-96 8536785-7 1996 IL-1 alpha-induced GM-CSF, IL-1 beta, IL-6, IL-11, and LIF mRNA levels were reduced by the addition of dexamethasone, whereas dexamethasone had no influence on the amounts of IL-1 alpha-induced G-CSF mRNA. Dexamethasone 103-116 interleukin 6 Homo sapiens 38-42 8550757-3 1996 To measure corticosteroid sensitivity, we developed an assay based on the inhibition by dexamethasone (Dex) of lipopolysaccharide (LPS)-induced Interleukin-6 (IL-6) production and release in whole unseparated blood in vitro. Dexamethasone 88-101 interleukin 6 Homo sapiens 144-157 8550757-3 1996 To measure corticosteroid sensitivity, we developed an assay based on the inhibition by dexamethasone (Dex) of lipopolysaccharide (LPS)-induced Interleukin-6 (IL-6) production and release in whole unseparated blood in vitro. Dexamethasone 88-101 interleukin 6 Homo sapiens 159-163 8550757-3 1996 To measure corticosteroid sensitivity, we developed an assay based on the inhibition by dexamethasone (Dex) of lipopolysaccharide (LPS)-induced Interleukin-6 (IL-6) production and release in whole unseparated blood in vitro. Dexamethasone 103-106 interleukin 6 Homo sapiens 144-157 8550757-3 1996 To measure corticosteroid sensitivity, we developed an assay based on the inhibition by dexamethasone (Dex) of lipopolysaccharide (LPS)-induced Interleukin-6 (IL-6) production and release in whole unseparated blood in vitro. Dexamethasone 103-106 interleukin 6 Homo sapiens 159-163 8550757-4 1996 LPS induced a dose-dependent increase in IL-6 concentrations up to 34 +/- 6.6 ng/mL, reaching plateau levels after 8 h, whereas Dex dose dependently inhibited LPS-induced IL-6 production. Dexamethasone 128-131 interleukin 6 Homo sapiens 171-175 8550757-5 1996 Involvement of the glucocorticoid receptor in this response was supported by abrogation of Dex (10(-7) mol/L) inhibition of IL-6 production by the glucocorticoid receptor antagonist RU 38486. Dexamethasone 91-94 interleukin 6 Homo sapiens 124-128 8550757-7 1996 Before exercise, 3 x 10(-8) mol/L Dex inhibited LPS-induced IL-6 production in vitro; after exercise, 3 x 10(-8) and 10(-7) mol/L Dex were unable to inhibit IL-6 production. Dexamethasone 34-37 interleukin 6 Homo sapiens 60-64 8550757-8 1996 We conclude that Dex suppression of LPS-induced IL-6 production is an effective means of determining corticosteroid sensitivity, and that corticosteroid sensitivity in human subjects is a dynamic, rather than a static, phenomenon. Dexamethasone 17-20 interleukin 6 Homo sapiens 48-52 8592085-3 1996 Transcription of IL-6 mRNA was first detectable 2 h after stimulation with the ester phorbol myristate acetate (PMA) and the calcium ionophore A23187 in both cell lines, as evidenced by semiquantitative reverse transcriptase polymerase chain reaction analysis. Tetradecanoylphorbol Acetate 85-110 interleukin 6 Homo sapiens 17-21 8592085-3 1996 Transcription of IL-6 mRNA was first detectable 2 h after stimulation with the ester phorbol myristate acetate (PMA) and the calcium ionophore A23187 in both cell lines, as evidenced by semiquantitative reverse transcriptase polymerase chain reaction analysis. Tetradecanoylphorbol Acetate 112-115 interleukin 6 Homo sapiens 17-21 8592085-3 1996 Transcription of IL-6 mRNA was first detectable 2 h after stimulation with the ester phorbol myristate acetate (PMA) and the calcium ionophore A23187 in both cell lines, as evidenced by semiquantitative reverse transcriptase polymerase chain reaction analysis. Calcium 125-132 interleukin 6 Homo sapiens 17-21 16873161-3 1996 There was a positive correlation between concentrations of IL-1&beta; and IL-6. Adenosine Monophosphate 64-67 interleukin 6 Homo sapiens 78-82 8632663-3 1995 TPA treatment also enhanced the expression of GPIIb mRNA, and induced the expression of interleukin-6 (IL-6) and its receptor mRNAs, while it did not induce transcripts of the genes IL-11 and mpl ligand, and further decreased the transcript of the mpl gene. Tetradecanoylphorbol Acetate 0-3 interleukin 6 Homo sapiens 88-101 8614289-0 1996 Relationship between cAMP induced inhibition of human meningioma cell proliferation and autocrine secretion of interleukin-6. Cyclic AMP 21-25 interleukin 6 Homo sapiens 111-124 18475705-1 1996 In order to find an explanation for corticosteroid resistance we assessed whether inhibition by dexamethasone (DEX) of the stimulated production of TNF- proportional, variant, IL-6, PGE(2) and LTB(4) by peripheral blood mononuclear cells (MNC) depends on binding to the glucocorticoid receptor (GR), and whether it is determined by the number or the affinity of the GR of these cells. Dexamethasone 96-109 interleukin 6 Homo sapiens 176-180 18475705-1 1996 In order to find an explanation for corticosteroid resistance we assessed whether inhibition by dexamethasone (DEX) of the stimulated production of TNF- proportional, variant, IL-6, PGE(2) and LTB(4) by peripheral blood mononuclear cells (MNC) depends on binding to the glucocorticoid receptor (GR), and whether it is determined by the number or the affinity of the GR of these cells. Dexamethasone 111-114 interleukin 6 Homo sapiens 176-180 18475705-4 1996 DEX caused a concentration dependent inhibition of TNF- proportional, variant, IL-6 and PGE(2) production but had no effect on LTB(4) production. Dexamethasone 0-3 interleukin 6 Homo sapiens 79-83 10388012-16 1996 In the same manner, the IL-6, LIF and oncostatin M (OSM) receptors all share gp130, which is the &bgr; subunit of the IL-6 receptor. Adenosine Monophosphate 98-101 interleukin 6 Homo sapiens 24-28 10388012-16 1996 In the same manner, the IL-6, LIF and oncostatin M (OSM) receptors all share gp130, which is the &bgr; subunit of the IL-6 receptor. Adenosine Monophosphate 98-101 interleukin 6 Homo sapiens 122-126 7595543-6 1995 The phorbol ester 12-O-tetradecanoylphorbol 13-acetate induced interleukin-6 production, and treatment with a combination of this phorbol ester and interleukin-1 produced synergistic stimulation. Tetradecanoylphorbol Acetate 18-54 interleukin 6 Homo sapiens 63-76 8523572-6 1996 IL-6 induction by EBV was inhibited with the PKC-specific inhibitor bisindolylmaleimide or the protein tyrosine kinase inhibitors methyl 2,5-dihydroxycinnamate and herbimycin A, indicating that the induction of IL-6 following CD21 cross-linking is mediated through PKC- and protein tyrosine kinase-dependent pathways. methyl 2,5-dihydroxycinnamate 130-159 interleukin 6 Homo sapiens 0-4 8523572-6 1996 IL-6 induction by EBV was inhibited with the PKC-specific inhibitor bisindolylmaleimide or the protein tyrosine kinase inhibitors methyl 2,5-dihydroxycinnamate and herbimycin A, indicating that the induction of IL-6 following CD21 cross-linking is mediated through PKC- and protein tyrosine kinase-dependent pathways. methyl 2,5-dihydroxycinnamate 130-159 interleukin 6 Homo sapiens 211-215 8805102-5 1996 Prostaglandin E2 depressed the production of IL-1 alpha, while it up-regulated the production of IL-6, TNF-alpha, and IFN-gamma. Dinoprostone 0-16 interleukin 6 Homo sapiens 97-101 8805102-6 1996 Rapamycin depressed the production of IL-6 and TNF-alpha, and FK506 depressed the production of TNF-alpha. Sirolimus 0-9 interleukin 6 Homo sapiens 38-42 16764118-7 1996 The majority of these substances (TNFalpha, IL-1, IL-2, IL-3, IL-6) can stimulate the prostaglandin-biosynthesis by intrauterine tissues (amnion, chorion, decidua), some of them have antiinflammatory effects (IL-10, transforming growth factor alpha). Prostaglandins 86-99 interleukin 6 Homo sapiens 62-66 8845574-7 1995 Finally, in the next years, there will be a wider diffusion of biotherapies in MM that should take into account the roles that IL-1 beta and TNF alpha play in myeloma cell proliferation and bone destruction and the finding that retinoic acid is capable of inhibiting the growth of human myeloma cells in vitro through modulation of IL-6 and its receptor. Tretinoin 228-241 interleukin 6 Homo sapiens 332-336 8929646-0 1995 Glomerular localization of interleukin-6 suppressed by steroid mini-pulse therapy in an IgA nephropathy patient. Steroids 55-62 interleukin 6 Homo sapiens 27-40 8587236-0 1995 Interleukin-1-induced IL-8 and IL-6 gene expression and production in human mesangial cells is differentially regulated by cAMP. Cyclic AMP 123-127 interleukin 6 Homo sapiens 31-35 8587236-2 1995 The objective of this study was to investigate the role of cAMP in the regulation of IL-6 and IL-8 gene expression and peptide production in IL-1 stimulated human MC. Cyclic AMP 59-63 interleukin 6 Homo sapiens 85-89 8587236-8 1995 Thus our data show that cAMP can potentiate IL-1 induced IL-6 production, while having no effect on IL-8 induction, and PGE2 may operate via a positive feedback loop to up-regulate IL-1 induced IL-6. Cyclic AMP 24-28 interleukin 6 Homo sapiens 57-61 8587236-8 1995 Thus our data show that cAMP can potentiate IL-1 induced IL-6 production, while having no effect on IL-8 induction, and PGE2 may operate via a positive feedback loop to up-regulate IL-1 induced IL-6. Dinoprostone 120-124 interleukin 6 Homo sapiens 194-198 8587236-9 1995 Taken together, our results demonstrate that cAMP differentially regulates IL-6 and IL-8 production in IL-1-stimulated human MC. Cyclic AMP 45-49 interleukin 6 Homo sapiens 75-79 8632663-3 1995 TPA treatment also enhanced the expression of GPIIb mRNA, and induced the expression of interleukin-6 (IL-6) and its receptor mRNAs, while it did not induce transcripts of the genes IL-11 and mpl ligand, and further decreased the transcript of the mpl gene. Tetradecanoylphorbol Acetate 0-3 interleukin 6 Homo sapiens 103-107 7579337-7 1995 Preincubation of mast cells with SCF, IL-4, IL-5, or IL-6 for 24 hours during sensitization with IgE enhanced IgE/anti-IgE antibody-induced histamine release from mast cells, whereas IL-3 showed a negligible effect. Histamine 140-149 interleukin 6 Homo sapiens 53-57 8599808-5 1995 Oxygen radicals act as second messenger for the activation of cytokines via NF-kappaB transcription factor, they stimulate the formation of TNF-alpha, IL-1, IL-6 and influence the expression of monocyte-specific cytokines (CSF-1 and MCP-1). Reactive Oxygen Species 0-15 interleukin 6 Homo sapiens 157-161 7594494-8 1995 This loss of phosphate labeling of p36/38 is accompanied by an inhibition of TNF-alpha and Il-6 mRNA and protein production. Phosphates 13-22 interleukin 6 Homo sapiens 91-95 21153120-0 1995 Effect of 17beta-oestradiol on expression of IL-2, IL-6 and IFN-gamma mRNA in human tonsillar cells. Estradiol 10-27 interleukin 6 Homo sapiens 51-55 8535797-7 1995 There were increases in IL-6 and alpha 2M concentrations in TNBS-E-treated animals but no significant change in TNF concentrations. Trinitrobenzenesulfonic Acid 60-64 interleukin 6 Homo sapiens 24-28 8821030-3 1995 Increased 3H thymidine incorporation and proliferative effect of HSF by kappa E (1.3 to 2.2 fold as compared to control cells) was observed after a lag phase period which raised with initial HSF density. Tritium 10-12 interleukin 6 Homo sapiens 191-194 8785878-21 1995 If a genetic defect decreases the affinity of a suppressive receptor/ligand complex for the regulatory element of IL-6 or TGF-alpha, for example, then these cells could be relatively resistant to homeostatic regulation by indigenous corticosteroids, vitamin D, and retinoids. Vitamin D 250-259 interleukin 6 Homo sapiens 114-118 7490793-0 1995 In vitro production of interleukin-6 by human gingival, normal buccal mucosa, and oral submucous fibrosis fibroblasts treated with betel-nut alkaloids. betel-nut alkaloids 131-150 interleukin 6 Homo sapiens 23-36 7490793-1 1995 This study aimed to assess the possibility of a direct effect of betel-nut alkaloids arecoline and arecaidine on cell proliferation and interleukin-6 (IL-6) production by cultured fibroblasts from human normal gingiva, buccal mucosa and oral submucous fibrosis (OSF) buccal mucosa in vitro. arecaidine 99-109 interleukin 6 Homo sapiens 136-149 7490793-9 1995 However, two of six individuals" normal buccal mucosa fibroblasts significantly released less IL-6, and some cases of OSF and healthy gingiva exhibited slightly higher levels of IL-6 when cells were exposed to arecoline or arecaidine in cultures. arecaidine 223-233 interleukin 6 Homo sapiens 178-182 7490793-10 1995 Such findings suggests that arecoline and arecaidine can enhance cell proliferation and affect fibroblasts to synthesize IL-6. arecaidine 42-52 interleukin 6 Homo sapiens 121-125 7580291-3 1995 Histamine, but not PAF or endothelin-1, showed a dose-dependent stimulatory effect on the release of interleukin-6, interleukin-8 and granulocyte-macrophage colony-stimulating factor by normal and transformed human bronchial epithelial cells when studied 6 h after the treatment. Histamine 0-9 interleukin 6 Homo sapiens 101-114 7553641-0 1995 Endogenous interleukin 6 is a resistance factor for cis-diamminedichloroplatinum and etoposide-mediated cytotoxicity of human prostate carcinoma cell lines. Cisplatin 52-80 interleukin 6 Homo sapiens 11-24 7553641-10 1995 CDDP treatment of tumor cells down-regulated IL-6 mRNA expression and IL-6 secretion. Cisplatin 0-4 interleukin 6 Homo sapiens 45-49 7553641-10 1995 CDDP treatment of tumor cells down-regulated IL-6 mRNA expression and IL-6 secretion. Cisplatin 0-4 interleukin 6 Homo sapiens 70-74 7592638-5 1995 Gel mobility shift assays using 25-base pair oligonucleotide probes derived from these three regions with the CTGGGA positioned in the middle and nuclear extracts from IL-6-treated primary hepatocytes reveal the presence of IL-6-induced high molecular weight complexes appearing 5 min after cytokine treatment. Oligonucleotides 45-60 interleukin 6 Homo sapiens 224-228 7490545-8 1995 The abilities of oestradiol or tamoxifen to potentiate or inhibit the IL-6 stimulation of oestrogen synthesis in breast cancer cells may result from their effects on IL-6sR release. Estradiol 17-27 interleukin 6 Homo sapiens 70-74 7490545-8 1995 The abilities of oestradiol or tamoxifen to potentiate or inhibit the IL-6 stimulation of oestrogen synthesis in breast cancer cells may result from their effects on IL-6sR release. Tamoxifen 31-40 interleukin 6 Homo sapiens 70-74 7561108-9 1995 Pretreatment of EC with the tyrosine kinase inhibitor, herbimycin A, inhibited LPS-stimulated protein tyrosine phosphorylation and LPS-mediated lactic dehydrogenase release from BBMEC and IL-6 release from HBMEC in a dose-dependent manner. Tyrosine 28-36 interleukin 6 Homo sapiens 188-192 7556963-3 1995 To elucidate the expression and localization of IL-6 mRNA in renal tissues of patients with DN, a high-resolution in situ hybridization using digoxigenin-labeled oligonucleotide was performed. Oligonucleotides 162-177 interleukin 6 Homo sapiens 48-52 7561521-4 1995 Anti-GM-CSF and anti-IL-6 antibodies markedly blocked cytokine activity in CM-PBS, whereas the blocking effect in CM-histamine was moderate, indicating enhanced GM-CSF and IL-6 activity in CM-histamine. Histamine 192-201 interleukin 6 Homo sapiens 172-176 7589600-3 1995 Following ibuprofen administration there were reductions in circulating concentrations of C-reactive protein (P = 0.01), interleukin-6 (P = 0.06), cortisol (P = 0.04) and also in the platelet count (P = 0.01). Ibuprofen 10-19 interleukin 6 Homo sapiens 121-134 7589600-5 1995 These results indicate that ibuprofen administered over a prolonged period substantially reduces acute protein production via its effect on interleukin-6 and cortisol. Ibuprofen 28-37 interleukin 6 Homo sapiens 140-153 7561521-0 1995 Histamine enhances granulocyte-macrophage colony-stimulating factor and interleukin-6 production by human peripheral blood mononuclear cells. Histamine 0-9 interleukin 6 Homo sapiens 72-85 7561521-7 1995 We conclude that histamine is able to activate human mononuclear cells to generate cytokines such as GM-CSF and IL-6 via H1 and H2 receptors. Histamine 17-26 interleukin 6 Homo sapiens 112-116 7561521-3 1995 Using ELISA and radioimmunoassay kits, histamine was found to enhance the production of GM-CSF (9.6-fold) and IL-6 (8.2-fold) by mononuclear cells but not by nonadherent cells or large granular lymphocytes. Histamine 39-48 interleukin 6 Homo sapiens 110-114 7656331-0 1995 B cell differentiation factor-induced human B cell maturation: stimulation of intracellular calcium release. Calcium 92-99 interleukin 6 Homo sapiens 0-29 7566966-0 1995 Cyclic AMP stimulates a JunD/Fra-2 AP-1 complex and inhibits the proliferation of interleukin-6-dependent cell lines. Cyclic AMP 0-10 interleukin 6 Homo sapiens 82-95 7566966-2 1995 We demonstrate that elevation of cAMP cellular content inhibits IL-6-stimulated cell growth, by blocking cells mainly in G1 phase. Cyclic AMP 33-37 interleukin 6 Homo sapiens 64-68 7558422-5 1995 A similar inhibitory action of IL-6 was observed on the glucocorticoid dexamethasone (DEX)-induced apo-D and GC-DFP-15 secretion. Dexamethasone 71-84 interleukin 6 Homo sapiens 31-35 7558422-5 1995 A similar inhibitory action of IL-6 was observed on the glucocorticoid dexamethasone (DEX)-induced apo-D and GC-DFP-15 secretion. Dexamethasone 86-89 interleukin 6 Homo sapiens 31-35 7558422-7 1995 The inhibitory effect of IL-6 on the secretion of these two biochemical markers was additive to that of 17 beta-estradiol. Estradiol 104-121 interleukin 6 Homo sapiens 25-29 7677475-3 1995 METHODS: This initial study evaluated the impact of heparin-bonded CPB circuits on production of the cytokines interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-a), IL-6, and IL-8 in adults undergoing complex cardiac operations with prolonged CPB. Heparin 52-59 interleukin 6 Homo sapiens 170-174 7677475-6 1995 RESULTS: The levels of IL-6 and IL-8 increased in a time-dependent fashion in both groups, but the response was significantly less over time in the heparin-bonded group (p < 0.05) for both IL-6 and IL-8. Heparin 148-155 interleukin 6 Homo sapiens 23-27 7677475-6 1995 RESULTS: The levels of IL-6 and IL-8 increased in a time-dependent fashion in both groups, but the response was significantly less over time in the heparin-bonded group (p < 0.05) for both IL-6 and IL-8. Heparin 148-155 interleukin 6 Homo sapiens 192-196 8562921-5 1995 A mechanism likely to contribute to hypoxia-mediated generation of cytokines, such as interleukin 6, is activation of the transcription factor NF-IL-6, which occurs in oxygen deprivation. Oxygen 168-174 interleukin 6 Homo sapiens 86-99 7665990-0 1995 Inhibition of superantigen-induced T cell proliferation and monocyte IL-1 beta, TNF-alpha, and IL-6 production by acute ethanol treatment. Ethanol 120-127 interleukin 6 Homo sapiens 95-99 7665990-3 1995 Furthermore, ethanol treatment (25-100 mM) significantly inhibited SEA- or SEB-induced production of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and IL-6 in monocytes. Ethanol 13-20 interleukin 6 Homo sapiens 178-182 7665990-4 1995 Ethanol-induced down-regulation of monocyte TNF-alpha, IL-1 beta, and IL-6 occurred at both the protein and mRNA levels. Ethanol 0-7 interleukin 6 Homo sapiens 70-74 7642569-10 1995 We tested the hypothesis that AII initially activated an inhibitory pathway, which was responsible for delaying the maximal SIF stimulation until 2 h. Pretreatment of cells for 15 min with AII resulted in significant inhibition of the IL-6 induced nuclear SIF response (10 min) and Stat92 tyrosine phosphorylation, which was blocked by EXP3174, an AT1 receptor antagonist. Tyrosine 289-297 interleukin 6 Homo sapiens 235-239 7581842-1 1995 A new mutein of interleukin-6, called delta 22-IL-6 Cys 3,4, characterized by the deletion of the first 22 amino acids at the N-terminal end and by the substitution of the first two cysteines (Cys23 and Cys29) with serine residues, was produced in Escherichia coli and was found to maintain the structural and functional properties of the human native form. Cysteine 52-55 interleukin 6 Homo sapiens 16-29 7581842-1 1995 A new mutein of interleukin-6, called delta 22-IL-6 Cys 3,4, characterized by the deletion of the first 22 amino acids at the N-terminal end and by the substitution of the first two cysteines (Cys23 and Cys29) with serine residues, was produced in Escherichia coli and was found to maintain the structural and functional properties of the human native form. Cysteine 182-191 interleukin 6 Homo sapiens 16-29 7642569-12 1995 Pretreatment of cells with phorbol 12-myristate 13-acetate for 15 min, to activate protein kinase C, resulted in inhibition of the IL-6-induced SIF response (10 min). Tetradecanoylphorbol Acetate 27-58 interleukin 6 Homo sapiens 131-135 7496871-6 1995 Addition of dexamethasone resulted in a reduction of TNF, IL-1 and IL-6 release to below background levels. Dexamethasone 12-25 interleukin 6 Homo sapiens 67-71 7649255-2 1995 To investigate the importance of this region for biological activity of IL-6, residues Glu-52, Ser-53, Ser-54, Lys-55, Glu-56, Leu-58, and Glu-60 were individually replaced by alanine. Alanine 176-183 interleukin 6 Homo sapiens 72-76 7593327-2 1995 In addition, the cAMP increasing agents attenuated the increase in HSP70 mRNA and protein levels produced by cadmium chloride in U-937 and other human myeloid cell lines, reduced the capacity of cadmium treatment to generate stress-tolerance, and attenuated the cadmium-produced stimulation of heat-shock factor (HSF) binding activity. Cyclic AMP 17-21 interleukin 6 Homo sapiens 294-311 7542635-4 1995 Our results show that a GSL containing four sugar residues (GSL-4A) induced the release of tumor necrosis factor, interleukin-6, and interleukin-1 in MNC, whereas GSL-1, containing only one glycosyl residue, was inactive. Glycosphingolipids 24-27 interleukin 6 Homo sapiens 114-127 7593327-2 1995 In addition, the cAMP increasing agents attenuated the increase in HSP70 mRNA and protein levels produced by cadmium chloride in U-937 and other human myeloid cell lines, reduced the capacity of cadmium treatment to generate stress-tolerance, and attenuated the cadmium-produced stimulation of heat-shock factor (HSF) binding activity. Cyclic AMP 17-21 interleukin 6 Homo sapiens 313-316 7593327-6 1995 It is concluded that cAMP does not inhibit the stress response as a whole, but it interferes with some step of the pathway by which cadmium specifically stimulates HSF binding activity and as a consequence HSP70 gene expression, in human myeloid cell lines. Cyclic AMP 21-25 interleukin 6 Homo sapiens 164-167 7593327-6 1995 It is concluded that cAMP does not inhibit the stress response as a whole, but it interferes with some step of the pathway by which cadmium specifically stimulates HSF binding activity and as a consequence HSP70 gene expression, in human myeloid cell lines. Cadmium 132-139 interleukin 6 Homo sapiens 164-167 8520508-0 1995 An interleukin 1 receptor antagonist blocks the IL-1-induced IL-6 paracrine production through a prostaglandin E2-related mechanism in multiple myeloma. Dinoprostone 97-113 interleukin 6 Homo sapiens 61-65 8523010-6 1995 An apparent inverse relation between interleukin-1 alpha and interleukin-6 interfacial membranes of total hip arthroplasties compared with control synovial tissues suggests a complex cellular mechanism through a cytokine/prostaglandin cascade; this may regulate the observed bone resorption in aseptic loosening. Prostaglandins 221-234 interleukin 6 Homo sapiens 61-74 8520508-2 1995 We show that PGE2 is produced in short-term cultures of bone marrow cells of patients with MM, concomitantly with both IL-6 and IL-1. Dinoprostone 13-17 interleukin 6 Homo sapiens 119-123 8520508-4 1995 Exogenous PGE2 reverses this inhibition or even stimulates IL-6 production. Dinoprostone 10-14 interleukin 6 Homo sapiens 59-63 7638755-13 1995 CONCLUSIONS: These results indicate that inhaled cyclosporine is effective therapy for refractory pulmonary rejection and that its mechanism of action is associated with suppression of proinflammatory cytokines IL-6 and interferon-gamma within the allograft. Cyclosporine 49-61 interleukin 6 Homo sapiens 211-215 8520508-6 1995 The inhibition of IL-6 production is reversed by adding exogenous PGE2. Dinoprostone 66-70 interleukin 6 Homo sapiens 18-22 7638758-2 1995 In that study, subjects with vastly exaggerated levels of tumor necrosis factor (TNF) and interleukin (IL)-6 12 and 144 hours after cortisol infusion exhibited hemodynamic and hormonal responses no different from those of untreated subjects after endotoxin. Hydrocortisone 132-140 interleukin 6 Homo sapiens 90-108 8520508-7 1995 These results show that induction of IL-6 by IL-1 is related to PGE2 in the bone marrow of patients with MM. Dinoprostone 64-68 interleukin 6 Homo sapiens 37-41 8520508-8 1995 Inhibition of PGE2 synthesis (as obtained with indomethacin and the IL-1RA) might be helpful to inhibit myeloma cell proliferation by reducing IL-1-induced endogenous IL-6 production not only in vitro (as demonstrated here) but also in vivo. Dinoprostone 14-18 interleukin 6 Homo sapiens 167-171 7539384-10 1995 Evidence for autocrine regulation of this cell line by IL-6 was demonstrated by the inhibitory effects of an antisense oligonucleotide on 3H-thymidine (3H-TdR) incorporation. Oligonucleotides 119-134 interleukin 6 Homo sapiens 55-59 7668576-0 1995 Regulation of interleukin-6 gene expression by steroids. Steroids 47-55 interleukin 6 Homo sapiens 14-27 7619053-3 1995 Furthermore, IFN-alpha inhibits the ability of IL-6 to induce increases in [3H]thymidine incorporation. Tritium 76-78 interleukin 6 Homo sapiens 47-51 7647014-0 1995 The gp 130 family cytokines IL-6, LIF and OSM but not IL-11 can reverse the anti-proliferative effect of dexamethasone on human myeloma cells. Dexamethasone 105-118 interleukin 6 Homo sapiens 28-32 7647014-6 1995 Therefore the high levels of IL-6 (ng/ml) observed in the MM intermediate milieu and the putative presence of LIF and OSM can easily counteract the effects of dexamethasone in vivo. Dexamethasone 159-172 interleukin 6 Homo sapiens 29-33 8603657-2 1995 The external Cd dose was evaluated in terms of daily Cd intake via food (Cd-F), whereas Cd levels in blood (Cd-B) and urine (Cd-U) were taken as internal dose indicators. Cadmium 13-15 interleukin 6 Homo sapiens 73-77 7590603-8 1995 In the perfusion experiment, 100 ng/ml of IL-6 suppressed LH (100ng/ml)-induced estradiol (E2) secretion but did not influence progesterone (P4) secretion, while IL-2 had no effect on steroid secretion. Estradiol 80-89 interleukin 6 Homo sapiens 42-46 7590603-8 1995 In the perfusion experiment, 100 ng/ml of IL-6 suppressed LH (100ng/ml)-induced estradiol (E2) secretion but did not influence progesterone (P4) secretion, while IL-2 had no effect on steroid secretion. Steroids 184-191 interleukin 6 Homo sapiens 42-46 7631148-4 1995 After treatment with the phorbol ester TPA or the calcium ionophore ionomycin expression of several cytokines, i.e. IL-1 beta, IL-3, IL-6, GM-CSF, TNF-beta and PDGF-A, could be detected. Ionomycin 68-77 interleukin 6 Homo sapiens 133-137 7598715-7 1995 Differently than estrogen, LY 139478 at high dose significantly reduced IL-6 release by these cells. Lysine 27-29 interleukin 6 Homo sapiens 72-76 7581271-1 1995 Porphyromonas gingivalis 381 fimbriae and a synthetic peptide composed of residues 69-73 (ALTTE) of the fimbrial subunit protein, FP381(69-73), function in the induction of interleukin 6 (IL-6) production, IL-6 mRNA expression, and tyrosine and serine/threonine phosphorylation of several proteins in human peripheral blood mononuclear cells (PBMC). Tyrosine 232-240 interleukin 6 Homo sapiens 173-186 7581271-1 1995 Porphyromonas gingivalis 381 fimbriae and a synthetic peptide composed of residues 69-73 (ALTTE) of the fimbrial subunit protein, FP381(69-73), function in the induction of interleukin 6 (IL-6) production, IL-6 mRNA expression, and tyrosine and serine/threonine phosphorylation of several proteins in human peripheral blood mononuclear cells (PBMC). Serine 245-251 interleukin 6 Homo sapiens 173-186 7581271-1 1995 Porphyromonas gingivalis 381 fimbriae and a synthetic peptide composed of residues 69-73 (ALTTE) of the fimbrial subunit protein, FP381(69-73), function in the induction of interleukin 6 (IL-6) production, IL-6 mRNA expression, and tyrosine and serine/threonine phosphorylation of several proteins in human peripheral blood mononuclear cells (PBMC). Threonine 252-261 interleukin 6 Homo sapiens 173-186 7581271-2 1995 Herbimycin A and H-7, inhibitors of tyrosine kinases and protein kinase C (PKC), markedly inhibited IL-6 production, gene expression, and tyrosine and serine/threonine phosphorylation of proteins. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 17-20 interleukin 6 Homo sapiens 100-104 8573814-5 1995 In addition, glucose metabolism, urea synthesis, P450 dependent verapamil metabolism using high performance liquid chromatography, and interleukin-6 induced "acute phase" reaction by sulfodesoxysalicylic acid-polyacrylamide gel electrophoresis detected changes of albumin synthesis were determined in primary hepatocytes and in established liver cells. sulfodesoxysalicylic acid 183-208 interleukin 6 Homo sapiens 135-148 7601249-7 1995 Expression of the IL-5, IL-6, and IL-10 genes was resistant to cyclosporine A (CsA), whereas IL-3 and IL-4 gene expression was completely inhibited, indicating the involvement of different signalling pathways in the regulation of these genes. Cyclosporine 63-77 interleukin 6 Homo sapiens 24-28 7601249-7 1995 Expression of the IL-5, IL-6, and IL-10 genes was resistant to cyclosporine A (CsA), whereas IL-3 and IL-4 gene expression was completely inhibited, indicating the involvement of different signalling pathways in the regulation of these genes. Cyclosporine 79-82 interleukin 6 Homo sapiens 24-28 7615975-4 1995 Transforming growth factor (TGF)-alpha, epidermal growth factor, and phorbol myristate acetate also enhanced the secretion of VPF/VEGF by keratinocytes; in contrast, a number of other cytokines including interleukin (IL)-1, IL-6, IL-8, tumor necrosis factor-alpha, interferon-gamma, and transforming growth factor-beta did not induce VPF/VEGF secretion. Tetradecanoylphorbol Acetate 69-94 interleukin 6 Homo sapiens 224-228 7669718-2 1995 There was a higher expression of bcl-XL in cells treated with DEX or DEX plus IL-6 compared to cells treated with IL-6 alone. Dexamethasone 69-72 interleukin 6 Homo sapiens 114-118 7669718-4 1995 Treatment with IL-6 increased the susceptibility of these cells to induction of apoptosis by Adriamycin or cycloheximide, but treatment with DEX or with IL-6 and DEX did not. Doxorubicin 93-103 interleukin 6 Homo sapiens 15-19 7539384-10 1995 Evidence for autocrine regulation of this cell line by IL-6 was demonstrated by the inhibitory effects of an antisense oligonucleotide on 3H-thymidine (3H-TdR) incorporation. Tritium 138-140 interleukin 6 Homo sapiens 55-59 7769130-5 1995 In addition, testosterone, dihydrotestosterone, and adrenal androgens inhibited the expression of a chloramphenicol acetyl transferase reporter plasmid driven by the human IL-6 promoter in HeLa cells cotransfected with an androgen receptor expression plasmid; however, these steroids were ineffective when the cells were cotransfected with an estrogen receptor expression plasmid. Steroids 275-283 interleukin 6 Homo sapiens 172-176 7572320-0 1995 Interleukin-6 and the acute phase response during treatment of patients with Paget"s disease with the nitrogen-containing bisphosphonate dimethylaminohydroxypropylidene bisphosphonate. Nitrogen 102-110 interleukin 6 Homo sapiens 0-13 7769130-5 1995 In addition, testosterone, dihydrotestosterone, and adrenal androgens inhibited the expression of a chloramphenicol acetyl transferase reporter plasmid driven by the human IL-6 promoter in HeLa cells cotransfected with an androgen receptor expression plasmid; however, these steroids were ineffective when the cells were cotransfected with an estrogen receptor expression plasmid. Testosterone 13-25 interleukin 6 Homo sapiens 172-176 7743552-7 1995 Addition of IL-6 (but not IL-1 beta, IL-4, IL-7, or IL-10) inhibited PCD of 8226 targets induced by serum starvation or dexamethasone in a concentration-dependent fashion. Dexamethasone 120-133 interleukin 6 Homo sapiens 12-16 7744875-4 1995 In good agreement with our structural model, substitutions at Asn-230, His-280, and Asp-281 selectively impaired the capability of shIL-6R alpha to associate with hgp130 both in vitro and on the cell surface, without affecting its affinity for hIL-6. Histidine 71-74 interleukin 6 Homo sapiens 132-137 7775626-9 1995 To a lesser extent, the combination of interleukin-1, interleukin-6, and tumor necrosis factor-alpha also counteracted the effects of dexamethasone. Dexamethasone 134-147 interleukin 6 Homo sapiens 54-67 7674242-7 1995 IL-1 induced IL-6 release was inhibited by ibuprofen and the salicylates where as IL-1 induced APMA-activated collagenase was only inhibited by the salicylates. Ibuprofen 43-52 interleukin 6 Homo sapiens 13-17 7611579-19 1995 The elevation of the plasma catecholamines immediately after SNP administration should also be taken into account, because an augmentation of the cAMP in various cell types has been proven to result in increased release of IL-6. Cyclic AMP 146-150 interleukin 6 Homo sapiens 223-227 7743552-10 1995 Targets protected from PCD by IL-6 were still sensitive to serum starvation and dex-induced cytostasis, but, after reculturing in drug-free complete media, they reinitiated normal proliferation. Dexamethasone 80-83 interleukin 6 Homo sapiens 30-34 7542063-3 1995 IL-4, but not SCF, enhanced ionomycin-induced transcription and secretion of several genes, including the cytokines IL-3, IL-4, granulocyte/macrophage-colony-stimulating factor, IL-8 and the receptor for IL-6 in the human HMC-1 mast cell line. Ionomycin 28-37 interleukin 6 Homo sapiens 204-208 7635234-8 1995 The concentration of IL-6 parallels the reported levels of PGE2, and it is therefore likely that if IL-6 is involved in the mechanism of labour it acts through the effects of the resultant PGE2 release. Dinoprostone 59-63 interleukin 6 Homo sapiens 21-25 7635234-8 1995 The concentration of IL-6 parallels the reported levels of PGE2, and it is therefore likely that if IL-6 is involved in the mechanism of labour it acts through the effects of the resultant PGE2 release. Dinoprostone 59-63 interleukin 6 Homo sapiens 100-104 7635234-8 1995 The concentration of IL-6 parallels the reported levels of PGE2, and it is therefore likely that if IL-6 is involved in the mechanism of labour it acts through the effects of the resultant PGE2 release. Dinoprostone 189-193 interleukin 6 Homo sapiens 21-25 7635234-8 1995 The concentration of IL-6 parallels the reported levels of PGE2, and it is therefore likely that if IL-6 is involved in the mechanism of labour it acts through the effects of the resultant PGE2 release. Dinoprostone 189-193 interleukin 6 Homo sapiens 100-104 8589268-11 1995 The effects of PGE2 on IL-6 production also varied among TCC. Dinoprostone 15-19 interleukin 6 Homo sapiens 23-27 7549842-0 1995 Dexamethasone and suramin inhibit cell proliferation and interleukin-6-mediated immunoglobulin secretion in human lymphoid and multiple myeloma cell lines. Dexamethasone 0-13 interleukin 6 Homo sapiens 57-70 7549842-5 1995 This study examines growth inhibition and inhibition of IL-6-mediated secretion of immunoglobulin in human lymphoid and myeloma cell lines by dexamethasone and suramin. Dexamethasone 142-155 interleukin 6 Homo sapiens 56-60 7549842-7 1995 IL-6-mediated immunoglobulin secretion is also inhibited by both dexamethasone and suramin in an additive fashion. Dexamethasone 65-78 interleukin 6 Homo sapiens 0-4 7549842-8 1995 Both dexamethasone and suramin induce apoptosis of lymphoid cell lines, and suramin inhibits the binding of IL-6 to its receptor in a multiple myeloma cell line. Dexamethasone 5-18 interleukin 6 Homo sapiens 108-112 7549842-9 1995 These findings suggest that the synergistic growth inhibitory activities of dexamethasone and suramin may be related to induction of apoptosis by both agents and inhibition of IL-6-mediated autocrine growth stimulation and immunoglobulin production. Dexamethasone 76-89 interleukin 6 Homo sapiens 176-180 7482409-8 1995 When combined with either dexamethasone or soluble IL-6 receptor, the IL-6 response was significantly enhanced. Dexamethasone 26-39 interleukin 6 Homo sapiens 70-74 7704910-0 1995 B cell differentiation factor-induced B cell maturation: regulation via reduction in cAMP. Cyclic AMP 85-89 interleukin 6 Homo sapiens 0-29 7704910-3 1995 After exposure of B cells to 446-BCDF, intracellular cAMP concentration started to decrease at 5 min and was significantly lower at 30 min and reached the lowest level at 4 hr. Cyclic AMP 53-57 interleukin 6 Homo sapiens 33-37 7704910-7 1995 Pertussis toxin blocked 446-BCDF-induced B cell differentiation as well, suggesting that 446-BCDF may function by stimulation of a Gi-linked receptor resulting in the inhibition of adenylate cyclase with a consequent reduction in cAMP. Cyclic AMP 230-234 interleukin 6 Homo sapiens 93-97 7704910-7 1995 Pertussis toxin blocked 446-BCDF-induced B cell differentiation as well, suggesting that 446-BCDF may function by stimulation of a Gi-linked receptor resulting in the inhibition of adenylate cyclase with a consequent reduction in cAMP. Cyclic AMP 230-234 interleukin 6 Homo sapiens 28-32 7704910-8 1995 Other cytokines known to promote Ig secretion (IL2 and IL6) also caused a reduction in cAMP, suggesting that this pathway may be generally important in B cell differentiation. Cyclic AMP 87-91 interleukin 6 Homo sapiens 55-58 7536243-6 1995 The suppression of lymphocyte blastogenesis in vitro by cyclosporine or prednisolone was restored by addition of interleukin (IL)-1, IL-2, IL-4, IL-5 or IL-6. Cyclosporine 56-68 interleukin 6 Homo sapiens 153-157 7733868-2 1995 We demonstrated here for the first time that exposure of HeLa cells to a hypotonic medium (30% growth medium and 70% water) prominently induced the binding activity of the heat shock transcription factor (HSF). Water 117-122 interleukin 6 Homo sapiens 172-203 7733868-2 1995 We demonstrated here for the first time that exposure of HeLa cells to a hypotonic medium (30% growth medium and 70% water) prominently induced the binding activity of the heat shock transcription factor (HSF). Water 117-122 interleukin 6 Homo sapiens 205-208 7890061-4 1995 The mean IL-1 beta, IL-6, and TNF-alpha mRNA levels were higher in the late secretory menstrual phase compared with the proliferative early secretory phase of the menstrual cycle both in endometria exposed to the copper IUD and in the control samples. Copper 213-219 interleukin 6 Homo sapiens 20-24 7890061-6 1995 In contrast, the mean IL-6 mRNA level was higher in the copper IUD-exposed endometria than in the control endometria in the proliferative early secretory but not in the late secretory menstrual phase. Copper 56-62 interleukin 6 Homo sapiens 22-26 7615469-5 1995 We observed that the exposure of ASM cells to human recombinant IL-1 beta or IL-6, in all studied concentrations, significantly increased the number of cells as well as [3H]thymidine incorporation into ASM cells. Tritium 170-172 interleukin 6 Homo sapiens 77-81 7790046-9 1995 In fact, the cell cultures treated with hrIL-6 plus hrIL-1 caused a higher release approximately 1.5-4-fold of SAA protein than the cells treated with IL-6 plus PGE2 5 microM or IL-1 + PGE2 5 microM, respectively. Dinoprostone 185-189 interleukin 6 Homo sapiens 42-46 7782982-7 1995 Total RNA from steroid-treated hGF was probed for IL-6 mRNA. Steroids 15-22 interleukin 6 Homo sapiens 50-54 7789055-9 1995 These results in human "in vivo" confirm that ovarian steroids play an important role in regulating the production of IL1 and IL6 which could regulate bone resorption. Steroids 54-62 interleukin 6 Homo sapiens 126-129 7745500-5 1995 Taken together, these results strongly suggest that mesangial cell proliferation and increased production of immune/chemical mediators and superoxide anion can be directly induced by IL-1 plus IL-6. Superoxides 139-155 interleukin 6 Homo sapiens 193-197 7751029-5 1995 Further, our data indicate that PGE2 suppressed the gene activation of IL-6 following LPS stimulation, but neither CT nor 8-bromo-cAMP had an effect. Dinoprostone 32-36 interleukin 6 Homo sapiens 71-75 7540349-5 1995 Likewise, NMMA inhibited interleukin-6 secretion, independently of its effect on cell number. omega-N-Methylarginine 10-14 interleukin 6 Homo sapiens 25-38 7884317-6 1995 The anti-inflammatory agent, dexamethasone, was the most potent agent in controlling the SE-mediated effects as evidenced by inhibited T cell proliferation (55%) and reduced levels of IL-1, IL-6, and IFN gamma (60% to 100%) and TNF alpha (50%). Dexamethasone 29-42 interleukin 6 Homo sapiens 190-194 7757467-0 1995 Cerebellar granule neurons develop elevated calcium responses when treated with interleukin-6 in culture. Calcium 44-51 interleukin 6 Homo sapiens 80-93 7861550-7 1995 Antibodies to IL-6 caused a significant (p = 0.043) inhibition of tumor growth and decreased serum calcium concentrations compared with control animals. Calcium 99-106 interleukin 6 Homo sapiens 14-18 7861551-2 1995 Since steroids are known to inhibit IL-6 gene expression, we investigated their effects on the growth of renal cell carcinoma. Steroids 6-14 interleukin 6 Homo sapiens 36-40 7861551-10 1995 A dose-dependent increase in mRNA expression of gp130, the transducer of IL-6 signal, was induced by dexamethasone and progesterone in 2 and 1 of the 4 cell lines, respectively. Dexamethasone 101-114 interleukin 6 Homo sapiens 73-77 7861551-10 1995 A dose-dependent increase in mRNA expression of gp130, the transducer of IL-6 signal, was induced by dexamethasone and progesterone in 2 and 1 of the 4 cell lines, respectively. Progesterone 119-131 interleukin 6 Homo sapiens 73-77 7861551-12 1995 Dexamethasone may be useful, not only for palliation of paraneoplastic syndrome caused by overproduction of IL-6, but also for inhibition of growth of renal cell carcinomas. Dexamethasone 0-13 interleukin 6 Homo sapiens 108-112 7538612-5 1995 IL-6 had no direct stimulatory effect on its own, but synergized with IL-1 to induce an increased production of C3 in the culture supernatant and its relative amount was confirmed by SDS-PAGE and immunoblot. Sodium Dodecyl Sulfate 183-186 interleukin 6 Homo sapiens 0-4 7879350-7 1995 A direct comparison of the high and low serum IL-6 groups show that elevated IL-6 levels are strongly correlated with objective measures of morbidity: decreased hematocrit, hemoglobin, and serum cholesterol, and increased white blood cell count and serum lactate dehydrogenase levels all in the absence of clinical infection. Cholesterol 195-206 interleukin 6 Homo sapiens 77-81 7531395-6 1995 In 3 hr high dose-IL-6 platelet incubations, a significant 18% (N = 8; P < 0.001) decrease in platelet ATP was parallelled by a significant 40% increase (N = 8; P < 0.014) in plasma ATP in the same specimens. Adenosine Triphosphate 106-109 interleukin 6 Homo sapiens 18-22 7533107-0 1995 Interleukin-6-induced serine phosphorylation of transcription factor APRF: evidence for a role in interleukin-6 target gene induction. Serine 22-28 interleukin 6 Homo sapiens 0-13 7533107-0 1995 Interleukin-6-induced serine phosphorylation of transcription factor APRF: evidence for a role in interleukin-6 target gene induction. Serine 22-28 interleukin 6 Homo sapiens 98-111 7533107-1 1995 The cytokine interleukin-6 (IL-6) rapidly activates a latent cytoplasmic transcription factor, acute-phase response factor (APRF), by tyrosine phosphorylation. Tyrosine 134-142 interleukin 6 Homo sapiens 13-26 7533107-1 1995 The cytokine interleukin-6 (IL-6) rapidly activates a latent cytoplasmic transcription factor, acute-phase response factor (APRF), by tyrosine phosphorylation. Tyrosine 134-142 interleukin 6 Homo sapiens 28-32 7533107-4 1995 We now show that IL-6 triggers a delayed phosphorylation of APRF at serine resudues which can be reversed in vitro by protein phosphatase 2A and is also inhibited by H7. Serine 68-74 interleukin 6 Homo sapiens 17-21 7533107-5 1995 Therefore, APRF serine phosphorylation is likely to represent a crucial event in IL-6 signal transduction leading to target gene induction. Serine 16-22 interleukin 6 Homo sapiens 81-85 7816067-4 1995 The production of interleukin-6 by stromal osteoblastic cells, as well as the responsiveness of bone marrow cells to cytokines such as interleukin-6 and interleukin-11, is regulated by sex steroids. Steroids 189-197 interleukin 6 Homo sapiens 18-31 7816067-4 1995 The production of interleukin-6 by stromal osteoblastic cells, as well as the responsiveness of bone marrow cells to cytokines such as interleukin-6 and interleukin-11, is regulated by sex steroids. Steroids 189-197 interleukin 6 Homo sapiens 135-148 7877973-3 1995 PDGF-induced transcription, translation, and secretion of IL-6 were diminished in the presence of IL-6 antisense oligonucleotides. Oligonucleotides 113-129 interleukin 6 Homo sapiens 58-62 7877973-3 1995 PDGF-induced transcription, translation, and secretion of IL-6 were diminished in the presence of IL-6 antisense oligonucleotides. Oligonucleotides 113-129 interleukin 6 Homo sapiens 98-102 7877973-4 1995 While neutralizing anti-IL-6 antibodies failed to affect the growth factor-dependent cell proliferation, IL-6 antisense oligonucleotides inhibited cell division. Oligonucleotides 120-136 interleukin 6 Homo sapiens 105-109 7877973-5 1995 In addition, IL-6 antisense oligonucleotides abolished PDGF-induced transcription of the genes coding for the cell division cycle 2-related protein (CDC2) and proliferating cell nuclear antigen (PCNA), both of which are regulated in a cell cycle-dependent manner. Oligonucleotides 28-44 interleukin 6 Homo sapiens 13-17 7531395-5 1995 Significant increases in platelet ATP levels were observed in both 1 min and 1 hr high dose and low dose IL-6 platelet incubations. Adenosine Triphosphate 34-37 interleukin 6 Homo sapiens 105-109 7531395-6 1995 In 3 hr high dose-IL-6 platelet incubations, a significant 18% (N = 8; P < 0.001) decrease in platelet ATP was parallelled by a significant 40% increase (N = 8; P < 0.014) in plasma ATP in the same specimens. Adenosine Triphosphate 188-191 interleukin 6 Homo sapiens 18-22 7851022-13 1995 Stimulation with phytohaemagglutinin (PHA) and phorbol myristate acetate (PMA) induced most TCC to produce higher amounts of TNF-alpha, IL-2 and IL-6. Tetradecanoylphorbol Acetate 47-72 interleukin 6 Homo sapiens 145-149 7834629-16 1995 This study demonstrates that treatment of RCC cells with CDDP in combination with anti-IL-6 mAb or anti-IL-6R mAb can overcome their CDDP-resistance and that the down-regulation of glutathione S-transferase pi expression by anti-IL-6 mAb or anti-IL-6R mAb might play a role in the enhanced cytotoxicity obtained. Cisplatin 57-61 interleukin 6 Homo sapiens 87-91 7834629-16 1995 This study demonstrates that treatment of RCC cells with CDDP in combination with anti-IL-6 mAb or anti-IL-6R mAb can overcome their CDDP-resistance and that the down-regulation of glutathione S-transferase pi expression by anti-IL-6 mAb or anti-IL-6R mAb might play a role in the enhanced cytotoxicity obtained. Cisplatin 133-137 interleukin 6 Homo sapiens 87-91 7834629-16 1995 This study demonstrates that treatment of RCC cells with CDDP in combination with anti-IL-6 mAb or anti-IL-6R mAb can overcome their CDDP-resistance and that the down-regulation of glutathione S-transferase pi expression by anti-IL-6 mAb or anti-IL-6R mAb might play a role in the enhanced cytotoxicity obtained. Cisplatin 133-137 interleukin 6 Homo sapiens 104-108 7702403-0 1995 Effect of cyclosporin A on interleukin-6 and soluble interleukin-2 receptor in patients with rheumatoid arthritis. Cyclosporine 10-23 interleukin 6 Homo sapiens 27-40 7702403-1 1995 OBJECTIVE: To investigate the effect of cyclosporin A (CyA) therapy on circulating concentrations of interleukin-6 (IL-6) and soluble interleukin-2 receptor (sIL-2R) in patients with rheumatoid arthritis (RA). Cyclosporine 40-53 interleukin 6 Homo sapiens 101-114 7702403-1 1995 OBJECTIVE: To investigate the effect of cyclosporin A (CyA) therapy on circulating concentrations of interleukin-6 (IL-6) and soluble interleukin-2 receptor (sIL-2R) in patients with rheumatoid arthritis (RA). Cyclosporine 40-53 interleukin 6 Homo sapiens 116-120 7702403-1 1995 OBJECTIVE: To investigate the effect of cyclosporin A (CyA) therapy on circulating concentrations of interleukin-6 (IL-6) and soluble interleukin-2 receptor (sIL-2R) in patients with rheumatoid arthritis (RA). Cyclosporine 55-58 interleukin 6 Homo sapiens 101-114 7702403-1 1995 OBJECTIVE: To investigate the effect of cyclosporin A (CyA) therapy on circulating concentrations of interleukin-6 (IL-6) and soluble interleukin-2 receptor (sIL-2R) in patients with rheumatoid arthritis (RA). Cyclosporine 55-58 interleukin 6 Homo sapiens 116-120 7834629-0 1995 Sensitization of human renal cell carcinoma cells to cis-diamminedichloroplatinum(II) by anti-interleukin 6 monoclonal antibody or anti-interleukin 6 receptor monoclonal antibody. Cisplatin 53-81 interleukin 6 Homo sapiens 94-107 7834629-7 1995 Treatment of Caki-1 cells with anti-IL-6 mAb or anti-IL-6R mAb in combination with cis-diamminedichloroplatinum(II) (CDDP) or mitomycin C overcame their resistance to CDDP or mitomycin C. Cisplatin 167-171 interleukin 6 Homo sapiens 36-40 7851022-13 1995 Stimulation with phytohaemagglutinin (PHA) and phorbol myristate acetate (PMA) induced most TCC to produce higher amounts of TNF-alpha, IL-2 and IL-6. Tetradecanoylphorbol Acetate 74-77 interleukin 6 Homo sapiens 145-149 7657404-6 1995 The inhibiting effect of sex steroids on IL-6 production is mediated by their respective receptors and is exerted indirectly on the transcriptional activity of the proximal 225 bp sequence of the IL-6 gene promoter. Steroids 29-37 interleukin 6 Homo sapiens 41-45 7539633-9 1995 CONCLUSION: Supplementation of an enteral diet with arginine, RNA and omega-3 fatty acids can modulate the acute phase reaction as indicated by the reduction in concentrations of TNF-alpha and IL-6 in the group fed the supplemented diet. Arginine 52-60 interleukin 6 Homo sapiens 193-197 7657404-6 1995 The inhibiting effect of sex steroids on IL-6 production is mediated by their respective receptors and is exerted indirectly on the transcriptional activity of the proximal 225 bp sequence of the IL-6 gene promoter. Steroids 29-37 interleukin 6 Homo sapiens 196-200 7836930-4 1995 PGE2 almost completely inhibited lipopolysaccharide induced IL-12 production, whereas IL-6 production was only partially inhibited by PGE2. Dinoprostone 134-138 interleukin 6 Homo sapiens 86-90 7759567-8 1995 This inhibitory activity of tepoxalin was further illustrated by its suppression of NF kappa B regulated genes such as IL-6 in PMA stimulated human PBL and c-myc in IL-2 dependent T cell lines. tepoxalin 28-37 interleukin 6 Homo sapiens 119-123 7770069-4 1995 In order to understand the mechanisms by which IL-1 inhibits IL-6-stimulated fibrinogen transcription and translation, and since IL-1 is believed to act through PGE2 stimulation, we have studied the influence of PGE2 in IL-6 or IL-1, alone and in combination, on Fg mRNA expression (by Northern blot analysis) and the influence of PGE2, indomethacin, and arachidonic acid on Fg secretion. Dinoprostone 212-216 interleukin 6 Homo sapiens 220-224 7861762-7 1995 At a concentration of 1000 ng/ml, IL-6 increased neutrophil phagocytosis of opsonized bacteria (826 +/- 255 x 10(3) MESF vs 552 +/- 103 MESF, P < 0.05) and also increased neutrophil superoxide anion generation (18.41 +/- 1.86 vs 12.6 nmol O2-/10(6) PMN/10 min, P < 0.05). Superoxides 185-201 interleukin 6 Homo sapiens 34-38 7861762-7 1995 At a concentration of 1000 ng/ml, IL-6 increased neutrophil phagocytosis of opsonized bacteria (826 +/- 255 x 10(3) MESF vs 552 +/- 103 MESF, P < 0.05) and also increased neutrophil superoxide anion generation (18.41 +/- 1.86 vs 12.6 nmol O2-/10(6) PMN/10 min, P < 0.05). Superoxides 242-244 interleukin 6 Homo sapiens 34-38 7861762-10 1995 Combining IL-6 with TNF-alpha at doses of 100 ng/ml and 100 U/ml, respectively, neutrophil phagocytosis (221 +/- 455 MESF vs 552 +/- 103 MESF) and superoxide generation (23.18 +/- 1.86 vs 12.6 nmol O2-/10(6) PMN/10 min) were significantly (P < 0.05) increased above control by an amount similar to that seen with 1000 U/ml TNF-alpha alone. Superoxides 198-200 interleukin 6 Homo sapiens 10-14 7770069-4 1995 In order to understand the mechanisms by which IL-1 inhibits IL-6-stimulated fibrinogen transcription and translation, and since IL-1 is believed to act through PGE2 stimulation, we have studied the influence of PGE2 in IL-6 or IL-1, alone and in combination, on Fg mRNA expression (by Northern blot analysis) and the influence of PGE2, indomethacin, and arachidonic acid on Fg secretion. Dinoprostone 212-216 interleukin 6 Homo sapiens 220-224 7851440-0 1995 Structure, stability and biological properties of a N-terminally truncated form of recombinant human interleukin-6 containing a single disulfide bond. Disulfides 135-144 interleukin 6 Homo sapiens 101-114 7695204-1 1995 To clarify the mechanism that causes elevation of plasma fibrinogen levels in diabetes, we examined the effect of high concentration of glucose and/or advanced glycosylation end products (AGEs) on the production of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) by human monocytes. Glucose 136-143 interleukin 6 Homo sapiens 215-228 7695204-4 1995 IL-6 and TNF-alpha levels of culture supernatants incubated with 22 mM or 33 mM glucose showed considerable increase over basal levels incubated with 11 mM glucose, whereas those levels incubated with high concentration of mannitol showed no increase. Glucose 80-87 interleukin 6 Homo sapiens 0-4 7695204-4 1995 IL-6 and TNF-alpha levels of culture supernatants incubated with 22 mM or 33 mM glucose showed considerable increase over basal levels incubated with 11 mM glucose, whereas those levels incubated with high concentration of mannitol showed no increase. Glucose 156-163 interleukin 6 Homo sapiens 0-4 7695204-6 1995 Our serial observation with treatment for lowering glucose levels showed that the diabetics with decreasing plasma fibrinogen levels also showed decrease in plasma IL-6 levels. Glucose 51-58 interleukin 6 Homo sapiens 164-168 7695204-7 1995 In this study, we revealed the effect of glucose and AGEs on the production of IL-6 or TNF-alpha by human monocytes. Glucose 41-48 interleukin 6 Homo sapiens 79-83 7851440-1 1995 A mutant species of the 185-residue chain of human interleukin-6 lacking 22-residues at its N-terminus and with a Cys-->Ser substitution at positions 45 and 51 was produced in Escherichia coli. Cysteine 114-117 interleukin 6 Homo sapiens 51-64 7851440-1 1995 A mutant species of the 185-residue chain of human interleukin-6 lacking 22-residues at its N-terminus and with a Cys-->Ser substitution at positions 45 and 51 was produced in Escherichia coli. Serine 123-126 interleukin 6 Homo sapiens 51-64 7851440-2 1995 The 163-residue protein des-(A1-S22)-[C45S, C51S]interleukin-6, containing a single disulfide bridge, formed inclusion bodies. Disulfides 84-93 interleukin 6 Homo sapiens 49-62 7851440-7 1995 The urea-induced unfolding of mutant interleukin-6, monitored by circular dichroic measurements in the far-ultraviolet region, occurs as a highly cooperative process with a midpoint of denaturation at 5.5 M urea. Urea 4-8 interleukin 6 Homo sapiens 37-50 7851440-7 1995 The urea-induced unfolding of mutant interleukin-6, monitored by circular dichroic measurements in the far-ultraviolet region, occurs as a highly cooperative process with a midpoint of denaturation at 5.5 M urea. Urea 207-211 interleukin 6 Homo sapiens 37-50 7851440-8 1995 The data of the reversible unfolding of mutant interleukin-6 mediated by urea were used to calculate a value of 20.9 +/- 0.4 kJ.mol-1 for the thermodynamic stability of the protein at 25 degrees C in the absence of denaturant. Urea 73-77 interleukin 6 Homo sapiens 47-60 7578871-1 1995 We describe the distribution of interleukin-6 and interleukin-1 alpha in thyroid tissues obtained from patients with autoimmune diseases or neoplastic thyroid disorders employing immunohistochemistry in sections from paraffin embedded tissue blocks. Paraffin 217-225 interleukin 6 Homo sapiens 32-45 7599390-0 1995 Intralesional steroid-therapy-induced reduction of plasma interleukin-6 and improvement of cutaneous plasmacytosis. Steroids 14-21 interleukin 6 Homo sapiens 58-71 7833269-0 1995 Hypercalcaemia and increased serum interleukin-6 levels induced by all-trans retinoic acid in patients with multiple myeloma. Tretinoin 77-90 interleukin 6 Homo sapiens 35-48 7833269-3 1995 We report that three out of six treated patients developed severe hypercalcaemia following administration of ATRA, which was accompanied by a significant rise in serum IL-6 levels. Tretinoin 109-113 interleukin 6 Homo sapiens 168-172 7599390-3 1995 Intralesional steroid reduced IL-6 production by peripheral blood mononuclear cells, while neither PUVA therapy nor intralesional recombinant interferon-gamma resulted in a benefit and plasma IL-6 levels did not decrease. Steroids 14-21 interleukin 6 Homo sapiens 30-34 22823242-5 1995 Interleukin-6 was found to be elevated in the aqueous humor of two patients (20%) with CU, but in none of the controls. Copper 87-89 interleukin 6 Homo sapiens 0-13 7734430-10 1995 The correlation between TNF-alpha and PGE2 levels was .5 between IL-6 and PGE2 was .6, and between IL-6 and TNF-alpha was .77. Dinoprostone 38-42 interleukin 6 Homo sapiens 65-69 7734430-10 1995 The correlation between TNF-alpha and PGE2 levels was .5 between IL-6 and PGE2 was .6, and between IL-6 and TNF-alpha was .77. Dinoprostone 74-78 interleukin 6 Homo sapiens 65-69 7792027-1 1995 We examined in vivo the release of tumour necrosis factor alpha (TNF alpha) and interleukin 6 (IL-6) by uraemic monocytes upon stimulation with endotoxin-contaminated bicarbonate concentrate. Bicarbonates 167-178 interleukin 6 Homo sapiens 95-99 7731159-0 1995 Effect of lactate-buffered peritoneal dialysis fluids on human peritoneal mesothelial cell interleukin-6 and prostaglandin synthesis. Lactic Acid 10-17 interleukin 6 Homo sapiens 91-104 7731159-2 1995 Exposure of HPMC to PDF pH 5.2 resulted in a time-dependent increase in cell cytotoxicity [as assessed by lactate dehydrogenase (LDH) release] and concomitant inhibition of constitutive and IL-1 beta stimulated IL-6 and 6-keto-PGF1 alpha synthesis. hydroxypropylmethylcellulose-lactose matrix 12-16 interleukin 6 Homo sapiens 211-215 7566325-11 1995 A disturbed profile synthesis of cytokines which induce differentiation and proliferation of the osteoclasts and which modulate the osteoblastic proliferation and function (IL-1, IL-6, TNF-alpha, GM-CSF...) may play a role in the bone loss of calcium stone formers but further studies are necessary to precise its transient or permanent involvement in their bone disease. Calcium 243-250 interleukin 6 Homo sapiens 179-183 7749254-2 1995 The fall in serum iron and zinc, and rise in serum copper, are brought about by changes in the concentration of specific tissue proteins controlled by cytokines, especially interleukin 1, tumor necrosis factor, and interleukin 6. Copper 51-57 interleukin 6 Homo sapiens 215-228 7502507-4 1995 Liberation of cytokines (IL-1, IL-6, IL-8) stimulates prostanoid synthesis in the decidua and amnion, as well as migration of granulocytes into the cervix. Prostaglandins 54-64 interleukin 6 Homo sapiens 31-35 7527666-9 1994 (2) Hydrocortisone counteracted the stimulatory effect of recombinant human cytokines (interleukin-3, interleukin-6, and steel factor) in assays performed on MS-5 but not on human marrow feeders. Hydrocortisone 4-18 interleukin 6 Homo sapiens 102-115 7708925-6 1995 It is hypothesized that increased monocytic production of interleukins (Il-1 beta and Il-6) in severe depression may constitute key phenomena underlying the various aspects of the immune and "acute" phase response, while contributing to hypothalamic-pituitary-adrenal-axis hyperactivity, disorders in serotonin metabolism, and to the vegetative symptoms (i.e. the sickness behavior) of severe depression. Serotonin 301-310 interleukin 6 Homo sapiens 86-90 7998663-7 1994 In patients with systemic sclerosis with a shorter disease duration, greater spontaneous as well as collagen- and heparin-stimulated IL-6 production was observed, whereas decreased IL-6 levels were noted with longer disease duration (> 21 years). Heparin 114-121 interleukin 6 Homo sapiens 133-137 7810656-5 1994 Hepatocytes cultured for 20 h in media containing IL-6 exhibited a dose-dependent noncompetitive inhibition of [3H]taurocholate uptake, which was maximal at an IL-6 dose of 100 U/ml. Tritium 112-114 interleukin 6 Homo sapiens 50-54 7810656-5 1994 Hepatocytes cultured for 20 h in media containing IL-6 exhibited a dose-dependent noncompetitive inhibition of [3H]taurocholate uptake, which was maximal at an IL-6 dose of 100 U/ml. Tritium 112-114 interleukin 6 Homo sapiens 160-164 7810656-11 1994 The inhibition of Na(+)-K(+)-ATPase activity induced by IL-6 provides a putative mechanism for the observed inhibition of sodium-dependent taurocholate uptake. Sodium 122-128 interleukin 6 Homo sapiens 56-60 7988196-16 1994 CONCLUSIONS: We conclude that asthmatics exposed to ozone develop a significant BALF neutrophilia and increased levels of the cytokines, IL-8 and IL-6. Ozone 52-57 interleukin 6 Homo sapiens 146-150 7810656-12 1994 Since modulation of bile salt transport and Na(+)-K(+)-ATPase activity occurred at IL-6 concentrations comparable to the serum levels observed in patients with severe inflammatory states, these findings have potential pathophysiological relevance for the cholestasis of sepsis and other inflammatory disorders. Bile Acids and Salts 20-29 interleukin 6 Homo sapiens 83-87 7949151-4 1994 PBMC, after infection with EBV and CsA treatment, demonstrated increased interleukin-6 (IL-6) activity in the culture supernatant. Cyclosporine 35-38 interleukin 6 Homo sapiens 88-92 7949151-7 1994 Expression of IL-6 in T cells appears to be due mainly to CsA. Cyclosporine 58-61 interleukin 6 Homo sapiens 14-18 7949151-10 1994 IL-6, which is induced by CsA in PBMC, was also capable of inducing the lytic viral cycle in several EBV-immortalized cells. Cyclosporine 26-29 interleukin 6 Homo sapiens 0-4 7949151-11 1994 CsA, in promoting both increased numbers of lytic EBV B cells and an EBV paracrine factor, IL-6, within the microenvironment of EBV B cell:T cell and EBV B cell:monocyte interactions, may result in increased EBV B-cell immortalization and ultimately lead to the promotion of B-cell lymphomas in immunosuppressed patients. Cyclosporine 0-3 interleukin 6 Homo sapiens 91-95 7731274-6 1994 A significant increase in IL-6 production after mitogen stimulation with tetradecanoylphorbol acetate (TPA) and phytohemagglutinin (PHA) after 24 and 48 h of culture, as well as a greater induced TNF alpha production after 48 h of incubation with the same mitogens, was found in the anorectic patients as compared with the elderly controls. Tetradecanoylphorbol Acetate 73-101 interleukin 6 Homo sapiens 26-30 7628063-0 1994 Endocrine and carbohydrate responses to interleukin-6 in vivo. Carbohydrates 14-26 interleukin 6 Homo sapiens 40-53 7628063-1 1994 The role of interleukin-6 (IL-6) in carbohydrate metabolism beyond its inhibition of hepatic phosphoenolpyruvate carboxykinase has not been widely pursued. Carbohydrates 36-48 interleukin 6 Homo sapiens 12-25 7628063-1 1994 The role of interleukin-6 (IL-6) in carbohydrate metabolism beyond its inhibition of hepatic phosphoenolpyruvate carboxykinase has not been widely pursued. Carbohydrates 36-48 interleukin 6 Homo sapiens 27-31 7843804-7 1994 IL-6 inhibited superoxide production by chondrocytes both in IL-1 beta-stimulated or unstimulated conditions. Superoxides 15-25 interleukin 6 Homo sapiens 0-4 7843804-9 1994 IL-6 inhibited superoxide production in chondrocytes and thus inhibited cartilage matrix degradation. Superoxides 15-25 interleukin 6 Homo sapiens 0-4 7877083-7 1994 These data indicate that IL-6 production by HGF is up-regulated by specific cytokines, IL-1 beta and TNF-alpha, and suggest that this production may be partially down-regulated by endogenous and exogenous PGE2 at the post-transcriptional level. Dinoprostone 205-209 interleukin 6 Homo sapiens 25-29 7528862-6 1994 In contrast, an IL-6 antisense oligonucleotide had an opposite effect. Oligonucleotides 31-46 interleukin 6 Homo sapiens 16-20 7696923-4 1994 In the patient treated with cyclosporin A alone, decreasing serum IL-6 and beta-2-microglobulin levels fell as the clinical response evolved. Cyclosporine 28-41 interleukin 6 Homo sapiens 66-70 7538847-10 1994 For human IL-6, it would appear that interactions between residues Ala-180, Leu-181, and Met-184 and residues in the N-terminal region may be critical for maintaining the structure of the molecule; replacement of these residues with the corresponding 3 residues in mouse IL-6 correlated with a significant loss of alpha-helical content and a 200-fold reduction in activity in the mouse bioassay. Alanine 67-70 interleukin 6 Homo sapiens 10-14 7628063-4 1994 IL-6 produced a transient increase in plasma glucagon that was mirrored by elevated plasma glucose and a depletion of hepatic glycogen. Glucose 91-98 interleukin 6 Homo sapiens 0-4 7628063-7 1994 The results demonstrate that IL-6, acting directly on peripheral organs and/or through the central nervous system (CNS) can alter the hormonal and carbohydrate milieu. Carbohydrates 147-159 interleukin 6 Homo sapiens 29-33 7877083-0 1994 Prostaglandin E2 inhibits interleukin-6 release but not its transcription in human gingival fibroblasts stimulated with interleukin-1 beta or tumor necrosis factor-alpha. Dinoprostone 0-16 interleukin 6 Homo sapiens 26-39 7877083-2 1994 The purpose of this study was to examine whether prostaglandin E2 (PGE2), which is produced in abundance from HGF after stimulation with interleukin (IL)-1 beta or tumor necrosis factor-alpha (TNF-alpha), could regulate IL-6 production by HGF. Dinoprostone 49-65 interleukin 6 Homo sapiens 220-224 7877083-2 1994 The purpose of this study was to examine whether prostaglandin E2 (PGE2), which is produced in abundance from HGF after stimulation with interleukin (IL)-1 beta or tumor necrosis factor-alpha (TNF-alpha), could regulate IL-6 production by HGF. Dinoprostone 67-71 interleukin 6 Homo sapiens 220-224 7877083-4 1994 IL-6 secretion from either IL-1 beta- or TNF-alpha-stimulated HGF was enhanced by the inhibition of PGE2 synthesis with indomethacin. Dinoprostone 100-104 interleukin 6 Homo sapiens 0-4 7877083-5 1994 Furthermore, the addition of PGE2 inhibited IL-6 secretion from these cells. Dinoprostone 29-33 interleukin 6 Homo sapiens 44-48 7731274-6 1994 A significant increase in IL-6 production after mitogen stimulation with tetradecanoylphorbol acetate (TPA) and phytohemagglutinin (PHA) after 24 and 48 h of culture, as well as a greater induced TNF alpha production after 48 h of incubation with the same mitogens, was found in the anorectic patients as compared with the elderly controls. Tetradecanoylphorbol Acetate 103-106 interleukin 6 Homo sapiens 26-30 7979944-9 1994 Interleukin 6 (10 ng/mL) combined with a nonpriming concentration of PAF (0.1 ng/mL) primed PMNs for superoxide production over a range of incubation times. Superoxides 101-111 interleukin 6 Homo sapiens 0-13 7963520-3 1994 IL-6 also induced tyrosine phosphorylation of the signaling transducing subunit of the IL-6R in AF10 cells, along with tyrosine phosphorylation of the gp130-associated tyrosine protein kinase JAK1 and the adaptor molecule p52shc. Tyrosine 18-26 interleukin 6 Homo sapiens 0-4 7963520-3 1994 IL-6 also induced tyrosine phosphorylation of the signaling transducing subunit of the IL-6R in AF10 cells, along with tyrosine phosphorylation of the gp130-associated tyrosine protein kinase JAK1 and the adaptor molecule p52shc. Tyrosine 119-127 interleukin 6 Homo sapiens 0-4 7963520-4 1994 Although induction of tyrosine phosphorylation and activation of MAP kinase by IL-6 in a differentiation-responsive B cell line, SKW 6.4, were below the limits of detection, the phorbol ester PMA did activate Raf-1, MEK-1, and MAP kinase without inducing the phosphorylation of gp130, JAKs, or p52shc. Tyrosine 22-30 interleukin 6 Homo sapiens 79-83 7695840-4 1994 Retinoic acid increased the effect of IL-6 on alpha-1-antichymotrypsin (ACT) and fibrinogen (FBG) on the level of both proteins and mRNAs. Tretinoin 0-13 interleukin 6 Homo sapiens 38-42 7695840-6 1994 Dexamethasone had small enhancing effect on the action of IL-6. Dexamethasone 0-13 interleukin 6 Homo sapiens 58-62 7987859-8 1994 Hypercalcemic subjects with increased IL-6 had higher urinary Ca/creatinine levels than patients with normal IL-6 levels (P < 0.005) but this was not the case in normocalcemic subjects. Creatinine 65-75 interleukin 6 Homo sapiens 38-42 7949175-0 1994 Inhibitory effect of all-trans retinoic acid on the growth of freshly isolated myeloma cells via interference with interleukin-6 signal transduction. Tretinoin 31-44 interleukin 6 Homo sapiens 115-128 7949175-4 1994 Furthermore, ATRA inhibited the production of IL-6 from both myeloma cells and marrow stromal cells, and recombinant IL-6 (rIL-6) could partially recover the myeloma cell growth that had been inhibited by ATRA. Tretinoin 13-17 interleukin 6 Homo sapiens 46-50 7949175-4 1994 Furthermore, ATRA inhibited the production of IL-6 from both myeloma cells and marrow stromal cells, and recombinant IL-6 (rIL-6) could partially recover the myeloma cell growth that had been inhibited by ATRA. Tretinoin 205-209 interleukin 6 Homo sapiens 117-121 7949175-5 1994 These data suggest that ATRA may inhibit the proliferation of myeloma cells both by the downregulation of IL-6R and gp130 expression on myeloma cells and by the inhibition of IL-6 production from myeloma and stromal cells. Tretinoin 24-28 interleukin 6 Homo sapiens 106-110 7949178-0 1994 Interleukin-6 prevents dexamethasone-induced myeloma cell death. Dexamethasone 23-36 interleukin 6 Homo sapiens 0-13 7949178-3 1994 Dexamethasone (Dex) concentrations of 10(-7) to 10(-6) mol/L inhibited IL-6 gene expression in three of four cell lines studied, whereas the higher concentration of the hormone inhibited also IL-6R gene expression. Dexamethasone 0-13 interleukin 6 Homo sapiens 71-75 7949178-3 1994 Dexamethasone (Dex) concentrations of 10(-7) to 10(-6) mol/L inhibited IL-6 gene expression in three of four cell lines studied, whereas the higher concentration of the hormone inhibited also IL-6R gene expression. Dexamethasone 0-3 interleukin 6 Homo sapiens 71-75 7949178-5 1994 Dex treatment resulted in killing of sensitive cells associated with DNA fragmentation, which could be reversed by concomitant treatment with IL-6. Dexamethasone 0-3 interleukin 6 Homo sapiens 142-146 7949178-6 1994 The reversal of Dex-mediated effects by IL-6 did not result from an inhibition of GR function as measured by receptor nuclear translocation or Dex-regulated reporter gene function. Dexamethasone 16-19 interleukin 6 Homo sapiens 40-44 7949178-7 1994 These results indicate that blockage of the IL-6 signaling pathway is essential for effective myeloma cell kill by Dex. Dexamethasone 115-118 interleukin 6 Homo sapiens 44-48 7865515-7 1994 Activation of six additional isolates of lymphocytes with phorbol myristate acetate before exposure to human aortic endothelial cells resulted in an increase in human aortic endothelial cell-derived interleukin-6 bioactivity regardless of whether the cells were in direct contact with the human aortic endothelial cells, but the interleukin-6 level increase was approximately twofold higher in those cocultures where there was direct contact. Tetradecanoylphorbol Acetate 58-83 interleukin 6 Homo sapiens 199-212 7962348-5 1994 IL-6 messenger ribonucleic acid occurred in the inner zone of the adrenal cortex in anti-17 alpha-hydroxylase-positive steroid cells. Steroids 119-126 interleukin 6 Homo sapiens 0-4 7955543-0 1994 Histamine induces IL-6 production by human endothelial cells. Histamine 0-9 interleukin 6 Homo sapiens 18-22 7955543-5 1994 In addition, histamine increased in a dose- (from 10(-5) to 10(-3) M) and time- (from 4 h to 24 h) dependent fashion the IL-6 synthesis by endothelial cells. Histamine 13-22 interleukin 6 Homo sapiens 121-125 7955543-6 1994 Tumour necrosis factor-alpha (TNF-alpha)-induced IL-6 production was also potentiated in a dose-dependent manner by histamine, without modification of the time course of IL-6 secretion. Histamine 116-125 interleukin 6 Homo sapiens 49-53 7955543-7 1994 Moreover, this increase of IL-6 production induced by histamine was inhibited in a dose-dependent manner by H1 and H2 histamine receptor antagonists (50% inhibition of IL-6 production at 5 x 10(-4) M and 4 x 10(-5) M, respectively). Histamine 54-63 interleukin 6 Homo sapiens 27-31 7955543-7 1994 Moreover, this increase of IL-6 production induced by histamine was inhibited in a dose-dependent manner by H1 and H2 histamine receptor antagonists (50% inhibition of IL-6 production at 5 x 10(-4) M and 4 x 10(-5) M, respectively). Histamine 54-63 interleukin 6 Homo sapiens 168-172 7955543-8 1994 So, histamine induces, besides already well known effects, a late stimulation of endothelial cells, i.e. the production of IL-6. Histamine 4-13 interleukin 6 Homo sapiens 123-127 7962338-1 1994 Increased serum interleukin-6 (IL-6) concentrations have recently been reported in patients with subacute thyroiditis and in some patients with amiodarone-induced thyrotoxicosis, possibly because of cytokine release from damaged thyroid cells. Amiodarone 144-154 interleukin 6 Homo sapiens 16-29 7962338-1 1994 Increased serum interleukin-6 (IL-6) concentrations have recently been reported in patients with subacute thyroiditis and in some patients with amiodarone-induced thyrotoxicosis, possibly because of cytokine release from damaged thyroid cells. Amiodarone 144-154 interleukin 6 Homo sapiens 31-35 7962338-2 1994 In this study, serum IL-6 levels were determined by an enzyme-linked immunosorbent assay method in 18 patients given percutaneous intranodular ethanol injection (PIEI) for autonomously functioning thyroid nodule, 12 patients treated with radioactive iodine (RAI) for Graves" disease or toxic adenoma, and 23 patients submitted to fine needle aspiration (FNA) for nonfunctioning thyroid nodules. Ethanol 143-150 interleukin 6 Homo sapiens 21-25 7865515-7 1994 Activation of six additional isolates of lymphocytes with phorbol myristate acetate before exposure to human aortic endothelial cells resulted in an increase in human aortic endothelial cell-derived interleukin-6 bioactivity regardless of whether the cells were in direct contact with the human aortic endothelial cells, but the interleukin-6 level increase was approximately twofold higher in those cocultures where there was direct contact. Tetradecanoylphorbol Acetate 58-83 interleukin 6 Homo sapiens 329-342 7967742-7 1994 The relationship between Rb protein and IL-6 expression was further studied by suppressing Rb protein expression with antisense oligonucleotides. Oligonucleotides 128-144 interleukin 6 Homo sapiens 40-44 7930619-4 1994 In this study, we demonstrate that adenosine inhibits the production of TNF-alpha, IL-6, and IL-8 by LPS-activated human monocytes with a differential potency. Adenosine 35-44 interleukin 6 Homo sapiens 83-87 7930619-8 1994 In contrast, adenosine enhanced production of IL-6 and IL-8 by monocytes stimulated with IL-1 beta. Adenosine 13-22 interleukin 6 Homo sapiens 46-50 7947352-5 1994 Specifically, RU486 (at concentrations of 1-100 nM) exerts pure antagonist actions by almost completely reversing the inhibitory effects of the glucocorticoid dexamethasone (Dex) on the release of monocyte/macrophages-derived lymphokines, such as IL-1, IL-6, IL-8 and tumor necrosis factor-alpha (TNF-alpha). Dexamethasone 159-172 interleukin 6 Homo sapiens 253-257 7523403-3 1994 In mammary cells or hybridoma B9 cells, four distinct tyrosine-phosphorylated transcription complexes activated by interleukin-6 (IL-6) and IFN-beta were observed: pIRFA and complexes I, II, and III (of increasing electrophoretic mobility). Tyrosine 54-62 interleukin 6 Homo sapiens 115-128 7523403-3 1994 In mammary cells or hybridoma B9 cells, four distinct tyrosine-phosphorylated transcription complexes activated by interleukin-6 (IL-6) and IFN-beta were observed: pIRFA and complexes I, II, and III (of increasing electrophoretic mobility). Tyrosine 54-62 interleukin 6 Homo sapiens 130-134 7847608-0 1994 Effect of acute and chronic alcohol administration to rats on the expression of interleukin-6 cell-surface receptors of hepatic parenchymal and nonparenchymal cells. Alcohols 28-35 interleukin 6 Homo sapiens 80-93 7988156-5 1994 Exogenous addition of prostaglandin E-2 to frozen PBMCs and monocytes inhibited LPS-induced IL-6 production. Dinoprostone 22-39 interleukin 6 Homo sapiens 92-96 7988156-6 1994 The results suggest that functional inactivation of a subset of cryosensitive, PGE-2-secreting monocytes is associated with an increase in IL-6 production by the other subset. Dinoprostone 79-84 interleukin 6 Homo sapiens 139-143 7926489-3 1994 Therefore, we investigated the effects of IL-6 alone and in combination with IL-1 beta on norepinephrine release. Norepinephrine 90-104 interleukin 6 Homo sapiens 42-46 7926489-5 1994 RESULTS: 1 ng/mL of IL-6 augmented 3H release, 100 ng/mL suppressed 3H release, whereas 10 ng/mL had no effect. Tritium 35-37 interleukin 6 Homo sapiens 20-24 7926489-6 1994 However, IL-6 (10 ng/mL) plus a subthreshold concentration of human recombinant IL-1 beta significantly suppressed 3H release, and this was abolished by adding anti-IL-6 antibody or an IL-1 receptor antagonist. Tritium 115-117 interleukin 6 Homo sapiens 9-13 7926489-6 1994 However, IL-6 (10 ng/mL) plus a subthreshold concentration of human recombinant IL-1 beta significantly suppressed 3H release, and this was abolished by adding anti-IL-6 antibody or an IL-1 receptor antagonist. Tritium 115-117 interleukin 6 Homo sapiens 165-169 7926489-7 1994 CONCLUSIONS: Because 3H release reflects [3H]norepinephrine release, our results show that IL-6 exerts a dual effect on norepinephrine release. Tritium 21-23 interleukin 6 Homo sapiens 91-95 7926489-7 1994 CONCLUSIONS: Because 3H release reflects [3H]norepinephrine release, our results show that IL-6 exerts a dual effect on norepinephrine release. Norepinephrine 45-59 interleukin 6 Homo sapiens 91-95 7926489-8 1994 Furthermore, there is synergism between IL-1 beta and IL-6 resulting in suppression of norepinephrine release. Norepinephrine 87-101 interleukin 6 Homo sapiens 54-58 7927706-0 1994 Anthrax edema toxin differentially regulates lipopolysaccharide-induced monocyte production of tumor necrosis factor alpha and interleukin-6 by increasing intracellular cyclic AMP. Cyclic AMP 169-179 interleukin 6 Homo sapiens 127-140 7930877-8 1994 Furthermore, when administered to 5-fluorouracil-treated mice, 5 micrograms/day of Peg-IL-6 diminished the platelet nadir and increased platelet counts on individual days during the recovery phase. Fluorouracil 34-48 interleukin 6 Homo sapiens 87-91 7947352-5 1994 Specifically, RU486 (at concentrations of 1-100 nM) exerts pure antagonist actions by almost completely reversing the inhibitory effects of the glucocorticoid dexamethasone (Dex) on the release of monocyte/macrophages-derived lymphokines, such as IL-1, IL-6, IL-8 and tumor necrosis factor-alpha (TNF-alpha). Dexamethasone 174-177 interleukin 6 Homo sapiens 253-257 7947352-6 1994 Dex decreased in a dose-dependent manner the release of the above four lymphokines, with an ID50 of 0.9 +/- 0.1, 4.76 +/- 0.4, 9.8 +/- 1.8, and 1.16 +/- 0.2 nM for IL-1, IL-6, IL-8 and TNF-alpha, respectively. Dexamethasone 0-3 interleukin 6 Homo sapiens 170-174 7800135-6 1994 An antisense phosphorothioate oligonucleotide against IL-6 messenger RNA inhibited both [3H]thymidine uptake and IL-6 secretion by acoustic neuroma cells in culture. Tritium 89-91 interleukin 6 Homo sapiens 54-58 7945501-2 1994 OBJECTIVE: To prevent the negative effects of interleukin-1 (IL-1) and IL-1-induced IL-6 on cartilage proteoglycan (PG) synthesis, we used an antisense oligonucleotide (ASO) specific for IL-6 messenger RNA (mRNA) to inhibit IL-6 production. Oligonucleotides 152-167 interleukin 6 Homo sapiens 84-88 7945501-2 1994 OBJECTIVE: To prevent the negative effects of interleukin-1 (IL-1) and IL-1-induced IL-6 on cartilage proteoglycan (PG) synthesis, we used an antisense oligonucleotide (ASO) specific for IL-6 messenger RNA (mRNA) to inhibit IL-6 production. Oligonucleotides 152-167 interleukin 6 Homo sapiens 187-191 7945501-2 1994 OBJECTIVE: To prevent the negative effects of interleukin-1 (IL-1) and IL-1-induced IL-6 on cartilage proteoglycan (PG) synthesis, we used an antisense oligonucleotide (ASO) specific for IL-6 messenger RNA (mRNA) to inhibit IL-6 production. Oligonucleotides 152-167 interleukin 6 Homo sapiens 187-191 8057147-3 1994 Constitutive IL-6 production was detected in all meningiomas studied, in the form of protein as well as IL-6-specific messenger ribonucleic acid. ribonucleic 128-139 interleukin 6 Homo sapiens 13-17 8057147-3 1994 Constitutive IL-6 production was detected in all meningiomas studied, in the form of protein as well as IL-6-specific messenger ribonucleic acid. ribonucleic 128-139 interleukin 6 Homo sapiens 104-108 8057147-5 1994 Interleukin-6 secretion was remarkably stimulated by tumor necrosis factor-alpha, IL-1 beta, and IL-4, and was also influenced by a combination of epidermal growth factor and bromocriptine. Bromocriptine 175-188 interleukin 6 Homo sapiens 0-13 7521688-4 1994 We also demonstrate that the DNA-binding protein STAT3 (also called the acute-phase response factor [APRF], activated by interleukin-6) is an early target of G-CSF-induced tyrosine phosphorylation. Tyrosine 172-180 interleukin 6 Homo sapiens 121-134 7529912-3 1994 In the present study, we examined the role of adenylate cyclase/cyclic 3",5"-adenosine monophosphate (cAMP) pathway in IL-6 release. Cyclic AMP 102-106 interleukin 6 Homo sapiens 119-123 7529912-4 1994 Agents which mimicked (dibutyryl cAMP) or stimulated (isoproterenol and forskolin) cAMP formation were found to induce IL-6 release and their effects could be potentiated by 3-isobutyl-1-methylxanthine (IBMX), a phosphodiesterase inhibitor. Cyclic AMP 33-37 interleukin 6 Homo sapiens 119-123 7529912-4 1994 Agents which mimicked (dibutyryl cAMP) or stimulated (isoproterenol and forskolin) cAMP formation were found to induce IL-6 release and their effects could be potentiated by 3-isobutyl-1-methylxanthine (IBMX), a phosphodiesterase inhibitor. Cyclic AMP 83-87 interleukin 6 Homo sapiens 119-123 8069925-7 1994 PGE1, a cAMP agonist, caused a 30-fold induction of IL-6 secretion. Cyclic AMP 8-12 interleukin 6 Homo sapiens 52-56 7519668-6 1994 Histamine (1-100 microM), substance P (SP; 1-100 nM), and human interleukin-1 beta (IL-1 beta; 1-30 pM) stimulated the release of IL-6 in a time- and concentration-dependent manner, with EC50 values of 4.5 microM, 8 nM, and 4.5 pM, respectively. Histamine 0-9 interleukin 6 Homo sapiens 130-134 7519668-8 1994 Both histamine and SP enhanced the formation of inositol phosphates and increase intracellular calcium levels, suggesting that the phosphatidylinositol bisphosphate/protein kinase C pathway may be involved in the IL-6 release process. Histamine 5-14 interleukin 6 Homo sapiens 213-217 7519668-8 1994 Both histamine and SP enhanced the formation of inositol phosphates and increase intracellular calcium levels, suggesting that the phosphatidylinositol bisphosphate/protein kinase C pathway may be involved in the IL-6 release process. Calcium 95-102 interleukin 6 Homo sapiens 213-217 7519668-9 1994 Indeed, phorbol 12-myristate 13-acetate, a protein kinase C activator, also evoked IL-6 release from the U373MG cells. Tetradecanoylphorbol Acetate 8-39 interleukin 6 Homo sapiens 83-87 7800135-7 1994 In addition, [3H]thymidine uptake was inhibited by a specific polyclonal antibody against IL-6. Tritium 14-16 interleukin 6 Homo sapiens 90-94 8045498-5 1994 Interleukin-1 beta and phorbol myristate acetate were also shown to induce in a dose-dependent fashion a threefold to fivefold increase of interleukin-6 production as measured by enzyme-linked immunosorbent assay in human primary biliary duct epithelium cultures, when compared with hepatocyte growth factor, epidermal growth factor, insulin-like growth factor, phytohemagglutinin, tumor necrosis factor-alpha or platelet-derived growth factor. Tetradecanoylphorbol Acetate 23-48 interleukin 6 Homo sapiens 139-152 7914891-7 1994 Differentiation of U937 cells by exposure to 12-O-tetradecanoyl phorbol-13-acetate abolishes response to IL-6 but not IFN-gamma. Tetradecanoylphorbol Acetate 45-82 interleukin 6 Homo sapiens 105-109 8050200-1 1994 The effect of hydrocortisone (HC) on IL-6 production by monocytes (Mo) that were cultured under either adherent or limited-adherent culture conditions was determined. Hydrocortisone 14-28 interleukin 6 Homo sapiens 37-41 8050200-1 1994 The effect of hydrocortisone (HC) on IL-6 production by monocytes (Mo) that were cultured under either adherent or limited-adherent culture conditions was determined. Hydrocortisone 30-32 interleukin 6 Homo sapiens 37-41 7999921-9 1994 The reductions in urinary calcium excretion, serum osteocalcin, and the static bone parameters are consistent with an IL-6 induced reduction in bone formation or turnover. Calcium 26-33 interleukin 6 Homo sapiens 118-122 7914487-4 1994 Subsequent dimerisation of these intermediate forms into 16-kDa IL-6- and 14-kDa IGF-1-derived peptides was inhibited by acivicin and glutathione which are specific inhibitors of the standard cell-surface gamma-glutamyl transpeptidase (gamma-GT). Glutathione 134-145 interleukin 6 Homo sapiens 64-68 7831669-0 1994 Platelet activation induced by interleukin-6: evidence for a mechanism involving arachidonic acid metabolism. Arachidonic Acid 81-97 interleukin 6 Homo sapiens 31-44 7831669-5 1994 Further, PRP incubated with IL-6 showed a dose dependent increase in TXB2 and BTG secretion as measured by RIA and an increased incorporation of actin binding protein, talin, and myosin into the cytoskeletal core (triton insoluble residue) as shown by SDS-PAGE. Sodium Dodecyl Sulfate 252-255 interleukin 6 Homo sapiens 28-32 7831669-7 1994 These results suggest that IL-6 activates platelets in vitro and enhances AIMA via a mechanism involving arachidonic acid metabolism. Arachidonic Acid 105-121 interleukin 6 Homo sapiens 27-31 8034686-2 1994 IL-6 expression is induced in young human diploid fibroblasts (HDF) in response to a number of agents including fetal bovine serum, 12-O-tetradecanoylphorbol-13-acetate, double-stranded RNA, and forskolin. Tetradecanoylphorbol Acetate 132-168 interleukin 6 Homo sapiens 0-4 8034686-3 1994 In contrast, we find that senescent HDF are markedly deficient in their ability to express IL-6 in response to serum, double-stranded RNA, and 12-O-tetradecanoyl-phorbol-13-acetate, whereas forskolin is still an effective inducer for senescent cells. Tetradecanoylphorbol Acetate 143-180 interleukin 6 Homo sapiens 91-95 7518681-3 1994 Interestingly, the Stat91 transcription factor essential for interferon signaling mediated by JAK-TYK kinases was significantly tyrosine phosphorylated in response to IL-6 in ANBL-6 cells but not in the other cell lines. Tyrosine 128-136 interleukin 6 Homo sapiens 167-171 7518681-4 1994 We further show that IL-11, a cytokine that signals via the gp130 subunit of the IL-6 receptor, induced similar profiles of JAK-TYK tyrosine phosphorylation as IL-6 in B9E and T10D cells. Tyrosine 132-140 interleukin 6 Homo sapiens 81-85 7973432-3 1994 METHODS: In vitro secretion of IL-6 by biopsy specimens from patients with active ulcerative colitis was investigated in the presence of cyclosporin-A (CsA) and drugs that have other anti-inflammatory actions. Cyclosporine 152-155 interleukin 6 Homo sapiens 31-35 7973432-5 1994 RESULTS: Stimulation of control specimens increased IL-6 secretion (median increase, 147%; p < 0.003), which was prevented by CsA. Cyclosporine 129-132 interleukin 6 Homo sapiens 52-56 7914487-9 1994 The N/O-glycosylated IL-6 was clearly as sensitive to cathepsin-G- and gamma-GT-related activities as the unglycosylated IL-6 from Escherichia coli, thus indicating that the sugar chains did not protect the cleavage sites of the two proteases on the IL-6 molecule. Nitrogen 4-5 interleukin 6 Homo sapiens 21-25 8055910-3 1994 To find a possible activity of IL-6 on these cells, a cDNA library of IL-6- and dexamethasone-treated cells was screened with cDNA probes from both induced and non-induced cells. Dexamethasone 80-93 interleukin 6 Homo sapiens 31-35 8055910-10 1994 IL-6 and dexamethasone induce a state of resistance against hydrogen peroxide toxicity in UAC cells. Hydrogen Peroxide 60-77 interleukin 6 Homo sapiens 0-4 7519403-7 1994 Both IL-1 and TNF increased release of IL-6 and IL-8 from the cells in a dose-dependent manner and dexamethasone inhibited this effect. Dexamethasone 99-112 interleukin 6 Homo sapiens 39-43 7986583-6 1994 Both anti-IL-6 antibodies and IL-6 antisense oligonucleotides inhibited Tat-induced IgG and IgA synthesis to some degree, whereas induction of IgM appeared to be independent of IL-6. Oligonucleotides 45-61 interleukin 6 Homo sapiens 30-34 7986583-6 1994 Both anti-IL-6 antibodies and IL-6 antisense oligonucleotides inhibited Tat-induced IgG and IgA synthesis to some degree, whereas induction of IgM appeared to be independent of IL-6. Oligonucleotides 45-61 interleukin 6 Homo sapiens 30-34 7519403-3 1994 Dexamethasone blocks the induction of IL-6 and IL-8 by IL-1 or TNF. Dexamethasone 0-13 interleukin 6 Homo sapiens 38-42 7519403-8 1994 Dexamethasone also inhibited the induction of IL-6 and IL-8 RNA by IL-1 and TNF. Dexamethasone 0-13 interleukin 6 Homo sapiens 46-50 7519403-4 1994 In these studies, we determined whether dexamethasone interferes with the upregulation of IL-6 and IL-8 by downregulating expression of the IL-1 or TNF receptor genes. Dexamethasone 40-53 interleukin 6 Homo sapiens 90-94 7912755-10 1994 Culture supernatants from blasts cultured with or without TPA showed the production of large amounts of IL-8, IL-6, TNF-alpha, MIP-1 alpha, IL-10 and interferon gamma and modest amounts of IL-1 alpha, GM-CSF and stem cell factor. Tetradecanoylphorbol Acetate 58-61 interleukin 6 Homo sapiens 110-114 8013439-0 1994 Cadmium inhibits IL-6 production and IL-6 mRNA expression in a human monocytic cell line, THP-1. Cadmium 0-7 interleukin 6 Homo sapiens 17-21 8013439-0 1994 Cadmium inhibits IL-6 production and IL-6 mRNA expression in a human monocytic cell line, THP-1. Cadmium 0-7 interleukin 6 Homo sapiens 37-41 8013439-3 1994 The purpose of this study was to determine whether there were changes in interleukin-6 (IL-6) production, a pleiotropic cytokine, when an activated human monocytic cell line was exposed to cadmium. Cadmium 189-196 interleukin 6 Homo sapiens 73-86 8013439-3 1994 The purpose of this study was to determine whether there were changes in interleukin-6 (IL-6) production, a pleiotropic cytokine, when an activated human monocytic cell line was exposed to cadmium. Cadmium 189-196 interleukin 6 Homo sapiens 88-92 8013439-4 1994 Results suggest that there were statistically significant lower levels of IL-6 at 0.06 mM cadmium (P < 0.05), and 0.8 and 0.1 mM cadmium (P < 0.01), determined via the ELISA method. Cadmium 90-97 interleukin 6 Homo sapiens 74-78 8013439-4 1994 Results suggest that there were statistically significant lower levels of IL-6 at 0.06 mM cadmium (P < 0.05), and 0.8 and 0.1 mM cadmium (P < 0.01), determined via the ELISA method. Cadmium 132-139 interleukin 6 Homo sapiens 74-78 8013439-5 1994 IL-6 messenger RNA (mRNA) levels were also decreased at these cadmium concentrations. Cadmium 62-69 interleukin 6 Homo sapiens 0-4 7928300-2 1994 Both MDP and romurtide stimulated the production of interleukin-1 (IL-1), IL-6, tumor necrosis factor (TNF) and IL-1 receptor antagonist (IL-1Ra). romurtide 13-22 interleukin 6 Homo sapiens 74-78 7928300-5 1994 Dose-response study indicated that romurtide was far more potent than MDP in induction of IL-1, IL-6 and TNF. romurtide 35-44 interleukin 6 Homo sapiens 96-100 7812050-1 1994 Recent evidence has shown that members of the Jak kinase family are activated after IL-6 binds to its receptor complex, leading to a tyrosine phosphorylation of gp130, the IL-6 signal-transducing subunit. Tyrosine 133-141 interleukin 6 Homo sapiens 84-88 7812050-1 1994 Recent evidence has shown that members of the Jak kinase family are activated after IL-6 binds to its receptor complex, leading to a tyrosine phosphorylation of gp130, the IL-6 signal-transducing subunit. Tyrosine 133-141 interleukin 6 Homo sapiens 172-176 7515712-3 1994 In this study, we showed that hematopoietic cytokines, such as IL-3, IL-6, and G-CSF, all induced tyrosine-phosphorylation of Stat family proteins and Stat-associated 150-kD and 72-kD molecules in hematopoietic lineage cell lines. Tyrosine 98-106 interleukin 6 Homo sapiens 69-73 7716932-3 1994 The correlations calculated between TNF-alpha and Il-6 concentrations calculated between TNF-alpha and Il-6 concentrations and laboratory parameters (laboratory indicators of hepatitis activity--AlAT; liver function indicators--prothrombin index, bilirubin concentration, bile acid concentration, alkaline phosphatase activity, anti-pyrin half-life) were non-significant in Spearman non-parametric test (p > 0.005) except for the correlation between albumin and TNF-alpha concentrations. Bile Acids and Salts 272-281 interleukin 6 Homo sapiens 50-54 8004813-6 1994 Dexamethasone suppressed both gene expression and protein production of GM-CSF, IL-6 and IL-8 when fibroblasts were exposed to IL-1 alpha. Dexamethasone 0-13 interleukin 6 Homo sapiens 80-84 7516173-6 1994 A greater than 95% decrease in IL-6 production was seen with 10(-6) and 10(-7) M dexamethasone, prednisolone, and hydrocortisone, and IC50 values for these agents were approximately 5 x 10(-10), 5 x 10(-9), and 10(-8) M, respectively. Dexamethasone 81-94 interleukin 6 Homo sapiens 31-35 7516173-6 1994 A greater than 95% decrease in IL-6 production was seen with 10(-6) and 10(-7) M dexamethasone, prednisolone, and hydrocortisone, and IC50 values for these agents were approximately 5 x 10(-10), 5 x 10(-9), and 10(-8) M, respectively. Hydrocortisone 114-128 interleukin 6 Homo sapiens 31-35 7516173-9 1994 However, the magnitude of this effect could not fully account for the potency of the glucocorticoid-induced alterations in IL-6 mRNA accumulation and protein production since 10(-6) M dexamethasone caused only a 50% decrease in IL-1-induced IL-6 gene transcription. Dexamethasone 184-197 interleukin 6 Homo sapiens 241-245 8004821-2 1994 Results show that rapamycin strongly inhibited production of both IgM and IgG measured at the end of the secondary culture supported by IL-2/IL-6, whereas CsA up-regulated the immunoglobulin production. Sirolimus 18-27 interleukin 6 Homo sapiens 141-145 7949016-1 1994 To investigate the role of interleukins on the growth of human thyroid cells, the effect of IL-2, IL-4 and IL-6 was studied on EGF-induced [3H]-thymidine uptake, cell cycle by flow cytometry, and mRNA levels of cellular proto-oncogene c-fos in thyroid monolayer cells from eighteen patients with Graves" disease and sixteen with non-thyroidal disease. Tritium 140-142 interleukin 6 Homo sapiens 107-111 7949016-7 1994 IL-6 (10(-2)-10 ng/ml) stimulated the [3H]-thymidine uptake up to 218-303 % of control level, and the percentage of cells in S+G2/M phase was increased in IL-6-treated normal thyroid cells as compared to EGF-treated cells. Tritium 39-41 interleukin 6 Homo sapiens 0-4 8004881-7 1994 A parallel twofold increase in AM1 concentrations was observed, followed by a three-fold increase in cyclosporine levels, which peaked 4.8 days after interleukin-6. Cyclosporine 101-113 interleukin 6 Homo sapiens 150-163 8004881-8 1994 The times of peak cyclosporine and AM1 levels correlated with the time of peak interleukin-6 levels. Cyclosporine 18-30 interleukin 6 Homo sapiens 79-92 8004881-10 1994 CONCLUSIONS: An inflammatory reaction could be an important source of intraindividual variability in cyclosporine pharmacokinetics, possibly through an inhibition of cytochrome P4503A-dependent enzyme activities by endogenous interleukin-6. Cyclosporine 101-113 interleukin 6 Homo sapiens 226-239 8079262-4 1994 Before treatment the patient with Sweet"s syndrome had high serum levels of interleukin 6 (IL-6), which were reduced to zero after treatment with steroids. Steroids 146-154 interleukin 6 Homo sapiens 76-89 8188340-5 1994 TNF, GM-CSF, and IL-8 strongly primed a subpopulation of PMN to produce H2O2 in response to N-formyl-methionyl-leucyl-phenylalanine (FMLP), while IL-1 alpha, IL-1 beta, and IL-6 failed to do so. Hydrogen Peroxide 72-76 interleukin 6 Homo sapiens 173-177 8079262-4 1994 Before treatment the patient with Sweet"s syndrome had high serum levels of interleukin 6 (IL-6), which were reduced to zero after treatment with steroids. Steroids 146-154 interleukin 6 Homo sapiens 91-95 8179912-0 1994 Alveolar macrophages from patients with beryllium disease and sarcoidosis express increased levels of mRNA for tumor necrosis factor-alpha and interleukin-6 but not interleukin-1 beta. Beryllium 40-49 interleukin 6 Homo sapiens 143-156 8195587-7 1994 The effect of IL-6 was potentiated by dexamethasone, while an inhibition on HP mRNA inducibility could be prevented by lowering the foetal calf serum (FCS) concentration to 1%. Dexamethasone 38-51 interleukin 6 Homo sapiens 14-18 8172889-0 1994 Roles of disulfide bonds in recombinant human interleukin 6 conformation. Disulfides 9-18 interleukin 6 Homo sapiens 46-59 8172889-1 1994 Human IL-6 has two disulfide bonds linking Cys45 to Cys51 and Cys74 to Cys84, respectively. Disulfides 19-28 interleukin 6 Homo sapiens 6-10 8172889-3 1994 To address the structural importance of these disulfide bonds in the formation and stabilization of IL-6 secondary and tertiary structures, we have generated a panel of disulfide bond-deficient rIL-6 analogs both by chemical reduction and alkylation as well as by site-directed mutagenesis. Disulfides 46-55 interleukin 6 Homo sapiens 100-104 8172889-10 1994 Our results suggest that the second disulfide bridge plays a critical role in maintaining the spatial relationship between the putative IL-6 A and D helices. Disulfides 36-45 interleukin 6 Homo sapiens 136-140 8179912-3 1994 We hypothesized that alveolar macrophages and bronchoalveolar lavage fluid from patients with beryllium disease and sarcoidosis would express increased levels of mRNA and proteins, respectively, for TNF-alpha, IL-1 beta, and IL-6 compared with those of normal individuals. Beryllium 94-103 interleukin 6 Homo sapiens 225-229 8179912-6 1994 In patients with beryllium disease (n = 23), we observed elevated macrophage mRNA expression for TNF-alpha and IL-6 when compared with that of normal subjects (n = 7). Beryllium 17-26 interleukin 6 Homo sapiens 111-115 7920181-6 1994 Here, adding recombinant human (rh)IL-6 to GC cultures inhibited differentiated functions induced by FSH such as aromatase activity, LH receptor (LHr) expression measured by specific 125I-hCG binding and progesterone (P) production. Progesterone 204-216 interleukin 6 Homo sapiens 35-39 7920181-8 1994 These preliminary results clearly showed that IL-6 acted differently on FSH and hCG induced functions although these gonadotropins act primarily through the same transduction pathway involving generation of cyclic AMP. Cyclic AMP 207-217 interleukin 6 Homo sapiens 46-50 8189461-7 1994 Interleukin 6 levels correlated positively with protein turnover (phenylalaninemia) and catabolism (3-methylhistidine/creatinine ratio) and negatively with levels of fibronectin and transthyretin. Creatinine 118-128 interleukin 6 Homo sapiens 0-13 8168970-0 1994 Noradrenaline inhibits lipopolysaccharide-induced tumor necrosis factor and interleukin 6 production in human whole blood. Norepinephrine 0-13 interleukin 6 Homo sapiens 76-89 8168970-3 1994 The present study sought insight into the effect of noradrenaline on LPS-induced release of tumor necrosis factor alpha (TNF) and interleukin 6 (IL-6) in human whole blood. Norepinephrine 52-65 interleukin 6 Homo sapiens 130-143 8168970-3 1994 The present study sought insight into the effect of noradrenaline on LPS-induced release of tumor necrosis factor alpha (TNF) and interleukin 6 (IL-6) in human whole blood. Norepinephrine 52-65 interleukin 6 Homo sapiens 145-149 8168970-5 1994 Noradrenaline caused a dose-dependent inhibition of LPS-induced TNF and IL-6 production. Norepinephrine 0-13 interleukin 6 Homo sapiens 72-76 8168970-9 1994 In acute sepsis, enhanced release of noradrenaline may be part of a negative feedback mechanism meant to inhibit ongoing TNF and IL-6 production. Norepinephrine 37-50 interleukin 6 Homo sapiens 129-133 8181515-1 1994 Random substitutions of amino acid 161-184 of human interleukin-6 (hIL-6) have been generated at the cDNA level using oligonucleotide-directed mutagenesis. Oligonucleotides 118-133 interleukin 6 Homo sapiens 52-65 8181515-1 1994 Random substitutions of amino acid 161-184 of human interleukin-6 (hIL-6) have been generated at the cDNA level using oligonucleotide-directed mutagenesis. Oligonucleotides 118-133 interleukin 6 Homo sapiens 67-72 7928664-4 1994 At the same concentrations, IL-6 also significantly enhanced spontaneous as well as calcium ionophore-induced acrosome reaction and release of acrosin from the human sperm cells. Calcium 84-91 interleukin 6 Homo sapiens 28-32 8041811-4 1994 This early peak of IL-1 bioactivity appears to be responsible for the induction of IL-6 synthesis and together with IL-6 lead to an increase of the steady-state mRNA level of collagenase/MMP-1 as deduced from studies using IL-1 alpha and IL-1 beta antisense oligonucleotides or neutralizing antibodies against IL-1 alpha and IL-1 beta. Oligonucleotides 258-274 interleukin 6 Homo sapiens 83-87 8041811-4 1994 This early peak of IL-1 bioactivity appears to be responsible for the induction of IL-6 synthesis and together with IL-6 lead to an increase of the steady-state mRNA level of collagenase/MMP-1 as deduced from studies using IL-1 alpha and IL-1 beta antisense oligonucleotides or neutralizing antibodies against IL-1 alpha and IL-1 beta. Oligonucleotides 258-274 interleukin 6 Homo sapiens 116-120 7512571-0 1994 Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors. Tyrosine 110-118 interleukin 6 Homo sapiens 55-68 7913397-1 1994 We examined the effect of interleukin-6 (human recombinant) on glutamate-induced neuronal death of cultured 20-day fetal rat hippocampal neurons. Glutamic Acid 63-72 interleukin 6 Homo sapiens 26-39 7764745-4 1994 We also observed that the yield of soluble and properly refolded mutein IL-6 was highest when the cysteines at position 74 and 84 were left intact. Cysteine 98-107 interleukin 6 Homo sapiens 72-76 7764745-5 1994 The mutein IL-6 with cysteines at position 74 and 84 was as active as wild-type IL-6 and a lower concentration of the mutein IL-6 was required to reach maximal activity, compared to wild-type IL-6. Cysteine 21-30 interleukin 6 Homo sapiens 11-15 7764745-6 1994 The mutein IL-6 with cysteines at position 45 and 51 had a much reduced biological activity. Cysteine 21-30 interleukin 6 Homo sapiens 11-15 7512571-2 1994 Here we report that CNTF, LIF, OSM, and IL6 induce most of the same protein tyrosine phosphorylations, regardless of the cell type assayed or whether they initiate signaling by inducing homo- or heterodimerization of beta components. Tyrosine 76-84 interleukin 6 Homo sapiens 40-43 7512730-6 1994 Either acidic fibroblast growth factor or phorbol 12-myristate 13-acetate can replace serum as a cofactor in IL-6-induced ZR-75-1-Tx cell detachment. Tetradecanoylphorbol Acetate 42-73 interleukin 6 Homo sapiens 109-113 7511596-0 1994 Histamine enhances interleukin (IL)-1-induced IL-6 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells. Histamine 0-9 interleukin 6 Homo sapiens 46-50 8159722-10 1994 In addition, cultured smooth muscle cells expressed SAA1, SAA2, and SAA4 mRNAs when treated with interleukin 1 or 6 (IL-1 or IL-6) in the presence of dexamethasone. Dexamethasone 150-163 interleukin 6 Homo sapiens 125-129 8168335-9 1994 Both phorbol myristate acetate and N-formyl-methionyl-leucylphenylalanine induced further release of nitric oxide, which was increased by preincubation with lipopolysaccharide, interleukin-6 and interferon-gamma. Nitric Oxide 101-113 interleukin 6 Homo sapiens 177-190 7512451-4 1994 The cloned APRF protein is tyrosine phosphorylated and translocated into the nucleus in response to IL-6, but not in response to IFN-gamma. Tyrosine 27-35 interleukin 6 Homo sapiens 100-104 7512451-5 1994 Tyrosine phosphorylation was also observed in response to other cytokines, such as leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor, whose receptors share the IL-6 receptor signal transducer gp130. Tyrosine 0-8 interleukin 6 Homo sapiens 184-188 8168335-9 1994 Both phorbol myristate acetate and N-formyl-methionyl-leucylphenylalanine induced further release of nitric oxide, which was increased by preincubation with lipopolysaccharide, interleukin-6 and interferon-gamma. Tetradecanoylphorbol Acetate 5-30 interleukin 6 Homo sapiens 177-190 7511596-1 1994 The regulation of interleukin (IL)-6 synthesis by cAMP-increasing agents remains an unresolved issue. Cyclic AMP 50-54 interleukin 6 Homo sapiens 18-36 7511596-5 1994 92, 281-287), we investigated whether histamine regulates IL-6 synthesis. Histamine 38-47 interleukin 6 Homo sapiens 58-62 7511596-9 1994 Histamine (1-100 microM) enhanced IL-1 alpha-induced synthesis of IL-6 (p < 0.001). Histamine 0-9 interleukin 6 Homo sapiens 66-70 7511596-10 1994 Cimetidine and ranitidine, H2 receptor antagonists structurally unrelated to each other, completely reversed the histamine-mediated increase in IL-1 alpha-induced IL-6 synthesis. Histamine 113-122 interleukin 6 Homo sapiens 163-167 7511596-12 1994 Prostaglandin E2, an activator of adenylate cyclase, also enhanced IL-1 alpha-induced synthesis of IL-6. Dinoprostone 0-16 interleukin 6 Homo sapiens 99-103 7511596-13 1994 Histamine increased and sustained steady-state levels of IL-6 mRNA in IL-1 alpha-stimulated cells, but reduced IL-6 mRNA half-life (3.5 h versus 1.8 h). Histamine 0-9 interleukin 6 Homo sapiens 57-61 7511596-13 1994 Histamine increased and sustained steady-state levels of IL-6 mRNA in IL-1 alpha-stimulated cells, but reduced IL-6 mRNA half-life (3.5 h versus 1.8 h). Histamine 0-9 interleukin 6 Homo sapiens 111-115 7511596-14 1994 Our results indicate that cAMP-increasing agents, such as histamine or prostaglandin E2, fail to induce IL-6 synthesis but rather enhance IL-1-induced IL-6 synthesis. Cyclic AMP 26-30 interleukin 6 Homo sapiens 151-155 7511596-14 1994 Our results indicate that cAMP-increasing agents, such as histamine or prostaglandin E2, fail to induce IL-6 synthesis but rather enhance IL-1-induced IL-6 synthesis. Histamine 58-67 interleukin 6 Homo sapiens 151-155 7511596-14 1994 Our results indicate that cAMP-increasing agents, such as histamine or prostaglandin E2, fail to induce IL-6 synthesis but rather enhance IL-1-induced IL-6 synthesis. Dinoprostone 71-87 interleukin 6 Homo sapiens 151-155 7930379-1 1994 Variations in the serum concentration of interleukin-6 (IL-6) have been reported concomitantly with thyroid dysfunction: increased serum IL-6 levels have been found in patients with thyroidal destructive processes, such as subacute thyroiditis, some forms of amiodarone-induced thyrotoxicosis, or after percutaneous ethanol injection into "hot" thyroid nodules, as a result of the cytokine release from the damaged thyrocyte. Amiodarone 259-269 interleukin 6 Homo sapiens 41-54 7930379-1 1994 Variations in the serum concentration of interleukin-6 (IL-6) have been reported concomitantly with thyroid dysfunction: increased serum IL-6 levels have been found in patients with thyroidal destructive processes, such as subacute thyroiditis, some forms of amiodarone-induced thyrotoxicosis, or after percutaneous ethanol injection into "hot" thyroid nodules, as a result of the cytokine release from the damaged thyrocyte. Amiodarone 259-269 interleukin 6 Homo sapiens 56-60 7930379-1 1994 Variations in the serum concentration of interleukin-6 (IL-6) have been reported concomitantly with thyroid dysfunction: increased serum IL-6 levels have been found in patients with thyroidal destructive processes, such as subacute thyroiditis, some forms of amiodarone-induced thyrotoxicosis, or after percutaneous ethanol injection into "hot" thyroid nodules, as a result of the cytokine release from the damaged thyrocyte. Amiodarone 259-269 interleukin 6 Homo sapiens 137-141 7930379-1 1994 Variations in the serum concentration of interleukin-6 (IL-6) have been reported concomitantly with thyroid dysfunction: increased serum IL-6 levels have been found in patients with thyroidal destructive processes, such as subacute thyroiditis, some forms of amiodarone-induced thyrotoxicosis, or after percutaneous ethanol injection into "hot" thyroid nodules, as a result of the cytokine release from the damaged thyrocyte. Ethanol 316-323 interleukin 6 Homo sapiens 41-54 7930379-1 1994 Variations in the serum concentration of interleukin-6 (IL-6) have been reported concomitantly with thyroid dysfunction: increased serum IL-6 levels have been found in patients with thyroidal destructive processes, such as subacute thyroiditis, some forms of amiodarone-induced thyrotoxicosis, or after percutaneous ethanol injection into "hot" thyroid nodules, as a result of the cytokine release from the damaged thyrocyte. Ethanol 316-323 interleukin 6 Homo sapiens 56-60 7930379-1 1994 Variations in the serum concentration of interleukin-6 (IL-6) have been reported concomitantly with thyroid dysfunction: increased serum IL-6 levels have been found in patients with thyroidal destructive processes, such as subacute thyroiditis, some forms of amiodarone-induced thyrotoxicosis, or after percutaneous ethanol injection into "hot" thyroid nodules, as a result of the cytokine release from the damaged thyrocyte. Ethanol 316-323 interleukin 6 Homo sapiens 137-141 8140422-0 1994 Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Tyrosine 41-49 interleukin 6 Homo sapiens 109-122 7510778-0 1994 Tumor necrosis factor-alpha (TNF-alpha), interferon-gamma, and interleukin-6 but not TNF-beta induce differentiation of neuroblastoma cells: the role of nitric oxide. Nitric Oxide 153-165 interleukin 6 Homo sapiens 63-76 8145046-4 1994 Dose-dependent proliferation of the cells in response to OSM, LIF, and IL-6, but not to IL-11, was observed using [3H]TdR incorporation in vitro. Tritium 115-117 interleukin 6 Homo sapiens 71-75 8140422-2 1994 A new family member, Stat3, becomes activated through phosphorylation on tyrosine as a DNA binding protein in response to epidermal growth factor (EGF) and interleukin-6 (IL-6) but not interferon gamma (IFN-gamma). Tyrosine 73-81 interleukin 6 Homo sapiens 156-169 8140422-2 1994 A new family member, Stat3, becomes activated through phosphorylation on tyrosine as a DNA binding protein in response to epidermal growth factor (EGF) and interleukin-6 (IL-6) but not interferon gamma (IFN-gamma). Tyrosine 73-81 interleukin 6 Homo sapiens 171-175 8019842-4 1994 In the present paper we show that human IL-1 and IL-6 are able to induce changes on protein phosphorylation in the leech central nervous system and that these changes are similar to those ones induced by the neurotransmitter serotonin. Serotonin 225-234 interleukin 6 Homo sapiens 49-53 8050053-2 1994 To examine this further, the effect of interleukin-1 beta (IL-1 beta), interleukin-1 alpha (IL-1 alpha), and interleukin-6 (IL-6) on prostaglandin output by dispersed cells from human amnion, chorion laeve, and decidua obtained at term (38-40 weeks gestation) was examined. Prostaglandins 133-146 interleukin 6 Homo sapiens 124-128 8118041-10 1994 Anti-interleukin-6 reduced the increase in intracellular H2O2 production in group III patients and significantly altered the exaggerated oxidative response to NaF. Hydrogen Peroxide 57-61 interleukin 6 Homo sapiens 5-18 8132780-0 1994 17 beta-Estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism. Estradiol 3-17 interleukin 6 Homo sapiens 47-60 8132780-1 1994 We previously reported that 17 beta-estradiol inhibits cytokine-stimulated bioassayable IL-6 and the steady-state level of IL-6 mRNA. Estradiol 28-45 interleukin 6 Homo sapiens 88-92 8132780-1 1994 We previously reported that 17 beta-estradiol inhibits cytokine-stimulated bioassayable IL-6 and the steady-state level of IL-6 mRNA. Estradiol 28-45 interleukin 6 Homo sapiens 123-127 8132780-3 1994 17 beta-estradiol (10(-8) M) completely suppressed stimulated CAT expression in HeLa cells cotransfected with IL-6/CAT constructs and a human estrogen receptor (hER) expression plasmid; but had no effect on reporter expression in HeLa cells not transfected with hER. Estradiol 3-17 interleukin 6 Homo sapiens 110-114 8132780-7 1994 These data suggest that 17 beta-estradiol inhibits the stimulated expression of the human IL-6 gene through an estrogen receptor mediated indirect effect on the transcriptional activity of the proximal 225-bp sequence of the promoter. Estradiol 27-41 interleukin 6 Homo sapiens 90-94 8159270-8 1994 IL-6, like IL-1 beta, also potentiated acetylcholine-induced AVP release, but to a lesser extent. Acetylcholine 39-52 interleukin 6 Homo sapiens 0-4 8159270-11 1994 Our results suggest a hypothalamic site of action of IL-1 beta and IL-6 on the acetylcholine-induced AVP release. Acetylcholine 79-92 interleukin 6 Homo sapiens 67-71 8306027-6 1994 In contrast, GM-CSF and IL-6 showed a delayed rise (peak, 26.4 +/- 1.3 pg/ml and 33.8 +/- 10.0 pg/ml, respectively) at hour 4 in the antigen-challenge period (p < 0.01 versus saline). Sodium Chloride 178-184 interleukin 6 Homo sapiens 24-28 8161348-5 1994 Consistent with this hypothesis, simultaneous treatment of cells with Sn-mesoporphyrin, an inhibitor of heme oxygenase, prevented the IL-6-mediated suppression of CYPIA1. tin mesoporphyrin 70-86 interleukin 6 Homo sapiens 134-138 7510687-8 1994 An 35S-labeled, 60-kDa protein was immunoprecipitated with anti-LBP antibody from IL-6-stimulated HepG2 cell supernatants. Sulfur-35 3-6 interleukin 6 Homo sapiens 82-86 8122626-0 1994 Dexamethasone inhibits production of interleukin-6 by cultured cardiac myxoma cells. Dexamethasone 0-13 interleukin 6 Homo sapiens 37-50 8199014-2 1994 The results demonstrate that on activation with the calcium ionophore A23187 both M-CSF and IL-6 mRNA are induced after 3 and 6 h respectively. Calcium 52-59 interleukin 6 Homo sapiens 92-96 8199014-3 1994 Co-stimulation with A23187 plus PMA resulted in an up-regulation of M-CSF mRNA and a down-regulation of IL-6 mRNA. Tetradecanoylphorbol Acetate 32-35 interleukin 6 Homo sapiens 104-108 7719378-5 1994 Prior rIL-2 immunotherapy had no measurable effect on rIL-2 induced IL-6 release, while steroids resulted in a significant suppression of secondary IL-6 did not correlate with response to rIL-2 therapy or survival of rIL-2 treated renal cell carcinoma patients. Steroids 88-96 interleukin 6 Homo sapiens 148-152 8181907-2 1994 Administration of recombinant human IL-6 or TNF to rats caused the acute phase responses including rapid decreases in plasma zinc (Zn), and increases in plasma copper (Cu) and ceruloplasmin. Zinc 131-133 interleukin 6 Homo sapiens 36-40 8181907-2 1994 Administration of recombinant human IL-6 or TNF to rats caused the acute phase responses including rapid decreases in plasma zinc (Zn), and increases in plasma copper (Cu) and ceruloplasmin. Copper 160-166 interleukin 6 Homo sapiens 36-40 8181907-2 1994 Administration of recombinant human IL-6 or TNF to rats caused the acute phase responses including rapid decreases in plasma zinc (Zn), and increases in plasma copper (Cu) and ceruloplasmin. Copper 168-170 interleukin 6 Homo sapiens 36-40 8301142-0 1994 Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts. Tretinoin 0-13 interleukin 6 Homo sapiens 41-45 8301142-9 1994 13-cis-retinoic acid, retinol, retinaldehyde, all-trans etretin, Ro 13-6298, and 9-cis retinoic acid also inhibited IL-1-induced IL-6 production. Acitretin 56-63 interleukin 6 Homo sapiens 129-133 8186320-3 1994 In our experiments Zn2+ ions, added as ZnSO4, stimulated PBMC to produce IFN-gamma, IL-1 beta, IL-6, TNF-alpha, and sIL-2R in a concentration-dependent manner. Zinc 19-23 interleukin 6 Homo sapiens 95-99 8186320-3 1994 In our experiments Zn2+ ions, added as ZnSO4, stimulated PBMC to produce IFN-gamma, IL-1 beta, IL-6, TNF-alpha, and sIL-2R in a concentration-dependent manner. Zinc Sulfate 39-44 interleukin 6 Homo sapiens 95-99 8146727-16 1994 In case 1, symptoms improved and the IL-6 level normalized after steroid treatment. Steroids 65-72 interleukin 6 Homo sapiens 37-41 7985490-7 1994 The HCL-O cells spontaneously produced a large quantity of interleukin-6 (IL-6) in the conditioned medium, whereas IL-6 serum level was not so high. hcl-o 4-9 interleukin 6 Homo sapiens 59-72 7985490-7 1994 The HCL-O cells spontaneously produced a large quantity of interleukin-6 (IL-6) in the conditioned medium, whereas IL-6 serum level was not so high. hcl-o 4-9 interleukin 6 Homo sapiens 74-78 7865847-5 1994 Heat induction of HSF is inhibited in cells overexpressing hsp27, although metal ions and amino acid analogs are still capable of activating HSF. Metals 75-80 interleukin 6 Homo sapiens 141-144 8275438-4 1994 RESULTS: In the patients not given the drug, circulating interleukin-6 (IL-6) markedly increased 1 day after TAE, reached a peak (approximately 8 times the pretreatment value) after 4 days, and remained elevated 7 days after TAE. tae 109-112 interleukin 6 Homo sapiens 57-70 8275438-4 1994 RESULTS: In the patients not given the drug, circulating interleukin-6 (IL-6) markedly increased 1 day after TAE, reached a peak (approximately 8 times the pretreatment value) after 4 days, and remained elevated 7 days after TAE. tae 109-112 interleukin 6 Homo sapiens 72-76 8275438-4 1994 RESULTS: In the patients not given the drug, circulating interleukin-6 (IL-6) markedly increased 1 day after TAE, reached a peak (approximately 8 times the pretreatment value) after 4 days, and remained elevated 7 days after TAE. tae 225-228 interleukin 6 Homo sapiens 57-70 8275438-4 1994 RESULTS: In the patients not given the drug, circulating interleukin-6 (IL-6) markedly increased 1 day after TAE, reached a peak (approximately 8 times the pretreatment value) after 4 days, and remained elevated 7 days after TAE. tae 225-228 interleukin 6 Homo sapiens 72-76 8275438-5 1994 In comparison, in the patients given the drug, circulating IL-6 was at a significantly lower level at 4 and 7 days after TAE (P < 0.05, respectively). tae 121-124 interleukin 6 Homo sapiens 59-63 8206884-0 1994 Polypeptide and carbohydrate structure of recombinant human interleukin-6 produced in Chinese hamster ovary cells. Carbohydrates 16-28 interleukin 6 Homo sapiens 60-73 8206884-4 1994 However, a recombinant hIL-6 species lacking two amino acid residues (Ala-Pro) from the N-terminus was also found. alanylproline 70-77 interleukin 6 Homo sapiens 23-28 8206884-7 1994 A portion of recombinant hIL-6 protein carries one N-linked sialooligosaccharide chain, and the N-glycosylation occurs at Asn46. Nitrogen 51-52 interleukin 6 Homo sapiens 25-30 8106631-0 1994 Serum interleukin-6 in amiodarone-induced thyrotoxicosis. Amiodarone 23-33 interleukin 6 Homo sapiens 6-19 8106631-11 1994 The presence of markedly elevated serum IL-6 concentrations and low thyroidal RAIU values in patients with AIT without underlying thyroid disease suggests the presence of amiodarone-induced thyroiditis as the etiology of thyrotoxicosis. Amiodarone 171-181 interleukin 6 Homo sapiens 40-44 8202627-1 1994 In human fibroblast cultures TPA increased IL-6 and IL-8 production. Tetradecanoylphorbol Acetate 29-32 interleukin 6 Homo sapiens 43-47 8290595-4 1994 We report that, in intact cells, activation of the interleukin 6 promoter by a combination of the factor NF-IL6 and the p65 subunit of NF-kappa B is inhibited by dexamethasone (ligand)-activated glucocorticoid receptor. Dexamethasone 162-175 interleukin 6 Homo sapiens 51-64 8283061-4 1994 When KS cells were incubated with poly (I:C) in combination with either IL-1 beta or TNF-alpha, there was a synergistic increase in the level of IL-6 production, whereas LPS and TNF-alpha in combination led to only an additive increase in the level of IL-6 production. Carbon 42-43 interleukin 6 Homo sapiens 145-149 8283061-4 1994 When KS cells were incubated with poly (I:C) in combination with either IL-1 beta or TNF-alpha, there was a synergistic increase in the level of IL-6 production, whereas LPS and TNF-alpha in combination led to only an additive increase in the level of IL-6 production. Carbon 42-43 interleukin 6 Homo sapiens 252-256 8296275-5 1994 Tumour necrosis factor, IL1 and IL6 are generally produced as part of the inflammatory reaction and stimulate synthesis of prostaglandin. Prostaglandins 123-136 interleukin 6 Homo sapiens 32-35 7505212-7 1994 We also demonstrated that phorbol 12-myristate 13-acetate (PMA) or triggering of the CD28 molecule is an effective helper signal for IL-6 production by anti-CD3-stimulated T cells. Tetradecanoylphorbol Acetate 26-57 interleukin 6 Homo sapiens 133-137 7505212-7 1994 We also demonstrated that phorbol 12-myristate 13-acetate (PMA) or triggering of the CD28 molecule is an effective helper signal for IL-6 production by anti-CD3-stimulated T cells. Tetradecanoylphorbol Acetate 59-62 interleukin 6 Homo sapiens 133-137 8124729-7 1994 Cytokines, particularly interleukin-1 (IL-1) and IL-6, act as endogenous pyrogens in the brain and stimulate thermogenesis via synthesis of prostaglandins and CRF. Prostaglandins 140-154 interleukin 6 Homo sapiens 49-53 8003632-4 1994 Levels of IL-6 resulting from OM and IL-1 alpha stimulation could be reduced by indomethacin (10(-6) M) and restored again by also adding PGE2. Dinoprostone 138-142 interleukin 6 Homo sapiens 10-14 8275959-6 1994 In time-course studies, the addition of 10 ng/ml IL-1 beta significantly increased IL-6 production rates; this was first seen at 8 h of culture and increased in a linear fashion up to 48 h. At 48 h of culture, IL-6 levels were 17 times higher in treated VCMC (861 +/- 179 ng/ml) compared to those in nontreated VCMC (51 +/- 14 ng/ml). vcmc 254-258 interleukin 6 Homo sapiens 83-87 8003632-5 1994 Northern blots probed for IL-6 mRNA showed cooperative enhancement of steady state levels at 18 hours of stimulation by OM and IL-1 alpha, or OM and PGE2. Dinoprostone 149-153 interleukin 6 Homo sapiens 26-30 8275959-6 1994 In time-course studies, the addition of 10 ng/ml IL-1 beta significantly increased IL-6 production rates; this was first seen at 8 h of culture and increased in a linear fashion up to 48 h. At 48 h of culture, IL-6 levels were 17 times higher in treated VCMC (861 +/- 179 ng/ml) compared to those in nontreated VCMC (51 +/- 14 ng/ml). vcmc 254-258 interleukin 6 Homo sapiens 210-214 8275959-6 1994 In time-course studies, the addition of 10 ng/ml IL-1 beta significantly increased IL-6 production rates; this was first seen at 8 h of culture and increased in a linear fashion up to 48 h. At 48 h of culture, IL-6 levels were 17 times higher in treated VCMC (861 +/- 179 ng/ml) compared to those in nontreated VCMC (51 +/- 14 ng/ml). vcmc 311-315 interleukin 6 Homo sapiens 83-87 8275959-6 1994 In time-course studies, the addition of 10 ng/ml IL-1 beta significantly increased IL-6 production rates; this was first seen at 8 h of culture and increased in a linear fashion up to 48 h. At 48 h of culture, IL-6 levels were 17 times higher in treated VCMC (861 +/- 179 ng/ml) compared to those in nontreated VCMC (51 +/- 14 ng/ml). vcmc 311-315 interleukin 6 Homo sapiens 210-214 8275959-7 1994 In summary, IL-1 beta stimulates VCMC IL-6 production in a specific dose- and time-dependent manner. vcmc 33-37 interleukin 6 Homo sapiens 38-42 8275959-8 1994 From these results, we conclude that VCMC are an important source of IL-6 in second trimester placenta and that production of placental IL-6 be may regulated by decidual IL-1 beta. vcmc 37-41 interleukin 6 Homo sapiens 69-73 7919430-0 1994 Serum interleukin-6 levels as an early marker of therapeutic response to UVB radiation and topical steroids in psoriatic patients. Steroids 99-107 interleukin 6 Homo sapiens 6-19 8181840-8 1994 Both IL-6 and TNF alpha not only enhance neutrophil activation, but also stimulate an adhesive neutrophil-cardiac myocyte interaction which is associated with the release of toxic oxygen radicals. Reactive Oxygen Species 180-195 interleukin 6 Homo sapiens 5-9 18475583-0 1994 FK506 and Cyclosporin A Enhance IL-6 Production in Monocytes: A single-Cell Assay. Cyclosporine 10-23 interleukin 6 Homo sapiens 32-36 18475583-1 1994 The effect of FK506 and cyclosporin A (CsA) on the production of interleukin 6 (IL-6) in adherent monocytes was studied at a single-cell level by the avidinbiotin- peroxidase complex methods. Cyclosporine 24-37 interleukin 6 Homo sapiens 65-78 18475583-1 1994 The effect of FK506 and cyclosporin A (CsA) on the production of interleukin 6 (IL-6) in adherent monocytes was studied at a single-cell level by the avidinbiotin- peroxidase complex methods. Cyclosporine 24-37 interleukin 6 Homo sapiens 80-84 7696968-6 1994 After tyrosine specific phosphorylation of APRF, it translocates into nuclei, binds to type 2 IL-6 responsive element and induces acute phase gene expression. Tyrosine 6-14 interleukin 6 Homo sapiens 94-98 7991018-8 1994 The higher the IL-6 overexpression, the higher was the rate of steroid resistance with focal sclerosis. Steroids 63-70 interleukin 6 Homo sapiens 15-19 7885789-0 1994 Urine interleukin-6 and interleukin-8 in children with acute pyelonephritis, in relation to DMSA scintigraphy in the acute phase and at 1-year follow-up. Technetium Tc 99m Dimercaptosuccinic Acid 92-96 interleukin 6 Homo sapiens 6-19 7885789-2 1994 The urine IL-6 and IL-8/creatinine quotients were also related to the urine N-acetyl-beta-D-glucosaminidase (NAG) and albumin/creatinine quotients. Creatinine 126-136 interleukin 6 Homo sapiens 10-14 7885789-3 1994 Presence of DMSA uptake defects, reflecting local inflammation, in children in the acute phase of pyelonephritis, were associated with elevated urine IL-6/creatinine quotients (median 27 pg/mumol); in children without DMSA changes there was no increase in quotients (median non-detectable) (P < 0.05). Technetium Tc 99m Dimercaptosuccinic Acid 12-16 interleukin 6 Homo sapiens 150-154 7885789-3 1994 Presence of DMSA uptake defects, reflecting local inflammation, in children in the acute phase of pyelonephritis, were associated with elevated urine IL-6/creatinine quotients (median 27 pg/mumol); in children without DMSA changes there was no increase in quotients (median non-detectable) (P < 0.05). Technetium Tc 99m Dimercaptosuccinic Acid 218-222 interleukin 6 Homo sapiens 150-154 7885789-4 1994 Persistent DMSA changes at the 1-year follow-up, probably reflecting renal scarring, were only seen in children with increased urine IL-6/creatinine quotients in the acute phase (P < 0.01). Technetium Tc 99m Dimercaptosuccinic Acid 11-15 interleukin 6 Homo sapiens 133-137 8258686-4 1993 Our study demonstrated that IL-2, IL-4, and IL-6-stimulation of IgM secretion by SKW6.4 cells was inhibited by either the serine/threonine kinase inhibitor, 1-(5-isoquinolinesulfonyl)-2-methylpiperizine dihydrochloride (H7) or the tyrosine kinase inhibitor, genistein. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 220-222 interleukin 6 Homo sapiens 44-48 11271305-0 1994 Effect of immunosuppressive agents FK 506 and cyclosporin and steroids on the expression of IL-6 and its receptor by stimulated lymphocytes and monocytes. Cyclosporine 46-57 interleukin 6 Homo sapiens 92-96 11271305-0 1994 Effect of immunosuppressive agents FK 506 and cyclosporin and steroids on the expression of IL-6 and its receptor by stimulated lymphocytes and monocytes. Steroids 62-70 interleukin 6 Homo sapiens 92-96 11271305-5 1994 Dexamethazone, cyclosporin (CyA), and FK 506 at immunosuppressive concentrations induced a dose-dependent inhibition of IL-6 secretion from adherent monocytes (MO) stimulated with phytohemagglutinin (PHA). Dexamethasone 0-13 interleukin 6 Homo sapiens 120-124 11271305-5 1994 Dexamethazone, cyclosporin (CyA), and FK 506 at immunosuppressive concentrations induced a dose-dependent inhibition of IL-6 secretion from adherent monocytes (MO) stimulated with phytohemagglutinin (PHA). Cyclosporine 15-26 interleukin 6 Homo sapiens 120-124 11271305-5 1994 Dexamethazone, cyclosporin (CyA), and FK 506 at immunosuppressive concentrations induced a dose-dependent inhibition of IL-6 secretion from adherent monocytes (MO) stimulated with phytohemagglutinin (PHA). Cyclosporine 28-31 interleukin 6 Homo sapiens 120-124 11271305-6 1994 Dexamethazone was the most effective agent in inhibiting IL-6 secretion, while the inhibitory effect observed with 1 ng/ml FK 506 was comparable with that obtained with 100 ng/ml CyA. Dexamethasone 0-13 interleukin 6 Homo sapiens 57-61 11271305-12 1994 FK 506, CyA, and steroids may exert their immunosuppressive effect by inhibiting IL-6 secretion and partially restoring MO IL-6R, which may be important in protecting the cell target against IL-6 autocrine stimulation. Steroids 17-25 interleukin 6 Homo sapiens 81-85 11271305-12 1994 FK 506, CyA, and steroids may exert their immunosuppressive effect by inhibiting IL-6 secretion and partially restoring MO IL-6R, which may be important in protecting the cell target against IL-6 autocrine stimulation. Steroids 17-25 interleukin 6 Homo sapiens 123-127 8258686-6 1993 IL-2, IL-4, and IL-6 stimulated the rapid serine/threonine phosphorylation of 47-, 49-, and 91-kDa proteins. Serine 42-48 interleukin 6 Homo sapiens 16-20 8258686-6 1993 IL-2, IL-4, and IL-6 stimulated the rapid serine/threonine phosphorylation of 47-, 49-, and 91-kDa proteins. Threonine 49-58 interleukin 6 Homo sapiens 16-20 8258686-8 1993 The observation that serine/threonine phosphorylation of the same proteins was stimulated by IL-2, IL-4, and IL-6 suggested that the cytokines activated either different protein kinases with the same substrate specificity or the same protein kinase. Serine 21-27 interleukin 6 Homo sapiens 109-113 8258686-8 1993 The observation that serine/threonine phosphorylation of the same proteins was stimulated by IL-2, IL-4, and IL-6 suggested that the cytokines activated either different protein kinases with the same substrate specificity or the same protein kinase. Threonine 28-37 interleukin 6 Homo sapiens 109-113 8243566-0 1993 Effect of combined treatment with interleukin-3 and interleukin-6 on 4-hydroperoxycyclo-phosphamide-induced programmed cell death or apoptosis in human myeloid leukemia cells. perfosfamide 69-99 interleukin 6 Homo sapiens 52-65 8116830-2 1993 This study was designed to investigate the relationship between chronic alcohol ingestion and cessation with respect to release of interleukin-6 (IL-6) and interleukin-8 (IL-8) using highly specific and sensitive ELISA assays, as well as a functional assay, natural killer cell cytotoxic activity. Alcohols 72-79 interleukin 6 Homo sapiens 131-144 8116830-2 1993 This study was designed to investigate the relationship between chronic alcohol ingestion and cessation with respect to release of interleukin-6 (IL-6) and interleukin-8 (IL-8) using highly specific and sensitive ELISA assays, as well as a functional assay, natural killer cell cytotoxic activity. Alcohols 72-79 interleukin 6 Homo sapiens 146-150 8243566-5 1993 A combined treatment with interleukin-3 (IL-3) plus IL-6 for 18 hours before an additional, 1-hour concurrent treatment with 4-HC (100 microM/L) significantly increased 4-HC-induced DNA fragmentation as well as colony growth inhibition of HL60 cells. perfosfamide 169-173 interleukin 6 Homo sapiens 52-56 8186370-6 1993 Using digoxigenin-labelled oligonucleotide probes we have detected expression of the cytokines IL-1 alpha, IL-2, IL-4, IL-6, IL-10, IFN-gamma, TGF beta 1 & 2 and TNF-alpha in frozen sections of CNS tissue from MS cases. Oligonucleotides 27-42 interleukin 6 Homo sapiens 119-123 8263160-0 1993 Association between serum interleukin-6 and serum 3,5,3"-triiodothyronine in nonthyroidal illness. 3,5,3"-triiodothyronine 50-73 interleukin 6 Homo sapiens 26-39 8403558-0 1993 Hydrocortisone regulation of interleukin-6 protein production by a purified population of human peripheral blood monocytes. Hydrocortisone 0-14 interleukin 6 Homo sapiens 29-42 8403558-1 1993 The direct effect of the endogenous glucocorticoid (GC) hydrocortisone (HC) on interleukin-6 (IL-6) production was examined using purified populations of human peripheral blood monocytes (Mo). Hydrocortisone 56-70 interleukin 6 Homo sapiens 79-92 8403558-1 1993 The direct effect of the endogenous glucocorticoid (GC) hydrocortisone (HC) on interleukin-6 (IL-6) production was examined using purified populations of human peripheral blood monocytes (Mo). Hydrocortisone 56-70 interleukin 6 Homo sapiens 94-98 8403558-8 1993 The EC50 of LPS-induced IL-6 production by HC was 2.0 x 10(-7) M. The inhibitory effect of HC on LPS-stimulated IL-6 production was GC specific and receptor mediated because: (i) equivalent inhibition was not observed with other endogenous steroids and (ii) equimolar amounts of the GC antagonist RU 486 blocked the GC-mediated effect. Steroids 240-248 interleukin 6 Homo sapiens 24-28 7507316-6 1993 For instance, CsA and FK 506 inhibit the transcription of IL-3, IL-4, IFN gamma, TNF alpha or GM-CSF by activated T cells, and rapamycin has been shown to block the response to various growth factors such as IL-3, IL-4 or IL-6. Cyclosporine 14-17 interleukin 6 Homo sapiens 222-226 7507316-6 1993 For instance, CsA and FK 506 inhibit the transcription of IL-3, IL-4, IFN gamma, TNF alpha or GM-CSF by activated T cells, and rapamycin has been shown to block the response to various growth factors such as IL-3, IL-4 or IL-6. Sirolimus 127-136 interleukin 6 Homo sapiens 222-226 8403558-8 1993 The EC50 of LPS-induced IL-6 production by HC was 2.0 x 10(-7) M. The inhibitory effect of HC on LPS-stimulated IL-6 production was GC specific and receptor mediated because: (i) equivalent inhibition was not observed with other endogenous steroids and (ii) equimolar amounts of the GC antagonist RU 486 blocked the GC-mediated effect. Steroids 240-248 interleukin 6 Homo sapiens 112-116 7908745-5 1993 There were significant correlations between plasma L-TRP levels, on the one hand, and Tf plasma levels, DPP IV activity (both positive), Il-6 production, and Hp plasma levels (both negative), on the other. Tryptophan 51-56 interleukin 6 Homo sapiens 137-141 8240983-0 1993 The anti-estrogen tamoxifen blocks the stimulatory effects of interleukin-6 on 17 beta-hydroxysteroid dehydrogenase activity in MCF-7 cells. Tamoxifen 18-27 interleukin 6 Homo sapiens 62-75 8240983-1 1993 Previous studies have revealed that human breast fibroblasts secrete the cytokine, interleukin-6 (IL-6) which stimulates the ability of MCF-7 human breast carcinoma cells to convert estrone (E1) to the biologically more active 17 beta-estradiol (E2). Estradiol 230-244 interleukin 6 Homo sapiens 83-96 8240983-1 1993 Previous studies have revealed that human breast fibroblasts secrete the cytokine, interleukin-6 (IL-6) which stimulates the ability of MCF-7 human breast carcinoma cells to convert estrone (E1) to the biologically more active 17 beta-estradiol (E2). Estradiol 230-244 interleukin 6 Homo sapiens 98-102 8240983-6 1993 IL-6 is most likely acting through an E2-dependent mechanism, since tamoxifen completely reversed the effects of E2 and IL-6 separately and in combination. Tamoxifen 68-77 interleukin 6 Homo sapiens 0-4 8240983-6 1993 IL-6 is most likely acting through an E2-dependent mechanism, since tamoxifen completely reversed the effects of E2 and IL-6 separately and in combination. Tamoxifen 68-77 interleukin 6 Homo sapiens 120-124 8240983-7 1993 These observations suggest that tamoxifen may reduce intratissular levels of E2 by directly increasing oxidative 17-HSD activity and by blocking the actions of paracrine factors such as IL-6 which increase reductive 17-HSD activity. Tamoxifen 32-41 interleukin 6 Homo sapiens 186-190 7908745-6 1993 Up to 63.7% of the variance in L-TRP plasma concentrations could be explained by DPP IV, Hp, Il-6 values, and gender. Tryptophan 31-36 interleukin 6 Homo sapiens 93-97 7691110-9 1993 Rhamnolipids and MEP were found to stimulate the copious release of IL-8, GM-CSF, and IL-6 from epithelial cells, in a steroid-sensitive fashion. Steroids 119-126 interleukin 6 Homo sapiens 86-90 8408066-4 1993 Surprisingly, IL-6 carrying a COOH-terminal extension of the amino acids Lys-Asp-Glu-Leu (KDEL) was not completely retained in the endoplasmic reticulum (ER). Carbonic Acid 30-34 interleukin 6 Homo sapiens 14-18 7694480-3 1993 In particular, we assessed whether dexamethasone was capable of inhibiting the tumor necrosis factor-alpha (TNF-alpha)-mediated secretion of interleukin-6 (IL-6), interleukin-8 (IL-8), and granulocyte colony-stimulating factor (G-CSF) by a human bronchial epithelial cell line (BEAS-2B). Dexamethasone 35-48 interleukin 6 Homo sapiens 141-154 7694480-3 1993 In particular, we assessed whether dexamethasone was capable of inhibiting the tumor necrosis factor-alpha (TNF-alpha)-mediated secretion of interleukin-6 (IL-6), interleukin-8 (IL-8), and granulocyte colony-stimulating factor (G-CSF) by a human bronchial epithelial cell line (BEAS-2B). Dexamethasone 35-48 interleukin 6 Homo sapiens 156-160 7694480-6 1993 Dexamethasone preconditioning significantly inhibited both the secretion of immunoreactive IL-6 and the accumulation of IL-6 mRNA. Dexamethasone 0-13 interleukin 6 Homo sapiens 91-95 7694480-6 1993 Dexamethasone preconditioning significantly inhibited both the secretion of immunoreactive IL-6 and the accumulation of IL-6 mRNA. Dexamethasone 0-13 interleukin 6 Homo sapiens 120-124 8286511-5 1993 MAIN OUTCOME MEASURES: Effect of TNF-alpha, interleukin-1 (IL-1), and interleukin-6 (IL-6) on the synthesis of triacylglycerol and phospholipids by freshly isolated human hepatocytes. Phospholipids 131-144 interleukin 6 Homo sapiens 85-89 8286509-8 1993 The preoperative APACHE II score correlated with the increased TNF alpha concentration (r = 0.5, p < 0.001) and plasma lactate concentration with that of IL-6 (r = 0.7, p = 0.003). Lactic Acid 122-129 interleukin 6 Homo sapiens 157-161 8286511-5 1993 MAIN OUTCOME MEASURES: Effect of TNF-alpha, interleukin-1 (IL-1), and interleukin-6 (IL-6) on the synthesis of triacylglycerol and phospholipids by freshly isolated human hepatocytes. Triglycerides 111-126 interleukin 6 Homo sapiens 70-83 8397445-3 1993 Epidermal growth factor, interferon-gamma, and interleukin-6 all activated, through direct tyrosine phosphorylation, latent cytoplasmic transcription factors that recognized similar DNA elements. Tyrosine 91-99 interleukin 6 Homo sapiens 47-60 8286511-5 1993 MAIN OUTCOME MEASURES: Effect of TNF-alpha, interleukin-1 (IL-1), and interleukin-6 (IL-6) on the synthesis of triacylglycerol and phospholipids by freshly isolated human hepatocytes. Triglycerides 111-126 interleukin 6 Homo sapiens 85-89 8286511-5 1993 MAIN OUTCOME MEASURES: Effect of TNF-alpha, interleukin-1 (IL-1), and interleukin-6 (IL-6) on the synthesis of triacylglycerol and phospholipids by freshly isolated human hepatocytes. Phospholipids 131-144 interleukin 6 Homo sapiens 70-83 8276774-7 1993 Furthermore, by the gel mobility shift assay using anti-hsp70 antibody, the association of copper- and zinc-activated HSF with hsp70 was observed in both NT and TT cells. Copper 91-97 interleukin 6 Homo sapiens 118-121 8397259-15 1993 These findings suggest that IL-6 down-modulates cytokine activation of M phi antileishmanial capacity by inhibiting oxygen-dependent and undefined oxygen-independent mechanisms. Oxygen 116-122 interleukin 6 Homo sapiens 28-32 8397259-15 1993 These findings suggest that IL-6 down-modulates cytokine activation of M phi antileishmanial capacity by inhibiting oxygen-dependent and undefined oxygen-independent mechanisms. Oxygen 147-153 interleukin 6 Homo sapiens 28-32 8248548-0 1993 Effects of interleukin-6 and tumor necrosis factor-alpha on prostaglandin production by cultured human fetal membranes. Prostaglandins 60-73 interleukin 6 Homo sapiens 11-24 8248548-1 1993 In this study we investigated the effects of the cytokines interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) on prostaglandin production by cultured human fetal membranes. Prostaglandins 127-140 interleukin 6 Homo sapiens 59-72 8248548-1 1993 In this study we investigated the effects of the cytokines interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) on prostaglandin production by cultured human fetal membranes. Prostaglandins 127-140 interleukin 6 Homo sapiens 74-78 8248548-5 1993 The addition of IL-6 to the fetal or the maternal side of the membrane increased production of PGE2 from amnion and PGE2m from chorion, suggesting that IL-6 might pass through the fetal membrane. Dinoprostone 95-99 interleukin 6 Homo sapiens 16-20 8248548-5 1993 The addition of IL-6 to the fetal or the maternal side of the membrane increased production of PGE2 from amnion and PGE2m from chorion, suggesting that IL-6 might pass through the fetal membrane. Dinoprostone 116-120 interleukin 6 Homo sapiens 16-20 8248548-5 1993 The addition of IL-6 to the fetal or the maternal side of the membrane increased production of PGE2 from amnion and PGE2m from chorion, suggesting that IL-6 might pass through the fetal membrane. Dinoprostone 116-120 interleukin 6 Homo sapiens 152-156 8219478-7 1993 IL-6 was increased by GH and IGF-I, and lowered by 1,25(OH)2D3 and supraphysiological doses of 17 beta-oestradiol, while PTH(1-34) had no effects. Estradiol 95-113 interleukin 6 Homo sapiens 0-4 8355691-5 1993 HSF activation in response to treatment with sodium arsenite or the proline analog azetidine was also depressed in hsp70-expressing cells relative to that in the nontransfected control cells. azetidine 83-92 interleukin 6 Homo sapiens 0-3 8245177-3 1993 IL-6 synthesis in HEp-2 cells was induced by IL-1, PMA, and calcium ionophore A 23187 but not by dibutyryl-cAMP. Calcium 60-67 interleukin 6 Homo sapiens 0-4 8245177-5 1993 PMA pretreatment of HEp-2 cells abolished PMA-induced IL-6 but the IL-1 effect was not reduced. Tetradecanoylphorbol Acetate 0-3 interleukin 6 Homo sapiens 54-58 8365378-7 1993 Stimulation by interleukin-6 (IL-6; 200 U/ml), epidermal growth factor (4 nM), and estradiol (10(-7) M) was 2- to 3-fold, whereas stimulations by tetradecanoylphorbol-13-acetate (TPA; 80 nM) and IL-1 (10 U/ml) were 2- to 5-fold and 5- to 10-fold, respectively. Tetradecanoylphorbol Acetate 179-182 interleukin 6 Homo sapiens 15-28 8360477-5 1993 The results showed that IL-11 and IL-6 can both stimulate cell proliferation, induce similar pattern of protein tyrosine phosphorylation, and activate the same proto-oncogene (junB) expression in TF-1 cells. Tyrosine 112-120 interleukin 6 Homo sapiens 34-38 8356399-3 1993 We found that hydrocortisone stimulated cell proliferation but inhibited the differentiation of TEC and significantly reduced the production of interleukin-1 alpha, interleukin-6 and granulocyte-macrophage colony stimulating factor. Hydrocortisone 14-28 interleukin 6 Homo sapiens 165-178 8356404-0 1993 Up-regulation by cyclosporine (CsA) of the in vitro release of soluble CD23 (sCD23) and of the in vitro production of IL-6 and IgM. Cyclosporine 17-29 interleukin 6 Homo sapiens 118-122 8356404-0 1993 Up-regulation by cyclosporine (CsA) of the in vitro release of soluble CD23 (sCD23) and of the in vitro production of IL-6 and IgM. Cyclosporine 31-34 interleukin 6 Homo sapiens 118-122 8356404-4 1993 CsA down-regulated the IL-2/IL-6-induced proliferative responses of pre-activated B cells by at least 50%, but it up-regulated IgM production in the same experiments. Cyclosporine 0-3 interleukin 6 Homo sapiens 28-32 8356404-7 1993 Finally, CsA was shown to inhibit PHA-induced cell proliferation of PBMC and to up-regulate IL-6 production in the same cultures. Cyclosporine 9-12 interleukin 6 Homo sapiens 92-96 8356404-9 1993 This finding, in combination with the CsA-induced up-regulation of lectin-induced IL-6 production, may have clinical implications in disease states with an ongoing immune activation, where prolonged administration of CsA might be anticipated. Cyclosporine 38-41 interleukin 6 Homo sapiens 82-86 8356404-9 1993 This finding, in combination with the CsA-induced up-regulation of lectin-induced IL-6 production, may have clinical implications in disease states with an ongoing immune activation, where prolonged administration of CsA might be anticipated. Cyclosporine 217-220 interleukin 6 Homo sapiens 82-86 8401220-0 1993 An ATP- and hsc70-dependent oligomerization of nascent heat-shock factor (HSF) polypeptide suggests that HSF itself could be a "sensor" for the cellular stress response. Adenosine Triphosphate 3-6 interleukin 6 Homo sapiens 55-72 8365410-10 1993 When 125I-IL-6 was chemically cross-linked to the purified srhIL-6R and analyzed by SDS/PAGE, several 125I-IL-6-containing bands were detected, indicating the possible existence of a multimeric structure of the natural IL-6/IL-6R complex. Sodium Dodecyl Sulfate 84-87 interleukin 6 Homo sapiens 10-14 8365410-10 1993 When 125I-IL-6 was chemically cross-linked to the purified srhIL-6R and analyzed by SDS/PAGE, several 125I-IL-6-containing bands were detected, indicating the possible existence of a multimeric structure of the natural IL-6/IL-6R complex. Sodium Dodecyl Sulfate 84-87 interleukin 6 Homo sapiens 62-66 8365410-10 1993 When 125I-IL-6 was chemically cross-linked to the purified srhIL-6R and analyzed by SDS/PAGE, several 125I-IL-6-containing bands were detected, indicating the possible existence of a multimeric structure of the natural IL-6/IL-6R complex. Sodium Dodecyl Sulfate 84-87 interleukin 6 Homo sapiens 62-66 8354288-5 1993 This complex was stable in SDS and 2-mercaptoethanol at 100 degrees C and was not dissociated by hydroxylamine treatment, indicating the formation of a covalent non-ester bond between the 8-kDa 125I-IL-6-derived peptide and an undetermined acceptor. Sodium Dodecyl Sulfate 27-30 interleukin 6 Homo sapiens 199-203 8354288-6 1993 An initial oxidative treatment of 125I-IL-6 partially prevented complex formation, suggesting the presence of one or more oxidizable methionine residues at the binding site of 8-kDa 125I-IL-6 peptide. Methionine 133-143 interleukin 6 Homo sapiens 39-43 8354288-6 1993 An initial oxidative treatment of 125I-IL-6 partially prevented complex formation, suggesting the presence of one or more oxidizable methionine residues at the binding site of 8-kDa 125I-IL-6 peptide. Methionine 133-143 interleukin 6 Homo sapiens 187-191 7688764-10 1993 However, r.IL-6 did stimulate tyrosine phosphorylation and p42MAPK activity in the human B cell line, AF-10, while OSM and LIF exerted no effects. Tyrosine 30-38 interleukin 6 Homo sapiens 11-15 8360592-4 1993 RA differentially modulated the expression of interleukin-1 beta (IL-1 beta), IL-6, and IL-8 mRNAs depending on the inducing stimulus. Tretinoin 0-2 interleukin 6 Homo sapiens 78-82 8360592-5 1993 While phorbol myristate acetate-induced IL-1 beta and IL-8 mRNA expression was increased by RA (IL-6 could not be induced by this pathway in monocytes), IL-1 beta-induced expression of IL-1 beta and IL-8 was markedly reduced and IL-6 gene expression was almost completely suppressed. Tetradecanoylphorbol Acetate 6-31 interleukin 6 Homo sapiens 96-100 8360592-5 1993 While phorbol myristate acetate-induced IL-1 beta and IL-8 mRNA expression was increased by RA (IL-6 could not be induced by this pathway in monocytes), IL-1 beta-induced expression of IL-1 beta and IL-8 was markedly reduced and IL-6 gene expression was almost completely suppressed. Tetradecanoylphorbol Acetate 6-31 interleukin 6 Homo sapiens 229-233 8360592-7 1993 IL-1-induced de novo synthesis of IL-6 protein and secretion of biologically active IL-6 were also inhibited by RA. Tretinoin 112-114 interleukin 6 Homo sapiens 34-38 8360592-7 1993 IL-1-induced de novo synthesis of IL-6 protein and secretion of biologically active IL-6 were also inhibited by RA. Tretinoin 112-114 interleukin 6 Homo sapiens 84-88 8344757-12 1993 Dexamethasone suppressed the release of IL-6, but had no inhibitory effect on IL-10 secretion. Dexamethasone 0-13 interleukin 6 Homo sapiens 40-44 8398910-3 1993 It is reported here that IL-6 elevated the junB and c-jun mRNA levels and induced the formation of a novel DNA-protein complex with high sequence specificity to 12-O-tetradecanoylphorbol-13-acetate response element (TRE) oligonucleotides. Tetradecanoylphorbol Acetate 161-197 interleukin 6 Homo sapiens 25-29 8398910-3 1993 It is reported here that IL-6 elevated the junB and c-jun mRNA levels and induced the formation of a novel DNA-protein complex with high sequence specificity to 12-O-tetradecanoylphorbol-13-acetate response element (TRE) oligonucleotides. Oligonucleotides 221-237 interleukin 6 Homo sapiens 25-29 8393800-4 1993 This induction of IL-6 production could be achieved by reagents known to increase intracellular levels of cAMP, such as forskolin, prostaglandin E or pentoxifylline. Cyclic AMP 106-110 interleukin 6 Homo sapiens 18-22 8393800-8 1993 Our results indicate that HTLV-1 tax induces hyperproduction of IL-6 in brain-specific endothelial cells directly by an intracellular mechanism which subsequently renders IL-6 production independent of exogenous stimuli or activators of (cAMP-dependent) second messenger levels. Cyclic AMP 238-242 interleukin 6 Homo sapiens 64-68 8401220-0 1993 An ATP- and hsc70-dependent oligomerization of nascent heat-shock factor (HSF) polypeptide suggests that HSF itself could be a "sensor" for the cellular stress response. Adenosine Triphosphate 3-6 interleukin 6 Homo sapiens 74-77 8401220-0 1993 An ATP- and hsc70-dependent oligomerization of nascent heat-shock factor (HSF) polypeptide suggests that HSF itself could be a "sensor" for the cellular stress response. Adenosine Triphosphate 3-6 interleukin 6 Homo sapiens 105-108 8322772-4 1993 Peak LPS-induced production of TNF-alpha, IL-1 beta, and IL-6 by monocytes from patients on peritoneal dialysis and cellulose ester hemodialysis was less than that by monocytes from healthy controls. cellulose ester 116-131 interleukin 6 Homo sapiens 57-61 7684660-5 1993 IL-3, IL-5, IL-6, and GM-CSF enhanced significantly anti-IgE- and FMLP-induced histamine release. Histamine 79-88 interleukin 6 Homo sapiens 12-16 8511589-2 1993 Binding of IL-6 to IL-6R induced disulfide-linked homodimerization of gp130. Disulfides 33-42 interleukin 6 Homo sapiens 11-15 8099851-2 1993 Interferon-gamma, interleukin-1, and interleukin-6 significantly increased adhesion; however, the highest adhesive response was obtained when cocultures were treated with phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 171-196 interleukin 6 Homo sapiens 37-50 8099851-2 1993 Interferon-gamma, interleukin-1, and interleukin-6 significantly increased adhesion; however, the highest adhesive response was obtained when cocultures were treated with phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 198-201 interleukin 6 Homo sapiens 37-50 8391424-4 1993 When Hep G2 cells were exposed to different concentrations of IL-6 for variable time intervals, IL-6 caused a dose- and time-dependent decrease in the amount of [35S]methionine-labeled CBG immunoprecipitated in the culture medium. Sulfur-35 162-165 interleukin 6 Homo sapiens 62-66 8391424-4 1993 When Hep G2 cells were exposed to different concentrations of IL-6 for variable time intervals, IL-6 caused a dose- and time-dependent decrease in the amount of [35S]methionine-labeled CBG immunoprecipitated in the culture medium. Sulfur-35 162-165 interleukin 6 Homo sapiens 96-100 8391424-4 1993 When Hep G2 cells were exposed to different concentrations of IL-6 for variable time intervals, IL-6 caused a dose- and time-dependent decrease in the amount of [35S]methionine-labeled CBG immunoprecipitated in the culture medium. Methionine 166-176 interleukin 6 Homo sapiens 62-66 8391424-4 1993 When Hep G2 cells were exposed to different concentrations of IL-6 for variable time intervals, IL-6 caused a dose- and time-dependent decrease in the amount of [35S]methionine-labeled CBG immunoprecipitated in the culture medium. Methionine 166-176 interleukin 6 Homo sapiens 96-100 8391424-10 1993 In view of the role of IL-6 in the inflammatory process and other acute phase phenomena, these data suggest that its effects on CBG synthesis might influence the bioavailability of cortisol indirectly and play a role in regulating the homeostatic process during these conditions. Hydrocortisone 181-189 interleukin 6 Homo sapiens 23-27 8393337-1 1993 It has been demonstrated that reductive 17 beta-hydroxysteroid dehydrogenase activity (17-HSD) in the human breast cancer cell line MCF-7 can be stimulated by 17 beta-estradiol (E2), progesterone (P) and interleukin-6 (IL-6). Estradiol 159-176 interleukin 6 Homo sapiens 204-217 8393337-1 1993 It has been demonstrated that reductive 17 beta-hydroxysteroid dehydrogenase activity (17-HSD) in the human breast cancer cell line MCF-7 can be stimulated by 17 beta-estradiol (E2), progesterone (P) and interleukin-6 (IL-6). Estradiol 159-176 interleukin 6 Homo sapiens 219-223 8393337-1 1993 It has been demonstrated that reductive 17 beta-hydroxysteroid dehydrogenase activity (17-HSD) in the human breast cancer cell line MCF-7 can be stimulated by 17 beta-estradiol (E2), progesterone (P) and interleukin-6 (IL-6). Progesterone 183-195 interleukin 6 Homo sapiens 204-217 8393337-1 1993 It has been demonstrated that reductive 17 beta-hydroxysteroid dehydrogenase activity (17-HSD) in the human breast cancer cell line MCF-7 can be stimulated by 17 beta-estradiol (E2), progesterone (P) and interleukin-6 (IL-6). Progesterone 183-195 interleukin 6 Homo sapiens 219-223 8393337-3 1993 E2 stimulated growth of MCF-7 cells in a dose-dependent manner, while IL-6 had a growth inhibitory effect and in combination with E2, it reduced or abolished the stimulatory effects of the steroid. Steroids 189-196 interleukin 6 Homo sapiens 70-74 7685949-0 1993 Effect of FK 506 and cyclosporine on the expression of IL-6 and its receptor on stimulated monocytes. Cyclosporine 21-33 interleukin 6 Homo sapiens 55-59 8345065-8 1993 Addition of steroids to the media stimulated the production of IL6 by cells from proliferative and early secretory endometrium but decreased IL6 production from cells in the late secretory phase. Steroids 12-20 interleukin 6 Homo sapiens 63-66 8345065-8 1993 Addition of steroids to the media stimulated the production of IL6 by cells from proliferative and early secretory endometrium but decreased IL6 production from cells in the late secretory phase. Steroids 12-20 interleukin 6 Homo sapiens 141-144 8101242-7 1993 Steroid hormone significantly reduced IL-6 production by PBMNC, but others had no effect on IL-6 production. Steroids 0-15 interleukin 6 Homo sapiens 38-42 8101242-7 1993 Steroid hormone significantly reduced IL-6 production by PBMNC, but others had no effect on IL-6 production. pbmnc 57-62 interleukin 6 Homo sapiens 38-42 8344702-0 1993 Effect of retinoic acid and vitamin D on the expression of interleukin-1 beta, tumour necrosis factor-alpha and interleukin-6 in the human monocytic cell line U937. Tretinoin 10-23 interleukin 6 Homo sapiens 112-125 8344702-0 1993 Effect of retinoic acid and vitamin D on the expression of interleukin-1 beta, tumour necrosis factor-alpha and interleukin-6 in the human monocytic cell line U937. Vitamin D 28-37 interleukin 6 Homo sapiens 112-125 8485909-2 1993 A strong hybridization signal for the IL-6 probe was observed in mRNA extracted from phytohaemagglutinin (PHA)- and PHA/phorbol myristate acetate (PMA)-stimulated PBMC from most of 12 CVI patients analysed. Tetradecanoylphorbol Acetate 120-145 interleukin 6 Homo sapiens 38-42 8218938-4 1993 On the other hand, IL-6 stimulated production of active oxygen molecules and ADCC of the cells treated with VD3 and tumor necrosis factor-alpha (TNF-alpha). Oxygen 56-62 interleukin 6 Homo sapiens 19-23 8485909-2 1993 A strong hybridization signal for the IL-6 probe was observed in mRNA extracted from phytohaemagglutinin (PHA)- and PHA/phorbol myristate acetate (PMA)-stimulated PBMC from most of 12 CVI patients analysed. Tetradecanoylphorbol Acetate 147-150 interleukin 6 Homo sapiens 38-42 8476047-0 1993 Prostaglandin E2 downregulates Kupffer cell production of IL-1 and IL-6 during hepatic regeneration. Dinoprostone 0-16 interleukin 6 Homo sapiens 67-71 8386318-1 1993 Interleukin-6 (IL-6) activation of the immediate-early gene junB has been shown to require both a tyrosine kinase and an unknown 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H7)-sensitive pathway. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 129-174 interleukin 6 Homo sapiens 0-13 8386318-1 1993 Interleukin-6 (IL-6) activation of the immediate-early gene junB has been shown to require both a tyrosine kinase and an unknown 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H7)-sensitive pathway. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 129-174 interleukin 6 Homo sapiens 15-19 8386318-1 1993 Interleukin-6 (IL-6) activation of the immediate-early gene junB has been shown to require both a tyrosine kinase and an unknown 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H7)-sensitive pathway. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 176-178 interleukin 6 Homo sapiens 0-13 8386318-1 1993 Interleukin-6 (IL-6) activation of the immediate-early gene junB has been shown to require both a tyrosine kinase and an unknown 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H7)-sensitive pathway. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 176-178 interleukin 6 Homo sapiens 15-19 8386028-7 1993 In single patients cultivation of monocytes with IL-6 and granulocyte-macrophage colony-stimulating factor resulted in only slight improvement of superoxide production. Superoxides 146-156 interleukin 6 Homo sapiens 49-53 8475996-9 1993 These results showed that GMC from localized inflammatory tissues in severe stages of AP possess a distinct cytokine profile represented by high levels of IL-5 and IL-6 mRNA expression and protein synthesis, whereas IL-2 and IL-4 were not detected. Puromycin aminonucleoside 26-29 interleukin 6 Homo sapiens 164-168 8096510-3 1993 Dexamethasone strengthened the stimulation by IL-6. Dexamethasone 0-13 interleukin 6 Homo sapiens 46-50 8476047-9 1993 We conclude that during hepatic regeneration, KC IL-1 and IL-6 production is elevated and is controlled in an autoregulatory fashion by elevated KC PGE2 production. Dinoprostone 148-152 interleukin 6 Homo sapiens 58-62 8476047-5 1993 This enhancement of regenerating liver KC to produce IL-1 and IL-6 was increased (P < 0.05) by placing these same KC in 10 microM arginine RPMI 1640 culture media. Arginine 133-141 interleukin 6 Homo sapiens 62-66 8476047-8 1993 When the cyclooxygenase inhibitor indomethacin (10 microM) was added to cultures, the production of PGE2 by KC was prevented, and in arginine-depleted cultures, IL-1 and IL-6 production was upregulated (P < 0.05). Arginine 133-141 interleukin 6 Homo sapiens 170-174 8458386-5 1993 A requirement for IL-6 in responses of unfractionated TMC may have been disguised by the presence of T cells. tmc 54-57 interleukin 6 Homo sapiens 18-22 8453620-5 1993 IL-1 and IL-6 also antagonized estradiol (10(-9) M) stimulated growth. Estradiol 31-40 interleukin 6 Homo sapiens 9-13 8453620-13 1993 These findings indicate that IL-1 and IL-6 act additively to inhibit growth in the absence or presence of estradiol and modulate the estrogen receptor and progesterone receptor content of these cells. Estradiol 106-115 interleukin 6 Homo sapiens 38-42 8509668-6 1993 Amniotic fluid concentrations of TNF-alpha, IL-1 beta and IL-6 in cases of term elective C/S were 22.8 +/- 19.2 pg/ml, 8.1 +/- 5.2 pg/ml and 166.8 +/- 126.1 pg/ml, respectively. Carbon 89-90 interleukin 6 Homo sapiens 58-62 8482564-0 1993 Growth inhibition of ovarian cancer cells induced by antisense IL-6 oligonucleotides. Oligonucleotides 68-84 interleukin 6 Homo sapiens 63-67 7685839-7 1993 We have experienced two further patients with PMFH, in whom serum levels of IL-6 and G-CSF were markedly elevated. pmfh 46-50 interleukin 6 Homo sapiens 76-80 8508557-0 1993 Effect of gonadal steroids on the production of IL-1 and IL-6 by blood mononuclear cells in vitro. Steroids 18-26 interleukin 6 Homo sapiens 57-61 8506265-4 1993 In addition, we explored the relative role of the disulfide bridges within the IL-6 portion of DAB389-IL-6 in the stabilization of structure required for receptor-binding. Disulfides 50-59 interleukin 6 Homo sapiens 102-106 7681633-9 1993 These cAMP-induced alterations in IL-6 production were associated with corresponding alterations in IL-6 mRNA accumulation. Cyclic AMP 6-10 interleukin 6 Homo sapiens 34-38 7681633-9 1993 These cAMP-induced alterations in IL-6 production were associated with corresponding alterations in IL-6 mRNA accumulation. Cyclic AMP 6-10 interleukin 6 Homo sapiens 100-104 7681633-11 1993 Agents that increase the levels of intracellular cAMP inhibit rIL-1-induced IL-6 by human lung fibroblasts. Cyclic AMP 49-53 interleukin 6 Homo sapiens 76-80 8482564-3 1993 Inhibition of IL-6 gene expression by exposure to IL-6 antisense oligonucleotides resulted in greatly decreased cellular proliferation. Oligonucleotides 65-81 interleukin 6 Homo sapiens 14-18 8482564-3 1993 Inhibition of IL-6 gene expression by exposure to IL-6 antisense oligonucleotides resulted in greatly decreased cellular proliferation. Oligonucleotides 65-81 interleukin 6 Homo sapiens 50-54 7681633-1 1993 We characterized the effects of agents that alter intracellular adenosine 3",5"-cyclic monophosphate (cAMP) on the interleukin (IL)-6 production of human lung fibroblasts. Cyclic AMP 64-100 interleukin 6 Homo sapiens 115-133 7681633-1 1993 We characterized the effects of agents that alter intracellular adenosine 3",5"-cyclic monophosphate (cAMP) on the interleukin (IL)-6 production of human lung fibroblasts. Cyclic AMP 102-106 interleukin 6 Homo sapiens 115-133 8508557-2 1993 We investigated the effect of gonadal steroids on the production of interleukin-1 (IL-1) and IL-6, cytokines believed to be important in the pathogenesis of RA. Steroids 38-46 interleukin 6 Homo sapiens 93-97 8508557-4 1993 In studies of cells from normal male donors, 17-beta-estradiol at pharmacological concentrations (> or = 10(-6) M) enhanced IL-1 and IL-6 secretion as well as the production of cell-associated IL-1. Estradiol 45-62 interleukin 6 Homo sapiens 136-140 8508557-8 1993 It is suggested that 17-beta-estradiol may promote IL-1 and IL-6 production and release, while gestation hormone, progesterone, and testosterone may inhibit IL-1 release in vivo. Estradiol 21-38 interleukin 6 Homo sapiens 60-64 8440709-7 1993 Exposure of HepG2 cells to phorbol 12-myristate 13-acetate (PMA) or PMA-dexamethasone led to an increase in the 80-kDa IL-6 receptor mRNA and functional receptor protein. Tetradecanoylphorbol Acetate 27-58 interleukin 6 Homo sapiens 119-123 8156173-2 1993 Exposure to beta-naphthoflavone and benz(a)anthracene resulted in a higher copy number of IL-1 alpha and IL-6 mRNA while lower level of IL-1 beta mRNA was detected in these cells. benz(a)anthracene 36-53 interleukin 6 Homo sapiens 105-109 8436594-16 1993 To assess the possible role of this endogenous IL-6 in melanoma cell growth, antisense oligonucleotides to the IL-6 gene were added to cultures of melanoma cells. Oligonucleotides 87-103 interleukin 6 Homo sapiens 111-115 8440709-7 1993 Exposure of HepG2 cells to phorbol 12-myristate 13-acetate (PMA) or PMA-dexamethasone led to an increase in the 80-kDa IL-6 receptor mRNA and functional receptor protein. Tetradecanoylphorbol Acetate 60-63 interleukin 6 Homo sapiens 119-123 8440709-8 1993 Whereas treatment of HepG2 cells with PMA led to an increase in the formation of gp80.gp130.IL-6 complexes determined by cross-linking, no corresponding increase in high affinity binding sites was found. Tetradecanoylphorbol Acetate 38-41 interleukin 6 Homo sapiens 92-96 8440709-10 1993 Evidence is presented that the 80-kDa IL-6 receptor up-regulation by PMA-dexamethasone is caused by the depletion of protein kinase C since the protein kinase C inhibitor staurosporine mimics the effect of PMA-dexamethasone. Tetradecanoylphorbol Acetate 69-72 interleukin 6 Homo sapiens 38-42 8440709-10 1993 Evidence is presented that the 80-kDa IL-6 receptor up-regulation by PMA-dexamethasone is caused by the depletion of protein kinase C since the protein kinase C inhibitor staurosporine mimics the effect of PMA-dexamethasone. Dexamethasone 73-86 interleukin 6 Homo sapiens 38-42 8428540-0 1993 Increased TNF-alpha and IL6 mRNA expression by alveolar macrophages in chronic beryllium disease. Beryllium 79-88 interleukin 6 Homo sapiens 24-27 8431115-4 1993 Steroids greatly reduced the clinical response to endotoxin and attenuated the appearance of tumor necrosis factor, IL-6, and IL-8 in the circulation. Steroids 0-8 interleukin 6 Homo sapiens 116-120 7679006-3 1993 However, in the presence of optimal concentrations of granulocyte colony-stimulating factor (G-CSF) or interleukin-6 (IL-6), TPA or bryostatin markedly elevated the number of colonies formed from the GM-CFC. Tetradecanoylphorbol Acetate 125-128 interleukin 6 Homo sapiens 118-122 8428354-3 1993 In this report, we demonstrate that neutralizing antibodies to human IL-6 lower the blood calcium in nude mice carrying a human tumor associated with increased IL-6 production. Calcium 90-97 interleukin 6 Homo sapiens 69-73 8428354-5 1993 These results suggest that increased production of IL-6 may contribute to disturbances in calcium homeostasis in some malignancies, and suggest that neutralization of IL-6 effects can lower the serum calcium in these tumors. Calcium 90-97 interleukin 6 Homo sapiens 51-55 8428354-5 1993 These results suggest that increased production of IL-6 may contribute to disturbances in calcium homeostasis in some malignancies, and suggest that neutralization of IL-6 effects can lower the serum calcium in these tumors. Calcium 200-207 interleukin 6 Homo sapiens 167-171 8473012-0 1993 Interleukin-6 biosynthesis is increased by histamine in human B-cell and glioblastoma cell lines. Histamine 43-52 interleukin 6 Homo sapiens 0-13 8440336-1 1993 The exposure of human peripheral blood mononuclear cells to extremely low frequency pulsed electromagnetic fields (PEMFs) increased both the spontaneous and the PHA- and TPA-induced production of interleukin-1 (IL-1) and IL-6. Tetradecanoylphorbol Acetate 170-173 interleukin 6 Homo sapiens 221-225 8473012-1 1993 An enhancing effect of histamine on the biosynthesis and gene expression of interleukin-6 (IL-6) by human cell lines, Epstein-Barr virus (EBV)-infected human B lymphoma line BMNH and the glioblastoma line SK-MG4 has been found. Histamine 23-32 interleukin 6 Homo sapiens 76-89 8473012-3 1993 Histamine stimulates the IgM production of BMNH cells by autocrine action of IL-6 induced by histamine, since either neutralization of IL-6 by polyclonal antibody or blocking the IL-6 receptor by specific monoclonal antibody abolished the effect of histamine. Histamine 249-258 interleukin 6 Homo sapiens 77-81 8473012-1 1993 An enhancing effect of histamine on the biosynthesis and gene expression of interleukin-6 (IL-6) by human cell lines, Epstein-Barr virus (EBV)-infected human B lymphoma line BMNH and the glioblastoma line SK-MG4 has been found. Histamine 23-32 interleukin 6 Homo sapiens 91-95 8473012-3 1993 Histamine stimulates the IgM production of BMNH cells by autocrine action of IL-6 induced by histamine, since either neutralization of IL-6 by polyclonal antibody or blocking the IL-6 receptor by specific monoclonal antibody abolished the effect of histamine. Histamine 0-9 interleukin 6 Homo sapiens 77-81 8473012-3 1993 Histamine stimulates the IgM production of BMNH cells by autocrine action of IL-6 induced by histamine, since either neutralization of IL-6 by polyclonal antibody or blocking the IL-6 receptor by specific monoclonal antibody abolished the effect of histamine. Histamine 0-9 interleukin 6 Homo sapiens 135-139 8473012-3 1993 Histamine stimulates the IgM production of BMNH cells by autocrine action of IL-6 induced by histamine, since either neutralization of IL-6 by polyclonal antibody or blocking the IL-6 receptor by specific monoclonal antibody abolished the effect of histamine. Histamine 0-9 interleukin 6 Homo sapiens 135-139 8473012-3 1993 Histamine stimulates the IgM production of BMNH cells by autocrine action of IL-6 induced by histamine, since either neutralization of IL-6 by polyclonal antibody or blocking the IL-6 receptor by specific monoclonal antibody abolished the effect of histamine. Histamine 93-102 interleukin 6 Homo sapiens 77-81 8473012-3 1993 Histamine stimulates the IgM production of BMNH cells by autocrine action of IL-6 induced by histamine, since either neutralization of IL-6 by polyclonal antibody or blocking the IL-6 receptor by specific monoclonal antibody abolished the effect of histamine. Histamine 93-102 interleukin 6 Homo sapiens 135-139 8473012-3 1993 Histamine stimulates the IgM production of BMNH cells by autocrine action of IL-6 induced by histamine, since either neutralization of IL-6 by polyclonal antibody or blocking the IL-6 receptor by specific monoclonal antibody abolished the effect of histamine. Histamine 93-102 interleukin 6 Homo sapiens 135-139 8457524-1 1993 In the present study the effect of replacement of dietary fat by palm oil in the normal Western diet on the in vitro release of the inflammatory cytokines tumour necrosis factor (TNF), interleukin (IL)-6 and IL-8 was examined. Palm Oil 65-73 interleukin 6 Homo sapiens 185-203 8429822-8 1993 DEX was also found to be a potent inhibitor of IL-1-induced expression of the IL-6 gene in connective tissue-type cells from the synovium of patients with rheumatoid arthritis. Dexamethasone 0-3 interleukin 6 Homo sapiens 78-82 8421678-2 1993 It is reported here that IL-6 reduced by 5- to 20-fold the tyrosine phosphorylation of cellular proteins in these cells. Tyrosine 59-67 interleukin 6 Homo sapiens 25-29 7803192-1 1993 Supernatants derived from CD8+ lymphocytes treated with mycobacterial components, or the partially purified carbohydrates from these supernatants, increased the production of IL-4 and IL-6 by mononuclear cells. Carbohydrates 108-121 interleukin 6 Homo sapiens 184-188 7803192-2 1993 The addition of anti-IL4 or anti-IL6 antibodies to LPS stimulated MN cells incubated with supernatants from CD8+ lymphocytes or carbohydrates resulted in the restoration of other cytokine production by these MN cells. Carbohydrates 128-141 interleukin 6 Homo sapiens 33-36 8433563-4 1993 After 24-hour HPMC IL-6 release (mean +/- SEM, N = 13) (expressed as pg/micrograms cell protein) was 1.67 +/- 0.33. hydroxypropylmethylcellulose-lactose matrix 14-18 interleukin 6 Homo sapiens 19-23 7679950-5 1993 The level of IL-6 activity in the CF and RF consistently increased; beginning 2 h after TNF alpha injection and reaching the maximum between 8 h and 12 h. It returned to the basal level within 48 h. IL-1 beta was detected in the CF of three patients, its level peaking at 8 h. Prostaglandin E2 also increased after injection of TNF alpha, peaking between 4 h and 12 h and then gradually decreasing. Dinoprostone 277-293 interleukin 6 Homo sapiens 13-17 8433563-9 1993 The level of released HPMC IL-6 measured by immunometric assay (ELISA) correlated directly with that detected in the 7TD1 IL-6 bioassay (r = 0.63; P < 0.001). hydroxypropylmethylcellulose-lactose matrix 22-26 interleukin 6 Homo sapiens 27-31 8433563-9 1993 The level of released HPMC IL-6 measured by immunometric assay (ELISA) correlated directly with that detected in the 7TD1 IL-6 bioassay (r = 0.63; P < 0.001). hydroxypropylmethylcellulose-lactose matrix 22-26 interleukin 6 Homo sapiens 122-126 8433563-10 1993 Western blot analysis of concentrated HPMC supernatants using specific anti-IL-6 antibody demonstrated immunoreactive bands at 23 and 28 Kd following IL-1 beta or TNF alpha treatment. hydroxypropylmethylcellulose-lactose matrix 38-42 interleukin 6 Homo sapiens 76-80 7683137-5 1993 Furthermore, the studied cephalosporins decreased the release of IL-6 and TNF. Cephalosporins 25-39 interleukin 6 Homo sapiens 65-77 8289985-4 1993 Calcitriol therapy resulted in significant increases in the phorbol myristate acetate (PMA)-induced secretion of IL-1 and IL-6 (p = 0.04 and 0.03, respectively). Tetradecanoylphorbol Acetate 60-85 interleukin 6 Homo sapiens 122-126 8289985-4 1993 Calcitriol therapy resulted in significant increases in the phorbol myristate acetate (PMA)-induced secretion of IL-1 and IL-6 (p = 0.04 and 0.03, respectively). Tetradecanoylphorbol Acetate 87-90 interleukin 6 Homo sapiens 122-126 8434535-3 1993 Hydrocortisone reduced the production of the LPS-stimulated IL-6 to a half level. Hydrocortisone 0-14 interleukin 6 Homo sapiens 60-64 1332971-1 1992 Transcription of interleukin-6 (IL-6) gene in human HepG2 and HeLa cells was induced by treatment with interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-alpha), phorbol 12-myristate 13-acetate, or dibutyryl cyclic AMP. Tetradecanoylphorbol Acetate 166-197 interleukin 6 Homo sapiens 17-30 1332971-1 1992 Transcription of interleukin-6 (IL-6) gene in human HepG2 and HeLa cells was induced by treatment with interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-alpha), phorbol 12-myristate 13-acetate, or dibutyryl cyclic AMP. Tetradecanoylphorbol Acetate 166-197 interleukin 6 Homo sapiens 32-36 1292471-6 1992 Results from protein tyrosine phosphorylation and immediate response gene expression suggest that there are convergent and divergent points along the signal transduction pathways utilized by IL-6 or IL-11. Tyrosine 21-29 interleukin 6 Homo sapiens 191-195 1450209-4 1992 In HSF labeled with [3H]cholesterol exposure to 50 mU/ml of sphingomyelinase for 60 min resulted in an increase in labeled cholesteryl ester (CE) at 6 and 24 h of postincubation. Tritium 21-23 interleukin 6 Homo sapiens 3-6 1450209-4 1992 In HSF labeled with [3H]cholesterol exposure to 50 mU/ml of sphingomyelinase for 60 min resulted in an increase in labeled cholesteryl ester (CE) at 6 and 24 h of postincubation. Cholesterol 24-35 interleukin 6 Homo sapiens 3-6 1288731-8 1992 ), a peak of IL-6 production was reached 2 h after injection of ET-18-OCH3 [> 1280 U/ml (n = 4, p < 0.001) versus 3.5 +/- 0.2 U/ml (n = 7)], whereas BN 52211 induced a maximum of IL-6 production after 4 h (77 +/- 27 U/ml, n = 5, p < 0.001). edelfosine 64-74 interleukin 6 Homo sapiens 13-17 1288731-8 1992 ), a peak of IL-6 production was reached 2 h after injection of ET-18-OCH3 [> 1280 U/ml (n = 4, p < 0.001) versus 3.5 +/- 0.2 U/ml (n = 7)], whereas BN 52211 induced a maximum of IL-6 production after 4 h (77 +/- 27 U/ml, n = 5, p < 0.001). edelfosine 64-74 interleukin 6 Homo sapiens 185-189 1336765-4 1992 These results suggest that IL-1 beta possibly exerts one of its biological effects (IL-6 synthesis) by means of the cyclic AMP pathway. Cyclic AMP 116-126 interleukin 6 Homo sapiens 84-88 1472299-3 1992 EtOH has been implicated in the onset of a variety of immune defects in vivo including effects on the production of cytokines critically involved in inflammatory responses (tumor necrosis factor, interleukin 1 and interleukin 6). Ethanol 0-4 interleukin 6 Homo sapiens 173-228 1493924-4 1992 Further, 1,25(OH)2D3 inhibited the release of IL-6 in cultures of PHA-activated PBMC, whereas it stimulated IL-6 with the addition of PMA in these cultures. Tetradecanoylphorbol Acetate 134-137 interleukin 6 Homo sapiens 108-112 1446688-3 1992 To obtain homogeneous IL-6, Pro at -1 was exchanged for Ala by site-directed mutagenesis. Alanine 56-59 interleukin 6 Homo sapiens 22-26 1446688-7 1992 Only a portion of recombinant human IL-6 is N-glycosylated. Nitrogen 44-45 interleukin 6 Homo sapiens 36-40 1328391-8 1992 In addition, the IgE/anti-IgE-induced IL-6 production was potentiated in the presence of cAMP inducer such as the beta 2-adrenoceptor agonist salbutamol. Cyclic AMP 89-93 interleukin 6 Homo sapiens 38-42 1485590-3 1992 There was a dose-dependent decrease in the number of colonies formed in vitro of NC65 renal cell carcinoma cell line in the presence of dexamethasone which is known to inhibit the induction of IL-6 messenger RNA. Dexamethasone 136-149 interleukin 6 Homo sapiens 193-197 1485590-4 1992 IL-6 receptor antisense oligonucleotide and anti-IL-6 receptor antibody also showed growth inhibition of NC65 cells. Oligonucleotides 24-39 interleukin 6 Homo sapiens 0-4 1485590-5 1992 IL-6 antisense oligonucleotide and anti-IL-6 antibody did not alter the proliferation of NC65 cells. Oligonucleotides 15-30 interleukin 6 Homo sapiens 0-4 1330331-2 1992 Eriochrome Blue SE was employed to visualize the subcellular distribution of Mg2+ following co-incubation of Human Foreskin Fibroblasts (HSF) with Mg2+ alone or with the Mg2+/poly r(A-U) combination. magnesium ion 77-81 interleukin 6 Homo sapiens 137-140 1431212-0 1992 Cytokine-stimulated human dermal microvascular endothelial cells produce interleukin 6--inhibition by hydrocortisone, dexamethasone, and calcitriol. Hydrocortisone 102-116 interleukin 6 Homo sapiens 73-86 1431212-0 1992 Cytokine-stimulated human dermal microvascular endothelial cells produce interleukin 6--inhibition by hydrocortisone, dexamethasone, and calcitriol. Dexamethasone 118-131 interleukin 6 Homo sapiens 73-86 1431212-5 1992 The effects of hydrocortisone, dexamethasone, calcitriol, acitretin, and cyclosporin A on TNF- or IL-1 beta-induced IL-6 production by HDMEC were determined by ELISA. Acitretin 58-67 interleukin 6 Homo sapiens 116-120 1431212-5 1992 The effects of hydrocortisone, dexamethasone, calcitriol, acitretin, and cyclosporin A on TNF- or IL-1 beta-induced IL-6 production by HDMEC were determined by ELISA. Cyclosporine 73-86 interleukin 6 Homo sapiens 116-120 1431212-6 1992 Both hydrocortisone and dexamethasone dose-dependently inhibited the cytokine-induced IL-6 production, whereas the inhibition by calcitriol was less pronounced. Hydrocortisone 5-19 interleukin 6 Homo sapiens 86-90 1431212-6 1992 Both hydrocortisone and dexamethasone dose-dependently inhibited the cytokine-induced IL-6 production, whereas the inhibition by calcitriol was less pronounced. Dexamethasone 24-37 interleukin 6 Homo sapiens 86-90 1384466-10 1992 Expression of IL-6 receptor mRNA was not up-regulated by cytokines, but only by 1 microM-dexamethasone. Dexamethasone 89-102 interleukin 6 Homo sapiens 14-18 1477074-4 1992 The increase in CEA expression as a result of IL-6 treatment was also observed using SDS-PAGE/Western blot analyses, and subsequent Northern blot analyses revealed concomitant increases in CEA-related mRNA transcripts. Sodium Dodecyl Sulfate 85-88 interleukin 6 Homo sapiens 46-50 1328386-9 1992 Addition of anti-sense oligonucleotides directed to the mRNA of IL-1 alpha, IL-6, and TNF-alpha, respectively, resulted in growth arrest and cell death. Oligonucleotides 23-39 interleukin 6 Homo sapiens 76-80 1382703-8 1992 Cyclosporine A decreased cell multiplication in M1 cells without inducing apoptosis, and G-CSF and IL-6 inhibited the cytostatic effect of cyclosporine A. Cyclosporine 139-153 interleukin 6 Homo sapiens 99-103 1330331-3 1992 Phase contrast micrographs of these Mg(2+)-treated HSF cells as well as phase contrast and fluorescence micrographs of EB-treated or EB/poly r(A-U)-treated HSF cells illustrated that the Mg2+ (or EB)/poly r(A-U) combinations display altered subcellular distribution with the Mg2+ and EB being localized in the nucleoli and chromatin of the HSF cells. magnesium ion 36-42 interleukin 6 Homo sapiens 51-54 1330331-3 1992 Phase contrast micrographs of these Mg(2+)-treated HSF cells as well as phase contrast and fluorescence micrographs of EB-treated or EB/poly r(A-U)-treated HSF cells illustrated that the Mg2+ (or EB)/poly r(A-U) combinations display altered subcellular distribution with the Mg2+ and EB being localized in the nucleoli and chromatin of the HSF cells. magnesium ion 187-191 interleukin 6 Homo sapiens 156-159 1330331-3 1992 Phase contrast micrographs of these Mg(2+)-treated HSF cells as well as phase contrast and fluorescence micrographs of EB-treated or EB/poly r(A-U)-treated HSF cells illustrated that the Mg2+ (or EB)/poly r(A-U) combinations display altered subcellular distribution with the Mg2+ and EB being localized in the nucleoli and chromatin of the HSF cells. magnesium ion 187-191 interleukin 6 Homo sapiens 156-159 1439148-5 1992 When gingival mononuclear cells (GMC) isolated from AP patients were cultured without any stimulus, GMC spontaneously produced biologically active IL6 which induced peripheral blood mononuclear cells (PBMC) from the same patients to become IgG- and IgA-producing cells. Puromycin aminonucleoside 33-36 interleukin 6 Homo sapiens 147-150 1526345-6 1992 Other cytokines including IL-1, IL-6, and alpha-interferon increase hepatic de novo fatty acid synthesis. Fatty Acids 84-94 interleukin 6 Homo sapiens 32-36 1328443-3 1992 Substitution of serine for cysteine was associated with a reduction in the effectiveness of interleukin-6 in both fibrinogen secretion assays. Serine 16-22 interleukin 6 Homo sapiens 92-105 1328443-3 1992 Substitution of serine for cysteine was associated with a reduction in the effectiveness of interleukin-6 in both fibrinogen secretion assays. Cysteine 27-35 interleukin 6 Homo sapiens 92-105 1394624-2 1992 The induction of this new DNA binding activity of HSF is also obtained in a cell-free system (in vitro activation) by hyperthermia or at physiological temperature by calcium ions, low pH, urea, or non-ionic detergent. Calcium 166-173 interleukin 6 Homo sapiens 50-53 1394624-2 1992 The induction of this new DNA binding activity of HSF is also obtained in a cell-free system (in vitro activation) by hyperthermia or at physiological temperature by calcium ions, low pH, urea, or non-ionic detergent. Urea 188-192 interleukin 6 Homo sapiens 50-53 1456174-9 1992 Superoxide dismutase and glutathione peroxidase prevented H/R-induced IL-1 and IL-6 increase. r 60-61 interleukin 6 Homo sapiens 79-83 1456174-10 1992 These results constitute the first demonstration that H/R stimulates HUVEC to promote IL-1 and IL-6 production and strongly suggest a role for oxygen-derived free radicals in the cytokine synthesis. r 56-57 interleukin 6 Homo sapiens 95-99 1417523-5 1992 In situ hybridization, using a synthetic oligonucleotide DNA probe of the IL-6 gene, revealed that most PDL cells expressed IL-6 mRNA in response to IL-1 beta treatment. Oligonucleotides 41-56 interleukin 6 Homo sapiens 74-78 1505644-6 1992 Poly(A)+ RNA isolated by oligo(dT)-cellulose column chromatography was sufficient to reverse transcribe both antigen-specific T-cell-receptor beta-chain mRNA and interleukin 6 (IL-6) mRNA and subsequently amplify the cDNA with Taq polymerase in reverse transcription-polymerase chain reactions (RT-PCR). Poly A 0-7 interleukin 6 Homo sapiens 162-175 1505644-6 1992 Poly(A)+ RNA isolated by oligo(dT)-cellulose column chromatography was sufficient to reverse transcribe both antigen-specific T-cell-receptor beta-chain mRNA and interleukin 6 (IL-6) mRNA and subsequently amplify the cDNA with Taq polymerase in reverse transcription-polymerase chain reactions (RT-PCR). Poly A 0-7 interleukin 6 Homo sapiens 177-181 1623564-4 1992 At concentrations of greater than or equal to 10 nM, CRF and two analogous peptides (Tyr-CRF and alpha-helical CRF) elicited 16- to 21-fold stimulation of IL-6 production by MNC. Tyrosine 85-88 interleukin 6 Homo sapiens 155-159 1322806-6 1992 Recombinant human interleukin-6 (IL-6) caused a concentration-dependent (6-200 ng/ml) potentiation of IL-1-stimulated neutral proteinase and PGE2 production by BNC. Dinoprostone 141-145 interleukin 6 Homo sapiens 18-31 1322806-6 1992 Recombinant human interleukin-6 (IL-6) caused a concentration-dependent (6-200 ng/ml) potentiation of IL-1-stimulated neutral proteinase and PGE2 production by BNC. Dinoprostone 141-145 interleukin 6 Homo sapiens 33-37 1321338-6 1992 Treatment with quercetin inhibited the binding of HSF to the HSE in whole-cell extracts activated in vivo by heat shock and in cytoplasmic extracts activated in vitro by elevated temperature or by urea. Urea 197-201 interleukin 6 Homo sapiens 50-53 1640734-0 1992 Effect of combined treatment with interleukin-3 and interleukin-6 on 4-hydroperoxycyclophosphamide-mediated reduction of glutathione levels and cytotoxicity in normal and leukemic bone marrow progenitor cells. perfosfamide 69-98 interleukin 6 Homo sapiens 52-65 1640734-0 1992 Effect of combined treatment with interleukin-3 and interleukin-6 on 4-hydroperoxycyclophosphamide-mediated reduction of glutathione levels and cytotoxicity in normal and leukemic bone marrow progenitor cells. Glutathione 121-132 interleukin 6 Homo sapiens 52-65 1422223-2 1992 The first group contains four full-length IL-6 molecules that differ in the presence of cysteine residues involved in disulfide bridges. Cysteine 88-96 interleukin 6 Homo sapiens 42-46 1640734-8 1992 But treatment with IL-3 plus IL-6 in conjunction with 4-HC resulted in significantly higher GSH levels in NBMMC. Glutathione 92-95 interleukin 6 Homo sapiens 29-33 1640734-9 1992 These differences in intracellular GSH levels and GST activity may offer an explanation for the differential protective effects of IL-3 plus IL-6 treatment against the cytotoxic effects of 4-HC on CFU-GEMM colony growth. Glutathione 35-38 interleukin 6 Homo sapiens 141-145 1640734-9 1992 These differences in intracellular GSH levels and GST activity may offer an explanation for the differential protective effects of IL-3 plus IL-6 treatment against the cytotoxic effects of 4-HC on CFU-GEMM colony growth. perfosfamide 189-193 interleukin 6 Homo sapiens 141-145 1422223-2 1992 The first group contains four full-length IL-6 molecules that differ in the presence of cysteine residues involved in disulfide bridges. Disulfides 118-127 interleukin 6 Homo sapiens 42-46 1422223-6 1992 We have also found that the production of IL-6 containing the four cysteine residues is lower than the production of the mutant molecules that lack one or both pairs of cysteines. Cysteine 67-75 interleukin 6 Homo sapiens 42-46 1422223-6 1992 We have also found that the production of IL-6 containing the four cysteine residues is lower than the production of the mutant molecules that lack one or both pairs of cysteines. Cysteine 169-178 interleukin 6 Homo sapiens 42-46 1422223-7 1992 The yield of soluble and properly refolded IL-6 was the highest when the disulfide bond between the cysteines at positions 74 and 84 was present in the mutein form, which also lacked the 22 N-terminal amino acids. Disulfides 73-82 interleukin 6 Homo sapiens 43-47 1422223-7 1992 The yield of soluble and properly refolded IL-6 was the highest when the disulfide bond between the cysteines at positions 74 and 84 was present in the mutein form, which also lacked the 22 N-terminal amino acids. Cysteine 100-109 interleukin 6 Homo sapiens 43-47 1496542-6 1992 The overall effect of the three pharmacological agents on mitogen-up-regulated IL-6 binding was minimal; most significant were a down-regulation by all three agents of IL-6 binding by small lymphocytes in PHA/PMA cultures, a down-regulation of IL-6 binding by CsA in PHA/PMA-induced large PBMC, and an up-regulation by verapamil of PMA-induced IL-6 binding in large PBMC. Tetradecanoylphorbol Acetate 209-212 interleukin 6 Homo sapiens 168-172 1321738-0 1992 Soluble human interleukin-6-receptor modulates interleukin-6-dependent N-glycosylation of alpha 1-protease inhibitor secreted by HepG2 cells. Nitrogen 71-72 interleukin 6 Homo sapiens 14-27 1496542-6 1992 The overall effect of the three pharmacological agents on mitogen-up-regulated IL-6 binding was minimal; most significant were a down-regulation by all three agents of IL-6 binding by small lymphocytes in PHA/PMA cultures, a down-regulation of IL-6 binding by CsA in PHA/PMA-induced large PBMC, and an up-regulation by verapamil of PMA-induced IL-6 binding in large PBMC. Tetradecanoylphorbol Acetate 209-212 interleukin 6 Homo sapiens 168-172 1496542-6 1992 The overall effect of the three pharmacological agents on mitogen-up-regulated IL-6 binding was minimal; most significant were a down-regulation by all three agents of IL-6 binding by small lymphocytes in PHA/PMA cultures, a down-regulation of IL-6 binding by CsA in PHA/PMA-induced large PBMC, and an up-regulation by verapamil of PMA-induced IL-6 binding in large PBMC. Tetradecanoylphorbol Acetate 209-212 interleukin 6 Homo sapiens 168-172 1496542-3 1992 PHA alone or in combination with PMA was the most effective stimulant in up-regulating IL-6 binding in all the experiments performed. Tetradecanoylphorbol Acetate 33-36 interleukin 6 Homo sapiens 87-91 1321818-4 1992 Several single amino acid substitutions in the COOH terminus of IL-6 were found to decrease biological activity significantly. Carbonic Acid 47-51 interleukin 6 Homo sapiens 64-68 1321818-10 1992 Furthermore, the region between residues Ser178 and Arg183 (Ser-Leu-Arg-Ala-X-Arg) is identified as a receptor binding site in the COOH terminus of human IL-6. Ser-Leu-Arg 60-71 interleukin 6 Homo sapiens 154-158 1321738-1 1992 Interleukin-6 (IL-6) induces changes in gene expression and the N-glycosylation pattern of acute-phase proteins in hepatocytes. Nitrogen 64-65 interleukin 6 Homo sapiens 0-13 1321738-1 1992 Interleukin-6 (IL-6) induces changes in gene expression and the N-glycosylation pattern of acute-phase proteins in hepatocytes. Nitrogen 64-65 interleukin 6 Homo sapiens 15-19 1321738-3 1992 A genetically engineered gp80-derived soluble human IL-6-receptor (shIL-6-R) significantly enhanced the IL-6 effect on N-glycosylation changes (revealed by reactivity with the lectin-concanavalin A) of a1-protease inhibitor (PI) secreted by human hepatoma cells (HepG2). Nitrogen 119-120 interleukin 6 Homo sapiens 52-56 1321738-3 1992 A genetically engineered gp80-derived soluble human IL-6-receptor (shIL-6-R) significantly enhanced the IL-6 effect on N-glycosylation changes (revealed by reactivity with the lectin-concanavalin A) of a1-protease inhibitor (PI) secreted by human hepatoma cells (HepG2). Nitrogen 119-120 interleukin 6 Homo sapiens 69-73 1610348-3 1992 It has been shown earlier that the IL-6 polypeptide follows the classical secretory pathway where N-linked glycosylation is detectable within the first 15 minutes of labeling with [35S]-methionine and O-linked glycosylation occurs between 15-30 minutes after the start of polypeptide synthesis. Nitrogen 98-99 interleukin 6 Homo sapiens 35-39 1628823-5 1992 Addition of ATP and other hydrolyzable nucleotides results in the dissociation of hsp70 from HSF while nonhydrolyzable nucleotide analogs do not disrupt the complex. Adenosine Triphosphate 12-15 interleukin 6 Homo sapiens 93-96 1628823-7 1992 We also show that hsp70 blocks the in vitro activation of HSF from its cryptic non-DNA-binding state to a DNA-binding form; this inhibitory effect of hsp70 is abolished by ATP. Adenosine Triphosphate 172-175 interleukin 6 Homo sapiens 58-61 1627798-7 1992 In suspension cultures, reduced oxygen increased cumulative total cell production by 125% and 167%, and cumulative progenitor production by 68% and 21%, with IL-1/IL-3 and IL-3/IL-6, respectively. Oxygen 32-38 interleukin 6 Homo sapiens 172-181 1627798-14 1992 Endogenous production of IL-6 was significantly higher under 5% O2 in both suspension and stromal cultures, and IL-6 production was increased threefold by the addition of IL-1/IL-3. Oxygen 64-66 interleukin 6 Homo sapiens 25-29 1280631-1 1992 The current study was designed to observe the effects of drugs used for the treatment of inflammatory diseases (glucocorticoid, aspirin, and gamma globulin) on interleukin 6 (IL-6) production in the liver which may be involved in acute phase protein stimulation. Aspirin 128-135 interleukin 6 Homo sapiens 175-179 1280631-6 1992 At 48 h after addition of glucocorticoid and aspirin, there was a suppression of IL-6 activity in the culture supernatants, which was associated with a decrease of mRNA level in the cells. Aspirin 45-52 interleukin 6 Homo sapiens 81-85 1280631-8 1992 These data demonstrate that glucocorticoid and aspirin are potent regulators of IL-6 synthesis in the hepatoma cell. Aspirin 47-54 interleukin 6 Homo sapiens 80-84 1596568-2 1992 Exposure to IL-3, IL-7, IL-1, and IL-6 resulted in a mean 2.8-, 1.5-, 1.4-, and 1.6-fold stimulation of 3H-thymidine (3H-TdR) incorporation, respectively. Tritium 104-106 interleukin 6 Homo sapiens 34-38 1610348-3 1992 It has been shown earlier that the IL-6 polypeptide follows the classical secretory pathway where N-linked glycosylation is detectable within the first 15 minutes of labeling with [35S]-methionine and O-linked glycosylation occurs between 15-30 minutes after the start of polypeptide synthesis. Sulfur-35 181-184 interleukin 6 Homo sapiens 35-39 1610348-3 1992 It has been shown earlier that the IL-6 polypeptide follows the classical secretory pathway where N-linked glycosylation is detectable within the first 15 minutes of labeling with [35S]-methionine and O-linked glycosylation occurs between 15-30 minutes after the start of polypeptide synthesis. Methionine 186-196 interleukin 6 Homo sapiens 35-39 1610348-4 1992 Pulse-chase experiments using [32P]-orthophosphate or [35S]-methionine as tracers indicated that phosphorylation of IL-6 occurred prior to its O-glycosylation suggesting that the de novo synthesized IL-6 polypeptide is rapidly, perhaps even cotranslationally, phosphorylated at an intravesicular site (in the endoplasmic reticulum and/or Golgi). Phosphates 36-50 interleukin 6 Homo sapiens 116-120 1610348-4 1992 Pulse-chase experiments using [32P]-orthophosphate or [35S]-methionine as tracers indicated that phosphorylation of IL-6 occurred prior to its O-glycosylation suggesting that the de novo synthesized IL-6 polypeptide is rapidly, perhaps even cotranslationally, phosphorylated at an intravesicular site (in the endoplasmic reticulum and/or Golgi). Sulfur-35 55-58 interleukin 6 Homo sapiens 116-120 1610348-4 1992 Pulse-chase experiments using [32P]-orthophosphate or [35S]-methionine as tracers indicated that phosphorylation of IL-6 occurred prior to its O-glycosylation suggesting that the de novo synthesized IL-6 polypeptide is rapidly, perhaps even cotranslationally, phosphorylated at an intravesicular site (in the endoplasmic reticulum and/or Golgi). Methionine 60-70 interleukin 6 Homo sapiens 116-120 1604240-1 1992 Murine hepatocytes cultured in the presence of human recombinant interleukin-6 (IL-6) show increased synthesis of fibrinogen and complement component C3 by the addition of histamine. Histamine 172-181 interleukin 6 Homo sapiens 65-78 1632677-0 1992 Prostaglandin E2 production during hepatic regeneration downregulates Kupffer cell IL-6 production. Dinoprostone 0-16 interleukin 6 Homo sapiens 83-87 1632677-6 1992 Production of IL-6 by regenerating liver KC was further increased (p less than 0.05) by placing these same KC in 10 microM L-arginine RPMI-1640 tissue culture media. Arginine 123-133 interleukin 6 Homo sapiens 14-18 1632677-9 1992 The authors conclude that during hepatic regeneration KC IL-6 production is elevated but controlled in an autoregulatory fashion by KC PGE2 production. Dinoprostone 135-139 interleukin 6 Homo sapiens 57-61 1317386-0 1992 Interleukin-1 (IL-1)-induced IL-6- and IL-6-receptor-mediated release of human chorionic gonadotropin by choriocarcinoma cell lines (Jar and HCCM-5) activates adenosine 3",5"-monophosphate-independent signal transduction pathway. Cyclic AMP 159-188 interleukin 6 Homo sapiens 29-33 1317386-0 1992 Interleukin-1 (IL-1)-induced IL-6- and IL-6-receptor-mediated release of human chorionic gonadotropin by choriocarcinoma cell lines (Jar and HCCM-5) activates adenosine 3",5"-monophosphate-independent signal transduction pathway. Cyclic AMP 159-188 interleukin 6 Homo sapiens 39-43 1391235-4 1992 Treatment of the two IL-6-producing melanoma cell lines with interleukin-1 beta, tumor necrosis factor-alpha, or phorbol myristate acetate caused a marked increase in IL-6 production. Tetradecanoylphorbol Acetate 113-138 interleukin 6 Homo sapiens 21-25 1391235-4 1992 Treatment of the two IL-6-producing melanoma cell lines with interleukin-1 beta, tumor necrosis factor-alpha, or phorbol myristate acetate caused a marked increase in IL-6 production. Tetradecanoylphorbol Acetate 113-138 interleukin 6 Homo sapiens 167-171 1630586-0 1992 Involvement of arachidonic acid cascade pathways in interleukin-6-stimulated corticotropin-releasing factor release in vitro. Arachidonic Acid 15-31 interleukin 6 Homo sapiens 52-65 1630586-2 1992 Since metabolites of the arachidonic acid cascade (AAC) have been implicated in mediating actions of cytokines in different tissues and some AAC inhibitors were able to block pyrogenic effects of cytokines and suppress IL-1-induced ACTH secretion, we decided to examine the mechanism of IL-6 action on CRF release in vitro. Arachidonic Acid 25-41 interleukin 6 Homo sapiens 287-291 1630586-5 1992 As reported previously, 10(-13) M IL-6 increased CRF release, which was significantly suppressed by DEX in a dose-dependent manner. Dexamethasone 100-103 interleukin 6 Homo sapiens 34-38 1630586-7 1992 The response to IL-6 was completely blocked at the highest DEX concentration evaluated (10(-5) M). Dexamethasone 59-62 interleukin 6 Homo sapiens 16-20 1376256-7 1992 Independent of cAMP, by tyrosine phosphorylation of specific substrates IL-1 also induces c-myc and IL-6 mRNA expression and cellular proliferation. Tyrosine 24-32 interleukin 6 Homo sapiens 100-104 1382623-8 1992 The increase of interleukin-6 in the group receiving steroids was less pronounced than that in the control group, indicating that corticosteroids inhibit the generation of interleukin-6 in vivo. Steroids 53-61 interleukin 6 Homo sapiens 16-29 1382623-8 1992 The increase of interleukin-6 in the group receiving steroids was less pronounced than that in the control group, indicating that corticosteroids inhibit the generation of interleukin-6 in vivo. Steroids 53-61 interleukin 6 Homo sapiens 172-185 1319454-11 1992 At concentrations as low as 30 nmol/l, PGE2 stimulated IL-6 release but the maximum stimulation obtained with PGE2 was only threefold. Dinoprostone 39-43 interleukin 6 Homo sapiens 55-59 1323058-3 1992 When evaluated in human hepatoblastoma-derived (Hep G2) cells exposed to different doses of the recombinant human cytokine for variable time intervals, IL-6 caused a dose- and time-dependent decrease in the secretion of [35S]methionine-labeled TBG, transthyretin (TTR), and albumin. Sulfur-35 221-224 interleukin 6 Homo sapiens 152-156 1323058-3 1992 When evaluated in human hepatoblastoma-derived (Hep G2) cells exposed to different doses of the recombinant human cytokine for variable time intervals, IL-6 caused a dose- and time-dependent decrease in the secretion of [35S]methionine-labeled TBG, transthyretin (TTR), and albumin. Methionine 225-235 interleukin 6 Homo sapiens 152-156 1604240-1 1992 Murine hepatocytes cultured in the presence of human recombinant interleukin-6 (IL-6) show increased synthesis of fibrinogen and complement component C3 by the addition of histamine. Histamine 172-181 interleukin 6 Homo sapiens 80-84 1516641-6 1992 Our data indicate that (a) fibroblasts secrete interleukin-6 but not interleukin-1, (b) interleukin-1 alpha, but not interleukin-6, stimulates fibroblast arachidonic acid metabolism and (c) the mechanisms involved in the metabolism of endogenous arachidonic acid are more sensitive to human recombinant interleukin-1 alpha than those involved in metabolism of the exogenous substrate. Arachidonic Acid 246-262 interleukin 6 Homo sapiens 47-60 1569208-8 1992 However, 2 x 10(-4) M rotenone induced DNA binding of HSF within 30 min, in association with a fall in ATP to 30% of control levels, and a fall in pHi from 7.3 to 6.9. Adenosine Triphosphate 103-106 interleukin 6 Homo sapiens 54-57 1569208-10 1992 Conversely, in studies that lowered ATP stores at normal pH (high K+/nigericin) we found induction of HSF-DNA binding activity. Adenosine Triphosphate 36-39 interleukin 6 Homo sapiens 102-105 1569208-11 1992 Our data indicate that the effects of ATP depletion alone are sufficient to induce the DNA binding of HSF when oxidative metabolism is impaired, and are consistent with a model proposed recently for transcriptional regulation of stress protein genes during ischemia. Adenosine Triphosphate 38-41 interleukin 6 Homo sapiens 102-105 1554202-5 1992 Uncorrected and urea-corrected IL-6 concentrations were also higher in the two groups (18.5 and 30.8 versus 5.0 fmol/ml BALF, p less than 0.01; 157.7 and 444 versus 88.5 fmol/ml ELF, p less than 0.05). Urea 16-20 interleukin 6 Homo sapiens 31-35 1318656-7 1992 To evaluate a possible direct effect on the pituitary, IL-6 was incubated in vitro with hemipituitaries under an atmosphere of 95% O2/5% CO2. Oxygen 131-133 interleukin 6 Homo sapiens 55-59 1314274-7 1992 Using the RIA, IL-6 produced in culture by human monocytes in response to various stimuli (LPS, IL-1, dibutyryl cAMP) was measured. Cyclic AMP 112-116 interleukin 6 Homo sapiens 15-19 1503609-1 1992 Cyclosporin A (CsA) is a potent inhibitor of cytokine (IL-2-IL-6, IFN gamma) production by CD4+ T lymphocytes stimulated via the T cell antigen receptor pathway. Cyclosporine 0-13 interleukin 6 Homo sapiens 60-64 1499642-5 1992 Metabolic labelling with [35S]-methionine followed by immunoprecipitation of IL-6 showed that the increased IL-6 activity in the medium of hrC5a treated monocytes was due to a stimulation of the de novo synthesis of IL-6. Sulfur-35 26-29 interleukin 6 Homo sapiens 108-112 1499642-5 1992 Metabolic labelling with [35S]-methionine followed by immunoprecipitation of IL-6 showed that the increased IL-6 activity in the medium of hrC5a treated monocytes was due to a stimulation of the de novo synthesis of IL-6. Sulfur-35 26-29 interleukin 6 Homo sapiens 108-112 1499642-5 1992 Metabolic labelling with [35S]-methionine followed by immunoprecipitation of IL-6 showed that the increased IL-6 activity in the medium of hrC5a treated monocytes was due to a stimulation of the de novo synthesis of IL-6. Methionine 31-41 interleukin 6 Homo sapiens 108-112 1499642-5 1992 Metabolic labelling with [35S]-methionine followed by immunoprecipitation of IL-6 showed that the increased IL-6 activity in the medium of hrC5a treated monocytes was due to a stimulation of the de novo synthesis of IL-6. Methionine 31-41 interleukin 6 Homo sapiens 108-112 1618596-7 1992 NF-IL6 is also involved in the transcriptional regulation of various acute phase protein genes IL-6-triggered association of IL-6R and gp130 on hepatocytes, through intermediate steps including serine-phosphorylation of pre-existing NF-IL6 protein, leads to binding of NF-IL6 to IL-6-responsive elements and activation of acute-phase protein genes. Serine 194-200 interleukin 6 Homo sapiens 95-99 1618596-7 1992 NF-IL6 is also involved in the transcriptional regulation of various acute phase protein genes IL-6-triggered association of IL-6R and gp130 on hepatocytes, through intermediate steps including serine-phosphorylation of pre-existing NF-IL6 protein, leads to binding of NF-IL6 to IL-6-responsive elements and activation of acute-phase protein genes. Serine 194-200 interleukin 6 Homo sapiens 125-129 1558971-1 1992 IL-6-PE4E is a recombinant protein consisting of interleukin-6 (IL-6) fused to a mutant form of Pseudomonas exotoxin in which four basic amino acids are changed to glutamate (PE4E). Amino Acids, Basic 131-148 interleukin 6 Homo sapiens 0-4 1558971-1 1992 IL-6-PE4E is a recombinant protein consisting of interleukin-6 (IL-6) fused to a mutant form of Pseudomonas exotoxin in which four basic amino acids are changed to glutamate (PE4E). Glutamic Acid 164-173 interleukin 6 Homo sapiens 0-4 1503609-1 1992 Cyclosporin A (CsA) is a potent inhibitor of cytokine (IL-2-IL-6, IFN gamma) production by CD4+ T lymphocytes stimulated via the T cell antigen receptor pathway. Cyclosporine 15-18 interleukin 6 Homo sapiens 60-64 1545152-4 1992 After 24 h of exposure to PMA, levels for most cytokines declined to baseline, except for IL-6 which appeared as a new transcript. Tetradecanoylphorbol Acetate 26-29 interleukin 6 Homo sapiens 90-94 1546713-14 1992 S-IL-6 levels correlated with bone-marrow plasmacytosis (P less than .0005), serum-lactate dehydrogenase (S-LDH; P less than .005), serum beta 2 microglobulin (S -beta 2m; P less than .01), and serum calcium (S-Ca; P less than .025) and inversely correlated with haemoglobin (P less than .025). Calcium 200-207 interleukin 6 Homo sapiens 2-6 1547819-5 1992 IL-1 beta and IL-6 were elevated in many patients before PEG IL-2 administration, forming a continuous, log-normal distribution among patients. Polyethylene Glycols 57-60 interleukin 6 Homo sapiens 14-18 1547819-11 1992 After the fourth administration of PEG IL-2, the peak level of IFN-gamma was 2 to 20 times higher than after the first, while the peak level of IL-6 did not change in a consistent direction. Polyethylene Glycols 35-38 interleukin 6 Homo sapiens 144-148 1318290-6 1992 The addition of BK to HSF caused a time and concentration dependent increase in PGE2 production. Dinoprostone 80-84 interleukin 6 Homo sapiens 22-25 1545152-5 1992 PMA-stimulated CMK lines synthesized low levels of TNF-alpha and IL-6, and higher levels of GM-CSF, IL-1 beta, and IL-1 alpha protein. Tetradecanoylphorbol Acetate 0-3 interleukin 6 Homo sapiens 65-69 1537389-3 1992 The effect appeared within 30 min and returned to basal levels after 2 h. The addition of antisense oligonucleotides to c-fos significantly inhibited IL 6-induced IgM production by SKW 6.4 cells (p less than 0.001), whereas control oligonucleotides had no inhibitory effect. Oligonucleotides 100-116 interleukin 6 Homo sapiens 150-154 1544406-0 1992 Up-regulation of the interleukin-6-signal transducing protein (gp130) by interleukin-6 and dexamethasone in HepG2 cells. Dexamethasone 91-104 interleukin 6 Homo sapiens 21-34 1536986-2 1992 We have investigated the effects of oestradiol on the release of two cytokines, IL-6 and TNF, known to be produced by normal human osteoblast-like cells. Estradiol 36-46 interleukin 6 Homo sapiens 80-92 1536986-3 1992 The effect of oestradiol on basal and stimulated IL-6 and TNF release was investigated. Estradiol 14-24 interleukin 6 Homo sapiens 49-53 1536986-9 1992 rhIL-1 alpha (10 U/ml) was a consistent and potent stimulator of IL-6 and TNF release, and the glucocorticoid hydrocortisone was found to be a powerful suppressor of both IL-6 and TNF release under basal or stimulatory conditions. Hydrocortisone 110-124 interleukin 6 Homo sapiens 171-175 1550404-10 1992 In contrast, dexamethasone (10(-6) mol/l) suppressed the ability of IL-1 to increase the expression of IL-6 mRNA. Dexamethasone 13-26 interleukin 6 Homo sapiens 103-107 1537389-3 1992 The effect appeared within 30 min and returned to basal levels after 2 h. The addition of antisense oligonucleotides to c-fos significantly inhibited IL 6-induced IgM production by SKW 6.4 cells (p less than 0.001), whereas control oligonucleotides had no inhibitory effect. Oligonucleotides 232-248 interleukin 6 Homo sapiens 150-154 1425019-6 1992 High IL-6 production could be induced by stimulating the cells with a combination of phorbol-12-myristate 13-acetate (PMA) and anti-CD28 antibodies. Tetradecanoylphorbol Acetate 85-116 interleukin 6 Homo sapiens 5-9 1370390-7 1992 Hybridization with 32P-labeled oligonucleotides specific for the respective cytokine messenger RNAs (mRNAs) showed a 10-fold lower prevalence of transcripts for TNF, IL-1, and IL-6, as well. Oligonucleotides 31-47 interleukin 6 Homo sapiens 176-180 1336653-0 1992 Interleukin 6 production by mononuclear phagocytes can be stimulated by leukotrienes. Leukotrienes 72-84 interleukin 6 Homo sapiens 0-13 1336653-7 1992 These data suggest that leukotrienes may modulate the production of IL6 and indicate some underlying mechanisms which may be involved. Leukotrienes 24-36 interleukin 6 Homo sapiens 68-71 1537055-2 1992 The addition of non-cytotoxic concentrations of Adriamycin (doxorubicin), vincristine and 4-OOH-cyclophosphamide (the in vitro active analogue of cyclophosphamide) resulted in suppression of IL-6 release. perfosfamide 90-112 interleukin 6 Homo sapiens 191-195 1385054-1 1992 The interleukin 6 (IL-6) promoter is rapidly and transiently activated by other cytokines, including IL-1 and tumour necrosis factor (TNF), as well as by phorbol esters and cyclic AMP agonists. Cyclic AMP 173-183 interleukin 6 Homo sapiens 4-17 1385054-1 1992 The interleukin 6 (IL-6) promoter is rapidly and transiently activated by other cytokines, including IL-1 and tumour necrosis factor (TNF), as well as by phorbol esters and cyclic AMP agonists. Cyclic AMP 173-183 interleukin 6 Homo sapiens 19-23 19912845-4 1992 During short-term incubations of U87MG cells (6 h) in the presence of IL 1beta and dexamethasone (DEX), DEX inhibited IL 1beta-stimulated IL 6 production over the entire range of the dose-response curve. Dexamethasone 83-96 interleukin 6 Homo sapiens 138-142 19912845-4 1992 During short-term incubations of U87MG cells (6 h) in the presence of IL 1beta and dexamethasone (DEX), DEX inhibited IL 1beta-stimulated IL 6 production over the entire range of the dose-response curve. Dexamethasone 98-101 interleukin 6 Homo sapiens 138-142 19912845-4 1992 During short-term incubations of U87MG cells (6 h) in the presence of IL 1beta and dexamethasone (DEX), DEX inhibited IL 1beta-stimulated IL 6 production over the entire range of the dose-response curve. Dexamethasone 104-107 interleukin 6 Homo sapiens 138-142 19912845-5 1992 However, when cells were preincubated in the presence of DEX for 15 h and then challenged with IL 1beta or IL 1beta and DEX, there was a left-shift in the IL 1,B dose-response curve, suggesting an increased sensitivity of the cells to respond to IL 1 and produce IL 6. Dexamethasone 57-60 interleukin 6 Homo sapiens 263-267 19912845-5 1992 However, when cells were preincubated in the presence of DEX for 15 h and then challenged with IL 1beta or IL 1beta and DEX, there was a left-shift in the IL 1,B dose-response curve, suggesting an increased sensitivity of the cells to respond to IL 1 and produce IL 6. Dexamethasone 120-123 interleukin 6 Homo sapiens 263-267 19912845-6 1992 In fact, the ED(50) for IL 1beta-stimulated IL 6 production was about 1.3 pM in cells not preincubated with DEX, but was reduced to 0.25 pM in cells that were preincubated with DEX. Dexamethasone 108-111 interleukin 6 Homo sapiens 44-48 19912845-6 1992 In fact, the ED(50) for IL 1beta-stimulated IL 6 production was about 1.3 pM in cells not preincubated with DEX, but was reduced to 0.25 pM in cells that were preincubated with DEX. Dexamethasone 177-180 interleukin 6 Homo sapiens 44-48 19912845-7 1992 However, maximum IL 6 production at high doses of IL 1beta was inhibited in cells cultured in the presence of DEX during the IL 1 challenge. Dexamethasone 110-113 interleukin 6 Homo sapiens 17-21 1281599-4 1992 The percentage of cIg-positive plasmacytoid cells after 10 days of culture was significantly higher in the presence of both IL-3 and IL-6 than with each interleukin alone or the control medium. 2-AMINO-6-CHLOROPYRAZINE 18-21 interleukin 6 Homo sapiens 133-137 1281599-6 1992 These findings suggest that myeloma precursor cells exist in the peripheral blood of MM patients, especially at diagnosis, and differentiate into cIg-positive cells in the presence of IL-3 and IL-6. 2-AMINO-6-CHLOROPYRAZINE 146-149 interleukin 6 Homo sapiens 193-197 1294020-6 1992 IL-6 transcripts were nearly undetectable by blotting in keratinocytes grown in low-calcium serum-free medium, but low levels could be induced by treatment with 1.8 mM CaCl2. Calcium 84-91 interleukin 6 Homo sapiens 0-4 1370208-4 1992 Dexamethasone (1 mumol/L) concordantly repressed expression of GM-CSF, NAP-1/IL-8 and IL-6. Dexamethasone 0-13 interleukin 6 Homo sapiens 86-90 1370208-9 1992 Further experiments showed that dexamethasone downregulates expression of GM-CSF, NAP-1/IL-8, and IL-6 mainly by decreasing the mRNA stability of these cytokines, and that the dexamethasone-mediated repression of cytokine expression depends on ongoing protein and RNA syntheses. Dexamethasone 32-45 interleukin 6 Homo sapiens 98-102 1370208-9 1992 Further experiments showed that dexamethasone downregulates expression of GM-CSF, NAP-1/IL-8, and IL-6 mainly by decreasing the mRNA stability of these cytokines, and that the dexamethasone-mediated repression of cytokine expression depends on ongoing protein and RNA syntheses. Dexamethasone 176-189 interleukin 6 Homo sapiens 98-102 1425019-6 1992 High IL-6 production could be induced by stimulating the cells with a combination of phorbol-12-myristate 13-acetate (PMA) and anti-CD28 antibodies. Tetradecanoylphorbol Acetate 118-121 interleukin 6 Homo sapiens 5-9 1384862-0 1992 The effects of FK-506 and cyclosporin A on the proliferation of PHA-stimulated T cells in response to IL-2, IL-4 or IL-6. Cyclosporine 26-39 interleukin 6 Homo sapiens 116-120 1294622-4 1992 Among the beta-lactams the most active were the cephalosporins (cephalexin, cefamandol, ceftazidin, and a sulbactam-ampicillin combination) in inducing the release of TNF, IL-1 alpha, and IL-6 from monocytes, and releasing IL-4 and IFN-tau from lymphocytes. Cephalosporins 48-62 interleukin 6 Homo sapiens 188-192 1577093-3 1992 IL-6 was measured by a [3H] thymidine incorporation assay using the IL-6-dependent B9 cell line; 1 U is approximately equal to 1 pg/ml of a recombinant (r)IL-6 standard. Tritium 24-26 interleukin 6 Homo sapiens 0-4 1384862-4 1992 However, the response of the PHA-pulsed T cells to IL-6 was still inhibited by FK-506 or Cs A, but the inhibitory effect gradually decreased as the time in which the PHA-pulsed T cells interacted with IL-6 was prolonged. Cyclosporine 89-93 interleukin 6 Homo sapiens 51-55 1384862-7 1992 It is likely that the two drugs inhibit the expression of lymphokine receptors, by interfering Ca(2+)-related signals and that IL-6 induces T cell proliferation in a different way than IL-2 and IL-4, which are FK-506- and Cs A-sensitive. Cyclosporine 222-226 interleukin 6 Homo sapiens 127-131 18475434-0 1992 Effect of hydrocortisone on interleukin-6 production in human ,peripheral blood rnononuclear ceils. Hydrocortisone 10-24 interleukin 6 Homo sapiens 28-41 1556702-6 1992 The rate of the correlation between synovial IL-6 level and concentration of serum C-reactive protein in RA was inversely proportional to the dose of steroid treatment in patients with RA. Steroids 150-157 interleukin 6 Homo sapiens 45-49 18475434-1 1992 The effect of hydrocortisone on the production of interleukin-6 (IL-6) in human peripheral blood mononuclear cells was studied. Hydrocortisone 14-28 interleukin 6 Homo sapiens 50-63 18475434-1 1992 The effect of hydrocortisone on the production of interleukin-6 (IL-6) in human peripheral blood mononuclear cells was studied. Hydrocortisone 14-28 interleukin 6 Homo sapiens 65-69 18475434-5 1992 Hydrocortisone (10(-10) M to 10(-3) M) inhibited LPS-stimulated IL-6 production in a dose-dependent manner. Hydrocortisone 0-14 interleukin 6 Homo sapiens 64-68 1797449-0 1991 Recombinant human interleukin-6 enhances the antiproliferation and differentiation inducing effects of retinoic acid in HL-60 human myeloid leukaemic cells. Tretinoin 103-116 interleukin 6 Homo sapiens 18-31 1962626-4 1991 IL-6 levels in B-CPH and PBC were similar to those of controls. benzo(c)phenanthrene 15-20 interleukin 6 Homo sapiens 0-4 1662392-7 1991 Loss of signal-transducing ability of gp130 with such a mutation coincided with disappearance of IL-6-induced tyrosine phosphorylation of gp130. Tyrosine 110-118 interleukin 6 Homo sapiens 97-101 1744107-0 1991 Role of disulfide bonds in biologic activity of human interleukin-6. Disulfides 8-17 interleukin 6 Homo sapiens 54-67 1744107-1 1991 We have examined the functional importance of the two disulfide bonds formed by the four conserved cysteines of human interleukin (IL-6). Disulfides 54-63 interleukin 6 Homo sapiens 118-135 1744107-1 1991 We have examined the functional importance of the two disulfide bonds formed by the four conserved cysteines of human interleukin (IL-6). Cysteine 99-108 interleukin 6 Homo sapiens 118-135 1744107-2 1991 Using a bacterial expression system, we have synthesized a series of recombinant IL-6 mutants in which the constituent cysteines of the first (Cys45-Cys51), second (Cys74-Cys84), or both disulfide bonds of recombinant human interleukin-6 were replaced by other amino acids. Cysteine 119-128 interleukin 6 Homo sapiens 81-85 1744107-2 1991 Using a bacterial expression system, we have synthesized a series of recombinant IL-6 mutants in which the constituent cysteines of the first (Cys45-Cys51), second (Cys74-Cys84), or both disulfide bonds of recombinant human interleukin-6 were replaced by other amino acids. Disulfides 187-196 interleukin 6 Homo sapiens 81-85 1744107-5 1991 These results indicate that the first disulfide bond of human interleukin-6 is not required for maintenance of normal biologic activity. Disulfides 38-47 interleukin 6 Homo sapiens 62-75 1797449-6 1991 The addition of interleukin-6 to all-trans retinoic acid-treated cultures of HL-60 human myeloid leukaemia cells significantly enhanced the desired antiproliferation effect of all-trans retinoic acid. Tretinoin 43-56 interleukin 6 Homo sapiens 16-29 1797449-6 1991 The addition of interleukin-6 to all-trans retinoic acid-treated cultures of HL-60 human myeloid leukaemia cells significantly enhanced the desired antiproliferation effect of all-trans retinoic acid. Tretinoin 186-199 interleukin 6 Homo sapiens 16-29 1797449-8 1991 The combination of interleukin-6 with all-trans retinoic acid reduced the doses of all-trans retinoic acid required to induce the same differentiation of HL-60 cells as single agent by between 1.7- and 4.8-fold; that is, the efficacy of all-trans retinoic acid in inducing the differentiation of human myeloid leukaemia HL-60 cells was increased up to 4.8 times by its combination with interleukin-6. Tretinoin 48-61 interleukin 6 Homo sapiens 386-399 1797449-8 1991 The combination of interleukin-6 with all-trans retinoic acid reduced the doses of all-trans retinoic acid required to induce the same differentiation of HL-60 cells as single agent by between 1.7- and 4.8-fold; that is, the efficacy of all-trans retinoic acid in inducing the differentiation of human myeloid leukaemia HL-60 cells was increased up to 4.8 times by its combination with interleukin-6. Tretinoin 93-106 interleukin 6 Homo sapiens 19-32 1797449-8 1991 The combination of interleukin-6 with all-trans retinoic acid reduced the doses of all-trans retinoic acid required to induce the same differentiation of HL-60 cells as single agent by between 1.7- and 4.8-fold; that is, the efficacy of all-trans retinoic acid in inducing the differentiation of human myeloid leukaemia HL-60 cells was increased up to 4.8 times by its combination with interleukin-6. Tretinoin 93-106 interleukin 6 Homo sapiens 386-399 1797449-8 1991 The combination of interleukin-6 with all-trans retinoic acid reduced the doses of all-trans retinoic acid required to induce the same differentiation of HL-60 cells as single agent by between 1.7- and 4.8-fold; that is, the efficacy of all-trans retinoic acid in inducing the differentiation of human myeloid leukaemia HL-60 cells was increased up to 4.8 times by its combination with interleukin-6. Tretinoin 93-106 interleukin 6 Homo sapiens 19-32 1797449-8 1991 The combination of interleukin-6 with all-trans retinoic acid reduced the doses of all-trans retinoic acid required to induce the same differentiation of HL-60 cells as single agent by between 1.7- and 4.8-fold; that is, the efficacy of all-trans retinoic acid in inducing the differentiation of human myeloid leukaemia HL-60 cells was increased up to 4.8 times by its combination with interleukin-6. Tretinoin 93-106 interleukin 6 Homo sapiens 386-399 1779468-4 1991 On the contrary, IL-6 mRNA was detected by the method of RT-PCR, and its expression induced by the addition of 12-O-tetradecanoylphorbol-13-acetate (TPA) could be clearly shown by Northern blotting. Tetradecanoylphorbol Acetate 111-147 interleukin 6 Homo sapiens 17-21 1779468-4 1991 On the contrary, IL-6 mRNA was detected by the method of RT-PCR, and its expression induced by the addition of 12-O-tetradecanoylphorbol-13-acetate (TPA) could be clearly shown by Northern blotting. Tetradecanoylphorbol Acetate 149-152 interleukin 6 Homo sapiens 17-21 1937963-3 1991 Treatment of ACHN cells with rh IFN-gamma also leads to inhibition of proliferation of these cells in a dose-dependent manner, that can be reversed by exogenous rh IL-6, while IFN-alpha, IL-2, IL-4 and vinblastine or 17-beta-estradiol has no effect on growth (3H-thymidine uptake) of ACHN cells and IL-6 expression. Estradiol 217-234 interleukin 6 Homo sapiens 164-168 1931077-7 1991 Monolayers exposed to histamine for 30 min released interleukin-6 and fibronectin in the apical direction, in a dose-dependent manner. Histamine 22-31 interleukin 6 Homo sapiens 52-65 1667244-3 1991 Its secretion is stimulated by interleukin 6 (IL-6) in a dose-dependent fashion and can further be positively modulated by dexamethasone. Dexamethasone 123-136 interleukin 6 Homo sapiens 46-50 1667244-5 1991 Incubation of HepG2 cells simultaneously with IL-6 and dexamethasone increases the magnitude of CRP release significantly above that seen with IL-6 alone. Dexamethasone 55-68 interleukin 6 Homo sapiens 143-147 1667244-6 1991 After preincubation with dexamethasone, the kinetics of CRP release, induced by IL-6, are increased and approach that observed in the case of alpha 1-acid glycoprotein (alpha 1-AGP) without dexamethasone pretreatment. Dexamethasone 25-38 interleukin 6 Homo sapiens 80-84 1368110-0 1991 In-vivo processing of the initiator methionine from recombinant methionyl human interleukin-6 synthesized in Escherichia coli overproducing aminopeptidase-P. Methionine 36-46 interleukin 6 Homo sapiens 80-93 1368110-1 1991 Human interleukin 6 (hIL-6) overproduced in Escherichia coli HB101 was found to partially retain the initiator methionine (Met) residue (Met-hIL-6). Methionine 111-121 interleukin 6 Homo sapiens 21-26 1773338-0 1991 Interleukin-6 as an endogenous pyrogen: induction of prostaglandin E2 in brain but not in peripheral blood mononuclear cells. Dinoprostone 53-69 interleukin 6 Homo sapiens 0-13 1368110-1 1991 Human interleukin 6 (hIL-6) overproduced in Escherichia coli HB101 was found to partially retain the initiator methionine (Met) residue (Met-hIL-6). Methionine 111-121 interleukin 6 Homo sapiens 141-146 1913843-9 1991 In situ hybridization analysis of cytocentrifuged TEC with an mRNA antisense probe specific for human IL-6 and labeled with 35S demonstrated that up to 90% of TEC could be induced to express the IL-6 gene. Sulfur-35 124-127 interleukin 6 Homo sapiens 195-199 1724187-4 1991 The results also show a complex interaction between insulin, interleukin 6, and glucocorticoids because insulin is able to inhibit the dexamethasone induction of alpha 1-antichymotrypsin, and in the presence of interleukin 6, dexamethasone is able to regulate the production of fibrinogen and prealbumin. Dexamethasone 135-148 interleukin 6 Homo sapiens 61-74 1724187-4 1991 The results also show a complex interaction between insulin, interleukin 6, and glucocorticoids because insulin is able to inhibit the dexamethasone induction of alpha 1-antichymotrypsin, and in the presence of interleukin 6, dexamethasone is able to regulate the production of fibrinogen and prealbumin. Dexamethasone 226-239 interleukin 6 Homo sapiens 61-74 1940549-4 1991 IL-6, TGF-beta 1 and decidual supernatants stimulated both hPL, hCG production and 3H-thymidine uptake, especially TGF-beta 1 and decidual supernatants. Tritium 83-85 interleukin 6 Homo sapiens 0-4 1773338-3 1991 In the present study, we examined whether interleukin-6 (IL-6) stimulates PGE2 formation in a manner similar to IL-1 and TNF. Dinoprostone 74-78 interleukin 6 Homo sapiens 42-55 1773338-3 1991 In the present study, we examined whether interleukin-6 (IL-6) stimulates PGE2 formation in a manner similar to IL-1 and TNF. Dinoprostone 74-78 interleukin 6 Homo sapiens 57-61 1773338-6 1991 IL-6 fever was blocked by prior administration of the cyclooxygenase inhibitor ibuprofen. Ibuprofen 79-88 interleukin 6 Homo sapiens 0-4 1912582-5 1991 The proliferative response of each line to recombinant IL-6 was measured in a clonogenic assay providing human plasma and methylcellulose as a viscous support and by 3H-thymidine uptake in liquid suspension culture. Tritium 166-168 interleukin 6 Homo sapiens 55-59 1655384-1 1991 Interleukin 6 (IL-6) production was shown to be stimulated by vasoactive intestinal peptide via cAMP dependent signal transduction pathway in the pituitary. Cyclic AMP 96-100 interleukin 6 Homo sapiens 0-13 1777846-2 1991 injection of human recombinant interleukin-6 (IL-6; 20-100 ng) caused significant increases in colonic temperature and resting oxygen consumption (VO2) in conscious rats. Oxygen 127-133 interleukin 6 Homo sapiens 31-44 1777846-2 1991 injection of human recombinant interleukin-6 (IL-6; 20-100 ng) caused significant increases in colonic temperature and resting oxygen consumption (VO2) in conscious rats. Oxygen 127-133 interleukin 6 Homo sapiens 46-50 1914227-9 1991 The patients with IL-6 in the urine had a mean serum creatinine significantly higher than those without IL-6. Creatinine 53-63 interleukin 6 Homo sapiens 18-22 1655384-1 1991 Interleukin 6 (IL-6) production was shown to be stimulated by vasoactive intestinal peptide via cAMP dependent signal transduction pathway in the pituitary. Cyclic AMP 96-100 interleukin 6 Homo sapiens 15-19 1956868-3 1991 The incorporation of [14C]acetate into cholesterol in HSF was inhibited by AR 12463 and AR 12456, but not by trapidil. Cholesterol 39-50 interleukin 6 Homo sapiens 54-57 1893946-3 1991 In contrast, recombinant human interleukin 6 (rhIL-6) did not stimulate [3H]thymidine uptake but did increase [3H]leucine incorporation into purified rat megakaryocytes. Tritium 111-113 interleukin 6 Homo sapiens 31-44 1930911-4 1991 IL-1, IL-6 and TNF-alpha have several functions which suggest that they participate in the chronic disease process of rheumatoid arthritis, such as increasing production of eicosanoid, collagenase and prostaglandin E2. Eicosanoids 173-183 interleukin 6 Homo sapiens 6-10 1930911-4 1991 IL-1, IL-6 and TNF-alpha have several functions which suggest that they participate in the chronic disease process of rheumatoid arthritis, such as increasing production of eicosanoid, collagenase and prostaglandin E2. Dinoprostone 201-217 interleukin 6 Homo sapiens 6-10 1908551-0 1991 Leukemia inhibitory factor and interleukin-6 trigger the same immediate early response, including tyrosine phosphorylation, upon induction of myeloid leukemia differentiation. Tyrosine 98-106 interleukin 6 Homo sapiens 31-44 1908551-7 1991 Using a variety of protein kinase activators and inhibitors, we have shown that the intracellular signalling pathways for both LIF and IL-6 are distinct from those of known second messengers and involve protein phosphorylation, notably tyrosine phosphorylation of a 160-kDa protein, as an essential step(s) in the immediate early activation of MyD gene expression. Tyrosine 236-244 interleukin 6 Homo sapiens 135-139 1651357-6 1991 Similar results were obtained for the effect of dexamethasone on the induction of SAA by IL-6 plus IL-1 alpha. Dexamethasone 48-61 interleukin 6 Homo sapiens 89-93 1651357-12 1991 These data indicate that IL-6, IL-1 alpha, TNF-alpha, and dexamethasone in various combinations are all capable of influencing synthesis of SAA in Hep 3B cells, whereas only IL-6, IL-1 alpha, and dexamethasone can influence CRP synthesis. Dexamethasone 196-209 interleukin 6 Homo sapiens 25-29 1872826-0 1991 Effect of synthesized constituents in the L-tryptophan product on the differentiation of eosinophils and the induction of IL-6: a possible cause of eosinophilia-myalgia syndrome. Tryptophan 42-54 interleukin 6 Homo sapiens 122-126 1871124-1 1991 Transfection of HeLa cells with cDNA vectors expressing the wild-type human glucocorticoid receptor (GR) enabled dexamethasone to strongly repress cytokine- and second messenger-induced expression of cotransfected chimeric reporter genes containing transcription regulatory DNA elements from the human interleukin 6 (IL-6) promoter. Dexamethasone 113-126 interleukin 6 Homo sapiens 302-315 1871124-1 1991 Transfection of HeLa cells with cDNA vectors expressing the wild-type human glucocorticoid receptor (GR) enabled dexamethasone to strongly repress cytokine- and second messenger-induced expression of cotransfected chimeric reporter genes containing transcription regulatory DNA elements from the human interleukin 6 (IL-6) promoter. Dexamethasone 113-126 interleukin 6 Homo sapiens 317-321 1664173-6 1991 Conversely, the preincubation of pituitary cells with interleukin-6 for 20 min significantly reduced VIP- and forskolin-stimulated adenylate cyclase activity, as well as inositol phosphate production and free cytosolic calcium increase induced by TRH. Calcium 219-226 interleukin 6 Homo sapiens 54-67 1864979-6 1991 There was a dose-dependent decrease, however, in [3H]-thymidine uptake in the presence of IL-6 antisense (and not sense) oligodeoxynucleotides; in the presence of 20 microM IL-6 antisense, an 80 and 95% inhibition of the proliferation of U 266 and RPMI 8226 cells was observed, respectively. Tritium 50-52 interleukin 6 Homo sapiens 90-94 1864979-0 1991 Interleukin-6 antisense oligonucleotides inhibit the growth of human myeloma cell lines. Oligonucleotides 24-40 interleukin 6 Homo sapiens 0-13 1864979-6 1991 There was a dose-dependent decrease, however, in [3H]-thymidine uptake in the presence of IL-6 antisense (and not sense) oligodeoxynucleotides; in the presence of 20 microM IL-6 antisense, an 80 and 95% inhibition of the proliferation of U 266 and RPMI 8226 cells was observed, respectively. Tritium 50-52 interleukin 6 Homo sapiens 173-177 2033252-0 1991 Retinoic acid-induced growth inhibition of a human myeloma cell line via down-regulation of IL-6 receptors. Tretinoin 0-13 interleukin 6 Homo sapiens 92-96 1721559-1 1991 3H-Labelled kappa-elastin peptides (kE:75 kDa molecular weight) were shown to bind to confluent human skin fibroblast (HSF) cultures in a time-dependent and saturable manner. Tritium 0-2 interleukin 6 Homo sapiens 119-122 1721559-5 1991 This stimulatory effect of kE on the binding of iE to HSF could be inhibited by neomycin, retinal and pertussis toxin, substances which act at different levels of the transduction mechanism following the activation of the receptor and the subsequent triggering of cell biological events (chemotaxis, modification of calcium fluxes). Calcium 316-323 interleukin 6 Homo sapiens 54-57 1904540-1 1991 We investigated the recognition of the conserved 5-bp repeated motif NGAAN, which occurs in heat shock gene promoters of Drosophila melanogaster and other eukaryotic organisms, by human heat shock transcription factor (HSF). 5-bp 49-53 interleukin 6 Homo sapiens 186-217 1904540-1 1991 We investigated the recognition of the conserved 5-bp repeated motif NGAAN, which occurs in heat shock gene promoters of Drosophila melanogaster and other eukaryotic organisms, by human heat shock transcription factor (HSF). 5-bp 49-53 interleukin 6 Homo sapiens 219-222 2044224-4 1991 IL-6 levels were higher in patients who died (P = 0.04) and correlated with the features of severe disease including: increased grade of encephalopathy, increased neutrophil count, increased prothrombin ratio, hypotension, increased serum creatinine and increased serum bilirubin. Creatinine 239-249 interleukin 6 Homo sapiens 0-4 2033252-2 1991 Using AF10 cells, whose growth was determined to be mediated by the autocrine action of IL-6, we found that RA reduction of IL-6R was concentration-dependent over a range of 10(-11) to 10(-5) M and corresponded to the ability of the retinoid to inhibit cell proliferation. Tretinoin 108-110 interleukin 6 Homo sapiens 88-92 1710843-7 1991 CsA inhibited IL-6-induced IgG production by CESS cells by 64% at 100 ng/ml and 6-MP inhibited this response by 82% at 250 ng/ml. Cyclosporine 0-3 interleukin 6 Homo sapiens 14-18 1710843-11 1991 These experiments clearly demonstrate that CsA, MP and 6-MP have direct inhibitory effects on the response of human B cells to IL-6. Cyclosporine 43-46 interleukin 6 Homo sapiens 127-131 2033081-5 1991 Elution of the major 85-kDa complex and re-electrophoresis through sodium dodecyl sulfate-PAGE revealed that it represented a heteromeric aggregate of the 25- and 30-kDa IL-6 species; the 45-65-kDa complexes were largely composed of the 25-kDa protein. Sodium Dodecyl Sulfate 67-89 interleukin 6 Homo sapiens 170-174 2031150-5 1991 Cortisol and dexamethasone, but not oestrogen, progesterone, or testosterone, dramatically suppressed the LPS-stimulated secretion of IL-6 by fetal Kupffer cells. Hydrocortisone 0-8 interleukin 6 Homo sapiens 134-138 2033081-1 1991 Natural human interleukin-6 (IL-6) characterized under completely denaturing conditions consists of a set of differentially modified phosphoglycoproteins of molecular mass in the range from 23 to 30 kDa ("25-kDa" O-glycosylated species and "30-kDa" O- and N-glycosylated species). Nitrogen 0-1 interleukin 6 Homo sapiens 14-27 2033081-1 1991 Natural human interleukin-6 (IL-6) characterized under completely denaturing conditions consists of a set of differentially modified phosphoglycoproteins of molecular mass in the range from 23 to 30 kDa ("25-kDa" O-glycosylated species and "30-kDa" O- and N-glycosylated species). Nitrogen 0-1 interleukin 6 Homo sapiens 29-33 2033081-2 1991 The 25-kDa O-glycosylated IL-6 (which contains only Ser- or Thr-GalNAc-Gal-NeuNAc and thus should not bind wheat germ or lentil lectins) bound to and was eluted from a wheat germ lectin affinity column by GlcNAc and from a lentil lectin affinity column by methyl-alpha-D-Man suggesting that the 25-kDa IL-6 species formed heteromeric complexes with the N-glycosylated 30-kDa IL-6. Serine 52-55 interleukin 6 Homo sapiens 26-30 2033081-2 1991 The 25-kDa O-glycosylated IL-6 (which contains only Ser- or Thr-GalNAc-Gal-NeuNAc and thus should not bind wheat germ or lentil lectins) bound to and was eluted from a wheat germ lectin affinity column by GlcNAc and from a lentil lectin affinity column by methyl-alpha-D-Man suggesting that the 25-kDa IL-6 species formed heteromeric complexes with the N-glycosylated 30-kDa IL-6. Threonine 60-63 interleukin 6 Homo sapiens 26-30 2033081-2 1991 The 25-kDa O-glycosylated IL-6 (which contains only Ser- or Thr-GalNAc-Gal-NeuNAc and thus should not bind wheat germ or lentil lectins) bound to and was eluted from a wheat germ lectin affinity column by GlcNAc and from a lentil lectin affinity column by methyl-alpha-D-Man suggesting that the 25-kDa IL-6 species formed heteromeric complexes with the N-glycosylated 30-kDa IL-6. Nitrogen 67-68 interleukin 6 Homo sapiens 26-30 1851359-4 1991 Recombinant interleukin 6 slightly inhibited the production of cAMP, but failed to influence the production of thyroglobulin or the DNA content. Cyclic AMP 63-67 interleukin 6 Homo sapiens 12-25 1653054-6 1991 12-O-tetradecanoyl phorbol-13-acetate (TPA) but not 8-bromoadenosine 3",5"-cyclic monophosphate (Br-cAMP) induces changes in the morphology and associative behavior of ZR-75-1 cells that are similar but not identical to those caused by IL-6. Tetradecanoylphorbol Acetate 0-37 interleukin 6 Homo sapiens 236-240 1653054-6 1991 12-O-tetradecanoyl phorbol-13-acetate (TPA) but not 8-bromoadenosine 3",5"-cyclic monophosphate (Br-cAMP) induces changes in the morphology and associative behavior of ZR-75-1 cells that are similar but not identical to those caused by IL-6. Tetradecanoylphorbol Acetate 39-42 interleukin 6 Homo sapiens 236-240 2057724-2 1991 Osteoarthrosis synovial fluid was characterised by the absence of interleukin 1 beta while tumour necrosis factor alpha and interleukin 6 were present in relatively large amounts, by a very high phospholipase A2 activity contrasting with a very low concentration of prostaglandin E2, and by a collagenase/proteoglycanase activity only slightly less constant and high as in rheumatoid arthritis. Dinoprostone 266-282 interleukin 6 Homo sapiens 124-137 1680274-1 1991 Based on our earlier data on the enhancing effect of histamine on the action of interleukin-6 (IL-6), we have studied the molecular mechanisms of these interactions. Histamine 53-62 interleukin 6 Homo sapiens 80-93 1680274-1 1991 Based on our earlier data on the enhancing effect of histamine on the action of interleukin-6 (IL-6), we have studied the molecular mechanisms of these interactions. Histamine 53-62 interleukin 6 Homo sapiens 95-99 1680274-2 1991 The effect of histamine was investigated on the binding of 125I-IL-6 by B lymphoma cell line CESS, monocytoid cell line U937 and hepatoma cell line HepG2. Histamine 14-23 interleukin 6 Homo sapiens 64-68 1680274-3 1991 Histamine increases the IL-6 binding by CESS cells and inhibits that by U937 and HepG2 cells. Histamine 0-9 interleukin 6 Homo sapiens 24-28 1680274-4 1991 Using H1 receptor (cetirizin and loderix) and H2 receptor (cimetidine and ranitidine) specific antagonists, an H1-dependent stimulation of IL-6 binding by CESS cells was found. Cetirizine 19-28 interleukin 6 Homo sapiens 139-143 1680274-5 1991 In contrast, down-regulation of IL-6 binding by histamine was clearly mediated through H2 receptors. Histamine 48-57 interleukin 6 Homo sapiens 32-36 1883960-4 1991 Amino acid sequencing revealed that the major amino terminus in the fibroblast-derived 23- to 25-kD O-glycosylated IL-6 was at Ala28 whereas the major amino terminus in the 28- to 30-kD N- and O-glycosylated IL-6 was at Val30, suggesting that targeting of newly synthesized IL-6 polypeptides into the two different processing pathways in fibroblasts may be keyed to differences in the signal peptide cleavage site. Nitrogen 186-187 interleukin 6 Homo sapiens 115-119 1883960-5 1991 Unexpectedly, IL-6 "constitutively" secreted by the Epstein-Barr virus (EBV)-infected human and primate (tamarin) B-cell lines designated sfBJAB and sfBT, respectively, consisted of a major apparently unglycosylated 21-kD species and a minor 25-kD N-glycosylated species. Nitrogen 248-249 interleukin 6 Homo sapiens 14-18 2031150-5 1991 Cortisol and dexamethasone, but not oestrogen, progesterone, or testosterone, dramatically suppressed the LPS-stimulated secretion of IL-6 by fetal Kupffer cells. Dexamethasone 13-26 interleukin 6 Homo sapiens 134-138 1714773-3 1991 Antiserum to human IL-6 abolishes induced protein synthesis and amino acid uptake elicited by hrIL-6 but has no effect on the acute-phase response of rat liver cells stimulated by LIF. hril-6 94-100 interleukin 6 Homo sapiens 19-23 2007597-10 1991 These results suggest that IL-6 affects calcium mobilization in gonadotropes indirectly via paracrine pathways. Calcium 40-47 interleukin 6 Homo sapiens 27-31 1649133-6 1991 IL-6, unlike IL-1 beta, significantly suppressed the production of NAG and superoxide by synovial cells and chondrocytes. Superoxides 75-85 interleukin 6 Homo sapiens 0-4 2007786-6 1991 Addition of hydrocortisone, prednisolone, or dexamethasone immediately after UVB irradiation significantly blocked UVB or IL-1-induced IL-6 mRNA expression and production by EC. Hydrocortisone 12-26 interleukin 6 Homo sapiens 135-139 2007786-6 1991 Addition of hydrocortisone, prednisolone, or dexamethasone immediately after UVB irradiation significantly blocked UVB or IL-1-induced IL-6 mRNA expression and production by EC. Dexamethasone 45-58 interleukin 6 Homo sapiens 135-139 2007597-2 1991 The intracellular free calcium concentration ([Ca2+]i) in single gonadotropes was measured with a calcium-sensitive fluorescent dye indo-1 or fura-2 and a digital imaging fluorescence microscopic system to determine how interleukin-6 (IL-6) increases release of gonadotropins. Calcium 23-30 interleukin 6 Homo sapiens 220-233 2045425-2 1991 Experiments with an adenocarcinoma-derived cell line (HeLa) reveal that activation of the transfected human IL-6 promoter occurs largely through two partially overlapping second messenger (cAMP, phorbol ester)- and cytokine (IL-1, TNF, serum)-responsive enhancer elements (MRE 1, -173 to -151 and MRE II, -158 to -145). Cyclic AMP 189-193 interleukin 6 Homo sapiens 108-112 2045425-4 1991 The mechanism of dexamethasone-mediated repression of IL-6 gene expression in epithelial cells involves occlusion of the entire MRE enhancer region and of the core-promoter elements (TATA-box and RNA start site) by ligand-activated glucocorticoid receptor. Dexamethasone 17-30 interleukin 6 Homo sapiens 54-58 2005380-7 1991 Higher levels of IL-6 were produced spontaneously by GMC when compared with Con A-stimulated PBMC. Puromycin aminonucleoside 53-56 interleukin 6 Homo sapiens 17-21 1901038-0 1991 Chemical modification and 1H-NMR studies on the receptor-binding region of human interleukin 6. Hydrogen 26-28 interleukin 6 Homo sapiens 81-94 1901038-4 1991 The hydroxynitrobenzyl chromophore attached to Trp158 in the IL-6 molecule showed a different absorption spectrum when the labeled IL-6 was bound to the soluble IL-6 receptor. hydroxynitrobenzyl 4-22 interleukin 6 Homo sapiens 61-65 1901038-4 1991 The hydroxynitrobenzyl chromophore attached to Trp158 in the IL-6 molecule showed a different absorption spectrum when the labeled IL-6 was bound to the soluble IL-6 receptor. hydroxynitrobenzyl 4-22 interleukin 6 Homo sapiens 131-135 1901038-4 1991 The hydroxynitrobenzyl chromophore attached to Trp158 in the IL-6 molecule showed a different absorption spectrum when the labeled IL-6 was bound to the soluble IL-6 receptor. hydroxynitrobenzyl 4-22 interleukin 6 Homo sapiens 131-135 2005380-9 1991 The induction of SFC by GMC supernatants was inhibited by incubation with a goat anti-human IL-6 antibody. Puromycin aminonucleoside 24-27 interleukin 6 Homo sapiens 92-96 1995637-8 1991 Intracellular limited proteolysis of IL-6 could be demonstrated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Sodium Dodecyl Sulfate 67-89 interleukin 6 Homo sapiens 37-41 1997647-5 1991 Synovial cell synthesis of bFGF, TGF beta 1, GM-CSF, IL-1 beta, and IL-6 was confirmed by 35S-methionine labeling and immunoprecipitation. Sulfur-35 90-93 interleukin 6 Homo sapiens 68-72 1991169-6 1991 Furthermore, the addition of IL-6 antisense oligonucleotides also inhibits U266 proliferation. Oligonucleotides 44-60 interleukin 6 Homo sapiens 29-33 1989345-0 1991 The in vivo effect of cyclosporine on interleukin-6 gene expression in renal transplant recipients. Cyclosporine 22-34 interleukin 6 Homo sapiens 38-51 1651782-5 1991 However, IL-1 alpha or beta induced PGE2 production by human dermal fibroblasts and by human synovial cells was inhibited (in 5/8 experiments) up to 62% by addition of IL-6. Dinoprostone 36-40 interleukin 6 Homo sapiens 168-172 2040361-0 1991 Interleukin-6 stimulates prostaglandin production by human amnion and decidual cells. Prostaglandins 25-38 interleukin 6 Homo sapiens 0-13 2040361-1 1991 The effects of interleukin-6 on prostaglandin production by cells from two key sources on intrauterine prostaglandin, i.e. amnion and decidua, have been evaluated. Prostaglandins 32-45 interleukin 6 Homo sapiens 15-28 2040361-2 1991 Interleukin-6 induced a concentration-related increase in prostaglandin production by amnion and decidual cells. Prostaglandins 58-71 interleukin 6 Homo sapiens 0-13 1651782-6 1991 On the contrary in 2/4 experiments TNF alpha-induced PGE2 production was increased (approximately 2 fold) by the addition of IL-6. Dinoprostone 53-57 interleukin 6 Homo sapiens 125-129 1679283-5 1991 CD8+ lymphocytes grown in the presence of PHA + IL-6 incorporate (3H)-thymidine to the same extent as those stimulated with PHA + IL-2, but do not increase in number until day 6 of culture. 3h)-thymidine 66-79 interleukin 6 Homo sapiens 48-52 1991487-0 1991 L-arginine-dependent destruction of intrahepatic malaria parasites in response to tumor necrosis factor and/or interleukin 6 stimulation. Arginine 0-10 interleukin 6 Homo sapiens 111-124 1991487-3 1991 The possible participation of an L-arginine-dependent effector mechanism has been studied to explain the TNF/IL 6-induced inhibition. Arginine 33-43 interleukin 6 Homo sapiens 109-113 1991487-4 1991 We thus investigated if NGmonomethyl-L-arginine and N omega-nitro-L-arginine, two specific inhibitors of inorganic nitrogen oxide synthesis from L-arginine, were able to affect the inhibitory effect of TNF and/or IL 6 in co-cultures. omega-N-Methylarginine 24-47 interleukin 6 Homo sapiens 213-217 1989890-5 1991 After phorbol ester myristate acetate (PMA) treatment, all the cell lines studied expressed or overexpressed IL-6. Tetradecanoylphorbol Acetate 39-42 interleukin 6 Homo sapiens 109-113 1814850-4 1991 Aspirin, ibuprofen, and phenylbutazone also inhibited IL-6 production by adherent cells stimulated with lipopolysaccharide (LPS). Aspirin 0-7 interleukin 6 Homo sapiens 54-58 1814850-4 1991 Aspirin, ibuprofen, and phenylbutazone also inhibited IL-6 production by adherent cells stimulated with lipopolysaccharide (LPS). Ibuprofen 9-18 interleukin 6 Homo sapiens 54-58 1814850-6 1991 The addition of PGE2 corresponding to the amount produced by adherent cells stimulated with LPS slightly increased IL-6 production by unstimulated adherent cells, but to a lower level than that reached with LPS. Dinoprostone 16-20 interleukin 6 Homo sapiens 115-119 1814850-7 1991 An anti-PGE2 antibody partially blocked IL-6 production by adherent cells stimulated with LPS. Dinoprostone 8-12 interleukin 6 Homo sapiens 40-44 1814850-8 1991 These results suggest that, in addition to the inhibition of PGE2 production, other mediators including cyclooxygenase products or other action mechanisms are involved in the inhibition of IL-6 production by these drugs. Dinoprostone 61-65 interleukin 6 Homo sapiens 189-193 2268669-1 1990 Partial assignments for the 1H-NMR resonances of the aromatic residues in human interleukin 6 (IL-6) are reported. Hydrogen 28-30 interleukin 6 Homo sapiens 80-93 1713637-6 1991 In contrast, IL-1 beta, TNF, and TPA equally stimulated increased levels of M-CSF, GM-CSF, IL-1 beta and IL-6 RNAs. Tetradecanoylphorbol Acetate 33-36 interleukin 6 Homo sapiens 105-109 1766257-6 1991 In the presence of IL-3 or IL-6, 3H-TdR incorporation increased in cells from 2 out of 5 patients with CD7+4-8- acute leukemia. Tritium 33-35 interleukin 6 Homo sapiens 27-31 1775266-5 1991 In comparison to polystyrole (724 +/- 34 pg/ml), IL-6 production by PBMC was significantly reduced in the presence of Cuprophan (151 +/- 45 pg/ml), Hemophan (167 +/- 6 pg/ml) and polyacrylonitrile (108 +/- 33 pg/ml). Hemophan 148-156 interleukin 6 Homo sapiens 49-53 2046859-2 1991 The glucocorticoid hormone dexamethasone (DEX) dose-dependently inhibited the release of IL-6, the IC50 being 2.43 +/- 0.93 nM. Dexamethasone 27-40 interleukin 6 Homo sapiens 89-93 2046859-2 1991 The glucocorticoid hormone dexamethasone (DEX) dose-dependently inhibited the release of IL-6, the IC50 being 2.43 +/- 0.93 nM. Dexamethasone 42-45 interleukin 6 Homo sapiens 89-93 2046859-4 1991 The adenylate cyclase activator forskolin increased IL-6 release in aggregate cultures in the presence of DEX. Dexamethasone 106-109 interleukin 6 Homo sapiens 52-56 1987687-8 1991 Contrariwise, recipients afflicted with CsA-induced nephrotoxicity displayed reduced IL-6 levels (mean = 1.4 +/- 0.18 U/ml). Cyclosporine 40-43 interleukin 6 Homo sapiens 85-89 2268669-1 1990 Partial assignments for the 1H-NMR resonances of the aromatic residues in human interleukin 6 (IL-6) are reported. Hydrogen 28-30 interleukin 6 Homo sapiens 95-99 2268669-2 1990 The homonuclear Hartmann-Hahn spectrum clearly shows all connectivities for the histidine, tyrosine and tryptophan residues that exist in IL-6. Histidine 80-89 interleukin 6 Homo sapiens 138-142 2268669-2 1990 The homonuclear Hartmann-Hahn spectrum clearly shows all connectivities for the histidine, tyrosine and tryptophan residues that exist in IL-6. Tyrosine 91-99 interleukin 6 Homo sapiens 138-142 2268669-2 1990 The homonuclear Hartmann-Hahn spectrum clearly shows all connectivities for the histidine, tyrosine and tryptophan residues that exist in IL-6. Tryptophan 104-114 interleukin 6 Homo sapiens 138-142 2124160-7 1990 What is not explicable is the normalization of the acute phase response soon after the commencement of steroid therapy when circulating levels of interleukin-6 are still high. Steroids 103-110 interleukin 6 Homo sapiens 146-159 1701344-2 1990 When cells were cultured in the presence of 12-O-tetradecanoylphorbol-13-acetate, significant amounts of IL6 were detected in the culture supernatants of Chang liver cells, HLF cells, and HLE cells. Tetradecanoylphorbol Acetate 44-80 interleukin 6 Homo sapiens 105-108 1707461-4 1990 Dexamethasone added to the cultures at 10(-7) M concentration suppressed the constitutive expression of the IL-6 gene. Dexamethasone 0-13 interleukin 6 Homo sapiens 108-112 1707461-5 1990 At a concentration of 10(-5) M, dexamethasone partially suppressed the IL-1 enhanced expression of IL-6. Dexamethasone 32-45 interleukin 6 Homo sapiens 99-103 2208809-4 1990 In addition, natural human C5ades Arg and natural porcine C5a were able to induce a similar level of IL-6. Arginine 34-37 interleukin 6 Homo sapiens 101-105 2093210-0 1990 Production of interleukin-6 from macrophages by MDP-Lys (L 18), romurtide. romurtide 64-73 interleukin 6 Homo sapiens 14-27 2093210-4 1990 We measured the IL-6 levels in the culture supernatants of peripheral blood mononuclear cells (PBMCs), adherent cells and nonadherent cells in the presence of romurtide. romurtide 159-168 interleukin 6 Homo sapiens 16-20 2093210-5 1990 Significant augmentation of IL-6 from PBMCs and adherent cells, but not nonadherent cells, was observed in the presence of romurtide in vitro. romurtide 123-132 interleukin 6 Homo sapiens 28-32 1700730-7 1990 Increase of 3H-thymidine incorporation by megakaryoblasts could be duplicated by exogenous IL-6 that could be blocked by neutralizing MoAb to IL-6. Tritium 12-14 interleukin 6 Homo sapiens 91-95 1700730-7 1990 Increase of 3H-thymidine incorporation by megakaryoblasts could be duplicated by exogenous IL-6 that could be blocked by neutralizing MoAb to IL-6. Tritium 12-14 interleukin 6 Homo sapiens 142-146 2242429-11 1990 DNA synthesis induced by TPA/Ca2+ was blocked specifically by anti-IL-6 Ab; in contrast, the HCL proliferative response to SAC, TNF, or IL-4 and IL-5 was not inhibited by anti-IL-6 Ab. Tetradecanoylphorbol Acetate 25-28 interleukin 6 Homo sapiens 67-71 2242429-13 1990 Finally, peroxidase-antiperoxidase staining demonstrated that HCLs are induced by TPA/Ca2+, but not by SAC, to produce intracytoplasmic IL-6. Tetradecanoylphorbol Acetate 82-85 interleukin 6 Homo sapiens 136-140 2174456-6 1990 Exogenous recombinant IL-6 reduced cyclic AMP production in response to TSH when added to thyroid cell cultures. Cyclic AMP 35-45 interleukin 6 Homo sapiens 22-26 1699862-7 1990 Although the synthetic glucocorticoid dexamethasone slightly modulated the effect of recombinant interleukin-6, it was not an absolute requirement for the induction of acute-phase protein synthesis in human hepatocytes. Dexamethasone 38-51 interleukin 6 Homo sapiens 97-110 2170518-9 1990 TGF-beta added along with IL-6 inhibited the metabolic labeling of CRP with [35S]methionine; however, enhanced incorporation of [35S]methionine into CRP was observed when the cells were exposed to TGF-beta before IL-6 addition. Methionine 133-143 interleukin 6 Homo sapiens 213-217 2233715-2 1990 The mechanism of the efficient repression of the IL-6 promoter by dexamethasone (Dex) was investigated in HeLa cells transiently transfected with plasmid constructs containing different IL-6 promoter elements linked to the herpesvirus thymidine kinase gene (tk) promoter and the bacterial chloramphenicol acetyltransferase gene (cat) and cotransfected with cDNA vectors constitutively expressing either the active wild-type or inactive mutant human glucocorticoid receptor (GR). Dexamethasone 66-79 interleukin 6 Homo sapiens 49-53 2233715-2 1990 The mechanism of the efficient repression of the IL-6 promoter by dexamethasone (Dex) was investigated in HeLa cells transiently transfected with plasmid constructs containing different IL-6 promoter elements linked to the herpesvirus thymidine kinase gene (tk) promoter and the bacterial chloramphenicol acetyltransferase gene (cat) and cotransfected with cDNA vectors constitutively expressing either the active wild-type or inactive mutant human glucocorticoid receptor (GR). Dexamethasone 81-84 interleukin 6 Homo sapiens 49-53 2233715-4 1990 The induction by pseudorabies virus of an IL-6 construct containing the IL-6 TATA box and the RNA start site ("initiator" or Inr element) but not the MRE region was also repressed by Dex in the presence of wild-type GR. Dexamethasone 183-186 interleukin 6 Homo sapiens 42-46 2233715-4 1990 The induction by pseudorabies virus of an IL-6 construct containing the IL-6 TATA box and the RNA start site ("initiator" or Inr element) but not the MRE region was also repressed by Dex in the presence of wild-type GR. Dexamethasone 183-186 interleukin 6 Homo sapiens 72-76 2170518-9 1990 TGF-beta added along with IL-6 inhibited the metabolic labeling of CRP with [35S]methionine; however, enhanced incorporation of [35S]methionine into CRP was observed when the cells were exposed to TGF-beta before IL-6 addition. Sulfur-35 77-80 interleukin 6 Homo sapiens 26-30 2170518-9 1990 TGF-beta added along with IL-6 inhibited the metabolic labeling of CRP with [35S]methionine; however, enhanced incorporation of [35S]methionine into CRP was observed when the cells were exposed to TGF-beta before IL-6 addition. Methionine 81-91 interleukin 6 Homo sapiens 26-30 1715769-1 1990 The cDNA for human interleukin 6 (IL 6) was stably expressed at high levels in the three mammalian cell lines COS-7, PA317, and GH3 to yield IL 6 proteins of 25 to 27, 26, 22 to 24, and 23 kDa molecular mass. 3'-dGTP 128-131 interleukin 6 Homo sapiens 19-32 2118969-9 1990 In contrast, PMA-induced IL-6 gene transcription was not affected by rIL-4. Tetradecanoylphorbol Acetate 13-16 interleukin 6 Homo sapiens 25-29 2129417-3 1990 Keratinocyte-growth was increased by stimulation with recombinant IL 6 (as measured by either [3H] thymidine uptake or direct cell count). Tritium 95-97 interleukin 6 Homo sapiens 66-70 1715769-1 1990 The cDNA for human interleukin 6 (IL 6) was stably expressed at high levels in the three mammalian cell lines COS-7, PA317, and GH3 to yield IL 6 proteins of 25 to 27, 26, 22 to 24, and 23 kDa molecular mass. 3'-dGTP 128-131 interleukin 6 Homo sapiens 34-38 1715769-7 1990 In contrast, PA317 and GH3 IL 6 were 230 and 6.7 times more effective than COS-7 IL 6 in inducing Ig production in CESS cells. 3'-dGTP 23-26 interleukin 6 Homo sapiens 27-31 1715769-8 1990 Also, PA317 and GH3 IL 6 were more effective than COS-7 IL 6 in inducing the acute-phase protein fibrinogen in human hepatocytes. 3'-dGTP 16-19 interleukin 6 Homo sapiens 20-24 2236903-2 1990 Single organic- and water-soluble metabolites increased with BaP concentration in both types of HSF, but the ratio normal/variant increased with BaP concentration. Water 20-25 interleukin 6 Homo sapiens 96-99 1696597-5 1990 The effect of IL-6 on M12/CD40+ cells not only required intact CD40 including threonine 234 but also was specific because IL-6 mAb blocked the inhibitory activity. Threonine 78-87 interleukin 6 Homo sapiens 14-18 1966584-3 1990 The de novo conversion of cultured HSF was demonstrated in a large fraction of ST:FeSV (FeLV)-transformed foci in the presence of dexamethasone (DX). Dexamethasone 130-143 interleukin 6 Homo sapiens 35-38 2165096-3 1990 IL-6-stimulated IgM production was inhibited by elevated intracellular cAMP induced either by the addition of dibutyryl cAMP or cholera toxin. Cyclic AMP 71-75 interleukin 6 Homo sapiens 0-4 2165096-3 1990 IL-6-stimulated IgM production was inhibited by elevated intracellular cAMP induced either by the addition of dibutyryl cAMP or cholera toxin. Cyclic AMP 120-124 interleukin 6 Homo sapiens 0-4 2165096-4 1990 The inhibitory effect of elevated intracellular cAMP was blocked by n-(2-(Methylamino)ethyl)-5-isoquinolinesulfonic dihydrochloride (H8), an inhibitor of protein kinase A. H8 did not affect IgM secretion induced by IL-6. Cyclic AMP 48-52 interleukin 6 Homo sapiens 215-219 2165096-4 1990 The inhibitory effect of elevated intracellular cAMP was blocked by n-(2-(Methylamino)ethyl)-5-isoquinolinesulfonic dihydrochloride (H8), an inhibitor of protein kinase A. H8 did not affect IgM secretion induced by IL-6. N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide 133-135 interleukin 6 Homo sapiens 215-219 2165096-5 1990 In contrast, the addition of 1-(5-isoquinolinesulfonyl)-2-methylpiperizine dihydrochloride (H7), an inhibitor of protein kinase C activity, markedly inhibited IL-6-stimulated IgM production by SKW6.4 cells. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 92-94 interleukin 6 Homo sapiens 159-163 2165096-9 1990 When added to PMA-stimulated SKW6.4 cells, IL-6 stimulated additional IgM production. Tetradecanoylphorbol Acetate 14-17 interleukin 6 Homo sapiens 43-47 2252806-6 1990 IL-6 production was significantly reduced in the presence of Cuprophan (151 +/- 45 pg/ml), Hemophan (167 +/- 6 pg/ml), and polyacrylonitrile (108 +/- 33 pg/ml) when compared with polystyrole (724 +/- 34 pg/ml). Hemophan 91-99 interleukin 6 Homo sapiens 0-4 2194956-4 1990 Dexamethasone reduced interleukin-6 secretion, the PMNL response, and bacterial clearance. Dexamethasone 0-13 interleukin 6 Homo sapiens 22-35 2341719-6 1990 We suggest that a non-calcium-dependent, IL-6 regulatory factor, absent or inactive in verapamil-treated cultures, inhibits IL-6 gene activation in mitogen-stimulated PBMC. Calcium 22-29 interleukin 6 Homo sapiens 41-45 2191052-3 1990 The hallmark of IL-6 gene regulation is its induction by inflammation-associated cytokines, bacterial products, virus infection, and activation of any of the three major signal transduction pathways (diacylglycerol-, cAMP-, and Ca(++)-activated). Cyclic AMP 217-221 interleukin 6 Homo sapiens 16-20 19256129-3 1990 In this review we refer to the interleukin-1, interleukin-6 and tumor necrosis factor because of their elevated basal levels in acute and chronic hepatopaties and in response to lipopolisacharide mainly in alcoholic liver disease. lipopolisacharide 178-195 interleukin 6 Homo sapiens 46-59 2341719-6 1990 We suggest that a non-calcium-dependent, IL-6 regulatory factor, absent or inactive in verapamil-treated cultures, inhibits IL-6 gene activation in mitogen-stimulated PBMC. Calcium 22-29 interleukin 6 Homo sapiens 124-128 1693429-5 1990 The IL-6-R was functional, as [3H]thymidine incorporation by AIDS-KS cells increased significantly after exposure to human recombinant IL-6 (hrIL-6) at greater than 10 units/ml. Tritium 31-33 interleukin 6 Homo sapiens 4-8 2111442-1 1990 The interleukin-6 (IL-6) promoter is rapidly and transiently activated with other cytokines, including IL-1, tumor necrosis factor, and platelet-derived growth factor, as well as phorbol esters and agents that increase intracellular cyclic AMP. Cyclic AMP 233-243 interleukin 6 Homo sapiens 4-17 2111442-1 1990 The interleukin-6 (IL-6) promoter is rapidly and transiently activated with other cytokines, including IL-1, tumor necrosis factor, and platelet-derived growth factor, as well as phorbol esters and agents that increase intracellular cyclic AMP. Cyclic AMP 233-243 interleukin 6 Homo sapiens 19-23 1693429-6 1990 When AIDS-KS cells (EKS3) were exposed to IL-6 antisense oligonucleotide, cellular proliferation decreased by nearly two-thirds, with a corresponding decrease in the production of IL-6. Oligonucleotides 57-72 interleukin 6 Homo sapiens 42-46 1693429-6 1990 When AIDS-KS cells (EKS3) were exposed to IL-6 antisense oligonucleotide, cellular proliferation decreased by nearly two-thirds, with a corresponding decrease in the production of IL-6. Oligonucleotides 57-72 interleukin 6 Homo sapiens 180-184 1693429-7 1990 The decrease from IL-6 antisense in AIDS-KS cell proliferation was reversed by the addition of hrIL-6. hril-6 95-101 interleukin 6 Homo sapiens 18-22 2339118-0 1990 In vitro activation of heat shock transcription factor DNA-binding by calcium and biochemical conditions that affect protein conformation. Calcium 70-77 interleukin 6 Homo sapiens 23-54 1716487-2 1990 In this study, we report the effects of prostaglandin E2 (PGE2), and two other cAMP-elevating agents, dibutyryl cAMP and 3-isobutyl-1-methyl-xanthine, on the in vitro LPS-induced production of IL 6, IL 1 alpha, IL 1 beta and TNF alpha by human monocytes. Dinoprostone 40-56 interleukin 6 Homo sapiens 193-197 1716487-7 1990 Kinetic analysis showed that the potentiating effect of cAMP on IL 6 production, along with its inhibiting effect on TNF alpha production, could be seen as early as 1 hr after LPS stimulation. Cyclic AMP 56-60 interleukin 6 Homo sapiens 64-68 1716487-8 1990 These results demonstrate that IL 6, TNF alpha, IL 1 alpha and IL 1 beta production can be differently modulated by an agent, PGE2, which is produced simultaneously by LPS-stimulated monocytes. Dinoprostone 126-130 interleukin 6 Homo sapiens 31-35 2113479-4 1990 Constitutive production of IL 6 in early passage lines could be enhanced by the phorbol ester phorbol 12-myristate 13-acetate (PMA) and recombinant (r)IL 4 but not by rIL 1 alpha or rIL 1 beta. Tetradecanoylphorbol Acetate 94-125 interleukin 6 Homo sapiens 27-31 2113479-4 1990 Constitutive production of IL 6 in early passage lines could be enhanced by the phorbol ester phorbol 12-myristate 13-acetate (PMA) and recombinant (r)IL 4 but not by rIL 1 alpha or rIL 1 beta. Tetradecanoylphorbol Acetate 127-130 interleukin 6 Homo sapiens 27-31 2162322-5 1990 The IL-6 activity in culture supernatants of EBV-transformed B cells, though much less than that of lipopolysaccharide (LPS)-stimulated monocytes, was increased by the addition of phorbol myristate acetate. Tetradecanoylphorbol Acetate 180-205 interleukin 6 Homo sapiens 4-8 2163835-2 1990 Treatment of HepG2 cells with dexamethasone led to a time- and dose-dependent up-regulation of IL-6-receptor mRNA levels. Dexamethasone 30-43 interleukin 6 Homo sapiens 95-99 2163835-3 1990 By the use of cross-linking this effect was also seen at the protein level, where all three IL-6-binding complexes increased upon incubation of HepG2 cells with dexamethasone. Dexamethasone 161-174 interleukin 6 Homo sapiens 92-96 2163835-4 1990 Under conditions of IL-6-receptor up-regulation by dexamethasone, gamma-fibrinogen mRNA induction by IL-6 is stronger and occurs earlier than without dexamethasone. Dexamethasone 51-64 interleukin 6 Homo sapiens 20-24 2163835-4 1990 Under conditions of IL-6-receptor up-regulation by dexamethasone, gamma-fibrinogen mRNA induction by IL-6 is stronger and occurs earlier than without dexamethasone. Dexamethasone 51-64 interleukin 6 Homo sapiens 101-105 2183031-6 1990 Mutations in the NF-kappa B-binding site abolished inducibility of IL-6 promoter-cat constructs in U-937 cells by lipopolysaccharide, tumor necrosis factor alpha, the double-stranded RNA poly(IC), or phytohemagglutinin and in HeLa cells by tumor necrosis factor alpha and drastically reduced but did not completely eliminate inducibility in HeLa cells stimulated by double-stranded RNA poly(IC) or phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 398-429 interleukin 6 Homo sapiens 67-71 2339118-3 1990 We have used a HeLa cell-free system in which HSF DNA-binding is activated by conditions that affect protein conformation, including increasing concentrations of hydrogen ions, urea, or nonionic detergents. Hydrogen 162-170 interleukin 6 Homo sapiens 46-49 2339118-3 1990 We have used a HeLa cell-free system in which HSF DNA-binding is activated by conditions that affect protein conformation, including increasing concentrations of hydrogen ions, urea, or nonionic detergents. Urea 177-181 interleukin 6 Homo sapiens 46-49 2339118-4 1990 Treatment with calcium ions also results in a concentration- and time-dependent activation of HSF in vitro. Calcium 15-22 interleukin 6 Homo sapiens 94-97 2346722-6 1990 IL-1 alpha, IL-1 beta and TNF-alpha enhanced 3H-TdR uptake in myeloma cells through IL-6, as antibodies to IL-6 completely abolished the DNA synthesis induced by culture supernatants of MC exposed to these cytokines. Tritium 45-47 interleukin 6 Homo sapiens 84-88 2332497-7 1990 The 23-25- and 28-30-kD IL-6 species could be readily detected in SDS-PAGE immunoblots performed directly on 10-microliters aliquots of AF from patients with intraamniotic infection. Sodium Dodecyl Sulfate 66-69 interleukin 6 Homo sapiens 24-28 2107032-9 1990 This study suggests that the trace metals copper and zinc may play important and possibly distinct roles in regulating leukocyte secretion of TNF, IL-1 beta, and IL-6. Copper 42-48 interleukin 6 Homo sapiens 162-166 2346722-6 1990 IL-1 alpha, IL-1 beta and TNF-alpha enhanced 3H-TdR uptake in myeloma cells through IL-6, as antibodies to IL-6 completely abolished the DNA synthesis induced by culture supernatants of MC exposed to these cytokines. Tritium 45-47 interleukin 6 Homo sapiens 107-111 2107032-2 1990 The secretion of interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) was inhibited by copper under the same culture conditions, while zinc stimulated IL-1 beta secretion in a concentration-dependent manner and had no effect on leukocyte IL-6 release. Copper 90-96 interleukin 6 Homo sapiens 52-65 2157429-4 1990 Drugs raising cellular cAMP level or cAMP analogues augmented IL1-mediated IL6 mRNA expression but much less. Cyclic AMP 23-27 interleukin 6 Homo sapiens 75-78 2107032-2 1990 The secretion of interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) was inhibited by copper under the same culture conditions, while zinc stimulated IL-1 beta secretion in a concentration-dependent manner and had no effect on leukocyte IL-6 release. Copper 90-96 interleukin 6 Homo sapiens 67-71 2107032-2 1990 The secretion of interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) was inhibited by copper under the same culture conditions, while zinc stimulated IL-1 beta secretion in a concentration-dependent manner and had no effect on leukocyte IL-6 release. Copper 90-96 interleukin 6 Homo sapiens 241-245 2157217-4 1990 This effect was confirmed by Scatchard analysis of binding experiments, using [35S]methionine and [35S]cysteine metabolically labeled IL-6. Sulfur-35 99-102 interleukin 6 Homo sapiens 134-138 2157217-4 1990 This effect was confirmed by Scatchard analysis of binding experiments, using [35S]methionine and [35S]cysteine metabolically labeled IL-6. Cysteine 103-111 interleukin 6 Homo sapiens 134-138 2347366-2 1990 Expression of IL 6 in transfected cells was highly inducible by heavy metals like cadmium as measured at mRNA and protein levels. Cadmium 82-89 interleukin 6 Homo sapiens 14-18 2341859-6 1990 It is concluded that MTP-PE in liposomes generates increased amounts of IL-6 measurable in serum several hours after administration. mifamurtide 21-27 interleukin 6 Homo sapiens 72-76 2188060-2 1990 The hallmark of IL-6 gene regulation is its induction in many different tissues by inflammation-associated cytokines, bacterial products, virus infection and by activation of any of the three major signal transduction pathways (diacylglycerol, cAMP and Ca2(+)-activated). Cyclic AMP 244-248 interleukin 6 Homo sapiens 16-20 2157429-4 1990 Drugs raising cellular cAMP level or cAMP analogues augmented IL1-mediated IL6 mRNA expression but much less. Cyclic AMP 37-41 interleukin 6 Homo sapiens 75-78 2157429-5 1990 Although cAMP is not directly involved in the IL1 action, cAMP thus has a modulatory effect on IL1-mediated IL6 gene activation. Cyclic AMP 9-13 interleukin 6 Homo sapiens 108-111 2157429-5 1990 Although cAMP is not directly involved in the IL1 action, cAMP thus has a modulatory effect on IL1-mediated IL6 gene activation. Cyclic AMP 58-62 interleukin 6 Homo sapiens 108-111 2104896-9 1990 Analysis of hormonal influences on chondrocyte IL-6 production showed that testosterone and estradiol synergized with IL-1 in the induction of IL-6. Testosterone 75-87 interleukin 6 Homo sapiens 47-51 2310829-1 1990 Interleukin-6 (IL-6), a multifunctional cytokine produced in monocytes, fibroblasts, endothelial cells, and keratinocytes, is induced by a variety of stimulating signals, including lipopolysaccharide (LPS), poly (I), poly (C), IL-1, tumor necrosis factor (TNF), and platelet-derived growth factor. Poly I 207-215 interleukin 6 Homo sapiens 0-13 2310829-1 1990 Interleukin-6 (IL-6), a multifunctional cytokine produced in monocytes, fibroblasts, endothelial cells, and keratinocytes, is induced by a variety of stimulating signals, including lipopolysaccharide (LPS), poly (I), poly (C), IL-1, tumor necrosis factor (TNF), and platelet-derived growth factor. Poly I 207-215 interleukin 6 Homo sapiens 15-19 2310829-6 1990 As judged by sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reducing conditions, IL-6 species of relative molecular mass of 19 to 26 Kd could be specifically immunoprecipitated from supernatants of IL-1-induced monocytes. Sodium Dodecyl Sulfate 13-35 interleukin 6 Homo sapiens 98-102 2407240-4 1990 Interleukin 6 production is not inhibited by prostaglandin E2 but may be partially dependent on prostaglandin E2 production. Dinoprostone 96-112 interleukin 6 Homo sapiens 0-13 2407240-5 1990 Using an antiserum to interleukin 6 we have demonstrated that the production of prostaglandin E2 under basal conditions and in response to interleukin 1 is probably not mediated by interleukin 6. Dinoprostone 80-96 interleukin 6 Homo sapiens 22-35 2107353-7 1990 However, when PDGF-BB or -AB was combined with IL-1 beta or IL-6, prostanoid generation by HMC was synergistically increased up to 222-fold (IL-1 beta) or 12-fold (IL-6) above the control values, with the induction of PGE2 greater than 6-keto-PGF1 alpha greater than PGF2 alpha much greater than TXB2. Prostaglandins 66-76 interleukin 6 Homo sapiens 60-64 2107353-7 1990 However, when PDGF-BB or -AB was combined with IL-1 beta or IL-6, prostanoid generation by HMC was synergistically increased up to 222-fold (IL-1 beta) or 12-fold (IL-6) above the control values, with the induction of PGE2 greater than 6-keto-PGF1 alpha greater than PGF2 alpha much greater than TXB2. Prostaglandins 66-76 interleukin 6 Homo sapiens 164-168 2107353-7 1990 However, when PDGF-BB or -AB was combined with IL-1 beta or IL-6, prostanoid generation by HMC was synergistically increased up to 222-fold (IL-1 beta) or 12-fold (IL-6) above the control values, with the induction of PGE2 greater than 6-keto-PGF1 alpha greater than PGF2 alpha much greater than TXB2. Dinoprostone 218-222 interleukin 6 Homo sapiens 60-64 1689350-7 1990 In the whole blood culture, it was shown that expression of IL-6 mRNA by monocytes was inhibited by dexamethasone, but not by cyclosporin A. Dexamethasone 100-113 interleukin 6 Homo sapiens 60-64 1689350-7 1990 In the whole blood culture, it was shown that expression of IL-6 mRNA by monocytes was inhibited by dexamethasone, but not by cyclosporin A. Cyclosporine 126-139 interleukin 6 Homo sapiens 60-64 2104896-9 1990 Analysis of hormonal influences on chondrocyte IL-6 production showed that testosterone and estradiol synergized with IL-1 in the induction of IL-6. Testosterone 75-87 interleukin 6 Homo sapiens 143-147 2104896-9 1990 Analysis of hormonal influences on chondrocyte IL-6 production showed that testosterone and estradiol synergized with IL-1 in the induction of IL-6. Estradiol 92-101 interleukin 6 Homo sapiens 47-51 2104896-9 1990 Analysis of hormonal influences on chondrocyte IL-6 production showed that testosterone and estradiol synergized with IL-1 in the induction of IL-6. Estradiol 92-101 interleukin 6 Homo sapiens 143-147 2104896-10 1990 Hydrocortisone, at 10 ng/ml, reduced IL-1-induced IL-6 production by more than 50%. Hydrocortisone 0-14 interleukin 6 Homo sapiens 50-54 2105658-0 1990 Interleukin 6 stimulates hepatic glucose release from prelabeled glycogen pools. Glucose 33-40 interleukin 6 Homo sapiens 0-13 2105658-4 1990 After the addition of a highly concentrated human monocyte-conditioned medium (MCM) or various cytokines to these prelabeled cells, [14C]glucose release was stimulated by MCM and recombinant human interleukin 6 (IL-6) but was not stimulated by other cytokines tested. Glucose 137-144 interleukin 6 Homo sapiens 197-210 2105658-4 1990 After the addition of a highly concentrated human monocyte-conditioned medium (MCM) or various cytokines to these prelabeled cells, [14C]glucose release was stimulated by MCM and recombinant human interleukin 6 (IL-6) but was not stimulated by other cytokines tested. Glucose 137-144 interleukin 6 Homo sapiens 212-216 33972660-8 2021 Importantly, FMRP could promote the IL-6-mediated translation of STAT3, and serine 114 of FMRP is identified as a potential phosphorylation site required for IL-6-mediated STAT3 translation. Serine 76-82 interleukin 6 Homo sapiens 158-162 2103309-6 1990 This activity was increased (1.7 to 2.6-fold) when SMC were pretreated with IL-1 or calcium ionophore A23187 for 48 h, and was completely blocked by rabbit anti-human IL-6 antibodies. Calcium 84-91 interleukin 6 Homo sapiens 167-171 2294005-5 1990 IL-6 production was stimulated by phorbol myristate acetate (10-100 nM) approximately 2-fold and by lipopolysaccharide (0.001-10.0 micrograms/ml) 4-fold during 4-h incubations. Tetradecanoylphorbol Acetate 34-59 interleukin 6 Homo sapiens 0-4 1690177-0 1990 Secretion of interleukin-6 (IL-6) by human monocytes stimulated by muramyl dipeptide and tumour necrosis factor alpha. Dipeptides 75-84 interleukin 6 Homo sapiens 13-26 1690177-0 1990 Secretion of interleukin-6 (IL-6) by human monocytes stimulated by muramyl dipeptide and tumour necrosis factor alpha. Dipeptides 75-84 interleukin 6 Homo sapiens 28-32 2289988-6 1990 Lactate correlated with C3a and C4a, with elastase, and in particular, with IL-6, whereas it did not correlate with either factor XII or prekallikrein. Lactic Acid 0-7 interleukin 6 Homo sapiens 76-80 2137272-2 1990 As IL-6 stimulates antigen-activated T cells to release IL-2, we examined the influence of CsA on IL-6 gene expression and IL-6-supported T cell proliferation. Cyclosporine 91-94 interleukin 6 Homo sapiens 98-102 2137272-2 1990 As IL-6 stimulates antigen-activated T cells to release IL-2, we examined the influence of CsA on IL-6 gene expression and IL-6-supported T cell proliferation. Cyclosporine 91-94 interleukin 6 Homo sapiens 98-102 2137272-4 1990 In fact, increased IL-6 gene transcription and increased release of IL-6 bioactivity were detected using mitogen-activated PBMCs cultured with CsA doses (200-800 ng/ml) only slightly in excess of the minimal antiproliferative dose. Cyclosporine 143-146 interleukin 6 Homo sapiens 19-23 2137272-4 1990 In fact, increased IL-6 gene transcription and increased release of IL-6 bioactivity were detected using mitogen-activated PBMCs cultured with CsA doses (200-800 ng/ml) only slightly in excess of the minimal antiproliferative dose. Cyclosporine 143-146 interleukin 6 Homo sapiens 68-72 2137272-5 1990 CsA completely abrogated the IL-6-stimulated proliferative responses of macrophage-depleted T cells stimulated with polyvalent anti-CD3 monoclonal antibodies. Cyclosporine 0-3 interleukin 6 Homo sapiens 29-33 2137272-7 1990 As IL-6 fosters B cell activation and growth of EBV-transformed B cells, excessive CsA doses may support development of EBV-transformed B cell lymphomas via superinduction of the IL-6 gene. Cyclosporine 83-86 interleukin 6 Homo sapiens 179-183 33805509-5 2021 Five studies of dietary fiber supplementation showed an inconclusive positive effect on PBUT levels and a significant positive effect on the reduction in inflammatory markers (interleukin-6 reduction: standardized difference in means -1.18; 95% confidence interval -1.45 to -0.9 for dietary fiber supplementation vs. control; p < 0.001). Dietary Fiber 24-29 interleukin 6 Homo sapiens 176-189 33773263-6 2021 Aryl thioether derivative 7f significantly reduced STAT3 phosphorylation (23%) and its nuclear localisation (16%) at 10 muM in tumorigenic LPCs, implicating the IL-6/JAK/STAT3 axis is central in the mode of action of our derivatives. Sulfides 5-14 interleukin 6 Homo sapiens 161-165 33768559-9 2021 Further, a correlation between IL-6 and platelet 5-HT has been observed in patients. Serotonin 49-53 interleukin 6 Homo sapiens 31-35 32757312-6 2021 Physiologically based pharmacokinetics (PBPK) simulations were conducted to evaluate the potential impact of IL-6 on the digoxin pharmacokinetics profile and brain exposure by decreasing BBB ABCB1 efflux activity. Digoxin 121-128 interleukin 6 Homo sapiens 109-113 32757312-9 2021 PBPK simulation showed that, if we only consider the impact of IL-6 on ABCB1-transporter, the modification of the digoxin pharmacokinetics profile and brain exposure is slight. Digoxin 114-121 interleukin 6 Homo sapiens 63-67 33793375-2 2021 As mesalazine (5-ASA) could be involved in ER stress, proinflammatory and ER stress-associated cytokines and markers were measured.Results: Mesalazine (5-ASA) suppressed IL-6 mRNA in healthy donors and in HLA-B27+ and HLA-B27- patients but did not lead to induction and secretion of IL-1beta. Mesalamine 140-150 interleukin 6 Homo sapiens 170-174 33793375-2 2021 As mesalazine (5-ASA) could be involved in ER stress, proinflammatory and ER stress-associated cytokines and markers were measured.Results: Mesalazine (5-ASA) suppressed IL-6 mRNA in healthy donors and in HLA-B27+ and HLA-B27- patients but did not lead to induction and secretion of IL-1beta. Mesalamine 152-157 interleukin 6 Homo sapiens 170-174 33822421-6 2021 Moreover, HUVECs pretreatment with silibinin reduced TNF-alpha-induced gene expression of the proinflammatory genes IL-6 and MCP-1, as well as of PAI-1, a critical factor in coagulopathy and thrombosis, and of ET-1, a peptide involved in hemostatic vasoconstriction. Silybin 35-44 interleukin 6 Homo sapiens 116-120 33812377-9 2021 Finally, the uptake of PMP derived from PAR-4 treated PGC platelets into THP-1 transformed macrophages promoted a marked increase of IL-6 release compared to PMP derived from GGC through the activation of the NF-kB pathway. 2-(4-methoxyphenoxy)propanoic acid 23-26 interleukin 6 Homo sapiens 133-137 33798839-7 2021 Metformin exposure was also associated with decreased levels of the inflammatory cytokines TNFalpha, IL-1a, IL-1b and IL-6 in serum, placenta and omental tissue taken from pregnant women. Metformin 0-9 interleukin 6 Homo sapiens 118-122 33781216-8 2021 We analyzed the association between the IL-6 at the initial assessment and development of hypoxemia during follow up and determined the cut-off of the IL-6 able to predict the development of hypoxemia requiring oxygen therapy. Oxygen 211-217 interleukin 6 Homo sapiens 151-155 33771121-0 2021 Mutant glucocorticoid receptor binding elements on the interleukin-6 promoter regulate dexamethasone effects. Dexamethasone 87-100 interleukin 6 Homo sapiens 55-68 33805509-5 2021 Five studies of dietary fiber supplementation showed an inconclusive positive effect on PBUT levels and a significant positive effect on the reduction in inflammatory markers (interleukin-6 reduction: standardized difference in means -1.18; 95% confidence interval -1.45 to -0.9 for dietary fiber supplementation vs. control; p < 0.001). Dietary Fiber 16-29 interleukin 6 Homo sapiens 176-189 33777140-5 2021 We found the following: (1) under the high-glucose condition, the HSF cell viability, the expression of TIMP-2 mRNA, and the collagen levels were reduced, while the apoptosis rate and the expression of MMP-2 mRNA increased (P < 0.05). Glucose 43-50 interleukin 6 Homo sapiens 66-69 33799840-2 2021 The aim of this study is to investigate the effects of hydrogen nano-bubble water (HW) on ROS generation, adipogenesis, and interleukin-6 (IL-6) secretion in hydrogen peroxide (H2O2) or phorbol 12-myristate 13-acetate (PMA)-stimulated OP9 adipocytes, and three-dimensional (3D) subcutaneous adipose equivalents. Hydrogen Peroxide 158-175 interleukin 6 Homo sapiens 124-137 33799840-2 2021 The aim of this study is to investigate the effects of hydrogen nano-bubble water (HW) on ROS generation, adipogenesis, and interleukin-6 (IL-6) secretion in hydrogen peroxide (H2O2) or phorbol 12-myristate 13-acetate (PMA)-stimulated OP9 adipocytes, and three-dimensional (3D) subcutaneous adipose equivalents. Hydrogen Peroxide 158-175 interleukin 6 Homo sapiens 139-143 33799840-2 2021 The aim of this study is to investigate the effects of hydrogen nano-bubble water (HW) on ROS generation, adipogenesis, and interleukin-6 (IL-6) secretion in hydrogen peroxide (H2O2) or phorbol 12-myristate 13-acetate (PMA)-stimulated OP9 adipocytes, and three-dimensional (3D) subcutaneous adipose equivalents. Tetradecanoylphorbol Acetate 186-217 interleukin 6 Homo sapiens 139-143 33791202-3 2021 In our study, we found that SaOS-2 and SOSP-9607 osteosarcoma cells became less sensitive to lobaplatin after treatment with exogenous interleukin (IL)-6. lobaplatin 93-103 interleukin 6 Homo sapiens 135-153 33806019-0 2021 Targeting the IL-6/STAT3 Signalling Cascade to Reverse Tamoxifen Resistance in Estrogen Receptor Positive Breast Cancer. Tamoxifen 55-64 interleukin 6 Homo sapiens 14-18 33804152-8 2021 13R,20-diHDHA increased reactive oxygen species (ROS) production, and the generated ROS reduced the phosphorylation of nuclear signal transducer and activator of transcription 3 (Stat3) and the secretion of IL-6 by mammospheres. Reactive Oxygen Species 84-87 interleukin 6 Homo sapiens 207-211 33799840-0 2021 Hydrogen Nano-Bubble Water Suppresses ROS Generation, Adipogenesis, and Interleukin-6 Secretion in Hydrogen-Peroxide- or PMA-Stimulated Adipocytes and Three-Dimensional Subcutaneous Adipose Equivalents. Hydrogen 0-8 interleukin 6 Homo sapiens 72-85 33799840-0 2021 Hydrogen Nano-Bubble Water Suppresses ROS Generation, Adipogenesis, and Interleukin-6 Secretion in Hydrogen-Peroxide- or PMA-Stimulated Adipocytes and Three-Dimensional Subcutaneous Adipose Equivalents. Water 21-26 interleukin 6 Homo sapiens 72-85 33799840-0 2021 Hydrogen Nano-Bubble Water Suppresses ROS Generation, Adipogenesis, and Interleukin-6 Secretion in Hydrogen-Peroxide- or PMA-Stimulated Adipocytes and Three-Dimensional Subcutaneous Adipose Equivalents. Tetradecanoylphorbol Acetate 121-124 interleukin 6 Homo sapiens 72-85 33777140-6 2021 (2) In the high-glucose + PDC group, the PDC reversed the changes in the collagen level, viability, and apoptosis rate of the HSF cells caused by high glucose, with the expression of protein and TIMP-2 mRNA increased and the level of MMP-2 mRNA decreased (P < 0.05). Glucose 16-23 interleukin 6 Homo sapiens 126-129 33777140-6 2021 (2) In the high-glucose + PDC group, the PDC reversed the changes in the collagen level, viability, and apoptosis rate of the HSF cells caused by high glucose, with the expression of protein and TIMP-2 mRNA increased and the level of MMP-2 mRNA decreased (P < 0.05). Glucose 151-158 interleukin 6 Homo sapiens 126-129 33777140-7 2021 This is the first time attempting to reveal that PDC can exhibit protective effects on HSF under high-glucose conditions, which may be related to the upregulation of the TIMP-2 expression and inhibition of the MMP-2 expression. Glucose 102-109 interleukin 6 Homo sapiens 87-90 31412862-6 2019 BBR also caused a marked reduction in the secretion of proinflammatory cytokines, Interleukin-1alpha (IL-1alpha), Interleukin-1beta (IL-1beta), Interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha). Berberine 0-3 interleukin 6 Homo sapiens 144-157 33236293-7 2021 Serum zinc and Zn/Cu ratio levels had a negative relationship with acute phase markers such as IL-6, Erythrocyte Sedimentation Rate, procalcitonin and C-reactive Protein. Zinc 15-17 interleukin 6 Homo sapiens 95-99 33236293-7 2021 Serum zinc and Zn/Cu ratio levels had a negative relationship with acute phase markers such as IL-6, Erythrocyte Sedimentation Rate, procalcitonin and C-reactive Protein. Copper 18-20 interleukin 6 Homo sapiens 95-99 32857851-0 2020 Berberine functions as a negative regulator in lipopolysaccharide -induced sepsis by suppressing NF-kappaB and IL-6 mediated STAT3 activation. Berberine 0-9 interleukin 6 Homo sapiens 111-115 32857851-9 2020 We further found that berberine inhibited the expression of tumor necrosis factor (TNF)-alpha, interleukin-(IL)-1beta, and IL-6 via suppressing nuclear factor kappa B subunit 1 (NF-kappaB) signaling activation. Berberine 22-31 interleukin 6 Homo sapiens 123-127 33232407-10 2021 CONCLUSION: Low-ratio n-6/n-3 PUFA supplementation could decrease significantly the concentration of serum TNF-alpha and IL-6, but not decrease CRP concentration. Nitrogen 22-23 interleukin 6 Homo sapiens 121-125 31412862-6 2019 BBR also caused a marked reduction in the secretion of proinflammatory cytokines, Interleukin-1alpha (IL-1alpha), Interleukin-1beta (IL-1beta), Interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha). Berberine 0-3 interleukin 6 Homo sapiens 159-163 24721145-1 2015 BACKGROUND & AIMS: The n-3 polyunsaturated fatty acids (PUFAs) and the inflammatory indicator, interleukin-6 (IL-6), have been implied in the development of renal dysfunction. Adenosine Monophosphate 12-15 interleukin 6 Homo sapiens 99-112 26629143-6 2015 RESULTS: The Th17 cell percentages and the serum concentrations of IL-6, IL-17, IL-22 and TGF-beta in the Aci and Aci + Glyc groups were significantly higher than those in the control group before treatments (P < 0.05) and were significantly declined after the treatments (P < 0.05), but to a higher extend in the Aci + Glyc group (P < 0.05). Acitretin 106-109 interleukin 6 Homo sapiens 67-71 24721145-1 2015 BACKGROUND & AIMS: The n-3 polyunsaturated fatty acids (PUFAs) and the inflammatory indicator, interleukin-6 (IL-6), have been implied in the development of renal dysfunction. Adenosine Monophosphate 12-15 interleukin 6 Homo sapiens 114-118 25346502-9 2014 RESULTS: The expression of TLR2, TRAF-6, NF-kappaB p65, and the proinflammatory cytokines, TNF-alpha and IL-6, were significantly increased after alcohol exposure in EA.hy926 endothelial cells. Alcohols 146-153 interleukin 6 Homo sapiens 105-109 23861935-7 2013 Stimulation with the corresponding agonists Pam3CSK4, poly(I:C), LPS, R-837 and iE-DAP, respectively, induced IL-6, IL-8 and GM-CSF release and up-regulation of ICAM-1 and HLA-DR, while poly(I:C) also affected the release of eotaxin and RANTES. alpha,beta-diacryloxypropionic acid 83-86 interleukin 6 Homo sapiens 110-114 23448998-5 2013 Estradiol correlated positively with interleukin-6 (IL-6), weight, body mass index (BMI), insulin, homocysteine, and homeostasis model assessment of insulin resistance (HOMA-IR). Estradiol 0-9 interleukin 6 Homo sapiens 37-50 23448998-5 2013 Estradiol correlated positively with interleukin-6 (IL-6), weight, body mass index (BMI), insulin, homocysteine, and homeostasis model assessment of insulin resistance (HOMA-IR). Estradiol 0-9 interleukin 6 Homo sapiens 52-56 9860036-11 1998 CONCLUSION: These results suggest that the clinical activity of mometasone furoate nasal spray in seasonal allergic rhinitis is likely due, in part, to a reduction in the levels of histamine in nasal secretions related to the early phase response, and reductions in IL-6, IL-8, and eosinophils during the late phase response. Histamine 181-190 interleukin 6 Homo sapiens 266-270 15888106-7 2005 Exogenous PGE2 significantly suppressed IL-1alpha-induced IL-6 production. Dinoprostone 10-14 interleukin 6 Homo sapiens 58-62 15888106-8 2005 Butaprost, a selective EP2 agonist, and ONO-AE1-329, a selective EP4 agonist, significantly inhibited IL-1alpha-induced IL-6 production, although 17-phenyl-omega-trinor PGE2, an EP1 agonist, and ONO-AP-324, an EP3 agonist, did not affect it. ONO-AE1-329 40-51 interleukin 6 Homo sapiens 120-124 15888106-10 2005 CONCLUSIONS: We suggest that PGE2 downregulates IL-1alpha-induced IL-6 production via EP2/EP4 receptors in human PDL cells. Dinoprostone 29-33 interleukin 6 Homo sapiens 66-70 15888106-0 2005 Prostaglandin E2 (PGE2) downregulates interleukin (IL)-1alpha-induced IL-6 production via EP2/EP4 subtypes of PGE2 receptors in human periodontal ligament cells. Dinoprostone 0-16 interleukin 6 Homo sapiens 70-74 15888106-0 2005 Prostaglandin E2 (PGE2) downregulates interleukin (IL)-1alpha-induced IL-6 production via EP2/EP4 subtypes of PGE2 receptors in human periodontal ligament cells. Dinoprostone 18-22 interleukin 6 Homo sapiens 70-74 15888106-2 2005 In the present study, we examined whether PGE2 regulated interleukin (IL)-1alpha-induced IL-6 production in human periodontal ligament (PDL) cells and if so, which subtypes of PGE2 receptors were involved. Dinoprostone 42-46 interleukin 6 Homo sapiens 89-93 34781065-8 2022 TCDD-treated PBMCs increased the migration capacity of MenSCs and up-regulated MCP-1 and IL-6 levels in the PBMCs/MenSCs co-culture (P <= 0.01-0.0001). Polychlorinated Dibenzodioxins 0-4 interleukin 6 Homo sapiens 89-93 34078115-6 2022 IL-6 inhibitors (sirukumab, tocilizumab, sarilumab) significantly enhance metabolism via CYP2C9 (s-warfarin), CYP2C19 (omeprazole), and CYP3A4 (simvastatin, midazolam) and reduce metabolism via CYP1A2 (caffeine). Omeprazole 119-129 interleukin 6 Homo sapiens 0-4 34781065-6 2022 The impact of TCDD-treated PBMCs on the migration capacity of menstrual blood-derived stromal stem cells (MenSCs) and monocyte chemoattractant protein-1 (MCP-1) and IL-6 production was determined. Polychlorinated Dibenzodioxins 14-18 interleukin 6 Homo sapiens 165-169 34781065-7 2022 Here, we found that AHR and IDO1 expression levels were lower in endometriosis PBMCs; however, TCDD treatment increased AHR, FOXP3, IDO1, IL-6, and Treg levels in the endometriosis group (P <= 0.05-0.0001). Polychlorinated Dibenzodioxins 95-99 interleukin 6 Homo sapiens 138-142 34785106-9 2022 Furthermore, ISL promoted fatty acid metabolism via induction in the expression of PGC-1alpha-target genes PPARalpha, CPT1alpha, and ACADs, and inhibited the ROS, TNF-alpha, IL-1beta, and IL-6 expression. Fatty Acids 26-36 interleukin 6 Homo sapiens 188-192 34968467-0 2022 Berberine inhibits gastric cancer development and progression by regulating the JAK2/STAT3 pathway and downregulating IL-6. Berberine 0-9 interleukin 6 Homo sapiens 118-122 34968467-10 2022 Mechanistically, these findings imply that BBR inhibits GC cell proliferation by modulating the signaling pathways related to IL-6/JAK2/STAT3. Berberine 43-46 interleukin 6 Homo sapiens 126-130 34902346-9 2022 Kynurenine and the KYN/TRP ratio significantly correlated with IL-6 (rho = 0.441 and 0.448, p-values < 0.001). Tryptophan 23-26 interleukin 6 Homo sapiens 63-67 34678476-0 2022 Association between Interleukin-6 and vitamin D serum levels in patients with obstructive sleep apnea syndrome and impact of long-term continuous positive airway pressure therapy on biomarker levels. Vitamin D 38-47 interleukin 6 Homo sapiens 20-33 34678476-3 2022 Serum 25(OH)D levels have been negatively correlated with serum IL-6 levels in patients with chronic inflammation. 25(oh)d 6-13 interleukin 6 Homo sapiens 64-68 34678476-5 2022 We aimed to compare the serum 25(OH)D and IL-6 levels between OSAS patients and controls, examine a possible correlation between 25(OH)D and IL-6 levels and the changes of their concentrations after twelve months of CPAP therapy in OSAS patients. 25(oh)d 129-136 interleukin 6 Homo sapiens 141-145 34332882-0 2022 Prevention of IL-6 signaling ameliorates toluene diisocyanate-induced steroid-resistant asthma. Steroids 70-77 interleukin 6 Homo sapiens 14-18 34935398-9 2022 Conclusions During systemic inflammatory activation, interleukin-6 elevation is associated with reduced testosterone levels in males, possibly deriving from an enhanced androgen-to-estrogen conversion. Testosterone 104-116 interleukin 6 Homo sapiens 53-66 34922939-9 2022 The induction of ROS affected the level of proinflammatory cytokines interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha). Reactive Oxygen Species 17-20 interleukin 6 Homo sapiens 99-112 34922939-9 2022 The induction of ROS affected the level of proinflammatory cytokines interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha). Reactive Oxygen Species 17-20 interleukin 6 Homo sapiens 114-118 34378873-0 2022 Human umbilical cord-derived mesenchymal stem cells affect urea synthesis and the cell apoptosis of human induced hepatocytes by secreting IL-6 in a serum-free co-culture system. Urea 59-63 interleukin 6 Homo sapiens 139-143 34687791-6 2022 Depletion of IL-6Ralpha abolished IL-6 induced STAT3 phosphorylation at 705th tyrosine and tumor growth of HCC cells under sorafenib treatment. Tyrosine 78-86 interleukin 6 Homo sapiens 34-38 34455600-0 2022 The efficacy of soy isoflavones combined with soy protein on serum concentration of interleukin-6 and tumor necrosis factor-alpha among postmenopausal women? Isoflavones 20-31 interleukin 6 Homo sapiens 84-97 34715309-9 2022 But rapamycin could reverse the increasing expression of p-JNK/JNK, p-ERK/ERK and the release of IL-6 induced by GFP-SNCA Exo. Sirolimus 4-13 interleukin 6 Homo sapiens 97-101 34455600-3 2022 The present study aimed to summarize the effect of soy isoflavones and soy protein on circulating interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in postmenopausal women. Isoflavones 55-66 interleukin 6 Homo sapiens 98-111 34455600-3 2022 The present study aimed to summarize the effect of soy isoflavones and soy protein on circulating interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in postmenopausal women. Isoflavones 55-66 interleukin 6 Homo sapiens 113-117 34455600-9 2022 In subgroup analysis, soy isoflavones plus soy protein could increase the serum concentration of IL-6 in studies with soy isoflavones dose <=87 mg/d, cross-over design, weak quality, and studies on participants who had health risk factors or diseases. Isoflavones 26-37 interleukin 6 Homo sapiens 97-101 34455600-9 2022 In subgroup analysis, soy isoflavones plus soy protein could increase the serum concentration of IL-6 in studies with soy isoflavones dose <=87 mg/d, cross-over design, weak quality, and studies on participants who had health risk factors or diseases. Isoflavones 122-133 interleukin 6 Homo sapiens 97-101 34865992-8 2022 RESULTS: Our results revealed that IL-6 promoted the proliferation of PASMCs, but progesterone could reverse the adverse effect of IL-6. Progesterone 82-94 interleukin 6 Homo sapiens 131-135 34570917-17 2022 Both Amlexanox and BAY 11-7082 inhibited IFN-beta, TNF, and IL-6 production triggered by ISD and cyclic dinucleotides transfection. amlexanox 5-14 interleukin 6 Homo sapiens 60-64 34432333-0 2022 Elevated serum levels of TNF-alpha, IL-6, and IL-18 in chronic methamphetamine users. Methamphetamine 63-78 interleukin 6 Homo sapiens 36-40 34432333-2 2022 Our aim was to analyze the serum levels of tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-6, and IL-18 in chronic methamphetamine users. Methamphetamine 125-140 interleukin 6 Homo sapiens 84-102 34432333-7 2022 RESULTS: Serum levels of TNF-alpha, IL-6, and IL-18 were significantly increased in methamphetamine users who did not continue methamphetamine exposure since hospital admission (average days since last methamphetamine use = 39.06 +- 7.48) when compared to those in controls. Methamphetamine 84-99 interleukin 6 Homo sapiens 36-40 34432333-7 2022 RESULTS: Serum levels of TNF-alpha, IL-6, and IL-18 were significantly increased in methamphetamine users who did not continue methamphetamine exposure since hospital admission (average days since last methamphetamine use = 39.06 +- 7.48) when compared to those in controls. Methamphetamine 202-217 interleukin 6 Homo sapiens 36-40 34432333-8 2022 Serum IL-6 levels showed significant positive associations with BDI score and current frequency of methamphetamine use in chronic methamphetamine users. Methamphetamine 99-114 interleukin 6 Homo sapiens 6-10 34432333-8 2022 Serum IL-6 levels showed significant positive associations with BDI score and current frequency of methamphetamine use in chronic methamphetamine users. Methamphetamine 130-145 interleukin 6 Homo sapiens 6-10 34432333-9 2022 CONCLUSIONS: Our results suggest that increased TNF-alpha, IL-6, and IL-18 levels may have an important role in chronic methamphetamine use-associated psychopathological symptoms. Methamphetamine 120-135 interleukin 6 Homo sapiens 59-63 34865992-0 2022 Protective effects of progesterone on pulmonary artery smooth muscle cells stimulated with Interleukin 6 via blocking the shuttling and transcriptional function of STAT3. Progesterone 22-34 interleukin 6 Homo sapiens 91-104 34865992-11 2022 Alternatively, progesterone slightly decreased the phosphorylation of pro-proliferative Erk1/2 and Akt kinases and upregulated the anti-proliferative pSmad1-Id1/2 axis in IL-6-incubated PASMCs. Progesterone 15-27 interleukin 6 Homo sapiens 171-175 34865992-12 2022 CONCLUSIONS: Progesterone played a protective role on PASMCs in the context of IL-6, by blocking the functions of STAT3. Progesterone 13-25 interleukin 6 Homo sapiens 79-83 34838662-8 2022 Long time to return of spontaneous circulation and high lactate level at admission were associated with increased complement activation (TCC and C3bc), pro-inflammatory cytokines (IL-6, IL-8) and endothelial injury (syndecan-1) at admission. Lactic Acid 56-63 interleukin 6 Homo sapiens 180-184 34774714-6 2022 Chronic morphine treatments for 7 days reduced the protein expression of MKP-1 and MKP-3 in the spinal cord and increased the phosphorylation of p38, ERK1/2 and the level of proinflammatory mediator, such as IL-1beta, IL-6 and TNF-alpha. Morphine 8-16 interleukin 6 Homo sapiens 218-222 34170488-4 2022 We aimed to study the effect of RGZ onto inflammation-induced secretion of CXCL10, IFNgamma, TNFalpha, interleukin (IL)-6 and IL-8 by human CD4 + T and DCs, and onto IFNgamma/TNFalpha-dependent signaling in human cardiomyocytes associated with chemokine release. Rosiglitazone 32-35 interleukin 6 Homo sapiens 103-121 34170488-8 2022 In human cardiomyocytes, RGZ impaired IFNgamma/TNFalpha signal transduction, blocking the phosphorylation/nuclear translocation of signal transducer and activator of transcription 1 (Stat1) and nuclear factor-kB (NF-kB), in association with a significant decrease in CXCL10 expression, IL-6 and IL-8 release. Rosiglitazone 25-28 interleukin 6 Homo sapiens 286-290 34932406-6 2022 Our data shows a significant (p<0.05) increase in glucose levels, apoptotic markers, monocyte infiltration at the site of apoptosis and triggered inflammatory immune response (TNF-alpha and IL-6), in DOX+STZ animals compared to control and experimental groups. Doxorubicin 200-203 interleukin 6 Homo sapiens 190-194 34936178-9 2021 CONCLUSION: The RCTs examined suggest that prophylactic administration of corticosteroid agents and NAC can reduce the severity of pancreatitis as indicated by histopathologic markers, serum amylase and IL-6 levels. Acetylcysteine 100-103 interleukin 6 Homo sapiens 203-207 34932406-6 2022 Our data shows a significant (p<0.05) increase in glucose levels, apoptotic markers, monocyte infiltration at the site of apoptosis and triggered inflammatory immune response (TNF-alpha and IL-6), in DOX+STZ animals compared to control and experimental groups. Streptozocin 204-207 interleukin 6 Homo sapiens 190-194 34936813-8 2022 mTOR inhibitor rapamycin significantly suppressed the elevation of IL-6, IL-8, and VEGF stimulated by 7-KC. Sirolimus 15-24 interleukin 6 Homo sapiens 67-71 34932168-6 2021 For the optimal combination of the metal-metal junction and Raman tags, a linear relationship between the Raman signal and the concentration of IL-6 is obtained in the range 0-1000 pg mL-1with LOD of 25.2 pg mL-1and RSD < 10%. Metals 35-40 interleukin 6 Homo sapiens 144-148 34955648-16 2021 Co- and Ni-stimulated IL-6 secretion is inhibited by DEX. Dexamethasone 53-56 interleukin 6 Homo sapiens 22-26 34955648-0 2021 Metal-Stimulated Interleukin-6 Production Through a Proton-Sensing Receptor, Ovarian Cancer G Protein-Coupled Receptor 1, in Human Bronchial Smooth Muscle Cells: A Response Inhibited by Dexamethasone. Metals 0-5 interleukin 6 Homo sapiens 17-30 34981062-4 2021 The in vivo efficacy of vandetanib was assessed in a mouse model of SARS-CoV-2 infection and statistically significantly reduced the levels of IL-6, IL-10, TNF-alpha, and mitigated inflammatory cell infiltrates in the lungs of infected animals but did not reduce viral load. vandetanib 24-34 interleukin 6 Homo sapiens 143-147 34930286-8 2021 Besides, the Lipo-RSV could scavenge ROS and inhibit the NF-kappaB signal and inflammasomes, thereby reducing the pro-inflammatory cytokines IL-1beta, IL-6, and TNF-alpha. ros 37-40 interleukin 6 Homo sapiens 151-155 34955648-0 2021 Metal-Stimulated Interleukin-6 Production Through a Proton-Sensing Receptor, Ovarian Cancer G Protein-Coupled Receptor 1, in Human Bronchial Smooth Muscle Cells: A Response Inhibited by Dexamethasone. Dexamethasone 186-199 interleukin 6 Homo sapiens 17-30 34984290-0 2021 Modifications of IL-6 by Hypochlorous Acids: Effects on Receptor Binding. Hypochlorous Acid 25-43 interleukin 6 Homo sapiens 17-21 34955648-13 2021 DEX inhibited Co- and Ni-stimulated IL-6 secretion by human BSMCs as well as pH 6.3-stimulated IL-6 secretion in a dose-dependent manner. Dexamethasone 0-3 interleukin 6 Homo sapiens 36-40 34955648-13 2021 DEX inhibited Co- and Ni-stimulated IL-6 secretion by human BSMCs as well as pH 6.3-stimulated IL-6 secretion in a dose-dependent manner. Dexamethasone 0-3 interleukin 6 Homo sapiens 95-99 34943253-8 2021 Exposure to low doses of CAP enhanced the proliferation rate of cells and stimulated the expression of key genes (KGF, MMP2, GMCSF, IL-6, and IL-8) in fibroblasts, indicating the activation and initiation of the skin repair process. cap 25-28 interleukin 6 Homo sapiens 132-136 34908254-8 2021 Hyperglycemia also increases serum Nitric Oxide (NO), which decreases neutrophil motility and reduces the synthesis and release of various inflammatory mediators such as TNF-alpha and IL-1beta, IL-6. Nitric Oxide 35-47 interleukin 6 Homo sapiens 194-198 34984290-3 2021 We exposed IL-6 to hypochlorous acid (HOCl) in vitro at concentrations reported to develop in vivo. Hypochlorous Acid 19-36 interleukin 6 Homo sapiens 11-15 34984290-3 2021 We exposed IL-6 to hypochlorous acid (HOCl) in vitro at concentrations reported to develop in vivo. Hypochlorous Acid 38-42 interleukin 6 Homo sapiens 11-15 34944517-3 2021 Paradoxically, PGE2 suppresses interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) production and triggers the production of lipoxin A4 (LXA4) from AA to initiate inflammation resolution process and augment regeneration of tissues. Dinoprostone 15-19 interleukin 6 Homo sapiens 31-44 34984290-4 2021 After HOCl treatment, binding of IL-6 to IL-6R was reduced in a dose-dependent manner using a bioassay with human cells engineered to provide a luminescence response to signal transduction upon receptor activation. Hypochlorous Acid 6-10 interleukin 6 Homo sapiens 33-37 34944517-3 2021 Paradoxically, PGE2 suppresses interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) production and triggers the production of lipoxin A4 (LXA4) from AA to initiate inflammation resolution process and augment regeneration of tissues. Dinoprostone 15-19 interleukin 6 Homo sapiens 46-50 34984290-6 2021 SDS-PAGE analysis of HOCl-treated IL-6 showed little to no fragmentation or aggregation up to 1.75 mM HOCl, suggesting that the modifications induced at concentrations below 1.75 mM took place on the intact protein. Sodium Dodecyl Sulfate 0-3 interleukin 6 Homo sapiens 34-38 34984290-6 2021 SDS-PAGE analysis of HOCl-treated IL-6 showed little to no fragmentation or aggregation up to 1.75 mM HOCl, suggesting that the modifications induced at concentrations below 1.75 mM took place on the intact protein. Hypochlorous Acid 21-25 interleukin 6 Homo sapiens 34-38 34984290-9 2021 Further studies on how HOCl and HOBr and their halogenated amine derivatives interact with IL-6 and related cytokines in vivo may open up alternative therapeutic interventions with these compounds in COVID-19 and other hyperinflammatory diseases. Hypochlorous Acid 23-27 interleukin 6 Homo sapiens 91-95 34966295-6 2021 Another common denominator in the pathogenesis of insulin resistance, hypertension, and salt sensitivity (SS) is immune activation involving pro-inflammatory cytokines like tumor necrosis factor (TNF)-alpha, IL-1beta, and IL-6. Salts 88-92 interleukin 6 Homo sapiens 222-226 34944023-6 2021 Further molecular analysis revealed this process to be based on two signaling pathways: Smyd1 increased the activity of NF-kappaB and promoted the trimethylation of lysine-4 of histone-3 (H3K4me3) within the IL-6 promoter, as shown by ChIP-RT-qPCR combined with IL-6-promoter-driven luciferase reporter gene assays. Lysine 165-171 interleukin 6 Homo sapiens 208-212 34944023-6 2021 Further molecular analysis revealed this process to be based on two signaling pathways: Smyd1 increased the activity of NF-kappaB and promoted the trimethylation of lysine-4 of histone-3 (H3K4me3) within the IL-6 promoter, as shown by ChIP-RT-qPCR combined with IL-6-promoter-driven luciferase reporter gene assays. Lysine 165-171 interleukin 6 Homo sapiens 262-266 34960751-10 2021 Iron levels negatively correlated with IL-6 and higher levels of this cytokine were associated with a worse prognosis. Iron 0-4 interleukin 6 Homo sapiens 39-43 34947912-4 2021 The objective of the study was to determine the level of vitamin D ingested in a sample of patients with MS in the Valencian region (Spain), to establish the vitamin sources, and the possible link between the intake of vitamin D and the pathogenesis of the disease through a relationship with the level of IL-6. Vitamin D 219-228 interleukin 6 Homo sapiens 306-310 34947912-8 2021 (3) Results: The results show a low intake of vitamin D, which is significantly and negatively related to the intake of proteins of vegetable origin, which are consumed in less quantity than proteins of animal origin, and significantly and negatively related with the high blood levels of IL-6, possibly as a consequence of the high intake of fats, mainly unsaturated. Vitamin D 46-55 interleukin 6 Homo sapiens 289-293 34947912-9 2021 (4) Conclusions: MS patients in the Valencian region ingest little vitamin D related to low intake of vegetable protein, which would explain the high levels of IL-6 linked to the high intake of mainly saturated fats. Vitamin D 67-76 interleukin 6 Homo sapiens 160-164 34944509-11 2021 High doses of vitamin D supplementation led to a significant decrease in pro-inflammatory cytokines (IFN- , TNF-alpha, IL-1beta, IL-6, IL-8, and IL-17) and high-sensitivity C-reactive protein (hsCRP), whereas the production of anti-inflammatory cytokines (IL-10, IL-5) was up-regulated. Vitamin D 14-23 interleukin 6 Homo sapiens 129-133 34947912-3 2021 These IL-6 levels could be lowered with an adequate dietary intake of vitamin D. Vitamin D 70-79 interleukin 6 Homo sapiens 6-10 34947912-4 2021 The objective of the study was to determine the level of vitamin D ingested in a sample of patients with MS in the Valencian region (Spain), to establish the vitamin sources, and the possible link between the intake of vitamin D and the pathogenesis of the disease through a relationship with the level of IL-6. Vitamin D 57-66 interleukin 6 Homo sapiens 306-310 34859370-7 2022 RESULTS: Our results demonstrated that resveratrol significantly reduced cell proliferation and enhanced chemosensitivity in breast cancer cells by inhibiting production of IL-6 and STAT3 activation. Resveratrol 39-50 interleukin 6 Homo sapiens 173-177 34693451-5 2021 However, gefitinib treatment results in the feedback activation of signal transducer and activator of transcription 3 (STAT3) induced by interleukin 6 (IL-6) secretion. Gefitinib 9-18 interleukin 6 Homo sapiens 137-150 34693451-5 2021 However, gefitinib treatment results in the feedback activation of signal transducer and activator of transcription 3 (STAT3) induced by interleukin 6 (IL-6) secretion. Gefitinib 9-18 interleukin 6 Homo sapiens 152-156 34693451-7 2021 Western blot analysis demonstrates that stattic treatment in gefitinib-treated OS abrogates the IL-6-induced STAT3 activation and subsequently further restrains the activities of EGFR, Akt, and ERK pathways in tumor cells. Gefitinib 61-70 interleukin 6 Homo sapiens 96-100 34693451-8 2021 This study confirms that the EGFR inhibitor of gefitinib has moderate anti-tumor effects on OS through IL-6 secretion-mediated STAT3 activation. Gefitinib 47-56 interleukin 6 Homo sapiens 103-107 34917160-8 2021 Finally, six genes, namely, CXCL1, HIF1A, IL-6, MMP3, NOX4, and PTGS2, were selected to validate the treatment effects of the resveratrol. Resveratrol 126-137 interleukin 6 Homo sapiens 42-46 34917160-10 2021 In addition, in these chondrocytes, CXCL1, HIF1A, IL-6, MMP3, NOX4, and PTGS2 were reduced considerably, but HIF1A was significantly increased after resveratrol treatment. Resveratrol 149-160 interleukin 6 Homo sapiens 50-54 34917160-11 2021 Conclusions: Our data indicates that CXCL1, HIF1A, IL-6, MMP3, NOX4, and PTGS2 are all targets of resveratrol therapy. Resveratrol 98-109 interleukin 6 Homo sapiens 51-55 34871429-9 2022 RESULTS: DHA concentration in RBC membranes was inversely associated with IL-6 (beta = -0.0066, P < 0.001); EPA was inversely associated with TNFalpha (beta = -0.4925, P < 0.001); and the NIR was inversely associated with MCP-1 (beta = -0.8345, P < 0.001) and IL-10 (beta = -1.2868, P < 0.001). dehydroacetic acid 9-12 interleukin 6 Homo sapiens 74-78 34862643-10 2021 The activities of tumor necrosis factor-alpha and interleukin-6 24 hours lowered in the LIFU group (P < .01). lifu 88-92 interleukin 6 Homo sapiens 50-63 34899944-11 2021 Conclusion: The possible mechanisms of the components of the Zhishi-Baizhu herb pair in treating gastric cancer might be related to luteolin and naringenin, which intervened with the targets AKT1, MMP9, IL-6, CCND1, BCL2, MTOR, and MDM2, and are linked with the PI3K-Akt and IL-17 signaling pathways. naringenin 145-155 interleukin 6 Homo sapiens 203-207 34943719-6 2021 Herein, we demonstrated that dexamethasone binds with high affinity to interlukin-1 (IL-1), IL-6, IL-8, IL-12, IL-21, INF2, TGFbeta-1, INF-gamma, CXCL8, some of the receptors, IL-1R, IL-21R, IFNGR, INFAR, IL-6alphaR-gp130, ST2 and the SARS-CoV-2 protein NSP macro X, and 3CLpro, forming stable drug-protein complexes. Dexamethasone 29-42 interleukin 6 Homo sapiens 92-96 34917989-8 2022 Conclusions: Cardiovascular autonomic functioning and blood glucose control were significantly associated with stressor-evoked IL-6 responses when controlling for BMI and age. Glucose 60-67 interleukin 6 Homo sapiens 127-131 34977907-9 2021 Abidol-treated patients, compared with No-Abidol-treated patients, had a shorter duration from onset of symptoms to admission, less frequent renal dysfunction, lower white blood cell counts (lymphocytes <0.8) and erythrocyte sending rate, lower interleukin-6, higher platelet counts and plasma IgG and oxygen saturation, and less frequent myocardial injury. abidol 0-6 interleukin 6 Homo sapiens 245-258 34859370-9 2022 Further, resveratrol decreased IL-6 levels in LPS-treated differentiated macrophages. Resveratrol 9-20 interleukin 6 Homo sapiens 31-35 34859370-11 2022 CONCLUSION: This study revealed that resveratrol inhibited breast cancer cell proliferation by promoting M1/M2 macrophage polarization ratio and suppressing IL-6/pSTAT3 pathway. Resveratrol 37-48 interleukin 6 Homo sapiens 157-161 34402724-0 2021 Interleukin-6 promotes ferroptosis in bronchial epithelial cells by inducing reactive oxygen species-dependent lipid peroxidation and disrupting iron homeostasis. Reactive Oxygen Species 77-100 interleukin 6 Homo sapiens 0-13 34658261-7 2021 Notably, MAZ51 caused significant upregulation of intrarenal phospho-NF-kB, phospho-JNK, and IL-6. MAZ51 9-14 interleukin 6 Homo sapiens 93-97 34402724-0 2021 Interleukin-6 promotes ferroptosis in bronchial epithelial cells by inducing reactive oxygen species-dependent lipid peroxidation and disrupting iron homeostasis. Iron 145-149 interleukin 6 Homo sapiens 0-13 34402375-6 2021 Firstly, we found that Tamsulosin reduced high glucose-induced expressions of TNF-alpha, IL-6, and IL-8. Glucose 47-54 interleukin 6 Homo sapiens 89-93 34402724-10 2021 We found that IL-6 decreased the activity, promoted lipid peroxidation, disrupted iron homeostasis of BEAS-2B cells, and induced iron death in bronchial epithelial BEAS-2B cells. Iron 82-86 interleukin 6 Homo sapiens 14-18 34402724-12 2021 Overall, IL-6 promotes ferroptosis in bronchial epithelial cells by inducing reactive oxygen species (ROS)-dependent lipid peroxidation and disrupting iron homeostasis. Reactive Oxygen Species 77-100 interleukin 6 Homo sapiens 9-13 34402724-12 2021 Overall, IL-6 promotes ferroptosis in bronchial epithelial cells by inducing reactive oxygen species (ROS)-dependent lipid peroxidation and disrupting iron homeostasis. Reactive Oxygen Species 102-105 interleukin 6 Homo sapiens 9-13 34402724-12 2021 Overall, IL-6 promotes ferroptosis in bronchial epithelial cells by inducing reactive oxygen species (ROS)-dependent lipid peroxidation and disrupting iron homeostasis. Iron 151-155 interleukin 6 Homo sapiens 9-13 34414854-10 2021 Transfection of p-LUCAT1 significantly reversed the decreased SOD levels, the increased MDA and ROS content, and the elevated tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1beta) in H2O2-stimulated cells (P < 0.001). Hydrogen Peroxide 226-230 interleukin 6 Homo sapiens 167-180 34414854-10 2021 Transfection of p-LUCAT1 significantly reversed the decreased SOD levels, the increased MDA and ROS content, and the elevated tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1beta) in H2O2-stimulated cells (P < 0.001). Hydrogen Peroxide 226-230 interleukin 6 Homo sapiens 182-186 34308659-5 2021 Methyl mercury treatment significantly induced the adhesion of monocyte to HMEC-1 endothelial cells, a critical step in atherosclerosis, while also upregulating the expression of proinflammatory cytokines interleukin-6, interleukin-8. methyl mercury 0-14 interleukin 6 Homo sapiens 205-218 34857394-7 2021 Folic acid supplementation significantly reduced serum levels of C-reactive protein (mean difference (MD), -0.21 mg/L; 95% CI, -0.41 to -0.01; n = 16), TNF-alpha (MD, -14.88 pg/mL; 95% CI, -23.68 to -6.09; n = 10), and IL-6 (MD, -0.93 pg/mL; 95% CI, -1.72 to -0.14; n = 11). Folic Acid 0-10 interleukin 6 Homo sapiens 219-223 34857198-5 2021 Novel findings of Vitamin D suggest that along with regulation of cell growth, neuroprotective and mood-stabilizing effects, it regulates the immune response also modulate cytokine Interleukin-6 (IL-6) by inducing progesterone-induced blocking factor (PIBF), given the IL-6 levels are considerably high in COVID-19 patients which increases the further complications. Vitamin D 18-27 interleukin 6 Homo sapiens 181-194 34857198-5 2021 Novel findings of Vitamin D suggest that along with regulation of cell growth, neuroprotective and mood-stabilizing effects, it regulates the immune response also modulate cytokine Interleukin-6 (IL-6) by inducing progesterone-induced blocking factor (PIBF), given the IL-6 levels are considerably high in COVID-19 patients which increases the further complications. Vitamin D 18-27 interleukin 6 Homo sapiens 196-200 34857198-5 2021 Novel findings of Vitamin D suggest that along with regulation of cell growth, neuroprotective and mood-stabilizing effects, it regulates the immune response also modulate cytokine Interleukin-6 (IL-6) by inducing progesterone-induced blocking factor (PIBF), given the IL-6 levels are considerably high in COVID-19 patients which increases the further complications. Vitamin D 18-27 interleukin 6 Homo sapiens 269-273 34453520-6 2021 Poly(I:C) dramatically induced the expression of the pro-inflammatory cytokines TNF-alpha and IL-6 in SC and LC through Toll-like receptor 3 and IFN-beta promoter stimulator 1 signaling pathways, impairing the integrity of the blood-testis barrier and testosterone synthesis. Testosterone 252-264 interleukin 6 Homo sapiens 94-98 34547383-12 2021 Meanwhile, DOX further increased the elevation of plasma IL-6, IL-1beta and TNF-alpha induced by DMM and obviously reduced the expression of chondrocyte differentiation-related markers, including collagen type II a1 (Col2A1), collagen type X alpha 1 (Col10A1), and aggrecan. Doxorubicin 11-14 interleukin 6 Homo sapiens 57-61 34725715-10 2021 Isoprenaline-mediated IL-6 secretion was attenuated by dasatinib, a Src inhibitor, and PD98059, an ERK1/2 inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 87-94 interleukin 6 Homo sapiens 22-26 34700113-6 2021 Here, we found that clevudine is capable of suppressing pro-fibrotic phenotype (i.e., CD206, Arg1 and YM1) of M2 macrophages while enhancing anti-fibrotic phenotype (i.e., CD86, IL-6 and IL-10) by inhibiting PI3K/Akt signaling pathway. clevudine 20-29 interleukin 6 Homo sapiens 178-182 34547109-8 2021 Moreover, in MS patients, significant correlations were found between L-Glu and both CSF levels of lactate and the inflammatory molecules interleukin (IL)-2, IL-6, and IL-1 receptor antagonist. Lactic Acid 99-106 interleukin 6 Homo sapiens 158-162 34547109-8 2021 Moreover, in MS patients, significant correlations were found between L-Glu and both CSF levels of lactate and the inflammatory molecules interleukin (IL)-2, IL-6, and IL-1 receptor antagonist. Glutamic Acid 70-75 interleukin 6 Homo sapiens 158-162 34534743-5 2021 Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot confirmed that gossypol downregulated CX43, nuclear factor-kappa B (NF-kappaB) p65, TNF-alpha, toll like receptor 4 (TLR4), myeloid differentiation primary response gene 88 (MyD88) and interleukin-6 (IL-6) expressions. Gossypol 91-99 interleukin 6 Homo sapiens 261-274 34559375-17 2021 Higher saliva cortisol levels, serum cortisol, glucose, C-reactive protein and interleukin-6 were detected after PEG placement, confirming considerable stress response. Polyethylene Glycols 113-116 interleukin 6 Homo sapiens 79-92 34534743-5 2021 Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot confirmed that gossypol downregulated CX43, nuclear factor-kappa B (NF-kappaB) p65, TNF-alpha, toll like receptor 4 (TLR4), myeloid differentiation primary response gene 88 (MyD88) and interleukin-6 (IL-6) expressions. Gossypol 91-99 interleukin 6 Homo sapiens 276-280 34826187-9 2022 Taken together, these observations suggest that SIRT1 stabilized through phosphorylation on serine 27 exerts oncogenic effects at least partly through deacetylation-dependent activation of Snail and subsequent transcription of IL-6 and IL-8 in human colon cancer cells. Serine 92-98 interleukin 6 Homo sapiens 227-231 34868528-12 2021 In the oxygen-glucose-deprived reoxygenation model group, SNHG15 expression increased, miR-141 expression decreased, SIRT1 expression increased, and the expressions of p65, TNF-alpha, ROS, iNOS, and IL-6 decreased. Oxygen 7-13 interleukin 6 Homo sapiens 199-203 34868528-12 2021 In the oxygen-glucose-deprived reoxygenation model group, SNHG15 expression increased, miR-141 expression decreased, SIRT1 expression increased, and the expressions of p65, TNF-alpha, ROS, iNOS, and IL-6 decreased. Glucose 14-21 interleukin 6 Homo sapiens 199-203 34868528-13 2021 In the SNHG15-siRNA-transfected oxygen-glucose-deprived reoxygenation cell model group, miR-141 expression increased, SIRT1 expression decreased, and the expressions of p65, TNF-alpha, and IL-6 increased compared with the si-NC group. Oxygen 32-38 interleukin 6 Homo sapiens 189-193 34899767-0 2021 Retraction: Curcumin Blunts IL-6 Dependent Endothelial-to-Mesenchymal Transition to Alleviate Renal Allograft Fibrosis Through Autophagy Activation. Curcumin 12-20 interleukin 6 Homo sapiens 28-32 34946023-7 2021 Our results showed that insulin-mediated reduction of UPEC infection in a high-glucose environment was not only due to the downregulation of JAK1/2 and phosphorylated STAT-1/3, but also because of the decreased expression of TLR-4 proteins and pro-inflammatory IL-6. Glucose 79-86 interleukin 6 Homo sapiens 261-265 34303983-5 2021 Cd exposure also elicited overexpression of GFAP, a marker of astrocytes and resulted in IL-6 release. Cadmium 0-2 interleukin 6 Homo sapiens 89-93 34933727-9 2021 Other pivotal features of melatonin are its anti-inflammatory properties, which decrease pro-inflammatory cytokines expression and factors such as IL-8, IL-6, and TNF. Melatonin 26-35 interleukin 6 Homo sapiens 153-157 34881181-0 2021 Metformin Downregulates PD-L1 Expression in Esophageal Squamous Cell Catrcinoma by Inhibiting IL-6 Signaling Pathway. Metformin 0-9 interleukin 6 Homo sapiens 94-98 34885656-5 2021 In our previous work, we demonstrated that LPE can reduce IL-6-induced migration/invasiveness and MMP-9/2 up-regulation in some gastric cancer cell lines. LPC-ETHER 43-46 interleukin 6 Homo sapiens 58-62 34831450-10 2021 Furthermore, histone acetylation inhibition by anacardic acid or curcumin reduces IL-6 production. Curcumin 65-73 interleukin 6 Homo sapiens 82-86 34881181-7 2021 PD-L1 expression in ESCC cell lines was significantly inhibited by metformin via the IL-6/JAK2/STAT3 signaling pathway but was not correlated with the canonical AMPK pathway. Metformin 67-76 interleukin 6 Homo sapiens 85-89 34881181-10 2021 Conclusions: Metformin downregulated PD-L1 expression by blocking the IL-6/JAK2/STAT3 signaling pathway in ESCC, which enhanced the antitumor immune response. Metformin 13-22 interleukin 6 Homo sapiens 70-74 34867400-6 2021 Furthermore, using an approved clinical durgs library, we found two clinical drugs, Cepharanthine and Glucosamine, significantly inhibited ACE2 level, IFNbeta level, and NF-kappaB signaling downstream TNFalpha and IL6 levels. cepharanthine 84-97 interleukin 6 Homo sapiens 214-217 34833991-12 2021 Finally, the pro-inflammatory cytokines (IL-1beta, IL-6, and IL-8) released by PBMCs triggered by SARS-CoV-2 were decreased after treatment with curcumin. Curcumin 145-153 interleukin 6 Homo sapiens 51-55 34869555-13 2021 Conclusion: Preoperative CHO and drinking water are associated with decreased levels of IL-6, IL-8, and TNF. Water 42-47 interleukin 6 Homo sapiens 88-92 34831435-2 2021 Our previous studies demonstrated that resveratrol (RV), a nutraceutical and caloric restriction mimetic with tumor-suppressive properties, counteracts cancer cell motility induced by stromal IL-6 by upregulating autophagy. Resveratrol 39-50 interleukin 6 Homo sapiens 192-196 34831435-2 2021 Our previous studies demonstrated that resveratrol (RV), a nutraceutical and caloric restriction mimetic with tumor-suppressive properties, counteracts cancer cell motility induced by stromal IL-6 by upregulating autophagy. Resveratrol 52-54 interleukin 6 Homo sapiens 192-196 34198336-0 2021 The IL6/sIL-6Ralpha trans-signaling increases PGE2 production in human granulosa cells. Dinoprostone 46-50 interleukin 6 Homo sapiens 4-7 34198336-3 2021 In the present study, primary and immortalized (SVOG) human granulosa-lutein (hGL) cells were used to investigate the effects of IL6 on the expression of prostaglandin-endoperoxide synthase 2 (PTGS2) and the subsequent synthesis of prostaglandin E2 (PGE2) and to investigate the underlying molecular mechanisms. Dinoprostone 232-248 interleukin 6 Homo sapiens 129-132 34198336-3 2021 In the present study, primary and immortalized (SVOG) human granulosa-lutein (hGL) cells were used to investigate the effects of IL6 on the expression of prostaglandin-endoperoxide synthase 2 (PTGS2) and the subsequent synthesis of prostaglandin E2 (PGE2) and to investigate the underlying molecular mechanisms. Dinoprostone 250-254 interleukin 6 Homo sapiens 129-132 34198336-4 2021 We found that instead of classic signaling, IL6/sIL-6Ralpha trans-signaling induced the expression of PTGS2 and production of PGE2 in both SVOG cells and primary hGL cells. Dinoprostone 126-130 interleukin 6 Homo sapiens 44-47 34198336-7 2021 Additionally, suppressor of cytokine signaling 3 (SOCS3) acts as a negative-feedback regulator in IL6/sIL-6Ralpha-induced cellular activities, including the activation and nuclear translocation of STAT3, upregulation of PTGS2 expression, and increase in PGE2 production in SVOG cells. Dinoprostone 254-258 interleukin 6 Homo sapiens 98-101 34198336-8 2021 In conclusion, IL6 trans-signaling upregulates the expression of PTGS2 and increases the production of PGE2 via the JAK2/STAT3/SOCS3 signaling pathway in hGL cells. Dinoprostone 103-107 interleukin 6 Homo sapiens 15-18 34757578-9 2022 Meanwhile, the most effective corticosteroid, interleukin-6 antagonist, and Janus kinase (JAK) inhibitor were hydrocortisone, sarilumab, and ruxolitinib, respectively. Hydrocortisone 110-124 interleukin 6 Homo sapiens 46-59 34867348-8 2021 Targeted protein kinase A (PKA) and Exchange Protein Activated by cAMP (EPAC) activation regulated IL-6 and IL-1beta expression, albeit in different ways, but both cytokines were effectively decreased with RG0216. Cyclic AMP 66-70 interleukin 6 Homo sapiens 99-103 34867348-7 2021 We showed that LPS-induced expression of IL-6 and IL-1beta was cAMP dependent, that IL-6 and IL-1beta expression were induced by direct cAMP activation (forskolin) and that RG0216 and deprenyl effectively reduced cAMP-mediated cytokine expression. Cyclic AMP 63-67 interleukin 6 Homo sapiens 41-45 34867348-7 2021 We showed that LPS-induced expression of IL-6 and IL-1beta was cAMP dependent, that IL-6 and IL-1beta expression were induced by direct cAMP activation (forskolin) and that RG0216 and deprenyl effectively reduced cAMP-mediated cytokine expression. Cyclic AMP 136-140 interleukin 6 Homo sapiens 41-45 34867348-7 2021 We showed that LPS-induced expression of IL-6 and IL-1beta was cAMP dependent, that IL-6 and IL-1beta expression were induced by direct cAMP activation (forskolin) and that RG0216 and deprenyl effectively reduced cAMP-mediated cytokine expression. Cyclic AMP 136-140 interleukin 6 Homo sapiens 84-88 34509913-5 2021 In parallel, HFO attenuated the expression of IL-1beta, IL-6 and TNF-alpha. 1,3,3,3-tetrafluoropropene 13-16 interleukin 6 Homo sapiens 56-60 34769415-6 2021 In addition, pretreatment with naringenin might inhibit the secretion of TNF-alpha, IL-6, and IL-8, as well as the proteins cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) via the suppression of NF-kappaB and mitogen-activated protein kinase (MAPK) signaling in ethanol-stimulated stomach epithelial KATO III cells. naringenin 31-41 interleukin 6 Homo sapiens 84-88 34749366-13 2021 miR-381-3p overexpression inhibited the release of IL-6, IL-1beta, and TNF-alpha induced by Abeta25-35 treatment, whereas miR-381-3p downregulation further promoted the release of inflammatory cytokines. mir-381-3p 0-10 interleukin 6 Homo sapiens 51-55 34909296-1 2021 Background and objective This study aimed to investigate how different doses of progesterone influence the concentrations of interleukin-6 (IL-6) and tumor necrotizing factor-alpha (TNF-alpha), which are proinflammatory cytokines, as well as that of IL-10, which is an anti-inflammatory cytokine, in pregnant women with threatened abortion. Progesterone 80-92 interleukin 6 Homo sapiens 125-138 34909296-1 2021 Background and objective This study aimed to investigate how different doses of progesterone influence the concentrations of interleukin-6 (IL-6) and tumor necrotizing factor-alpha (TNF-alpha), which are proinflammatory cytokines, as well as that of IL-10, which is an anti-inflammatory cytokine, in pregnant women with threatened abortion. Progesterone 80-92 interleukin 6 Homo sapiens 140-144 34909296-11 2021 Conclusion Progesterone used to treat imminent abortion reduces the levels of proinflammatory cytokines, such as IL-6 and TNF-alpha, while increasing those of anti-inflammatory cytokine IL-10 in proportion to the dose administered. Progesterone 11-23 interleukin 6 Homo sapiens 113-117 34769415-6 2021 In addition, pretreatment with naringenin might inhibit the secretion of TNF-alpha, IL-6, and IL-8, as well as the proteins cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) via the suppression of NF-kappaB and mitogen-activated protein kinase (MAPK) signaling in ethanol-stimulated stomach epithelial KATO III cells. Ethanol 282-289 interleukin 6 Homo sapiens 84-88 34738553-5 2021 In adults with COVID-19, an inverse association between sodium and interleukin-6 levels has been found, indicating that hyponatraemia could be used as a surrogate marker for the risk of cytokine storm and may facilitate the identification of patients who could benefit from immunomodulatory agents. Sodium 56-62 interleukin 6 Homo sapiens 67-80 34523725-5 2021 For this secondary data analysis, we proposed a conceptual model linking alcohol consumption, the pro-inflammatory cytokine IL-6, brain structure and NfL in heavy-drinking participants. Alcohols 73-80 interleukin 6 Homo sapiens 124-128 34585422-9 2021 In contrast, EtOH"s inhibition of SAA1-induced inflammatory cytokines (IL-6, IFN-gamma) and reactive oxygen species (ROS) was Notch-independent, as these effects were unaffected by DAPT or by N1 and/or N4 knockdown. Ethanol 13-17 interleukin 6 Homo sapiens 71-75 34872261-0 2021 All-trans retinoic acid inhibits epithelial-to-mesenchymal transition (EMT) through the down-regulation of IL-6 in endometriosis. Tretinoin 3-23 interleukin 6 Homo sapiens 107-111 34872261-10 2021 After ATRA treatment, the expression of IL-6 was significantly reduced, accompanied by a decrease in the migration, invasion, and EMT of large endometriotic stromal CFUs. Tretinoin 6-10 interleukin 6 Homo sapiens 40-44 34872261-11 2021 In addition, the inhibition of ATRA was mediated by IL-6. Tretinoin 31-35 interleukin 6 Homo sapiens 52-56 34872261-13 2021 ATRA may be a promising therapeutic strategy aimed at IL-6 for the stem-cell treatment of EMs. Tretinoin 0-4 interleukin 6 Homo sapiens 54-58 34390807-4 2021 The two mutants displayed elevated levels of tyrosine phosphorylation, premature nuclear accumulation, and differential transcriptional responses following stimulation of cells with interleukin-6 and interferon-gamma. Tyrosine 45-53 interleukin 6 Homo sapiens 182-195 34329054-12 2021 We also observed that exposure to metal constituents in the highly polluted region is correlated with increased TNF-alpha and IL-6 with 131.80% (95% CI: 56.01, 244.39) and 47.51% (95% CI: 33.01, 62.05) per IQR of Hg, respectively. Metals 34-39 interleukin 6 Homo sapiens 126-130 34607979-6 2021 Accordingly, the p27 and p21 promoter activities were enhanced while Bcl-2 and IL-6 activities were significantly reduced by metformin treatment. Metformin 125-134 interleukin 6 Homo sapiens 79-83 34400170-4 2021 A growing number of studies have demonstrated that lactic acid regulates the degradation of collagen IV, collagen VII, and glycoprotein; the synthesis of collagen I; and multiple signaling pathways, including TGF-beta/Smad, Wnt/beta-catenin, IL-6/STAT3, and HGF/MET, which are associated with basement membrane (BM) remodeling and epithelial-mesenchymal transition (EMT), two hallmarks of the tumor invasive process. Lactic Acid 51-62 interleukin 6 Homo sapiens 242-246 34462267-9 2021 IL-6/STAT3 initiated CTH expression and activity, and the effect on the resistant phenotype was exclusively dependent on CTH and ROS. Reactive Oxygen Species 129-132 interleukin 6 Homo sapiens 0-4 34342052-5 2021 Time-course studies with complete blood counts, biochemical markers, cytokines, and cortisol showed transient increases in neutrophils, monocytes, myoglobin, high-sensitivity C-reactive protein (hsCRP), G-CSF, IL-6, and cortisol. Hydrocortisone 84-92 interleukin 6 Homo sapiens 210-214 34329054-10 2021 In TBZ, an increased IQR of PM2.5 mass during 0-5 days was -correlated with a significant rise in diastolic blood pressure, heart rate, TNF-alpha, FENO, and NOx and reduction of IL-6. tbz 3-6 interleukin 6 Homo sapiens 178-182 34630655-7 2021 The present study revealed that among the isoflavone derivatives examined (daidzein, genistein and glycitein), daidzein inhibited the production of IL-6, but not IL-8, by IL-1beta-stimulated synovial MH7A cells via the suppression of NF-kappaB p65 and ERK1/2 activation. Isoflavones 42-52 interleukin 6 Homo sapiens 148-152 34342052-7 2021 Correlations were observed between the neutrophil count and G-CSF, IL-6, and cortisol (G-CSF; r = 0.667, IL-6; r = 0.667, cortisol; r = 0.623). Hydrocortisone 77-85 interleukin 6 Homo sapiens 105-109 34342052-8 2021 CONCLUSION: These results suggest that G-CSF is directly involved, and IL-6 is involved via cortisol in the transient neutrophilia that occurs after marathon races. Hydrocortisone 92-100 interleukin 6 Homo sapiens 71-75 34630655-7 2021 The present study revealed that among the isoflavone derivatives examined (daidzein, genistein and glycitein), daidzein inhibited the production of IL-6, but not IL-8, by IL-1beta-stimulated synovial MH7A cells via the suppression of NF-kappaB p65 and ERK1/2 activation. glycitein 99-108 interleukin 6 Homo sapiens 148-152 34630663-9 2021 The levels of TC, FC and CE and the mRNA levels of IL-1beta, IL-6, and TNF-alpha in the matrine group were lower than those in the model group, but higher than those in the normal group. matrine 88-95 interleukin 6 Homo sapiens 61-65 34757278-8 2021 Also, at both time points of before and after plasmapheresis, serum levels of IL-1, IL-6, IFN-gamma and IL-17 were inversely correlated to blood oxygen saturation. Oxygen 145-151 interleukin 6 Homo sapiens 84-88 34438042-2 2021 Here we demonstrate that the hydrophobic bile acid, deoxycholic acid (DCA), stimulated the production of IL-6 and IL-8 mRNA and protein in Het-1A, a model of normal oesophageal cells. Bile Acids and Salts 41-50 interleukin 6 Homo sapiens 105-109 34438042-4 2021 The cholesterol-interacting agent, nystatin, which binds cholesterol without removing it from the membrane, synergized with DCA to induce IL-6 and IL-8. Cholesterol 4-15 interleukin 6 Homo sapiens 138-142 34490483-5 2021 Furthermore, Sal B significantly attenuated CHC-induced release of proinflammatory factors (TNF-alpha and IL-6) by macrophages. salvianolic acid B 13-18 interleukin 6 Homo sapiens 106-110 34563836-9 2021 Furthermore, cortisol interacted with HSV-1 and IL-6, and CRP for both cross-sectional cognitive function and rate of decline. Hydrocortisone 13-21 interleukin 6 Homo sapiens 48-52 34628106-5 2021 In human placental tissue culture, treatment with BHB suppressed the secretion levels of inflammatory cytokines, such as interleukin (IL)-1beta, IL-6, and IL-8, but did not affect the mRNA expression levels of NLRP3 inflammasome-associated factors. 3-Hydroxybutyric Acid 50-53 interleukin 6 Homo sapiens 145-149 34565256-5 2021 The results showed that LPS induced NF-kappaB-related pulmonary inflammation in observers and silicosis patients, as confirmed by an increase in the expression of IL-1beta, IL-6, TNF-alpha, and p65, which could be inhibited by 3-MA treatment. 3-methyladenine 227-231 interleukin 6 Homo sapiens 173-177 34754315-10 2021 Molecular docking results showed that quercetin, luteolin, kaempferol, tanshinone IIa, wogonin, naringenin, nobiletin, dihydrotanshinlactone, beta-sitosterol, and salviolone have good affinity with core target proteins IL6, PTGS2, MAPK1, MAPK3, and CGRP1. naringenin 96-106 interleukin 6 Homo sapiens 219-222 34148127-14 2021 GSEA revealed that epithelial-mesenchymal transition, IL-6/JAK/STAT3 signaling, the inflammatory response, and TNF-alpha signaling via the NFkappaB pathway were remarkably suppressed pathways in patients with BRAF mutations. gsea 0-4 interleukin 6 Homo sapiens 54-58 34754315-10 2021 Molecular docking results showed that quercetin, luteolin, kaempferol, tanshinone IIa, wogonin, naringenin, nobiletin, dihydrotanshinlactone, beta-sitosterol, and salviolone have good affinity with core target proteins IL6, PTGS2, MAPK1, MAPK3, and CGRP1. tanshinone 71-85 interleukin 6 Homo sapiens 219-222 34717622-1 2021 BACKGROUND: IL-6 plays a pivotal role in resistance to chemotherapeutics, including lobaplatin. lobaplatin 84-94 interleukin 6 Homo sapiens 12-16 34732304-12 2021 The inflammatory cytokines, TNF-alpha and IL-6, were significantly increased after HDAC6 knockdown in PMA-stimulated THP1 cells and SW982 cells (p < 0.05). Tetradecanoylphorbol Acetate 102-105 interleukin 6 Homo sapiens 42-46 34717622-5 2021 The cells were divided into the control group (Con), the lobaplatin group (Lob), and the rhIL-6-and-lobaplatin group (IL-6). lobaplatin 100-110 interleukin 6 Homo sapiens 118-122 34842603-5 2021 The results of this study revealed that vitamin D deficiency is associated with an increased expression of IL-33, IL-37, IL-6, TNF-alpha, TLRs, DAMPs, and MMPs, while vitamin D supplementation is associated with a decreased expression of the former. Vitamin D 40-49 interleukin 6 Homo sapiens 121-125 34374752-6 2021 Furthermore, increased TNF-alpha and IL-6 in COVID-19 plasma induced mitochondria apoptosis and caused DNA damage by elevating reactive oxygen species levels of the adult T cells. Reactive Oxygen Species 127-150 interleukin 6 Homo sapiens 37-41 34836070-13 2021 Log-IL6 was associated with UEA (p < 0.001). uea 28-31 interleukin 6 Homo sapiens 4-7 34842603-8 2021 Taken together, the results of this study suggest that modulating expression of IL-33, IL-6, TNF-alpha, TLRs, DAMPs, and MMPs with vitamin D supplementation may serve as a novel therapeutic to attenuate inflammation and cartilage degeneration in osteoarthritis. Vitamin D 131-140 interleukin 6 Homo sapiens 87-91 34760922-14 2021 A positive correlation between IL-6 or IL-17A and STAT3 and negative correlation between SOCS3 and STAT3 were shown, suggesting that the IL-6/STAT3 pathway may be involved in OVA + ozone-induced corticosteroid-resistant airway inflammation. Ozone 181-186 interleukin 6 Homo sapiens 31-35 34760922-0 2021 STAT3 and IL-6 Contribute to Corticosteroid Resistance in an OVA and Ozone-induced Asthma Model with Neutrophil Infiltration. Ozone 69-74 interleukin 6 Homo sapiens 10-14 34760922-14 2021 A positive correlation between IL-6 or IL-17A and STAT3 and negative correlation between SOCS3 and STAT3 were shown, suggesting that the IL-6/STAT3 pathway may be involved in OVA + ozone-induced corticosteroid-resistant airway inflammation. Ozone 181-186 interleukin 6 Homo sapiens 137-141 34760922-16 2021 The IL-6/STAT3 pathway may contribute to corticosteroid insensitivity in OVA + ozone-induced neutrophilic airway inflammation through regulation of Th17 cells and could provide new targets for individual treatment of corticosteroid resistance in asthma. Ozone 79-84 interleukin 6 Homo sapiens 4-8 34733901-8 2021 SCFAs can enhance the immune response by stimulating cytokine production (e.g. TNF-alpha, IL-2, IL-6, and IL-10) in the immune cells of the host. Fatty Acids, Volatile 0-5 interleukin 6 Homo sapiens 96-100 34174792-8 2021 CRP,TNF-?, IL-6 and IL-10 levels were also correlated with serum vitamin D levels (p <0.05). Vitamin D 65-74 interleukin 6 Homo sapiens 11-15 34669701-6 2021 We apply the mathematical model to a single or combination (ATV+TZB) therapy used in the experiments to demonstrate that the CSCs can enhance CRCC by secreting IL-6 and ATV may interfere the whole regulation. Atorvastatin 60-63 interleukin 6 Homo sapiens 160-164 34666750-10 2021 LABA/GCS attenuation of Poly I:C or imiquimod-induced IL-6 and IL-8 were potentiated with ABCC4 and PDE4 inhibition, which was greater when ABCC4 and PDE4 inhibition was combined. Poly I 24-30 interleukin 6 Homo sapiens 54-58 34822668-5 2021 The generation of proinflammatory cytokines, such as interleukin (IL)-1beta, IL-6, and tumour necrosis factor alpha, is induced by 1-NP in a concentration-dependent manner in macrophages. 1-nitropyrene 131-135 interleukin 6 Homo sapiens 77-81 34549226-8 2021 Interestingly, while high IL6 expression was related to poor survival in CRC (p < 0.05), IL6 methylation was associated with an increased risk of CRC, in which 25(OH)D partially mediated this association (p < 0.05). 25(oh)d 160-167 interleukin 6 Homo sapiens 89-92 34549226-9 2021 Our study suggests a potential association between epigenetic regulation of inflammatory mediators in VAT - such as IL6 - in the CRC context, in which 25(OH)D may mediate this risk. 25(oh)d 151-158 interleukin 6 Homo sapiens 116-119 34549226-10 2021 Therefore, vitamin D could affect the epigenetic status of IL6, which can be considered for additional preventive strategies. Vitamin D 11-20 interleukin 6 Homo sapiens 59-62 34733276-6 2021 Furthermore, we found significantly increased plasma levels of IL-6, IL-12, IL-17, IL-18, stem cell factor (SCF), and IL-21/IL-23 in SLE patients compared to healthy controls, and those levels positively correlated with the plasma levels of 17beta-estradiol. Estradiol 241-257 interleukin 6 Homo sapiens 63-67 34733276-8 2021 In vitro treatment of PBMCs from either SLE patients or healthy controls with 17beta-estradiol at physiological concentration (~50 pg/ml) also significantly increased secretion of many pro-inflammatory cytokines and chemokines (IL-6, IL-12, IL-17, IL-8, IFN-gamma; MIP1alpha, and MIP1beta) in both groups. Estradiol 78-94 interleukin 6 Homo sapiens 228-232 34681270-5 2021 Experimental results indicated that corylin attenuated LPS-induced IL-6 production in human bronchial epithelial cells (HBEC3-KT cells). corylin 36-43 interleukin 6 Homo sapiens 67-71 34682865-10 2021 Increased phosphorylation of Rictor at the Thr-1135 residue, AKT at the Ser-473 residue and PKCalpha at the Ser-657 residue were observed after treatment with IGF-1 and IL-6. Threonine 43-46 interleukin 6 Homo sapiens 169-173 34682865-10 2021 Increased phosphorylation of Rictor at the Thr-1135 residue, AKT at the Ser-473 residue and PKCalpha at the Ser-657 residue were observed after treatment with IGF-1 and IL-6. Serine 72-75 interleukin 6 Homo sapiens 169-173 34682865-10 2021 Increased phosphorylation of Rictor at the Thr-1135 residue, AKT at the Ser-473 residue and PKCalpha at the Ser-657 residue were observed after treatment with IGF-1 and IL-6. Serine 108-111 interleukin 6 Homo sapiens 169-173 34680153-9 2021 The IDO inhibitor 1-DL-methyl-tryptophan ameliorated the DDR; decreased p21, p16, and SA-beta-Gal activity; restored cell proliferation; and decreased IL-6 production. 1-dl-methyl-tryptophan 18-40 interleukin 6 Homo sapiens 151-155 34684771-8 2021 EAS significantly attenuated S1-induced secretion of interleukin (IL)-6 in a concentration-dependent manner without reducing cell viability. CHEMBL4167713 0-3 interleukin 6 Homo sapiens 53-71 34684771-9 2021 EAS also markedly suppressed the S1-induced transcription of IL-6 and IL-1beta. CHEMBL4167713 0-3 interleukin 6 Homo sapiens 61-65 34684771-13 2021 These results suggest that EAS attenuates S1-induced IL-6 and IL-1beta production by suppressing p44/42 MAPK and Akt signaling in macrophages. CHEMBL4167713 27-30 interleukin 6 Homo sapiens 53-57 34139285-0 2021 Cancer-associated fibroblasts induce monocytic myeloid-derived suppressor cell generation via IL-6/exosomal miR-21-activated STAT3 signaling to promote cisplatin resistance in esophageal squamous cell carcinoma. Cisplatin 152-161 interleukin 6 Homo sapiens 94-98 34712264-14 2021 Moreover, GSEA results indicated that the IL6/JAK/STAT3/SIGNALING pathway could be considered as a potential mechanism of genomic instability to influence tumor progression. gsea 10-14 interleukin 6 Homo sapiens 42-45 34682144-9 2021 Following dexamethasone treatment, there were significant decreases in respiratory severity score (RSS), percent CD4+IL-6+ cells, CD8+IL-6+ cells, CXCR3+IL-6+ cells, and CXCR3+IL-2+ cells and total intracellular IFN-gamma in TA. Dexamethasone 10-23 interleukin 6 Homo sapiens 117-121 34303665-1 2021 The aim of the current study was to perform a meta-analysis of randomized clinical trials regarding the effect of resveratrol in decreasing the levels of inflammatory cytokines, including interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha in a combination of inflammatory diseases. Resveratrol 114-125 interleukin 6 Homo sapiens 208-212 34303665-6 2021 A significant reduction of IL-6 concentration was observed only in the patients receiving >=500 mg/day dose of resveratrol (WMD = -1.89 pg/ml, 95% CI = -3.73 to -0.05, P = 0.04) with inter-study heterogeneity (I2 = 94.4%, P < 0.001). Resveratrol 111-122 interleukin 6 Homo sapiens 27-31 34303665-8 2021 Based on the present findings, resveratrol is able to decrease TNF-alpha and IL-6 (in >=500 mg/day dose) levels but not IL-1 and IL-8 levels. Resveratrol 31-42 interleukin 6 Homo sapiens 77-81 34639073-1 2021 Our objective is to reveal the molecular mechanism of the anti-inflammatory action of low-molecular-weight heparin (LMWH) based on its influence on the activity of two key cytokines, IFNgamma and IL-6. Heparin 107-114 interleukin 6 Homo sapiens 196-200 34639073-2 2021 The mechanism of heparin binding to IFNgamma and IL-6 and the resulting inhibition of their activity were studied by means of extensive molecular-dynamics simulations. Heparin 17-24 interleukin 6 Homo sapiens 49-53 34682144-11 2021 To our knowledge, this is the first study demonstrating that dexamethasone reduced T-cell IL-6 and this reduction was associated with improved RSS in pre-term infants with evolving BPD. Dexamethasone 61-74 interleukin 6 Homo sapiens 90-94 34682144-9 2021 Following dexamethasone treatment, there were significant decreases in respiratory severity score (RSS), percent CD4+IL-6+ cells, CD8+IL-6+ cells, CXCR3+IL-6+ cells, and CXCR3+IL-2+ cells and total intracellular IFN-gamma in TA. Dexamethasone 10-23 interleukin 6 Homo sapiens 134-138 34682144-9 2021 Following dexamethasone treatment, there were significant decreases in respiratory severity score (RSS), percent CD4+IL-6+ cells, CD8+IL-6+ cells, CXCR3+IL-6+ cells, and CXCR3+IL-2+ cells and total intracellular IFN-gamma in TA. Dexamethasone 10-23 interleukin 6 Homo sapiens 153-157 34279157-8 2021 RESULTS: Exosomal miR-143-3p was elevated after IL-6 treatment in the HCC cell line. mir-143-3p 18-28 interleukin 6 Homo sapiens 48-52 34596979-3 2021 In this study, we compared the binding of four inflammatory cytokines (CCL8, IL-1beta, IL-2 and IL-6) to immobilized heparin by an SPR analysis. Heparin 117-124 interleukin 6 Homo sapiens 96-100 34319506-9 2021 However, as compared with baseline data, a reduction in weight, BMI, hipline, WHR, fasting glucose, homeostatic model assessment of insulin sensitivity, visfatin and HDL-C, and an increase in resistin and IL-6 were observed in the true acupuncture group (P<0.05). Glucose 91-98 interleukin 6 Homo sapiens 205-209 34514543-10 2021 Conversely, alpha7 nAChR-specific agonist GTS-21 diminished the release of interleukin-1beta (IL-1beta), IL-6, IL-8, and tumor necrosis factor-alpha (TNFalpha) in SH-SY5Y cells under inflammatory conditions. 3-(2,4-dimethoxybenzylidene)anabaseine 42-48 interleukin 6 Homo sapiens 105-109 34431007-4 2021 It was found that different concentrations of melatonin could significantly inhibit the expression levels of NFkappaB and its downstream cytokines, including IL6 and IL8 in Caco-2 cells (*P < 0.05, **P < 0.01), 3D intestinal organoids (*P < 0.05, **P < 0.01) and intestinal explants (*P < 0.05, **P < 0.01). Melatonin 46-55 interleukin 6 Homo sapiens 158-161 34233590-8 2021 In addition, curcumin significantly inhibited the protein expression of IL-6R, STAT3, snail, survivin, and cyclin D1 in THLE-2 and HepG2 cells induced by IL-6. Curcumin 13-21 interleukin 6 Homo sapiens 154-158 34431007-5 2021 Melatonin abolished the activation of LPS on the expression levels of NFkappaB, IL6, and IL8 in three intestinal models (*P < 0.05, **P < 0.01, ***P < 0.001). Melatonin 0-9 interleukin 6 Homo sapiens 80-83 34410849-7 2021 Interestingly, both HI and MI upregulated gene sets involved in inflammation (IL6-JAK-STAT3 signaling, allograft rejection, TNFA signaling via NFKB, and inflammatory response; FDR q-value<0.25). Histidine 20-22 interleukin 6 Homo sapiens 78-81 34346143-11 2021 Arbutin treatment appreciably reduced the liver marker enzymes, upregulated superoxide dismutase, glutathione peroxidase, total antioxidant capacity, and the hydroxyl scavenging ability, and diminished the tumor necrosis factor-alpha and interleukin-6 levels in the serum of ethanol provoked animals. Ethanol 275-282 interleukin 6 Homo sapiens 238-251 34661247-7 2021 Spearman"s correlation analysis revealed that total testosterone levels were significantly and inversely correlated with NLR, high-sensitivity C-reactive protein (hsCRP), interleukin-6, D-dimer and PCT. Testosterone 52-64 interleukin 6 Homo sapiens 171-184 34402957-4 2021 Long-term exposure to high glucose significantly enhanced the increase in the production of pro-inflammatory cytokines, including tumor necrosis-alpha, interleukin (IL)-1beta, and IL-6, when macrophages were stimulated with LPS. Glucose 27-34 interleukin 6 Homo sapiens 180-184 34233590-9 2021 CONCLUSION: Curcumin has anti-inflammatory and anti-proliferative effects, and inhibits the development of HCC induced by TCE by reversing IL-6/STAT3 mediated EMT. Curcumin 12-20 interleukin 6 Homo sapiens 139-143 34632152-4 2021 Exposure of HUVEC to elevated sodium within the physiological range up to 24 h is accompanied by changes in monovalent cations fluxes and Na,K-ATPase activation, and, in turn, results in a significant decrease in the content of PTGS2, IL6 and IL1LR1 mRNAs. Sodium 30-36 interleukin 6 Homo sapiens 235-238 34703823-8 2021 Furthermore, 15d-PGJ2 inhibited interleukin-6-induced tyrosine phosphorylation of STAT3 in LNCaP cells. Tyrosine 54-62 interleukin 6 Homo sapiens 32-45 34588424-4 2021 Blocking the IL-6 feedback loop with tocilizumab or apigenin prevented PGCC formation, attenuated embryonic stemness and the CAF phenotype, and inhibited tumor growth in a patient-derived xenograft high-grade serous ovarian carcinoma model. Apigenin 52-60 interleukin 6 Homo sapiens 13-17 34544857-0 2021 Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells. Serine 44-50 interleukin 6 Homo sapiens 0-13 34544857-3 2021 IL-6 blockade repressed the proliferation and migration of TSC2-deficient cells and reduced oxygen consumption and extracellular acidification. Oxygen 92-98 interleukin 6 Homo sapiens 0-4 34544857-4 2021 U-13C glucose tracing revealed that IL-6 knockout reduced 3-phosphoserine and serine production in TSC2-deficient cells, implicating IL-6 in de novo serine metabolism. Glucose 6-13 interleukin 6 Homo sapiens 36-40 34544857-4 2021 U-13C glucose tracing revealed that IL-6 knockout reduced 3-phosphoserine and serine production in TSC2-deficient cells, implicating IL-6 in de novo serine metabolism. Glucose 6-13 interleukin 6 Homo sapiens 133-137 34544857-4 2021 U-13C glucose tracing revealed that IL-6 knockout reduced 3-phosphoserine and serine production in TSC2-deficient cells, implicating IL-6 in de novo serine metabolism. Serine 78-84 interleukin 6 Homo sapiens 36-40 34544857-4 2021 U-13C glucose tracing revealed that IL-6 knockout reduced 3-phosphoserine and serine production in TSC2-deficient cells, implicating IL-6 in de novo serine metabolism. Serine 78-84 interleukin 6 Homo sapiens 133-137 34544857-4 2021 U-13C glucose tracing revealed that IL-6 knockout reduced 3-phosphoserine and serine production in TSC2-deficient cells, implicating IL-6 in de novo serine metabolism. Serine 149-155 interleukin 6 Homo sapiens 36-40 34581012-5 2022 Upon blockade of the IL-6 signaling pathway by an anti-IL-6 treatment, the AUCs of S-warfarin, omeprazole and midazolam were predicted to decrease by up to 40%, 42%, and 46%, respectively. Omeprazole 95-105 interleukin 6 Homo sapiens 21-25 34581012-5 2022 Upon blockade of the IL-6 signaling pathway by an anti-IL-6 treatment, the AUCs of S-warfarin, omeprazole and midazolam were predicted to decrease by up to 40%, 42%, and 46%, respectively. Omeprazole 95-105 interleukin 6 Homo sapiens 55-59 34544857-4 2021 U-13C glucose tracing revealed that IL-6 knockout reduced 3-phosphoserine and serine production in TSC2-deficient cells, implicating IL-6 in de novo serine metabolism. Serine 149-155 interleukin 6 Homo sapiens 133-137 34581012-8 2022 With further validation with relevant clinical data, this PBPK model may provide an in-silico way to quantify the magnitude of potential TP-DI in patients with elevated IL-6 levels when an anti-IL-6 therapeutic is used with concomitant small-molecule drugs. tp-di 137-142 interleukin 6 Homo sapiens 169-173 34544857-5 2021 IL-6 knockout reduced expression of phosphoserine aminotransferase 1 (PSAT1), an essential enzyme in serine biosynthesis. Serine 101-107 interleukin 6 Homo sapiens 0-4 34581012-8 2022 With further validation with relevant clinical data, this PBPK model may provide an in-silico way to quantify the magnitude of potential TP-DI in patients with elevated IL-6 levels when an anti-IL-6 therapeutic is used with concomitant small-molecule drugs. tp-di 137-142 interleukin 6 Homo sapiens 194-198 34683106-3 2021 Methoss: Our purpose was to analyze whether certain inflammatory markers, i.e., interleukin 6 (IL-6) and endothelin 1 (ET-1), can play a role in the diagnosis of microvascular angina in women. methoss 0-7 interleukin 6 Homo sapiens 80-93 34683106-3 2021 Methoss: Our purpose was to analyze whether certain inflammatory markers, i.e., interleukin 6 (IL-6) and endothelin 1 (ET-1), can play a role in the diagnosis of microvascular angina in women. methoss 0-7 interleukin 6 Homo sapiens 95-99 34579742-10 2021 Serum 25(OH)D exhibited positive correlation with hemoglobin (r = 0.4509, p = 0.0002), RBC (r = 0.3712, p = 0.0030), TIBC (r = 0.4700, p = 0.0001), SOD (r = 0.4992, p < 0.0001) and GSH-Px (r = 0.4312, p = 0.0005), and negative correlation with hs-CRP (r = - 0.4040, p = 0.0011), TNF-alpha (r = - 0.4721, p = 0.0001), IL-6 (r = - 0.5378, p < 0.0001) and MDA (r = - 0.3056, p = 0.0157). 25(oh)d 6-13 interleukin 6 Homo sapiens 317-321 34572149-8 2021 In addition, metformin, a potential inhibitor of TLR4, also decreased expression of COX-2 and IL-6 induced by co-incubation with IL-26 and palmitate. Metformin 13-22 interleukin 6 Homo sapiens 94-98 34680892-1 2021 Interleukin 6 (IL-6) is a cytokine with both pro- and anti-inflammatory actions, but is also considered as a "metabolic hormone" involved in immune responses, affecting glucose, protein and lipid metabolism. Glucose 169-176 interleukin 6 Homo sapiens 0-13 34680892-1 2021 Interleukin 6 (IL-6) is a cytokine with both pro- and anti-inflammatory actions, but is also considered as a "metabolic hormone" involved in immune responses, affecting glucose, protein and lipid metabolism. Glucose 169-176 interleukin 6 Homo sapiens 15-19 34638272-11 2021 Two M1 markers (CXCL10 and IL6) were significantly increased in monocytes when treated with exosomes from IH-exposed CRL-1424 and CRL-1625 cells. Ile-His 106-108 interleukin 6 Homo sapiens 27-30 34539932-2 2021 These contaminants induce reactive oxygen species (ROS) and increased pro-inflammatory cytokines such as IL-1beta, IL-6, and IL-8, triggering the inflammatory response that alters cell and tissue homeostasis and facilitates the development of diseases. Reactive Oxygen Species 51-54 interleukin 6 Homo sapiens 115-119 34664888-2 2021 Systemic pro-inflammatory cytokines released from synovial tissues in rheumatoid arthritis, such as interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha, could have direct effects on cardiac electrophysiology, particularly changes in the expression and function of potassium and calcium channels, resulting in QT interval prolongation on surface electrocardiogram (ECG) and an increased predisposition to develop lethal ventricular arrhythmias. Calcium 288-295 interleukin 6 Homo sapiens 124-128 34174586-3 2021 This study aimed to evaluate the clinical significance of serum IL-6 level as a biomarker of disease activity in patients with anti-acetylcholine receptor (AChR) antibody-positive MG. Acetylcholine 132-145 interleukin 6 Homo sapiens 64-68 34536415-8 2022 RESULTS: Mutant HCK lacking the C-terminal inhibitory tyrosine Tyr522 exhibited increased kinase activity and enhanced myeloid cell priming, migration and effector functions, such as production of the inflammatory cytokines IL-1beta, IL-6, IL-8 and TNFalpha and production of reactive oxygen species. Tyrosine 54-62 interleukin 6 Homo sapiens 234-238 34506568-10 2021 Correlation analysis showed that levels of LPS from severe patients were positively associated with IL-6 and IFN-gamma plasma concentrations and with IL-1beta transcripts, while IL-6 had a positive correlation with the cortisol/DHEA ratio. Hydrocortisone 219-227 interleukin 6 Homo sapiens 178-182 34660145-3 2021 Tofacitinib is an effective JAK1 and JAK3 inhibitor that can block several cytokines such as IL-2, IL-7, and IL-6. tofacitinib 0-11 interleukin 6 Homo sapiens 109-113 34370712-7 2021 Furthermore, preliminary data show an inverse association between serum sodium and interleukin-6 levels, suggesting that hyponatraemia might be used as a surrogate marker for the risk of a cytokine storm and the need for treatment with interleukin antagonists. Sodium 72-78 interleukin 6 Homo sapiens 83-96 34286801-4 2021 In macrophages, melanoidins significantly suppress the mRNA expression of interleukin (Il)-6, Il-1beta and tumor necrosis factor alpha (Tnf-alpha) with a concomitant inhibitory effect on IL-1beta, IL-6 and TNFalpha secretion, which are increased by ethanol. Ethanol 249-256 interleukin 6 Homo sapiens 74-92 34286801-4 2021 In macrophages, melanoidins significantly suppress the mRNA expression of interleukin (Il)-6, Il-1beta and tumor necrosis factor alpha (Tnf-alpha) with a concomitant inhibitory effect on IL-1beta, IL-6 and TNFalpha secretion, which are increased by ethanol. Ethanol 249-256 interleukin 6 Homo sapiens 197-201 34585000-15 2021 In NaCl (control) group there is a increase delta IL-6 on day-3 (4.3 pg/mg protein) and on day-7 (35.5 pg/mg protein). Sodium Chloride 3-7 interleukin 6 Homo sapiens 50-54 34576798-8 2021 The significant overall damages exerted by the immune-mediated responses under the hyper-expression of proinflammatory cytokines and interleukins, such as IL-6, may be facilitated by either a decreased level of vitamin D or the ageing process. Vitamin D 211-220 interleukin 6 Homo sapiens 155-159 34493195-7 2022 RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients. Berberine 122-131 interleukin 6 Homo sapiens 251-254 34493195-7 2022 RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients. hederagenin 133-144 interleukin 6 Homo sapiens 251-254 34575489-4 2021 The results showed that MNP-Dex/PCA exert an anti-inflammatory activity at non-cytotoxic and therapeutically relevant concentrations of PCA (350 muM) as supported by the reduced levels of inflammatory molecules such as MCP-1, IL-1beta, TNF-alpha, IL-6, and CCR2 in activated EC and M1-type macrophages and functional monocyte adhesion assay. protocatechuic acid 32-35 interleukin 6 Homo sapiens 247-251 34575489-4 2021 The results showed that MNP-Dex/PCA exert an anti-inflammatory activity at non-cytotoxic and therapeutically relevant concentrations of PCA (350 muM) as supported by the reduced levels of inflammatory molecules such as MCP-1, IL-1beta, TNF-alpha, IL-6, and CCR2 in activated EC and M1-type macrophages and functional monocyte adhesion assay. protocatechuic acid 136-139 interleukin 6 Homo sapiens 247-251 34107055-5 2021 Tofacitinib impairs IL-6/IFN/LPS-induced STAT1 and STAT3 phosphorylation in RA MPhis and FLS. tofacitinib 0-11 interleukin 6 Homo sapiens 20-24 34289257-5 2021 Interleukin (IL) 1beta, IL6, and tumor necrosis factor (TNF) alpha messenger RNA (mRNA) expressions were analyzed in freshly isolated and cultured PBMCs with phytohemagglutinin and phorbol myristate acetate stimulation by real-time reverse transcription polymerase chain reaction and serum MMP3 by enzyme-linked immunosorbent assay (ELISA). Tetradecanoylphorbol Acetate 181-206 interleukin 6 Homo sapiens 24-27 34302321-0 2021 Effects of Atorvastatin on T-Cell Activation and Apoptosis in Systemic Lupus Erythematosus and Novel Simulated Interactions With C-Reactive Protein and Interleukin 6. Atorvastatin 11-23 interleukin 6 Homo sapiens 152-165 34302321-12 2021 Atorvastatin interacted strongly with C-reactive protein (CRP) and also significantly with IL-6. Atorvastatin 0-12 interleukin 6 Homo sapiens 91-95 34302321-17 2021 We determine for the first time simulated interaction between atorvastatin, CRP, and IL-6, implying a novel role of atorvastatin. Atorvastatin 62-74 interleukin 6 Homo sapiens 85-89 34302321-17 2021 We determine for the first time simulated interaction between atorvastatin, CRP, and IL-6, implying a novel role of atorvastatin. Atorvastatin 116-128 interleukin 6 Homo sapiens 85-89 34345269-7 2021 High plasma serum levels of IL-6 were found to be correlated with cholesterol, high density lipoprotein cholesterol and triglyceride serum levels in the patients with OLP. Triglycerides 120-132 interleukin 6 Homo sapiens 28-32 34546869-8 2021 We also observed activation of TLR2 and inhibition of TLR2 signalling using TLR1/2 inhibitor CU-CPT22-blocked production of inflammatory cytokines IL6 and TNF-alpha from virus-infected N9 microglial cells. Copper 93-95 interleukin 6 Homo sapiens 147-150 34375503-8 2021 Using the STAT3 inhibitor stattic to block the IL-6/STAT3 signaling pathway strongly increased the sensitivity of ZIPK-expressed cells to cisplatin. Cisplatin 138-147 interleukin 6 Homo sapiens 47-51 34375503-9 2021 In conclusion, ZIPK may play a role in cisplatin resistance through activation of the IL-6/ STAT3 signaling pathway. Cisplatin 39-48 interleukin 6 Homo sapiens 86-90 34345269-7 2021 High plasma serum levels of IL-6 were found to be correlated with cholesterol, high density lipoprotein cholesterol and triglyceride serum levels in the patients with OLP. Cholesterol 66-77 interleukin 6 Homo sapiens 28-32 34252445-3 2021 Based on our experimental data, 24 hours after treatment with fusarotoxins, hydrogen peroxide levels, intracellular oxidative stress and the amounts of inflammatory interleukins IL-6 and IL-8 significantly increased. fusarotoxins 62-74 interleukin 6 Homo sapiens 178-182 34389624-0 2021 Differential Regulation of ATP- and UTP-Evoked Prostaglandin E2 and IL-6 Production from Human Airway Epithelial Cells. Adenosine Triphosphate 27-30 interleukin 6 Homo sapiens 68-72 34389624-5 2021 In this study, we find that the production of PGE2 and IL-6 following stimulation of human AECs by the damage-associated molecular pattern extracellular ATP shares a common requirement for Ca2+ release-activated Ca2+ (CRAC) channels. Adenosine Triphosphate 153-156 interleukin 6 Homo sapiens 55-59 34389624-7 2021 By contrast, ATP-evoked synthesis of IL-6 occurred via activation of ionotropic P2X receptors and CRAC channel-mediated calcineurin/NFAT signaling. Adenosine Triphosphate 13-16 interleukin 6 Homo sapiens 37-41 34389624-8 2021 In contrast to ATP, which elicited the production of both PGE2 and IL-6, the uridine nucleotide, UTP, stimulated PGE2 but not IL-6 production. Adenosine Triphosphate 15-18 interleukin 6 Homo sapiens 67-71 34288404-10 2021 Postprandial adiponectin was positively associated with malondialdehyde and inversely associated with interleukin-6 following DEX and also negatively associated with metabolic parameters after both test meals. Glucose 126-129 interleukin 6 Homo sapiens 102-115 34304130-17 2021 Also, YAN alleviated ethanol-induced inflammation by down-regulating the inflammation-related gene IL-6, IL-1beta and TNF-alpha expression. Ethanol 21-28 interleukin 6 Homo sapiens 99-103 34175668-6 2021 The data presented here provide evidence of the role of GSNO in shifting B cell immune balance (IL-10 > IL-6) and the preclinical relevance of N6022, a first-in-class drug targeting GSNOR with proven human safety, as therapeutics for autoimmune disorders including multiple sclerosis. S-Nitrosoglutathione 56-60 interleukin 6 Homo sapiens 104-108 34532317-8 2021 The IL-6-mediated enhanced osmotic sensitivity of RA-FLS likely involves NKCC1 and aquaporin-1, which mainly constitute the volume-associated ion transporter and water channel elements. Water 162-167 interleukin 6 Homo sapiens 4-8 34259316-8 2021 Compared with those in the DSS group, the expressions of IL-1beta, IL-6, IL-17, and TNF-alpha in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated. Mesalamine 117-138 interleukin 6 Homo sapiens 67-71 34259316-8 2021 Compared with those in the DSS group, the expressions of IL-1beta, IL-6, IL-17, and TNF-alpha in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated. 5-Aminosalicylic acid 140-145 interleukin 6 Homo sapiens 67-71 34464543-11 2021 COVID-19 patients with low vitamin D levels had a greater prevalence of hypertension and cardiovascular diseases, abnormally high serum troponin and peak D-dimer levels, as well as elevated interleukin-6 and C-reactive protein than those with serum 25(OH)D levels >=30 ng/ml. Vitamin D 27-36 interleukin 6 Homo sapiens 190-203 34461991-1 2021 BACKGROUND: This study aimed to investigate the interaction effect of aerobic exercise and vitamin D supplementation on inflammation (TNF-alpha, IL-6, CC16, SP-D, and CC16/SP-D ratio) and lung function (FEV1, FVC, and FEV1/FVC ratio) in male smokers. Vitamin D 91-100 interleukin 6 Homo sapiens 145-149 34486582-7 2021 CONCLUSIONS: Keratoconus eyes that are progressing have a higher concentration of IL-6 and long-term cortisol than patients with stable forms of KC;Second, there is a significant correlation between this increase in IL6 and cortisol with corneal structural damage.Finally, there is a meaningful relationship between this interleukin and the past few months" cortisol levels. Hydrocortisone 101-109 interleukin 6 Homo sapiens 216-219 34483461-2 2021 The objective of our study is to unravel the binding mechanism of the Food and Drug Administration (FDA)-approved dexamethasone (Dex) and boceprevir (Boc) drugs with selected COVID-19 protein targets SARS-CoV-2 spike protein C-terminal domain (spike-CTD), main protease (Mpro), and interleukin-6 (IL-6). Dexamethasone 114-127 interleukin 6 Homo sapiens 282-295 34483461-2 2021 The objective of our study is to unravel the binding mechanism of the Food and Drug Administration (FDA)-approved dexamethasone (Dex) and boceprevir (Boc) drugs with selected COVID-19 protein targets SARS-CoV-2 spike protein C-terminal domain (spike-CTD), main protease (Mpro), and interleukin-6 (IL-6). Dexamethasone 114-127 interleukin 6 Homo sapiens 297-301 34483461-2 2021 The objective of our study is to unravel the binding mechanism of the Food and Drug Administration (FDA)-approved dexamethasone (Dex) and boceprevir (Boc) drugs with selected COVID-19 protein targets SARS-CoV-2 spike protein C-terminal domain (spike-CTD), main protease (Mpro), and interleukin-6 (IL-6). Dexamethasone 129-132 interleukin 6 Homo sapiens 282-295 34502044-8 2021 In addition, our results demonstrated reductions in beta- human chorionic gonadotropin (hCG), progesterone, and interleukin (IL)-6, which is likely a result from the activation of the cyclic adenosine monophosphate (cAMP)- cAMP-dependent protein kinase A (PKA)-phosphorylating CREB (pCREB) pathway. Adenosine 191-200 interleukin 6 Homo sapiens 112-130 34502044-8 2021 In addition, our results demonstrated reductions in beta- human chorionic gonadotropin (hCG), progesterone, and interleukin (IL)-6, which is likely a result from the activation of the cyclic adenosine monophosphate (cAMP)- cAMP-dependent protein kinase A (PKA)-phosphorylating CREB (pCREB) pathway. Cyclic AMP 216-220 interleukin 6 Homo sapiens 112-130 34484339-0 2021 Effect of Entecavir Combined with Adefovir Dipivoxil on Clinical Efficacy and TNF-alpha and IL-6 Levels in Patients with Hepatitis B Cirrhosis. entecavir 10-19 interleukin 6 Homo sapiens 92-96 34484339-1 2021 Objective: The purpose of the study was to investigate the effect of entecavir combined with adefovir dipivoxil on clinical efficacy and TNF-alpha and IL-6 levels in patients with hepatitis B cirrhosis. entecavir 69-78 interleukin 6 Homo sapiens 151-155 34443939-0 2021 Laser Scribing Fabrication of Graphitic Carbon Biosensors for Label-Free Detection of Interleukin-6. Carbon 40-46 interleukin 6 Homo sapiens 86-99 34411141-0 2021 The calcium-binding protein S100B reduces IL6 production in malignant melanoma via inhibition of RSK cellular signaling. Calcium 4-11 interleukin 6 Homo sapiens 42-45 34428217-5 2021 Experiments demonstrate for the first time that plasma concentrations of Acetylsalicylic acid significantly increased TLR ligand-triggered IL-1beta, IL-10, and IL-6 production in a dose-dependent manner. Aspirin 73-93 interleukin 6 Homo sapiens 160-164 34445661-5 2021 The CD73 inhibitor AMPCP significantly increased IL-6 and decreased IL-10 in both cell types, while TNF only increased in RA cells. alpha,beta-methyleneadenosine 5'-diphosphate 19-24 interleukin 6 Homo sapiens 49-53 34445661-8 2021 Taken together, OA and RA synoviocytes express the complete enzymatic machinery to synthesize adenosine/inosine; however, mainly adenosine is responsible for the anti- (IL-6 and IL-10) or pro-inflammatory (TNF) effects mediated by A2A- and A2BAR. Adenosine 129-138 interleukin 6 Homo sapiens 169-173 34443939-3 2021 Here we present an electrochemical immunosensor platform based on the use of highly porous graphitic carbon electrodes fabricated by direct laser writing of commercial polyimide tapes and chemically modified with capture IL-6 antibodies. Carbon 101-107 interleukin 6 Homo sapiens 221-225 34533012-7 2021 Interleukin 6 provides an energy substrate for contracting muscle fibers, fibroblast growth factor 21 activates the mechanisms of energy production during fasting and improves tissue sensitivity to insulin; irisin stimulates thermogenesis, glucose uptake by myocytes, and also contributes to an increase in bone mineral density. Glucose 240-247 interleukin 6 Homo sapiens 0-13 34483914-3 2021 Remdesivir and cyclosporine also separately reduced IL-6 production induced by HCoV-OC43 in human lung fibroblasts MRC-5 cells with EC50 values of 224 +- 53 nM and 1,292 +- 352 nM, respectively; and synergistically reduced it when combined. Cyclosporine 15-27 interleukin 6 Homo sapiens 52-56 34370644-0 2022 Design and Synthesis of Novel Ibuprofen Derivatives as Selective COX-2 inhibitors and potential anti-inflammatory agents: Evaluation of PGE2, TNF-alpha, IL-6 and histopathological study. Ibuprofen 30-39 interleukin 6 Homo sapiens 153-157 34440184-6 2021 In intermittent treatment, cortisol acted mainly as an anti-inflammatory hormone, repressing gene expression of kinin B1 receptors, interleukin-6, and interleukin-1beta. Hydrocortisone 27-35 interleukin 6 Homo sapiens 132-145 34434187-4 2021 Here, we described that in vitro atorvastatin (ATO) treatment was not toxic to splenocytes, constrained cell proliferation and modulated IL-6 and IL-10 production in a dose-dependent manner. Atorvastatin 33-45 interleukin 6 Homo sapiens 137-141 34434187-4 2021 Here, we described that in vitro atorvastatin (ATO) treatment was not toxic to splenocytes, constrained cell proliferation and modulated IL-6 and IL-10 production in a dose-dependent manner. Atorvastatin 47-50 interleukin 6 Homo sapiens 137-141 34443321-5 2021 AA/ LPS-induced TNF-alpha, MCP-1, IL-6, IL-8, and COX-2 markers were markedly attenuated by BBR treatment in THP-1 cells by inhibiting NF-kappaB translocation into the nucleus. Berberine 92-95 interleukin 6 Homo sapiens 34-38 34421621-5 2021 We found that puerarin inhibited liver injury and inflammatory cell infiltration in lipopolysaccharide (LPS)/D-galactose (D-Gal)-induced acute liver failure and the liver pro-inflammatory cytokines interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha (TNF-alpha) in liver tissues with ALI and LPS-induced L-02 cells but upregulated the expression level of zinc finger E-box-binding homeobox 2 (ZEB2). puerarin 14-22 interleukin 6 Homo sapiens 222-226 34424286-6 2021 Results: In the MDR-PA group, significantly (P < 0.05) increased expression of IL-6, IL-8, IL-10, IL-1beta, and TNF-alpha was observed in comparison with the S-PA group. mdr-pa 16-22 interleukin 6 Homo sapiens 79-83 34089945-5 2021 In addition, the most potent derivatives 2a and 2d inhibited the oncogenic function of STAT3 as seen in the inhibition of colony formation and IL-6 production of breast cancer cell lines. Echothiophate Iodide 48-50 interleukin 6 Homo sapiens 143-147 34132362-0 2021 miR-375/Yes-associated protein axis regulates IL-6 and TGF-beta expression, which is involved in the cisplatin-induced resistance of liver cancer cells. Cisplatin 101-110 interleukin 6 Homo sapiens 46-50 34459125-8 2021 Subsequently, TNF-alpha, IL-1beta, and lactate activated CAFs, and facilitated the secretion of IL-6, IL-7, IL-8, CCL5, and transforming growth factor-beta1 from CAFs. Lactic Acid 39-46 interleukin 6 Homo sapiens 96-100 34259987-9 2021 In contrast, treatment with the autophagy inducer trehalose (Tre) restored phagocytosis, TNF-alpha and IL-6 secretion, and MHC-II expression in GEM-induced immune-inhibited macrophages. Trehalose 50-59 interleukin 6 Homo sapiens 103-107 34259987-9 2021 In contrast, treatment with the autophagy inducer trehalose (Tre) restored phagocytosis, TNF-alpha and IL-6 secretion, and MHC-II expression in GEM-induced immune-inhibited macrophages. Trehalose 61-64 interleukin 6 Homo sapiens 103-107 34334139-5 2021 These actions of sodium, potassium and magnesium and other minerals, trace elements and vitamins are likely to be secondary to their action on pro-inflammatory cytokines IL-6, TNF-alpha and IL-17 and metabolism of essential fatty acids that may account for their involvement in the pathobiology of insulin resistance, T2DM, HTN and autoimmune diseases. Sodium 17-23 interleukin 6 Homo sapiens 170-174 34293716-10 2021 Consistent with this model, the overexpression of IL-6 reversed the OGFRP1 knockdown-mediated reductions in docetaxel and paclitaxel IC50 values for these PC cells. Paclitaxel 122-132 interleukin 6 Homo sapiens 50-54 34132362-8 2021 In conclusion, the findings of the present study suggested that the miR-375/YAP axis may regulate the expression levels of IL-6 and TGF-beta, which may subsequently be involved in the CDDP resistance of LC cells. Cisplatin 184-188 interleukin 6 Homo sapiens 123-127 34589801-11 2021 Estradiol during pregnancy was positively correlated with IL-6 levels both during pregnancy (r p = .656, p = .008) and postpartum (r = 0.648, p = .023). Estradiol 0-9 interleukin 6 Homo sapiens 58-62 34126229-10 2021 Summarizing earlier studies, we demonstrated that circulating concentrations of inflammatory cytokines such as CRP, TNF-alpha, and IL-6 might be decreased following vitamin D supplementation among individuals with AGH. Vitamin D 165-174 interleukin 6 Homo sapiens 131-135 34439757-6 2021 Additionally, the RA-RF significantly reduced ROS production, IL-6, IL-8, TNF-alpha, and COX-2. rosmarinic acid 18-20 interleukin 6 Homo sapiens 62-66 34321087-0 2021 Resveratrol protects human nucleus pulposus cells from degeneration by blocking IL-6/JAK/STAT3 pathway. Resveratrol 0-11 interleukin 6 Homo sapiens 80-84 34321087-3 2021 The goal of our study is to figure out whether or how resveratrol (RSV) can protect NPCs from degeneration by affecting IL6/JAK/STAT3 pathway. Resveratrol 54-65 interleukin 6 Homo sapiens 120-123 34321087-3 2021 The goal of our study is to figure out whether or how resveratrol (RSV) can protect NPCs from degeneration by affecting IL6/JAK/STAT3 pathway. Resveratrol 67-70 interleukin 6 Homo sapiens 120-123 34321087-12 2021 Moreover, RSV significantly attenuated the level of IL-6 secretion, which was accompanied by less phosphorylation of the transcription factors Janus kinase 1 (JAK1) and signal transducer and activator of transcription 3 (STAT3). Resveratrol 10-13 interleukin 6 Homo sapiens 52-56 34440697-3 2021 Our aim was to investigate whether there is an interaction between IL-6 and nucleotide signaling, in particular, that mediated by the ATP-sensing P2X7 receptor (P2X7R). Adenosine Triphosphate 134-137 interleukin 6 Homo sapiens 67-71 34441262-9 2021 The odds ratio of IL-6 which was crude and adjusted for dexamethasone administration initiated before laboratory measurement, showed the high value of 29.1 (5.6-295.6) and 53.9 (4.5-3242.8), respectively. Dexamethasone 56-69 interleukin 6 Homo sapiens 18-22 34369925-6 2021 Similar percent drops in metabolic activity of the iHCEC and pHCEC occurred after exposure to BAK, H2O2, or SDS, and the most significant changes in cytokine release occurred for IL-6 and IL-8. Hydrogen Peroxide 99-103 interleukin 6 Homo sapiens 179-183 34115964-3 2021 We show that metformin inhibited NLRP3 inflammasome activation and interleukin (IL)-1beta production in cultured and alveolar macrophages along with inflammasome-independent IL-6 secretion, thus attenuating lipopolysaccharide (LPS)- and SARS-CoV-2-induced ARDS. Metformin 13-22 interleukin 6 Homo sapiens 174-178 34290243-3 2021 In vitro, 3-HKA has an anti-inflammatory profile by inhibiting the IFN-gamma mediated STAT1/NF-kappaBeta pathway in both mouse and human dendritic cells (DCs) with a consequent decrease in the release of pro-inflammatory chemokines and cytokines, most notably TNF, IL-6, and IL12p70. 3-hka 10-15 interleukin 6 Homo sapiens 265-269 34290255-3 2021 Here, we show that cancer-associated fibroblast (CAF)-activated stromal signaling, interleukin-6/8-JAK2, induces BRD4 phosphorylation at tyrosine 97/98 in colorectal cancer, resulting in BRD4 stabilization due to interaction with the deubiquitinase UCHL3. Tyrosine 137-145 interleukin 6 Homo sapiens 83-98 34284806-12 2021 Metformin promoted SFRP5 and decreased leptin, IL-6 and TNFalpha secretion in PCOS women with metabolic abnormality in a time dependent manner and with improved ovulation rate and pregnancy rate. Metformin 0-9 interleukin 6 Homo sapiens 47-51 34336088-2 2021 Reactive oxygen species- (ROS-) dependent proinflammatory cytokine production, such as interleukin-6 (IL-6), is a possible underlying mechanism. Reactive Oxygen Species 0-23 interleukin 6 Homo sapiens 87-100 34336088-2 2021 Reactive oxygen species- (ROS-) dependent proinflammatory cytokine production, such as interleukin-6 (IL-6), is a possible underlying mechanism. Reactive Oxygen Species 0-23 interleukin 6 Homo sapiens 102-106 34336088-2 2021 Reactive oxygen species- (ROS-) dependent proinflammatory cytokine production, such as interleukin-6 (IL-6), is a possible underlying mechanism. Reactive Oxygen Species 26-29 interleukin 6 Homo sapiens 87-100 34336088-2 2021 Reactive oxygen species- (ROS-) dependent proinflammatory cytokine production, such as interleukin-6 (IL-6), is a possible underlying mechanism. Reactive Oxygen Species 26-29 interleukin 6 Homo sapiens 102-106 34290862-7 2021 At the end of the study, CoQ10 administration caused a considerable reduction in the Malondialdehyde (MDA) and Interleukin 6 (IL-6) concentrations (P < 0 001), Glasgow Coma Score (GCS; P = 0 02), ICU and hospital length of stay and mechanical ventilation (MV) duration (P < 0 001). coenzyme Q10 25-30 interleukin 6 Homo sapiens 111-124 34253189-0 2021 Correction to: Mutant glucocorticoid receptor binding elements on the interleukin-6 promoter regulate dexamethasone effects. Dexamethasone 102-115 interleukin 6 Homo sapiens 70-83 34290862-7 2021 At the end of the study, CoQ10 administration caused a considerable reduction in the Malondialdehyde (MDA) and Interleukin 6 (IL-6) concentrations (P < 0 001), Glasgow Coma Score (GCS; P = 0 02), ICU and hospital length of stay and mechanical ventilation (MV) duration (P < 0 001). coenzyme Q10 25-30 interleukin 6 Homo sapiens 126-130 34226586-9 2021 Upregulated IL-6 induced resistance to 5-FU with STAT3 and Akt activation in ECs in an autocrine manner. Fluorouracil 39-43 interleukin 6 Homo sapiens 12-16 34236783-11 2022 As for cytokines, rapamycin or paclitaxel concentrations >=1 ug/mL could significantly increase the level of inflammatory cytokines IL-6 (P<0.05 or P<0.01), which was enhanced with the increase of drug concentration. Sirolimus 18-27 interleukin 6 Homo sapiens 132-136 34236783-11 2022 As for cytokines, rapamycin or paclitaxel concentrations >=1 ug/mL could significantly increase the level of inflammatory cytokines IL-6 (P<0.05 or P<0.01), which was enhanced with the increase of drug concentration. Paclitaxel 31-41 interleukin 6 Homo sapiens 132-136 34305638-16 2021 During alcohol detoxification, LS, transaminases, TGF- beta, IL-6, IL-8 and VEGF decreased significantly. Alcohols 7-14 interleukin 6 Homo sapiens 61-65 34299040-8 2021 Regarding LLD, interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) released in vivo are likely to contribute to the reduced serotonin level. Serotonin 137-146 interleukin 6 Homo sapiens 15-28 34299040-8 2021 Regarding LLD, interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) released in vivo are likely to contribute to the reduced serotonin level. Serotonin 137-146 interleukin 6 Homo sapiens 30-34 34253436-5 2022 The effects of povidone-iodine (PVP-I) on the secretion of IL-6 and PGE2 were also examined. Povidone-Iodine 15-30 interleukin 6 Homo sapiens 59-63 34253436-10 2022 The additive/synergistic effects of Pg-LPS/poly I:C on production of IL-6 and PGE2 were evident. Poly I 43-49 interleukin 6 Homo sapiens 69-73 34371837-3 2021 To bridge this knowledge gap, this systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the effects of folic acid supplementation on serum concentrations of the inflammatory markers C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha). Folic Acid 143-153 interleukin 6 Homo sapiens 248-261 34371837-3 2021 To bridge this knowledge gap, this systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the effects of folic acid supplementation on serum concentrations of the inflammatory markers C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha). Folic Acid 143-153 interleukin 6 Homo sapiens 263-267 34213019-9 2022 The autophagy inhibitor 3-methyladenine (3MA) significantly abrogated the LPS-sustained inflammatory effect by reducing the expression of IL-6, TNF-alpha, COX-2, and ICAM-1 in HGFs. 3-methyladenine 41-44 interleukin 6 Homo sapiens 138-142 34213019-9 2022 The autophagy inhibitor 3-methyladenine (3MA) significantly abrogated the LPS-sustained inflammatory effect by reducing the expression of IL-6, TNF-alpha, COX-2, and ICAM-1 in HGFs. 3-methyladenine 24-39 interleukin 6 Homo sapiens 138-142 34357020-7 2021 Dysfunctional mitochondria release high levels of reactive oxygen species (ROS), which can activate pro-inflammatory pathways such as IL-1beta and IL-6. Reactive Oxygen Species 50-73 interleukin 6 Homo sapiens 147-151 34357020-7 2021 Dysfunctional mitochondria release high levels of reactive oxygen species (ROS), which can activate pro-inflammatory pathways such as IL-1beta and IL-6. Reactive Oxygen Species 75-78 interleukin 6 Homo sapiens 147-151 34227646-3 2021 It was observed that the expression of IL-1beta, IL-6, IL-8 and TNFalpha in LPS-induced HGFs was significantly downregulated by RSV in a dose-dependent manner. Resveratrol 128-131 interleukin 6 Homo sapiens 49-53 34227646-6 2021 Subsequently, it was demonstrated treatment with PI3K/AKT pathway inhibitor (LY294002) or Wnt/beta-catenin pathway inhibitor (Dickkopf-1, DKK-1) could further enhance the anti-inflammatory and antioxidant effects of RSV by downregulating the expression of IL-1beta, IL-6, IL-8 and TNFalpha, and the production of MDA, and increasing the activity of SOD and GSH-Px in LPS-induced HGFs. Resveratrol 216-219 interleukin 6 Homo sapiens 266-270 34185112-6 2021 RESULTS: Compared with the high glucose group, the proliferation rate, migration rate, and the expression of alpha-SMA, bcl-2, TLR4, NF-kappaB, TNF-alpha, IL-6, IL- and IL-1 were significantly decreased in the high glucose + MSC-Exo-miR-26a mimics group, while the apoptosis rate and the expression of miR-26a, cleaved-caspase 3, cleaved-caspase 9 and Bax were significantly increased. Glucose 215-222 interleukin 6 Homo sapiens 155-159 34281061-3 2021 In monocytes/macrophages, vitamin D suppresses the production of the inflammatory cytokines TNF-alpha, IL-1beta, IL-6, and IL-8. Vitamin D 26-35 interleukin 6 Homo sapiens 113-117 34221262-1 2021 Aim: The associations between serum levels of melatonin and concentrations of tumor necrosis factor (TNF)-a and interleukin (IL)-6 were assessed among patients with different degrees of non-alcoholic fatty liver disease. Melatonin 46-55 interleukin 6 Homo sapiens 112-130 34277696-11 2021 Compared with the propofol group, BAL levels of IL-6 in the dependent ventilated lung were decreased in the sevoflurane group (three trials, 256 participants; standardized mean difference (SMD), -0.51; 95% confidence interval (CI), -0.90 to -0.11; p = 0.01; I 2 = 46%). Sevoflurane 108-119 interleukin 6 Homo sapiens 48-52 34277696-12 2021 The BAL levels of IL-6 in the independent ventilated lung were also decreased by sevoflurane (four trials, 362 participants; SMD, -0.70; 95% (CI), -0.93 to -0.47; p < 0.00001; I 2 = 0%). Sevoflurane 81-92 interleukin 6 Homo sapiens 18-22 34162145-1 2021 Following induction of inflammation, the nuclear factor kappa B (NF-kappaB) in activated macrophages induces the transcription of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and cyclooxygenase (COX), an inflammatory enzyme implicated in the synthesis of prostaglandins (PGs). Prostaglandins 338-352 interleukin 6 Homo sapiens 236-249 34162145-1 2021 Following induction of inflammation, the nuclear factor kappa B (NF-kappaB) in activated macrophages induces the transcription of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and cyclooxygenase (COX), an inflammatory enzyme implicated in the synthesis of prostaglandins (PGs). Prostaglandins 338-352 interleukin 6 Homo sapiens 251-255 34262937-13 2021 In addition, silencing STUB1 increased the apoptosis of HK-2 cells and the proinflammatory cytokine production of IL6, TNFalpha, and IL1beta induced by cisplatin. Cisplatin 152-161 interleukin 6 Homo sapiens 114-117 34185243-0 2021 The IL-6/STAT Signaling Pathway and PPARalpha Are Involved in Mediating the Dose-Dependent Cardioprotective Effects of Fenofibrate in 5-Fluorouracil-Induced Cardiotoxicity. Fluorouracil 134-148 interleukin 6 Homo sapiens 4-8 34185243-7 2021 RESULTS: The current study showed that 5FU succeeded in inducing cardiotoxicity, manifested by significantly elevated levels of cardiac enzymes, tissue malondialdehyde (MDA), interleukin 6 (IL-6), signal transducer and activator of transcription 4 (STAT4), and caspase-3. Fluorouracil 39-42 interleukin 6 Homo sapiens 175-188 34185243-7 2021 RESULTS: The current study showed that 5FU succeeded in inducing cardiotoxicity, manifested by significantly elevated levels of cardiac enzymes, tissue malondialdehyde (MDA), interleukin 6 (IL-6), signal transducer and activator of transcription 4 (STAT4), and caspase-3. Fluorouracil 39-42 interleukin 6 Homo sapiens 190-194 34276328-6 2021 It has been proposed that vagal efferent fibers release acetylcholine (Ach), which can interact with alpha7-subunit-containing nicotinic receptors expressed by tissue macrophages and other immune cells to rapidly inhibit the synthesis/release of pro-inflammatory cytokines such as TNFalpha, IL-1beta, IL-6, and IL-18. Acetylcholine 56-69 interleukin 6 Homo sapiens 301-305 34276328-6 2021 It has been proposed that vagal efferent fibers release acetylcholine (Ach), which can interact with alpha7-subunit-containing nicotinic receptors expressed by tissue macrophages and other immune cells to rapidly inhibit the synthesis/release of pro-inflammatory cytokines such as TNFalpha, IL-1beta, IL-6, and IL-18. Acetylcholine 71-74 interleukin 6 Homo sapiens 301-305 34161397-0 2021 Iron overload inhibits BMP/SMAD and IL-6/STAT3 signaling to hepcidin in cultured hepatocytes. Iron 0-4 interleukin 6 Homo sapiens 36-40 34258288-3 2021 Results: Adenosine-5"-N-ethyluronamide (NECA), a stable adenosine analogue, significantly stimulate inflammatory mediator (IL-6) (p < 0.001) and nuclear receptors (NR4A) (p < 0.05) and significantly modulate metabolic (PFK, LCAD, PGC-1alpha, and CPT1B) gene expressions in skeletal muscle cells (p < 0.05, p < 0.05, p < 0.001, and p < 0.01, respectively). Adenosine 9-18 interleukin 6 Homo sapiens 123-127 34202657-9 2021 Nano-curcumin supplementation also showed favorable anti-inflammatory effects by decreasing C-reactive protein (CRP) (WMD: -1.29 mg/L; 95% CI: -2.15 to -0.44; p = 0.003) and interleukin-6 (IL-6) (WMD: -2.78 mg/dL; 95% CI: -3.76 to -1.79; p< 0.001). Curcumin 5-13 interleukin 6 Homo sapiens 174-187 34202657-9 2021 Nano-curcumin supplementation also showed favorable anti-inflammatory effects by decreasing C-reactive protein (CRP) (WMD: -1.29 mg/L; 95% CI: -2.15 to -0.44; p = 0.003) and interleukin-6 (IL-6) (WMD: -2.78 mg/dL; 95% CI: -3.76 to -1.79; p< 0.001). Curcumin 5-13 interleukin 6 Homo sapiens 189-193 34161397-7 2021 Subsequent iron supplementation not only failed to reverse these effects, but drastically reduced basal HAMP mRNA and inhibited HAMP mRNA induction by BMP6 and/or IL-6. Iron 11-15 interleukin 6 Homo sapiens 163-167 34201855-0 2021 Dietary Acid Load and Its Interaction with IGF1 (rs35767 and rs7136446) and IL6 (rs1800796) Polymorphisms on Metabolic Traits among Postmenopausal Women. dietary acid 0-12 interleukin 6 Homo sapiens 76-79 34161397-9 2021 Iron also inhibited IL-6-mediated STAT3 phosphorylation and induction of HAMP and SOCS3 mRNAs. Iron 0-4 interleukin 6 Homo sapiens 20-24 34086734-13 2021 When comparing the cells incubated under high and low calcium conditions, the more differentiated cells in the high concentration were found to exert a stronger response in terms of IL-6 release. Calcium 54-61 interleukin 6 Homo sapiens 182-186 34220505-6 2021 In particular, Lf down-regulates the synthesis of IL-6, which is involved in iron homeostasis disorders and leads to intracellular iron overload, favoring viral replication and infection. Iron 131-135 interleukin 6 Homo sapiens 50-54 34220507-8 2021 Significantly, our results showed that Myricetin has potent effect on bleomycin-induced pulmonary inflammation by inhibiting the infiltration of inflammatory cells and the secretion of inflammatory cytokines IL-6, IL-1alpha, TNF-alpha and IFN-gamma. myricetin 39-48 interleukin 6 Homo sapiens 208-212 34208683-5 2021 As an anti-inflammatory compound, NAC can reduce levels of tumor necrosis factor-alpha (TNF-alpha) and interleukins (IL-6 and IL-1beta) by suppressing the activity of nuclear factor kappa B (NF-kappaB). Acetylcysteine 34-37 interleukin 6 Homo sapiens 117-121 34204678-8 2021 By contrast, tamoxifen decreased both CD8+ and B220+ populations in the spleen and decreased the serum levels of IL-2, IL-6, and IL-17. Tamoxifen 13-22 interleukin 6 Homo sapiens 119-123 34103463-7 2021 RESULTS Our results indicated that vitamin D promoted A549 cell survival following LPS-induced inflammation by downregulating nuclear factor nuclear factor kappa light chain enhancer of activated B cells, tumor necrosis factor-alpha, interleukin (IL)-1ss, IL-6, and IL-12. Vitamin D 35-44 interleukin 6 Homo sapiens 256-260 34201243-3 2021 The aim of this study was to evaluate the repositioning of the anti-cancer molecule irinotecan as a potential modulator of the antiviral and inflammatory responses of primary human synovial fibroblasts (HSF), the main stromal cells of the joint synovium. Irinotecan 84-94 interleukin 6 Homo sapiens 203-206 34201243-6 2021 Quantitative RT-PCR analysis revealed that irinotecan at 15 microM was able to amplify the antiviral response (i.e., interferon-stimulated gene expression) of HSF exposed to PIC and reduce the expression of pro-inflammatory genes (CXCL8, IL-6 and COX-2) upon IL-1beta treatment. Irinotecan 43-53 interleukin 6 Homo sapiens 159-162 34201243-6 2021 Quantitative RT-PCR analysis revealed that irinotecan at 15 microM was able to amplify the antiviral response (i.e., interferon-stimulated gene expression) of HSF exposed to PIC and reduce the expression of pro-inflammatory genes (CXCL8, IL-6 and COX-2) upon IL-1beta treatment. Irinotecan 43-53 interleukin 6 Homo sapiens 238-242 34200459-12 2021 In conclusion, high plasma HGF, CXCL11, CXCL10 and IL-6 levels are associated with worse outcome in mRCC patients treated with sunitinib or pazopanib. pazopanib 140-149 interleukin 6 Homo sapiens 51-55 34147675-8 2022 Cholesterol accumulation in cardiac muscle cells can result in a significant increase in the levels of BNP, inflammatory factors (IL-1beta, IL-6, TNF-alpha and CCL-2) in cardiac muscle cells, which exacerbates cardiomyocyte damage. Cholesterol 0-11 interleukin 6 Homo sapiens 140-144 34423270-6 2021 IL-6 expression also strongly correlated with the expression of COX-2 and other PGE2 synthetic pathway genes. Dinoprostone 80-84 interleukin 6 Homo sapiens 0-4 34208638-5 2021 SCFA down-attenuated host pro-inflammatory IL-1beta, IL-6, and TNFalpha response predominantly through the TLR4 pathway, whereas MCFA augmented inflammation through TLR2. Fatty Acids, Volatile 0-4 interleukin 6 Homo sapiens 53-57 34211953-8 2021 This is also confirmed by serum interleukin (IL)-6 and myeloperoxidase (MPO) that gradually increased with the disease stage in patients of the Ist wave, while such biomarkers (whose production is inhibited by steroids) did not show differences among patients of the IInd wave in different stages. Steroids 210-218 interleukin 6 Homo sapiens 32-50 34164408-6 2021 In contrast, the HMGB1-mediated expression of HLA-DR, CD40, and CD86 on dendritic cells and production of IL-1beta, IL-6, and TNF-alpha were reduced by rapamycin. Sirolimus 152-161 interleukin 6 Homo sapiens 116-120 34149863-13 2021 SCDP key active ingredients are mainly quercetin, wogonin, baicalein, acacetin, oroxylin A, and beta-sitosterol, which function mainly by regulating targets, such as PTGS2, CASP3, TP53, IL-6, TNF, and AKT1, and are associated with multiple signaling pathways as pathways in cancer, PI3K-Akt signaling pathway, apoptosis, IL-17 signaling pathways. 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one 80-90 interleukin 6 Homo sapiens 186-190 34088317-9 2021 The levels of IL-6 and TNF-alpha correlated with the levels of creatinine and urea nitrogen, and were also higher in ARDS patients with acute kidney injury (AKI). Creatinine 63-73 interleukin 6 Homo sapiens 14-18 34088317-9 2021 The levels of IL-6 and TNF-alpha correlated with the levels of creatinine and urea nitrogen, and were also higher in ARDS patients with acute kidney injury (AKI). Urea 78-82 interleukin 6 Homo sapiens 14-18 34088317-9 2021 The levels of IL-6 and TNF-alpha correlated with the levels of creatinine and urea nitrogen, and were also higher in ARDS patients with acute kidney injury (AKI). Nitrogen 83-91 interleukin 6 Homo sapiens 14-18 33577242-8 2021 With a BG concentration of 2.5%, IL-6 and IL-8 concentrations were smaller compared with the control group without BG after 2 days" incubation. O(6)-benzylguanine 7-9 interleukin 6 Homo sapiens 33-37 34543566-1 2021 OBJECTIVE: This study"s objective was to evaluate interleukin-6 (IL-6) and C-reactive protein (CRP) responses and performance changes in obese women after 8 weeks of aerobic training with an intensity of 50 to 60% of their individual maximum oxygen uptake (VO2). Oxygen 242-248 interleukin 6 Homo sapiens 50-63 34543566-1 2021 OBJECTIVE: This study"s objective was to evaluate interleukin-6 (IL-6) and C-reactive protein (CRP) responses and performance changes in obese women after 8 weeks of aerobic training with an intensity of 50 to 60% of their individual maximum oxygen uptake (VO2). Oxygen 242-248 interleukin 6 Homo sapiens 65-69 34467691-5 2021 The results revealed that the main compounds of Euodiae Fructus, such as berberine and rutaecarpine, participated in the biological processes(such as neurotransmitter receptor activity) by regulating C-reactive protein(CRP), estrogen receptor 1(ESR1), 5-hydroxytryptamine(5-HT) receptor, and interleukin-6(IL-6) to exert sedative, anxiolytic, and antidepressant effects. Berberine 73-82 interleukin 6 Homo sapiens 306-310 34075143-9 2021 HREC, which became senescent in the presence of GLU, demonstrated higher expression of genes regulating the synthesis of Il6 and VEGF-A, which was reflected by increased secretion of these cytokines (IL6 + 125%, p < 0.001 vs control and VEGF-A + 124% p < 0.001 vs control). Glutamic Acid 48-51 interleukin 6 Homo sapiens 121-124 34075143-9 2021 HREC, which became senescent in the presence of GLU, demonstrated higher expression of genes regulating the synthesis of Il6 and VEGF-A, which was reflected by increased secretion of these cytokines (IL6 + 125%, p < 0.001 vs control and VEGF-A + 124% p < 0.001 vs control). Glutamic Acid 48-51 interleukin 6 Homo sapiens 200-203 34122411-0 2021 Curcumin Blunts IL-6 Dependent Endothelial-to-Mesenchymal Transition to Alleviate Renal Allograft Fibrosis Through Autophagy Activation. Curcumin 0-8 interleukin 6 Homo sapiens 16-20 34071431-8 2021 Through the BMR measurements, peak carbohydrate metabolism changed significantly based upon IL-6 values, which were significantly correlated with the respiratory coefficient values. Carbohydrates 35-47 interleukin 6 Homo sapiens 92-96 34122411-4 2021 Here we demonstrate that inhibition of autophagy by treatment with 3-methyladenine (3-MA) or by silencing autophagy-related (ATG)5 promoted interleukin (IL)-6-dependent EndMT in human umbilical vein endothelial cells (HUVECs) and human renal glomerular endothelial cells (HRGECs), and autophagy inactivation was associated with EndMT in patients with chronic allograft dysfunction. 3-methyladenine 67-82 interleukin 6 Homo sapiens 140-158 34122411-4 2021 Here we demonstrate that inhibition of autophagy by treatment with 3-methyladenine (3-MA) or by silencing autophagy-related (ATG)5 promoted interleukin (IL)-6-dependent EndMT in human umbilical vein endothelial cells (HUVECs) and human renal glomerular endothelial cells (HRGECs), and autophagy inactivation was associated with EndMT in patients with chronic allograft dysfunction. 3-methyladenine 84-88 interleukin 6 Homo sapiens 140-158 34122411-5 2021 IL-6 level was significantly higher in the culture medium of HUVECs transfected with ATG5 siRNA or treated with 3-MA compared to the respective control groups. 3-methyladenine 112-116 interleukin 6 Homo sapiens 0-4 34122411-9 2021 This is the first demonstration of the role of autophagy in renal allograft fibrosis; our findings indicate that curcumin can alleviate chronic renal allograft injury by suppressing IL-6-dependent EndMT via activation of autophagy. Curcumin 113-121 interleukin 6 Homo sapiens 182-186 34063891-6 2021 PEG-BA inhibited the production of IL-6 by 4-5.5 fold compared to BA-treated cells. betulinic acid 66-68 interleukin 6 Homo sapiens 35-39 34079331-13 2021 Melatonin suppressed PCa cells migration and invasion by blocking EMT mediated by IL-6/STAT3, AKT/GSK-3beta and beta-catenin pathways. Melatonin 0-9 interleukin 6 Homo sapiens 82-86 34094941-0 2021 lncRNA MIAT/HMGB1 Axis Is Involved in Cisplatin Resistance via Regulating IL6-Mediated Activation of the JAK2/STAT3 Pathway in Nasopharyngeal Carcinoma. Cisplatin 38-47 interleukin 6 Homo sapiens 74-77 34094941-8 2021 We find that the deficiency of the lncRNA MIAT/HMGB1 axis, inhibition of JAK2/STAT3, or neutralization of IL6 by antibodies significantly re-sensitizes resistant NPC cells to cisplatin in resistant NPC cells. Cisplatin 175-184 interleukin 6 Homo sapiens 106-109 34064531-5 2021 The inflammatory adipocytokines, TNF-alpha, IL-1beta, and IL-6, were increased in the salt-treated Tg(+/+) WAT, but an anti-inflammation biomarker, the adiponectin/leptin ratio, was reduced in Tg(+/+), to tenth of that in Tg(-/-). Salts 86-90 interleukin 6 Homo sapiens 58-62 34069696-2 2021 Haplopine (12.5 and 25 muM) inhibited the mRNA expressions of inflammatory cytokines IL-6, TSLP, GM-CSF, and G-CSF and the protein expressions of IL-6 and GM-CSF in TNF-alpha/INF-gamma-stimulated HaCaT cells. 4,8-dimethoxy-7-hydroxyfuro(2,3-b)quinoline 0-9 interleukin 6 Homo sapiens 85-89 34069696-2 2021 Haplopine (12.5 and 25 muM) inhibited the mRNA expressions of inflammatory cytokines IL-6, TSLP, GM-CSF, and G-CSF and the protein expressions of IL-6 and GM-CSF in TNF-alpha/INF-gamma-stimulated HaCaT cells. 4,8-dimethoxy-7-hydroxyfuro(2,3-b)quinoline 0-9 interleukin 6 Homo sapiens 146-150 34064967-7 2021 Using multivariable linear or Tobit regression analyses, we found that CBMCs production of IL-6, TNF-a, and IL-10 were all lower in mothers exposed to higher levels of PM2.5 during pregnancy. cbmcs 71-76 interleukin 6 Homo sapiens 91-95 34064969-6 2021 Exposure to macrophages and elevated glucose levels (25 mM glucose) impacted gene expression of EMT inducers such as IL-6 and TNF-alpha as well as EMT transcription factors in benign (H6c7-pBp) and premalignant (H6c7-kras) PDEC. Glucose 37-44 interleukin 6 Homo sapiens 117-121 34064969-6 2021 Exposure to macrophages and elevated glucose levels (25 mM glucose) impacted gene expression of EMT inducers such as IL-6 and TNF-alpha as well as EMT transcription factors in benign (H6c7-pBp) and premalignant (H6c7-kras) PDEC. Glucose 59-66 interleukin 6 Homo sapiens 117-121 34064531-5 2021 The inflammatory adipocytokines, TNF-alpha, IL-1beta, and IL-6, were increased in the salt-treated Tg(+/+) WAT, but an anti-inflammation biomarker, the adiponectin/leptin ratio, was reduced in Tg(+/+), to tenth of that in Tg(-/-). Thioguanine 99-101 interleukin 6 Homo sapiens 58-62 34238029-0 2021 Metformin Antagonizes Ovarian Cancer Cells Malignancy Through MSLN Mediated IL-6/STAT3 Signaling. Metformin 0-9 interleukin 6 Homo sapiens 76-80 34074369-24 2021 SEM indicated that maternal serum IL-6 may be a mediator in the association between DII and birth weight. dilC18(3) dye 84-87 interleukin 6 Homo sapiens 34-38 34535589-9 2021 After adjusting for smoking, age, gender, race, diabetes, phosphate, and baseline calcium score, IL-6 (log) was associated with 2.2 times (95% CI: 1.1-4.6; p = 0.03) increase in death. Phosphates 58-67 interleukin 6 Homo sapiens 97-101 34535589-9 2021 After adjusting for smoking, age, gender, race, diabetes, phosphate, and baseline calcium score, IL-6 (log) was associated with 2.2 times (95% CI: 1.1-4.6; p = 0.03) increase in death. Calcium 82-89 interleukin 6 Homo sapiens 97-101 34238029-8 2021 On mechanism, metformin treatment remarkably reduced mesothelin (MSLN) expression, downregulated IL-6/STAT3 signaling activity, subsequently resulted in VEGF and TGFbeta1 expression. Metformin 14-23 interleukin 6 Homo sapiens 97-101 34238029-10 2021 CONCLUSIONS: Collectively, our findings suggested that metformin exerts anticancer effects by suppressing ovarian cancer cell malignancy, which attributed to MSLN inhibition mediated IL6/STAT3 signaling and VEGF and TGFbeta1 downregulation. Metformin 55-64 interleukin 6 Homo sapiens 183-186 34348637-6 2021 Additionally, triterpene acid mixture (ursolic acid, oleanolic acid, and betulinic acid), also isolated from rosehip, has been reported to reduce the production of interleukin-6 and Tumor necrosis factor-alpha. betulinic acid 73-87 interleukin 6 Homo sapiens 164-177 34247997-0 2021 Association of IL-6 & IL-1beta (pro-inflammatory cytokines) and related biochemical indexes in newly diagnosed diabetics subjected to glucose tolerance test. Glucose 134-141 interleukin 6 Homo sapiens 15-19 34237749-10 2021 The presence of the copper ions prevented the dramatic increase of pro-inflammatory cytokines (interleukin (IL)-6 and IL-8) and transforming growth factor beta-1 that followed skin burning. Copper 20-26 interleukin 6 Homo sapiens 95-113 35429607-5 2022 Pre-treatment with folic acid, which has known neuroprotective and anti-inflammatory properties, ameliorated IL-6 effects on mitochondrial respiration and IFN-gamma effects on dendritic spine density. Folic Acid 19-29 interleukin 6 Homo sapiens 109-113 35596974-5 2022 Furthermore, the expression level of NF-kappaB increased, unlike that of IL-6, as the concentration of linoleic acid increased. Linoleic Acid 103-116 interleukin 6 Homo sapiens 73-77 35596974-8 2022 It was also found that MCL-1, an anti-apoptotic gene known to be unaffected by IL-6, was found to be increased at the mRNA level in the linoleic acid-treated group. Linoleic Acid 136-149 interleukin 6 Homo sapiens 79-83 35452830-12 2022 CONCLUSION: CRRT with topical citrate + low-dose LMW heparin-calcium anticoagulation in the treatment of patients with SAP reduces the levels of WBC, CRP, and PCT and the concentrations of cytokines, including IL-6, IL-8, and TNF-alpha. Calcium 61-68 interleukin 6 Homo sapiens 210-214 35429607-6 2022 These findings suggest distinct mechanisms for how fetal IL-6 and IFN-gamma exposure influence risk for neuropsychiatric disorders, and how folic acid can mitigate such risk. Folic Acid 140-150 interleukin 6 Homo sapiens 57-61 35605453-10 2022 In addition, there was an increase in the serum levels of TNFalpha and IL-6 in type 2 diabetic patients and this was reversed with metformin treatment. Metformin 131-140 interleukin 6 Homo sapiens 71-75 35304817-0 2022 Tanshinone IIA-regulation of IL-6 antagonizes PM2 .5 -induced proliferation of human bronchial epithelial cells via a STAT3/miR-21 reciprocal loop. tanshinone 0-10 interleukin 6 Homo sapiens 29-33 35304817-8 2022 For HBE cells, tanshinone IIA (Tan IIA) reversed the PM2.5 -induced cell cycle alteration and cell proliferation, and reduced the expression of cytokines (IL-6, STAT3, and miR-21). tanshinone 15-29 interleukin 6 Homo sapiens 155-159 35452996-7 2022 Evaluation of the cell death phenotype revealed that glutaminolysis inhibitory treatment with CB839 or a low-glutamine medium significantly promoted the proliferation of beta-galactosidase-positive and IL-6/IL-8 secretory cells among X-irradiated tumor cells, corresponding to an increase in the senescent cell population. CB-839 94-99 interleukin 6 Homo sapiens 202-206 35533545-9 2022 The results suggested that ameliorating cisplatin-induced AKI actions of 9b was involved in downregulation of TNF-alpha, IL-1beta, IL-6, and MCP-1, inhibition of NF-kB activation, and reduction of GRPR and oxidative stress level. Cisplatin 40-49 interleukin 6 Homo sapiens 131-135 35217123-0 2022 The effects of blunt snout bream (Megalobrama amblycephala) IL-6 trans-signaling on immunity and iron metabolism via JAK/STAT3 pathway. Iron 97-101 interleukin 6 Homo sapiens 60-64 35148063-9 2022 After adjusting for other covariates, higher PM2.5-bound copper was significantly associated with increased levels of interleukin (IL)1beta, IL6, IL10, and IL17 levels. Copper 57-63 interleukin 6 Homo sapiens 141-144 35063828-2 2022 IL-6, which is one of the important cytokines, was used as a template molecule during the self-assembly polymerization strategy of dopamine. Dopamine 131-139 interleukin 6 Homo sapiens 0-4 35483198-0 2022 Changes in plasma total saturated fatty acids and palmitic acid are related to pro-inflammatory molecule IL-6 concentrations after nutritional intervention for one year. Fatty Acids 24-45 interleukin 6 Homo sapiens 105-109 35366469-13 2022 The binding of five active ingredients originated from Gancao-Banxia to IL-6-STAT3 was verified by molecular docking, namely quercetin, coniferin, licochalcone a, Licoagrocarpin and (3S,6S)-3-(benzyl)-6-(4-hydroxybenzyl)piperazine-2,5-quinone, maximizing therapeutic efficacy. coniferin 136-145 interleukin 6 Homo sapiens 72-76 35366469-13 2022 The binding of five active ingredients originated from Gancao-Banxia to IL-6-STAT3 was verified by molecular docking, namely quercetin, coniferin, licochalcone a, Licoagrocarpin and (3S,6S)-3-(benzyl)-6-(4-hydroxybenzyl)piperazine-2,5-quinone, maximizing therapeutic efficacy. licochalcone 147-159 interleukin 6 Homo sapiens 72-76 35217123-2 2022 However, the function of IL-6, especially the regulatory mechanism of IL-6 trans-signaling in immunity and iron metabolism remains largely unclear in teleost. Iron 107-111 interleukin 6 Homo sapiens 70-74 35217123-9 2022 These findings provided novel insights into IL-6 trans-signaling regulatory mechanism in teleost, enriching our knowledge of fish immunity and iron metabolism. Iron 143-147 interleukin 6 Homo sapiens 44-48 35634998-7 2022 Correlation analysis showed that IL-6 in the group with disease course >= 5 years had a positive correlation with ESR (Rs=0.438, P=0.022) and CRP (Rs=0.825, P<0.001), whereas it was negatively correlated with creatinine (Rs=-0.481, P=0.011). Creatinine 209-219 interleukin 6 Homo sapiens 33-37 35453017-10 2022 (3) based on canonical correlation analysis, the exposure to p-cymene, benzene, and styrene in PM2.5 was most likely associated with the toxicity effects (CAT, IL-6, and TNF-alpha), which in turn caused the observed toxicity. Styrene 84-91 interleukin 6 Homo sapiens 160-164 35346671-0 2022 IL-6 promotes chemoresistance via upregulating CD36 mediated fatty acids uptake in acute myeloid leukemia. Fatty Acids 61-72 interleukin 6 Homo sapiens 0-4 35346671-8 2022 Additionally, IL-6 promoted fatty acid (FA) uptake in both AML cell lines and primary AML cells. Fatty Acids 28-38 interleukin 6 Homo sapiens 14-18 35488725-4 2022 The mTOR inhibitor sirolimus, which preferentially inhibits mTORC1, has led to sustained remission in a small cohort of anti-IL-6-refractory iMCD patients with thrombocytopenia, anasarca, fever, renal dysfunction and organomegaly (iMCD-TAFRO). Sirolimus 19-28 interleukin 6 Homo sapiens 125-129 35610009-8 2022 Compared with the Model group, the dexamethasone significantly reduced the expression of p-JAK2/JAK2, p-STAT3/STAT3, and IL-6 ( < 0.01). Dexamethasone 35-48 interleukin 6 Homo sapiens 121-125 35634998-4 2022 Spearman correlation test was used to analyze the correlation of the IL-6 with C-reactive protein(CRP), erythrocyte sedimentation rate (ESR), creatinine, and cystatin C. Creatinine 142-152 interleukin 6 Homo sapiens 69-73 35435623-8 2022 RESULTS: Patients with moderate to severe cancer pain taking oxycodone had significantly higher levels of IL-2, IL-4, IL-6, IL-10, TNF-alpha, and IFN-gamma than those in the control group (p < 0.001). Oxycodone 61-70 interleukin 6 Homo sapiens 118-122 35435623-11 2022 Analgesic tolerance induced by long-term oxycodone use could be closely related to the consistent upregulation of IL-6 and TNF-alpha levels. Oxycodone 41-50 interleukin 6 Homo sapiens 114-118 35612514-0 2022 Synthesis, Antitumor of Sinomenine Derivatives and Apoptotic Induction via IL-6/PI3K/Akt/NF-kappaB Signaling Pathway in MCF-7 Cells. sinomenine 25-35 interleukin 6 Homo sapiens 76-80 35624084-8 2022 As a potential mechanism, we suggest that protoporphyrin IX and/or protoheme from Prevotella participates in hepatic injury, and that endogenous hydrogen sulfide increases serum IL-6 level in P patients. protoporphyrin IX 42-59 interleukin 6 Homo sapiens 178-182 35521772-10 2022 The concentrations of follicular IL-6, IL-8 and mature IL-18 were significantly higher in PCOS group and were positively correlated with the levels of fatty acids. Fatty Acids 151-162 interleukin 6 Homo sapiens 33-37 35604216-6 2022 Here, we show that this Bartha-induced pDC hyperactivation extends to other important cytokines, including interleukin-12/23 (IL-12/23) and tumor necrosis factor alpha (TNF-alpha) but not IL-6. bartha 24-30 interleukin 6 Homo sapiens 188-192 35098302-0 2022 The Interleukin-6 trans-signaling promotes progesterone production in human granulosa-lutein cells. Progesterone 43-55 interleukin 6 Homo sapiens 4-17 35098302-3 2022 Moreover, the detailed molecular mechanisms by which IL-6 regulates the production of progesterone in human granulosa cells remain to be elucidated. Progesterone 86-98 interleukin 6 Homo sapiens 53-57 35098302-4 2022 In the present study, we used primary and immortalized human granulosa-lutein (hGL) cells to investigate the effects of IL-6 on progesterone synthesis and the underlying molecular mechanisms. Progesterone 128-140 interleukin 6 Homo sapiens 120-124 35098302-5 2022 We found that IL-6 trans-signaling by the combined addition of IL-6 and soluble IL-6 receptor (sIL-6Ralpha) induced StAR expression and progesterone production in hGL cells. Progesterone 136-148 interleukin 6 Homo sapiens 14-18 35098302-5 2022 We found that IL-6 trans-signaling by the combined addition of IL-6 and soluble IL-6 receptor (sIL-6Ralpha) induced StAR expression and progesterone production in hGL cells. Progesterone 136-148 interleukin 6 Homo sapiens 63-67 35620570-3 2022 Results: The empagliflozin-metformin combination increased levels of the antioxidants (TAS, SOD, and GPx up to 1.1-fold; P < 0.01), decreased the levels of prooxidants (AOPP and isoprostanes up to 1.2-fold, P < 0.01; AGE up to 1.5-fold, P < 0.01), and decreased inflammatory parameters (up to 1.5-fold, CRP P < 0.01; IL-6 P < 0.001). Metformin 27-36 interleukin 6 Homo sapiens 317-321 35628356-8 2022 These results suggested that inhibiting a vicious cycle of the ROS/STAT3/IL-6 axis by ASC-J9 may represent a potential therapeutic approach to suppress cell proliferation and ECM production in KFs. ros 63-66 interleukin 6 Homo sapiens 73-77 35574627-8 2022 Also, curcumin supplementation elicited significant improvements in MVC (WMD = 3.10 nm, 95% CI (1.45-4.75)) and ROM (WMD = 6.49 , 95% CI (3.91-9.07)), although no significant changes in IL-6 and IL-8 levels were found. Curcumin 6-14 interleukin 6 Homo sapiens 186-190 35536531-4 2022 Tofacitinib significantly inhibited expression of pro-inflammatory factors including tumor necrosis factor-alpha (TNF-alpha), vascular endothelial growth factor A, matrix metalloproteinase 1, matrix metalloproteinase 3, interleukin-6 and interferon gamma in RA-FLS cells. tofacitinib 0-11 interleukin 6 Homo sapiens 220-233 35605724-10 2022 Copper exposure stimulated 16HBE cells to release proinflammatory IL-6 and IL-8. Copper 0-6 interleukin 6 Homo sapiens 66-70 35583799-7 2022 In addition, we found that inhibition of AL137857.1 suppressed the expression of a series of inflammatory cytokines, including IL-1, IL-6, TNF-alpha, Cox2 and iNOS. al137857 41-49 interleukin 6 Homo sapiens 133-137 35631449-0 2022 Tofacitinib May Inhibit Myofibroblast Differentiation from Rheumatoid-Fibroblast-like Synoviocytes Induced by TGF-beta and IL-6. tofacitinib 0-11 interleukin 6 Homo sapiens 123-127 35512641-6 2022 The relationship between malnutrition and inflammation is highlighted by the correlation of serum cholesterol levels with serum alpha-1 acid glycoprotein and IL-6 levels (r = -0.56, r = -0.39, respectively; p < 0.05). Cholesterol 98-109 interleukin 6 Homo sapiens 158-162 35286922-1 2022 We have recently highlighting the role of spiroisoxazoline arteannuin B derivatives in mediating proinflammatory cytokines like IL-6, TNfalpha and NO in vitro. arteannuin B 59-71 interleukin 6 Homo sapiens 128-132 35525835-12 2022 CONCLUSIONS: PMX-DHP combined with steroid pulse therapy might reduce GRO, IL-10, IL-1Ra, IL-5, IL-6, and MCP-1 levels in ARF, contributing to better oxygenation in the disorder. Steroids 35-42 interleukin 6 Homo sapiens 96-100 35379924-12 2022 These results indicated that 27-hydroxycholesterol linked high cholesterol and LAC metastasis by regulating NFkappaB/PPIB axis and the secretion of FGF2 and IL-6. Cholesterol 63-74 interleukin 6 Homo sapiens 157-161 35429917-10 2022 Urinary copper (Cu) and selenium (Se) was statistically associated with IL-6 (88.10%, 95%CI: 34.92, 162.24) and tumor necrosis factor-alpha (TNF-alpha) (22.32%, 95%CI: 3.28, 44.12), respectively. Copper 8-14 interleukin 6 Homo sapiens 72-76 35429917-10 2022 Urinary copper (Cu) and selenium (Se) was statistically associated with IL-6 (88.10%, 95%CI: 34.92, 162.24) and tumor necrosis factor-alpha (TNF-alpha) (22.32%, 95%CI: 3.28, 44.12), respectively. Copper 16-18 interleukin 6 Homo sapiens 72-76 35323077-7 2022 RESULTS: Relative to thermoneutral water immersion, hot water immersion increased core temperature (+1.66 C (+1.47, +1.87), P<0.01), heart rate (+34 bpm (+24, +44), P<0.01), antegrade shear rate (+96 s-1 (+57, +134), P<0.01), and IL-6 (+1.38 pg/mL (+0.31, +2.45), P=0.01). Water 56-61 interleukin 6 Homo sapiens 230-234 35289351-11 2022 In-vitro studies revealed that nicotine lowers the expression of inflammatory cytokines (TNF, IL6, IL1beta) and proteins (TRAF2, P50, P65) at 1 microg/ml in TNFalpha induced SW982 cells.Nicotine from natural sources (Brassica oleracea) has been found to be an effective anti- inflammatory compound at a low dosage. Nicotine 31-39 interleukin 6 Homo sapiens 94-97 35571122-9 2022 Both mycophenolic acid and rapamycin inhibited inflammatory and fibrotic processes induced by TGF-beta1 or IL-6 by downregulating mTOR and ERK phosphorylation. Sirolimus 27-36 interleukin 6 Homo sapiens 107-111 35624727-6 2022 In a dose-dependent manner, concomitant administration of kinetin with cisplatin significantly restored testicular oxidative stress parameters, corrected the distorted sperm quality parameters and histopathological changes, enhanced levels of serum testosterone and testicular StAR protein expression, as well as reduced the up-regulation of testicular TNF-alpha, IL-1beta, Il-6, and caspase-3, caused by cisplatin. Cisplatin 71-80 interleukin 6 Homo sapiens 374-378 35563797-9 2022 Six months after completion of the BPA treatment, there was a decrease in concentrations of IL-6 ( = -1.61 (-3.11; -0.20); p = 0.03), of IL8 ( = -3.24 (-7.72; 0.82); p = 0.01), and of ET-1 ( = -0.47 (-0.96; 0.05); p = 0.005). bisphenol A 35-38 interleukin 6 Homo sapiens 92-96 35529915-7 2022 The patients given Breztri Aerosphere showed significantly lower levels of pulmonary vascular resistance (PVR), mean pulmonary arterial pressure (MAPA), pulmonary artery wedge pressure (PAWP), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-alpha), and procalcitonin (PCT) versus those receiving conventional treatment. breztri 19-26 interleukin 6 Homo sapiens 193-206 35529915-7 2022 The patients given Breztri Aerosphere showed significantly lower levels of pulmonary vascular resistance (PVR), mean pulmonary arterial pressure (MAPA), pulmonary artery wedge pressure (PAWP), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-alpha), and procalcitonin (PCT) versus those receiving conventional treatment. breztri 19-26 interleukin 6 Homo sapiens 208-212 35478259-5 2022 IL-6 values were higher in patients in SA, in AD, in those receiving steroids alone, and in patients without CR or LDAS (p < 0.05). Steroids 69-77 interleukin 6 Homo sapiens 0-4 35565270-0 2022 Resveratrol Contrasts IL-6 Pro-Growth Effects and Promotes Autophagy-Mediated Cancer Cell Dormancy in 3D Ovarian Cancer: Role of miR-1305 and of Its Target ARH-I. Resveratrol 0-11 interleukin 6 Homo sapiens 22-26 35625746-5 2022 Markers of inflammation, such as C-reactive protein, tumor-necrosis-factor alpha, and interleukin 6, provide insight into the disease and markers that negatively influence nitric-oxide bioavailability and promote oxidative stress. Nitric Oxide 172-184 interleukin 6 Homo sapiens 86-99 35565270-5 2022 IL-6 disrupts autophagy in ovarian cancer cells via miRNAs downregulation of ARH-I, an effect contrasted by the nutraceutical protein restriction mimetic resveratrol (RV). Resveratrol 154-165 interleukin 6 Homo sapiens 0-4 35565270-5 2022 IL-6 disrupts autophagy in ovarian cancer cells via miRNAs downregulation of ARH-I, an effect contrasted by the nutraceutical protein restriction mimetic resveratrol (RV). Resveratrol 167-169 interleukin 6 Homo sapiens 0-4 35445688-4 2022 RESULTS: Compared to continuing-gens, first-gens had greater systemic inflammation (composite of averaged z-scores for C-reactive protein and interleukin-6; B = 0.515, SE = 0.171, p = .003) during the fall but not spring semester (p > .05). gens 44-48 interleukin 6 Homo sapiens 142-155 35460571-6 2022 Cytokines, such as TNF-alpha, INF-gamma, IL-6, and IL-13, were upregulated in infected cells sparking mitochondrial ROS production and change in electron transport chain complexes. ros 116-119 interleukin 6 Homo sapiens 41-45 35529881-6 2022 Serum IFN-gamma and IL-6 levels were decreased in steroid-treated patients when compared to non-steroid treated patients. Steroids 50-57 interleukin 6 Homo sapiens 20-24 35529881-6 2022 Serum IFN-gamma and IL-6 levels were decreased in steroid-treated patients when compared to non-steroid treated patients. Steroids 96-103 interleukin 6 Homo sapiens 20-24 35448938-6 2022 In our results, the three SCFAs could inhibit ROS expressions, NLRP3, Caspase-1, IL-1beta, IL-6, IL-18, Beclin-1 and LC3-II, when induced by 5-FU. Fluorouracil 141-145 interleukin 6 Homo sapiens 91-95 35443035-7 2022 Moreover, ATP and ADP were significantly positively correlated with the Positive and Negative Symptom Scale (PANSS) item "lack of judgment and insight"; IL-1beta, IL-12 and TNF-alpha were significantly positively correlated with "tension" and "depression"; and "disorientation" and "poor attention" were correlated significantly with IL-6 and IL-8. Adenosine Triphosphate 10-13 interleukin 6 Homo sapiens 334-338 35441257-2 2022 Nicotine has been shown to stimulate the production of cytokines that are priming agents for inflammation that induces tissue destruction, such as IL-1beta, IL-6, and IL-8, by gingival keratinocytes and human gingival fibroblasts (HGF). Nicotine 0-8 interleukin 6 Homo sapiens 157-161 35441257-8 2022 Nicotine elevated the expression of pro-inflammatory cytokines TNF-alpha, IL-1beta, IL-6, IL-8, and IL-17 and decreased the anti-inflammatory IL-10 in HGFs at 24 and 72 h. Boric acid at 100 ng/mL in the medium prevented the changes induced by nicotine alone. Nicotine 0-8 interleukin 6 Homo sapiens 84-88 35443035-7 2022 Moreover, ATP and ADP were significantly positively correlated with the Positive and Negative Symptom Scale (PANSS) item "lack of judgment and insight"; IL-1beta, IL-12 and TNF-alpha were significantly positively correlated with "tension" and "depression"; and "disorientation" and "poor attention" were correlated significantly with IL-6 and IL-8. Adenosine Diphosphate 18-21 interleukin 6 Homo sapiens 334-338 35429212-4 2022 Here, we demonstrate that both IL-6 classic signaling and trans-signaling depend on membrane cholesterol, an essential raft component. Cholesterol 93-104 interleukin 6 Homo sapiens 31-35 35462520-2 2022 In addition, a high carbohydrate diet can increase liver metabolic burden, increase mitochondrial oxidative phosphorylation, leading to oxidative stress, generate new fat during adenosine triphosphate synthesis, and thus resulting in ectopic fat accumulation, which further activate nuclear factor-kappaB signaling pathway and release inflam- matory factors such as tumor necrosis factor-alpha, interleukin-1beta (IL-1beta), IL-6, and so on. Carbohydrates 20-32 interleukin 6 Homo sapiens 425-429 35563682-5 2022 Following preconditioning, both Rapa and 3-MA-treated hASCs demonstrated preservation of stemness, as well as upregulated transcription of cyclooxygenase-2 (COX2) and interleukin-6 (IL-6). Sirolimus 32-36 interleukin 6 Homo sapiens 167-180 35563682-5 2022 Following preconditioning, both Rapa and 3-MA-treated hASCs demonstrated preservation of stemness, as well as upregulated transcription of cyclooxygenase-2 (COX2) and interleukin-6 (IL-6). Sirolimus 32-36 interleukin 6 Homo sapiens 182-186 35563682-5 2022 Following preconditioning, both Rapa and 3-MA-treated hASCs demonstrated preservation of stemness, as well as upregulated transcription of cyclooxygenase-2 (COX2) and interleukin-6 (IL-6). 3-methyladenine 41-45 interleukin 6 Homo sapiens 167-180 35563682-5 2022 Following preconditioning, both Rapa and 3-MA-treated hASCs demonstrated preservation of stemness, as well as upregulated transcription of cyclooxygenase-2 (COX2) and interleukin-6 (IL-6). 3-methyladenine 41-45 interleukin 6 Homo sapiens 182-186 35563682-8 2022 Rapa-pretreated cells, but not 3-MA-pretreated cells, further amplified COX2 and IL-6 transcripts following IFNgamma exposure, and both groups upregulated secretion of prostaglandin-E2 (PGE2), the enzymatic product of COX2. Sirolimus 0-4 interleukin 6 Homo sapiens 81-85 35625671-9 2022 The expression levels of CD33+ leukocytes and circulating IL-6 were higher (p < 0.05) among patients with arterial oxygen partial pressure-to-fractional inspired oxygen (PaO2/FiO2) ratios below 13.3 kPa compared to in the remaining patients. Oxygen 115-121 interleukin 6 Homo sapiens 58-62 35625671-9 2022 The expression levels of CD33+ leukocytes and circulating IL-6 were higher (p < 0.05) among patients with arterial oxygen partial pressure-to-fractional inspired oxygen (PaO2/FiO2) ratios below 13.3 kPa compared to in the remaining patients. Oxygen 162-168 interleukin 6 Homo sapiens 58-62 35429212-5 2022 Super-resolution fluorescence imaging using perfringolysin O D4 fragments that selectively bind to high cholesterol concentrations revealed that IL-6 and hyper IL-6, a fusion protein of IL-6 and soluble IL-6Ralpha, induce the alteration of membrane rafts. Cholesterol 104-115 interleukin 6 Homo sapiens 145-149 35429212-5 2022 Super-resolution fluorescence imaging using perfringolysin O D4 fragments that selectively bind to high cholesterol concentrations revealed that IL-6 and hyper IL-6, a fusion protein of IL-6 and soluble IL-6Ralpha, induce the alteration of membrane rafts. Cholesterol 104-115 interleukin 6 Homo sapiens 160-164 35292250-8 2022 Overall, peptides of VTPY and VLLY possessed outstanding capacity to induce the proliferation and migration of HSF cells and HUVEC cells in vitro and the mechanism was mainly related to improving mitochondrial respiratory capacity to produce more ATP for biological energy, blocking the binding of MKP to ERK2 and PHLPP to AKT and thus upregulating the ERK/AKT pathway. Adenosine Triphosphate 247-250 interleukin 6 Homo sapiens 111-114 35428182-12 2022 Furthermore, ropivacaine contributed to the release of pro-inflammatory cytokines (IL-6 and TNF-alpha) and inhibited the secretion of anti-inflammatory cytokines of keratinocytes (IL-10). Ropivacaine 13-24 interleukin 6 Homo sapiens 83-87 35498027-7 2022 Results: Tanshinone IIA reduced the serum levels of C-reactive protein (CRP), interleukin (IL)-1beta, IL-6, and P-selectin in KD patients; such inhibitory effect was more significant compared to aspirin and IVIG. tanshinone 9-23 interleukin 6 Homo sapiens 102-106 35493463-8 2022 TRP score was positively associated with malignant pathways in pan-cancer, such as IL6-JAK-STAT3 signalling, interferon-gamma response, and inflammatory response. Tryptophan 0-3 interleukin 6 Homo sapiens 83-86 35498037-14 2022 Finally, in human cardio myocytes, we observed 5-FU-induced upregulation of the inflammatory, senescence-associated cytokine IL6 and p16 genes, which expression was reduced by OMWW treatment. Fluorouracil 47-51 interleukin 6 Homo sapiens 125-128 35457130-4 2022 As IL-6 and EGF signaling are growth and inflammatory-inducible responses, we examined if glucose challenge can increase STAT3 activation, promoting adaptive changes in XRCC1 expression in different cell types. Glucose 90-97 interleukin 6 Homo sapiens 3-7 35450396-4 2022 During the research, the curcumin effect was evaluated by measuring cell survivability, expression of MMP1 gene, subcellular localization of P70S6K1 protein, and its phosphorylated form and amount of produced IL-6 and TNF-alpha. Curcumin 25-33 interleukin 6 Homo sapiens 209-213 35385924-2 2022 One of the main causes of AoC is cancer-associated inflammation that activates mechanisms, commonly observed in anemia of inflammation, where functional iron deficiency and iron-restricted erythropoiesis is induced by increased hepcidin levels in response to IL-6 elevation. Iron 173-177 interleukin 6 Homo sapiens 259-263 35479493-8 2022 Elevated serum IL-6 levels were associated with increased Glx levels in left HPC, left MTC, and right DLPFC, after processing the 1H-MRS data with Tarquin. Hydrogen 130-132 interleukin 6 Homo sapiens 15-19 35453772-9 2022 CONCLUSIONS: curcumin and piperine supplementation had no effect on physical performance, immune cell counts, or muscle damage; however, the supplementation could modulate the kinetics of IL-2, TNF-alpha, INF, IL-6, and IL-10 1 h after the end of exercise. Curcumin 13-21 interleukin 6 Homo sapiens 210-214 35400331-8 2022 RESULTS: Excess sucrose significantly enhanced inflammatory signal molecules (e.g., IL-1beta, IL-6, CCL2) secretion, concomitant with the enhancement of intracellular triglycerides in co-cultured HepG2 cells. Triglycerides 167-180 interleukin 6 Homo sapiens 94-98 35432729-5 2022 Furthermore, the oxygen-glucose deprivation/reoxygenation (OGD/R) model was used to validate the anti-inflammatory effects of the key ingredients by determining the levels of inflammatory cytokines, including interleukin (IL)-6, IL-1beta, and tumor necrosis factor (TNF)-alpha. Glucose 24-31 interleukin 6 Homo sapiens 209-227 35462936-7 2022 Furthermore, the secretion of inflammatory cytokines (IL-1beta, IL-18, IL-6, and TNF-alpha) activation of NLRP3 inflammasome and NF-kappaB signaling pathway were markedly suppressed by EC in vitro and in vivo. Catechin 185-187 interleukin 6 Homo sapiens 71-75 35455444-7 2022 H2O2 reduced the cells" viability and increased the expression of the pro-inflammatory markers NF-kappaB, IL-6, IL-1beta, and TNF-alpha; by contrast, it decreased the expression of the anti-inflammatory IL-10. Hydrogen Peroxide 0-4 interleukin 6 Homo sapiens 106-110 35218740-10 2022 Taken together, the present study indicates that CORM-2-induced Nrf2/HO-1 alleviates IL-6/Jak2/Stat3-mediated inflammatory responses to Ang II by inhibiting NADPH oxidase- and mitochondria-derived ROS, suggesting that CORM-2 is a promising pharmacologic candidate to reverse the pathological changes involved in the inflammation of vessel wall for the prevention and treatment of AAA. ros 197-200 interleukin 6 Homo sapiens 85-89 35450316-7 2022 Results: BG brought out the increased gene and protein expression of inflammatory biomarkers such as interleukin (IL)-1beta, IL-6, IL-8, and tumor necrosis factor-alpha, in the LPS-treated sebocytes and ORS cells. O(6)-benzylguanine 9-11 interleukin 6 Homo sapiens 125-129 35218740-0 2022 Carbon monoxide releasing molecule-2 attenuates angiotensin II-induced IL-6/Jak2/Stat3-associated inflammation by inhibiting NADPH oxidase- and mitochondria-derived ROS in human aortic smooth muscle cells. ros 165-168 interleukin 6 Homo sapiens 71-75 35366783-7 2022 In COVID-19 patients, aspirin can reduce CRP, IL-6 levels, and platelet aggregation by inhibiting thromboxane A2. Aspirin 22-29 interleukin 6 Homo sapiens 46-50 35218740-6 2022 The results showed that Ang II induced inflammatory responses of HASMCs via NADPH oxidase- and mitochondria-derived ROS/NF-kappaB/IL-6/Jak2/Stat3 pathway which was attenuated by the pretreatment with CORM-2. ros 116-119 interleukin 6 Homo sapiens 130-134 35612375-4 2022 In this study, we found that pro-inflammatory cytokines-IL-1beta, IL-6 and TNFalpha showed greater induction in phorbol-12-myristate-13-acetate (PMA)-differentiated THP-1 cells than in THP-1 cells. Tetradecanoylphorbol Acetate 112-143 interleukin 6 Homo sapiens 66-70 35432339-8 2022 We identified increased gene expression of specific pro-inflammatory cytokines (Il-6, Il-1beta, Il-12) when O-GlcNAc cycling was blocked. o-glcnac 108-116 interleukin 6 Homo sapiens 80-84 35432339-11 2022 Further, elevated O-GlcNAc acted on Il-6 expression through the iNOS pathway, as iNOS inhibitior L-NIL raised wildtype Il-6 expression similar to OGA deficient cells but had no further effect on the hyper-O-GlcNAcylated cells. o-glcnac 18-26 interleukin 6 Homo sapiens 36-40 35432339-11 2022 Further, elevated O-GlcNAc acted on Il-6 expression through the iNOS pathway, as iNOS inhibitior L-NIL raised wildtype Il-6 expression similar to OGA deficient cells but had no further effect on the hyper-O-GlcNAcylated cells. o-glcnac 18-26 interleukin 6 Homo sapiens 119-123 35612375-4 2022 In this study, we found that pro-inflammatory cytokines-IL-1beta, IL-6 and TNFalpha showed greater induction in phorbol-12-myristate-13-acetate (PMA)-differentiated THP-1 cells than in THP-1 cells. Tetradecanoylphorbol Acetate 145-148 interleukin 6 Homo sapiens 66-70 35362514-8 2022 IL-1beta and IL-6 were up-regulated after 1h, but IL-1beta decreased right after 3h, while IL-6 sustained up-regulation throughout all time points. Hydrogen 42-44 interleukin 6 Homo sapiens 13-17 35152538-11 2022 Finally, ethanol induced hepatocellular steatosis, SREBP1 transcription, and modulated the expression of SREBP1c, ACAC, ACLY, FASN, IL-1beta, IL-6, TNF-alpha, GPC3, FLNB and p53. Ethanol 9-16 interleukin 6 Homo sapiens 142-146 35443443-14 2022 A weak negative correlation of IL-1 and TNF-alpha was seen with vitamin D in diabetics without nephropathy, whereas IL-6 had a weak negative correlation with vitamin D in diabetics with nephropathy. Vitamin D 158-167 interleukin 6 Homo sapiens 116-120 34677149-9 2022 The rectal ozone protocol is rectal ozone insufflation, resulting in clinical improvement in oxygen saturation and biochemical improvement (fibrinogen, D-dimer, urea, ferritin, LDH, interleukin-6, and C-reactive protein). Ozone 11-16 interleukin 6 Homo sapiens 182-195 34677149-9 2022 The rectal ozone protocol is rectal ozone insufflation, resulting in clinical improvement in oxygen saturation and biochemical improvement (fibrinogen, D-dimer, urea, ferritin, LDH, interleukin-6, and C-reactive protein). Ozone 36-41 interleukin 6 Homo sapiens 182-195 35401926-6 2022 COS treatment significantly increased levels of the TGF-beta1 and IL-10 proteins and decreased levels of the IL-6 protein. carbonyl sulfide 0-3 interleukin 6 Homo sapiens 109-113 35101812-13 2022 CONCLUSIONS: The ratio of arachidonic acid to eicosopentaenoic acid, and omega-3 PUFAs, can be systemic signs of poor prognosis, increased lung damage, and high mortality in COVID-19, together with IL-6. Arachidonic Acid 26-42 interleukin 6 Homo sapiens 198-202 34989171-10 2022 In addition, the serum inflammation factors (CRP, IL6, and TNF-alpha) were significantly reduced by vitamin D supplementation. Vitamin D 100-109 interleukin 6 Homo sapiens 50-53 35454970-8 2022 In addition, inhibition of interleukin (IL)-6 with dexamethasone, tocilizumab, and sarilumab effectively treats cytokine storm and significantly reduces mortality caused by COVID-19. Dexamethasone 51-64 interleukin 6 Homo sapiens 27-45 35531217-5 2022 The observed viability in nicotine treated cells were due to elevated IL-6, IL-10 while in glucose was due to brain derived neurotropic factor (BDNF). Nicotine 26-34 interleukin 6 Homo sapiens 70-74 35362396-3 2022 METHODS: The in-vitro enzyme inhibitory activity of saccharumoside-B on PLA2, COX-1, COX-2, and 5-LOX enzymes were evaluated by the cell-free method, its effect on TNF-alpha, IL-1beta, and IL-6 secretion levels in LPS stimulated THP-1 human monocytes was determined by ELISA based methods. Saccharumoside B 52-68 interleukin 6 Homo sapiens 189-193 35433741-11 2022 Meanwhile, the enhanced protein levels of Bax, cleaved caspase-3/caspase-3 ratio, levels of Pp-65/p-65, levels of IL-6, and the production of ROS induced by cisplatin were significantly attenuated by ISL treatment. Cisplatin 157-166 interleukin 6 Homo sapiens 114-118 35301059-10 2022 Moreover, we found that cadmium exposure induces the pro-inflammatory state of the adipocytes by enhancing the expression of genes such as IL-6, IL-1B and CCL2, cytokines also induced in obesity. Cadmium 24-31 interleukin 6 Homo sapiens 139-143 35212163-3 2022 We initially found that the glycolytic inhibitor 2-deoxy-d-glucose (2-DG), a simple monosaccharide, attenuated cellular responses to IL-6 by inhibiting N-linked glycosylation of the IL-6 receptor gp130. Glucose 59-66 interleukin 6 Homo sapiens 182-186 35212163-3 2022 We initially found that the glycolytic inhibitor 2-deoxy-d-glucose (2-DG), a simple monosaccharide, attenuated cellular responses to IL-6 by inhibiting N-linked glycosylation of the IL-6 receptor gp130. Nitrogen 152-153 interleukin 6 Homo sapiens 182-186 35431945-10 2022 QGHXR, QGR, and HXR groups mainly reduced the serum TG level and the expression of inflammatory factors such as IL-6 and TNF-alpha in the liver induced by ethanol. Ethanol 155-162 interleukin 6 Homo sapiens 112-116 35406728-5 2022 Additionally, the sex-biased phenotype of certain cancers (e.g., hepatocellular carcinoma (HCC) which is 3-5-fold more common in men) was related to the inhibition of macrophage-derived IL-6 production by estradiol-17beta (E2). Estradiol 205-221 interleukin 6 Homo sapiens 186-190 35406728-5 2022 Additionally, the sex-biased phenotype of certain cancers (e.g., hepatocellular carcinoma (HCC) which is 3-5-fold more common in men) was related to the inhibition of macrophage-derived IL-6 production by estradiol-17beta (E2). Estradiol 223-225 interleukin 6 Homo sapiens 186-190 35338162-11 2022 The high alcohol pattern was associated with high concentrations of circulating concentrations of pro-inflammatory markers (CRP, IL-6, VEGF). Alcohols 9-16 interleukin 6 Homo sapiens 129-133 35466217-6 2022 Further ex vivo and in vitro experiments revealed that ZnONPs enhanced the migration of PMNs, promoted their bacterial phagocytosis efficiency, proinflammatory cytokine (TNF-alpha, IL-1beta, and IL-6) expression, and reactive oxygen species (ROS) production. znonps 55-61 interleukin 6 Homo sapiens 195-199 35368752-10 2022 Puerarin and paeoniflorin exerted anti-inflammatory effects by decreasing production of MDC/CCL22 and IL-6 in TI-treated HaCaT cells and VEGF production in SP/CRH-stimulated HMC-1 cells. puerarin 0-8 interleukin 6 Homo sapiens 102-106 35233569-7 2022 Mito-MES reduced production of IL-6 by SARS-CoV-2 infected epithelial cells through its antioxidant properties (Nrf2 agonist, coenzyme Q 10 moiety) and the dTPP moiety. coenzyme Q10 126-139 interleukin 6 Homo sapiens 31-35 35322136-4 2022 In the present study, we characterize the production, processing and release of the pro-inflammatory cytokines IL-1beta and IL-6 from PBMC of MD (n = 14) patients in response to sodium chloride (NaCl), and determined the effect of the diuretic triamterene-hydrocholothiazide (T-HCTZ), or anakinra in these patients. Sodium Chloride 178-193 interleukin 6 Homo sapiens 124-128 35322136-4 2022 In the present study, we characterize the production, processing and release of the pro-inflammatory cytokines IL-1beta and IL-6 from PBMC of MD (n = 14) patients in response to sodium chloride (NaCl), and determined the effect of the diuretic triamterene-hydrocholothiazide (T-HCTZ), or anakinra in these patients. Sodium Chloride 195-199 interleukin 6 Homo sapiens 124-128 35371061-0 2022 Inhibition of Histone H3 Lysine-27 Demethylase Activity Relieves Rheumatoid Arthritis Symptoms via Repression of IL6 Transcription in Macrophages. Lysine 25-31 interleukin 6 Homo sapiens 113-116 35356749-0 2022 circRNA_101277 Influences Cisplatin Resistance of Colorectal Cancer Cells by Modulating the miR-370/IL-6 Axis. Cisplatin 26-35 interleukin 6 Homo sapiens 100-104 35258919-3 2022 Here, we developed a novel Lys-AuNPs@MoS2 nanocomposite self-assembled microfluidic immunoassay biochip with digital signal output and applied it to the simultaneous detection of multiple serum biomarkers including inflammatory factors and cardiovascular biomarkers, PCT, CRP, IL6, cTnI, cTnT, and NT-BNP, with high throughput and sensitivity. Lysine 27-30 interleukin 6 Homo sapiens 277-280 35303193-6 2022 Foam cells were treated with pre-degraded PLLA powder, curcumin and PPARgamma inhibitor GW9662, and the expression of IL-6, IL-10, TNF-alpha, NF-kappab, PLA2 and PPARgamma were investigated by ELISA or RT-qPCR. Curcumin 55-63 interleukin 6 Homo sapiens 118-122 35356749-11 2022 At a mechanistic level, circRNA_101277 was found to function by sequestering miR-370, thereby upregulating the miR-370 target gene IL-6 and promoting cisplatin resistance via this miR-370/IL-6 axis. Cisplatin 150-159 interleukin 6 Homo sapiens 188-192 35356749-12 2022 Conclusion: In summary, our data highlight circRNA_101277 as a novel driver of CRC cell cisplatin resistance that functions by sequestering miR-370 and thereby enhancing IL-6 expression. Cisplatin 88-97 interleukin 6 Homo sapiens 170-174 35261309-11 2022 Conclusion: Prior supplementation of the combination of vitamins C and E attenuates OS (lipid peroxidation), the inflammatory response (interleukin-6), cortisol levels, and muscle damage (creatine kinase) following a session of exercise. Carbon 65-66 interleukin 6 Homo sapiens 136-149 35356738-0 2022 Corrigendum: Effects of Vitamin D and K on Interleukin-6 in COVID-19. Vitamin D 24-33 interleukin 6 Homo sapiens 43-56 35264090-3 2022 Unlike what is observed in inflammation, IL-6 produced by skeletal muscle is not preceded by the release of other pro-inflammatory cytokines, but is seems to be dependent on the lactate produced during exercise, thus causing different effects from those of seen in inflammatory state. Lactic Acid 178-185 interleukin 6 Homo sapiens 41-45 35264090-6 2022 IL-6 increases GLUT-4 vesicle mobilization to muscle cell periphery, increasing the glucose transport into the cell, and also glycogen synthesis. Glucose 84-91 interleukin 6 Homo sapiens 0-4 35264617-7 2022 Cd increased the percentage of apoptotic cells and decreased cell viability and IL-6 production. Cadmium 0-2 interleukin 6 Homo sapiens 80-84 35433995-13 2022 Both doses of ASA + CPG decreased pro-inflammatory cytokine interleukin (IL)-6 expression 21 days after stroke. Aspirin 14-17 interleukin 6 Homo sapiens 60-78 35236262-5 2022 The co-activation of toll-like receptors 4 (TLR4) by lipopolysaccharide, a constituent of the cell membrane of gram negative bacteria, and the P2X7R by ATP leads to the generation and release of the pro-inflammatory cytokines interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha. Adenosine Triphosphate 152-155 interleukin 6 Homo sapiens 256-260 35433995-14 2022 Taken together, these results demonstrated that combination treatment with ASA + CPG improved long-term neurological function after stroke and may inhibit platelet-neutrophil interaction by decreasing the concentration of pro-inflammatory cytokine, IL-6. Aspirin 75-78 interleukin 6 Homo sapiens 249-253 35051728-9 2022 Direct correlations between leptin and fat mass, TNF and IL-6 with creatinine and pre-dialysis urea were observed in all time-points (1, 6 and 12 months). Creatinine 67-77 interleukin 6 Homo sapiens 57-61 35051728-11 2022 Fat mass, creatinine and pre-dialysis urea were predictive markers of leptin, TNF, IL-6 and IL-10 variability. Urea 38-42 interleukin 6 Homo sapiens 83-87 35043090-7 2022 Although dipeptidyl peptidase-4 plays an important role in glucose homeostasis, additionally it also stimulates the production of proinflammatory cytokines such as IL-6 and TNF-alpha creating a cytokine storm. Glucose 59-66 interleukin 6 Homo sapiens 164-168 35104780-8 2022 Collectively, our results demonstrated that DoPE inhibited IL-6 expression by reducing ROS generation, suppressing ERK phosphorylation, and inhibiting translocation of NF-kB p65 and NF-kB activity in PM10-stimulated HaCaT cells, suggesting that DoPE can be useful for the resolution of the inflammation caused by IL-6. Reactive Oxygen Species 87-90 interleukin 6 Homo sapiens 59-63 35126722-7 2022 Previous studies have reported the anti-inflammatory effect of melatonin by adjusting levels of pro-inflammatory cytokines, including interleukin (IL)-6, IL-1beta and tumor necrosis factor-alpha. Melatonin 63-72 interleukin 6 Homo sapiens 134-152 35126722-8 2022 Melatonin treatment has been demonstrated to decrease IL-6 and IL-10 expression levels and efficiently attenuate T-cell proliferation. Melatonin 0-9 interleukin 6 Homo sapiens 54-58 35104780-0 2022 The DPA-derivative 11S, 17S-dihydroxy 7,9,13,15,19 (Z,E,Z,E,Z)-docosapentaenoic acid inhibits IL-6 production by inhibiting ROS production and ERK/NF-kappaB pathway in keratinocytes HaCaT stimulated with a fine dust PM10. Reactive Oxygen Species 124-127 interleukin 6 Homo sapiens 94-98 35014680-8 2022 GSEA identified the IL-6/JAK/STAT3 pathway as a potential downstream signalling pathway of TGM2. gsea 0-4 interleukin 6 Homo sapiens 20-24 35237386-11 2022 The cutoff value of IL-6 for in-hospital death prediction was 74.98 pg/mL (Sn 69.7%, Sp 62.7%); cutoff value of CRP was 81 mg/L (Sn 60.7%, Sp 60%); cutoff value of procalcitonin was 0.56 ng/mL (Sn 81.1%, Sp 76%); and cutoff value of D-dimer was 760 ng/mL FEU (Sn 63.4%, Sp 57.1%). TFF2 protein, human 85-87 interleukin 6 Homo sapiens 20-24 35237386-11 2022 The cutoff value of IL-6 for in-hospital death prediction was 74.98 pg/mL (Sn 69.7%, Sp 62.7%); cutoff value of CRP was 81 mg/L (Sn 60.7%, Sp 60%); cutoff value of procalcitonin was 0.56 ng/mL (Sn 81.1%, Sp 76%); and cutoff value of D-dimer was 760 ng/mL FEU (Sn 63.4%, Sp 57.1%). TFF2 protein, human 204-206 interleukin 6 Homo sapiens 20-24 35237386-11 2022 The cutoff value of IL-6 for in-hospital death prediction was 74.98 pg/mL (Sn 69.7%, Sp 62.7%); cutoff value of CRP was 81 mg/L (Sn 60.7%, Sp 60%); cutoff value of procalcitonin was 0.56 ng/mL (Sn 81.1%, Sp 76%); and cutoff value of D-dimer was 760 ng/mL FEU (Sn 63.4%, Sp 57.1%). TFF2 protein, human 270-272 interleukin 6 Homo sapiens 20-24 35220312-6 2022 RESULTS: After the intervention, the combination of propolis and melatonin significantly reduced interleukin-6 (-55.282 pg/ml ) and C-reactive protein (-21.656 mg/l ) levels, while increasing gavage intake (326.680 ml/day ) and improving some clinical outcomes (APACHE II, SOFA and NUTRIC scores) compared to control group. Melatonin 65-74 interleukin 6 Homo sapiens 97-110 35212485-7 2022 saSE with SScDFs generated a thicker and stiffer dermis, and secreted more IL-6 and TGF-beta compared to saSE with NDFs, regardless of the inclusion of monocytes. sase 0-4 interleukin 6 Homo sapiens 75-79 35242878-10 2022 Proinflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) and anti-inflammatory cytokine (IL-10) were all positively associated with several BA species, especially the conjugated secondary BAs. Bile Acids and Salts 141-143 interleukin 6 Homo sapiens 37-41 35282448-4 2022 Subsequently, MSCs were stimulated with insulin and glucose thrice daily, resembling food uptake and both glucose uptake/GLUT-4 translocation and the expression of LIPE, ATGL, IL-6 and TNF-alpha genes were analyzed at predefined timepoints over three days. Glucose 52-59 interleukin 6 Homo sapiens 176-180 35222804-5 2022 Additionally, Cr(VI)-induced senescent L02 hepatocytes showed upregulated inflammation-related factors, such as IL-6 and fibroblast growth factor 23 (FGF23), which also exhibited reactive oxygen species (ROS) accumulation derived from mitochondria accompanied with increased concentration of intracellular calcium ions (Ca2+) and activity of nuclear factor kappa B (NF-kappaB). Reactive Oxygen Species 179-202 interleukin 6 Homo sapiens 112-116 35182412-3 2022 TNFalpha caused an increase in interleukin (IL)-6 and IL-8 release which was inhibited by curcumin in a dose-dependent manner (IC50 = 3.4 muM for IL-6). Curcumin 90-98 interleukin 6 Homo sapiens 31-49 35182412-3 2022 TNFalpha caused an increase in interleukin (IL)-6 and IL-8 release which was inhibited by curcumin in a dose-dependent manner (IC50 = 3.4 muM for IL-6). Curcumin 90-98 interleukin 6 Homo sapiens 146-150 35222804-5 2022 Additionally, Cr(VI)-induced senescent L02 hepatocytes showed upregulated inflammation-related factors, such as IL-6 and fibroblast growth factor 23 (FGF23), which also exhibited reactive oxygen species (ROS) accumulation derived from mitochondria accompanied with increased concentration of intracellular calcium ions (Ca2+) and activity of nuclear factor kappa B (NF-kappaB). Calcium 306-313 interleukin 6 Homo sapiens 112-116 35222804-6 2022 Of note is that ROS inhibition by N-acetyl-Lcysteine pretreatment not only alleviated Cr(VI)-induced premature senescence but also reduced the elevated intracellular Ca2+, activated NF-kappaB, and secretion of IL-6/FGF23. Reactive Oxygen Species 16-19 interleukin 6 Homo sapiens 210-214 35172141-0 2022 Interleukin-6 triggers toxic neuronal iron sequestration in response to pathological alpha-synuclein. Iron 38-42 interleukin 6 Homo sapiens 0-13 35172141-4 2022 IL-6, via its trans-signaling pathway, induces changes in the neuronal iron transcriptome that promote ferrous iron uptake and decrease cellular iron export via a pathway we term the cellular iron sequestration response, or CISR. Iron 71-75 interleukin 6 Homo sapiens 0-4 35172141-4 2022 IL-6, via its trans-signaling pathway, induces changes in the neuronal iron transcriptome that promote ferrous iron uptake and decrease cellular iron export via a pathway we term the cellular iron sequestration response, or CISR. Iron 145-149 interleukin 6 Homo sapiens 0-4 35172141-4 2022 IL-6, via its trans-signaling pathway, induces changes in the neuronal iron transcriptome that promote ferrous iron uptake and decrease cellular iron export via a pathway we term the cellular iron sequestration response, or CISR. Iron 192-196 interleukin 6 Homo sapiens 0-4 35226999-7 2022 Higher cortisol levels during pregnancy were associated with elevated IL-6 concentrations. Hydrocortisone 7-15 interleukin 6 Homo sapiens 70-74 35152373-7 2022 Patients with a higher blood Cu/Zn ratio had lower levels of hemoglobin, blood zinc, serum prealbumin, albumin, and creatinine as well as low SGA and GNRI scores, but higher modified Charlson comorbidity index score, serum C-reactive protein level, interleukin-6 level, blood copper level, and NRS2002 score (all p < 0.05). Copper 29-31 interleukin 6 Homo sapiens 249-262 35147475-0 2022 Pretreatment serum level of interleukin-6 predicts carfilzomib-induced hypertension in relapsed/refractory multiple myeloma. carfilzomib 51-62 interleukin 6 Homo sapiens 28-41 35205125-7 2022 Moreover, GSEA results showed that immune-related pathways, such as epithelial-mesenchymal transition and IL6/JAK/STAT3 signaling were enriched in the high ARPS risk groups, while the low ARPS risk group mainly regulated metabolism-related processes, such as adipogenesis and bile acid metabolism. gsea 10-14 interleukin 6 Homo sapiens 106-109 35205125-7 2022 Moreover, GSEA results showed that immune-related pathways, such as epithelial-mesenchymal transition and IL6/JAK/STAT3 signaling were enriched in the high ARPS risk groups, while the low ARPS risk group mainly regulated metabolism-related processes, such as adipogenesis and bile acid metabolism. Bile Acids and Salts 276-285 interleukin 6 Homo sapiens 106-109 35432966-3 2022 The protective effect of FDOP on the damage of human skin fibroblasts (HSF) caused by ultraviolet (UV) radiation was investigated by evaluating its antioxidative and antiaging indices. fdop 25-29 interleukin 6 Homo sapiens 71-74 35152875-4 2022 METHODS: In this cross-sectional study, serum levels of interleukins (IL)-6 and IL-1beta and MDA (malondialdehyde) were quantified by ELISA and colorimetry, respectively , patients with ACS (n = 48; 31.3% with UA, 33.3% with NSTEMI, and 35.4% with STEMI) and healthy controls (n = 43). Malondialdehyde 98-113 interleukin 6 Homo sapiens 56-75 35204788-8 2022 However, ibuprofen (25 microg/mL for 3 days) significantly decreased mean secretion of: CCL2 (by 44%), HGF (by 31%), IL-6 (by 22%), VEGF (by 20%) and IL-4 (by 8%) compared to secretion of control MSCs (p < 0.05). Ibuprofen 9-18 interleukin 6 Homo sapiens 117-121 35147475-5 2022 The pretreatment serum level of interleukin-6 was identified as a significant risk factor for CFZ-related hypertension. carfilzomib 94-97 interleukin 6 Homo sapiens 32-45 35147475-6 2022 This study revealed hypertension as the most frequent CFZ-related CVAE and suggested that baseline serum interleukin-6 is a useful predictor for CFZ-induced hypertension. carfilzomib 54-57 interleukin 6 Homo sapiens 105-118 35061945-5 2022 Our previous work showed that a novel anthranilate analogue (SI-W052) inhibited lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 on microglia. si-w052 61-68 interleukin 6 Homo sapiens 151-169 35199049-6 2022 The current literature bears strong evidence for the benefits of yoga on the levels of circulating cortisol and classical inflammatory markers, such as C-reactive protein (CRP) and cytokines such as interleukin-1 beta (IL-1beta), interleukin 6 (IL-6), tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (INF-gamma). Hydrocortisone 99-107 interleukin 6 Homo sapiens 245-249 35185902-9 2022 On the other hand, inhibition of NOX-associated ROS production decreased virus replication and cell death, as well as the secretion of inflammatory cytokines, including IL-6, IL-8, and CCL5. Reactive Oxygen Species 48-51 interleukin 6 Homo sapiens 169-173 35062054-6 2022 The cumulative evidence synthesized in the current review suggests that, traditional therapies which include thiazolidinediones, statins and some calcium channel blockers can be useful in the primary prevention of atherosclerosis by inhibiting the formation of monocyte-derived microparticles, and pro-inflammatory cytokines such as IL-6, TNF-alpha, MCP-1, and NF-kappaB in patients with T2D. Calcium 146-153 interleukin 6 Homo sapiens 333-337 32345077-4 2022 In addition, the mean serum level of IL6, hsCRP and TNFalpha significantly decreased in the study group in comparison to the placebo group and as compared to their baseline results.Conclusion: Vitamin D deficiency is more common in CSU patients as compared to healthy people and hence, alfacalcidol might have a beneficial role as add on therapy in CSU management with no reported side effects. Vitamin D 193-202 interleukin 6 Homo sapiens 37-40 35098408-12 2022 Moreover, miR-520-3p inhibitor downregulated the levels of inflammatory factors of TNF-alpha, IL-6, and IL-1beta, as well as suppressed NO release. mir-520-3p 10-20 interleukin 6 Homo sapiens 94-98 35171704-10 2022 In IFN-gamma stimulated condition, pretreatment with HC-5 muM resulted in a significantly increased IL-6 and significantly decreased COX-2 expression compared to the HC untreated control group. Hydrocortisone 53-55 interleukin 6 Homo sapiens 100-104 35422571-8 2022 After the Analyze we suggest the use of response nutraceutical therapy associated with dexamethasone can reduce the expression of Interlukina-6(IL-6) and myalgia due to COVID-19. Dexamethasone 87-100 interleukin 6 Homo sapiens 144-148 35422571-9 2022 Conclusion: According the scientific literature nutraceutical therapy associated with dexamethasone can reduce the expression of Interlukina-6(IL-6) and myalgia due to COVID-19. Dexamethasone 86-99 interleukin 6 Homo sapiens 143-147 35040210-6 2022 Besides, a considerable difference was observed between the nano-curcumin and control groups in the expression of IFN-gamma (p = 0.001), IL-1beta (p = 0.0002), and IL-6 (p = 0.008). Curcumin 65-73 interleukin 6 Homo sapiens 164-168 35228136-9 2022 RESULTS: At baseline, IL-6 was associated with the Apnea-Hypopnea Index (beta = 0.013, p = 0.03), and the Oxygen Desaturation Index (beta = 0.028, p = 0.002). Oxygen 106-112 interleukin 6 Homo sapiens 22-26 35061708-6 2022 Furthermore, RNA-seq results manifested that the melatonin treatment led to a significant increase in the expression levels of HPGD, IL2Rbeta, NGFR, however, IGFBP3 and IL6 (P <0.05) had decreased expression levels. Melatonin 49-58 interleukin 6 Homo sapiens 169-172 35173714-6 2022 However, ATRA attenuated TGEV-induced inflammatory response by inhibiting the release of pro-inflammatory cytokines, including IL-1beta, IL-6, IL-8 and TNF-alpha. Tretinoin 9-13 interleukin 6 Homo sapiens 137-141 35213991-6 2022 The combination of both ATOR and miRNA drastically reduced the levels of proinflammatory cytokines such as IL-6 and TNF-alpha and of reactive oxygen species (ROS) in LPS-activated macrophages and vessel endothelial cells. Atorvastatin 24-28 interleukin 6 Homo sapiens 107-111 35126343-7 2021 Cholesterol-conjugated RNA (RNA-chol) formed nanoparticles that were superior to RNA-liposomes complexes in regard to induction of type I interferon from human and murine plasmacytoid dendritic cells as well as proinflammatory cytokine production (e.g. TNF-alpha, IL12p70 or IL-6) in human monocytes. Cholesterol 0-11 interleukin 6 Homo sapiens 275-279 35387716-8 2022 In patients with sepsis, plasma cholesterol levels were correlated with the degree of inflammation and severity of the disease to varying degrees, but the HDL-C had the strongest correlation with interleukin-6 (IL-6; r = -0.551, P = 0.000), procalcitonin (PCT, r = -0.598, P = 0.000), sequential organ failure assessment (SOFA; r = -0.285, P = 0.000). Cholesterol 32-43 interleukin 6 Homo sapiens 196-209 35387716-8 2022 In patients with sepsis, plasma cholesterol levels were correlated with the degree of inflammation and severity of the disease to varying degrees, but the HDL-C had the strongest correlation with interleukin-6 (IL-6; r = -0.551, P = 0.000), procalcitonin (PCT, r = -0.598, P = 0.000), sequential organ failure assessment (SOFA; r = -0.285, P = 0.000). Cholesterol 32-43 interleukin 6 Homo sapiens 211-215 35155394-4 2022 We engineered a model lactic acid bacterium, Lactococcus lactis, to co-display on its surface a protein ligand for tumor antigens (EpCAM-binding affitin; HER2-binding affibody) and a ligand for pro-inflammatory cytokines (IL-8-binding evasin; IL-6-binding affibody). Lactic Acid 22-33 interleukin 6 Homo sapiens 243-247 35060899-9 2022 Cells with TT variant exposed to an MDA5 agonist showed an increase in IL6 expression after dexamethasone treatment. Dexamethasone 92-105 interleukin 6 Homo sapiens 71-74 35060899-11 2022 Patients with a TT variant treated with dexamethasone showed an increased hospital mortality (HR: 2.19, 95% CI: 1.01-4.87) and serum IL-6. Dexamethasone 40-53 interleukin 6 Homo sapiens 133-137 35163066-4 2022 In the present study, we demonstrated, by using both primary epidermal keratinocytes (NHEK) and a 3D epidermis model, that paclitaxel impairs different cellular processes: paclitaxel increased the release of IL-1alpha, IL-6, and IL-8 inflammatory cytokines, produced reactive oxygen species (ROS) release and apoptosis, and reduced the endothelial tube formation in the dermal microvascular endothelial cells (HDMEC). Paclitaxel 123-133 interleukin 6 Homo sapiens 219-223 35163066-4 2022 In the present study, we demonstrated, by using both primary epidermal keratinocytes (NHEK) and a 3D epidermis model, that paclitaxel impairs different cellular processes: paclitaxel increased the release of IL-1alpha, IL-6, and IL-8 inflammatory cytokines, produced reactive oxygen species (ROS) release and apoptosis, and reduced the endothelial tube formation in the dermal microvascular endothelial cells (HDMEC). Paclitaxel 172-182 interleukin 6 Homo sapiens 219-223 35111793-7 2021 In contrast, 25(OH)D levels were only borderline statistically significant correlated with IL-6 (r = -0.14; p <0.050). 25(oh)d 13-20 interleukin 6 Homo sapiens 91-95 35096275-9 2022 Conclusions: Elevated Lp(a) levels upregulate alpha7-nAChR/IL-6/p38 MAPK signaling in macrophages of CAS patients and HCASMC, suggesting that Lp(a)-triggered inflammation mediates CAS through alpha7-nAChR/p38 MAPK/IL-6/RhoA-GTP signaling induction, macrophage M1 polarization, and HCASMC activation. Guanosine Triphosphate 224-227 interleukin 6 Homo sapiens 59-63 35040511-8 2022 Progesterone showed a unique ability to attenuate the enhanced TNFalpha and IL-6 production following oxLDL-induced trained immunity. Progesterone 0-12 interleukin 6 Homo sapiens 76-80 35055116-3 2022 The function of these antibodies is similar to that of natural ligands, and it involves not only vasoconstriction, but also the secretion of proinflammatory cytokines (such as interleukin-6 (IL6), IL8 and TNF-alpha), collagen production by fibroblasts, and reactive oxygen species (ROS) release by fibroblasts and neutrophils. Reactive Oxygen Species 257-280 interleukin 6 Homo sapiens 176-189 35055116-3 2022 The function of these antibodies is similar to that of natural ligands, and it involves not only vasoconstriction, but also the secretion of proinflammatory cytokines (such as interleukin-6 (IL6), IL8 and TNF-alpha), collagen production by fibroblasts, and reactive oxygen species (ROS) release by fibroblasts and neutrophils. Reactive Oxygen Species 282-285 interleukin 6 Homo sapiens 176-189 35050236-0 2022 Vitamin D Inhibits IL-6 Pro-Atherothrombotic Effects in Human Endothelial Cells: A Potential Mechanism for Protection against COVID-19 Infection? Vitamin D 0-9 interleukin 6 Homo sapiens 19-23 34843183-9 2022 Urine albumin/creatinine-ratios correlated positively with plasma IL-6 at baseline. Creatinine 14-24 interleukin 6 Homo sapiens 66-70 35022042-4 2022 METHODS: Intra- and extracellular iron was measured in cell-line-derived and in freshly isolated sputum macrophages under various experimental conditions including treatment with exogenous IL-6 and hepcidin. Iron 34-38 interleukin 6 Homo sapiens 189-193 35022042-8 2022 IL-6 and hepcidin play roles in pulmonary iron sequestration, though IL-6 appears to exert its effect via a hepcidin-independent mechanism. Iron 42-46 interleukin 6 Homo sapiens 0-4 35022042-12 2022 Specifically, IL-6-dependent iron sequestration by sputum macrophages may result in immune cell dysfunction and ultimately lead to increased frequency of infective exacerbation. Iron 29-33 interleukin 6 Homo sapiens 14-18 35126884-0 2022 Montelukast is a dual-purpose inhibitor of SARS-CoV-2 infection and virus-induced IL-6 expression identified by structure-based drug repurposing. montelukast 0-11 interleukin 6 Homo sapiens 82-86 35126884-6 2022 With distinct binding sites for RBD and the leukotriene receptor, montelukast also prevented SARS-CoV-2-induced IL-6 release from immune cells. montelukast 66-77 interleukin 6 Homo sapiens 112-116 35071884-7 2022 To establish the anticancer mechanism of LAS-based bioconjugates, the levels of interleukin 6 (IL-6) and reactive oxygen species (ROS) were measured; the tested compounds significantly reduced the release of IL-6, while the level of ROS was significantly higher in all the cell lines studied. Reactive Oxygen Species 130-133 interleukin 6 Homo sapiens 208-212 34409772-9 2022 Baseline Charlson Comorbidity Index score (OR 0.36; p = 0.03 (0.14, 0.89)) was independently associated with total testosterone levels at 7-month follow-up, after adjusting for age, BMI, and IL-6 at hospital admittance. Testosterone 115-127 interleukin 6 Homo sapiens 191-195 35125691-10 2022 In addition, presence of low folate, and hyperhomocysteinemia was observed in the present study, may be the contributing factors for the hypomethylation of IL-6 and TNF-alpha and oxidative stress. Folic Acid 29-35 interleukin 6 Homo sapiens 156-160 35355720-15 2022 Current evidence supports the antioxidant and anti-inflammatory properties of resveratrol, but its relationship with the levels of some inflammatory cytokines such as IL-6 and TNF-alpha in animals with diabetic nephropathy needs further elucidation. Resveratrol 78-89 interleukin 6 Homo sapiens 167-171 35228490-14 2022 It was concluded that a single large dose of vitamin D was able to reduce the C-reactive protein in non-ST-elevation acute coronary syndrome patients while non-significant reductions in interleukin-6 and tumor necrosis factor-alpha were observed. Vitamin D 45-54 interleukin 6 Homo sapiens 186-199 35379386-10 2022 Meta-analysis showed that patients that were vitamin D sufficient (levels >30ng/mL) had statistically significant lower levels of IL-6, CRP, ferritin, LDH, fibrinogen, and D-dimer compared to vitamin D deficient group. Vitamin D 45-54 interleukin 6 Homo sapiens 130-134 35396024-5 2022 Elevated proinflammatory cytokines (specifically, interleukin-6) in CSF imply the role of neuroinflammation resulting in activation of the tryptophan-kynurenine pathway. Tryptophan 139-149 interleukin 6 Homo sapiens 50-63 35133941-11 2022 The unique features of C14mab may offer a novel alternative for IL-6 blockade and illuminate a better therapeutic intervention targeting IL-6. illuminate 82-92 interleukin 6 Homo sapiens 137-141 2675620-3 1989 IL-6 immunoreactivity was detected by the avidin-biotin-complex (ABC) procedure using a polyclonal rabbit antiserum raised against an E coli-derived human IL-6 (rIL-6). avidin-biotin 42-55 interleukin 6 Homo sapiens 0-4 2511437-5 1989 The 115-base pair (bp) region from -225 to -111 in the IL-6 5"-flanking region, which shares nucleotide sequence similarity with the c-fos serum response (SRE) and adjacent AP-1-like (the CGTCA motif) elements, confers responsiveness to several reagents, including serum, forskolin, and phorbol ester, upon the heterologous herpesvirus thymidine kinase (TK) promoter. Phorbol Esters 287-300 interleukin 6 Homo sapiens 55-59 2511437-9 1989 Mutations in the AP-1-like site within AR1 (CGTCA----GTTCA) decreased inducibility of the chimeric IL-6/TK/chloramphenicol acetyltransferase gene by phorbol ester and by forskolin but not by serum, IL-1 alpha, or tumor necrosis factor. Phorbol Esters 149-162 interleukin 6 Homo sapiens 99-103 2789018-5 1989 In the presence of tunicamycin, IL-6 is secreted exclusively in the O-glycosylated form, whereas in the presence of cycloheximide the pathway leading to both N- and O-glycosylation is dominant. Tunicamycin 19-30 interleukin 6 Homo sapiens 32-36 2523818-8 1989 Incubation of monocytes with tunicamycin and 1-deoxymynnojirimycin and treatment of IL-6 with endoglucosaminidase H suggested that the 27.5 kDa form of IL-6 carries at least one N-linked complex-type oligosaccharide chain. Tunicamycin 29-40 interleukin 6 Homo sapiens 152-156 2523818-8 1989 Incubation of monocytes with tunicamycin and 1-deoxymynnojirimycin and treatment of IL-6 with endoglucosaminidase H suggested that the 27.5 kDa form of IL-6 carries at least one N-linked complex-type oligosaccharide chain. 1-deoxymynnojirimycin 45-66 interleukin 6 Homo sapiens 152-156 2460462-0 1988 Phorbol ester modulates interleukin 6- and interleukin 1-regulated expression of acute phase plasma proteins in hepatoma cells. Phorbol Esters 0-13 interleukin 6 Homo sapiens 24-37 2460462-2 1988 Phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), partially mimics the stimulatory effect of IL-6 but reduces that effect of IL-1. Phorbol Esters 0-13 interleukin 6 Homo sapiens 102-106 2503436-7 1989 The anti-CD3-induced thymidine uptake by T cells in the presence of IL-1 and IL-6 was significantly inhibited by anti-Tac antibody, suggesting that the proliferation of T cells in this system is mostly mediated by a IL-2-dependent pathway. Thymidine 21-30 interleukin 6 Homo sapiens 77-81 4084549-5 1985 Of special interest, tyrosine A, phenylalanine A, tryptophan B1, and tryptophan B2 were found to be located close to a cluster of aliphatic residues, indicating that the hydrophobic site of the HSF is conformationally rigid and its tertiary structure very compact. phenylalanine a 33-48 interleukin 6 Homo sapiens 194-197 2784752-2 1989 The uptake of [3H]thymidine into DNA was measured on stimulation with a range of interleukins (IL-2, IL-4, and IL-6) and solid-phase anti-IgM. Thymidine 18-27 interleukin 6 Homo sapiens 111-115 2787245-7 1989 Polymers of oligonucleotides containing either the A or the C regions confer IL-6 responsiveness to a truncated SV40 promoter. Polymers 0-8 interleukin 6 Homo sapiens 77-81 3545852-0 1987 Interleukin 1 and poly(rI).poly(rC) induce production of a hybridoma growth factor by human fibroblasts. Poly C 27-35 interleukin 6 Homo sapiens 59-82 6693432-4 1984 The combination of HSF and PS decreased the Km of the normal enzyme for 4-methylumbelliferyl-beta-D-glucopyranoside from 8.0 to 1.6 mM. 4-methylumbelliferyl glucoside 72-115 interleukin 6 Homo sapiens 19-22 3494192-5 1987 Exposure of cells to TNF enhanced IFN-beta 2 (but not IFN-beta 1) mRNA expression in response to poly(I).poly(C), an IFN inducer which is also known to stimulate FS-4 cell growth. Poly C 105-112 interleukin 6 Homo sapiens 34-44 3006091-2 1986 The specific binding and internalization of human 125I-labeled LDL are dose-dependently increased in HSF by CA of the verapamil series (verapamil, anipamil, gallopamil, ronipamil, and diltiazem), but neither by CA of the dihydropyridine series (nifedipine, nitrendipine) nor by flunarizine. Verapamil 118-127 interleukin 6 Homo sapiens 101-104 2452086-12 1988 The inhibition of N-glycosylation by tunicamycin abolished the effect of interleukin-6 on the secretion of alpha 2-macroglobulin, indicating a possible role of interleukin-6 on N-glycosylation. Tunicamycin 37-48 interleukin 6 Homo sapiens 73-86 6440265-9 1984 The NADPH-cytochrome c (P450) reductase of G6PD-deficient HL and HSF homogenates becomes lower than that of controls when endogenous G6PD and exogenous glucose 6-phosphate (G6P) and NADP+ are used as a hydrogen donor system in place of NADPH. Glucose-6-Phosphate 152-171 interleukin 6 Homo sapiens 65-68 6440265-9 1984 The NADPH-cytochrome c (P450) reductase of G6PD-deficient HL and HSF homogenates becomes lower than that of controls when endogenous G6PD and exogenous glucose 6-phosphate (G6P) and NADP+ are used as a hydrogen donor system in place of NADPH. Glucose-6-Phosphate 43-46 interleukin 6 Homo sapiens 65-68 3006091-2 1986 The specific binding and internalization of human 125I-labeled LDL are dose-dependently increased in HSF by CA of the verapamil series (verapamil, anipamil, gallopamil, ronipamil, and diltiazem), but neither by CA of the dihydropyridine series (nifedipine, nitrendipine) nor by flunarizine. Verapamil 136-145 interleukin 6 Homo sapiens 101-104 6601516-2 1983 HSF was found to have a wide pH stability (pH 3-10), sensitivity to temperatures greater than 80 degrees C, and to have the properties of a glycoprotein by virtue of its sensitivity to chymotrypsin, trypsin, sodium periodate, and neuraminidase. metaperiodate 208-224 interleukin 6 Homo sapiens 0-3 3006091-2 1986 The specific binding and internalization of human 125I-labeled LDL are dose-dependently increased in HSF by CA of the verapamil series (verapamil, anipamil, gallopamil, ronipamil, and diltiazem), but neither by CA of the dihydropyridine series (nifedipine, nitrendipine) nor by flunarizine. Nitrendipine 257-269 interleukin 6 Homo sapiens 101-104 33857595-13 2021 Furthermore, isoorientin, orientin, isovitexin, and vitexin produced significant concentration-dependent inhibition with IC50 values (muM) of COX-2: 7.13, 9.51, 12.81, 16.61; IL-1beta 4.80, 6.20, 10.85, 14.51; IL-6: 4.01, 5.90, 11.51 and 14.88 as compared to dexamethasone: 5.29, 2.93, 3.72, respectively (p<0.05). orientin 16-24 interleukin 6 Homo sapiens 210-214 3966907-4 1985 In HSF and SMC, a delay in 125I-LDL degradation and hydrolysis of 3H-CL was seen in cells treated for 3 to 24 hours with verapamil. Verapamil 121-130 interleukin 6 Homo sapiens 3-6 34053234-8 2021 Moreover, the release of interleukin-6 (IL-6) was mitigated by ligustilide in a YAP-dependent manner in HCC cells, concomitant with inhibition of IL-6R/STAT3 signaling activation. ligustilide 63-74 interleukin 6 Homo sapiens 40-44 3966907-5 1985 Pretreatment of HSF with 50 microM verapamil for 24 hours and incubation with 2 to 50 micrograms 125I-LDL protein/ml for 1 hour resulted in a 50% to 200% increase in heparin releasable and in a 40% to 130% increase in cellular 125I-LDL. Verapamil 35-44 interleukin 6 Homo sapiens 16-19 6352808-1 1983 The incubation of CESS cells with BCDF induced phospholipid methylation, i.e., 3H-methyl incorporation into phosphatidylcholine and phosphatidyl-N-monomethyl-ethanolamine, within 15 to 30 min. Phosphatidylcholines 108-127 interleukin 6 Homo sapiens 34-38 6352808-1 1983 The incubation of CESS cells with BCDF induced phospholipid methylation, i.e., 3H-methyl incorporation into phosphatidylcholine and phosphatidyl-N-monomethyl-ethanolamine, within 15 to 30 min. phosphatidyl-n-monomethyl-ethanolamine 132-170 interleukin 6 Homo sapiens 34-38 6352808-3 1983 The inhibitors of methyltransferase, SIBA, adenosine, or HEH showed a dose-dependent inhibitory effect not only on phospholipid methylation but also on serine esterase activation and on BCDF-induced IgG production; DFP inhibited IgG production but not phospholipid methylation. 5'-deoxy-5'-S-isobutylthioadenosine 37-41 interleukin 6 Homo sapiens 186-190 33930649-11 2021 The green tea extract and EGCG also had a dose-dependent inhibitory effect on irinotecan-induced secretion of interleukin-6 and interleukin-8 by oral epithelial cells. epigallocatechin gallate 26-30 interleukin 6 Homo sapiens 110-123 34052845-8 2021 In vivo, 3-MA and LY294002 repressed Ti particle-stimulated osteolysis and osteoclastogenesis and reduced expression of the pro-inflammatory factors TNF-alpha, IL-1beta, and IL-6. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 18-26 interleukin 6 Homo sapiens 174-178 33894403-7 2021 Furthermore, NP-RLX ameliorated the chronic AAD-induced AI, pro-inflammatory cytokines (IL-1beta, IL-6, TNF-alpha), chemokines (CCL2, CCL11) and the pro-fibrotic TGF-beta1/IL-1beta axis on AWR and resulting AHR, as well as human myofibroblast-induced collagen gel contraction, to a similar extent as unconjugated RLX. np-rlx 13-19 interleukin 6 Homo sapiens 98-102 34053234-0 2021 Ligustilide counteracts carcinogenesis and hepatocellular carcinoma cell-evoked macrophage M2 polarization by regulating yes-associated protein-mediated interleukin-6 secretion. ligustilide 0-11 interleukin 6 Homo sapiens 153-166 34053234-8 2021 Moreover, the release of interleukin-6 (IL-6) was mitigated by ligustilide in a YAP-dependent manner in HCC cells, concomitant with inhibition of IL-6R/STAT3 signaling activation. ligustilide 63-74 interleukin 6 Homo sapiens 25-38 33846227-7 2021 However, at the output of the nucleus, the combination of M-triDAP and LPS synergistically induces expression of a subset of M-triDAP- and LPS-inducible genes, particularly those encoding proinflammatory cytokines (TNF, IL1B, IL6, IL12B, and IL23A). m-tridap 58-66 interleukin 6 Homo sapiens 226-229 34053234-9 2021 Of interest, interdicting the IL-6 aggravated ligustilide-mediated suppression in HCC-induced macrophage recruitment and M2 polarization; whereas exogenous IL-6 treatment reversed the above effects. ligustilide 46-57 interleukin 6 Homo sapiens 30-34 33675827-7 2021 The loading of LVOX into CH/ZA induced its anti-inflammatory effect against the cytokine production (IL-6 and IL-8) within the human bronchial epithelia cells (NL20). Levofloxacin 15-19 interleukin 6 Homo sapiens 101-105 34053234-11 2021 Consequently, these findings support a notion that ligustilide not only restrains HCC cell malignancy but also antagonizes HCC cell-evoked macrophage recruitment and M2 polarization by inhibiting YAP/IL-6 release-induced activation of the IL-6 receptor/signal transducer and activator of transcription 3 (IL-6R/STAT3) signaling. ligustilide 51-62 interleukin 6 Homo sapiens 200-204 33926561-15 2021 Furthermore, Cur-EVs increased gene expression of BCL2, ACAN, SOX9, and COL2A1 and decreased gene expression of IL1B, IL6, MMP13, and COL10A1 in IL-1beta-stimulated OA-CH. cur-evs 13-20 interleukin 6 Homo sapiens 118-121 34031685-8 2021 The results of the immune factor assays indicated that puerarin propanoate, puerarin hexanoate and puerarin myristate could significantly promote the secretion of IL-6, TNF-alpha and IL-10. puerarin myristate 99-117 interleukin 6 Homo sapiens 163-167 33485977-12 2021 ELISA and Western blot demonstrated that bufothionine significantly reduced serum IL-6 concentration, suppressed p-Stat3tyr705, p-Stat3ser727 and Jak2 expressions in tumor tissues and upregulated Atg5, Atg7 and LC3II expressions in SMMC7721 cell and H22 tumor. bufothionine 41-53 interleukin 6 Homo sapiens 82-86 33962178-6 2021 The impedimetric immunosensor was developed on a BP-PAMI modified laser burned graphene (LBG) to detect interleukin-6 biomarkers using electrochemical impedance spectroscopy (EIS). bp-pami 49-56 interleukin 6 Homo sapiens 104-117 33963719-8 2021 Several key targets including AKT1, IL- 6, JUN, TNF and CASP3 were screened for molecular docking, which had good binding activities with berberrubine, epiberberine, stigmasterol and sitosterol. berberrubine 138-150 interleukin 6 Homo sapiens 36-41 33878273-7 2021 We also show that soft AIE dots loaded with cytosine-phosphate-guanine (CpG) oligodeoxynucleotides can induce strong immunostimulatory effects, producing a high level of various proinflammatory cytokines including tumor necrosis factor (TNF)-R, interleukin (IL)-6, and IL-12. Oligodeoxyribonucleotides 77-98 interleukin 6 Homo sapiens 245-263 33963722-7 2021 On D2, TNF-alpha, L-1beta and IL-6 recovered their baseline levels in medium- and high-dose DEX groups (P > 0.05) but remained elevated in the other two groups. Dexmedetomidine 92-95 interleukin 6 Homo sapiens 30-34 33933750-12 2021 CONCLUSIONS: We introduce a strategy for adjusting vitamin A in the context of clinical illness based on IL-6 concentrations that will need to be validated in larger studies. Vitamin A 51-60 interleukin 6 Homo sapiens 105-109 33919169-1 2021 Here, we report on the role of haptoglobin (Hp), whose expression depends on the synthesis of interleukin 6 (IL-6), related to the pathogenesis of multiple sclerosis (MS), as a possible marker of muscle improvement achieved after treatment with the polyphenol epigallocatechin gallate (EGCG) and an increase in the ketone body beta-hydroxybutyrate (BHB) in the blood. epigallocatechin gallate 286-290 interleukin 6 Homo sapiens 109-113 33860869-10 2021 Further experiments revealed that S1-induced increase in the production of TNFalpha, IL-6, IL-1beta and IL-8 was reduced in the presence of BAY11-7082 and SKF 86002, while CRID3 pre-treatment resulted in the reduction of IL-1beta production. 6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole 155-164 interleukin 6 Homo sapiens 85-89 33582286-3 2021 Transcriptomics and proteomics analysis of the IL6-OE liver revealed a deregulation of glycolysis/gluconeogenesis pathway, especially a striking down regulation of the glycolytic enzyme aldolase b. Metabolomics analysis by mass spectrometry showed accumulation of hexose monophosphates and their derivatives, which can act as precursors for triglyceride synthesis. hexose monophosphates 264-285 interleukin 6 Homo sapiens 47-50 33853291-11 2021 After PMX-DHP, the mean P/F ratio improved (86 [range, 63-106] vs. 145 [86-260], P=0.030) and interleukin-6 and c-reactive protein decreased (79 [35-640] vs. 10 [5-25], P=0.018 and 14 [4-21] vs. 5 [2-6], P=0.019, respectively). pmx-dhp 6-13 interleukin 6 Homo sapiens 94-107 33833542-7 2021 Hypotonic liquid exudation from the nasal surface detaches and drains the inflammatory cytokines and other contaminants towards the film where selected polymers bind and neutralize SARS-CoV-2 spike S1 and RBD protein as well as Covid-19 disease-specific key pro-inflammatory IL-6, TNF-alpha, IL-10, IL-13, and GM-CSF cytokines. Polymers 152-160 interleukin 6 Homo sapiens 275-279 33641076-4 2021 In vivo, Dex markedly reduced pulmonary edema induced by LPS through promoting AFC, prevented LPS-induced downregulation of alpha-, beta-, and gamma-ENaC expression, attenuated inflammatory cell infiltration in lung tissue, reduced the concentrations of TNF-alpha, IL-1beta, and IL-6, and increased concentrations of IL-10 in bronchoalveolar lavage fluid (BALF). Dexmedetomidine 9-12 interleukin 6 Homo sapiens 279-283 33125572-3 2021 We also demonstrated that oridonin abrogated inflammation through inhibiting the phosphorylation of NF-kappaBp65 as well as its downstream gene (iNOS, COX-2, IL-1beta, and IL-6) level. oridonin 26-34 interleukin 6 Homo sapiens 172-176 33834669-9 2021 Sitagliptin suppressed 5 microg mL-1 of LPS-induced IL-6, IL-8, CCL2, and SOD2 gene expression levels in HGF in a concentration-dependent manner. Sitagliptin Phosphate 0-11 interleukin 6 Homo sapiens 52-56 33834669-10 2021 Furthermore, sitagliptin significantly decreased the elevated secretion of IL-6, IL-8, and CCL2 protein induced by LPS. Sitagliptin Phosphate 13-24 interleukin 6 Homo sapiens 75-79 33834669-12 2021 Results of qRT-PCR analysis indicated that 0.5 micromol L-1 of sitagliptin and 5 micromol L-1 of BAY11-7082 significantly inhibited LPS-induced IL-6, IL-8, CCL2, and SOD2 gene expressions. Sitagliptin Phosphate 63-74 interleukin 6 Homo sapiens 144-148 33507306-5 2021 We found that tunicamycin-induced ER stress inhibited NF-kappaB activation and pro-inflammatory cytokine (IL-6 and COX2) production in TNF-alpha- or IL-1beta-treated normal endometrial stromal cells (NECSs). Tunicamycin 14-25 interleukin 6 Homo sapiens 106-110 33507306-9 2021 In contrast, upregulation of ER stress by tunicamycin significantly reduced IL-6 and COX2 production by inhibiting NF-kappaB activity in ECSCs. Tunicamycin 42-53 interleukin 6 Homo sapiens 76-80 33644540-11 2021 Results: The upregulated iNOS, excessive production of NO, IL-6, and MCP-1, and activated COX-2/PGE2 signaling pathways in the astrocytes induced by isoflurane were significantly reversed by the introduction of roflumilast, in a dose-dependent manner. Isoflurane 149-159 interleukin 6 Homo sapiens 59-63 33393185-13 2021 For the in vitro experiments, we observed that IL-6 significantly increased p16, STAT3, GP130, and p62, induced higher SA-beta-gal staining, while downregulated LC3II and autophagosome. 2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid 119-130 interleukin 6 Homo sapiens 47-51 32559758-7 2021 RESULTS: IL-6 and IL-8 were highly expressed in pediatric Q-CPs, and the transcription level of IL-6 was the highest in the severe group. q-cps 58-63 interleukin 6 Homo sapiens 9-13 33758527-6 2021 UHPLC profiled Coronil also modulated S-protein mediated production of pro-inflammatory cytokines in A549 cells, like interleukin-6 (IL-6), interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha), as evaluated through RT-qPCR and ELISA. coronil 15-22 interleukin 6 Homo sapiens 118-131 33758527-6 2021 UHPLC profiled Coronil also modulated S-protein mediated production of pro-inflammatory cytokines in A549 cells, like interleukin-6 (IL-6), interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha), as evaluated through RT-qPCR and ELISA. coronil 15-22 interleukin 6 Homo sapiens 133-137 33498195-8 2021 Indeed, it was observed that both FM and DFM decreased the IL-6, IL-8, and nitric oxide (NO) release similarly to the reference anti-inflammatory drug dexamethasone. N-ACETYL-L-PHENYLALANYL-4-[DIFLUORO(PHOSPHONO)METHYL]-L-PHENYLALANINAMIDE 41-44 interleukin 6 Homo sapiens 59-63 33446880-7 2021 Higher levels of TG n-3 polyunsaturated fatty acids (PUFAs) were associated with lower MIS (r = - 0.168) and interleukin-6 concentrations (r = - 0.115). Fatty Acids, Omega-3 20-51 interleukin 6 Homo sapiens 110-123 33446880-7 2021 Higher levels of TG n-3 polyunsaturated fatty acids (PUFAs) were associated with lower MIS (r = - 0.168) and interleukin-6 concentrations (r = - 0.115). Fatty Acids, Unsaturated 53-58 interleukin 6 Homo sapiens 110-123 33758527-8 2021 Treatment with Coronil significantly reduced the increased levels of IL-6, IL-1beta, and TNF-alpha in A549 cells incubated with different S-protein variants in a dose-dependent manner. coronil 15-22 interleukin 6 Homo sapiens 69-73 33556841-9 2021 Melokhanine K and meloyine II showed potent inhibitory activity on the production of nitric oxide, interleukin-6, and tumor necrosis factor-alpha in LPS-induced RAW 264.7 macrophages, whereas epi-scandomelonine and epi-scandomeline exhibited certain cytotoxic activity against MOLT-4 cells with IC50 values 5.2 and 1.5 muM, respectively. meloyine ii 18-29 interleukin 6 Homo sapiens 99-112 33371814-6 2021 TNF-[Formula: see text] stimulated expressions of five mediators (IL6, IL10, IFN[Formula: see text], PTGS2, and CCL2), and AQ and 4-AAQB inhibited IL6 elevation ([Formula: see text]! antroquinonol 123-125 interleukin 6 Homo sapiens 147-150 33371814-6 2021 TNF-[Formula: see text] stimulated expressions of five mediators (IL6, IL10, IFN[Formula: see text], PTGS2, and CCL2), and AQ and 4-AAQB inhibited IL6 elevation ([Formula: see text]! 4-acetylantroquinonol B 130-136 interleukin 6 Homo sapiens 147-150 33870224-3 2021 Here, we present an optimized protocol for the isolation and identification of phosphopeptides from IL-6-stimulated primary human Th-1 cells. Phosphopeptides 79-94 interleukin 6 Homo sapiens 100-104 33142636-5 2021 Three NPs greatly promoted the expression and secretion of interleukin-6 (IL-6), tumor necrosis factor (TNF-alpha), and interleukin-1beta (IL-1beta) in DC cells: C2,3,6 chitosan sulfate-HACC (C2,3,6-HACC; 200 kDa), C3,6 chitosan sulfate-HACC (C3,6-HACC; 200 kDa) and C6 chitosan sulfate-HACC (C6-HACC; 50 kDa). c3,6-hacc 243-252 interleukin 6 Homo sapiens 59-72 33142636-5 2021 Three NPs greatly promoted the expression and secretion of interleukin-6 (IL-6), tumor necrosis factor (TNF-alpha), and interleukin-1beta (IL-1beta) in DC cells: C2,3,6 chitosan sulfate-HACC (C2,3,6-HACC; 200 kDa), C3,6 chitosan sulfate-HACC (C3,6-HACC; 200 kDa) and C6 chitosan sulfate-HACC (C6-HACC; 50 kDa). c6-hacc 293-300 interleukin 6 Homo sapiens 59-72 32734768-1 2021 OBJECTIVE: It was reported that the administration of tramadol in patients with cancer pain who have a higher interleukin 6 (IL-6) serum level led to insufficient pain relief. Tramadol 54-62 interleukin 6 Homo sapiens 110-123 32734768-1 2021 OBJECTIVE: It was reported that the administration of tramadol in patients with cancer pain who have a higher interleukin 6 (IL-6) serum level led to insufficient pain relief. Tramadol 54-62 interleukin 6 Homo sapiens 125-129 33782999-6 2021 Furthermore, the expression of inflammatory factors IL-1beta and IL-6 were increased and NF-kappaB signaling pathway was activated in PAHs mixture-treated cells. pahs mixture 134-146 interleukin 6 Homo sapiens 65-69 33472098-8 2021 EGCG inhibited expression of IL-1beta, IL-6, and TNF-alpha. epigallocatechin gallate 0-4 interleukin 6 Homo sapiens 39-43 33279931-3 2020 We established that the Group 3 MB cell line, Med8A, is chemosensitive (hence Med8A-S), and this is correlated with a basal low phosphorylated state of STAT3, while treatment with IL-6 induced robust increases in pY705-STAT3. py705 213-218 interleukin 6 Homo sapiens 180-184 33122571-15 2021 The incremental change in surgery-induced IL-6 levels was greater in the TIVA group than DEX-TIVA group (P < 0.0001). tiva 73-77 interleukin 6 Homo sapiens 42-46 33080187-8 2020 Meanwhile, overexpression of GSTP1 in TAMs promoted the expression and release of interleukin-6 (IL-6) associated with reduced ADR-induced breast cell death, which was reversed by IL-6 antibody. tams 38-42 interleukin 6 Homo sapiens 82-95 33080187-8 2020 Meanwhile, overexpression of GSTP1 in TAMs promoted the expression and release of interleukin-6 (IL-6) associated with reduced ADR-induced breast cell death, which was reversed by IL-6 antibody. tams 38-42 interleukin 6 Homo sapiens 97-101 33080187-8 2020 Meanwhile, overexpression of GSTP1 in TAMs promoted the expression and release of interleukin-6 (IL-6) associated with reduced ADR-induced breast cell death, which was reversed by IL-6 antibody. tams 38-42 interleukin 6 Homo sapiens 180-184 33596128-4 2021 RESULTS: The results indicated that while palmitate enhances the expression and secretion of TNF-alpha, IL-6, and IL-1beta, and also intracellular ROS level, FA at concentrations of 25, 50, and 75 microg/mL significantly reversed these effects in HepG2 cells. Palmitates 42-51 interleukin 6 Homo sapiens 104-108 33146673-7 2021 RESULTS: The network pharmacology research showed that TCM could decrease IL-6 using several compounds, such as quercetin, ursolic acid, luteolin, and rutin. ursolic acid 123-135 interleukin 6 Homo sapiens 74-78 33146673-11 2021 Quercetin, ursolic acid, luteolin, and rutin could inhibit COVID-19 by downregulating IL-6. ursolic acid 11-23 interleukin 6 Homo sapiens 86-90 33985634-8 2021 The SHEsis online software was used to analyze the linkage disequilibrium(LD) of the IL-6 three-site and the relationship between haplotype and MS. GMDR 0. gmdr 148-152 interleukin 6 Homo sapiens 85-89 33417619-14 2021 The IFN-gamma, IL-6 and IL-10 levels were lower in the Dp group than those in the Cp group (p<0.05). Dipyridamole 55-57 interleukin 6 Homo sapiens 15-19 33262576-10 2020 DEX alleviated the alveolar capillary epithelial structure damage, increased protein expression of ZO-1 and occludin, inhibited elevation of the expression of TNF-alpha and IL-6 in lung tissue and plasma, and increased protein expression of p-PI3K, p-AKT and HIF-1alpha. Dexmedetomidine 0-3 interleukin 6 Homo sapiens 173-177 33125520-10 2021 Several factors, including insulin-like growth factor binding protein 3 (IGFBP3), plasminogen activator inhibitor 1 (PAI1), C-C motif chemokine ligand 2 (CCL2) and IL-6, were upregulated in subcutaneous adipose tissue in relation with SA-beta-gal (p for linear trend across tertiles <0.05) and in pre-adipocytes cultured with inflammatory macrophage conditioned media. 2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid 235-246 interleukin 6 Homo sapiens 164-168 33147850-9 2020 In A549 cells, Coronil attenuated the IL-1beta induced IL-6 and TNF-alpha cytokine secretions, and decreased TNF-alpha induced NF-kappaB/AP-1 transcriptional activity. coronil 15-22 interleukin 6 Homo sapiens 55-59 33285354-6 2021 The highest levels of IL-1beta, IL-6, CCL2 and IL-8 were observed with MSU at 0.5 mg/ml, CPP at 0.01-0.05 mg/ml and BCP at 1 mg/ml after 18-48 h and then decreased. bcp 116-119 interleukin 6 Homo sapiens 32-36 33284965-11 2021 Accordingly, muscle anabolism (mTORC1) and plasma CRP remained unchanged by RE and omega-3, whereas serum IL-6 tended to decrease in omega-3 (pinteraction=0.07). Fatty Acids, Omega-3 133-140 interleukin 6 Homo sapiens 106-110 33200293-1 2022 Here, two series of novel ursolic acid-based 1,2,4-triazolo[1,5-a]pyrimidines derivatives were synthesized and screened for their anti-inflammatory activity by evaluating their inhibition effect of using LPS-induced inflammatory response in RAW 264.7 macrophages in vitro; the effects of different concentrations of the compounds on the secretion of nitric oxide (NO) and inflammatory cytokines including TNF-alpha and IL-6 were evaluated. ursolic acid 26-38 interleukin 6 Homo sapiens 419-423 33423442-9 2020 PMX-DHP subsequently improved oxygenation (PaO2/FiO2 ratio) and decreased the levels of inflammatory markers (interleukin-6, C-reactive protein, and white blood cells). pmx-dhp 0-7 interleukin 6 Homo sapiens 110-123 33357907-4 2021 Higher DDA induced a more pronounced increase in alkaline phosphatase activity, osteopontin (OPN), vascular endothelial growth factor-A (VEGF), interleukin-6 (IL-6), and reduction in monocyte chemoattractant protein-1 (MCP-1), sclerostin (SOST) and dickkopf related protein-1 as compared to lower DDA. dda 7-10 interleukin 6 Homo sapiens 144-157 33117168-8 2020 Further investigation indicated that atractylodin significantly increases PEA and OEA levels and dose-dependently inhibits LPS-induced nitrate, TNF-alpha, IL-1beta, and IL-6 pro-inflammatory cytokine release in BV-2 microglia. atractylodin 37-49 interleukin 6 Homo sapiens 169-173 33188660-10 2020 Conjointly, our data indicate that the overexpression of miR-136-5p has the potential to bind to the 3"-UTR in the mRNAs for IL-6 and CRP and mitigate acute LEDVT, which provides a basis for new therapeutic targets in acute LEDVT treatment. mir-136-5p 57-67 interleukin 6 Homo sapiens 125-129 31965901-8 2020 These results revealed the essential role of autophagy in endothelial cell integrity and revealed that the disruption of endothelial autophagy could lead to significant pathological IL6-dependent EndMT and organ fibrosis.Abbreviations: 3-MA: 3-methyladenine; ATG5: autophagy related 5; EndMT: endothelial-to-mesenchymal transition; HES: hematoxylin and eosin stain; HFD: high-fat diet; HMVECs: human microvascular endothelial cells; IFNG: interferon gamma; IL6: interleukin 6; MTS: Masson"s trichrome staining; NFD: normal-fat diet; siRNA: small interfering RNA; SMAD3: SMAD family member 3; TGFB: transforming growth factor beta; TNF: tumor necrosis factor; VEGFA: vascular endothelial growth factor A. Eosine Yellowish-(YS) 353-358 interleukin 6 Homo sapiens 182-185 33357907-4 2021 Higher DDA induced a more pronounced increase in alkaline phosphatase activity, osteopontin (OPN), vascular endothelial growth factor-A (VEGF), interleukin-6 (IL-6), and reduction in monocyte chemoattractant protein-1 (MCP-1), sclerostin (SOST) and dickkopf related protein-1 as compared to lower DDA. dda 7-10 interleukin 6 Homo sapiens 159-163 33357907-6 2021 The combination of higher DDA and Mw induced an increased secretion of VEGF and IL-6, however reduced the secretion of OPN as compared to chitosan with similar DDA but with lower Mw. dda 26-29 interleukin 6 Homo sapiens 80-84 33053467-4 2021 HUVECs exposed with SiO2 NPs generate excess amount of reactive oxygen species (ROS) and lactate dehydrogenase (LDH), together with the up-regulation of cell inflammatory factors [interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), tumor necrotic factor-alpha (TNF-alpha)] and cell adhesion molecules [intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1)]. Silicon Dioxide 20-24 interleukin 6 Homo sapiens 211-224 32856282-10 2020 Median (interquartile range) darunavir CL/F was significantly lower in SARS-CoV-2 patients with IL-6 levels >= 18 pg/mL than in SARS-CoV-2 patients with IL-6 levels < 18 pg/mL or HIV patients (2.78 [2.16-4.47] vs. 7.24 [5.88-10.38] vs. 9.75 [8.45-13.79] L/h, respectively; p < 0.0001). Fluorine 42-43 interleukin 6 Homo sapiens 96-100 33202583-7 2020 MiR-23a-3p mimic transfection reversed ESAT6-induced reduction of reactive oxygen species generation, and augmented ESAT6-induced late apoptosis and phagocytosis, in association with down-regulations of the predicted target genes, including tumor necrosis factor (TNF)-alpha, TLR4, TLR2, IL6, IL10, Notch1, IL6R, BCL2, TGF-beta1, SP1, and IRF1. mir-23a-3p 0-10 interleukin 6 Homo sapiens 288-291 33152899-7 2020 In inactivated macrophages, u-QUE induced a proinflammatory state as observed by an increase in cellular proliferation; increased levels of oxidative molecules (nitric oxide and superoxide), protein levels, and gene overexpression of proinflammatory cytokines (IL-1beta, IL-6, and TNF-alpha); and decreased levels of IL-10, an anti-inflammatory cytokine. u-que 28-33 interleukin 6 Homo sapiens 271-275 33053467-4 2021 HUVECs exposed with SiO2 NPs generate excess amount of reactive oxygen species (ROS) and lactate dehydrogenase (LDH), together with the up-regulation of cell inflammatory factors [interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), tumor necrotic factor-alpha (TNF-alpha)] and cell adhesion molecules [intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1)]. Silicon Dioxide 20-24 interleukin 6 Homo sapiens 226-230 33456597-9 2020 Addition of synbiotic to allopurinol leads to a blood uric acid lowering (18.7% vs. 13.3%, p <0.01), CRP reduction (75% vs. 26.3%, p <0.01) as well as decrease of cytokines level: IL-1beta, IL-6, IL-8, IL-10 and TNFalpha (all p <0.001). Allopurinol 25-36 interleukin 6 Homo sapiens 190-194 33580734-9 2021 PBM reduced TNF-alpha, IL-1beta, IL-6, brain damage, neuroinflammation, and microglial activation, and it increased astroglial activity in peri-lesioned region after stroke. pbm 0-3 interleukin 6 Homo sapiens 33-37 32768575-10 2020 Inhibition of the IL-6/JAK/STAT3 pathway with the JAK1/2 specific inhibitor, AZD1480, reversed the associated increase of IL-6. AZD 1480 77-84 interleukin 6 Homo sapiens 18-22 32768575-10 2020 Inhibition of the IL-6/JAK/STAT3 pathway with the JAK1/2 specific inhibitor, AZD1480, reversed the associated increase of IL-6. AZD 1480 77-84 interleukin 6 Homo sapiens 122-126 32968431-6 2020 Isoflurane pretreatment decreased HR-induced IL-6 and IL-8 expression levels in A549 cells. Isoflurane 0-10 interleukin 6 Homo sapiens 45-49 32542535-7 2020 TBHP-stimulated IL-6 release was blocked by PD169316 but unaltered by indomethacin. 2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole 44-52 interleukin 6 Homo sapiens 16-20 33166496-4 2021 Primary human articular chondrocyte was employed as a model for in vitro assessment of IL-6 effects in cell viability, cellular oxidative stress and iron homeostasis by MTT, MDA, ROS and Iron Colorimetric assays. 3,4-Methylenedioxyamphetamine 174-177 interleukin 6 Homo sapiens 87-91 33149809-7 2020 IL6 secretion positively correlated with CDKN1a (p < 0.01), whereas EGCG could diminish both, IL6 and CDKN1a with the strongest effect (p < 0.01). epigallocatechin gallate 68-72 interleukin 6 Homo sapiens 94-97 32963704-12 2020 However, the inflammatory cytokines IL-6, TNF-alpha, and ICAM-1 in the DEX group were lower than those in the Con group after surgery (T2 to T4; P < 0.05). Dexmedetomidine 71-74 interleukin 6 Homo sapiens 36-40 33149809-10 2020 Activation of SIRT3 with EGCG correlated with lowered IL6 secretion significantly (p < 0.05) but not with anthocyanidin. epigallocatechin gallate 25-29 interleukin 6 Homo sapiens 54-57 32856282-7 2020 In SARS-CoV-2 patients (n = 30), interleukin (IL)-6 and body surface area were covariates associated with darunavir oral clearance (CL/F) and volume of distribution (Vd), respectively; no covariates were identified in HIV patients (n = 25). Fluorine 135-136 interleukin 6 Homo sapiens 33-51 32856282-9 2020 CART analysis found that an IL-6 level of 18 pg/mL may split the SARS-CoV-2 population in patients with low versus high darunavir CL/F (mean +- standard deviation 3.47 +- 1.90 vs. 8.03 +- 3.24 L/h; proportion of reduction in error = 0.46). Fluorine 133-134 interleukin 6 Homo sapiens 28-32 33333254-7 2021 The mean reduction rates at 7-10 days after treatment for serum interleukin-6 and interferon-gamma concentrations were greater in the thalidomide group compared to the controls. Thalidomide 134-145 interleukin 6 Homo sapiens 64-77 33101053-3 2020 In C2C12 myotubes differentiated at physiological glucose concentrations (5.5 mM), palmitate treatment (16 h) at concentrations greater than 250 muM increased release of ATP and inflammatory cytokines IL-6 and MIF, significantly blunted insulin and amino acid-induced signaling and reduced mitochondrial function. Palmitates 83-92 interleukin 6 Homo sapiens 201-205 32554275-9 2020 Toxicological results revealed that indoor and personal exposure to OC as well as PAH compounds and their derivatives (e.g., Alkyl-PAHs, Oxy-PAHs) induced cell viability reduction and increase in levels of LDH, IL-6, and 8-isoprostane. p-Aminohippuric Acid 82-85 interleukin 6 Homo sapiens 211-215 33584346-9 2021 In vivo experiments also showed that double knockout CD73 and ADORA2B remarkably improved CS-induced lung injury by activating PKC alpha, reducing the inflammatory cell number in bronchoalveolar lavage fluid and the production of inflammatory mediator IL-6, inhibiting the fibrosis-like lesions and decreasing collagen deposition surrounding bronchioles. Cesium 90-92 interleukin 6 Homo sapiens 252-256 31899473-10 2020 Plasma interleukin (IL)-6 (P = 0.02 and P = 0.01, respectively) and platelet aggregation reactivity in response to adenosine diphosphate (P = 0.002 and P = 0.035) were lower in the prasugrel compared to clopidogrel and ticagrelor group. prasugrel 181-190 interleukin 6 Homo sapiens 7-25 31899473-11 2020 CONCLUSION: As compared to ticagrelor and clopidogrel, therapy with prasugrel in patients undergoing stenting for an acute coronary syndrome is associated with improved endothelial function, stronger platelet inhibition, and reduced IL-6 levels, all of which may have prognostic implications. prasugrel 68-77 interleukin 6 Homo sapiens 233-237 32964957-12 2020 Moreover, relative levels of IL-6, IL-8, TNF-alpha, and MMP3/9/13 were significantly suppressed by SF1670 stimuli compared with IL-1beta group. SF1670 99-105 interleukin 6 Homo sapiens 29-33 32610185-5 2020 Additionally, TJ and siMyD88 significantly attenuated cell migration and invasion, inhibited EMT-like progression and reduced cytokine (IL-6, IL-8, TGF-beta1 and TNF-alpha) secretion induced by LPS. simyd88 21-28 interleukin 6 Homo sapiens 136-140 32920591-0 2020 Celastrol Inhibits Migration and Invasion of Triple-Negative Breast Cancer Cells by Suppressing Interleukin-6 via Downregulating Nuclear Factor-kappaB (NF-kappaB). celastrol 0-9 interleukin 6 Homo sapiens 96-109 32920591-5 2020 The expression of interleukin-6 (IL-6) was measured after transfection of short-hairpin RNA against IL-6 or celastrol treatment via quantitative real-time polymerase chain reaction, Western blot, or enzyme-linked immunosorbent analysis (ELISA). celastrol 108-117 interleukin 6 Homo sapiens 18-31 32920591-5 2020 The expression of interleukin-6 (IL-6) was measured after transfection of short-hairpin RNA against IL-6 or celastrol treatment via quantitative real-time polymerase chain reaction, Western blot, or enzyme-linked immunosorbent analysis (ELISA). celastrol 108-117 interleukin 6 Homo sapiens 33-37 33613982-5 2021 In addition, pro-inflammatory cytokine expressions of TNF-alpha and IL-6 induced by the binary mixture of Phe and Flu were all alleviated by co-treatment with PI3K/AKT and NF-kappaB specific inhibitors (LY294002 and BAY11-7082). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 203-211 interleukin 6 Homo sapiens 68-72 32920591-7 2020 The interaction between celastrol and NF-kappaB-mediated IL-6 was investigated by luciferase reporter assay. celastrol 24-33 interleukin 6 Homo sapiens 57-61 32920591-10 2020 Moreover, treatment with celastrol decreased IL-6 expression at mRNA and protein levels. celastrol 25-34 interleukin 6 Homo sapiens 45-49 32920591-11 2020 IL-6 overexpression mitigated celastrol-mediated suppression of cell migration and invasion. celastrol 30-39 interleukin 6 Homo sapiens 0-4 32920591-12 2020 Additionally, celastrol blocked the NF-kappaB pathway to inhibit IL-6 levels. celastrol 14-23 interleukin 6 Homo sapiens 65-69 32920591-13 2020 CONCLUSIONS Celastrol repressed migration and invasion through decreasing IL-6 levels by inactivation of NF-kappaB signaling in triple-negative breast cancer cells, providing a novel basis for use of celastrol in treating triple-negative breast cancer. celastrol 12-21 interleukin 6 Homo sapiens 74-78 32920591-13 2020 CONCLUSIONS Celastrol repressed migration and invasion through decreasing IL-6 levels by inactivation of NF-kappaB signaling in triple-negative breast cancer cells, providing a novel basis for use of celastrol in treating triple-negative breast cancer. celastrol 200-209 interleukin 6 Homo sapiens 74-78 33629550-8 2020 Conclusion: 100 mug/ml Nano-SiO2 combined with 31C cold exposure can synergistically reduce the activity of A549 cells and increase the expression level of inflammatory factors IL-6 and IL-8 . Silicon Dioxide 28-32 interleukin 6 Homo sapiens 177-181 33396129-4 2021 Treatment with NPs-Nd2O3 induced an inflammatory response in human bronchial epithelial cells (16HBE) by upregulating the expression of interleukin-6 (IL-6) and interleukin-8 (IL-8). nps-nd2o3 15-24 interleukin 6 Homo sapiens 136-149 32814718-4 2020 In humans, kynurenine strongly correlated with age, frailty status, TNF-alphaR1 and IL-6, weaker grip strength, and slower walking speed. Kynurenine 11-21 interleukin 6 Homo sapiens 84-88 32781843-6 2021 Furthermore, DDA and DTA showed strong anti-inflammatory effects in human macrophages differentiated from monocyte THP-1 cells through lowering the protein expression levels of pro-inflammatory cytokines interleukin-1beta (IL-1beta), interleukin-6 (IL-6), interferon gamma (IFN-gamma), monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor alpha (TNF-alpha). dda 13-16 interleukin 6 Homo sapiens 234-247 32712318-6 2020 By conducting overexpression and rescue experiments, overexpression of miR-340-5p was evidenced to inhibit proliferation and migration of pulmonary artery smooth muscle cells (PASMCs) and inflammation via reducing IL-1beta and IL-6 levels. mir-340-5p 71-81 interleukin 6 Homo sapiens 227-231 32781843-6 2021 Furthermore, DDA and DTA showed strong anti-inflammatory effects in human macrophages differentiated from monocyte THP-1 cells through lowering the protein expression levels of pro-inflammatory cytokines interleukin-1beta (IL-1beta), interleukin-6 (IL-6), interferon gamma (IFN-gamma), monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor alpha (TNF-alpha). dda 13-16 interleukin 6 Homo sapiens 249-253 33396129-4 2021 Treatment with NPs-Nd2O3 induced an inflammatory response in human bronchial epithelial cells (16HBE) by upregulating the expression of interleukin-6 (IL-6) and interleukin-8 (IL-8). nps-nd2o3 15-24 interleukin 6 Homo sapiens 151-155 33249060-5 2021 Consistent with known DHODH requirements for immunomodulatory cytokine production, PTC299 inhibited the production of interleukin (IL)-6, IL-17A (also called IL-17), IL-17 F, and vascular endothelial growth factor (VEGF) in tissue culture models. 6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole 83-89 interleukin 6 Homo sapiens 118-136 32376366-10 2020 Furthermore, we found that DoA could significantly inhibit IL-1beta-induced inflammation in SW982 human synovial cells, as evidenced by the decreased levels of pro-inflammatory mediators (TNF-alpha, IL-6 and COX-2) and MMP-3. dioctyl adipate 27-30 interleukin 6 Homo sapiens 199-203 32653013-9 2020 TAMs enhanced CRC cell proliferation and invasion via IL-6, and then activated the IL-6R/STAT3 pathway in CRC cells. tams 0-4 interleukin 6 Homo sapiens 54-58 32878107-4 2020 BCU decreased the serum concentration of IgG, IL-2, IFN-gamma, and IgA in DON treated piglets (p < 0.05), and promoted the serum concentration of IL-1beta, IgG, IL-2, IFN-gamma, IgA, IL-6, IgM, and TNFalpha in normal piglets (p < 0.05). (3r)-3,4-Dihydro-2h-Chromen-3-Ylmethanol 0-3 interleukin 6 Homo sapiens 183-187 32783751-8 2021 MeVac FmIL-12 also increased the expression of inflammatory cytokines (IFN-gamma, tumor necrosis factor alpha, and IL-6) both in vivo and in vitro. mevac fmil-12 0-13 interleukin 6 Homo sapiens 115-119 32781843-6 2021 Furthermore, DDA and DTA showed strong anti-inflammatory effects in human macrophages differentiated from monocyte THP-1 cells through lowering the protein expression levels of pro-inflammatory cytokines interleukin-1beta (IL-1beta), interleukin-6 (IL-6), interferon gamma (IFN-gamma), monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor alpha (TNF-alpha). diphtheria toxin fragment A 21-24 interleukin 6 Homo sapiens 234-247 32781843-6 2021 Furthermore, DDA and DTA showed strong anti-inflammatory effects in human macrophages differentiated from monocyte THP-1 cells through lowering the protein expression levels of pro-inflammatory cytokines interleukin-1beta (IL-1beta), interleukin-6 (IL-6), interferon gamma (IFN-gamma), monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor alpha (TNF-alpha). diphtheria toxin fragment A 21-24 interleukin 6 Homo sapiens 249-253 33168184-7 2021 The in vivo results showed that TVH-19 induced the formation of tertiary dentin, and reduced inflammation and apoptosis, as evident from the downregulated expression of interleukin 6 (IL-6) and cleaved-Caspase-3 (CL-CASP3). (3~{R})-4-chloranyl-3-(4-chlorophenyl)-3-[[1-(hydroxymethyl)cyclopropyl]methoxy]-2-[(4-nitrophenyl)methyl]isoindol-1-one 32-35 interleukin 6 Homo sapiens 169-182 32793904-5 2020 Consistent with known DHODH requirements for immunomodulatory cytokine production, PTC299 inhibited the production of interleukin (IL)-6, IL-17A (also called IL-17), IL-17F, and vascular endothelial growth factor (VEGF) in tissue culture models. 6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole 83-89 interleukin 6 Homo sapiens 118-136 32388485-5 2020 Longifolioside A significantly reduced the release of inflammatory cytokines such as interleukin (IL)-6, -8, and tumor necrosis factor (TNF)-alpha in LPS-stimulated THP-1 macrophages. Longifolioside A 0-16 interleukin 6 Homo sapiens 85-107 33168184-7 2021 The in vivo results showed that TVH-19 induced the formation of tertiary dentin, and reduced inflammation and apoptosis, as evident from the downregulated expression of interleukin 6 (IL-6) and cleaved-Caspase-3 (CL-CASP3). (3~{R})-4-chloranyl-3-(4-chlorophenyl)-3-[[1-(hydroxymethyl)cyclopropyl]methoxy]-2-[(4-nitrophenyl)methyl]isoindol-1-one 32-35 interleukin 6 Homo sapiens 184-188 32698260-5 2020 RESULTS: The significant effect of LEAA supplementation was inhibition of circulating IL-6 levels in the LEAA-treated group compared with the placebo group (P < .05). leaa 35-39 interleukin 6 Homo sapiens 86-90 32141102-5 2020 DBT was shown to decrease IL-1beta and IL-6 secretion from immune cells at higher concentrations while causing increases at lower concentrations. di-n-butyltin 0-3 interleukin 6 Homo sapiens 39-43 32698260-5 2020 RESULTS: The significant effect of LEAA supplementation was inhibition of circulating IL-6 levels in the LEAA-treated group compared with the placebo group (P < .05). leaa 105-109 interleukin 6 Homo sapiens 86-90 33832346-1 2021 This study monitored the changes in the expression of inflammatory IL-6 and IL-1beta during the treatment period of Fluoropyrimidine (FP) based therapy. 2-fluoropyrimidine 116-132 interleukin 6 Homo sapiens 67-71 32698260-9 2020 CONCLUSION: Our results revealed that LEAA supplementation before and after intense exercise could help reduce muscle soreness and IL-6 levels in wheelchair basketball players. leaa 38-42 interleukin 6 Homo sapiens 131-135 32141102-10 2020 The 24-h exposures to DBT decreased production of both IL-1beta and IL-6 at the two highest concentrations but increased production at lower concentrations. di-n-butyltin 22-25 interleukin 6 Homo sapiens 68-72 32454326-10 2020 We functionally challenged ovaries in vitro, by polyinosinic:polycytidylic acid (poly I:C) and LPS, known to activate TLR3 and TLR4, respectively, and found a tendency for increased IL-6 production, which was particular evident in the LPS-treated group. Poly C 61-79 interleukin 6 Homo sapiens 182-186 33249629-8 2021 In addition, Naringenin-loaded LCNs efficiently reduced the levels of pro-inflammatory markers, namely, IL-1beta, IL-6, TNF-alpha, and IL-8. lcns 31-35 interleukin 6 Homo sapiens 114-118 32559180-0 2020 COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status. Kynurenine 26-36 interleukin 6 Homo sapiens 81-85 32595600-8 2020 We report that palmitate altered Nampt, Bmal1, Per2 and the inflammatory genes Nf-kappab, IkappaBalpha, Il-6, and Tlr4. Palmitates 15-24 interleukin 6 Homo sapiens 104-108 32595496-5 2020 SB216763 and Nec-1 also decreased levels of inflammatory related cytokines, including interleukin-6 (IL-6), interleukin-1 beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha). SB 216763 0-8 interleukin 6 Homo sapiens 86-99 32996080-9 2021 The levels of inflammatory factors (TNF-alpha, IL-1beta, and IL-6) were elevated in DPN model. dpn 84-87 interleukin 6 Homo sapiens 61-65 32595496-5 2020 SB216763 and Nec-1 also decreased levels of inflammatory related cytokines, including interleukin-6 (IL-6), interleukin-1 beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha). SB 216763 0-8 interleukin 6 Homo sapiens 101-105 32219875-7 2020 DSR-6434 triggered 20-fold lower levels of IFN-alpha by pDCs, but higher production of IL-6, IL-8 and TNF, compared to RNA-IC. DSR-6434 0-8 interleukin 6 Homo sapiens 87-91 32238729-4 2020 Administration of steroid and high-dose intravenous immunoglobulin (1 g/kg) did not alleviate fever or reduce cytokine production; however, after administration of etoposide (an antineoplastic agent), fever decreased immediately, the patient"s general condition improved, and levels of IL-6, IL-10, IL-8, MCP-1, IFN-gamma, and TNF-alpha declined after etoposide administration. Etoposide 164-173 interleukin 6 Homo sapiens 286-290 33356884-6 2021 Nicaraven suppressed TNFalpha-induced mRNA expression of multiple adhesion molecules and pro-inflammatory cytokines, including VCAM-1, ICAM-1, E-selectin, MCP-1, TNFalpha, IL-1beta, IL-6 and IL-8. nicaraven 0-9 interleukin 6 Homo sapiens 182-186 33167097-8 2020 Compared with the blank control group, the content of autophagosome and the content of IL-6 in the oxymatrine group and the combination group were also decreased significantly (P<0.01). oxymatrine 99-109 interleukin 6 Homo sapiens 87-91 32525823-9 2020 The increased activities of TNFalpha, IL-1beta and IL-6 induced by CSE were partially attenuated by Dex. Dexmedetomidine 100-103 interleukin 6 Homo sapiens 51-55 33092789-5 2020 TAMs increase EZH2 stability by stimulating PRMT1-mediated meR342-EZH2 formation through the secretion of interleukin-6 (IL-6) cytokine. tams 0-4 interleukin 6 Homo sapiens 106-119 32290492-2 2020 The algal meroterpenoids (AMTs) 1-8 were tested for their inhibitory effects on the production of the pro-inflammatory cytokines tumor necrosis factor (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta), and the expression of cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) in LPS-stimulated THP-1 human macrophages. amts 26-30 interleukin 6 Homo sapiens 164-177 32001222-6 2020 EGCG priming alleviated the detrimental effects of thermal stress in hWJMSCs as observed by significant down-regulation in expression of BCL2 associated X (BAX), interleukin 6 (IL6), and interleukin 1 beta (IL1beta) genes, while proliferating cell nuclear antigen (PCNA), BCL2 like 1 (BCL2L1), vascular endothelial growth factor (VEGF), transforming growth factor beta 1 (TGFbeta1), hepatocyte growth factor (HGF) and interleukin 4 (IL4) genes were up-regulated. epigallocatechin gallate 0-4 interleukin 6 Homo sapiens 162-175 32760206-7 2020 The drugs triciribine and kinetin riboside activate ACE2 expression or inhibit IL-6 production in macrophages to some extent. triciribine 10-21 interleukin 6 Homo sapiens 79-83 32615160-12 2020 In addition, combining bergenin and dexamethasone (DEX) yielded additive effects on the reduction of IL-6 and IL-8 expression. bergenin 23-31 interleukin 6 Homo sapiens 101-105 32345003-1 2020 The aim of this study was to explore the role of IL-6-miR-210 in the regulation of Tregs function and atrial fibrosis in atrial fibrillation (AF). tregs 83-88 interleukin 6 Homo sapiens 49-53 32001222-6 2020 EGCG priming alleviated the detrimental effects of thermal stress in hWJMSCs as observed by significant down-regulation in expression of BCL2 associated X (BAX), interleukin 6 (IL6), and interleukin 1 beta (IL1beta) genes, while proliferating cell nuclear antigen (PCNA), BCL2 like 1 (BCL2L1), vascular endothelial growth factor (VEGF), transforming growth factor beta 1 (TGFbeta1), hepatocyte growth factor (HGF) and interleukin 4 (IL4) genes were up-regulated. epigallocatechin gallate 0-4 interleukin 6 Homo sapiens 177-180 33092789-5 2020 TAMs increase EZH2 stability by stimulating PRMT1-mediated meR342-EZH2 formation through the secretion of interleukin-6 (IL-6) cytokine. tams 0-4 interleukin 6 Homo sapiens 121-125 32001222-7 2020 Accompanying gene expression data, EGCG primed cells exposed to heat stress also exhibited remarkably increased secretion of VEGF, HGF, epidermal growth factor (EGF), stromal-derived factor 1 (SDF1) proteins while the reduced release of IL-6, and tumor necrosis factor-alpha (TNF-alpha) proteins. epigallocatechin gallate 35-39 interleukin 6 Homo sapiens 237-241 33218476-2 2020 Herein, an immunosensor has been developed for monitoring IL-6, which is fabricated by Au nanoparticles (Au NPs)-thionine (THI)-carboxylated multi walled carbon nanotubes (CMWCNTs) as the substrate with high conductivity. thionine 113-121 interleukin 6 Homo sapiens 58-62 32528938-6 2020 Comparison of this effects on malignant (Caco-2, HCT116) and non-malignant (MSC, HSF) cells suggests the selective cytotoxic and genotoxic activity of prodigiosin-HNTs nanoformulation. prodigiosin-hnts 151-167 interleukin 6 Homo sapiens 81-84 31776889-4 2020 Using human THP-1 macrophage, we first confirmed that incorporation of PNA into cellular phospholipids suppressed the production of interleukin-6 (IL-6) (by 46%), tumor necrosis factor-alpha (TNF-alpha) (by 18%), and prostaglandin E2 (PGE2) (by 87%), and the expression of type-2 cyclooxygenase (COX-2) (by 27%). 5,9,12-octadecatrienoic acid 71-74 interleukin 6 Homo sapiens 132-145 32528464-7 2020 Incubation of healthy and SSc dendritic cells with etoposide, a carnitine transporter inhibitor, inhibited the production of pro-inflammatory cytokines such as IL-6 through inhibition of fatty acid oxidation. Etoposide 51-60 interleukin 6 Homo sapiens 160-164 33218476-2 2020 Herein, an immunosensor has been developed for monitoring IL-6, which is fabricated by Au nanoparticles (Au NPs)-thionine (THI)-carboxylated multi walled carbon nanotubes (CMWCNTs) as the substrate with high conductivity. thionine 123-126 interleukin 6 Homo sapiens 58-62 31776889-4 2020 Using human THP-1 macrophage, we first confirmed that incorporation of PNA into cellular phospholipids suppressed the production of interleukin-6 (IL-6) (by 46%), tumor necrosis factor-alpha (TNF-alpha) (by 18%), and prostaglandin E2 (PGE2) (by 87%), and the expression of type-2 cyclooxygenase (COX-2) (by 27%). 5,9,12-octadecatrienoic acid 71-74 interleukin 6 Homo sapiens 147-151 33324092-10 2020 Intraarticular injection of the IFX-loaded F127-HA-PGA hydrogel could alleviate the expression of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and interleukin-17 (IL-17), in the synovial fluid and cartilage as well as relieve pain and inhibit cartilage destruction in RA. f127-ha-pga 43-54 interleukin 6 Homo sapiens 201-214 32336102-7 2020 With almost equal surface content of PSBMA, the PSBMA-PDA-PP exhibited a more superior ability against macrophages adhesion and proliferation, and showed more significantly decreased releases of TNF-alpha and IL-6 (p < 0.05) than those of PSBMA@PDA-PP, fundamentally attributed to its more neutral surface potential and the protection for polyphenols of PDA from oxidation with PSBMA as the outer-layer. psbma-pda-pp 48-60 interleukin 6 Homo sapiens 209-213 31587475-6 2020 SA similarly increased inflammatory reactions by increasing the level of interleukin-6, tumor necrosis factor-alpha, and interleukin-1beta. sodium arsenite 0-2 interleukin 6 Homo sapiens 73-115 33324092-10 2020 Intraarticular injection of the IFX-loaded F127-HA-PGA hydrogel could alleviate the expression of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and interleukin-17 (IL-17), in the synovial fluid and cartilage as well as relieve pain and inhibit cartilage destruction in RA. f127-ha-pga 43-54 interleukin 6 Homo sapiens 216-220 32931773-7 2020 Consistent with these results, CyM diminished the expression of inflammatory genes (COX-2, TNF-alpha, IL-1beta, and IL-6), AP-1-Luc activity, and phosphorylation of Ras-mediated signaling enzymes in Ras-overexpressing HEK 293 cells. cysmethynil 31-34 interleukin 6 Homo sapiens 116-120 32222695-11 2020 In vitro experiments indicated that DOP increased the LO2 cell viability; prevented LDH release prominently; reduced the secretion of IL-1beta, IL-6, and TNF-alpha; and reversed the expression of IL-1beta, IL-6, TNF-alpha, caspase 1, NLRP3, p-NF-kappaB, and TLR4. Diethylhexyl Phthalate 36-39 interleukin 6 Homo sapiens 144-148 32222695-11 2020 In vitro experiments indicated that DOP increased the LO2 cell viability; prevented LDH release prominently; reduced the secretion of IL-1beta, IL-6, and TNF-alpha; and reversed the expression of IL-1beta, IL-6, TNF-alpha, caspase 1, NLRP3, p-NF-kappaB, and TLR4. Diethylhexyl Phthalate 36-39 interleukin 6 Homo sapiens 206-210 32223187-6 2020 In addition, silica increased the expression of interleukin 1 beta (IL-1beta), interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha), and T3 treatment reduced those pro-inflammatory cytokines secretion. Silicon Dioxide 13-19 interleukin 6 Homo sapiens 79-92 32223187-6 2020 In addition, silica increased the expression of interleukin 1 beta (IL-1beta), interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha), and T3 treatment reduced those pro-inflammatory cytokines secretion. Silicon Dioxide 13-19 interleukin 6 Homo sapiens 94-98 32511571-0 2020 COVID-19 infection results in alterations of the kynurenine pathway and fatty acid metabolism that correlate with IL-6 levels and renal status. Kynurenine 49-59 interleukin 6 Homo sapiens 114-118 33059990-12 2020 CONCLUSIONS: Serum IL-6 level immediately after ROSC was a highly specific and sensitive marker for the 3-month poor neurologic outcome, and may be a useful early predictive marker of neurologic outcome in OHCA survivors treated with TTM. ttm 234-237 interleukin 6 Homo sapiens 19-23 32574262-7 2020 Treatment with IFN-alpha2b with or without arbidol significantly reduced the duration of detectable virus in the upper respiratory tract and in parallel reduced duration of elevated blood levels for the inflammatory markers IL-6 and CRP. umifenovir 43-50 interleukin 6 Homo sapiens 224-228 31999881-5 2020 mRNA expression of the pro-inflammatory cytokine TNF-alpha, IL-1beta and IL-6 was decreased significantly in ECG- and EGCG-treated HDPCs. epigallocatechin gallate 118-122 interleukin 6 Homo sapiens 73-77 32851338-11 2020 However, the increases of NF-kappaB, TNF-alpha, IL-6, S-100beta and NSE levels were significantly smaller in the dexmedetomidine groups than those in the control group (P < 0.017). Dexmedetomidine 113-128 interleukin 6 Homo sapiens 48-52 31989795-6 2020 Sodium tanshinone IIA sulfonate decreased the levels of inflammatory factors (IL-1beta, IL-6 and TNF-alpha) in the SH-SY5Y cells. tanshinone II A sodium sulfonate 0-31 interleukin 6 Homo sapiens 88-92 32346326-0 2020 Spiroindolone analogues bearing benzofuran moiety as a selective cyclooxygenase COX-1 with TNF-alpha and IL-6 inhibitors. spiroindolone 0-13 interleukin 6 Homo sapiens 105-109 32407476-7 2020 The level of EBC soluble cluster of differentiation-40 ligand in COPD group increased after inhalation (1.07-1.16 pg/mL, P = 0.031), while IL-4 and IL-6 levels in EBC were significantly lower after inhalation in the COPD (0.80-0.64 pg/mL, P = 0.025) and asthma (0.06-0.05 pg/mL, P = 0.007) group, respectively. NSC638702 163-166 interleukin 6 Homo sapiens 148-152 32301466-6 2020 The interaction of interleukin 6 with the antibodies produces a blue-shift in resonant wavelength and the reflectance intensity increases up to 50% and 44% when tested with CoF & magnetite based MPC respectively at a concentration of 50 pg ml-1. Ferrosoferric Oxide 179-188 interleukin 6 Homo sapiens 19-32 32041250-6 2020 Moreover, inflammatory responses induced by gamma irradiation, as demonstrated by increased levels of IL-6, TNF-alpha, and IL-1beta, were also blocked by celastrol. celastrol 154-163 interleukin 6 Homo sapiens 102-106 32666334-12 2020 CONCLUSION: In individuals requiring orthognathic surgery, depression, TMD, and genetic polymorphisms in IL6 contribute to negative impact on OHRQoL. ohrqol 142-148 interleukin 6 Homo sapiens 105-108 32158309-9 2020 The levels of EBC IL-6 in obese and non-obese group were found as 22.61+-12.53 and 21.08+-14.39, respectively (p=0.624). NSC638702 14-17 interleukin 6 Homo sapiens 18-22 32290603-4 2020 The results demonstrated that KC dose-dependently suppressed the production of inflammatory mediators, including NO, PGE2, IL-6, IL1beta, MCP-1, and IFN-beta in LPS-stimulated RAW264.7 macrophages. lysylcysteine 30-32 interleukin 6 Homo sapiens 123-127 33224259-5 2020 In the present study, we aim to investigate the anti-inflammatory mechanisms associated with the effects of RTA-B in RAW264.7 macrophages and LO2 cells by detecting cell viabilities, nitric oxide (NO) production, tumour necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) production. rta-b 108-113 interleukin 6 Homo sapiens 259-272 32278133-9 2020 Furthermore, IL-37 promoted TAMs polarization from M2 to M1 subtype through inhibiting the IL-6/STAT3 signaling. tams 28-32 interleukin 6 Homo sapiens 91-95 31372914-6 2020 While conventional amphotericin B further increased IL-6 and to a smaller extent IL-8 levels, this was not the case for its liposomal formulation. Amphotericin B 19-33 interleukin 6 Homo sapiens 52-56 33224259-5 2020 In the present study, we aim to investigate the anti-inflammatory mechanisms associated with the effects of RTA-B in RAW264.7 macrophages and LO2 cells by detecting cell viabilities, nitric oxide (NO) production, tumour necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) production. rta-b 108-113 interleukin 6 Homo sapiens 274-278 32070866-7 2020 Palmitate also induced apoptosis and mRNA expression of IL-6 and IL-8 in the PDLSCs. Palmitates 0-9 interleukin 6 Homo sapiens 56-60 33174867-5 2020 Our findings indicate that pretreatment with memantine significantly reduced the expression of interleukin (IL)-6 and IL-8, which are both serum markers if AMI severity. Memantine 45-54 interleukin 6 Homo sapiens 95-113 32079428-8 2020 Significantly lower ISI, HADS, HADS-A, and HADS-D scores, but higher 1/mean reaction time (1/mRT) score, were found in shift nurses treated with SMG than in those who received placebo, and these effects were associated with changes in salivary melatonin, TNF, IL-1beta, and IL-6 levels. N-SUCCINYL METHIONINE 145-148 interleukin 6 Homo sapiens 274-278 32350151-0 2020 The influence of retinol concentration in liquid crystal formula on epidermal growth factor, interleukin-6 and transglutaminase-1 mRNA expression in the epidermis. Vitamin A 17-24 interleukin 6 Homo sapiens 93-106 32005256-9 2020 Our further findings revealed that treatment with SR9009 inhibited NLRP3 inflammasome activation, inflammatory cytokine (IL-1beta, IL-18, IL-6, and TNF-alpha) production, astrocytosis, microgliosis, and neuronal damage in the hippocampus after SE. SR9009 50-56 interleukin 6 Homo sapiens 138-142 32623680-9 2020 Serum interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) showed significant (P < 0.05) decrease in nanoselenium supplemented group compared with other groups. nanoselenium 113-125 interleukin 6 Homo sapiens 6-19 31693828-0 2020 Resolvin D5, a lipid mediator, inhibits production of interleukin-6 and CCL5 via the ERK-NF-kappaB signaling pathway in lipopolysaccharide-stimulated THP-1 cells. resolvin D5 0-11 interleukin 6 Homo sapiens 54-67 31506572-4 2020 We showed that isosibiricin (10-50 muM) dose-dependently inhibited lipopolysaccharide (LPS)-induced BV-2 microglia activation, evidenced by the decreased expression of inflammatory mediators, including nitrite oxide (NO), tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1beta (IL-1beta) and interleukin-18 (IL-18). Isosibiricin 15-27 interleukin 6 Homo sapiens 264-277 31506572-4 2020 We showed that isosibiricin (10-50 muM) dose-dependently inhibited lipopolysaccharide (LPS)-induced BV-2 microglia activation, evidenced by the decreased expression of inflammatory mediators, including nitrite oxide (NO), tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1beta (IL-1beta) and interleukin-18 (IL-18). Isosibiricin 15-27 interleukin 6 Homo sapiens 279-283 31693828-8 2020 Resolvin D5 inhibited the LPS-stimulated phosphorylation of ERK and translocation of p65 and p50 into the nucleus, resulting in the inhibition of IL-6 and CCL5 production. resolvin D5 0-11 interleukin 6 Homo sapiens 146-150 32623680-9 2020 Serum interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) showed significant (P < 0.05) decrease in nanoselenium supplemented group compared with other groups. nanoselenium 113-125 interleukin 6 Homo sapiens 21-25 32769069-7 2020 EGCG has been shown to prevent production and mRNA expression of TSLP, interleukin (IL)-1beta, IL-6, and IL-8 by RANKL without cytotoxicity. epigallocatechin gallate 0-4 interleukin 6 Homo sapiens 95-99 31979305-0 2020 The Impact of Coconut Oil and Epigallocatechin Gallate on the Levels of IL-6, Anxiety and Disability in Multiple Sclerosis Patients. epigallocatechin gallate 30-54 interleukin 6 Homo sapiens 72-76 31979305-2 2020 Epigallocatechin gallate (EGCG) decreases IL-6, which could be enhanced by the anti-inflammatory effect of high ketone bodies after administering coconut oil (both of which are an anxiolytic). epigallocatechin gallate 0-24 interleukin 6 Homo sapiens 42-46 31979305-2 2020 Epigallocatechin gallate (EGCG) decreases IL-6, which could be enhanced by the anti-inflammatory effect of high ketone bodies after administering coconut oil (both of which are an anxiolytic). epigallocatechin gallate 26-30 interleukin 6 Homo sapiens 42-46 31979305-3 2020 Therefore, the aim of this study was to assess the impact of coconut oil and EGCG on the levels of IL-6, anxiety and functional disability in patients with MS. METHODS: A pilot study was conducted for four months with 51 MS patients who were randomly divided into an intervention group and a control group. epigallocatechin gallate 77-81 interleukin 6 Homo sapiens 99-103 31836387-0 2020 1,3-Dicaffeoylquinic acid targeting 14-3-3 tau suppresses human breast cancer cell proliferation and metastasis through IL6/JAK2/PI3K pathway. 1,3-dicaffeoylquinic acid 0-25 interleukin 6 Homo sapiens 120-123 32162384-5 2020 Treatment with teneligliptin significantly reduced IL-1beta-induced expression of tumor necrosis factor alpha, IL-6, and IL-8, generation of reactive oxygen species, increase in metalloproteinase 3 (MMP-3) and MMP-13, reduction of tissue inhibitors of matrix metalloproteinase 1 (TIMP-1) and TIMP-2, release of lactate dehydrogenase, and activation of the mitogen-activated protein kinase p38 and nuclear factor kappaB intracellular signaling pathways, among other things. 3-(4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-ylcarbonyl)thiazolidine 15-28 interleukin 6 Homo sapiens 111-115 31955966-10 2020 Based on 5 effect sizes from 4 studies, we found a statistically significant reduction in serum IL-6 concentration after atorvastatin therapy (WMD, -0.44; 95% CI, -0.65 to -0.22; I2 = 93.9%). atorvastatin 121-133 interleukin 6 Homo sapiens 96-100 31955966-13 2020 Atorvastatin therapy might also help to decrease serum IL-6 concentration in these patients. atorvastatin 0-12 interleukin 6 Homo sapiens 55-59 31789424-9 2020 In addition, ASB activated the production of Nrf2 and increased the mRNA expression levels of glutamate-cysteine ligase catalytic subunit and NAD(P)H quinone oxidoreductase 1, while ASB downregulated the protein expression of p65 and decreased the production of interleukin (IL)-1beta, IL-6 and tumor necrosis factor-alpha. sodium sulfate 13-16 interleukin 6 Homo sapiens 286-322 31441374-5 2020 Chronic NDE biomarker levels in subjects without TBI showed significantly higher levels of PrPc, synaptogyrin-3, P-T181-tau and Abeta42, but not P-S396-tau and IL-6, in those with CI compared to controls without CI. NDE 8-11 interleukin 6 Homo sapiens 160-164 31533605-0 2020 Synergism effects of ursolic acid supplementation on the levels of irisin, C-reactive protein, IL-6, and TNF-alpha during high-intensity resistance training in low activity men. ursolic acid 21-33 interleukin 6 Homo sapiens 95-99 31533605-9 2020 UA treatment also dramatically decreased the plasma levels of CRP, IL-6, and TNF-alpha in the HIRT+UA group versus the HIRT+P group (p<0.05). ursolic acid 0-2 interleukin 6 Homo sapiens 67-71 31533605-10 2020 CONCLUSION: The current data showed that UA-induced an increase in serum irisin and reduction of CRP, IL-6, and TNF-alpha may have beneficial effects as a chemical for increasing of the effects of HIRT in low activity men. ursolic acid 41-43 interleukin 6 Homo sapiens 102-106 32603665-10 2020 Moreover, the induction of IKBKE by TAMs in TNBC cells was identified to be associated with STAT3 signaling, which was activated by TAM-secreted IL-6 and IL-10. tams 36-40 interleukin 6 Homo sapiens 145-149 31106593-6 2019 Furthermore, salicin inhibits IL-1beta-induced production of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1), vascular adhesion molecules such as intercellular cell adhesion molecule-1 (iCAM-1) and vascular cell adhesion molecule 1 (VCAM-1), and high-mobility group protein 1 (HMGB-1). salicin 13-20 interleukin 6 Homo sapiens 137-150 31106593-6 2019 Furthermore, salicin inhibits IL-1beta-induced production of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1), vascular adhesion molecules such as intercellular cell adhesion molecule-1 (iCAM-1) and vascular cell adhesion molecule 1 (VCAM-1), and high-mobility group protein 1 (HMGB-1). salicin 13-20 interleukin 6 Homo sapiens 152-156 31929574-8 2020 Similarly, hesperidin also improved the serum and tissue levels of leptin, interleukin-6 and tumor necrosis factor-alpha more significantly (P<0.05) when compared with that of orlistat. Hesperidin 11-21 interleukin 6 Homo sapiens 75-88 32394288-7 2020 We found dexmedetomidine reduced LPS-induced IL-6 and TNF-alpha production and increase Arg1 in primary microglia. Dexmedetomidine 9-24 interleukin 6 Homo sapiens 45-49 30648524-8 2020 Serum IL-6 was significantly reduced (by 9%, P=0.001) after GH+CS, and satisfied the FDR<0.05 threshold. Cesium 63-65 interleukin 6 Homo sapiens 6-10 30648524-10 2020 CONCLUSION: The results of this study using samples from a previously conducted trial in OA patients, demonstrate that GH+CS reduces circulating IL-6, an inflammatory cytokine, but is otherwise comparable to celecoxib with regard to effects on other circulating protein biomarkers. Cesium 122-124 interleukin 6 Homo sapiens 145-149 31668347-5 2019 DEX infusion during the perioperative period inhibited release of epinephrine, norepinephrine, and cortisol; decreased blood glucose, interleukin (IL)-6, tumour necrosis factor-alpha, and C-reactive protein; and increased interleukin-10 in surgical patients. Dexmedetomidine 0-3 interleukin 6 Homo sapiens 134-152 33107903-7 2020 Furthermore, fursultiamine suppressed LPS-induced upregulation of IL-6, IL-8, and monocyte chemoattractant protein-1 in a dose-dependent and time-dependent manner in primary hRPE cells. Fursultiamin 13-26 interleukin 6 Homo sapiens 66-70 31764352-4 2019 QUESTIONS/PURPOSES: Using human OA knee chondrocytes in vitro, we asked, does chloramphenicol (1) activate autophagy in chondrocytes; (2) protect chondrocytes from IL-1beta-induced apoptosis; and (3) reduce the expression of matrix metallopeptidase (MMP)-13 and IL-6 (markers associated with articular cartilage degradation and joint inflammation). Chloramphenicol 78-93 interleukin 6 Homo sapiens 262-266 31106659-5 2020 In addition, serum level of IL-6 was decreased significantly in omega-3, vitamin D3, and cosupplementation groups compared with baseline. Fatty Acids, Omega-3 64-71 interleukin 6 Homo sapiens 28-32 32678677-11 2020 Compared with the baseline, CGM-GLN produced 54.52%, 59.08%, and 22.03% reduction in IL-1beta, IL-6, and sVCAM levels, respectively. cgm-gln 28-35 interleukin 6 Homo sapiens 95-99 33198933-7 2020 After 6 h incubation with MMC, both HCAEC and HITAEC displayed a decrease in IL8 concentration and the mRNA level of IL6 and IL8 compared to control cells. Mitomycin 26-29 interleukin 6 Homo sapiens 117-120 33198933-10 2020 These findings suggest that the MMC-induced genotoxic stress in endothelial cells derived from different arteries is associated with differential secretion and gene expression of proinflammatory cytokines IL6 and IL8. Mitomycin 32-35 interleukin 6 Homo sapiens 205-208 31610186-4 2019 Among the 17 flavonoids tested, only apigenin (flavones), luteolin (flavones), daidzein (isoflavones) and genistein (isoflavones) reduced LPS-induced release of inflammatory cytokines/chemokines interleukin (IL)-6, IL-8 and monocyte chemoattractant protein-1 in BEAS-2B cells. Genistein 106-115 interleukin 6 Homo sapiens 195-213 31578786-8 2019 The secretion of SASP components, including interleukin (IL)-8, IL-6, and C-C motif chemokine ligand 2 was also substantially reduced in the presence of PC. Phosphatidylcholines 153-155 interleukin 6 Homo sapiens 64-68 31520180-9 2019 The secreted levels of IL-8, TNF-alpha, IL-6 and IL-17A induced by silica particles were also significantly lower from CTGF siRNA-transfected cells than that from normal 16HBE cells (P < 0.05). Silicon Dioxide 67-73 interleukin 6 Homo sapiens 40-44 32678677-12 2020 Whereas CHN-GLN group of subjects expressed only 23.17%, 21.38%, and 6.82% reduction in IL-1beta, IL-6, and sVCAM levels, respectively. Glutamine 12-15 interleukin 6 Homo sapiens 98-102 32897647-11 2020 miR-141-3p also inhibited the expressions of IL-6, IL-beta, TNF-alpha and Keap1 but promoted the expressions of Nrf2 and HO-1. mir-141-3p 0-10 interleukin 6 Homo sapiens 45-49 31631580-8 2019 Moreover, nevirapine significantly decreased the expression of IL-6 mRNA and phosphorylation of JAK2 (Y1007+Y1008) and STAT3 (Tyr 705) in WRO 82-1 cells compared with those in control cells. Nevirapine 10-20 interleukin 6 Homo sapiens 63-67 31631580-9 2019 CONCLUSION: Our findings suggest that nevirapine significantly repressed migration and invasion/metastasis in WRO 82-1 cells and tumor xenografts, which may be related to inhibition of IL-6/STAT3 signaling pathway. Nevirapine 38-48 interleukin 6 Homo sapiens 185-189 31829277-15 2019 In human studies, dexmedetomidine reduced CRP (4 studies), TNFalpha (5 studies), IL-6 (6 studies), IL-1beta (3 studies), and altered several other mediators. Dexmedetomidine 18-33 interleukin 6 Homo sapiens 81-85 31520180-7 2019 The secretions of IL-8, TNF-alpha, IL-6 and IL-17A were also significantly increased by silica particles (P < 0.05). Silicon Dioxide 88-94 interleukin 6 Homo sapiens 35-39 32998161-11 2020 In presence of IL-1beta, TCs showed an upregulation of ADORA2A, SCX and COL3A1 expression and an increase of IL-6, IL-8, PGE2 and VEGF secretion. 9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide 25-28 interleukin 6 Homo sapiens 109-113 31525567-8 2019 CONCLUSIONS: These data provide evidence of a biological link between metabolites of the kynurenine pathway, the endocannabinoid system and IL-6 and suggest that these factors may influence personality traits. Kynurenine 89-99 interleukin 6 Homo sapiens 140-144 31730488-11 2019 Conditioned medium of IPTD-MSCs treated with a combination of DMOG and TNF-alpha contained higher levels of pro-angiogenic (VEGF, IL-6, and IL-8) compared to controls, promoting angiogenesis of human endothelial cells in vitro. dimethyloxallyl glycine 62-66 interleukin 6 Homo sapiens 130-134 31714459-8 2022 A significant correlation was observed between pre-post variations of IL-6 and GSH/GSSG ratio in plasma (p < 0.0001), which reinforces the integration between oxidative stress and inflammation during MMA combats. Glutathione Disulfide 83-87 interleukin 6 Homo sapiens 70-74 32400228-8 2020 The adjusted OR for 1SD increase in log-CRP and log-IL-6 was 0.96 (95%CI 0.85, 1.08) and 1.09 (95%CI 0.97, 1.22), respectively. CHEMBL569412 20-23 interleukin 6 Homo sapiens 52-56 30997931-9 2019 Apparently, VCZ may have an inhibitory effect on IL-6 levels. Voriconazole 12-15 interleukin 6 Homo sapiens 49-53 31827916-10 2019 MMC also reduced the expression of inflammatory factors TGF-beta1, VEGF, and IL-6. Mitomycin 0-3 interleukin 6 Homo sapiens 77-81 32764328-3 2020 EBC concentrations of interleukin (IL)-6, IL-8, IL-15, TNF-alpha and VEGF-A were assessed with ELISA and compared at baseline and after six months of pirfenidone treatment. NSC638702 0-3 interleukin 6 Homo sapiens 22-40 31323583-7 2019 We found that DEHP at the indicated concentration plus 50.00muM BaP increased cellular and mitochondrial ROS levels, IL-6 and IL-8 secretions at 24 and 48h as well as MDA levels and GSH-Px activities at 48h, compared to the solvent control. Diethylhexyl Phthalate 14-18 interleukin 6 Homo sapiens 117-121 30947576-0 2019 ERK-dependent IL-6 positive feedback loop mediates resistance against a combined treatment using danusertib and BKM120 in Burkitt lymphoma cell lines. NVP-BKM120 112-118 interleukin 6 Homo sapiens 14-18 32756329-4 2020 In addition, the PBL paste and sauce extracts significantly lowered the level of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, which are biomarkers of inflammation, and significantly increased the inhibition rate of superoxide dismutase (SOD) and reduced glutathione (GSH), which are antioxidative indicators, in proportion to the amount of PBL added to the paste and sauce. Pentane-2,2,4,4-Tetrol 17-20 interleukin 6 Homo sapiens 119-137 31411318-5 2019 In this study, we treated hESCs with lipopolysaccharide (LPS) and found that LPS treatment increased the mRNA levels of pro-inflammatory cytokines, such as interleukin (IL)-1beta, IL-6, IL-8, IL-18, and TNFalpha, and the secretion of IL-6. hescs 26-31 interleukin 6 Homo sapiens 180-184 31411318-5 2019 In this study, we treated hESCs with lipopolysaccharide (LPS) and found that LPS treatment increased the mRNA levels of pro-inflammatory cytokines, such as interleukin (IL)-1beta, IL-6, IL-8, IL-18, and TNFalpha, and the secretion of IL-6. hescs 26-31 interleukin 6 Homo sapiens 234-238 30861304-2 2019 Previously, we have shown that silica nanoparticles sized 50 nm (Si50) induce release of CXCL8 and IL-6 from BEAS-2B cells, via mechanisms involving NFkappaB, p38 MAP kinase and TGF-alpha-activated EGF receptor. Silicon Dioxide 31-37 interleukin 6 Homo sapiens 99-103 31725602-7 2019 The pooled analysis showed that a significant decrease in hsCRP (MD = -0.57, [95%CI -1.12 to -0.02, P = .04]) and IL-6 (MD = 1.48,[95%CI 0.39 to 2.56, P = .008]) was observed in the sarpogrelate treatment. sarpogrelate 182-194 interleukin 6 Homo sapiens 114-118 32312453-0 2020 Highly sensitive impedimetric immunosensor for determination of interleukin 6 as a cancer biomarker by using conjugated polymer containing epoxy side groups modified disposable ITO electrode. Polymers 120-127 interleukin 6 Homo sapiens 64-77 31604428-7 2019 Dexmedetomidine added to ropivacaine for transversus abdominis plane block significantly reduced serum levels of cortisol, norepinephrine, epinephrine, interleukin-6, blood glucose, mean arterial pressure and heart rate in a dose-dependent manner (P < 0.05), accompanied with decreased anesthetic and opioid consumption during the operation (P < 0.05), but the high dose of dexmedetomidine induced higher incidences of bradycardia than low or medium dose of dexmedetomidine (P < 0.05). Dexmedetomidine 0-15 interleukin 6 Homo sapiens 152-165 31957703-8 2019 Dex reduced TNF-alpha, IL-6, IL-1beta, ROS, and MDA production, whereas it increased that of SOD and GSH-Px in OGD/R-treated WRL-68 cells. Dexmedetomidine 0-3 interleukin 6 Homo sapiens 23-27 31957703-10 2019 Knockdown of Nrf2 reversed the Dex effects on cell proliferation, apoptosis, and expression of TNF-alpha, IL-6, IL-1beta, ROS, MDA, SOD, and GSH-Px. Dexmedetomidine 31-34 interleukin 6 Homo sapiens 106-110 32312453-1 2020 A novel impedimetric immunosensor based on a conjugated polypyrrole polymer containing epoxy active side groups (PPCE) modified indium tin oxide (ITO) electrode was developed for detection of interleukin 6 (IL 6), a prostate cancer biomarker. polypyrrole polymer 56-75 interleukin 6 Homo sapiens 192-205 31247373-6 2019 The influence of selected TLR7 agonists on cytokine production is also reported showing that N-cyclopropyl-2-(trifluoromethyl)quinazolin-4-amine (46) is able to induce increased levels of IL-6 and IL-8. n-cyclopropyl-2-(trifluoromethyl)quinazolin-4-amine 93-144 interleukin 6 Homo sapiens 188-192 32312453-1 2020 A novel impedimetric immunosensor based on a conjugated polypyrrole polymer containing epoxy active side groups (PPCE) modified indium tin oxide (ITO) electrode was developed for detection of interleukin 6 (IL 6), a prostate cancer biomarker. polypyrrole polymer 56-75 interleukin 6 Homo sapiens 207-211 31322196-5 2019 The expression levels of interleukin (IL)-6, IL-8 and monocyte chemoattractant protein-1 increased following treatment with S100A8 and S100A9, and the increase was significantly blocked by specific signaling pathway inhibitors, including toll-like receptor 4 inhibitor (TLR4i), rottlerin, PD98059, SB203580 and BAY-11-7085. rottlerin 278-287 interleukin 6 Homo sapiens 25-43 32702669-3 2020 The in vitro assays showed that miR-141-3p mimics inhibited expression of IL-6 and TNF-alpha and reduced PI positive rate of the LPS-treated Caco-2 cells. mir-141-3p 32-42 interleukin 6 Homo sapiens 74-78 32440504-7 2020 Furthermore, GEN inhibited IL-6-induced vascular endothelial cell migration and tube formation in vitro. Genistein 13-16 interleukin 6 Homo sapiens 27-31 31327593-5 2019 CSF IL-6 levels were associated with the infiltration rate of TAMs in GBMs, and IL-6 levels were increased in the GBM cells co-cultured with TAM-like macrophages. tams 62-66 interleukin 6 Homo sapiens 4-8 32440504-8 2020 Conclusion: GEN inhibits IL-6-induced VEGF expression and angiogenesis partially through the Janus kinase 2 (JAK2)/STAT3 pathway in RA, which has provided a novel insight into the antiangiogenic activity of GEN in RA. Genistein 12-15 interleukin 6 Homo sapiens 25-29 32538414-7 2020 The administration of PSomes loaded with OVA and MPLA induced the production of interleukin-6 and tumor necrosis factor-alpha cytokines by macrophage activation in vitro and elicited effective Ag-specific antibody responses in vivo. monophosphoryl lipid A 49-53 interleukin 6 Homo sapiens 80-93 30991230-12 2019 IL-6 correlated significantly with CS, age, renal function and CRP. Cesium 35-37 interleukin 6 Homo sapiens 0-4 31396715-3 2019 TES products stimulated macrophages to produce the innate proinflammatory IL-1beta, IL-6, and TNF-alpha cytokines regardless of the presence of glycans. TES 0-3 interleukin 6 Homo sapiens 84-88 31363829-7 2019 Among the entire patient population, SUA levels significantly increased 3 months after starting treatment with TNFis (279.5 [84.0] vs. 299.0 [102.0] mumol/l, p < 0.0001), while the levels of CRP, IL-6, IL-8, and MCP-1 significantly decreased. sua 37-40 interleukin 6 Homo sapiens 199-203 31721534-13 2020 Conclusion: Combined treatment with ATO and THAL can inhibit proliferation and invasion of AML cells by down-regulating ULK1 and BECLIN1 and up-regulating PTEN and IL6, and this effect was more marked than the effects of ATO and THAL alone. ato 36-39 interleukin 6 Homo sapiens 164-167 30767875-12 2019 Cerulenin repressed the expressions of IL-6, CCL20 and IL-8 in RASFs stimulated by LTF. Cerulenin 0-9 interleukin 6 Homo sapiens 39-43 31009103-5 2019 Eriodictyol significantly reduced RA-FLS secretion of tumor necrosis factor alpha, interleukin 6 (IL-6), IL-8, and IL-1beta. eriodictyol 0-11 interleukin 6 Homo sapiens 83-96 31009103-5 2019 Eriodictyol significantly reduced RA-FLS secretion of tumor necrosis factor alpha, interleukin 6 (IL-6), IL-8, and IL-1beta. eriodictyol 0-11 interleukin 6 Homo sapiens 98-102 31612309-13 2019 Statistically significant reduction in IL-6 concentration was observed in the glutamine group at the end of treatment (87.44 +- 7.1 vs. 63.42 +- 33.7 muM/L; p = 0.02). arginyl-glutamine 78-87 interleukin 6 Homo sapiens 39-43 31017309-6 2019 Ap and Bl exposure to 100 mug/mL sono ZnO NPs and Ap exposure to 50 mug/mL commercial ZnO NPs induced a significant (P < 0.05) release of interleukin-6. Zinc Oxide 86-89 interleukin 6 Homo sapiens 141-154 31721534-13 2020 Conclusion: Combined treatment with ATO and THAL can inhibit proliferation and invasion of AML cells by down-regulating ULK1 and BECLIN1 and up-regulating PTEN and IL6, and this effect was more marked than the effects of ATO and THAL alone. Thalidomide 44-48 interleukin 6 Homo sapiens 164-167 31773201-13 2020 In addition, ISB with DEX showed lower mean plasma IL-6 and IL-8 levels than ISB alone within 48 h postoperatively, with delayed rebound pain. Dexmedetomidine 22-25 interleukin 6 Homo sapiens 51-55 31241043-5 2019 Our study showed that especially high concentrations of diosmin decreased NO, PGE2, IL-6, IL-12, TNF-alpha production and mRNA levels of these mediators (p < 0.05). Diosmin 56-63 interleukin 6 Homo sapiens 84-88 31480533-9 2019 The produced EGCG microparticles reduced the expression of inflammatory (IL-6, IL-8, COX-2) and catabolic (MMP1, MMP3, MMP13) mediators in pro-inflammatory 3D cell cultures. epigallocatechin gallate 13-17 interleukin 6 Homo sapiens 73-77 32564053-7 2020 RESULTS Compared with the healthy controls, the serum expression of IL-18, IL-33, IFN-gamma, IL-5, IL-6, IL-8, and IL-13 were significantly higher in the MPP and NMPP groups. nmpp 162-166 interleukin 6 Homo sapiens 99-103 31462286-7 2019 In these responder patients rifaximin normalized all alterations in the immune system measured while in non-responders it normalizes only IL-6, CCL20, and differentiation of T lymphocytes to Th22. Rifaximin 28-37 interleukin 6 Homo sapiens 138-142 31030090-3 2019 In this study, our findings showed that ACD treatment could reduce the high lethality rate; decrease the serum levels of alanine transaminase (ALT), aspartate aminotransferase (AST), monocyte chemoattractant protein (MCP)-1, interleukin-1beta (IL-1beta), IL-6 and tumor necrosis factor-alpha (TNF-alpha), and ameliorate the pathological hepatic damage of ALF. atractylodin 40-43 interleukin 6 Homo sapiens 255-259 31028753-6 2019 With respect to cytokine inductions, APCs treated with either Sal-HA or Sal-M2e induced significantly (p < .05) higher mRNA transcription levels of proinflammatory (IL-1beta, IL-6, IL-12 and IL-23), Th1 (IFN-gamma), Th17 (IL-17 and IL-21) and Th2 (IL-10 and TGF-beta) cytokines in T cells compared to Sal-NA or Salmonella alone treated APCs. sal-m2e 72-79 interleukin 6 Homo sapiens 178-182 32564053-9 2020 Significant differences were also observed between the MPP group and NMPP group patients in levels of IL-18, IL-5, and IL-6, and further ROC analysis showed that the area under the curve (AUC) of IL-18 and IL-5 were 0.813 (95% CI: 0.710-0.917; P<0.01) and 0.844 (95% CI: 0.756-0.933; P<0.01), respectively. nmpp 69-73 interleukin 6 Homo sapiens 119-123 31534459-9 2019 Global gene expression profiling of LY411575-treated cells revealed changes in multiple signaling pathways, including focal adhesion, insulin, TGFbeta, IL6, and Notch signaling, and decreased the expression of genes associated with functional categories of tissue development. N2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamide 36-44 interleukin 6 Homo sapiens 152-155 32570911-6 2020 RESULTS: Our data showed that ZnO was able to reduce the inflammatory response of DECs, in terms of vascular cell adhesion molecule-1 (VCAM-1), interleukin (IL)-8, IL-6, tumor necrosis factor-alpha (TNF-alpha) and monocyte chemoattractant protein-1 (MCP-1) expression induced by TNF-alpha stimulation. Zinc Oxide 30-33 interleukin 6 Homo sapiens 164-168 31054440-8 2019 ELISA assay and western blot indicated that HO-1, JNK, IL6, TNF, NF-kappaB, and FGF14 were significantly increased after exposure to PM2.5 while Casp3 and FGFR were decreased, which were consistent with the multi-omics. [4-(3-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]-(5-PHENETHYL- PYRIDIN-3-YL)-METHANONE 133-136 interleukin 6 Homo sapiens 55-58 31537245-12 2019 Results Palmitate increased the triglycerides level, induced the oxidative stress in both the cells and the mitochondria, decreased the gene expression and protein levels of SIRT1, PGC1alpha, SOD2 and CAT, increased the levels of TNF-alpha and IL-6, decreased the mitochondrial membrane potential, and impaired the mitochondrial function. Palmitates 8-17 interleukin 6 Homo sapiens 244-248 32536965-14 2020 Second, the molecular docking results showed that there was a certain affinity between the core compounds (kaempferol, quercetin, 7-Methoxy-2-methyl isoflavone, naringenin, formononetin) and core target genes (IL6, IL1B, CCL2). 7-methoxy-2-methyl isoflavone 130-159 interleukin 6 Homo sapiens 210-213 31117377-9 2019 However, the absence of polymer coating on the sphere GNPs and the rod shape caused a decrease in IL-6 cytokine production by activated B lymphocytes, suggesting a functional impairment. Polymers 24-31 interleukin 6 Homo sapiens 98-102 30884982-8 2019 Travatan and Lumigan 0.03% increased concentrations of Interleukin (IL)-6 and IL-8 in culture media. Bimatoprost 13-20 interleukin 6 Homo sapiens 55-73 31609478-8 2020 Gene expression analysis in PDAC tumors (n = 63) showed a positive correlation between the expression of NOS2 and the tryptophan/kynurenine pathway genes, including indoleamine-2,3-dioxygenase 1 (IDO1) and several aryl hydrocarbon receptor (AHR)-target genes including NFE2L2 (NRF2), SERPINB2, IL1b, IL6 and IL8, which are implicated in pancreatic cancer. Kynurenine 129-139 interleukin 6 Homo sapiens 300-303 31222133-5 2019 In complementary experiments, treatment with neutralizing antibodies against these proinflammatory cytokines or their receptors to inhibit of IL-6- or TNFalpha-mediated signaling repressed palmitate-induced phase shifts of the fibroblast clock. Palmitates 189-198 interleukin 6 Homo sapiens 142-147 31078926-5 2019 The Teneligliptin recovered LPS-induced a reduction of cellular glutathione and produced cytokine including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6). 3-(4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-ylcarbonyl)thiazolidine 4-17 interleukin 6 Homo sapiens 183-196 32343308-6 2020 The simultaneous administration of DEX and sufentanil significantly reduced plasma IL-6 and TNF-alpha concentrations and increased IL-10 level (P < 0.0001, P = 0.0003, and P = 0.0345, respectively), accompanied by better postoperative delirium categories and health statuses of patients (P = 0.024 and P < 0.05, respectively). Dexmedetomidine 35-38 interleukin 6 Homo sapiens 83-87 31078926-5 2019 The Teneligliptin recovered LPS-induced a reduction of cellular glutathione and produced cytokine including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6). 3-(4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-ylcarbonyl)thiazolidine 4-17 interleukin 6 Homo sapiens 198-202 30891836-5 2019 The results proved that isofraxidin attenuated the IL-1beta-induced significant increases in inflammatory mediators and cytokines including nitric oxide (NO), inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-alpha), and IL-6. isofraxidin 24-35 interleukin 6 Homo sapiens 285-289 30879690-4 2019 Secretion of interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha (254.7 pg/mL, 2.5 ng/mL, and 42.9 pg/mL, respectively) was significantly induced by NFG. 2,4-Dinitrophenyl 2-Deoxy-2-Fluoro-Beta-D-Glucopyranoside 163-166 interleukin 6 Homo sapiens 13-26 30888047-6 2019 In human cells, while Cr induced a release of ATP, IL-6, and IL-8 from BEAS-2B cells, whole blood cells, such as eosinophils, and CD4+ T cells, P2 x 7 receptor inhibitor (A740003) reduced such effects, as denoted by reduced levels of ATP, IL-6, and IL-8. Creatine 22-24 interleukin 6 Homo sapiens 51-55 30888047-6 2019 In human cells, while Cr induced a release of ATP, IL-6, and IL-8 from BEAS-2B cells, whole blood cells, such as eosinophils, and CD4+ T cells, P2 x 7 receptor inhibitor (A740003) reduced such effects, as denoted by reduced levels of ATP, IL-6, and IL-8. Creatine 22-24 interleukin 6 Homo sapiens 239-243 32481266-9 2020 Meanwhile, the area under the curve (AUC) of IL-8 in EBC was significantly lower at T2 and the AUC of IL-6 in EBC was significantly higher at T4 than in serum (P < .05). NSC638702 110-113 interleukin 6 Homo sapiens 102-106 30988370-5 2019 Herein the systematic removal of carbons from either the hydroxy fatty acid or fatty acid regions of the most studied FAHFA, palmitic acid ester of 9-hydroxystearic acid (9-PAHSA), was achieved and these synthetic, abridged analogs were tested for their ability to attenuate IL-6 production. 9-PAHSA 171-178 interleukin 6 Homo sapiens 275-279 31356535-12 2019 The IL-6 and IL-8 concentrations in the DEX group were dramatically increased at 6 hours after CPB (P < 0.05). Dexmedetomidine 40-43 interleukin 6 Homo sapiens 4-8 31085401-3 2019 Herein, a highly sensitive and selective aptasensor for quantitative detection of interleukin-6 was developed by using a glassy carbon electrode modified with p-aminobenzoic acid, p-aminothiophenol and gold nanoparticles. 4-Aminobenzoic Acid 159-178 interleukin 6 Homo sapiens 82-95 31981623-7 2020 TNFalpha triggered interleukin (IL) 6 and 8 release into the medium, which was inhibited by EA in a dose-dependent manner (IC50 = 17.3 muM for IL-6). Ellagic Acid 92-94 interleukin 6 Homo sapiens 19-37 31005040-5 2019 The results showed that oridonin significantly inhibited inflammatory mediators PGE2, NO, IL-6, and IL-8 production. oridonin 24-32 interleukin 6 Homo sapiens 90-94 31045788-10 2019 Furthermore, perioperative dexmedetomidine treatment significantly decreased IL-6 (SMD = -1.31, 95% CI -1.87-0.75, P < .001) and TNF-alpha (SMD = -2.14, 95% CI -3.14-1.14, P < .001) compared to saline/comparators treatment. Dexmedetomidine 27-42 interleukin 6 Homo sapiens 77-81 31981623-7 2020 TNFalpha triggered interleukin (IL) 6 and 8 release into the medium, which was inhibited by EA in a dose-dependent manner (IC50 = 17.3 muM for IL-6). Ellagic Acid 92-94 interleukin 6 Homo sapiens 143-147 31005040-8 2019 Further studies showed that PPARgamma inhibitor GW9662 could reverse the inhibition of oridonin on PGE2, NO, IL-6, and IL-8 production. oridonin 87-95 interleukin 6 Homo sapiens 109-113 32477139-12 2020 Conclusion: Dexmedetomidine reduced the incidence of POD in elderly patients on the first day after hip fracture surgery, and reduced IL-6 and TNF-alpha levels over the first 3 days after surgery. Dexmedetomidine 12-27 interleukin 6 Homo sapiens 134-138 30865473-6 2019 Moreover, palmitate induced gene expression (monocyte chemoattractant protein 1, matrix metalloproteinase-2, IL-1beta, IL-6, IL-8, and TNF-alpha) and intracellular protein content (plasminogen activator inhibitor-1 and urokinase plasminogen activator) of inflammatory mediators. Palmitates 10-19 interleukin 6 Homo sapiens 119-123 30789669-9 2019 Additionally, LH supplementation significantly downregulated the mRNA expression of nuclear factor (NF)-kappaB, cyclooxygenase-2 (COX-2), and proinflammatory cytokines (TNF-alpha, IL-1beta, and IL-6) and upregulated the mRNA expression of zonula occludens-1 (ZO-1) and Occludin in the jejunal mucosa induced by LPS (P < 0.05). Luteinizing Hormone 14-16 interleukin 6 Homo sapiens 194-198 32312819-7 2020 Furthermore, glutamine deprivation, as well as the antimetabolic drugs 2-deoxyglucose and metformin, also promoted the release of IL-6 and IL-8. Glutamine 13-22 interleukin 6 Homo sapiens 130-134 30690290-0 2019 Palmitate-induced IL6 expression ameliorated by chicoric acid through AMPK and SIRT1-mediated pathway in the PBMCs of newly diagnosed type 2 diabetes patients and healthy subjects. Palmitates 0-9 interleukin 6 Homo sapiens 18-21 31186772-0 2019 Effect of dexmedetomidine anesthesia on perioperative levels of TNF-alpha and IL-6 in patients with ovarian cancer. Dexmedetomidine 10-25 interleukin 6 Homo sapiens 78-82 31186772-1 2019 Effect of continuous use of dexmedetomidine during general anesthesia on perioperative levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in patients undergoing radical resection of ovarian cancer was investigated. Dexmedetomidine 28-43 interleukin 6 Homo sapiens 141-154 32051095-0 2020 Atorvastatin inhibits IL-17A, TNF, IL-6, and IL-10 in PBMC cultures from patients with severe rheumatoid arthritis. atorvastatin 0-12 interleukin 6 Homo sapiens 35-39 31186772-8 2019 Serum TNF-alpha and IL-6 levels were significantly lower in the dexmedetomidine group than that in the midazolam group. Dexmedetomidine 64-79 interleukin 6 Homo sapiens 20-24 31186772-9 2019 If dexmedetomidine were continuously used during general anesthesia, the perioperative serum levels of TNF-alpha and IL-6 could be effectively reduced in patients undergoing radical resection of ovarian cancer, and the perioperative stress response was suppressed. Dexmedetomidine 3-18 interleukin 6 Homo sapiens 117-121 31008484-11 2019 PI3K inhibitor LY294002 and P38 inhibitor SB202190 blocked 17-phenyl-trinor-PGE2-induced IL-1beta and IL-6 output, respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 15-23 interleukin 6 Homo sapiens 102-106 30366934-10 2019 Among the subgroup with inflammatory biomarker measurements, higher interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1) and B-cell activating factor levels were independently associated with longer QTc and their inclusion partially attenuated the HIV effect. qtc 211-214 interleukin 6 Homo sapiens 68-81 30366934-10 2019 Among the subgroup with inflammatory biomarker measurements, higher interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1) and B-cell activating factor levels were independently associated with longer QTc and their inclusion partially attenuated the HIV effect. qtc 211-214 interleukin 6 Homo sapiens 83-87 32051095-10 2020 RESULTS: Atorvastatin showed no toxicity at the tested doses in RA PBMC cultures, and at 10muM, it showed the most significant results, reducing IL-17A (p = 0.002), TNF (p = 0.002), and IL-6 (p = 0.008) supernatant levels. atorvastatin 9-21 interleukin 6 Homo sapiens 186-190 30880909-9 2019 Conclusion: Administration of seawater is more effective than treatment with carmellose artificial tears in reducing symptoms and pro-inflammatory molecules (IL-1 beta and IL-6) in tears of patients with DES. Carboxymethylcellulose Sodium 77-87 interleukin 6 Homo sapiens 172-176 32598720-9 2020 68% of patients with exacerbation of CP, receiving in addition to the standard regimen rifaximin, achieved clinical improvement, normalization of intestinal biocenosis, reduced concentrations of cytokines in tissues, reducing signs of chronic inflammation in the colon mucosa with reducing concentrations of IL-2, IL-6, IL-8 in colon mucosa (p0.05). Rifaximin 87-96 interleukin 6 Homo sapiens 314-318 30508574-4 2019 N3 PUFAs (DHA 8.7 muM/EPA14.21 muM) or clozapine (3 muM) significantly reduced poly I:C-induced increase in iNOS, NFkB (p50/p65), IL-6 and nitrite when compared to non-treated cells. Fatty Acids, Unsaturated 3-8 interleukin 6 Homo sapiens 130-134 30502626-0 2019 1,3,4-oxadiazole/chalcone hybrids: Design, synthesis, and inhibition of leukemia cell growth and EGFR, Src, IL-6 and STAT3 activities. Chalcone 17-25 interleukin 6 Homo sapiens 108-112 30502626-1 2019 A new series of 1,3,4-oxadiazole/chalcone hybrids was designed, synthesized, identified with different spectroscopic techniques and biologically evaluated as inhibitors of EGFR, Src, and IL-6. Chalcone 33-41 interleukin 6 Homo sapiens 187-191 31105821-6 2019 Notably, our findings indicate that sitagliptin possesses an anti-inflammatory effect against H/R-induced expression of IL-6, IL-8, and TNF-alpha as well as secretion of HMGB1. Sitagliptin Phosphate 36-47 interleukin 6 Homo sapiens 120-124 30724633-9 2019 The synergistic effect of nano-SiO2 and IL-1beta was observed on the new production of IL-1beta and IL-6 in A549 cells. Silicon Dioxide 31-35 interleukin 6 Homo sapiens 100-104 30724633-10 2019 The Western blot results showed that nano-SiO2 can increase the expression of IL-1beta and IL-6 by promoting the phosphorylation of ERK1/2 and elevating the phosphorylation of I-kappaB by IL-1beta. Silicon Dioxide 42-46 interleukin 6 Homo sapiens 91-95 30724633-11 2019 IL-1beta and IL-6 were induced by nano-SiO2, and the IL-1beta treatment with 20 muM of I-kappaBalpha phosphorylation inhibitor (PD98059) and 20 muM of ERK1/2 inhibitor (BAY11-7082) for 1 h was significantly lower than that of the control group in A549 cells. Silicon Dioxide 39-43 interleukin 6 Homo sapiens 13-17 30295316-16 2019 Vitamin D inhibited IL-6 and IL-8 production stimulated by G-HSA or HSA + IL-1beta or IL-1beta + IL-17. g-hsa 59-64 interleukin 6 Homo sapiens 20-24 32293469-7 2020 Meta-analysis revealed that higher consumption of resistant starch caused a significant reduction in the interleukin 6 (weighted mean difference = - 1.11 pg/mL; 95% CI: - 1.72, - 0.5 pg/mL; P = < 0.001) and tumor necrosis factor alpha (weighted mean difference = - 2.19 pg/mL; 95% CI: - 3.49, - 0.9 pg/mL; P = 0.001) levels. Starch 60-66 interleukin 6 Homo sapiens 105-118 30207136-10 2019 At 90 min, IL-6 was significantly lower in the dexmedetomidine group than in the control group (P=0.049). Dexmedetomidine 47-62 interleukin 6 Homo sapiens 11-15 30639962-12 2019 In addition, pretreatment with JNK, ERK, P38, and NF-kB inhibitors could correspondingly attenuate palmitate-induced expression of VEGF, IL-6, and MCP-1. Palmitates 99-108 interleukin 6 Homo sapiens 137-141 32163856-7 2020 In human rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs), DEX (250 nM and 500 nM) was found to inhibit the expression of IL-1beta, IL-6, MMP-3, MMP-9, and P-P65 following stimulation with TNF-alpha. Dexmedetomidine 70-73 interleukin 6 Homo sapiens 143-147 30638709-6 2019 Treatment ex vivo with TPC decreased the production of IL-1beta, IL-2, IL-5, IL-6, IL-9, IL-12(p70), IL-13, IL-17A, IL-18, IL-21, IL-22, IL-23, IFNgamma, TNFalpha, GM-CSF by CD3/CD28 activated PBMCs whereas it negligibly affected cell viability. tpc 23-26 interleukin 6 Homo sapiens 77-81 30638709-8 2019 In inflamed TABs, treatment with TPC down-regulated the production of IL-1beta, IL-6, IL-13, IL-17A and CD68 gene expression. tpc 33-36 interleukin 6 Homo sapiens 80-84 30941358-16 2019 In 7 patients that completed the treatment period, there was an association between elevated serum levels of IL-6, IL-1beta, TNF-alpha, CRP, and LPL and also the reduced serum levels of albumin, prealbumin, Zn, vitamin D, and GPS, respectively. (9R,10R)-9-(S-GLUTATHIONYL)-10-HYDROXY-9,10-DIHYDROPHENANTHRENE 226-229 interleukin 6 Homo sapiens 109-113 31794890-5 2020 We observed that SchA accelerated cell proliferation, prohibited apoptosis, and restrained pro-inflammatory cytokines (monocyte chemoattractant protein-1 [MCP-1], interleukin-6 [IL-6], and tumor necrosis factor alpha [TNF-alpha]) and reactive oxygen species (ROS) level in HG-stimulated cells. schizandrin A 17-21 interleukin 6 Homo sapiens 163-176 30595336-8 2019 Besides, the production of TNF-alpha, IL-1beta, IL-6, fibronectin (FN) and collagen IV (Col IV) was also inhibited by daphnetin in HG-stimulated MCs. daphnetin 118-127 interleukin 6 Homo sapiens 48-52 30604480-4 2019 Compared with controls, SA-pretreated human chondrocytes showed lower levels of interleukin (IL)-1beta-induced IL-6, prostaglandin E2 (PGE2), nitric oxide (NO) and tumour necrosis factor-alpha (TNF-alpha) in vitro. sinapinic acid 24-26 interleukin 6 Homo sapiens 111-115 31794890-5 2020 We observed that SchA accelerated cell proliferation, prohibited apoptosis, and restrained pro-inflammatory cytokines (monocyte chemoattractant protein-1 [MCP-1], interleukin-6 [IL-6], and tumor necrosis factor alpha [TNF-alpha]) and reactive oxygen species (ROS) level in HG-stimulated cells. schizandrin A 17-21 interleukin 6 Homo sapiens 178-182 30863067-14 2019 LY294002, a PI3K (phosphatidylinositol 3-kinase)/AKT inhibitor, also suppressed the expression of TNF-alpha, IL-6 and TGF-beta, and simultaneously, reduced the production of alpha-SMA and collagen I in HKFs. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 interleukin 6 Homo sapiens 109-113 31818575-8 2020 Aromatics content contributed to more significant PAH-mediated IL-6 downregulation, whereas ethanol content was associated with decreased downregulation of IL-6. p-Aminohippuric Acid 50-53 interleukin 6 Homo sapiens 63-67 30548778-11 2019 Pearson correlation analysis showed IL-1beta was positively correlated with CBL (P = .0079), whereas IL-6 showed positive correlation with both BOP (P = .0019) and CBL (P = .015) among obese patients. Vitamin B 12 164-167 interleukin 6 Homo sapiens 101-105 30621055-4 2019 We found that OMT can inhibit the constitutive activation of STAT5 by suppressing the activation of JAK1/2 and c-Src, nuclear localization, as well as STAT5 binding to DNA in A549 cells and abrogated IL-6-induced STAT5 phosphorylation in H1299 cells. oxymatrine 14-17 interleukin 6 Homo sapiens 200-204 32081843-11 2020 Finally, we chose the top 5 common targets, CCND1, EGFR, IL6, MAPK8, and VEGFA, for molecular docking with the 11 active ingredients of CS. Cesium 136-138 interleukin 6 Homo sapiens 57-60 31508724-8 2019 An increase in the levels of IL-2, IL-4, IL-6, IL-10 and TNF-alpha was observed in the ATS and CS groups. Cesium 95-97 interleukin 6 Homo sapiens 41-45 30635033-13 2019 Based on the hypothesis that antagonizing the effects of IL-6 improves the outcome of DSA-positive late ABMR by counteracting DSA-triggered inflammation and B cell/plasma cell-driven alloimmunity, we suggest that our trial has the potential to provide proof of concept of a novel treatment of this type of rejection. dsa 86-89 interleukin 6 Homo sapiens 57-61 30635033-13 2019 Based on the hypothesis that antagonizing the effects of IL-6 improves the outcome of DSA-positive late ABMR by counteracting DSA-triggered inflammation and B cell/plasma cell-driven alloimmunity, we suggest that our trial has the potential to provide proof of concept of a novel treatment of this type of rejection. dsa 126-129 interleukin 6 Homo sapiens 57-61 30273577-8 2019 The involvement of sphingolipids in the cooperative stimulation by palmitate and LPS on cytokine expression was indicated by the findings that the inhibitor of CER de novo synthesis or SM hydrolysis attenuated the stimulation of IL-6 expression by palmitate and LPS. Palmitates 67-76 interleukin 6 Homo sapiens 229-233 32076394-0 2020 Dexmedetomidine May Reduce IL-6 Level and the Risk of Postoperative Cognitive Dysfunction in Patients After Surgery: A Meta-Analysis. Dexmedetomidine 0-15 interleukin 6 Homo sapiens 27-31 30273577-8 2019 The involvement of sphingolipids in the cooperative stimulation by palmitate and LPS on cytokine expression was indicated by the findings that the inhibitor of CER de novo synthesis or SM hydrolysis attenuated the stimulation of IL-6 expression by palmitate and LPS. Palmitates 248-257 interleukin 6 Homo sapiens 229-233 30273577-9 2019 In addition, our study showed that fatty acid receptors GPR40 and CD36 were involved in the IL-6 upregulation by palmitate and LPS. Palmitates 113-122 interleukin 6 Homo sapiens 92-96 30597965-0 2018 IL-6 in Osteoarthritis: Effects of Pine Stilbenoids. stilbenoids 40-51 interleukin 6 Homo sapiens 0-4 31345146-10 2019 RESULTS: Compared with control group, the folic acid plus vitamin B 12 group had significantly greater improvements in serum folate, homocysteine, vitamin B 12 and IL-6, TNF-alpha, MCP-1. Vitamin B 12 58-70 interleukin 6 Homo sapiens 164-168 31509851-11 2019 Models that were treated with the BFZ-containing ointment after histamine application showed an upregulation of members of the cytochrome P450 family (CAP1A1, CYP1B1, and CYP24A1) and a downregulation of immune response-associated genes (CXCL6, CXCL12, CCL8, IL6, and IL32). bifonazole 34-37 interleukin 6 Homo sapiens 259-262 30597965-7 2018 Natural stilbenoids monomethyl pinosylvin and pinosylvin increased aggrecan expression and suppressed IL-6 production in OA chondrocytes. stilbenoids 8-19 interleukin 6 Homo sapiens 102-106 31735734-4 2020 The results revealed that BAC suppressed gene and protein expression of IL-6 and IL-8 induced by IL-1beta. 4-deoxyneosamine C 26-29 interleukin 6 Homo sapiens 72-76 30571738-8 2018 Finally, anti-Sm mAb still up-regulated the IL-6 production of monocytes in the presence of anti-RNP mAb under the influence of N-acetyl cysteine or pyrrolidine dithiocarbamate that totally abrogated the IL-6 production provoked by anti-Sm mAb alone in the absence of anti-RNP mAb. pyrrolidine dithiocarbamic acid 149-176 interleukin 6 Homo sapiens 44-48 30571738-8 2018 Finally, anti-Sm mAb still up-regulated the IL-6 production of monocytes in the presence of anti-RNP mAb under the influence of N-acetyl cysteine or pyrrolidine dithiocarbamate that totally abrogated the IL-6 production provoked by anti-Sm mAb alone in the absence of anti-RNP mAb. pyrrolidine dithiocarbamic acid 149-176 interleukin 6 Homo sapiens 204-208 31863784-6 2020 Blocking of IL-6 secreted from IL-33-matDCs suppressed the conversion of Tregs to Th17 cells, indicating the greater propensity to convert stable Tregs to Th17 cells is due to IL-6 signaling. tregs 73-78 interleukin 6 Homo sapiens 12-16 30713180-1 2018 AIM: Evaluation of the effect of glucosamine-chondroitin combination, tramadol, and sodium hyaluronic acid in temporomandibular joint (TMJ) disorders and its impact on the expression of various cytokines such as IL-6, IL-1beta, TNF-alpha, and PGE2. sodium hyaluronic acid 84-106 interleukin 6 Homo sapiens 212-216 30265541-8 2018 As a result, a mutation of IKKbetaC179A rescued the therapeutic effect of UA on Ti-particle-induced inflammation, including morphological transforms, upregulation of iNOS and COX-2, increased secretions of TNF-alpha, IL-1beta, and IL-6, and decreased secretion of IL-10. ursolic acid 74-76 interleukin 6 Homo sapiens 231-235 30051214-9 2018 The serum IL-6 and CRP levels were inversely correlated with the plasma concentration ratios of N-desmethyltramadol to tramadol and of N,O-didesmethyltramadol to O-desmethyltramadol. Tramadol 107-115 interleukin 6 Homo sapiens 10-14 31863784-6 2020 Blocking of IL-6 secreted from IL-33-matDCs suppressed the conversion of Tregs to Th17 cells, indicating the greater propensity to convert stable Tregs to Th17 cells is due to IL-6 signaling. tregs 146-151 interleukin 6 Homo sapiens 12-16 30051214-10 2018 The serum IL-6 level was associated with the treatment duration of oral tramadol. Tramadol 72-80 interleukin 6 Homo sapiens 10-14 30173151-2 2018 We compared QTc between patients with RA and demographically matched controls and studied the change in QTc after treatment with the interleukin 6 inhibitor tocilizumab (TCZ). qtc 104-107 interleukin 6 Homo sapiens 133-146 32005799-5 2020 Interruption of IL-6/JAK/STAT3 pathway by a JAK inhibitor AZD1480 reverses the pro-metastatic effect of sevoflurane and the associated increase of both activated STAT3 and infiltrated CD11b+ cells in 4T1 model. AZD 1480 58-65 interleukin 6 Homo sapiens 16-20 30333255-8 2018 The effects of GCN5 overexpression on cell proliferation and invasion were suppressed by LY294002, In conclusion, these data demonstrated the negative effect of up-regulated GCN5 in IL-6-induced metastasis and EMT in PCa cells through PI3K/PTEN/Akt signaling pathway down-regulating Egr-1 expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 89-97 interleukin 6 Homo sapiens 182-186 30051214-12 2018 The serum IL-6 level was associated with N-demethylation activity and tramadol tolerability. Tramadol 70-78 interleukin 6 Homo sapiens 10-14 31928157-8 2020 Medin induced EC immune activation (increased interleukin-8, interleukin-6, intercellular adhesion molecule-1, and plasminogen activator inhibitor-1) and reduced EC viability, which were reversed by monosialoganglioside-containing nanoliposomes. sialogangliosides 199-219 interleukin 6 Homo sapiens 61-74 30348950-9 2018 Azithromycin showed the same effect in imitated SLE macrophages, with distinct Akt phosphorylation at 30 min and 12 h. After inhibiting Akt phosphorylation by LY294002, the down-regulation of CD80, IL-1beta, IL-6, and TNF-alpha caused by azithromycin raised again, meanwhile, the up-regulation of CD206, Arg-1, Fizz-1, and IL-10 due to azithromycin was abolished. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 159-167 interleukin 6 Homo sapiens 208-212 30515094-19 2018 Ultimately paeonol decreased the expression of IL-1beta, IL-6, ICAM-1, VCAM-1 in HUVECs and alleviated adhesion of THP-1 cells to HUVECs. paeonol 11-18 interleukin 6 Homo sapiens 57-61 32038106-10 2020 Results: We demonstrated that mifepristone reduced the secretion of IL-6 and TNF-alpha from endometrial epithelial and stromal cells, restricted the infiltration and degranulation of mast cells in eutopic and ectopic endometrium and decreased the density of nerve fibers by inhibiting the migration capacity of nerve cells in adenomyosis. Mifepristone 30-42 interleukin 6 Homo sapiens 68-72 30077906-7 2018 MCN, MCN-PVP and MCN-PEG promoted the differentiation and maturation of the DCs, while the levels of secreted TNF-alpha and IL-6 were significantly suppressed by MCN-PVP and MCN-PEG. mcn-peg 174-181 interleukin 6 Homo sapiens 124-128 29894789-3 2018 The combined supplementation with allopurinol and l-arginine increased catalase, SOD, GSH, and Gpx, while it decreased lipid peroxidation, IL-6, IL-1beta, and TNF-alpha. Allopurinol 34-45 interleukin 6 Homo sapiens 139-143 29894789-4 2018 While TNF-alpha, IL-6, IL-1beta, and NF-kappaB mRNA and protein expression were higher in control HOb-OA cells, the combined supplementation with allopurinol and l-arginine substantially reduced their expression in HOb-OA cells by >40%. Allopurinol 146-157 interleukin 6 Homo sapiens 17-21 31931847-0 2020 Correction to: DNMT3b/OCT4 expression confers sorafenib resistance and poor prognosis of hepatocellular carcinoma through IL-6/STAT3 regulation. sorafenib 46-55 interleukin 6 Homo sapiens 122-126 29429001-6 2018 In the in vitro testing EOCl inhibited the production of pro-inflammatory cytokines (TNF-alpha, IL-6, IL-1beta) in lipopolysaccharide (LPS) and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in the human keratinocyte cell line (HaCaT). eocl 24-28 interleukin 6 Homo sapiens 96-100 29907500-11 2018 The expression of interleukin-6 in lung tissue and plasma was significantly reduced in the D+R group compared with the Control group (p = 0.036). d+r 91-94 interleukin 6 Homo sapiens 18-31 30114464-6 2018 Of note, the mRNA levels of IL-6 and IL-8 were approximately two-fold higher when cells were stimulated with 3 x 107 CFU/ml of r-SP for 3 h, while the protein levels of IL-6 and IL-8 were approximately five-fold higher after stimulation with 3 x 107 CFU/ml of r-SP for 24 h. Furthermore, r-SP exhibited potent activation of Toll-like receptor 2 compared with h-SP or f-SP. h-sp 359-363 interleukin 6 Homo sapiens 28-32 30347644-4 2018 The PUFAs and fish oil formulation completely mitigated or diminished the DEP-induced release of IL-6, IL-8, and ET-1 by 14-78%. Fatty Acids, Unsaturated 4-9 interleukin 6 Homo sapiens 97-101 32011832-12 2020 Further testing showed that isoflurane could significantly decrease the cell viability and increase the apoptosis of PC-12, the expression of inflammatory cytokines (TNF-alpha and IL-6) and ROS (p < 0.05). Isoflurane 28-38 interleukin 6 Homo sapiens 180-184 29847844-3 2018 While ellagic acid"s antioxidant properties are doubtless responsible for many of its pharmacological activities, other mechanisms have also been implicated in its various effects, including its ability to reduce the lipidemic profile and lipid metabolism, alter pro-inflammatory mediators (tumor necrosis factor-alpha, interleukin-1beta, interleukin-6), and decrease the activity of nuclear factor-kappaB while increasing nuclear factor erythroid 2-related factor 2 expression. Ellagic Acid 6-18 interleukin 6 Homo sapiens 339-352 30324111-14 2018 Regarding inflammatory cytokines, genistein and L-carnitine had less effect on TNF-alpha than on IL-6. Genistein 34-43 interleukin 6 Homo sapiens 97-101 31969092-10 2020 Lupeol alone or in combination with approved drugs inhibits inflammation in different cancer cells through modulation of expression of IL-6, TNF-alpha, and IFN-gamma. lupeol 0-6 interleukin 6 Homo sapiens 135-139 30271438-0 2018 D-Mannose Enhanced Immunomodulation of Periodontal Ligament Stem Cells via Inhibiting IL-6 Secretion. Mannose 0-9 interleukin 6 Homo sapiens 86-90 30271438-6 2018 We found that less IL-6 could be detected in D-mannose-pretreated hPDLSCs. Mannose 45-54 interleukin 6 Homo sapiens 19-23 30271438-7 2018 In the D-mannose pretreatment group, induced Treg cell number would decrease if increased IL-6 levels could be detected. Mannose 9-16 interleukin 6 Homo sapiens 90-94 29963999-0 2018 Dibutyryl cAMP- or Interleukin-6-induced astrocytic differentiation enhances mannose binding lectin (MBL)-associated serine protease (MASP)-1/3 expression in C6 glioma cells. Mannose 77-84 interleukin 6 Homo sapiens 19-32 31748348-4 2020 KDM6-specific chemical inhibition (GSK J4) in BMDC led to decreased production of chemokines and cytokines associated with the inflammatory response during RSV infection (i.e., CCL-2, CCL-3, CCL-5, IL-6) as well as decreased MHC class II and costimulatory marker (CD80/86) expression. kdm6 0-4 interleukin 6 Homo sapiens 198-202 29913408-9 2018 Tripterine alleviated LPS-induced reduction of cell viability, increase of apoptosis and the release of IL-6 and TNF-alpha in HaCaT cells. celastrol 0-10 interleukin 6 Homo sapiens 104-108 30175254-9 2018 Dietary L-theanine mitigated the elevated serum alpha1-AGP level on d 25, serum IL-6 concentration on d 24 and 26, and the decreased jejunal mucosal sIgA content on d 28 of the LPS-challenged birds. theanine 8-18 interleukin 6 Homo sapiens 80-84 31781916-2 2020 In this study, we hypothesized that IL-6 mediates its effects via SIRT1 as a protein deacetylase and activator of phosphatidylinositol-3 kinase pathways. Phosphatidylinositols 114-134 interleukin 6 Homo sapiens 36-40 29885023-8 2018 Moreover, with the treatment of IL-6 neutralizing antibody or src inhibitor, dasatinib, icotinib-induced phosphorylation of STAT3 was reduced, as well as the sensitivity of PC9 to icotinib was also partially increased. Dasatinib 77-86 interleukin 6 Homo sapiens 32-36 29744898-0 2018 Moderate correlation between systemic IL-6 responses and CRP with trough concentrations of voriconazole. Voriconazole 91-103 interleukin 6 Homo sapiens 38-42 29931171-9 2018 Stimulation of primary trophoblasts with palmitate led to increased mRNA expression and protein release of the cytokine IL6 and the chemokine IL8. Palmitates 41-50 interleukin 6 Homo sapiens 120-123 30122920-8 2018 Conclusion: Given that NIPAM-hemin induced IL-6 and IFN-gamma production in immune cells without any cytotoxic effects, NIPAM-hemin has potential therapeutic applications as a Th1-type adjuvant. nipam-hemin 23-34 interleukin 6 Homo sapiens 43-47 31740151-8 2020 Inflammation-fibrosis and calcification parameters showed positive regulation after paricalcitol treatment: interleukin-6 decreased significantly (p=.001) and also TNF-alpha did (p=.005), on the contrary, interleukin-10 and fetuin-A increased (p=.001 for both). paricalcitol 84-96 interleukin 6 Homo sapiens 108-121 30122920-8 2018 Conclusion: Given that NIPAM-hemin induced IL-6 and IFN-gamma production in immune cells without any cytotoxic effects, NIPAM-hemin has potential therapeutic applications as a Th1-type adjuvant. nipam-hemin 120-131 interleukin 6 Homo sapiens 43-47 30212928-0 2018 Effect of omega 3 fatty acids on C-reactive protein and interleukin-6 in patients with advanced nonsmall cell lung cancer. Fatty Acids, Omega-3 10-29 interleukin 6 Homo sapiens 56-69 32441198-3 2020 In addition, serum levels of TNF-alpha, IL-1beta, IL-6, IL-8, and tumor marker CEA were decreased significantly in omega-3, vitamin D, and co-supplementation of them, compared with baseline. Fatty Acids, Omega-3 115-122 interleukin 6 Homo sapiens 50-54 29902349-0 2018 Nab-paclitaxel interrupts cancer-stromal interaction through C-X-C motif chemokine 10-mediated interleukin-6 downregulation in vitro. nab 0-3 interleukin 6 Homo sapiens 95-108 29902349-11 2018 Moreover, nab-PTX increased CXCL10 expression of cancer cells which blocked CAF IL-6 expression and secretion. nab 10-13 interleukin 6 Homo sapiens 80-84 29902349-12 2018 Nab-PTX treatment could increase CXCL10 expression of cancer cells which blocks CAF cancer cell migration and invasion-promoting effect by inhibiting IL-6 expression. nab 0-3 interleukin 6 Homo sapiens 150-154 31888596-7 2019 The group comparison between filtered air and ZnO exposures showed statistically significant increases of neutrophils and interleukin-8 (IL-8), interleukin-6 (IL-6), matrix metalloproteinase (MMP-9) and tissue inhibitors of metalloproteinases (TIMP-1) in sputum starting at the lowest ZnO concentration of 0.5 mg/m3. Zinc Oxide 46-49 interleukin 6 Homo sapiens 144-157 29940201-4 2018 EGCG markedly decreased the levels of inflammatory and oxidative stress factors including nuclear factor kappaB (NF-kappaB), tumor necrosis factor-alpha, interleukin-6, reactive oxygen species, malondialdehyde and p53 protein, and markedly increased superoxide dismutases (SOD), glutathione peroxidase and SOD2 protein. epigallocatechin gallate 0-4 interleukin 6 Homo sapiens 154-167 30015902-5 2018 Pretreatment with spilanthol decreased TNF-alpha-induced COX-2 expression by western blotting and suppressed the expression of pro-inflammatory mediators, including interleukin (IL)-6, IL-8 and monocyte chemotactic protein 1 using ELISA. N-isobutyl-2E-decenamide 18-28 interleukin 6 Homo sapiens 165-183 30089708-10 2018 The 5% PEGLM hydrogels also promoted a significant increase in both vascular endothelial growth factor and interleukin-6 (IL-6) production from the myoblasts. peglm 7-12 interleukin 6 Homo sapiens 107-120 31888596-7 2019 The group comparison between filtered air and ZnO exposures showed statistically significant increases of neutrophils and interleukin-8 (IL-8), interleukin-6 (IL-6), matrix metalloproteinase (MMP-9) and tissue inhibitors of metalloproteinases (TIMP-1) in sputum starting at the lowest ZnO concentration of 0.5 mg/m3. Zinc Oxide 46-49 interleukin 6 Homo sapiens 159-163 30089708-10 2018 The 5% PEGLM hydrogels also promoted a significant increase in both vascular endothelial growth factor and interleukin-6 (IL-6) production from the myoblasts. peglm 7-12 interleukin 6 Homo sapiens 122-126 31007088-10 2019 In addition, mannose in the structure of MLCMNP improved IL-6, TNF-alpha and IFN-gamma (>16 fold) cytokines genes expression by macrophage/dendritic cells after exposure in 12 h. Immunization of experimental mice (subcutaneously, two times with 2-week intervals) with 5 microg of HBsAg loaded on MLCMNP nanoparticles increased specific total IgG and IgG2a/IgG1 ratio. Mannose 13-20 interleukin 6 Homo sapiens 57-61 30022657-6 2018 After that, the capture monoclonal antibody for IL-6, IL-1beta, and TNF-alpha was modified to the carboxylic acid terminated sensing interface. Carboxylic Acids 98-113 interleukin 6 Homo sapiens 48-52 29906743-3 2018 Costunolide treatment reduced LTA-induced neutrophil lung infiltration, cytokine and chemokine production (TNF-alpha, IL-6 and KC), and pulmonary edema. costunolide 0-11 interleukin 6 Homo sapiens 118-129 29377169-12 2018 eDMP markedly elevated initial production of IL-6 (P <= 0.002), but suppressed LPS-induced cytokine production in the later phase. edmp 0-4 interleukin 6 Homo sapiens 45-49 29846789-10 2018 However, IL-6, IL-12, IL-17 and IL-18 were significantly increased in pSS patients compared to controls. pss 70-73 interleukin 6 Homo sapiens 9-13 31146598-4 2019 Our findings demonstrate a novel ability of paeonol to inhibit numerous factors of OA, including expressions of IL-6, TNF-alpha, NOX2, PTGS2, NUCB2/nesfatin-1, ICAM-1, VCAM-1, MMP-3/13, degradation of type II collagen, and NF-kappaB activation through the rescue of IkappaBalpha. paeonol 44-51 interleukin 6 Homo sapiens 112-116 29981570-10 2018 Moreover, n-3PUFAs supplementation was associated with reduction in plasma levels of TNF-alpha [ES: - 0.59 (- 1.17, - 0.01); p = 0.045] and IL-6 (ES: - 1.67 (- 3.14, - 0.20); p = 0.026]. Fatty Acids, Omega-3 10-18 interleukin 6 Homo sapiens 140-144 31437565-9 2019 GLN increased the LC3-II protein expression and the number of acidic vesicular organelles, markers of autophagy, and blocked an increase in the NFkB protein expression in the nuclei and in the IL-6 gene expression caused by MEN. Glutamine 0-3 interleukin 6 Homo sapiens 193-197 30108645-6 2018 UV-B-irradiated NHDFs showed increased phosphorylation levels of JNK, p38 MAPK, and Akt, as well as increased mRNA levels of IL-6. nhdfs 16-21 interleukin 6 Homo sapiens 125-129 29707793-14 2018 IL-6-induced VEGF secretion was significantly suppressed by a PI3K inhibitor (LY294002) and it was accompanied by inhibited phosphorylation of Akt. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 78-86 interleukin 6 Homo sapiens 0-4 29794037-6 2018 Palmitate, but not palmitoleate, had mild effects on Akt phosphorylation but significantly inhibited insulin-stimulated GLUT4 translocation and increased expression of pro-inflammatory cytokines Il6 and Ccl2 Ceramides, hexosylceramides, and sphingosine-1-phosphate significantly heightened by palmitate correlated negatively with insulin sensitivity and positively with pro-inflammatory indices. Palmitates 0-9 interleukin 6 Homo sapiens 195-198 31526816-5 2019 WZ3146 also suppressed the production of histamine, tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, which mediate various allergic responses, in a dose-dependent manner. WZ3146 0-6 interleukin 6 Homo sapiens 90-108 29587234-9 2018 An increase in Factor 1 (+Fe, +Al, +Mn) score and a decrease in Factor 2 (-Ca, +Pb, +PAH) score were associated with increased interleukin (IL)-6 (Factor 1; p = 0.010; Factor 2; p = 0.006) and IL-8 (Factor 1; p = 0.003; Factor 2; p = 0.020) production, however, only the association with Factor 1 was evident after correcting for endotoxin and particle size. p-Aminohippuric Acid 85-88 interleukin 6 Homo sapiens 127-145 31276896-4 2019 Furthermore, the amine 4c, naphthoquinone 5, and azo-based 13 and 15 organic selenides were able to down-regulate the expression of Bcl-2 and up-regulate the expression levels of IL-2, IL-6 and CD40 in HepG2 cells compared to untreated cells. Naphthoquinones 27-41 interleukin 6 Homo sapiens 185-189 29896269-12 2018 In addition, IL-1and TNF-alpha were downregulated, while IL-6 and SOD were upregulated in patients with cognitive dysfunction after treatment with DEX compared with those in the placebo group. Dexmedetomidine 147-150 interleukin 6 Homo sapiens 57-61 28880691-4 2018 In 17 patients with serum IL-6 >= 30 pg/ml at 24 weeks, the proportion achieving CDAI remission was also significantly lower than 27 patients with serum IL-6 < 30 pg/ml then. cdai 84-88 interleukin 6 Homo sapiens 26-30 31276896-4 2019 Furthermore, the amine 4c, naphthoquinone 5, and azo-based 13 and 15 organic selenides were able to down-regulate the expression of Bcl-2 and up-regulate the expression levels of IL-2, IL-6 and CD40 in HepG2 cells compared to untreated cells. selenides 77-86 interleukin 6 Homo sapiens 185-189 28923363-4 2018 In fact, pure flavonoids (e.g., quercetin, genistein, hesperetin, epigallocatechin-3-gallate) or enriched-extracts, can reduce the expression of pro-inflammatory cytokines (IL-6, TNF-alpha, IL-1beta and COX-2), down-regulate inflammatory markers and prevent neural damage. Genistein 43-52 interleukin 6 Homo sapiens 173-177 31001928-10 2019 This study suggests that PBM accelerates tooth movement during molar intrusion, due to modulation of IL-6, IL-8 and IL-1beta during bone remodeling. pbm 25-28 interleukin 6 Homo sapiens 101-105 29583060-7 2018 RESULTS: The results showed that PAPep effectively decreased mRNA and protein expression of IL-6, MCP-1, and IFN-gamma in corneal fibroblasts exposed to poly(I:C). poly 153-157 interleukin 6 Homo sapiens 92-96 29693152-0 2018 Genistein reduces the activation of AKT and EGFR, and the production of IL6 in cholangiocarcinoma cells involving estrogen and estrogen receptors. Genistein 0-9 interleukin 6 Homo sapiens 72-75 31327593-8 2019 These results indicated that the concentration of CSF IL-6 is associated with TAMs" infiltration level and may be a useful prognostic biomarker for the GBM patients. tams 78-82 interleukin 6 Homo sapiens 54-58 30541065-3 2019 Angiotensin receptor blockers and omega-3 polyunsaturated fatty acids (omega-3) may reduce IL-6 and may potentially improve physical function. omega-3 polyunsaturated fatty acids 34-69 interleukin 6 Homo sapiens 91-95 29345351-5 2018 K313 dose-dependently (5, 10, and 20 muM) inhibited LPS-stimulated nitric oxide (NO), interleukin (IL)-6, tumor necrosis factor (TNF)-alpha, and 3-nitrotyrosine (3-NT) production and significantly decreased the gene transcription levels of inducible nitric oxide (iNOS), IL-6, and TNF-alpha. palladium chloride 0-4 interleukin 6 Homo sapiens 86-104 29345351-5 2018 K313 dose-dependently (5, 10, and 20 muM) inhibited LPS-stimulated nitric oxide (NO), interleukin (IL)-6, tumor necrosis factor (TNF)-alpha, and 3-nitrotyrosine (3-NT) production and significantly decreased the gene transcription levels of inducible nitric oxide (iNOS), IL-6, and TNF-alpha. palladium chloride 0-4 interleukin 6 Homo sapiens 271-275 29610530-2 2018 We now demonstrate that exposure of cobalt and chromium NPs to BeWo cell barriers, an in vitro model of the human placenta, triggers impairment of the autophagic flux and release of interleukin-6. Cobalt 36-42 interleukin 6 Homo sapiens 182-195 31547271-6 2019 The average content of TNF alpha, VEGF-C, VEGF-A IL-6, and FGF2 decreased after the therapy with diosmin in a significant manner; with p < 0.001, p < 0.05, p < 0.05, p < 0.01, and p < 0.01, respectively, and a significant (p < 0.05) increase in the plasma angiostatin level after the three-month treatment was found. Diosmin 97-104 interleukin 6 Homo sapiens 49-53 29854627-4 2018 Thalidomide and carboplatin induced up-regulation of the expression of p53, tumor necrosis factor-alpha and interleukin-6 in brain and kidney. Thalidomide 0-11 interleukin 6 Homo sapiens 108-121 30013439-13 2018 Release of cytokines IL-1beta, IL-6, IL-10 and TNFalpha was induced by silica exposure and the induction of IL-1beta, IL-6 and TNFalpha was suppressed by the addition of TAK-242. Silicon Dioxide 71-77 interleukin 6 Homo sapiens 31-35 31402961-12 2019 Dexmedetomidine can significantly improve postoperative cognitive dysfunction in elderly patients with colorectal cancer, and the occurrence of cognitive dysfunction can be affected by age, duration of anesthesia, intraoperative blood loss and the high expression of IL-6 and S-100beta. Dexmedetomidine 0-15 interleukin 6 Homo sapiens 267-271 29754770-4 2018 We characterized the phenotype and the function of DCs matured in the presence of sulprostone as a potential substitute of dinoprostone in the pro-inflammatory maturation cocktail consisting of tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and IL-6. sulprostone 82-93 interleukin 6 Homo sapiens 269-273 29704732-3 2018 Paeonol pretreatment showed statistically significant reduction in alcohol-induced ROS, MDA, IL-1beta, IL-6, TNF-alpha, and nitric oxide, while GSH content was retained (P < 0.05). paeonol 0-7 interleukin 6 Homo sapiens 103-107 29393444-0 2018 Tyrphostin B42 attenuates trichostatin A-mediated resistance in pancreatic cancer cells by antagonizing IL-6/JAK2/STAT3 signaling. trichostatin A 26-40 interleukin 6 Homo sapiens 104-108 29393444-5 2018 This over-proliferative activity induced by TSA may be associated with abnormal activation of JAK2/STAT3 signaling, which can be strengthened by interleukin-6 (IL-6), a STAT3-upstream inducer, resulting in enhanced expression of STAT3-downstream target genes including c-Myc, c-Src, HIF-1alpha, and CCND1. trichostatin A 44-47 interleukin 6 Homo sapiens 145-158 29393444-5 2018 This over-proliferative activity induced by TSA may be associated with abnormal activation of JAK2/STAT3 signaling, which can be strengthened by interleukin-6 (IL-6), a STAT3-upstream inducer, resulting in enhanced expression of STAT3-downstream target genes including c-Myc, c-Src, HIF-1alpha, and CCND1. trichostatin A 44-47 interleukin 6 Homo sapiens 160-164 29393444-10 2018 Therefore, these findings demonstrated that tyrphostin B42 attenuated TSA-mediated resistance in PCCs by antagonizing the IL-6/JAK2/STAT3 signaling. trichostatin A 70-73 interleukin 6 Homo sapiens 122-126 29271576-11 2018 This suggested that there is insufficient evidence to conclude the benefit of omega-3 fatty acids oral supplementation in reducing serum levels of CRP, IL-6 and TNF-alpha in patients with CKD. Fatty Acids, Omega-3 78-97 interleukin 6 Homo sapiens 152-156 32440504-0 2020 Genistein inhibits angiogenesis developed during rheumatoid arthritis through the IL-6/JAK2/STAT3/VEGF signalling pathway. Genistein 0-9 interleukin 6 Homo sapiens 82-86 29493374-4 2018 OBJECTIVE: This study investigated the effect of celastrol on mRNA expression and concentration levels of the pro-inflammatory cytokines tumor necrosis factor alpha (TNFalpha) and interleukin-6 (IL6) that are induced by influenza A/Puerto Rico/8/34 (H1N1; PR8) in Madin-Darby Canine Kidney (MDCK) cells. celastrol 49-58 interleukin 6 Homo sapiens 195-198 29493374-9 2018 RESULTS: mRNA expression and concentrations of TNFalpha and IL6 increased significantly in control virus compared to cell control, and decreased significantly when compared with control virus after celastrol treatment. celastrol 198-207 interleukin 6 Homo sapiens 60-63 29493374-11 2018 CONCLUSION: Due to reducing mRNA expression and concentrations of TNFalpha and IL6, celastrol can serve as a suitable choice to control cytokine-induced inflammation in IAV infection, and therefore it can be used with current antiviral drugs. celastrol 84-93 interleukin 6 Homo sapiens 79-82 33418784-7 2018 In contrast to class C CpG ODNs, which also simultaneously induce IFN-alpha and IL-6, the ratio of IFN-alpha and IL-6 induced by PEI-CpG ODN NPs could be regulated by changing the N/P ratio. Phosphorus 129-130 interleukin 6 Homo sapiens 113-117 32440504-6 2020 Results: GEN dose-dependently inhibited the expression and secretion of interleukin (IL)-6 and VEGF, as well as the nucleus translocation of Signal transducer and activator of transcription 3 (STAT3) in MH7A. Genistein 9-12 interleukin 6 Homo sapiens 72-90 31677539-6 2019 Studies showed that IL-6 and TNF-alpha activate phospholipases to induce the release of polyunsaturated fatty acids (PUFAs) from the cell membrane phospholipid pool. Fatty Acids, Unsaturated 88-115 interleukin 6 Homo sapiens 20-24 29274621-5 2018 The hypothesis of this study was that cannabinoids anandamide (AEA), HU-308 (CB2R selective agonist), and SMM-189 decrease pro-inflammatory IL-6 and MCP-1 production by primary human periodontal ligament fibroblasts (hPDLFs) stimulated with P. gingivalis LPS, TNF-alpha, or IL-1beta. anandamide 51-61 interleukin 6 Homo sapiens 140-144 29274621-5 2018 The hypothesis of this study was that cannabinoids anandamide (AEA), HU-308 (CB2R selective agonist), and SMM-189 decrease pro-inflammatory IL-6 and MCP-1 production by primary human periodontal ligament fibroblasts (hPDLFs) stimulated with P. gingivalis LPS, TNF-alpha, or IL-1beta. anandamide 63-66 interleukin 6 Homo sapiens 140-144 29413957-7 2018 2-ClHA and its alkyne analogue interfered with protein palmitoylation, induced ER-stress markers, reduced the ER ATP content, and activated transcription and secretion of interleukin (IL)-6 as well as IL-8. Alkynes 15-21 interleukin 6 Homo sapiens 171-189 31677539-6 2019 Studies showed that IL-6 and TNF-alpha activate phospholipases to induce the release of polyunsaturated fatty acids (PUFAs) from the cell membrane phospholipid pool. Fatty Acids, Unsaturated 117-122 interleukin 6 Homo sapiens 20-24 29853785-8 2018 In addition, plasma interleukin-6 was higher in the saline group than in the dexmedetomidine group at postoperative day 1 [118.8 (68.8) versus 78.5 (58.8) pg.ml-1, p = 0.0271]. Dexmedetomidine 77-92 interleukin 6 Homo sapiens 20-33 31677539-7 2019 PUFAs form precursors to pro- and anti-inflammatory eicosanoids and are capable of suppressing IL-6 and TNF-alpha excess production. Fatty Acids, Unsaturated 0-5 interleukin 6 Homo sapiens 95-99 29456111-2 2018 Methyllucidone inhibited STAT3 phosphorylation at tyrosine 705 in a dose- and time dependent manner in DU145 prostate cancer cells and suppressed IL-6-induced STAT3 phosphorylation at Tyr-705 in LNCaP cells. methyllucidone 0-14 interleukin 6 Homo sapiens 146-150 31098925-3 2019 We sought preliminary evidence as to whether pyridostigmine could improve proximal gastrointestinal motility, reduce SIBO, reduce plasma sCD14 (a marker of macrophage activation and indirect measure of translocation), and reduce the inflammatory cytokines IL-6 and TNFalpha in patients with HIV-AN. Pyridostigmine Bromide 45-59 interleukin 6 Homo sapiens 256-260 29373553-5 2018 Using this glioma model, here we analyze the effects of the phenolic compounds oleuropein and hydroxytyrosol in circulating RAS-regulating ASAP, APA, APN, APB and IRAP specific activities and the pro-inflammatory cytokines IL-6 and TNFalpha to understand the relationship between the antitumor and anti-inflammatory effects of hydroxytyrosol, but not oleuropein, and the components of the RAS. 3,4-dihydroxyphenylethanol 94-108 interleukin 6 Homo sapiens 223-227 29998870-7 2018 Results: In men, IL-6 had a significant (P <0.05) positive association with total omega-3 polyunsaturated fatty acids (PUFAs). omega-3 polyunsaturated fatty acids 85-120 interleukin 6 Homo sapiens 17-21 29998870-7 2018 Results: In men, IL-6 had a significant (P <0.05) positive association with total omega-3 polyunsaturated fatty acids (PUFAs). Fatty Acids, Unsaturated 122-127 interleukin 6 Homo sapiens 17-21 29998870-8 2018 In women, TNF-alpha had a significant positive association with total omega-3 (P <0.05) and omega-6 (P <0.01) PUFAs, IL-6 had a significant (P <0.05) positive association with total monounsaturated fatty acids and MCP-1 had a significant positive association with total trans-fatty acids (P <0.05). Trans Fatty Acids 279-296 interleukin 6 Homo sapiens 123-127 31349736-3 2019 Pretreatments with Rif and RifQ reduced the secretion of prototypical inflammatory cytokines (TNF- , IL-6) and the burst of oxidative stress in microglial cells activated with alphaS fibrillary aggregates. dehydrorifampicin 27-31 interleukin 6 Homo sapiens 101-105 29507367-3 2018 Through iterated cycles of polymer translation, selection and reverse translation, we discovered HFNAPs that bind proprotein convertase subtilisin/kexin type 9 (PCSK9) and interleukin-6, two protein targets implicated in human diseases. Polymers 27-34 interleukin 6 Homo sapiens 172-185 29274621-9 2018 LPS (1 mug/ml), TNF-alpha (10 ng/ml), and IL-1beta (1 ng/ml) increased IL-6 and MCP-1 production, which were inhibited by AEA, SMM-189, and HU-308. anandamide 122-125 interleukin 6 Homo sapiens 71-75 29274621-10 2018 AEA alone significantly increased IL-6, but not MCP-1 levels, but the other cannabinoids alone had no effect. anandamide 0-3 interleukin 6 Homo sapiens 34-38 28945228-0 2018 ERK-dependent IL-6 autocrine signaling mediates adaptive resistance to pan-PI3K inhibitor BKM120 in head and neck squamous cell carcinoma. NVP-BKM120 90-96 interleukin 6 Homo sapiens 14-18 28945228-4 2018 Treatment of NVP-BKM120, a pan-PI3K inhibitor, led to upregulation of interleukin-6 (IL-6) and subsequent activation of either extracellular signal-regulated kinase (ERK) or signal transducers and activators of transcription 3 (STAT3), causing modest antitumor effects on the growth of HNSCC cells. NVP-BKM120 17-23 interleukin 6 Homo sapiens 70-83 28945228-4 2018 Treatment of NVP-BKM120, a pan-PI3K inhibitor, led to upregulation of interleukin-6 (IL-6) and subsequent activation of either extracellular signal-regulated kinase (ERK) or signal transducers and activators of transcription 3 (STAT3), causing modest antitumor effects on the growth of HNSCC cells. NVP-BKM120 17-23 interleukin 6 Homo sapiens 85-89 29321495-5 2018 Moreover, treatment with STS (10 mug/ml) reduced CS extract (CSE)-induced IL-6 and IL-8 secretion in human bronchial epithelial (16HBE) cells. tanshinone II A sodium sulfonate 25-28 interleukin 6 Homo sapiens 74-78 30903189-4 2019 Nd2O3 exposure initiated an inflammatory response in 16HBE cells via the release of the proinflammatory cytokines interleukin (IL)-6 and IL-8. neodymium oxide 0-5 interleukin 6 Homo sapiens 114-132 29321495-5 2018 Moreover, treatment with STS (10 mug/ml) reduced CS extract (CSE)-induced IL-6 and IL-8 secretion in human bronchial epithelial (16HBE) cells. Cesium 49-51 interleukin 6 Homo sapiens 74-78 29938621-0 2018 A Novel Combination of omega-3 Fatty Acids and Nano-Curcumin Modulates Interleukin-6 Gene Expression and High Sensitivity C-reactive Protein Serum Levels in Patients with Migraine: A Randomized Clinical Trial Study. Fatty Acids, Omega-3 23-42 interleukin 6 Homo sapiens 71-84 29938621-2 2018 Curcumin and omega-3 fatty acids can exert neuroprotective effects through modulation of IL-6 gene expression and CRP levels. Fatty Acids, Omega-3 13-32 interleukin 6 Homo sapiens 89-93 29938621-3 2018 The aim of present study is the evaluation of combined effects of omega-3 fatty acids and nano-curcumin supplementation on IL-6 gene expression and serum level and hs-CRP levels in migraine patients. Fatty Acids, Omega-3 66-85 interleukin 6 Homo sapiens 123-127 29061481-7 2018 Furthermore, CQ pretreatment exacerbated palmitate-induced TNF-alpha and IL-6 mRNA expression in PBMCs. Palmitates 41-50 interleukin 6 Homo sapiens 73-77 29061481-9 2018 The induction of autophagy also led to a further increase in palmitate-induced expression of TNF-alpha and IL-6. Palmitates 61-70 interleukin 6 Homo sapiens 107-111 31074547-6 2019 Our results demonstrated that HES decreased the levels of TNF-alpha and IL-6, attenuated the glucose content in culture medium and increased glucose uptake in insulin-resistant HepG2 cells in vitro. Hesperidin 30-33 interleukin 6 Homo sapiens 72-76 29120088-7 2018 The results suggest a significant increase in IL-6 level at all the stages in BCP as compared to control group. bcp 78-81 interleukin 6 Homo sapiens 46-50 29319364-7 2018 In both diseases, the lowest levels of IL-6 and IL-33 were found in EBC. NSC638702 68-71 interleukin 6 Homo sapiens 39-43 29938621-6 2018 RESULTS: The results showed that both of omega-3 and nano-curcumin down-regulated IL-6 mRAN and significantly decreased the serum concentration. Fatty Acids, Omega-3 41-48 interleukin 6 Homo sapiens 82-86 29953997-6 2018 Sublethal concentrations of CDDO-me suppressed STAT3 activation by W4P-LHB ectopic expression and interleukin-6 treatment in W4P-LHB-NIH3T3 and Huh7 cells respectively. bardoxolone methyl 28-35 interleukin 6 Homo sapiens 98-111 31156337-6 2019 Results: When compared to the control group, TNF-alpha and IL-6 levels were significantly high compatible with the increase of DMAc levels, in the exposed groups. acetyl 2,3-dioxopropanal-di-(4,4-dimethylthiosemicarbazone) 127-131 interleukin 6 Homo sapiens 59-63 28914726-10 2018 From pretreatment to posttreatment, CBTI-BP compared with psychoeducation was associated with a nonsignificant, large effect size decrease in IL-6 (z = -1.61, p = .13, d = -0.78) and a nonsignificant, small-medium effect size decrease in sTNF-R2 (z = -0.79, p = .44, d = -0.38). cbti 36-40 interleukin 6 Homo sapiens 142-146 30743203-8 2019 The inhibitory effect of genistein on the expression of IL-6, IL-23 and TNF-alpha was weakened after Stat3 siRNA in HaCaT cells. Genistein 25-34 interleukin 6 Homo sapiens 56-60 29594564-0 2017 Photoelectrochemical immunoassay for human interleukin 6 based on the use of perovskite-type LaFeO3 nanoparticles on fluorine-doped tin oxide glass. Fluorine 117-125 interleukin 6 Homo sapiens 43-56 30295316-13 2019 G-HSA or HSA when combined with IL-1beta or IL-1beta + IL-17 synergistically stimulated IL-6 and IL-8. g-hsa 0-5 interleukin 6 Homo sapiens 88-92 30668316-8 2019 RESULTS: The results showed that terpenes have promising biological effects in relation to the treatment of arthritis, with the 24 terpenes identified in our survey being effective in the modulation of inflammatory mediators important to the physiopathology of arthritis, such as IL-6, IL-17, TNF-alpha, NFkappaB, and COX-2, among others. Terpenes 131-139 interleukin 6 Homo sapiens 280-284 29028602-5 2017 In A549 epithelium model, exposure to ZnO NPs induced cytotoxicity and decreased the release of interleukin 6 (IL-6) without a significant effect on epithelial permeability rate. Zinc Oxide 38-41 interleukin 6 Homo sapiens 96-109 29028602-5 2017 In A549 epithelium model, exposure to ZnO NPs induced cytotoxicity and decreased the release of interleukin 6 (IL-6) without a significant effect on epithelial permeability rate. Zinc Oxide 38-41 interleukin 6 Homo sapiens 111-115 29028602-6 2017 Co-exposure of A549 cells or A549 epithelium model to DPPC and ZnO NPs induced a higher release of lactate dehydrogenase (LDH) and interleukin-6 (IL-6) compared with the exposure of ZnO NPs alone. Zinc Oxide 63-66 interleukin 6 Homo sapiens 131-144 29028602-6 2017 Co-exposure of A549 cells or A549 epithelium model to DPPC and ZnO NPs induced a higher release of lactate dehydrogenase (LDH) and interleukin-6 (IL-6) compared with the exposure of ZnO NPs alone. Zinc Oxide 63-66 interleukin 6 Homo sapiens 146-150 30594048-9 2019 PNU-282987, an alpha7nAChR agonist, significantly decreased TNF-alpha, IL-1beta, and IL-6 but increased IL-10 in the monocyte culture supernatant of active LN patients, which were abolished by an alpha7nAChR antagonist methyllycaconitine. N-neopentyl-N-nitrosourea 0-3 interleukin 6 Homo sapiens 85-89 28916286-9 2017 However, even at low concentrations, primycin-sulphate affected gene expressions by up-regulating inflammatory cytokines (e.g., IL6), chemokines (e.g., CXCL5) and by down-regulating molecules of the lipid metabolism (e.g., peroxisome proliferator receptor (PPAR) alpha, gamma, etc). primycin 37-54 interleukin 6 Homo sapiens 128-131 30456555-9 2019 CaMK2 inhibition or knockdown ameliorated the BCP-induced changes in SOX9, IHH, COLX, IL-6 and MMP13 expression. bcp 46-49 interleukin 6 Homo sapiens 86-90 29066436-0 2017 Interleukin-6 and the Risk of Adverse Outcomes in Patients After an Acute Coronary Syndrome: Observations From the SOLID-TIMI 52 (Stabilization of Plaque Using Darapladib-Thrombolysis in Myocardial Infarction 52) Trial. darapladib 160-170 interleukin 6 Homo sapiens 0-13 29066436-3 2017 METHODS AND RESULTS: IL-6 concentration was assessed at baseline in 4939 subjects in SOLID-TIMI 52 (Stabilization of Plaque Using Darapladib-Thrombolysis in Myocardial Infarction 52), a randomized trial of darapladib in patients <=30 days from ACS. darapladib 130-140 interleukin 6 Homo sapiens 21-25 29066436-3 2017 METHODS AND RESULTS: IL-6 concentration was assessed at baseline in 4939 subjects in SOLID-TIMI 52 (Stabilization of Plaque Using Darapladib-Thrombolysis in Myocardial Infarction 52), a randomized trial of darapladib in patients <=30 days from ACS. darapladib 206-216 interleukin 6 Homo sapiens 21-25 30837047-8 2019 Thus,there was a positive correlation between NT-proBNP and IL-6 levels (r=0.876,P=0.000) and a positive correlation between NT-proBNP and PAP (r=0.916,P=0.000) in preterm infants with RDS.Conclusion Monitoring serum NT-proBN contributes to early diagnosis and disease severity assessment in preterm infants with RDS. nt-probn 46-54 interleukin 6 Homo sapiens 60-64 28697991-0 2017 Carbamazepine effects on pain management and serum IL-6, IL-10 evaluation in addicted patients undergoing surgery. Carbamazepine 0-13 interleukin 6 Homo sapiens 51-55 28697991-11 2017 Addition of carbamazepine improved pain sensation and serum IL-6 levels and a reduction in serum IL-10 level in control patients was paralleled to their recovery. Carbamazepine 12-25 interleukin 6 Homo sapiens 60-64 28550976-7 2017 The effect of anti-proliferative agent Mitomycin C upon secretion of pro-inflammatory cytokines IL-6 and IL-8 was assessed. Mitomycin 39-50 interleukin 6 Homo sapiens 96-100 30389635-9 2019 We report that celastrol particularly suppressed Pin1 expression, thereby inhibiting Akt, STAT3, P38, JNK, P65, and IL-6 expression. celastrol 15-24 interleukin 6 Homo sapiens 116-120 28928376-7 2017 Furthermore, Oligo-Fucoidan supplementation increases cancer cell death and attenuates the adverse effects induced by etoposide that decreases production of the pro-inflammatory cytokine IL-6 and chemokine CCL2/MCP-1. Etoposide 118-127 interleukin 6 Homo sapiens 187-191 31562632-5 2019 Additionally, EDP-EAs and EEQ-EAs dose-dependently decrease pro-inflammatory IL-6 cytokine and increased anti-inflammatory IL-10 cytokine. prostaglandin E2 ethanolamide 14-21 interleukin 6 Homo sapiens 77-81 28751572-7 2017 Positive associations were also observed for nitrogen oxides with interleukin-6 and for black carbon, sulfate, and ozone with tumor necrosis factor receptor 2. Nitrogen Oxides 45-60 interleukin 6 Homo sapiens 66-79 30365050-8 2019 In addition, cotreatment with the COX2 inhibitor CAY10404 and sesamin downregulated the expression of downstream molecules of COX2 [including interleukin (IL)1beta, IL6 and tumor necrosis factor alpha] compared with CAY10404 or sesamin alone. 3-(4-methylsulfonylphenyl)-4-phenyl-5-trifluoromethylisoxazole 49-57 interleukin 6 Homo sapiens 165-168 28656237-0 2017 Matrine increases the inhibitory effects of afatinib on H1975 cells via the IL-6/JAK1/STAT3 signaling pathway. Afatinib 44-52 interleukin 6 Homo sapiens 76-80 30518684-8 2018 IL-6 neutralizing antibody (IL-6-Nab) combined with HMA fully eradicated OCSC, and the combination blocked IL-6/IL6-R/pSTAT3-mediated ALDH1A1 expression and eliminated OCSC in residual tumors that persisted in vivo after chemotherapy. nab 33-36 interleukin 6 Homo sapiens 0-4 30518684-8 2018 IL-6 neutralizing antibody (IL-6-Nab) combined with HMA fully eradicated OCSC, and the combination blocked IL-6/IL6-R/pSTAT3-mediated ALDH1A1 expression and eliminated OCSC in residual tumors that persisted in vivo after chemotherapy. nab 33-36 interleukin 6 Homo sapiens 28-32 30518684-8 2018 IL-6 neutralizing antibody (IL-6-Nab) combined with HMA fully eradicated OCSC, and the combination blocked IL-6/IL6-R/pSTAT3-mediated ALDH1A1 expression and eliminated OCSC in residual tumors that persisted in vivo after chemotherapy. nab 33-36 interleukin 6 Homo sapiens 28-32 30584292-6 2018 The PImax, TAC, IL-6, total QoL score, and 6MWD changed significantly in the SDBT group after the 4-week experiment as compared to those in the pre-experimental period, whereas FVC, FEV1, FEV1%, FEV1/FVC%, PImax, TAC, MDA, NO, TNF-alpha, IL-6, 6MWD, and total CCQ score changed significantly in the FDBT group as compared to those in the pre-experimental period. sdbt 77-81 interleukin 6 Homo sapiens 16-20 28799079-7 2017 Pretreatment with paeonol significantly suppressed the production of pro-inflammatory TNF-alpha, IL-6 and IL-1beta, and the expressions of matrix metalloproteinase-1/-3 in vitro and in vivo. paeonol 18-25 interleukin 6 Homo sapiens 97-101 30584292-6 2018 The PImax, TAC, IL-6, total QoL score, and 6MWD changed significantly in the SDBT group after the 4-week experiment as compared to those in the pre-experimental period, whereas FVC, FEV1, FEV1%, FEV1/FVC%, PImax, TAC, MDA, NO, TNF-alpha, IL-6, 6MWD, and total CCQ score changed significantly in the FDBT group as compared to those in the pre-experimental period. sdbt 77-81 interleukin 6 Homo sapiens 238-242 30439604-7 2018 Additionally, HG-elevated high transcripts and secretions of pro-inflammatory cytokines were reversed following celastrol treatment, including IL-1beta, TNF-alpha, IL-6. celastrol 112-121 interleukin 6 Homo sapiens 164-168 28714512-6 2017 Our data showed that UA inhibited the P-STAT3 induced by interleukin-6 (IL-6) in Hep3B liver cancer cells which express very low basal level of P-STAT3. ursolic acid 21-23 interleukin 6 Homo sapiens 57-70 28714512-6 2017 Our data showed that UA inhibited the P-STAT3 induced by interleukin-6 (IL-6) in Hep3B liver cancer cells which express very low basal level of P-STAT3. ursolic acid 21-23 interleukin 6 Homo sapiens 72-76 30527263-2 2018 We hypothesized that completing a 12-week omega-3 supplementation period along with whole body resistance exercise (3 times/wk) would result in a significantly greater improvement in lean tissue mass as well as a significant decrease in interleukin-6 and tumor necrosis factor-alpha when compared to placebo. Fatty Acids, Omega-3 42-49 interleukin 6 Homo sapiens 237-282 28371277-7 2017 The miR-138 mimic and LY294002 groups showed decreased concentrations of TNF-alpha, IL-6, IL-8 and NO and reduced activities of LDH and eNOS, while opposite trends were observed in the miR-138 inhibitor group. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 22-30 interleukin 6 Homo sapiens 84-88 28677802-0 2017 Norcantharidin inhibits IL-6-induced epithelial-mesenchymal transition via the JAK2/STAT3/TWIST signaling pathway in hepatocellular carcinoma cells. norcantharidin 0-14 interleukin 6 Homo sapiens 24-28 30391912-10 2018 These results might be attributed to inhibition of inflammatory responses and the resulting lower serum levels of IL-6 and TNF-alpha, caused by Dex administration. Dexmedetomidine 144-147 interleukin 6 Homo sapiens 114-118 28969013-9 2017 Postoperative plasma IL-6 and cortisol levels were lower in dexmedetomidine(3 mug and 5 mug) co-administration groups. Dexmedetomidine 60-75 interleukin 6 Homo sapiens 21-25 30016150-9 2018 In C2C12 myotubes, only high palmitate concentrations (500-600 microM) elicited IL-6 secretion (>2.5-fold increase). Palmitates 29-38 interleukin 6 Homo sapiens 80-84 30261195-7 2018 Citomix was able to significantly increase the expression of B memory cells, IFN-gamma, IL-6, IgA and IgM, and significantly decrease IL-10 and IgG. citomix 0-7 interleukin 6 Homo sapiens 88-92 28292012-0 2017 Up regulation of IL-6 is involved in di (2-ethylhexyl) phthalate (DEHP) induced migration and invasion of non small cell lung cancer (NSCLC) cells. Diethylhexyl Phthalate 37-64 interleukin 6 Homo sapiens 17-21 28292012-0 2017 Up regulation of IL-6 is involved in di (2-ethylhexyl) phthalate (DEHP) induced migration and invasion of non small cell lung cancer (NSCLC) cells. Diethylhexyl Phthalate 66-70 interleukin 6 Homo sapiens 17-21 28292012-4 2017 DEHP treatment also increased the expression of interleukin-6 (IL-6) and IL-8. Diethylhexyl Phthalate 0-4 interleukin 6 Homo sapiens 48-61 28292012-4 2017 DEHP treatment also increased the expression of interleukin-6 (IL-6) and IL-8. Diethylhexyl Phthalate 0-4 interleukin 6 Homo sapiens 63-67 28292012-7 2017 The inhibitor of NF-kappaB, while not ERK1/2 or Akt, abolished DEHP induced up regulation of IL-6 and invasion of NSCLC cells. Diethylhexyl Phthalate 63-67 interleukin 6 Homo sapiens 93-97 30096092-7 2018 After 6 months of rifaximin therapy, patients with NASH showed a significant reduction in homeostatic model assessment, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, endotoxin, toll-like receptor-4, IL-6, tumor necrosis factor-alpha, CK-18, and NAFLD-liver fat score (all P<0.05), but no changes in the lipid profile; moreover, there was a mild nonstatistically significant reduction of BMI. Rifaximin 18-27 interleukin 6 Homo sapiens 235-268 28272402-3 2017 Enteral glutamine resulted in modulation of inflammatory and hormonal responses as shown by a decreased plasma interleukin 6 and cortisol levels in glutamine compared with placebo group: 5.5+-3.8 versus 11.1+-19.9 ng/l (P=0.02) for IL-6 and 386+-168.4 to 312.7+-111.7 nmol/l (P=0.03) for cortisol. Glutamine 8-17 interleukin 6 Homo sapiens 111-124 28272402-3 2017 Enteral glutamine resulted in modulation of inflammatory and hormonal responses as shown by a decreased plasma interleukin 6 and cortisol levels in glutamine compared with placebo group: 5.5+-3.8 versus 11.1+-19.9 ng/l (P=0.02) for IL-6 and 386+-168.4 to 312.7+-111.7 nmol/l (P=0.03) for cortisol. Glutamine 8-17 interleukin 6 Homo sapiens 232-236 28272402-3 2017 Enteral glutamine resulted in modulation of inflammatory and hormonal responses as shown by a decreased plasma interleukin 6 and cortisol levels in glutamine compared with placebo group: 5.5+-3.8 versus 11.1+-19.9 ng/l (P=0.02) for IL-6 and 386+-168.4 to 312.7+-111.7 nmol/l (P=0.03) for cortisol. Glutamine 148-157 interleukin 6 Homo sapiens 111-124 30516500-3 2018 In patients with CHC, the genotype CC of the polymorphism of the IL-6 gene was associated with fluctuations in the concentration of IL-6 in the blood within the reference range, which was prognostically favorable for the formation of SVR 24 for AVT according to the peg-IFNalpha + SOF + RBV. sof 281-284 interleukin 6 Homo sapiens 65-69 27838193-0 2017 Plasma Levels of Marine n-3 Fatty Acids Are Inversely Correlated With Proinflammatory Markers sTNFR1 and IL-6 in Renal Transplant Recipients. Fatty Acids, Omega-3 24-39 interleukin 6 Homo sapiens 105-109 27838193-9 2017 RESULTS: Plasma marine n-3 PUFA levels were inversely associated with plasma levels of proinflammatory biomarkers soluble tumor necrosis factor receptor 1 (standardized regression coefficient -0.11, P < .001) and interleukin-6 (standardized regression coefficient -0.09, P = .01). Fatty Acids, Unsaturated 27-31 interleukin 6 Homo sapiens 216-229 30516500-3 2018 In patients with CHC, the genotype CC of the polymorphism of the IL-6 gene was associated with fluctuations in the concentration of IL-6 in the blood within the reference range, which was prognostically favorable for the formation of SVR 24 for AVT according to the peg-IFNalpha + SOF + RBV. sof 281-284 interleukin 6 Homo sapiens 132-136 30076857-6 2018 Palmitate significantly increased TNF-alpha and IL-6 expression and secretion in THP-1 and RAW 264.7 macrophages. Palmitates 0-9 interleukin 6 Homo sapiens 48-52 28616923-9 2017 CONCLUSIONS: The tramadol can attenuate IR during cesarean section complicated with GDM and may regulate the secretion of IL-6, TNF-alpha and PI3K/Akt signaling pathway in the treatment of IR of GDM. Tramadol 17-25 interleukin 6 Homo sapiens 122-126 30076857-7 2018 Treatment with the active form of vitamin D inhibited palmitate-induced TNF-alpha and IL-6 production in macrophages. Palmitates 54-63 interleukin 6 Homo sapiens 86-90 30076857-10 2018 Our data suggest that the attenuation of palmitate-induced TNF-alpha and IL-6 gene expression and protein secretion by vitamin D are associated with reduced activation of JNK and ERK1/2. Palmitates 41-50 interleukin 6 Homo sapiens 73-77 29882996-8 2018 Finally, results showed that targeting S1P receptors using either S1P receptor antagonists or small interfering RNA attenuated IL-6 upregulation by LPS and palmitate. Palmitates 156-165 interleukin 6 Homo sapiens 127-131 28285690-11 2017 CS-induced STAT3 activation in SCLC cells was suppressed by anti-IL-6 receptor antibody, but not by anti-CCL4/MIP-1beta antibody. Cesium 0-2 interleukin 6 Homo sapiens 65-69 27827528-9 2017 Moreover, PBSu and PBSu/TCP significantly suppressed the expression of IL-1beta and IL-6 genes by 15-35% and 21-26%, respectively. tcp 24-27 interleukin 6 Homo sapiens 84-88 30254419-4 2018 Geraniol was found to inhibit both TNF-alpha, IL-1beta and IL-6 protein and mRNA expressions at concentrations of 40, 80, 160 muM. geraniol 0-8 interleukin 6 Homo sapiens 59-63 26704762-1 2017 OBJECTIVE: The objective was to investigate the benefits of supplementing enteral feeding with omega-3 fatty acids in children with mild to moderate sepsis and its effects on acute-phase reactants and interleukin 6 (IL-6) level. Fatty Acids, Omega-3 95-114 interleukin 6 Homo sapiens 216-220 30078983-10 2018 Both CE-CKC emulsions inhibited the secretion of IL-17 (from anti-CD3/anti-CD28-stimulated TCD4), TNFalpha, IFN-gamma, and IL-2 (from anti-CD3-/anti-CD28-stimulated PBMCs), and IL-6 and IL-8 (from LPS-stimulated HCE-2). ce-ckc 5-11 interleukin 6 Homo sapiens 177-181 28013248-9 2017 The association between tryptophan oxidation and CNS inflammatory responses as measured by CSF interleukin 6 (IL-6) concentration supports a role of kynurenine metabolites in the inflammatory pathogenesis of late-stage HAT. Kynurenine 149-159 interleukin 6 Homo sapiens 110-114 28840599-6 2018 IL-6 secretion was examined after 24 hour, 48 hour or 6 day exposures to TBT and DBT in highly enriched human natural killer cells, monocyte-depleted peripheral blood mononuclear cells (PBMCs), PBMCs, granulocytes and a preparation combining both PBMCs and granulocytes (PBMCs + granulocytes). di-n-butyltin 81-84 interleukin 6 Homo sapiens 0-4 30012134-0 2018 Curcumin derivative, 2,6-bis(2-fluorobenzylidene)cyclohexanone (MS65) inhibits interleukin-6 production through suppression of NF-kappaB and MAPK pathways in histamine-induced human keratinocytes cell (HaCaT). 2,6-Bis(2-Fluorobenzylidene)Cyclohexanone 21-62 interleukin 6 Homo sapiens 79-92 28840599-8 2018 Significant decreases of IL-6 secretion were seen at the highest concentration of TBT (200 nm) and DBT (5-2.5 mum) while the lower concentrations of DBT (0.05 and 0.1 mum) caused elevation of IL-6 secretion. di-n-butyltin 99-102 interleukin 6 Homo sapiens 25-29 28840599-8 2018 Significant decreases of IL-6 secretion were seen at the highest concentration of TBT (200 nm) and DBT (5-2.5 mum) while the lower concentrations of DBT (0.05 and 0.1 mum) caused elevation of IL-6 secretion. di-n-butyltin 149-152 interleukin 6 Homo sapiens 192-196 29229421-2 2018 BA-25 (3-alpha-o-acetoxy-4beta-amino-11-oxo-24-norurs-12-ene) an amino analogue of beta-boswellic acid exhibited inhibition of TNF-alpha and IL-6 in THP-1 cells as demonstrated previously, however, the effect on principal inflammatory mediators such as cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) and the pathways that mediate this function remains unknown. 3-alpha-o-acetoxy-4beta-amino-11-oxo-24-norurs-12-ene 7-60 interleukin 6 Homo sapiens 141-145 28945228-5 2018 Blockade of autocrine IL-6 signaling with siRNA or neutralizing antibody for IL-6 receptor (IL-6R) completely abolished NVP-BKM120-induced activation of ERK and STAT3 as well as expression of c-Myc oncogene, which resulted in enhanced sensitivity to NVP-BKM120. NVP-BKM120 124-130 interleukin 6 Homo sapiens 22-26 28945228-5 2018 Blockade of autocrine IL-6 signaling with siRNA or neutralizing antibody for IL-6 receptor (IL-6R) completely abolished NVP-BKM120-induced activation of ERK and STAT3 as well as expression of c-Myc oncogene, which resulted in enhanced sensitivity to NVP-BKM120. NVP-BKM120 254-260 interleukin 6 Homo sapiens 22-26 28025169-7 2017 TG and PA significantly induced cytotoxicity and THP-1 adhesion as well as modestly promoted the release of IL-6, but did not affect ROS or release of sVCAM-1 and IL-8. Palmitates 7-9 interleukin 6 Homo sapiens 108-112 27665119-4 2017 The results showed that the mRNA expression of IL-1beta, IL-6 and TNF-alpha can be down-regulated by pre-treatment of TSA in LPS-stimulated broiler PBMC. trichostatin A 118-121 interleukin 6 Homo sapiens 57-61 29727764-6 2018 RESULTS: Serum IL-6 was significantly higher in patients with depressive symptoms compared to normal (20.47 +- 4.27 pg/mL for HADS-D >=11 versus 9.26 +- 1.59 pg/mL for HADS-D <7, p = 0.014). hads-d > 126-136 interleukin 6 Homo sapiens 15-19 29722127-8 2018 Application of the JAK2 inhibitor AZD1480 and IL6 neutralizing antibody showed the CD90 and SHH/Gli-regulated liver cancer stem cell functions were mediated by the IL6/JAK2/STAT3 pathway. AZD 1480 34-41 interleukin 6 Homo sapiens 164-167 30589029-3 2018 We hypothesized that DEX could reduce the incidence of POCD caused by sevoflurane anesthesia through decreasing plasma interleukin (IL-6) and tumor necrosis factor (TNF)-alpha concentrations. Dexmedetomidine 21-24 interleukin 6 Homo sapiens 132-136 30589029-10 2018 Conclusion: The POCD incidence was higher in elderly patients receiving sevoflurane anesthesia and DEX could alleviate POCD in these patients through decreasing plasma TNF-alpha and IL-6 concentrations. Dexmedetomidine 99-102 interleukin 6 Homo sapiens 182-186 28134246-5 2017 At the cellular level, VHH6 was able to alter the response of endothelial cells to exogenous IL-6, promoting a sustained STAT3 phosphorylation signal, an accumulation of IL-6 in vesicles and an overall pro-inflammatory phenotype supported further by transcriptomic analysis. vhh6 23-27 interleukin 6 Homo sapiens 93-97 28134246-5 2017 At the cellular level, VHH6 was able to alter the response of endothelial cells to exogenous IL-6, promoting a sustained STAT3 phosphorylation signal, an accumulation of IL-6 in vesicles and an overall pro-inflammatory phenotype supported further by transcriptomic analysis. vhh6 23-27 interleukin 6 Homo sapiens 170-174 28118841-4 2017 RESULTS: We show that copper deficiency and the inflammatory cytokine interleukin-6 have different effects on the expression of proteins involved in iron and copper metabolism such as the soluble and glycosylphosphtidylinositol anchored forms of ceruloplasmin, hepcidin, ferroportin1, transferrin receptor1, divalent metal transporter1 and H-ferritin subunit. glycosylphosphtidylinositol 200-227 interleukin 6 Homo sapiens 70-83 27995459-5 2018 In cultured cardiac myocytes, activation of Epac attenuated the inhibitory effect of interleukin-6 on the increase of intracellular Ca2+ concentration and contractility in response to isoproterenol, most likely through inhibition of the Jak-STAT pathway via SOCS3, with subsequent changes in inducible nitric oxide synthase expression. Isoproterenol 184-197 interleukin 6 Homo sapiens 85-98 29457280-8 2018 Besides, levels of PE750, PI885, PC792, PC826, PC830, PC854, PC802, and PG747 had an obvious negative correlation with levels of TNF-alpha, IL-10, IL-6, BUN, SCr, and PaCO2 , and a significant positive correlation with levels of HCO3- , PaO2 , and SaO2 . sao2 248-252 interleukin 6 Homo sapiens 147-151 29245201-8 2018 Postoperative levels of IL1-ss and IL-6 were lower in the allopurinol group. Allopurinol 58-69 interleukin 6 Homo sapiens 35-39 27871911-5 2017 In addition, we also showed that theaflavin-3,3"-digallate inhibited the expression of tumor necrosis factor alpha, interleukin -1 beta, and interleukin 6 in phorbol myristate acetate -primed U937 and RAW 264.7 cells. theaflavin-3,3'-digallate 33-58 interleukin 6 Homo sapiens 141-154 28923363-4 2018 In fact, pure flavonoids (e.g., quercetin, genistein, hesperetin, epigallocatechin-3-gallate) or enriched-extracts, can reduce the expression of pro-inflammatory cytokines (IL-6, TNF-alpha, IL-1beta and COX-2), down-regulate inflammatory markers and prevent neural damage. epigallocatechin gallate 66-92 interleukin 6 Homo sapiens 173-177 28857425-8 2018 The supplementation with MCP and omega-3 fatty acid also managed to reduce the level of IL-6 (P = 0.002). Fatty Acids, Omega-3 33-51 interleukin 6 Homo sapiens 88-92 27369643-12 2017 Because healthy donors show the same frequency of naive TCZ-specific and infliximab-specific CD4+ T cell precursors, the low prevalence of ADAs to TCZ might result from interleukin-6 blockade. dSMP 139-143 interleukin 6 Homo sapiens 169-182 28886428-4 2017 The results showed TCEP increased the percentage of SA-beta-Gal positive cells, decreased IL-6 levels, down-regulated the regulators of p38MAPK-NF-kappaB pathways, but up-regulated the regulators of p21Waf1/Cip1-Rb pathway in L02 cells. tris(chloroethyl)phosphate 19-23 interleukin 6 Homo sapiens 90-94 29334172-1 2018 We have previously reported that silica nanoparticles (SiNPs) of nominal size 50 nm (Si50) induce the pro-inflammatory cytokines CXCL8 and IL-6 in BEAS-2B cells, via mechanisms involving MAPK p38, TACE-mediated TGF-alpha release and the NF-kappaB pathway. Silicon Dioxide 33-39 interleukin 6 Homo sapiens 139-143 28864870-9 2017 Taken together, these findings indicate that GS25 elicits its anti-cancer effects on HepG2 cells through multiple mechanisms and has the potential to be used as an inhibitor of IL-6 signaling. gs25 45-49 interleukin 6 Homo sapiens 177-181 27245499-6 2017 The kynurenine pathway is also critically regulated by cytokines, and, indeed, the pro-inflammatory cytokines interleukin (IL)-1beta and IL-6 are elevated in schizophrenia and bipolar disorder and stimulate the production of kynurenic acid. Kynurenine 4-14 interleukin 6 Homo sapiens 137-141 29549829-6 2018 IL-6 levels in group D2 were significantly lower only at 1 h after surgery than in group S. However, IL-6 levels in delirious patients in group D2 were significantly lower at 1 h and 24 h after surgery than those in group S. Cortisol levels 1 h after surgery were significantly lower in groups D1 and D2 than in group S. CONCLUSIONS: The dose and timing of dexmedetomidine appeared to be important in preventing delirium. Dexmedetomidine 357-372 interleukin 6 Homo sapiens 101-105 28947926-7 2017 The treatment of oleate or MitoTEMPO to palmitate-conditioned myotubes led to inhibition of palmitate-induced mRNA expression of proinflammatory (TNF-alpha and IL6), mitochondrial fission (Drp1 and Fis1), and atrophy markers (myostatin and atrogin1). Palmitates 40-49 interleukin 6 Homo sapiens 160-163 28947926-7 2017 The treatment of oleate or MitoTEMPO to palmitate-conditioned myotubes led to inhibition of palmitate-induced mRNA expression of proinflammatory (TNF-alpha and IL6), mitochondrial fission (Drp1 and Fis1), and atrophy markers (myostatin and atrogin1). Palmitates 92-101 interleukin 6 Homo sapiens 160-163 26663823-9 2017 The GSH/GSSG ratio negatively correlated with IL-6 (P: 0.014), IL-8 (P: 0.014) and IL-10 (P: 0.033). Glutathione Disulfide 4-7 interleukin 6 Homo sapiens 46-50 26663823-9 2017 The GSH/GSSG ratio negatively correlated with IL-6 (P: 0.014), IL-8 (P: 0.014) and IL-10 (P: 0.033). Glutathione Disulfide 8-12 interleukin 6 Homo sapiens 46-50 28881218-8 2017 In addition, the histone deacetylase inhibitor trichostatin A increased miR-223 expression obviously in TLR-triggered macrophages, which in turn suppressed RhoB expression and downstream IL-6 production, suggesting that the inhibition of miR-223 by histone deacetylation may be involved in the regulation of TLR-activated inflammatory response. trichostatin A 47-61 interleukin 6 Homo sapiens 187-191 29549829-7 2018 The reduced incidence and duration of delirium by dexmedetomidine was associated with reduced levels of IL-6 24 h after surgery. Dexmedetomidine 50-65 interleukin 6 Homo sapiens 104-108 27825800-10 2016 DHL-HisZn treatment enhanced insulin signaling and inhibited NF-kappaB activation, which subsequently suppressed inflammatory cytokine IL-6 expression. zinc histidine dithiooctanamide 0-9 interleukin 6 Homo sapiens 135-139 29726680-0 2018 Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner. stilbenoids 8-19 interleukin 6 Homo sapiens 125-128 27811394-7 2016 Cytokines were screened in isoprenaline/salbutamol-treated recellularized liver, and the expression of IL-6 was significantly increased. Isoproterenol 27-39 interleukin 6 Homo sapiens 103-107 27811394-7 2016 Cytokines were screened in isoprenaline/salbutamol-treated recellularized liver, and the expression of IL-6 was significantly increased. Albuterol 40-50 interleukin 6 Homo sapiens 103-107 27811394-8 2016 Isoprenaline or salbutamol especially promoted the expression of Stat 3 and phosphorylated Stat 3, contributing to the activation of IL-6/Stat 3 signalling in promoting hepatocyte proliferation and recellularized liver function. Isoproterenol 0-12 interleukin 6 Homo sapiens 133-137 27811394-8 2016 Isoprenaline or salbutamol especially promoted the expression of Stat 3 and phosphorylated Stat 3, contributing to the activation of IL-6/Stat 3 signalling in promoting hepatocyte proliferation and recellularized liver function. Albuterol 16-26 interleukin 6 Homo sapiens 133-137 29042430-7 2017 In the controls, the mean concentrations of high-sensitivity C-reactive protein, IL-6, and fibrinogen decreased with higher CVH status. cvh 124-127 interleukin 6 Homo sapiens 81-85 28786289-11 2017 General linear model revealed the relation of LCACs (C16, C16:1, and C18:1) to the inflammatory markers (epidermal growth factor, IL-2, IL-4, IL-6), whereas SCAC C3 was linked to the metabolic markers (leptin, C-peptide) and BMI. lcacs 46-51 interleukin 6 Homo sapiens 142-146 29544935-6 2018 Interestingly, treatment of cells with fumarate induced oxidative stress, enhanced fibroblast activation markers and increased collagen and interleukin-6 secretion. Fumarates 39-47 interleukin 6 Homo sapiens 140-153 28736908-5 2017 Cobalt-treated monocytes/macrophages presented significantly elevated levels of interleukin 6 (IL-6) and tumor necrosis factor (TNF), both of which were suppressed by the addition of exogenous BMP-7. Cobalt 0-6 interleukin 6 Homo sapiens 80-93 28736908-5 2017 Cobalt-treated monocytes/macrophages presented significantly elevated levels of interleukin 6 (IL-6) and tumor necrosis factor (TNF), both of which were suppressed by the addition of exogenous BMP-7. Cobalt 0-6 interleukin 6 Homo sapiens 95-99 28736908-6 2017 In patients with TJA, the serum BMP-7 level was inversely associated with the level of IL-6 and TNF secreted by monocytes/macrophages. tja 17-20 interleukin 6 Homo sapiens 87-91 28736908-7 2017 Cobalt-treated monocytes/macrophages effectively supported Th17 inflammation, by an IL-6-dependent but not TNF-dependent mechanism. Cobalt 0-6 interleukin 6 Homo sapiens 84-88 29901960-1 2016 Objective: The present study aimed to investigate the anti-inflammatory effect of phytoestrogen genistein (Ge) on the secretion of interleukin 6 (IL6) under lipopolysaccharide (LPS) stimulated conditions in human endometrial epithelial cell line RL95-2. Genistein 96-105 interleukin 6 Homo sapiens 131-144 29901960-1 2016 Objective: The present study aimed to investigate the anti-inflammatory effect of phytoestrogen genistein (Ge) on the secretion of interleukin 6 (IL6) under lipopolysaccharide (LPS) stimulated conditions in human endometrial epithelial cell line RL95-2. Genistein 96-105 interleukin 6 Homo sapiens 146-149 27207443-6 2016 Additionally, the serum and saliva levels of IL-6, IL-17A, and NO were higher in the pSS patients, compared with the NCs. pss 85-88 interleukin 6 Homo sapiens 45-49 29567576-6 2018 UA administration decreased levels of proinflammatory markers, including interleukin-6 and tumor necrosis factor-alpha, in the injured spinal cord at the acute phase of inflammation and activated the mitogen-activated protein kinase and phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin pathways in the injured spinal cord. ursolic acid 0-2 interleukin 6 Homo sapiens 73-118 27418629-3 2016 METHODS AND RESULTS: In primary hepatocytes from healthy animals, metformin and the IKKbeta (inhibitor of kappa B kinase) inhibitor BI605906 both inhibited tumor necrosis factor-alpha-dependent IkappaB degradation and expression of proinflammatory mediators interleukin-6, interleukin-1beta, and CXCL1/2 (C-X-C motif ligand 1/2). BI605906 132-140 interleukin 6 Homo sapiens 258-271 28668524-8 2017 Serum IL-6 and TNF-alpha level in Dex group was significantly increased at T3 and T4 (P<0.05), and IL-6 and TNF-alpha level in control group was significantly increased at T2, T3, T4 and T5 (P<0.05) when compared with their respective preoperative levels (T1). Dexmedetomidine 34-37 interleukin 6 Homo sapiens 6-10 28668524-9 2017 IL-6 and TNF-alpha levels at T2, T3, T4 and T5 in Dex group were significantly lower than those in control group (P<0.05). Dexmedetomidine 50-53 interleukin 6 Homo sapiens 0-4 29543650-5 2018 Indoleamine 2,3-dioxygenase (IDO), the rate-limiting enzyme of the tryptophan catabolite (TRYCAT) pathway, is induced by interferon-gamma, interleukin-6, TNF-alpha, and oxidative stress. tryptophan catabolite 67-88 interleukin 6 Homo sapiens 139-152 28684418-7 2017 The HO-1 inducer cobalt protoporphyrin IX more efficiently attenuated PGE2 and IL-6 release in HG+IL-1beta-treated cells than in NG+IL-1beta-treated cells. Cobalt 17-23 interleukin 6 Homo sapiens 79-83 27259980-7 2016 Unlike intact VCAN, versikine-induced Il-6 production was partially independent of Tlr2. versikine 20-29 interleukin 6 Homo sapiens 38-42 29111391-9 2018 Inter-group comparison showed significant difference for TNF-alpha (p=0.024) and IL-6 (p=0.044) levels for aPDT group at 12 week follow-up. apdt 107-111 interleukin 6 Homo sapiens 81-85 27485319-12 2016 Glutamine showed inverse associations with CRP levels (r = -0.44, p < 0.05) and IL-6 concentrations (r = -0.23, p = 0.08). Glutamine 0-9 interleukin 6 Homo sapiens 83-87 28851867-5 2017 Exposure of DCs to the new class of triterpenoid CDDO-DFPA (RTA-408) results in the induction of HO-1, TGF-beta, and IL-10, as well as the repression of NF-kappaB, EDN-1 and pro-inflammatory cytokines IL-6, IL-12, and TNFalpha. triterpenoid TP-222 36-48 interleukin 6 Homo sapiens 201-205 28636034-6 2017 However, zinc(ii)-protoporphyrin IX (ZnPPIX), a selective inhibitor of HO-1, restored the GHP-mediated suppression of ROS production and NOX2, TNF-alpha, IL-1beta, IL-6 and iNOS expression. ghp 90-93 interleukin 6 Homo sapiens 164-168 28801702-7 2018 Then we curiously studied whether the aging MRC-5 cell-conditioned medium could induce EMT in premalignant HaCaT cells, and the results showed that paeonol significantly reduced the clonogenic, migratory, and invasive capacities of premalignant HaCaT cells potentially induced by IL-6 and IL-8. paeonol 148-155 interleukin 6 Homo sapiens 280-284 28525378-6 2017 Moreover, TSA inhibited the production of TNF-alpha and IL-6 in differentiated THP-1cells. trichostatin A 10-13 interleukin 6 Homo sapiens 56-60 27216197-8 2016 Unexpectedly, IL6-type cytokine signaling inducing STAT3 activation rendered cervical cancer cells significantly more susceptible to chemotherapeutic drugs, that is, cisplatin or etoposide. Etoposide 179-188 interleukin 6 Homo sapiens 14-17 29441020-4 2018 The elevated levels of IL-6, CRP, IL-8, and TNF-alpha were effectively reduced by EDT treatment. eriodictyol 82-85 interleukin 6 Homo sapiens 23-27 27327525-7 2016 Moreover, addition of Gas6 significantly suppressed silica induced TNF-alpha, IL-1beta and IL-6 levels in negative dose-dependent manners, not only in mRNA levels but also in protein levels. Silicon Dioxide 52-58 interleukin 6 Homo sapiens 91-95 27278808-15 2016 CONCLUSIONS: Pulmonary exposure to ZnO-coated MWCNTs produces a systemic acute phase response that involves the release of Zn(+2), lung epithelial growth arrest, and increased IL-6. Zinc Oxide 35-38 interleukin 6 Homo sapiens 176-180 28504465-6 2017 Because the binding of SA237 to IL-6R inhibited IL-6R-mediated clearance of IL-6, serum IL-6 increased in dams and infants. sa237 23-28 interleukin 6 Homo sapiens 32-36 28504465-6 2017 Because the binding of SA237 to IL-6R inhibited IL-6R-mediated clearance of IL-6, serum IL-6 increased in dams and infants. sa237 23-28 interleukin 6 Homo sapiens 48-52 29651966-13 2018 Additionally, DHC treatment resulted in higher significant levels of IL-6 than did other interleukins and STAT3 up-regulation in U251 cells. dihydrochelerythrine 14-17 interleukin 6 Homo sapiens 69-73 28504465-8 2017 SA237 pharmacological effects contributed to the suppression of plasma cell differentiation and antibody production by inhibiting IL-6 signaling, and T cell-dependent antibody reaction was minimally suppressed in infants, but physiological immunoglobulin class switching and general antibody production against a T cell-dependent antigen were maintained. sa237 0-5 interleukin 6 Homo sapiens 130-134 28444390-10 2017 SMX-NO/flucloxacillin stimulated secretion of TNF-alpha, IL-6, IL-1alpha, and IL-1-beta. Floxacillin 7-21 interleukin 6 Homo sapiens 57-61 26891591-5 2016 Results indicated that some urolithins and ellagic acid were able to reduce the adhesion of THP-1 monocytes to human umbilical vein endothelial cells (HUVECs) and the secretion of a cellular adhesion molecule (sVCAM-1) and pro-inflammatory cytokine (IL-6). Ellagic Acid 43-55 interleukin 6 Homo sapiens 250-254 27272805-6 2016 C-reactive protein (CRP) and interleukin-6 (IL-6) correlated with each other and exhibited positive correlation with age, body-mass index (BMI), leukocyte count, platelet count, kynurenine, kynurenine/tryptophan ratio and urinary neopterin and a negative correlation with vitamin D and retinol. Kynurenine 178-188 interleukin 6 Homo sapiens 29-42 27272805-6 2016 C-reactive protein (CRP) and interleukin-6 (IL-6) correlated with each other and exhibited positive correlation with age, body-mass index (BMI), leukocyte count, platelet count, kynurenine, kynurenine/tryptophan ratio and urinary neopterin and a negative correlation with vitamin D and retinol. Kynurenine 178-188 interleukin 6 Homo sapiens 44-48 27272805-6 2016 C-reactive protein (CRP) and interleukin-6 (IL-6) correlated with each other and exhibited positive correlation with age, body-mass index (BMI), leukocyte count, platelet count, kynurenine, kynurenine/tryptophan ratio and urinary neopterin and a negative correlation with vitamin D and retinol. Kynurenine 190-200 interleukin 6 Homo sapiens 29-42 27272805-6 2016 C-reactive protein (CRP) and interleukin-6 (IL-6) correlated with each other and exhibited positive correlation with age, body-mass index (BMI), leukocyte count, platelet count, kynurenine, kynurenine/tryptophan ratio and urinary neopterin and a negative correlation with vitamin D and retinol. Kynurenine 190-200 interleukin 6 Homo sapiens 44-48 27272805-6 2016 C-reactive protein (CRP) and interleukin-6 (IL-6) correlated with each other and exhibited positive correlation with age, body-mass index (BMI), leukocyte count, platelet count, kynurenine, kynurenine/tryptophan ratio and urinary neopterin and a negative correlation with vitamin D and retinol. Vitamin A 286-293 interleukin 6 Homo sapiens 29-42 28917653-7 2018 Inclusion of a STAT3 inhibitor in the media blunted phosphorylation of the STAT3Y705 and suppressed (P < 0.05) hIL6-mediated bSC proliferation. bsc 128-131 interleukin 6 Homo sapiens 114-118 27272805-6 2016 C-reactive protein (CRP) and interleukin-6 (IL-6) correlated with each other and exhibited positive correlation with age, body-mass index (BMI), leukocyte count, platelet count, kynurenine, kynurenine/tryptophan ratio and urinary neopterin and a negative correlation with vitamin D and retinol. Vitamin A 286-293 interleukin 6 Homo sapiens 44-48 29100297-7 2017 Additionally, the inhibition of IL-6/STAT3 signaling pathway by IL-6 neutralizing antibody or specific inhibitors of JAK2/STAT3 reversed CAF-CM induced EMT and migration of lung cancer cells. caf-cm 137-143 interleukin 6 Homo sapiens 32-36 29100297-7 2017 Additionally, the inhibition of IL-6/STAT3 signaling pathway by IL-6 neutralizing antibody or specific inhibitors of JAK2/STAT3 reversed CAF-CM induced EMT and migration of lung cancer cells. caf-cm 137-143 interleukin 6 Homo sapiens 64-68 28526382-6 2017 RESULTS: MAR and NAR scores for phosphorus; vitamins A, B1, and B6; and niacin were negatively associated with IL-6 (beta = -0.006, -0.004, -0.004, -0.007, -0.004, and -0.005, respectively; P < 0.05). Phosphorus 32-42 interleukin 6 Homo sapiens 111-115 24467668-9 2016 RESULTS: After intravenous (99) Tc-MDP therapy, the frequency of peripheral CD3(+) gammadelta(+) T cells and CD4(+) CD25(+) Foxp3(+) Tregs were significantly elevated, paralleled with decreased serum levels of TNF-alpha and IL-6 and increased level of serum TGF-beta. technetium Tc 99m diphosphonate 32-38 interleukin 6 Homo sapiens 224-228 29796036-4 2018 In this study, we assessed the effect of memantine on the pro-inflammatory cytokines such as IL6, TNFalpha and CRP. Memantine 41-50 interleukin 6 Homo sapiens 93-96 24467668-11 2016 CONCLUSION: (99) Tc-MDP may improve the activity of RA through upregulating the frequency of peripheral gammadelta T cells and CD4(+) CD25(+) Foxp3(+) Tregs as well as affecting the serum cytokine environment by increasing TGF-beta and decreasing TNF-alpha and IL-6. technetium Tc 99m diphosphonate 17-23 interleukin 6 Homo sapiens 261-265 27049850-16 2016 CONCLUSION: Although there is some evidence indicating that the predictors outperform random guessing, the general diagnostic accuracy of EBC acidity and the EBC inflammatory markers IL-6, IL-8, TNF-alpha and MIF is low. NSC638702 158-161 interleukin 6 Homo sapiens 183-187 28559019-0 2017 IL6 is associated with response to dasatinib and cetuximab: Phase II clinical trial with mechanistic correlatives in cetuximab-resistant head and neck cancer. Dasatinib 35-44 interleukin 6 Homo sapiens 0-3 27761846-6 2017 With respect to either ZrO2-added or unmodified CS coating, the CS-30Ce coating elicited higher effects on the macrophages, suppressing the gene expressions of pro-inflammatory (M1) markers (CCR7, IL-6, and TNF-alpha), while upregulating the expressions of anti-inflammatory (M2) markers (CD206, IL-1ra, and IL-10); moreover, it could also increase the expression of osteoinductive molecules (BMP2 and TGF-beta1) by the macrophages. Cesium 64-66 interleukin 6 Homo sapiens 197-201 28842514-10 2017 The poly(I:C)-induced release of inflammatory mediators, including CXCL8, interleukin (IL)-6 and CXCL1, from ASMCs from cough patients was significantly impaired compared with healthy non-cough subjects. poly 4-8 interleukin 6 Homo sapiens 74-92 27981790-4 2017 Compared with the other two groups, the DPN group had higher expression of TLR4, MyD88, phosphorylated IkappaB, TNF-alpha, and IL-6, but significantly lower levels of caveolin-1 and total IkappaB in monocytes. dpn 40-43 interleukin 6 Homo sapiens 127-131 26934431-4 2016 CuONPs treatment caused a significant increase in IL-6 and IL-8 mRNA expression and protein levels in H292 cells in a concentration-dependent manner. cuonps 0-6 interleukin 6 Homo sapiens 50-54 28634844-8 2017 Additional experiments showed that Pyrrolidine dithiocarbamate (PDTC) inhibited IL-6, IL-1beta, and TNF-alpha expression induced by overexpression of TSP-1, accompanying with downregulation of phosphorylated p65 and IkappaBalpha protein levels in response to P. gingivalis LPS. pyrrolidine dithiocarbamic acid 35-62 interleukin 6 Homo sapiens 80-84 26500236-9 2016 After lenvatinib treatment, the number of circulating endothelial and c-Kit(+) cells decreased and the levels of interleukin (IL)-6, IL10, granulocyte-colony stimulating factor, and vascular endothelial growth factor increased (P < 0.05). lenvatinib 6-16 interleukin 6 Homo sapiens 113-131 28393222-12 2017 RIP140 overexpression in TAMs significantly inhibited the alternative activation of macrophages by inhibiting the NF-kappaB/IL-6 axis in TAMs, and suppressed HCC cell growth both in vitro and in vivo. tams 25-29 interleukin 6 Homo sapiens 124-128 26671765-5 2016 The incorporation of UDCA with PSS, PAA and WSG enhanced cell viability per microcapsule (p < 0.05), cellular metabolic profile (p < 0.01) and insulin production (p < 0.01); reduced the inflammatory release TNF-alpha (p < 0.01), INF-gamma (p < 0.01) and interleukin-6 (IL-6) (p < 0.01); and ceased the production of IL-1beta. pss 31-34 interleukin 6 Homo sapiens 269-282 28634844-8 2017 Additional experiments showed that Pyrrolidine dithiocarbamate (PDTC) inhibited IL-6, IL-1beta, and TNF-alpha expression induced by overexpression of TSP-1, accompanying with downregulation of phosphorylated p65 and IkappaBalpha protein levels in response to P. gingivalis LPS. pyrrolidine dithiocarbamic acid 64-68 interleukin 6 Homo sapiens 80-84 26671765-5 2016 The incorporation of UDCA with PSS, PAA and WSG enhanced cell viability per microcapsule (p < 0.05), cellular metabolic profile (p < 0.01) and insulin production (p < 0.01); reduced the inflammatory release TNF-alpha (p < 0.01), INF-gamma (p < 0.01) and interleukin-6 (IL-6) (p < 0.01); and ceased the production of IL-1beta. pss 31-34 interleukin 6 Homo sapiens 284-288 28404919-9 2017 Paeonol inhibited the secretion of IL-6 and TNF-alpha in HaCat and JB6 cells ex vivo. paeonol 0-7 interleukin 6 Homo sapiens 35-39 28961200-0 2017 N-(4-bromophenethyl) Caffeamide Protects Skin from UVB-Induced Inflammation Through MAPK/IL-6/NF-kappaB-Dependent Signaling in Human Skin Fibroblasts and Hairless Mouse Skin. caffeamide 21-31 interleukin 6 Homo sapiens 89-93 28027123-4 2017 RESULTS: Significantly higher concentration of neutrophil elastase, IL-1, IL-6 and C-reactive protein was detected postoperatively in the 30% FiO2 group patients in comparison with the 80% FiO2 group (P<0.05). fio2 142-146 interleukin 6 Homo sapiens 74-78 26518637-0 2016 The effects of omega-3 polyunsaturated fatty acids and genetic variants on methylation levels of the interleukin-6 gene promoter. omega-3 polyunsaturated fatty acids 15-50 interleukin 6 Homo sapiens 101-114 26670944-0 2016 IL-6 Antibody and RGD Peptide Conjugated Poly(amidoamine) Dendrimer for Targeted Drug Delivery of HeLa Cells. amidoamine 46-56 interleukin 6 Homo sapiens 0-4 28631090-9 2017 Pretreatment with topical pseudoceramide protected against UVB-induced upregulation of IL-1beta, IL-6, and TNF-alpha transcription and reduced susceptibility to erythema following UVB. pseudoceramide 26-40 interleukin 6 Homo sapiens 97-101 26899608-4 2016 Serum interleukin-6 (IL-6) levels were significantly lower in the bilateral-DEX group than in the uni-saline group 6 and 24h postoperatively, and were negatively correlated with total DEX dosage 24h postoperatively. Dexmedetomidine 76-79 interleukin 6 Homo sapiens 6-19 26899608-4 2016 Serum interleukin-6 (IL-6) levels were significantly lower in the bilateral-DEX group than in the uni-saline group 6 and 24h postoperatively, and were negatively correlated with total DEX dosage 24h postoperatively. Dexmedetomidine 76-79 interleukin 6 Homo sapiens 21-25 26899608-4 2016 Serum interleukin-6 (IL-6) levels were significantly lower in the bilateral-DEX group than in the uni-saline group 6 and 24h postoperatively, and were negatively correlated with total DEX dosage 24h postoperatively. Dexmedetomidine 184-187 interleukin 6 Homo sapiens 6-19 26899608-4 2016 Serum interleukin-6 (IL-6) levels were significantly lower in the bilateral-DEX group than in the uni-saline group 6 and 24h postoperatively, and were negatively correlated with total DEX dosage 24h postoperatively. Dexmedetomidine 184-187 interleukin 6 Homo sapiens 21-25 26899608-7 2016 The results indicate that perioperative intravenous DEX administration decreases postoperative serum IL-6 levels in patients undergoing bilateral TKA, and has a postoperative analgesic effect in patients undergoing unilateral or bilateral TKA. Dexmedetomidine 52-55 interleukin 6 Homo sapiens 101-105 28089818-9 2017 Enzyme-linked immunosorbent assay results revealed distinct differences in IL-6 and IL-8 secretions by NP cells in response to etoposide in the presence of NCCM. Etoposide 127-136 interleukin 6 Homo sapiens 75-79 28065853-7 2017 Sitagliptin treatment not only inhibited IL-10 (p<0.05) and IFN-gamma (p=0.07) cytokines, but also completely abolish IL-6 expression by PBMCs (p<0.001). Sitagliptin Phosphate 0-11 interleukin 6 Homo sapiens 121-125 28351806-13 2017 In addition, IL-6 was also positively associated with As, Cl and Pe in elderly. pe 65-67 interleukin 6 Homo sapiens 13-17 28293317-1 2017 AIM: The purpose of this study is to see the effect of Dexketoprofen on TNF-alpha, IL-1, and IL-6 serum levels in Chronic Tension-Type Headache (CTTH) patients and its correlation with pain severity. dexketoprofen trometamol 55-68 interleukin 6 Homo sapiens 93-97 26987337-4 2016 In THP1cells, grown in CS-conditioned media, the intracellular interleukins IL-1beta, IL-6, and IL-10 increased by more than tenfold, while less significant increases were found in A549 cells. Cesium 23-25 interleukin 6 Homo sapiens 86-90 28532672-1 2017 In this study, we found that catechins found in green tea (EGCG, EGC, and EC) differentially interfere with the IL-1beta signaling pathway which regulates the expression of pro-inflammatory mediators (IL-6 and IL-8) and Cox-2 in primary human rheumatoid arthritis synovial fibroblasts (RASFs). epigallocatechin gallate 59-63 interleukin 6 Homo sapiens 201-205 26084452-7 2015 In addition, vicenin-2 or scolymoside suppressed the production of tumor necrosis factor-alpha and interleukin 6 and activation of nuclear factor-kappaB and extracellular regulated kinases 1/2 by TGFBIp. vicenin 13-20 interleukin 6 Homo sapiens 99-192 28137586-5 2017 Palmitate exposure (250 muM, 24 h) increased interleukin-6 and tumor necrosis factor-alpha gene expressions and translocation of TLR4 into lipid rafts in 3T3-L1 adipocytes. Palmitates 0-9 interleukin 6 Homo sapiens 45-90 28532672-2 2017 EGCG and EGC inhibited IL-6, IL-8, and MMP-2 production and selectively inhibited Cox-2 expression. epigallocatechin gallate 0-4 interleukin 6 Homo sapiens 23-27 28625979-3 2017 We found that ISX-mediated IL6-induced expression of the tryptophan catabolic enzymes Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase in hepatocellular carcinoma cells, resulting in an ISX-dependent increase in the tryptophan catabolite kynurenine and its receptor aryl hydrocarbon receptor (AHR). Kynurenine 257-267 interleukin 6 Homo sapiens 27-30 27988893-3 2017 Here, we demonstrate a new IPC compound, N-acetylglutaminoyl-S-farnesyl-L-cysteine (SIG-1191), which inhibits UVB-induced inflammation blocking pro-inflammatory cytokine interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) production. N-acetylglutaminoyl-S-farnesyl-l-cysteine 41-82 interleukin 6 Homo sapiens 170-183 27988893-3 2017 Here, we demonstrate a new IPC compound, N-acetylglutaminoyl-S-farnesyl-L-cysteine (SIG-1191), which inhibits UVB-induced inflammation blocking pro-inflammatory cytokine interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) production. N-acetylglutaminoyl-S-farnesyl-l-cysteine 41-82 interleukin 6 Homo sapiens 185-189 26452501-5 2015 PA also increased pro-inflammatory cytokines expression, including tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), and interleukin 1beta (IL-1beta). Palmitates 0-2 interleukin 6 Homo sapiens 108-121 26452501-5 2015 PA also increased pro-inflammatory cytokines expression, including tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), and interleukin 1beta (IL-1beta). Palmitates 0-2 interleukin 6 Homo sapiens 123-127 26410779-5 2015 The analysis of pro-inflammatory cytokines release by ELISA revealed that resveratrol, lipoic acid melatonin and Co-Q10 inhibited the BBB endothelial release of pro-inflammatory cytokines IL-6 and IL-8, reduced (not Co-Q10) CSE-induced up-regulation of Platelet Cell Adhesion Molecule-1 (PECAM-1), Vascular Cell Adhesion Molecule-1 (VCAM-1) & E-selectin and inhibited monocytes-endothelial cell adhesion. lipoic acid melatonin 87-108 interleukin 6 Homo sapiens 188-192 28511912-4 2017 We screened herbal ingredients using primary fibroblasts stimulated with tumor necrosis factor alpha (TNF-alpha) and found the suppressive action of Atractylodin on IL-6 production. atractylodin 149-161 interleukin 6 Homo sapiens 165-169 26531309-9 2015 However, PSA-TMC-ODN and PSA-TMC-ODN-MTX resulted in significant decreases in the inflammatory mediators IL-6 and IL-8 in both cell models. tmc-odn 13-20 interleukin 6 Homo sapiens 105-109 28105083-7 2016 The meta-analysis revealed that the levels of CRP, TNF-alpha, and IL-6 in patients supplemented with Gln were significantly lower than those in control patients, whereas the levels of IL-2 receptor were increased by Gln supplementation. Glutamine 101-104 interleukin 6 Homo sapiens 66-70 28511912-5 2017 Under TNF-alpha stimulation, Atractylodin induced the tri-methylation of histone H3 at lysine residue 9, which impaired the binding between NF-kappaB and the IL-6 promoter on the genomic DNA. atractylodin 29-41 interleukin 6 Homo sapiens 158-162 27421058-6 2016 MTU suppressed the PolyP-mediated vascular barrier permeability, up-regulation of inflammatory biomarkers, adhesion/migration of leucocytes, and activation and/or production of nuclear factor-kappaB, tumour necrosis factor-alpha and interleukin-6. Methylthiouracil 0-3 interleukin 6 Homo sapiens 233-246 26298005-7 2015 Furthermore, MTU suppressed the production of tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6, and the activation of nuclear factor-kappaB (NF-kappaB) and extracellular regulated kinases (ERK) 1/2 by LPS. Methylthiouracil 13-16 interleukin 6 Homo sapiens 90-108 27816506-2 2016 The active constituents of Rosa spp., such as flavonoids, triterpenoids, and phytosterols, could act on different targets in the NF-kappaB signalling pathway, inhibit pro-inflammatory enzymes (e.g. MMPs and COX-2), lower the production of inflammatory cytokines and chemokines (e.g. TNF-alpha, IL-1beta, IL-6, CCL5), and reduce oxidative stress, which in turn suppress inflammatory processes. Phytosterols 77-89 interleukin 6 Homo sapiens 304-308 28099236-9 2017 After 3 days, perfluorohexane treatment significantly (P < .05) increased lung dynamic compliance, and reduced alveolar-arterial oxygen gradient, Acute Physiology and Chronic Health Evaluation II score, percentage of neutrophils, and levels of interleukin-6, interleukin-8, and tumor necrosis factor alpha in bronchoalveolar lavage fluid; there was no significant change in the control group before and after treatment. perflexane 14-29 interleukin 6 Homo sapiens 247-260 27422754-11 2016 TNFalpha- and ET-1-induced IL-6 releases were both reduced by BQ123 but not by BQ788. cyclo(Trp-Asp-Pro-Val-Leu) 62-67 interleukin 6 Homo sapiens 27-31 26014796-2 2015 Here, we report an immunotherapy regimen that combines 1-ethyl-3-(3"-dimethylaminopropyl)-carbodiimide (ECDI)-treated donor lymphoid cell infusion (ECDI-DLI) with thymoglobulin, anti-interleukin-6 receptor antibody and rapamycin to achieve prolonged allogeneic islet graft survival in a nonhuman primate (NHP) model. Ethyldimethylaminopropyl Carbodiimide 104-108 interleukin 6 Homo sapiens 183-196 28559019-8 2017 The IL6 classifier was validated in a separate trial of the same combination, but was unable to segregate survival risk in a clinical trial of cetuximab and bevacizumab suggesting serum IL6 may be specific for the dasatinib-cetuximab combination. Dasatinib 214-223 interleukin 6 Homo sapiens 4-7 25977183-6 2015 Moreover, pretreatment of NHEKs with Z-lig reduced UVB-induced nuclear factor kappa B (NF-kappaB)-dependent inflammatory mediators (IL-6, IL-8 and MCP-1) production at both mRNA and protein level. ligustilide 37-42 interleukin 6 Homo sapiens 132-136 27598116-0 2016 Atractylodin Inhibits Interleukin-6 by Blocking NPM-ALK Activation and MAPKs in HMC-1. atractylodin 0-12 interleukin 6 Homo sapiens 22-35 28559019-8 2017 The IL6 classifier was validated in a separate trial of the same combination, but was unable to segregate survival risk in a clinical trial of cetuximab and bevacizumab suggesting serum IL6 may be specific for the dasatinib-cetuximab combination. Dasatinib 214-223 interleukin 6 Homo sapiens 186-189 27598116-5 2016 IL-6 levels in the HMC-1 stimulated by phorbol-12-myristate-13-acetate and A23187 were apparently decreased by the treatment of atractylodin. atractylodin 128-140 interleukin 6 Homo sapiens 0-4 26330753-5 2015 This study was carried out to assess how dexmedetomidine modulates histamine-induced Ca(2+) signaling and regulates the expression of pro-inflammatory cytokine genes encoding interleukin (IL)-6 and -8. Dexmedetomidine 41-56 interleukin 6 Homo sapiens 175-200 26330753-10 2015 Collectively, these findings suggest that dexmedetomidine modulates histamine-induced Ca(2+) signaling and IL-6 expression and will be useful for understanding the antagonistic properties of dexmedetomidine on histamine-induced signaling beyond its sedative effect. Dexmedetomidine 42-57 interleukin 6 Homo sapiens 107-111 28559019-10 2017 CONCLUSION: Clinical benefit and overall survival from the dasatinib-cetuximab combination were improved among patients with low serum IL6. Dasatinib 59-68 interleukin 6 Homo sapiens 135-138 26330753-10 2015 Collectively, these findings suggest that dexmedetomidine modulates histamine-induced Ca(2+) signaling and IL-6 expression and will be useful for understanding the antagonistic properties of dexmedetomidine on histamine-induced signaling beyond its sedative effect. Dexmedetomidine 191-206 interleukin 6 Homo sapiens 107-111 28559019-11 2017 Preclinical studies support IL6 as a modifier of dasatinib-cetuximab response. Dasatinib 49-58 interleukin 6 Homo sapiens 28-31 28559019-12 2017 In the setting of clinical cetuximab resistance, serum IL6 is a candidate predictive marker specific for combined dasatinib-cetuximab. Dasatinib 114-123 interleukin 6 Homo sapiens 55-58 28512447-6 2017 Given exercise induces IL-6 myokine signaling, and exercise has been shown to elicit numerous beneficial effects for the treatment of DPN, a causal link has been suggested. dpn 134-137 interleukin 6 Homo sapiens 23-27 26033364-9 2015 In HepG2 cells, both IL-6 and TNF-alpha treatments produced significant miR-101 overexpression; however, in THP-1-derived macrophages, only IL-6 treatment produced significant miR-101 overexpression. mir-101 72-79 interleukin 6 Homo sapiens 21-25 26033364-9 2015 In HepG2 cells, both IL-6 and TNF-alpha treatments produced significant miR-101 overexpression; however, in THP-1-derived macrophages, only IL-6 treatment produced significant miR-101 overexpression. mir-101 176-183 interleukin 6 Homo sapiens 21-25 26033364-9 2015 In HepG2 cells, both IL-6 and TNF-alpha treatments produced significant miR-101 overexpression; however, in THP-1-derived macrophages, only IL-6 treatment produced significant miR-101 overexpression. mir-101 176-183 interleukin 6 Homo sapiens 140-144 27093475-7 2016 Moreover, CS extract induced cellular senescence in cultured human airway epithelial cells, represented by induced senescence-associated beta-galactosidase activity, inhibited cell proliferation, increased p21 expression, and increased release of high-mobility group box 1 and IL-6. Cesium 10-12 interleukin 6 Homo sapiens 277-281 27484716-7 2016 The results demonstrated that celastrol significantly attenuated the expression of IL-6, IL-8, cyclooxygenase (COX)-2 and intercellular adhesion molecule-1 (ICAM-1), and inhibited IL-1beta-induced increases in the expression of IL-6, IL-8, ICAM-1 and COX-2. celastrol 30-39 interleukin 6 Homo sapiens 83-87 27484716-7 2016 The results demonstrated that celastrol significantly attenuated the expression of IL-6, IL-8, cyclooxygenase (COX)-2 and intercellular adhesion molecule-1 (ICAM-1), and inhibited IL-1beta-induced increases in the expression of IL-6, IL-8, ICAM-1 and COX-2. celastrol 30-39 interleukin 6 Homo sapiens 228-232 28512447-9 2017 Collectively, studies suggest that IL-6, when administered in a low-dose pulsatile strategy to mimic the body"s natural response to exercise, may prove to be an effective treatment for the protection and/or restoration of peripheral nerve function in DPN. dpn 251-254 interleukin 6 Homo sapiens 35-39 25822580-4 2015 Co-stimulation with IFN-gamma and the TLR3 ligand poly (I:C) synergistically increased the expression of IFN-beta, IL-6, IL-8, and human beta-defensin-2 in NHEKs compared with poly (I:C) or IFN-gamma alone. poly 50-54 interleukin 6 Homo sapiens 115-119 28512447-10 2017 This review highlights the studies supporting this assertion and provides rationale for continued investigation of IL-6 for the treatment of DPN. dpn 141-144 interleukin 6 Homo sapiens 115-119 28288823-13 2017 Upregulation of cadmium-induced IL-6 was inhibited by U0126 and SC-514, but not SB203580. SC 514 64-70 interleukin 6 Homo sapiens 32-36 27434097-4 2016 When we transfected hepatocytes with an enhanced green fluorescent protein (EGFP)-tagged MHBs expressing plasmid, the results showed that expression of MHBs cause an upregulation of IL-6 at the message RNA and protein levels through activating the p38 mitogen-activated protein kinase (p38 MAPK) and nuclear factor-kappa B (NF-kappaB) pathways. mhbs 89-93 interleukin 6 Homo sapiens 182-186 27434097-4 2016 When we transfected hepatocytes with an enhanced green fluorescent protein (EGFP)-tagged MHBs expressing plasmid, the results showed that expression of MHBs cause an upregulation of IL-6 at the message RNA and protein levels through activating the p38 mitogen-activated protein kinase (p38 MAPK) and nuclear factor-kappa B (NF-kappaB) pathways. mhbs 152-156 interleukin 6 Homo sapiens 182-186 26231702-9 2015 RESULTS: The cell culture studies revealed that esomeprazole controls inflammation by suppressing the expression of pro-inflammatory molecules including vascular cell adhesion molecule-1, inducible nitric oxide synthase, tumor necrosis factor-alpha (TNF-alpha) and interleukins (IL-1beta and IL-6). Esomeprazole 48-60 interleukin 6 Homo sapiens 292-296 28441756-6 2017 Paradoxically, the release of inflammatory cytokine interleukin-6 (IL-6) was decreased, which indicated the anti-inflammatory effects of ZnO NPs when BSA was present. Zinc Oxide 137-140 interleukin 6 Homo sapiens 52-65 26303694-5 2015 Postoperative CRP and IL-6 levels were slightly higher in HALS group, but the difference was not statistically significant (P>0.05). Fluoxymesterone 58-62 interleukin 6 Homo sapiens 22-26 26114947-4 2015 Knockdown or genetic ablation of TRIM30alpha augmented the type I IFNs and interleukin-6 response to intracellular DNA and DNA viruses. trim30alpha 33-44 interleukin 6 Homo sapiens 75-88 27038916-6 2016 The amounts of proinflammatory cytokines produced by macrophages, such as interleukin 1 beta, interleukin 6, and tumor necrosis factor alpha, were reduced significantly for the quercetin-loaded silica nanoparticles. Silicon Dioxide 194-200 interleukin 6 Homo sapiens 94-107 27227459-4 2016 The oral administration of MG (7 mg/kg) attenuates arthritis induced by zymosan, affecting edema formation, leukocyte migration, and the production of inflammatory mediators (IL-1beta, IL-6, TNF-alpha, CXCL-1, LTB4, and PGE2). methyl gallate 27-29 interleukin 6 Homo sapiens 185-189 28441756-6 2017 Paradoxically, the release of inflammatory cytokine interleukin-6 (IL-6) was decreased, which indicated the anti-inflammatory effects of ZnO NPs when BSA was present. Zinc Oxide 137-140 interleukin 6 Homo sapiens 67-71 28262826-9 2017 DNA (cytosine-5-)-methyltransferase 3 alpha (Dnmt3a) overexpression and anacardic acid (histone acetyltransferase inhibitor) treatment increased DNA methylation and decreased histone acetylation in the IL-6 promoter, and IL-6 over-expression in OA SF was suppressed. anacardic acid 72-86 interleukin 6 Homo sapiens 202-206 27106081-7 2016 The bromodomain inhibitors effectively decreased etoposide-induced release of IL-6 and IL-8. Etoposide 49-58 interleukin 6 Homo sapiens 78-82 25975581-4 2015 The anti-inflammatory effect of isoacteoside was investigated in HMC-1 cells by studying the following markers: phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-induced interleukin (IL)-1beta, IL-6, IL-8, and tumor necrosis factor alpha (TNF-alpha) secretion and mRNA expression by ELISA and RT-PCR, respectively. isoacteoside 32-44 interleukin 6 Homo sapiens 213-217 25975581-6 2015 Isoacteoside significantly suppressed the production and mRNA expression of proinflammatory cytokines including IL-1beta, IL-6, IL-8 and TNF-alpha in PMACI-stimulated HMC-1 cells without cytotoxicity. isoacteoside 0-12 interleukin 6 Homo sapiens 122-126 28262826-9 2017 DNA (cytosine-5-)-methyltransferase 3 alpha (Dnmt3a) overexpression and anacardic acid (histone acetyltransferase inhibitor) treatment increased DNA methylation and decreased histone acetylation in the IL-6 promoter, and IL-6 over-expression in OA SF was suppressed. anacardic acid 72-86 interleukin 6 Homo sapiens 221-225 27859014-7 2017 In the PNG cohort, higher PspA-specific IL-5 and IL-6 CBMC responses were associated independently and significantly with increased risk of earlier pneumococcal colonization, while a significant protective effect was found for higher PspA-IL-10 CBMC responses. cbmc 54-58 interleukin 6 Homo sapiens 49-53 25824337-6 2015 In the 4-NQO-induced esophageal tumor animal model, increased IL6 and MDSC recruitment were linked with invasive esophageal tumors. 4-Nitroquinoline-1-oxide 7-12 interleukin 6 Homo sapiens 62-65 26600084-9 2016 CS caused an increase in IL-6 production by epithelial cells that was dependent on HER2-mediated extracellular signal-regulated kinases (Erk) activation. Cesium 0-2 interleukin 6 Homo sapiens 25-29 26600084-10 2016 Finally, blockade of IL-6 attenuated CS-induced epithelial permeability. Cesium 37-39 interleukin 6 Homo sapiens 21-25 27940088-4 2017 For example, in separate reports, vitamin A was shown to decrease Th17 T-cell activity by downregulating IL-6, and to promote B cell production of IgA by upregulating IL-6. Vitamin A 34-43 interleukin 6 Homo sapiens 105-109 27170049-10 2016 Orbital fibroblasts expressed HRH1 and loratadine and SC-514 both blocked histamine-induced IL-6, IL-8 and CCL2 production by orbital fibroblasts. SC 514 54-60 interleukin 6 Homo sapiens 92-96 26641976-17 2016 Melatonin was a strong inducer of TNF-alpha in RAW cells, whereas 3-OH kynurenine at 25, 50 and 100 microg/mL inhibited IL-6 in RAW cells. 3-oh kynurenine 66-81 interleukin 6 Homo sapiens 120-124 25985190-3 2015 In A549 lung epithelial cells in vitro we show that inhibition of basal PP2A activity by okadaic acid (OA) releases restraint on MAPKs and thereby increases MAPK-mediated pro-asthmatic cytokines, including IL-6 and IL-8. Okadaic Acid 89-101 interleukin 6 Homo sapiens 206-210 25985190-3 2015 In A549 lung epithelial cells in vitro we show that inhibition of basal PP2A activity by okadaic acid (OA) releases restraint on MAPKs and thereby increases MAPK-mediated pro-asthmatic cytokines, including IL-6 and IL-8. Okadaic Acid 103-105 interleukin 6 Homo sapiens 206-210 27940088-4 2017 For example, in separate reports, vitamin A was shown to decrease Th17 T-cell activity by downregulating IL-6, and to promote B cell production of IgA by upregulating IL-6. Vitamin A 34-43 interleukin 6 Homo sapiens 167-171 26191223-6 2015 PE significantly inhibited poly (I:C)-induced expression of crucial psoriatic cytokines, such as IL-6, IL-8, CCL20 and TNF-alpha, via down-regulation of NF-kappaB signaling pathway in human keratinocytes. pe 0-2 interleukin 6 Homo sapiens 97-101 27815224-10 2017 Brain glutamine had a significant positive correlation with blood ammonia, IL-6, TNF-alpha and MD of various brain regions. Glutamine 6-15 interleukin 6 Homo sapiens 75-79 25898005-8 2015 Second, we found that CDG selectively activated pinocytosis-efficient-DCs, leading to T(H) polarizing cytokines IL-12p70, IFNgamma, IL-5, IL-13, IL-23, and IL-6 production in vivo. bis(3',5')-cyclic diguanylic acid 22-25 interleukin 6 Homo sapiens 156-160 26996478-2 2016 This study was to determine the effect of inhaled corticosteroid (ICS) treatment on IL-4 and IL-6 in the EBC of asthmatic patients. NSC638702 105-108 interleukin 6 Homo sapiens 93-97 26704762-1 2017 OBJECTIVE: The objective was to investigate the benefits of supplementing enteral feeding with omega-3 fatty acids in children with mild to moderate sepsis and its effects on acute-phase reactants and interleukin 6 (IL-6) level. Fatty Acids, Omega-3 95-114 interleukin 6 Homo sapiens 201-214 26705299-8 2016 Biomarkers of systemic inflammation (IL-6, myeloperoxidase and elastase) were also lower in the CS group. Cesium 96-98 interleukin 6 Homo sapiens 37-71 28179289-8 2017 RESULTS: IL-6 and TNF-alpha induced STAT3 and STAT1 interactions, however the interactions were abolished by salinomycin challenge. salinomycin 109-120 interleukin 6 Homo sapiens 9-13 26998101-4 2016 The exact mechanism of action is not yet clear, however, we hypothesize that thalidomide may function through decreasing the secretion of interleukin-6 and affecting the growth of plasma cells. Thalidomide 77-88 interleukin 6 Homo sapiens 138-151 25937780-9 2015 Higher mRNA and supernate secretion levels of IL-1beta, IL-6 and IL-8 were detected in SPC-A1 after being cocultured with TAMs. tams 122-126 interleukin 6 Homo sapiens 56-60 25937780-13 2015 CONCLUSIONS: These findings demonstrated that TAMs may enhance IL-1beta, IL-6 and IL-8 expressions via TLRs signaling pathway. tams 46-50 interleukin 6 Homo sapiens 73-77 25515776-6 2015 Poly(dA:dT) induced the expression of pro-inflammatory cytokine genes including IFN-beta, TNF-alpha, IL-6 and IL-8 as well, whereas the pro-inflammatory cytokine production was suppressed by RIG-I siRNA, but not by AIM2 siRNA. poly 0-4 interleukin 6 Homo sapiens 101-105 25515776-6 2015 Poly(dA:dT) induced the expression of pro-inflammatory cytokine genes including IFN-beta, TNF-alpha, IL-6 and IL-8 as well, whereas the pro-inflammatory cytokine production was suppressed by RIG-I siRNA, but not by AIM2 siRNA. Thymidine 8-10 interleukin 6 Homo sapiens 101-105 27236883-12 2016 CONCLUSION: Dexmedetomidine combied electrical stimulation could effectively prevent the occurrence of postoperative cognition, and reduce levels of NSA, S-100beta, IL-1beta, IL-6 and TNF-alpha. Dexmedetomidine 12-27 interleukin 6 Homo sapiens 175-179 27776235-6 2017 Furthermore, the results indicated that EGCG inhibited the production of reactive oxygen species (ROS), tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6) in MC-LR-stimulated HUVECs. epigallocatechin gallate 40-44 interleukin 6 Homo sapiens 149-162 26918785-4 2016 We show that CDDO-Me treatment inhibits expression of IL-10 and VEGF in stimulated human M2 macrophages and TAMs but increases expression of TNF-alpha and IL-6. bardoxolone methyl 13-20 interleukin 6 Homo sapiens 155-159 26909479-1 2016 OBJECTIVE: The objective of the present study was to investigate the effect of vitamin A supplementation on serum Th17 (IL-6, IL-17, IFNgamma) and Treg (TGF-beta, IL-10) related cytokines in obese and non-obese women. Vitamin A 79-88 interleukin 6 Homo sapiens 120-124 25647410-10 2015 The inhibition of autophagy led to a further increase in the PA-induced expression of monocyte chemoattractant protein-1 (MCP-1) and interleukin-6 (IL-6). Palmitates 61-63 interleukin 6 Homo sapiens 133-146 25647410-10 2015 The inhibition of autophagy led to a further increase in the PA-induced expression of monocyte chemoattractant protein-1 (MCP-1) and interleukin-6 (IL-6). Palmitates 61-63 interleukin 6 Homo sapiens 148-152 26064392-8 2015 Compared to control group, Dexmedetomidine significantly inhibited the increase of post-operative IL-6 and TNF-alpha levels (P < 0.05). Dexmedetomidine 27-42 interleukin 6 Homo sapiens 98-102 27776235-6 2017 Furthermore, the results indicated that EGCG inhibited the production of reactive oxygen species (ROS), tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6) in MC-LR-stimulated HUVECs. epigallocatechin gallate 40-44 interleukin 6 Homo sapiens 164-168 27956244-5 2017 Nevertheless DTX-1 was more potent than OA in increasing TNF-alpha and IL-6 as well as their dependent chemokines KC, MCP-1, LIX, MIP-1 alpha, MIP-1 beta and MIP-2. dinophysistoxin 1 13-18 interleukin 6 Homo sapiens 71-75 25455350-0 2015 Increased levels of IL-6 in the cerebrospinal fluid of patients with chronic schizophrenia--significance for activation of the kynurenine pathway. Kynurenine 127-137 interleukin 6 Homo sapiens 20-24 26878794-7 2016 PCB 126 exposure increased the expression of vascular inflammatory mediators, including interleukin (IL)-6, C-reactive protein, intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and IL-1alpha/beta, which were prevented by pretreatment with EGCG. epigallocatechin gallate 259-263 interleukin 6 Homo sapiens 88-106 28241693-7 2017 After pretreated with various concentrations of Gas6 antibody, silica induced higher expressions of inflammatory cytokines (TNF-alpha, IL-1beta, IL-6) in dose-dependent manners at two time points. Silicon Dioxide 63-69 interleukin 6 Homo sapiens 145-149 26553025-10 2016 However, a trend toward decreased IL-6, IL-8, and IFN-gamma levels, and favorable clinical outcomes were present in the macrolide group. Macrolides 120-129 interleukin 6 Homo sapiens 34-38 25835116-9 2015 Furthermore, patients on both rifaximin and norfloxacin therapies showed a statistically significant decrease in TNF-alpha and IL-6 serum levels compared with their baseline levels (p=0.000 and p=0.000, respectively). Rifaximin 30-39 interleukin 6 Homo sapiens 127-131 27902467-6 2017 Endogenous IL-6 inhibition in somatotroph MtT/S shRNA stable clones results in decreased SA-beta-gal activity and p16INK4a but increased pRb, proliferation and invasion. 2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid 89-100 interleukin 6 Homo sapiens 11-15 25849726-6 2015 RESULTS: Non-responders patients treated with macrolide containing regimens showed significantly lower levels of IL-6 and TNF-alpha in bronchoalveolar lavage fluid and lower IL-8 and IL-10 in blood than those patients treated with non-macrolide regimens. Macrolides 46-55 interleukin 6 Homo sapiens 113-117 26552040-7 2016 In DM group, C-reactive protein (CRP) decreased significantly at 3months postoperatively and inflammatory markers interleukin-6 (IL-6) and TRACP 5a improved at 6months postoperatively; in non-DM group, serum TRACP 5a decreased obviously at 12months postoperatively without significant changes in CRP and IL-6. dm 3-5 interleukin 6 Homo sapiens 304-308 28054602-0 2017 Identification of Guanosine 5"-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway. Guanosine Diphosphate 18-42 interleukin 6 Homo sapiens 139-152 23982695-7 2016 The AUC of serum IL-6 was lowered significantly (P = 0.03, n = 10) with BRB consumption (34.3 +- 7.6 pg mL-1 h-1 compared with 42.4 +- 17.9 pg mL-1 h-1 for consumption of the HFHC meal alone). 4-Bromobenzyl alcohol 72-75 interleukin 6 Homo sapiens 17-21 26909786-7 2016 DEX+TIVA use was associated with a significant reduction in IL-1, IL-6, TNF-alpha, and INF-gamma (P<0.0001) levels compared with TIVA (two-way ANOVA). dex+tiva 0-8 interleukin 6 Homo sapiens 66-70 25769330-10 2015 The levels of TNF-alpha, NSE, and IL-6 in the dexmedetomidine group were significantly reduced compared with those in the control group (P<0.05). Dexmedetomidine 46-61 interleukin 6 Homo sapiens 34-38 29055943-8 2017 Furthermore activation of Akt showed upregulated expression of the IL-6 protein whereas Akt inhibitor, LY294002 or Akt siRNA significantly inhibited SIRT1-regulated IL-6 expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 103-111 interleukin 6 Homo sapiens 165-169 25351958-4 2015 Treatment of macrophages with bosutinib or dasatinib elevates the production of IL-10 while suppressing the production of IL-6, IL-12p40 and tumour necrosis factor alpha (TNFalpha) in response to Toll-like receptor (TLR) stimulation. Dasatinib 43-52 interleukin 6 Homo sapiens 122-126 26909786-7 2016 DEX+TIVA use was associated with a significant reduction in IL-1, IL-6, TNF-alpha, and INF-gamma (P<0.0001) levels compared with TIVA (two-way ANOVA). tiva 4-8 interleukin 6 Homo sapiens 66-70 26909786-10 2016 DEX as an adjuvant in anesthesia reduced circulating IL-1, IL-6, TNF-alpha, and INF-gamma levels after mini-CPB. Dexmedetomidine 0-3 interleukin 6 Homo sapiens 59-63 26531764-8 2016 CONCLUSION: In our study, naive patients starting tenofovir/emtricitabine or abacavir/lamivudine plus efavirenz showed after 48 weeks a significant and comparable decrease in serum concentrations of IL-6, TNF-alpha, ICAM-1, VCAM-1, Eselectin and P-selectin, while the mean level of hs-CRP did not change significantly in any group. Tenofovir 50-59 interleukin 6 Homo sapiens 199-203 25345551-5 2015 RESULTS: Although flow cytometry and IHC revealed HBCs to be M2 (anti-inflammatory) macrophages, LPS and polyinosinic: polycytidylic acid [poly (I:C)] treatments markedly enhanced IL-6 secretion by HBCs, and expression of TLR-2, TLR-3, TLR-4, CD14, and MD-2 was the highest in HBCs. polyinosinic 105-117 interleukin 6 Homo sapiens 180-184 28664839-9 2017 Mean change in IL-6 was -29% (from 2.53 to 2.02 pg/mL) in the paricalcitol group and 23% (from 2.07 to 2.54 pg/mL) in the placebo group (p < 0.001). paricalcitol 62-74 interleukin 6 Homo sapiens 15-19 25345551-5 2015 RESULTS: Although flow cytometry and IHC revealed HBCs to be M2 (anti-inflammatory) macrophages, LPS and polyinosinic: polycytidylic acid [poly (I:C)] treatments markedly enhanced IL-6 secretion by HBCs, and expression of TLR-2, TLR-3, TLR-4, CD14, and MD-2 was the highest in HBCs. Poly C 119-137 interleukin 6 Homo sapiens 180-184 25596480-2 2015 Cytotoxicity and inflammatory cytokines (IL-1beta, TNF-alpha and IL-6) expressions measured showed that they were induced by both silica particles in positive dose-dependent manners. Silicon Dioxide 130-136 interleukin 6 Homo sapiens 65-69 29889401-3 2016 RESULTS: Based on the analysis of hemodynamic parameters, evaluation of pain using a numeric rating scale pain concluded that selective agonist of o-2 adrenergic dexmedetomidine in combination with nefopam provides effective postoperative pain relief in patients who underwent bariatric surgery, and is not a factor for suppression of postoperative inflammatory response Unlike the effects of ketorolac tromethamine, do not always provide a sufficient level of analgesia and reduce the rate of growth in the level of IL-6. Dexmedetomidine 162-177 interleukin 6 Homo sapiens 517-521 26580447-7 2015 Dietary TB supplementation inhibited the increase of interleukin-1beta (in the jejunum and ileum), interleukin-6 (in the duodenum and jejunum), and prostaglandin E2 (in the duodenum) of LPS-challenged broilers. tributyrin 8-10 interleukin 6 Homo sapiens 99-112 25596480-4 2015 When pretreated with anti-human IL-1beta, not only the high levels of IL-1beta but also elevated TNF-alpha and IL-6 induced by both silica particles were remarkably blocked, especially Si1mum particle. Silicon Dioxide 132-138 interleukin 6 Homo sapiens 111-115 28664839-11 2017 CONCLUSION: In kidney transplant recipients, the addition of 2 microg/day paricalcitol to RAS inhibition lowers IL-6 and TGF-beta concentrations, which may be beneficial for reducing graft inflammation and fibrosis. paricalcitol 74-86 interleukin 6 Homo sapiens 112-116 27717915-8 2016 CpG/DcMNP treatment leads to an increase in the release of IL-6 in MDA-MB231 and SKBR3 cells, whereas release of IL-10 and TNF-alpha did not change significantly. dcmnp 4-9 interleukin 6 Homo sapiens 59-63 25330767-0 2015 Verapamil modulates interleukin-5 and interleukin-6 secretion in organotypic human sinonasal polyp explants. Verapamil 0-9 interleukin 6 Homo sapiens 38-51 25330767-8 2015 The percent of SEB-stimulated IL-6 secretion (217.53% +- 89.51%) was also significantly reduced following exposure to verapamil (148.82% +- 79.15%, p < 0.05) but not dexamethasone (148.86% +- 145.24%). Verapamil 118-127 interleukin 6 Homo sapiens 30-34 26164850-5 2015 Uric acid and interleukin (IL)-6 levels decreased significantly in hyperuricemic patients after 2 months of febuxostat treatment. Febuxostat 108-118 interleukin 6 Homo sapiens 14-32 27566200-0 2016 Ginsenoside 20(S)-Rh2 exerts anti-cancer activity through targeting IL-6-induced JAK2/STAT3 pathway in human colorectal cancer cells. ginsenoside 20 0-14 interleukin 6 Homo sapiens 68-72 25715004-5 2015 RESULTS: Latanoprost stimulated the release of IL-6, IL-8, and MCP-1 from HTFs in a concentration-dependent and time-dependent manner, whereas timolol maleate and pilocarpine had no such effects. htfs 74-78 interleukin 6 Homo sapiens 47-51 26885050-6 2015 In this study, we showed Dex inhibited the increase in cTnI and CK-MB, attenuated the production of pro-inflammatory cytokines TNF-alpha, IL-6 and IL-8, and promoted anti-inflammatory cytokine IL-10 production. Dexmedetomidine 25-28 interleukin 6 Homo sapiens 138-142 26267111-9 2014 Protein-introduced Zraf322 inhibited the production of IL-6 and PGE2 and inhibited cell proliferation in MH7A cells. zraf322 19-26 interleukin 6 Homo sapiens 55-59 28078047-5 2016 Synthesis of IL-6, MCP-1 and hyaluronan in unstimulated and stimulated with interleukin-1 (100 pg/ml) HPMC was inhibited in the presence of DHMEQ and the effect was proportional to the dose of the drug. dehydroxymethylepoxyquinomicin 140-145 interleukin 6 Homo sapiens 13-17 25201328-7 2014 RESULTS: IL-1Ra, IL-6, IL-8, IL-10, IL-15, and MCP-1 were significantly elevated in the PTAA group. ptaa 88-92 interleukin 6 Homo sapiens 17-21 25491674-13 2015 CONCLUSION: MMC treatment leads to elevated urinary CK levels with significantly higher MCP-1 and IL-6 levels in C-HT-treated patients. Mitomycin 12-15 interleukin 6 Homo sapiens 98-102 28078047-6 2016 DHMEQ (10 microg/ml) reduced in unstimulated HPMC synthesis of IL-6 (-55%), MCP-1 (-58%) and hyaluronan (-41%). dehydroxymethylepoxyquinomicin 0-5 interleukin 6 Homo sapiens 63-67 25289074-7 2014 The serum level of PGRN in the pSS patients was shown to correlate with that of IL-6 in the pre-treatment and post-treatment stages. pss 31-34 interleukin 6 Homo sapiens 80-84 27539101-5 2016 Many significant associations were found between the increase of IL-6, resp. SAA and the amounts of n-6 polyunsaturated fatty acids (namely linoleic, dihomo-gamma-linolenic, docosatetraenoic and docosapentaenoic acid), resp. saturated fatty acids (pentadecanoic, stearic, nonadecanoic) in erythrocyte membranes. docosatetraenoic 174-190 interleukin 6 Homo sapiens 65-69 26049028-8 2015 We show for the first time that PF-mediated reduction of IL-1beta and IL-6 was due in part to the reduced expression and activation of the ATP sensor P2X7R on pSS PBMCs, indicating that PF might be useful for the management of pSS via down-regulating P2X7R expression. pss 159-162 interleukin 6 Homo sapiens 70-74 27579474-10 2016 Gln treatment of PBMCs overcame PfHz-induced suppression of HSP70 transcripts/protein, reduced NF-kappaB activation, and suppressed over-expression of IL-1beta, IL-6 and TNF-alpha. Glutamine 0-3 interleukin 6 Homo sapiens 161-165 25970160-1 2015 PURPOSE: It is known that over expression of IL6 in prostate cancer cells confer enzalutamide resistance and that this may occur through constitutive Stat3 activation. enzalutamide 81-93 interleukin 6 Homo sapiens 45-48 25970160-10 2015 Knock down of Stat3 abrogated enzalutamide resistance resulting in reduced recruitment of AR to the PSA promoter in prostate cancer cells expressing IL6. enzalutamide 30-42 interleukin 6 Homo sapiens 149-152 25174313-6 2014 Treatment with high doses of ambroxol appeared to reduce serum tumor necrosis factor-alpha level (WMD -7.92 microg/L; 95% CI, -10.94 to -4.9) and interleukin-6 level (WMD = -20.65 microg/L, 95% CI: -24.74 to -16.55) and to increase serum superoxide dismutase level (WMD = 19.07 NU/mL, 95% CI: 6.16-31.97). Ambroxol 29-37 interleukin 6 Homo sapiens 146-159 25970160-12 2015 CONCLUSIONS: This study demonstrated the IL6-Stat3-AR axis in prostate cancer is one of the crucial mechanisms of enzalutamide resistance. enzalutamide 114-126 interleukin 6 Homo sapiens 41-44 27579474-10 2016 Gln treatment of PBMCs overcame PfHz-induced suppression of HSP70 transcripts/protein, reduced NF-kappaB activation, and suppressed over-expression of IL-1beta, IL-6 and TNF-alpha. pfhz 32-36 interleukin 6 Homo sapiens 161-165 25970160-13 2015 Niclosamide has the potential to target the IL6-Stat3-AR pathway to overcome enzalutamide resistance and inhibit migration and invasion in advanced prostate cancer. enzalutamide 77-89 interleukin 6 Homo sapiens 44-47 25086397-6 2014 The treatment of primary splenocytes with 1-GOs and 6-GOs in the presence of concanavalin A, anti-CD3 antibody and lipopolysaccharide, produced significant dose-dependent decreases of cell proliferation and IL-6 levels, revealing weak inflammatory properties of GOs which are favourable for hyperthermia cancer therapy. 1-gos 42-47 interleukin 6 Homo sapiens 207-211 27650973-5 2016 Furthermore, the production of IL-6 and phosphorylation of p38 in SSc fibroblasts was enhanced by adrenergic receptor (AR)beta agonist, isoproterenol, but not ARalpha agonist, oxymetazoline. Isoproterenol 136-149 interleukin 6 Homo sapiens 31-35 24844442-1 2014 Amorphous silica nanoparticles (SiNPs) have previously been shown to induce marked cytokine (interleukin-6; IL-6 and interleukin-8; CXCL8/IL-8) responses independently of particle uptake in human bronchial epithelial BEAS-2B cells. Silicon Dioxide 10-16 interleukin 6 Homo sapiens 93-106 24844442-1 2014 Amorphous silica nanoparticles (SiNPs) have previously been shown to induce marked cytokine (interleukin-6; IL-6 and interleukin-8; CXCL8/IL-8) responses independently of particle uptake in human bronchial epithelial BEAS-2B cells. Silicon Dioxide 10-16 interleukin 6 Homo sapiens 108-112 25937253-12 2015 RESULTS: Piscroside C significantly reduced the neutrophil influx, reactive oxygen species production, IL-6, TNF-alpha, and elastase activity in bronchoalveolar lavage fluid in COPD animals. piscroside C 9-21 interleukin 6 Homo sapiens 103-107 25937253-14 2015 Consistent with the results of in vivo experiment, piscroside C significantly inhibited the expression of inflammatory cytokines (IL-6, IL-8 and IL-1beta) by inhibiting NF-kappaB activation, as resulting decrease in the phosphorylation of IKKbeta, IkappaBalpha and TAK1 in TNF-alpha-stimulated H292 cells. piscroside C 51-63 interleukin 6 Homo sapiens 130-134 26196332-7 2015 In conclusion, perioperative adjunctive use of dexmedetomidine substantially decreases serum IL-6, IL-8 and TNF-alpha levels. Dexmedetomidine 47-62 interleukin 6 Homo sapiens 93-97 27706719-8 2016 Moreover, elevated IL6 expression was associated with high PSA recurrence rate in Oncomine data. oncomine 82-90 interleukin 6 Homo sapiens 19-22 25650123-10 2015 The IL-6 and IL-8 concentration was below the detection limit in all EBC samples. NSC638702 69-72 interleukin 6 Homo sapiens 4-8 25843793-8 2015 The further study indicated that NAD(P)H oxidase inhibitor DPI and NF-kappaB inhibitor PDTC reduced NE-induced mRNA and protein expression of IL-6 in U937 macrophages. Phosphorus 36-38 interleukin 6 Homo sapiens 142-146 25064453-0 2014 Amphotericin B down-regulates Aggregatibacter actinomycetemcomitans-induced production of IL-8 and IL-6 in human gingival epithelial cells. Amphotericin B 0-14 interleukin 6 Homo sapiens 99-103 25064453-5 2014 Amphotericin B and the p38 MAP kinase inhibitor down-regulated the A. actinomycetemcomitans-induced increase in the expression of IL-8 and IL-6 at the mRNA. Amphotericin B 0-14 interleukin 6 Homo sapiens 139-143 24859059-9 2014 Thalidomide analogs 1 and 2 demonstrated more potent activity to suppress expression levels of IL-6, IL-8, TNF-alpha, VEGF165, and MMP-2 than thalidomide. Thalidomide 0-11 interleukin 6 Homo sapiens 95-99 27296843-3 2016 SMG was either incorporated within the alginate microbeads or used as a secondary coat on poly-l-lysine (PLL)-containing microcapsules, resulting in reduction of the inflammatory cytokines (IL-1beta, TNF, IL-6, IL-8, MIP-1alpha). N-SUCCINYL METHIONINE 0-3 interleukin 6 Homo sapiens 205-209 24854955-9 2014 The mRNA for interleukin-6 and tumor necrosis factor-alpha was higher with AEA but lower with DHA and docosahexaenoyl ethanolamide (DHEA), supporting previous findings that the EC AEA supports activation of the COX system. anandamide 75-78 interleukin 6 Homo sapiens 13-58 24854955-9 2014 The mRNA for interleukin-6 and tumor necrosis factor-alpha was higher with AEA but lower with DHA and docosahexaenoyl ethanolamide (DHEA), supporting previous findings that the EC AEA supports activation of the COX system. anandamide 180-183 interleukin 6 Homo sapiens 13-58 25712668-6 2015 However, priming of A549 cells with tectorigenin for 24h repressed A549 cell-induced secretion of TNF-alpha and IL-6 by THP-1 cells. tectorigenin 36-48 interleukin 6 Homo sapiens 112-116 25712668-7 2015 Tectorigenin induced change in functional phenotype of A549 cells rendered THP-1 cells non-responsive for the secretion of IL-6 and TNF-alpha in a contact co-culture setup. tectorigenin 0-12 interleukin 6 Homo sapiens 123-127 27260457-6 2016 When applied for the readout of sandwich interleukin 6 (IL-6) immunoassay, the plasmonically amplified EPF geometry designed for Alexa Fluor 647 labels offered 4-times higher fluorescence signal intensity compared to TIRF. Alexa Fluor 647 129-144 interleukin 6 Homo sapiens 41-54 25256809-7 2015 METHODS: Cultured normal human epidermal keratinocytes were exposed to chemical irritant phorbol 12-myrisate 13-acetate (TPA) or ultraviolet-B light (UVB) to induce pro-inflammatory cytokine (IL-6, IL-8 and TNF-alpha) production. phorbol 12-myrisate 13-acetate 89-119 interleukin 6 Homo sapiens 192-196 24591481-7 2014 In cartilage explants, palmitate induced chondrocyte death, IL-6 release, and ECM degradation. Palmitates 23-32 interleukin 6 Homo sapiens 60-64 27260457-6 2016 When applied for the readout of sandwich interleukin 6 (IL-6) immunoassay, the plasmonically amplified EPF geometry designed for Alexa Fluor 647 labels offered 4-times higher fluorescence signal intensity compared to TIRF. Alexa Fluor 647 129-144 interleukin 6 Homo sapiens 56-60 27354148-13 2016 In addition, the specific PI3K-inhibitor LY294002 decreased IL-6 secretion. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 41-49 interleukin 6 Homo sapiens 60-64 24874745-10 2014 Furthermore, orbital tissue was obtained from a patient with active GO, and the effect of dasatinib on the expression levels of HAS2-, CCL2-, IL6-, and IL8-mRNA expression was examined by real-time quantitative PCR. Dasatinib 90-99 interleukin 6 Homo sapiens 142-145 24874745-14 2014 In orbital tissue from active GO, dasatinib significantly suppressed HAS2-, CCL2-, IL6- and IL8-mRNA levels. Dasatinib 34-43 interleukin 6 Homo sapiens 83-86 25506811-5 2015 All polymers increased the production of interleukins 1 beta and 6 (IL-1beta and IL-6), but the oxovanadium complexes were more potent activators of these mediators. Polymers 4-12 interleukin 6 Homo sapiens 81-85 27453994-6 2016 Treatment with the inflammatory agents lipopolysaccharide (LPS) or palmitate augmented the secretion of many myokines including: GROa, IL6, IL8, IL15, and TNFa, but did not consistently alter the protein content and/or phosphorylation of IkBa, p44/42 MAPK, p38 MAPK, c-Jun N-terminal kinase (JNK) and NF-kB, nor lead to consistent changes in basal and insulin-stimulated glucose uptake or free fatty acid oxidation. Palmitates 67-76 interleukin 6 Homo sapiens 135-138 25740742-9 2015 Interleukin-6 and tumor necrosis factor-alpha levels and APACHE II score were significantly lower in the NIT group than in the NGT group (p<0.01, p<0.05). nit 105-108 interleukin 6 Homo sapiens 0-45 25031491-2 2014 In this study, an attempt was made to determine the serum level of IL6 in sulfur mustard (SM) injured patients and its comparison with controls. Mustard Gas 74-88 interleukin 6 Homo sapiens 67-70 28955928-6 2016 This study investigated the effect of cobalt on the secretion of inflammatory cytokines CCL20 and IL-6. Cobalt 38-44 interleukin 6 Homo sapiens 98-102 24845688-4 2014 In adjusted linear mixed models, metabolites of di-2-ethylhexyl phthalate (DEHP) were associated with increased IL-6 and IL-10 but relationships were generally not statistically significant. Diethylhexyl Phthalate 48-73 interleukin 6 Homo sapiens 112-116 24845688-4 2014 In adjusted linear mixed models, metabolites of di-2-ethylhexyl phthalate (DEHP) were associated with increased IL-6 and IL-10 but relationships were generally not statistically significant. Diethylhexyl Phthalate 75-79 interleukin 6 Homo sapiens 112-116 26557039-12 2015 The ions of cobalt released from the surface of the implant are absorbed by present macrophages, which are involved in many of the processes associated with phagocytose orthopaedic biomaterials particles and release pro-inflammatory mediators such as interleukin-1 (IL-1), interleukin-6 (IL-6), tumour necrosis factor alpha (TNF-alpha), and prostaglandin. Cobalt 12-18 interleukin 6 Homo sapiens 273-286 26557039-12 2015 The ions of cobalt released from the surface of the implant are absorbed by present macrophages, which are involved in many of the processes associated with phagocytose orthopaedic biomaterials particles and release pro-inflammatory mediators such as interleukin-1 (IL-1), interleukin-6 (IL-6), tumour necrosis factor alpha (TNF-alpha), and prostaglandin. Cobalt 12-18 interleukin 6 Homo sapiens 288-292 25561562-0 2015 Novel thiosemicarbazones regulate the signal transducer and activator of transcription 3 (STAT3) pathway: inhibition of constitutive and interleukin 6-induced activation by iron depletion. Thiosemicarbazones 6-24 interleukin 6 Homo sapiens 137-150 28955928-9 2016 Cobalt ions significantly increased release of CCL2 and IL-6 by MonoMac 6 cells (P<0.001). Cobalt 0-6 interleukin 6 Homo sapiens 56-60 25670984-10 2014 The production of IL-6 by LPS-activated moDC was also reduced significantly when eicosapentaenic acid was added as a RAMEA complex as compared to its DMSO-solubilized form or to the other two n-3 fatty acids either complexed or not. Fatty Acids, Omega-3 192-207 interleukin 6 Homo sapiens 18-22 26253096-11 2016 Finally, BCP crystals induced proteoglycan loss and IL-6 expression in human cartilage explants, which were reduced by an IL-6 inhibitor. bcp 9-12 interleukin 6 Homo sapiens 52-56 25548514-0 2014 Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway. gossypol acetic acid 26-32 interleukin 6 Homo sapiens 180-184 26253096-11 2016 Finally, BCP crystals induced proteoglycan loss and IL-6 expression in human cartilage explants, which were reduced by an IL-6 inhibitor. bcp 9-12 interleukin 6 Homo sapiens 122-126 26555013-6 2016 RESULTS: The highest UDNB was found when using the B cell assay in intermediate-risk patients (43%, ICER $5,314), while the IL-6 test in seronegative patients resulted in the lowest UDNB (-11.4%, ICER $7,650). udnb 182-186 interleukin 6 Homo sapiens 124-128 24614619-0 2014 The influence of total intravenous anaesthesia and isoflurane anaesthesia on plasma interleukin-6 and interleukin-10 concentrations after colorectal surgery for cancer: a randomised controlled trial. Isoflurane 51-61 interleukin 6 Homo sapiens 84-97 24614619-2 2014 OBJECTIVE: The aim of this present study was to compare the effects of total intravenous anaesthesia (TIVA) and isoflurane anaesthesia on plasma concentrations of interleukins IL-6 and IL-10 in patients undergoing surgery for colorectal cancer. tiva 102-106 interleukin 6 Homo sapiens 176-180 24614619-2 2014 OBJECTIVE: The aim of this present study was to compare the effects of total intravenous anaesthesia (TIVA) and isoflurane anaesthesia on plasma concentrations of interleukins IL-6 and IL-10 in patients undergoing surgery for colorectal cancer. Isoflurane 112-122 interleukin 6 Homo sapiens 176-180 24614619-13 2014 Intragroup comparisons revealed that IL-6 and IL-10 concentrations were significantly increased 2 and 24 h postoperatively in both groups when compared with their baseline values (P < 0.01 and P < 0.01 at 2 and 24 h for the TIVA group and isoflurane group, respectively). tiva 230-234 interleukin 6 Homo sapiens 37-41 27037808-7 2016 Both norepinephrine and dobutamine significantly reduced TNF-alpha and IL-6 production after ex vivo LPS stimulation of whole blood in a dose-dependent manner, and this effect was partially reversed by the presence of metoprolol. Dobutamine 24-34 interleukin 6 Homo sapiens 71-75 24614619-13 2014 Intragroup comparisons revealed that IL-6 and IL-10 concentrations were significantly increased 2 and 24 h postoperatively in both groups when compared with their baseline values (P < 0.01 and P < 0.01 at 2 and 24 h for the TIVA group and isoflurane group, respectively). Isoflurane 245-255 interleukin 6 Homo sapiens 37-41 26929249-6 2016 Further studies indicated that CS-IVa-Be is an antagonist of IL6 receptor via directly binding to the IL6Ralpha with a Kd of 663 +- 74 nmol/L and the GP130 (IL6Rbeta) with a Kd of 1,660 +- 243 nmol/L, interfering with the binding of IL6 to IL6R (IL6Ralpha and GP130) in vitro and in cancer cells. Cesium 31-33 interleukin 6 Homo sapiens 61-64 26929249-6 2016 Further studies indicated that CS-IVa-Be is an antagonist of IL6 receptor via directly binding to the IL6Ralpha with a Kd of 663 +- 74 nmol/L and the GP130 (IL6Rbeta) with a Kd of 1,660 +- 243 nmol/L, interfering with the binding of IL6 to IL6R (IL6Ralpha and GP130) in vitro and in cancer cells. Cesium 31-33 interleukin 6 Homo sapiens 102-105 25022448-9 2014 In conclusion, polymorphisms in IL6, TNF, IL10, IL17A and IFNG are associated with susceptibility to cSSSIs. csssis 101-107 interleukin 6 Homo sapiens 32-35 26929249-9 2016 Our findings suggest that CS-IVa-Be as a novel IL6R antagonist inhibits IL6/STAT3 signaling pathway and sensitizes the MDA-MB-231 cells to TRAIL-induced cell death. Cesium 26-28 interleukin 6 Homo sapiens 47-50 27262798-8 2016 Increased TF activity, and IL-6, MMP-3, and VEGF secretion induced by thrombin were inhibited by argatroban. argatroban 97-107 interleukin 6 Homo sapiens 27-31 25181692-12 2014 Of all cytokines expressed by TAMs, IL6 was increased at the highest level in human HCC co-cultures, compared with TAMs not undergoing co-culture. tams 30-34 interleukin 6 Homo sapiens 36-39 27403254-8 2016 Additionally, the highest dose of EGCG also led to a dramatic increase in TNF-alpha and IL-6 levels. epigallocatechin gallate 34-38 interleukin 6 Homo sapiens 88-92 25447760-3 2014 150 kGy gamma-irradiated genistein did not exert cytotoxicity in macrophages, and inhibited inducible nitric oxide synthase-mediated nitric oxide production and pro-inflammatory cytokines level, such as tumor necrosis factor-alpha, interleukin-6 and interleukin-1beta, in lipopolysaccharide (LPS)-induced macrophages. Genistein 25-34 interleukin 6 Homo sapiens 232-245 26272212-11 2016 In contrast, CS exposure resulted in significant increases in IL-1beta, IL-6, TNF-alpha expression, and oxidative stress. Cesium 13-15 interleukin 6 Homo sapiens 72-76 25319548-10 2014 Genistein significantly decreased IL-6 and IL-1beta mRNA levels, as well as IL-6 production in PMA/A23187-induced mast cells activation. Genistein 0-9 interleukin 6 Homo sapiens 34-38 25283329-4 2014 Palmitate enhanced ceramide accumulation and stimulated the expression and secretion of interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) in L1. Palmitates 0-9 interleukin 6 Homo sapiens 88-101 27016423-9 2016 Ex vivo studies further showed cefradine inhibited SUV-induced the phosphorylation level of p38, JNKs and H2AX through inhibiting TOPK activity in a dose and time dependent manner, and cefradine inhibited the secretion of IL6 and TNF-alpha in HaCat and JB6 cells. Cephradine 31-40 interleukin 6 Homo sapiens 222-225 25283329-4 2014 Palmitate enhanced ceramide accumulation and stimulated the expression and secretion of interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) in L1. Palmitates 0-9 interleukin 6 Homo sapiens 103-107 27016423-9 2016 Ex vivo studies further showed cefradine inhibited SUV-induced the phosphorylation level of p38, JNKs and H2AX through inhibiting TOPK activity in a dose and time dependent manner, and cefradine inhibited the secretion of IL6 and TNF-alpha in HaCat and JB6 cells. Cephradine 185-194 interleukin 6 Homo sapiens 222-225 25245200-7 2014 Pam3-Cys-SK4-stimulated secretion of interleukin-1beta (-35%, P = .005), interleukin-6 (-32%, P = .01), and tumor necrosis factor-alpha (-33%, P = .06) was reduced following the HFD. pam3-cys-sk4 0-12 interleukin 6 Homo sapiens 73-86 26988913-11 2016 Furthermore, IL-6 secreted by the cMSCs could polarize infiltrated TAMs into M2-like macrophages. tams 67-71 interleukin 6 Homo sapiens 13-17 25597175-4 2014 There was a significant negative correlation between the level of serum FSTL-1 and those of IL-6 and BMP6 in the BMPC patients, with correlation coefficients of -0.971 and -0.972, respectively (P < 0.05). Dimethylol-p-kresol 113-117 interleukin 6 Homo sapiens 92-96 26774572-7 2016 Interestingly, ASP- and PROP-containing substrates not only showed reduced adhesion of platelets and delayed coagulation time, but also drastically reduced the expression level of IL-8 and IL-6. Propolis 24-28 interleukin 6 Homo sapiens 189-193 25280408-11 2014 CONCLUSION: Carbohydrate or glutamine supplementation shifts the T helper (Th)1/Th2 balance toward Th1 responses after exercise at a simulated altitude of 4500 m. The nutritional strategies increased in IL-6, suggesting an important anti-inflammatory effect. Glutamine 28-37 interleukin 6 Homo sapiens 203-207 26179241-10 2016 RESULTS: IL-6 production was stimulated by G-HSA or LPS (p < 0.01), which was inhibited in both cases by NDM (p < 0.002). g-hsa 43-48 interleukin 6 Homo sapiens 9-13 24924589-4 2014 We show that I-BET151 is a potent, selective inhibitor of a number of NF-kB target genes involved in induction of inflammation and cell cycle regulation and downregulates production of cytokines such as IL-6 and IL-8. GSK1210151A 13-21 interleukin 6 Homo sapiens 203-207 26179241-11 2016 [G-HSA+LPS] synergistically stimulated IL-6 production (p < 0.0001), which was inhibited by NDM. g-hsa 1-6 interleukin 6 Homo sapiens 39-43 25105464-9 2014 Peripheral blood mononuclear cells showed a trend toward increased IL-6 gene expression after CDDO-Me treatment, whereas purified monocytes showed a trend toward decreased IL-6. bardoxolone methyl 94-101 interleukin 6 Homo sapiens 67-71 27007186-11 2016 IL-6 and TNF-alpha expressions were significantly lower in combined Ve with Omega-3 FA than treatment with Ve or Omega-3 FA alone. Fatty Acids, Omega-3 76-86 interleukin 6 Homo sapiens 0-4 25356049-8 2014 ELISA analysis revealed that oridonin down-regulated the inflammatory factors IL-1beta, IL-6, and IL-33 in a dose-dependent manner. oridonin 29-37 interleukin 6 Homo sapiens 88-92 27007186-11 2016 IL-6 and TNF-alpha expressions were significantly lower in combined Ve with Omega-3 FA than treatment with Ve or Omega-3 FA alone. Fatty Acids, Omega-3 113-123 interleukin 6 Homo sapiens 0-4 26949877-4 2016 RESULTS: Interleukin-6 plasma levels were higher in subjects exposed to silica with and without silicosis than in the control group. Silicon Dioxide 72-78 interleukin 6 Homo sapiens 9-22 25211490-12 2014 Compared to FS-LASIK group, lower and faster recovery of IL-6 and NGF levels in tears was observed in ReLEx smile group postoperatively (P<0.05). Fluorine 12-14 interleukin 6 Homo sapiens 57-61 26361990-11 2016 Interleukin-6 and -8 production, induced by 100muM SM was reduced by GSH/NAC. Mustard Gas 51-53 interleukin 6 Homo sapiens 0-20 24988892-5 2014 Most importantly, lung cancer cells themselves upregulated IL-6 secretion by activating the p38/NF-kappaB pathway through treatment with cisplatin and camptothecin. Camptothecin 151-163 interleukin 6 Homo sapiens 59-63 26719146-8 2016 Stimulation of BEAS-2B cells with supernatant of CS-induced necrotic cells induced a significant increase in the release of CXCL8 and IL-6, in a myeloid differentiation primary response gene 88-dependent fashion. Cesium 49-51 interleukin 6 Homo sapiens 134-138 24970314-8 2014 In the present study, inflammatory cytokine interleukin 6 (IL6) and its downstream activated signal transducer and activator of transcription 3 [phospho-STAT3(tyrosine705) and phospho-STAT3(serine727)] were downregulated after tanshinone IIA treatment in vitro and in vivo. tyrosine705 159-170 interleukin 6 Homo sapiens 44-57 24970314-8 2014 In the present study, inflammatory cytokine interleukin 6 (IL6) and its downstream activated signal transducer and activator of transcription 3 [phospho-STAT3(tyrosine705) and phospho-STAT3(serine727)] were downregulated after tanshinone IIA treatment in vitro and in vivo. tyrosine705 159-170 interleukin 6 Homo sapiens 59-62 24970314-8 2014 In the present study, inflammatory cytokine interleukin 6 (IL6) and its downstream activated signal transducer and activator of transcription 3 [phospho-STAT3(tyrosine705) and phospho-STAT3(serine727)] were downregulated after tanshinone IIA treatment in vitro and in vivo. serine727 190-199 interleukin 6 Homo sapiens 44-57 24970314-8 2014 In the present study, inflammatory cytokine interleukin 6 (IL6) and its downstream activated signal transducer and activator of transcription 3 [phospho-STAT3(tyrosine705) and phospho-STAT3(serine727)] were downregulated after tanshinone IIA treatment in vitro and in vivo. serine727 190-199 interleukin 6 Homo sapiens 59-62 26849807-13 2016 Further, short-term rottlerin treatment reduced both PaSC fibrogenic potential and IL-6 mRNA expression. rottlerin 20-29 interleukin 6 Homo sapiens 83-87 24515724-7 2014 Furthermore, bufalin attenuated the TNF-alpha-induced interleukin-1beta (IL-1beta), IL-6, and IL-8 production in RAFLSs in a concentration-dependent manner. bufalin 13-20 interleukin 6 Homo sapiens 84-88 26510945-0 2016 IL6-induced metastasis modulators p-STAT3, MMP-2 and MMP-9 are targets of 3,3"-diindolylmethane in ovarian cancer cells. 3,3'-diindolylmethane 74-95 interleukin 6 Homo sapiens 0-3 25069913-8 2014 Gln also up-regulated expression of interleukin-6, interleukin-8, MCP-1, MIP-3alpha, CCL2, CCL20, and CXCL1. Glutamine 0-3 interleukin 6 Homo sapiens 36-49 24793913-0 2014 Involvement of P2Y11 receptor in silica nanoparticles 30-induced IL-6 production by human keratinocytes. Silicon Dioxide 33-39 interleukin 6 Homo sapiens 65-69 24793913-2 2014 In this study, the involvement of various P2 receptors in IL-6 production induced by silica nanoparticle 30 (SNP30) was examined in a human keratinocyte cell line, HaCaT. Silicon Dioxide 85-91 interleukin 6 Homo sapiens 58-62 26485167-4 2016 LH gels incorporating cGAMP (LH/cGAMP gels) elicited excellent induction of the cytokines interferon-beta (IFN-beta) and interleukin-6 (IL-6). Luteinizing Hormone 0-2 interleukin 6 Homo sapiens 121-134 25064094-0 2014 Treatment with pirfenidone for two years decreases fibrosis, cytokine levels and enhances CB2 gene expression in patients with chronic hepatitis C. BACKGROUND: The aim of this study was to assess whether two-years treatment with Pirfenidone influences necroinflammation, fibrosis and steatosis, serum levels of TGF-beta1, IL-6, TNF-alpha and CB1 and CB2 gene expression, in patients with chronic hepatitis C (CHC). pirfenidone 15-26 interleukin 6 Homo sapiens 322-326 25064094-0 2014 Treatment with pirfenidone for two years decreases fibrosis, cytokine levels and enhances CB2 gene expression in patients with chronic hepatitis C. BACKGROUND: The aim of this study was to assess whether two-years treatment with Pirfenidone influences necroinflammation, fibrosis and steatosis, serum levels of TGF-beta1, IL-6, TNF-alpha and CB1 and CB2 gene expression, in patients with chronic hepatitis C (CHC). pirfenidone 229-240 interleukin 6 Homo sapiens 322-326 26485167-4 2016 LH gels incorporating cGAMP (LH/cGAMP gels) elicited excellent induction of the cytokines interferon-beta (IFN-beta) and interleukin-6 (IL-6). Luteinizing Hormone 0-2 interleukin 6 Homo sapiens 136-140 26578520-5 2016 Compared with normoxia, hypoxia significantly increased palmitate-induced mRNA expression and protein secretion of IL-6 and IL-1beta. Palmitates 56-65 interleukin 6 Homo sapiens 115-119 24704296-3 2014 We demonstrated that DHMEQ down-regulated the NF-kappaB target genes IRF4 and CD40, the secretion of IL-6, CCL5, CCL17 and generated ROS. dehydroxymethylepoxyquinomicin 21-26 interleukin 6 Homo sapiens 101-105 27579328-9 2016 Plasma IL-8 and IL-6 levels were significantly higher in patients with PaO2/FiO2 <= 200 mmHg and nonsurvivors than in those with PaO2/FiO2 > 200 mmHg and survivors. fio2 76-80 interleukin 6 Homo sapiens 16-20 24591481-6 2014 RESULTS: Palmitate, but not oleate, induced caspase activation and cell death in IL-1beta-stimulated normal chondrocytes, and up-regulated the expression of IL-6 and cyclooxygenase 2 in chondrocytes and fibroblast-like synoviocytes through Toll-like receptor 4 (TLR-4) signaling. Palmitates 9-18 interleukin 6 Homo sapiens 157-161 27980357-7 2016 Interleukin-6 resulted in a dose-dependent decrease in the TER and an increase in the FITC-dextran permeability; however, pretreatment with 400 microg/ml KIOM-MA/MA128 resulted in a significant increase in the TER and a decrease in the FITC-dextran permeability via IL-6 induction. fluorescein isothiocyanate dextran 86-98 interleukin 6 Homo sapiens 0-13 24499830-8 2014 The median IL-6 level increased from 0.8 to 36.3 pg/dl in the ODG group and from 1.5 to 53.3 pg/dl in the LADG group. BMP15 protein, human 62-65 interleukin 6 Homo sapiens 11-15 27980357-7 2016 Interleukin-6 resulted in a dose-dependent decrease in the TER and an increase in the FITC-dextran permeability; however, pretreatment with 400 microg/ml KIOM-MA/MA128 resulted in a significant increase in the TER and a decrease in the FITC-dextran permeability via IL-6 induction. fluorescein isothiocyanate dextran 236-248 interleukin 6 Homo sapiens 0-13 24429914-0 2014 Dexmedetomidine inhibits tumor necrosis factor-alpha and interleukin 6 in lipopolysaccharide-stimulated astrocytes by suppression of c-Jun N-terminal kinases. Dexmedetomidine 0-15 interleukin 6 Homo sapiens 57-70 24038588-3 2014 The results showed that the JAK/STAT pathway activation by proinflammatory cytokine interleukin-6 and interferon-gamma in CCA cells was suppressed by pretreatment with quercetin and EGCG, evidently by a decrease of the elevated phosphorylated-STAT1 and STAT3 proteins in a dose-dependent manner. epigallocatechin gallate 182-186 interleukin 6 Homo sapiens 84-97 26613389-13 2015 Combinations of BMI >= 30 with elevated IL-6, IL-8, hsCRP, TNF-alpha, and leptin predicted improved response to L-methylfolate calcium in MDD patients with an inadequate antidepressant response. levomefolate calcium 115-137 interleukin 6 Homo sapiens 43-47 24704334-8 2014 GMMA from the production strain had 50-fold lower ability to stimulate IL-6 release from human PBMC and caused 1000-fold lower TLR-4 activation in Human Embryonic Kidney cells than non-detoxified GMMA. gmma 0-4 interleukin 6 Homo sapiens 71-75 24429914-4 2014 This study was designed to evaluate the effects of DEX on tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6) gene expressions in LPS-challenged astrocytes. Dexmedetomidine 51-54 interleukin 6 Homo sapiens 102-115 24429914-4 2014 This study was designed to evaluate the effects of DEX on tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6) gene expressions in LPS-challenged astrocytes. Dexmedetomidine 51-54 interleukin 6 Homo sapiens 117-121 24429914-7 2014 With real-time PCR assay, we found that LPS significantly increased expressions of TNF-alpha and IL-6 in mRNA level; however, these effects could be attenuated by DEX. Dexmedetomidine 163-166 interleukin 6 Homo sapiens 97-101 24429914-8 2014 Furthermore, JNK pathway might be involved in LPS-induced astrocyte activation because JNK phosphorylation was significantly increased, and the inhibition of this pathway mediated by DEX as well as SP600125 (JNK inhibitor) decreased TNF-alpha and IL-6 expressions. Dexmedetomidine 183-186 interleukin 6 Homo sapiens 247-251 26572585-4 2015 EC overexpression of mutant ITGB4 with specific tyrosines mutated to phenylalanine (Y1440, Y1526 Y1640, or Y1422) resulted in significantly attenuated CS-induced cytokine expression (IL6, IL-8, MCP-1, and RANTES). Cesium 151-153 interleukin 6 Homo sapiens 183-186 24861949-6 2014 A significant correlation (r = 0.78, p = 0.001) was observed between EBC levels of IL-6 and IL-17; IL-17 was also correlated to EBC levels of the VEGF (r = 0.83, p < 0.001) and TNF-alpha (r = 0.62, p = 0.014). NSC638702 69-72 interleukin 6 Homo sapiens 83-87 24885636-13 2014 CONCLUSIONS: Our findings suggested that TAMs participate in the metastasis of CRC induced by PRL-3 through the TNF-alpha mediated secretion of IL-6 and IL-8 in a paracrine manner. tams 41-45 interleukin 6 Homo sapiens 144-148 26884987-7 2015 Our results showed that beta-asarone attenuated inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6 production. asarone 24-36 interleukin 6 Homo sapiens 156-160 24370115-0 2014 Ultrasensitive IL-6 electrochemical immunosensor based on Au nanoparticles-graphene-silica biointerface. Silicon Dioxide 84-90 interleukin 6 Homo sapiens 15-19 24370115-1 2014 An Interleukin-6 (IL-6) electrochemical immunosensor was fabricated based on the Au nanoparticles (AuNP)-graphene-silica sol-gel as immobilization biointerface and AuNP-polydopamine (PDA)@carbon nanotubes (CNT) as the label of HRP-bound antibodies. Silicon Dioxide 114-120 interleukin 6 Homo sapiens 3-16 24033792-8 2014 However, under UVB exposure, the non-functionalized silica nanoparticles altered the release of IL-6. Silicon Dioxide 52-58 interleukin 6 Homo sapiens 96-100 26528725-8 2015 Furthermore, interleukin-6 (IL-6)-induced STAT3 activation was strongly suppressed by salinomycin challenge. salinomycin 86-97 interleukin 6 Homo sapiens 13-26 24164541-1 2014 Aerosolized exposure to the chemical warfare vesicant sulfur mustard and its analog nitrogen mustard (HN2) is known to induce airway lesions associated with secretion of proinflammatory cytokines such as IL-6. Mustard Gas 54-68 interleukin 6 Homo sapiens 204-208 24415766-4 2014 Two classes of IL-6 SOMAmers were isolated from modified DNA libraries containing 40 random positions and either 5-(N-benzylcarboxamide)-2"-deoxyuridine (Bn-dU) or 5-[N-(1-naphthylmethyl)carboxamide]-2"-deoxyuridine (Nap-dU) replacing dT. nap-du 217-223 interleukin 6 Homo sapiens 15-19 24415766-4 2014 Two classes of IL-6 SOMAmers were isolated from modified DNA libraries containing 40 random positions and either 5-(N-benzylcarboxamide)-2"-deoxyuridine (Bn-dU) or 5-[N-(1-naphthylmethyl)carboxamide]-2"-deoxyuridine (Nap-dU) replacing dT. Thymidine 235-237 interleukin 6 Homo sapiens 15-19 26528725-8 2015 Furthermore, interleukin-6 (IL-6)-induced STAT3 activation was strongly suppressed by salinomycin challenge. salinomycin 86-97 interleukin 6 Homo sapiens 28-32 24605247-10 2014 IL-6 levels were found statistically significant, elevated after 2 and 24 hours from the URS (P < 0.001). Peptichemio 89-92 interleukin 6 Homo sapiens 0-4 24332681-4 2014 Our results demonstrate that silica-exposed individuals present important alterations in their immune response when compared to controls, as shown by increased serum sIL-2R levels, decreased production of IL-2 and increased levels of the pro-inflammatory (IFN-gamma, IL-1alpha, TNF-alpha, IL-6) as well as anti-inflammatory (IL-10 and TGF-beta) cytokines. Silicon Dioxide 29-35 interleukin 6 Homo sapiens 289-293 26220057-5 2015 The sequential drug release of LDC and THD from the developed LDC-THD-GO nanosheets exhibited a synergistic effect on neuropathic pain in vitro and in vivo, as evidenced by the increased pain threshold in mechanical allodynia and hyperalgesic response tests, and the improved inhibition of proinflammatory cytokines TNF-alpha, IL-1beta, IL-6, and nitric oxide. Thalidomide 39-42 interleukin 6 Homo sapiens 337-341 24363043-8 2014 Treatment with PKA selective 6-Bnz-cAMP or Epac selective 8-CPT-2Me-cAMP cAMP analogs revealed a predominant role for PKA in cAMP-mediated induction of IL-6. Bz-Camp 29-39 interleukin 6 Homo sapiens 152-156 25159306-8 2014 RESULTS: The yields of DHT from 14C-testosterone showed 2-fold and 1.8-fold- inhibition in response to IL-6 and CRP respectively and 28% stimulation in response to Dox, via the 5-alpha reductase pathway. 14c-testosterone 32-48 interleukin 6 Homo sapiens 103-107 26341987-6 2015 Sputum interleukin (IL)-6 and growth-regulated oncogene (GRO)-alpha and serum GRO-alpha, IL-1ss and IL-8 levels increased with AZD5069 versus placebo (all p<0.001), while serum high-sensitivity C-reactive protein levels did not change. N-(2-(2,3-difluoro-6-benzylthio)-6-(3,4-dihydroxybutan-2-yloxy)pyrimidin-4-yl)azetidine-1-sulfonamide 127-134 interleukin 6 Homo sapiens 7-25 23952478-7 2014 Morin significantly decreased the production of tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 in the UVB-irradiated KSC. kappa-selenocarrageenan 136-139 interleukin 6 Homo sapiens 100-113 24664372-0 2014 Celastrol blocks interleukin-6 gene expression via downregulation of NF-kappaB in prostate carcinoma cells. celastrol 0-9 interleukin 6 Homo sapiens 17-30 24664372-3 2014 In this study, we evaluated the molecular mechanisms of celastrol on cell proliferation and IL-6 gene expression in prostate carcinoma cells. celastrol 56-65 interleukin 6 Homo sapiens 92-96 26672717-13 2015 In conclusion, high pre ESWL/URS levels of serum TNF-a and IL-6 may indicate a predisposition for post ESWL/URS inflammation and infection following URS lithotripsy or ESWL procedure. Peptichemio 29-32 interleukin 6 Homo sapiens 59-63 24669186-8 2014 RESULTS: Genistein decreased the secretion of IL-1beta, IL-6, and IL-8 from TNF-alpha-stimulated MH7A cells in a dose-dependent manner. Genistein 9-18 interleukin 6 Homo sapiens 56-60 24669186-10 2014 The production of IL-1beta, IL-6, and IL-8 induced by TNF-alpha was decreased by the phosphatidylinositol-3 kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6, and IL-8 production induced by TNF-alpha. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 125-133 interleukin 6 Homo sapiens 28-32 24669186-10 2014 The production of IL-1beta, IL-6, and IL-8 induced by TNF-alpha was decreased by the phosphatidylinositol-3 kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6, and IL-8 production induced by TNF-alpha. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 125-133 interleukin 6 Homo sapiens 204-208 24549094-13 2014 NaCl 7.2%/6% hydroxyethyl starch 200/0.5 significantly reduces levels of IL-6 and IL-10 at 4 h after cardiopulmonary bypass and intercellular adhesion molecule 1 and E-selectin at 4 h after cardiopulmonary bypass and on postoperative day 1 (P < 0.05 for all). Hydroxyethyl starch 13-32 interleukin 6 Homo sapiens 73-77 24803982-3 2014 The levels of NO, IL-6, TNF-alpha, and MDA were higher in supernatant of palmitate stimulated blood cells (PBMNC) or from plasma from patients. Palmitates 73-82 interleukin 6 Homo sapiens 18-22 25539549-6 2014 The mean interleukin-6 and tumor necrosis factor-alpha levels for inflammation markers in EBC before and after treatment were 1.03 +- 1.1, 0.77 +- 0.8 pg/mL (P = 0.41) and 27.8 +- 2.6, 29.2 +- 5.7 pg/mL (P = 0.36) respectively. NSC638702 90-93 interleukin 6 Homo sapiens 9-54 26317519-6 2015 Few statistically significant associations or clear trends were observed, although in full models mono-carboxypropyl phthalate (MCPP) was significantly (percent change with interquartile range increase in exposure [%Delta] = 8.89, 95% confidence interval [CI] = 3.28, 14.8), and mono-benzyl phthalate (MBzP) was suggestively (%Delta = 6.79, 95%CI = -1.21, 15.4) associated with IL-6. mecoprop 128-132 interleukin 6 Homo sapiens 378-382 23933845-3 2013 The aim of this study was to explore the effects of PT and the peptidomimetic natural products, Dhurrin and Prunasin, on the expression of the IL-6, IL-8, IL-23, HSP70 and ICAM-1 on IFN-gamma and TNF-alpha-NHEK activated cells. Peptide T 52-54 interleukin 6 Homo sapiens 143-147 23933845-3 2013 The aim of this study was to explore the effects of PT and the peptidomimetic natural products, Dhurrin and Prunasin, on the expression of the IL-6, IL-8, IL-23, HSP70 and ICAM-1 on IFN-gamma and TNF-alpha-NHEK activated cells. dhurrin 96-103 interleukin 6 Homo sapiens 143-147 24641842-0 2014 [Regulatory effect of miR-149 on interleukin-6 expression in silica-induced pulmonary fibrosis]. Silicon Dioxide 61-67 interleukin 6 Homo sapiens 33-46 24641842-1 2014 OBJECTIVE: To investigate the regulatory effect of miR-149 on interleukin-6 (IL-6) expression in silica-induced pulmonary fibrosis. Silicon Dioxide 97-103 interleukin 6 Homo sapiens 62-75 24641842-1 2014 OBJECTIVE: To investigate the regulatory effect of miR-149 on interleukin-6 (IL-6) expression in silica-induced pulmonary fibrosis. Silicon Dioxide 97-103 interleukin 6 Homo sapiens 77-81 24641842-6 2014 RESULTS: At three time points after silica treatment, the miR-149 expression in lung tissues was significantly down-regulated while an evident increase in IL-6 expression was observed in lung tissues (P < 0.01). Silicon Dioxide 36-42 interleukin 6 Homo sapiens 155-159 25967348-7 2015 Consistent with histology results, EGCG treatment significantly inhibited MCD diet-induced IL-1beta, IL-6, TNF-alpha and MCP-1 mRNA expression. epigallocatechin gallate 35-39 interleukin 6 Homo sapiens 101-105 24641842-7 2014 Silica-stimulated epithelial cell (A549 and HBE) had up-regulated IL-6 expression and down-regulated miR-149 expression (P < 0.01). Silicon Dioxide 0-6 interleukin 6 Homo sapiens 66-70 24641842-10 2014 CONCLUSION: Down-regulation of miR-149 and up-regulation of IL-6 might be involved in the progression of silica-induced pulmonary fibrosis; miR-149 could negatively regulate IL-6 expression. Silicon Dioxide 105-111 interleukin 6 Homo sapiens 60-64 24641842-10 2014 CONCLUSION: Down-regulation of miR-149 and up-regulation of IL-6 might be involved in the progression of silica-induced pulmonary fibrosis; miR-149 could negatively regulate IL-6 expression. Silicon Dioxide 105-111 interleukin 6 Homo sapiens 174-178 24072000-12 2013 Through the short-term impact of chlorine e6-PDI on IL-6 and IL-8 secretion, PDI may inhibit the inflammatory cascade in at least keratocyte cultures. Chlorine 33-41 interleukin 6 Homo sapiens 52-56 25722296-9 2015 Compared with efavirenz, protease inhibitors were associated with higher and nevirapine with lower IL-6 levels. Nevirapine 77-87 interleukin 6 Homo sapiens 99-103 23897118-8 2013 We further find that microRNA-146a knockdown by antagomirs or protein phosphatase inhibition by okadaic acid increases p38 MAPK phosphorylation and results in RBM4 serine-309 phosphorylation and nuclear relocalization, which disrupts RBM4 and Ago2 interactions and restores TLR4-dependent synthesis of TNFalpha and IL-6. Okadaic Acid 96-108 interleukin 6 Homo sapiens 315-319 24505395-0 2014 Effect of marine-derived n-3 polyunsaturated fatty acids on C-reactive protein, interleukin 6 and tumor necrosis factor alpha: a meta-analysis. Fatty Acids, Omega-3 25-56 interleukin 6 Homo sapiens 80-125 26379954-8 2015 One- and five-day after operation, the levels of TNF-alpha, NSE and IL-6 in the dexmedetomidine group were significantly lower than those in the control group (P<0.05), and serum SOD significantly increased in the former (P<0.05). Dexmedetomidine 80-95 interleukin 6 Homo sapiens 68-72 24505395-4 2014 Marine-derived n-3 PUFAs supplementation showed a lowering effect on Marine-derived n-3 PUFAs supplementation had a significant lowering effect on TNF-alpha, IL-6 and CRP in three groups of subjects (subjects with chronic non-autoimmune disease, subjects with chronic autoimmune disease and healthy subjects). Fatty Acids, Omega-3 15-24 interleukin 6 Homo sapiens 158-162 24505395-4 2014 Marine-derived n-3 PUFAs supplementation showed a lowering effect on Marine-derived n-3 PUFAs supplementation had a significant lowering effect on TNF-alpha, IL-6 and CRP in three groups of subjects (subjects with chronic non-autoimmune disease, subjects with chronic autoimmune disease and healthy subjects). Fatty Acids, Omega-3 84-93 interleukin 6 Homo sapiens 158-162 24505395-8 2014 The effect of marine-derived n-3 PUFAs from dietary intake was only assessed in subjects with chronic non-autoimmune disease, and a significant lowering effect was observed on IL-6, but not on CRP and TNF-alpha. Fatty Acids, Omega-3 29-38 interleukin 6 Homo sapiens 176-180 24505395-9 2014 CONCLUSIONS: Marine-derived n-3 PUFAs supplementation had a significant lowering effect on CRP, IL-6 and TNF-alpha level. Fatty Acids, Omega-3 28-37 interleukin 6 Homo sapiens 96-100 23947625-7 2013 Pyrrolidine dithiocarbamate inhibited NF-kappaB activation, resulting in the down-regulation of nuclear NF-kappaB protein, which led to the down-regulation of the mRNA and protein levels of TNF-alpha and IL-6. pyrrolidine dithiocarbamic acid 0-27 interleukin 6 Homo sapiens 204-208 23910957-0 2013 Aqueous synthesis of color-tunable CuInS2/ZnS nanocrystals for the detection of human interleukin 6. cuins2 35-41 interleukin 6 Homo sapiens 86-99 25944880-10 2015 Palmitate, but not palmitoleate, elevated the expression of IL-6, IL-8, TLR2 (Toll-like receptor 2), and intercellular adhesion molecule 1 (ICAM-1). Palmitates 0-9 interleukin 6 Homo sapiens 60-64 23207169-9 2013 Univariate and multivariate analyses revealed higher pleural IL-6 levels were associated with postoperative minimum PaO2/FiO2 ratio. fio2 121-125 interleukin 6 Homo sapiens 61-65 24307657-3 2014 This study aimed to test whether overexpression of IL-6 and constitutive activation of Stat3 in prostate cancer cells increase resistance to enzalutamide. enzalutamide 141-153 interleukin 6 Homo sapiens 51-55 24307657-8 2014 RESULTS: Prostate cancer cells expressing autocrine IL-6 are resistant to enzalutamide and autocrine IL-6 leads to constitutive activation of Stat3 and its target genes. enzalutamide 74-86 interleukin 6 Homo sapiens 52-56 24307657-13 2014 CONCLUSIONS: This study demonstrates that the autocrine IL-6 pathway induces enzalutamide resistance in prostate cancer cells via the constitutive activation of Stat3. enzalutamide 77-89 interleukin 6 Homo sapiens 56-60 24307657-14 2014 Co-targeting IL6-Stat3 pathway with enzalutamide may be utilized for treatment of advanced prostate cancer. enzalutamide 36-48 interleukin 6 Homo sapiens 13-16 26028838-0 2015 A prospective study to assess the levels of interleukin-6 following administration of diclofenac, ketorolac and tramadol after surgical removal of lower third molars. Tramadol 112-120 interleukin 6 Homo sapiens 44-57 24400858-5 2014 Treatment of primary neonatal human keratinocytes with 1 followed by activation with phorbol ester/ionomycin showed a significant reduction in IL-6 secretion. Phorbol Esters 85-98 interleukin 6 Homo sapiens 143-147 23361365-4 2013 The aims of this study were to examine the effect of the n-3 PUFAs, docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA), on the modulation of IL-6-induced CRP expression and to explore its possible mechanisms. Fatty Acids, Omega-3 57-66 interleukin 6 Homo sapiens 150-154 23498057-0 2013 Glutamine and alanine-induced differential expression of intracellular IL-6, IL-8, and TNF-alpha in LPS-stimulated monocytes in human whole-blood. Glutamine 0-9 interleukin 6 Homo sapiens 71-75 23498057-7 2013 Our investigations showed for the first time in whole blood probes, imitating best physiologically present cellular interactions, that l-glutamine caused a dose-independent inhibitory effect on IL-6 and TNF-alpha production in human monocytes stimulated with LPS. Glutamine 135-146 interleukin 6 Homo sapiens 194-198 26028838-7 2015 AIM: To evaluate the changes in serum IL-6 levels following surgical removal of third molars under local anaesthesia after administration of two NSAIDs diclofenac and ketorolac and opioid tramadol post operatively. Tramadol 188-196 interleukin 6 Homo sapiens 38-42 23498057-12 2013 For the regulation of TNF-alpha, l-glutamine, l-alanine and the combination of both show a congruent and exponentiated downregulating effect during endotoxemia, for the modulation of IL-6, l-glutamine and l-alanine featured opposite regulation leading to a canceling impact of each other when recombining both amino acids. Glutamine 33-44 interleukin 6 Homo sapiens 183-187 26028838-11 2015 RESULTS: The results of our study showed that all three drugs i.e. diclofenac, ketorolac and tramadol have properties which can downregulate the production of IL-6 in response to surgical trauma. Tramadol 93-101 interleukin 6 Homo sapiens 159-163 24481022-0 2014 Chlorin e6 Conjugated Interleukin-6 Receptor Aptamers Selectively Kill Target Cells Upon Irradiation. phytochlorin 0-10 interleukin 6 Homo sapiens 22-35 26028838-12 2015 CONCLUSION: It is of clinical significance that the suppression of IL-6 values occurs in tramadol group closely following the diclofenac group. Tramadol 89-97 interleukin 6 Homo sapiens 67-71 26028838-13 2015 Even though the drug ketorolac suppresses the IL-6 levels similar to diclofenac initially but after 7 days tramadol and ketorolac showed similarities in suppression of IL-6 expression which is less compared to diclofenac group. Tramadol 107-115 interleukin 6 Homo sapiens 168-172 25626894-9 2015 The present findings suggest that GEN protects HCY-induced endothelial cell inflammatory injury may through reducing the release of ROS, inhibiting NF-kB activation, down-regulating the expression of cytokine IL-6 and adhesion molecules ICAM-1, avoiding inflammatory cells and platelet adhesion, accordingly, leading to a balance of endothelial cell proliferation and apoptosis. Genistein 34-37 interleukin 6 Homo sapiens 209-213 25162011-3 2014 We assessed the ability of EA and RA to modulate IL-1beta, IL-6, IL-8, IL-10, MCP-1, and TNF-alpha gene expression in HaCaT cells after UVB irradiation. Ellagic Acid 27-29 interleukin 6 Homo sapiens 59-63 23179989-7 2013 There was also a trend of an increase in interleukin (IL)-6 in blood, ethane in exhaled air, and IL-1beta in EBC after exposure to cooking fumes. NSC638702 109-112 interleukin 6 Homo sapiens 41-59 25749497-12 2015 In vitro studies revealed that Thal decreased 1) the expression of IL-1beta and IL-6 in human lung epithelial cells, and 2) CSE-induced apoptosis and the inhibition of cell growth, which may be the underlying mechanisms for the preventative effects of Thal on emphysema. Thalidomide 31-35 interleukin 6 Homo sapiens 80-84 23161148-8 2013 AG490, PD98059, or LY294002, inhibitors specific for the intracellular signals, JAK, MAPK, and PI3K, respectively, partially blocked these IL-6 neuroprotective effects. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 19-27 interleukin 6 Homo sapiens 139-143 23161148-10 2013 The enhanced activation of STAT3, ERK1/2, and AKT by IL-6 was abolished by AG490, PD98059, and LY294002, respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 95-103 interleukin 6 Homo sapiens 53-57 24791862-9 2014 Additionally, the value of PASP in the PH group was confirmed to be positively correlated with the increase in the levels of IL-6 and 8-iso-PSG in both EBC and serum (r = 0.477-0.589, P < 0.05). NSC638702 152-155 interleukin 6 Homo sapiens 125-129 24791862-10 2014 CONCLUSION: The increase in the levels of IL-6 and 8-iso-PSG in EBC and serum correlates with the pathogenesis of PH in COPD. NSC638702 64-67 interleukin 6 Homo sapiens 42-46 24946751-9 2015 Treatment with SC-514 reduced the elevated levels of pro-inflammatory cytokines (TNF-alpha and IL-6), iNOS, and COX-2. SC 514 15-21 interleukin 6 Homo sapiens 95-99 24555677-7 2014 Exposure of THP-1 cells to both sizes of ZnO stimulated and increased release of proinflammatory cytokines interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, and IL-6, as well as chemokine IL-8, and upregulated the expression of monocyte chemoattractant protein-1 and cyclooxygenase-2 genes. Zinc Oxide 41-44 interleukin 6 Homo sapiens 170-174 23261764-6 2013 Furthermore, inhibition of TNF-alpha synthesis by intraperitoneal thalidomide prevented both mechanical allodynia and the up-regulation of IL-6 in DRGs following L5-VRT. Thalidomide 66-77 interleukin 6 Homo sapiens 139-143 25125502-6 2015 Multiple regression models controlling for age, gender, and grade point average revealed a negative relationship between PSS and GCS for vaccine-stimulated production of IL-1beta, IL-6, and TNF-alpha. pss 121-124 interleukin 6 Homo sapiens 180-184 23190749-8 2013 In addition, kakkalide inhibited ROS-associated inflammation in the endothelium by inhibiting tumor necrosis factor-alpha and interleukin-6 production and gene expression, as well as suppressing the phosphorylation of c-Jun N-terminal kinase and IkappaB kinase beta/nuclear factor-kappaB. kakkalide 13-22 interleukin 6 Homo sapiens 126-139 24122993-5 2013 UA also inhibited the activation of STAT3 induced by interleukin-6 in DLD-1 colon cancer cells. ursolic acid 0-2 interleukin 6 Homo sapiens 53-66 25889552-9 2015 Maqui extract significantly decreased H2O2 (p < 0.0002) and increased IL-6 (p < 0.004) in the EBC from smokers. NSC638702 100-103 interleukin 6 Homo sapiens 73-77 23683266-0 2013 Omega-3 fatty acid therapy reduces triglycerides and interleukin-6 in hypertriglyeridemic HIV patients. Fatty Acids, Omega-3 0-18 interleukin 6 Homo sapiens 53-66 23947625-3 2013 The effects of the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) and TLR3-neutralizing antibody on the expression of NF-kappaB, TNF-alpha, and IL-6 were investigated. pyrrolidine dithiocarbamic acid 68-72 interleukin 6 Homo sapiens 152-156 23232112-4 2013 The neutralization of extracellular BDNF abolished the IL-6 effect and the treatment with IL-6 and CHA (an agonist of A1R) modulated BDNF expression as well as pCREB and pTrkB levels. ptrkb 170-175 interleukin 6 Homo sapiens 90-102 25889552-10 2015 The EBC concentrations of H2O2 and IL-6 after maqui administration did not differ between smokers and non-smokers. NSC638702 4-7 interleukin 6 Homo sapiens 35-39 24078927-0 2013 Synthesis of a novel thiazolidinedione and evaluation of its modulatory effect on IFN- gamma , IL-6, IL-17A, and IL-22 production in PBMCs from rheumatoid arthritis patients. 2,4-thiazolidinedione 21-38 interleukin 6 Homo sapiens 95-99 23843452-6 2013 Furthermore, this dysbiosis was evident among HIV-infected subjects undergoing HAART, and the extent of dysbiosis correlated with activity of the kynurenine pathway of tryptophan catabolism and plasma concentrations of the inflammatory cytokine interleukin-6 (IL-6), two established markers of disease progression. Kynurenine 146-156 interleukin 6 Homo sapiens 260-264 25889552-11 2015 CONCLUSIONS: Maqui extract normalizes IL-6 and H2O2 concentrations in EBC from humans with mild smoking habits. NSC638702 70-73 interleukin 6 Homo sapiens 38-42 22954322-7 2013 Whereas the poly(I:C)-induced secretion of IL-6, IP-10, and RANTES was inhibited by both IKK-2 inhibitor and LY294002, that of IL-8 was blocked only by IKK-2 inhibitor. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 109-117 interleukin 6 Homo sapiens 43-47 25732404-5 2015 We found that EGCG dose-dependently inhibited LPS stimulation of adipocyte inflammation by reducing inflammatory mediator and cytokine levels (IKKbeta, p-NF-kappaB, TNF-alpha, and IL-6). epigallocatechin gallate 14-18 interleukin 6 Homo sapiens 180-184 22496403-6 2013 Based on our classification of presence/absence of SMI in our diabetic group, we found that there was a significant association between SMI and the biomarkers IL-6 (p < 0.001), leptin (p < 0.001) and OPG (p < 0.05). SMI496 136-139 interleukin 6 Homo sapiens 159-163 23564015-4 2013 Our results indicated that murrayafoline A derivatives containing 1,2,3-triazole nucleus potentially possessed anti-inflammatory action through inhibiting production of IL-6, IL-12 p40 and TNF-alpha. murrayafoline A 27-42 interleukin 6 Homo sapiens 169-173 26356264-7 2015 In contrast, the levels of TNF-alpha and IL-6 secreted by PBMC in the RE group were suppressed compared with those in SC group following non-microbial antigen stimulation (concanavalin A or alpha-galactosylceramide). alpha-galactosylceramide 190-214 interleukin 6 Homo sapiens 41-45 24053005-6 2013 The mean serum concentrations of IL-2 and IL-6 were found to be significantly elevated in the control compared with the SM group (P < .05). Mustard Gas 120-122 interleukin 6 Homo sapiens 42-46 24053005-9 2013 Serum concentrations of IL-2, IL-6, and IL-10 are significantly decreased in SM-exposed patients with chronic pruritus. Mustard Gas 77-79 interleukin 6 Homo sapiens 30-34 22971992-11 2013 EGCG modulated markers of cell cycle (p27/KIP1), angiogenesis (CD31, VEGF, IL-6, IL-8, SEMA3F, and HIF1alpha), and metastasis (MMP2 and MMP7). epigallocatechin gallate 0-4 interleukin 6 Homo sapiens 75-79 26451144-10 2015 In vivo and in vitro studies showed a downregulation of NGAL, IL-17, IL-6, IL-1beta, TNF-alpha, and IFN-gamma after paricalcitol administration (p < 0.0001). paricalcitol 116-128 interleukin 6 Homo sapiens 69-73 23555753-4 2013 Trichostatin A (TSA), an HDAC inhibitor, enhanced lipopolysaccharide (LPS)-induced production of IL-6 in OP9 preadipocytes but not the mature adipocytes. trichostatin A 0-14 interleukin 6 Homo sapiens 97-101 23555753-4 2013 Trichostatin A (TSA), an HDAC inhibitor, enhanced lipopolysaccharide (LPS)-induced production of IL-6 in OP9 preadipocytes but not the mature adipocytes. trichostatin A 16-19 interleukin 6 Homo sapiens 97-101 23555753-5 2013 Moreover, TSA also enhanced palmitic acid-induced IL-6 production and the expression of inflammatory genes induced by LPS in preadipocytes. trichostatin A 10-13 interleukin 6 Homo sapiens 50-54 23734186-12 2013 This increased secretion of TNF-alpha and IL-6 and activation of NF-kB, ERK, and JNK was significantly inhibited by the addition of either mannan or mannose. Mannose 149-156 interleukin 6 Homo sapiens 42-46 23514705-11 2013 Finally, the FLLL32 STAT3 inhibitor abrogated PSC supernatant-mediated MDSC differentiation, PSC viability, and reduced autocrine IL-6 production indicating these processes are STAT3 dependent. FLLL 32 13-19 interleukin 6 Homo sapiens 130-134 25938426-4 2015 The results of MTT assay indicated that HEK 293 cells were more sensitive than HSF to quaternary ammonium pyridoxine derivatives. quaternary ammonium pyridoxine 86-116 interleukin 6 Homo sapiens 79-82 23386688-9 2013 Using pharmacological inhibition of NF-kappaB and inducible knockdown of NF-kappaB p65, we found that JSI-124-induced expression of IL-6, IL-8, and SOCS3 was significantly inhibited, showing an NF-kappaB-dependent mechanism. jsi 102-105 interleukin 6 Homo sapiens 132-136 23467253-3 2013 OBJECTIVES: The aim of the study was to evaluate IL-6 and IL-10 levels in the exhaled breath condensate (EBC) and bronchoalveolar lavage fluid (BALF) of patients with and without pulmonary involvement in SLE. NSC638702 105-108 interleukin 6 Homo sapiens 49-53 25653476-9 2015 Furthermore, rapamycin decreased PA-induced nuclear translocation of NFkappaB P65 subunit, thereby NFkappaB-dependent inflammatory cytokines MCP-1 and IL-6 expression and secretion. Palmitates 33-35 interleukin 6 Homo sapiens 151-155 23089469-11 2012 In conclusion, high therapeutic concentration of prazosin can up-regulate angiogenic IL6 and CCL2 genes in human HCC cells susceptible to amphotericin B-induced oxidative stress. Amphotericin B 138-152 interleukin 6 Homo sapiens 85-88 23349391-7 2013 In a subchronic model of IL-6-induced anemia, NOX-H94 inhibited the decrease in hemoglobin concentration. NOX-H94 46-53 interleukin 6 Homo sapiens 25-29 23186077-7 2012 After paricalcitol treatment, levels of the inflammatory markers CRP, TNF-alpha, IL-6 and IL-18 were significantly reduced in serum and the level of anti-inflammatory cytokine IL-10 was increased. paricalcitol 6-18 interleukin 6 Homo sapiens 81-85 25466658-6 2015 SUA negatively correlated with MIS (r = -0.33; P < 0.001) and interleukin-6 (r = -0.13; P = 0.04). sua 0-3 interleukin 6 Homo sapiens 65-78 23289322-5 2012 L. plantarum NDC 75017 could rapidly activate the phosphorylation of NF-kappaB, and the expressions of il-6 and tlr2 were decreased notably after pretreated with pyrrolidine dithiocarbamate. pyrrolidine dithiocarbamic acid 162-189 interleukin 6 Homo sapiens 103-107 22871212-8 2013 At peak exercise, IL-6 was increased in untreated (DeltaIL-6 = 0.96 +- 0.14) and treated (DeltaIL-6 = 0.91 +- 0.47) patients and controls (DeltaIL-6 = 0.96 +- 0.18); IL-1beta was increased only in controls. deltail 51-58 interleukin 6 Homo sapiens 18-22 22871212-8 2013 At peak exercise, IL-6 was increased in untreated (DeltaIL-6 = 0.96 +- 0.14) and treated (DeltaIL-6 = 0.91 +- 0.47) patients and controls (DeltaIL-6 = 0.96 +- 0.18); IL-1beta was increased only in controls. deltail 90-97 interleukin 6 Homo sapiens 18-22 25466658-9 2015 Associations between SUA and mortality risk continued to be significant after adjustments for various confounders including MIS and interleukin-6. sua 21-24 interleukin 6 Homo sapiens 132-145 25468541-6 2015 RESULTS: Pre-exposure to n-3 PUFAs as individual fatty acids results in reduced placental IL-6 production (P < 0.05), whereas exposure to complex fatty acid mixtures enriched in n-3 PUFAs (high n-3:n-6 ratios) results in a significant stimulation of IL-6 production (P < 0.05). 3 pufas 27-34 interleukin 6 Homo sapiens 90-94 22710762-8 2013 In supernatants, the addition of thalidomide resulted in reduction of TNF-alpha, IL-6, IL-10 and, by trend, IFN-gamma. Thalidomide 33-44 interleukin 6 Homo sapiens 81-85 22577035-9 2012 RESULTS: IgM anti-AC NAb dose-dependently suppressed the production of DNA IC- and RNA IC-induced interleukin-6 and DNA IC-induced tumor necrosis factor alpha, as well as the RNA IC-induced up-regulation of CD86 and CD40 on DCs. nab 21-24 interleukin 6 Homo sapiens 98-111 26179891-0 2015 Effects of diet and/or n-3 fatty acid supplementation on components of the interleukin-6 trans-signalling system in elderly men. Fatty Acids, Omega-3 23-37 interleukin 6 Homo sapiens 75-88 22696070-2 2012 The present study was performed to investigate whether there is any interaction between proteases and phorbol ester in IL-6 release. Phorbol Esters 102-115 interleukin 6 Homo sapiens 119-123 22891040-4 2012 Afatinib activated interleukin-6 receptor (IL-6R)/JAK1/STAT3 signaling via autocrine IL-6 secretion in both cells. Afatinib 0-8 interleukin 6 Homo sapiens 43-47 22732733-8 2013 Time dependence of the production of IL-6 in the primary cell line showed that TfPLL conjugate enabled a gradual release of poly(I:C) and stronger activation of TLR3 receptor in comparison with poly(I:C) alone. poly 124-128 interleukin 6 Homo sapiens 37-41 23818741-5 2013 PI3K/AKT inhibitor LY294002 reversed the effect of tryptase on IL-6 production, whereas inhibitors specific for p38, JNK, and ERK1/2 abolished the effect of tryptase on TNF- alpha production, suggesting that different signaling pathways are involved. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 19-27 interleukin 6 Homo sapiens 63-67 25622744-15 2014 CONCLUSION: Dexmedetomidine preconditioning attenuate remote lung injury of lower limb ischemia-reperfusion, and the mechanism may be related to down-regulation of monocytes TLR4 expression and degradation of IL-6, IL-8 and TNF-alpha level. Dexmedetomidine 12-27 interleukin 6 Homo sapiens 209-213 22677359-6 2013 Lipoxins, resolvins, and protectins derived from various polyunsaturated fatty acids possess anti-inflammatory actions and suppress the production of interleukin-6, and TNF-alpha and VEGF have antiangiogenic actions. Fatty Acids, Unsaturated 57-84 interleukin 6 Homo sapiens 150-163 22105830-9 2012 Both unsaturated fatty acids induced MSC to increase secretion of interleukin-6, VEGF and nitric oxide. Fatty Acids, Unsaturated 5-28 interleukin 6 Homo sapiens 66-79 25384214-6 2014 TANs produced substantial quantities of the proinflammatory factors MCP-1, IL-8, MIP-1alpha, and IL-6, as well as the antiinflammatory IL-1R antagonist. tans 0-4 interleukin 6 Homo sapiens 97-101 23393916-7 2012 IL-6 production in 3T3-L1 adipocytes was markedly increased by CS stimulus, and the enhanced secretion of IL-6 was suppressed in a dose-dependent manner by DTS. Cesium 63-65 interleukin 6 Homo sapiens 0-4 23170847-10 2012 The association between PBM culture secretion of H2O2 and the production of TNF-alpha and IL-6 was not significant. pbm 24-27 interleukin 6 Homo sapiens 90-94 25012594-10 2014 Importantly, we also found that isoflurane pretreatment significantly reduces the production of proinflammatory factors such as tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), IL-beta, and nitric oxide (NO). Isoflurane 32-42 interleukin 6 Homo sapiens 169-182 23257030-8 2012 When the dust doses were 5.0, 10.0, 20.0, and 40.0 microg/ml, the IL-6 releases of nano-SiO2 groups were significantly higher than those of standard quartz groups (P < 0.05); when the dust doses were 20 and 40 microg/ml, the IL-6 releases of nano-TiO2 groups were significantly higher than those of standard quartz groups (P < 0.05). Silicon Dioxide 88-92 interleukin 6 Homo sapiens 66-70 22404905-8 2012 Accordingly, co-treatments combining glucocorticoids with the glucocorticoid antagonist RU-486 or recombinant IL-1alpha efficiently reestablished NF-kappaB transcriptional activity and IL-6 secretion. Mifepristone 88-94 interleukin 6 Homo sapiens 185-189 25012594-10 2014 Importantly, we also found that isoflurane pretreatment significantly reduces the production of proinflammatory factors such as tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), IL-beta, and nitric oxide (NO). Isoflurane 32-42 interleukin 6 Homo sapiens 184-188 22580886-2 2012 Interleukins (IL), such as IL-1beta, IL-6 and IL-10, have various functions in the regulation of the inflammatory response and in proliferative processes after inhalation of silica dust and can, therefore, influence the pathogenesis of asbestos-induced fibrosis and carcinogenesis. Silicon Dioxide 174-180 interleukin 6 Homo sapiens 37-41 22313625-8 2012 It was further demonstrated that treatment with DAE (50 and 100mug/ml) significantly decreased the levels of MMP-2, MMP-9, TNF-alpha, and IL-6. o,p-dinitrophenyl aminoethyldiphosphate-beryllium trifluoride 48-51 interleukin 6 Homo sapiens 138-142 25437592-5 2014 Within 24 hours, 61 and 77% of the IL-6 was released into the peritoneal cavity in the LADG and ODG groups, respectively. BMP15 protein, human 96-99 interleukin 6 Homo sapiens 35-39 25437592-6 2014 In both groups, the concentration and amount of peritoneal fluid IL-6 were significantly correlated with each other (LADG group: Spearman"s rank correlation test [rS] = 0.48, P = 0.04; ODG group: rS = 0.58, P = 0.01). BMP15 protein, human 185-188 interleukin 6 Homo sapiens 65-69 25437592-7 2014 The concentration and amount of IL-6 in peritoneal fluid was 2.8- and 3.6-fold higher in the ODG than in the LADG group, respectively (P < 0.01). BMP15 protein, human 93-96 interleukin 6 Homo sapiens 32-36 22169009-8 2012 Immunohistochemistry showed that calcitriol and paricalcitol reduced MCP-1 and IL-6 in podocytes and tubular cells as well as glomerular infiltration by macrophages, glomerular cell NF-kappaB activation, apoptosis, and extracellular matrix deposition. paricalcitol 48-60 interleukin 6 Homo sapiens 79-83 22015454-8 2012 IC87114, TGX221, and LY294002 reduced TGFbeta1 induced IL-6 release in a dose related manner in all groups of ASM cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 21-29 interleukin 6 Homo sapiens 55-59 25216185-2 2014 To develop novel therapies for CRC, we have explored the effects of a novel small-molecule JAK inhibitor (AZD1480) on IL-6/JAK/STAT3 pathway and its potential antitumor activity on the human CRC cell lines (HCT116, HT29 and SW480). AZD 1480 106-113 interleukin 6 Homo sapiens 118-122 22445541-3 2012 Here, we showed that staphylococcal LTA (Sa.LTA) substantially enhanced IL-6 expression at both the protein and the mRNA levels in the human basophil line, KU812, in the presence of a PKC activator (phorbol 12-myristrate 13-acetate; PMA), and a calcium ionophore (A23187), whereas Sa.LTA alone could not induce IL-6 expression. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 41-43 interleukin 6 Homo sapiens 72-76 22445541-3 2012 Here, we showed that staphylococcal LTA (Sa.LTA) substantially enhanced IL-6 expression at both the protein and the mRNA levels in the human basophil line, KU812, in the presence of a PKC activator (phorbol 12-myristrate 13-acetate; PMA), and a calcium ionophore (A23187), whereas Sa.LTA alone could not induce IL-6 expression. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 41-43 interleukin 6 Homo sapiens 311-315 22169009-9 2012 In cultured podocytes, paricalcitol and calcitriol at concentrations in the physiological and clinically significant range prevented the increase in MCP-1, IL-6, renin, and fibronectin mRNA expression and the secretion of MCP-1 to the culture media induced by high glucose. paricalcitol 23-35 interleukin 6 Homo sapiens 156-160 22313388-0 2012 (-)-Epigallocatechin gallate induces Fas/CD95-mediated apoptosis through inhibiting constitutive and IL-6-induced JAK/STAT3 signaling in head and neck squamous cell carcinoma cells. epigallocatechin gallate 0-28 interleukin 6 Homo sapiens 101-105 22445541-8 2012 Collectively, these results suggest that Sa.LTA exacerbates allergic inflammation by potentiating IL-6 production from activated basophils. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 41-43 interleukin 6 Homo sapiens 98-102 25216185-3 2014 The results showed that, AZD1480 effectively prevents constitutive and IL-6-induced JAK2 and STAT-3 phosphorylation and exerted antitumor functional effects by a decrease in proliferation and an increase in apoptosis in CRC cells. AZD 1480 25-32 interleukin 6 Homo sapiens 71-75 22538414-0 2012 Amphotericin B up-regulates lipid A-induced IL-6 production via caspase-8. Amphotericin B 0-14 interleukin 6 Homo sapiens 44-48 22417709-11 2012 CONCLUSIONS: Our data demonstrate that TLR2 ligation induces the production of IL-23/IL-17 via IL-6, STAT3 and NF-kB pathway in pSS. pss 128-131 interleukin 6 Homo sapiens 95-99 22538414-3 2012 Amphotericin B alone elicited a slight increase in interleukin (IL)-6 and IL-8 production by human gingival fibroblasts. Amphotericin B 0-14 interleukin 6 Homo sapiens 51-69 22538414-4 2012 However, amphotericin B synergistically up-regulated lipid A-induced production of IL-6 and IL-8. Amphotericin B 9-23 interleukin 6 Homo sapiens 83-87 22538414-9 2012 In addition, a caspase-8 inhibitor inhibited IL-6 production by amphotericin B and lipid A. Amphotericin B 64-78 interleukin 6 Homo sapiens 45-49 22538414-10 2012 This suggests that caspase-8 is required for the synergistic production of IL-6 by amphotericin B and lipid A. Amphotericin B 83-97 interleukin 6 Homo sapiens 75-79 25150062-7 2014 HDE-induced IL-6, and IL-8 release was significantly lower in cells that were pretreated with 8-Br-cAMP (P < 0.05). 8-Bromo Cyclic Adenosine Monophosphate 94-103 interleukin 6 Homo sapiens 12-16 21344174-8 2012 Theanine also repressed phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced TNF-alpha, IL-1beta, IL-6, and IL-8 secretion by suppressing NF-kappaB activation. theanine 0-8 interleukin 6 Homo sapiens 114-118 21635200-9 2012 There was significant correlation between baseline maternal IL-6 level and cord blood level in CEA (r = 0.59, p = 0.005), while no significant correlation existed in EEA (r = 0.33, p = 0.16). cea 95-98 interleukin 6 Homo sapiens 60-64 25238263-5 2014 In a 4-NQO-induced esophageal tumor animal model, MDSC recruitment was associated with invasive esophageal tumors and with increased IL-6 levels. 4-Nitroquinoline-1-oxide 5-10 interleukin 6 Homo sapiens 133-137 22010847-3 2012 The objective of this study was to ascertain the effects of AbM intake on serum levels of interleukin-6 (IL-6), interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) in community-living seniors. abm 60-63 interleukin 6 Homo sapiens 90-103 25238263-7 2014 Blockade of IL-6 prevented induction of MDSCs and the incidence of 4-NQO- induced invasive tumors. 4-Nitroquinoline-1-oxide 67-72 interleukin 6 Homo sapiens 12-16 22345573-3 2012 This study examined a role of pathologic CS in modulation of pulmonary EC permeability caused by IL-6, a cytokine increased in sepsis and acting in a Rho-independent manner. Cesium 41-43 interleukin 6 Homo sapiens 97-101 24951586-5 2014 Moreover, treating cells with siRNA to ASM or with the indirect pharmacologic inhibitor desipramine resulted in significant inhibition of TNFalpha- and PMA-induced IL-6 production in MDA-MB-231 and HeLa cells. Desipramine 88-99 interleukin 6 Homo sapiens 164-168 22345573-4 2012 IL-6 increased EC permeability, which was associated with activation of Jak/signal transducers and activators of transcription, p38 MAP kinase, and NF-kappaB signaling and was augmented by EC exposure to 18% CS. Cesium 208-210 interleukin 6 Homo sapiens 0-4 22345573-5 2012 Rho kinase inhibitor Y-27632 suppressed the synergistic effect of 18% CS on IL-6-induced EC monolayer disruption but did not alter the IL-6 effects on static EC culture. Cesium 70-72 interleukin 6 Homo sapiens 76-80 22345573-6 2012 18% CS also increased IL-6-induced ICAM-1 expression by pulmonary EC and neutrophil adhesion, which was attenuated by Y-27632. Cesium 4-6 interleukin 6 Homo sapiens 22-26 21989538-12 2012 Conditioned media from AAT and SM cultures similarly upregulated IL-6, IL-8, Dickkopf-1 and osteoprotegerin production by rheumatoid FLS. o-Aminoazotoluene 23-26 interleukin 6 Homo sapiens 65-69 24773263-6 2014 Dexmedetomidine infusion also suppressed the rise in mean (SD) interleukin-6 levels after cardiopulmonary bypass (a rise of 124.5 (72.0) pg ml(-1) vs. 65.3 (30.9) pg ml(-1)). Dexmedetomidine 0-15 interleukin 6 Homo sapiens 63-76 21347606-11 2012 Dobutamine treatment may contribute to circulating TNF-alpha and dopamine to IL-6, independently of activated neutrophils. Dobutamine 0-10 interleukin 6 Homo sapiens 77-81 22288713-7 2012 Both the NF-kappaB inhibitor, PDTC (pyrrolidine dithiocarbamate) and TLR4 knockdown could block LPS induction of NF-kappaB, STIM, TNFalpha (tumour necrosis factor alpha) and IL-6 (interleukin 6). pyrrolidine dithiocarbamic acid 36-63 interleukin 6 Homo sapiens 174-178 22288713-7 2012 Both the NF-kappaB inhibitor, PDTC (pyrrolidine dithiocarbamate) and TLR4 knockdown could block LPS induction of NF-kappaB, STIM, TNFalpha (tumour necrosis factor alpha) and IL-6 (interleukin 6). pyrrolidine dithiocarbamic acid 36-63 interleukin 6 Homo sapiens 180-193 24867687-5 2014 The NF-kappaB inhibitor DHMEQ inhibited the production of IL-6 and IL-8 by EOC cell lines. dehydroxymethylepoxyquinomicin 24-29 interleukin 6 Homo sapiens 58-62 22377670-3 2012 We have shown that change of stereochemistry at these positions can exert a major influence on antibacterial activity as well as IL-6 inhibition, providing novel macrolide derivatives with diminished antibacterial and potent anti-inflammatory activity. Macrolides 162-171 interleukin 6 Homo sapiens 129-133 22020144-10 2012 We then determined how EGCG affects naive CD4(+) T cell differentiation and found that it impeded Th1 and Th17 differentiation and prevented IL-6-induced inhibition on Treg development. epigallocatechin gallate 23-27 interleukin 6 Homo sapiens 141-145 24913620-8 2014 RESULTS: We demonstrated that CB2 inverse agonists SR144528 and AM630, but not CB2 agonist HU308 or CB1 antagonist SR141716, effectively inhibited IL-6-induced secretion of soluble IgM without affecting cell proliferation as measured by thymidine uptake. Thymidine 237-246 interleukin 6 Homo sapiens 147-151 22186417-9 2012 Cotreatment with LPS and sodium propionate decreased LPS-induced expression of inflammatory genes including IL-6, IL-8, cyclooxygenase-2, IL-1alpha, intercellular adhesion molecule-1, and platelet endothelial cell adhesion molecule-1 but not IL-1beta or lymphocyte function-associated antigen-1. sodium propionate 25-42 interleukin 6 Homo sapiens 108-112 22804935-5 2012 The relative gene expression and protein expression of IL-6 and TNF-alpha enhanced with the reduced concentrations of RU486, which were the lowest when RU486 concentration was 10(-7) mol/L, as compared with control and PQ exposure groups (P < 0.01 or P < 0.05), while the change of IL-10 content was the opposite. Mifepristone 118-123 interleukin 6 Homo sapiens 55-59 24807686-0 2014 Effects of sodium selenite on aflatoxin B1-induced decrease of ileac T cell and the mRNA contents of IL-2, IL-6, and TNF-alpha in broilers. Aflatoxin B1 30-42 interleukin 6 Homo sapiens 107-111 22804935-5 2012 The relative gene expression and protein expression of IL-6 and TNF-alpha enhanced with the reduced concentrations of RU486, which were the lowest when RU486 concentration was 10(-7) mol/L, as compared with control and PQ exposure groups (P < 0.01 or P < 0.05), while the change of IL-10 content was the opposite. Mifepristone 152-157 interleukin 6 Homo sapiens 55-59 22108347-10 2012 CONCLUSION: UA can reduce the over expression of CRP in HepG2 cells induced by IL-6 and inhibit the increased expression of VCAM-1 and LOX-1 in HUVECs caused by CRP. ursolic acid 12-14 interleukin 6 Homo sapiens 79-83 22548119-9 2012 However, there was evidence that sulfotanshinone sodium combined with western medications was a better treatment option than western medications alone in improving clinical symptoms (RR 1.28, 95% CI 1.23 to 1.3), ECG (RR 1.26, 95% CI 1.18 to 1.35), C-reaction protein (mean difference 2.10, 95% CI 1.63 to 2.58), and IL-6 (mean difference -3.85, 95% CI -4.10 to -3.60). tanshinone II A sodium sulfonate 33-55 interleukin 6 Homo sapiens 317-321 24643636-5 2014 Among pro- and anti-inflammatory mediators, only serum ferritin level and IL-10 to IL-6 ratio showed significant changes in favor of omega-3 supplement during the study. Fatty Acids, Omega-3 133-140 interleukin 6 Homo sapiens 83-87 21972215-8 2012 The migration distance of BAEC on PU-Au 43.5 ppm was greater than that of HSF, and was significantly reduced by LY294002 or Y-27632 but not SU-1498. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 112-120 interleukin 6 Homo sapiens 74-77 23183248-6 2012 RESULTS: DETA/NO caused a significant (p < 0.05) increase in IL-6 production. DEET 9-13 interleukin 6 Homo sapiens 64-68 23183248-7 2012 Inhibitors of p38 MAPK and ERK1/2 signaling, but not JNK, were shown to significantly suppress DETA/NO-induced IL-6 production. DEET 95-99 interleukin 6 Homo sapiens 111-115 23183248-8 2012 UPEC-induced IL-6 production was further increased (by 73 +- 23%, p < 0.05) in the presence of DETA/NO. DEET 98-102 interleukin 6 Homo sapiens 13-17 23183248-9 2012 The IL-6 mRNA expression increased 2.1 +- 0.17-fold in response to DETA/NO, while the UPEC-evoked increase was pronounced (20 +- 4.5-fold). DEET 67-71 interleukin 6 Homo sapiens 4-8 23183248-10 2012 A synergistic effect of DETA/NO on UPEC-induced IL-6 expression was found (33 +- 7.2-fold increase). DEET 24-28 interleukin 6 Homo sapiens 48-52 24215203-10 2014 However, the addition of EGCG significantly attenuated the IL-6 expression and NF-kappaB activation. epigallocatechin gallate 25-29 interleukin 6 Homo sapiens 59-63 23183248-11 2012 The IL-6 mRNA stability studies showed that DETA/NO partially attenuated UPEC-induced degradation of IL-6 mRNA. DEET 44-48 interleukin 6 Homo sapiens 4-8 23183248-11 2012 The IL-6 mRNA stability studies showed that DETA/NO partially attenuated UPEC-induced degradation of IL-6 mRNA. DEET 44-48 interleukin 6 Homo sapiens 101-105 22284780-11 2012 Specifically, apiegenin, baicalein, curcumin, EGCG, genistein, luteolin, oridonin, quercetin, and wogonin repress NF-kappaB (NF-kappaB, a proinflammatory transcription factor) and inhibit proinflammatory cytokines such as TNF-alpha and IL-6. epigallocatechin gallate 46-50 interleukin 6 Homo sapiens 236-240 22284780-11 2012 Specifically, apiegenin, baicalein, curcumin, EGCG, genistein, luteolin, oridonin, quercetin, and wogonin repress NF-kappaB (NF-kappaB, a proinflammatory transcription factor) and inhibit proinflammatory cytokines such as TNF-alpha and IL-6. Genistein 52-61 interleukin 6 Homo sapiens 236-240 22736938-13 2012 Treatment with palmitate induced significant production of IL-6 and MCP-1, but not IL-8 and HA, in orbital fibroblasts. Palmitates 15-24 interleukin 6 Homo sapiens 59-63 21664630-7 2011 Visfatin-specific small interfering RNA significantly decreased the palmitate-induced mRNA expression and protein synthesis of interleukin-6 and tumor necrosis factor-alpha. Palmitates 68-77 interleukin 6 Homo sapiens 127-172 24215203-12 2014 CONCLUSION: EGCG could attenuate Pg LPS-enhanced production of MMP-1 in HGFs, whereas this attenuation might be due to the inhibition of IL-6 by EGCG. epigallocatechin gallate 145-149 interleukin 6 Homo sapiens 137-141 22284780-11 2012 Specifically, apiegenin, baicalein, curcumin, EGCG, genistein, luteolin, oridonin, quercetin, and wogonin repress NF-kappaB (NF-kappaB, a proinflammatory transcription factor) and inhibit proinflammatory cytokines such as TNF-alpha and IL-6. oridonin 73-81 interleukin 6 Homo sapiens 236-240 24885771-6 2014 In vitro macrophage exposure to representative NP (Fe2O3, Fe3O4, MnFe2O4 and CrOOH) induced the production of a pro-inflammatory secretome (increased production of CXCL-8, IL-1ss, TNF-alpha, CCL-2, -3, -4, and to a lesser extent IL-6, CCL-7 and -22), and all but Fe3O4 NP induce an increased migration of macrophages (Boyden chamber). crooh 77-82 interleukin 6 Homo sapiens 229-233 22420547-7 2012 A decrease in Il-6 level after application of Cisplatin and Methotrexate and a 5-10 fold increase in the level of Il-6 after application of Etoposide, Carboplatin, Cytarabine, and Gemcitabine were registered in the medium with ganglioneuroblastoma. Etoposide 140-149 interleukin 6 Homo sapiens 114-118 21320636-6 2011 The results showed that the NASH model rats reproduced typical pathogenetic and histopathological features of NASH in human, and genistein administration improved liver function, slowed down NASH progression, decreased the levels of TBARS, TNF-alpha and IL-6 in serum and liver, as well as inhibited IkappaB-alpha phosphorylation, nuclear translocation of NF-kappaB p65 subunit, and activation of c-Jun N-terminal kinase (JNK). Genistein 129-138 interleukin 6 Homo sapiens 254-258 24885636-8 2014 Furthermore, cytokines that were secreted by TAMs, such as IL-6 and IL-8, were also significantly increased. tams 45-49 interleukin 6 Homo sapiens 59-63 21427353-4 2011 When exposed to PAM at 10 microM, NHOK, not NHOF, underwent senescence: NHOK overexpressed senescence-associated beta-galactosidase (SA-beta-Gal), p16INK4A, IL-6, and IL-8. Pamidronate 16-19 interleukin 6 Homo sapiens 157-161 24885636-9 2014 This response was attenuated by treating TAMs with the KCNN4 channel-specific inhibitor, 1-[(2-chlorophenyl) diphenylmethyl]-1H-pyrazole (TRAM-34), which suggested that KCNN4 channels may be involved in inducing the secretion of IL-6 and IL-8 by TAMs and improving CRC cell invasiveness. tams 41-45 interleukin 6 Homo sapiens 229-233 22719178-6 2012 Much data showed that macrolides reduced viral titers of RV ICAM-1, which is the receptor for RV, and RV infection-induced cytokines including IL-1beta, IL-6, IL-8, and TNF-alpha. Macrolides 22-32 interleukin 6 Homo sapiens 153-157 24252030-7 2014 DHMEQ also inhibited expression of IL-1beta, TNFalpha, IL-6 and VCAM-1 by HUVECs. dehydroxymethylepoxyquinomicin 0-5 interleukin 6 Homo sapiens 55-59 22736938-0 2012 Palmitate induced secretion of IL-6 and MCP-1 in orbital fibroblasts derived from patients with thyroid-associated ophthalmopathy. Palmitates 0-9 interleukin 6 Homo sapiens 31-35 23051896-10 2012 The dopamine-induced IL-6 secretion was partially reduced by sulpiride and abrogated by propranolol. Sulpiride 61-70 interleukin 6 Homo sapiens 21-25 23051896-12 2012 The cabergoline-induced IL-6 release was reduced by sulpiride. Sulpiride 52-61 interleukin 6 Homo sapiens 24-28 21291939-5 2011 Proinflammatory cytokine secretion (IL-1beta and IL-6) by the epithelial cells was also regulated by KSL-W in a manner similar to that of antifungal molecule amphotericin B. KSL-W 101-106 interleukin 6 Homo sapiens 49-53 23856970-5 2014 Ambroxol (100 nM) reduced RV14 titers and cytokine concentrations of interleukin (IL)-1beta, IL-6 and IL-8 in the supernatants and RV14 RNA in the cells after RV14 infection, in addition to reducing susceptibility to RV14 infection. Ambroxol 0-8 interleukin 6 Homo sapiens 93-97 20471814-8 2011 GSPE and EGCG also produce all these effects when HepG2 cells are stimulated to import zinc by treatment with supplemental zinc or the proinflammatory cytokine interleukin-6. epigallocatechin gallate 9-13 interleukin 6 Homo sapiens 160-173 21110076-4 2011 Stimulation of PA resulted in IL-6 and TNF-alpha production in HepG2 cells, and antibody-neutralizing assay further confirmed that IL-6 and TNF-alpha were involved in the development of insulin resistance. Palmitates 15-17 interleukin 6 Homo sapiens 30-34 21110076-4 2011 Stimulation of PA resulted in IL-6 and TNF-alpha production in HepG2 cells, and antibody-neutralizing assay further confirmed that IL-6 and TNF-alpha were involved in the development of insulin resistance. Palmitates 15-17 interleukin 6 Homo sapiens 131-135 24370115-1 2014 An Interleukin-6 (IL-6) electrochemical immunosensor was fabricated based on the Au nanoparticles (AuNP)-graphene-silica sol-gel as immobilization biointerface and AuNP-polydopamine (PDA)@carbon nanotubes (CNT) as the label of HRP-bound antibodies. Silicon Dioxide 114-120 interleukin 6 Homo sapiens 18-22 24370115-1 2014 An Interleukin-6 (IL-6) electrochemical immunosensor was fabricated based on the Au nanoparticles (AuNP)-graphene-silica sol-gel as immobilization biointerface and AuNP-polydopamine (PDA)@carbon nanotubes (CNT) as the label of HRP-bound antibodies. 2,3-piperidinedicarboxylic acid 183-186 interleukin 6 Homo sapiens 3-16 24370115-1 2014 An Interleukin-6 (IL-6) electrochemical immunosensor was fabricated based on the Au nanoparticles (AuNP)-graphene-silica sol-gel as immobilization biointerface and AuNP-polydopamine (PDA)@carbon nanotubes (CNT) as the label of HRP-bound antibodies. 2,3-piperidinedicarboxylic acid 183-186 interleukin 6 Homo sapiens 18-22 21683142-4 2011 Anti-inflammatory properties of celastrol were determined by measuring expression levels of IL-6 and endogenous NF-kappaB levels during lipopolysaccharide (LPS) exposure by using enzyme-linked immunosorbent assays (ELISA). celastrol 32-41 interleukin 6 Homo sapiens 92-96 21683142-7 2011 Simultaneous exposures to LPS and celastrol reduced IL-6 expression levels as well as activity of phosphorylated NF-kappaB at serine 536 (Ser536) in ARPE-19 cells when compared to LPS exposure alone. celastrol 34-43 interleukin 6 Homo sapiens 52-56 20671716-3 2011 The objective of this study was to evaluate the effect of optimized synchronized intermittent mandatory ventilation (SIMV) and high-frequency oscillatory ventilation (HFOV) on circulating CC16 and IL-6 levels when used as the initial ventilation modes in preterm neonates. hfov 167-171 interleukin 6 Homo sapiens 197-201 20671716-12 2011 CONCLUSION: In preterm neonates, SIMV and HFOV are associated with comparable circulating CC16 and IL-6 levels. hfov 42-46 interleukin 6 Homo sapiens 99-103 24370115-2 2014 The AuNP-graphene-silica sol-gel film was prepared in situ and modified on the ITO electrode, providing a stable network for the immobilization of antibody and exhibiting a dynamic working range of 1-40 pg/mL with a low detection limit of 0.3 pg/mL IL-6 (at 3s). Silicon Dioxide 18-24 interleukin 6 Homo sapiens 249-253 22190974-2 2011 Various bacterial components, including Toll-like receptor (TLR) ligands and an NKT cell ligand (alpha-galactocylceramide), activate liver Kupffer cells, which produce IL-1, IL-6, IL-12, and TNF. alpha-galactocylceramide 97-121 interleukin 6 Homo sapiens 174-178 21951844-11 2011 Our results also indicated that miRNA-29b-induced apoptosis acted antagonistically with IL-6 in HMCLs. mirna-29b 32-41 interleukin 6 Homo sapiens 88-92 21951844-11 2011 Our results also indicated that miRNA-29b-induced apoptosis acted antagonistically with IL-6 in HMCLs. hmcls 96-101 interleukin 6 Homo sapiens 88-92 24296847-2 2014 We sought to assess whether these MVPA-induced changes in insulin sensitivity are mediated by changes in interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-alpha, and IL-1beta. mvpa 34-38 interleukin 6 Homo sapiens 105-123 21744422-8 2011 RESULTS: ISEMFs of CD patients exhibited an increased oxidative state due to a decrease in the GSH/GSSG ratio, which is related to an increase in basal IL-6 production or is stimulated by tumor necrosis factor alpha (TNFalpha) or bacterial products. Glutathione Disulfide 99-103 interleukin 6 Homo sapiens 152-156 21887376-7 2011 Furthermore, diosquinone caused a decrease in the pro-inflammatory cytokines: tumour necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6). diosquinone 13-24 interleukin 6 Homo sapiens 123-136 21887376-7 2011 Furthermore, diosquinone caused a decrease in the pro-inflammatory cytokines: tumour necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6). diosquinone 13-24 interleukin 6 Homo sapiens 138-142 21511336-3 2011 Thalidomide also promoted a slight increase in IL-6, IL-1beta and TNF-alpha expression in the stromal layers. Thalidomide 0-11 interleukin 6 Homo sapiens 47-51 24664372-5 2014 Knockdown of IL-6 attenuated the anti-proliferative effect of celastrol on PC-3 cells. celastrol 62-71 interleukin 6 Homo sapiens 13-17 21625475-2 2011 We analyzed the association between SUA and circulating levels of interleukin-6 (IL-6), interleukin-1beta (IL-1beta), tumor necrosis factor- alpha (TNF-alpha) and C-reactive protein (CRP). sua 36-39 interleukin 6 Homo sapiens 66-79 24664372-6 2014 Results from ELISA and 5"-deletion transient gene expression assays indicated that celastrol treatment decreased IL-6 secretion and gene expression, and this effect is dependent on the NF-kappaB response element within IL-6 promoter area since mutation of the NF-kappaB response element from AAATGTCCCATTTTCCC to AAATGTTACATTTTCCC by site-directed mutagenesis abolished the inhibition of celastrol on the IL-6 promoter activity. celastrol 83-92 interleukin 6 Homo sapiens 113-117 21625475-7 2011 SUA correlated positively with IL-6, TNF-alpha and CRP and negatively with IL-1beta (Spearman r: 0.04, 0.07, 0.20 and 0.05 in men, and 0.09, 0.13, 0.30 and 0.07 in women, respectively, P<0.05). sua 0-3 interleukin 6 Homo sapiens 31-35 21625475-8 2011 In multivariable analyses, SUA was associated positively with CRP (beta coefficient +- SE = 0.35+-0.02, P<0.001), TNF-alpha (0.08+-0.02, P<0.001) and IL-6 (0.10+-0.03, P<0.001), and negatively with IL-1beta (-0.07+-0.03, P = 0.027). sua 27-30 interleukin 6 Homo sapiens 156-160 24664372-6 2014 Results from ELISA and 5"-deletion transient gene expression assays indicated that celastrol treatment decreased IL-6 secretion and gene expression, and this effect is dependent on the NF-kappaB response element within IL-6 promoter area since mutation of the NF-kappaB response element from AAATGTCCCATTTTCCC to AAATGTTACATTTTCCC by site-directed mutagenesis abolished the inhibition of celastrol on the IL-6 promoter activity. celastrol 83-92 interleukin 6 Homo sapiens 219-223 21625475-10 2011 CONCLUSIONS: SUA was associated positively with IL-6, CRP and TNF-alpha and negatively with IL-1beta, particularly in women. sua 13-16 interleukin 6 Homo sapiens 48-52 21866460-10 2011 When compared with the control group induced by IL-6, EGCG and AG490(a Stat3 pathway inhibitor) significantly inhibited VEGF expression induced by IL-6 (P<0.01). (-)-Epigallocatechin gallate 54-58 interleukin 6 Homo sapiens 147-151 21866460-11 2011 EGCG dose-dependently inhibited pStat3 induced by IL-6(P<0.05), but not tStat3 (P>0.05). (-)-Epigallocatechin gallate 0-4 interleukin 6 Homo sapiens 50-54 24664372-6 2014 Results from ELISA and 5"-deletion transient gene expression assays indicated that celastrol treatment decreased IL-6 secretion and gene expression, and this effect is dependent on the NF-kappaB response element within IL-6 promoter area since mutation of the NF-kappaB response element from AAATGTCCCATTTTCCC to AAATGTTACATTTTCCC by site-directed mutagenesis abolished the inhibition of celastrol on the IL-6 promoter activity. celastrol 83-92 interleukin 6 Homo sapiens 219-223 21866460-12 2011 Stat3 nuclear translocation and Stat3-DNA binding activity in AGS cells or that induced by IL-6 were directly inhibited by EGCG(P<0.05). (-)-Epigallocatechin gallate 123-127 interleukin 6 Homo sapiens 91-95 24664372-6 2014 Results from ELISA and 5"-deletion transient gene expression assays indicated that celastrol treatment decreased IL-6 secretion and gene expression, and this effect is dependent on the NF-kappaB response element within IL-6 promoter area since mutation of the NF-kappaB response element from AAATGTCCCATTTTCCC to AAATGTTACATTTTCCC by site-directed mutagenesis abolished the inhibition of celastrol on the IL-6 promoter activity. celastrol 388-397 interleukin 6 Homo sapiens 219-223 24664372-6 2014 Results from ELISA and 5"-deletion transient gene expression assays indicated that celastrol treatment decreased IL-6 secretion and gene expression, and this effect is dependent on the NF-kappaB response element within IL-6 promoter area since mutation of the NF-kappaB response element from AAATGTCCCATTTTCCC to AAATGTTACATTTTCCC by site-directed mutagenesis abolished the inhibition of celastrol on the IL-6 promoter activity. celastrol 388-397 interleukin 6 Homo sapiens 219-223 24664372-7 2014 Celastrol also attenuated the activation of PMA and TNFalpha on the gene expression and secretion of IL-6 in PC-3 cells. celastrol 0-9 interleukin 6 Homo sapiens 101-105 21515913-5 2011 Blocking the observed constitutive activation of nuclear factor-kappaB (NF-kappaB) with IKK inhibitor wedelolactone in MIA-MSLN cells also reduced IL-6. wedelolactone 102-115 interleukin 6 Homo sapiens 147-151 21251363-11 2011 3 Hydrogen peroxide (H(2)O(2)) and interleukin-6 (IL-6) concentration in exhaled breath condensate (EBC) decreased in both groups but lower in RM group with significant difference [5 days H(2)O(2) (mumol/L): 0.04+-0.02 vs. 0.10+-0.03; IL-6 (ng/L): 4.12+-2.09 vs. 9.26+-3.47, both P<0.05]. NSC638702 100-103 interleukin 6 Homo sapiens 50-54 24664372-8 2014 Immunoblot assays revealed that celastrol treatment downregulated the expressions of IKKalpha, p50 and p65, supporting the 5"-deletion transient gene expression assay result that celastrol blocked IL-6 expression through the NF-kappaB pathway in PC-3 cells. celastrol 32-41 interleukin 6 Homo sapiens 197-201 21209948-6 2010 The pre-translational up-regulation of IL-6 results from increased gene promoter activity and can be reproduced with the PKA agonist, Sp-cAMP and blocked by interrupting the PKA pathway. adenosine-3',5'-cyclic phosphorothioate 134-141 interleukin 6 Homo sapiens 39-43 24664372-8 2014 Immunoblot assays revealed that celastrol treatment downregulated the expressions of IKKalpha, p50 and p65, supporting the 5"-deletion transient gene expression assay result that celastrol blocked IL-6 expression through the NF-kappaB pathway in PC-3 cells. celastrol 179-188 interleukin 6 Homo sapiens 197-201 20816778-9 2010 50% of the control, whereas EGCG provoked a decrease in the IL-6 and IL-8 over-secretion, by 50 and 60%, respectively. epigallocatechin gallate 28-32 interleukin 6 Homo sapiens 60-64 22152249-9 2011 Glycogen synthase kinase-3 beta inhibitor SB216763-pretreatment ameliorated the liver damages significantly as compared to the controls (sALT: 2046+/-513 U/L vs 5809+/-1689 U/L, P = 0.0153), and suppressed the gene expressions of IL-12, TNFa, IL-1b and IL-6. SB 216763 42-50 interleukin 6 Homo sapiens 253-257 24664372-9 2014 For the first time, our results concluded that celastrol attenuates PC-3 cell proliferation via downregulation of IL-6 gene expression through the NF-kappaB-dependent pathway. celastrol 47-56 interleukin 6 Homo sapiens 114-118 24117346-6 2014 In freshly obtained human mononuclear cells 1 mumol/l des-Arg(9)-bradykinin increased expression of the pro-inflammatory factors CXCL5 (CXC chemokine ligand 5) and IL6 (interleukin-6). des-arg 54-61 interleukin 6 Homo sapiens 164-167 21621513-6 2011 Furthermore, pretreatment with casuarinin decreased TNF-alpha-induced pro-inflammatory mediators, such as IL-1beta, IL-6, IL-8, and MCP-1. casuarinin 31-41 interleukin 6 Homo sapiens 116-120 20942805-7 2010 However, breast milk from immigrant women together with LPS induced a lower CBMC release of interleukin (IL)-6 (P = 0 034) and CXCL-8/IL-8 (P = 0 037) compared with breast milk from Swedish women, while breast milk from Swedish women and Mali women tended to increase the response. cbmc 76-80 interleukin 6 Homo sapiens 92-110 21633597-12 2011 EGCG dose-dependently inhibited Stat3 activation induced by IL-6, but did not change the total Stat3 expression. epigallocatechin gallate 0-4 interleukin 6 Homo sapiens 60-64 24117346-6 2014 In freshly obtained human mononuclear cells 1 mumol/l des-Arg(9)-bradykinin increased expression of the pro-inflammatory factors CXCL5 (CXC chemokine ligand 5) and IL6 (interleukin-6). des-arg 54-61 interleukin 6 Homo sapiens 169-182 21633597-13 2011 When treated with EGCG or AG490, VEGF expressions were reduced to the level or an even lower level in the tumor cells not stimulated with IL-6. epigallocatechin gallate 18-22 interleukin 6 Homo sapiens 138-142 21365847-0 2010 [The effects of oxymatrine on expression of interleukin-6 and interleukin-1beta mRNA of human periodontal ligament cell stimulated by lipopolysaccharides]. oxymatrine 16-26 interleukin 6 Homo sapiens 44-57 21365847-1 2010 OBJECTIVE: To observe the effects of oxymatrine on the expression of interleukin-6 (IL-6), interleukin-1beta (IL-1beta) mRNA of human periodontal ligament cell (PDLC) stimulated by lipopolysaccharides (LPS), and to discuss oxymatrine"s inhibition mechanism on periodontal inflammation stimulated by LPS. oxymatrine 37-47 interleukin 6 Homo sapiens 69-82 21633597-16 2011 Furthermore, EGCG inhibited IL-6 induced vascular endothelial cell proliferation and tube formation in vitro and angiogenesis in vitro. epigallocatechin gallate 13-17 interleukin 6 Homo sapiens 28-32 24657910-5 2014 Inhibition of IL-6 or STAT3 using siRNA and/or pharmacological inhibitors reduced IDO mRNA and protein expression as well as kynurenine formation. Kynurenine 125-135 interleukin 6 Homo sapiens 14-18 21633597-17 2011 CONCLUSION: EGCG inhibits IL-6-induced VEGF expression and angiogenesis via suppressing Stat3 activity in gastric cancer, which has provided a novel mechanistic insight into the anti-angiogenic activity of EGCG. epigallocatechin gallate 12-16 interleukin 6 Homo sapiens 26-30 21633597-17 2011 CONCLUSION: EGCG inhibits IL-6-induced VEGF expression and angiogenesis via suppressing Stat3 activity in gastric cancer, which has provided a novel mechanistic insight into the anti-angiogenic activity of EGCG. epigallocatechin gallate 206-210 interleukin 6 Homo sapiens 26-30 21365847-1 2010 OBJECTIVE: To observe the effects of oxymatrine on the expression of interleukin-6 (IL-6), interleukin-1beta (IL-1beta) mRNA of human periodontal ligament cell (PDLC) stimulated by lipopolysaccharides (LPS), and to discuss oxymatrine"s inhibition mechanism on periodontal inflammation stimulated by LPS. oxymatrine 37-47 interleukin 6 Homo sapiens 84-88 21365847-5 2010 CONCLUSION: Oxymatrine can restrain the expression of IL-6 and IL-1beta mRNA of human PDLC stimulated by LPS. oxymatrine 12-22 interleukin 6 Homo sapiens 54-58 20826611-8 2010 Differentiation of monocytes into DCs in the presence of zanamivir results in reduced LPS- induced expression of IL-6, IL-12p40, and TNF-alpha by mature DCs, demonstrating a role for Neu3 in cytokine production. Zanamivir 57-66 interleukin 6 Homo sapiens 113-117 21866484-9 2011 In epilepsy patients studies (including ex vivo) show elevated levels of IL-1 beta, IL-2, IL-5, IL-6 or TNF- alpha after carbamazepine, valproic acid and phenytoin. Carbamazepine 121-134 interleukin 6 Homo sapiens 96-100 24337644-6 2014 15d-PGJ(2) and CV3988 inhibited the LPS-induced mRNA expression and protein production of interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and intercellular adhesion molecule-1 (ICAM-1) in ARPE19 cells. CV 3988 15-21 interleukin 6 Homo sapiens 90-103 21300032-4 2011 Here, we have investigated the molecular basis of the very potent "super"-synergistic IL-6 expression that is apparent after combined treatment of astrocytes with a beta-adrenergic agonist, isoproterenol, and the inflammatory cytokines TNF-alpha and IL-1beta. Isoproterenol 190-203 interleukin 6 Homo sapiens 86-90 21054880-0 2010 Palmitate and insulin synergistically induce IL-6 expression in human monocytes. Palmitates 0-9 interleukin 6 Homo sapiens 45-49 21054880-8 2010 RESULTS: Esterification of palmitate with coenzyme A (CoA) was necessary, while beta-oxidation and ceramide biosynthesis were not required, for the induction of IL-6 and TNF-alpha in THP-1 monocytes. Palmitates 27-36 interleukin 6 Homo sapiens 161-165 21054880-9 2010 Monocytes incubated with insulin and palmitate together produced more IL-6 mRNA and protein, and more TNF-alpha protein, compared to monocytes incubated with palmitate alone. Palmitates 37-46 interleukin 6 Homo sapiens 70-74 24337644-6 2014 15d-PGJ(2) and CV3988 inhibited the LPS-induced mRNA expression and protein production of interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and intercellular adhesion molecule-1 (ICAM-1) in ARPE19 cells. CV 3988 15-21 interleukin 6 Homo sapiens 105-109 21054880-12 2010 MEK/ERK signalling is necessary for synergistic induction of IL-6 by palmitate and insulin. Palmitates 69-78 interleukin 6 Homo sapiens 61-65 24401211-11 2014 Moreover, PUFAs treatment, compared to placebo, decreased IL-6 levels (p = 0.03) and increased PAI-1 levels (p = 0.03). Fatty Acids, Unsaturated 10-15 interleukin 6 Homo sapiens 58-62 20691236-6 2010 The treatment with IndOH-NC markedly inhibited the levels of the pro-inflammatory cytokines IL-1beta, IL-6 and TNF-alpha levels even 48 h after OGD. indoh-nc 19-27 interleukin 6 Homo sapiens 102-106 21166654-2 2011 PI3K inhibitor, LY294002 significantly reduced IL-1beta-induced IL-6 production in A549 cells but not in RASF, indicating that IL-1beta-induced IL-6 production was partially mediated by PI3Kin A549 cells but not in RASF. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 16-24 interleukin 6 Homo sapiens 144-148 24099705-5 2014 Exposing SiO2@LDH nanoparticles to macrophages caused a higher dose-dependent expression of IFN-gamma, IL-6, CD86 and MHC II, compared with SiO2 and LDH respectively. Silicon Dioxide 9-13 interleukin 6 Homo sapiens 103-107 21166654-5 2011 Furthermore, the combination of IRAK4 siRNA and LY294002 treatment decreased protein induction level of IL-6 in A549 cells compared with that of IRAK4 siRNA or LY294002 alone. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 48-56 interleukin 6 Homo sapiens 104-108 21166654-5 2011 Furthermore, the combination of IRAK4 siRNA and LY294002 treatment decreased protein induction level of IL-6 in A549 cells compared with that of IRAK4 siRNA or LY294002 alone. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 160-168 interleukin 6 Homo sapiens 104-108 21418620-9 2011 Plasma IL-6 and IL-1 beta were increased in ICM and decreased in NIDCM, vs controls, respectively.IL-9 levels inversely correlated, in ICM patients, with left ventricular ejection fraction (LVEF) while IL-5 plasma levels inversely correlated with disease duration, in NYHA III/IV ICM patients.This is the first time that both an increase of plasma IL-9, and a decrease of plasma IL-5, IL-7 and IFN-gamma have been reported in ICM as well as in NIDCM groups, vs controls. nidcm 65-70 interleukin 6 Homo sapiens 7-11 20731675-8 2010 All the p38alpha inhibitory drugs inhibited p38alpha phosphorylation and secretion of TNF-alpha, IL-1beta and IL-6 from IBD LPMCs and biopsies. lpmcs 124-129 interleukin 6 Homo sapiens 110-114 20803986-5 2010 RESULTS: Carteolol inhibited production of both TNF-alpha and IL-6 from PBMCs. Carteolol 9-18 interleukin 6 Homo sapiens 62-66 24511210-5 2014 Our results show that five months of paricalcitol administration were associated with a reduction in serum concentrations of hs-CRP (13.9%, P < 0.01), TNF-alpha (11.9%, P = 0.01), and IL-6 (7%, P < 0.05), with a nonsignificant increase of IL-10 by 16%. paricalcitol 37-49 interleukin 6 Homo sapiens 187-191 20309865-8 2010 A synergy between poly(I-C) and IL-17 was observed for the production of IL-6 and CCL20. poly 18-22 interleukin 6 Homo sapiens 73-77 21073547-5 2011 In vitro studies in human lung epithelial cell lines showed that levofloxacin led to a dose-related reduction in IL-6 and IL-8 concentrations, with 300 mug mL(-1) resulting in the reduction of levels of IL-6 by fourfold and IL-8 by twofold (P<0.05); in contrast, tobramycin increased IL-6 levels by 50%, but had no effect on IL-8. Levofloxacin 65-77 interleukin 6 Homo sapiens 113-117 21073547-5 2011 In vitro studies in human lung epithelial cell lines showed that levofloxacin led to a dose-related reduction in IL-6 and IL-8 concentrations, with 300 mug mL(-1) resulting in the reduction of levels of IL-6 by fourfold and IL-8 by twofold (P<0.05); in contrast, tobramycin increased IL-6 levels by 50%, but had no effect on IL-8. Levofloxacin 65-77 interleukin 6 Homo sapiens 203-207 21073547-5 2011 In vitro studies in human lung epithelial cell lines showed that levofloxacin led to a dose-related reduction in IL-6 and IL-8 concentrations, with 300 mug mL(-1) resulting in the reduction of levels of IL-6 by fourfold and IL-8 by twofold (P<0.05); in contrast, tobramycin increased IL-6 levels by 50%, but had no effect on IL-8. Levofloxacin 65-77 interleukin 6 Homo sapiens 203-207 21661448-7 2011 The IL-6 level of drain fluid was significantly higher in the ODG group than the LADG group (p<0.01) on POD1. BMP15 protein, human 62-65 interleukin 6 Homo sapiens 4-8 20461739-2 2010 Epigallocatechin gallate (EGCG) and epicatechin gallate (ECG), the major catechins in green tea, and theaflavin-3,3"-digallate (TFDG), polyphenol in black tea, have multiple beneficial effects, but the effects of catechins and theaflavins on IL-6 production in human gingival fibroblasts (HGFs) are not known. theaflavin-3,3'-digallate 101-126 interleukin 6 Homo sapiens 242-246 24719521-6 2014 Bufalin down regulated the expression levels of nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) during these treatments. bufalin 0-7 interleukin 6 Homo sapiens 134-147 20461739-3 2010 In this study, we investigated the mechanisms by which EGCG, ECG, and TFDG inhibit tumor necrosis factor superfamily 14 (TNFSF14)-induced IL-6 production in HGFs. epigallocatechin gallate 55-59 interleukin 6 Homo sapiens 138-142 20461739-3 2010 In this study, we investigated the mechanisms by which EGCG, ECG, and TFDG inhibit tumor necrosis factor superfamily 14 (TNFSF14)-induced IL-6 production in HGFs. theaflavin-3,3'-digallate 70-74 interleukin 6 Homo sapiens 138-142 20461739-6 2010 EGCG, ECG, and TFDG prevented TNFSF14-mediated IL-6 production in HGFs. epigallocatechin gallate 0-4 interleukin 6 Homo sapiens 47-51 20461739-6 2010 EGCG, ECG, and TFDG prevented TNFSF14-mediated IL-6 production in HGFs. theaflavin-3,3'-digallate 15-19 interleukin 6 Homo sapiens 47-51 20632303-6 2011 Further studies revealed that only oleanolic acid and ursolic acid, but not betulinic acid, could inhibit the lipopolysaccharide induced interleukin-6 release from Mono Mac 6 cells when tested separately. ursolic acid 54-66 interleukin 6 Homo sapiens 137-150 24719521-6 2014 Bufalin down regulated the expression levels of nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) during these treatments. bufalin 0-7 interleukin 6 Homo sapiens 149-153 24255662-12 2013 The levels of TNF-alpha, IL-6, TLR4 and MyD88 were decreased in the dexmedetomidine hydrochloride treatment groups compared with those in the sham control and untreated ischemia reperfusion groups. Dexmedetomidine 68-97 interleukin 6 Homo sapiens 25-29 20833208-8 2011 Significant reduction in IR injury induced iNOS and MMP-9 immunoreactivity, TNFalpha and IL-6 levels and apoptotic DNA fragmentation was also observed with GW1929 treatment. GW 1929 156-162 interleukin 6 Homo sapiens 89-93 20526368-0 2010 Palmitate induced IL-6 and MCP-1 expression in human bladder smooth muscle cells provides a link between diabetes and urinary tract infections. Palmitates 0-9 interleukin 6 Homo sapiens 18-22 20423350-5 2010 KEY RESULTS: Pre-incubation with beta(2)-adrenoceptor agonists (salbutamol, salmeterol, formoterol) augmented the release and mRNA expression of IL-6 and IL-8 induced by IL-1beta and IL-1beta plus histamine, whereas NF-kappaB-dependent transcription was significantly repressed, and AP-1-dependent transcription was unaffected. Albuterol 64-74 interleukin 6 Homo sapiens 145-149 23370294-6 2013 Median serum levels of cytokines IL-1alpha, IL-1beta, IL-1Ra, IL-6 and TNF-alpha in the OSFE group were: 1.077, 1.745, 25.640, 0.602 and 12.768 pg/ml, respectively. osfe 88-92 interleukin 6 Homo sapiens 62-66 20218918-6 2010 Whereas, in the patients with FCF, it was respectively, at 12 h (33.1 pg/mL) and 6 h (17.0 pg/mL), for IL-6 and IL-8 post operatively. 3-[(1e,7e)-8-(2,6-Dioxo-1,2,3,6-Tetrahydropyrimidin-4-Yl)-3,6-Dioxa-2,7-Diazaocta-1,7-Dien-1-Yl]benzoic Acid 30-33 interleukin 6 Homo sapiens 103-107 22018243-7 2011 RESULTS: Peripheral pSS monocytes produced significantly higher amounts of sBAFF and IL-6 than normal monocytes did, even in the absence of stimulation. pss 20-23 interleukin 6 Homo sapiens 85-89 22018243-10 2011 In addition, stimulation of pSS monocytes with sBAFF induced a significant increase in IL-6 production. pss 28-31 interleukin 6 Homo sapiens 87-91 22018243-12 2011 CONCLUSIONS: The results of the present study suggest that the mechanisms underlying the production of sBAFF and IL-6 are impaired in pSS monocytes. pss 134-137 interleukin 6 Homo sapiens 113-117 24070708-7 2013 At concentrations of less than 10 mumol/L, JLU1124 inhibits p38 phosphorylation in a dose-dependent manner and significantly suppresses LPS-induced production of NO, IL-6 and TNF-alpha, and decreases the expressions of iNOS and COX-2 in RAW264.7 macrophages which indicate that JLU1124 has anti-inflammatory effects. JLU1124 43-50 interleukin 6 Homo sapiens 166-170 21422731-6 2011 Inhibition studies using LY294002 (20 microM) revealed the requirement of the PI3K/Akt pathway for LPS-stimulated IL-6 production and NF-kappaB activation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 25-33 interleukin 6 Homo sapiens 114-118 20097190-6 2010 RESULTS: Multi-adjusted regression analyses revealed that plasma n-3 fatty acids were inversely associated with CRP, IL-6 and TNF-alpha; plasma n-6 fatty acids were inversely associated with CRP, IL-6 and fibrinogen; monounsaturated fatty acids were inversely associated with CRP and IL-6 (all p-values<0.05). Fatty Acids, Omega-3 65-80 interleukin 6 Homo sapiens 117-121 20170185-1 2010 In light of the unique ability of thiazolidinediones to mediate peroxisome proliferator-activated receptor (PPAR)gamma-independent activation of adenosine monophosphate-activated protein kinase (AMPK) and suppression of interleukin (IL)-6 production, we conducted a screening of an in-house, thiazolidinedione-based focused compound library to identify novel agents with these dual pharmacological activities. 2,4-thiazolidinedione 34-51 interleukin 6 Homo sapiens 220-238 21430794-1 2011 BACKGROUND: Immune modifications, including changes in interleukin (IL)-6 levels, have often been observed in major depressive disorder (MDD) during treatment with selective serotonin reuptake inhibitors (SSRIs) or the serotonin norepinephrine reuptake inhibitor (SNRI) venlafaxine. serotonin norepinephrine 219-243 interleukin 6 Homo sapiens 55-73 24492341-7 2013 Segregation of antibody and FcRn from endosomes in tubulovesicular transport carriers (TCs) into the recycling pathway can also be observed in live cells, and the extent of IL-6 association with TCs correlates with increasing affinity of the antibody:IL-6 interaction at acidic pH. 9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide 87-90 interleukin 6 Homo sapiens 173-177 21829524-5 2011 Adiponectin significantly increased P4Halpha1 mRNA and protein levels in IL-6-stimulated HASMCs in a dose- and time-dependent manner. hasmcs 89-95 interleukin 6 Homo sapiens 73-77 20022932-6 2010 COX-2 inhibition by NS-398 enhanced IL-6 and TNF-alpha expression and IL-6 protein secretion induced by palmitate. Palmitates 104-113 interleukin 6 Homo sapiens 70-74 24492341-7 2013 Segregation of antibody and FcRn from endosomes in tubulovesicular transport carriers (TCs) into the recycling pathway can also be observed in live cells, and the extent of IL-6 association with TCs correlates with increasing affinity of the antibody:IL-6 interaction at acidic pH. 9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide 87-90 interleukin 6 Homo sapiens 251-255 20410594-1 2010 In the present study, we investigated the effects of a Kampo medicine Orento (TJ-120) on the production of prostaglandin E(2) (PGE(2)), interleukin (IL)-6 and IL-8 by human gingival fibroblasts (HGFs) treated with lipopolysaccharide from Porphyromonas gingivalis (PgLPS). tj-120 78-84 interleukin 6 Homo sapiens 136-154 21829524-6 2011 As well, ERK1/2 and Sp1 played a crucial role in the effect of adiponectin upregulating P4Halpha1 expression in IL-6-stimulated HASMCs. hasmcs 128-134 interleukin 6 Homo sapiens 112-116 24492341-7 2013 Segregation of antibody and FcRn from endosomes in tubulovesicular transport carriers (TCs) into the recycling pathway can also be observed in live cells, and the extent of IL-6 association with TCs correlates with increasing affinity of the antibody:IL-6 interaction at acidic pH. 9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide 195-198 interleukin 6 Homo sapiens 173-177 21355310-0 2011 [Influence of high glucose and mannose binding lectin complement pathway activation to IL-6 and TNF-alpha"s expression by human renal glomerular endothelial cells]. Mannose 31-38 interleukin 6 Homo sapiens 87-91 21355310-1 2011 OBJECTIVE: To investigate the effect of high glucose and mannose binding lectin (MBL) complement pathway activation"s effect on expression of Interleukin-6 (IL-6) and Tumor necrosis factor-alpha (TNF-alpha) from human renal glomerular endothelial cells (HRGEC), to explore unknown pathogenesy of diabetic nephropathy. Mannose 57-64 interleukin 6 Homo sapiens 142-155 24001805-6 2013 It was found that nano-SiO2 exposure decreased cell survival rate, increased LDH leakage, TNF-alpha and IL-6 production. Silicon Dioxide 23-27 interleukin 6 Homo sapiens 104-108 21355310-1 2011 OBJECTIVE: To investigate the effect of high glucose and mannose binding lectin (MBL) complement pathway activation"s effect on expression of Interleukin-6 (IL-6) and Tumor necrosis factor-alpha (TNF-alpha) from human renal glomerular endothelial cells (HRGEC), to explore unknown pathogenesy of diabetic nephropathy. Mannose 57-64 interleukin 6 Homo sapiens 157-161 21169142-11 2010 Release of C3a was attenuated in the fenoldopam group (P = .002), and release of IL-6 and IL-8 was attenuated in the postoperative period in the fenoldopam group (P = .012 and .015, respectively). Fenoldopam 145-155 interleukin 6 Homo sapiens 81-85 20184800-9 2010 Moreover, AG-1478 (2 microM), reduced BK-induced IL-6 secretion by 28% and abrogated the synergic induction of IL-6 induced by BK plus EGF (from 8312 +/- 1267 to 3229 +/- 597 pg/ml, n = 5, p < 0.05). RTKI cpd 10-17 interleukin 6 Homo sapiens 49-53 20184800-9 2010 Moreover, AG-1478 (2 microM), reduced BK-induced IL-6 secretion by 28% and abrogated the synergic induction of IL-6 induced by BK plus EGF (from 8312 +/- 1267 to 3229 +/- 597 pg/ml, n = 5, p < 0.05). RTKI cpd 10-17 interleukin 6 Homo sapiens 111-115 20184800-10 2010 AG-1478 dual effects on IL-6 secretion induced by BK alone or BK plus EGF were also observed in cells treated with genistein, a tyrosine kinase inhibitor, and AG-825, an ErbB-2 inhibitor. RTKI cpd 0-7 interleukin 6 Homo sapiens 24-28 20184800-10 2010 AG-1478 dual effects on IL-6 secretion induced by BK alone or BK plus EGF were also observed in cells treated with genistein, a tyrosine kinase inhibitor, and AG-825, an ErbB-2 inhibitor. Genistein 115-124 interleukin 6 Homo sapiens 24-28 24001805-8 2013 Furthermore, potassium channel blockers tetraethylammonium (TEA), 4-amino pyridine (4-AP), and margatoxin (MGTX) reduced the nano-SiO2-induced cytotoxity and inflammation, i.e., increase in the cell survival rate, and decrease in the LDH leakage and production of TNF-alpha and IL-6. Silicon Dioxide 130-134 interleukin 6 Homo sapiens 278-282 23793449-6 2013 RESULTS: The pro-inflammatory cytokine IL-6 was increased in the isoflurane group at T2 and T3 compared to T1 (P < 0.01). Isoflurane 65-75 interleukin 6 Homo sapiens 39-43 20839488-11 2010 The IL-6 high-expression genotype was associated with an increased likelihood of > or =3 URS episodes in a 12 month period (odds ratio (OR): 2.87, 95% confidence interval (CI): 1.10-7.53; p = 0.03). Peptichemio 92-95 interleukin 6 Homo sapiens 4-8 22084588-8 2010 KYN/TRP correlated with neopterin (p < 0.001) and also with TNF-alpha (p < 0.01) and IL-6 concentrations (p < 0.05) and inversely with the in vitro response of stimulated monocytes. Kynurenine 0-3 interleukin 6 Homo sapiens 91-95 20738764-10 2010 CONCLUSION: These results indicate that aggretin may induce cytokine TNF-alpha/IL-6 release via interacting with CLEC-2 receptor and the subsequent MAPK and NF-kappaB activation in monocytes/macrophages. aggretin 40-48 interleukin 6 Homo sapiens 79-83 20818158-0 2010 IL-6, a risk factor for hepatocellular carcinoma: FLLL32 inhibits IL-6-induced STAT3 phosphorylation in human hepatocellular cancer cells. FLLL 32 50-56 interleukin 6 Homo sapiens 0-4 20818158-0 2010 IL-6, a risk factor for hepatocellular carcinoma: FLLL32 inhibits IL-6-induced STAT3 phosphorylation in human hepatocellular cancer cells. FLLL 32 50-56 interleukin 6 Homo sapiens 66-70 19622106-5 2009 MIBG washout and MIBG H/M ratio had a significant correlation with IL-6 (r = 0.42, P<0.001 and r = -0.31, P<0.01) and NT-proBNP (r = 0.48, P<0.001 and r = -0.40, P<0.001). 3-Iodobenzylguanidine 0-4 interleukin 6 Homo sapiens 67-71 20818158-7 2010 Here we summarized the recent studies of IL-6 in HCC and showed another STAT3 small-molecule inhibitor FLLL32 also blocked IL-6-induced STAT3 activation in HCC cells. FLLL 32 103-109 interleukin 6 Homo sapiens 41-45 23833248-5 2013 Palmitate, but not palmitoleate, induced phosphorylation/activation of the MEK-ERK-IKK axis and proinflammatory cytokine (IL-6, CINC-1) expression. Palmitates 0-9 interleukin 6 Homo sapiens 122-126 20818158-7 2010 Here we summarized the recent studies of IL-6 in HCC and showed another STAT3 small-molecule inhibitor FLLL32 also blocked IL-6-induced STAT3 activation in HCC cells. FLLL 32 103-109 interleukin 6 Homo sapiens 123-127 20818158-9 2010 We demonstrated that FLLL32 blocked IL-6-induced STAT3 phosphorylation and nuclear translocation. FLLL 32 21-27 interleukin 6 Homo sapiens 36-40 20573419-4 2010 TSA inhibited the production of IFN-I, TRAIL and of the pro-inflammatory cytokines TNFalpha and IL-6 by CpG-activated PDC. trichostatin A 0-3 interleukin 6 Homo sapiens 96-100 19622106-5 2009 MIBG washout and MIBG H/M ratio had a significant correlation with IL-6 (r = 0.42, P<0.001 and r = -0.31, P<0.01) and NT-proBNP (r = 0.48, P<0.001 and r = -0.40, P<0.001). 3-Iodobenzylguanidine 17-21 interleukin 6 Homo sapiens 67-71 19759245-10 2009 Moreover, the secretion of inflammatory molecules (interleukin-6 and monocyte chemoattractant protein-1) induced by macrophage-secreted factors was partially abolished in 100 micromol/L 1,2-DT-treated preadipocytes (-28 and -25%, respectively). 1,2-dt 186-192 interleukin 6 Homo sapiens 51-64 23136947-6 2013 Similarly, IL-6 upregulation was partially prevented by siMyD88 or siTRAM in HGF stimulated with Pg LPS, as well as in both fibroblast subtypes challenged with Pam2CSK4. simyd88 56-63 interleukin 6 Homo sapiens 11-15 19607809-3 2009 Both OA-NO(2) and LNO(2) prevented TNFalpha-stimulated release of the cytokines, IL-6, IL-8, IL-12/p40, IFNgamma, MCP-1, and IP-10, and inhibited NF-kappaB activation. L-Leucyl-Hydroxylamine 18-21 interleukin 6 Homo sapiens 81-85 20573582-7 2010 DHMEQ significantly inhibited DC production of proinflammatory cytokines (IL-6, TNF-alpha, and IL-12 p70) in a dose-dependent manner. dehydroxymethylepoxyquinomicin 0-5 interleukin 6 Homo sapiens 74-78 20388727-8 2010 It is noteworthy that when the drugs were used in combination the effects of theophylline and salbutamol were additive in inhibiting TNF-alpha release, but theophylline blocked the IL-6-enhancing effect of salbutamol. Albuterol 206-216 interleukin 6 Homo sapiens 181-185 23946637-9 2013 The PBMCs of the patients with wet AMD produced more IL-6 and IL-8 proteins than the controls in response to PGN, a ligand for TLR2, and more IL-6 protein than the controls in response to poly(I:C), the ligand for TLR3. poly 188-192 interleukin 6 Homo sapiens 142-146 19844976-6 2010 Furthermore, cobalt, molybdenum ions, and Co-Cr-Mo alloy particles similarly induce elevated secretion of IL-1beta, TNFalpha, and IL-6. Cobalt 13-19 interleukin 6 Homo sapiens 130-134 20526368-9 2010 Palmitate upregulates IL-6 mRNA expression and secretion via NF-kappaB dependent pathways in a concentration- and time-dependent manner. Palmitates 0-9 interleukin 6 Homo sapiens 22-26 20526368-11 2010 Soluble IL-6 receptor (gp80soluble) was downregulated by palmitate and LPS, while membrane-bound gp80 was moderately upregulated. Palmitates 57-66 interleukin 6 Homo sapiens 8-12 20526368-14 2010 CONCLUSIONS/SIGNIFICANCE: Bacterial infection (LPS) or metabolic alterations (palmitate) have distinct effects on IL-6 expression in hBSMC, (i) short term LPS induced autocrine JAK/STAT signaling and (ii) long-term endocrine regulation of IL-6 by palmitate. Palmitates 78-87 interleukin 6 Homo sapiens 114-118 19580863-9 2009 Our findings suggest that silica-induced IL-6 release from pneumocytes is mainly mediated via IL-1 beta release from the monocytes, via both COX2-dependent and -independent pathways. Silicon Dioxide 26-32 interleukin 6 Homo sapiens 41-45 19580863-11 2009 In contrast to silica-induced IL-6, the reduction in pneumocyte loss by IL-1 beta does not seem to be regulated through an IL-1R1-dependent mechanism. Silicon Dioxide 15-21 interleukin 6 Homo sapiens 30-34 20526368-14 2010 CONCLUSIONS/SIGNIFICANCE: Bacterial infection (LPS) or metabolic alterations (palmitate) have distinct effects on IL-6 expression in hBSMC, (i) short term LPS induced autocrine JAK/STAT signaling and (ii) long-term endocrine regulation of IL-6 by palmitate. Palmitates 78-87 interleukin 6 Homo sapiens 239-243 23720457-9 2013 Ambrisentan blocked M-LPS-induced IL-6 release but not IL-8, GM-CSF, or LPS receptors. ambrisentan blocked m-lps 0-25 interleukin 6 Homo sapiens 34-38 20184875-4 2010 Anti-IL-6 receptor antibody significantly (but only partially) suppressed T cell activation (as indicated by [3H]-thymidine uptake and CD25 expression) and IL-2 production in both systems, and increased the frequency of regulatory T cells among spleen cells. Thymidine 114-123 interleukin 6 Homo sapiens 5-9 23706224-1 2013 Chitosan-silica/CpG oligodeoxynucleotide (ODN) nanohybrids were synthesized to stimulate Toll-like receptor 9-mediated induction of interleukin-6 (IL-6). Silicon Dioxide 9-15 interleukin 6 Homo sapiens 132-145 20194598-7 2010 We observed that epithelial production of interleukin-8 (IL-8) and IL-6 in response to bacterial stimulation was significantly inhibited in the presence of CS (P < 0.001 for inhibition by either CSC or CSE). Cesium 156-158 interleukin 6 Homo sapiens 67-71 19349390-8 2009 Exposure to 4 h of hypoxia led to an about twofold increase in IL-6 messenger RNA in cultured human PA-SMCs. pa-smcs 100-107 interleukin 6 Homo sapiens 63-67 23706224-1 2013 Chitosan-silica/CpG oligodeoxynucleotide (ODN) nanohybrids were synthesized to stimulate Toll-like receptor 9-mediated induction of interleukin-6 (IL-6). Silicon Dioxide 9-15 interleukin 6 Homo sapiens 147-151 19651324-12 2009 Additionally, SM upregulates many inflammatory mediators including interleukin (IL)-1alpha, IL-1beta, IL-6, IL-8, tumor necrosis factor-alpha (TNF-alpha) and others. Mustard Gas 14-16 interleukin 6 Homo sapiens 102-106 20044439-10 2010 The present study profiles the regulatory relationship between LPA and multiple cytokines in vascular SMCs for the first time, provides the first evidence that LPA upregulates IL-6 in vascular SMCs, and reveals the regulatory mechanism of LPA-induced IL-6 production in HASMCs. hasmcs 270-276 interleukin 6 Homo sapiens 251-255 23706224-1 2013 Chitosan-silica/CpG oligodeoxynucleotide (ODN) nanohybrids were synthesized to stimulate Toll-like receptor 9-mediated induction of interleukin-6 (IL-6). Oligodeoxyribonucleotides 20-40 interleukin 6 Homo sapiens 132-145 23706224-1 2013 Chitosan-silica/CpG oligodeoxynucleotide (ODN) nanohybrids were synthesized to stimulate Toll-like receptor 9-mediated induction of interleukin-6 (IL-6). Oligodeoxyribonucleotides 20-40 interleukin 6 Homo sapiens 147-151 19503017-3 2009 In addition, albuterol, a commonly prescribed asthma therapy, has been shown to influence IL6 gene expression. Albuterol 13-22 interleukin 6 Homo sapiens 90-93 23706224-1 2013 Chitosan-silica/CpG oligodeoxynucleotide (ODN) nanohybrids were synthesized to stimulate Toll-like receptor 9-mediated induction of interleukin-6 (IL-6). Oligodeoxyribonucleotides 42-45 interleukin 6 Homo sapiens 132-145 19503017-4 2009 Therefore, we reasoned that interactions between the IL6 and IL6R genes might be associated with bronchodilator drug responsiveness to albuterol in asthmatic patients. Albuterol 135-144 interleukin 6 Homo sapiens 53-56 19850944-6 2010 Modulation by norepinephrine and salbutamol of IL-6 production by stimulated in vitro lymphoblastoid cells was measured by genotype. Albuterol 33-43 interleukin 6 Homo sapiens 47-51 19850944-11 2010 The AA genotype was associated with decreased norepinephrine and salbutamol inhibition of IL-6 production by stimulated lymphoblastoid cells in vitro (P < 0.05). Albuterol 65-75 interleukin 6 Homo sapiens 90-94 23706224-1 2013 Chitosan-silica/CpG oligodeoxynucleotide (ODN) nanohybrids were synthesized to stimulate Toll-like receptor 9-mediated induction of interleukin-6 (IL-6). Oligodeoxyribonucleotides 42-45 interleukin 6 Homo sapiens 147-151 23706224-8 2013 Chitosan-silica/CpG ODN nanohybrids underwent cellular uptake and enhanced induction of IL-6 to a greater degree than conventional chitosan/CpG ODN nanocomplexes, indicating that they have an enhanced delivery efficiency. Silicon Dioxide 9-15 interleukin 6 Homo sapiens 88-92 19914334-8 2010 We found a di-nucleotide haplotype block and a tri-nucleotide haplotype block in the genes of IL-6 and IL-6R, respectively. Dinucleoside Phosphates 11-24 interleukin 6 Homo sapiens 94-98 19384869-5 2009 Stimulation of BM CD20(+) B cells by CpG-containing oligodeoxynucleotide-enhanced expression of activation markers (CD86 and CD54) triggered IL-6 and TNF-alpha secretion and cell proliferation. Oligodeoxyribonucleotides 52-72 interleukin 6 Homo sapiens 141-145 23791833-9 2013 An AKT inhibitor LY294002 effectively suppressed IKK/IkappaB/NF-kappaB signaling and PON1 gene expression induced by IL-6. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 17-25 interleukin 6 Homo sapiens 117-121 19103478-9 2009 We suggest that HM can modulate the inflammatory response by inducing IL-8 and IL-6 production via TLR4-dependent activation of the NF-kappaB signaling pathway. His-Met 16-18 interleukin 6 Homo sapiens 79-83 21147711-0 2010 Association of interleukin-6 gene -572 C > G polymorphism with dietary intake of n-3 fatty acids on plasma HDL-c level in Chinese male adults. Fatty Acids, Omega-3 84-99 interleukin 6 Homo sapiens 15-28 24284039-0 2013 Thalidomide distinctly affected TNF-alpha, IL-6 and MMP secretion by an ovarian cancer cell line (SKOV-3) and primary ovarian cancer cells. Thalidomide 0-11 interleukin 6 Homo sapiens 43-47 19660753-7 2010 The risk associated with low retinol was comparable to strong risk factors (e.g. HDL-cholesterol, Interleukin-6) and behaved additively. Vitamin A 29-36 interleukin 6 Homo sapiens 98-111 19681908-7 2009 In addition, interleukin-6 production by human dendritic cells was enhanced by C. jejuni lacking N-linked glycans compared with wild-type bacteria. n-linked glycans 97-113 interleukin 6 Homo sapiens 13-26 19336930-3 2009 Although (+/-)-3-methoxynordomesticine possesses weak antimicrobial activity, it inhibits the production of nitric oxide (NO), prostaglandin (PG)E(2), tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta and IL-6 and the expression of inducible nitric oxide synthase (iNOS) and cycloxygenase (COX)-2 in macrophages stimulated with LPS in vitro. (+/-)-3-methoxynordomesticine 9-38 interleukin 6 Homo sapiens 214-218 19103760-3 2009 We found that this chalcone inhibited both constitutive and interleukin-6-inducible STAT3 activation in multiple myeloma (MM) cells. Chalcone 19-27 interleukin 6 Homo sapiens 60-73 24284039-2 2013 The aim of this study was to evaluate the effect of thalidomide on TNF-alpha, IL-6 and MMP secretion in epithelial ovarian carcinoma cells. Thalidomide 52-63 interleukin 6 Homo sapiens 78-82 24284039-10 2013 CONCLUSION: Our study suggests that thalidomide distinctly affected TNF-alpha, IL-6 and MMPs secretion by an ovarian carcinoma cell line (SKOV-3) and primary ovarian cancer cells. Thalidomide 36-47 interleukin 6 Homo sapiens 79-83 23741300-7 2013 On day 7, CDDO-Me reduced total BALF protein by 50%, alveolar macrophage infiltration by 40%, neutrophil infiltration by 90% (p<=0.01), inhibited production of the inflammatory cytokines KC and IL-6 by over 90% (p<=0.001), and excess production of the pro-fibrotic cytokine TGFbeta by 50%. bardoxolone methyl 10-17 interleukin 6 Homo sapiens 197-201 19567096-4 2009 RESULTS: The serum MIF, TNF-alpha, and IL-6 levels of the DM, DPN, and DPNP groups were all significantly higher than those of the control group (P < 0. dpn 62-65 interleukin 6 Homo sapiens 39-43 19567096-9 2009 CONCLUSIONS: The serum pro-inflammatory cytokines MIF, TNF-alpha, and IL-6 levels play an important role in the pathogenesis of DM and DPN, but may not play an important role in the development of DPNP. dpn 135-138 interleukin 6 Homo sapiens 70-74 19748599-0 2009 Serum levels of IL-8 and IL-6 in the long term pulmonary complications induced by sulfur mustard: Sardasht-Iran Cohort Study. Mustard Gas 82-96 interleukin 6 Homo sapiens 25-29 24472144-6 2013 RESULTS: The only statistically significant difference in area-under-the-curve concentrations was for IL-6, which was greater in patients given isoflurane:78 (95% confidence interval (CI): 52 to 109) pg/ml versus 33 (22 to 50) pg/ml, P= 0.006. Isoflurane 144-154 interleukin 6 Homo sapiens 102-106 19625064-2 2009 Fasting concentrations of interleukin-6 (IL-6) and C-reactive protein (CRP), key inflammatory mediators, decrease after sustained n-3 polyunsaturated fatty acid (PUFA) intake; however, the ability of n-3 PUFA to attenuate postprandial inflammatory responses is not well studied. Fatty Acids, Omega-3 130-160 interleukin 6 Homo sapiens 26-39 19625064-2 2009 Fasting concentrations of interleukin-6 (IL-6) and C-reactive protein (CRP), key inflammatory mediators, decrease after sustained n-3 polyunsaturated fatty acid (PUFA) intake; however, the ability of n-3 PUFA to attenuate postprandial inflammatory responses is not well studied. Fatty Acids, Unsaturated 162-166 interleukin 6 Homo sapiens 26-39 19625064-2 2009 Fasting concentrations of interleukin-6 (IL-6) and C-reactive protein (CRP), key inflammatory mediators, decrease after sustained n-3 polyunsaturated fatty acid (PUFA) intake; however, the ability of n-3 PUFA to attenuate postprandial inflammatory responses is not well studied. Fatty Acids, Unsaturated 162-166 interleukin 6 Homo sapiens 41-45 19135236-9 2009 BAFF levels were also significantly correlated with the other B cell-activating cytokines IL-6 (r = 0.875, P < .001) and IL-13 (r = 0.812, P < .001). baff 0-4 interleukin 6 Homo sapiens 90-94 19690405-9 2009 In stepwise multiple regression analyses, age, phosphorus and high-sensitivity C-reactive protein were independent predictors of IL-6 (R(2) = 0.466, p < 0.0001). Phosphorus 47-57 interleukin 6 Homo sapiens 129-133 19675564-2 2009 Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion. Phosphatidylcholines 93-112 interleukin 6 Homo sapiens 215-218 24472144-7 2013 Two hours after surgery, IL-6 was significantly greater than baseline in patients assigned to isoflurane: 47 (95% CI: 4 to 216, P<0.001) pg/ml versus 18 (95%CI: 4 to 374, P<0.001) pg/ml in the TIVA group. Isoflurane 94-104 interleukin 6 Homo sapiens 25-29 24472144-11 2013 Two hours after surgery, IL-6 concentrations were significantly greater in patients given isoflurane than TIVA. Isoflurane 90-100 interleukin 6 Homo sapiens 25-29 19606255-6 2009 A significant increase of IL-6, IL-12, IFN-gamma and TNF-alpha was observed in the HI group after treatment with FR-91. fr-91 113-118 interleukin 6 Homo sapiens 26-30 24472144-11 2013 Two hours after surgery, IL-6 concentrations were significantly greater in patients given isoflurane than TIVA. tiva 106-110 interleukin 6 Homo sapiens 25-29 19164258-12 2009 Retinol concentrations decreased with PD therapy and were inversely related to interleukin-6 and CRP concentrations. Vitamin A 0-7 interleukin 6 Homo sapiens 79-92 19833744-5 2009 In patients with pSS SAA concentrations correlated significantly with age, leukocyte count, CRP, interleukin 6, and C4. pss 17-20 interleukin 6 Homo sapiens 97-110 23488631-5 2013 A significant, more than 50% mean inhibition of PMA/I-induced IL-6 and IL-8 release was demonstrated for the volatile compounds 1,8-cineole, borneol, camphor, and thujone, but not for the nonvolatile rosmarinic acid when applied in concentrations representative of sage infusion. beta-thujone 163-170 interleukin 6 Homo sapiens 62-66 23481185-5 2013 RESULTS: Mono-methyl XAA analogues with substitutions at the seventh and eighth positions were the most active in stimulating human leukocytes to produce IL-6 and IL-8; and for inhibition of tube formation by ECV304 human endothelial-like cells, while 5- and 6-substituted analogues were the most active in murine cell systems. mono-methyl xaa 9-24 interleukin 6 Homo sapiens 154-158 19350266-6 2009 Meanwhile, the levels of IL6 on days 1 and 3 were markedly lower in the Verapamil group than that in control group (P < 0.05 and P < 0.01, respectively. Verapamil 72-81 interleukin 6 Homo sapiens 25-28 19619183-8 2009 Patients with atherosclerosis in the DM group had significantly higher serum concentrations of interleukin-6 than the ones in the non-DM group: 11 (6-24) versus 5 (2-9) pg/mL, respectively (P = 0.002). dm 37-39 interleukin 6 Homo sapiens 95-108 19619183-8 2009 Patients with atherosclerosis in the DM group had significantly higher serum concentrations of interleukin-6 than the ones in the non-DM group: 11 (6-24) versus 5 (2-9) pg/mL, respectively (P = 0.002). dm 134-136 interleukin 6 Homo sapiens 95-108 18936832-1 2008 We report a dye-encapsulated silica nanoparticle as a label, with the advantages of high fluorescence intensity, photostability, and biocompatibility, in conjunction with microarray technology for sensitive immunoassay of a biomarker, interleukin-6 (IL-6), on a microarray format. Silicon Dioxide 29-35 interleukin 6 Homo sapiens 235-248 18936832-1 2008 We report a dye-encapsulated silica nanoparticle as a label, with the advantages of high fluorescence intensity, photostability, and biocompatibility, in conjunction with microarray technology for sensitive immunoassay of a biomarker, interleukin-6 (IL-6), on a microarray format. Silicon Dioxide 29-35 interleukin 6 Homo sapiens 250-254 18936832-5 2008 The microarray fluorescent immunoassay approach based on dye-doped silica nanoparticle labels has high sensitivity for practical applications with a limit of detection for IL-6 down to 0.1 ng mL(-1). Silicon Dioxide 67-73 interleukin 6 Homo sapiens 172-176 18785949-10 2008 Pyridostigmine stimulated the release of IL-6 and GH, but not IL-8 or IL-10; these responses were significantly augmented in IBS patients relative to controls. Pyridostigmine Bromide 0-14 interleukin 6 Homo sapiens 41-52 23780308-4 2013 EGCG inhibited high glucose(HG)-induced TNF-alpha and IL-6 production in human embryonic kidney (HEK) cells. epigallocatechin gallate 0-4 interleukin 6 Homo sapiens 54-58 18785949-11 2008 The IL-6 level following pyridostigmine administration correlated significantly with the symptom score (P < 0.01). Pyridostigmine Bromide 25-39 interleukin 6 Homo sapiens 4-8 18785949-12 2008 In study 2, IL-6 rose following pyridostigmine in IBS but not depression and procyclidine blocked the rise. Pyridostigmine Bromide 32-46 interleukin 6 Homo sapiens 12-16 19185299-5 2009 RESULTS: After multivariable adjustment, n-3 fatty acid levels (DHA+EPA) were inversely associated with CRP and IL-6. Fatty Acids, Omega-3 41-55 interleukin 6 Homo sapiens 112-116 19185299-6 2009 The inverse association of n-3 fatty acids with CRP and IL-6 was not modified by demographics, body-mass index, smoking, LDL-cholesterol, or statin use (p values for interaction>0.1). Fatty Acids, Omega-3 27-42 interleukin 6 Homo sapiens 56-60 18633101-12 2008 Palmitate also increased IL-6 and SOD2 gene expression, and this effect was prevented by inhibiting NFkappaB. Palmitates 0-9 interleukin 6 Homo sapiens 25-29 23478407-6 2013 Additionally, rapa-ECs produced lower levels of the inflammatory cytokine IL-6. rapa-ecs 14-22 interleukin 6 Homo sapiens 74-78 19967068-2 2008 In the present study, we found that specific tyrphostin inhibitors of ErbB2 (AG825 and AG879), but not ErbB1 inhibitor (AG1478), suppressed IL-6-induced tyrosine phosphorylation of STAT3 in schwannoma cells. AG-879 87-92 interleukin 6 Homo sapiens 140-144 19640331-1 2009 PURPOSE: The primary aim of the study was to investigate the effect of sinvastatin on plasma interleukin-6 (IL-6) in patients with unstable angina pectoris (UAP). sinvastatin 71-82 interleukin 6 Homo sapiens 93-106 19640331-1 2009 PURPOSE: The primary aim of the study was to investigate the effect of sinvastatin on plasma interleukin-6 (IL-6) in patients with unstable angina pectoris (UAP). sinvastatin 71-82 interleukin 6 Homo sapiens 108-112 23331611-7 2013 The incubation of peritoneal M-DM in the presence of LPS and C. albicans increased the release of IL-6, TNF-alpha and IL-10. dm 31-33 interleukin 6 Homo sapiens 98-102 19514122-10 2009 While increased expressions of the IL-6 receptor, phosphorylated MAPK, and Akt were observed after exposure to GC, TM411 attenuated this increase in the expressions, suggesting that such modification of the effect of GC by TM411 might be the possible mechanism underlying the synergistic interaction. tamibarotene 223-228 interleukin 6 Homo sapiens 35-39 18657656-0 2008 Additive prognostic value of interleukin-6 at peak phase of dobutamine stress echocardiography in patients with coronary artery disease. Dobutamine 60-70 interleukin 6 Homo sapiens 29-42 18657656-2 2008 BACKGROUND: Interleukin-6 (IL-6) and tissue factor (TF) are elevated after myocardial ischemia during dobutamine stress echo (DSE). Dobutamine 102-112 interleukin 6 Homo sapiens 12-25 18657656-2 2008 BACKGROUND: Interleukin-6 (IL-6) and tissue factor (TF) are elevated after myocardial ischemia during dobutamine stress echo (DSE). Dobutamine 102-112 interleukin 6 Homo sapiens 27-31 19101597-6 2009 In contrast, relaxin and modified relaxin inhibited endotoxin-stimulated secretion of TNF-alpha and IL-6 by human macrophages, an effect sensitive to the glucocorticoid receptor antagonists RU-486 and D-06. Mifepristone 190-196 interleukin 6 Homo sapiens 100-104 23608554-9 2013 Additionally, significantly higher levels of IL-6 and IL-8 were observed in hydroxyurea-treated and untreated patients than in controls respectively (P = 0.04 and P = 0.01). Hydroxyurea 76-87 interleukin 6 Homo sapiens 45-49 18587580-0 2009 CDDO-Me, a synthetic triterpenoid, inhibits expression of IL-6 and Stat3 phosphorylation in multi-drug resistant ovarian cancer cells. bardoxolone methyl 0-7 interleukin 6 Homo sapiens 58-62 18587580-0 2009 CDDO-Me, a synthetic triterpenoid, inhibits expression of IL-6 and Stat3 phosphorylation in multi-drug resistant ovarian cancer cells. triterpenoid TP-222 21-33 interleukin 6 Homo sapiens 58-62 18587580-3 2009 To explore potential therapeutic strategies for interrupting signaling through this pathway, we assessed the ability of CDDO-Me, a synthetic triterpenoid, to inhibit IL-6 secretion, Stat3 phosphorylation, Stat3 nuclear translocation and paclitaxel sensitivity in several cell line model systems. bardoxolone methyl 120-127 interleukin 6 Homo sapiens 166-170 18587580-4 2009 These studies demonstrated that CDDO-Me significantly inhibits IL-6 secretion in paclitaxel-resistant ovarian cancer cells and specifically suppresses IL-6- or oncostatin M-induced Stat3 nuclear translocation. bardoxolone methyl 32-39 interleukin 6 Homo sapiens 63-67 18587580-4 2009 These studies demonstrated that CDDO-Me significantly inhibits IL-6 secretion in paclitaxel-resistant ovarian cancer cells and specifically suppresses IL-6- or oncostatin M-induced Stat3 nuclear translocation. bardoxolone methyl 32-39 interleukin 6 Homo sapiens 151-156 18587580-8 2009 Our data confirm that CDDO-Me interrupts the signaling of multiple kinases involved in the IL-6-Stat3 and Src signaling pathways. bardoxolone methyl 22-29 interleukin 6 Homo sapiens 91-101 18621420-6 2008 BK-mediated IL-6 production was attenuated by phospholipase C inhibitor (U73122), protein kinase Cdelta inhibitor (rottlerin), NF-kappaB inhibitor (PDTC), IkappaB protease inhibitor (TPCK) and NF-kappaB inhibitor peptide. rottlerin 115-124 interleukin 6 Homo sapiens 12-16 18547706-7 2008 The metal allergens nickel and cobalt could be detected by measuring Interleukin-6 and macrophage inflammatory protein 1-beta (MIP-1beta, CCL-4) in coculture supernatants. Cobalt 31-37 interleukin 6 Homo sapiens 69-82 23374147-8 2013 CONCLUSIONS: The increase in the Th1 response in the TIVA-TCI group and the reduction in Tregs in the BAL group seem to balance the immunosuppressive effect induced by IL-6. tregs 89-94 interleukin 6 Homo sapiens 168-172 18451782-7 2008 Plasma IL-6 was positively correlated with glycerol released in response to isoproterenol (10(-5) to 10(-8) mol/l) by isolated SC (0.31 <or= r <or= 0.65, P<0.05) and OM (0.36 <or= r <or= 0.40, P<0.02) adipocytes, independent of menopausal status. Isoproterenol 76-89 interleukin 6 Homo sapiens 7-11 18451782-10 2008 OM adipocyte glycerol release in response to isoproterenol (10(-5) to 10(-8) mol/l) was higher in the subsample of women with elevated plasma IL-6 (P <or= 0.07). Isoproterenol 45-58 interleukin 6 Homo sapiens 142-146 18451782-12 2008 These results suggest that higher circulating IL-6 concentrations are associated with increased isoproterenol-stimulated lipolysis especially in OM abdominal adipocytes in women. Isoproterenol 96-109 interleukin 6 Homo sapiens 46-50 18546154-6 2008 DCIP-selective antisense oligodeoxynucleotide inhibited the expression of TNF-alpha-responsive gene targets including vascular cell adhesion molecule-1, intercellular adhesion molecule-1, IL-6, IL-8, IP-10, and thymic stromal lymphopoietin. Oligodeoxyribonucleotides 25-45 interleukin 6 Homo sapiens 188-192 19103208-6 2009 Inhibitors of STAT1, mitogen activated protein kinase kinase (MEK) (PD98059), and phosphatidyl inositol 3 kinase (PI3K) (LY294002), blocked gp120-induced STAT1 activation and significantly diminished IL-8-, IL-6-, and gp120-induced monocyte adhesion and migration across in vitro BBB models. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 121-129 interleukin 6 Homo sapiens 207-211 18997637-11 2009 When preincubated with tumor-necrosis-factor alpha, lipopolysaccharides and interleukin-6 for 24 hours and subsequently treated with Voriconazole at concentrations up to 250 microg/mL for 24 hours no significant decrease in proliferation and viability was observed. Voriconazole 133-145 interleukin 6 Homo sapiens 76-89 23032719-6 2013 Interestingly, treatment of cells with sodium pervanadate abrogated the inhibition of evodiamine on IL-6-induced STAT3 (Tyr(705)) activation indicating the involvement of protein tyrosine phosphatases. Sodium orthovanadate 39-57 interleukin 6 Homo sapiens 100-104 19182377-2 2009 The number of vacuoles formed by DEX, DEX/OSM, or DEX/IL-6 was significantly suppressed by RU-486, a glucocorticoid receptor antagonist. Mifepristone 91-97 interleukin 6 Homo sapiens 54-58 19182377-3 2009 On the other hand, the size of vacuoles formed by OSM, IL-6, DEX/OSM, or DEX/IL-6 was significantly decreased to about 65% by madindoline A (MDL-A), which is a non-peptide antagonist of gp130 and an inhibitor of cytokines, such as IL-6, mediated by gp130 homodimerization, while RU-486 did not affect the size of vacuoles. Mifepristone 279-285 interleukin 6 Homo sapiens 77-81 19182377-3 2009 On the other hand, the size of vacuoles formed by OSM, IL-6, DEX/OSM, or DEX/IL-6 was significantly decreased to about 65% by madindoline A (MDL-A), which is a non-peptide antagonist of gp130 and an inhibitor of cytokines, such as IL-6, mediated by gp130 homodimerization, while RU-486 did not affect the size of vacuoles. Mifepristone 279-285 interleukin 6 Homo sapiens 77-81 18410446-2 2008 Cerulenin triggered growth inhibition in both MM cell lines and MM patient cells, and overcame the survival and growth advantages conferred by interleukin-6, insulin-like growth factor-1, and bone marrow stromal cells. Cerulenin 0-9 interleukin 6 Homo sapiens 143-156 23343403-14 2013 CCN4-mediated IL-6 production was attenuated by PI3K inhibitor (LY294002 and Wortmannin), Akt inhibitor (Akti), and NF-kappaB inhibitor (PDTC and TPCK). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 64-72 interleukin 6 Homo sapiens 14-18 18715885-3 2008 The time courses for silica-induced release of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-8 both from co-cultures and monocyte mono-cultures showed an early peak at 5-10 h, almost no response at 20 h, and a strong increase at 43 h. At 43 h, co-cultures also showed strongly increased IL-6 levels. Silicon Dioxide 21-27 interleukin 6 Homo sapiens 307-311 18715885-4 2008 Steady-state levels of mRNA roughly exhibited the same pattern of early up-regulation and reduced levels at 20 h. Compared with monocyte mono-cultures, silica induced a strong release of IL-1beta, IL-6, and IL-8, but not of TNF-alpha, after 43 h in co-cultures, whereas at 5 and 10 h a significant difference was only observed for the silica-induced IL-8 response. Silicon Dioxide 152-158 interleukin 6 Homo sapiens 197-201 18835437-7 2009 In the vaccine/stress group, participants with larger IL-6 responses had heightened systolic blood pressure responses to tasks and elevated post-stress salivary levels of the noradrenaline metabolite 3-methoxy-phenyl glycol (MHPG) and cortisol. 3-methoxy-phenyl glycol 200-223 interleukin 6 Homo sapiens 54-58 19118018-6 2009 Culturing IL-6R-positive neuroblastoma cells in the presence of BMSC or recombinant human IL-6 increased proliferation and protected tumor cells from etoposide-induced apoptosis, whereas it had no effect on IL-6R-negative tumor cells. Etoposide 150-159 interleukin 6 Homo sapiens 10-14 19018239-12 2009 Plasma IL-6 level was, however, higher in CS group than in DS group (P<0.01) and was returned to baseline levels in both groups at 72 h after stenting. Cesium 42-44 interleukin 6 Homo sapiens 7-11 23674892-10 2013 CpG oligodeoxynucleotides loaded onto BNNS-CS complexes significantly enhanced production of interleukin-6 and tumor necrosis factor-alpha by peripheral blood mononuclear cells compared with CpG oligodeoxynucleotides directly loaded onto BNNS, or when Lipofectamine 2000 was used as the carrier. Oligodeoxyribonucleotides 4-25 interleukin 6 Homo sapiens 93-138 19091070-7 2008 We further demonstrated that the neutralisation of IL-6 in CBMC culture partially abrogated the anti-apoptotic effect of IGF-1 on T cells. cbmc 59-63 interleukin 6 Homo sapiens 51-55 18413761-3 2008 The present studies show that CDDO-Me blocks interleukin-6 (IL-6)-induced and constitutive activation of the Janus-activated kinase 1 (JAK1) in cells. bardoxolone methyl 30-37 interleukin 6 Homo sapiens 45-58 18413761-3 2008 The present studies show that CDDO-Me blocks interleukin-6 (IL-6)-induced and constitutive activation of the Janus-activated kinase 1 (JAK1) in cells. bardoxolone methyl 30-37 interleukin 6 Homo sapiens 60-64 18413761-5 2008 In concert with these results, CDDO-Me blocked IL-6-induced and constitutive activation of signal transducer and activator of transcription 3 (STAT3). bardoxolone methyl 31-38 interleukin 6 Homo sapiens 47-51 24078775-3 2013 Pyrrolidine dithiocarbamate (PDTC, a selective chemical inhibitor of NF- kappa B) and goat anti-human IL-6 polyclonal neutralizing antibody were used to inhibit NF- kappa B activation and IL-6 production, respectively. pyrrolidine dithiocarbamic acid 0-27 interleukin 6 Homo sapiens 188-192 18390697-3 2008 These rapid IL-6-independent IL-17 producers were identified as predominantly DX5(+) TCRbeta(+) NKT cells, and a comparable response could be found using the invariant NKT-specific ligand alpha-galactosylceramide. alpha-galactosylceramide 188-212 interleukin 6 Homo sapiens 12-16 19036603-7 2008 The mean percentage of the inhibition of IL-6, CXCL8/IL-8, CCL3/MIP-1alpha by bestatin at a concentration of 50 microg/mL was 71.2%, 29.7% and 61.0%, respectively. ubenimex 78-86 interleukin 6 Homo sapiens 41-45 19036603-9 2008 The treatment with bestatin significantly inhibited the production of IL-6 and CXCL8/IL-8 by AM from patients with sarcoidosis. ubenimex 19-27 interleukin 6 Homo sapiens 70-74 24553013-0 2013 Increased IL-6 trans-signaling in depression: focus on the tryptophan catabolite pathway, melatonin and neuroprogression. tryptophan catabolite 59-80 interleukin 6 Homo sapiens 10-14 19022976-7 2008 Arg(high)/Gln(high) decreased the production of TNFalpha, IL-1beta, IL-8, and IL-6 (each P < 0.01). Glutamine 10-13 interleukin 6 Homo sapiens 78-82 19022976-8 2008 Arg(low)/Gln(high) decreased IL-6 and IL-8 production (both P < 0.01), whereas Arg(high)/Gln(low) did not affect cytokine and NO production. Glutamine 9-12 interleukin 6 Homo sapiens 29-33 18975306-12 2008 The selective alpha7R agonist PNU-282,987 decreased the production of IL-6 by IL-1-stimulated FLS. N-neopentyl-N-nitrosourea 30-33 interleukin 6 Homo sapiens 70-74 22646055-8 2012 Moreover, there was a significant correlation between circulating levels of IL-6 and those of ammonia in patients with MHE (r = 0.61, P < 0.05), and a positive additive interaction was found between IL-6 and ammonia on the presence of MHE, with a significant synergy index of 1.51 (95% confidence interval = 1.12-3.46). mhe 119-122 interleukin 6 Homo sapiens 76-80 18922994-7 2008 The combination of IL-6 with ISAT yielded a higher area under the receiver operating characteristic curve (0.61) than either ISAT or IL-6 alone (P = 0.03 and P = 0.02, respectively). isat 125-129 interleukin 6 Homo sapiens 19-23 18027847-7 2008 Conversely, targeted knockdown of cyclin A1 via shRNA in LNCaP IL6+ cells resulted in decreased survival after treatment with camptothecin. Camptothecin 126-138 interleukin 6 Homo sapiens 63-66 18066713-3 2008 When coincubating A549 with LPS and meta-iodobenzylguanidine or novobiocin, selective arginine-dependent ART-inhibitors, the release of IL-6 and IL-8 was inhibited in a concentration-dependent manner. 3-Iodobenzylguanidine 36-60 interleukin 6 Homo sapiens 136-140 18477937-10 2008 IL-6 secretion was elevated in all hyperoxic groups at 24 hrs (p < .001), and both IL-6 and IL-8 levels were greater in the 40% FiO2 group compared with all other groups at 72 hrs (p < .01). fio2 131-135 interleukin 6 Homo sapiens 86-90 18638462-9 2008 Taken together, these results indicate that IQDMA causes significant induction of apoptosis in HL-60 cells via down-regulation of Src, IL-6, and STAT5 signaling and modulation of Bcl-2 family, cyclin D1 and VEGF proteins. N'-(11H-indolo(3,2-c)quinolin-6-yl)-N,N-dimethylethane-1,2-diamine 44-49 interleukin 6 Homo sapiens 135-139 22646055-8 2012 Moreover, there was a significant correlation between circulating levels of IL-6 and those of ammonia in patients with MHE (r = 0.61, P < 0.05), and a positive additive interaction was found between IL-6 and ammonia on the presence of MHE, with a significant synergy index of 1.51 (95% confidence interval = 1.12-3.46). mhe 238-241 interleukin 6 Homo sapiens 76-80 22646055-8 2012 Moreover, there was a significant correlation between circulating levels of IL-6 and those of ammonia in patients with MHE (r = 0.61, P < 0.05), and a positive additive interaction was found between IL-6 and ammonia on the presence of MHE, with a significant synergy index of 1.51 (95% confidence interval = 1.12-3.46). mhe 238-241 interleukin 6 Homo sapiens 202-206 18296320-4 2008 Omega-3 fatty acids have strong anti-inflammatory effects, suppress interleukin 1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF alpha) and interleukin-6 (IL-6), whereas omega-6 fatty acids tend to be pro-inflammatory. Fatty Acids, Omega-3 0-19 interleukin 6 Homo sapiens 144-157 23041664-9 2012 ETR-P1/fl administration after CLP resulted in lower serum TH at 1 and 3 h after CLP, OSI at 1 and 3 h after CLP, IL-6 at 1 and 3 h after CLP, and GOT at 3 and 6 h after CLP as compared with the CLP group. fl 7-9 interleukin 6 Homo sapiens 114-118 18296320-4 2008 Omega-3 fatty acids have strong anti-inflammatory effects, suppress interleukin 1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF alpha) and interleukin-6 (IL-6), whereas omega-6 fatty acids tend to be pro-inflammatory. Fatty Acids, Omega-3 0-19 interleukin 6 Homo sapiens 159-163 18209571-10 2008 LPS-induced IL-6 promoter activation was also prevented by pretreatment with epigallocatechin 3-gallate, curcumin, and resveratrol. epigallocatechin gallate 77-103 interleukin 6 Homo sapiens 12-16 18502114-0 2008 An interleukin-6 ZnO/SiO(2)/Si surface acoustic wave biosensor. Zinc Oxide 17-20 interleukin 6 Homo sapiens 3-16 18502114-0 2008 An interleukin-6 ZnO/SiO(2)/Si surface acoustic wave biosensor. Silicon Dioxide 21-27 interleukin 6 Homo sapiens 3-16 18502114-1 2008 A novel high sensitivity ZnO/SiO(2)/Si Love mode surface acoustic wave (SAW) biosensor for the detection of interleukin-6 (IL-6), is reported. Zinc Oxide 25-28 interleukin 6 Homo sapiens 108-121 18502114-1 2008 A novel high sensitivity ZnO/SiO(2)/Si Love mode surface acoustic wave (SAW) biosensor for the detection of interleukin-6 (IL-6), is reported. Zinc Oxide 25-28 interleukin 6 Homo sapiens 123-127 23041664-10 2012 CONCLUSION: ETR-P1/fl treatment significantly attenuated the elevation of serum oxidative stress markers (TH and OSI), IL-6, and GOT in a progressive neonatal sepsis CLP model. fl 19-21 interleukin 6 Homo sapiens 119-123 18502114-1 2008 A novel high sensitivity ZnO/SiO(2)/Si Love mode surface acoustic wave (SAW) biosensor for the detection of interleukin-6 (IL-6), is reported. Silicon Dioxide 29-35 interleukin 6 Homo sapiens 108-121 18502114-1 2008 A novel high sensitivity ZnO/SiO(2)/Si Love mode surface acoustic wave (SAW) biosensor for the detection of interleukin-6 (IL-6), is reported. Silicon Dioxide 29-35 interleukin 6 Homo sapiens 123-127 22837010-0 2012 Identification of granulocyte colony-stimulating factor and interleukin-6 as candidate biomarkers of CBLB502 efficacy as a medical radiation countermeasure. CBLB502 101-108 interleukin 6 Homo sapiens 60-73 18502114-2 2008 The biosensors operating at 747.7 MHz and 1.586 GHz were functionalized by immobilizing the monoclonal IL-6 antibody onto the ZnO biosensor surface both through direct surface adsorption and through covalent binding on gluteraldehyde. Zinc Oxide 126-129 interleukin 6 Homo sapiens 103-107 18311073-8 2008 RESULTS: IL-6 and TNF-alpha in EBC and serum gave the highest correlation coefficients (r = 0.62 and r = 0.71 in EBC; r = 0.58 and r = 0.66 in serum, respectively) as well as the lowest AIC values (63.87, 68.97; 62.65, 70.64, respectively). NSC638702 31-34 interleukin 6 Homo sapiens 9-13 18418962-8 2008 CONCLUSION: Oxymatrine could lower the levels of cytokines, including TGF-beta1, IL-6, etc. oxymatrine 12-22 interleukin 6 Homo sapiens 81-85 18606530-7 2008 We measured pH, 8-isoprostane, TNF-alpha and IL-6 in EBC and leptin in plasma. NSC638702 53-56 interleukin 6 Homo sapiens 45-49 22837010-7 2012 Induction of both G-CSF and IL-6 by CBLB502 1) is strictly TLR5-dependent, 2) occurs in a CBLB502 dose-dependent manner within its efficacious dose range in both nonirradiated and irradiated mammals, including nonhuman primates, and 3) is critically important for the ability of CBLB502 to rescue irradiated animals from death. CBLB502 36-43 interleukin 6 Homo sapiens 28-32 22837010-7 2012 Induction of both G-CSF and IL-6 by CBLB502 1) is strictly TLR5-dependent, 2) occurs in a CBLB502 dose-dependent manner within its efficacious dose range in both nonirradiated and irradiated mammals, including nonhuman primates, and 3) is critically important for the ability of CBLB502 to rescue irradiated animals from death. CBLB502 90-97 interleukin 6 Homo sapiens 28-32 22158046-6 2012 IL-6/PAI-1 expression and secretion were strongly inhibited by the tyrosine kinase inhibitor AG1478 and EGFR silencing. RTKI cpd 93-99 interleukin 6 Homo sapiens 0-4 18830451-1 2008 We determined the therapeutic efficacy of atractylenolide I (ATR), extracted from largehead atractylodes rhizome, in managing gastric cancer cachexia (GCC), and interpreted its probable pharmacological mechanism via investigating tumor necrosis factor alpha (TNF-alpha), interleukin-1 (IL-1), interleukin-6 (IL-6) and proteolysis-inducing factor (PIF). (+)-Atractylenolide 42-57 interleukin 6 Homo sapiens 293-306 18830451-1 2008 We determined the therapeutic efficacy of atractylenolide I (ATR), extracted from largehead atractylodes rhizome, in managing gastric cancer cachexia (GCC), and interpreted its probable pharmacological mechanism via investigating tumor necrosis factor alpha (TNF-alpha), interleukin-1 (IL-1), interleukin-6 (IL-6) and proteolysis-inducing factor (PIF). (+)-Atractylenolide 42-57 interleukin 6 Homo sapiens 308-312 17645497-0 2007 Auranofin blocks interleukin-6 signalling by inhibiting phosphorylation of JAK1 and STAT3. Auranofin 0-9 interleukin 6 Homo sapiens 17-30 18210237-0 2007 Costunolide inhibits production of tumor necrosis factor-alpha and interleukin-6 by inducing heme oxygenase-1 in RAW264.7 macrophages. costunolide 0-11 interleukin 6 Homo sapiens 67-80 22158046-7 2012 A significant reduction of EGF-stimulated IL-6/PAI-1 secretion was also obtained with the NFkB inhibitor dehydroxymethylepoxyquinomicin. dehydroxymethylepoxyquinomicin 105-135 interleukin 6 Homo sapiens 42-46 17561367-3 2007 When cells were exposed to SR, syringin, or isofraxidin, only isofraxidin had significant inhibitory effects on cell growth, although a slight inhibition was observed at the highest concentration of SR. SR suppressed the production of IL-6 at lower concentrations than syringin and isofraxidin. isofraxidin 44-55 interleukin 6 Homo sapiens 235-239 17561367-3 2007 When cells were exposed to SR, syringin, or isofraxidin, only isofraxidin had significant inhibitory effects on cell growth, although a slight inhibition was observed at the highest concentration of SR. SR suppressed the production of IL-6 at lower concentrations than syringin and isofraxidin. isofraxidin 62-73 interleukin 6 Homo sapiens 235-239 17561367-3 2007 When cells were exposed to SR, syringin, or isofraxidin, only isofraxidin had significant inhibitory effects on cell growth, although a slight inhibition was observed at the highest concentration of SR. SR suppressed the production of IL-6 at lower concentrations than syringin and isofraxidin. isofraxidin 62-73 interleukin 6 Homo sapiens 235-239 17561367-5 2007 SR was more potent than syringin and isofraxidin at inhibiting the expression of IL-1beta, IL-6, cyclooxygenase (COX)-2 and matrix metalloproteinases (MMP)-1 mRNA, but was less potent than syringin at inhibiting the expression of MMP-2. isofraxidin 37-48 interleukin 6 Homo sapiens 91-95 17705048-7 2007 Treatment of MG-63 with the ADORA(2a)-specific antagonist ZM241385 partially reversed the inhibitory effects of ADORA stimulation on LPS-induced IL-6 release. ZM 241385 58-66 interleukin 6 Homo sapiens 145-149 18625560-0 2008 Synthesis and evaluation of pyrazolo[3,4-b]pyridines and its structural analogues as TNF-alpha and IL-6 inhibitors. pyrazolo(3,4-b)pyridine 28-52 interleukin 6 Homo sapiens 99-103 22745245-9 2012 There was a fall in protein expression of c-Jun N-terminal kinase-1, IKKbeta, and TLR-4 and in plasma concentrations of C-reactive protein, IL-6, and free fatty acids after 12 wk of sitagliptin. Sitagliptin Phosphate 182-193 interleukin 6 Homo sapiens 140-144 18758498-10 2008 Pulmonary tissue concentration of IL-6 was significantly suppressed by LU 135252 inhalation (4 +/- 1 pg.100 mg-1 wet weight vs. control 7 +/- 1 pg.100 mg(-1) wet weight, p < 0.05). darusentan 71-80 interleukin 6 Homo sapiens 34-38 17785784-4 2007 In this study, we show that monocyte-derived DCs pretreated with the vitamin A derivative all-trans retinoic acid (RA) indeed acquired several attributes characteristic of mucosal DC: secretion of TGF-beta and IL-6 and the capacity to augment mucosal homing receptor expression and IgA responses in cocultured lymphocytes. Vitamin A 69-78 interleukin 6 Homo sapiens 210-214 17953377-0 2007 [Verapamil effect and influence on postoperative epidural analgesia and cell factors TNFalpha, IL-6 and IL-2]. Verapamil 1-10 interleukin 6 Homo sapiens 95-99 22766331-7 2012 RESULTS: Diosgenin significantly reduced PA-enhanced IKKbeta and NF-kappaB phosphorylation with inhibition of TNF-alpha and IL-6 production in endothelial cells at the concentrations of 0.1, 1 and 10 mumol/L, well demonstrating its anti-inflammatory activity in an IKKbeta/NF-kappaB-dependent fashion. Diosgenin 9-18 interleukin 6 Homo sapiens 124-128 17451794-0 2007 3-O-Formyl-20R,21-epoxyresibufogenin suppresses IL-6-type cytokine actions by targeting the glycoprotein 130 subunit: potential clinical implications. [(1R,2S,4R,6R,7R,10S,11S,14S,16R)-7,11-dimethyl-6-[(1R,6R)-3-oxo-2,7-dioxabicyclo[4.1.0]hept-4-en-6-yl]-3-oxapentacyclo[8.8.0.02,4.02,7.011,16]octadecan-14-yl] formate 0-36 interleukin 6 Homo sapiens 48-52 18455292-9 2008 Etoposide strongly increased expression of IL-6 and decreased that of OPG. Etoposide 0-9 interleukin 6 Homo sapiens 43-47 18455292-14 2008 In addition, E2 and Osp opposed the etoposide-induced increase of IL-6 and decrease of OPG which changes would increase osteoclastic activity. Etoposide 36-45 interleukin 6 Homo sapiens 66-70 18308843-3 2008 IL-6 release stimulated by TSH was inhibited by 35% (P < 0.05) with SN50, an inhibitor of nuclear factor-kappaB (NF-kappaB) nuclear translocation, and 60% (P < 0.01) with sc-514, an inhibitor of inhibitory-kappaB (IkappaB) kinase (IKK)-beta. SC 514 177-183 interleukin 6 Homo sapiens 0-4 17451794-8 2007 The soluble glycoprotein 130, but not the soluble IL-6 receptor, antagonized TB-2-081-induced suppression of IL-6-stimulated AACT mRNA expression. 20,21-epoxyresibufogenin-3-formate 77-85 interleukin 6 Homo sapiens 109-113 22766331-7 2012 RESULTS: Diosgenin significantly reduced PA-enhanced IKKbeta and NF-kappaB phosphorylation with inhibition of TNF-alpha and IL-6 production in endothelial cells at the concentrations of 0.1, 1 and 10 mumol/L, well demonstrating its anti-inflammatory activity in an IKKbeta/NF-kappaB-dependent fashion. Palmitates 41-43 interleukin 6 Homo sapiens 124-128 17442294-0 2007 Vitamin B12 and hepatic enzyme serum levels correlate with interleukin-6 in alcohol-dependent individuals without liver disease. Vitamin B 12 0-11 interleukin 6 Homo sapiens 59-72 22641358-7 2012 We found that IL-1Ra and EGCG downregulated IL-1-induced IL-6 and IL-8 release from U-2 OS cells by 65-85%. epigallocatechin gallate 25-29 interleukin 6 Homo sapiens 57-61 17442294-2 2007 The aim of the present study was to investigate the possible correlation, between liver dysfunction biological markers and vitamin B12, with interleukin-6, in the serum of alcohol-dependent individuals without liver disease (AWLD). Vitamin B 12 123-134 interleukin 6 Homo sapiens 141-154 18552237-5 2008 The low-GDP solution group showed significantly higher dialysate levels of cancer antigen 125 (CA125), fibronectin, transforming growth factor beta(TGFbeta)-induced gene product (betaig-h3), and interleukin-6 (IL-6), but the rate of EMT was significantly lower in the low-GDP solution group during the initial 12 months of CAPD treatment. Guanosine Diphosphate 8-11 interleukin 6 Homo sapiens 195-208 18552237-5 2008 The low-GDP solution group showed significantly higher dialysate levels of cancer antigen 125 (CA125), fibronectin, transforming growth factor beta(TGFbeta)-induced gene product (betaig-h3), and interleukin-6 (IL-6), but the rate of EMT was significantly lower in the low-GDP solution group during the initial 12 months of CAPD treatment. Guanosine Diphosphate 8-11 interleukin 6 Homo sapiens 210-214 18552237-6 2008 After adjusting peritoneal growth factors for dialysate CA125 concentration, the low-GDP solution group showed significantly lower ratios of fibronectin/CA125, betaig-h3/CA125, IL-6/CA125, TGFbeta/CA125, and vascular endothelial growth factor (VEGF)/CA125 than did patients in the high-GDP (standard) solution group. Guanosine Diphosphate 85-88 interleukin 6 Homo sapiens 177-181 17314215-8 2007 The production of IL-1beta, IL-6 and IL-8 induced by TNF-alpha was decreased by pyrrolidine dithiocarbamate (PDTC), a chemical inhibitor of NF-kappaB. pyrrolidine dithiocarbamic acid 80-107 interleukin 6 Homo sapiens 28-32 22641358-9 2012 In conclusion, downregulation of IL-1-induced tumorigenic factors (IL-6, IL-8, VEGF, MMP-2) in U-2 OS by IL-1Ra and EGCG may positively affect tumor-associated inflammation and, as a consequence, lead to reduction in angiogenesis and invasiveness. epigallocatechin gallate 116-120 interleukin 6 Homo sapiens 67-71 17314215-8 2007 The production of IL-1beta, IL-6 and IL-8 induced by TNF-alpha was decreased by pyrrolidine dithiocarbamate (PDTC), a chemical inhibitor of NF-kappaB. pyrrolidine dithiocarbamic acid 109-113 interleukin 6 Homo sapiens 28-32 22808498-8 2012 Orthodontic structures made from chromium-cobalt, or chromium-nickel alloys in the oral cavity of these patients increased the levels of MMP-2, IL-1beta and IL-6 in oral fluid. Cobalt 42-48 interleukin 6 Homo sapiens 157-161 17314215-11 2007 TNF-alpha-induced production of IL-1beta, IL-6 and IL-8 was hampered by treatment with the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6 and IL-8 production induced by TNF-alpha. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 137-145 interleukin 6 Homo sapiens 42-46 17314215-11 2007 TNF-alpha-induced production of IL-1beta, IL-6 and IL-8 was hampered by treatment with the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6 and IL-8 production induced by TNF-alpha. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 137-145 interleukin 6 Homo sapiens 216-220 17524151-8 2007 Also, roxithromycin inhibited the SM-stimulated overproduction of the proinflammatory cytokines IL-1beta, IL-6, IL-8 and TNF at both the protein level and the mRNA level, as measured by either enzyme-linked immunosorbent assay (ELISA) or real-time RT-PCR. Roxithromycin 6-19 interleukin 6 Homo sapiens 106-110 17524151-8 2007 Also, roxithromycin inhibited the SM-stimulated overproduction of the proinflammatory cytokines IL-1beta, IL-6, IL-8 and TNF at both the protein level and the mRNA level, as measured by either enzyme-linked immunosorbent assay (ELISA) or real-time RT-PCR. Mustard Gas 34-36 interleukin 6 Homo sapiens 106-110 18436114-13 2008 Changes in IL-6 and hs-CRP after 12 weeks of darapladib 160 mg suggest a possible reduction in inflammatory burden. darapladib 45-55 interleukin 6 Homo sapiens 11-15 18239561-8 2008 Elevated (P < 0.001) concentrations of IL-6 following moderate (50% VO(2)) and high (75% VO(2)) intensity acute exercise were observed in both groups; however, concentrations of TNF-alpha were unchanged in response to acute exercise (P = 0.584). vo(2)) 71-77 interleukin 6 Homo sapiens 42-46 22564635-8 2012 CONCLUSION: The IL-6/STAT3 pathway of Hep-G2 cells after ischemic injury showed beneficial effects on insulin secretion of RIN-5f cells cocultured with themselves. rin-5f 123-129 interleukin 6 Homo sapiens 16-20 18154618-5 2008 Inhibition of regulatory cells, suppressor pathways or cytokines, is consistent with CS and can be attributed to IL-6, IL-2, PD-1 or PD-L-1 antibodies, blockade of CTLA-4 : CD80/86 pathway, inhibition of CD40-CD40L pathways, and TGF-beta, IL-10 antibodies. Cesium 85-87 interleukin 6 Homo sapiens 113-117 17397353-2 2007 It is now clear that macrolide antibiotics have anti-inflammatory effects, such as inhibition of IL-6, IL-8 and tumour necrosis factor-alpha, perhaps by suppressing the transcription factor nuclear factor-kappaB or activator protein-1, and reduction of neutrophil activity. Macrolides 21-30 interleukin 6 Homo sapiens 97-101 17320913-2 2007 In our present study, we have demonstrated chalcone inhibited IL-6- and LPS-induced ICAM-1 gene expression. Chalcone 43-51 interleukin 6 Homo sapiens 62-66 17320913-4 2007 Chalcone was found to abrogate the activation of STAT3 and NF-kappaB in a dose- and time-dependent manner, in IL-6- and LPS-treated ECs. Chalcone 0-8 interleukin 6 Homo sapiens 110-114 22665731-2 2012 To beginning of the treatment at intensifying of CS at the patients was detected the substantial increase of maintenance of proinflammatory (IL - 1beta, IL - 2, IL - 6, TNF -alpha) cytokines (CK) in the blood serum at the moderate increase of antiinflammatory CK (IL-4). Cesium 49-51 interleukin 6 Homo sapiens 161-167 17023687-6 2007 Plasmacytoid-DC responded to the CpG oligodeoxynucleotide, CpG 2216, by production of the proinflammatory cytokines, IFN-alpha and IL-6. Oligodeoxyribonucleotides 37-57 interleukin 6 Homo sapiens 131-135 17541958-5 2008 Results showed that CS initially delayed the production of "innate" cytokines (e.g., IL-1beta and IL-6) and reduced glutathione levels. Cesium 20-22 interleukin 6 Homo sapiens 98-102 22420994-10 2012 Also, LY294002, an inhibitor of the Akt/PI3K pathway, abrogated the MA-mediated induction of IL-6 and IL-8 by 77.9 +- 6.6% and 81.4 +- 2.6%, respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 6-14 interleukin 6 Homo sapiens 93-97 18789006-3 2008 Initial level of markers of inflammation (Il-6, CRP) in STEACS was lower than in NSTEACS. steacs 56-62 interleukin 6 Homo sapiens 42-46 17095089-7 2007 Thus, our work demonstrates that LPs can synergize with IgE+Ag in stimulating the production of IL-6 by BMMCs. Lipopeptides 33-36 interleukin 6 Homo sapiens 96-100 22313388-8 2012 Besides inhibiting constitutive expression, EGCG also abrogated the interleukin-6 (IL-6)-induced JAK/STAT3 signaling and further inhibited IL-6-induced proliferation on HNSCC cells. epigallocatechin gallate 44-48 interleukin 6 Homo sapiens 68-81 17070997-5 2007 Both rofecoxib and ibuprofen treatment increased the gene expression of the pro-inflammatory mediators, IL6 and CCL2 (chemokine C-C motif ligand 2), following tissue injury compared to the placebo treatment. rofecoxib 5-14 interleukin 6 Homo sapiens 104-107 22313388-8 2012 Besides inhibiting constitutive expression, EGCG also abrogated the interleukin-6 (IL-6)-induced JAK/STAT3 signaling and further inhibited IL-6-induced proliferation on HNSCC cells. epigallocatechin gallate 44-48 interleukin 6 Homo sapiens 83-87 17898021-12 2008 Furthermore, the increased synthesis of IL-6 and TNF-alpha by anionic pIgA in HMC was significantly diminished (P<0.01) in the presence of NF-kappaB inhibitor pyrrolidine dithiocarbamate and NF-kappaB blocking permeable peptides SN50 (P<0.01). pyrrolidine dithiocarbamic acid 162-189 interleukin 6 Homo sapiens 40-44 22313388-8 2012 Besides inhibiting constitutive expression, EGCG also abrogated the interleukin-6 (IL-6)-induced JAK/STAT3 signaling and further inhibited IL-6-induced proliferation on HNSCC cells. epigallocatechin gallate 44-48 interleukin 6 Homo sapiens 139-143 22313388-9 2012 In comparison with apigenin, curcumin, and AG490, EGCG was a more effective inhibitor of IL-6-induced proliferation on HNSCC cells. epigallocatechin gallate 50-54 interleukin 6 Homo sapiens 89-93 18306624-8 2007 The increasing trend of IL-6 and IL-10 levels were similar in both groups, whereas the level of IL-6 at T1 in propofol group was lower than that of isoflurane group significantly (P < 0.01), however the level of IL-10 was much higher in propofol group than that of isoflurane group at T1 and T2 (P < 0.05). Isoflurane 268-278 interleukin 6 Homo sapiens 96-100 22313388-10 2012 Overall, our results strongly suggest that EGCG induces Fas/CD95-mediated apoptosis through inhibiting constitutive and IL-6-induced JAK/STAT3 signaling. epigallocatechin gallate 43-47 interleukin 6 Homo sapiens 120-124 17108260-4 2007 These genes were also found to be NF-kappaB-dependent in that TNFalpha-induced expression of IL-6, IL-8, and eotaxin was dose-dependently inhibited by the selective IKKbeta inhibitor 4-(2"-aminoethyl)amino-1,8-dimethylimidazo[1,2-a]quinoxaline (BMS-345541) (1-30 microM). 4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline 183-243 interleukin 6 Homo sapiens 93-97 21789517-7 2012 The increase in serum interleukin 6 levels from preoperative value to the value at 3 h postoperatively was found to be significantly higher in LAVH group when compared with NDVH group indicating greater tissue handling and trauma in LAVH group. ndvh 173-177 interleukin 6 Homo sapiens 22-35 17108260-4 2007 These genes were also found to be NF-kappaB-dependent in that TNFalpha-induced expression of IL-6, IL-8, and eotaxin was dose-dependently inhibited by the selective IKKbeta inhibitor 4-(2"-aminoethyl)amino-1,8-dimethylimidazo[1,2-a]quinoxaline (BMS-345541) (1-30 microM). 4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline 245-255 interleukin 6 Homo sapiens 93-97 17869048-4 2007 Within the Leiden 85-plus Study, a prospective population-based study of participants aged 85 years and older, we found that carriers of the CFH 402HH variant had a higher production of IL-6 in whole blood samples compared to those carrying the 402YY variant (P=0.029). 402hh 145-150 interleukin 6 Homo sapiens 186-190 21868713-7 2012 HN2-related effects on the secretion of IL-6 and the production of total mucin and MUC5AC were reversed by the selective EGFR inhibitor AG1478 and by an EGFR-blocking antibody. RTKI cpd 136-142 interleukin 6 Homo sapiens 40-44 17964516-0 2007 Thalidomide suppressed interleukin-6 but not tumor necrosis factor-alpha in volunteers with experimental endotoxemia. Thalidomide 0-11 interleukin 6 Homo sapiens 23-36 17964516-11 2007 Using the area under the dose response curve (AUC(0 to 24) h), thalidomide reduced the AUC for IL-6 by 56%, for IL-8 by 30%, and TNF-alpha by 32%. Thalidomide 63-74 interleukin 6 Homo sapiens 95-99 17964516-12 2007 In this model, thalidomide did not suppress TNF-alpha or IL-8, but it did suppress IL-6 at 4-h postinfusion with lipopolysaccharide (P=0.004), at 6 h (P=0.014), at 12 h (P=0.001), and at 16 h (P=0.012). Thalidomide 15-26 interleukin 6 Homo sapiens 83-87 17097222-7 2007 The C16:0 sulfatide has been shown to activate potassium channels in beta-cells, and glibenclamide, an ATP-sensitive K+-(KATP) channel blocker, reversed the C16:0-induced decrement in stimulated TNF-alpha, IL-6, and IL-8 release in adipocytes. Glyburide 85-98 interleukin 6 Homo sapiens 206-210 17012372-0 2007 Moxifloxacin but not ciprofloxacin or azithromycin selectively inhibits IL-8, IL-6, ERK1/2, JNK, and NF-kappaB activation in a cystic fibrosis epithelial cell line. Moxifloxacin 0-12 interleukin 6 Homo sapiens 78-82 21952924-5 2012 TSA was a potent inhibitor of tumor necrosis factor (TNF) and interleukin-6 (IL-6) production in both RA and healthy PBMCs and of interferon-gamma (IFNgamma) production in healthy PBMCs; IFNgamma was not produced by RA PBMCs. trichostatin A 0-3 interleukin 6 Homo sapiens 62-75 17468076-9 2007 Marginal plasma retinol concentrations were associated with high concentrations of IL-6 after LPS stimulation. Vitamin A 16-23 interleukin 6 Homo sapiens 83-87 17855663-4 2007 We found that ursolic acid, a pentacyclic triterpenoid, inhibited both constitutive and interleukin-6-inducible STAT3 activation in a dose- and time-dependent manner in multiple myeloma cells. ursolic acid 14-26 interleukin 6 Homo sapiens 88-101 17855663-4 2007 We found that ursolic acid, a pentacyclic triterpenoid, inhibited both constitutive and interleukin-6-inducible STAT3 activation in a dose- and time-dependent manner in multiple myeloma cells. triterpenoid TP-222 42-54 interleukin 6 Homo sapiens 88-101 18048020-4 2007 CNTO2424 down-regulates poly(I:C)-induced production of IL-6, IL-8, MCP-1, RANTES, and IP-10 in human lung epithelial cells. poly 24-28 interleukin 6 Homo sapiens 56-60 21952924-5 2012 TSA was a potent inhibitor of tumor necrosis factor (TNF) and interleukin-6 (IL-6) production in both RA and healthy PBMCs and of interferon-gamma (IFNgamma) production in healthy PBMCs; IFNgamma was not produced by RA PBMCs. trichostatin A 0-3 interleukin 6 Homo sapiens 77-81 22108347-0 2012 Ursolic acid suppresses IL-6 induced C-reactive protein expression in HepG2 and protects HUVECs from injury induced by CRP. ursolic acid 0-12 interleukin 6 Homo sapiens 24-28 17395587-3 2007 In this study we investigate the effects of common asthma treatments fluticasone propionate and beta(2) agonists salmeterol and salbutamol on IL-6 production in BEAS-2B and primary bronchial epithelial cells. Albuterol 128-138 interleukin 6 Homo sapiens 142-146 17395587-4 2007 Salmeterol and salbutamol enhanced rhinovirus- and IL-1beta-induced IL-6 production; however, fluticasone treatment caused a reduction of IL-6 protein and mRNA. Albuterol 15-25 interleukin 6 Homo sapiens 68-72 17400256-8 2007 In vitro, HES suppressed the expression of IL-8 on A549 cells and THP-1 cells, the expression of TNF-alpha, IL-1 beta, and IL-6 on THP-1 cells, the expression of ICAM-1 and VCAM-1 on A549 cells which effect cell adhesion function. Hesperidin 10-13 interleukin 6 Homo sapiens 123-127 17400256-10 2007 HES inhibits those pathways, thereby suppressing the expression of IL-8, TNFalpha, IL-1 beta, IL-6, IL-12, ICAM-1 and VCAM-1. Hesperidin 0-3 interleukin 6 Homo sapiens 94-98 17404287-2 2007 We previously demonstrated that genistein suppresses TNF-alpha-induced NF-kappaB-dependent IL-6 gene expression in cancer cells by interfering with the mitogen- and stress-activated protein kinase 1 activation pathway. Genistein 32-41 interleukin 6 Homo sapiens 91-95 17404287-5 2007 More particularly, we observe that genistein inhibits IL-6 gene expression by modulating the transcription factor NF-kappaB. Genistein 35-44 interleukin 6 Homo sapiens 54-58 17404287-9 2007 Moreover, analysis of IL-6 mRNA levels in bone marrow-derived p53 null vs wild-type dendritic cells confirms a role for p53 in the reduction of NF-kappaB-dependent gene expression, mediated by genistein. Genistein 193-202 interleukin 6 Homo sapiens 22-26 17348870-7 2007 MATERIALS AND METHODS: We transferred high amounts of aAb-IL-6 to two patients suffering from end-stage disease of multiple myeloma. p-Aminoazobenzene 54-57 interleukin 6 Homo sapiens 58-62 17277312-3 2007 We found that IL-6 functioned to up-regulate IL-23R and that IL-23 synergized with IL-6 in promoting THi generation. 2-acetyl-4(5)-tetrahydroxybutylimidazole 101-104 interleukin 6 Homo sapiens 83-87 17277312-4 2007 STAT3, activated by both IL-6 and IL-23, plays a critical role in THi development. 2-acetyl-4(5)-tetrahydroxybutylimidazole 66-69 interleukin 6 Homo sapiens 25-29 17389308-7 2007 In stepwise models adjusted for clinical covariates with backwards elimination of markers, IL-6 and OPG were inversely associated with TCBV; TNFalpha was inversely related to TCBV in a subset of 1,430 participants. tcbv 135-139 interleukin 6 Homo sapiens 91-95 17320913-15 2007 Hence, our present findings indicate that chalcone suppresses both IL-6- and LPS-induced signaling pathways through the thiol-dependent intracellular redox state. Chalcone 42-50 interleukin 6 Homo sapiens 67-71 16946718-5 2007 SQ22563, an adenylate cyclase inhibitor, inhibited ATP-induced IL-6 release. sq22563 0-7 interleukin 6 Homo sapiens 63-67 17237426-4 2007 In the present study, we found that the fiber-modified Ad vector containing poly-lysine peptides in the fiber knob showed much lower serum IL-6 and aspartate aminotransferase levels (as a maker of liver toxicity) than the conventional Ad vector after i.v. poly 76-80 interleukin 6 Homo sapiens 139-143 17224793-7 2007 The SA treatment also decreased cytomix-induced IL-6 and IL-8 production in a dose-dependent manner. sodium arsenite 4-6 interleukin 6 Homo sapiens 48-52 17710582-7 2007 RESULTS: Our data suggest that clonidine can stimulate anti-inflammatory IL-10 production from PBMC while decreasing pro-inflammatory TNF-alpha, whereas low doses of hydralazine increased the production of IL-10, TNF-alpha, and IL-6 from preeclamptic PBMCs. Hydralazine 166-177 interleukin 6 Homo sapiens 228-232 17710582-8 2007 There was a reduction in IL-10, TNF-alpha, and IL-6 production with increasing doses of clonidine and hydralazine by placentas in preeclampsia. Hydralazine 102-113 interleukin 6 Homo sapiens 47-51 17377406-4 2007 The aim of the study was to compare the in vitro effect of vitamin A on the production of pro-inflammatory (IL-1beta and IL-6) and anti-inflammatory (IL-1 receptor antagonist (ra) and IL-10) cytokines, as well as IL-2 and IFNgamma by cord blood mononuclear cells (CBMC) of preterm newborns to that of peripheral blood mononuclear cells (PBMC) from adults. Vitamin A 59-68 interleukin 6 Homo sapiens 121-125 17377406-7 2007 RESULTS: Vitamin A exerted an in vitro inhibitory effect on the production of the anti-inflammatory cytokine IL-1ra by MC of preterm newborns and adults, but did not affect the secretion of the pro-inflammatory cytokines IL-1beta, IL-6 and IFNgamma. Vitamin A 9-18 interleukin 6 Homo sapiens 231-235 16581242-0 2006 Morphological and binding properties of interleukin-6 on thin ZnO films grown on (100) silicon substrates for biosensor applications. Zinc Oxide 62-65 interleukin 6 Homo sapiens 40-53 16581242-2 2006 Interleukin-6 was immobilized in the range of 0.276-10 pg/ml on the surface of ZnO and SiO(2), and visualized at each stage, while protein-protein interactions were measured with the antigen/antibody immunoassay of solid-phase ELISA, which we modified for these types of substrates. Zinc Oxide 79-82 interleukin 6 Homo sapiens 0-13 17261774-13 2006 However, since release of IL-6 is frequent in HCC, especially in its more advanced stages, the use of agents like curcumin or DHMEQ might be beneficial to counteract its adverse systemic effects (e.g., cachexia). dehydroxymethylepoxyquinomicin 126-131 interleukin 6 Homo sapiens 26-30 17045449-5 2006 Omega-3 fatty acids have anti-inflammatory effects, suppress interleukin 1beta (IL-1beta), tumor necrosis factor-alpha (TNFalpha) and interleukin-6 (IL-6), whereas omega-6 fatty acids do not. Fatty Acids, Omega-3 0-19 interleukin 6 Homo sapiens 134-147 17045449-5 2006 Omega-3 fatty acids have anti-inflammatory effects, suppress interleukin 1beta (IL-1beta), tumor necrosis factor-alpha (TNFalpha) and interleukin-6 (IL-6), whereas omega-6 fatty acids do not. Fatty Acids, Omega-3 0-19 interleukin 6 Homo sapiens 149-153 16330117-6 2006 RESULTS: Malondialdehyde, C-reactive protein and interleukin-6 levels were reduced in the rofecoxib group (p=0.04, p=0.003 and p=0.02 respectively) while they remained unchanged in the placebo group after 1 week of treatment. rofecoxib 90-99 interleukin 6 Homo sapiens 49-62 17075545-2 2006 In vitro studies have demonstrated the anti-inflammatory effects of macrolides: decreased productions of IL-6, IL-8, TNF alpha, chemotactism of polymorphonuclear neutrophils. Macrolides 68-78 interleukin 6 Homo sapiens 105-109 16728278-10 2006 LY-294002 completely blocked these effects of IL-6. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-9 interleukin 6 Homo sapiens 46-50 16547349-10 2006 At 50 nM, A1, A2, and the endogenous cannabinoid anandamide (CB2 Ki >200 nM) up-regulated constitutive interleukin (IL)-6 expression in human whole blood in a seemingly CB2-dependent manner. anandamide 49-59 interleukin 6 Homo sapiens 106-124 16583305-4 2006 The incubation with Ni-Ti heat-activated (T3) or Ni-Ti super-elastic (T4), and with Ni-Cr-Co (T2) alloys produced respectively 2.5-fold and 8-fold increases in IL-6 release compared with control cultures. ni-cr-co (t2) 84-97 interleukin 6 Homo sapiens 160-164 16520738-3 2006 Buddlejasaponin IV (2.5-10 microM) reduced lipopolysaccaride (LPS (1 microg ml(-1)))-induced levels of iNOS and COX-2 at the protein levels, and iNOS, COX-2, TNF-alpha, interleukin (IL)-1beta and IL-6 mRNA expression in RAW 264.7 macrophages in a concentration-dependent manner, as determined by Western blotting and RT-PCR, respectively. lipopolysaccaride 43-60 interleukin 6 Homo sapiens 196-200 16864964-10 2007 We found a significant negative correlation between ED and the levels of IL-6 (r = -0.54, p = 0.012). ed 52-54 interleukin 6 Homo sapiens 73-77 17849265-6 2007 In addition, the release of IL-6 was also inhibited by either pyrrolidine dithiocarbamate (PDTC) or NF-kappaB SN50, which are potent NF-kappaB inhibitors. pyrrolidine dithiocarbamic acid 62-89 interleukin 6 Homo sapiens 28-32 17849265-6 2007 In addition, the release of IL-6 was also inhibited by either pyrrolidine dithiocarbamate (PDTC) or NF-kappaB SN50, which are potent NF-kappaB inhibitors. pyrrolidine dithiocarbamic acid 91-95 interleukin 6 Homo sapiens 28-32 16902417-7 2007 Only carboxylic acid-coated QDs significantly increased release of IL-1beta, IL-6, and IL-8. Carboxylic Acids 5-20 interleukin 6 Homo sapiens 77-81 18332612-7 2007 The levels of C-reactive protein and IL-6 increased significantly after 1 or 2 weeks on fosfluconazole in both groups. fosfluconazole 88-102 interleukin 6 Homo sapiens 37-41 18958706-0 2006 Greater than additive suppression of TLR3-induced IL-6 responses by administration of dieldrin and atrazine. Atrazine 99-107 interleukin 6 Homo sapiens 50-54 18958706-6 2006 Subcutaneous administration of dieldrin (10-20 mg/kg, daily for 7 d) and atrazine (one dose on Day 7, 100-200 mg/kg) inhibited the production of IL-6 and IL-12 in the peritoneal cavity in a dose-dependent manner, but IL-10 was either increased or not affected. Atrazine 73-81 interleukin 6 Homo sapiens 145-149 18958706-8 2006 However, at lower dosages of both compounds (10 mg/kg dieldrin and 50 mg/kg atrazine), the effect was much greater than additive on IL-6 production (adding the individual effects of atrazine and dieldrin on IL-6 production indicates 20% suppression, whereas the combination yields 80% suppression) and essentially additive for inhibition of the activation of c-JUN (a component of the transcription factor, AP-1). Atrazine 76-84 interleukin 6 Homo sapiens 207-211 18958706-11 2006 Dieldrin and atrazine administered orally (as opposed to subcutaneously as in the other experiments) also effectively suppressed IL-6 production. Atrazine 13-21 interleukin 6 Homo sapiens 129-133 16945991-5 2006 IL-6 also increased phosphatidylinositol (PI) 3-kinase activity (450%; P < 0.05), which was blunted by subsequent insulin-stimulation (P < 0.05). Phosphatidylinositols 20-40 interleukin 6 Homo sapiens 0-4 16945991-6 2006 IL-6-mediated glucose metabolism was suppressed, but lipid metabolism was unaltered, by inhibition of PI3-kinase with LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 118-126 interleukin 6 Homo sapiens 0-4 17204188-3 2006 The results showed that thalidomide enhanced the proliferations of the CD8+ T, NK cells in PHA-stimulated PBMNC from healthy volunteers, increased the secretion of IL-6 significantly, and decreased the secretion of IFN-gamma, and the secretions of IL-2 and IL-10 were not affected. Thalidomide 24-35 interleukin 6 Homo sapiens 164-168 17204188-5 2006 It is concluded that thalidomide preferentially enhances the proliferations of CD8+ T, NK cells in PHA-stimulated PBMNC from healthy volunteers, and enhances the cytotoxic activity of PBMNC by increasing the secretion of IL-6 significantly, in short, thalidomide can exert anti-myeloma effects by increasing cellular immune function. Thalidomide 21-32 interleukin 6 Homo sapiens 221-225 17204188-5 2006 It is concluded that thalidomide preferentially enhances the proliferations of CD8+ T, NK cells in PHA-stimulated PBMNC from healthy volunteers, and enhances the cytotoxic activity of PBMNC by increasing the secretion of IL-6 significantly, in short, thalidomide can exert anti-myeloma effects by increasing cellular immune function. Thalidomide 251-262 interleukin 6 Homo sapiens 221-225 17723764-6 2006 Under optimal conditions, the current change obtained from the labeled HRP relative to thionine-H2O2 system was proportional to the IL-6 concentration in the range of 5-100 ng L(-1) with a detection limit of 1.0 ng L(-1) (at 3delta). thionine 87-95 interleukin 6 Homo sapiens 132-136 17109502-10 2006 The biliary IL-6 and TNF-alpha levels were positively correlated with serum DBIL, TBA and gamma-GT levels in IHS subjects. tba 82-85 interleukin 6 Homo sapiens 12-16 17065510-10 2006 CONCLUSIONS: IL-6- and VEGF-mediated corneal neovascularization are blocked by TA through the mifepristone-sensitive steroid receptor. Mifepristone 94-106 interleukin 6 Homo sapiens 13-27 16809610-3 2006 EGCG induced both dose- and time-dependent growth arrest and subsequent apoptotic cell death in MM cell lines including IL-6-dependent cells and primary patient cells, without significant effect on the growth of peripheral blood mononuclear cells (PBMCs) and normal fibroblasts. epigallocatechin gallate 0-4 interleukin 6 Homo sapiens 120-124 16775808-2 2006 It has been demonstrated that CKBM is capable of triggering the release of IL-6 and TNFalpha from human peripheral blood mononuclear cells. ckbm 30-34 interleukin 6 Homo sapiens 75-79 16651441-1 2006 We have analyzed in molecular detail how soy isoflavones (genistein, daidzein, and biochanin A) suppress nuclear factor-kappaB (NF-kappaB)-driven interleukin-6 (IL6) expression. Genistein 58-67 interleukin 6 Homo sapiens 146-159 16651441-1 2006 We have analyzed in molecular detail how soy isoflavones (genistein, daidzein, and biochanin A) suppress nuclear factor-kappaB (NF-kappaB)-driven interleukin-6 (IL6) expression. Genistein 58-67 interleukin 6 Homo sapiens 161-164 16572448-8 2006 When hemoglobin, as a scavenger of carbon monoxide, was added to auranofin-treated synovial cell lines, LPS-dependent production of IL-6 and IL-8 was increased. Auranofin 65-74 interleukin 6 Homo sapiens 132-136 16553947-8 2006 Further, glucan phosphate modulated the TSST-1-induced inflammatory response via reduction of IL-1beta and IL-6. glucan phosphate 9-25 interleukin 6 Homo sapiens 107-111 16254130-5 2006 WBH induced an increase in human growth hormone (hGH), ACTH, and cortisol as well as in TNF-alpha, IL-6, IL-8, and IL-12R. wbh 0-3 interleukin 6 Homo sapiens 99-103 16373365-6 2006 Results from reverse transcription-PCR and flow cytometry analysis of HUTEC indicate that the interaction with Daudi cells induce an increased expression of IL-6 and IL-8 mRNA and cell-surface expression of intercellular adhesion molecule-1, all of which were prevented by sodium salicylate, an inhibitor of NF-kappaB activation. Sodium Salicylate 273-290 interleukin 6 Homo sapiens 157-161 16234304-5 2006 Adjusting for age, sex, and major confounders, lower arachidonic and docosahexaenoic acids were associated with significantly higher IL-6 and IL-1ra and significantly lower TGFbeta. arachidonic 53-64 interleukin 6 Homo sapiens 133-137 16234304-8 2006 Total n-3 fatty acids were associated with lower IL-6 (P = 0.005), IL-1ra (P = 0.004), and TNFalpha (P = 0.040) and higher soluble IL-6r (P < 0.001), IL-10 (P = 0.024), and TGFbeta (P = 0.0012). Fatty Acids, Omega-3 6-21 interleukin 6 Homo sapiens 49-53 16234304-12 2006 CONCLUSIONS: In this community-based sample, PUFAs, and especially total n-3 fatty acids, were independently associated with lower levels of proinflammatory markers (IL-6, IL-1ra, TNFalpha, C-reactive protein) and higher levels of antiinflammatory markers (soluble IL-6r, IL-10, TGFbeta) independent of confounders. Fatty Acids, Unsaturated 45-50 interleukin 6 Homo sapiens 166-170 16234304-12 2006 CONCLUSIONS: In this community-based sample, PUFAs, and especially total n-3 fatty acids, were independently associated with lower levels of proinflammatory markers (IL-6, IL-1ra, TNFalpha, C-reactive protein) and higher levels of antiinflammatory markers (soluble IL-6r, IL-10, TGFbeta) independent of confounders. Fatty Acids, Omega-3 73-88 interleukin 6 Homo sapiens 166-170 16299325-7 2005 These findings are consistent with in vitro results showing that production of IL-1beta and IL-6 mRNA and IL-6 protein by human macrophages exposed to mannose-bearing Klebsiella O serotypes is significantly increased by SP-D. Mannose 151-158 interleukin 6 Homo sapiens 92-96 16299325-7 2005 These findings are consistent with in vitro results showing that production of IL-1beta and IL-6 mRNA and IL-6 protein by human macrophages exposed to mannose-bearing Klebsiella O serotypes is significantly increased by SP-D. Mannose 151-158 interleukin 6 Homo sapiens 106-110 16272363-7 2005 According to our results, IL-6 and RANTES levels were abnormally augmented in MG-TEC, either basally or upon induction by adhesion-related stimuli. mg-tec 78-84 interleukin 6 Homo sapiens 26-30 16273650-0 2005 Glutamine-supplemented total parenteral nutrition attenuates plasma interleukin-6 in surgical patients with lower disease severity. Glutamine 0-9 interleukin 6 Homo sapiens 68-81 16273650-12 2005 However, Gln supplementation had a beneficial effect on decreasing systemic IL-6 production after surgery in patients with low admission illness severity, and lower plasma IL-6 may improve nitrogen balance in patients with abdominal surgery when Gln was administered. Glutamine 9-12 interleukin 6 Homo sapiens 76-80 16273650-12 2005 However, Gln supplementation had a beneficial effect on decreasing systemic IL-6 production after surgery in patients with low admission illness severity, and lower plasma IL-6 may improve nitrogen balance in patients with abdominal surgery when Gln was administered. Glutamine 246-249 interleukin 6 Homo sapiens 172-176 16000389-7 2005 Freshly isolated monocytes responded to the PAR-2 AP ASKH 95 (2-furoyl-LIGKV-OH) with the generation of a calcium flux and production of interleukin (IL)-1beta, IL-6, and IL-8. 2-furoyl-leucyl-isoleucyl-glycyl-lysyl-valine 62-79 interleukin 6 Homo sapiens 161-165 16612254-8 2006 There was a stepwise reduction in production of TNF-alpha and IL-6 with increasing doses of diazoxide, hydralazine and furosemide by placentas and PBMCs from these women with normal pregnancies. Hydralazine 103-114 interleukin 6 Homo sapiens 62-66 16612254-9 2006 CONCLUSION: Our data suggest that the antihypertensive drugs clonidine and hydralazine can stimulate production of the circulating anti-inflammatory cytokine IL-10, whereas furosemide and diazoxide inhibit the production of this cytokine and the proinflammatory cytokines TNF-alpha and IL-6 by placentas and PBMCs. Hydralazine 75-86 interleukin 6 Homo sapiens 286-290 16525642-0 2006 Antitumor effects of the novel NF-kappaB inhibitor dehydroxymethyl-epoxyquinomicin on human hepatic cancer cells: analysis of synergy with cisplatin and of possible correlation with inhibition of pro-survival genes and IL-6 production. dehydroxymethylepoxyquinomicin 51-82 interleukin 6 Homo sapiens 219-223 16525642-8 2006 The combination of DHMEQ with cisplatin produced unexpected significant decrease in c-IAP-2 and Bcl-XS mRNAs as well as additive decrease (IL-6, NAIP and, after 16 h, Bcl-XL) or increase (XIAP at 8 h) in gene expression. dehydroxymethylepoxyquinomicin 19-24 interleukin 6 Homo sapiens 139-143 16525642-9 2006 HA22T/VGH produce IL-6; in agreement with the results on mRNA, DHMEQ inhibited such a process. dehydroxymethylepoxyquinomicin 63-68 interleukin 6 Homo sapiens 18-22 16428383-6 2006 Consistent with these data, NEU3 markedly inhibited staurosporine-induced caspase-3 activity and enhanced IL-6-dependent inhibition, which was abolished by LY294002, a PI3K inhibitor. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 156-164 interleukin 6 Homo sapiens 106-110 16157236-6 2005 In addition, DL-homocysteine at the pathophysiologic dose of 25 microg/mL (185 microM) induced mRNA and protein expressions of inflammatory cytokines tumor necrosis factor-alpha, IL-1beta, interleukin-6, interleukin-8, and interleukin-12. DL-Homocysteine 13-28 interleukin 6 Homo sapiens 189-202 16428383-7 2006 Furthermore, IL-6 promoted Rho activation, and the effect was potentiated by NEU3, leading to increased cell motility that was again affected by LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 145-153 interleukin 6 Homo sapiens 13-17 22108347-1 2012 OBJECTIVE: To investigate the inhibitory effects of ursolic acid (UA) on the expression of C-reactive protein (CRP) induced by IL-6 in HepG2 cells and the protective effects on the CRP-induced injury to human umbilical vein endothelial cells (HUVECs). ursolic acid 52-64 interleukin 6 Homo sapiens 127-131 22108347-1 2012 OBJECTIVE: To investigate the inhibitory effects of ursolic acid (UA) on the expression of C-reactive protein (CRP) induced by IL-6 in HepG2 cells and the protective effects on the CRP-induced injury to human umbilical vein endothelial cells (HUVECs). ursolic acid 66-68 interleukin 6 Homo sapiens 127-131 16252694-7 2005 Two-way analysis of variance (ANOVA) showed significant effects of IL6 x ERP interaction on PBM at the total hip (P = 0.019), intertrochanter (P = 0.016), and femoral neck (P =0. pbm 92-95 interleukin 6 Homo sapiens 67-70 22108347-7 2012 RESULT: IL-6 can significantly increase CRP protein and mRNA expression in HepG2 cells, and this effect of IL-6 can be decreased by UA (6.25, 12.5, 25 mumol/L) markedly in a dose-dependent manner. ursolic acid 132-134 interleukin 6 Homo sapiens 107-111 16373999-6 2006 After 90 min recirculation of whole blood, the appearance of IL-6-inducing substances on the blood side was lowest with high-flux PF (1.1 +/- 0.2 ng/ml), slightly higher with low-flux PF (1.9 +/- 0.7 ng/ml) and highest with Cuprophan (4.1 +/- 1 ng/ml). cuprammonium cellulose 224-233 interleukin 6 Homo sapiens 61-65 16123706-9 2005 Taken together, the activation of IL-6 and IL-8 mRNA gene expression may be one of the pathogenesis of zinc oxide-eugenol based and epoxy resin based root canal sealers-induced periapical inflammation. Zinc Oxide 103-113 interleukin 6 Homo sapiens 34-38 22056360-5 2012 We further showed that EGCG reduced production of interferon-gamma, IL-17, IL-6, IL-1beta, and tumor necrosis factor-alpha; decreased types 1 and 17 helper T cells (Th1 and Th17, respectively); and increased regulatory T-cell populations in lymph nodes, the spleen, and the central nervous system. epigallocatechin gallate 23-27 interleukin 6 Homo sapiens 75-79 15967875-0 2005 Thromboxane A2 promotes interleukin-6 biosynthesis mediated by an activation of cyclic AMP-response element-binding protein in 1321N1 human astrocytoma cells. Thromboxane A2 0-14 interleukin 6 Homo sapiens 24-37 16046706-0 2005 Palmitate activates the NF-kappaB transcription factor and induces IL-6 and TNFalpha expression in 3T3-L1 adipocytes. Palmitates 0-9 interleukin 6 Homo sapiens 67-71 16046706-5 2005 Palmitate, but not DHA or laurate, induced nuclear factor kappaB (NF-kappaB)-driven luciferase activity and interleukin-6 (IL-6) expression (P < 0.05). Palmitates 0-9 interleukin 6 Homo sapiens 108-121 16317391-8 2005 GLN treatment increased MKP-1 peptide expression and significantly attenuated TNF-alpha and IL-6 6 h after CLP. Glutamine 0-3 interleukin 6 Homo sapiens 92-96 19758923-6 2005 CONCLUSION: After PCI in UA, cyclooxygenase-2 inhibitor rofecoxib added to atorvastatin reduced CRP and IL-6 levels more profoundly than atorvastatin alone at 3- and 6-month after intervention. rofecoxib 56-65 interleukin 6 Homo sapiens 104-108 16211268-0 2005 UV-induced NF-kappaB activation and expression of IL-6 is attenuated by (-)-epigallocatechin-3-gallate in cultured human keratinocytes in vitro. epigallocatechin gallate 72-102 interleukin 6 Homo sapiens 50-54 16046706-5 2005 Palmitate, but not DHA or laurate, induced nuclear factor kappaB (NF-kappaB)-driven luciferase activity and interleukin-6 (IL-6) expression (P < 0.05). Palmitates 0-9 interleukin 6 Homo sapiens 123-127 22613992-13 2012 Tryptase also activated NF-kappa B within 30 min, and ammonium pyrrolidinedithiocarbamate, an inhibitor of NF- kappa B, reduced tryptase-induced TNF-alpha and IL-6 release. pyrrolidine dithiocarbamic acid 54-89 interleukin 6 Homo sapiens 159-163 16046706-6 2005 Inhibition of fatty acyl Co-A synthase (FACS) with triacsin C suppressed palmitate-induced NF-kappaB activation (P < 0.05), but caused an additive increase in palmitate-induced IL-6 expression (P < 0.05). Palmitates 162-171 interleukin 6 Homo sapiens 180-184 16046706-7 2005 Disrupting mitogen-activated protein kinase/Erk kinase (MEK) and protein kinase C (PKC) activity with U0126 and Bisindolylmaleimide (Bis), respectively, suppressed palmitate-induced IL-6 expression (P < 0.05), but had no effect on NF-kappaB reporter gene activity (P > 0.05). Palmitates 164-173 interleukin 6 Homo sapiens 182-186 16344099-5 2005 First established as agents with antiangiogenic properties, thalidomide and IMiDs inhibit the production of interleukin (IL)-6, which is a growth factor for the proliferation of myeloma cells. Thalidomide 60-71 interleukin 6 Homo sapiens 108-126 15913932-7 2005 Increased IL-6 production was partially inhibited by treatment of iron (HIF-1 inhibitor) or pyrriolidine-dithiocarbamate (PDTC, NF-kappaB inhibitor). pyrriolidine-dithiocarbamate 92-120 interleukin 6 Homo sapiens 10-14 16077397-8 2005 Rolipram inhibited the increase in C4d fragment and interleukin-6, but it did not affect the increase in Bb fragment or C5b-9. Rolipram 0-8 interleukin 6 Homo sapiens 52-65 22110547-5 2012 In addition, EBNE-induced proliferation was found to be mediated through the production of IL-6 and VEGF, which was induced by activation of AP-1 and NF-kappaB. ebne 13-17 interleukin 6 Homo sapiens 91-95 16077397-9 2005 CONCLUSION: Rolipram inhibited changes in adhesion molecule expression and interleukin-6 release by activated monocytes in simulated extracorporeal circulation. Rolipram 12-20 interleukin 6 Homo sapiens 75-88 15914040-8 2005 RESULTS: PE-TCs produced significantly more IL-6, IL-8, and IL-10 than those of normal-TCs when they were cultured under normoxic condition, P < .05. 9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide 12-15 interleukin 6 Homo sapiens 44-48 15914040-9 2005 Both normal-TCs and PE-TCs produced more IL-6 and IL-8 when they were cultured under hypoxic conditions. 9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide 12-15 interleukin 6 Homo sapiens 41-45 15914040-9 2005 Both normal-TCs and PE-TCs produced more IL-6 and IL-8 when they were cultured under hypoxic conditions. pe 20-22 interleukin 6 Homo sapiens 41-45 22110547-7 2012 In addition, EBNE-induced production of IL-6 and VEGF was inhibited by PD98059 (a p44/42 MAPK inhibitor), SB203580 (a p38 MAPK inhibitor), and PDTC (a NF-kappaB inhibitor), but not SP600125 (a JNK inhibitor). ebne 13-17 interleukin 6 Homo sapiens 40-44 15914040-9 2005 Both normal-TCs and PE-TCs produced more IL-6 and IL-8 when they were cultured under hypoxic conditions. 9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide 23-26 interleukin 6 Homo sapiens 41-45 15956716-4 2005 Relaxin blunted the endotoxin-induced production of inflammatory cytokines (interleukin 1 [IL-1], IL-6, and tumor necrosis factor- alpha) by human macrophages, an effect that was suppressed by the GR antagonist RU-486. Mifepristone 211-217 interleukin 6 Homo sapiens 98-136 22110547-9 2012 Taken together, these findings suggest that the EBNE-induced proliferation of hADSCs primarily occurs through increased expression of IL-6 and VEGF genes, which is mediated by the activation of NF-kappaB and AP-1 through p44/42 MAPK and p38 MAPK. ebne 48-52 interleukin 6 Homo sapiens 134-138 22235107-8 2012 Interleukin-6 increased in all groups except the GLN group. Glutamine 49-52 interleukin 6 Homo sapiens 0-13 15561952-0 2004 Palmitate-induced interleukin-6 expression in human coronary artery endothelial cells. Palmitates 0-9 interleukin 6 Homo sapiens 18-31 15561952-5 2004 Palmitate, but not linoleate, induced a significant increase in IL-6 mRNA expression in CAECs (P < 0.001) and, to a less relevant extent, in CASMCs (P < 0.01). Palmitates 0-9 interleukin 6 Homo sapiens 64-68 16061877-3 2005 The inhibitory effects of DHMEQ on IL-6 secretion and cachexia were investigated in in vitro and in vivo studies using JCA-1 cells derived from human prostate cancer. dehydroxymethylepoxyquinomicin 26-31 interleukin 6 Homo sapiens 35-39 16061877-5 2005 IL-6 secretion was significantly inhibited in JCA-1 cells exposed to DHMEQ. dehydroxymethylepoxyquinomicin 69-74 interleukin 6 Homo sapiens 0-4 16061877-8 2005 CONCLUSIONS: These results suggested an association between serum IL-6 and cachexia in patients with prostate cancer and in JCA-1 tumor-bearing mice and that a new NF-kappaB inhibitor, DHMEQ, could prevent the development of cachexia in JCA-1 tumor-bearing mice presumably through the inhibition of IL-6 secretion. dehydroxymethylepoxyquinomicin 185-190 interleukin 6 Homo sapiens 66-70 15561952-9 2004 IL-6 levels correlated with palmitate, but not with other abundant FFAs, even after adjusting for body fat (r = 0.33, P < 0.05) and total FFAs (r = 0.29, P < 0.05). Palmitates 28-37 interleukin 6 Homo sapiens 0-4 21659904-6 2012 RESULTS: Change in interleukin-6 was significantly reduced in NAB compared with PL immediately after the race (median (interquartile range) = 23.9 (15.9-38.7) vs 31.6 (18.5-53.3) ng L(-1), P = 0.03). nab 62-65 interleukin 6 Homo sapiens 19-32 15561952-10 2004 We show here that the common plasma FFA palmitate induces high levels of IL-6 in CAECs. Palmitates 40-49 interleukin 6 Homo sapiens 73-77 15579524-10 2004 Synthetic cytosine-guanosine dinucleotide-containing ODN were able to induce IL-6 in human mononuclear cells. cytosine-guanosine dinucleotide 10-41 interleukin 6 Homo sapiens 77-81 16101668-7 2005 Exposure to CRLP containing 7beta-hydroxysterol, but not to CRLP or 7-ketosterol-containing CRLP, reduced IL-6 secretion with respect to cells not exposed to any particles. 7beta-hydroxysterol 28-47 interleukin 6 Homo sapiens 106-110 23087143-0 2012 Epigallocatechin-3-gallate inhibits angiotensin II and interleukin-6-induced C-reactive protein production in macrophages. epigallocatechin gallate 0-26 interleukin 6 Homo sapiens 55-68 15966973-2 2005 Ah-2743 caused significantly higher serum levels of tumour necrosis factor-alpha, interleukin (IL)-1beta or IL-6 in human whole blood, and higher serum IL-1beta and IL-6 levels in infected mice, than did Kp-129 and E. coli ATCC 25922. ah-2743 0-7 interleukin 6 Homo sapiens 108-112 23087143-4 2012 Therefore, the effect of EGCG on angiotensin II (Ang II)- and interleukin-6 (IL-6)-induced CRP production in U937 macrophages and the possible mechanisms were observed. epigallocatechin gallate 25-29 interleukin 6 Homo sapiens 62-75 15966973-2 2005 Ah-2743 caused significantly higher serum levels of tumour necrosis factor-alpha, interleukin (IL)-1beta or IL-6 in human whole blood, and higher serum IL-1beta and IL-6 levels in infected mice, than did Kp-129 and E. coli ATCC 25922. ah-2743 0-7 interleukin 6 Homo sapiens 165-169 15507476-7 2004 Cell viability measurements were based on release of LDH from cell cytosol, and synthesis of IL-6 and proliferation after exposure to GDP. Guanosine Diphosphate 134-137 interleukin 6 Homo sapiens 93-97 15507476-13 2004 GDP-high PDF but not GDP-free PDF reduced synthesis of IL-6 in mesothelial cells by 40% (P < 0.01) an effect that was reversed by OTZ. Guanosine Diphosphate 0-3 interleukin 6 Homo sapiens 55-59 15930285-8 2005 However, when zebularine is withdrawn from the cells, the reestablishment of the original CpG island methylation within the p53 promoter does not occur in the absence of IL-6, and cells which do not receive IL-6 eventually die, as p53 expression continues unchecked by remethylation. pyrimidin-2-one beta-ribofuranoside 14-24 interleukin 6 Homo sapiens 207-211 23087143-4 2012 Therefore, the effect of EGCG on angiotensin II (Ang II)- and interleukin-6 (IL-6)-induced CRP production in U937 macrophages and the possible mechanisms were observed. epigallocatechin gallate 25-29 interleukin 6 Homo sapiens 77-81 15930285-10 2005 Consistent with this model, when cells that express IL-6 in an autocrine fashion are subjected to identical treatment, p53 expression is reduced shortly after withdrawal of zebularine. pyrimidin-2-one beta-ribofuranoside 173-183 interleukin 6 Homo sapiens 52-56 15638042-6 2004 RESULTS: Production of the secretedforms of IL-1beta and IL-6 was inhibited by TauCl with IC50 approximately equal to 250 microM and 300-400 microM respectively, in all investigated groups. taucl 79-84 interleukin 6 Homo sapiens 57-61 23087143-9 2012 RESULTS: Pretreatment of macrophages with EGCG prior to the stimulation concentration-dependently inhibited Ang II- and IL-6-induced expression of CRP both in protein and mRNA levels. epigallocatechin gallate 42-46 interleukin 6 Homo sapiens 120-124 15299003-3 2004 Our results show that upon activation of the ryanodine receptor (RYR), myotubes release interleukin-6 (IL-6); this was dependent on de novo protein synthesis and could be blocked by dantrolene and cyclosporine. Dantrolene 182-192 interleukin 6 Homo sapiens 88-101 23087143-10 2012 Meanwhile, EGCG reduced Ang II- and IL-6-stimulated generation of ROS in macrophages. epigallocatechin gallate 11-15 interleukin 6 Homo sapiens 36-40 15299003-3 2004 Our results show that upon activation of the ryanodine receptor (RYR), myotubes release interleukin-6 (IL-6); this was dependent on de novo protein synthesis and could be blocked by dantrolene and cyclosporine. Dantrolene 182-192 interleukin 6 Homo sapiens 103-107 16130059-3 2005 In the present study, the authors aimed to compare the effects of ketamine anesthesia and isoflurane anesthesia with respect to serum and tracheobronchial aspirate (TBA) IL-6 levels in infants undergoing CPB for cardiac surgery. Isoflurane 90-100 interleukin 6 Homo sapiens 170-174 23087143-11 2012 CONCLUSION: EGCG is able to inhibit Ang II- and IL-6-stimulated CRP expression in macrophages to produce an anti-inflammation by interfering with ROS generation. epigallocatechin gallate 12-16 interleukin 6 Homo sapiens 48-52 15613495-3 2005 Stretch-induced IKK activation and IL-6 secretion were inhibited by application of alpha(5)beta(1) integrin-inhibitory peptide (GRGDNP), phosphatidylinositol 3-kinase inhibitor (LY-294002), phospholipase C-gamma inhibitor (U-73122), or protein kinase C inhibitor (H7). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 178-187 interleukin 6 Homo sapiens 35-39 21917559-2 2011 Pyrrolidine dithiocarbamate (PDTC) antagonizes the cellular responsiveness to IL-6 through impairment in signal transducer and activator of transcription-3 activation and downstream signaling. pyrrolidine dithiocarbamic acid 0-27 interleukin 6 Homo sapiens 78-82 15935883-9 2005 We conclude that DCI3 are endowed with the property of regulating the suppressive effect of regulatory T cells through high IL-6 production. dci3 17-21 interleukin 6 Homo sapiens 124-128 15618163-9 2005 The upregulation of ICAM-1, IL-6, and IL-8 was completely inhibited by pretreating the cells with an NF-kappaB activation inhibitor, l-1-tosylamido-2-phenylethyl chloromethyl ketone. Tosylphenylalanyl Chloromethyl Ketone 133-181 interleukin 6 Homo sapiens 28-32 15289446-4 2004 Relaxin blunted the endotoxin-induced production of inflammatory cytokines (IL-1, IL-6, TNF-alpha) by human macrophages--an effect that was suppressed by the GR antagonist RU-486. Mifepristone 172-178 interleukin 6 Homo sapiens 82-86 21917559-2 2011 Pyrrolidine dithiocarbamate (PDTC) antagonizes the cellular responsiveness to IL-6 through impairment in signal transducer and activator of transcription-3 activation and downstream signaling. pyrrolidine dithiocarbamic acid 29-33 interleukin 6 Homo sapiens 78-82 15377473-9 2004 The presence of the RANK-Fc that blocks the RANK/RANKL interaction significantly inhibited HMCL-induced secretion of IL-6 and IL-11. hmcl 91-95 interleukin 6 Homo sapiens 117-121 16173059-3 2005 TRPV1 antagonists and reduction of calcium concentrations in treatment solutions attenuated calcium flux, induction of interleukin-6 and 8 gene expression, and IL-6 secretion by cells treated with capsaicin or resiniferatoxin. resiniferatoxin 210-225 interleukin 6 Homo sapiens 119-138 21506956-8 2011 Celastrol also inhibited both the constitutive and IL6-induced activation of STAT3, which induced apoptosis as indicated by an increase in the accumulation of cells in the sub-G1 phase, an increase in the expression of pro-apoptotic proteins and activation of caspase-3. celastrol 0-9 interleukin 6 Homo sapiens 51-54 16173059-3 2005 TRPV1 antagonists and reduction of calcium concentrations in treatment solutions attenuated calcium flux, induction of interleukin-6 and 8 gene expression, and IL-6 secretion by cells treated with capsaicin or resiniferatoxin. resiniferatoxin 210-225 interleukin 6 Homo sapiens 160-164 16173061-3 2005 Cells overexpressing interleukin 10 suppressed the pro-inflammatory cytokines interleukin 8 and interleukin 6 following exposure to 50-300 microM sulfur mustard. Mustard Gas 146-160 interleukin 6 Homo sapiens 96-109 16173061-5 2005 On the other hand, cells overexpressing tumor necrosis factor alpha induced a sustained elevation in both interleukin 6 and 8 expression following exposure to 50-300 microM sulfur mustard. Mustard Gas 173-187 interleukin 6 Homo sapiens 106-125 15569326-8 2004 After lipopolysaccaride stimulation, monocyte production of IL-1beta, TNF-alpha, and IL-6 in ARF patients was reduced by 41%, 84%, and 45%, respectively, compared to healthy subjects (P < 0.01 in each case), and similarly reduced compared to CKD and ESRD patients, and were similar to CRIT ILL patients. lipopolysaccaride 6-23 interleukin 6 Homo sapiens 85-89 15223630-5 2004 Second, we suggest some molecular pathways involving cytokines produced by HD-derived fibroblasts (SCF, IL-7, IL-6) supposedly responsible for H-RS proliferation and rescue from apoptosis. h-rs 143-147 interleukin 6 Homo sapiens 110-114 21733605-9 2011 RESULTS: There was no difference between groups in frequency and severity of diarrhoea during radiochemotherapy (p = 0.5 and p = 0.39 respectively), insulin levels significantly increased in both groups, IL-6 only in glutamine group. Glutamine 217-226 interleukin 6 Homo sapiens 204-208 15302800-6 2004 Rofecoxib compared with placebo also lowered IL-6 at 6 months (P=0.0002). rofecoxib 0-9 interleukin 6 Homo sapiens 45-49 15302800-7 2004 There was a significant off-drug effect on CRP and IL-6 levels in the rofecoxib group 3 months after treatment (P=0.005 and P=0.009, respectively). rofecoxib 70-79 interleukin 6 Homo sapiens 51-55 15586558-6 2004 Macrolides inhibit the production of many proinflammatory cytokines, such as interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor-alpha, perhaps by suppressing the transcription factor nuclear factor-kappaB or activator protein-1. Macrolides 0-10 interleukin 6 Homo sapiens 97-101 15489490-8 2004 CONCLUSIONS: The concentration of fibrogenic (bFGF) and inflammatory (IL-6) growth factors and protein is raised in retro-silicone oil fluid. Silicone Oils 122-134 interleukin 6 Homo sapiens 70-74 15315713-7 2004 Similarly, IL-6 and IL-6r were highly correlated with PaO2/FiO2 (r = -0.27, p < 0.05 and r = -0.55, p < 0.0001, respectively). fio2 59-63 interleukin 6 Homo sapiens 11-15 21861859-4 2011 In a recent study, epigallocatechin-3-gallate, a green tea polyphenol, was found to be effective in reducing IL-1beta-induced inflammatory cytokines, TNFalpha, IL-6, granulocyte-macrophage colony-stimulating factor and several chemokines from human chondrocytes. epigallocatechin gallate 19-45 interleukin 6 Homo sapiens 160-164 15240713-7 2004 Stimulation of the above-mentioned cells with bacterial DNA or CpG oligodeoxynucleotide resulted in an inflammatory reaction characterized by a dose-dependent up-regulation of cytokines (IL-6, IL-8) and human beta-defensin 2. Oligodeoxyribonucleotides 67-87 interleukin 6 Homo sapiens 187-191 15534490-1 2004 Subcutaneous injection of normal human volunteers with a B-class CpG oligodeoxynucleotide (ODN) TLR9 agonist, CPG 7909, induced a TH1-like pattern of systemic innate immune activation manifested by expression of IL-6, IL-12p40, IFN-alpha, and IFN-inducible chemokines. Oligodeoxyribonucleotides 69-89 interleukin 6 Homo sapiens 212-216 15534490-1 2004 Subcutaneous injection of normal human volunteers with a B-class CpG oligodeoxynucleotide (ODN) TLR9 agonist, CPG 7909, induced a TH1-like pattern of systemic innate immune activation manifested by expression of IL-6, IL-12p40, IFN-alpha, and IFN-inducible chemokines. Oligodeoxyribonucleotides 91-94 interleukin 6 Homo sapiens 212-216 15526907-7 2004 Furthermore, troglitazone downregulated TNF-alpha and IL-6 mRNA expression from IL-1beta challenge HMCLs. hmcls 99-104 interleukin 6 Homo sapiens 54-58 21657246-10 2011 Of particular importance is that the genistein-modified blend membranes (PA:PVP/G) showed greater suppression of the concentrations of all three cytokines (TNF-alpha, IL-1beta, and IL-6) in comparison with those of the PA/G membranes, signifying the role of PVP in the enhanced anti-inflammatory properties of these genistein-modified membranes. Genistein 37-46 interleukin 6 Homo sapiens 181-185 15197140-9 2004 Interleukin-6 (P=0.04) and C-reactive protein (P=0.02) decreased more in the repaglinide group than in the glyburide group. Glyburide 107-116 interleukin 6 Homo sapiens 0-13 15532722-8 2004 Both the fever and the increased levels of IL-1beta, IL-6, and TNF-alpha in supernatant fluids obtained from the SEA-stimulated PBMC were decreased by incubating SEA-PBMC with either PDTC, Pyri, NAC, or Cur. pyrrolidine dithiocarbamic acid 183-187 interleukin 6 Homo sapiens 53-57 21633597-0 2011 (-)-Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 via Stat3 in gastric cancer. epigallocatechin gallate 0-30 interleukin 6 Homo sapiens 67-71 15028733-0 2004 Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB. Palmitates 0-9 interleukin 6 Homo sapiens 70-83 15028733-4 2004 We demonstrate that specifically saturated FFAs, e.g. palmitate (0.25 mm), induce IL-6 mRNA expression and protein secretion by a proteasome-dependent mechanism that leads to a rapid and chronic activation of nuclear factor-kappaB. Palmitates 54-63 interleukin 6 Homo sapiens 82-86 15028733-6 2004 In fact, the unsaturated FFA linoleate inhibited palmitate-induced IL-6 production. Palmitates 49-58 interleukin 6 Homo sapiens 67-71 15226473-7 2004 Total (n-3) fatty acids had an inverse relation with CRP (beta = -0.44, P = 0.007), IL-6 (beta = -0.26, P = 0.009), E-selectin (beta = -0.17, P = 0.004), sICAM-1 (beta = -0.07, P = 0.02), and sVCAM-1 (beta = -0.10, P = 0.004). Fatty Acids, Omega-3 6-23 interleukin 6 Homo sapiens 84-88 21633597-1 2011 AIM: To demonstrate that (-)-Epigallocatechin-3-gallate (EGCG) inhibits vascular endothelial growth factor (VEGF) expression and angiogenesis induced by interleukin-6 (IL-6) via suppressing signal transducer and activator of transcription 3 (Stat3) activity in gastric cancer. epigallocatechin gallate 25-55 interleukin 6 Homo sapiens 153-166 15316216-11 2004 Stimulation with CS resulted in upregulation of mRNA for IL-6 and IL-8 and protein release. Cesium 17-19 interleukin 6 Homo sapiens 57-61 21633597-1 2011 AIM: To demonstrate that (-)-Epigallocatechin-3-gallate (EGCG) inhibits vascular endothelial growth factor (VEGF) expression and angiogenesis induced by interleukin-6 (IL-6) via suppressing signal transducer and activator of transcription 3 (Stat3) activity in gastric cancer. epigallocatechin gallate 25-55 interleukin 6 Homo sapiens 168-172 21633597-1 2011 AIM: To demonstrate that (-)-Epigallocatechin-3-gallate (EGCG) inhibits vascular endothelial growth factor (VEGF) expression and angiogenesis induced by interleukin-6 (IL-6) via suppressing signal transducer and activator of transcription 3 (Stat3) activity in gastric cancer. epigallocatechin gallate 57-61 interleukin 6 Homo sapiens 153-166 21633597-1 2011 AIM: To demonstrate that (-)-Epigallocatechin-3-gallate (EGCG) inhibits vascular endothelial growth factor (VEGF) expression and angiogenesis induced by interleukin-6 (IL-6) via suppressing signal transducer and activator of transcription 3 (Stat3) activity in gastric cancer. epigallocatechin gallate 57-61 interleukin 6 Homo sapiens 168-172 15194169-5 2004 Induction of these autoantibodies appeared to be associated with the hydrocarbon"s ability to induce IL-12, IL-6, and TNF-alpha, suggesting a relationship with hydrocarbon"s adjuvanticity. Hydrocarbons 69-80 interleukin 6 Homo sapiens 108-112 21315154-4 2011 Three of the four tested macrolides, azithromycin, clarithromycin and roxithromycin, exhibited pronounced, concentration-related reduction of IL-1beta, IL-6, IL-10, TNF-alpha, CCL3, CCL5, CCL20, CCL22, CXCL1, CXCL5, and G-CSF release. Roxithromycin 70-83 interleukin 6 Homo sapiens 152-156 15046772-0 2004 Monophthalates promote IL-6 and IL-8 production in the human epithelial cell line A549. monophthalates 0-14 interleukin 6 Homo sapiens 23-27 21782718-0 2004 Neutralization effects of interleukin-6 (IL-6) antibodies on sulfur mustard (HD)-induced IL-6 secretion on human epidermal keratinocytes. Mustard Gas 61-75 interleukin 6 Homo sapiens 26-39 21782718-0 2004 Neutralization effects of interleukin-6 (IL-6) antibodies on sulfur mustard (HD)-induced IL-6 secretion on human epidermal keratinocytes. Mustard Gas 61-75 interleukin 6 Homo sapiens 41-45 21782718-0 2004 Neutralization effects of interleukin-6 (IL-6) antibodies on sulfur mustard (HD)-induced IL-6 secretion on human epidermal keratinocytes. Mustard Gas 61-75 interleukin 6 Homo sapiens 89-93 21782718-1 2004 The proinflammatory cytokine human interleukin-6 (hIL-6) plays an important role in the early and late courses of inflammation, trauma, and wound healing caused by sulfur mustard (HD). Mustard Gas 164-178 interleukin 6 Homo sapiens 35-48 21166654-2 2011 PI3K inhibitor, LY294002 significantly reduced IL-1beta-induced IL-6 production in A549 cells but not in RASF, indicating that IL-1beta-induced IL-6 production was partially mediated by PI3Kin A549 cells but not in RASF. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 16-24 interleukin 6 Homo sapiens 64-68 21782718-1 2004 The proinflammatory cytokine human interleukin-6 (hIL-6) plays an important role in the early and late courses of inflammation, trauma, and wound healing caused by sulfur mustard (HD). Mustard Gas 164-178 interleukin 6 Homo sapiens 50-55 15118463-7 2004 RESULTS: Latanoprost, pilocarpine-HCl, and timolol-maleate increased IL-6 levels in the conditioned medium in a dilution factor-dependent manner (P < 0.05, ANOVA). Pilocarpine 22-37 interleukin 6 Homo sapiens 69-73 20717763-12 2011 IL-6 up-regulated the levels of phosphorylated STAT3 and Akt, and this was blocked by AG490 and LY294002, respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 96-104 interleukin 6 Homo sapiens 0-4 15136366-0 2004 Rofecoxib, a COX-2 inhibitor, lowers C-reactive protein and interleukin-6 levels in patients with acute coronary syndromes. rofecoxib 0-9 interleukin 6 Homo sapiens 60-73 15136366-2 2004 AIM: To evaluate whether patients with ACS treated with rofecoxib, a COX-2 inhibitor, will have reduced CRP, IL-6, and soluble tumor necrotic factor receptor-1 (sTNF-R1) levels and improved endothelial function. rofecoxib 56-65 interleukin 6 Homo sapiens 109-113 15136366-6 2004 IL-6 levels were significantly lower at 1 month (p < 0.02) in the rofecoxib group, but not at 3 months. rofecoxib 69-78 interleukin 6 Homo sapiens 0-4 15136366-8 2004 CONCLUSION: Patients recovering from ACS had lower levels of CRP and IL-6 at 1 month and lower CRP levels at 3 months when treated with rofecoxib plus aspirin. rofecoxib 136-145 interleukin 6 Homo sapiens 69-73 14644994-6 2004 Importantly, GW654652 also inhibits interleukin-6 and VEGF secretion and proliferation of MM cells induced by tumor cell binding to bone marrow (BM) stromal cells. GW 654652 13-21 interleukin 6 Homo sapiens 36-49 15209354-3 2004 TNF-alpha and IL-6 were significantly increased in a CKBM dose- and time-dependent manner. ckbm 53-57 interleukin 6 Homo sapiens 14-18 15209354-6 2004 The current study indicated that CKBM may modulate the immune response by inducing the secretions of TNF-alpha and IL-6, which are cytokine mediators of innate immunity and inflammation preparing or "priming" the body to combat diseases. ckbm 33-37 interleukin 6 Homo sapiens 115-119 21547675-5 2011 Our results imply that the inhibitory activity of IL-6 production in TNF-alpha-stimulated MG-63 cell may be affected by the presence of C-4" hydroxyl group in the chalcone moiety. Chalcone 163-171 interleukin 6 Homo sapiens 50-54 15041589-0 2004 Xenon and isoflurane differentially modulate lipopolysaccharide-induced activation of the nuclear transcription factor KB and production of tumor necrosis factor-alpha and interleukin-6 in monocytes. Isoflurane 10-20 interleukin 6 Homo sapiens 172-185 15041589-8 2004 In contrast, isoflurane inhibited the activation of NF-kappaB, which was associated with a decreased production of TNF-alpha and IL-6. Isoflurane 13-23 interleukin 6 Homo sapiens 129-133 15041589-9 2004 Our results demonstrate that xenon and isoflurane have opposite effects on the LPS-induced production of TNF-alpha and IL-6. Isoflurane 39-49 interleukin 6 Homo sapiens 119-123 15182131-4 2004 Considering the involvement of IL-6 in Castleman"s disease we treated the patient with thalidomide obtaining the remission of the nephrotic syndrome. Thalidomide 87-98 interleukin 6 Homo sapiens 31-35 21187140-5 2011 The results showed that NE and isoproterenol significantly enhanced IL-6 mRNA expression and protein production in supernatants of SCC9 and SCC25 cells. Isoproterenol 31-44 interleukin 6 Homo sapiens 68-72 15051604-9 2004 TFA intake was not associated with IL-6 or CRP concentrations overall but was positively associated with IL-6 and CRP in women with higher body mass index (P for interaction = 0.03 for each). Trans Fatty Acids 0-3 interleukin 6 Homo sapiens 105-109 15041589-10 2004 Furthermore, xenon increases, whereas isoflurane inhibits the activation of NF-kappaB, providing a possible molecular mechanism for the different effects on monocyte TNF-alpha and IL-6 production. Isoflurane 38-48 interleukin 6 Homo sapiens 180-184 21187140-6 2011 Physiological stress levels of NE and isoproterenol (10 muM) at 1 h elicited the most robust IL-6 increase. Isoproterenol 38-51 interleukin 6 Homo sapiens 93-97 14551144-9 2004 We show that in mature PDCs adenosine reduces interleukin-6 (IL-6), IL-12, and IFN-alpha production in response to CpG oligodeoxynucleotides (ODN). Oligodeoxyribonucleotides 119-140 interleukin 6 Homo sapiens 61-65 20822828-5 2011 Kyn/trp correlated strongly with concentrations of cytokine IL-6, of soluble interleukin-2 receptor-alpha and 75 kDa TNF-alpha receptor and of the macrophage marker neopterin (all p<0.001 or p<0.01) but not with TNF-alpha. Kynurenine 0-3 interleukin 6 Homo sapiens 60-64 15055740-7 2004 A significantly higher production of IL-6 was found in both unstimulated and stimulated PBL from heroin addicts and patients maintained on methadone, when compared with PBL from healthy controls. Pentane-2,2,4,4-Tetrol 88-91 interleukin 6 Homo sapiens 37-41 14977303-6 2004 However, LPS stimulated IL-6 production, and this production was augmented when CH3SH was present. methylmercaptan 80-85 interleukin 6 Homo sapiens 24-28 14977303-7 2004 We conclude that the volatile sulfur compound CH3SH plays a role in activation and modulation of the immune response through its role in production of IL-6. methylmercaptan 46-51 interleukin 6 Homo sapiens 151-155 14688319-6 2004 Furthermore, NK cells respond to poly(I:C) by producing proinflammatory cytokines like IL-6 and IL-8, as well as the antiviral cytokine IFN-gamma. poly 33-37 interleukin 6 Homo sapiens 87-91 20466551-8 2011 Significant correlations were found between intraarticular IL-6 concentrations and KSS and WOMAC scores at the first month according to the Pearson correlation test, but no correlations were found between serum IL-6 and CRP levels and KSS and WOMAC scores. womac 91-96 interleukin 6 Homo sapiens 59-63 14615256-2 2003 The aim of this study was to evaluate the effect of the calcium antagonist verapamil on the interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) secretion, as well as on cellular growth, in primary cultures of fibroblasts derived from the central part of keloid lesions. Verapamil 75-84 interleukin 6 Homo sapiens 92-105 14615256-2 2003 The aim of this study was to evaluate the effect of the calcium antagonist verapamil on the interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) secretion, as well as on cellular growth, in primary cultures of fibroblasts derived from the central part of keloid lesions. Verapamil 75-84 interleukin 6 Homo sapiens 107-111 14615256-5 2003 Verapamil (100 microM) decreased IL-6 and VEGF production (P<0.03 and P<0.005, respectively) in central keloid fibroblasts cultures at 72 h. Moreover, verapamil decreased cellular proliferation by 29% and increased apoptosis to an absolute value of 8%. Verapamil 0-9 interleukin 6 Homo sapiens 33-37 14615256-6 2003 The results of this study demonstrate that in primary cultures of central keloid fibroblasts verapamil reduces the sustained basal IL-6 and VEGF production and inhibits cell growth; these data may offer the link with the beneficial effect of calcium antagonists on keloid scars in vivo. Verapamil 93-102 interleukin 6 Homo sapiens 131-135 14638469-2 2003 Moxifloxacin inhibited the production of tumor necrosis factor alpha (TNF-alpha) and/or interleukin-6 (IL-6) by PBMCs stimulated with lipopolysaccharide (LPS), lipoteichoic acid (LTA), and heat-killed bacteria in a concentration-dependent manner without cytotoxic effects. Moxifloxacin 0-12 interleukin 6 Homo sapiens 88-101 14638469-2 2003 Moxifloxacin inhibited the production of tumor necrosis factor alpha (TNF-alpha) and/or interleukin-6 (IL-6) by PBMCs stimulated with lipopolysaccharide (LPS), lipoteichoic acid (LTA), and heat-killed bacteria in a concentration-dependent manner without cytotoxic effects. Moxifloxacin 0-12 interleukin 6 Homo sapiens 103-107 14638469-3 2003 The addition of moxifloxacin reduced the population of cells positive for CD-14 and TNF-alpha and for CD-14 and IL-6 among the LPS- or LTA-stimulated PBMCs. Moxifloxacin 16-28 interleukin 6 Homo sapiens 112-116 21164517-2 2011 We investigated the effects of a novel small-molecule JAK inhibitor (AZD1480) on IL-6/JAK signal transduction and its biological consequences on the human myeloma-derived cell lines U266 and Kms.11. AZD 1480 69-76 interleukin 6 Homo sapiens 81-85 12876073-0 2003 Increased expression of TNF-alpha, IL-6, and IL-8 in HALS: implications for reduced adiponectin expression and plasma levels. Fluoxymesterone 53-57 interleukin 6 Homo sapiens 35-39 12876073-8 2003 AT mRNA of TNF-alpha, IL-6, and IL-8 was increased in AT of HALS subjects (P < 0.05), and both AT TNF-alpha mRNA and plasma TNF-alpha were negatively correlated to plasma adiponectin (P < 0.05). Fluoxymesterone 60-64 interleukin 6 Homo sapiens 22-26 14533000-0 2003 N-3 fatty acid-rich diet prevents early response of interleukin-6 elevation in trinitrobenzene sulfonic acid-induced enteritis. Fatty Acids, Omega-3 0-14 interleukin 6 Homo sapiens 52-65 14533000-10 2003 Serum IL-6 levels were significantly higher in the n-6 fatty acid-rich diet group than in the n-3 fatty acid-rich group (P<0.05). Fatty Acids, Omega-3 94-108 interleukin 6 Homo sapiens 6-10 14533000-13 2003 The effects of the n-3 fatty acids were associated with blockage of mucosal IL-6 secretion. Fatty Acids, Omega-3 19-34 interleukin 6 Homo sapiens 76-80 14636727-11 2003 The extent of STT was correlated best to IL-8 (r=0.75), IL-6 (r=0.54), and creatine kinase (CK, r=0.49) plasma concentrations. SCHEMBL22553698 14-17 interleukin 6 Homo sapiens 56-60 14523996-1 2003 In recent studies, sodium arsenite (SA) inhibited IL-6 production in cultured intestinal epithelial cells, at least in part by downregulating the activity of nuclear factor-kappaB (NF-kappaB). sodium arsenite 19-34 interleukin 6 Homo sapiens 50-54 14523996-1 2003 In recent studies, sodium arsenite (SA) inhibited IL-6 production in cultured intestinal epithelial cells, at least in part by downregulating the activity of nuclear factor-kappaB (NF-kappaB). sodium arsenite 36-38 interleukin 6 Homo sapiens 50-54 14523996-8 2003 The present results are consistent with the concept that SA inhibits IL-6 production in stimulated enterocytes by downregulating the transcriptional activity of several, but not all, IL-6-related transcription factors. sodium arsenite 57-59 interleukin 6 Homo sapiens 69-73 14523996-8 2003 The present results are consistent with the concept that SA inhibits IL-6 production in stimulated enterocytes by downregulating the transcriptional activity of several, but not all, IL-6-related transcription factors. sodium arsenite 57-59 interleukin 6 Homo sapiens 183-187 21302967-0 2011 Blockade of IL-6 secretion pathway by the sesquiterpenoid atractylenolide III. (+)-Atractylenolide 58-73 interleukin 6 Homo sapiens 12-16 21302967-7 2011 These results provide new insights that atractylenolide III (1) may control immunological reactions by regulating the cellular functions of IL-6 in mast cells. (+)-Atractylenolide 40-55 interleukin 6 Homo sapiens 140-144 14595591-6 2003 In addition, peyote extract induced up to 1.85-, 2.29- and 1.89-fold increases in mRNA signal of IL-1, IL-6 and IL-8 by human leukocytes. Mescaline 13-19 interleukin 6 Homo sapiens 103-107 21215621-0 2011 Design, synthesis and biological evaluation of new thalidomide analogues as TNF-alpha and IL-6 production inhibitors. Thalidomide 51-62 interleukin 6 Homo sapiens 90-94 14586407-3 2003 We further demonstrate that IL-6 protects an esophageal carcinoma cell line CE48T/VGH from apoptosis induced by staurosporine. Staurosporine 112-125 interleukin 6 Homo sapiens 28-32 12971733-2 2003 This study shows the effect of glutamine (Gln) supplementation on the production of tumor necrosis factor alpha, interleukin-10 (IL-10), and interleukin-6 (IL-6). Glutamine 31-40 interleukin 6 Homo sapiens 141-154 14531913-0 2003 Plasma levels of tumour necrosis factor alpha and interleukin-6 predict progression-free survival following thalidomide therapy in patients with previously untreated multiple myeloma. Thalidomide 108-119 interleukin 6 Homo sapiens 50-63 12971733-2 2003 This study shows the effect of glutamine (Gln) supplementation on the production of tumor necrosis factor alpha, interleukin-10 (IL-10), and interleukin-6 (IL-6). Glutamine 31-40 interleukin 6 Homo sapiens 156-160 21215621-1 2011 Several thalidomide analogues were synthesized and compared to thalidomide and its more active analogue, lenalidomide, for their ability to inhibit the production of the pro-inflammatory cytokine tumour necrosis factor (TNF)-alpha and interleukin (IL)-6 by LPS-activated peripheral blood mononuclear cells (PBMCs). Thalidomide 8-19 interleukin 6 Homo sapiens 235-253 12971733-2 2003 This study shows the effect of glutamine (Gln) supplementation on the production of tumor necrosis factor alpha, interleukin-10 (IL-10), and interleukin-6 (IL-6). Glutamine 42-45 interleukin 6 Homo sapiens 141-154 12880609-8 2003 IL-8 and IL-6 production from stimulated biopsies significantly decreased with increasing glutamine concentration from 0.5 to 10mM, (2543 [828-3634] to 1499 [282-2617] for IL-8, 62 [22-117] to 24 [12-99] for IL-6, both P<0.05), whereas IL-10 production was increased (0.7 [0.2-1.6] to 1.2 [2.6-0.5],P<0.05). Glutamine 90-99 interleukin 6 Homo sapiens 9-13 12880609-8 2003 IL-8 and IL-6 production from stimulated biopsies significantly decreased with increasing glutamine concentration from 0.5 to 10mM, (2543 [828-3634] to 1499 [282-2617] for IL-8, 62 [22-117] to 24 [12-99] for IL-6, both P<0.05), whereas IL-10 production was increased (0.7 [0.2-1.6] to 1.2 [2.6-0.5],P<0.05). Glutamine 90-99 interleukin 6 Homo sapiens 208-212 12971733-2 2003 This study shows the effect of glutamine (Gln) supplementation on the production of tumor necrosis factor alpha, interleukin-10 (IL-10), and interleukin-6 (IL-6). Glutamine 42-45 interleukin 6 Homo sapiens 156-160 21215621-1 2011 Several thalidomide analogues were synthesized and compared to thalidomide and its more active analogue, lenalidomide, for their ability to inhibit the production of the pro-inflammatory cytokine tumour necrosis factor (TNF)-alpha and interleukin (IL)-6 by LPS-activated peripheral blood mononuclear cells (PBMCs). Thalidomide 63-74 interleukin 6 Homo sapiens 235-253 12880609-11 2003 CONCLUSIONS: Glutamine was shown in human intestinal mucosa to reduce the production of the pro-inflammatory cytokines IL-6 and IL-8, and enhance the production of the anti-inflammatory cytokine, IL-10. Glutamine 13-22 interleukin 6 Homo sapiens 119-123 21112956-8 2011 CS subjects had significantly higher E-selectin (P = 0.046), IL-6 (P = 0.040), and hs-CRP (P = 0.001) compared with controls. Cesium 0-2 interleukin 6 Homo sapiens 61-65 12891120-7 2003 RESULTS: PGE(2) or 11-deoxy-PGE(1) (EP 2/3/4 agonist) reversed partially the indomethacin suppression of IL-6 secretion from explant cultures, whereas butaprost (EP2 receptor agonist) and sulprostone (EP 1/3 receptor agonist) had no effect. 11-deoxy-pge 19-31 interleukin 6 Homo sapiens 105-109 12611772-0 2003 Glutamine supplementation further enhances exercise-induced plasma IL-6. Glutamine 0-9 interleukin 6 Homo sapiens 67-71 12901869-6 2003 Two NF-kappaB inhibitors, pyrrolidine dithiocarbamanate (PDTC) and SN50, or antisense oligodeoxynucleotides for NF-kappaB p65 and p50 suppressed IL-6 mRNA expressions induced by continuous stretch. Oligodeoxyribonucleotides 86-107 interleukin 6 Homo sapiens 145-149 20739465-10 2011 Hypertonicity-induced increases in IL-6 and IL-8 releases were suppressed by exposure to capsazepine, AG 1478, ERK inhibitor PD 98059, p38 inhibitor SB 203580, or NF-kappaB inhibitor PDTC. RTKI cpd 102-109 interleukin 6 Homo sapiens 35-39 12915334-12 2003 In these experiments EPA was the omega-3 fatty acid responsible for improvement, with distinct effects on inhibition of cytokines formation (IL-1 to IL-6, IL-8, TFN-alpha, GM-CSF), decreased induction of proinflammatory adhesion molecules (selectines, intercellular adhesions molecule-1 (ICAM-1)), and degrading enzymes (e.g. phospholipase A2, cyclooxygenase-2, inducible NO-synthetase). Fatty Acids, Omega-3 33-51 interleukin 6 Homo sapiens 149-153 12953163-5 2003 The inhibitory effect on IL-6 mRNA was prevented by the intermediates of the cholesterol synthesis pathway, mevalonate and geranyl-geranyl-phyrophosphate (GGPP) but not by farnesyl-pyrophosphate. geranyl-geranyl-phyrophosphate 123-153 interleukin 6 Homo sapiens 25-29 12953163-5 2003 The inhibitory effect on IL-6 mRNA was prevented by the intermediates of the cholesterol synthesis pathway, mevalonate and geranyl-geranyl-phyrophosphate (GGPP) but not by farnesyl-pyrophosphate. geranylgeranyl pyrophosphate 155-159 interleukin 6 Homo sapiens 25-29 12953163-6 2003 This suggests the involvement of geranylgeranyl-modified intermediates in the effect of cerivastatin on IL-6. geranylgeranyl 33-47 interleukin 6 Homo sapiens 104-108 12611772-3 2003 During exercise, plasma levels of glutamine decline, and this may affect the concentration of plasma IL-6 via a decrease in IL-6 synthesis and release from muscle. Glutamine 34-43 interleukin 6 Homo sapiens 101-105 12611772-3 2003 During exercise, plasma levels of glutamine decline, and this may affect the concentration of plasma IL-6 via a decrease in IL-6 synthesis and release from muscle. Glutamine 34-43 interleukin 6 Homo sapiens 124-128 12611772-4 2003 We hypothesized that glutamine supplementation would attenuate the exercise-induced decrease in plasma glutamine concentration and, thus, further enhance levels of plasma IL-6. Glutamine 21-30 interleukin 6 Homo sapiens 171-175 12611772-7 2003 Exercise induced an 11-fold increase in plasma IL-6, which was further enhanced by glutamine (18-fold) and glutamine-rich protein (14-fold) supplementation, administered at doses that attenuated the exercise-induced decrease in plasma glutamine concentration. Glutamine 83-92 interleukin 6 Homo sapiens 47-51 12611772-7 2003 Exercise induced an 11-fold increase in plasma IL-6, which was further enhanced by glutamine (18-fold) and glutamine-rich protein (14-fold) supplementation, administered at doses that attenuated the exercise-induced decrease in plasma glutamine concentration. Glutamine 107-116 interleukin 6 Homo sapiens 47-51 12732938-2 2003 We previously reported that the proinflammatory cytokine IL-6 increased the expression of sPLA(2) (a hydrolyzer of phosphatidylcholine) and decreased membrane integrity in an intestinal epithelial cell culture model. Phosphatidylcholines 115-134 interleukin 6 Homo sapiens 57-61 12732938-8 2003 Total intracellular PL contents were also unchanged; however, IL-6 led to significant changes in PL composition including an increase in phosphatidylethanolamine (PE) and sphingomyelin (SM) and a decrease in phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) ( p<0.05). Phosphatidylcholines 208-227 interleukin 6 Homo sapiens 62-66 12732938-8 2003 Total intracellular PL contents were also unchanged; however, IL-6 led to significant changes in PL composition including an increase in phosphatidylethanolamine (PE) and sphingomyelin (SM) and a decrease in phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) ( p<0.05). Phosphatidylcholines 229-231 interleukin 6 Homo sapiens 62-66 12891120-10 2003 In contrast, PGE(2) or 11-deoxy-PGE(1) stimulated secretion of IL-6 from aortic macrophages. 11-deoxy-pge 23-35 interleukin 6 Homo sapiens 63-67 12832326-0 2003 Elevated blood interleukin-6 levels in hyperketonemic type 1 diabetic patients and secretion by acetoacetate-treated cultured U937 monocytes. acetoacetic acid 96-108 interleukin 6 Homo sapiens 15-28 21396307-9 2011 A significantly lower serum interleukin-6 level was found in comparing glutamine-enriched with standard TPN (P = 0.01), but not in interleukin-10 (P = 0.374) and tumor necrosis factor-alpha levels (P = 0.653). Glutamine 71-80 interleukin 6 Homo sapiens 28-41 12832326-8 2003 N-acetylcysteine (NAC) prevented the IL-6 secretion in acetoacetate-treated U937 monocytes. acetoacetic acid 55-67 interleukin 6 Homo sapiens 37-41 12792728-9 2003 In order to investigate the direct relationship between butyrate and IL-6, n-sodium butyrate (n-BT) was added to the NPC cells in an in vitro study, and marked increase of IL-6 expression was detected in n-BT-treated cells. n-sodium butyrate 75-92 interleukin 6 Homo sapiens 172-176 12595539-6 2003 IL-6 increased phosphorylation of STAT3 (at Tyr(705)) and ERK1/2 (at Tyr(204)) within 5 min that peaked at 15-30 min and returned to basal levels at 2 h. Phosphorylation of STAT3 was blocked by genistein, a protein tyrosine kinase inhibitor, and AG490, a JAK2 inhibitor, but not PD98059, an ERK1/2 kinase inhibitor. Genistein 194-203 interleukin 6 Homo sapiens 0-4 12761896-7 2003 Genistein, but not raloxifene, also mimicked E(2) action in the hFOB/ERbeta6 cells increasing PR gene expression and inhibiting IL-6 production. Genistein 0-9 interleukin 6 Homo sapiens 128-132 22129171-6 2011 Treatment with dipyridamole augmented the LPS-induced increase in the antiinflammatory cytokine interleukin (IL)-10 with 274%, and resulted in a more rapid decrease in proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and IL-6 levels directly after their peak level (P < 0.05 and < 0.01, respectively). Dipyridamole 15-27 interleukin 6 Homo sapiens 238-242 12748339-5 2003 RESULTS: Exposure of HPMCs to 1.5% Dianeal reduced cell proliferation, total cellular protein synthesis, IL-6 secretion and cell attachment, but prolonged the cell doubling time on recovery, and increased LDH release (P<0.001, P<0.001, P<0.0001, P<0.0001, P<0.001 and P<0.001, respectively). hpmcs 21-26 interleukin 6 Homo sapiens 105-109 12505790-3 2003 Treatment with the p38 inhibitor SB-203580, the MEK1 and MEK2 inhibitor U-0126, or the translational inhibitor cycloheximide inhibited the induction of C/EBP beta and IL-6 by IFN-gamma, whereas the MEK1 inhibitor PD-98059 or the tyrosine kinase inhibitor genistein had no effect. Genistein 255-264 interleukin 6 Homo sapiens 167-171 12716789-6 2003 Saturated-to-omega-3 and saturated-to-omega-6 FA ratios were significantly and positively associated with C-reactive protein (P < 0.0001) and IL-6 (P < 0.001), respectively. Fatty Acids, Omega-3 13-20 interleukin 6 Homo sapiens 145-149 12716789-13 2003 In overweight men, the ratio of saturated to omega-3 FAs (P = 0.01), but not age, sex, BMI, WHR, or smoking status, independently contributed to 17% of IL-6 variance. Fatty Acids, Omega-3 45-56 interleukin 6 Homo sapiens 152-156 12771946-7 2003 The Mcl-1 HMCLs have a marked reduced apoptosis upon IL-6 starvation compared to HMCLs transduced with control GFP retrovirus and may grow without adding IL-6. hmcls 10-15 interleukin 6 Homo sapiens 53-57 22252762-9 2011 Of the two isomeric compounds, UA showed a higher cytotoxic activity against HSF cells than did OA. ursolic acid 31-33 interleukin 6 Homo sapiens 77-80 12753408-0 2003 Regulation of 1-alpha, 25-dihydroxyvitamin D3 on interleukin-6 and interleukin-8 induced by sulfur mustard (HD) on human skin cells. Mustard Gas 92-106 interleukin 6 Homo sapiens 49-62 12918952-4 2003 The second multicenter study enrolling 88 patients demonstrated that in the survivors, the plasma level of mediators such as TNF-alpha, IL-6, IL-10 and plasminogen activator inhibitor-1 (PAI-1) was significantly decreased following treatment with PMX. (+)-xylariamide A 247-250 interleukin 6 Homo sapiens 136-140 20832949-12 2011 Previous studies in experimental models of cirrhosis and cirrhotic patients have demonstrated that long-term administration of oral antibiotics such as trimethoprim-sulfamethoxazole, norfloxacin, and rifaximin can reduce bacterial translocation and circulating levels of endotoxin, TNF-alpha, IL-6, and NO. Rifaximin 200-209 interleukin 6 Homo sapiens 293-297 12644816-2 2003 Thalidomide blocks the activity of angiogenic agents including bFGF, VEGF and IL-6. Thalidomide 0-11 interleukin 6 Homo sapiens 78-82 12938820-18 2003 Upon short exposure to a single GDP, MCs react with enhanced cytotoxic damage and a proinflammatory response, evidenced by increased VCAM-1 expression and elevated production of IL-6 and IL-8. Guanosine Diphosphate 32-35 interleukin 6 Homo sapiens 178-182 21633494-7 2011 We show that STBM can bind to monocytes and B cells and induce cytokine release (TNFalpha, MIP-1alpha, IL-1alpha, IL-1beta, IL-6, IL-8). stbm 13-17 interleukin 6 Homo sapiens 124-128 21633494-10 2011 We also observed that PBMC from third trimester normal pregnant women produce more TNFalpha and IL-6 in response to STBM than PBMC from non-pregnant women, confirming that maternal immune cells are primed by pregnancy, possibly through their interaction with STBM. stbm 116-120 interleukin 6 Homo sapiens 96-100 12586608-4 2003 CS and CT strongly inhibited the production of proinflammatory cytokines (IL-1alpha, IL-1beta, IL-6, IL-8, and TNF-alpha) from LPS-stimulated human monocytes. Cesium 0-2 interleukin 6 Homo sapiens 95-99 12556010-0 2003 Effects by 8-bromo-cyclicAMP on basal and organic dust-induced release of interleukin-6 and interleukin-8 in A549 human airway epithelial cells. 8-Bromo Cyclic Adenosine Monophosphate 11-28 interleukin 6 Homo sapiens 74-87 12556010-4 2003 We therefore investigated whether 8-Bromo-cAMP, a cell membrane-permeable cAMP analogue, would influence release of the cytokines interleukin-6 (IL-6) and IL-8 in a human airway epithelial cell line, A549, exposed to a suspension of the organic dust, and to a supernatant prepared by centrifugation (at low g-force) of a suspension of dust. 8-Bromo Cyclic Adenosine Monophosphate 34-46 interleukin 6 Homo sapiens 130-143 12556010-4 2003 We therefore investigated whether 8-Bromo-cAMP, a cell membrane-permeable cAMP analogue, would influence release of the cytokines interleukin-6 (IL-6) and IL-8 in a human airway epithelial cell line, A549, exposed to a suspension of the organic dust, and to a supernatant prepared by centrifugation (at low g-force) of a suspension of dust. 8-Bromo Cyclic Adenosine Monophosphate 34-46 interleukin 6 Homo sapiens 145-149 12629150-5 2003 The Fas agonistic antibody CH-11 dose-dependently stimulated the expression of IL-6 and IL-8 in glioma cells. 4-dimethylamino-3',4'-dimethoxychalcone 27-32 interleukin 6 Homo sapiens 79-83 12631257-0 2003 Pamidronate is superior to ibandronate in decreasing bone resorption, interleukin-6 and beta 2-microglobulin in multiple myeloma. Pamidronate 0-11 interleukin 6 Homo sapiens 70-83 12556010-8 2003 8-Bromo-cAMP (1 mM) doubled basal IL-6 release and IL-6 release induced by a dust supernatant (P<0.01), and increased IL-6 release induced by a dust suspension by 19% (P<0.05). 8-Bromo Cyclic Adenosine Monophosphate 0-12 interleukin 6 Homo sapiens 34-38 25215012-10 2011 The levels of serum ALT, AST, TBiL and TNF-alpha, IL-6 were lower in the Gln group than in the non-Gln group (P<0.01). Glutamine 73-76 interleukin 6 Homo sapiens 50-54 12556010-8 2003 8-Bromo-cAMP (1 mM) doubled basal IL-6 release and IL-6 release induced by a dust supernatant (P<0.01), and increased IL-6 release induced by a dust suspension by 19% (P<0.05). 8-Bromo Cyclic Adenosine Monophosphate 0-12 interleukin 6 Homo sapiens 51-55 12556010-8 2003 8-Bromo-cAMP (1 mM) doubled basal IL-6 release and IL-6 release induced by a dust supernatant (P<0.01), and increased IL-6 release induced by a dust suspension by 19% (P<0.05). 8-Bromo Cyclic Adenosine Monophosphate 0-12 interleukin 6 Homo sapiens 51-55 12556010-10 2003 In summary, expression of the cytokines IL-6 and IL-8 is differentially regulated by 8-Bromo-cAMP, both with regard to basal and dust-induced release. 8-Bromo Cyclic Adenosine Monophosphate 85-97 interleukin 6 Homo sapiens 40-44 12556067-6 2002 RESULTS: After pre-exposure to Lac-PDF, PMphi generated 242 +/- 279 pg TNFalpha/10(6) cells and 157 +/- 105 pg IL-6/10(6) cells. lac-pdf 31-38 interleukin 6 Homo sapiens 111-115 12631257-6 2003 RESULTS: In both groups, the combination of chemotherapy with either pamidronate or ibandronate produced a reduction in bone resorption and tumour burden as measured by NTX, IL-6, paraprotein, CRP, and beta 2-microglobulin from the second month of treatment, having no effect on bone formation. Pamidronate 69-80 interleukin 6 Homo sapiens 174-178 12631257-11 2003 CONCLUSIONS: These results suggest that a monthly dose of 90 mg of pamidronate is more effective than 4 mg of ibandronate in reducing osteoclast activity, bone resorption, IL-6, and possibly tumour burden in MM. Pamidronate 67-78 interleukin 6 Homo sapiens 172-176 12496440-6 2003 Arg-Gly-Asp-Ser peptide and neo-glycoproteins galactose-BSA and mannose-BSA inhibited the Der f-induced IL-6 and TNF-alpha productions and enhanced accessory function of AMs. Mannose 64-71 interleukin 6 Homo sapiens 104-108 12509942-5 2002 RESULTS: The levels of IL-6 and TNF-gamma in HMCL supernatants were dramatically increased when cultured HMCL were stimulated by IL-1beta (10 ng/ml). hmcl 45-49 interleukin 6 Homo sapiens 23-27 21098664-3 2010 Biological relevance is shown by the observation that overexpression of SOCS3 when K140 cannot be methylated blocks the ability of cells to activate STAT3 in response to IL-6. k140 83-87 interleukin 6 Homo sapiens 170-174 12241537-2 2002 We tested the hypothesis that sodium arsenite inhibits IL-6 production in stimulated enterocytes and that this effect of arsenite is caused by down-regulation of NF-kappaB activity. sodium arsenite 30-45 interleukin 6 Homo sapiens 55-59 12214267-0 2002 FR901228, an inhibitor of histone deacetylases, increases the cellular responsiveness to IL-6 type cytokines by enhancing the expression of receptor proteins. romidepsin 0-8 interleukin 6 Homo sapiens 89-93 12214267-6 2002 Depending on the cell type, FR treatment also enhances the responsiveness to OSM and IL-6. romidepsin 28-30 interleukin 6 Homo sapiens 85-89 12241537-8 2002 When cells were transfected with a plasmid expressing the p65 subunit of NF-kappaB, the inhibitory effect of sodium arsenite on NF-kappaB activity and IL-6 production was blunted. sodium arsenite 109-124 interleukin 6 Homo sapiens 151-155 21057728-9 2010 DSPs increased the expression of intercellular adhesion molecule 1 and the release of interleukin-6 in HASMCs, both of which were inhibited by ERK1/2 or NF-kappaB pathway inhibitors. hasmcs 103-109 interleukin 6 Homo sapiens 86-99 12241537-9 2002 These results suggest that sodium arsenite inhibits IL-6 production in enterocytes subjected to an inflammatory stimulus, and that this effect, at least in part, reflects down-regulated NF-kappaB activity. sodium arsenite 27-42 interleukin 6 Homo sapiens 52-56 12607189-8 2002 The antiH-1, emedastine, significantly reduced H-induced production of IL-1, IL-6 and IL-8, while azelastine reduced only IL-1. emedastine 13-23 interleukin 6 Homo sapiens 77-81 12143988-4 2002 We also found that cobalt ion-enriched medium increased the production of interleukin-6 from the osteoblast-like cells. Cobalt 19-25 interleukin 6 Homo sapiens 74-87 12349949-7 2002 Genistein, a tyrosine kinase inhibitor, and H-7, a protein kinase C inhibitor, also inhibited IL-6 secretion but not MIF secretion in both LPS- and H2O2-stimulated fibroblasts. Genistein 0-9 interleukin 6 Homo sapiens 94-98 20599324-5 2010 TB-2-081 displaces the binding of IL-6 to the human recombinant soluble IL-6 receptor with apparent high affinity and inhibits IL-6 mediated cell growth. 20,21-epoxyresibufogenin-3-formate 0-8 interleukin 6 Homo sapiens 34-38 12137803-0 2002 RU486 antagonizes the inhibitory effect of peroxisome proliferator-activated receptor alpha on interleukin-6 production in vascular endothelial cells. Mifepristone 0-5 interleukin 6 Homo sapiens 95-108 12137803-3 2002 In this investigation, we showed that RU486, already proved to be an active anti-glucocorticoid and anti-progesterone agent, blocked the inhibition of tumor necrosis factor (TNF)-alpha-stimulated interleukin-6 (IL-6) production by the PPARalpha activator fenofibrate in human umbilical vein ECs. Mifepristone 38-43 interleukin 6 Homo sapiens 196-209 12137803-3 2002 In this investigation, we showed that RU486, already proved to be an active anti-glucocorticoid and anti-progesterone agent, blocked the inhibition of tumor necrosis factor (TNF)-alpha-stimulated interleukin-6 (IL-6) production by the PPARalpha activator fenofibrate in human umbilical vein ECs. Mifepristone 38-43 interleukin 6 Homo sapiens 211-215 12137803-6 2002 Thus, RU486 has an antagonizing effect on PPARalpha-mediated down-regulation of IL-6 in vascular ECs. Mifepristone 6-11 interleukin 6 Homo sapiens 80-84 12067898-6 2002 Pretreatment with pertussis toxin, GF109203X, and pyrrolidine dithiocarbamate inhibited MCP-1-dependent IL-6 release, suggesting the involvement of G(i) proteins, protein kinase C, and nuclear factor-kappaB (NF-kappaB). pyrrolidine dithiocarbamic acid 50-77 interleukin 6 Homo sapiens 104-108 12039983-6 2002 Pretreatment with pertussis toxin, GF109203X, BAPTA-AM, and pyrrolidine dithiocarbamate inhibited MCP-1-dependent IL-6 and ICAM-1 synthesis, suggesting the involvement of Gi-proteins, protein kinase C, intracellular Ca(2+), and nuclear factor-kappaB (NF-kappaB) in MCP-1 signaling. pyrrolidine dithiocarbamic acid 60-87 interleukin 6 Homo sapiens 114-118 12023527-7 2002 Furthermore, pro-inflammatory cytokine interleukin-6 (IL-6) produced a leftward shift of the concentration-response curve to the BK B(1) receptor agonist, whereas anti-inflammatory cytokines interleukin-4 (IL-4) and tumor growth factor-beta1 (TGF-beta1) produced a rightward shift of the responses to des-Arg(9)-BK in our preparations. des-arg 301-308 interleukin 6 Homo sapiens 39-52 12023527-7 2002 Furthermore, pro-inflammatory cytokine interleukin-6 (IL-6) produced a leftward shift of the concentration-response curve to the BK B(1) receptor agonist, whereas anti-inflammatory cytokines interleukin-4 (IL-4) and tumor growth factor-beta1 (TGF-beta1) produced a rightward shift of the responses to des-Arg(9)-BK in our preparations. des-arg 301-308 interleukin 6 Homo sapiens 54-58 12009364-10 2002 1alpha,25(OH)(2)-vitamin D(3), with or without 17beta-E(2), decreased interleukin-6 levels to 27% and 38% of control group, respectively. 25(oh)(2)-vitamin d 7-26 interleukin 6 Homo sapiens 70-83 20599324-5 2010 TB-2-081 displaces the binding of IL-6 to the human recombinant soluble IL-6 receptor with apparent high affinity and inhibits IL-6 mediated cell growth. 20,21-epoxyresibufogenin-3-formate 0-8 interleukin 6 Homo sapiens 72-76 12515619-0 2002 [Influence of thalidomide on interleukin-6 and its transmission in multiple myeloma patients]. Thalidomide 14-25 interleukin 6 Homo sapiens 29-42 12515619-1 2002 OBJECTIVE: To evaluate the mechanism and influence of thalidomide on interleukin-6 (IL-6), IL-6 receptor (IL-6R) and its transmitting chain in multiple myeloma patients. Thalidomide 54-65 interleukin 6 Homo sapiens 69-82 20698827-5 2010 Interestingly, exposure of DS-HSF to dibutyryl-cAMP, a permanent derivative of cAMP, stimulated ANT, AK and ATPase activities, whereas H89, a specific PKA (protein kinase A) inhibitor, suppressed this cAMPdependent activation, indicating an involvement of the cAMP/PKA-mediated signalling pathway in the ATPase, ANT and AK deficit. campdependent 201-214 interleukin 6 Homo sapiens 30-33 12515619-1 2002 OBJECTIVE: To evaluate the mechanism and influence of thalidomide on interleukin-6 (IL-6), IL-6 receptor (IL-6R) and its transmitting chain in multiple myeloma patients. Thalidomide 54-65 interleukin 6 Homo sapiens 84-88 12515619-3 2002 RESULTS: Serum level of IL-6 in multiple myeloma patients was 564.8 +/- 319.4 ng/L, with a positive rate on the myeloma cells of 33.6% before oral 200 mg/d thalidomide. Thalidomide 156-167 interleukin 6 Homo sapiens 24-28 11877294-3 2002 Furthermore, the IL-6-induced proliferation of CD45+ U266 myeloma cells was significantly suppressed by Lyn-specific antisense oligodeoxynucleotides or a selective src kinase inhibitor. Oligodeoxyribonucleotides 127-148 interleukin 6 Homo sapiens 17-21 12515619-8 2002 CONCLUSION: Reduction of serum level of IL-6 in multiple myeloma patients and decrease in IL-6R expression on the myeloma cells and IL-6R beta mRNA occur on D14 after oral 400 mg/d thalidomide. Thalidomide 181-192 interleukin 6 Homo sapiens 40-44 20851233-0 2010 The effects of mifepristone on the expressions of osteopontin, interleukin-6 and leukemia inhibitory factor in the villi of early pregnant women. Mifepristone 15-27 interleukin 6 Homo sapiens 63-76 12515619-10 2002 The antitumor mechanism of thalidomide may be related to reduction of IL-6 serum level in multiple myeloma patients and decrease in IL-6R expression on the myeloma cells and IL-6R beta mRNA. Thalidomide 27-38 interleukin 6 Homo sapiens 70-74 11942326-4 2002 Here we demonstrate that cisplatin (CDDP) and etoposide (VP-16) induce nuclear translocation of NF-kappaB in prostate cancer cell lines, followed by secretion of IL-6. Etoposide 46-55 interleukin 6 Homo sapiens 162-166 11805217-7 2002 Reversible competitive inhibition of PDE4 (rolipram) exhibited a potent inhibitory effect on IL-6 and a dual, biphasic (excitatory/inhibitory) effect on TNF-alpha secretion. Rolipram 43-51 interleukin 6 Homo sapiens 93-97 12096924-0 2002 Glutamine decreases interleukin-8 and interleukin-6 but not nitric oxide and prostaglandins e(2) production by human gut in-vitro. Glutamine 0-9 interleukin 6 Homo sapiens 38-51 12513842-8 2002 Inhibiting tumor cells secreting level of IL-6 and reducing the expression of IL-6 receptor on myeloma cell surface is one of the mechanisms for thalidomide to remedy multiple myeloma patients Thalidomide 145-156 interleukin 6 Homo sapiens 42-46 20851233-2 2010 This study was performed to determine the effects of mifepristone on OPN, LIF and IL-6 mRNA and protein expressions in the villi in early pregnancy. Mifepristone 53-65 interleukin 6 Homo sapiens 82-86 12513842-8 2002 Inhibiting tumor cells secreting level of IL-6 and reducing the expression of IL-6 receptor on myeloma cell surface is one of the mechanisms for thalidomide to remedy multiple myeloma patients Thalidomide 145-156 interleukin 6 Homo sapiens 78-82 12096924-8 2002 RESULTS: Glutamine decreased IL-8 and IL-6 in-vitro production: 63 [2-173] vs 100 [19-177] and 37 [5-489] vs 100 [33-431], both P<0.05. Glutamine 9-18 interleukin 6 Homo sapiens 38-42 20679445-4 2010 SitC-His induced interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) release in human monocytes and also NF-kappaB activation in TLR2-transfected HEK293 cells, indicating TLR2-specific activation. sitc-his 0-8 interleukin 6 Homo sapiens 17-30 11893605-1 2002 In previous studies, the heat shock response, induced by hyperthermia or sodium arsenite, increased interleukin (IL)-6 production in intestinal mucosa and cultured human enterocytes. sodium arsenite 73-88 interleukin 6 Homo sapiens 100-118 11842936-6 2002 11-deoxy-PGE1, a selective EP2/EP3/EP4 agonist, and butaprost, a selective EP2 agonist, inhibited IL-1beta-induced IL-6 production, although butaprost was less potent than 11-deoxy-PGE1. 11-deoxyprostaglandin E1 0-13 interleukin 6 Homo sapiens 115-119 11777983-7 2002 EMSAs demonstrated that IL-17, IL-1beta, and TNF-alpha induced NF-kappaB activation within 1.5 h after stimulation, and a blockade of NF-kappaB activation by the pyrrolidine derivative of dithiocarbamate and tosyl-phe-chloromethylketone markedly reduced the IL-17-, IL-1beta-, or TNF-alpha-induced IL-6 gene expression. pyrrolidine 162-173 interleukin 6 Homo sapiens 298-302 11777983-7 2002 EMSAs demonstrated that IL-17, IL-1beta, and TNF-alpha induced NF-kappaB activation within 1.5 h after stimulation, and a blockade of NF-kappaB activation by the pyrrolidine derivative of dithiocarbamate and tosyl-phe-chloromethylketone markedly reduced the IL-17-, IL-1beta-, or TNF-alpha-induced IL-6 gene expression. Dithiocarbamate 188-203 interleukin 6 Homo sapiens 298-302 20679445-4 2010 SitC-His induced interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) release in human monocytes and also NF-kappaB activation in TLR2-transfected HEK293 cells, indicating TLR2-specific activation. sitc-his 0-8 interleukin 6 Homo sapiens 32-36 20605877-7 2010 However, this enhanced potency was selective for TLR9-induced B-cell cycling and apoptosis protection while TLR9-induced IL-6, an event that strongly depends on signaling via late endosomes, still required 10 times more Class R oligodeoxynucleotides. Oligodeoxyribonucleotides 228-249 interleukin 6 Homo sapiens 121-125 12653178-12 2002 We have also found that n-3 fatty acids plus CoQ can decrease TNF-alpha and IL-6 in AMI which are pro-inflammatory agents. Fatty Acids, Omega-3 24-39 interleukin 6 Homo sapiens 76-80 11844650-3 2002 RESULTS: Estrogen, statins, and PUFAs enhance nitric oxide synthesis, suppress the production of proinflammatory cytokines such as tumor necrosis factor(alpha), interleukin-1, interleukin-2, and interleukin-6, show antioxidant-like and antiatherosclerotic properties, have neuroprotective actions, and by themselves or their products inhibit tumor cell proliferation and improve osteoporosis. Fatty Acids, Unsaturated 32-37 interleukin 6 Homo sapiens 195-208 12513842-2 2002 The level of interleukin-6 (IL-6) autosecreted by myeloma cells was tested by IL-6-dependent cell line when myeloma cells were treated with thalidomide at 200 microgram/ml, and in the same concentration of thalidomide the expression of IL-6 receptor were tested by flow cytometry. Thalidomide 140-151 interleukin 6 Homo sapiens 13-26 12513842-2 2002 The level of interleukin-6 (IL-6) autosecreted by myeloma cells was tested by IL-6-dependent cell line when myeloma cells were treated with thalidomide at 200 microgram/ml, and in the same concentration of thalidomide the expression of IL-6 receptor were tested by flow cytometry. Thalidomide 140-151 interleukin 6 Homo sapiens 28-32 12513842-2 2002 The level of interleukin-6 (IL-6) autosecreted by myeloma cells was tested by IL-6-dependent cell line when myeloma cells were treated with thalidomide at 200 microgram/ml, and in the same concentration of thalidomide the expression of IL-6 receptor were tested by flow cytometry. Thalidomide 206-217 interleukin 6 Homo sapiens 13-26 12513842-2 2002 The level of interleukin-6 (IL-6) autosecreted by myeloma cells was tested by IL-6-dependent cell line when myeloma cells were treated with thalidomide at 200 microgram/ml, and in the same concentration of thalidomide the expression of IL-6 receptor were tested by flow cytometry. Thalidomide 206-217 interleukin 6 Homo sapiens 28-32 12513842-5 2002 After treatment with thalidomide at 200 microgram/ml, the concentrations of IL-6 secreted by myeloma cells were (148.5 +/- 96.7) microgram/ml, and the levels of IL-6 receptor expressed on the cell surface were 16.7% and 20.2% in untreated and relapsed or refractory patients, respectively, and those were significantly lower than those levels in the cells before exposure to thalidomide. Thalidomide 21-32 interleukin 6 Homo sapiens 76-80 12513842-5 2002 After treatment with thalidomide at 200 microgram/ml, the concentrations of IL-6 secreted by myeloma cells were (148.5 +/- 96.7) microgram/ml, and the levels of IL-6 receptor expressed on the cell surface were 16.7% and 20.2% in untreated and relapsed or refractory patients, respectively, and those were significantly lower than those levels in the cells before exposure to thalidomide. Thalidomide 21-32 interleukin 6 Homo sapiens 161-165 12513842-5 2002 After treatment with thalidomide at 200 microgram/ml, the concentrations of IL-6 secreted by myeloma cells were (148.5 +/- 96.7) microgram/ml, and the levels of IL-6 receptor expressed on the cell surface were 16.7% and 20.2% in untreated and relapsed or refractory patients, respectively, and those were significantly lower than those levels in the cells before exposure to thalidomide. Thalidomide 375-386 interleukin 6 Homo sapiens 161-165 12614487-8 2002 In patients with overt diabetes or insulin resistance, TZD treatment can lower blood levels of C-reactive protein and interleukin-6, markers of inflammation and cardiovascular risk. 2,4-thiazolidinedione 55-58 interleukin 6 Homo sapiens 118-131 11792072-7 2002 We conclude that human AM exposed to PM10 produce mediators, particularly IL-6 and GM-CSF that promote the differentiation of bone marrow myeloid cells and we speculate that these cytokines are involved in the release of granulocytes from the bone marrow associated with exposure to air pollution particulates. pm10 37-41 interleukin 6 Homo sapiens 74-78 20877565-10 2010 EGCG also inhibited IL6 secretion and IFN- beta mRNA synthesis in BEAS-2B cells, which harbors intact endogenous RIG-I signaling pathway. epigallocatechin gallate 0-4 interleukin 6 Homo sapiens 20-23 11957802-6 2002 In the group of patients received TPN (with glutamine) there was a significantly increased but in comparison with group of patients without TPN, significantly lower level of IL-6 on days 1 and 7 (103.4 and 34.7 pg/ml respectively, p = 0.01). Glutamine 44-53 interleukin 6 Homo sapiens 174-178 11885806-2 2002 Our study was designed to determine whether heat shock and drugs like cisplatin, etoposide and quercetin have an effect on the expression of heat shock protein 27 in tumour cells such as: HeLa (cervical cancer), Hep-2 (larynx cancer), A549 (lung cancer) and also in normal human skin fibroblasts (HSF) cultured in two-dimensional (2D) and three-dimensional (3D) conditions. Etoposide 81-90 interleukin 6 Homo sapiens 297-300 11916128-7 2002 The histamine-induced up-regulation of IL-6 and IL-8 production, however, was completely abrogated by a combination of pyrilamine and cimetidine. Pyrilamine 119-129 interleukin 6 Homo sapiens 39-43 20712901-6 2010 Furthermore, FLLL32 selectively inhibited the induction of STAT3 phosphorylation by Interleukin-6 but not STAT1 phosphorylation by IFN-gamma. FLLL 32 13-19 interleukin 6 Homo sapiens 84-97 11710628-6 2001 RESULTS: Although docetaxel (5 mg/kg) alone did not decrease either tumor growth or serum IL-6 levels, docetaxel (5 mg/kg) plus 5"-dFUrd or tegafur enhanced tumor growth inhibition and decreased serum IL-6 levels more than 5"-dFUrd or tegafur alone. Tegafur 140-147 interleukin 6 Homo sapiens 201-205 11713366-8 2001 RESULTS: IL-6 and Dex synergistically induced HIV expression in U1 cells, and this effect was blocked by RU 486. Mifepristone 105-111 interleukin 6 Homo sapiens 9-13 11898070-7 2002 RESULTS: Incubation of a human bone marrow cell culture with titanium-aluminium-vanadium particles led to a maximum release of interleukin-6, interleukin-1beta, and TNF-alpha at high particle concentration (10(9) particles per ml medium). titanium-aluminium-vanadium 61-88 interleukin 6 Homo sapiens 127-140 11739453-5 2001 Plasma IL-6 levels increased during a 3-h infusion of isoproterenol (P = 0.01) and fell 2 h post infusion (P = 0.05). Isoproterenol 54-67 interleukin 6 Homo sapiens 7-11 11739453-9 2001 IN VITRO STUDIES: In human peripheral blood cells, lipopolysaccharide treatment enhanced secretion of IL-6 (vs. controls; P < 0.001), whereas isoproterenol inhibited IL-6 secretion (P = 0.012) and norepinephrine had no significant effect. Isoproterenol 145-158 interleukin 6 Homo sapiens 169-173 11675420-8 2001 Exposure to GDP resulted in a significant reduction in mesothelial IL-6 and fibronectin release. Guanosine Diphosphate 12-15 interleukin 6 Homo sapiens 67-71 11593406-6 2001 Inhibition of Akt activation by the PI3-K inhibitor LY294002 partially blocked IL-6 triggered MEK/MAPK activation and proliferation in MM.1S cells, suggesting cross-talk between PI3-K and MEK signaling. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 52-60 interleukin 6 Homo sapiens 79-83 20637104-12 2010 Finally, using array analysis, we found that both live and PFA-fixed G2B-10A cells induced R2-T1AS cells to secrete specific cytokines (IL-6 and GM-CSF), suggesting that cell-cell contact activates R2-T1AS cells. paraform 59-62 interleukin 6 Homo sapiens 136-140 11593406-8 2001 LY294002 completely abrogates this signaling cascade, further confirming the importance of PI3-K/Akt signaling in conferring the protective effect of IL-6 against Dex-induced apoptosis. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 interleukin 6 Homo sapiens 150-154 11593406-9 2001 Finally, we show that IL-6 triggered PI3-K/Akt signaling in MM.1S cells inactivates forkhead transcriptional factor (FKHR), with related G1/S phase transition, whereas LY294002 blocks this signaling, resulting in upregulation of p27(KIP1) and G1 growth arrest. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 168-176 interleukin 6 Homo sapiens 22-26 11592764-1 2001 Thalidomide is reported to suppress levels of several cytokines, angiogenic and growth factors including TNF-alpha, basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6). Thalidomide 0-11 interleukin 6 Homo sapiens 201-214 11592764-1 2001 Thalidomide is reported to suppress levels of several cytokines, angiogenic and growth factors including TNF-alpha, basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6). Thalidomide 0-11 interleukin 6 Homo sapiens 216-220 20228251-1 2010 Oxidative stress induced by inhibition of glutathione (GSH) biosynthesis with D,L-buthionine-S,R-sulfoximine (BSO) causes human microglia, human astrocytes, THP-1 cells, and U373 cells to secrete materials toxic to human neuroblastoma SH-SY5Y cells and stimulates them to release TNF-alpha, IL-6, and nitrite ions. s,r-sulfoximine 93-108 interleukin 6 Homo sapiens 291-295 11766126-0 2001 The role of interleukin-6 (IL-6) in human sulfur mustard (HD) toxicology. Mustard Gas 42-56 interleukin 6 Homo sapiens 27-31 11556519-8 2001 RESULTS: We have demonstrated that aceclofenac, 4"-hydroxyaceclofenac and diclofenac significantly decreased interleukin-6 production at concentrations ranged among 1 to 30 microM and fully blocked prostaglandin E2 synthesis by IL-1beta- or LPS-stimulated human chondrocytes. aceclofenac 35-46 interleukin 6 Homo sapiens 109-122 11556519-8 2001 RESULTS: We have demonstrated that aceclofenac, 4"-hydroxyaceclofenac and diclofenac significantly decreased interleukin-6 production at concentrations ranged among 1 to 30 microM and fully blocked prostaglandin E2 synthesis by IL-1beta- or LPS-stimulated human chondrocytes. 4'-hydroxyaceclofenac 48-69 interleukin 6 Homo sapiens 109-122 11513771-8 2001 CONCLUSIONS: Our data show that LH is associated with a higher production of inflammatory cytokines (IFN-gamma and IL-6) compared with BH, likely induced by the presence of the polypropylene prostheses. Luteinizing Hormone 32-34 interleukin 6 Homo sapiens 115-119 11513771-8 2001 CONCLUSIONS: Our data show that LH is associated with a higher production of inflammatory cytokines (IFN-gamma and IL-6) compared with BH, likely induced by the presence of the polypropylene prostheses. Polypropylenes 177-190 interleukin 6 Homo sapiens 115-119 11424089-10 2001 Treatment with PI3K inhibitor, wortmannin or LY294002, abrogated not only PKCdelta translocation but the subsequent transcriptional activation of HSF and HIF-1 by hypoxia. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 45-53 interleukin 6 Homo sapiens 146-149 11369659-9 2001 Actinomycin D and genistein blocked IL-6 production, whereas staurosporine did not, suggesting that CD44-dependent IL-6 production requires gene transcription and tyrosine kinase activity. Genistein 18-27 interleukin 6 Homo sapiens 36-40 11369659-9 2001 Actinomycin D and genistein blocked IL-6 production, whereas staurosporine did not, suggesting that CD44-dependent IL-6 production requires gene transcription and tyrosine kinase activity. Genistein 18-27 interleukin 6 Homo sapiens 115-119 11344240-7 2001 On the other hand, 24-h exposure to 10 nmol/L IL-6 increased basal glycerol release by 42 +/- 12% (P < 0.01) and isoproterenol-induced glycerol release by 21 +/- 6% (P < 0.05). Isoproterenol 116-129 interleukin 6 Homo sapiens 46-50 20378717-4 2010 We found that beta-escin, a pentacyclic triterpenoid, inhibited both constitutive and interleukin-6-inducible STAT3 activation in a dose- and time-dependent manner in HCC cells. triterpenoid TP-222 40-52 interleukin 6 Homo sapiens 86-99 11344240-9 2001 IL-6 secretion was acutely and chronically stimulated by 1 micromol/L isoproterenol (peak of 6.2-fold after 3 h; P < 0.001) and only moderately suppressed by 100 nmol/L cortisol (-36 +/- 10%; P < 0.001). Isoproterenol 70-83 interleukin 6 Homo sapiens 0-4 11497296-5 2001 RESULTS: Phenytoin and carbamazepine, which inactivate voltage-gated sodium channels, inhibited the secretion of PSA by LNCaP and IL-6 by DU-145 and PC-3 cell lines. Carbamazepine 23-36 interleukin 6 Homo sapiens 130-134 20388727-6 2010 Salbutamol (>or= 0.1 microM) significantly inhibited the release of TNF-alpha, but also significantly enhanced that of IL-6. Albuterol 0-10 interleukin 6 Homo sapiens 122-126 11161457-6 2001 RESULTS: glutamine given in vivo and in vitro significantly decreased IL-6 [1.4 (0.8-8.5) vs 8.9 (1.0-43.9)] and IL-8 production [5.8 (0-51.4) vs. 53.0 (2.5-114.6), pg/mg wet tissue], median (range), both P< or =0.01, in comparison to no glutamine experiments. Glutamine 9-18 interleukin 6 Homo sapiens 70-74 20576164-8 2010 In peripheral blood mononuclear cells (PBMCs), FLLL32 inhibited IL-6-induced pSTAT3 but did not reduce signaling in response to immunostimulatory cytokines (IFN-gamma, IL 2). FLLL 32 47-53 interleukin 6 Homo sapiens 64-68 11270500-8 2001 Several studies have shown macrolides to inhibit interleukin gene expression for IL-6 and IL-8 and also to inhibit the expression of intercellular adhesion molecule essential for the recruitment of inflammatory cells. Macrolides 27-37 interleukin 6 Homo sapiens 81-85 11277180-10 2001 Higher IL-6 and IL-8 levels were directly associated with lower phosphorus levels. Phosphorus 64-74 interleukin 6 Homo sapiens 7-11 20451499-4 2010 Thrombin activated Akt, PKC and MAPK in HAoSMC, and thrombin-mediated expression of IL-6 and CXCL8 was significantly inhibited by LY294002, AKT IV, RO318220, and GF109203X as well as by diphenyleneiodium at the messenger RNA and the protein levels. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 130-138 interleukin 6 Homo sapiens 84-88 11339625-9 2001 When amorphous silica and quartz were compared, the amorphous silica was most potent to induce IL - 6 regardless of how exposure was expressed, whereas the smallest size fraction of quartz was the most potent inducer of IL-8. Silicon Dioxide 62-68 interleukin 6 Homo sapiens 95-101 11007619-4 2000 Exposure to titanium-aluminum-vanadium particles significantly changed the release of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 (IL-1), whereas there was no significant effect on the release of prostaglandin E(2) (PGE(2)). titanium-aluminum-vanadium 12-38 interleukin 6 Homo sapiens 127-140 11007619-4 2000 Exposure to titanium-aluminum-vanadium particles significantly changed the release of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 (IL-1), whereas there was no significant effect on the release of prostaglandin E(2) (PGE(2)). titanium-aluminum-vanadium 12-38 interleukin 6 Homo sapiens 142-146 11134660-5 2000 Indirubin exerted its inhibitory effects not only on interferon-gamma production by human myelomonocytic HBL-38 cells but also on interferon-gamma and interleukin-6 production by murine splenocytes with no influence on the proliferation of either cells. indirubin 0-9 interleukin 6 Homo sapiens 151-164 20100571-4 2010 We have observed that treatment of human 1321N1 astrocytes with the beta-adrenergic agonist isoproterenol synergistically enhanced TNF-alpha-induced expression of the cytokine IL-6. Isoproterenol 92-105 interleukin 6 Homo sapiens 176-180 11205205-5 2000 RESULTS: After LNT treatment, CD4+ IFN-gamma+ T-cell percentages increased significantly (p < 0.05), whereas CD4+ IL-4+ T-cell and CD4+ IL-6+ T-cell percentages decreased significantly (p < 0.02). Lentinan 15-18 interleukin 6 Homo sapiens 139-143 11024008-5 2000 Pretreatment with pertussis toxin or pyrrolidine dithiocarbamate inhibited complement-dependent IL-6 mRNA expression and IL-6 release, suggesting the involvement of Gi-proteins and nuclear factor-kB (NF-kB). pyrrolidine dithiocarbamic acid 37-64 interleukin 6 Homo sapiens 96-100 11024008-5 2000 Pretreatment with pertussis toxin or pyrrolidine dithiocarbamate inhibited complement-dependent IL-6 mRNA expression and IL-6 release, suggesting the involvement of Gi-proteins and nuclear factor-kB (NF-kB). pyrrolidine dithiocarbamic acid 37-64 interleukin 6 Homo sapiens 121-125 11080198-6 2000 However, simultaneous administration of NPY at 10(-9) M: and the beta-adrenergic agonist isoproterenol at 10(-6) M: or NE at 10(-6) M: significantly increased IL-6 secretion (p < 0.005). Isoproterenol 89-102 interleukin 6 Homo sapiens 159-163 11106000-5 2000 Among the compounds, sophoricoside exhibited the highest inhibitory effects on IL-5, IL-3 and IL-6 bioactivities with IC50 values of 1.9 microM, 6.9 microM and 6.0 microM, respectively and orobol did show on GM-CSF bioactivity with an IC50 value of 18.0 microM. sophoricoside 21-34 interleukin 6 Homo sapiens 94-98 20100571-7 2010 Simultaneous induction with isoproterenol and TNF-alpha was moreover associated with combined recruitment of CREB and p65 to the native IL-6 promoter. Isoproterenol 28-41 interleukin 6 Homo sapiens 136-140 11037761-7 2000 The amounts of IL-6 were induced 25- to 30-fold by PdCl2 under physiological conditions, and IL-8 levels were also slightly enhanced. palladium chloride 51-56 interleukin 6 Homo sapiens 15-19 11114962-6 2000 CONCLUSIONS: Diabetic women with ASB have lower urinary IL-6 concentrations than nondiabetic bacteriuric controls. asb 33-36 interleukin 6 Homo sapiens 56-60 20487003-6 2010 The presence of EGCG and ECG significantly reduced, in a concentration-dependent manner, the expression of IL-6 and IL-8 in dental pulp cells exposed to LPS or PG. epigallocatechin gallate 16-20 interleukin 6 Homo sapiens 107-111 11094787-8 2000 The increase in IL-6 levels observed in the clinically responsive, and to a lesser extent, tolerant, states following zinc oxide inhalation is consistent with the dual role of IL-6 as a pyrogen and anti-inflammatory agent. Zinc Oxide 118-128 interleukin 6 Homo sapiens 16-20 11094787-8 2000 The increase in IL-6 levels observed in the clinically responsive, and to a lesser extent, tolerant, states following zinc oxide inhalation is consistent with the dual role of IL-6 as a pyrogen and anti-inflammatory agent. Zinc Oxide 118-128 interleukin 6 Homo sapiens 176-180 11000053-2 2000 Analysis of cirrhotic livers suggests that IL-6 may stimulate the activity of pyridoxal phosphatase in hepatocytes, thereby diminishing pyridoxal phosphate levels, compromising cystathionine beta-synthase activity, and raising plasma homocyst(e)ine. Pyridoxal Phosphate 136-155 interleukin 6 Homo sapiens 43-47 10920220-6 2000 The protein kinase C inhibitor, H7, and the serine/threonine kinase inhibitor, genistein, abolished the particle-induced increase in IL-6 release at a concentration of 100 microM for each compound. Genistein 79-88 interleukin 6 Homo sapiens 133-137 20215512-7 2010 In addition, we show that FLLL32 can inhibit the induction of STAT3 phosphorylation by IFNalpha and interleukin-6 in breast cancer cells. FLLL 32 26-32 interleukin 6 Homo sapiens 100-113 10915744-5 2000 Four- and 10-fold activation of stress protein was detected by a consensus heat shock factor (HSF) sequence binding probe, with AFB and BP treatments, respectively. Aflatoxin B1 128-131 interleukin 6 Homo sapiens 75-92 10915744-5 2000 Four- and 10-fold activation of stress protein was detected by a consensus heat shock factor (HSF) sequence binding probe, with AFB and BP treatments, respectively. Aflatoxin B1 128-131 interleukin 6 Homo sapiens 94-97 10880263-6 2000 Blocking protein tyrosine kinase (PTK) activation by herbimycin A or genistein, or blocking NF-kappaB activation by pyrrolidinedithiocarbamate, reduced the IL-6 expression induced by TNF-alpha, IL-1beta and OSM. Genistein 69-78 interleukin 6 Homo sapiens 156-160 10996035-4 2000 Of the Th2 cytokines, the amounts of IL-6 and IL-10 induced by AILb-A were lower than those by OK-432. ailb-a 63-69 interleukin 6 Homo sapiens 37-41 10969791-4 2000 When exposed to interleukin 6, interleukin 1beta, tumor necrosis factor alpha, and prostaglandin E2, DCs containing apoptotic MEL-397 cell material matured normally [cross-presenting DCs (cp-DCs)]. cp-dcs 188-194 interleukin 6 Homo sapiens 16-29 10880263-6 2000 Blocking protein tyrosine kinase (PTK) activation by herbimycin A or genistein, or blocking NF-kappaB activation by pyrrolidinedithiocarbamate, reduced the IL-6 expression induced by TNF-alpha, IL-1beta and OSM. pyrrolidine dithiocarbamic acid 116-142 interleukin 6 Homo sapiens 156-160 20138527-5 2010 Synthesized compounds 4g and 4h revealed promising anti-inflammatory activity (66-67% TNF-alpha and 95-97% IL-6 inhibitory activity at 10 microM). 4h 29-31 interleukin 6 Homo sapiens 107-111 10903342-5 2000 Surprisingly, reduction of EPOR expression using antisense oligodeoxynucleotides suppressed erythropoiesis stimulated not only by SCF and EPO, but also by SCF, sIL-6R, and IL-6. Oligodeoxyribonucleotides 59-80 interleukin 6 Homo sapiens 161-165 10913935-7 2000 The time course of IL-6 and FT(3 )concentration seemed to be closely linked. Tegafur 28-30 interleukin 6 Homo sapiens 19-23 19923143-6 2010 Staurosporine and PD98059 synergistically reduced the effect of HG on IL-6, CCL-2 and TGF-beta expression. Staurosporine 0-13 interleukin 6 Homo sapiens 70-74 10826501-4 2000 The ET-A-receptor antagonist BQ-123 (10 microM), but not the ET-B-receptor antagonist BQ-788, inhibited IL-6 release. cyclo(Trp-Asp-Pro-Val-Leu) 29-35 interleukin 6 Homo sapiens 104-108 10826501-7 2000 A decoy oligodeoxynucleotide bearing the NF-kappaB binding site inhibited ET-1-stimulated IL-6 release to a great extent suggesting that this transcription factor plays a key role for cytokine production elicited by ET-1. Oligodeoxyribonucleotides 8-28 interleukin 6 Homo sapiens 90-94 20716936-8 2010 BAFF levels were also significantly correlated with the other B cell-activating cytokines IL-6 [r = 0.882, P<0.001] and IL-13 [r = 0.659, P<0.001].The antigen-induced production of BAFF in the lung of active BD with pulmonary manifestations might contribute to immunoglobulin synthesis by B cells. baff 0-4 interleukin 6 Homo sapiens 90-94 10826501-8 2000 Moreover, the antioxidant pyrrolidine dithiocarbamate (10 microM) inhibited ET-1-induced IL-6 release indicating involvement of reactive oxygen species in ET-1 signaling. pyrrolidine dithiocarbamic acid 26-53 interleukin 6 Homo sapiens 89-93 10823386-3 2000 MAIN RESULTS: Catecholamines (epinephrine, norepinephrine, isoproterenol, and dopamine) in general inhibit tumor necrosis factor-alpha (TNF) production and may enhance interleukin-6 (IL-6) and IL-10 production. Isoproterenol 59-72 interleukin 6 Homo sapiens 168-181 10816522-6 2000 Furthermore, inhibition of bacterial protein synthesis with chloramphenicol prevented up-regulation of IL-6 and bFGF in infected cells. Chloramphenicol 60-75 interleukin 6 Homo sapiens 103-107 20005571-7 2010 By contrast, STBM washed from the maternal side of a placental cotyledon and STBM shed by explants cultured in air up-regulated cell surface expression of the adhesion molecule CD54 and induced the production of interleukin (IL)-8, IL-6 and IL-1beta. stbm 13-17 interleukin 6 Homo sapiens 232-236 10997642-3 2000 MEASUREMENTS: Plasma IL-6 and TNFalpha responses to isoprenaline infusion. Isoproterenol 52-64 interleukin 6 Homo sapiens 21-25 10997642-8 2000 Differentiated adipocytes incubated in isoprenaline (0-0.1 microM) released significantly increased amounts of IL-6 whereas no response was elicited from PBC. Isoproterenol 39-51 interleukin 6 Homo sapiens 111-115 10719304-13 2000 GQ1b-induced increases in IL-6 and IL-10 production of T cells were both blocked by PKC inhibitors, calphostin C and staurosporine. Staurosporine 117-130 interleukin 6 Homo sapiens 26-30 11188934-3 2000 Thalidomide has been shown to block the activity of angiogenic substances like bFGF, VEGF and interleukin 6. Thalidomide 0-11 interleukin 6 Homo sapiens 94-107 10632966-0 2000 Omega-3 fatty acids enhance ligament fibroblast collagen formation in association with changes in interleukin-6 production. Fatty Acids, Omega-3 0-19 interleukin 6 Homo sapiens 98-111 20005571-7 2010 By contrast, STBM washed from the maternal side of a placental cotyledon and STBM shed by explants cultured in air up-regulated cell surface expression of the adhesion molecule CD54 and induced the production of interleukin (IL)-8, IL-6 and IL-1beta. stbm 77-81 interleukin 6 Homo sapiens 232-236 10590238-7 1999 OSM stimulated the release of IL-6 by hASMCs in a dose-dependent way; after a 48-hour exposure, values were 8.5+/-0.7, 29.7+/-3.5, 50.9+/-4.4, and 73.8+/-7.6x10(3) U/mL (n=6) at OSM concentrations of 0, 1, 10, and 100 ng/mL, respectively. hasmcs 38-44 interleukin 6 Homo sapiens 30-34 21063104-9 2010 In contrast, endothelial cells showed higher IL-6 and IL-8 release under co-culture conditions than in monolayers, with IL-8 production being largely suppressed by L-NMMA but not by 4-ABH(4). N(G)-monomethylarginine acetate 164-170 interleukin 6 Homo sapiens 45-49 10657942-4 2000 Northern blotting and metabolic labeling studies revealed that IL-6 with or without DEX upregulates gammaFBG messenger RNA and protein, whereas IL-1beta inhibits gammaFBG expression in human lung (A549) and liver (HepG2) epithelial cells. gammafbg 100-108 interleukin 6 Homo sapiens 63-67 10602426-2 1999 H-IL-6, which acts on both IL-6Ralpha-positive and IL-6Ralpha-negative cells, effectively synergized with FL and TPO with or without SCF for the propagation of primitive progenitors. fl 106-108 interleukin 6 Homo sapiens 2-6 10602426-3 1999 However, IL-6 showed a greater synergistic effect with FL and TPO than H-IL-6 for long-term progenitor propagation. fl 55-57 interleukin 6 Homo sapiens 9-13 10438958-9 1999 Paraformaldehyde-fixed CD40L-activated monocytes (to preserve membrane integrity but prevent secretory activity), cocultured with MC at various ratios, induced IL-6, MCP-1, and ICAM-1 synthesis by MC. paraform 0-16 interleukin 6 Homo sapiens 160-164 10438468-6 1999 Inhibition of PI 3-kinase by wortmannin or LY294002 abolished the protection of IL-6 against TGF-beta-induced apoptosis. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 43-51 interleukin 6 Homo sapiens 80-84 10438468-9 1999 Finally, inhibition of both STAT3 and PI 3-kinase by treating cells overexpressing the dominant-negative STAT3 with LY294002 completely blocked IL-6-induced survival signal. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 116-124 interleukin 6 Homo sapiens 144-148 19907186-6 2010 In addition, the H1R antagonist olopatadine significantly blocked histamine-induced production of IL-6, whereas the H2R antagonist ranitidine did not. Olopatadine Hydrochloride 32-43 interleukin 6 Homo sapiens 98-102 10445543-6 1999 In individual patients serum IL-6 levels correlated with corresponding CDAI scores in a subgroup referred to as primarily inflammatory patients presenting without bowel stenosis, previous intestinal resection, or concomitant inflammatory disorders (r = 0.72, p < 0.001). cdai 71-75 interleukin 6 Homo sapiens 29-33 10326962-4 1999 RESULTS: Antazoline hydrochloride, emedastine difumarate, levocabastine hydrochloride, olopatadine hydrochloride, and pheniramine maleate attenuated histamine-stimulated phosphatidylinositol turnover and IL-6 and IL-8 secretion. Olopatadine Hydrochloride 87-112 interleukin 6 Homo sapiens 204-208 20391135-11 2010 Indeed, 1-methylpyrene or perylene, individually or when combined, significantly upregulated IL-1alpha and IL-6 secretion. 1-methylpyrene 8-22 interleukin 6 Homo sapiens 107-111 10326962-5 1999 Emedastine was the most potent in ligand binding, phosphatidylinositol turnover, and IL-6 secretion, with dissociation constant and 50% inhibitory concentrations of 1-3 nmol/L. emedastine 0-10 interleukin 6 Homo sapiens 85-89 10362412-7 1999 IL-6 accumulation was decreased (p < .05) and IL-8 accumulation increased (p < .01) with L-NMMA. N(G)-monomethylarginine acetate 95-101 interleukin 6 Homo sapiens 0-4 10542243-6 1999 Moreover, treatment of chromatin-integrated promoter constructions with the histone deacetylase inhibitor trichostatin A exclusively potentiates TNF-dependent (i.e. NF-kappaB-mediated) gene activation, while basal or STS-stimulated IL-6 promoter activity remains completely unchanged. trichostatin A 106-120 interleukin 6 Homo sapiens 232-236 19766327-4 2009 The current study investigated the effects of luteolin, a citrus bioflavonoid, and its structural analog, diosmin, on IL-6 induced JAK2/STAT3 (Janus tyrosine kinase-2/signal transducer and activator of transcription-3) phosphorylation and signaling as well as behavioral phenotypes of MIA offspring. Diosmin 106-113 interleukin 6 Homo sapiens 118-122 10598880-0 1999 Activation of cellular responses to interleukin 6 is blocked by staurosporine. Staurosporine 64-77 interleukin 6 Homo sapiens 36-49 10598880-2 1999 The effects of the microbial alkaloid staurosporine (SS) on IL-6 signaling through gp130, and also on the internalization of the IL-6 receptor complex, were studied using HepG2 cells which are well-characterized in their ability to respond to IL-6 by upregulating acute-phase protein production. Staurosporine 53-55 interleukin 6 Homo sapiens 60-64 10598880-3 1999 SS was found effective in the blockade of the signaling cascade of IL-6: phosphorylation of both gp130 and Stat3 was eliminated by SS treatment and the production of IL-6 stimulated haptoglobin by the cells was abolished. Staurosporine 0-2 interleukin 6 Homo sapiens 67-71 10598880-3 1999 SS was found effective in the blockade of the signaling cascade of IL-6: phosphorylation of both gp130 and Stat3 was eliminated by SS treatment and the production of IL-6 stimulated haptoglobin by the cells was abolished. Staurosporine 0-2 interleukin 6 Homo sapiens 166-170 10598880-6 1999 The ability of SS to void the capacity of IL-6, and IL-6-related cytokines such as Oncostatin M, to deliver growth and differentiation signals may be one process by which this agent could promote apoptosis in a variety of cell types. Staurosporine 15-17 interleukin 6 Homo sapiens 42-46 10598880-6 1999 The ability of SS to void the capacity of IL-6, and IL-6-related cytokines such as Oncostatin M, to deliver growth and differentiation signals may be one process by which this agent could promote apoptosis in a variety of cell types. Staurosporine 15-17 interleukin 6 Homo sapiens 52-56 9873234-10 1999 The inhibition of IL-6 production by Am-80 was due to downregulation of the pretranscription or the transcription of IL-6 in MG 63 cells. tamibarotene 37-42 interleukin 6 Homo sapiens 18-22 9873234-10 1999 The inhibition of IL-6 production by Am-80 was due to downregulation of the pretranscription or the transcription of IL-6 in MG 63 cells. tamibarotene 37-42 interleukin 6 Homo sapiens 117-121 9921985-0 1999 Blocking signaling through the Gp130 receptor chain by interleukin-6 and oncostatin M inhibits PC-3 cell growth and sensitizes the tumor cells to etoposide and cisplatin-mediated cytotoxicity. Etoposide 146-155 interleukin 6 Homo sapiens 55-68 9921985-4 1999 RESULTS: Both endogenous and exogenous IL-6 and exogenous OM up-regulated cell growth and enhanced resistance of PC-3 tumor cells to both etoposide and cisplatin. Etoposide 138-147 interleukin 6 Homo sapiens 39-43 9921985-7 1999 Both IL-6- and OM-mediated effects are inhibited by the treatment of PC-3 with an antisense oligodeoxynucleotide against gp130, the protein kinase inhibitor genistein (GNS), or the monoterpene perillic acid (PA), a posttranslational inhibitor of p21ras isoprenylation. Oligodeoxyribonucleotides 92-112 interleukin 6 Homo sapiens 5-9 9921985-7 1999 Both IL-6- and OM-mediated effects are inhibited by the treatment of PC-3 with an antisense oligodeoxynucleotide against gp130, the protein kinase inhibitor genistein (GNS), or the monoterpene perillic acid (PA), a posttranslational inhibitor of p21ras isoprenylation. Genistein 157-166 interleukin 6 Homo sapiens 5-9 9921985-7 1999 Both IL-6- and OM-mediated effects are inhibited by the treatment of PC-3 with an antisense oligodeoxynucleotide against gp130, the protein kinase inhibitor genistein (GNS), or the monoterpene perillic acid (PA), a posttranslational inhibitor of p21ras isoprenylation. Genistein 168-171 interleukin 6 Homo sapiens 5-9 19549135-8 2009 RESULTS: Among four groups, CP&T2DM group showed the lowest IL-6-572 CC genotype and C-allele frequencies (54.5% and 74.1%). cp& 28-34 interleukin 6 Homo sapiens 64-68 10421684-10 1999 PE particles stimulated the expression of IL-1beta, IL-6, and TNF-alpha in the BHC model. pe 0-2 interleukin 6 Homo sapiens 52-56 10467277-4 1999 In a subsequent challenge test with CBZ, platelet counts again decreased, and the levels of platelet-associated IgG and serum interleukin-6 increased. Carbamazepine 36-39 interleukin 6 Homo sapiens 126-139 10405348-9 1999 Both paclitaxel and 2-meOE2 also inhibited stimulation of aromatase activity by IL-6 plus its soluble receptor and PGE(2). 2-Methoxyestradiol 20-27 interleukin 6 Homo sapiens 80-84 19549135-11 2009 CONCLUSIONS: The IL-6-572 genotype and allele distributions are unique to subjects with CP&T2DM in a Chinese population. cp& 88-94 interleukin 6 Homo sapiens 17-21 10397679-11 1999 Pyrrolidine dithiocarbamate suppressed angiotensin II-induced IL-6 release, a finding compatible with involvement of reactive oxygen species as second messengers in cytokine production mediated by angiotensin. pyrrolidine dithiocarbamic acid 0-27 interleukin 6 Homo sapiens 62-66 9882597-11 1999 BEAS-2B cells, pretreated with amiloride before ROFA exposure, showed a partial (approximately 25%) reduction of IL-6. Amiloride 31-40 interleukin 6 Homo sapiens 113-117 19690161-0 2009 Complex N-linked glycans on Asn-89 of Kaposi sarcoma herpes virus-encoded interleukin-6 mediate optimal function by affecting cytokine protein conformation. n-linked glycans 8-24 interleukin 6 Homo sapiens 74-87 9788508-4 1998 NiCl2 and CoCl2 upregulate, especially in concentrations of 1 mM, the expression of adhesion molecules (e.g., E-selectin and intercellular adhesion molecule-1), as well as the cytokines IL-6 and IL-8, as shown by enzyme immunoassay and Northern blot analysis. nickel chloride 0-5 interleukin 6 Homo sapiens 186-190 10401557-8 1999 Moreover, rolipram significantly potentiated hyperalgesia induced by carrageenan, bradykinin, TNF alpha, IL-1 beta, IL-6 and IL-8. Rolipram 10-18 interleukin 6 Homo sapiens 116-120 10226093-2 1999 We investigated the underlying molecular mechanism responsible for IL-6 induction in response to the CCB amlodipine, diltiazem, and verapamil in primary human vascular smooth muscle cells (VSMC). Verapamil 132-141 interleukin 6 Homo sapiens 67-71 19690161-0 2009 Complex N-linked glycans on Asn-89 of Kaposi sarcoma herpes virus-encoded interleukin-6 mediate optimal function by affecting cytokine protein conformation. Asparagine 28-31 interleukin 6 Homo sapiens 74-87 9858064-4 1998 Both indomethacin and M-5011 augmented interleukin (IL)-2 production, whereas they suppressed IL-6 production both at the protein and mRNA levels. 2-(4-(3-methyl-2-thienyl)phenyl)propionic acid 22-28 interleukin 6 Homo sapiens 94-98 20074471-3 2009 The aim of this study is to investigate whether tetrabromofluorecin, commonly know as eosin, a classical compound traditionally topically used in psoriasis for its presumed anti-inflammatory activities, is able to modulate the production of TNF-alpha, IL-6 and IL-8 that are recognized as the most active and characterized cytokines in the pathogenesis of this skin disorder. Eosine Yellowish-(YS) 86-91 interleukin 6 Homo sapiens 252-256 9789288-10 1998 PMX treatment improves the symptoms related to the septic state, a hemodynamic disorders, and cytokine levels including tumor mecrosis factor, interleukin (IL)-6, and IL-10, with a decrease in endotoxin levels. (+)-xylariamide A 0-3 interleukin 6 Homo sapiens 143-161 10505115-7 1999 Likewise, the CpG oligodeoxynucleotides 1760 (phosphorothioate) and 2059 (unmodified) induced IL-6 synthesis, but the corresponding control oligonucleotides 1908 and 2077 did not CpG DNA and LPS enhanced IL-6 synthesis synergistically. Oligodeoxyribonucleotides 18-39 interleukin 6 Homo sapiens 94-98 10505115-7 1999 Likewise, the CpG oligodeoxynucleotides 1760 (phosphorothioate) and 2059 (unmodified) induced IL-6 synthesis, but the corresponding control oligonucleotides 1908 and 2077 did not CpG DNA and LPS enhanced IL-6 synthesis synergistically. Oligodeoxyribonucleotides 18-39 interleukin 6 Homo sapiens 204-208 20074471-8 2009 The expression and production of TNFalpha, IL-8 and IL-6 were dramatically reduced in presence of eosin 0.05% and 0.02% and the action of eosin was more pronounced on TNF-alpha. Eosine Yellowish-(YS) 98-103 interleukin 6 Homo sapiens 52-56 19580863-0 2009 Role of IL-1 beta and COX2 in silica-induced IL-6 release and loss of pneumocytes in co-cultures. Silicon Dioxide 30-36 interleukin 6 Homo sapiens 45-49 10191209-5 1999 CMV-UV-stimulated IL-6 was inhibited by pyrrolidinedithiocarbamate (an inhibitor of the transcription factor, NF-kappaB) and by pertussis toxin (suggesting the involvement of a G protein) and occurred in the absence of CMV immediate-early antigen transcription. pyrrolidine dithiocarbamic acid 40-66 interleukin 6 Homo sapiens 18-22 9624502-2 1998 Roxithromycin suppressed production of interleukin 8 (IL-8), IL-6, and granulocyte-macrophage colony-stimulating factor. Roxithromycin 0-13 interleukin 6 Homo sapiens 61-119 19580863-1 2009 The pro-inflammatory cytokines IL-1 beta, TNF-alpha and IL-6 are of great importance in the development of silica-induced lung damage and repair. Silicon Dioxide 107-113 interleukin 6 Homo sapiens 56-60 10202034-2 1999 Freshly isolated monocytes treated with the protein phosphatase inhibitor okadaic acid secreted high levels of IL-6 protein, which coincided with enhanced binding activity of NF-kappa B as well as with phosphorylation and activation of the ERK1/2 and JNK proteins. Okadaic Acid 74-86 interleukin 6 Homo sapiens 111-115 10202034-7 1999 We conclude that okadaic acid-induced IL-6 gene expression is at least partly mediated through the ERK1/2 and JNK pathway-dependent activation of NF-kappa B transcriptional capacity. Okadaic Acid 17-29 interleukin 6 Homo sapiens 38-42 19580863-2 2009 In this study we investigated the role of IL-1 beta, TNF-alpha and COX2 in silica-induced regulation of IL-6 release and pneumocyte loss in various mono- and co-cultures of monocytes, pneumocytes and endothelial cells. Silicon Dioxide 75-81 interleukin 6 Homo sapiens 104-108 9605146-8 1998 Cyanoketone blocked the stress-induced rise in IL-6 mRNA and protein expression in the trigeminal ganglion latently infected with HSV-1. Cyanoketone 0-11 interleukin 6 Homo sapiens 47-51 19580863-3 2009 All co-cultures with monocytes, and especially cultures including endothelial cells, showed an increase of silica-induced release of IL-6 compared to the respective monocultures. Silicon Dioxide 107-113 interleukin 6 Homo sapiens 133-137 9566351-3 1998 Emedastine potently inhibited histamine-induced IL-6, IL-8 and GM-CSF secretion with mean IC50 values of 2.23, 3.42 and 1.50 nM, respectively. emedastine 0-10 interleukin 6 Homo sapiens 48-52 19700754-8 2009 Furthermore, the Th17-centric cytokines IL-17, IL-6, IL-23, and IL-12 were significantly elevated in pSS plasma. pss 101-104 interleukin 6 Homo sapiens 47-51 9523575-5 1998 Whereas the antioxidant pyrrolidinedithiocarbamate was only able to inhibit IL-1beta-induced IL-6 expression, inhibition of protein kinase C prevented IL-6 expression induced by all three substances. pyrrolidine dithiocarbamic acid 24-50 interleukin 6 Homo sapiens 93-97 9408252-0 1997 Interleukin (IL)-6 and IL-8 production by human amnion: regulation by cytokines, growth factors, glucocorticoids, phorbol esters, and bacterial lipopolysaccharide. Phorbol Esters 114-128 interleukin 6 Homo sapiens 0-18 10213368-11 1999 Microparticles prepared from either chitosan or starch microparticles, applied apically, induced the basolateral release of IL-6 and IL-8 from polarized Calu-3 cells. Starch 48-54 interleukin 6 Homo sapiens 124-128 10327575-8 1999 Patients with glutamine substitution showed non significantly decreased systemic inflammation (IL-6-plasma levels, leucocytosis) and significantly faster compensation of postoperative immunosuppression (HLA-DR-monocytes). Glutamine 14-23 interleukin 6 Homo sapiens 95-99 19723085-6 2009 We found that omega-3 fatty acids, such as docosahexaenoic acid (DHA) and alpha-linolenic acid (ALA), suppressed the expression of inflammatory cytokines (IL-1beta, IL-6) and inhibited the activation of transcription factor activator protein-1 in cerulein-stimulated pancreatic acinar cells. Fatty Acids, Omega-3 14-33 interleukin 6 Homo sapiens 165-169 9875327-5 1998 In contrast, induction of IL-6 and ICAM-1 by IL-1 is intact in EZ-infected cells. ez 63-65 interleukin 6 Homo sapiens 26-30 9394834-9 1997 In spite of the augmented CD86 expression on DC treated with DNCB or NiCl2, these chemicals induced different responses of DC in their expression of CD54 and HLA-DR and the production of IL-6 and tumor necrosis factor (TNF)-alpha. nickel chloride 69-74 interleukin 6 Homo sapiens 187-191 9393919-3 1997 Particles of titanium-6-aluminium-4-vanadium (TiAIV) stimulated MNP to release interleukin (IL)-1beta, tumour necrosis factor (TNF)alpha, IL-6 and prostaglandin E2 (PGE2). titanium-6-aluminium-4-vanadium 13-44 interleukin 6 Homo sapiens 138-142 19698226-5 2009 The combination of THD in concentration of 80 or 100 microg/ml with Dx in concentration of 4 microg/ml decreased the expression of IL-6, TNF-alpha and survivin, increased the expression of ES, while no influence on VEGF expression was found. Thalidomide 19-22 interleukin 6 Homo sapiens 131-135 9359732-2 1997 CNI-1493 inhibited lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-alpha, interleukin (IL)-1alpha, IL-1beta, IL-6, and IL-8 production whether or not LPS stimulation was enhanced by interferon (IFN)-gamma priming. semapimod 0-8 interleukin 6 Homo sapiens 122-126 9352014-0 1997 Regulation of interleukin (IL)-6 and IL-8 production in an amnion-derived cell line by cytokines, growth factors, glucocorticoids, and phorbol esters. Phorbol Esters 135-149 interleukin 6 Homo sapiens 14-32 9378738-9 1997 Phosphodiesterase inhibitors, such as isobutyryl methylxanthine and pentoxifylline, which increase intracellular levels of cAMP, caused a decrease in the production of tumor necrosis factor-alpha and an increase in the production of interleukin-6. isobutyryl methylxanthine 38-63 interleukin 6 Homo sapiens 233-246 9788616-6 1998 We show that IL-6 up-regulates AR activity in a ligand-independent manner, as well as synergistically, with very low doses of the synthetic androgen methyltrienolone (5-10 pM). Metribolone 149-165 interleukin 6 Homo sapiens 13-17 9788616-8 1998 The maximal induction of reporter gene activity by IL-6 alone (50 ng/ml) was 67% of that stimulated by 1 nM of methyltrienolone. Metribolone 111-127 interleukin 6 Homo sapiens 51-55 19698226-6 2009 It is concluded that THD combined with Dx shows the synergistic inhibitory effect on KM3 cells, they bring the effect resistant to multiple myeloma probably through down-regulating the expression of IL-6, TNF-alpha and survivin, and up-regulating the expression of ES in KM3 cell. Thalidomide 21-24 interleukin 6 Homo sapiens 199-203 19434061-7 2009 Endogenous and TNF-alpha-induced expressions of IL-6, IL-8, p38, p65 and C/EBP-beta were also downregulated by genistein, showing its anti-inflammatory properties. Genistein 111-120 interleukin 6 Homo sapiens 48-52 9744647-5 1998 Average levels of proinflammatory cytokines (IL-1beta, IL-6, IL-8, and TNFalpha) were greater with Fragmin anticoagulation for 36 of 40 comparisons, and patterns were similar for 6 h and 24 h incubations. Dalteparin 99-106 interleukin 6 Homo sapiens 55-59 9355962-8 1997 It was established that AE-22 can induce TNF-alpha, IL-6, and IFN-gamma in a dose-dependent manner in BAL cells and PBL isolated from healthy individuals. NSC639782 24-29 interleukin 6 Homo sapiens 52-56 19155534-7 2009 The upregulated gene expression and protein synthesis of IL-6 and ATR1 in PTEC induced by the IgA-HMC conditioned medium were readily attenuated following pre-treatment with a PPAR-gamma agonist, thiazolidinedione (TZD). 2,4-thiazolidinedione 196-213 interleukin 6 Homo sapiens 57-61 9338137-0 1997 Amphotericin B augments interleukin-6 production by human gingival fibroblasts in vitro. Amphotericin B 0-14 interleukin 6 Homo sapiens 24-37 9273875-0 1997 Metal fume fever: characterization of clinical and plasma IL-6 responses in controlled human exposures to zinc oxide fume at and below the threshold limit value. Zinc Oxide 106-116 interleukin 6 Homo sapiens 58-62 9273875-7 1997 In a parallel fashion, plasma levels of interleukin 6 (IL-6), a pyrogen, were significantly elevated after exposure to 5 mg/m3 zinc oxide. Zinc Oxide 127-137 interleukin 6 Homo sapiens 40-53 9273875-7 1997 In a parallel fashion, plasma levels of interleukin 6 (IL-6), a pyrogen, were significantly elevated after exposure to 5 mg/m3 zinc oxide. Zinc Oxide 127-137 interleukin 6 Homo sapiens 55-59 9690225-9 1998 RESULTS: Compared to the control group, PBMC from uremic patients on conservative therapy and treated by CU showed a clear reduction in the cytokine release, while PMMA and PA membranes were able to normalize IL-6, IL-8 and MCP-1 protein concentration, which had been reduced by CU treatment. cuprammonium cellulose 105-107 interleukin 6 Homo sapiens 209-213 9648083-9 1998 The concentration of IL-6 in the supernatant of stimulated monocytes was highest with Glu/Bic (1023 +/- 278 pg/ml) and Amino/Bic (776 +/- 296 pg/ml) an lowest with Glu/lac pH 5.5 (46 +/- 22 pg/ml) and Glu-poly/PBS (32 +/- 13 pg/ml). poly 205-209 interleukin 6 Homo sapiens 21-25 9273875-12 1997 Inhalation of zinc oxide for 2 hours at the current TLV of 5 mg/m3 produces fever and symptoms along with elevation in plasma IL-6 levels. Zinc Oxide 14-24 interleukin 6 Homo sapiens 126-130 19155534-7 2009 The upregulated gene expression and protein synthesis of IL-6 and ATR1 in PTEC induced by the IgA-HMC conditioned medium were readily attenuated following pre-treatment with a PPAR-gamma agonist, thiazolidinedione (TZD). 2,4-thiazolidinedione 215-218 interleukin 6 Homo sapiens 57-61 19452017-9 2009 RESULTS: The expressions of MIP1-alpha, MIP1-beta, IL-6, IL-8, RANTES, IFN-beta, and TLR3 were up-regulated in HCECs exposed to poly(I:C). poly 128-132 interleukin 6 Homo sapiens 51-55 9253958-2 1997 Anandamide was shown to diminish interleukin-6 and interleukin-8 production at low nanomolar concentrations (3-30 nM) but inhibited the production of TNF-alpha, interferon-gamma, interleukin-4 and p75 TNF-alpha soluble receptors at higher concentrations (0.3-3 microM). anandamide 0-10 interleukin 6 Homo sapiens 33-46 9199508-3 1997 In the endometrial adenocarcinoma cell line Ishikawa, phorbol ester-induced activation of the IL-6 promoter was inhibited to basal levels by 17 beta-estradiol (E2) in a wild-type receptor-dependent fashion. Phorbol Esters 54-67 interleukin 6 Homo sapiens 94-98 9581864-2 1998 In the present study, we investigated the effect of tiludronate, a bisphosphonate known to inhibit bone resorption, on the PGF2alpha- and PGE1-induced IL-6 synthesis in these cells. tiludronic acid 52-63 interleukin 6 Homo sapiens 151-155 9581864-9 1998 Tiludronate significantly inhibited the NaF-induced IL-6 secretion in human osteoblastic osteosarcoma Saos-2 cells. tiludronic acid 0-11 interleukin 6 Homo sapiens 52-56 9581864-10 1998 These results strongly suggest that tiludronate inhibits PGF2alpha-induced IL-6 synthesis via suppression of phosphatidylcholine-hydrolyzing phospholipase D activation in osteoblasts, and that the inhibitory effect is exerted at the point between heterotrimeric GTP-binding protein and phospholipase D. tiludronic acid 36-47 interleukin 6 Homo sapiens 75-79 9516148-10 1998 Experiments using antisense oligonucleotides showed that the clonal growth of KS-1 and BC-1 was nearly 100% inhibited by IL-6 antisense oligonucleotides (10 micromol/L), but not at all by either oligonucleotides (</=10 micromol/L) to IL-6 sense, IL-6 scrambled, viral IL-6 (vIL-6) antisense, or IL-10 antisense. vil 277-280 interleukin 6 Homo sapiens 121-125 19325469-13 2009 CONCLUSIONS: Stress doses of hydrocortisone attenuate the evolution of IL-6/IL-10 ratio in patients with systemic inflammatory response syndrome after CS, which seems to be associated with an improved outcome. Cesium 151-153 interleukin 6 Homo sapiens 71-75 9695746-9 1998 To determine if changes in elastase release might be due to IL-6 induced generation of PAF, WEB 2347 (50 microM) was preincubated with selected cells for 20 min. Platelet Activating Factor 87-90 interleukin 6 Homo sapiens 60-64 19469019-7 2009 Array analysis revealed that DHMEQ down-regulated expression levels of NF-kappaB target genes, such as interleukin-6 (IL6), Myc, chemokine (C-C motif) receptor 5 (CCR5) and NF-kappaB1, whereas it up-regulated expression levels of some genes involved in apoptosis, and cell cycle arrest. dehydroxymethylepoxyquinomicin 29-34 interleukin 6 Homo sapiens 103-116 9545547-6 1998 Administration of diethyldithiocarbamate (DDC) inhibited induction of NF-kappa B and concomitantly the expression of IL-1 beta, IL-6, TNF-alpha as well as iNOS. Ditiocarb 18-40 interleukin 6 Homo sapiens 128-132 9545547-6 1998 Administration of diethyldithiocarbamate (DDC) inhibited induction of NF-kappa B and concomitantly the expression of IL-1 beta, IL-6, TNF-alpha as well as iNOS. Ditiocarb 42-45 interleukin 6 Homo sapiens 128-132 16844584-0 1997 Stimulatory effect of glutamine on human monocyte activation as measured by interleukin-6 and soluble interleukin-6 receptor release. Glutamine 22-31 interleukin 6 Homo sapiens 76-89 16844584-0 1997 Stimulatory effect of glutamine on human monocyte activation as measured by interleukin-6 and soluble interleukin-6 receptor release. Glutamine 22-31 interleukin 6 Homo sapiens 102-115 16844584-6 1997 The extracellular glutamine concentration had a significant effect on IL-6 secretion by activated human monocytes. Glutamine 18-27 interleukin 6 Homo sapiens 70-74 16844584-7 1997 The mean levels of IL-6 in 0.1 mM glutamine were only marginally higher (P = 0.54) compared to those in the absence of glutamine. Glutamine 34-43 interleukin 6 Homo sapiens 19-23 16844584-8 1997 A minimum of 0.2 mM glutamine was required to reach the maximal production of IL-6. Glutamine 20-29 interleukin 6 Homo sapiens 78-82 16844584-9 1997 At all glutamine concentrations the higher concentration of LPS (1 ng/ml) induced higher mean levels of IL-6 than the lower one (1 pg/ml). Glutamine 7-16 interleukin 6 Homo sapiens 104-108 16844584-11 1997 Our results indicate that very low levels of glutamine in plasma may impair the activation of human monocytes as measured by IL-6 secretion. Glutamine 45-54 interleukin 6 Homo sapiens 125-129 20492795-3 1998 We followed the influence of Methylprednisolon (Solumedrol, UpJohn) therapy to the IL-6 level in blood and liquor, as the supposed selective mediator for spinal trauma. Methylprednisolone Hemisuccinate 48-58 interleukin 6 Homo sapiens 83-87 19469019-7 2009 Array analysis revealed that DHMEQ down-regulated expression levels of NF-kappaB target genes, such as interleukin-6 (IL6), Myc, chemokine (C-C motif) receptor 5 (CCR5) and NF-kappaB1, whereas it up-regulated expression levels of some genes involved in apoptosis, and cell cycle arrest. dehydroxymethylepoxyquinomicin 29-34 interleukin 6 Homo sapiens 118-121 20492795-4 1998 In investigated group we documented the positive influence of Solumedrol therapy to final neurological status and significant decrease of IL-6 liquor concentration in this patients. Methylprednisolone Hemisuccinate 62-72 interleukin 6 Homo sapiens 138-142 19225954-0 2009 Postoperative PMBC-derived IL-6 and TNF-alpha-release is uninfluenced by IL-12-mediated restoration of IFN-gamma synthesis. pmbc 14-18 interleukin 6 Homo sapiens 27-31 9475357-1 1998 Whole-cell pertussis found in diphtheria-tetanus-pertussis (DTP) vaccine can produce symptoms reminiscent of biological responses to circulating proinflammatory monokines such as IL-6, IL-1beta, and TNFalpha. diphtheria-tetanus-pertussis 30-58 interleukin 6 Homo sapiens 179-183 9184081-6 1997 An increase in cyclin B1 expression was also observed in irradiated HSF cells (synchronous and asynchronous), which decreased when the cells were treated with staurosporine or caffeine. Staurosporine 159-172 interleukin 6 Homo sapiens 68-71 19215278-8 2009 Retinol, RBP and adipose tissue RBP messenger RNA (mRNA) levels shared an inverse relationship with plasma interleukin-6, and adipose tissue RBP mRNA levels correlated positively with plasma tumour necrosis factor-alpha (TNF-alpha) and skeletal muscle TNF-alpha mRNA levels. Vitamin A 0-7 interleukin 6 Homo sapiens 107-120 9124553-5 1997 ET-1-stimulated IL-6 production was blocked by the inhibitor BQ-123, implicating ET(A) receptor involvement. cyclo(Trp-Asp-Pro-Val-Leu) 61-67 interleukin 6 Homo sapiens 16-20 9135506-0 1997 Acute effects of pamidronate administration on serum levels of interleukin-6 in advanced solid tumour patients with bone metastases and their possible implications in the immunotherapy of cancer with interleukin-2. Pamidronate 17-28 interleukin 6 Homo sapiens 63-76 9610004-1 1998 A polymorphic dinucleotide (CA) sequence was isolated from a genomic clone containing the human interleukin 6 (interferon beta-2) gene and was mapped to 7p21. Dinucleoside Phosphates 14-26 interleukin 6 Homo sapiens 96-128 9356189-7 1997 Zinc oxide exposure was a statistically significant, dose-dependent predictor of increases in BAL TNF (mean exposure-sham difference +/- SE = 9.5 +/- 3.6 pg/mL, P = 0.02), IL-6 (mean exposure-sham difference +/- SE = 5.5 +/- 1.8 pg/mL, P = 0.009), and IL-8 (mean exposure-sham difference +/- SE = 64.1 +/- 23.9 pg/mL, P = 0.02). Zinc Oxide 0-10 interleukin 6 Homo sapiens 172-176 19333898-3 2009 Preclinical studies of R-406 or fostamatinib demonstrated a significant reduction in major inflammatory mediators such as TNFalpha, IL-1, IL-6 and IL-18, leading to reduced inflammation and bone degradation in models of RA. fostamatinib 32-44 interleukin 6 Homo sapiens 138-142 9280289-3 1997 Furthermore, generating singlet oxygen outside the cells by irradiation of rose bengal-coated resin particles with visible light (lambda > 450 nm) results in the induction of interstitial collagenase, IL-1 and IL-6, similar to the response observed with UVA irradiation. Singlet Oxygen 24-38 interleukin 6 Homo sapiens 213-217 9280289-4 1997 These observations suggest that singlet oxygen is an early intermediate in the signaling pathway of IL-1 and IL-6 mediating UVA induction of interstitial collagenase (E.C. Singlet Oxygen 32-46 interleukin 6 Homo sapiens 109-113 9135506-5 1997 On this basis, a pilot study was performed to evaluate the in vivo effects of the bisphosphonate, pamidronate, on blood levels of IL-6. Pamidronate 98-109 interleukin 6 Homo sapiens 130-134 9135506-8 1997 Mean serum levels of IL-6 significantly decreased during pamidronate infusion, then after 1 and 3 days, IL-6 mean levels still remained lower than control level, but differences were not significant. Pamidronate 57-68 interleukin 6 Homo sapiens 21-25 9135506-9 1997 This preliminary study shows that pamidronate infusion induces a rapid but transient decline in IL-6 blood concentrations, and suggests a possible use of bisphosphonates to modulate the efficacy of IL-2 cancer immunotherapy. Pamidronate 34-45 interleukin 6 Homo sapiens 96-100 9547608-6 1997 The addition of n-3 PUFAs in culture medium (100 ug/ml DHA or EPA) significantly reduces the production of IL-6 by unstimulated EC; or stimulated with TNF-alpha; IL-4 pg/ml); LPS or depleted PBL respectively for DHA and EPA, whereas the n-6 PUFAs (Arachidonic acid), even used at the highest concentration, was ineffective. Fatty Acids, Omega-3 16-25 interleukin 6 Homo sapiens 107-111 22358535-4 1997 These results clearly demonstrate that phosphatidylcholine-specific phospholipase C is a key molecule mediating insulin-induced enhancement of hIL-6 expression from the human cytomegalovirus promoter in Chinese hamster ovary cells and strongly suggest that it plays an important role in the insulin signaling pathways.Abbreviations CHO - Chinese hamster ovary; hCMV promoter - immediate early gene promoter of human cytomegalovirus; hIL-6 - human interleukin 6; PC-PLC-phosphatidylcholine-specific phospholipase C; PI-3 kinase - phosphoinositide 3 kinase; PKA - cAMP dependent protein kinase; PKC - protein kinase C. Phosphatidylcholines 39-58 interleukin 6 Homo sapiens 143-148 9202212-3 1997 Using the tyrosine phosphorylation inhibitor, genistein, and electrophoretic mobility shift assay, we show that IL-6 and IFN-gamma induce nuclear factor STAT-3 and STAT-1 DNA-binding activity to the sis-inducible element of c-fos in a genistein-dependent pathway. Genistein 46-55 interleukin 6 Homo sapiens 112-116 19147572-6 2009 Finally, EGCG reduced the binding of p300 to the promoter region of interleukin-6 gene with an increased recruitment of HDAC3, which highlights the importance of the balance between HATs and histone deacetylases in the NF-kappaB-mediated inflammatory signaling pathway. epigallocatechin gallate 9-13 interleukin 6 Homo sapiens 68-81 9202212-3 1997 Using the tyrosine phosphorylation inhibitor, genistein, and electrophoretic mobility shift assay, we show that IL-6 and IFN-gamma induce nuclear factor STAT-3 and STAT-1 DNA-binding activity to the sis-inducible element of c-fos in a genistein-dependent pathway. Genistein 235-244 interleukin 6 Homo sapiens 112-116 9186223-5 1997 Cobalt at concentrations ranging from 0.1 to 100 ng/ml significantly enhanced the release of interleukin-6, but titanium and chromium did not. Cobalt 0-6 interleukin 6 Homo sapiens 93-106 22358535-4 1997 These results clearly demonstrate that phosphatidylcholine-specific phospholipase C is a key molecule mediating insulin-induced enhancement of hIL-6 expression from the human cytomegalovirus promoter in Chinese hamster ovary cells and strongly suggest that it plays an important role in the insulin signaling pathways.Abbreviations CHO - Chinese hamster ovary; hCMV promoter - immediate early gene promoter of human cytomegalovirus; hIL-6 - human interleukin 6; PC-PLC-phosphatidylcholine-specific phospholipase C; PI-3 kinase - phosphoinositide 3 kinase; PKA - cAMP dependent protein kinase; PKC - protein kinase C. Phosphatidylcholines 39-58 interleukin 6 Homo sapiens 433-438 9013264-0 1996 Interleukin-6 correlates with hemodynamic impairment during dobutamine administration in chronic heart failure. Dobutamine 60-70 interleukin 6 Homo sapiens 0-13 9013264-7 1996 In conclusion, in this pilot study IL6 correlates with the severity of chronic heart failure during low dose dobutamine infusion. Dobutamine 109-119 interleukin 6 Homo sapiens 35-38 8953156-7 1996 The release of IL-2 and IL-6 by PHA-stimulated PBMC was significantly inhibited by titanium, chromium, and cobalt. Cobalt 107-113 interleukin 6 Homo sapiens 24-28 18973761-4 2009 KEY FINDINGS: We found increased inflammation and secretion of the chemokines IL-6, MCP-1 and MIP-alpha 2 weeks after SiO2 application, and increased lung fibrosis after 3 months. Silicon Dioxide 118-122 interleukin 6 Homo sapiens 78-82 8959942-5 1996 Combination of transplantation of bone marrow derived from IL-6 treated donors with post-transplantation treatment of the recipients with IL-6 resulted in a further increase in nadir counts, although it did not cause a further acceleration of platelet reconstitution. nadir 177-182 interleukin 6 Homo sapiens 59-63 8959942-5 1996 Combination of transplantation of bone marrow derived from IL-6 treated donors with post-transplantation treatment of the recipients with IL-6 resulted in a further increase in nadir counts, although it did not cause a further acceleration of platelet reconstitution. nadir 177-182 interleukin 6 Homo sapiens 138-142 8896414-0 1996 Pyrrolidine dithiocarbamate inhibits the production of interleukin-6, interleukin-8, and granulocyte-macrophage colony-stimulating factor by human endothelial cells in response to inflammatory mediators: modulation of NF-kappa B and AP-1 transcription factors activity. pyrrolidine dithiocarbamic acid 0-27 interleukin 6 Homo sapiens 55-68 9059850-7 1997 However, tumor necrosis factor alpha, interleukin-1 beta, interleukin-6, and NMA each completely blocked the positive chronotropic effects of the beta-adrenoceptor agonist, isoproterenol (P < 0.01; n = 12 for each). Isoproterenol 173-186 interleukin 6 Homo sapiens 58-71 9547608-3 1997 In this study, we have examined the effects of polyunsaturated fatty acids (PUFAs) on the production of IL-6 by human unstimulated EC or EC stimulated with TNF-alpha (100 U/ml); IL-4 (100 U/ml); LPS (1 ug/ml); or allogeneic peripheral blood lymphocytes (PBL). Fatty Acids, Unsaturated 47-74 interleukin 6 Homo sapiens 104-108 9547608-3 1997 In this study, we have examined the effects of polyunsaturated fatty acids (PUFAs) on the production of IL-6 by human unstimulated EC or EC stimulated with TNF-alpha (100 U/ml); IL-4 (100 U/ml); LPS (1 ug/ml); or allogeneic peripheral blood lymphocytes (PBL). Fatty Acids, Unsaturated 76-81 interleukin 6 Homo sapiens 104-108 8968107-9 1996 Exogenous IL-10, IL-6, IL-2, and TNF-alpha significantly enhanced the [3H]thymidine uptake in 13 of 13 (100%), 5 of 13 (38%), 9 of 13 (69%), and 2 of 10 (20%) PTCPs costimulated with anti-CD40, respectively. Thymidine 74-83 interleukin 6 Homo sapiens 17-21 18949559-4 2009 We are developing a cytokine adsorption device (CAD) containing microporous polymer beads that will be used to decrease circulating levels of IL-6, TNF, and IL-10. Polymers 76-83 interleukin 6 Homo sapiens 142-146 8968107-10 1996 IL-2, IL-6, and TNF-alpha synergized with IL-10 in 54, 23, and 30% of PTCPs. ptcps 70-75 interleukin 6 Homo sapiens 6-10 8968107-11 1996 The combination of IL-10, IL-2, and IL-6 induced the maximal level of proliferation in 12 (92%) of 13 PTCPs. ptcps 102-107 interleukin 6 Homo sapiens 36-40 8651752-1 1996 OBJECTIVE: The authors studied the effects of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) on glutamine and alanine transport in isolated human hepatocytes. Glutamine 114-123 interleukin 6 Homo sapiens 46-59 8900430-7 1996 BH101 produced large amounts of IL-1beta, IL-6 and IL-8. bh101 0-5 interleukin 6 Homo sapiens 42-46 19575332-6 2009 In pSS patients, a significant negative correlation was detected between serum levels of IL-6 and the PCS of the SF-36. pss 3-6 interleukin 6 Homo sapiens 89-93 8843914-4 1996 METHODS: In situ hybridization (ISH) using digoxigenin (DIG)-labeled RNA probes was used to localize mRNA for IL-6 and TNF alpha in cultured retinal glial cells. Digoxigenin 43-54 interleukin 6 Homo sapiens 110-114 8843914-4 1996 METHODS: In situ hybridization (ISH) using digoxigenin (DIG)-labeled RNA probes was used to localize mRNA for IL-6 and TNF alpha in cultured retinal glial cells. Digoxigenin 56-59 interleukin 6 Homo sapiens 110-114 8651752-1 1996 OBJECTIVE: The authors studied the effects of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) on glutamine and alanine transport in isolated human hepatocytes. Glutamine 114-123 interleukin 6 Homo sapiens 61-65 8651752-6 1996 Interleukin-6 and TNF-alpha, in combination with the synthetic glucocorticoid dexamethasone, were added to hepatocytes in culture, and the transport of radiolabeled glutamine and alanine was measured. Glutamine 165-174 interleukin 6 Homo sapiens 0-13 8640863-5 1996 At this concentration, okadaic acid suppressed the IL-6-induced IL-6 gene expression of myeloma cells. Okadaic Acid 23-35 interleukin 6 Homo sapiens 51-55 8640863-5 1996 At this concentration, okadaic acid suppressed the IL-6-induced IL-6 gene expression of myeloma cells. Okadaic Acid 23-35 interleukin 6 Homo sapiens 64-68 8640863-6 1996 It seems that the okadaic acid blocked the myeloma cell proliferation by reducing IL-6 synthesis in myeloma cells. Okadaic Acid 18-30 interleukin 6 Homo sapiens 82-86 8640863-9 1996 Interestingly, the presence of okadaic acid induced the up-regulation of IL-6 receptor expression as well as the down-regulation of IL-6-induced gp130 phosphorylation in the myeloma cells. Okadaic Acid 31-43 interleukin 6 Homo sapiens 73-77 8964084-6 1996 2",3"-Dideoxyadenosine, which inhibits adenyl cyclase activity, reduced IL-1, IL-6, and IL-10 levels by 29, 15, and 28% respectively. Dideoxyadenosine 0-22 interleukin 6 Homo sapiens 78-82 19077630-9 2008 RESULTS: Intramedullary instrumentation for isolated PAF caused a significant perioperative increase in the concentrations of IL-6 (preoperative: 16 pg/mL +/- 12 pg/mL, 7 hours: 89 pg/mL +/- 15 pg/mL, and 24 hours: 107 pg/mL +/- 27 pg/mL, p < 0.05). Platelet Activating Factor 53-56 interleukin 6 Homo sapiens 126-130 8631918-6 1996 In addition, cAMP analogues as well as vasoactive intestinal peptide and isoproterenol, two neuropeptides that stimulate bone resorption by activating cAMP signal transduction in osteoblasts, also induce interleukin-6 and leukemia inhibitory factor in these cells. Isoproterenol 73-86 interleukin 6 Homo sapiens 204-217 8631918-7 1996 Taken together with our previous results, this study suggests that interleukin-6 is crucial for stimulation of bone resorption not only by parathyroid hormone, but also by parathyroid hormone-related protein, vasoactive intestinal peptide, and beta-adrenergic agonists, like isoproterenol. Isoproterenol 275-288 interleukin 6 Homo sapiens 67-80 8640863-9 1996 Interestingly, the presence of okadaic acid induced the up-regulation of IL-6 receptor expression as well as the down-regulation of IL-6-induced gp130 phosphorylation in the myeloma cells. Okadaic Acid 31-43 interleukin 6 Homo sapiens 132-136 8614289-5 1996 In contrast, a neutralising polyclonal antibody against IL6 significantly stimulated meningioma proliferation and reduced the inhibitory effects of 8-bromo-cAMP. 8-Bromo Cyclic Adenosine Monophosphate 148-160 interleukin 6 Homo sapiens 56-59 7595543-3 1995 Complete to nearly complete inhibition of interleukin-1 beta-induced interleukin-6 production was observed with the flavonoids genistein and quercetin, the bisindole alkaloids staurosporine and K-252a, or the tyrphostin AG879. Genistein 127-136 interleukin 6 Homo sapiens 69-82 7595543-3 1995 Complete to nearly complete inhibition of interleukin-1 beta-induced interleukin-6 production was observed with the flavonoids genistein and quercetin, the bisindole alkaloids staurosporine and K-252a, or the tyrphostin AG879. Staurosporine 176-189 interleukin 6 Homo sapiens 69-82 7595543-3 1995 Complete to nearly complete inhibition of interleukin-1 beta-induced interleukin-6 production was observed with the flavonoids genistein and quercetin, the bisindole alkaloids staurosporine and K-252a, or the tyrphostin AG879. AG-879 220-225 interleukin 6 Homo sapiens 69-82 7595543-6 1995 The phorbol ester 12-O-tetradecanoylphorbol 13-acetate induced interleukin-6 production, and treatment with a combination of this phorbol ester and interleukin-1 produced synergistic stimulation. Phorbol Esters 4-17 interleukin 6 Homo sapiens 63-76 7595543-6 1995 The phorbol ester 12-O-tetradecanoylphorbol 13-acetate induced interleukin-6 production, and treatment with a combination of this phorbol ester and interleukin-1 produced synergistic stimulation. Phorbol Esters 130-143 interleukin 6 Homo sapiens 63-76 7595543-7 1995 Prolonged exposure to phorbol ester eliminated subsequent stimulation by phorbol ester but only partially decreased interleukin-1-induced interleukin-6 and had no effect on the activities of selected inhibitors including calphostin C. We conclude that tyrosine kinase activity is essential for interleukin-1-induced interleukin-6 production in U373 astrocytoma cells and that activity of a phorbol ester-insensitive, atypical protein kinase C isozyme may also be involved. Phorbol Esters 22-35 interleukin 6 Homo sapiens 138-151 7595543-7 1995 Prolonged exposure to phorbol ester eliminated subsequent stimulation by phorbol ester but only partially decreased interleukin-1-induced interleukin-6 and had no effect on the activities of selected inhibitors including calphostin C. We conclude that tyrosine kinase activity is essential for interleukin-1-induced interleukin-6 production in U373 astrocytoma cells and that activity of a phorbol ester-insensitive, atypical protein kinase C isozyme may also be involved. Phorbol Esters 22-35 interleukin 6 Homo sapiens 316-329 7556963-3 1995 To elucidate the expression and localization of IL-6 mRNA in renal tissues of patients with DN, a high-resolution in situ hybridization using digoxigenin-labeled oligonucleotide was performed. Digoxigenin 142-153 interleukin 6 Homo sapiens 48-52 8740341-0 1996 Changes in interleukin-6 concentrations following epilepsy surgery: potential influence on carbamazepine pharmacokinetics. Carbamazepine 91-104 interleukin 6 Homo sapiens 11-24 8651752-8 1996 RESULTS: Both IL-6 and TNF-alpha exerted a small stimulatory effect on alanine and glutamine transport. Glutamine 83-92 interleukin 6 Homo sapiens 14-18 8676260-6 1996 Fibroblasts exhibited a dose-dependent release of interleukin-6 in response to exposure to titanium-aluminum-vanadium particles. titanium-aluminum-vanadium 91-117 interleukin 6 Homo sapiens 50-63 19294859-1 2008 OBJECTIVE: To discussion the effects of Huoxue components of effective drug in treating unstable angina in patients with blood stasis WBC (WBC), C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha). huoxue 40-46 interleukin 6 Homo sapiens 171-184 7497463-3 1995 In this paper, data are summarized revealing the ability of WBH to induce elevated plasma levels of granulocyte-colony stimulating factor (G-CSF), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), and tumor necrosis factor-alpha (TNF-alpha) within hours of WBH. wbh 60-63 interleukin 6 Homo sapiens 179-192 7497463-3 1995 In this paper, data are summarized revealing the ability of WBH to induce elevated plasma levels of granulocyte-colony stimulating factor (G-CSF), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), and tumor necrosis factor-alpha (TNF-alpha) within hours of WBH. wbh 60-63 interleukin 6 Homo sapiens 194-198 8576941-4 1995 Vesnarinone [OPC-8212; 3,4-dihydro-6-(4-(3,4-dimethoxybenzoil)-1-piperazinyl)-2(1H)- quinolinone] at 26 mumol/l significantly suppressed the production of IL-6, granulocyte macrophage colony stimulating factor (GM-CSF) and granulocyte colony stimulating factor (G-CSF) induced by IL-1 beta. 3,4-dihydro-6-(4-(3,4-dimethoxybenzoil)-1-piperazinyl)-2(1h)- quinolinone 23-96 interleukin 6 Homo sapiens 155-159 8576944-2 1995 Two Ca(2+)-channel blockers, Manidipine (Roth et al., 1992) and Verapamil (Walz et al., 1990) have been shown to induce the expression of the gene coding for interleukin-6 (IL-6). Verapamil 64-73 interleukin 6 Homo sapiens 158-171 19034873-9 2008 LY294002, NH4Cl, CAPE, PD098059 and SB202190 all reduced albumin-mediated IL-6 release, but neither PDTC nor MG132 had any effect. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 interleukin 6 Homo sapiens 74-78 8576944-2 1995 Two Ca(2+)-channel blockers, Manidipine (Roth et al., 1992) and Verapamil (Walz et al., 1990) have been shown to induce the expression of the gene coding for interleukin-6 (IL-6). Verapamil 64-73 interleukin 6 Homo sapiens 173-177 7581842-0 1995 Detection of traces of a trisulphide derivative in the preparation of a recombinant truncated interleukin-6 mutein. trisulphide 25-36 interleukin 6 Homo sapiens 94-107 8720196-11 1995 The findings provide further evidence that expression of TNF-alpha, IL-6 and IL-1-RA plays an important role in mediating AmB-related acute toxicity in vivo. Amphotericin B 122-125 interleukin 6 Homo sapiens 68-72 19080430-11 2008 The proliferation and IL-6 and IL-10 secretion of the T cells from SLE patients cultured with LY294002 were inhibited. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 94-102 interleukin 6 Homo sapiens 22-26 7553641-0 1995 Endogenous interleukin 6 is a resistance factor for cis-diamminedichloroplatinum and etoposide-mediated cytotoxicity of human prostate carcinoma cell lines. Etoposide 85-94 interleukin 6 Homo sapiens 11-24 7477764-3 1995 LPS in concentration 1.5 micrograms/ml stimulated PBM to release IL-1 beta or IL-6 into the supernatants. pbm 50-53 interleukin 6 Homo sapiens 78-82 17405870-6 2008 RESULTS: In the HFOV group IL6 levels were significantly higher on day 3 (0.5 (0.2) vs assisted-control ventilation plus VG group 0.1 (0.2) ng/ml) and oxygen dependency was significantly longer (36 (23) vs assisted-control ventilation plus VG group 19 (11) days). hfov 16-20 interleukin 6 Homo sapiens 27-30 8549096-0 1995 The effect of auranofin and sulphasalazine therapy on circulating levels of interleukin 6 in rheumatoid arthritis patients. Auranofin 14-23 interleukin 6 Homo sapiens 76-89 7738356-7 1995 After pretreatment with IL-2, TIMC from OLP patients generated more IL-6 than did peripheral blood mononuclear cells, and IL-4-pretreated TIMC from the patients released larger amounts of IL-2, IL-6, and IL-10. timc 30-34 interleukin 6 Homo sapiens 68-72 18513800-3 2008 At the amino acid level sbIL-6 shares 23-26% identity with mammalian IL-6 sequences and 30-51% identity with other fish IL-6 sequences. sbil 24-28 interleukin 6 Homo sapiens 69-73 7738356-7 1995 After pretreatment with IL-2, TIMC from OLP patients generated more IL-6 than did peripheral blood mononuclear cells, and IL-4-pretreated TIMC from the patients released larger amounts of IL-2, IL-6, and IL-10. timc 138-142 interleukin 6 Homo sapiens 194-198 7544377-7 1995 Furthermore, NiCl2 was found to induce dose-dependency mRNA production and protein secretion of the NF-kappa B-controlled proinflammatory cytokine IL-6. nickel chloride 13-18 interleukin 6 Homo sapiens 147-151 18360309-4 2008 IL-1beta, IL-6 mRNA were closely correlated to PDGF-B mRNA and myeloperoxidase, but inversely to IGF-I mRNA, Pao2/FiO2 and dynamic lung compliance at 6 h. These results indicate that the association of lower PEEP and iNO may be more protective than surfactant on preventing lung injury and facilitating reparation by affecting the expression of proinflammatory cytokines and GFs. fio2 114-118 interleukin 6 Homo sapiens 10-14 7619053-3 1995 Furthermore, IFN-alpha inhibits the ability of IL-6 to induce increases in [3H]thymidine incorporation. Thymidine 79-88 interleukin 6 Homo sapiens 47-51 7590603-8 1995 In the perfusion experiment, 100 ng/ml of IL-6 suppressed LH (100ng/ml)-induced estradiol (E2) secretion but did not influence progesterone (P4) secretion, while IL-2 had no effect on steroid secretion. Luteinizing Hormone 58-60 interleukin 6 Homo sapiens 42-46 7590603-9 1995 Both IL-2 (100ng/ml) and IL-6 (100ng/ml) significantly suppressed LH-induced ovulation (ovulation rate; 8.3 +/- 1.5, mean +/- SE), to 2.2 +/- 1.1 and 3.2 +/- 1.0, respectively. Luteinizing Hormone 66-68 interleukin 6 Homo sapiens 25-29 7744875-4 1995 In good agreement with our structural model, substitutions at Asn-230, His-280, and Asp-281 selectively impaired the capability of shIL-6R alpha to associate with hgp130 both in vitro and on the cell surface, without affecting its affinity for hIL-6. Asparagine 62-65 interleukin 6 Homo sapiens 132-137 7539633-9 1995 CONCLUSION: Supplementation of an enteral diet with arginine, RNA and omega-3 fatty acids can modulate the acute phase reaction as indicated by the reduction in concentrations of TNF-alpha and IL-6 in the group fed the supplemented diet. Fatty Acids, Omega-3 70-89 interleukin 6 Homo sapiens 193-197 7529912-3 1994 In the present study, we examined the role of adenylate cyclase/cyclic 3",5"-adenosine monophosphate (cAMP) pathway in IL-6 release. cyclic 3",5"-adenosine monophosphate 64-100 interleukin 6 Homo sapiens 119-123 7529912-4 1994 Agents which mimicked (dibutyryl cAMP) or stimulated (isoproterenol and forskolin) cAMP formation were found to induce IL-6 release and their effects could be potentiated by 3-isobutyl-1-methylxanthine (IBMX), a phosphodiesterase inhibitor. Isoproterenol 54-67 interleukin 6 Homo sapiens 119-123 7529912-4 1994 Agents which mimicked (dibutyryl cAMP) or stimulated (isoproterenol and forskolin) cAMP formation were found to induce IL-6 release and their effects could be potentiated by 3-isobutyl-1-methylxanthine (IBMX), a phosphodiesterase inhibitor. 1-Methyl-3-isobutylxanthine 174-201 interleukin 6 Homo sapiens 119-123 7529912-4 1994 Agents which mimicked (dibutyryl cAMP) or stimulated (isoproterenol and forskolin) cAMP formation were found to induce IL-6 release and their effects could be potentiated by 3-isobutyl-1-methylxanthine (IBMX), a phosphodiesterase inhibitor. 1-Methyl-3-isobutylxanthine 203-207 interleukin 6 Homo sapiens 119-123 7706747-0 1995 Effect of IL-6 receptor antisense oligodeoxynucleotide on in vitro proliferation of myeloma cells. Oligodeoxyribonucleotides 34-54 interleukin 6 Homo sapiens 10-14 7890061-8 1995 The mean IL-6 mRNA level in levonorgestrel IUD-exposed endometria was lower than that in late secretory menstrual phase of controls but, because of a great individual variation in the control samples, the difference did not reach significance. Levonorgestrel 28-42 interleukin 6 Homo sapiens 9-13 21556582-6 1995 Similar changes in IL-6 and IL-8 mRNA expression were noted when NUGC3 cells were cultured with paraformaldehyde-fixed 3T3 cells or the 3T3 membrane fraction, thereby supporting this notion. paraform 96-112 interleukin 6 Homo sapiens 19-23 7622611-7 1995 Megakaryocytic colony (CFU-Meg) formation from A-T-PMCs in the presence of interleukin-6 (IL-6) + IL-3 + Epo was also increased after antisense oligodeoxynucleotide treatment. Oligodeoxyribonucleotides 144-164 interleukin 6 Homo sapiens 75-88 7622611-7 1995 Megakaryocytic colony (CFU-Meg) formation from A-T-PMCs in the presence of interleukin-6 (IL-6) + IL-3 + Epo was also increased after antisense oligodeoxynucleotide treatment. Oligodeoxyribonucleotides 144-164 interleukin 6 Homo sapiens 90-94 7834629-7 1995 Treatment of Caki-1 cells with anti-IL-6 mAb or anti-IL-6R mAb in combination with cis-diamminedichloroplatinum(II) (CDDP) or mitomycin C overcame their resistance to CDDP or mitomycin C. Mitomycin 126-137 interleukin 6 Homo sapiens 36-40 18598184-10 2008 Quercetin 3"-sulfate, at 25 micromol/mL, inhibited IL-8 and IL-6 production. quercetin 3'-sulfate 0-20 interleukin 6 Homo sapiens 60-64 17950038-9 2008 Rofecoxib significantly decreased regional IL-6 and TNF-alpha level after surgery. rofecoxib 0-9 interleukin 6 Homo sapiens 43-47 7875195-2 1995 We investigated the ability of aAb-IL-6 derived from IVIg to interfere with IL-6 binding to the undifferentiated monocytic cell line U-937. p-Aminoazobenzene 31-34 interleukin 6 Homo sapiens 35-39 7875195-2 1995 We investigated the ability of aAb-IL-6 derived from IVIg to interfere with IL-6 binding to the undifferentiated monocytic cell line U-937. p-Aminoazobenzene 31-34 interleukin 6 Homo sapiens 76-80 7875213-2 1995 This study shows that nonproliferating (hydroxyurea-treated), immunoglobulin (Ig)-secreting cells generated from human B cells in the EL-4 culture system no longer express interleukin (IL)-6 mRNA, progressively lose IL-10 mRNA, but continue to express transforming growth factor (TGF)-beta 1 mRNA. Hydroxyurea 40-51 interleukin 6 Homo sapiens 172-190 7915945-1 1994 IL-6 production by peripheral blood monocytes isolated from RA patients receiving the second-line drugs auranofin (AUR), sulphasalazine (SASP) or gold sodium aurothiomalate (GST) was investigated. Auranofin 104-113 interleukin 6 Homo sapiens 0-4 7915945-1 1994 IL-6 production by peripheral blood monocytes isolated from RA patients receiving the second-line drugs auranofin (AUR), sulphasalazine (SASP) or gold sodium aurothiomalate (GST) was investigated. Auranofin 115-118 interleukin 6 Homo sapiens 0-4 7915945-1 1994 IL-6 production by peripheral blood monocytes isolated from RA patients receiving the second-line drugs auranofin (AUR), sulphasalazine (SASP) or gold sodium aurothiomalate (GST) was investigated. gold sodium aurothiomalate 146-172 interleukin 6 Homo sapiens 0-4 17950038-10 2008 Moreover, the incidence of febris and degree of local edema were lower in the rofecoxib group (P < .05), and peripheral IL-6 level significantly correlated with pain score at 48 hours. rofecoxib 78-87 interleukin 6 Homo sapiens 123-127 7476567-1 1995 Previous findings provided evidence that bacterial lipopolysaccharide (LPS)-activated human monocytes are able to upregulate autologous polymorphonuclear (PMN) phagocytic ability via cell-to-cell contact mechanisms mediated by membrane (m)-associated cytokines (CKs), such as tumour necrosis factor (TNF)-alpha, interleukin (IL)-1 alpha, IL-1 beta, IL-6 and IL-8. bacterial lipopolysaccharide 41-69 interleukin 6 Homo sapiens 349-353 8063416-2 1994 PBMC and Mphi from all these donor groups secreted increased levels of tumor necrosis factor alpha, interleukin-1 beta, and interleukin-6 in response to stimulation with formalin-killed spherules (FKS), as measured by enzyme-linked immunosorbent assays. 7-[(3-Aminopropyl)amino]-1,1,1-Trifluoroheptane-2,2-Diol 197-200 interleukin 6 Homo sapiens 124-137 18958157-10 2008 Moreover, DBT abrogated the glucocorticoid-mediated suppression of interleukin-6 (IL-6) and TNF-alpha production in lipopolysaccharide (LPS)-stimulated native human macrophages and human THP-1 macrophages. di-n-butyltin 10-13 interleukin 6 Homo sapiens 67-80 7831669-3 1994 Dazoxiben (0.2 to 160 microM) pretreated PRP incubated with IL-6 and aggregated with ionophore A23187, showed a dose dependent inhibition of TXB2 secretion concomitant with a dose dependent abrogation of IL-6"s enhancement of AIMA. dazoxiben 0-9 interleukin 6 Homo sapiens 60-64 7831669-3 1994 Dazoxiben (0.2 to 160 microM) pretreated PRP incubated with IL-6 and aggregated with ionophore A23187, showed a dose dependent inhibition of TXB2 secretion concomitant with a dose dependent abrogation of IL-6"s enhancement of AIMA. dazoxiben 0-9 interleukin 6 Homo sapiens 204-208 7516173-7 1994 mRNA analysis demonstrated that these alterations in protein production were associated with proportionate decreases in IL-6 mRNA accumulation, and that this suppression of IL-6 mRNA could be reversed by the glucocorticoid receptor antagonist RU 486. Mifepristone 243-249 interleukin 6 Homo sapiens 120-124 7516173-7 1994 mRNA analysis demonstrated that these alterations in protein production were associated with proportionate decreases in IL-6 mRNA accumulation, and that this suppression of IL-6 mRNA could be reversed by the glucocorticoid receptor antagonist RU 486. Mifepristone 243-249 interleukin 6 Homo sapiens 173-177 7949016-7 1994 IL-6 (10(-2)-10 ng/ml) stimulated the [3H]-thymidine uptake up to 218-303 % of control level, and the percentage of cells in S+G2/M phase was increased in IL-6-treated normal thyroid cells as compared to EGF-treated cells. Thymidine 43-52 interleukin 6 Homo sapiens 0-4 7949016-1 1994 To investigate the role of interleukins on the growth of human thyroid cells, the effect of IL-2, IL-4 and IL-6 was studied on EGF-induced [3H]-thymidine uptake, cell cycle by flow cytometry, and mRNA levels of cellular proto-oncogene c-fos in thyroid monolayer cells from eighteen patients with Graves" disease and sixteen with non-thyroidal disease. Thymidine 144-153 interleukin 6 Homo sapiens 107-111 7515809-3 1994 Herbimycin A and genistein, inhibitors of tyrosine kinases, markedly attenuated LPS-induced tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) protein and mRNA production. Genistein 17-26 interleukin 6 Homo sapiens 136-149 7515809-3 1994 Herbimycin A and genistein, inhibitors of tyrosine kinases, markedly attenuated LPS-induced tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) protein and mRNA production. Genistein 17-26 interleukin 6 Homo sapiens 151-155 8283061-4 1994 When KS cells were incubated with poly (I:C) in combination with either IL-1 beta or TNF-alpha, there was a synergistic increase in the level of IL-6 production, whereas LPS and TNF-alpha in combination led to only an additive increase in the level of IL-6 production. poly 34-38 interleukin 6 Homo sapiens 145-149 8283061-4 1994 When KS cells were incubated with poly (I:C) in combination with either IL-1 beta or TNF-alpha, there was a synergistic increase in the level of IL-6 production, whereas LPS and TNF-alpha in combination led to only an additive increase in the level of IL-6 production. poly 34-38 interleukin 6 Homo sapiens 252-256 8283061-7 1994 Pretreatment of KS cells with poly (I:C) for 24 h followed by removal of the poly (I:C) led to high levels of IL-6 secreted into medium that induced proliferation in KS cells. poly 30-34 interleukin 6 Homo sapiens 110-114 18958157-10 2008 Moreover, DBT abrogated the glucocorticoid-mediated suppression of interleukin-6 (IL-6) and TNF-alpha production in lipopolysaccharide (LPS)-stimulated native human macrophages and human THP-1 macrophages. di-n-butyltin 10-13 interleukin 6 Homo sapiens 82-86 8195701-7 1994 The effects of isoprenoid depletion on cytokine production were selective: IL-1 beta generation was not inhibited but the production of IL-6 and IL-8 was concomitantly suppressed. Terpenes 15-25 interleukin 6 Homo sapiens 136-140 18087545-0 2007 [Isoproterenol regulates lipopolysaccharide-induced tumor necrosis factor-alpha and interleukin-6 production in monocytes from essential hypertensive patients.]. Isoproterenol 1-14 interleukin 6 Homo sapiens 84-97 8301142-9 1994 13-cis-retinoic acid, retinol, retinaldehyde, all-trans etretin, Ro 13-6298, and 9-cis retinoic acid also inhibited IL-1-induced IL-6 production. Vitamin A 22-29 interleukin 6 Homo sapiens 129-133 8258685-8 1993 In addition to cytokine mRNA levels, LPS-induced IL-6 protein synthesis and IL-6 bioactivity were also reduced to baseline levels by the PTK inhibitors herbimycin A and genistein. Genistein 169-178 interleukin 6 Homo sapiens 49-53 8260708-10 1993 Paraformaldehyde fixation of BMSCs before adhesion completely abrogated IL-6 secretion, suggesting that IL-6 secretion was triggered in BMSCs rather than in cell lines. paraform 0-16 interleukin 6 Homo sapiens 72-76 8260708-10 1993 Paraformaldehyde fixation of BMSCs before adhesion completely abrogated IL-6 secretion, suggesting that IL-6 secretion was triggered in BMSCs rather than in cell lines. paraform 0-16 interleukin 6 Homo sapiens 104-108 8403558-8 1993 The EC50 of LPS-induced IL-6 production by HC was 2.0 x 10(-7) M. The inhibitory effect of HC on LPS-stimulated IL-6 production was GC specific and receptor mediated because: (i) equivalent inhibition was not observed with other endogenous steroids and (ii) equimolar amounts of the GC antagonist RU 486 blocked the GC-mediated effect. Mifepristone 297-303 interleukin 6 Homo sapiens 24-28 8403558-8 1993 The EC50 of LPS-induced IL-6 production by HC was 2.0 x 10(-7) M. The inhibitory effect of HC on LPS-stimulated IL-6 production was GC specific and receptor mediated because: (i) equivalent inhibition was not observed with other endogenous steroids and (ii) equimolar amounts of the GC antagonist RU 486 blocked the GC-mediated effect. Mifepristone 297-303 interleukin 6 Homo sapiens 112-116 8258685-8 1993 In addition to cytokine mRNA levels, LPS-induced IL-6 protein synthesis and IL-6 bioactivity were also reduced to baseline levels by the PTK inhibitors herbimycin A and genistein. Genistein 169-178 interleukin 6 Homo sapiens 76-80 18210237-7 2007 Pre-incubation with costunolide inhibited LPS-induced production of TNF-alpha and IL-6. costunolide 20-31 interleukin 6 Homo sapiens 82-86 8354288-2 1993 Degradation of 125I-IL-6 by plasma membranes was completely prevented by the serine-protease inhibitor diisopropyl fluorophosphate, but was only partially impaired by alpha 1-protease inhibitor and antibody against cathepsin G. A similar incubation of 125I-IL-6 with cathepsin G purified from U937 cells caused hydrolysis of the cytokine into similar inactive 8-kDa fragments, whereas incubation with purified U937 cell elastase failed to degrade the peptide. Isoflurophate 103-130 interleukin 6 Homo sapiens 20-24 8275059-0 1993 Peptidoglycan and teichoic acid from Staphylococcus epidermidis stimulate human monocytes to release tumour necrosis factor-alpha, interleukin-1 beta and interleukin-6. Teichoic Acids 18-31 interleukin 6 Homo sapiens 154-167 18210237-8 2007 The inhibitory effects of costunolide on TNF-alpha and IL-6 production were abrogated by tin protoporphyrin, an HO inhibitor. costunolide 26-37 interleukin 6 Homo sapiens 55-59 8275059-5 1993 Peptidoglycan and teichoic acid induced TNF, IL-1, and IL-6 in a concentration-dependent manner. Teichoic Acids 18-31 interleukin 6 Homo sapiens 55-59 17891168-7 2007 The H(1) receptor antagonist, mepyramine, caused a rightward shift in the concentration-response curves of TNFalpha-induced NF-kappaB-dependent transcription (pA(2)=9.91) and release of IL-6 (pA(2)=8.78) and IL-8 (pA(2)=8.99). Pyrilamine 30-40 interleukin 6 Homo sapiens 186-190 17581928-6 2007 In addition, genistein and herbimycin A completely blocked the IL-6-induced increases in alpha-MG uptake and the protein expression level of SGLTs. Genistein 13-22 interleukin 6 Homo sapiens 63-67 8239612-0 1993 Preincubation of Candida albicans strains with amphotericin B reduces tumor necrosis factor alpha and interleukin-6 release by human monocytes. Amphotericin B 47-61 interleukin 6 Homo sapiens 102-115 7693792-3 1993 Genistein, a tyrosine kinase inhibitor inhibited the interleukin 6 stimulated synthesis of acute phase proteins suggesting that a tyrosine kinase event participates in the signal transduction pathway. Genistein 0-9 interleukin 6 Homo sapiens 53-66 17581928-9 2007 A pretreatment with STAT3 inhibitor LY 294002, an Akt inhibitor, or MAPK inhibitors significantly blocked the IL-6-induced increase in alpha-MG uptake. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 36-45 interleukin 6 Homo sapiens 110-114 8393337-1 1993 It has been demonstrated that reductive 17 beta-hydroxysteroid dehydrogenase activity (17-HSD) in the human breast cancer cell line MCF-7 can be stimulated by 17 beta-estradiol (E2), progesterone (P) and interleukin-6 (IL-6). 17-hsd 87-93 interleukin 6 Homo sapiens 204-217 8393337-1 1993 It has been demonstrated that reductive 17 beta-hydroxysteroid dehydrogenase activity (17-HSD) in the human breast cancer cell line MCF-7 can be stimulated by 17 beta-estradiol (E2), progesterone (P) and interleukin-6 (IL-6). 17-hsd 87-93 interleukin 6 Homo sapiens 219-223 8482564-4 1993 Exposure of ovarian cancer cell lines (CAOV-3, OVCAR-3, and OC-436), to 1-5 microM of a 15-base single-stranded antisense IL-6 oligodeoxynucleotide, specific for a sequence in the second coding exon of the IL-6 gene, resulted in decreased IL-6 production and a > 80-85% inhibition of cellular proliferation. Oligodeoxyribonucleotides 127-147 interleukin 6 Homo sapiens 122-126 8370693-6 1993 The addition of genistein to rIL-1- and rTNF-alpha-stimulated trophoblasts inhibited rIL-1-induced and rTNF-alpha induced hCG production but maintained rIL-1- and rTNF-alpha-induced IL-6 production. Genistein 16-25 interleukin 6 Homo sapiens 182-186 17446059-6 2007 EGCG significantly inhibited the IL-1beta+Abeta (25-35)-induced IL-6, IL-8, vascular endothelial growth factor (VEGF) and prostaglandin (PG)E(2) production at 24 h (P<.01). epigallocatechin gallate 0-4 interleukin 6 Homo sapiens 64-68 8245177-2 1993 Furthermore, in monocytes, protein kinase C (PKC) activation by PMA even reduced IL-1-induced IL-6 mRNA, and IL-1-induced IL-6 synthesis was increased by the PKC inhibitor staurosporine. Staurosporine 172-185 interleukin 6 Homo sapiens 94-98 8245177-2 1993 Furthermore, in monocytes, protein kinase C (PKC) activation by PMA even reduced IL-1-induced IL-6 mRNA, and IL-1-induced IL-6 synthesis was increased by the PKC inhibitor staurosporine. Staurosporine 172-185 interleukin 6 Homo sapiens 122-126 7681633-6 1993 These effects were dose dependent with a concentration of 2 x 10(-9) M PGE1, 5 x 10(-6) M forskolin, 5 x 10(-4) M DBcAMP, and 1 x 10(-3) M IBMX decreasing rIL-1 alpha (2.5 ng/ml)-induced IL-6 production by approximately 50%. 1-Methyl-3-isobutylxanthine 139-143 interleukin 6 Homo sapiens 187-191 7683888-2 1993 Incorporation of labelled thymidine was significantly decreased by IL-6, IL-1 and HGF but only slightly by LIF and RA. Thymidine 26-35 interleukin 6 Homo sapiens 67-71 17446059-7 2007 The maximal inhibition rate of IL-6, IL-8, VEGF and PGE(2) production by EGCG was approximately 54.40%, 56.01%, 69.06% and 47.03%, respectively. epigallocatechin gallate 73-77 interleukin 6 Homo sapiens 31-35 17569825-4 2007 We identified the vitamin A metabolite retinoic acid as a key regulator of TGF-beta-dependent immune responses, capable of inhibiting the IL-6-driven induction of proinflammatory T(H)17 cells and promoting anti-inflammatory Treg cell differentiation. Vitamin A 18-27 interleukin 6 Homo sapiens 138-142 8505858-2 1993 In the present study, we found that R-phenylisopropyladenosine (R-PIA), 5"-N-ethylcarboxamido adenosine (NECA), other agonists of adenosine receptors and dipyridamole, an adenosine uptake inhibitor, inhibited tumor necrosis factor (TNF) production by endotoxin-stimulated human monocytes in a concentration-dependent manner with no inhibition of interleukin-6. Dipyridamole 154-166 interleukin 6 Homo sapiens 346-359 8314823-6 1993 Exposure to titanium-aluminum-vanadium increased the release of prostaglandin E2, interleukin-1, tumor necrosis factor, and interleukin-6. titanium-aluminum-vanadium 12-38 interleukin 6 Homo sapiens 124-137 8314823-7 1993 In contrast, exposure to cobalt-chromium particles was associated with a decreased release of prostaglandin E2 and interleukin-6, and it had little effect on the release of interleukin-1 and tumor necrosis factor. Cobalt 25-31 interleukin 6 Homo sapiens 115-128 17608808-4 2007 The release of interleukin-1beta and interleukin-6, nuclear translocation of NF-kappaB and its DNA binding activity in the SEC1-stimulated PBMC were time-dependent and were completely eliminated by pyrrolidine dithiocarbamate or SN-50 (NF-kappaB inhibitors). pyrrolidine dithiocarbamic acid 198-225 interleukin 6 Homo sapiens 37-50 7679006-3 1993 However, in the presence of optimal concentrations of granulocyte colony-stimulating factor (G-CSF) or interleukin-6 (IL-6), TPA or bryostatin markedly elevated the number of colonies formed from the GM-CFC. Bryostatins 132-142 interleukin 6 Homo sapiens 103-116 7679006-3 1993 However, in the presence of optimal concentrations of granulocyte colony-stimulating factor (G-CSF) or interleukin-6 (IL-6), TPA or bryostatin markedly elevated the number of colonies formed from the GM-CFC. Bryostatins 132-142 interleukin 6 Homo sapiens 118-122 1634815-5 1992 There was a highly symmetrical correlation between IL-6 and the percentage of polymorphonuclear cells in CSF of patients with PBM (r = .97, P = .01) and AM (r = .49, P = .002). pbm 126-129 interleukin 6 Homo sapiens 51-55 1496542-1 1992 We studied the effect of cyclosporine A, prednisolone, and the Ca2+ channel blocker verapamil on interleukin-6 binding to mitogen-activated peripheral blood mononuclear cells, using a flow cytometric technique and phycoerythrin-conjugated IL-6. Verapamil 84-93 interleukin 6 Homo sapiens 97-110 17504508-9 2007 Monocytes of patients with CARD15 polymorphisms showed an early reduced cytokine response (IL-1beta, IL-6 and IL-10) to infection with AIEC, which was restored after 20 h. A gene-dose effect was seen, comparing wild-types, heterozygotes and homozygotes. aiec 135-139 interleukin 6 Homo sapiens 101-105 1321818-10 1992 Furthermore, the region between residues Ser178 and Arg183 (Ser-Leu-Arg-Ala-X-Arg) is identified as a receptor binding site in the COOH terminus of human IL-6. ala-x-arg 72-81 interleukin 6 Homo sapiens 154-158 1377908-0 1992 Okadaic acid, an inhibitor of protein phosphatases 1 and 2A, inhibits induction of acute-phase proteins by interleukin-6 alone or in combination with interleukin-1 in human hepatoma cell lines. Okadaic Acid 0-12 interleukin 6 Homo sapiens 107-120 1465772-3 1992 Irradiated or mitomycin-c treated PBMC could easily be induced (with LPS) to produce IL-6 and IL-1 while no activity was measured after 48 hr in the supernatant of PHA-stimulated T cells, suggesting that in the MLC the monokines were entirely produced by stimulator PBMC. Mitomycin 14-25 interleukin 6 Homo sapiens 85-89 1429735-7 1992 Retinol reduced the interleukin 6 production induced by anti-IgM and interleukin 4 after 48 h, whereas the induction of interleukin 6 and tumor necrosis factor by O-tetradecanoylphorbol-13-acetate and ionomycin was less affected. Vitamin A 0-7 interleukin 6 Homo sapiens 20-33 1377908-1 1992 Okadaic acid (OA), a specific inhibitor of protein phosphatases 1 and 2A, inhibited in a dose-dependent manner (5-20 nM) the induction of C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen by interleukin-6 (IL-6) plus interleukin-1 (IL-1), and of fibrinogen by IL-6 alone, in Hep 3B cells. Okadaic Acid 0-12 interleukin 6 Homo sapiens 204-217 17395587-6 2007 The induction of IL-6 by salmeterol was dependent upon the beta(2) receptor and could also be induced by cAMP or cAMP-elevating agents forskolin and rolipram. Rolipram 149-157 interleukin 6 Homo sapiens 17-21 1377908-1 1992 Okadaic acid (OA), a specific inhibitor of protein phosphatases 1 and 2A, inhibited in a dose-dependent manner (5-20 nM) the induction of C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen by interleukin-6 (IL-6) plus interleukin-1 (IL-1), and of fibrinogen by IL-6 alone, in Hep 3B cells. Okadaic Acid 0-12 interleukin 6 Homo sapiens 219-223 1377908-1 1992 Okadaic acid (OA), a specific inhibitor of protein phosphatases 1 and 2A, inhibited in a dose-dependent manner (5-20 nM) the induction of C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen by interleukin-6 (IL-6) plus interleukin-1 (IL-1), and of fibrinogen by IL-6 alone, in Hep 3B cells. Okadaic Acid 0-12 interleukin 6 Homo sapiens 273-277 1506211-6 1992 In cell culture studies it has been shown that macrophages/monocytes release IL1, IL6 and TNF after ingestion of silica, which affects fibroblasts, T-helper cells and endothelial cells. Silicon Dioxide 113-119 interleukin 6 Homo sapiens 82-85 17360175-2 2007 In this paper, a sensitive fluoroimmunoassay for recombinant human interleukin-6 (IL-6) with the functionalized Rubpy-encapsulated fluorescent core-shell silica nanoparticles labeling technique has been proposed. Silicon Dioxide 154-160 interleukin 6 Homo sapiens 67-80 1405316-6 1992 Compared to IL-6 synthesis in control subjects (6.0 +/- 5.6 U/3 x 10(6) PBMC/24 hr), hemodialyzed patients, when treated with cuprophan membranes, showed significantly higher value of IL-6 production both before (23 +/- 13 U/3 x 10(6) PBMC/24 hr) and after (26.2 +/- 11.3 U/3 x 10(6) PBMC/24 hr) the dialytic session. cuprammonium cellulose 126-135 interleukin 6 Homo sapiens 12-16 1405316-6 1992 Compared to IL-6 synthesis in control subjects (6.0 +/- 5.6 U/3 x 10(6) PBMC/24 hr), hemodialyzed patients, when treated with cuprophan membranes, showed significantly higher value of IL-6 production both before (23 +/- 13 U/3 x 10(6) PBMC/24 hr) and after (26.2 +/- 11.3 U/3 x 10(6) PBMC/24 hr) the dialytic session. cuprammonium cellulose 126-135 interleukin 6 Homo sapiens 184-188 1607370-2 1992 Monocytes/macrophages incubated on biomedical polymers with or without protein preadsorption produce variable levels of IL-1-B, IL-6, and TNF-A dependent on the polymer and adsorbed protein. Polymers 46-54 interleukin 6 Homo sapiens 128-132 1370482-5 1992 Like TNF, okadaic acid also induces the transcription of immediate early response genes like c-jun and Egr-1 as well as the interleukin-6 genes. Okadaic Acid 10-22 interleukin 6 Homo sapiens 124-137 1389011-1 1992 We investigated the capacity of cellulose cuprophane (CUP) and synthetic polyacrylonitrile dialysis membranes to induce the production of interleukin 1 (IL-1), interleukin 6 (IL-6), and tumor necrosis factor alpha using an in vitro model in which normal whole blood is incubated directly with calibrated membrane fragments. cellulose cuprophane 32-52 interleukin 6 Homo sapiens 160-173 1389011-1 1992 We investigated the capacity of cellulose cuprophane (CUP) and synthetic polyacrylonitrile dialysis membranes to induce the production of interleukin 1 (IL-1), interleukin 6 (IL-6), and tumor necrosis factor alpha using an in vitro model in which normal whole blood is incubated directly with calibrated membrane fragments. cellulose cuprophane 32-52 interleukin 6 Homo sapiens 175-179 1937825-2 1991 Lipopolysaccharide of Salmonella abortus equi and synthetic Escherichia coli-type lipid A (compound 506, or LA-15-PP) had potent interleukin-6-inducing capacities. la-15-pp 108-116 interleukin 6 Homo sapiens 129-142 1377908-1 1992 Okadaic acid (OA), a specific inhibitor of protein phosphatases 1 and 2A, inhibited in a dose-dependent manner (5-20 nM) the induction of C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen by interleukin-6 (IL-6) plus interleukin-1 (IL-1), and of fibrinogen by IL-6 alone, in Hep 3B cells. Okadaic Acid 14-16 interleukin 6 Homo sapiens 204-217 1377908-1 1992 Okadaic acid (OA), a specific inhibitor of protein phosphatases 1 and 2A, inhibited in a dose-dependent manner (5-20 nM) the induction of C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen by interleukin-6 (IL-6) plus interleukin-1 (IL-1), and of fibrinogen by IL-6 alone, in Hep 3B cells. Okadaic Acid 14-16 interleukin 6 Homo sapiens 219-223 17360175-2 2007 In this paper, a sensitive fluoroimmunoassay for recombinant human interleukin-6 (IL-6) with the functionalized Rubpy-encapsulated fluorescent core-shell silica nanoparticles labeling technique has been proposed. Silicon Dioxide 154-160 interleukin 6 Homo sapiens 82-86 1377908-1 1992 Okadaic acid (OA), a specific inhibitor of protein phosphatases 1 and 2A, inhibited in a dose-dependent manner (5-20 nM) the induction of C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen by interleukin-6 (IL-6) plus interleukin-1 (IL-1), and of fibrinogen by IL-6 alone, in Hep 3B cells. Okadaic Acid 14-16 interleukin 6 Homo sapiens 273-277 1680274-4 1991 Using H1 receptor (cetirizin and loderix) and H2 receptor (cimetidine and ranitidine) specific antagonists, an H1-dependent stimulation of IL-6 binding by CESS cells was found. setastine 33-40 interleukin 6 Homo sapiens 139-143 17613244-2 2007 The objective of this study was to determine the effect of an isocaloric diet supplemented with a plant-based dietary omega-3 fatty acid [alpha-linolenic acid (ALA)] on interleukin-6, C-reactive protein, serum amyloid A, and tumor necrosis factor-alpha. Fatty Acids, Omega-3 118-136 interleukin 6 Homo sapiens 169-182 2011918-7 1991 Interleukin 6 also inhibited 8-bromo-cyclic adenosine monophosphate-induced thyroid peroxidase mRNA levels. 8-Bromo Cyclic Adenosine Monophosphate 29-67 interleukin 6 Homo sapiens 0-13 1544169-4 1992 The IL6 production by T cells required the presence of either fresh or paraformaldehyde-fixed monocytes. paraform 71-87 interleukin 6 Homo sapiens 4-7 17593869-4 2007 The IL-6/IL-10 ratio significantly increased with propofol compared with isoflurane on day 1 after surgery and the IL-10 level significantly increased with isoflurane on day 1 after surgery. Isoflurane 73-83 interleukin 6 Homo sapiens 4-8 1577464-5 1992 The addition of interleukin-6 (IL-6) to an unconditioned culture medium increased the resistance of FA cells to MMC cytotoxicity. Mitomycin 112-115 interleukin 6 Homo sapiens 16-29 1577464-5 1992 The addition of interleukin-6 (IL-6) to an unconditioned culture medium increased the resistance of FA cells to MMC cytotoxicity. Mitomycin 112-115 interleukin 6 Homo sapiens 31-35 1572702-0 1992 The role of interleukin-6 in vitamin A deficiency during Plasmodium falciparum malaria and possible consequences for vitamin A supplementation. Vitamin A 29-38 interleukin 6 Homo sapiens 12-25 1572702-2 1992 It was found that IL-6 levels followed the rise and decrease of parasitaemia by 12 hr and correlated inversely with levels of vitamin A and its binding proteins. Vitamin A 126-135 interleukin 6 Homo sapiens 18-22 1806185-3 1991 For instance, we showed that oligodeoxynucleotides antisens of IL6 mRNA were capable to decrease the proliferation of two different myeloma cell lines. Oligodeoxyribonucleotides 29-50 interleukin 6 Homo sapiens 63-66 1866079-5 1991 Compared to Il-6 synthesis in control subjects (3.3 +/- 2.8 U/ml) the patients usually haemodialysed with cuprophane membranes showed significantly greater values (9.8 +/- 4.5 U/ml, P less than 0.02 before the treatment, and 10.4 +/- 6.1 U/ml, P less than 0.05 after the treatment). cuprammonium cellulose 106-116 interleukin 6 Homo sapiens 12-16 17374166-3 2007 Statins and Bisphosphonates inhibit Interleukin 6 mediated inflammation indirectly through regulation of endogenous cholesterol synthesis and isoprenoid depletion. Terpenes 142-152 interleukin 6 Homo sapiens 36-49 1866079-7 1991 In conclusion, our results show increased Il-6 production in haemodialysed patients usually treated with cuprophane membranes, suggesting a chronic stimulation. cuprammonium cellulose 105-115 interleukin 6 Homo sapiens 42-46 1385054-1 1992 The interleukin 6 (IL-6) promoter is rapidly and transiently activated by other cytokines, including IL-1 and tumour necrosis factor (TNF), as well as by phorbol esters and cyclic AMP agonists. Phorbol Esters 154-168 interleukin 6 Homo sapiens 4-17 1385054-1 1992 The interleukin 6 (IL-6) promoter is rapidly and transiently activated by other cytokines, including IL-1 and tumour necrosis factor (TNF), as well as by phorbol esters and cyclic AMP agonists. Phorbol Esters 154-168 interleukin 6 Homo sapiens 19-23 1577093-3 1992 IL-6 was measured by a [3H] thymidine incorporation assay using the IL-6-dependent B9 cell line; 1 U is approximately equal to 1 pg/ml of a recombinant (r)IL-6 standard. Thymidine 28-37 interleukin 6 Homo sapiens 0-4 17133451-7 2007 However, silica-ceramic suppressed the synthesis of cytokines involved in inflammation, in particular, the expression of IL-1beta and IL-6 was reduced at the transcriptional and translational levels. Silicon Dioxide 9-15 interleukin 6 Homo sapiens 134-138 1940549-4 1991 IL-6, TGF-beta 1 and decidual supernatants stimulated both hPL, hCG production and 3H-thymidine uptake, especially TGF-beta 1 and decidual supernatants. Thymidine 86-95 interleukin 6 Homo sapiens 0-4 1893956-7 1991 These results demonstrate that the survival of human marrow CFU-GM and BFU-E can be influenced by IL-1, IL-6, LF, and T-lymphocytes. 1-(5-bromo-pyridin-2-yl)-3-[2-(6-fluoro-2-hydroxy-3-propionyl-phenyl)-cyclopropyl]-urea 71-74 interleukin 6 Homo sapiens 104-108 1721559-5 1991 This stimulatory effect of kE on the binding of iE to HSF could be inhibited by neomycin, retinal and pertussis toxin, substances which act at different levels of the transduction mechanism following the activation of the receptor and the subsequent triggering of cell biological events (chemotaxis, modification of calcium fluxes). Neomycin 80-88 interleukin 6 Homo sapiens 54-57 1818294-3 1991 For instance, we showed that oligodeoxynucleotides antisens of IL6 mRNA were capable to decrease the proliferation of two different myeloma cell lines. Oligodeoxyribonucleotides 29-50 interleukin 6 Homo sapiens 63-66 1924432-8 1991 In line with the effects of PMA, staurosporin induced IL-6 production in monocytes and it inhibited IL-1 driven IL-6 production by endothelial cells. Staurosporine 33-45 interleukin 6 Homo sapiens 54-58 1924432-8 1991 In line with the effects of PMA, staurosporin induced IL-6 production in monocytes and it inhibited IL-1 driven IL-6 production by endothelial cells. Staurosporine 33-45 interleukin 6 Homo sapiens 112-116 17310430-3 2007 HUVECs were also exposed to Escherichia coli lipopolysaccaride (LPS) as an in vitro model of inflammation: significant IL-6 release was measured. lipopolysaccaride 45-62 interleukin 6 Homo sapiens 119-123 2208301-3 1990 In the present study, we investigated the requirement of interleukin 6 (IL-6) for the "spontaneous" in vitro production of IgG-Tet by LB B cells. tetramethylenedisulfotetramine 127-130 interleukin 6 Homo sapiens 57-70 2208301-3 1990 In the present study, we investigated the requirement of interleukin 6 (IL-6) for the "spontaneous" in vitro production of IgG-Tet by LB B cells. tetramethylenedisulfotetramine 127-130 interleukin 6 Homo sapiens 72-76 2050135-3 1991 Upon cell induction with isopropyl thiogalactopyranoside, recombinant human interleukin-6 is overexpressed and forms insoluble inclusion bodies. SCHEMBL55083 25-56 interleukin 6 Homo sapiens 76-89 2045425-2 1991 Experiments with an adenocarcinoma-derived cell line (HeLa) reveal that activation of the transfected human IL-6 promoter occurs largely through two partially overlapping second messenger (cAMP, phorbol ester)- and cytokine (IL-1, TNF, serum)-responsive enhancer elements (MRE 1, -173 to -151 and MRE II, -158 to -145). Phorbol Esters 195-208 interleukin 6 Homo sapiens 108-112 1775252-6 1991 We also found that Cuprophan induced a reversible decrease of spontaneous and LPS-stimulated production of TNF, IL1 and IL6 during the haemodialysis session. cuprammonium cellulose 19-28 interleukin 6 Homo sapiens 120-123 1775266-5 1991 In comparison to polystyrole (724 +/- 34 pg/ml), IL-6 production by PBMC was significantly reduced in the presence of Cuprophan (151 +/- 45 pg/ml), Hemophan (167 +/- 6 pg/ml) and polyacrylonitrile (108 +/- 33 pg/ml). cuprammonium cellulose 118-127 interleukin 6 Homo sapiens 49-53 1700730-7 1990 Increase of 3H-thymidine incorporation by megakaryoblasts could be duplicated by exogenous IL-6 that could be blocked by neutralizing MoAb to IL-6. Thymidine 15-24 interleukin 6 Homo sapiens 91-95 2208301-5 1990 However, addition of anti-IL-6 antibodies decreased IgG-Tet production as much as 70%, and this inhibition could be reversed by the addition of IL-6. tetramethylenedisulfotetramine 56-59 interleukin 6 Homo sapiens 26-30 2208301-5 1990 However, addition of anti-IL-6 antibodies decreased IgG-Tet production as much as 70%, and this inhibition could be reversed by the addition of IL-6. tetramethylenedisulfotetramine 56-59 interleukin 6 Homo sapiens 144-148 1700730-7 1990 Increase of 3H-thymidine incorporation by megakaryoblasts could be duplicated by exogenous IL-6 that could be blocked by neutralizing MoAb to IL-6. Thymidine 15-24 interleukin 6 Homo sapiens 142-146 2208301-7 1990 Addition of 2.5 units/ml of IL-6 to serum-free cultures induced an increase in IgG-Tet secretion nearly comparable to that seen in cultures supplied with serum. tetramethylenedisulfotetramine 83-86 interleukin 6 Homo sapiens 28-32 17432674-9 2007 CONCLUSION: DXP is effective in improving symptoms of depression by regulating the levels of 5-HT, BDNF, CORT and IL-6. dxp 12-15 interleukin 6 Homo sapiens 114-118 2129417-3 1990 Keratinocyte-growth was increased by stimulation with recombinant IL 6 (as measured by either [3H] thymidine uptake or direct cell count). Thymidine 99-108 interleukin 6 Homo sapiens 66-70 2111442-1 1990 The interleukin-6 (IL-6) promoter is rapidly and transiently activated with other cytokines, including IL-1, tumor necrosis factor, and platelet-derived growth factor, as well as phorbol esters and agents that increase intracellular cyclic AMP. Phorbol Esters 179-193 interleukin 6 Homo sapiens 4-17 2111442-1 1990 The interleukin-6 (IL-6) promoter is rapidly and transiently activated with other cytokines, including IL-1, tumor necrosis factor, and platelet-derived growth factor, as well as phorbol esters and agents that increase intracellular cyclic AMP. Phorbol Esters 179-193 interleukin 6 Homo sapiens 19-23 1716487-2 1990 In this study, we report the effects of prostaglandin E2 (PGE2), and two other cAMP-elevating agents, dibutyryl cAMP and 3-isobutyl-1-methyl-xanthine, on the in vitro LPS-induced production of IL 6, IL 1 alpha, IL 1 beta and TNF alpha by human monocytes. 1-Methyl-3-isobutylxanthine 121-149 interleukin 6 Homo sapiens 193-197 2208301-8 1990 The magnitude of the increase in IgG-Tet secretion in response to exogenous IL-6 was inversely related to the number of cells in culture, which was due in part to increased endogenous IL-6 production in cultures with higher cell concentrations. tetramethylenedisulfotetramine 37-40 interleukin 6 Homo sapiens 76-80 2208301-8 1990 The magnitude of the increase in IgG-Tet secretion in response to exogenous IL-6 was inversely related to the number of cells in culture, which was due in part to increased endogenous IL-6 production in cultures with higher cell concentrations. tetramethylenedisulfotetramine 37-40 interleukin 6 Homo sapiens 184-188 2208301-9 1990 Experiments including hydroxyurea in serum-free cultures indicated that IL-6-dependent enhancement of LB B cells" IgG-Tet secretion was not primarily mediated by cell growth. tetramethylenedisulfotetramine 118-121 interleukin 6 Homo sapiens 72-76 2113479-4 1990 Constitutive production of IL 6 in early passage lines could be enhanced by the phorbol ester phorbol 12-myristate 13-acetate (PMA) and recombinant (r)IL 4 but not by rIL 1 alpha or rIL 1 beta. Phorbol Esters 80-93 interleukin 6 Homo sapiens 27-31 17324269-13 2007 Like LCL-8664, UMCL01-101 was sensitive to TGF-beta1-mediated inhibition, rescued partially by IL-6, and demonstrated rapid STAT3 activation following IL-6 treatment even in the presence of TGF-beta1. umcl01-101 15-25 interleukin 6 Homo sapiens 95-99 2341859-0 1990 Interleukin-6 induction by a muramyltripeptide derivative in cancer patients. muramyltripeptide 29-46 interleukin 6 Homo sapiens 0-13 2310829-1 1990 Interleukin-6 (IL-6), a multifunctional cytokine produced in monocytes, fibroblasts, endothelial cells, and keratinocytes, is induced by a variety of stimulating signals, including lipopolysaccharide (LPS), poly (I), poly (C), IL-1, tumor necrosis factor (TNF), and platelet-derived growth factor. Poly C 217-224 interleukin 6 Homo sapiens 0-13 2258049-6 1990 In the media of a cotransformed A. nidulans strain grown on starch, IL6 activity was detected by means of a bioassay. Starch 60-66 interleukin 6 Homo sapiens 68-71 17324269-13 2007 Like LCL-8664, UMCL01-101 was sensitive to TGF-beta1-mediated inhibition, rescued partially by IL-6, and demonstrated rapid STAT3 activation following IL-6 treatment even in the presence of TGF-beta1. umcl01-101 15-25 interleukin 6 Homo sapiens 151-155 2337412-2 1990 Utilizing classical Michaelis-Menten kinetics, apparent Km and Vmax values for HSF-PLA2 of 1.34 mM and 0.47 mumol [3H]palmitic acid released/min/mg protein were obtained using dipalmitoylphosphatidylcholine (DPPC) as the substrate, and 38.0 microM and 18.8 mumol [3H]arachidonic acid released/min/mg protein with Escherichia coli as a natural substrate. [3h]arachidonic acid 263-283 interleukin 6 Homo sapiens 79-82 2183031-2 1990 We found that a fragment of the IL-6 promoter containing the site specifically binds highly purified NF-kappa B protein and the NF-kappa B protein in nuclear extracts of phorbol ester-induced Jurkat cells. Phorbol Esters 170-183 interleukin 6 Homo sapiens 32-36 2310829-1 1990 Interleukin-6 (IL-6), a multifunctional cytokine produced in monocytes, fibroblasts, endothelial cells, and keratinocytes, is induced by a variety of stimulating signals, including lipopolysaccharide (LPS), poly (I), poly (C), IL-1, tumor necrosis factor (TNF), and platelet-derived growth factor. Poly C 217-224 interleukin 6 Homo sapiens 15-19 2407240-3 1990 Other stimulators of interleukin 6 production in chondrocytes include tumour necrosis factor-alpha, polyriboinosinic: polyribocytidylic acid and bacterial lipopolysaccharide. Poly C 118-140 interleukin 6 Homo sapiens 21-34 16946718-4 2007 The P2 antagonists, suramin-, reactive blue 2-, and periodate-oxidized ATP, inhibited ATP-induced IL-6 release, whereas pyridoxal-phosphate-6-azophenyl-2",4"-disulfonic acid, adenosine 3"-phosphate 5"-phosphate, 1-[N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, and pertussis toxin did not. metaperiodate 52-61 interleukin 6 Homo sapiens 98-102 33823299-4 2021 A reduction in SP-A levels at 24 h of exposure to TiO2 NPs (concentration-dependent) or ZnO NPs (the higher concentration) was also observed, reversed by blocking the inflammatory response (by the inhibition of IL-6). tio2 nps 50-58 interleukin 6 Homo sapiens 211-215 2107353-7 1990 However, when PDGF-BB or -AB was combined with IL-1 beta or IL-6, prostanoid generation by HMC was synergistically increased up to 222-fold (IL-1 beta) or 12-fold (IL-6) above the control values, with the induction of PGE2 greater than 6-keto-PGF1 alpha greater than PGF2 alpha much greater than TXB2. 6-keto 236-242 interleukin 6 Homo sapiens 60-64 33823299-4 2021 A reduction in SP-A levels at 24 h of exposure to TiO2 NPs (concentration-dependent) or ZnO NPs (the higher concentration) was also observed, reversed by blocking the inflammatory response (by the inhibition of IL-6). zno nps 88-95 interleukin 6 Homo sapiens 211-215 17713325-0 2007 Effects of levofloxacin and doxycycline on interleukin-6 production of Chlamydia trachomatis-infected human synovial fibroblasts. Levofloxacin 11-23 interleukin 6 Homo sapiens 43-56 33808148-5 2021 A combination of tomato extract with rosemary extract inhibited UVB-induced release of IL-6 more than each of the compounds alone. UVB 64-67 interleukin 6 Homo sapiens 87-91 1688564-6 1990 In addition, stimulators of protein kinase C, including phorbol esters and teleocidin, enhanced accumulation of IL-6 mRNA. Phorbol Esters 56-70 interleukin 6 Homo sapiens 112-116 17713325-6 2007 RESULTS: The production of IL-6 was suppressed to as low as 1,800 pg/ml in the infected HFLS treated with levofloxacin or doxycycline immediately or early after infection. Levofloxacin 106-118 interleukin 6 Homo sapiens 27-31 33774344-3 2021 Compound B12, the best active compound of this series, was identified as an inhibitor of IL-6/STAT3 signaling with an IC50 of 0.61-1.11 muM in MDA-MB-231, HCT-116 and SW480 tumor cell lines with STAT3 overexpression, by inhibiting the phosphorylation of STAT3 of Tyr705 residue and the expression of STAT3 downstream genes, inducing apoptosis and inhibiting the migration of cancer cells. zwittergent 3-12 9-12 interleukin 6 Homo sapiens 89-93 17713325-7 2007 In HFLS treated with levofloxacin and doxycycline, the IL-6 levels decreased to 37,000 and 21,000 pg/ml, respectively, 48 h after infection, and levofloxacin was thus found to be less effective than doxycycline. Levofloxacin 21-33 interleukin 6 Homo sapiens 55-59 17135765-0 2007 Epigallocatechin-3-gallate inhibits secretion of TNF-alpha, IL-6 and IL-8 through the attenuation of ERK and NF-kappaB in HMC-1 cells. epigallocatechin gallate 0-26 interleukin 6 Homo sapiens 60-64 33793190-2 2021 SPEs are functionalized with antibodies specific for IL-6 through electrodeposition of a diazonium linking group and N"-ethylcarbodiimide hydrochloride (EDC) coupling, which was tracked through the use of cyclic voltammetry and Raman spectroscopy. diazynium 89-98 interleukin 6 Homo sapiens 53-57 33385878-6 2021 The anti-inflammatory effect of tramadol may help to suppress the COVID-19 related cytokine storm through decreasing interleukin (IL)-6, tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP). Tramadol 32-40 interleukin 6 Homo sapiens 117-135 17135765-2 2007 In the present study, we investigated the effect of EGCG on the secretion of TNF-alpha, IL-6 and IL-8, as well as its possible mechanism of action by using the human mast cell line (HMC-1). epigallocatechin gallate 52-56 interleukin 6 Homo sapiens 88-92 17135765-5 2007 RESULTS: EGCG (100 microM) inhibited PMA+A23187-induced TNF-alpha, IL-6 and IL-8 expression and production. epigallocatechin gallate 9-13 interleukin 6 Homo sapiens 67-71 33590576-0 2021 Possible prevention of post-partum depression by intake of omega-3 polyunsaturated fatty acids and its relationship with interleukin 6. omega-3 polyunsaturated fatty acids 59-94 interleukin 6 Homo sapiens 121-134 17135765-8 2007 CONCLUSION: EGCG inhibited the production of TNF-alpha, IL-6 and IL-8 through the inhibition of the intracellular Ca(2+) level, and of ERK1/2 and NF-kappaB activation. epigallocatechin gallate 12-16 interleukin 6 Homo sapiens 56-60 33034612-5 2020 Finally, we also observed that C18 UFAs can enhance the IgE binding ability and the degranulation capacity of human basophil KU812 cells (intracellular Ca2+, histamine, beta-Hex, and IL-6). c18 ufas 31-39 interleukin 6 Homo sapiens 183-187 17135982-0 2007 Pneumococcal peptidoglycan-polysaccharides induce the expression of interleukin-8 in airway epithelial cells by way of nuclear factor-kappaB, nuclear factor interleukin-6, or activation protein-1 dependent mechanisms. pneumococcal peptidoglycan-polysaccharides 0-42 interleukin 6 Homo sapiens 157-170 34808298-10 2022 ZJP could dose-dependently decrease the serum IL-6, MCP-1, PGE2, TNF-alpha, and VEGF level and significantly improved gastric tissue inflammatory lesions. zjp 0-3 interleukin 6 Homo sapiens 46-50 33810574-7 2021 At rest, there were no differences in BDNF between MS and controls; however, IL-6 was significantly higher in MS. Higher V O2max was associated with a shift in BDNF/IL-6 ratio from inflammation to repair (R = 0.7, p = 0.001) when considering both groups together. o2max 123-128 interleukin 6 Homo sapiens 77-81 33810574-7 2021 At rest, there were no differences in BDNF between MS and controls; however, IL-6 was significantly higher in MS. Higher V O2max was associated with a shift in BDNF/IL-6 ratio from inflammation to repair (R = 0.7, p = 0.001) when considering both groups together. o2max 123-128 interleukin 6 Homo sapiens 165-169 17673806-4 2007 [Melanoma Res 2006;16:263-265] of remission of an advanced melanoma during treatment with the cyclooxygenase, (COX) inhibitor rofecoxib can be explained by rofcoxib-mediated lowering of tumor-produced Il-6. rofecoxib 126-135 interleukin 6 Homo sapiens 201-205 17673806-5 2007 Several examples of rofecoxib"s ability to lower Il-6 in humans have been published recently in other settings, and many reports indicate that other commonly used COX inhibitors like aspirin, diclofenac, etodolac, indomethacin, naproxen, and many others, also lower Il-6 in humans. rofecoxib 20-29 interleukin 6 Homo sapiens 49-53 33804152-4 2021 We found that 13R,20-diHDHA reduced the macrophage secretion of the inflammatory cytokines, IL-6 and TNF-alpha, and thus appeared to have anti-inflammatory effects. 13r,20-dihdha 14-27 interleukin 6 Homo sapiens 92-96 34954542-6 2022 17-AAG and VER-82576 were also evaluated for their effects on the expressions of TNF-alpha, IL-6, and IL-12, which are PDCoV-induced proinflammatory cytokines. NVP-BEP800 11-20 interleukin 6 Homo sapiens 92-96 34954542-7 2022 We found that both 17-AAG and VER-82576 inhibited the expressions of TNF-alpha, IL-6, and IL-12 to varying degrees, but in a dose dependent manner. NVP-BEP800 30-39 interleukin 6 Homo sapiens 80-84 34955648-10 2021 Results: Co and Ni both significantly increased IL-6 secretion in human BSMCs at 300 muM. Cobalt 9-11 interleukin 6 Homo sapiens 48-52 33804152-8 2021 13R,20-diHDHA increased reactive oxygen species (ROS) production, and the generated ROS reduced the phosphorylation of nuclear signal transducer and activator of transcription 3 (Stat3) and the secretion of IL-6 by mammospheres. 13r,20-dihdha 0-13 interleukin 6 Homo sapiens 207-211 17673806-5 2007 Several examples of rofecoxib"s ability to lower Il-6 in humans have been published recently in other settings, and many reports indicate that other commonly used COX inhibitors like aspirin, diclofenac, etodolac, indomethacin, naproxen, and many others, also lower Il-6 in humans. rofecoxib 20-29 interleukin 6 Homo sapiens 266-270 33777681-3 2021 Mechanistically, chemotherapy-induced intestinal damage triggered the formation of an interleukin-6 (IL-6)-indoleamine 2,3-dioxygenase 1 (IDO1)-aryl hydrocarbon receptor (AHR) positive feedback loop, which accelerated kynurenine pathway metabolism in gut. Kynurenine 218-228 interleukin 6 Homo sapiens 86-99 34955648-12 2021 BSMCs transfected with OGR1-siRNA produced less IL-6 than BSMCs transfected with NT-siRNA in response to either Co or Ni stimulation. Cobalt 112-114 interleukin 6 Homo sapiens 48-52 17237271-7 2007 The interleukin 6-stimulated activation of STAT3 and Akt was inhibited not only by atiprimod but also by LY294002, a phosphoinositide-3-kinase-specific inhibitor, and by NS398, a cyclooxygenase-2-selective inhibitor. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 105-113 interleukin 6 Homo sapiens 4-17 34948051-7 2021 This IL-6 release could be blocked by a Galphaq inhibitor (YM-254890), an IKK complex inhibitor (IKK-16), and partly by a PLC inhibitor (U-73122). YM-254890 59-68 interleukin 6 Homo sapiens 5-9 20233899-7 2010 Deletion of STAT2 decreased azoxymethane/dextran sodium sulfate-induced expression and release of proinflammatory mediators, such as interleukin-6 and CCL2, and decreased interleukin-6 release from skin carcinoma cells, which then decreased STAT3 activation. Azoxymethane 28-40 interleukin 6 Homo sapiens 133-146 20233899-7 2010 Deletion of STAT2 decreased azoxymethane/dextran sodium sulfate-induced expression and release of proinflammatory mediators, such as interleukin-6 and CCL2, and decreased interleukin-6 release from skin carcinoma cells, which then decreased STAT3 activation. Azoxymethane 28-40 interleukin 6 Homo sapiens 171-184 17157040-9 2006 TBK1 knockdown inhibited poly(I:C)-induced IL-6 production in SHP-2-deficient cells. poly 25-29 interleukin 6 Homo sapiens 43-47 34965953-11 2021 CONCLUSIONS: IL-6 and HGF are potential predictive biomarkers of OS benefit from BEV+IFN in mRCC patients. bev+ 81-85 interleukin 6 Homo sapiens 13-17 34965953-11 2021 CONCLUSIONS: IL-6 and HGF are potential predictive biomarkers of OS benefit from BEV+IFN in mRCC patients. ifn 85-88 interleukin 6 Homo sapiens 13-17 34463587-11 2021 Furthermore, PDTC decreased IL-1beta-induced chondrocyte apoptosis with the upregulated COL1A1, COL2A1, COL10A1 and ACAN, as well as the down-regulated MMP1, MMP13, COX2, iNOS, IL-6, TNF-alpha, NO and PGE2, which was reversed by A20 siRNA. pyrrolidine dithiocarbamic acid 13-17 interleukin 6 Homo sapiens 177-181 34879788-4 2021 Generalized estimating equation was used to evaluate the association between exposure to PM2.5 and NO2 and the following serum cytokine levels on the 7 days preceding clinical assessment and serum collection: MCP1, IL-6, IL-8, IL-10, IL-17, IFN-alpha, and TNF-alpha. pm2.5 89-94 interleukin 6 Homo sapiens 215-219 17130674-7 2006 However, AG1478, an epidermal growth factor (EGF)-receptor inhibitor, partially decreased UTP-induced ERK phosphorylation and IL-6 expression. RTKI cpd 9-15 interleukin 6 Homo sapiens 126-130 34923957-13 2021 GLA could inhibit the phosphorylation of the signal transducer and activator of transcription 3 (STAT3) and downregulate interleukin IL-6 induced STAT3 phosphorylation in MM. glaucocalyxin A 0-3 interleukin 6 Homo sapiens 133-137 16931790-5 2006 Using the UPR inducing agent tunicamycin and selective siRNA targeting of the ATF4 and XBP1 branches of the UPR, we demonstrate that these transcription factors are essential mediators of IL8, IL6, and MCP1 expression in human aortic ECs required for maximal inflammatory gene expression in the basal state and after oxPAPC treatment. Tunicamycin 29-40 interleukin 6 Homo sapiens 193-196 34977169-8 2021 Results: AEDPPE significantly promoted the migration and invasion of HTR-8/SVneo cells, and it decreased the expression of interleukins 1 beta (IL-1beta), interleukin 6 (IL-6), and interleukin 8 (IL-8). aedppe 9-15 interleukin 6 Homo sapiens 155-168 34977169-8 2021 Results: AEDPPE significantly promoted the migration and invasion of HTR-8/SVneo cells, and it decreased the expression of interleukins 1 beta (IL-1beta), interleukin 6 (IL-6), and interleukin 8 (IL-8). aedppe 9-15 interleukin 6 Homo sapiens 170-174 34817126-1 2021 OBJECTIVES: To evaluate the serum and salivary levels of IL-1beta, IL-6, IL-17A, TNF-alpha, IL-4 and, IL-10 in patients with Oral Lichen Planus (OLP) treated with Photobiomodulation (PBM) and clobetasol propionate 0.05%. pbm 183-186 interleukin 6 Homo sapiens 67-71 16778793-5 2006 Moreover, squalene peroxides induced an initial upregulation of IL-6 production and secretion that was counteracted by PPARalpha activation, as suggested by the subsequent decrease of NF-kappaB nuclear translocation and IL-6 levels. 2,3-oxidosqualene 10-28 interleukin 6 Homo sapiens 64-68 34737220-6 2022 Ten proteins were elevated in SA versus MMA in both U-BIOPRED and BIOAIR (alpha-1-antichymotrypsin, apolipoprotein-E, complement component 9, complement factor I, macrophage inflammatory protein-3, interleukin-6, sphingomyelin phosphodiesterase 3, RANK, TGF-beta1, and glutathione S-transferase). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 30-32 interleukin 6 Homo sapiens 198-211 34507119-4 2021 First, we evaluated the effect of lupeol (100 microM) on inflammatory response induced by lipopolysaccharide (LPS) in retinal pigment epithelium cells (ARPE-19) by measuring levels of released interleukins (IL-6 and IL-8). lupeol 34-40 interleukin 6 Homo sapiens 207-211 34507119-8 2021 Treatment with lupeol (100 microM) significantly decreased IL-6 and IL-8 levels in comparison to untreated LPS-activated ARPE-19 cells. lupeol 15-21 interleukin 6 Homo sapiens 59-63 34738866-11 2021 MHBs re-expression restored a rapid clearance of HBV, which was accompanied by cytokine responses including the elevation of CXCL1, CXCL2, IL-6 and IL-33. mhbs 0-4 interleukin 6 Homo sapiens 139-143 16778793-5 2006 Moreover, squalene peroxides induced an initial upregulation of IL-6 production and secretion that was counteracted by PPARalpha activation, as suggested by the subsequent decrease of NF-kappaB nuclear translocation and IL-6 levels. 2,3-oxidosqualene 10-28 interleukin 6 Homo sapiens 220-224 17063122-6 2006 After activation with polyinosinic-polycytidylic acid, BDCs expressed higher levels of major histocompatibility complex class I, CD40, CD80, and CD83, and secreted higher levels of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, and IL-8 compared with MoDCs. tert-butyldimethylsilyl chloride 55-59 interleukin 6 Homo sapiens 234-238 34964773-9 2021 RESULTS: The result from Oncomine showed that the expression of interleukin 6 in gastric cancer (GC) patients was higher than the normal groups (P < .05). oncomine 25-33 interleukin 6 Homo sapiens 64-77 34605616-8 2021 The cytokine profiles showed IL-2, IL-5, IFN-gamma increased; other cytokines including IL-6, IL-10, TNF- alpha and TNF- beta decreased with lenvatinib therapy. lenvatinib 141-151 interleukin 6 Homo sapiens 88-92 16926159-0 2006 Pyrrolidine dithiocarbamate inhibits interleukin-6 signaling through impaired STAT3 activation and association with transcriptional coactivators in hepatocytes. pyrrolidine dithiocarbamic acid 0-27 interleukin 6 Homo sapiens 37-50 34940981-9 2021 However, as for Tregs, these cells produced more IL-10 than non-Treg CD4 T cells upon IL-6 stimulation, and these IL-10 led to the inhibition of CCR4 and CCR6. tregs 16-21 interleukin 6 Homo sapiens 86-90 34888169-7 2021 Interestingly, a common factor of UDD is the production and overall effects of inflammatory cytokines, such as interleukin-6, tumor necrosis factor-alpha, and C-reactive protein. MMV689243 34-37 interleukin 6 Homo sapiens 111-124 34749441-9 2021 In summary, oxymatrine promoted hypertrophic scar repair by decreasing HSF viability and collagen, and inducing apoptosis via autophagy inhibition. oxymatrine 12-22 interleukin 6 Homo sapiens 71-74 16926159-2 2006 Although previous studies have demonstrated that pyrrolidine dithiocarbamate (PDTC) exerts protection against inflammatory responses, its role in the regulation of IL-6 receptor signaling remains unclear. pyrrolidine dithiocarbamic acid 78-82 interleukin 6 Homo sapiens 164-168 34667145-7 2021 Ablation of XBP1 inhibited the expression of the pro-tumor cytokine signature of TAMs, including IL-6, VEGFA, and IL-4. tams 81-85 interleukin 6 Homo sapiens 97-101 16807360-10 2006 In circular muscle, exogenous PAF induced sequential formation of IL-6, H(2)O(2), IL-1beta, and PAF. Platelet Activating Factor 30-33 interleukin 6 Homo sapiens 66-70 34601984-6 2022 Flow cytometry and MTS assay were used for cell proliferation and viability analysis in pPeOp-treated gastric cancer cell lines with IL-6 or NSC74859. ppeop 88-93 interleukin 6 Homo sapiens 133-137 34601984-7 2022 The anti-tumor effect was increased when pPeOp were co-treated with IL-6, while decreased in inhibitor treatment. ppeop 41-46 interleukin 6 Homo sapiens 68-72 34245398-8 2021 Moreover, the changes in serum IL-6 (DeltaIL-6) levels from baseline to 7 days after admission significantly correlated with DeltaL-FABP and Deltaubeta2MG. deltail 37-44 interleukin 6 Homo sapiens 31-35 17072062-7 2006 In contrast, IL-6 concentration in EBC was significantly lower compared with that in BALF, while the correlation between both materials was negative (r=-0.47, P<0.05). NSC638702 35-38 interleukin 6 Homo sapiens 13-17 34517275-12 2021 The results of the present study indicated that OMT inhibited the over-activation of microglia, increased the levels of the M2 marker IL-10, decreased the levels of the M1 markers NO, TNF-alpha, IL-6, and IL-1beta, promoted the polarization of N9 microglia to the M2 phenotype, and regulated M1/M2 polarization in the microglia by inhibiting TLR4/NF-kappaB signalling, which effectively attenuated the LPS-induced inflammatory response. oxymatrine 48-51 interleukin 6 Homo sapiens 195-199 34438042-4 2021 The cholesterol-interacting agent, nystatin, which binds cholesterol without removing it from the membrane, synergized with DCA to induce IL-6 and IL-8. Nystatin 35-43 interleukin 6 Homo sapiens 138-142 34572149-8 2021 In addition, metformin, a potential inhibitor of TLR4, also decreased expression of COX-2 and IL-6 induced by co-incubation with IL-26 and palmitate. Palmitates 139-148 interleukin 6 Homo sapiens 94-98 17087030-1 2006 The purpose of the study was to compare the effect of para-aminobenzoic acid (PABA) (actipol) on tear interleukin-6 (IL-6) levels in patients with herpetic keratitis and in peripheral blood cells of volunteers in vitro. 4-Aminobenzoic Acid 78-82 interleukin 6 Homo sapiens 102-115 34632188-7 2021 Furthermore, 1,4-naphthoquinone potently suppressed the production and secretion of key proinflammatory cytokine proteins IL-8, IL-1beta, IL-10, TNF-alpha, and IL-6 in LPS-stimulated PMA-induced human THP-1 macrophages. 1,4-naphthoquinone 13-31 interleukin 6 Homo sapiens 160-164 34237666-3 2021 Limonoids are a class of triterpenoids known to prevent the release of IL-6, IL-15, IL-1alpha, IL-1beta via TNF and are also known to modulate PI3K/Akt/GSK-3beta, JNK1/2, MAPKp38, ERK1/2, and PI3K/Akt/mTOR signaling pathways and could help to avoid viral infection, persistence, and pathogenesis. Triterpenes 25-38 interleukin 6 Homo sapiens 71-75 34426376-5 2021 PM2.5 significantly augments the levels of pro-inflammatory cytokine interleukin-6 (IL-6) in bronchoalveolar lavage fluid (BALF), and this also can be reversed by TM5614, indicating its efficacy in amelioration of PM2.5-induced increases in inflammatory and pro-thrombotic factors. tm5614 163-169 interleukin 6 Homo sapiens 69-82 34426376-5 2021 PM2.5 significantly augments the levels of pro-inflammatory cytokine interleukin-6 (IL-6) in bronchoalveolar lavage fluid (BALF), and this also can be reversed by TM5614, indicating its efficacy in amelioration of PM2.5-induced increases in inflammatory and pro-thrombotic factors. tm5614 163-169 interleukin 6 Homo sapiens 84-88 17087030-1 2006 The purpose of the study was to compare the effect of para-aminobenzoic acid (PABA) (actipol) on tear interleukin-6 (IL-6) levels in patients with herpetic keratitis and in peripheral blood cells of volunteers in vitro. 4-Aminobenzoic Acid 78-82 interleukin 6 Homo sapiens 117-121 17087030-1 2006 The purpose of the study was to compare the effect of para-aminobenzoic acid (PABA) (actipol) on tear interleukin-6 (IL-6) levels in patients with herpetic keratitis and in peripheral blood cells of volunteers in vitro. 4-Aminobenzoic Acid 85-92 interleukin 6 Homo sapiens 102-115 17087030-1 2006 The purpose of the study was to compare the effect of para-aminobenzoic acid (PABA) (actipol) on tear interleukin-6 (IL-6) levels in patients with herpetic keratitis and in peripheral blood cells of volunteers in vitro. 4-Aminobenzoic Acid 85-92 interleukin 6 Homo sapiens 117-121 34729155-12 2021 In addition, as compared to control, purified SA-IgG-treated PBMCs showed a significant decrease in the expression of IL-6 and TNF-alpha. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 46-48 interleukin 6 Homo sapiens 118-122 17087030-7 2006 All study PABA concentrations exerted a modulating effect on the production of IL-6 in the peripheral blood cells in vitro. 4-Aminobenzoic Acid 10-14 interleukin 6 Homo sapiens 79-83 34195849-7 2021 It was found that cancer cells and CAFs induced the M2 polarization of TAMs by upregulating the mRNA expression levels of CD163 and CD206, and downregulating IL-6 mRNA expression and secretion in the macrophages. tams 71-75 interleukin 6 Homo sapiens 158-162 17034727-8 2006 RESULTS: The frequencies of IL-6 (-634C/G) (CC, CG and GG) genotypes were 66.7%, 19.7% and 13.6% in silicosis group, 42.9%, 42.9% and 14.2% in silica dust exposure group, 73.7%, 18.4% and 7.9% in CWP group, 51.1%, 35.6% and 13.3% in coal dust exposure group respectively. Silicon Dioxide 143-149 interleukin 6 Homo sapiens 28-32 34914243-0 2021 (Effects of low-dose dexmedetomidine combined with hydromorphone in postoperative analgesia and on the serum IL-6 and CRP levels of prostate cancer patients). Dexmedetomidine 21-36 interleukin 6 Homo sapiens 109-113 34914243-1 2021 Objective: To explore the effects of low-dose dexmedetomidine (DM) combined with hydromorphone (HM) in postoperative analgesia and on levels of serum interleukin-6 (IL-6) and C-reactive protein (CRP) in PCa patients. Dexmedetomidine 46-61 interleukin 6 Homo sapiens 150-163 34265289-7 2021 Mechanistically, the SAL analogues induced late apoptosis in colon cancer cells and necrosis in prostate cancer cells, as well as reduced secretion of interleukin 6 (IL-6) in these cells. salinomycin 21-24 interleukin 6 Homo sapiens 151-164 34265289-7 2021 Mechanistically, the SAL analogues induced late apoptosis in colon cancer cells and necrosis in prostate cancer cells, as well as reduced secretion of interleukin 6 (IL-6) in these cells. salinomycin 21-24 interleukin 6 Homo sapiens 166-170 16843089-7 2006 Nonosmotic stimulation of arginine vasopressin secretion may be mediated in part by enhanced release of muscle-derived interleukin-6 during glycogen depletion, linking exertional rhabdomyolysis to the pathogenesis of EAH. eah 217-220 interleukin 6 Homo sapiens 119-132 34608242-7 2021 Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them. Phosphatidylcholines 53-72 interleukin 6 Homo sapiens 173-186 34608242-7 2021 Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them. Phosphatidylcholines 53-72 interleukin 6 Homo sapiens 188-192 34608242-7 2021 Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them. Phosphatidylcholines 74-76 interleukin 6 Homo sapiens 188-192 34356813-6 2021 Epiloliolide effectively increased the proliferation and migration of human periodontal ligament cells without cytotoxicity and suppressed the protein expression of proinflammatory mediators and cytokines, such as iNOS, COX-2, TNF-alpha, IL-6, and IL-1beta, by downregulating NLRP3 activated by PG-LPS. 7-epi-Loliolide 0-12 interleukin 6 Homo sapiens 238-242 34227646-6 2021 Subsequently, it was demonstrated treatment with PI3K/AKT pathway inhibitor (LY294002) or Wnt/beta-catenin pathway inhibitor (Dickkopf-1, DKK-1) could further enhance the anti-inflammatory and antioxidant effects of RSV by downregulating the expression of IL-1beta, IL-6, IL-8 and TNFalpha, and the production of MDA, and increasing the activity of SOD and GSH-Px in LPS-induced HGFs. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 77-85 interleukin 6 Homo sapiens 266-270 34087700-4 2021 Similarly, PS at a dosage of 20 and 40 mg/kg increased the concentrations of interleukin-1beta, interferon-gamma, interleukin-2, and interleukin-6 but decreased triglyceride, total cholesterol, and low-density lipoprotein cholesterol content of serum (P < 0.05). Phytosterols 11-13 interleukin 6 Homo sapiens 133-146 34573098-8 2021 Treatment with RTA402 results in antiapoptotic, antioxidative stress, anti-inflammatory, and myelin-preserving effects on retinal ganglion cell (RGC) survival and visual function via regulation of NQO1 and HO-1, reduced IL-6 and Iba1 expression in macrophages, and promoted microglial expression of TGF-beta and Ym1 + 2 in the retina and optic nerve. bardoxolone methyl 15-21 interleukin 6 Homo sapiens 220-224 17013434-5 2006 It has been demonstrated that thalidomide inhibits TNFalpha, IL-5, IL-6, IL-8, IL-12 production and increases production of IL-2, IL-10 and INFgamma. Thalidomide 30-41 interleukin 6 Homo sapiens 67-71 34486261-12 2021 Administration of GSK650394, a SGK1 inhibitor, significantly increased IL-6 self-induced mRNA expression in cultured dispersed NP cells and 16HBE cells. 2-cyclopentyl-4-(5-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl)-benzoic acid 18-27 interleukin 6 Homo sapiens 71-75 34183381-6 2021 According to our results, the administration of 3-hydroxykynurenine as part of the treatment approach for sepsis or as an adjuvant therapy might reduce the overproduction of IL-6, which is responsible for severe endotoxemia, and ultimately improve the survival rates of patients with sepsis. 3-hydroxykynurenine 48-67 interleukin 6 Homo sapiens 174-178 16787522-1 2006 It has been reported that urinary interleukin-6 (IL-6) and IL-8 levels are decreased in adult diabetic women with asymptomatic bacteriuria (ASB) when compared with non-diabetic women with ASB. asb 140-143 interleukin 6 Homo sapiens 34-47 34177139-4 2021 CS is marked by elevated levels of inflammatory cytokines, mainly interleukin-6 (IL-6), IL-8, IL-10, tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma). Cesium 0-2 interleukin 6 Homo sapiens 66-79 34177139-4 2021 CS is marked by elevated levels of inflammatory cytokines, mainly interleukin-6 (IL-6), IL-8, IL-10, tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma). Cesium 0-2 interleukin 6 Homo sapiens 81-85 34353270-14 2022 In addition, coculture with IL-6 significantly prevented the inhibition of phosphorylation of JAK2 and STAT3 by DHE treatment, and partly reversed the effect of DHE on ESCC cells. Dihydroergotamine 112-115 interleukin 6 Homo sapiens 28-32 34353270-14 2022 In addition, coculture with IL-6 significantly prevented the inhibition of phosphorylation of JAK2 and STAT3 by DHE treatment, and partly reversed the effect of DHE on ESCC cells. Dihydroergotamine 161-164 interleukin 6 Homo sapiens 28-32 34353270-15 2022 Moreover, DHE treatment significantly down-regulated the expression of PLK1, which was partly reversed by IL-6 coculture. Dihydroergotamine 10-13 interleukin 6 Homo sapiens 106-110 34204596-10 2021 IL-6 is implicated in resistance to enzalutamide. enzalutamide 36-48 interleukin 6 Homo sapiens 0-4 16787522-1 2006 It has been reported that urinary interleukin-6 (IL-6) and IL-8 levels are decreased in adult diabetic women with asymptomatic bacteriuria (ASB) when compared with non-diabetic women with ASB. asb 140-143 interleukin 6 Homo sapiens 49-53 16683059-7 2006 Treatment with glucocorticoids together with DETA-NO 1 hr pre and 4 hr post BPDOE-CDLs reduced serum amylase, lipase, C-reactive protein, IL-6, IL-10, hsp72, and 8-isoprostane as well as pancreatic and lung myeloperoxidase. bpdoe-cdls 76-86 interleukin 6 Homo sapiens 138-142 34212125-10 2021 A positive relation between Delta-F2-isoprostane factor and change in IL-6 was observed (r = 0.642, P = 0.062). delta-f2-isoprostane 28-48 interleukin 6 Homo sapiens 70-74 34300310-4 2021 The primary endpoint was the effect of dexmedetomidine on the interleukin-6 (IL-6) level measured at pre-operation (Pre-OP), before HIPEC initiation (Pre-HIPEC), immediately after HIPEC; after the end of the operation; and on postoperative day (POD) 1. Dexmedetomidine 39-54 interleukin 6 Homo sapiens 62-75 34300310-4 2021 The primary endpoint was the effect of dexmedetomidine on the interleukin-6 (IL-6) level measured at pre-operation (Pre-OP), before HIPEC initiation (Pre-HIPEC), immediately after HIPEC; after the end of the operation; and on postoperative day (POD) 1. Dexmedetomidine 39-54 interleukin 6 Homo sapiens 77-81 35398417-4 2022 Here, we evaluated the associations between PM10, NO2 and O3 exposure (on the day of the blood sample collection and on the day before, and the mean annual residential level) and levels of the inflammatory biomarkers high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-1beta, IL-6, IL-8, IL-10, IL-17A, IL-22, and tumor necrosis factor alpha. pm10 44-48 interleukin 6 Homo sapiens 286-290 16511915-9 2006 These effects of simvastatin on IL-6 and IL-8 production and cell proliferation were reversed in the presence of mevalonic acid or geranylgeranyl-pyrophosphate, but not with farnesyl-pyrophosphate. geranylgeranyl pyrophosphate 131-159 interleukin 6 Homo sapiens 32-36 35596974-10 2022 It was confirmed that NF-kappaB is an important factor in porcine embryos by treated ammonium pyrrolidinedithiocarbamate (APDC 0.1 muM, an inhibitor of NF-kappaB) affected NF-kappaB protein expression, IL-6 expression, and blastocyst production. pyrrolidine dithiocarbamic acid 85-120 interleukin 6 Homo sapiens 202-206 35460295-3 2022 Thus, we investigated leg IL-6 release in response to beta2 -agonist salbutamol in lean young men at rest and in recovery from resistance exercise. Albuterol 69-79 interleukin 6 Homo sapiens 26-30 34114792-7 2021 Markedly, NCO-sP(EO-stat-PO)-rich samples induced a significantly reduced release of proinflammatory cytokines, IL-1beta, IL-6, and IL-8. nco-sp 10-16 interleukin 6 Homo sapiens 122-126 34257799-14 2021 The concentrations of IL-1beta, IL-6, and IL-8 in the plasma were all decreased upon ZnO administration. Zinc Oxide 85-88 interleukin 6 Homo sapiens 32-36 34199865-8 2021 When mechanically stressed HPdLF were additionally stimulated with LPS, the PGE2 and IL6 secretion, as well as monocyte adhesion, were further increased in PA-treated cultures. Palmitates 156-158 interleukin 6 Homo sapiens 85-88 34072916-5 2021 However, auranofin significantly inhibited the levels of NO, monocyte chemoattractant protein-1, and pro-inflammatory cytokines, such as interleukin (IL)-1beta, tumor necrosis factor-alpha, and IL-6, which had been increased by co-treatment with PA and LPS. Auranofin 9-18 interleukin 6 Homo sapiens 194-198 35211881-9 2022 Molecular docking analysis showed combinations between these targets and EGCG, and the interaction between EGCG and the targets IL-6 and EGFR was confirmed by using molecular dynamic simulation. epigallocatechin gallate 107-111 interleukin 6 Homo sapiens 128-132 16933469-9 2006 Stimulated human fibroblasts also rapidly expressed interleukin-6 and early growth response-1 and these proteins were found to mediate serum-induced fibroblast proliferation as proliferation could be significantly abrogated with interleukin-6 and early growth response-1 antisense oligonucelotides. oligonucelotides 281-297 interleukin 6 Homo sapiens 52-65 35612681-11 2022 In conclusion, TNF-alpha up-regulated IL-6 and MMPs, while bioflavonoids and PBM down-regulated MMP-2 and MMP-9 syntheses; GSE also decreased IL-6 synthesis, demonstrating the individual promising potential of these therapies for ulceration management. pbm 77-80 interleukin 6 Homo sapiens 142-146 34072916-6 2021 Moreover, the expression of inducible NO synthase, IL-1beta, and IL-6 mRNA and protein levels increased by PA and LPS were reduced by auranofin. Auranofin 134-143 interleukin 6 Homo sapiens 65-69 16933469-9 2006 Stimulated human fibroblasts also rapidly expressed interleukin-6 and early growth response-1 and these proteins were found to mediate serum-induced fibroblast proliferation as proliferation could be significantly abrogated with interleukin-6 and early growth response-1 antisense oligonucelotides. oligonucelotides 281-297 interleukin 6 Homo sapiens 229-242 35118716-15 2022 In addition, a unit increase in ACB was associated with a significantly higher TNF-alpha and IL-6. acb 32-35 interleukin 6 Homo sapiens 93-97 35486494-7 2022 20 muM and 40 muM lupeol induced cell apoptosis, enhanced oxidative stress and restrained immune response in nasopharyngeal carcinoma cells to some extent, as evidenced by the elevation of apoptotic rate, Bax and cleaved caspase-3 expression, ROS production and malondialdehyde level, and reduction of levels of Bcl-2, MMP, superoxide dismutase, TNF-alpha, IL-6 and IL-1beta. lupeol 18-24 interleukin 6 Homo sapiens 357-361 16491457-4 2006 Coumestrol, daidzein and genistein stimulate the expression of the ERE-dependent reporter in MVLN cells and repress the activity of the IL-6 promoter in U2OS cells in a dose-dependent manner. Genistein 25-34 interleukin 6 Homo sapiens 136-140 35429917-9 2022 RESULTS: In LMM, a two-fold increase in urinary cesium (Cs) and chromium (Cr) was statistically associated with -35.22% (95% confidence interval (CI): -53.17, -10.40) changes in interleukin 6 (IL-6) and -11.13% (95 %CI: -20.67, -0.44) in IL-8. Cesium 48-54 interleukin 6 Homo sapiens 178-191 35429917-9 2022 RESULTS: In LMM, a two-fold increase in urinary cesium (Cs) and chromium (Cr) was statistically associated with -35.22% (95% confidence interval (CI): -53.17, -10.40) changes in interleukin 6 (IL-6) and -11.13% (95 %CI: -20.67, -0.44) in IL-8. Cesium 48-54 interleukin 6 Homo sapiens 193-197 35460295-7 2022 RESULTS: Average leg IL-6 release was 1.7-fold higher (p=0.01) for salbutamol than placebo, being 138+-76 and 79+-66 pg min-1 (mean+-SD) for salbutamol and placebo, respectively, but IL-6 release was not significantly different between treatments within specific sampling points at rest and after exercise. Albuterol 67-77 interleukin 6 Homo sapiens 21-25 35460295-7 2022 RESULTS: Average leg IL-6 release was 1.7-fold higher (p=0.01) for salbutamol than placebo, being 138+-76 and 79+-66 pg min-1 (mean+-SD) for salbutamol and placebo, respectively, but IL-6 release was not significantly different between treatments within specific sampling points at rest and after exercise. Albuterol 67-77 interleukin 6 Homo sapiens 183-187 35460295-7 2022 RESULTS: Average leg IL-6 release was 1.7-fold higher (p=0.01) for salbutamol than placebo, being 138+-76 and 79+-66 pg min-1 (mean+-SD) for salbutamol and placebo, respectively, but IL-6 release was not significantly different between treatments within specific sampling points at rest and after exercise. Albuterol 141-151 interleukin 6 Homo sapiens 21-25 35429917-9 2022 RESULTS: In LMM, a two-fold increase in urinary cesium (Cs) and chromium (Cr) was statistically associated with -35.22% (95% confidence interval (CI): -53.17, -10.40) changes in interleukin 6 (IL-6) and -11.13% (95 %CI: -20.67, -0.44) in IL-8. Cesium 56-58 interleukin 6 Homo sapiens 178-191 35429917-9 2022 RESULTS: In LMM, a two-fold increase in urinary cesium (Cs) and chromium (Cr) was statistically associated with -35.22% (95% confidence interval (CI): -53.17, -10.40) changes in interleukin 6 (IL-6) and -11.13% (95 %CI: -20.67, -0.44) in IL-8. Cesium 56-58 interleukin 6 Homo sapiens 193-197 35460295-8 2022 Muscle IL-6 mRNA was 1.5 and 1.7-fold higher (p=0.001) for salbutamol than placebo 1/2 and 5 h after exercise, respectively, whereas no significant treatment differences were observed for TNF-alpha mRNA. Albuterol 59-69 interleukin 6 Homo sapiens 7-11 17153635-6 2006 Both TRD and TRD-Cl, more effectively than TauCl, inhibited the production of IL-6 by stimulated macrophages. taucl 43-48 interleukin 6 Homo sapiens 78-82 35460295-9 2022 CONCLUSIONS: Beta2 -adrenergic stimulation with high doses of the selective beta2 -agonist salbutamol, preceeded by 4 consecutive daily doses, induces transcription of IL-6 in skeletal muscle in response to resistance exercise and increases muscle IL-6 release in lean individuals. Albuterol 91-101 interleukin 6 Homo sapiens 168-172 35460295-9 2022 CONCLUSIONS: Beta2 -adrenergic stimulation with high doses of the selective beta2 -agonist salbutamol, preceeded by 4 consecutive daily doses, induces transcription of IL-6 in skeletal muscle in response to resistance exercise and increases muscle IL-6 release in lean individuals. Albuterol 91-101 interleukin 6 Homo sapiens 248-252 35452996-7 2022 Evaluation of the cell death phenotype revealed that glutaminolysis inhibitory treatment with CB839 or a low-glutamine medium significantly promoted the proliferation of beta-galactosidase-positive and IL-6/IL-8 secretory cells among X-irradiated tumor cells, corresponding to an increase in the senescent cell population. Glutamine 109-118 interleukin 6 Homo sapiens 202-206 35093485-9 2022 Exposure to specific antigens induced CD38+ B cells to produce IL-6, that converted Tregs to Th17 cells. tregs 84-89 interleukin 6 Homo sapiens 63-67 16286589-0 2005 Myocardial ischemia induces interleukin-6 and tissue factor production in patients with coronary artery disease: a dobutamine stress echocardiography study. Dobutamine 115-125 interleukin 6 Homo sapiens 28-41 35437207-7 2022 RESULTS: EKH significantly induced IL-6 and IL-8 in NHDF and HMVEC-dBl. 5-Chlorotubercidin 9-12 interleukin 6 Homo sapiens 35-39 35247857-1 2022 The innovation of this work lies in the trace detection of inflammatory biomarkers (IL-6, hs-CRP) in human exhaled breath condensate on the developed EBC-SURE platform as a point-of-care aid for respiratory disorder diagnosis. NSC638702 150-153 interleukin 6 Homo sapiens 84-88 35247857-4 2022 The lowest detection limits for IL-6 and hs-CRP detection in EBC were found to be 3.2 pg/mL and 4 pg/mL respectively. NSC638702 61-64 interleukin 6 Homo sapiens 32-36 35247857-7 2022 EBC-SURE generated highly selective IL-6 and hs-CRP responses in the presence of other non-specific cytokines. NSC638702 0-3 interleukin 6 Homo sapiens 36-40 16263508-5 2005 Exposure to OE-UDP, OE-DEP, UDP, DEP, and 2,3,7,8-tetrachlorodibenzo-p-dioxin led to a greater increase of interleukin (IL)-8, tumor necrosis factor-alpha, and cyclooxygenase-2 mRNA expression than did the stripped particles, whereas sUDP, sDEP, UDP, and DEP led to a greater production of C-reactive protein and IL-6 mRNA. oe-dep 20-26 interleukin 6 Homo sapiens 313-317 35421875-9 2022 In addition, the effect of ZYF on lipopolysaccharide (LPS)-induced IL-6 was investigated. ZYF 27-30 interleukin 6 Homo sapiens 67-71 35624084-9 2022 However, endotoxin-producing Enterobacteriaceae are thought to produce glycerate, triggering a peroxisome proliferator- activated receptor-alpha-mediated decrease in IL-6 level and fat accumulation in PHC-like patients. glyceric acid 71-80 interleukin 6 Homo sapiens 166-170 35192550-7 2022 Strikingly, a 4-fold decrease in FAHFAs was provoked by acute aerobic running in NWT, an effect that negatively correlated with circulating IL-6, neither of which was observed in the OWT group. fahfas 33-39 interleukin 6 Homo sapiens 140-144 16211268-8 2005 NF-kappaB nuclear translocation and IL-6 secretion induced by UVB and UVA were dramatically inhibited by treatment of EGCG. epigallocatechin gallate 118-122 interleukin 6 Homo sapiens 36-40 35596173-7 2022 MiR-16-5p was negatively correlated with interleukin (IL)-6, intercellular adhesion molecule (ICAM) and vascular cell adhesion molecule (VCAM) (p = 0.002, p < 0.001, p = 0.016, respectively), whereas miR-126 was positively correlated with VCAM (p < 0.001). mir-16-5p 0-9 interleukin 6 Homo sapiens 41-59 15890711-9 2005 Finally, in normal muscle strips treated with IL-1beta electrical field stimulation (EFS)-induced contraction was partially restored by indomethacin or by the PAF antagonist CV3988 and was completely restored by the combination of CV3988 and indomethacin, whereas in strips treated with IL-6, EFS-induced contraction was partially restored by the PAF antagonist CV3988 and not affected by indomethacin. CV 3988 231-237 interleukin 6 Homo sapiens 287-291 35234365-6 2022 Blood endotoxin peak levels in the KCEA group were significantly lower, resulting in a significant suppression of IL-6, TNF-alpha and procalcitonin, which improved mean arterial pressure and significantly lowered vasopressor demand, thereby protecting organ function and improving survival time and rate. kcea 35-39 interleukin 6 Homo sapiens 114-118 15890711-9 2005 Finally, in normal muscle strips treated with IL-1beta electrical field stimulation (EFS)-induced contraction was partially restored by indomethacin or by the PAF antagonist CV3988 and was completely restored by the combination of CV3988 and indomethacin, whereas in strips treated with IL-6, EFS-induced contraction was partially restored by the PAF antagonist CV3988 and not affected by indomethacin. CV 3988 231-237 interleukin 6 Homo sapiens 287-291 35588020-9 2022 PPD, BOP, PI, and CAL had significantly positive correlations with salivary IL-6, TRP, PA, QA, and serum KYN and significantly negative correlations with salivary KYN/TRP ratio. cal 18-21 interleukin 6 Homo sapiens 76-80 35018747-10 2022 IL-6 was positively correlated, while IL-8, IL-10 and TNF-alpha were negatively correlated, with retinol and 25OHD. Vitamin A 97-104 interleukin 6 Homo sapiens 0-4 16141532-2 2005 Previous studies have demonstrated that CKBM is capable of triggering the release of IL-6 and TNFalpha from human peripheral blood mononuclear cells, and its anti-tumorigenic activity has been demonstrated in nude mice with gastric cancer. ckbm 40-44 interleukin 6 Homo sapiens 85-89 35583056-9 2022 Paeonol treatment concentration-dependently suppressed LPS induced mRNA expression of inflammatory cytokines including TNF-alpha, IL-1beta, IL-6, and IL-12 by BV2 microglia. paeonol 0-7 interleukin 6 Homo sapiens 140-144 35104780-8 2022 Collectively, our results demonstrated that DoPE inhibited IL-6 expression by reducing ROS generation, suppressing ERK phosphorylation, and inhibiting translocation of NF-kB p65 and NF-kB activity in PM10-stimulated HaCaT cells, suggesting that DoPE can be useful for the resolution of the inflammation caused by IL-6. pm10 200-204 interleukin 6 Homo sapiens 59-63 35134851-10 2022 Sulprostone intensified the mRNA levels of IL-6 together with interferon-gamma (IFN-gamma), while L-798,106 stimulated the mRNA expression of IL-10 and Arg-1 in a dose-dependent manner. sulprostone 0-11 interleukin 6 Homo sapiens 43-47 35562918-6 2022 Moreover, blockade of Interleukin (IL)-6 and Intercellular Adhesion Molecule (ICAM)-1 in cocultures significantly decreased the expansion of Tregs, suggesting an IL-6 and ICAM-1 dependent pathway. tregs 141-146 interleukin 6 Homo sapiens 22-40 16141532-6 2005 Treatment of CKBM alone induced the release of IL-10 and IFNgamma, but not IL-1beta, IL-4, IL-6 and TNFbeta, while increase of intracellular Ca2+ concentration by A23187 triggered the release of IL-10 only. ckbm 13-17 interleukin 6 Homo sapiens 91-95 35562918-6 2022 Moreover, blockade of Interleukin (IL)-6 and Intercellular Adhesion Molecule (ICAM)-1 in cocultures significantly decreased the expansion of Tregs, suggesting an IL-6 and ICAM-1 dependent pathway. tregs 141-146 interleukin 6 Homo sapiens 162-166 16266860-9 2005 The neonates assigned to HFOV benefited from early and sustained improvement in gas exchange, with earlier extubation and lower incidence of CLD, as compared to the neonates assigned to sIMV treatment, and showed a significant reduction of serum IL-6, IL-8 and IL-10 over time only when the HFOV treatment was administered. hfov 25-29 interleukin 6 Homo sapiens 246-250 35625671-9 2022 The expression levels of CD33+ leukocytes and circulating IL-6 were higher (p < 0.05) among patients with arterial oxygen partial pressure-to-fractional inspired oxygen (PaO2/FiO2) ratios below 13.3 kPa compared to in the remaining patients. fio2 175-179 interleukin 6 Homo sapiens 58-62 35432570-10 2022 The molecular docking results showed effective ingredients (quercetin, kaempferol, and 7-methoxy-2-methyl isoflavone) have good docking results with targets (IL-6, PTGS2, and TNF). 7-methoxy-2-methyl isoflavone 87-116 interleukin 6 Homo sapiens 158-162 35216089-7 2022 In CD biopsies inflammation markers IL-1beta and IL-6 were increased in the enterocytes, and also in Pot-CD before the onset of the intestinal lesion and in GFD-CD. gfd-cd 157-163 interleukin 6 Homo sapiens 49-53 35216089-8 2022 The inflammatory markers pNF-kappaB, pERK, IL-1beta, and IL-6 were increased and persistent in CD organoids; these organoids were more sensitive to P31-43 and Lox stimuli compared with CTR organoids. cd organoids 95-107 interleukin 6 Homo sapiens 57-61 16266860-10 2005 In addition, at days 3 and 5, the IL-6 levels were significantly lower in the HFOV group as compared to sIMV patients. hfov 78-82 interleukin 6 Homo sapiens 34-38 35204178-5 2022 Improved antioxidant capacity of O-EGCG was observed, and there was a significant decrease in the inflammatory markers (IL-1beta, IL-6, and TNF-alpha) when O-EGCG was applied as compared to EGCG. epigallocatechin gallate 190-194 interleukin 6 Homo sapiens 130-134 16171665-1 2005 STUDY OBJECTIVE: To investigate the effect of tramadol on the production of serum interleukin (IL) 6, IL-10, and IL-2 and soluble (s) IL-2 receptor (R), thereby evaluating its effects on the proinflammatory and anti-inflammatory responses and immune function in cancer patients undergoing conventional pulmonary lobectomy. Tramadol 46-54 interleukin 6 Homo sapiens 82-100 35097067-9 2022 During the treatment, the lymphocyte count, ESR, IL-6, serum ferritin, LDH, CK-MB, hs-CRP and D-dimer levels all improved gradually, indicating that both Arbidol and methylprednisolone therapy were contributed to improving the condition of COVID-19 patients. umifenovir 154-161 interleukin 6 Homo sapiens 49-53 35431964-5 2022 Meanwhile, miR-130a-3p could ameliorate pulmonary lesions by downregulating the secretion of inflammatory cytokines (IL-1beta, IL-6, TNF-alpha, and TGF-beta1) and the deposition of ECM (alpha-SMA, FN, HYP, and collagen) in the inflammatory and fibrotic phase, respectively. mir-130a-3p 11-22 interleukin 6 Homo sapiens 127-131 35351947-5 2022 In addition, AM9928 inhibited the secretion of IL-6, IL-8, and VEGF-A from TNBC cells. 3-Pyrroline 13-19 interleukin 6 Homo sapiens 47-51 16134057-14 2005 Dust-induced expression of IL-6 precedes that of TNF and the induction pathways differ with regard to staurosporine sensitivity. Staurosporine 102-115 interleukin 6 Homo sapiens 27-31 35249562-0 2022 Omega-3 Polyunsaturated Fatty Acids can Reduce IL-6 and TNF Levels in Patients with Cancer. omega-3 polyunsaturated fatty acids 0-35 interleukin 6 Homo sapiens 47-51 35104780-5 2022 We demonstrated that DoPE suppressed PM10-induced expressions of IL-6 mRNA and protein in human HaCaT keratinocytes. pm10 37-41 interleukin 6 Homo sapiens 65-69 35228811-11 2022 Conclusion: TIGIT+Tregs levels are significantly reduced in ACS, accompanied by upregulated IL-6 and downregulated TGF-beta expression. tregs 18-23 interleukin 6 Homo sapiens 92-96 35087822-4 2021 While preferentially dependent on canonical STING, we demonstrate that genotoxic DNA damage induced by camptothecin (CPT) also drove IL-6 production through non-canonical STING signaling in selected cancer cells. Camptothecin 103-115 interleukin 6 Homo sapiens 133-137 35087822-4 2021 While preferentially dependent on canonical STING, we demonstrate that genotoxic DNA damage induced by camptothecin (CPT) also drove IL-6 production through non-canonical STING signaling in selected cancer cells. Camptothecin 117-120 interleukin 6 Homo sapiens 133-137 15937058-6 2005 Cross-linking CD4 molecules (XLCD4) with anti-CD4 mAbs and goat anti-mouse IgG (GAM) resulted in high levels of IL-6, TNF-alpha and IFN-gamma but no IL-10 production by CD14(+) monocytes. xlcd4 29-34 interleukin 6 Homo sapiens 112-116 35265066-5 2022 We also demonstrated that addition of CDDO-Me to tri-cultures enhanced T cell-mediated reductions in CCL2, VEGF and IL-6 production in a contact-independent manner. bardoxolone methyl 38-45 interleukin 6 Homo sapiens 116-120 35222804-8 2022 Furthermore, by utilizing the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC), we confirmed that NF-kappaB mediated IL-6/FGF23 to regulate the Cr(VI)-induced L02 hepatocyte premature senescence, whilst the concentration of intracellular Ca2+ was not influenced by PDTC. pyrrolidine dithiocarbamic acid 50-77 interleukin 6 Homo sapiens 123-127 35222804-8 2022 Furthermore, by utilizing the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC), we confirmed that NF-kappaB mediated IL-6/FGF23 to regulate the Cr(VI)-induced L02 hepatocyte premature senescence, whilst the concentration of intracellular Ca2+ was not influenced by PDTC. pyrrolidine dithiocarbamic acid 79-83 interleukin 6 Homo sapiens 123-127 16008970-4 2005 Interleukin-6 (IL-6) in EBC was measured by a specific enzyme immunoassay. NSC638702 24-27 interleukin 6 Homo sapiens 0-13 35222804-8 2022 Furthermore, by utilizing the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC), we confirmed that NF-kappaB mediated IL-6/FGF23 to regulate the Cr(VI)-induced L02 hepatocyte premature senescence, whilst the concentration of intracellular Ca2+ was not influenced by PDTC. pyrrolidine dithiocarbamic acid 271-275 interleukin 6 Homo sapiens 123-127 16008970-4 2005 Interleukin-6 (IL-6) in EBC was measured by a specific enzyme immunoassay. NSC638702 24-27 interleukin 6 Homo sapiens 15-19 16008970-11 2005 IL-6 level in EBC was correlated positively with AHI (r = 0.441, P < 0.05), ODI(4) (r = 0.533, P < 0.05), and negatively with minimal oxygen saturation (r = -0.529, P < 0.05). NSC638702 14-17 interleukin 6 Homo sapiens 0-4 35140310-6 2022 Conversely, the gene expression of IL-6 and IL-1beta cytokines indicated a significant decrease after application of HA-LIG, thus exhibiting a greater antiflammatory power than HA-CYN. ha-lig 117-123 interleukin 6 Homo sapiens 35-39 16008970-14 2005 The levels of IL-6 in EBC are associated with the severity of OSAHS and may prove to be useful in monitoring of airway inflammation in OSAHS. NSC638702 22-25 interleukin 6 Homo sapiens 14-18 15689417-0 2005 Oxidative stress mediates sodium arsenite-induced expression of heme oxygenase-1, monocyte chemoattractant protein-1, and interleukin-6 in vascular smooth muscle cells. sodium arsenite 26-41 interleukin 6 Homo sapiens 122-135 35204104-6 2022 In addition, HC-EA, quercitrin, and hyperoside attenuated UVB-induced inflammatory mediators, including IL-6, IL-8, COX-2, and iNOS. hc-ea 13-18 interleukin 6 Homo sapiens 104-108 35071884-7 2022 To establish the anticancer mechanism of LAS-based bioconjugates, the levels of interleukin 6 (IL-6) and reactive oxygen species (ROS) were measured; the tested compounds significantly reduced the release of IL-6, while the level of ROS was significantly higher in all the cell lines studied. Lasalocid 41-44 interleukin 6 Homo sapiens 80-93 35071884-7 2022 To establish the anticancer mechanism of LAS-based bioconjugates, the levels of interleukin 6 (IL-6) and reactive oxygen species (ROS) were measured; the tested compounds significantly reduced the release of IL-6, while the level of ROS was significantly higher in all the cell lines studied. Lasalocid 41-44 interleukin 6 Homo sapiens 95-99 35071884-7 2022 To establish the anticancer mechanism of LAS-based bioconjugates, the levels of interleukin 6 (IL-6) and reactive oxygen species (ROS) were measured; the tested compounds significantly reduced the release of IL-6, while the level of ROS was significantly higher in all the cell lines studied. Lasalocid 41-44 interleukin 6 Homo sapiens 208-212 15652235-5 2005 Histamine induced concentration- and time-dependent production of granulocyte-macrophage-colony stimulating factor (GM-CSF), interleukin (IL)-8 and IL-6, which was completely blocked by olopatadine, an H1 antagonist. Olopatadine Hydrochloride 186-197 interleukin 6 Homo sapiens 148-152 15502968-7 2005 The production of cytokines (TNF-alpha, IL-6, and IL-10) by monocytes of patients with tetramine poisoning was much lower than normal controls (P<0.001), and was significantly increased after HP and CVVH in the survivors (TNF-alpha, IL-6, IL-10, P<0.05, P<0.01, P<0.05, respectively). tetramethylenedisulfotetramine 87-96 interleukin 6 Homo sapiens 40-44 34991659-6 2022 Reciprocally, IL-6 produced by TNBC cells activated the JAK2/STAT3 axis to induce TGF-beta1 secretion by TAMs, thus constituted a feed-forward circuit. tams 105-109 interleukin 6 Homo sapiens 14-18 34991659-8 2022 Thus, our findings document that the interactive dialogue between TNBC cells and TAMs promotes sustained activation of HLF in tumor cells through the IL-6-TGF-beta1 axis. tams 81-85 interleukin 6 Homo sapiens 150-154 34991668-9 2022 Blocking IL6 in the CM from M1-like TAMs could significantly weaken its effects on the colony forming, invasion, migration, microsphere forming and xenograft forming abilities of OSCC cells. tams 36-40 interleukin 6 Homo sapiens 9-12 34991668-14 2022 CONCLUSIONS: We proposed that M1-like TAMs could cascade a mesenchymal/stem-like phenotype of OSCC via the IL6/Stat3/THBS1 feedback loop. tams 38-42 interleukin 6 Homo sapiens 107-110 35396024-5 2022 Elevated proinflammatory cytokines (specifically, interleukin-6) in CSF imply the role of neuroinflammation resulting in activation of the tryptophan-kynurenine pathway. Kynurenine 150-160 interleukin 6 Homo sapiens 50-63 15502968-7 2005 The production of cytokines (TNF-alpha, IL-6, and IL-10) by monocytes of patients with tetramine poisoning was much lower than normal controls (P<0.001), and was significantly increased after HP and CVVH in the survivors (TNF-alpha, IL-6, IL-10, P<0.05, P<0.01, P<0.05, respectively). tetramethylenedisulfotetramine 87-96 interleukin 6 Homo sapiens 236-240 16435581-3 2005 In addition, the stimulation of IL-6 release also was reduced by the addition of pyrrolidine dithiocarbamate or NF-kappaB SN50, which has been reported as potent NF-kappaB inhibitor. pyrrolidine dithiocarbamic acid 81-108 interleukin 6 Homo sapiens 32-36 16435585-5 2005 The amount of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1alpha, IL-1beta, IL-6, and IL-8 in PBMC culture supernatant was significantly increased in the lipopolysaccaride (LPS)- or desferrioxamine (DFX)-treated cells compared with unstimulated cells. lipopolysaccaride 162-179 interleukin 6 Homo sapiens 84-88 15935563-1 2005 This is a unifying theory that cholesterol metabolites (isoprenoids) are an integral component of the signaling pathway for interleukin-6 (IL-6) mediated inflammation. Terpenes 56-67 interleukin 6 Homo sapiens 124-137 15935563-1 2005 This is a unifying theory that cholesterol metabolites (isoprenoids) are an integral component of the signaling pathway for interleukin-6 (IL-6) mediated inflammation. Terpenes 56-67 interleukin 6 Homo sapiens 139-143 15579413-2 2004 Exposure of AMs to silica in vitro up-regulated the messenger RNA (mRNA) levels of three genes [interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein-2 (MIP-2)] without a concomitant increase in the protein levels. Silicon Dioxide 19-25 interleukin 6 Homo sapiens 96-109 15579413-2 2004 Exposure of AMs to silica in vitro up-regulated the messenger RNA (mRNA) levels of three genes [interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein-2 (MIP-2)] without a concomitant increase in the protein levels. Silicon Dioxide 19-25 interleukin 6 Homo sapiens 111-115 15610530-9 2004 Treatment with AG490 (Janus tyrosine kinase [JAK] inhibitor) and LY294002 (PI3-Kinase inhibitor) inhibited IL-6-mediated upregulation of bFGF mRNA and protein secretion. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 65-73 interleukin 6 Homo sapiens 107-111 15505230-4 2004 In the extracellular environment, HOCl and TauCl may directly neutralize interleukin 6 (IL-6) and several metalloproteinases, while HOCl increases the capacity of alpha(2)-macroglobulin to bind Tumor Necrosis Factor-alpha, IL-2, and IL-6, and facilitates the release of various growth factors. taucl 43-48 interleukin 6 Homo sapiens 73-86 15505230-4 2004 In the extracellular environment, HOCl and TauCl may directly neutralize interleukin 6 (IL-6) and several metalloproteinases, while HOCl increases the capacity of alpha(2)-macroglobulin to bind Tumor Necrosis Factor-alpha, IL-2, and IL-6, and facilitates the release of various growth factors. taucl 43-48 interleukin 6 Homo sapiens 88-92 15464826-0 2004 Influence of 8-bromo-cyclicAMP on interleukin -6 and -8 mRNA levels in A549 human lung epithelial cells exposed to organic dust: a time-kinetic study. 8-Bromo Cyclic Adenosine Monophosphate 13-30 interleukin 6 Homo sapiens 34-55 15464826-8 2004 At 1-1.5 h, 8-bromo-cAMP stimulated basal and dust-induced IL-6 mRNA expression and attenuated dust-induced IL-8 mRNA expression by activation of protein kinase A- (PKA), as assessed with the PKA inhibitor H-89. 8-Bromo Cyclic Adenosine Monophosphate 12-24 interleukin 6 Homo sapiens 59-63 15464826-10 2004 Thus, 8-bromo-cAMP exerted opposite action on dust-induced IL-6 and IL-8 mRNA expression with time. 8-Bromo Cyclic Adenosine Monophosphate 6-18 interleukin 6 Homo sapiens 59-63 15069691-0 2004 Thalidomide reduces serum C-reactive protein and interleukin-6 and induces response to IL-2 in a fraction of metastatic renal cell cancer patients who failed IL-2-based therapy. Thalidomide 0-11 interleukin 6 Homo sapiens 49-62 15069691-3 2004 We used thalidomide to treat patients with cancer-induced cachexia and noted that the drug significantly reduced serum levels of CRP and IL-6 to normal or near normal levels in a substantial fraction of patients. Thalidomide 8-19 interleukin 6 Homo sapiens 137-141 15069691-9 2004 Reduction of serum CRP or IL-6 levels with thalidomide may enhance the responsiveness of renal cell carcinoma to IL-2. Thalidomide 43-54 interleukin 6 Homo sapiens 26-30 15159225-7 2004 Interleukin 6 concentrations were lower after consumption of the oleic acid diet than after consumption of the LMP, TFA, and STE diets. Trans Fatty Acids 116-119 interleukin 6 Homo sapiens 0-13 15149630-1 2004 Thalidomide has antiangiogenic and immunomodulatory effects, mediated by several cytokines such as vascular endothelial growth factor (VEGF), fibroblastic growth factor (FGF-2), hepatocyte growth factor (HGF), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha). Thalidomide 0-11 interleukin 6 Homo sapiens 210-223 15149630-1 2004 Thalidomide has antiangiogenic and immunomodulatory effects, mediated by several cytokines such as vascular endothelial growth factor (VEGF), fibroblastic growth factor (FGF-2), hepatocyte growth factor (HGF), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha). Thalidomide 0-11 interleukin 6 Homo sapiens 225-229 15190969-9 2004 The increase in interleukin-6 plasma concentration was then followed (12 and 24 hrs after surgery) by a significant reduction of Pao2/ FIO2 and Pao2/PAO2 ratios (p < .05 vs. abdominal surgery). fio2 135-139 interleukin 6 Homo sapiens 16-29 15051507-8 2004 Further confirmation of cdk5 involvement in this process was based on the findings that inhibition of the kinase activity with butyrolactone-I prevents the appearance of tau of Alzheimer type in IL-6-treated neurons. 4-Butyrolactone 127-140 interleukin 6 Homo sapiens 195-199 15037536-7 2004 Patients had a mean BVAS of 11+/-1, and CRP and IL-6 were higher in the AASV group than in control subjects (34.8+/-10.5 versus 1.6+/-0.2 pg/mL, P<0.001; 9.0+/-0.7 versus 6.7+/-0.6 pg/mL, P=0.02). aasv 72-76 interleukin 6 Homo sapiens 48-52 14975696-5 2004 In a dose-dependent manner, ibudilast suppressed the production of nitric oxide (NO), reactive oxygen species, interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha and enhanced the production of the inhibitory cytokine, IL-10, and additional neurotrophic factors, including nerve growth factor (NGF), glia-derived neurotrophic factor (GDNF), and neurotrophin (NT)-4 in activated microglia. ibudilast 28-37 interleukin 6 Homo sapiens 135-139 14578214-6 2004 The phosphoinositide 3-OH kinase inhibitor Ly294002 prevented nuclear translocation of NF-kappaB and the subsequent release of interleukin-6 and macrophage inflammatory protein-2alpha in overventilated but not in endotoxic lungs. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 43-51 interleukin 6 Homo sapiens 127-140 14615256-0 2003 Verapamil inhibits interleukin-6 and vascular endothelial growth factor production in primary cultures of keloid fibroblasts. Verapamil 0-9 interleukin 6 Homo sapiens 19-32 13679236-7 2003 Moxifloxacin inhibited the release of TNFalpha, IL-1, IL-6, and IL-8 in a concentration-dependent manner across a range of 0.004 to 4 microg/mL. Moxifloxacin 0-12 interleukin 6 Homo sapiens 54-58 12970036-10 2003 RESULTS: and measurements: EBC NO(2)(-) correlated well with VT (milliliters per kilogram of BW; r = 0.79, p < 0.0001) and expiratory minute volume (r = 0.60, p < 0.0001) but not with other ventilatory parameters or parameters of pulmonary (EBC IL-6, EBC IL-8) or systemic (serum IL-6, IL-8, and procalcitonin) inflammation. NSC638702 27-30 interleukin 6 Homo sapiens 251-255 12970036-10 2003 RESULTS: and measurements: EBC NO(2)(-) correlated well with VT (milliliters per kilogram of BW; r = 0.79, p < 0.0001) and expiratory minute volume (r = 0.60, p < 0.0001) but not with other ventilatory parameters or parameters of pulmonary (EBC IL-6, EBC IL-8) or systemic (serum IL-6, IL-8, and procalcitonin) inflammation. NSC638702 27-30 interleukin 6 Homo sapiens 286-290 12845688-5 2003 The combination of pamidronate with VAD-chemotherapy produced a reduction in TRACP-5b, NTX, IL-6, paraprotein and beta2-microglobulin levels from the 2nd month of treatment, with no effect on bone formation and OPG. Pamidronate 19-30 interleukin 6 Homo sapiens 92-96 14566081-0 2003 Poly-C specific ribonuclease activity correlates with increased concentrations of IL-6, IL-8 and sTNFR55/sTNFR75 in plasma of patients with acute pancreatitis. Poly C 0-6 interleukin 6 Homo sapiens 82-86 12887687-6 2003 It is suggested that CYP2E1, together with interleukin-6 and ciliary neurotrophic factor, is part of a response of astrocytes to cellular stress elicited by, e.g. cerebral injury, cytokines or phorbol ester, and mediated in part through protein kinase C. Phorbol Esters 193-206 interleukin 6 Homo sapiens 43-88 12720152-2 2003 Although its molecular mechanisms of action have not yet been elucidated, thalidomide and the IMiDs affect a variety of cytokines and inflammatory mediators including tumor necrosis factor-alpha (TNFalpha), interleukin (IL)-1beta, interferon gamma (IFNgamma), IL-6, IL-10, IL-12, and COX-2 and angiogenesis factors such as vascular endothelial growth factor (VEGF) and its receptor. Thalidomide 74-85 interleukin 6 Homo sapiens 260-264 12682431-0 2003 Induction of interleukin-6 by coal containing bioavailable iron is through both hydroxyl radical and ferryl species. Hydroxyl Radical 80-96 interleukin 6 Homo sapiens 13-26 12682431-10 2003 Our results indicate that BAI in the PA coal may induce IL-6 through both ferryl species (via iron autoxidation) and hydroxyl radicals (via the Fenton/Haber Weiss reactions). Hydroxyl Radical 117-134 interleukin 6 Homo sapiens 56-60 12393684-4 2002 In addition, either anti-interleukin 6 (anti-IL-6) or anti-IL-7 antibody inhibited HMCL-induced RANKL overexpression. hmcl 83-87 interleukin 6 Homo sapiens 45-49 12445202-7 2002 Use of the two phosphotidyl inositol 3-kinase inhibitors, LY294002 and wortmannin, to check whether this pathway is involved in Mcl-1 upregulation by interleukin-6, we found that the phosphotidyl inositol 3-kinase inhibitors completely attenuated the interleukin-6-induced Mcl-1 upregulation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 58-66 interleukin 6 Homo sapiens 150-163 12445202-7 2002 Use of the two phosphotidyl inositol 3-kinase inhibitors, LY294002 and wortmannin, to check whether this pathway is involved in Mcl-1 upregulation by interleukin-6, we found that the phosphotidyl inositol 3-kinase inhibitors completely attenuated the interleukin-6-induced Mcl-1 upregulation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 58-66 interleukin 6 Homo sapiens 251-264 12433058-2 2002 Inhibition of glutathione-oxidized disulfide reductase, which recycles GSSG --> 2GSH, by the action of 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) augmented LPS-dependent secretion of interleukin (IL)-1beta, IL-6 and tumor necrosis factor (TNF)-alpha. Glutathione Disulfide 71-78 interleukin 6 Homo sapiens 212-216 12215492-6 2002 On the other hand, PPAR-gamma ligands troglitazone, pioglitazone, and 15-deoxy-Delta(12,14)-prostaglandin J(2) inhibited IL-1beta-induced IL-6 expression at a transcriptional revel in VSMCs. delta 79-84 interleukin 6 Homo sapiens 138-142 12473263-4 2002 Paraformaldehyde (0.1% for 2min) or actinomycin-D (1 microg/ml for 24h) pre-treatment of the F-spheroids abolished the monocyte IL-6 co-culture response. paraform 0-16 interleukin 6 Homo sapiens 128-132 12473263-5 2002 Addition of glucose (100mM) or mannose (100mM), and to some extent galactose (100mM), but not fructose (100mM) to the co-cultures, partly inhibited the monocyte IL-6 co-culture response, but such addition did not inhibit the in vitro monocyte lipopolysaccharide (LPS)-generated IL-6 secretion. Mannose 31-38 interleukin 6 Homo sapiens 161-165 12473263-6 2002 When mannose was added to the co-cultures, monocyte IL-6 mRNA expression was eradicated in malignant co-cultures and reduced to a low level in benign co-cultures. Mannose 5-12 interleukin 6 Homo sapiens 52-56 12233891-7 2002 Percentage change in SUA at onset of attack correlated with CRP and IL-6 (r = 0.762, p < 0.0001; r = 0.630, p < 0.005), as well as with increased urinary excretion of uric acid, estimated by percentage change in fractional excretion of uric acid (FEua) during attack (r = 0.447, p < 0.05). sua 21-24 interleukin 6 Homo sapiens 68-72 12165085-7 2002 T-HPMC and P-HPMC constitutively expressed IL-6 and IL-8 at both protein and mRNA level. p-hpmc 11-17 interleukin 6 Homo sapiens 43-47 12080442-9 2002 The effects of dexamethasone and catecholamines on IL-6 and leptin were abrogated by RU486 and propranolol, respectively. Mifepristone 85-90 interleukin 6 Homo sapiens 51-55 12137744-4 2002 Secretion of IL-6 after VD was 2.3 +/- 0.47 (basal) and 3.01 +/- 0.34 (+1n M TNFalpha), was correlated with the secretion of IL-1beta and was more sensitive to TNFalpha dose after VD than CS. Cesium 188-190 interleukin 6 Homo sapiens 13-17 12027072-11 2002 CONCLUSIONS: These results indicate that azelastine and olopatadine can inhibit CHMCs activation and release of IL-6, tryptase, and histamine. Olopatadine Hydrochloride 56-67 interleukin 6 Homo sapiens 112-116 12010778-7 2002 8-Bromo cyclic AMP and dibutyryl cyclic AMP, cyclic AMP analogues, mimicked the effects of PGE(2) on IL-6, M-CSF, and VEGF production by OA fibroblasts. 8-Bromo Cyclic Adenosine Monophosphate 0-18 interleukin 6 Homo sapiens 101-105 11918718-0 2002 Eicosapentaenoic acid, a n-3 polyunsaturated fatty acid differentially modulates TNF-alpha, IL-1alpha, IL-6 and PGE2 expression in UVB-irradiated human keratinocytes. Fatty Acids, Omega-3 25-55 interleukin 6 Homo sapiens 103-107 11950021-10 2002 ACECLO, DICLO, INDO, NIM significantly inhibited basal and IL-1beta stimulated IL-6 production; CELE and IBUP only inhibited IL-1beta stimulated IL-6 production; and ROFE and PIROX had no significant effects. aceclofenac 0-6 interleukin 6 Homo sapiens 79-83 12090904-6 2002 The effects of fluvastatin on IL-6 expression were completely reversed in the presence of mevalonate or geranylgeranyl-pyrophosphate, but not squalene. geranylgeranyl pyrophosphate 104-132 interleukin 6 Homo sapiens 30-34 12122578-12 2002 Although both CPZ and amiloride significantly reduced IL-6 release for all PM, the degree of inhibition was less for the PM-exposed DRG relative to BEAS-2B cells. Amiloride 22-31 interleukin 6 Homo sapiens 54-58 12476615-2 2002 Our study was designed to determine whether heat shock and drugs like cisplatin, etoposide and quercetin influence the expression of heat shock protein 72 in tumour cells: HeLa (cervical cancer), Hep-2 (larynx cancer), A549 (lung cancer) and normal human skin fibroblasts (HSF). Etoposide 81-90 interleukin 6 Homo sapiens 273-276 11753617-13 2001 Finally, thalidomide (100 microM) and its immunomodulatory analog IMiD1-CC4047 (1 microM) decreased the upregulation of IL-6 and VEGF secretion in cultures of BMSCs, MM cells and co-cultures of BMSCs with MM cells. Thalidomide 9-20 interleukin 6 Homo sapiens 120-124 16134523-0 2001 [Regulatory effects of mifepristone and progesterone on the secretion of interleukin-6 by cultured eutopic and etopic endometrial cells]. Mifepristone 23-35 interleukin 6 Homo sapiens 73-86 16134523-1 2001 OBJECTIVE: To investigate the regulatory effects of mifepristone and progesterone on the secretion of interleukin-6 (IL-6) by endometrial and endometriosis cells in vitro. Mifepristone 52-64 interleukin 6 Homo sapiens 102-115 16134523-1 2001 OBJECTIVE: To investigate the regulatory effects of mifepristone and progesterone on the secretion of interleukin-6 (IL-6) by endometrial and endometriosis cells in vitro. Mifepristone 52-64 interleukin 6 Homo sapiens 117-121 16134523-4 2001 RESULTS: Mifepristone inhibited the IL-6 secretion of ectopic endometrial cells, with the concentrations of IL-6 was (1 914.33 +/- 799.28) microg/L in the 1 x 10(-6) mol/L group (P < 0.01) and (990.25 +/- 58.40) microg/L in the 10(-4) mol/L group (P < 0.01). Mifepristone 9-21 interleukin 6 Homo sapiens 36-40 16134523-4 2001 RESULTS: Mifepristone inhibited the IL-6 secretion of ectopic endometrial cells, with the concentrations of IL-6 was (1 914.33 +/- 799.28) microg/L in the 1 x 10(-6) mol/L group (P < 0.01) and (990.25 +/- 58.40) microg/L in the 10(-4) mol/L group (P < 0.01). Mifepristone 9-21 interleukin 6 Homo sapiens 108-112 16134523-6 2001 Mifepristone restrained the secretion of IL-6 by eutopic endometrial cells, with (346.96 < or = 24.32) microg/L in the 1 x 10(-6) mol/L group (P < 0.01) and (270.22 +/- 36.15) microg/L in the 1 x 10(-4) mol/L group (P < 0.01). Mifepristone 0-12 interleukin 6 Homo sapiens 41-45 16134523-9 2001 CONCLUSION: The inhibitory effects on the secretion of IL-6 by ectopic and (or) eutopic endometrium may provide one of the cellular therapeutic mechanisms of mifepristone and progesterone on endometriosis. Mifepristone 158-170 interleukin 6 Homo sapiens 55-59 11593385-8 2001 Meanwhile, the IL-6-induced Mcl-1 up-regulation was effectively abolished by treatment with PI 3-K inhibitors, LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 111-119 interleukin 6 Homo sapiens 15-19 11426023-2 2001 METHODS: Levels of circulating IL-6 protein and polymorphism of the IL6 gene were analysed in 66 patients with pSS and in 400 healthy subjects. pss 111-114 interleukin 6 Homo sapiens 31-35 11426023-2 2001 METHODS: Levels of circulating IL-6 protein and polymorphism of the IL6 gene were analysed in 66 patients with pSS and in 400 healthy subjects. pss 111-114 interleukin 6 Homo sapiens 68-71 11426023-4 2001 RESULTS: Plasma IL-6 was elevated in pSS patients compared with healthy controls. pss 37-40 interleukin 6 Homo sapiens 16-20 11575340-10 2001 Interleukin 6 decreased in the dexmedetomidine group. Dexmedetomidine 31-46 interleukin 6 Homo sapiens 0-13 11683535-6 2001 The addition of pamidronate to maintenance treatment resulted in a significant reduction of NTx, IL-6, beta2-microglobulin, CRP from the 3rd month and paraprotein from the 6th month of treatment, whereas BAP and OSC were significantly increased from the 6th month. Pamidronate 16-27 interleukin 6 Homo sapiens 97-101 11299072-8 2001 The polyunsaturated fatty acids (PUFA) include the n-3 compounds, some of which are precursors of eicosanoid synthesis, and the n-6 group which can increase formation of the pro-inflammatory cytokines TNFalpha and interleukin-6, and of reactive oxygen species. Fatty Acids, Unsaturated 4-31 interleukin 6 Homo sapiens 214-227 11299072-8 2001 The polyunsaturated fatty acids (PUFA) include the n-3 compounds, some of which are precursors of eicosanoid synthesis, and the n-6 group which can increase formation of the pro-inflammatory cytokines TNFalpha and interleukin-6, and of reactive oxygen species. Fatty Acids, Unsaturated 33-37 interleukin 6 Homo sapiens 214-227 11332630-3 2001 Furthermore, GC inhibition of IL-6-stimulated B9 cell proliferation was receptor mediated and was abrogated by the GC receptor antagonist, RU486. Mifepristone 139-144 interleukin 6 Homo sapiens 30-34 11314001-9 2001 However, the IL-6-induced Mcl-1 up-regulation was effectively attenuated in the presence of PI 3-K inhibitors, LY294002 and wortmannin. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 111-119 interleukin 6 Homo sapiens 13-17 11471549-9 2001 Silica induced a little IL-6 secretion, without affecting IL-1 and TGFbeta isoform production and strongly stimulated bFGF mRNA level and bFGF protein secretion. Silicon Dioxide 0-6 interleukin 6 Homo sapiens 24-28 11133502-7 2001 8-Bromo-cAMP treatment resulted in dose-related increases in IL-6 release. 8-Bromo Cyclic Adenosine Monophosphate 0-12 interleukin 6 Homo sapiens 61-65 11165942-3 2001 In addition, the stimulation of IL-6 release was also reduced by pyrrolidine dithiocarbamate (PDTC) or NF-kappaB SN50, which has been reported to be a potent NF-kappaB inhibitor. pyrrolidine dithiocarbamic acid 65-92 interleukin 6 Homo sapiens 32-36 11165942-3 2001 In addition, the stimulation of IL-6 release was also reduced by pyrrolidine dithiocarbamate (PDTC) or NF-kappaB SN50, which has been reported to be a potent NF-kappaB inhibitor. pyrrolidine dithiocarbamic acid 94-98 interleukin 6 Homo sapiens 32-36 11403239-8 2001 A positive correlation was found between the concentration of IL-6 and the contents of benzoylperoxide (p = 0.0003) and barium sulphate (p < 0.0001). Benzoyl Peroxide 87-102 interleukin 6 Homo sapiens 62-66 12094620-7 2001 In addition, interleukin-6 synthesis by these two cell lines was inhibited by genistein or daidzein; production was decreased by approximately 20% compared with the control group (P < 0.05). Genistein 78-87 interleukin 6 Homo sapiens 13-26 11118064-6 2000 Inhibition of PI 3-K activity with wortmannin or Ly294002 blocked the antiapoptotic effect of IGF-I and the proliferative effect of IL-6 in the myeloma cell lines. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 49-57 interleukin 6 Homo sapiens 132-136 11092464-5 2000 RESULTS: The addition of pamidronate to chemotherapy resulted in a significant reduction of NTx, IL-6 and paraprotein from the 3rd month and of beta2-microglobulin, CRP and pain from the 6th month of treatment. Pamidronate 25-36 interleukin 6 Homo sapiens 97-101 11106000-2 2000 Sophoricoside, genistein and orobol exhibited inhibitory effects on IL-5, IL-3, GM-CSF and IL-6 bioactivities. sophoricoside 0-13 interleukin 6 Homo sapiens 91-95 11106000-2 2000 Sophoricoside, genistein and orobol exhibited inhibitory effects on IL-5, IL-3, GM-CSF and IL-6 bioactivities. Genistein 15-24 interleukin 6 Homo sapiens 91-95 11001908-7 2000 PEL cells treated with Bay 11 demonstrated down-regulation of the NF-kappaB inducible cytokine interleukin 6 (IL-6), and apoptosis. bay 11 23-29 interleukin 6 Homo sapiens 95-108 11001908-7 2000 PEL cells treated with Bay 11 demonstrated down-regulation of the NF-kappaB inducible cytokine interleukin 6 (IL-6), and apoptosis. bay 11 23-29 interleukin 6 Homo sapiens 110-114 10884313-4 2000 Pretreatment of astrocytes with P2 receptor antagonists, including suramin and periodate oxidized ATP (oATP), resulted in a significant downregulation of IL-1beta-stimulated expression of nitric oxide, tumor necrosis factor (TNFalpha), and IL-6 at both the protein and mRNA levels, without affecting cell viability. metaperiodate 79-88 interleukin 6 Homo sapiens 240-244 10949106-0 2000 Interleukin-6 and tumor necrosis factor-alpha production after acute psychological stress, exercise, and infused isoproterenol: differential effects and pathways. Isoproterenol 113-126 interleukin 6 Homo sapiens 0-45 11789240-0 2000 [Effect of Tripterygium polyglycoside on interleukin-6 in patients with Guillain-Barre syndrome]. tripterygium polyglycoside 11-37 interleukin 6 Homo sapiens 41-54 11229609-9 2000 Exposure of HPMCs to conventional PDF resulted in a significant reduction in IL-6 release, which was fully restored following exposure to Stay-Safe Balance. hpmcs 12-17 interleukin 6 Homo sapiens 77-81 10408408-0 1999 Expression and up-regulation of interleukin-6 in oesophageal carcinoma cells by n-sodium butyrate. n-sodium butyrate 80-97 interleukin 6 Homo sapiens 32-45 10408408-9 1999 Up-regulation of IL-6 by n-sodium butyrate (n-BT) was studied in ESCC cell lines. n-sodium butyrate 25-42 interleukin 6 Homo sapiens 17-21 10328874-4 1999 In addition, sodium salicylate and additional NSAIDs used at concentrations that activate HSF1 also inhibited the expression of other monocytic genes (TNF-alpha, IL-1beta, IL-6, IL-8, IL-10, ICAM-1) activated by exposure to a pro-inflammatory stimulus (lipopolysaccharide, LPS). Sodium Salicylate 13-30 interleukin 6 Homo sapiens 172-176 10382942-4 1999 The addition of IL-6 or both IL-6 and MGF to M-CSF containing cultures resulted in significant higher numbers of colony-forming unit-macrophage (CFU-M) as tested in clonogenic and 3H-thymidine assays. Thymidine 183-192 interleukin 6 Homo sapiens 16-20 10382942-4 1999 The addition of IL-6 or both IL-6 and MGF to M-CSF containing cultures resulted in significant higher numbers of colony-forming unit-macrophage (CFU-M) as tested in clonogenic and 3H-thymidine assays. Thymidine 183-192 interleukin 6 Homo sapiens 29-33 9987074-7 1999 RESULTS: We found that calcitriol and paricalcitol behaved in a similar fashion, resulting in increased IL-6 release only at higher concentrations (10(-7) to 10(-9) M). paricalcitol 38-50 interleukin 6 Homo sapiens 104-108 10096130-1 1999 This project focused on the effects of aflatoxin B1 (AFB1), a food-contaminating mycotoxin produced by fungi, genus Aspergillus, on the release and genetic expression of some important cytokines, i.e., (interleukin-1 alpha (IL-1 alpha), IL-6, tumor necrosis factor-alpha (TNF alpha)) by human monocytes. Aflatoxin B1 39-51 interleukin 6 Homo sapiens 237-241 10096130-1 1999 This project focused on the effects of aflatoxin B1 (AFB1), a food-contaminating mycotoxin produced by fungi, genus Aspergillus, on the release and genetic expression of some important cytokines, i.e., (interleukin-1 alpha (IL-1 alpha), IL-6, tumor necrosis factor-alpha (TNF alpha)) by human monocytes. Aflatoxin B1 53-57 interleukin 6 Homo sapiens 237-241 10096130-4 1999 Pretreatment of monocytes with AFB1 resulted in a decrease in IL-1, IL-6 and TNF alpha release already at a concentration of 0.05 pg/mL. Aflatoxin B1 31-35 interleukin 6 Homo sapiens 68-72 10096130-6 1999 In fact, AFB1 completely blocked the transcription of IL-1 alpha, IL-6 and TNF alpha mRNAs, while it did not affect beta-actin mRNA at the concentrations used. Aflatoxin B1 9-13 interleukin 6 Homo sapiens 66-70 9934491-2 1998 Truncated analogs of tripterine as cytokine (IL-1 alpha, IL-1 beta, TNF-alpha, IL-6, and IL-8) release inhibitors are discussed. celastrol 21-31 interleukin 6 Homo sapiens 79-83 9876100-2 1998 Inflammatory cytokines such as interleukin (IL)-1, IL-6, and tumor necrosis factor alpha (TNFalpha) are related to the development of DRA. dra 134-137 interleukin 6 Homo sapiens 51-55 9891467-3 1998 However, IL-6 production is increased in proportion to the increasing thymidine labelling index in benign or malignant tissues (r = 0.94, r = 0.76). Thymidine 70-79 interleukin 6 Homo sapiens 9-13 9840004-8 1998 Increased IL-6 levels were observed in cultures exposed to copper (5-19-fold compared to untreated controls), zinc (16-fold), cobalt (12-fold), nickel (10-fold) and palladium (4-fold). Cobalt 126-132 interleukin 6 Homo sapiens 10-14 9776474-6 1998 Analysis of supernatants by enzyme-linked immunosorbent assay (ELISA) showed that thalidomide caused a dose-dependent inhibition of the pro-inflammatory cytokines interleukin 6 (IL-6) and tumour necrosis factor alpha (TNF-alpha), maximally reducing production by 20 (P < 0.05) and 30% (P < 0.01), respectively, compared with controls. Thalidomide 82-93 interleukin 6 Homo sapiens 163-176 9776474-6 1998 Analysis of supernatants by enzyme-linked immunosorbent assay (ELISA) showed that thalidomide caused a dose-dependent inhibition of the pro-inflammatory cytokines interleukin 6 (IL-6) and tumour necrosis factor alpha (TNF-alpha), maximally reducing production by 20 (P < 0.05) and 30% (P < 0.01), respectively, compared with controls. Thalidomide 82-93 interleukin 6 Homo sapiens 178-182 9776474-10 1998 Reverse transcription-polymerase chain reaction (RT-PCR) analyses showed that thalidomide inhibited selectively the expression of TNF-alpha and IL-6 mRNA, whereas dexamethasone inhibited mRNA levels of all cytokines examined. Thalidomide 78-89 interleukin 6 Homo sapiens 144-148 9776474-12 1998 Conversely, thalidomide selectively inhibits the production of IL-6 and TNF-alpha. Thalidomide 12-23 interleukin 6 Homo sapiens 63-67 9647240-4 1998 The maintenance of IL-6-induced STAT-masking was dependent on continued signaling through the phosphatidylinositol-dependent phospholipase C pathway. Phosphatidylinositols 94-114 interleukin 6 Homo sapiens 19-23 9657261-3 1998 Okadaic acid, an inhibitor of protein phosphatase 1 and 2A, affected IL-6-induced p140 phosphorylation. Okadaic Acid 0-12 interleukin 6 Homo sapiens 69-73 9657261-5 1998 When IRF-1 promoter-luciferase construct was transfected into Hep3B cells, okadaic acid increased IL-6- induced IRF-1 promoter activity. Okadaic Acid 75-87 interleukin 6 Homo sapiens 98-102 9512898-3 1998 Interleukin 6 (IL-6) and IL-8 production in response to PMA were markedly diminished by the PKC inhibitor staurosporine. Staurosporine 106-119 interleukin 6 Homo sapiens 0-13 9512898-3 1998 Interleukin 6 (IL-6) and IL-8 production in response to PMA were markedly diminished by the PKC inhibitor staurosporine. Staurosporine 106-119 interleukin 6 Homo sapiens 15-19 9575555-2 1998 Here we show that inhibitors of ADP-ribosylation namely nicotinamide and meta-iodobenzylguanidine prevent production of TNF-alpha and IL-6 at the protein and mRNA level. 3-Iodobenzylguanidine 73-97 interleukin 6 Homo sapiens 134-138 9466128-2 1997 Reductions in the production of pro-inflammatory cytokines interleukin 1 beta (IL-1 beta), tumour necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6) have been seen in humans after short-term n-3 fatty acid supplementation. Fatty Acids, Omega-3 200-214 interleukin 6 Homo sapiens 152-156 9351880-16 1997 In vitro, an increase in TNF alpha and a mild increase in IL-6 was seen with all bisphosphonates, with the greatest effects seen with the highest concentration of both pamidronate and zoledronate. Pamidronate 168-179 interleukin 6 Homo sapiens 58-62 9351880-18 1997 Significant changes in both TNF alpha and IL-6 were observed within 3 days of a single dose of pamidronate in patients treated for the first time confirming previous findings. Pamidronate 95-106 interleukin 6 Homo sapiens 42-46 9378980-3 1997 IL-6 induction was dependent on the intracellular redox-oxidative state, since intracellular hydroxyl scavengers and N-acetylcysteine, a precursor of glutathione, abrogated IL-6 secretion by asbestos or H2O2. Hydroxyl Radical 93-101 interleukin 6 Homo sapiens 0-4 9378980-3 1997 IL-6 induction was dependent on the intracellular redox-oxidative state, since intracellular hydroxyl scavengers and N-acetylcysteine, a precursor of glutathione, abrogated IL-6 secretion by asbestos or H2O2. Hydroxyl Radical 93-101 interleukin 6 Homo sapiens 173-177 9378980-6 1997 Stimulation of DNA binding activity to the NF-kappa B and NF-IL-6 binding sites of the IL-6 promoter by asbestos or H2O2 were inhibited by tetramethylthiourea, a hydroxyl radical scavenger. Hydroxyl Radical 162-170 interleukin 6 Homo sapiens 61-65 18636446-5 1997 Antisense oligodeoxynucleotides complementary to the mRNA encoding gp 130 inhibited the upregulation of haptoglobin by IL-6-stimulated HepG2 cells by about 50%. Oligodeoxyribonucleotides 10-31 interleukin 6 Homo sapiens 119-123 9169790-2 1997 Their potencies in stimulating IL-6 release were mannoproteins > galactoxylomannan = glucuronoxylomannan > alpha(1-3)glucan. galactoxylomannan 68-85 interleukin 6 Homo sapiens 31-35 9169790-2 1997 Their potencies in stimulating IL-6 release were mannoproteins > galactoxylomannan = glucuronoxylomannan > alpha(1-3)glucan. glucuronoxylomannan 88-107 interleukin 6 Homo sapiens 31-35 9141914-6 1997 Postoperative increases in IL-6 were smallest in patients who received 2.0 micrograms.kg-1.min-1 dopexamine (P < or = 0.02). dopexamine 97-107 interleukin 6 Homo sapiens 27-31 9179627-8 1997 The temporal expression of TNF, IL-1, IL-6 and NO suggest a cascade of inflammatory mediators in which monocytes and macrophages respond to PG/PS with enhanced synthesis of TNF and IL-1, which may in turn promote the synthesis of IL-6 and NO. Phosphorus 143-145 interleukin 6 Homo sapiens 38-42 9179627-8 1997 The temporal expression of TNF, IL-1, IL-6 and NO suggest a cascade of inflammatory mediators in which monocytes and macrophages respond to PG/PS with enhanced synthesis of TNF and IL-1, which may in turn promote the synthesis of IL-6 and NO. Phosphorus 143-145 interleukin 6 Homo sapiens 230-234 9367289-6 1997 The serum IL-6 were related to SaO2, (r = -0.45, p = 0.003), but not to heart rates or AMS scores. sao2 31-35 interleukin 6 Homo sapiens 10-14 9459494-4 1997 Furthermore, it is shown that NiCl2 induces mRNA expression of E-selectin, intercellular adhesion molecule-1, IL-6 and IL-8 in a 1-mM concentration. nickel chloride 30-35 interleukin 6 Homo sapiens 110-114 8943271-4 1996 A construct (HSFDT385SH) of the heat shock transcription factor (HSF) was expressed that contains the DNA-binding and trimerization domains, residues 192-385 of HSF, with four additional COOH-terminal residues, GMLC, and then labeled at the COOH-terminal cysteine with fluorescein 5-maleimide to form HSFDT385-Fl. gmlc 211-215 interleukin 6 Homo sapiens 32-63 8943271-4 1996 A construct (HSFDT385SH) of the heat shock transcription factor (HSF) was expressed that contains the DNA-binding and trimerization domains, residues 192-385 of HSF, with four additional COOH-terminal residues, GMLC, and then labeled at the COOH-terminal cysteine with fluorescein 5-maleimide to form HSFDT385-Fl. gmlc 211-215 interleukin 6 Homo sapiens 65-68 8920958-4 1996 The maximal IL-6-induced increase in IGFBP-1 was comparable to that observed with dexamethasone, and this increase was attenuated by diltiazem or dantrolene, both of which are known to reduce the cytosolic Ca2+ concentration. Dantrolene 146-156 interleukin 6 Homo sapiens 12-16 9074108-4 1996 The IL-6 concentrations, as a percentage of preoperative level, were significantly elevated postoperatively in both groups, and also perioperatively in the LH group. Luteinizing Hormone 156-158 interleukin 6 Homo sapiens 4-8 8768869-4 1996 Among the various cytokines, IL-6, GH, and insulin-like growth factor I (IGF-I) also enhanced Ig production and thymidine uptake in plasma cells. Thymidine 112-121 interleukin 6 Homo sapiens 29-33 8660820-4 1996 When human monocytes/macrophages stimulated with silica were treated with 0.1-10 microg/ml acanthoic acid, the production of IL-1 and TNF-alpha was inhibited up to 90%, but the production of interleukin-6 (IL-6) was not inhibited at all. Silicon Dioxide 49-55 interleukin 6 Homo sapiens 191-204 8660820-4 1996 When human monocytes/macrophages stimulated with silica were treated with 0.1-10 microg/ml acanthoic acid, the production of IL-1 and TNF-alpha was inhibited up to 90%, but the production of interleukin-6 (IL-6) was not inhibited at all. Silicon Dioxide 49-55 interleukin 6 Homo sapiens 206-210 8888356-7 1996 Similarly, a significant inhibitory effect by n-3 PUFA treatment on basal and LPS-stimulated IL-6 monocyte production was observed (50% and 46%, respectively, P < 0.05). Fatty Acids, Unsaturated 50-54 interleukin 6 Homo sapiens 93-97 8833207-4 1996 Moreover, pamidronate was found to slightly stimulate interleukin-6 IL-6 production. Pamidronate 10-21 interleukin 6 Homo sapiens 54-72 8833207-9 1996 Plasma IL-6 and TNFalpha levels increased significantly after pamidronate treatment, whereas no change was seen after clodronate infusion. Pamidronate 62-73 interleukin 6 Homo sapiens 7-11 8833207-13 1996 Patients treated with pamidronate, whose body temperatures were increased at 24 h, had a greater increases of circulating IL-6, TNFalpha, and CRP at 24 h and 48 h than patients without temperature increase. Pamidronate 22-33 interleukin 6 Homo sapiens 122-126 8833207-14 1996 These results suggest that pamidronate treatment, but not clodronate and possibly not ibandronate at the doses used, induced an increase in the plasma levels of IL-6 and TNFalpha, which may be responsible for the acute phase reaction observed clinically. Pamidronate 27-38 interleukin 6 Homo sapiens 161-165 8815590-3 1996 Echinomycin also reduced LPS-induced secretion of IL-1 beta and IL-6 by human PBMC (IC50 = 10 +/- 2 and 3 +/- 0.5 nM respectively). Echinomycin 0-11 interleukin 6 Homo sapiens 64-68 8556709-4 1996 We observed that the activated Raf significantly potentiated the induction of MDRCAT activity in GHE-L cells by sodium arsenite or heat shock, which stimulates heat shock factor (HSF) binding to HSE. sodium arsenite 112-127 interleukin 6 Homo sapiens 179-182 8550757-5 1996 Involvement of the glucocorticoid receptor in this response was supported by abrogation of Dex (10(-7) mol/L) inhibition of IL-6 production by the glucocorticoid receptor antagonist RU 38486. Mifepristone 182-190 interleukin 6 Homo sapiens 124-128 7757989-10 1995 By analyzing the molecular mechanisms of IL-6 up-regulation upon PDT, we provide evidence for regulatory differences compared to UV light, ionizing irradiation, or stimulation by phorbol ester. Phorbol Esters 179-192 interleukin 6 Homo sapiens 41-45 7539384-9 1995 IL-3 induced IL-6 secretion in these cells, which was augmented by a protein kinase-C (PKC) inhibitor, H7, and reduced by a tyrosine kinase inhibitor, genistein. Genistein 151-160 interleukin 6 Homo sapiens 13-17 7704910-5 1995 A cAMP analog (dibutyryl cAMP), a stimulator of adenyl cyclase (forskolin), and phosphodiesterase inhibitors (aminophylline and IBMX) which inhibited the 446-BCDF-induced decrease in intracellular cAMP, inhibited 446-BCDF-induced B cell differentiation, suggesting that the fall in intracellular cAMP was a critical event in this process. 1-Methyl-3-isobutylxanthine 128-132 interleukin 6 Homo sapiens 158-162 7704910-5 1995 A cAMP analog (dibutyryl cAMP), a stimulator of adenyl cyclase (forskolin), and phosphodiesterase inhibitors (aminophylline and IBMX) which inhibited the 446-BCDF-induced decrease in intracellular cAMP, inhibited 446-BCDF-induced B cell differentiation, suggesting that the fall in intracellular cAMP was a critical event in this process. 1-Methyl-3-isobutylxanthine 128-132 interleukin 6 Homo sapiens 217-221 7640347-0 1995 Interleukin 6 production by lipopolysaccharide-stimulated human fibroblasts is potently inhibited by naphthoquinone (vitamin K) compounds. Naphthoquinones 101-115 interleukin 6 Homo sapiens 0-13 7640347-4 1995 Fibroblasts are now recognized as a rich source of cytokines and we have examined the effect of various naphthoquinones on the production of interleukin 6 (IL-6) by lipopolysaccharide-stimulated human gingival fibroblasts. Naphthoquinones 104-119 interleukin 6 Homo sapiens 141-154 7640347-4 1995 Fibroblasts are now recognized as a rich source of cytokines and we have examined the effect of various naphthoquinones on the production of interleukin 6 (IL-6) by lipopolysaccharide-stimulated human gingival fibroblasts. Naphthoquinones 104-119 interleukin 6 Homo sapiens 156-160 7740525-0 1995 Effect of long-term, moderate-dose supplementation with omega-3 fatty acids on monocyte procoagulant activity and release of interleukin-6 in patients with coronary artery disease. Fatty Acids, Omega-3 56-75 interleukin 6 Homo sapiens 125-138 7497600-2 1995 R-verapamil caused a dose-dependent inhibition of AML blast proliferation in the presence of stem-cell factor, leukemia inhibitory factor, interleukin 4, interleukin 6, and interleukin 10 when these cytokines were tested both alone and in different combinations. Verapamil 0-11 interleukin 6 Homo sapiens 154-167 7957581-4 1994 However, the enhancement of plasma cell responses by GM1 was specific and was not mediated by IL-6, since GM1 activity was blocked by anti-GM1 monoclonal antibody (mAb), but not by control IgM, anti-IL-6 Ab or the anti-IL-6 receptor mAb, PM1. G(M1) Ganglioside 53-56 interleukin 6 Homo sapiens 199-203 7957581-4 1994 However, the enhancement of plasma cell responses by GM1 was specific and was not mediated by IL-6, since GM1 activity was blocked by anti-GM1 monoclonal antibody (mAb), but not by control IgM, anti-IL-6 Ab or the anti-IL-6 receptor mAb, PM1. G(M1) Ganglioside 53-56 interleukin 6 Homo sapiens 199-203 7919342-6 1994 c-Jun antisense, but not sense, oligodeoxynucleotide (ODN) significantly decreases PWM-related B-cell (1) proliferation; (2) IL-6 mRNA induction; (3) IL-6 secretion; and (4) nuclear extract binding to AP-1 in electrophoretic mobility shift assay. Oligodeoxyribonucleotides 54-57 interleukin 6 Homo sapiens 125-129 7947352-5 1994 Specifically, RU486 (at concentrations of 1-100 nM) exerts pure antagonist actions by almost completely reversing the inhibitory effects of the glucocorticoid dexamethasone (Dex) on the release of monocyte/macrophages-derived lymphokines, such as IL-1, IL-6, IL-8 and tumor necrosis factor-alpha (TNF-alpha). Mifepristone 14-19 interleukin 6 Homo sapiens 253-257 7822688-0 1994 Nickel hydroxy carbonate increases tumour necrosis factor alpha and interleukin 6 secretion by alveolar macrophages. nickel hydroxycarbonate 0-24 interleukin 6 Homo sapiens 68-81 7822688-1 1994 The aim of the current study was to assess the in vitro effects of nickel hydroxy carbonate (NiHC) at noncytotoxic concentrations on the production of cytokines such as tumour necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) in alveolar macrophages (AMs). nickel hydroxycarbonate 67-91 interleukin 6 Homo sapiens 214-227 7822688-1 1994 The aim of the current study was to assess the in vitro effects of nickel hydroxy carbonate (NiHC) at noncytotoxic concentrations on the production of cytokines such as tumour necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) in alveolar macrophages (AMs). nickel hydroxycarbonate 67-91 interleukin 6 Homo sapiens 229-233 7822688-1 1994 The aim of the current study was to assess the in vitro effects of nickel hydroxy carbonate (NiHC) at noncytotoxic concentrations on the production of cytokines such as tumour necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) in alveolar macrophages (AMs). nickel hydroxycarbonate 93-97 interleukin 6 Homo sapiens 214-227 7822688-1 1994 The aim of the current study was to assess the in vitro effects of nickel hydroxy carbonate (NiHC) at noncytotoxic concentrations on the production of cytokines such as tumour necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) in alveolar macrophages (AMs). nickel hydroxycarbonate 93-97 interleukin 6 Homo sapiens 229-233 7800135-7 1994 In addition, [3H]thymidine uptake was inhibited by a specific polyclonal antibody against IL-6. Thymidine 17-26 interleukin 6 Homo sapiens 90-94 8089051-0 1994 The release of TNF-alpha and IL-6 from human monocytes stimulated by filtrates of Candida albicans after treatment with amphotericin B. Amphotericin B 120-134 interleukin 6 Homo sapiens 29-33 8167153-3 1994 Inhibition of the response to IL-6 by cycloheximide and alpha-amanitin indicates that increases in PAI-1 are dependent on both protein and RNA synthesis. Alpha-Amanitin 56-70 interleukin 6 Homo sapiens 30-34 8187058-3 1994 When the administration of mitomycin C or cisplatin decreased the platelet number as a side reaction with a concomitant of suppressing the growth of colon 26 and LLC, respectively, hIL-6 could also increase the platelet count without the augmentation of tumor growth. Mitomycin 27-38 interleukin 6 Homo sapiens 181-186 8042536-8 1994 Moreover, DCDF significantly enhanced IL-1 beta and IL-6 production by monocytes in a dose-dependent manner. dcdf 10-14 interleukin 6 Homo sapiens 52-56 7509842-8 1994 Addition of salbutamol, inactive alone, potentiated the generation of superoxide anion and of nitric oxide generation, as well as the production of IL-6 and TxB2 triggered by CD23 ligation. Albuterol 12-22 interleukin 6 Homo sapiens 148-152 8258686-4 1993 Our study demonstrated that IL-2, IL-4, and IL-6-stimulation of IgM secretion by SKW6.4 cells was inhibited by either the serine/threonine kinase inhibitor, 1-(5-isoquinolinesulfonyl)-2-methylpiperizine dihydrochloride (H7) or the tyrosine kinase inhibitor, genistein. Genistein 258-267 interleukin 6 Homo sapiens 44-48 8186370-6 1993 Using digoxigenin-labelled oligonucleotide probes we have detected expression of the cytokines IL-1 alpha, IL-2, IL-4, IL-6, IL-10, IFN-gamma, TGF beta 1 & 2 and TNF-alpha in frozen sections of CNS tissue from MS cases. Digoxigenin 6-17 interleukin 6 Homo sapiens 119-123 8286511-8 1993 When palmitate uniformly labelled with 14C was used as the radiolabelled precursor, TNF-alpha stimulated the synthesis of both triacylglycerol and phosphatidylcholine, neither of which was affected by IL-1 or IL-6. Palmitates 5-14 interleukin 6 Homo sapiens 209-213 8309727-3 1993 The authors reported here the effects of antibiotics which penetrate inside the cells, such as quinolones and macrolides, on the capacity of blood monocytes to produce IL-I alpha, IL-1 beta, TNF alpha and IL-6 in response to endotoxin. Quinolones 95-105 interleukin 6 Homo sapiens 205-209 8309727-3 1993 The authors reported here the effects of antibiotics which penetrate inside the cells, such as quinolones and macrolides, on the capacity of blood monocytes to produce IL-I alpha, IL-1 beta, TNF alpha and IL-6 in response to endotoxin. Macrolides 110-120 interleukin 6 Homo sapiens 205-209 8309727-4 1993 Antibiotics can exert a differential effect on cytokine production: in fact, quinolones, in vitro, at concentrations higher than 25 micrograms/ml decreased IL-1 beta, TNF alpha and IL-6, while they do not modify IL-1 alpha. Quinolones 77-87 interleukin 6 Homo sapiens 181-185 8309727-7 1993 Among the same family of antibiotics such as macrolides, differences on cytokine modulation were observed: spiramycin and erythromycin increased IL-6 production while roxithromycin did not exert any significant effect. Macrolides 45-55 interleukin 6 Homo sapiens 145-149 8355691-5 1993 HSF activation in response to treatment with sodium arsenite or the proline analog azetidine was also depressed in hsp70-expressing cells relative to that in the nontransfected control cells. sodium arsenite 45-60 interleukin 6 Homo sapiens 0-3 7691769-3 1993 In vivo lentinan administration elicited an increase in IL-6 generation by monocytes in 3 of 5 cases. Lentinan 8-16 interleukin 6 Homo sapiens 56-60 8096406-6 1993 Furthermore, LIF and IL-6 RNA expression in an HTLV-I-infected cell line (MT-2) was enhanced by phorbol ester stimulation via mechanisms that appear to be dependent on the posttranscriptional regulatory controls. Phorbol Esters 96-109 interleukin 6 Homo sapiens 21-25 8392490-12 1993 The fact that two such agents, RU38486 and IL-1 have similar effects regarding their kinetics and their capacity to sensitize for the lethality- and IL-6-inducing effect of hTNF may give a hint regarding the mechanism of the sensitizing effect. Mifepristone 31-38 interleukin 6 Homo sapiens 149-153 8495969-1 1993 Escherichia coli bacteria expressing mannose-resistant fimbriae/haemagglutination induced the production of substantial amounts of tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) from a peripheral human lymphocyte, monocyte, basophil (LMB) cell suspension. Mannose 37-44 interleukin 6 Homo sapiens 176-189 8495969-1 1993 Escherichia coli bacteria expressing mannose-resistant fimbriae/haemagglutination induced the production of substantial amounts of tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) from a peripheral human lymphocyte, monocyte, basophil (LMB) cell suspension. Mannose 37-44 interleukin 6 Homo sapiens 191-195 8495969-2 1993 In this regard, E. coli bacteria with S-mannose-resistant fimbriae/haemagglutination were the most potent inducers of IL-6 and TNF-alpha secretion, followed by the E. coli strain with P-mannose-resistant fimbriae/haemagglutination. Mannose 40-47 interleukin 6 Homo sapiens 118-122 8464927-2 1993 Our studies on the response of rodent cells to heat shock or sodium arsenite indicate that a high level of HSF-DNA-binding activity, by itself, is not sufficient for the induction of hsp70 mRNA synthesis; furthermore, a high level of HSF binding is also not necessary for this induction. sodium arsenite 61-76 interleukin 6 Homo sapiens 107-110 8440709-7 1993 Exposure of HepG2 cells to phorbol 12-myristate 13-acetate (PMA) or PMA-dexamethasone led to an increase in the 80-kDa IL-6 receptor mRNA and functional receptor protein. pma-dexamethasone 68-85 interleukin 6 Homo sapiens 119-123 8440709-10 1993 Evidence is presented that the 80-kDa IL-6 receptor up-regulation by PMA-dexamethasone is caused by the depletion of protein kinase C since the protein kinase C inhibitor staurosporine mimics the effect of PMA-dexamethasone. Staurosporine 171-184 interleukin 6 Homo sapiens 38-42 8440709-10 1993 Evidence is presented that the 80-kDa IL-6 receptor up-regulation by PMA-dexamethasone is caused by the depletion of protein kinase C since the protein kinase C inhibitor staurosporine mimics the effect of PMA-dexamethasone. pma-dexamethasone 69-86 interleukin 6 Homo sapiens 38-42 1425908-3 1992 This growth-stimulatory activity for TS1 cells (GATS) was co-induced with IL-6 on normal fibroblasts and certain sarcoma cell lines stimulated with IL-1, double-stranded RNA, virus or phorbol ester. Phorbol Esters 184-197 interleukin 6 Homo sapiens 74-78 1425908-5 1992 GATS from phorbol ester-stimulated human hepatosarcoma cells co-purified with IL-6, but could be separated from it by subsequent cation-exchange fast-protein liquid chromatography and reverse-phase high-performance liquid chromatography. Phorbol Esters 10-23 interleukin 6 Homo sapiens 78-82 1328391-8 1992 In addition, the IgE/anti-IgE-induced IL-6 production was potentiated in the presence of cAMP inducer such as the beta 2-adrenoceptor agonist salbutamol. Albuterol 142-152 interleukin 6 Homo sapiens 38-42 1358047-3 1992 This response of the plasma glutamine levels was significantly correlated with the production of interleukin 6 but not with that of interleukin 1, tumor necrosis factor, or interferon gamma. Glutamine 28-37 interleukin 6 Homo sapiens 97-110 1591007-4 1992 In this study, we examine the role of amiloride for the regulation of AM-derived interleukin (IL)-8, tumor necrosis factor (TNF), IL-6, and IL-1 beta. Amiloride 38-47 interleukin 6 Homo sapiens 130-134 1591007-7 1992 Furthermore, the suppressive effect of amiloride appeared to be at the level of mRNA for IL-8, TNF, IL-1 beta, and IL-6, whereas steady-state levels of beta-actin mRNA remained unaltered. Amiloride 39-48 interleukin 6 Homo sapiens 115-119 1545152-3 1992 After 6-h treatment with the phorbol ester PMA, gene expression for IL-1 alpha, granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-3, and the IL-6 receptor were increased. Phorbol Esters 29-42 interleukin 6 Homo sapiens 153-157 1371302-4 1992 Megakaryocytic colony (CFU-Meg) formation from A-T-MNC or CD34+ cells in the presence of IL-6 + IL-3 + erythropoietin (Epo) was also markedly decreased after antisense oligodeoxynucleotide treatment. Oligodeoxyribonucleotides 168-188 interleukin 6 Homo sapiens 89-100 1730219-9 1992 The presence of the oligomannose structures and the mannose-terminating tetrasaccharide on IL-6 may be important in maintaining a high local concentration of the cytokine while limiting its systemic serum level via interaction with soluble mannose-binding serum lectins. Mannose 25-32 interleukin 6 Homo sapiens 91-95 1596939-10 1992 The growth effects of IL-6 on RCC were also investigated in two experimental systems: IL-6 was found to stimulate proliferative responses in six of six RCC tumor lines as measured by thymidine-uptake assays; however, only one of six tumor lines displayed an increase in proliferative response of greater than 21% (113%). Thymidine 183-192 interleukin 6 Homo sapiens 86-90 1800041-0 1991 Effect of panaxatriol ginsenoside on interleukin-6 mRNA translation. panaxatriol ginsenoside 10-33 interleukin 6 Homo sapiens 37-50 1912582-5 1991 The proliferative response of each line to recombinant IL-6 was measured in a clonogenic assay providing human plasma and methylcellulose as a viscous support and by 3H-thymidine uptake in liquid suspension culture. Thymidine 169-178 interleukin 6 Homo sapiens 55-59 1647881-2 1991 The presence of IL6 activity in SK-v cell-conditioned media (SK-v CM) was demonstrated by tritiated thymidine incorporation into IL6-dependent B9 murine plasmacytoma cells. Thymidine 100-109 interleukin 6 Homo sapiens 129-132 1864979-6 1991 There was a dose-dependent decrease, however, in [3H]-thymidine uptake in the presence of IL-6 antisense (and not sense) oligodeoxynucleotides; in the presence of 20 microM IL-6 antisense, an 80 and 95% inhibition of the proliferation of U 266 and RPMI 8226 cells was observed, respectively. Thymidine 54-63 interleukin 6 Homo sapiens 90-94 1864979-6 1991 There was a dose-dependent decrease, however, in [3H]-thymidine uptake in the presence of IL-6 antisense (and not sense) oligodeoxynucleotides; in the presence of 20 microM IL-6 antisense, an 80 and 95% inhibition of the proliferation of U 266 and RPMI 8226 cells was observed, respectively. Thymidine 54-63 interleukin 6 Homo sapiens 173-177 1864979-6 1991 There was a dose-dependent decrease, however, in [3H]-thymidine uptake in the presence of IL-6 antisense (and not sense) oligodeoxynucleotides; in the presence of 20 microM IL-6 antisense, an 80 and 95% inhibition of the proliferation of U 266 and RPMI 8226 cells was observed, respectively. Oligodeoxyribonucleotides 121-142 interleukin 6 Homo sapiens 90-94 2029798-3 1991 Interleukin-6 (IL-6) enhanced both Ig production and thymidine uptake by AF-10 and IM-9, while other cytokines, including IL-1 beta, IL-2, IL-3, IL-4, IL-5, granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon-alpha (IFN-alpha) or IFN-gamma, failed to do so. Thymidine 53-62 interleukin 6 Homo sapiens 0-13 2029798-3 1991 Interleukin-6 (IL-6) enhanced both Ig production and thymidine uptake by AF-10 and IM-9, while other cytokines, including IL-1 beta, IL-2, IL-3, IL-4, IL-5, granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon-alpha (IFN-alpha) or IFN-gamma, failed to do so. Thymidine 53-62 interleukin 6 Homo sapiens 15-19 1655518-12 1991 Staurosporine blocks cell-scattering caused by TPA but not that caused by IL-6 suggesting that IL-6 and TPA elicit similar phenotypic changes in breast cancer cells via different pathways. Staurosporine 0-13 interleukin 6 Homo sapiens 95-99 1715769-3 1990 Oligosaccharide analysis of recombinant IL 6 utilizing tunicamycin and endoglycosidases revealed O- and N-linked glycosylation that is comparable to that of natural IL 6 derived from human monocytes and fibroblasts. Tunicamycin 55-66 interleukin 6 Homo sapiens 40-44 2209699-3 1990 Tritiated thymidine suicide studies of BM incubated for 2 h with growth factors showed that almost one-half of megakaryocytic progenitors (CFU-Mk) preincubated with IL3 or IL3 plus IL6 were in S phase, whereas BM incubated with IL6 alone was similar to control (approximately 24% of CFU-Mk in S phase). Tritiated thymidine 0-19 interleukin 6 Homo sapiens 181-184 2209699-3 1990 Tritiated thymidine suicide studies of BM incubated for 2 h with growth factors showed that almost one-half of megakaryocytic progenitors (CFU-Mk) preincubated with IL3 or IL3 plus IL6 were in S phase, whereas BM incubated with IL6 alone was similar to control (approximately 24% of CFU-Mk in S phase). Tritiated thymidine 0-19 interleukin 6 Homo sapiens 228-231 2252806-6 1990 IL-6 production was significantly reduced in the presence of Cuprophan (151 +/- 45 pg/ml), Hemophan (167 +/- 6 pg/ml), and polyacrylonitrile (108 +/- 33 pg/ml) when compared with polystyrole (724 +/- 34 pg/ml). cuprammonium cellulose 61-70 interleukin 6 Homo sapiens 0-4 2346778-3 1990 After incubation of 2 to 5 x 10(6) cells/mL for 4 hours in 5.0 ng IL-6/mL, increased thymidine suicide rates were observed for multipotent progenitors (CFU-Mix), granulocyte-macrophage progenitors (CFU-GM), and erythroid burst-forming units (BFU-E). Thymidine 85-94 interleukin 6 Homo sapiens 66-70 2346778-4 1990 Similar incubations of fetal cells in IL-6 resulted in similar increases in tritiated thymidine suicide rates. Tritiated thymidine 76-95 interleukin 6 Homo sapiens 38-42 2341719-0 1990 Transcriptional modulation of human IL-6 gene expression by verapamil. Verapamil 60-69 interleukin 6 Homo sapiens 36-40 2341719-3 1990 In sharp contrast, the addition of verapamil to PHA and PMA-stimulated PBMC augmented the mitogen-stimulated increases in nuclear transcription of IL-6-encoding mRNA, steady state levels of IL-6 encoding mRNA, and release of IL-6 bioactivity. Verapamil 35-44 interleukin 6 Homo sapiens 147-151 2341719-3 1990 In sharp contrast, the addition of verapamil to PHA and PMA-stimulated PBMC augmented the mitogen-stimulated increases in nuclear transcription of IL-6-encoding mRNA, steady state levels of IL-6 encoding mRNA, and release of IL-6 bioactivity. Verapamil 35-44 interleukin 6 Homo sapiens 190-194 2341719-3 1990 In sharp contrast, the addition of verapamil to PHA and PMA-stimulated PBMC augmented the mitogen-stimulated increases in nuclear transcription of IL-6-encoding mRNA, steady state levels of IL-6 encoding mRNA, and release of IL-6 bioactivity. Verapamil 35-44 interleukin 6 Homo sapiens 190-194 2341719-6 1990 We suggest that a non-calcium-dependent, IL-6 regulatory factor, absent or inactive in verapamil-treated cultures, inhibits IL-6 gene activation in mitogen-stimulated PBMC. Verapamil 87-96 interleukin 6 Homo sapiens 41-45 2341719-6 1990 We suggest that a non-calcium-dependent, IL-6 regulatory factor, absent or inactive in verapamil-treated cultures, inhibits IL-6 gene activation in mitogen-stimulated PBMC. Verapamil 87-96 interleukin 6 Homo sapiens 124-128 1693429-5 1990 The IL-6-R was functional, as [3H]thymidine incorporation by AIDS-KS cells increased significantly after exposure to human recombinant IL-6 (hrIL-6) at greater than 10 units/ml. Thymidine 34-43 interleukin 6 Homo sapiens 4-8 33379200-8 2020 Both iron oxide and silica enhanced LPS-induced production of TNF-alpha, IL-1beta, IL-6 and IL-8 in THP-1 cells with most of these responses replicated in PBMCs. Silicon Dioxide 20-26 interleukin 6 Homo sapiens 83-87 32207044-0 2020 Dp44mT, an iron chelator, suppresses growth and induces apoptosis via RORA-mediated NDRG2-IL6/JAK2/STAT3 signaling in glioma. di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone 0-6 interleukin 6 Homo sapiens 90-93 29101672-8 2018 We found significant difference between IL-6 concentrations and disease activity (p 0.028), hypertriglyceridemia (p 0.023), LDL-C (p 0.029), and smoking (0.005). ldl-c 124-129 interleukin 6 Homo sapiens 40-44 17466660-10 2007 Release of muscle-derived interleukin-6 may play a role in the nonosmotic secretion of arginine vasopressin, thereby linking rhabdomyolysis to the pathogenesis of EAH. eah 163-166 interleukin 6 Homo sapiens 26-39 9201266-1 1997 Our previous studies demonstrated that both in vivo and in vitro 3,4-dichloro-propionanilide (propanil) exposure inhibited interleukin-6 (IL-6) and tumor necrosis factor (TNF) production by adherent thioglycollate-elicited peritoneal cells (macrophages) after lipopolysaccharide (LPS) stimulation. 3,4-dichloropropionanilide 65-92 interleukin 6 Homo sapiens 123-136 9201266-1 1997 Our previous studies demonstrated that both in vivo and in vitro 3,4-dichloro-propionanilide (propanil) exposure inhibited interleukin-6 (IL-6) and tumor necrosis factor (TNF) production by adherent thioglycollate-elicited peritoneal cells (macrophages) after lipopolysaccharide (LPS) stimulation. 3,4-dichloropropionanilide 65-92 interleukin 6 Homo sapiens 138-142 9201266-1 1997 Our previous studies demonstrated that both in vivo and in vitro 3,4-dichloro-propionanilide (propanil) exposure inhibited interleukin-6 (IL-6) and tumor necrosis factor (TNF) production by adherent thioglycollate-elicited peritoneal cells (macrophages) after lipopolysaccharide (LPS) stimulation. 3,4-dichloropropionanilide 94-102 interleukin 6 Homo sapiens 123-136 9201266-1 1997 Our previous studies demonstrated that both in vivo and in vitro 3,4-dichloro-propionanilide (propanil) exposure inhibited interleukin-6 (IL-6) and tumor necrosis factor (TNF) production by adherent thioglycollate-elicited peritoneal cells (macrophages) after lipopolysaccharide (LPS) stimulation. 3,4-dichloropropionanilide 94-102 interleukin 6 Homo sapiens 138-142 9201266-2 1997 In this study, we report that IL-6 and TNF-alpha message is reduced by propanil in a concentration-dependent pattern, yet the stability of cytokine mRNA is not affected. 3,4-dichloropropionanilide 71-79 interleukin 6 Homo sapiens 30-34 9201266-3 1997 In addition, exposure of macrophages to propanil after a relatively short period of LPS stimulation significantly reduced the production of IL-6 and TNF. 3,4-dichloropropionanilide 40-48 interleukin 6 Homo sapiens 140-144 34342722-8 2022 The application of dexmedetomidine in cardiac surgery with CPB can reduce CK-MB and cTn-I concentration and interleukin-6, tumor necrosis factor-alpha levels to a certain extent and shorten the length of Intensive Care Unit stay, but it has no significant effect on IL-10 level, C reactive protein level, the time on ventilator and length of hospital stay. Dexmedetomidine 19-34 interleukin 6 Homo sapiens 108-121 34902346-9 2022 Kynurenine and the KYN/TRP ratio significantly correlated with IL-6 (rho = 0.441 and 0.448, p-values < 0.001). Kynurenine 0-10 interleukin 6 Homo sapiens 63-67 34902346-9 2022 Kynurenine and the KYN/TRP ratio significantly correlated with IL-6 (rho = 0.441 and 0.448, p-values < 0.001). Kynurenine 19-22 interleukin 6 Homo sapiens 63-67 34801521-6 2022 We screened an epigenetic modifier library for compounds that reduced intracellular IL-6 production induced by the PKC agonist Ingenol-3,20-dibenzoate. ingenol dibenzoate 127-150 interleukin 6 Homo sapiens 84-88 34815622-4 2022 Epigallocatechin-3-gallate - a polyphenol from tea - effectively has been shown to inhibit the activity of SARS-CoV-2 as it blocked binding of coronavirus 2 to human angiotensin converting enzyme 2, decreased the expression of inflammatory factors in the blood, including tumor necrosis factor-alpha and interleukin-6, and significantly increased the overall fertilization efficiency in animals. epigallocatechin gallate 0-26 interleukin 6 Homo sapiens 304-317 34801680-7 2022 Treatment of wounded skin with MEL-DCL nano-complexes showed significant reduction of IL-6, IL-1beta, and TNF-alpha pro-inflammatory markers that was paralleled by a substantial increase in mRNA expression levels of collagen, type I, alpha 1 (Col1A1) and collagen, type IV, alpha 1 (Col4A1), and hydroxyproline content as compared to individual drugs. mel-dcl 31-38 interleukin 6 Homo sapiens 86-90 34955648-15 2021 Conclusion: Co and Ni induce secretion of IL-6 in human BSMCs through activation of OGR1. Cobalt 12-14 interleukin 6 Homo sapiens 42-46 34725715-7 2021 RESULTS: Isoprenaline and formoterol (both beta2 agonists) induced IL-6, but not IL-8, release, which could be inhibited by ICI 118,551 (beta2 antagonist). Isoproterenol 9-21 interleukin 6 Homo sapiens 67-71 34725715-10 2021 Isoprenaline-mediated IL-6 secretion was attenuated by dasatinib, a Src inhibitor, and PD98059, an ERK1/2 inhibitor. Isoproterenol 0-12 interleukin 6 Homo sapiens 22-26 34725715-10 2021 Isoprenaline-mediated IL-6 secretion was attenuated by dasatinib, a Src inhibitor, and PD98059, an ERK1/2 inhibitor. Dasatinib 55-64 interleukin 6 Homo sapiens 22-26 34940303-11 2021 Meanwhile, the levels of nuclear factor kappa beta, interleukins 6 and 1 beta, and tumour necrosis alpha (NF-kB, IL-6, IL-1beta, and TNF-alpha, respectively) were lower for ABX-NS compared to free ABX (p < 0.05). Ambroxol 173-176 interleukin 6 Homo sapiens 52-77 34940303-11 2021 Meanwhile, the levels of nuclear factor kappa beta, interleukins 6 and 1 beta, and tumour necrosis alpha (NF-kB, IL-6, IL-1beta, and TNF-alpha, respectively) were lower for ABX-NS compared to free ABX (p < 0.05). Ambroxol 173-176 interleukin 6 Homo sapiens 113-117 34940303-11 2021 Meanwhile, the levels of nuclear factor kappa beta, interleukins 6 and 1 beta, and tumour necrosis alpha (NF-kB, IL-6, IL-1beta, and TNF-alpha, respectively) were lower for ABX-NS compared to free ABX (p < 0.05). Ambroxol 197-200 interleukin 6 Homo sapiens 52-77 34884773-7 2021 According to our flow cytometry and confocal microscopy data, chelidonine abrogated IL-6-induced activation and nuclear translocation, but amplified constitutive serine phosphorylation of STAT3. chelidonine 62-73 interleukin 6 Homo sapiens 84-88 34831450-10 2021 Furthermore, histone acetylation inhibition by anacardic acid or curcumin reduces IL-6 production. anacardic acid 47-61 interleukin 6 Homo sapiens 82-86 34831450-11 2021 Notably, inhibition of histone deacetylase (HDAC) activity by trichostatin A (TSA) resulted in the further elevation of IL-6 expression in response to combined treatment of adipocytes with IL-1beta and TNFalpha. trichostatin A 62-76 interleukin 6 Homo sapiens 120-124 34831450-11 2021 Notably, inhibition of histone deacetylase (HDAC) activity by trichostatin A (TSA) resulted in the further elevation of IL-6 expression in response to combined treatment of adipocytes with IL-1beta and TNFalpha. trichostatin A 78-81 interleukin 6 Homo sapiens 120-124 34764420-9 2021 Serum levels of IL-6 and TNFalpha were reduced in both tramadol-treated group 1 and 2 compared to the control group. Tramadol 55-63 interleukin 6 Homo sapiens 16-20 34785925-8 2021 Furthermore, blocking Stat3 signaling pathway by treatment with TSA and/or small molecule compound Stattic of an p-Stat3 inhibitor effectively abrogated LPS-induced tumorosphere forming with decrease of IL-6, IL-8 and stemness biomarkers CD44, SOX-2 expression. trichostatin A 64-67 interleukin 6 Homo sapiens 203-207 34785925-10 2021 TSA could prevent, at least in part, the LPS-induced malignant transformation by targeting p-Stat3/c-Myc signaling pathway and reducing inflammatory IL-6, IL-8. trichostatin A 0-3 interleukin 6 Homo sapiens 149-153 34803718-12 2021 JZ-1 administration obviously ameliorates inflammatory responses with reduced T-lymphocytes, T helper cells, macrophages and neutrophils infiltration, and local IL-1beta, IL-6, TNF-alpha and CCL2 levels. jz-1 0-4 interleukin 6 Homo sapiens 171-175 34630655-7 2021 The present study revealed that among the isoflavone derivatives examined (daidzein, genistein and glycitein), daidzein inhibited the production of IL-6, but not IL-8, by IL-1beta-stimulated synovial MH7A cells via the suppression of NF-kappaB p65 and ERK1/2 activation. Genistein 85-94 interleukin 6 Homo sapiens 148-152 34186308-6 2021 Liver IL-6, IL-1beta and hepcidin expression were significantly increased following LCHS/CS-14. Cesium 89-91 interleukin 6 Homo sapiens 6-10 34688540-9 2022 The expressions of TNF-alpha, IL-6, and PiT-1 in human monocytes were significantly increased in a dose-dependent manner after treatment with HP, which was subsequently inhibited by NPT antagonist phosphonoformic acid. Foscarnet 197-217 interleukin 6 Homo sapiens 30-34 34590104-0 2021 Photoelectrochemical immunoassay of interleukin-6 based on covalent reaction-triggered photocurrent polarity switching of ZnO@fullerenol. Zinc Oxide 122-125 interleukin 6 Homo sapiens 36-49 34590104-2 2021 The sensitive detection of interleukin-6 is achieved by using CA-encapsulated liposome as the label and COH-coated ZnO as the photoactive material, with a detection limit of 1.0 fg mL-1. Zinc Oxide 115-118 interleukin 6 Homo sapiens 27-40 34617520-6 2021 RESULTS AND CONCLUSION: The combination of PFLC with AFMC caused a reduction of ROS generation, reduced IL-6 production and suppressed the expression of COX-2. pflc 43-47 interleukin 6 Homo sapiens 104-108 34671275-13 2021 CXCL8, IL6, and IL1B were increased by the MRTF-SRF inhibitor CCG-1423 and by MRTF-A silencing in hCASMCs, but depolymerization of actin, known to inhibit MRTF activity, had no stimulatory effect, an exception being IL1B. CCG 1423 62-70 interleukin 6 Homo sapiens 7-10 34616125-6 2021 Cytokine array and enzymelinked immunosorbent assay analysis showed increased expression of inflammatory cytokines such as interleukin6 and granulocyte-macrophage colony-stimulating factor by polyinosinic-polycytidylic acid stimulation, with expression levels differing according to hot springs hydrochemical composition. Poly C 205-223 interleukin 6 Homo sapiens 123-135 34616170-11 2021 The in vitro experiments indicated that overexpression of miR-23a-3p reversed the promotive effect of LPS on HaCaT cell proliferation and reduced the protein levels of TNF-alpha and IL-6. mir-23a-3p 58-68 interleukin 6 Homo sapiens 182-186 34630379-5 2021 Recently, it was reported that auranofin reduced by 95% SARS-CoV-2 RNA in infected human cells in vitro and decreased SARS-CoV-2-induced cytokine expression, including IL-6. Auranofin 31-40 interleukin 6 Homo sapiens 168-172 34630379-7 2021 Therefore, auranofin could, in our point of view, reduce pathology due to SARS-CoV-2-induced IL-6. Auranofin 11-20 interleukin 6 Homo sapiens 93-97 34572149-6 2021 In this study, palmitate markedly synergizes the IL-26-induced proinflammatory effects and matrix protease, including COX-2, IL-6, and MMP-1, in HACs via the toll-like receptor 4 (TLR4)-ERK1/2-c-Jun signal transduction pathway. Palmitates 15-24 interleukin 6 Homo sapiens 125-129 34479552-11 2021 CONCLUSIONS: Luteoklin, quercetin, kaempferol and other active compounds in Epicedium can regulate multiple signaling pathways and targets such as IL6, AKT1, and EGF, therefore playing therapeutic roles in depression. luteoklin 13-22 interleukin 6 Homo sapiens 147-150 34479552-11 2021 CONCLUSIONS: Luteoklin, quercetin, kaempferol and other active compounds in Epicedium can regulate multiple signaling pathways and targets such as IL6, AKT1, and EGF, therefore playing therapeutic roles in depression. epicedium 76-85 interleukin 6 Homo sapiens 147-150 34504537-8 2021 EFE inhibited the expression of MMP-1, MMP-3, and proinflammatory cytokines (TNF-alpha, IL-6, and IL-8) in IL-1beta-stimulated HGFs through the inhibition of IL-1beta-induced MAPK/STAT-3 activation. EFE 0-3 interleukin 6 Homo sapiens 88-92 34512638-9 2021 In addition, 1,25D3 decreased the expression of IL-6, IFN-beta1, CCL2, FN1 and COL1A1 induced by polyI:C in BSMCs. Poly C 97-104 interleukin 6 Homo sapiens 48-52 34443939-0 2021 Laser Scribing Fabrication of Graphitic Carbon Biosensors for Label-Free Detection of Interleukin-6. graphitic 30-39 interleukin 6 Homo sapiens 86-99 34444963-1 2021 We report the effects of mixed omega-7 fatty acid supplementation on changes in serum hsCRP, TNFalpha, and IL-6 levels and self-reported outcomes in people with non-specific chronic musculoskeletal discomfort. omega-7 fatty acid 31-49 interleukin 6 Homo sapiens 107-111 34445126-9 2021 Metaxalone decreased MAO-A activity and expression, reduced NF-kB, TNF-alpha, and IL-6, enhanced IL-13, and also increased PPARgamma, PGC-1alpha, and Nrf2 expression. metaxalone 0-10 interleukin 6 Homo sapiens 82-86 34277422-7 2021 EPZ-6438 treatment also resulted in a rapid and sustained induction of the genes encoding HIF2alpha (Hypoxia Inducible Factor 2alpha), TG2 (Transglutaminase 2) and IL-6 (Interleukin 6). tazemetostat 0-8 interleukin 6 Homo sapiens 164-168 34277422-7 2021 EPZ-6438 treatment also resulted in a rapid and sustained induction of the genes encoding HIF2alpha (Hypoxia Inducible Factor 2alpha), TG2 (Transglutaminase 2) and IL-6 (Interleukin 6). tazemetostat 0-8 interleukin 6 Homo sapiens 170-183 34163151-8 2021 Results: Three phytocompounds including isoorientin, lupeol, and andrographolide have shown strong interactions with the targeted protein IL-6 with least binding energies (-7.1 to -7.7 kcal/mol). lupeol 53-59 interleukin 6 Homo sapiens 138-142 34086734-0 2021 Dose- and time-dependent changes in viability and IL-6, CXCL8 and CCL2 production by HaCaT-cells exposed to cobalt. Cobalt 108-114 interleukin 6 Homo sapiens 50-54 34086734-12 2021 A linear mixed statistical model showed that cobalt exposure induces increase in IL-6, CXCL8 and CCL2 production over time and whereas increase of IL-6 and a decrease of CCL2 was associated with increasing cobalt chloride concentrations. Cobalt 45-51 interleukin 6 Homo sapiens 81-85 34086734-12 2021 A linear mixed statistical model showed that cobalt exposure induces increase in IL-6, CXCL8 and CCL2 production over time and whereas increase of IL-6 and a decrease of CCL2 was associated with increasing cobalt chloride concentrations. Cobalt 45-51 interleukin 6 Homo sapiens 147-151 2511437-5 1989 The 115-base pair (bp) region from -225 to -111 in the IL-6 5"-flanking region, which shares nucleotide sequence similarity with the c-fos serum response (SRE) and adjacent AP-1-like (the CGTCA motif) elements, confers responsiveness to several reagents, including serum, forskolin, and phorbol ester, upon the heterologous herpesvirus thymidine kinase (TK) promoter. Colforsin 272-281 interleukin 6 Homo sapiens 55-59 34114392-6 2021 RESULTS: The results showed that BYF, BJF and YZF treatment strongly decreased the CSE-induced secretion of interleukin (IL)-6, IL-8, tumor necrosis factor-alpha and matrix metalloproteinase-9 by THP-1 cells. bjf 38-41 interleukin 6 Homo sapiens 108-126 2511437-9 1989 Mutations in the AP-1-like site within AR1 (CGTCA----GTTCA) decreased inducibility of the chimeric IL-6/TK/chloramphenicol acetyltransferase gene by phorbol ester and by forskolin but not by serum, IL-1 alpha, or tumor necrosis factor. Colforsin 170-179 interleukin 6 Homo sapiens 99-103 34063891-8 2021 The dysregulation of chemoresistance-associated genes and the inhibition of cytokines such as IL-6 by the model polymer construct, PEG-BA, holds promise for further exploration in PC treatment. Polymers 112-119 interleukin 6 Homo sapiens 94-98 2544300-4 1989 The presence of IL-6 stimulated 51Cr release from labeled, opsonized targets by 67.1% (from 21.6 +/- 1.4% to 36.1 +/- 1.3% at 10 U of IL-6 (P less than 0.01)). Chromium-51 32-36 interleukin 6 Homo sapiens 16-20 34348637-6 2021 Additionally, triterpene acid mixture (ursolic acid, oleanolic acid, and betulinic acid), also isolated from rosehip, has been reported to reduce the production of interleukin-6 and Tumor necrosis factor-alpha. ursolic acid 39-51 interleukin 6 Homo sapiens 164-177 2544300-4 1989 The presence of IL-6 stimulated 51Cr release from labeled, opsonized targets by 67.1% (from 21.6 +/- 1.4% to 36.1 +/- 1.3% at 10 U of IL-6 (P less than 0.01)). Chromium-51 32-36 interleukin 6 Homo sapiens 134-138 35612514-11 2022 Western blot assay demonstrated that 11c inhibited IL-6-mediated activation of PI3K/Akt pathway. Carbon-11 37-40 interleukin 6 Homo sapiens 51-55 35612514-12 2022 A docking study revealed that 11c had stronger binding interaction with the residues of IL-6 than SIN. Carbon-11 30-33 interleukin 6 Homo sapiens 88-92 2731990-4 1989 By measuring IL-1 TNF-alpha, and IL-6, the interaction of different LPSs or lipid A with human serum could be shown to prevent the activation of human monocytes. Lipid A 76-83 interleukin 6 Homo sapiens 33-37 35612514-13 2022 All these results indicate that 11c may be a potential anti-breast cancer agent by directly targeting IL-6. Carbon-11 32-35 interleukin 6 Homo sapiens 102-106 35562182-7 2022 Multiple cycles of intravenous c-JO4 plus Doxil (four cycles, 4 weeks apart, simulating the treatment regimen in the clinical trial) elicited antibodies against c-JO4 that increased with each cycle and were accompanied by elevation of pro-inflammatory cytokines IL-6 and TNFalpha. liposomal doxorubicin 42-47 interleukin 6 Homo sapiens 262-266 2476083-8 1989 Both dexamethasone and 13-cis-RA also reduced the mRNA level of glyceraldehyde-3-phosphate dehydrogenase, indicating that glucocorticoids and retinoids have both similar and different effects on gene expression in HSF. Retinoids 142-151 interleukin 6 Homo sapiens 214-217 35150455-17 2022 Analysis of cytokines suggested a dominant pro-inflammatory T-cell response and osteodestructive function of IL-6 in PLs judging by Th17/Tfh cell activation, Tregs inhibition and increased RANKL/OPG ratio. tregs 158-163 interleukin 6 Homo sapiens 109-113 2472978-0 1989 Different preparations of natural and recombinant human interleukin-6 (IFN-beta 2, BSF-2) similarly stimulate acute phase protein synthesis and uptake of alpha-aminoisobutyric acid by cultured rat hepatocytes. 2-aminoisobutyric acid 154-180 interleukin 6 Homo sapiens 56-69 2472978-0 1989 Different preparations of natural and recombinant human interleukin-6 (IFN-beta 2, BSF-2) similarly stimulate acute phase protein synthesis and uptake of alpha-aminoisobutyric acid by cultured rat hepatocytes. 2-aminoisobutyric acid 154-180 interleukin 6 Homo sapiens 71-81 2472978-0 1989 Different preparations of natural and recombinant human interleukin-6 (IFN-beta 2, BSF-2) similarly stimulate acute phase protein synthesis and uptake of alpha-aminoisobutyric acid by cultured rat hepatocytes. 2-aminoisobutyric acid 154-180 interleukin 6 Homo sapiens 83-88 35509853-9 2022 Additionally, miR-141-3p could reduce IL-6 and IL-8. mir-141-3p 14-24 interleukin 6 Homo sapiens 38-42 6440265-2 1984 This is coupled with 51% and 61% decreases of the NADPH/NADP+ ratio in the G6PD-deficient human lymphocytes (HL) and human skin fibroblasts (HSF), respectively. NADP 50-55 interleukin 6 Homo sapiens 141-144 6440265-2 1984 This is coupled with 51% and 61% decreases of the NADPH/NADP+ ratio in the G6PD-deficient human lymphocytes (HL) and human skin fibroblasts (HSF), respectively. NADP 56-61 interleukin 6 Homo sapiens 141-144 6440265-9 1984 The NADPH-cytochrome c (P450) reductase of G6PD-deficient HL and HSF homogenates becomes lower than that of controls when endogenous G6PD and exogenous glucose 6-phosphate (G6P) and NADP+ are used as a hydrogen donor system in place of NADPH. NADP 182-187 interleukin 6 Homo sapiens 65-68 6440265-9 1984 The NADPH-cytochrome c (P450) reductase of G6PD-deficient HL and HSF homogenates becomes lower than that of controls when endogenous G6PD and exogenous glucose 6-phosphate (G6P) and NADP+ are used as a hydrogen donor system in place of NADPH. NADP 4-9 interleukin 6 Homo sapiens 65-68 33894403-7 2021 Furthermore, NP-RLX ameliorated the chronic AAD-induced AI, pro-inflammatory cytokines (IL-1beta, IL-6, TNF-alpha), chemokines (CCL2, CCL11) and the pro-fibrotic TGF-beta1/IL-1beta axis on AWR and resulting AHR, as well as human myofibroblast-induced collagen gel contraction, to a similar extent as unconjugated RLX. Relaxin 16-19 interleukin 6 Homo sapiens 98-102 35417716-5 2022 Importantly, P. falciparum-infected red blood cells incubated with MTI or cultivated with MTA and immucillin lead to TLR8-dependent interleukin-6 (IL-6) production in human monocytes. immucillin 98-108 interleukin 6 Homo sapiens 132-145 2789322-3 1989 We compared the capacity of EC and SMC to produce interleukin 6 (IL6) in response to LPS or its lipid A moiety. Lipid A 96-103 interleukin 6 Homo sapiens 50-63 2789322-3 1989 We compared the capacity of EC and SMC to produce interleukin 6 (IL6) in response to LPS or its lipid A moiety. Lipid A 96-103 interleukin 6 Homo sapiens 65-68 2789322-6 1989 Lipid A also augmented IL6 production by both EC and SMC. Lipid A 0-7 interleukin 6 Homo sapiens 23-26 2523818-4 1989 The latter had an electrophoretic mobility indistinguishable from that of 125I-labeled recombinant human IL-6. Iodine-125 74-78 interleukin 6 Homo sapiens 105-109 33141877-8 2021 CONCLUSION: IL-6 levels were elevated and independently associated with low dynamic lung function and airflow limitation in well-treated PWH, suggesting that systemic inflammation may contribute to the pathogenesis of chronic pulmonary diseases. PWH 137-140 interleukin 6 Homo sapiens 12-16 35417716-5 2022 Importantly, P. falciparum-infected red blood cells incubated with MTI or cultivated with MTA and immucillin lead to TLR8-dependent interleukin-6 (IL-6) production in human monocytes. immucillin 98-108 interleukin 6 Homo sapiens 147-151 35409099-5 2022 Interestingly, 3-TYP caused an increase in gene expression of adipocyte-specific cytokines including IL6, resistin, and TNF-alpha. 3-TYP 15-20 interleukin 6 Homo sapiens 101-104 33958662-5 2021 Exogenous 11,12-EET and 19,20-EDP significantly decreased PA- and IL-1beta-induced MC expression of IL-1beta and IL-6. 11,12-epoxy-5,8,14-eicosatrienoic acid 10-19 interleukin 6 Homo sapiens 113-117 2536035-7 1989 Forskolin was also found to have a marked stimulatory effect on the expression of interferon-beta 2 mRNA expression. Colforsin 0-9 interleukin 6 Homo sapiens 82-99 3218613-6 1988 Increasing substrate concentration (9-144 nmols) relieved the inhibition of HSF-PLA2 activity by quercetin indicating probable interaction with the substrate. Quercetin 97-106 interleukin 6 Homo sapiens 76-79 35378948-0 2022 Clinical Effect of Bushen Huoxue Method Combined with Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis and Its Effect on IL-1, IL-6, VEGF, and PGE-2. huoxue 26-32 interleukin 6 Homo sapiens 139-143 3006091-2 1986 The specific binding and internalization of human 125I-labeled LDL are dose-dependently increased in HSF by CA of the verapamil series (verapamil, anipamil, gallopamil, ronipamil, and diltiazem), but neither by CA of the dihydropyridine series (nifedipine, nitrendipine) nor by flunarizine. Iodine-125 50-54 interleukin 6 Homo sapiens 101-104 34033999-0 2021 Sulforaphane inhibits the expression of interleukin-6 and interleukin-8 induced in bronchial epithelial IB3-1 cells by exposure to the SARS-CoV-2 Spike protein. sulforaphane 0-12 interleukin 6 Homo sapiens 40-53 34035660-8 2021 Results: In IL-1beta-primed cells, preincubation with Vanillin reduced IL-6, IL-8, COX-2, and iNOS expression and NO release, compared to IL-1beta-primed cells. vanillin 54-62 interleukin 6 Homo sapiens 71-75 34035660-10 2021 Furthermore, in presence of mechanical injury, the Vanillin preincubation, wound closure may be reducing the expression and release of IL-6 and TNF-alpha and upregulation of COX-2 and IL-8. vanillin 51-59 interleukin 6 Homo sapiens 135-139 35582294-11 2022 Both EcN and rifaximin produced similar significant reductions in the proinflammatory cytokines INF-gamma, IL-6 and IL-8. Rifaximin 13-22 interleukin 6 Homo sapiens 107-111 33998900-7 2021 Results: Tumor necrosis factor alpha, interleukin (IL)-1beta, IL-6, and interferon gamma were the most commonly studied pro-inflammatory cytokines and their levels were consistently reduced after treatment with CBD, CBG, or CBD+THC, but not with THC alone. cannabigerol 216-219 interleukin 6 Homo sapiens 62-66 33982762-3 2021 The results of ELISA and reverse transcription-quantitative PCR revealed that THCA reduced the secretion and mRNA expression levels of interleukin (IL)-6; IL-8; thymus and activation-regulated chemokine; macrophage-derived chemokine; regulated upon activation, normal T cell expressed and secreted; and monocyte chemoattractant protein-1 in TI mixture-stimulated HaCaT cells. thca 78-82 interleukin 6 Homo sapiens 135-153 33756033-1 2021 A library of glycoforms of human interleukin 6 (IL-6) comprising complex and mannosidic N-glycans was generated by semisynthesis. n-glycans 88-97 interleukin 6 Homo sapiens 33-46 33756033-1 2021 A library of glycoforms of human interleukin 6 (IL-6) comprising complex and mannosidic N-glycans was generated by semisynthesis. n-glycans 88-97 interleukin 6 Homo sapiens 48-52 35401236-4 2022 In vivo, our results showed that AKEX0011 ameliorated silica-induced imaging lung damages, respiratory dysfunction, reduced the secretion of inflammatory and fibrotic factors (TNF-alpha, IL-1beta, IL-6, TGF-beta, IL-4, and IL-10), and the deposition of fibrosis-related proteins (collagen I, fibronectin, and alpha-SMA), regardless of early or advanced therapy. Silicon Dioxide 54-60 interleukin 6 Homo sapiens 197-201 34054304-6 2021 Results: LW402 exhibited potent nanomolar activity against JAK1 and showed a 45-fold selectivity for inhibition of JAK1- over JAK2-dependent signaling induced by either IL6 or GM-CSF in human whole-blood assays. lw402 9-14 interleukin 6 Homo sapiens 169-172 33967777-9 2021 Specifically, minocycline is effective in reducing COVID-19-related complications, through attenuation of cytokine storm as apparent by reduction of interleukin (IL)-6, IL-1, and tumor necrosis factor (TNF)-alpha. Minocycline 14-25 interleukin 6 Homo sapiens 149-167 33860869-10 2021 Further experiments revealed that S1-induced increase in the production of TNFalpha, IL-6, IL-1beta and IL-8 was reduced in the presence of BAY11-7082 and SKF 86002, while CRID3 pre-treatment resulted in the reduction of IL-1beta production. 3-(4-methylphenylsulfonyl)-2-propenenitrile 140-150 interleukin 6 Homo sapiens 85-89 35241186-7 2022 In addition, omega-3 PUFAs supplementation decreased the levels of pro-inflammatory mediators including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and hypersensitive-c-reactive protein (Hs-CRP). omega-3 pufas 13-26 interleukin 6 Homo sapiens 145-158 33855585-0 2022 Baseline Interleukin-6 and -8 predict response and survival in patients with advanced hepatocellular carcinoma treated with sorafenib monotherapy: an exploratory post hoc analysis of the SORAMIC trial. Sorafenib 124-133 interleukin 6 Homo sapiens 9-29 33855585-9 2022 CONCLUSION: IL-6 and IL-8 baseline values predicted outcomes of sorafenib-treated patients in this well-characterized prospective cohort of the SORAMIC trial. Sorafenib 64-73 interleukin 6 Homo sapiens 12-16 33998306-11 2021 Early treatment with CytoSorb decreased interleukin 6 plasma levels and inflammatory indexes, resulting in earlier stabilization of homeostasis. cytosorb 21-29 interleukin 6 Homo sapiens 40-53 35241186-7 2022 In addition, omega-3 PUFAs supplementation decreased the levels of pro-inflammatory mediators including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and hypersensitive-c-reactive protein (Hs-CRP). omega-3 pufas 13-26 interleukin 6 Homo sapiens 160-164 33993290-9 2021 The A2B agonist BAY60-6583 significantly elevated levels of IL6 and CXCL8, a result also obtained with adenosine and its analogue NECA. BAY 60-6583 16-26 interleukin 6 Homo sapiens 60-63 35144130-8 2022 Our results indicated that after B(a)P exposure, TNF-alpha and IL-6 in the supernatant were increased. Phosphorus 37-38 interleukin 6 Homo sapiens 63-67 33964033-13 2021 Fluvastatin reduced IL8, IL6, CCL21, AQP9 (p<0.001) and MMP9 (p<0.05) in the ex-vivo pulpitis model, while dequalinium chloride reduced AQP9 (p<0.001) but had no significant effect on the other biomarkers. Fluvastatin 0-11 interleukin 6 Homo sapiens 25-28 33839199-19 2021 Finally, we discovered that treat with aloin A markedly decreased IL-6 levels and increased MUC2 expression in LPS-stimulated LS174T cell. alloin 39-46 interleukin 6 Homo sapiens 66-70 35172141-4 2022 IL-6, via its trans-signaling pathway, induces changes in the neuronal iron transcriptome that promote ferrous iron uptake and decrease cellular iron export via a pathway we term the cellular iron sequestration response, or CISR. ferrous iron 103-115 interleukin 6 Homo sapiens 0-4 33961144-7 2021 Flavonoids have also exhibited an anti-inflammatory effect relevant to neuropathic pain, as evidenced by the reduction in multiple pro-inflammatory mediators, such as TNF-alpha, NF-kappaB, IL-1beta, and IL-6. Flavonoids 0-10 interleukin 6 Homo sapiens 203-207 35162939-8 2022 PM10-treated NPDFs significantly upregulated interleukin (IL)-6, IL-4, and IL-33 expression and CXCL1 protein levels than PM10-treated normal tissues. pm10 0-4 interleukin 6 Homo sapiens 45-63 34035828-9 2021 Further analysis showed that the HGD activity of quercetin, formononetin, kaempferol, isorhamnetin, and beta-sitosterol ingredients is possible through VEGFA, IL6, TNF, AKT1, and TP53 targets involved in TNF, toll-like receptors, and MAPK-related pathways, which have anti-inflammatory, antiapoptosis, antioxidation, and autophagy effects, relieve renal fibrosis and renal cortex injury, and improve renal function, thus delaying the development of DN. Quercetin 49-58 interleukin 6 Homo sapiens 159-162 34035828-9 2021 Further analysis showed that the HGD activity of quercetin, formononetin, kaempferol, isorhamnetin, and beta-sitosterol ingredients is possible through VEGFA, IL6, TNF, AKT1, and TP53 targets involved in TNF, toll-like receptors, and MAPK-related pathways, which have anti-inflammatory, antiapoptosis, antioxidation, and autophagy effects, relieve renal fibrosis and renal cortex injury, and improve renal function, thus delaying the development of DN. formononetin 60-72 interleukin 6 Homo sapiens 159-162 33504955-8 2021 Responders to minocycline had higher baseline IL-6 concentrations than non-responders (p = 0.03); IFNgamma was significantly reduced after treatment with minocycline compared with placebo (p = 0.03). Minocycline 14-25 interleukin 6 Homo sapiens 46-50 35016642-9 2022 The proliferation ability and the release of IL-6, TNF-alpha, and TGF-beta in human mesangial cells (HMCs) were measured after stimulating with SA-IgG-IgA1-IC and NSA-IgG-IgA1-IC. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 144-146 interleukin 6 Homo sapiens 45-49 32746708-7 2021 GO and MGO increased production of pro-inflammatory such as interleukin (IL)-1beta and IL-6) and MUC5AC/5B. Glyoxal 0-2 interleukin 6 Homo sapiens 87-91 32746708-10 2021 These significantly repressed GO- and MGO-induced expression of pro-inflammatory cytokines (IL-1beta and IL-6) and MUC5AC/5B. Glyoxal 30-32 interleukin 6 Homo sapiens 105-109 34035828-10 2021 The molecular docking results showed that quercetin, formononetin, kaempferol, isorhamnetin, beta-sitosterol had a good binding activity with VEGFA, IL6, TNF, AKT1, and TP53. Quercetin 42-51 interleukin 6 Homo sapiens 149-152 34035828-10 2021 The molecular docking results showed that quercetin, formononetin, kaempferol, isorhamnetin, beta-sitosterol had a good binding activity with VEGFA, IL6, TNF, AKT1, and TP53. formononetin 53-65 interleukin 6 Homo sapiens 149-152 34983106-5 2022 In vitro, polyinosinic:polycytidylic acid (Poly I-C) treatment markedly enhanced the production of SAA1 from AECs, which was further augmented by neutrophils; SAA1 could induce the production of interleukin (IL)-6, IL-8, and S100 calcium-binding protein A9 from AECs. Poly C 23-41 interleukin 6 Homo sapiens 195-213 33130125-11 2021 One study showed a significant increase in blood interleukin-6 levels among individuals who drank caffeinated coffee, compared to individuals consuming no coffee. caffeinated 98-109 interleukin 6 Homo sapiens 49-62 33432366-0 2021 IL-6 plays a crucial role in epithelial-mesenchymal transition and pro-metastasis induced by sorafenib in liver cancer. Sorafenib 93-102 interleukin 6 Homo sapiens 0-4 33432366-2 2021 However, the role and molecular mechanism of IL-6 in the treatment of sorafenib in liver cancer remain unclear. Sorafenib 70-79 interleukin 6 Homo sapiens 45-49 33432366-3 2021 In the present study, through western blot analysis, Transwell assay, flow cytometric assay, ELISA analysis and immunohistochemistry it was revealed that sorafenib promoted metastasis and induced epithelial-mesenchymal transition (EMT) in liver cancer cells in vitro and in vivo, and significantly increased IL-6 expression. Sorafenib 154-163 interleukin 6 Homo sapiens 308-312 33432366-5 2021 Knocked out IL-6 markedly attenuated the pro-metastasis effect of sorafenib and increased the susceptibility of liver cancer cells to it. Sorafenib 66-75 interleukin 6 Homo sapiens 12-16 33947580-10 2021 And the enhanced TNF-alpha and IL-6 secretion as well as cell cycle arrest by C/EBP beta overexpression were blocked by BAY11-7082 inhibitor of NF-kappaB pathway. 3-(4-methylphenylsulfonyl)-2-propenenitrile 120-130 interleukin 6 Homo sapiens 31-35 2583859-7 1989 HGF activity of TAM supernatants was completely blocked by anti-IL-6 antibodies. tam 16-19 interleukin 6 Homo sapiens 64-68 34006690-8 2021 Low-dose methotrexate (MTX) is effective in decreasing CSF IL-6 levels without promoting the progression of neuropsychological manifestations. Methotrexate 9-21 interleukin 6 Homo sapiens 59-63 34006690-8 2021 Low-dose methotrexate (MTX) is effective in decreasing CSF IL-6 levels without promoting the progression of neuropsychological manifestations. Methotrexate 23-26 interleukin 6 Homo sapiens 59-63 33932293-10 2021 LDNs enhanced autologous T-cell proliferation, IL-6 and IFN-gamma production. ldns 0-4 interleukin 6 Homo sapiens 47-51 33962178-0 2021 A highly selective and stable cationic polyelectrolyte encapsulated black phosphorene based impedimetric immunosensor for Interleukin-6 biomarker detection. Polyelectrolytes 39-54 interleukin 6 Homo sapiens 122-135 33962178-6 2021 The impedimetric immunosensor was developed on a BP-PAMI modified laser burned graphene (LBG) to detect interleukin-6 biomarkers using electrochemical impedance spectroscopy (EIS). NDI-091143 89-92 interleukin 6 Homo sapiens 104-117 33903806-9 2021 Significant positive correlations were observed between metabolites (including pseudouridine, l-phenylalanine, and p-hydroxyphenylacetic acid) and IL-6 levels only in ESRD group. 4-hydroxyphenylacetic acid 115-141 interleukin 6 Homo sapiens 147-151 33935778-10 2021 Activated LPTC from IBD patients showed low proliferative rates and reduced secretion of TNF-alpha, IL-6, IFN-gamma and IL-13 in the presence of L. kefiri. lptc 10-14 interleukin 6 Homo sapiens 100-104 33836651-13 2021 Compared with the C group, the levels of HMGB1, TNF-alpha, and IL-6 were significantly decreased 1 and 3 days after surgery in the QLB group (P < 0.05). N-Octyl(oxyethylene)(3)ethanol 131-134 interleukin 6 Homo sapiens 63-67 33834669-12 2021 Results of qRT-PCR analysis indicated that 0.5 micromol L-1 of sitagliptin and 5 micromol L-1 of BAY11-7082 significantly inhibited LPS-induced IL-6, IL-8, CCL2, and SOD2 gene expressions. 3-(4-methylphenylsulfonyl)-2-propenenitrile 97-107 interleukin 6 Homo sapiens 144-148 33210765-13 2021 LTA-stimulated DPSCs released IL-6 and IL-8 in a dose-dependent manner (P <= 0.0001). lipoteichoic acid 0-3 interleukin 6 Homo sapiens 30-34 33614444-8 2021 In addition, MSC-CMT treatment significantly reduced CD11b+ inflammatory cell infiltration, and inhibited the expression of pro-inflammatory cytokines (IL-1beta, TNF-alpha and IL-6). cmt 17-20 interleukin 6 Homo sapiens 176-180 33592002-12 2021 Finally, sulforaphane significantly inhibited the production of IL-6, TNF-alpha, and IL-17 by human peripheral blood mononuclear cells stimulated with an anti-CD3 monoclonal antibody in a dose-dependent manner. sulforaphane 9-21 interleukin 6 Homo sapiens 64-68 33417258-7 2021 Our data provide the first complete transcriptome for aldosterone on a human renal cell line and identifies pro-inflammatory markers (IL6, IL11, CCL7, and CXCL8) as aldosterone-repressed genes. Aldosterone 165-176 interleukin 6 Homo sapiens 134-137 33146673-7 2021 RESULTS: The network pharmacology research showed that TCM could decrease IL-6 using several compounds, such as quercetin, ursolic acid, luteolin, and rutin. Quercetin 112-121 interleukin 6 Homo sapiens 74-78 33146673-11 2021 Quercetin, ursolic acid, luteolin, and rutin could inhibit COVID-19 by downregulating IL-6. Quercetin 0-9 interleukin 6 Homo sapiens 86-90 33502605-8 2021 Additionally, the elevated pro-inflammatory cytokine levels were counteracted after aloin treatment in cells under SI/R conditions, including TNF-alpha, IL-6, and IL-1beta. alloin 84-89 interleukin 6 Homo sapiens 153-157 33481950-8 2021 In human peripheral blood mononuclear cells, SAP attenuated ORN06-induced extracellular accumulation of IL-6. orn06 60-65 interleukin 6 Homo sapiens 104-108 32008984-0 2021 5-Azacytidine restores interleukin 6-increased production in mesenchymal stromal cells from myelodysplastic patients. Azacitidine 0-13 interleukin 6 Homo sapiens 23-36 32008984-16 2021 The in vitro 5-Azacytidine treatment induced a significant decrease in the IL-6 production by MDS-MSC. Azacitidine 13-26 interleukin 6 Homo sapiens 75-79 32008984-18 2021 The in vitro treatment with 5-Azacytidine lead to a significant reduction in the IL-6 production by the MDS-MSC, restoring the IL-6 levels to those found in controls. Azacitidine 28-41 interleukin 6 Homo sapiens 81-85 32008984-18 2021 The in vitro treatment with 5-Azacytidine lead to a significant reduction in the IL-6 production by the MDS-MSC, restoring the IL-6 levels to those found in controls. Azacitidine 28-41 interleukin 6 Homo sapiens 127-131 32077313-4 2021 PolyP-induced NF-kappaB activation and the productions of TNF-alpha and IL-6 were inhibited by aloin in HUVECs. alloin 95-100 interleukin 6 Homo sapiens 72-76 33437169-6 2021 Results: The treatment with pCA suppressed the productions and mRNA expressions of thymic stromal lymphopoietin (TSLP), TNF-alpha, IL-6, and IL-1beta in HMC-1 cells. p-coumaric acid 28-31 interleukin 6 Homo sapiens 131-135 32931836-3 2020 In this research, nucleic acid aptamer LA27, which was previously selected and optimized by our group, was used as an LPS inhibitor to treat human HepG2 cells stimulated by LPS from four different sources (StLPS, EcoliLPS, PaLPS, and SeLPS): the levels of expression of three inflammatory cytokines factors (TNF-alpha, IL-1beta, and IL-6) were evaluated by ELISA on LA27-treated and untreated cells incubated for 12 h with LPS. la27 39-43 interleukin 6 Homo sapiens 333-337 33520015-11 2020 Finally, 6 key proteins of TNF, IL-10, IL-2, IL-6, STAT1 and CCL2 were selected and successfully docked with 4 active ingredients of quercetin, luteolin, wogonin and kaempferol. Quercetin 133-142 interleukin 6 Homo sapiens 45-49 33049493-8 2020 Our results showed that trelagliptin inhibited the expression of pro-inflammatory chemokines including monocyte chemoattractant protein 1 (MCP-1), CXCL-1, and IL-6. trelagliptin 24-36 interleukin 6 Homo sapiens 159-163 33096361-4 2020 In in-vitro experiments, the protective effect of aloin on the anabolism and catabolism of the extracellular matrix (ECM) induced by IL-1 beta in chondrocytes by inhibiting the expression of pro-inflammatory factors, including TNF-alpha (p = 0.016), IL-6 (p = 0.006), iNOS (p = 0.001) and COX-2 (p = 0.006). alloin 50-55 interleukin 6 Homo sapiens 250-254 32835879-7 2020 Further, PDT with 5 muM methylene blue was observed to be able to promote the migration of HGFs especially the healthy state, and increases the expression of wound healing related genes including IL-6, COL1, FN, bFGF in healthy and inflamed HGFs (P < 0.05). Methylene Blue 24-38 interleukin 6 Homo sapiens 196-200 33255431-6 2020 IL-6 release was inhibited by P2X7R antagonists A438079, A839977, and AZ10606120, but not the NRTI lamivudine (3TC), P2X1R antagonist NF279, or P2Y1R antagonist MRS2179. AZ10606120 70-80 interleukin 6 Homo sapiens 0-4 33255431-6 2020 IL-6 release was inhibited by P2X7R antagonists A438079, A839977, and AZ10606120, but not the NRTI lamivudine (3TC), P2X1R antagonist NF279, or P2Y1R antagonist MRS2179. N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate 161-168 interleukin 6 Homo sapiens 0-4 32950532-4 2020 VITROCELL cloud chamber exposure of BEAS-2B monolayers increased mitochondrial protein oxidation, expression of the antioxidant enzyme SOD2, activation of NF-kappaB, and secretion of inflammatory cytokines (IL-6 and IL-8). beas 37-41 interleukin 6 Homo sapiens 208-212 33204288-12 2020 Molecular docking showed that quercetin, kaempferol, baicalein, and wogonin have good binding activity with IL6, VEGFA, EGFR, and NFKBIA targets. Quercetin 30-39 interleukin 6 Homo sapiens 108-111 33332480-3 2020 Upadacitinib tartrate (Rinvoq), a selective and reversible JAK1 inhibitor, inhibited interleukin (IL)-6 and IL-7 and ameliorated adjuvant-induced arthritis in preclinical studies. Upadacitinib tartrate 0-21 interleukin 6 Homo sapiens 85-103 32898874-7 2020 However, an inhibitory effect of the identified quercetin-3-O-rhamnoside and its aglycone, quercetin, on the release of IL-8 and IL-6 could not be demonstrated. Quercetin 48-57 interleukin 6 Homo sapiens 129-133 33114438-13 2020 As a result, we identified that Ac2-26 significantly decreased the expression of TNF-alpha/IFN-gamma-stimulated pro-inflammatory chemokines, including IL-1beta, IL-6, IL-8, MDC, TARC, and TNF-alpha, by inhibiting the activation of MAPK, NF-kappaB, and JAK/STAT pathway in TNF-alpha/IFN-gamma-stimulated HaCaT human keratinocytes. annexin A1 peptide (2-26) 32-38 interleukin 6 Homo sapiens 161-165 33110480-5 2020 RESULTS: High IL-6, IL-1beta and TNFRI levels were found in PMC and NC exposed to talc. Talc 82-86 interleukin 6 Homo sapiens 14-18 33155234-0 2020 Observation of the efficacy of naloxone combined with acyclovir in the treatment of children viral encephalitis and its impacts on IL-1 and IL-6. Acyclovir 54-63 interleukin 6 Homo sapiens 140-144 33155234-13 2020 CONCLUSIONS: In the treatment of children, viral encephalitis has naloxone combined with ganciclovir had a more significant effect on the decrease of levels of serum IL-1 and IL-6; naloxone combined with acyclovir in the treatment of children viral encephalitis had better effects, lower adverse reactions and lower prevalence of sequelae compared with sole medication, which is worth clinical promotion. Acyclovir 204-213 interleukin 6 Homo sapiens 175-179 33289658-9 2020 In post-hoc analyses, associations between baseline IL-6 levels and symptom reduction were strongest in patients treated with either ziprasidone or quetiapine. Quetiapine Fumarate 148-158 interleukin 6 Homo sapiens 52-56 32967164-5 2020 ST2825 significantly downregulates the production of IFN-gamma, IL-6, IL-12, IL-2, IL-15, IL-7, VEGF, IL-1Ra, IL-4, IL-5, IL-13 and IL-9 (p < 0.05) in LPS-stimulated PBMC. ST2825 0-6 interleukin 6 Homo sapiens 64-68 32957884-5 2021 Previous studies have shown that quercetin reduces the entry of the virus into the cell by blocking the ACE2 receptor, as well as reducing the level of interleukin-6 in SARS and MERS patients. Quercetin 33-42 interleukin 6 Homo sapiens 152-165 33065791-4 2020 The goal of this study was to investigate the clinical effect of xipayi mouth rinse combined with minocycline in the treatment of localized aggressive periodontitis and its effect on the levels of CRP, TNF-alpha, and IL-6. Minocycline 98-109 interleukin 6 Homo sapiens 217-221 31907296-12 2020 In two IHCA, we identified truncated 3"UTR of IL6 associated with overexpression of the transcript. 2-(4-imidazoyl)hydrocinnamic acid 7-11 interleukin 6 Homo sapiens 46-49 32003289-15 2020 CONCLUSION: The use of Cytosorb in combination with Continuous Renal Replacement Therapy as blood purification strategy in pediatric septic shock is associated with a rapid hemodynamic stabilization in the first 48 h of treatment and a significant reduction of interleukin-6 and interleukin-10. cytosorb 23-31 interleukin 6 Homo sapiens 261-274 32394409-7 2020 During PMMA hemofiltration, the CL of IL-6 peaked at 31 +- 76 mL/min, with no relationship observed between the CL and isoelectric point. Polymethyl Methacrylate 7-11 interleukin 6 Homo sapiens 38-42 32620010-7 2020 Higher EtFOSAA concentrations were also associated with 10.8% higher IL-6 (95%CI: 3.3, 18.9) and 6.1% lower SHBG (95%CI: 0.7, 11.2) per doubling. EtFOSAA 7-14 interleukin 6 Homo sapiens 69-73 32464779-4 2020 Urinary metabolites of PAHs (i.e., OH-PAHs), measured as indicators of total PAH exposure, showed significant associations with markers of respiratory and systemic inflammation, including exhaled nitric oxide, interleukin (IL)-6 in exhaled breath condensate, and blood IL-2 and IL-8 levels and leucocyte count. Polycyclic Aromatic Hydrocarbons 23-26 interleukin 6 Homo sapiens 210-228 32504994-9 2020 In phorbol myristate acetate (PMA)-stimulated A549 or H292 airway epithelial cells, pretreatment of THCA dose-dependently inhibited the generation of IL-6. thca 100-104 interleukin 6 Homo sapiens 150-154 32792961-4 2020 Both TRYP and TRYP-Ox inhibited matrix metalloproteinase (MMP)-3 gene expression in interleukin (IL)-1beta-stimulated primary human FLS, as well as IL-1beta-induced secretion of MMP-1/3 by FLS and synovial SW982 cells and IL-6 by FLS, SW982 cells, human umbilical vein endothelial cells (HUVECs), and monocytic THP-1 cells, although TRYP-Ox was generally more effective and had no cytotoxicity in vitro. tryptanthrine 5-9 interleukin 6 Homo sapiens 222-226 32792961-4 2020 Both TRYP and TRYP-Ox inhibited matrix metalloproteinase (MMP)-3 gene expression in interleukin (IL)-1beta-stimulated primary human FLS, as well as IL-1beta-induced secretion of MMP-1/3 by FLS and synovial SW982 cells and IL-6 by FLS, SW982 cells, human umbilical vein endothelial cells (HUVECs), and monocytic THP-1 cells, although TRYP-Ox was generally more effective and had no cytotoxicity in vitro. tryptanthrine 14-18 interleukin 6 Homo sapiens 222-226 32223225-5 2020 Our in vitro data demonstrate an increase in pro-inflammatory cytokines IL-6 and IL-8 levels in response to vaped PG and GLY exposures. Propylene Glycol 114-116 interleukin 6 Homo sapiens 72-76 32223225-5 2020 Our in vitro data demonstrate an increase in pro-inflammatory cytokines IL-6 and IL-8 levels in response to vaped PG and GLY exposures. Glycerol 121-124 interleukin 6 Homo sapiens 72-76 32223225-7 2020 Additionally, we find that the exposure of vaped PG causes elevated IL-6 expression while the exposure of vaped GLY increases These findings suggest that vaporizing PG and GLY results in the formation of novel compounds and the exposure of vaped PG and GLY are detrimental to airway cells. Propylene Glycol 49-51 interleukin 6 Homo sapiens 68-72 32223225-7 2020 Additionally, we find that the exposure of vaped PG causes elevated IL-6 expression while the exposure of vaped GLY increases These findings suggest that vaporizing PG and GLY results in the formation of novel compounds and the exposure of vaped PG and GLY are detrimental to airway cells. Propylene Glycol 165-167 interleukin 6 Homo sapiens 68-72 32223225-7 2020 Additionally, we find that the exposure of vaped PG causes elevated IL-6 expression while the exposure of vaped GLY increases These findings suggest that vaporizing PG and GLY results in the formation of novel compounds and the exposure of vaped PG and GLY are detrimental to airway cells. Glycerol 172-175 interleukin 6 Homo sapiens 68-72 32223225-7 2020 Additionally, we find that the exposure of vaped PG causes elevated IL-6 expression while the exposure of vaped GLY increases These findings suggest that vaporizing PG and GLY results in the formation of novel compounds and the exposure of vaped PG and GLY are detrimental to airway cells. Propylene Glycol 165-167 interleukin 6 Homo sapiens 68-72 32223225-7 2020 Additionally, we find that the exposure of vaped PG causes elevated IL-6 expression while the exposure of vaped GLY increases These findings suggest that vaporizing PG and GLY results in the formation of novel compounds and the exposure of vaped PG and GLY are detrimental to airway cells. Glycerol 172-175 interleukin 6 Homo sapiens 68-72 32707735-9 2020 Treatment with adenine suppressed TNF-alpha-induced elevation in IL-6 expression and nitrite oxide production in MG-63 cells. Adenine 15-22 interleukin 6 Homo sapiens 65-69 32440348-2 2020 The combined effect of Cit, GlcN and GlcNAc on synovial cell inflammation was assessed by measuring IL-1beta-induced IL-6 production. Acetylglucosamine 37-43 interleukin 6 Homo sapiens 117-121 32440348-4 2020 Furthermore, the combined effect of Cit, GlcNAc and GlcN was examined; Cit + GlcN and Cit + GlcNAc significantly suppressed not only IL-6 production, but also phosphorylation of ERK1/2. Acetylglucosamine 41-47 interleukin 6 Homo sapiens 133-137 32440348-4 2020 Furthermore, the combined effect of Cit, GlcNAc and GlcN was examined; Cit + GlcN and Cit + GlcNAc significantly suppressed not only IL-6 production, but also phosphorylation of ERK1/2. Acetylglucosamine 92-98 interleukin 6 Homo sapiens 133-137 32440348-5 2020 Similarly, combination of GlcN + GlcNAc significantly suppressed IL-6 production and phosphorylation of ERK1/2. Acetylglucosamine 33-39 interleukin 6 Homo sapiens 65-69 32361974-3 2020 The results showed that endosulfan could induce inflammatory response and dysfunction by increasing the release of inflammatory cytokines such as interleukin-1beta (IL-1beta), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and adhesion molecules such as vascular cell adhesion molecule 1 (VCAM-1) and endothelin-1 (ET-1), and inducing ROS production in HUVECs. Endosulfan 24-34 interleukin 6 Homo sapiens 176-189 32361974-3 2020 The results showed that endosulfan could induce inflammatory response and dysfunction by increasing the release of inflammatory cytokines such as interleukin-1beta (IL-1beta), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and adhesion molecules such as vascular cell adhesion molecule 1 (VCAM-1) and endothelin-1 (ET-1), and inducing ROS production in HUVECs. Endosulfan 24-34 interleukin 6 Homo sapiens 191-195 32458964-6 2020 In addition, Nar significantly counteracted MTX-induced increases in hepatic interleukin-6 and tumor necrosis factor-alpha. Methotrexate 44-47 interleukin 6 Homo sapiens 77-90 31954113-1 2020 CRISPR-Cas9 engineered CYBBko THP-1 cell lines display an inflammatory profile with increased IL-1beta, IL-6 and TNF-alpha secretion as consequence of NADPH-induced ROS deficiency. NADP 151-156 interleukin 6 Homo sapiens 104-108 32179074-3 2020 KEY FINDINGS: Pre-treatment with quercetin significantly reversed the LPS-induced upregulation of pro-fibrotic factors (IL-6, IL-8, COL-1, COL-3, LC3) and fibrotic signaling mediators (mTOR and AKT), and it induced the downregulation of ATG5 in the WI-38 cells. Quercetin 33-42 interleukin 6 Homo sapiens 120-124 32336102-7 2020 With almost equal surface content of PSBMA, the PSBMA-PDA-PP exhibited a more superior ability against macrophages adhesion and proliferation, and showed more significantly decreased releases of TNF-alpha and IL-6 (p < 0.05) than those of PSBMA@PDA-PP, fundamentally attributed to its more neutral surface potential and the protection for polyphenols of PDA from oxidation with PSBMA as the outer-layer. polydopamine 54-57 interleukin 6 Homo sapiens 209-213 32477333-10 2020 Furthermore, the partially demannosylated and partially desialylated N-glycans showed stronger inhibition of IL-6 production compared with the native N-glycans. n-glycans 69-78 interleukin 6 Homo sapiens 109-113 32477333-10 2020 Furthermore, the partially demannosylated and partially desialylated N-glycans showed stronger inhibition of IL-6 production compared with the native N-glycans. n-glycans 150-159 interleukin 6 Homo sapiens 109-113 32477333-12 2020 Compared to CQN, the N-glycans are specific inhibitors of TLR-8 activation and of IL-6 production in MoDCs. n-glycans 21-30 interleukin 6 Homo sapiens 82-86 31804760-12 2020 Meanwhile, Quercetin attenuated LPS-stimulated apoptosis, production of IL-6, and TNF-alpha in experimental cells. Quercetin 11-20 interleukin 6 Homo sapiens 72-76 31960917-6 2020 Pre-treating ARPE-19 cells with quercetin clearly attenuated high glucose-induced viability loss, apoptosis, MCP-1 and IL-6 overproduction, and ROS generation. Quercetin 32-41 interleukin 6 Homo sapiens 119-123 32346326-0 2020 Spiroindolone analogues bearing benzofuran moiety as a selective cyclooxygenase COX-1 with TNF-alpha and IL-6 inhibitors. benzofuran 32-42 interleukin 6 Homo sapiens 105-109 32440094-6 2020 Methods: The effects of laquinimod on the gene expression of IL-6, MCP-1, VCAM-1, E-selectin, and KLF2 were measured by real-time PCR. laquinimod 24-34 interleukin 6 Homo sapiens 61-65 32440094-10 2020 Results: Our findings demonstrate that laquinimod reduced the expression of key inflammatory cytokines and chemokines, including IL-6, MCP-1, and HMGB1. laquinimod 39-49 interleukin 6 Homo sapiens 129-133 32425545-9 2020 We found that M2-like TAMs promoted the invasion, migration, and angiogenesis of HNSCC cells; however, DHA significantly inhibited IL-4/IL-6-induced M2 macrophage polarization. artenimol 103-106 interleukin 6 Homo sapiens 136-140 32032644-0 2020 Honokiol: A polyphenol neolignan ameliorates pulmonary fibrosis by inhibiting TGF-beta/Smad signaling, matrix proteins and IL-6/CD44/STAT3 axis both in vitro and in vivo. honokiol 0-8 interleukin 6 Homo sapiens 123-127 32005665-8 2020 In hypoxia mimicked by treating MDM with oligomycin (a mitochondrial ATP synthase inhibitor), both 2-DG and glucose starvation strongly suppress TNF and interleukin-6 production, and compromise cell viability. oligomycin A 41-51 interleukin 6 Homo sapiens 153-166 31513749-0 2020 PI3K Catalytic Subunits alpha and beta Modulate Cell Death and IL-6 Secretion Induced by Talc Particles in Human Lung Carcinoma Cells. Talc 89-93 interleukin 6 Homo sapiens 63-67 31513749-3 2020 Here, we report a study of the signaling pathways that can modulate the cell death and IL-6 secretion induced by talc particles in human lung carcinoma cells. Talc 113-117 interleukin 6 Homo sapiens 87-91 31758423-9 2020 IGU, MTX, and DXM dose dependently decreased the secretion of TNF-alpha, IL-1beta, IL-6, and IL-8 in neutrophils and PBMCs (P < 0.05); the inhibitory effect of IGU was not significantly different from that of MTX and DXM. Methotrexate 5-8 interleukin 6 Homo sapiens 83-87 31879859-9 2020 ELISA assay showed that miR-150-5p mimics increased interleukin-6 level in the cell culture medium but did not influence tumor necrosis factor-alpha levels. mir-150-5p 24-34 interleukin 6 Homo sapiens 52-65 31879859-12 2020 miR-150-5p increased the secretion of IL-6 but did not significantly affect TNF-alpha levels in MH7A cells. mir-150-5p 0-10 interleukin 6 Homo sapiens 38-42 32068951-7 2020 Pro-B3 pre-treatment inhibited LPS-induced production of inflammation correlated factors such as tumour necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), prostaglandin E2 (PGE2) and Nitric oxide (NO). procyanidin B3 0-6 interleukin 6 Homo sapiens 139-152 32068951-7 2020 Pro-B3 pre-treatment inhibited LPS-induced production of inflammation correlated factors such as tumour necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), prostaglandin E2 (PGE2) and Nitric oxide (NO). procyanidin B3 0-6 interleukin 6 Homo sapiens 154-158 31822925-9 2020 RESULTS: 5-methoxy-N,N-dimethyltryptamine significantly increased cortisol levels and decreased IL-6 concentrations in saliva immediately post-session. Methoxydimethyltryptamines 9-41 interleukin 6 Homo sapiens 96-100 32117213-6 2019 The relative expression and secretion of IL-6, IL-8, and TNF-alpha in lipopolysaccharide-stimulated microglia were up-regulated in the GSC supernatant group, which could be reversed by dimethyl amiloride (DMA) (EV secretion inhibitor) co-administration or si-MALAT1 pre-transfection of GSCs. 5-dimethylamiloride 185-203 interleukin 6 Homo sapiens 41-45 32117213-6 2019 The relative expression and secretion of IL-6, IL-8, and TNF-alpha in lipopolysaccharide-stimulated microglia were up-regulated in the GSC supernatant group, which could be reversed by dimethyl amiloride (DMA) (EV secretion inhibitor) co-administration or si-MALAT1 pre-transfection of GSCs. 5-dimethylamiloride 205-208 interleukin 6 Homo sapiens 41-45 31769560-9 2020 Pretreatment with BAY 11-7082 significantly inhibited vibration-induced IL-6 and IL-8 mRNA and protein expression in hPDL cells. 3-(4-methylphenylsulfonyl)-2-propenenitrile 18-29 interleukin 6 Homo sapiens 72-76 31935362-5 2020 In addition, the increased levels of TNF-alpha, IL-6 and IL-1beta in OGD/R-induced hippocampal neurons were significantly decreased by trigonelline pretreatment. trigonelline 135-147 interleukin 6 Homo sapiens 48-52 32461931-0 2020 Comparison of Efficacy between Clopidogrel and Ticagrelor in Patients with Acute Coronary Syndrome after Interventional Treatment and Their Effects on IL-6. Clopidogrel 31-42 interleukin 6 Homo sapiens 151-155 32461931-1 2020 Background: We aimed to compare the efficacy between clopidogrel and ticagrelor in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI) and their effects on IL-6. Clopidogrel 53-64 interleukin 6 Homo sapiens 195-199 31991717-4 2020 In our experimental model, main carnosine beneficial effects were: (1) the modulation of nitric oxide production and metabolism; (2) the amelioration of the macrophage energy state; (3) the decrease of the expressions of pro-oxidant enzymes (Nox-2, Cox-2) and of the lipid peroxidation product malondialdehyde; (4) the restoration and/or increase of the expressions of antioxidant enzymes (Gpx1, SOD-2 and Cat); (5) the increase of the transforming growth factor-beta1 (TGF-beta1) and the down-regulation of the expressions of interleukins 1beta and 6 (IL-1beta and IL-6) and 6) the increase of the expressions of Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and heme oxygenase-1 (HO-1). Carnosine 32-41 interleukin 6 Homo sapiens 566-577 31825793-12 2020 Upregulation of miR-345-3p impeded oxLDL-induced growth inhibition, lactate dehydrogenase leakage, apoptosis, and expression of TNF-alpha, IL-6, ICAM-1, VCAM-1, and E-selectin. mir-345-3p 16-26 interleukin 6 Homo sapiens 139-143 31678878-8 2020 Blood Pb levels were negatively correlated with salivary sialic acids, in which IL-6 played as a mediator of the association between blood Pb levels and saliva sialic acid concentrations according to the mediation model. Sialic Acids 57-69 interleukin 6 Homo sapiens 80-84 31678878-8 2020 Blood Pb levels were negatively correlated with salivary sialic acids, in which IL-6 played as a mediator of the association between blood Pb levels and saliva sialic acid concentrations according to the mediation model. Sialic Acids 57-68 interleukin 6 Homo sapiens 80-84 31497913-5 2020 The results demonstrated that quercetin can significantly inhibit expression and secretion of IL-1beta, IL-6, and TNF-alpha in LPS-induced bone marrow-derived macrophages (BMDMs) and reduce activity of Mincle/Syk/NF-kappaB signaling in vitro. Quercetin 30-39 interleukin 6 Homo sapiens 104-108 31497913-6 2020 We also found that quercetin can strongly reduce the concentration of serum creatinine, BUN, IL-1beta, IL-6, and TNF-alpha in cisplatin-induced AKI model. Quercetin 19-28 interleukin 6 Homo sapiens 103-107 31102177-7 2020 Glu and Asp supplementation also modulated the expression of TGF-beta1, IL-10, TNF-alpha, IL-6 and IL-1beta in the testis and epididymis. Aspartic Acid 8-11 interleukin 6 Homo sapiens 90-94 31888128-5 2019 The effect of the extracts, diosmin, 1-octen-3-ol on the secretion of pro-inflammatory cytokines, IL-6 (A) and IL-8 (B) by human dermal fibroblasts was significant (p < 0.001). 1-octen-3-ol 37-49 interleukin 6 Homo sapiens 98-102 31610186-5 2019 Quercetin caused further increase in LPS-induced IL-6 and IL-8 levels. Quercetin 0-9 interleukin 6 Homo sapiens 49-53 31836774-4 2019 However, these effects were prevented by the IRE1 endonuclease inhibitor STF083010 since it time-dependently reduced IL-1beta-induced Xbp1 mRNA splicing, XBP1s protein expression, inflammatory factor IL-6 secretion and the expression of the fibrotic marker fibronectin in human peritoneal mesothelial cells (HPMCs). STF 083010 73-82 interleukin 6 Homo sapiens 200-204 31733592-6 2019 This was demonstrated using the argininocalix[4]arene 1 in miRNA therapeutic approaches performed on three well-described experimental model systems: (1) the induction of apoptosis by antimiR-221 in glioma U251 cells; (2) the induction of apoptosis by premiR-124 in U251 cells; and (3) the inhibition of pro-inflammatory IL-8 and IL-6 genes in cystic fibrosis IB3-1 cells. calix(4)arene 32-53 interleukin 6 Homo sapiens 330-334 31612365-4 2019 Therefore, the aim of the study was to investigate influence of NADPH oxidase inhibition on the expression of IL-6, IL-8, TNF, TSLP, CD59, and PPAR-gamma in vitro. NADP 64-69 interleukin 6 Homo sapiens 110-114 31612365-8 2019 The time-response and dose-response study showed that apocynin significantly influenced the relative expression of chosen genes (IL-6, IL-8, TNF, PPAR-gamma, TSLP, and CD59). acetovanillone 54-62 interleukin 6 Homo sapiens 129-133 31612365-9 2019 Apocynin decreased the mRNA expression of TNF-alpha at all concentrations used, and of IL-6 at concentrations of 1 and 3 mg/ml (p < 0.05). acetovanillone 0-8 interleukin 6 Homo sapiens 87-91 30953364-7 2019 Effect of SDF-1alpha-induced upregulation of IL-6 on chemotherapeutic resistance and apoptosis of RPMI-8226 cells in adhesion state was analyzed. 1alpha 14-20 interleukin 6 Homo sapiens 45-49 31604428-7 2019 Dexmedetomidine added to ropivacaine for transversus abdominis plane block significantly reduced serum levels of cortisol, norepinephrine, epinephrine, interleukin-6, blood glucose, mean arterial pressure and heart rate in a dose-dependent manner (P < 0.05), accompanied with decreased anesthetic and opioid consumption during the operation (P < 0.05), but the high dose of dexmedetomidine induced higher incidences of bradycardia than low or medium dose of dexmedetomidine (P < 0.05). ropivacaine 25-36 interleukin 6 Homo sapiens 152-165 31377467-6 2019 In in vitro, minocycline reduced cytopathic effects (CPEs), viral protein expressions, viral titers, the levels of interleukin (IL)-6 and IL-8 and relative mRNA expressions of IL-12p40, IL-1beta, and tumor necrosis factor (TNF) after EV71 infection. Minocycline 13-24 interleukin 6 Homo sapiens 115-133 31377467-7 2019 The levels of TNF, IL-1beta, IL-6, and IL-8 decreased with a single dose of minocycline in EV71-infected THP-1 cells. Minocycline 76-87 interleukin 6 Homo sapiens 29-33 31377467-10 2019 Minocycline inhibited IL-6 and granulocyte colony-stimulating factor (G-CSF) in plasma and TNF in the cerebellum. Minocycline 0-11 interleukin 6 Homo sapiens 22-26 31387809-0 2019 Decreased IL-6 induces sensitivity of hepatocellular carcinoma cells to sorafenib. Sorafenib 72-81 interleukin 6 Homo sapiens 10-14 31387809-3 2019 Therefore, in the present study, we attempted to investigate the effect and mechanisms of IL-6 on sensitivity of HCC cells to sorafenib regarding the cell proliferation and apoptosis. Sorafenib 126-135 interleukin 6 Homo sapiens 90-94 31387809-7 2019 Furthermore, sorafenib significantly inhibited cell proliferation, IL-6 level and activation of p-PI3K/AKT while promoted the cell apoptosis rate and Caspase3 level compared as the control group, which were further promoted by administration of si IL-6. Sorafenib 13-22 interleukin 6 Homo sapiens 67-71 31387809-7 2019 Furthermore, sorafenib significantly inhibited cell proliferation, IL-6 level and activation of p-PI3K/AKT while promoted the cell apoptosis rate and Caspase3 level compared as the control group, which were further promoted by administration of si IL-6. Sorafenib 13-22 interleukin 6 Homo sapiens 248-252 31387809-8 2019 Therefore, downregulating IL-6 could be a potential treatment to increase the cell sensitivity of HCC cells to sorafenib. Sorafenib 111-120 interleukin 6 Homo sapiens 26-30 31162616-8 2019 Furthermore, the 5-methylcytosine level of the CpG island in the promoter region of IL-6 and interferon regulatory factor 7 (IRF7) were determined. 5-Methylcytosine 17-33 interleukin 6 Homo sapiens 84-88 31416745-7 2019 The amelioration of cognitive deficits with minocycline correlated not only with the remission of negative symptoms, but also with the reduction in serum levels of IL-1beta and IL-6. Minocycline 44-55 interleukin 6 Homo sapiens 177-181 30676542-1 2019 OBJECTIVE: The main objectives of this article were to assess the effect of preoperative transdermal fentanyl patch (TFP) on interleukin (IL)-6 and IL-8 levels and pain after laparoscopic cholecystectomy. Fentanyl 101-109 interleukin 6 Homo sapiens 125-143 31337650-11 2019 SIGNIFICANCE: IL6 promotes STAT3-dependent transcriptional upregulation of PRL-3, which in turn re-phosphorylates STAT3 and aberrantly activates STAT3 target genes, leading to bortezomib resistance in multiple myeloma. Bortezomib 176-186 interleukin 6 Homo sapiens 14-17 31228705-4 2019 Owing to the ROS scavenging ability of quercetin, Qu-FeIIP effectively reduces intracellular ROS and in vivo inflammatory factors (TNF-alpha, IL-6, IFN-gamma) levels. Quercetin 39-48 interleukin 6 Homo sapiens 142-146 31309323-8 2019 IL-6 serum levels were lower at the analysed postoperative time points in the CHO group (p < 0.001). cho 78-81 interleukin 6 Homo sapiens 0-4 31344398-7 2019 Moreover, minocycline decreased the production of inflammatory mediators including TNF, IL-6, and MMP-9, by microglia. Minocycline 10-21 interleukin 6 Homo sapiens 88-92 31383893-0 2019 Niclosamide reverses adipocyte induced epithelial-mesenchymal transition in breast cancer cells via suppression of the interleukin-6/STAT3 signalling axis. Niclosamide 0-11 interleukin 6 Homo sapiens 119-132 31383893-8 2019 Additionally, niclosamide reversed adipocyte-induced EMT with a correlated inhibition of IL-6/Stat3 activation and downregulation of EMT-TFs TWIST and SNAIL. Niclosamide 14-25 interleukin 6 Homo sapiens 89-93 30612216-9 2019 In addition, ATO suppressed the angiogenic ability in TNBC by inhibiting the interaction of the enhancer of zeste homolog 2 (EZH2) with p65, downregulating the nuclear factor-kappaB (NF-kappaB) activity, hence contributing to the regulation of IL-6/Stat3 signaling pathway. Arsenic Trioxide 13-16 interleukin 6 Homo sapiens 244-248 30884982-8 2019 Travatan and Lumigan 0.03% increased concentrations of Interleukin (IL)-6 and IL-8 in culture media. Travoprost 0-8 interleukin 6 Homo sapiens 55-73 31130368-7 2019 Furthermore, IL-6 and TNF-alpha were responsible for the upregulation of miR-34a and downregulation of Foxp3, which was reverted by the addition of NF-kappaB/p65 inhibitor BAY11-7082, thus indicating that NF-kappaB/p65 inhibited Foxp3 expression in an miR-34a-dependent manner. 3-(4-methylphenylsulfonyl)-2-propenenitrile 172-182 interleukin 6 Homo sapiens 13-17 31091864-3 2019 Among the prepared thienopyrimidine derivatives, 6Aa, 6Ab, 6Ba and 6Bc significantly suppressed the phosphorylation of STAT3 and ERK1/2 stimulated by IL-6 in Hep3B cells. 6aa 49-52 interleukin 6 Homo sapiens 150-154 31212975-5 2019 The results showed that quercetin could dose-dependently decrease the mRNA and protein levels of ICAM-1, IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1). Quercetin 24-33 interleukin 6 Homo sapiens 105-109 31212975-10 2019 An NF-kappaB inhibitor (Bay 11-7082) also reduced the expression of ICAM-1, sICAM-1, IL-6, IL-8 and MCP-1. 3-(4-methylphenylsulfonyl)-2-propenenitrile 24-35 interleukin 6 Homo sapiens 85-89 30913494-9 2019 In the CIA model, the MTX nanogel significantly ameliorated hind paw swelling, reduced arthritic score, joint damage (histological, radiological examination) and attenuated the rise in serum cytokines such as TNF-alpha and IL-6. Methotrexate 22-25 interleukin 6 Homo sapiens 223-227 31155798-6 2019 Kaempferitrin decreased the levels of interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha, matrix metalloproteinase (MMP)-1, and MMP-3 in MH7A cells. lespenefril 0-13 interleukin 6 Homo sapiens 62-66 31101850-11 2019 Patients on methotrexate or anti-TNF therapy produced significantly lower levels of TNF-alpha, IL-10, and IL-6. Methotrexate 12-24 interleukin 6 Homo sapiens 106-110 30615197-0 2019 Novel small molecule IL-6 inhibitor suppresses autoreactive Th17 development and promotes Treg development. th17 60-64 interleukin 6 Homo sapiens 21-25 30615197-0 2019 Novel small molecule IL-6 inhibitor suppresses autoreactive Th17 development and promotes Treg development. treg 90-94 interleukin 6 Homo sapiens 21-25 30615197-8 2019 Together, these data demonstrate that these novel small molecule IL-6 inhibitors have the potential to shift the Teff : Treg balance, which may provide a novel therapeutic strategy for ameliorating disease progression in MS. treg 121-125 interleukin 6 Homo sapiens 65-69 30623574-7 2019 Both Erlotinib (Tarceva) and Osimertinib (AZD-9291) reduced the levels of HDM-stimulated IL-6 and IL-8 levels in BEAS-2B cells. osimertinib 42-50 interleukin 6 Homo sapiens 89-93 30623574-10 2019 Our findings highlight EGFR-TKIs, Tarceva, and AZD-9291, attenuate HDM-induced inflammatory IL-6 and IL-8 cytokines via EGFR signaling axis pathway, but not AMPK signaling pathway. osimertinib 47-55 interleukin 6 Homo sapiens 92-96 30724633-11 2019 IL-1beta and IL-6 were induced by nano-SiO2, and the IL-1beta treatment with 20 muM of I-kappaBalpha phosphorylation inhibitor (PD98059) and 20 muM of ERK1/2 inhibitor (BAY11-7082) for 1 h was significantly lower than that of the control group in A549 cells. 3-(4-methylphenylsulfonyl)-2-propenenitrile 169-179 interleukin 6 Homo sapiens 13-17 30887238-1 2019 A physiologically based pharmacokinetic (PBPK) model was used to simulate the impact of elevated levels of interleukin (IL)-6 on the exposure of several orally administered cytochrome P450 (CYP) probe substrates (caffeine, S-warfarin, omeprazole, dextromethorphan, midazolam, and simvastatin). Warfarin 223-233 interleukin 6 Homo sapiens 107-125 30887238-1 2019 A physiologically based pharmacokinetic (PBPK) model was used to simulate the impact of elevated levels of interleukin (IL)-6 on the exposure of several orally administered cytochrome P450 (CYP) probe substrates (caffeine, S-warfarin, omeprazole, dextromethorphan, midazolam, and simvastatin). Midazolam 265-274 interleukin 6 Homo sapiens 107-125 31406922-3 2019 Aim: To study the effects of PCD on serum levels of C-reactive protein (CRP), IL-6, and IL-10 and its correlation with the outcome. pcd 29-32 interleukin 6 Homo sapiens 78-82 31406922-13 2019 Percentage decrease in IL-6 on day 3 and CRP on day 7 correlated with the outcome of patients managed with PCD. pcd 107-110 interleukin 6 Homo sapiens 23-27 30961685-0 2019 Micheliolide inhibits gastric cancer growth in vitro and in vivo via blockade of the IL-6/STAT3 pathway. micheliolide 0-12 interleukin 6 Homo sapiens 85-89 31435158-2 2019 20 known inhibitors towards IL-6 were screened and Methotrexate (MTX) having PubChem ID: 126941 showed high binding capacity with the receptor IL-6. Methotrexate 65-68 interleukin 6 Homo sapiens 28-32 31435158-2 2019 20 known inhibitors towards IL-6 were screened and Methotrexate (MTX) having PubChem ID: 126941 showed high binding capacity with the receptor IL-6. Methotrexate 65-68 interleukin 6 Homo sapiens 143-147 30881912-8 2019 Results: T-correlation analysis showed that in both ropivacaine and bupivacaine groups, the TNF-alpha, IL-6, and IL-1 levels decreased after the block. Bupivacaine 68-79 interleukin 6 Homo sapiens 103-107 30471562-3 2019 In the present study, we show that deltaTE inhibited TNF-alpha-induced activation of NF-kappaB and LPS-stimulated IL-6 in a dose- and time-dependent manner in Raw 264.7 macrophages. tocotrienol, delta 35-42 interleukin 6 Homo sapiens 114-118 30384152-10 2019 Intriguingly, both resveratrol and JNK inhibitor SP600125 suppressed TNFalpha-induced IL6 and IL8 mRNA expression (P < 0.05). pyrazolanthrone 49-57 interleukin 6 Homo sapiens 86-89 30521963-6 2019 Also, we found that ivabradine inhibited the expression and secretion of interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) as well as the production of reactive oxygen species (ROS). Ivabradine 20-30 interleukin 6 Homo sapiens 73-86 30521963-6 2019 Also, we found that ivabradine inhibited the expression and secretion of interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) as well as the production of reactive oxygen species (ROS). Ivabradine 20-30 interleukin 6 Homo sapiens 88-92 31814545-5 2019 Some flavonoids exert anti-inflammatory effects through: Blockade of NF-kappaB, and NLRP3 inflammasome, inhibition of pro-inflammatory cytokine production, IL-1beta, IL-2, IL-6, TNF-alpha, IL-17A, down regulation of chemokines, and reduction of reactive oxygen and nitrogen species. Flavonoids 5-15 interleukin 6 Homo sapiens 172-176 30369518-15 2018 And we found that 786-O RCC cells secrete high IL-6 levels after low dose stimulation with the TKIs sorafenib, sunitinib and pazopanib, inducing activation of AKT-mTOR pathway, NFkappaB, HIF-2alpha and VEGF expression. Sorafenib 100-109 interleukin 6 Homo sapiens 47-51 30680297-11 2018 Conclusion: Our results indicated that the levels of IL-17, IL-33, and IL-6 in supernatants from patients" cultured T cells were increased after stimulation with HMGB-1 following employing quercetin. Quercetin 189-198 interleukin 6 Homo sapiens 71-75 30076764-0 2018 Chemosensitizing effect of honokiol in oral carcinoma stem cells via regulation of IL-6/Stat3 signaling. honokiol 27-35 interleukin 6 Homo sapiens 83-87 30076764-6 2018 We showed that honokiol reduced the secretion of IL-6 and phosphorylation of STAT3, and the honokiol-inhibited self-renewal, invasion and colony formation were reversed by administration of IL-6. honokiol 15-23 interleukin 6 Homo sapiens 49-53 30076764-6 2018 We showed that honokiol reduced the secretion of IL-6 and phosphorylation of STAT3, and the honokiol-inhibited self-renewal, invasion and colony formation were reversed by administration of IL-6. honokiol 15-23 interleukin 6 Homo sapiens 190-194 30076764-6 2018 We showed that honokiol reduced the secretion of IL-6 and phosphorylation of STAT3, and the honokiol-inhibited self-renewal, invasion and colony formation were reversed by administration of IL-6. honokiol 92-100 interleukin 6 Homo sapiens 190-194 30149196-8 2018 Further mechanism studies demonstrated that chronic minocycline treatment inhibited the microglia activation and decreased the levels of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-alpha). Minocycline 52-63 interleukin 6 Homo sapiens 137-150 30149196-8 2018 Further mechanism studies demonstrated that chronic minocycline treatment inhibited the microglia activation and decreased the levels of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-alpha). Minocycline 52-63 interleukin 6 Homo sapiens 152-156 29532981-7 2018 Serum levels of TNF-alpha, IL-6, and malondialdehyde declined significantly (P < 0.05) in the HAM-RS2-treated group but remained unchanged in the placebo-treated group. high-amylose maize type 2 resistant starch, maize 97-104 interleukin 6 Homo sapiens 27-31 30217257-8 2018 RESULTS: Honokiol significantly decreased pro-inflammatory cytokine (IL1A, IL6) and chemokine (CXCL8, CXCL1, CCL2) mRNA expression and secretion from fetal membranes (amnion and choriodecidua) and myometrium stimulated with LPS, fsl-1 or poly(I:C). honokiol 9-17 interleukin 6 Homo sapiens 75-78 30455994-5 2018 In the present study, we review the clinical results of rituximab, which targets B lymphocytes, siltuximab and tocilizumab, which target the IL-6 pathway, bortezomib, which is a selective proteasome inhibitor, and anakinra, which is an interleukin 1 receptor antagonist. Bortezomib 155-165 interleukin 6 Homo sapiens 141-145 30271438-7 2018 In the D-mannose pretreatment group, induced Treg cell number would decrease if increased IL-6 levels could be detected. Deuterium 7-8 interleukin 6 Homo sapiens 90-94 30185660-6 2018 Additionally, 1,25(OH)2D inhibited M1 macrophage secretion of osteogenic proteins (i.e., Oncostatin M, TNF-alpha, and IL-6). 1,25(oh)2d 14-24 interleukin 6 Homo sapiens 118-122 29911332-2 2018 Although previous study showed the myricitrin possesses antibone loss effects via reducing the expression of IL-6 and partially suppressing reactive oxygen species (ROS) production. myricitrin 35-45 interleukin 6 Homo sapiens 109-113 29951691-0 2018 Synthesis of interleukin 1 beta and interleukin 6 in human lymphocytes is stimulated by tributyltin. tributyltin 88-99 interleukin 6 Homo sapiens 36-49 29951691-3 2018 Secretion of both interleukin 1beta (IL-1beta) and interleukin 6 (IL-6) from human lymphocytes can be increased dependent upon the level of TBT exposure. tributyltin 140-143 interleukin 6 Homo sapiens 51-64 29951691-3 2018 Secretion of both interleukin 1beta (IL-1beta) and interleukin 6 (IL-6) from human lymphocytes can be increased dependent upon the level of TBT exposure. tributyltin 140-143 interleukin 6 Homo sapiens 66-70 29951691-5 2018 Furthermore, the data indicate that these TBT-induced increases in IL-1beta and IL-6 synthesis require MAP kinase signaling pathways. tributyltin 42-45 interleukin 6 Homo sapiens 80-84 29951691-6 2018 Additionally, elevated synthesis of IL-1beta and IL-6 seen at the highest exposures to TBT (200, 200, 50 nM) were accompanied by increases in the mRNA for these cytokines. tributyltin 87-90 interleukin 6 Homo sapiens 49-53 29951691-7 2018 TBT-induced increases in IL-1beta and IL-6 mRNAs were also shown to be dependent on MAP kinase signaling. tributyltin 0-3 interleukin 6 Homo sapiens 38-42 29767263-5 2018 In addition, icariin inhibited the production of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha and induced the production of IL-10. icariin 13-20 interleukin 6 Homo sapiens 49-67 29678772-6 2018 RESULTS: Subjects receiving high dose minocycline not only had greater improvements on the SANS total scores and PANSS negative subscale scores (P < 0.01), but also had greater reductions in IL-1beta and IL-6 serum levels (P < 0.01) when compared with those receiving low dose minocycline or placebo. Minocycline 38-49 interleukin 6 Homo sapiens 207-211 29976873-6 2018 Tianeptine attenuated microglia activation by decreasing the expression of cluster of differentiation 40 (CD40), and major histocompatibility complex class II (MHC II) markers, as well as the release of pro-inflammatory factors: interleukin (IL)-1beta, IL-18, IL-6, tumor necrosis factor alpha (TNF-alpha), and chemokine CC motif ligand 2 (CCL2), and the production of nitric oxide and reactive oxygen species. tianeptine 0-10 interleukin 6 Homo sapiens 260-264 29899223-8 2018 In contrast, patients with high pre-interventional IL-6 and IL-8 serum levels not only poorly responded to TACE but had a significantly impaired overall survival. Chlorotrianisene 107-111 interleukin 6 Homo sapiens 51-55 29888123-12 2018 We found that PRF in combination with NBT increased beta-EP levels and decreased plasma IL-6 and SP, thereby alleviating pain and hyperalgesia in PHN patients. Nitroblue Tetrazolium 38-41 interleukin 6 Homo sapiens 88-99 29660509-8 2018 In particular, TA-SA-Glu exhibited a comparable anti-inflammatory efficacy to TA in terms of inhibiting the production of nitric oxide, tumor necrosis factor-alpha, and interleukin-6 in activated RAW264.7 macrophages. Triamcinolone Acetonide 15-17 interleukin 6 Homo sapiens 169-182 29524384-0 2018 Diesel exhaust particles (DEP) induce an early redox imbalance followed by an IL-6 mediated inflammatory response on human conjunctival epithelial cells. exhaust 7-14 interleukin 6 Homo sapiens 78-82 29404796-9 2018 Plasma IL-6 and IL-8 levels after surgery were significantly lower in the PMMA group than in the PS group, while other cytokines measured in this study were not significantly different. Polymethyl Methacrylate 74-78 interleukin 6 Homo sapiens 7-11 29404796-11 2018 The continuous use of PMMA-CRRT throughout the perioperative period suppressed serum IL-6 and IL-8 concentrations, although there were no differences in clinical outcomes. Polymethyl Methacrylate 22-26 interleukin 6 Homo sapiens 85-89 29787569-10 2018 IL-6 production in bDMARD-treated explants was significantly higher among clinical non-responders compared to responders (P = 0.04), and a lack of suppression of IL-6 by the bDMARDS correlated to a high DAS-28 (rho = 0.57, P = 0.03), CDUS (rho = 0.53, P = 0.04) and bone marrow oedema (rho = 0.56, P = 0.03) at follow-up. bdmard 19-25 interleukin 6 Homo sapiens 0-4 29555477-7 2018 We found that AZT decreased nuclear factor kappa B (NF-kappaB) and Interleukin-6 (IL-6) levels, increased Superoxide Dismutase 1 (SOD1) production, decreased ROS production, and increased cell viability. Zidovudine 14-17 interleukin 6 Homo sapiens 67-80 29555477-7 2018 We found that AZT decreased nuclear factor kappa B (NF-kappaB) and Interleukin-6 (IL-6) levels, increased Superoxide Dismutase 1 (SOD1) production, decreased ROS production, and increased cell viability. Zidovudine 14-17 interleukin 6 Homo sapiens 82-86 29431121-9 2018 Mechanistically, MTX-induced macrophage tolerance was dependent on A20, as siRNA-mediated knockdown of A20 reversed the MTX-induced reduction of IL-6 expression. Methotrexate 17-20 interleukin 6 Homo sapiens 145-149 29431121-9 2018 Mechanistically, MTX-induced macrophage tolerance was dependent on A20, as siRNA-mediated knockdown of A20 reversed the MTX-induced reduction of IL-6 expression. Methotrexate 120-123 interleukin 6 Homo sapiens 145-149 29668463-13 2018 TMAO correlated with IL-6, endotoxin and chemerin. trimethyloxamine 0-4 interleukin 6 Homo sapiens 21-25 29651140-0 2018 Novel Indole-fused benzo-oxazepines (IFBOs) inhibit invasion of hepatocellular carcinoma by targeting IL-6 mediated JAK2/STAT3 oncogenic signals. ifbos 37-42 interleukin 6 Homo sapiens 102-106 29707128-3 2018 MCF-7 cells co-expressing RANTES and IL-6 had a greater ability to form colonies in soft agar, compared to cells overexpressing RANTES or IL-6. Agar 89-93 interleukin 6 Homo sapiens 37-41 29360942-0 2018 IL-6 trans-signalling contributes to aldosterone-induced cardiac fibrosis. Aldosterone 37-48 interleukin 6 Homo sapiens 0-4 29360942-2 2018 Interleukin-6 (IL-6) is a key mediator in the fibrotic process; however, the effect of aldosterone on the expression of IL-6 remains unclear. Aldosterone 87-98 interleukin 6 Homo sapiens 120-124 29360942-3 2018 We investigated whether aldosterone induces the expression of IL-6 and thereby contributes to the fibrotic process. Aldosterone 24-35 interleukin 6 Homo sapiens 62-66 29360942-6 2018 In addition, plasma IL-6 levels were positively correlated with 24-h urinary aldosterone and echocardiographic parameters. Aldosterone 77-88 interleukin 6 Homo sapiens 20-24 29360942-7 2018 In cell studies, we investigated the possible molecular mechanism how aldosterone-induced IL-6 secretion and the further effects of collagen production. Aldosterone 70-81 interleukin 6 Homo sapiens 90-94 29360942-10 2018 In cardiac fibroblasts, IL-6 trans-signalling played a critical role in aldosterone-induced IL-6-enhanced fibrosis-related factor expression. Aldosterone 72-83 interleukin 6 Homo sapiens 24-28 29360942-10 2018 In cardiac fibroblasts, IL-6 trans-signalling played a critical role in aldosterone-induced IL-6-enhanced fibrosis-related factor expression. Aldosterone 72-83 interleukin 6 Homo sapiens 92-96 29360942-13 2018 Conclusions: IL-6 trans-signalling contributes to aldosterone-induced cardiac fibrosis. Aldosterone 50-61 interleukin 6 Homo sapiens 13-17 29506853-7 2018 miR-133a and miR-208a were significantly related to IL-6 (r = 0.287, P = 0.036; r = 0.292, P = 0.032, respectively). mir-133a 0-8 interleukin 6 Homo sapiens 52-56 29484442-7 2018 In the present study, lysophosphatidylcholine (LPC) significantly increased the secretion of IL-6 and TNF-alpha in VECs. Lysophosphatidylcholines 22-45 interleukin 6 Homo sapiens 93-97 29484442-7 2018 In the present study, lysophosphatidylcholine (LPC) significantly increased the secretion of IL-6 and TNF-alpha in VECs. Lysophosphatidylcholines 47-50 interleukin 6 Homo sapiens 93-97 28919446-5 2018 In turn, in vivo Modafinil treatment enhanced splenocyte production of IFN-gamma, IL-6 and tumor necrosis factor (TNF), and increased the number of IFN-gamma producing cells. Modafinil 17-26 interleukin 6 Homo sapiens 82-86 28840599-6 2018 IL-6 secretion was examined after 24 hour, 48 hour or 6 day exposures to TBT and DBT in highly enriched human natural killer cells, monocyte-depleted peripheral blood mononuclear cells (PBMCs), PBMCs, granulocytes and a preparation combining both PBMCs and granulocytes (PBMCs + granulocytes). tributyltin 73-76 interleukin 6 Homo sapiens 0-4 28840599-8 2018 Significant decreases of IL-6 secretion were seen at the highest concentration of TBT (200 nm) and DBT (5-2.5 mum) while the lower concentrations of DBT (0.05 and 0.1 mum) caused elevation of IL-6 secretion. tributyltin 82-85 interleukin 6 Homo sapiens 25-29 30001663-4 2018 Mechanistically, IL-6 induces the release of free fatty acid (FFA) and leptin from adipocytes thereby affecting liver metabolism and pancreatic beta-cell function, respectively. Fatty Acids, Nonesterified 45-60 interleukin 6 Homo sapiens 17-21 29794481-7 2018 Moreover, the midazolam group exhibited lower oxidative stress markers with a higher fold change in IL-6 and TNF-alpha mRNA levels. Midazolam 14-23 interleukin 6 Homo sapiens 100-104 29059354-9 2018 Aldosterone significantly induced IL-6 and fibrosis gene mRNA expression in differentiated SVF cells. Aldosterone 0-11 interleukin 6 Homo sapiens 34-38 29250144-5 2017 It was determined that difference concentrations of formononetin (0.1, 1 and 10 microM) suppressed histamine release and secretion of TNF-alpha, IL-1beta and IL-6. formononetin 52-64 interleukin 6 Homo sapiens 158-162 29155869-5 2017 We found that PPS enhanced the activities of IFN-gamma-stimulated RAW 264.7 macrophages, as shown by the release of inducible nitric oxide synthase (INOS), secretion of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, phagocytosis activity, as well as expression of M1 phenotype indicators, such as CD40, CD284 and CD86. pps 14-17 interleukin 6 Homo sapiens 207-225 28752178-7 2017 Tofacitinib significantly down-regulated CTS-induced expression of ADAMTS4, ADAMTS5, MMP13, and RUNX2, and the release of IL-6 in supernatant by chondrocytes. castanospermine 41-44 interleukin 6 Homo sapiens 122-126 28766731-13 2017 Levels of CXCL-8 (C-X-C motif chemokine ligand 1) and interleukin-6 were significantly higher after treatment with RMPs. rmps 115-119 interleukin 6 Homo sapiens 54-67 28808571-7 2017 TNF-alpha and IL-6 levels were significantly decreased (P<0.05) by the effect of mCRP and pCRP combined with oxLDL. mcrp 84-88 interleukin 6 Homo sapiens 14-18 28051087-3 2017 Compared with samples from unexposed women in the mid-luteal phase, depot-medroxyprogesterone acetate use was associated with: increased endocervical concentrations of MCP1 and IFNalpha2; decreased endocervical concentrations of IL1beta and IL6; increased proportions of endometrial CD4+ and CD8+ cells expressing the activation marker HLADR; increased density of endometrial macrophages; and decreased density of endometrial regulatory T cells. Medroxyprogesterone Acetate 74-101 interleukin 6 Homo sapiens 241-244 28794655-7 2017 ADPbetas-evoked increase in Iba-1, IL-1beta, IL-6 and TNF-alpha mRNA expression was inhibited only partially by P2Y12 receptor antagonist MRS2395 or P2Y13 receptor antagonist MRS2211, respectively. adenosine 5'-O-(2-thiodiphosphate) 0-8 interleukin 6 Homo sapiens 45-49 28903416-7 2017 786-O RCC cells secrete high IL-6 levels after low dose stimulation with the TKIs sorafenib, sunitinib and pazopanib, inducing activation of AKT-mTOR pathway, NFkappaB, HIF-2alpha and VEGF expression. Sorafenib 82-91 interleukin 6 Homo sapiens 29-33 28693194-9 2017 Therefore, the combination of warfarin and lenalidomide may cause a pharmacodynamic interaction, more likely by inhibiting the production of interleukin-6. Warfarin 30-38 interleukin 6 Homo sapiens 141-154 28839362-7 2017 The methanol extracts of seeds also demonstrated the highest inhibition of TNF-alpha, IL-1beta, IL-6, and IFN-gamma production. Methanol 4-12 interleukin 6 Homo sapiens 96-100 28467797-6 2017 KY-05009 and dovitinib synergistically inhibited interleukin-6-stimulated proliferation and induced apoptosis through the inhibition of Wnt signaling in MM cells. 5-(4-methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide 0-8 interleukin 6 Homo sapiens 49-62 28467797-6 2017 KY-05009 and dovitinib synergistically inhibited interleukin-6-stimulated proliferation and induced apoptosis through the inhibition of Wnt signaling in MM cells. 4-amino-5-fluoro-3-(5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl)quinolin-2(1H)-one 13-22 interleukin 6 Homo sapiens 49-62 28606092-6 2017 In addition, we found an increase in the cytokine secretion of IL-6 and chemokine IL-8 in FFA-treated HC in comparison to the untreated HC. Fatty Acids, Nonesterified 90-93 interleukin 6 Homo sapiens 63-67 28402673-12 2017 In conclusion, ACL enhances the therapeutic and anticancer efficacy of MTX, when coencapsulated into fucose-anchored LPHNPs, as confirmed by cell viability and serum angiogenesis (IL-6, TNF-alpha, IL-1beta, COX2, and MMP1) at both transcript and proteome level. Methotrexate 71-74 interleukin 6 Homo sapiens 180-184 28343970-0 2017 Phenylmethimazole and a thiazole derivative of phenylmethimazole inhibit IL-6 expression by triple negative breast cancer cells. Thiazoles 24-32 interleukin 6 Homo sapiens 73-77 28735516-10 2017 The results of BSP revealed significant DNA hypermethylation at the promoter region of Cdh1 after IL-6 and TGF-beta1 exposure, which was rescued when pretreated with 5-Aza or TGF-beta1 antibody. Azacitidine 166-171 interleukin 6 Homo sapiens 98-102 28240768-6 2017 In the LPS model of pulmonary inflammation, eucalyptol treatment diminished leukocyte infiltration, myeloperoxidase activity and production of TNF-alpha, IL-1beta, IFN-gamma and IL-6. Eucalyptol 44-54 interleukin 6 Homo sapiens 178-182 28259909-7 2017 CACNAD2A3, GDF5 and IL6 were upregulated and NANOG was downregulated in the MCF7 breast cancer cells expressing increased levels of PAR4 after treatment with docetaxel, likely indicating inactivation of the WNT/beta-catenin pathway. Docetaxel 158-167 interleukin 6 Homo sapiens 20-23 28000839-9 2017 IL-6 and IL-8 expression was inhibited completely by treatment with the NF-kappaB inhibitor, BAY11-7082. 3-(4-methylphenylsulfonyl)-2-propenenitrile 93-103 interleukin 6 Homo sapiens 0-4 28149280-0 2016 The MEK-Inhibitor Selumetinib Attenuates Tumor Growth and Reduces IL-6 Expression but Does Not Protect against Muscle Wasting in Lewis Lung Cancer Cachexia. AZD 6244 18-29 interleukin 6 Homo sapiens 66-70 28149280-6 2016 Moreover, Selumetinib has also been shown to inhibit the production of IL-6. AZD 6244 10-21 interleukin 6 Homo sapiens 71-75 28149280-12 2016 Treatment with Selumetinib reduced tumor mass and reduced circulating and tumor IL-6; however MEK inhibition did not preserve muscle mass. AZD 6244 15-26 interleukin 6 Homo sapiens 80-84 33659044-5 2021 RESULTS: HSCs cultured with Ca.-CM, TAM-CM and CAF-CM showed significantly increased mRNA expression of alphaSMA, FAP and IL-6. tam 36-39 interleukin 6 Homo sapiens 122-126 32918399-7 2021 Sorafenib also inhibited steatosis-induced fibrogenesis by downregulating COL1A1, TGFB1, PDGF, and TIMP1 and by decreasing protein levels of IL-6, TGF-beta1, and TNF-alpha in fatty spheroids. Sorafenib 0-9 interleukin 6 Homo sapiens 141-145 32955957-6 2021 After 12 months, rosuvastatin produced a significant decrease in mean serum levels of hsCRP (-0.28 mg/dL; p = .037), IL-6 (-2.1 pg/mL; p = .018) and TNF-alpha (-6.3 pg/mL; p = .004) in patients with MetS. Rosuvastatin Calcium 17-29 interleukin 6 Homo sapiens 117-121 32749708-0 2021 Can aldosterone increase interleukin-6 levels in Covid-19 pneumonia? Aldosterone 4-15 interleukin 6 Homo sapiens 25-38 33278444-9 2021 Moreover, quercetin-glycyrrhizin nanogels were more effective in down-regulating the inflammation-related gene expression of tumor necrosis factor-alpha, interleukin-6, inducible nitric oxide synthase and monocyte chemotactic protein-1. Quercetin 10-19 interleukin 6 Homo sapiens 154-167 33575345-4 2021 Sudachitin inhibited IL-1beta-induced IL-6, IL-8, CXC chemokine ligand (CXCL)10, CC chemokine ligand (CCL)2, MMP-1, and MMP-3 production in HPDLC. sudachitin 0-10 interleukin 6 Homo sapiens 38-42 33536774-0 2021 Relationship Between Interleukin-6 -174G/C Genetic Variant and Efficacy of Methotrexate Treatment in Psoriatic Arthritis Patients. Methotrexate 75-87 interleukin 6 Homo sapiens 21-34 33536774-1 2021 Introduction: The purpose of the study was to investigate whether single-nucleotide polymorphisms (SNPs) IL-6 -174 G/C and IL-6R Asp358Ala are associated with susceptibility to psoriatic arthritis (PsA) or affect response to treatment with methotrexate (MTX). Methotrexate 240-252 interleukin 6 Homo sapiens 105-109 33536774-1 2021 Introduction: The purpose of the study was to investigate whether single-nucleotide polymorphisms (SNPs) IL-6 -174 G/C and IL-6R Asp358Ala are associated with susceptibility to psoriatic arthritis (PsA) or affect response to treatment with methotrexate (MTX). Methotrexate 254-257 interleukin 6 Homo sapiens 105-109 33536774-5 2021 Results: A significant association between the IL-6 -174 CC genotype and an improved clinical outcome of MTX therapy was observed. Methotrexate 105-108 interleukin 6 Homo sapiens 47-51 33536774-7 2021 On the other hand, patients carrying the IL-6 -174 GC genotype less frequently responded to MTX treatment as compared to patients with other genotypes (P = 0.006). Methotrexate 92-95 interleukin 6 Homo sapiens 41-45 33536774-10 2021 Conclusion: Results from this study provide evidence that the IL-6 -174 G/C polymorphism might influence efficacy of MTX treatment. Methotrexate 117-120 interleukin 6 Homo sapiens 62-66 33501560-1 2021 OBJECTIVE: Our study aims to determine the influence of smoking or tobacco chewing and the association of Interleukin 6 (IL-6) polymorphism, where G is substituted by A at the position - 596 (IL-6 - 596 G/A) and substitution of G by cytosine (C) at position - 572 (IL-6 - 572 G/C) on the susceptibility of precancerous oral lesions and oral cancer. Cytosine 233-241 interleukin 6 Homo sapiens 121-125 33501560-1 2021 OBJECTIVE: Our study aims to determine the influence of smoking or tobacco chewing and the association of Interleukin 6 (IL-6) polymorphism, where G is substituted by A at the position - 596 (IL-6 - 596 G/A) and substitution of G by cytosine (C) at position - 572 (IL-6 - 572 G/C) on the susceptibility of precancerous oral lesions and oral cancer. Cytosine 233-241 interleukin 6 Homo sapiens 192-196 33501560-1 2021 OBJECTIVE: Our study aims to determine the influence of smoking or tobacco chewing and the association of Interleukin 6 (IL-6) polymorphism, where G is substituted by A at the position - 596 (IL-6 - 596 G/A) and substitution of G by cytosine (C) at position - 572 (IL-6 - 572 G/C) on the susceptibility of precancerous oral lesions and oral cancer. Cytosine 233-241 interleukin 6 Homo sapiens 192-196 33501560-1 2021 OBJECTIVE: Our study aims to determine the influence of smoking or tobacco chewing and the association of Interleukin 6 (IL-6) polymorphism, where G is substituted by A at the position - 596 (IL-6 - 596 G/A) and substitution of G by cytosine (C) at position - 572 (IL-6 - 572 G/C) on the susceptibility of precancerous oral lesions and oral cancer. Cytosine 4-5 interleukin 6 Homo sapiens 121-125 33501560-1 2021 OBJECTIVE: Our study aims to determine the influence of smoking or tobacco chewing and the association of Interleukin 6 (IL-6) polymorphism, where G is substituted by A at the position - 596 (IL-6 - 596 G/A) and substitution of G by cytosine (C) at position - 572 (IL-6 - 572 G/C) on the susceptibility of precancerous oral lesions and oral cancer. Cytosine 4-5 interleukin 6 Homo sapiens 192-196 33501560-1 2021 OBJECTIVE: Our study aims to determine the influence of smoking or tobacco chewing and the association of Interleukin 6 (IL-6) polymorphism, where G is substituted by A at the position - 596 (IL-6 - 596 G/A) and substitution of G by cytosine (C) at position - 572 (IL-6 - 572 G/C) on the susceptibility of precancerous oral lesions and oral cancer. Cytosine 4-5 interleukin 6 Homo sapiens 192-196 32390406-13 2021 Furthermore, astragalin reduced the level of phosphorylated IkappaBalpha and decreased the production of the inflammatory cytokines IL-6, IL-8, and TNF-alpha in the DSS-treated colon mucosa. Dextran Sulfate 165-168 interleukin 6 Homo sapiens 132-136 33167270-0 2021 A novel electrochemical immunosensor based on acetylene black/epoxy-substituted-polypyrrole polymer composite for the highly sensitive and selective detection of interleukin 6. epoxy-substituted-polypyrrole polymer 62-99 interleukin 6 Homo sapiens 162-175 33167270-1 2021 An ultrasensitive immunosensor based on acetylene black (AB)/epoxy-substituted-poly(pyrrole) polymer (EpxS-PPyr) composite coated disposable indium tin oxide (ITO) electrode was fabricated for interleukin 6 (IL 6) detection. epxs-ppyr 102-111 interleukin 6 Homo sapiens 193-206 33167270-1 2021 An ultrasensitive immunosensor based on acetylene black (AB)/epoxy-substituted-poly(pyrrole) polymer (EpxS-PPyr) composite coated disposable indium tin oxide (ITO) electrode was fabricated for interleukin 6 (IL 6) detection. epxs-ppyr 102-111 interleukin 6 Homo sapiens 208-212 33435880-11 2021 Co-culture with HBV-T cells could reduce IFN-gamma and TNF-alpha, production while increase IL-6 and IL-10 production in HepG2.2.15 cells; these alterations could be partially reversed by amygdalin pretreatment. Amygdalin 188-197 interleukin 6 Homo sapiens 92-96 33505496-5 2021 TACE induced significant increases of neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), IL-1beta, IL-2R, IL-6, and IL-8. Chlorotrianisene 0-4 interleukin 6 Homo sapiens 123-127 33570632-0 2021 Modulation of IL-6/STAT3 signaling axis in CD4+FOXP3- T cells represents a potential antitumor mechanism of azacitidine. Azacitidine 108-119 interleukin 6 Homo sapiens 14-18 33570632-5 2021 We further observed an AZA-mediated downregulation of intereukin-6 (IL-6)-induced STAT3 phosphorylation in CD4+FOXP3- conventional T cells (Tcons) that correlated independently with better response and survival, whereas it was also not associated with the mutation number and profile of the patients. Azacitidine 23-26 interleukin 6 Homo sapiens 68-72 33570632-6 2021 The AZA-induced downregulation of IL-6/STAT3 axis in Tcons restored the STAT signaling architecture in CD4+ T-cell subsets, whereas STAT signaling networks remained disorganized in patients who upregulated IL-6/STAT3 activity in Tcons. Azacitidine 4-7 interleukin 6 Homo sapiens 34-38 33570632-6 2021 The AZA-induced downregulation of IL-6/STAT3 axis in Tcons restored the STAT signaling architecture in CD4+ T-cell subsets, whereas STAT signaling networks remained disorganized in patients who upregulated IL-6/STAT3 activity in Tcons. Azacitidine 4-7 interleukin 6 Homo sapiens 206-210 33570632-7 2021 Given the pivotal role of CD4+ T cells in adaptive immunity, our findings suggest that the downregulation of the IL-6/STAT3 pathway in Tcons potentially constitutes a previously unrecognized immune-mediated mechanism of action of AZA and sets the scene for developing rational strategies of AZA combinations with IL-6/STAT3 axis inhibitors. Azacitidine 230-233 interleukin 6 Homo sapiens 113-117 33570632-7 2021 Given the pivotal role of CD4+ T cells in adaptive immunity, our findings suggest that the downregulation of the IL-6/STAT3 pathway in Tcons potentially constitutes a previously unrecognized immune-mediated mechanism of action of AZA and sets the scene for developing rational strategies of AZA combinations with IL-6/STAT3 axis inhibitors. Azacitidine 230-233 interleukin 6 Homo sapiens 313-317 33570632-7 2021 Given the pivotal role of CD4+ T cells in adaptive immunity, our findings suggest that the downregulation of the IL-6/STAT3 pathway in Tcons potentially constitutes a previously unrecognized immune-mediated mechanism of action of AZA and sets the scene for developing rational strategies of AZA combinations with IL-6/STAT3 axis inhibitors. Azacitidine 291-294 interleukin 6 Homo sapiens 113-117 33055419-7 2021 We identified fluvastatin as an inducer of galectin-7 expression by connectivity map (cMAP) analysis, confirmed this effect in keratinocytes, and demonstrated that fluvastatin attenuated IL-6 and IL-8 production induced by IL-17A. Fluvastatin 14-25 interleukin 6 Homo sapiens 187-191 33055419-7 2021 We identified fluvastatin as an inducer of galectin-7 expression by connectivity map (cMAP) analysis, confirmed this effect in keratinocytes, and demonstrated that fluvastatin attenuated IL-6 and IL-8 production induced by IL-17A. Fluvastatin 164-175 interleukin 6 Homo sapiens 187-191 33142636-5 2021 Three NPs greatly promoted the expression and secretion of interleukin-6 (IL-6), tumor necrosis factor (TNF-alpha), and interleukin-1beta (IL-1beta) in DC cells: C2,3,6 chitosan sulfate-HACC (C2,3,6-HACC; 200 kDa), C3,6 chitosan sulfate-HACC (C3,6-HACC; 200 kDa) and C6 chitosan sulfate-HACC (C6-HACC; 50 kDa). c2,3,6 chitosan sulfate 162-185 interleukin 6 Homo sapiens 59-72 33142636-5 2021 Three NPs greatly promoted the expression and secretion of interleukin-6 (IL-6), tumor necrosis factor (TNF-alpha), and interleukin-1beta (IL-1beta) in DC cells: C2,3,6 chitosan sulfate-HACC (C2,3,6-HACC; 200 kDa), C3,6 chitosan sulfate-HACC (C3,6-HACC; 200 kDa) and C6 chitosan sulfate-HACC (C6-HACC; 50 kDa). c2,3,6 chitosan sulfate 162-185 interleukin 6 Homo sapiens 74-78 33540416-12 2021 RESULTS: 1,25 Dihydroxycholecalciferol (1,25 (OH)2 D3) significantly reduced TNF-alpha production in LPS-activated ESCs and TNF-alpha and IL-6 production by LTA-stimulated WECs. lipoteichoic acid 157-160 interleukin 6 Homo sapiens 138-142 33380406-5 2020 RESULTS: In the cell co-culture system, SBi4211 treatment significantly inhibited gp120-induced expression of S100B, RAGE and GFAP in U251 cells (P < 0.001), reduced the levels of inflammatory factors iNOS, IL-6 and TNF-alpha (P < 0.001) and enhanced the expressions of neuron-related proteins NeuN, Syn and MAP-2 (P < 0.001). Heptamidine 40-47 interleukin 6 Homo sapiens 207-211 33336491-6 2021 Notably, CD4+ T cells from patients in HAT and from persons using illicit heroin showed significant reduced proliferation and secretion of the pro-inflammatory cytokines IFN-gamma and IL-6 upon stimulation in vitro. Heroin 74-80 interleukin 6 Homo sapiens 184-188 33183549-6 2020 CONCLUSIONS: Overall, this meta-analysis demonstrated flaxseed oil supplementation decreased IL-6 and MDA levels, and increased TAC, but did not affect other biomarkers of inflammation and oxidative stress among patients with MetS and related disorders. Linseed Oil 54-66 interleukin 6 Homo sapiens 93-97 32912735-9 2020 CONCLUSION: Cytosorb courses achieved significant decreases in endocan, copeptin, interleukin-6, procalcitonin and C-reactive protein levels. cytosorb 12-20 interleukin 6 Homo sapiens 82-95 33256638-9 2020 IL-6 and IL-10 levels were significantly higher in non-survivors than in survivors on days 2-5 post-bacteremia (P = 0.010 and P = 0.021, respectively), and those dying within 7 d of SAB (n = 3) displayed significantly higher IL-10/TNF-alpha ratios than the survivors did (P = 0.007). sab 182-185 interleukin 6 Homo sapiens 0-4 33273830-0 2020 Erratum: IL-6/STAT3 Signaling Contributes to Sorafenib Resistance in Hepatocellular Carcinoma Through Targeting Cancer Stem Cells [Corrigendum]. Sorafenib 45-54 interleukin 6 Homo sapiens 9-13 32910941-8 2020 Collectively, our findings demonstrate that IL-6-induced acetylation of E2F1 impairs the antioxidant capacity of RPE cells by disturbing the pentose phosphate pathway, which elucidates a relationship between the intraocular microenvironment and RPE oxidative damage in AMD and provides a possible therapeutic target for AMD. Pentosephosphates 141-158 interleukin 6 Homo sapiens 44-48 33010093-10 2020 PWH had higher levels of the inflammatory markers CRP and IL-6. PWH 0-3 interleukin 6 Homo sapiens 58-62 32830258-8 2020 CDEC exposed to MCM from IgA1-stimulated THP-1 cells (THP-1-IgA-MCM) exhibited markedly increased expression of neutrophil-associated gelatinase (NGAL) and proinflammatory cytokinesinterleukin (IL)-1beta, tumour necrosis factor-alpha, IL-6 and IL-8 compared with MCM from non-IgA-stimulated THP-1 cells (THP-1-MCM). CDEC 0-4 interleukin 6 Homo sapiens 235-239 32830258-10 2020 THP-1-IgA-MCM-derived exosomes induced similar increases in NGAL and cytokine expression while in cross-over experiments exosomes extracted from IL-1beta-exposed CDEC induced IL-1beta and IL-6 mRNA expression in both sets of macrophages. CDEC 162-166 interleukin 6 Homo sapiens 188-192 32652021-8 2020 Patients in high PPS group, with significantly abnormal coagulation, have a higher levels of interleukin 6 (25.27 pg/ml vs.2.55 pg/ml, P < 0.001), prophylactic anticoagulation rate (60.7% vs. 6.5%, P<0.001) and mortality (40.5% vs. 5.9%, P<0.001) as compared with that in low PPS group. pps 17-20 interleukin 6 Homo sapiens 93-106 32599111-9 2020 Furthermore, TMAO levels was associated with disease severity in AAD, and correlated positively with CRP levels (r=0.537, P=0.018), IL-6 levels (r=0.546, P=0.016), D-dimer levels (r=0.694, P=0.001) and maximum aortic diameter on admission (r=0.748, P=0.002). trimethyloxamine 13-17 interleukin 6 Homo sapiens 132-136 32991579-4 2020 Interaction of the above-mentioned alkaloids with acetylcholinesterase enzyme and interleukins IL-6 and IL-8 was investigated in silico by molecular docking. Alkaloids 35-44 interleukin 6 Homo sapiens 95-99 32856796-8 2020 And the protein and mRNA expressions of TNF-alpha and IL-6 were increased by Phe, Flu, and their mixture, respectively. fluorene 82-85 interleukin 6 Homo sapiens 54-58 32824426-9 2020 Co-inhibition of ERK and JNK signaling pathways by their specific inhibitors (PD9805 and SP600125, respectively) resulted in the suppression of mRNA and protein levels of IL-6, IL-1beta, and TNFalpha in FLS. pyrazolanthrone 89-97 interleukin 6 Homo sapiens 171-175 32953809-10 2020 When studied in vitro, TMAO treatment significantly promoted BMSCs adipogenesis and attenuated osteogenesis, increased ROS release and pro-inflammatory cytokine IL-1beta, IL-6 and TNF-alpha production, and inhibited cell proliferation. trimethyloxamine 23-27 interleukin 6 Homo sapiens 171-175 32765941-5 2020 Since PGE2, LXA4 and their precursors AA (arachidonic acid), dihomo-gamma-linolenic acid (DGLA) and gamma-linolenic acid (GLA) inhibit the production of pro-inflammatory IL-6 and TNF-alpha, they could be employed to treat cytokine storm seen in COVID-19, immune check point inhibitory (ICI) therapy, sepsis and ARDS (acute respiratory disease). lipoxin A4 12-16 interleukin 6 Homo sapiens 170-174 32698404-8 2020 Stimulation with Alcaligenes lipid A also induced the production of IL-6 and IL-1beta in human peripheral blood mononuclear cells. Lipid A 29-36 interleukin 6 Homo sapiens 68-72 32834826-12 2020 IDO may upregulate Treg numbers by stimulating IL-10 production and inhibiting IL-6 expression. treg 19-23 interleukin 6 Homo sapiens 79-83 32295807-8 2020 Specifically, 19% and 12% of type 2 diabetes risk due to manganese were mediated through interleukin 6 and hs-CRP, respectively. Manganese 57-66 interleukin 6 Homo sapiens 89-102 32483313-6 2020 IL-6 targeting tumor suppressor miR-149-5p was found to be the novel miRNA that was up-regulated by propofol, resulting in the observed effects on cell viability, IL-6 production, mammospheres generation as well as EMT induction. mir-149-5p 32-42 interleukin 6 Homo sapiens 0-4 32032599-10 2020 Furthermore, both our in vivo and in vitro results reveal that WFA treatment could significantly reduce levels of several neuroinflammation cytokines (IL-1beta, IL-6, and TNF-alpha), which correlate with an overall reduction in microglial activation. withaferin A 63-66 interleukin 6 Homo sapiens 161-165 32200535-4 2020 By inhibition of NF-kappaB, 1,8-cineole, at relevant plasma concentrations (1.5 microg/ml), strongly and significantly inhibited in normal human monocyte lipopolysaccharide (LPS)-stimulated cytokines relevant for exacerbation (tumour necrosis factor alpha (TNFalpha), interleukin (IL)-1beta and systemic inflammation (IL-6, IL-8). Eucalyptol 28-39 interleukin 6 Homo sapiens 318-322 32186758-7 2020 The M1-related phenotypic indicators, iNOS, TNF-alpha, IL-1beta, IL-6 and CD86, were inhibited by the NF-kappaB (p65) signalling pathway inhibitor BAY117082. 3-(4-methylphenylsulfonyl)-2-propenenitrile 147-156 interleukin 6 Homo sapiens 65-69 31909645-8 2020 Real-time PCR analysis of the aorta showed that IL-6 and MCP-1 expression was up-regulated upon treatment with In2O3 NPs. Indium oxide (In2O3) 111-116 interleukin 6 Homo sapiens 48-52 32233673-4 2021 Treatment of the LPS-stimulated PBMCs with the isolated flavonoids at a concentration of 100 microM significantly reduced the production of interleukins (IL-1beta, IL-2 and IL-6), interferon-gamma (IFN-gamma), granulocyte macrophage-colony stimulating factor (GM-CSF) and tumour necrosis factor-alpha (TNF-alpha). Flavonoids 56-66 interleukin 6 Homo sapiens 173-177 32280713-0 2020 Expression of H2S in Gestational Diabetes Mellitus and Correlation Analysis with Inflammatory Markers IL-6 and TNF-alpha. Deuterium 14-17 interleukin 6 Homo sapiens 102-106 32280713-5 2020 With regression, IL-6 and TNF-alpha concentrations were positively correlated with the level of blood glucose and negatively correlated with H2S concentration. Deuterium 141-144 interleukin 6 Homo sapiens 17-21 31785407-4 2020 The results showed that aldosterone induced the expression of IL-6 via mineralocorticoid receptors, and enhanced THP-1 cell migration and infiltration. Aldosterone 24-35 interleukin 6 Homo sapiens 62-66 31059805-7 2020 Treatment of human U251 and TG1 glioblastoma cells with both flavonoids also modulated negatively the expression of mRNA for IL-6 and IL-10 and positively the expression of mRNA for TNF characterizing changes to the immune regulatory profile. Flavonoids 61-71 interleukin 6 Homo sapiens 125-129 31555812-2 2020 STAT3 becomes phosphorylated at Tyr705 and Ser727 on IL-6 stimulation. seryl-seryl-seryl-arginine 43-46 interleukin 6 Homo sapiens 53-57 31555812-7 2020 Impaired reactivation of STAT3 by S727A or FLAG-tag delayed or inhibited the IL-6-induced saa1 mRNA expression, respectively. FLAG peptide 43-47 interleukin 6 Homo sapiens 77-81 32095449-11 2020 However, serum IL-6 levels significantly decreased in the flaxseed oil group compared to the sunflower oil group (p = 0.017). Linseed Oil 58-70 interleukin 6 Homo sapiens 15-19 32095449-13 2020 We observed that consumption of flaxseed oil improved serum IL-6 levels but had no effect on oxidative stress and coagulation score in patients with MetS. Linseed Oil 32-44 interleukin 6 Homo sapiens 60-64 31971958-8 2020 RESULTS: Dolutegravir reduced inflammation by decreasing NFkappaB activation and IL-6/IL-8/sICAM-1/sVCAM-1 secretion, as did maraviroc with a milder effect. dolutegravir 9-21 interleukin 6 Homo sapiens 81-85 32581181-7 2020 In pretreated gingival fibroblasts and HSC-2 cells, TCA considerably reduced the expression of IL1beta, IL6, and IL8. Taurocholic Acid 52-55 interleukin 6 Homo sapiens 104-107 32581181-9 2020 An immunoassay confirmed the capacity of TCA to diminish inflammation-induced expression of IL6 in gingival fibroblasts, HSC-2 and RAW 264.7 cells. Taurocholic Acid 41-44 interleukin 6 Homo sapiens 92-95 31392929-5 2019 Here, adenine was found to significantly inhibit the secretion of lipopolysaccharide-induced inflammatory cytokines such as TNF-alpha, IL-1beta and IL-6 in THP-1 cells. Adenine 6-13 interleukin 6 Homo sapiens 148-152 31866771-5 2019 Results: (1) The levels of hs-CRP, IL-6, and IL-8 were significantly increased in the UAP and AMI groups compared with the CPS group (P < 0.01). 4-Deoxy-2-O-Sulfo-Alpha-L-Threo-Hex-4-Enopyranuronic Acid 86-89 interleukin 6 Homo sapiens 35-39 31759770-8 2019 IL-6 and TNF-alpha production was depressed only in those on Smoflipid. smoflipid 61-70 interleukin 6 Homo sapiens 0-4 31249138-1 2019 BACKGROUND: The aim of this study was to determine the potential prognostic roles of the perioperative interleukin-6 (IL-6) level and its dynamic changes in patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE). Chlorotrianisene 246-250 interleukin 6 Homo sapiens 118-122 30361813-12 2019 Paeoniflorin suppressed IL-6 production and secretion by up-regulating microRNA149 expression in GCAFs, and subsequently prevented GCAFs from activating IL-6-STAT3-MMP signaling of AGS cells. peoniflorin 0-12 interleukin 6 Homo sapiens 24-28 30361813-12 2019 Paeoniflorin suppressed IL-6 production and secretion by up-regulating microRNA149 expression in GCAFs, and subsequently prevented GCAFs from activating IL-6-STAT3-MMP signaling of AGS cells. peoniflorin 0-12 interleukin 6 Homo sapiens 153-157 30361813-13 2019 CONCLUSIONS: Paeoniflorin inhibits the migration- and invasion-promoting capacities of GCAFs by targeting microRNA-149 and IL-6. peoniflorin 13-25 interleukin 6 Homo sapiens 123-127 31513981-9 2019 Plasma IL-6 levels were significantly associated with plasma morphine levels (P = 0.005) and urinary morphine-positive (+) results (P = 0.04), and significantly associated with poor compliance (P = 0.009) and early dropout from MMT (P = 0.001). mmt 228-231 interleukin 6 Homo sapiens 7-11 31553301-15 2019 ML1899 enhanced ROS/NO production and up-regulated pro-inflammatory cytokines and chemokine including TNF-alpha, IFN-gamma, IL-6 and IL-8 in macrophages. A 1899 0-6 interleukin 6 Homo sapiens 124-128 31639165-9 2019 Glycerol also induced the high expression of proinflammatory cytokine IL-1beta and IL-6 in kidney and human renal proximal tubule HK-2 cells. Glycerol 0-8 interleukin 6 Homo sapiens 83-87 31695615-9 2019 The plasma levels of IL-1beta, IL-6, TNF-alpha, HMGB1, and netrin-1 were significantly reduced with the treatment of minocycline. Minocycline 117-128 interleukin 6 Homo sapiens 31-35 31619000-0 2019 6-Shogaol Inhibits Advanced Glycation End-Products-Induced IL-6 and ICAM-1 Expression by Regulating Oxidative Responses in Human Gingival Fibroblasts. shogaol 0-9 interleukin 6 Homo sapiens 59-63 31619000-9 2019 The AGEs-stimulated expression levels of receptor of AGE (RAGE), IL-6 and ICAM-1 and the phosphorylation of p38, ERK and p65 were attenuated by 6-shogaol. shogaol 144-153 interleukin 6 Homo sapiens 65-69 31505164-12 2019 E804 also affected expression of il6, vegfa, and stat3. CHEMBL1276317 0-4 interleukin 6 Homo sapiens 33-36 30997931-6 2019 VCZ-Cmin at different concentration range showed significant inhibitory effect of IL-6. vcz-cmin 0-8 interleukin 6 Homo sapiens 82-86 31280036-7 2019 The TBI with LOC group also had significantly elevated IL-6 concentrations than both TBI without LOC and control groups. Thioacetazone 4-7 interleukin 6 Homo sapiens 55-59 31022551-4 2019 Our studies identified the natural product calcaratarin D (1) as a promising anti-inflammatory agent, which effectively modulates the production of pro-inflammatory mediators (e.g., TNF-alpha, IL-6, NO) at both transcriptional and translational levels. calcaratarin D 43-57 interleukin 6 Homo sapiens 193-197 31252632-6 2019 At baseline, urinary ADMA, DMA, and SDMA excretion correlated positively with circulating TNF-alpha and IL-6. symmetric dimethylarginine 36-40 interleukin 6 Homo sapiens 104-108 30849307-10 2019 Quercetin treatment mitigated the LPS-caused inflammatory damage of WI-38 lung fibroblasts via enhancing cell viability, inhibiting cell apoptosis and reducing the production of inflammatory cytokines IL-6 and TNF-a. Quercetin 0-9 interleukin 6 Homo sapiens 201-205 30999647-6 2019 The results showed that DHL inhibited LPS-induced production of proinflammatory mediators such as iNOS, NO, and cytokines including TNF-alpha, IL-6, IL-1beta, and IL-12 p35 by suppressing the activity of NF-kappaB via p38 MAPK/MK2 and Akt signaling pathway in macrophages. dehydrocostus lactone 24-27 interleukin 6 Homo sapiens 143-147 30484006-8 2019 Furthermore, macrophages showed no cytotoxicity after PDA extract treatment with or without LPS, while the release levels of TNF-alpha and IL-6 by LPS-induced macrophages were decreased in dose-dependent by PDA extract treatment. polydopamine 207-210 interleukin 6 Homo sapiens 139-143 30465781-2 2019 The HSF enhanced uptake and transport of fluticasone propionate across the epithelial barrier when alone and in presence of salmeterol. Salmeterol Xinafoate 124-134 interleukin 6 Homo sapiens 4-7 32255011-0 2019 Bead-type polystyrene/nano-CaCO3 (PS/nCaCO3) composite: a high-performance adsorbent for the removal of interleukin-6. ncaco3 37-43 interleukin 6 Homo sapiens 104-117 32255011-3 2019 It was revealed that the incorporation of nCaCO3 into the PS matrix enhanced both the mechanical strength which can prevent the fragmentation and its adsorption capacity for interleukin-6 (IL-6, MW = 24.0 kDa) from human plasma. ncaco3 42-48 interleukin 6 Homo sapiens 174-187 32255011-3 2019 It was revealed that the incorporation of nCaCO3 into the PS matrix enhanced both the mechanical strength which can prevent the fragmentation and its adsorption capacity for interleukin-6 (IL-6, MW = 24.0 kDa) from human plasma. ncaco3 42-48 interleukin 6 Homo sapiens 189-193 30201373-7 2019 The increase of sdLDL was correlated with the presence of IR and IL-6 levels. sdldl 16-21 interleukin 6 Homo sapiens 65-69 30597391-8 2019 Elevated blood Pb, urinary 2-hydroxynaphthalene (2-OHNap) and SigmaOHFlu levels were associated with higher levels of IL-6, IL-12p70, IP-10, CD4+ T cell percentages, neutrophil and monocyte counts. 2-ohnap 49-56 interleukin 6 Homo sapiens 118-122 30961685-4 2019 Micheliolide (MCL), a guaianolide sesquiterpene lactone, possesses anti-inflamma tory properties and can attenuate the IL-6 level. micheliolide 0-12 interleukin 6 Homo sapiens 119-123 30873416-8 2019 These positive data are contrasted with neutral evidence from CIRT in which low-dose methotrexate neither reduced the critical IL-1beta to IL-6 to CRP pathway of innate immunity, nor reduced cardiovascular event rates. Methotrexate 85-97 interleukin 6 Homo sapiens 139-143 30518662-10 2019 Combined assessment of interleukin-6 and clinical judgment increased the AUC at presentation to 0.83 (95% CI, 0.80-0.85) and after imaging to 0.87 (95% CI, 0.84-0.89) and improved the correct identification of patients with and without UAP (net improvement in mean predicted probability: presentation, +19%; after imaging, +15%; P < 0.001). 4-Deoxy-2-O-Sulfo-Alpha-L-Threo-Hex-4-Enopyranuronic Acid 236-239 interleukin 6 Homo sapiens 23-36 30530051-7 2019 RESULTS: Midazolam suppressed LPS-induced upregulation of CD80 and release of IL-6 and NO in THP-1 cells and PMDMs. Midazolam 9-18 interleukin 6 Homo sapiens 78-82 31146075-10 2019 RESULTS: ELISA analyses showed that the whole Micra system leads to a significant increase in the inflammatory cytokine IL-6 which correlates with the data gained by the incubation of whole blood with the different wires. micra 46-51 interleukin 6 Homo sapiens 120-124 30959503-7 2019 RESULTS: Uremic serum increased the expression of the following genes: IL6 +97%, p < 0.002; VEGF +28%, p < 0.002; vWF +47%, p < 0.002; PECAM +76%, p < 0.002; ICAM-1 +275%, p < 0.002; t-PA +96%, p < 0.002. t-pa 198-202 interleukin 6 Homo sapiens 71-74 29235373-8 2018 IL-6 was significantly associated with glycerol in all models (p < .05), with glycerol levels increasing by 106% in individuals with AGM after AP (p <.05) compared to a 30.3% increase in individuals with normal glucose metabolism (NGM) (p >.05). Glycerol 39-47 interleukin 6 Homo sapiens 0-4 29235373-8 2018 IL-6 was significantly associated with glycerol in all models (p < .05), with glycerol levels increasing by 106% in individuals with AGM after AP (p <.05) compared to a 30.3% increase in individuals with normal glucose metabolism (NGM) (p >.05). Glycerol 81-89 interleukin 6 Homo sapiens 0-4 30229288-0 2018 Lysophosphatidylcholine induces cyclooxygenase-2-dependent IL-6 expression in human cardiac fibroblasts. Lysophosphatidylcholines 0-23 interleukin 6 Homo sapiens 59-63 30229288-1 2018 Lysophosphatidylcholine (LysoPC) has been shown to induce the expression of inflammatory proteins, including cyclooxygenase-2 (COX-2) and interleukin-6 (IL-6), associated with cardiac fibrosis. Lysophosphatidylcholines 0-23 interleukin 6 Homo sapiens 138-151 30229288-1 2018 Lysophosphatidylcholine (LysoPC) has been shown to induce the expression of inflammatory proteins, including cyclooxygenase-2 (COX-2) and interleukin-6 (IL-6), associated with cardiac fibrosis. Lysophosphatidylcholines 0-23 interleukin 6 Homo sapiens 153-157 30229288-1 2018 Lysophosphatidylcholine (LysoPC) has been shown to induce the expression of inflammatory proteins, including cyclooxygenase-2 (COX-2) and interleukin-6 (IL-6), associated with cardiac fibrosis. Lysophosphatidylcholines 25-31 interleukin 6 Homo sapiens 138-151 30229288-1 2018 Lysophosphatidylcholine (LysoPC) has been shown to induce the expression of inflammatory proteins, including cyclooxygenase-2 (COX-2) and interleukin-6 (IL-6), associated with cardiac fibrosis. Lysophosphatidylcholines 25-31 interleukin 6 Homo sapiens 153-157 30390648-6 2018 RESULTS: Challenge with the omega-6 PUFA arachidonic acid (AA), but not omega-3 PUFAs or SFAs, resulted in increased IL-6 and CXCL8 release from fibroblasts, however IL-6 and CXCL8 release was reduced in COPD (n = 19) compared to non-COPD (n = 36). omega-6 pufa 28-40 interleukin 6 Homo sapiens 117-121 30390648-6 2018 RESULTS: Challenge with the omega-6 PUFA arachidonic acid (AA), but not omega-3 PUFAs or SFAs, resulted in increased IL-6 and CXCL8 release from fibroblasts, however IL-6 and CXCL8 release was reduced in COPD (n = 19) compared to non-COPD (n = 36). omega-6 pufa 28-40 interleukin 6 Homo sapiens 166-170 30292410-6 2018 Moreover, we demonstrated that the levels of IL-6 and IL-23 were markedly downregulated in ANXA1-silenced and BTZ-treated MM cells. Bortezomib 110-113 interleukin 6 Homo sapiens 45-49 30077906-7 2018 MCN, MCN-PVP and MCN-PEG promoted the differentiation and maturation of the DCs, while the levels of secreted TNF-alpha and IL-6 were significantly suppressed by MCN-PVP and MCN-PEG. mcn-pvp 162-169 interleukin 6 Homo sapiens 124-128 29407194-4 2018 A selective alpha1-ADR agonist, phenylephrine, increased intracellular Ca2+-levels in cultured HTPCs and induced COX-2, IL-6 and MCP-1 mRNA expression without affecting IL-1beta mRNA. Phenylephrine 32-45 interleukin 6 Homo sapiens 120-124 30196838-3 2018 In this study, we show that Honokiol reduces the inflammatory response to LPS of primary cultures of microglia and astrocytes through the inhibition of pro-inflammatory mediators (iNOS, IL-6, IL-1beta and TNF-alpha) and the simultaneous stimulation of anti-inflammatory cytokines (IL-10). honokiol 28-36 interleukin 6 Homo sapiens 186-190 30285183-12 2018 Early treatment with methotrexate plus glucocorticoids and subsequently with other DMARDs, such as inhibitors of TNF, IL-6, or Janus kinases, improves outcomes and prevents RA-related disability. Methotrexate 21-33 interleukin 6 Homo sapiens 118-122 30206205-7 2018 TNFR2/ZVAD-induced production of IL-6 and IL-1beta was largely blocked in necroptosis-resistant MLKL- and RIPK3-deficient macrophages, whereas induction of A20 and TRAF1 remained unaffected. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 6-10 interleukin 6 Homo sapiens 33-37 29794822-7 2018 Five metabolic-inflammatory genes exhibited significantly different expression levels between purified monocytes of the ZDV and TDF groups (IL-6, 2.90-fold lower in ZDV group, P < 0.001; iNOS, 1.81-fold higher; CX3CR1, 1.72-fold lower; MIP-1beta, 1.10-fold lower; and PPARgamma-1, 1.36-fold higher, P < 0.05). Zidovudine 120-123 interleukin 6 Homo sapiens 140-144 29870142-9 2018 Aberrant cytokine profiles were secreted by SAA MSCs, with increased concentrations of interleukin-6, interferon-gamma, tumor necrosis factor-alpha, and interleukin-1beta in the CM. saa 44-47 interleukin 6 Homo sapiens 87-100 30154433-0 2018 ID1-induced p16/IL6 axis activation contributes to the resistant of hepatocellular carcinoma cells to sorafenib. Sorafenib 102-111 interleukin 6 Homo sapiens 16-19 29803913-0 2018 Combination of 4-hydroperoxy cyclophosphamide and methotrexate inhibits IL-6/sIL-6R-induced RANKL expression in fibroblast-like synoviocytes via suppression of the JAK2/STAT3 and p38MAPK signaling pathway. Methotrexate 50-62 interleukin 6 Homo sapiens 72-76 29803913-4 2018 Using western blotting, real-time polymerase chain reaction, enzyme-linked immunosorbent assays, and immunofluorescent staining, we demonstrated that the combination of 4-hydroperoxy CTX (4-H-CTX) and MTX inhibited the expression of receptor activator of nuclear factor-kappaB ligand (RANKL) in fibroblast-like synoviocytes (FLS) treated with the interleukin (IL)-6/soluble IL-6 receptor (sIL-6R) complex. Methotrexate 201-204 interleukin 6 Homo sapiens 374-378 29803913-6 2018 The results showed that IL-6/sIL-6R-induced RANKL upregulation required phosphorylation-mediated activation of STAT3 and p38 signaling, and that 4-H-CTX and/or MTX inhibited RANKL expression in IL-6/sIL-6R-stimulated FLS by suppressing JAK2/STAT3 and p38MAPK signaling. Methotrexate 160-163 interleukin 6 Homo sapiens 24-28 29913427-3 2018 Results showed that formononetin significantly reduced the production of TNF-alpha, IL-6 and IL-1beta, nitrite and PGE2, as well as protein levels of iNOS and COX-2. formononetin 20-32 interleukin 6 Homo sapiens 84-88 30105015-2 2018 CRP is a phosphocholine (PC)-binding pentraxin, mainly produced in the liver in response to elevated levels of interleukin-1beta (IL-1beta) and of the IL-1beta-dependent cytokine IL-6. Phosphorylcholine 25-27 interleukin 6 Homo sapiens 179-183 28923363-4 2018 In fact, pure flavonoids (e.g., quercetin, genistein, hesperetin, epigallocatechin-3-gallate) or enriched-extracts, can reduce the expression of pro-inflammatory cytokines (IL-6, TNF-alpha, IL-1beta and COX-2), down-regulate inflammatory markers and prevent neural damage. Flavonoids 14-24 interleukin 6 Homo sapiens 173-177 28923363-4 2018 In fact, pure flavonoids (e.g., quercetin, genistein, hesperetin, epigallocatechin-3-gallate) or enriched-extracts, can reduce the expression of pro-inflammatory cytokines (IL-6, TNF-alpha, IL-1beta and COX-2), down-regulate inflammatory markers and prevent neural damage. Quercetin 32-41 interleukin 6 Homo sapiens 173-177 29368548-5 2018 We found that the omega-6 PUFA arachidonic acid (AA), but not omega-3 PUFAs or SFAs, upregulates IL-6 and CXCL8 release. omega-6 pufa 18-30 interleukin 6 Homo sapiens 97-101 29704403-6 2018 In differentiated Caco-2 cell monolayers as a model of the small intestinal epithelium, complexation of gliadin with GTE reduces gliadin-stimulated monolayer permeability and the release of interleukin (IL)-6 and IL-8. gte 117-120 interleukin 6 Homo sapiens 190-208 29808005-5 2018 CRS may respond to IL-6 receptor blockade but can require further treatment with high dose corticosteroids to curb potentially lethal severity2-9. 3-cresol 0-3 interleukin 6 Homo sapiens 19-23 29808005-7 2018 Here we report a murine model of CRS that develops within 2-3 d of CAR T cell infusion and that is potentially lethal and responsive to IL-6 receptor blockade. 3-cresol 33-36 interleukin 6 Homo sapiens 136-140 29693175-13 2018 The expression levels of vascular endothelial growth factor (VEGF), interleukin 6 (IL-6) and basic fibroblast growth factor (bFGF) were reduced in the MVs from the RPMI-8226 cells exposed to bortezomib and lenalidomide. Bortezomib 191-201 interleukin 6 Homo sapiens 68-81 29693175-13 2018 The expression levels of vascular endothelial growth factor (VEGF), interleukin 6 (IL-6) and basic fibroblast growth factor (bFGF) were reduced in the MVs from the RPMI-8226 cells exposed to bortezomib and lenalidomide. Bortezomib 191-201 interleukin 6 Homo sapiens 83-87 29849089-5 2018 Furthermore, we show that hippuristanol perturbs the activation of the STAT3 pathway and expression of STAT3-gene targets such as IL-6. hippuristanol 26-39 interleukin 6 Homo sapiens 130-134 29486150-0 2018 Novel fused oxazepino-indoles (FOIs) attenuate liver carcinogenesis via IL-6/JAK2/STAT3 signaling blockade as evidenced through data-based mathematical modeling. oxazepino-indoles 12-29 interleukin 6 Homo sapiens 72-76 29469972-8 2018 RESULTS: TEOM models incubated at 20 C showed an increased cell viability and had a reduced IL-6 and TNF-alpha production compared to models treated with 5-FU incubated at 35 C. CONCLUSION: This study demonstrates a reduced cytotoxic effect to the TEOM by reducing the temperature of the tissue during chemotherapy treatment and suggests that decreasing the temperature to 20 C could have clinical advantages. teom 9-13 interleukin 6 Homo sapiens 92-96 29565447-0 2018 CAFs enhance paclitaxel resistance by inducing EMT through the IL-6/JAK2/STAT3 pathway. cafs 0-4 interleukin 6 Homo sapiens 63-67 29565447-17 2018 We found that CAFs were the main source of IL-6 in ovarian cancer tissue. cafs 14-18 interleukin 6 Homo sapiens 43-47 29565447-21 2018 Univariate and multivariate analyses revealed that age, CA125, interstitial IL-6 expression and cytoreduction satisfaction were closely related to the sensitivity of the TP (docetaxel plus cisplatin or carbopatin) regimen in ovarian cancer (P<0.05). Docetaxel 174-183 interleukin 6 Homo sapiens 76-80 29565447-22 2018 These results demonstrated that CAFs highly secreted IL-6 and promoted beta-TGF-mediated EMT in ovarian cancer via the JAK2/STAT3 pathway, leading to inhibited apoptosis and subsequent paclitaxel resistance. cafs 32-36 interleukin 6 Homo sapiens 53-57 29495390-4 2018 In this report, we found that aloin suppresses lipopolysaccharide-induced pro-inflammatory cytokine secretion and nitric oxide production, and downregulates the expression of tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2). alloin 30-35 interleukin 6 Homo sapiens 216-229 29495390-4 2018 In this report, we found that aloin suppresses lipopolysaccharide-induced pro-inflammatory cytokine secretion and nitric oxide production, and downregulates the expression of tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2). alloin 30-35 interleukin 6 Homo sapiens 231-235 29362444-13 2018 Additionally, there was a significant 3-way interaction between aspirin, minocycline, and IL-6, indicating that response to minocycline was significantly greater in participants in the M + P group with higher IL-6 concentrations. Minocycline 124-135 interleukin 6 Homo sapiens 90-94 29362444-13 2018 Additionally, there was a significant 3-way interaction between aspirin, minocycline, and IL-6, indicating that response to minocycline was significantly greater in participants in the M + P group with higher IL-6 concentrations. Minocycline 124-135 interleukin 6 Homo sapiens 209-213 30734678-6 2018 RESULTS: (DCN-2) incubation with 120nM to the normal neutrophil solution for 2h resulted in the increase of TNF-alpha from 3.82+-1.53pg/ml to 20.7+-6.9pg/ml and IL-6 from 3.27+-1.52pg/ml to 47.07+-3.4pg/ml. Deuterium 77-79 interleukin 6 Homo sapiens 161-165 29398016-15 2018 The allergens (Der p2 and Der p3)-induced IL-6/IL-8 expression and NCA released from Beas-2B could be downregulated by dexamethasone and transcription factor inhibitor SP600125. pyrazolanthrone 168-176 interleukin 6 Homo sapiens 42-46 28858391-6 2018 Further study indicated that UVB-induced production of MMP-1 and IL-6 could be inhibited by PD 98059 (an ERK inhibitor) and SP600125 (A JNK inhibitor), implied that EPS inhibited UVB-induced MMP-1 and IL-6 secretion by inactivating MAPK signaling pathway. pyrazolanthrone 124-132 interleukin 6 Homo sapiens 65-69 29594564-0 2017 Photoelectrochemical immunoassay for human interleukin 6 based on the use of perovskite-type LaFeO3 nanoparticles on fluorine-doped tin oxide glass. lanthanum iron oxide 93-99 interleukin 6 Homo sapiens 43-56 28990058-7 2017 The results demonstrated that MCP-1 and IL-6 secretion, as well as TNF-alpha expression, were significantly increased following FFA treatment, which was attenuated by Rb1 in a dose-dependent manner. Fatty Acids, Nonesterified 128-131 interleukin 6 Homo sapiens 40-44 29165341-7 2017 Finally, H2O2-EVs were capable of eliciting an increased interleukin 6 mRNA expression in RAW264.7 macrophages. h2o2-evs 9-17 interleukin 6 Homo sapiens 57-70 27846790-4 2017 FINDINGS: Administration of ROS and ATO both significantly reduced the concentrations of TC, LDL-C, TG, hs-CRP, and IL-6, but increased high-density lipoproteincholesterol (HDL-C), ALB, PA, and TF levels. Rosuvastatin Calcium 28-31 interleukin 6 Homo sapiens 116-120 25359504-1 2017 AIM: In multiple myeloma (MM), the growth and survival of myeloma cells is controlled by interleukin-6 (IL-6), the plasma levels of which is controlled by a guanine/cytosine substitution occurring in position -174 of IL-6 gene promoter region. Guanine 157-164 interleukin 6 Homo sapiens 89-102 25359504-1 2017 AIM: In multiple myeloma (MM), the growth and survival of myeloma cells is controlled by interleukin-6 (IL-6), the plasma levels of which is controlled by a guanine/cytosine substitution occurring in position -174 of IL-6 gene promoter region. Guanine 157-164 interleukin 6 Homo sapiens 104-108 25359504-1 2017 AIM: In multiple myeloma (MM), the growth and survival of myeloma cells is controlled by interleukin-6 (IL-6), the plasma levels of which is controlled by a guanine/cytosine substitution occurring in position -174 of IL-6 gene promoter region. Guanine 157-164 interleukin 6 Homo sapiens 217-221 25359504-1 2017 AIM: In multiple myeloma (MM), the growth and survival of myeloma cells is controlled by interleukin-6 (IL-6), the plasma levels of which is controlled by a guanine/cytosine substitution occurring in position -174 of IL-6 gene promoter region. Cytosine 165-173 interleukin 6 Homo sapiens 89-102 25359504-1 2017 AIM: In multiple myeloma (MM), the growth and survival of myeloma cells is controlled by interleukin-6 (IL-6), the plasma levels of which is controlled by a guanine/cytosine substitution occurring in position -174 of IL-6 gene promoter region. Cytosine 165-173 interleukin 6 Homo sapiens 104-108 25359504-1 2017 AIM: In multiple myeloma (MM), the growth and survival of myeloma cells is controlled by interleukin-6 (IL-6), the plasma levels of which is controlled by a guanine/cytosine substitution occurring in position -174 of IL-6 gene promoter region. Cytosine 165-173 interleukin 6 Homo sapiens 217-221 29100435-2 2017 Experimental Design: IL-6 was disrupted by transcription activator-like effector nucleases (TALEN) in HCCLM3 cells, and was used to evaluate the role of IL-6 on tumor cell proliferation, apoptosis, invasion and key signaling pathways involved in sorafenib and/or IFNalpha therapy. Sorafenib 246-255 interleukin 6 Homo sapiens 21-25 29100435-4 2017 IL-6 could attenuate the anti-proliferation effect by sorafenib and combination therapy but facilitate the pro-apoptosis of the combination therapy and augment the pro-invasive effect induced by single treatment. Sorafenib 54-63 interleukin 6 Homo sapiens 0-4 29100435-5 2017 IL-6 could down-regulate p-STAT3, however up-regulate the p-MEK/p-ERK and NF-kB/iNOS expression, and it also facilitated the promotion on p-JAK2 and p-MEK/p-ERK by either sorafenib or IFN-alpha. Sorafenib 171-180 interleukin 6 Homo sapiens 0-4 29100435-9 2017 Sorafenib and combination therapies are suitable for HCC cells with low or no IL-6 expression confirmed in vivo study. Sorafenib 0-9 interleukin 6 Homo sapiens 78-82 28650029-8 2017 The present study shows that the amine-modified MSNs could encapsulate BA and BE, and nano-encapsulation greatly enhances the drug delivery rate and prolongs the release of BA and BE up to 216 h. Moreover, both Nano-BA and Nano-BE could be internalized by hGECs and retained intracellularly in nanoparticle-free media for at least 24 h. Note that Nano-BE pre-treatment effectively down-regulates the IL-1beta-induced expression of IL-6 and IL-8 in hGECs. Amines 33-38 interleukin 6 Homo sapiens 431-435 29137334-9 2017 In addition, combined treatment with sorafenib and kahweol markedly induced apoptosis in human lung carcinoma (A549) and breast carcinoma (MDA-MB-361) cells, but not in human normal mesangial cells and human skin fibroblast cells (HSF). Sorafenib 37-46 interleukin 6 Homo sapiens 231-234 29137334-9 2017 In addition, combined treatment with sorafenib and kahweol markedly induced apoptosis in human lung carcinoma (A549) and breast carcinoma (MDA-MB-361) cells, but not in human normal mesangial cells and human skin fibroblast cells (HSF). kahweol 51-58 interleukin 6 Homo sapiens 231-234 29109769-9 2017 In addition, DCZ3301 inhibited VEGF and IL-6 secretion in a dose-dependent fashion in a co-culture of MM cells and BMSCs. DCZ3301 13-20 interleukin 6 Homo sapiens 40-44 27866306-6 2017 The inhibitor of NF-kappaB (BAY 11-7082), but not PD98059 (PD, ERK1/2 inhibitor) or LY294002 (LY, PI3 K/Akt inhibitor), attenuated BPA-induced IL-6 expression and cell proliferation and invasion. 3-(4-methylphenylsulfonyl)-2-propenenitrile 28-39 interleukin 6 Homo sapiens 143-147 28677802-4 2017 In this study, HCC EMT was induced by the treatment of IL-6 and various concentrations of NCTD (0, 30, 60 and 120 microM) were treated with HCC cell lines, HCCLM3 and SMMC-7721. smmc 167-171 interleukin 6 Homo sapiens 55-59 28515148-3 2017 E+P treatment of patient-derived epithelial cells derived from ductal carcinoma in situ (DCIS) increased secretion of the proinflammatory cytokine IL6. e+p 0-3 interleukin 6 Homo sapiens 147-150 28515148-5 2017 Accordingly, E+P treatment of breast cancer cells increased ER binding to the NEMO promoter, thereby increasing NEMO expression, NFkappaB activation, and IL6 secretion. e+p 13-16 interleukin 6 Homo sapiens 154-157 28456711-9 2017 In vitro, paeoniflorin significantly inhibited the mRNA expression of IL-6, IL-17A and IL-22 at both 2.08 and 10.41muM (p<0.01), and paeoniflorin had a marginal effect on the protein expression of IL-17A and IL-6. peoniflorin 10-22 interleukin 6 Homo sapiens 70-74 28456711-9 2017 In vitro, paeoniflorin significantly inhibited the mRNA expression of IL-6, IL-17A and IL-22 at both 2.08 and 10.41muM (p<0.01), and paeoniflorin had a marginal effect on the protein expression of IL-17A and IL-6. peoniflorin 10-22 interleukin 6 Homo sapiens 211-215 28693192-3 2017 The results demonstrated that QNZ and regorafenib significantly reduced the expression and secretion levels of the angiogenesis- and metastasis-associated proteins vascular endothelial growth factor, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, matrix metalloproteinase (MMP)-2 and MMP-9, NF-kappaB activation and cell invasion. EVP 4593 30-33 interleukin 6 Homo sapiens 253-257 28636670-7 2017 Of the four hits, KI16 stood out as the most promising compound, inhibiting STAT3 phosphorylation and transcriptional activity in response to IL6 stimulation. ki16 18-22 interleukin 6 Homo sapiens 142-145 28467797-0 2017 Synergistic inhibition effect of TNIK inhibitor KY-05009 and receptor tyrosine kinase inhibitor dovitinib on IL-6-induced proliferation and Wnt signaling pathway in human multiple myeloma cells. 5-(4-methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide 48-56 interleukin 6 Homo sapiens 109-113 28467797-0 2017 Synergistic inhibition effect of TNIK inhibitor KY-05009 and receptor tyrosine kinase inhibitor dovitinib on IL-6-induced proliferation and Wnt signaling pathway in human multiple myeloma cells. 4-amino-5-fluoro-3-(5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl)quinolin-2(1H)-one 96-105 interleukin 6 Homo sapiens 109-113 28475276-12 2017 Initiation of MTX was associated with reductions in IL-1alpha (p=0.009), IL-1beta (p=0.01), IL-1Ra (p=0.007), and IL-6 (p=0.03) levels; however, reductions in JADAS were only associated with reductions in IL-6 (p=0.009) and TNF-alpha levels (p=0.02). Methotrexate 14-17 interleukin 6 Homo sapiens 114-118 28475276-12 2017 Initiation of MTX was associated with reductions in IL-1alpha (p=0.009), IL-1beta (p=0.01), IL-1Ra (p=0.007), and IL-6 (p=0.03) levels; however, reductions in JADAS were only associated with reductions in IL-6 (p=0.009) and TNF-alpha levels (p=0.02). Methotrexate 14-17 interleukin 6 Homo sapiens 205-209 28625239-9 2017 RESULTS: Compared with the sham group, the mRNA and protein expressions of IL-6 in myocardium in AMI model group were increased significantly (gray value: 0.732+-0.131 vs. 0.321+-0.080, 0.678+-0.191 vs. 0.286+-0.061, both P < 0.05). amicoumacin A 97-100 interleukin 6 Homo sapiens 75-79 28625239-10 2017 Compared with the AMI model group, the mRNA and protein expressions of IL-6 in myocardium in UC-MSCs group were decreased significantly (gray value: 0.300+-0.104 vs. 0.732+-0.131, 0.312+-0.101 vs. 0.678+-0.191, both P < 0.05). amicoumacin A 18-21 interleukin 6 Homo sapiens 71-75 28625239-12 2017 CONCLUSIONS: Human UC-MSCs could promote angiogenesis by the improvement of VEGF in coronary artery and inhibit the inflammation by the reduction of IL-6 in rats with AMI. amicoumacin A 167-170 interleukin 6 Homo sapiens 149-153 27841868-0 2017 Long noncoding RNA-SRLR elicits intrinsic sorafenib resistance via evoking IL-6/STAT3 axis in renal cell carcinoma. Sorafenib 42-51 interleukin 6 Homo sapiens 75-79 27841868-5 2017 Mechanistically, lncRNA-SRLR directly binds to NF-kappaB and promotes IL-6 transcription, leading to the activation of STAT3 and the development of sorafenib tolerance. Sorafenib 148-157 interleukin 6 Homo sapiens 70-74 27841868-6 2017 A STAT3 inhibitor and IL-6-receptor antagonist both restored the response to sorafenib treatment. Sorafenib 77-86 interleukin 6 Homo sapiens 22-26 28120534-5 2017 Moreover, sulforaphane markedly suppressed the expression of IL-6 and alpha-SMA and inhibited Stat3 and Smad3 signaling pathways in keloid fibroblast KF112 cells. sulforaphane 10-22 interleukin 6 Homo sapiens 61-65 28120534-8 2017 Furthermore, sulforaphane suppressed IL-6, Stat3, and Smad3 signaling in the coculture system. sulforaphane 13-25 interleukin 6 Homo sapiens 37-41 28284222-6 2017 Upon treatment with teriflunomide, cytokine secretion was decreased (CXCL10, 3-fold; CCL2, 2.5-fold; IL-6, 2.2-fold; p < 0.001) and monomethylfumarate treatment led to 2.9-fold lower CXCL10 secretion (p < 0.001). teriflunomide 20-33 interleukin 6 Homo sapiens 101-105 28042053-7 2017 In Hfsmc, elocalcitol exerted an I-like effect, promoting GLUT4 re-localization in Flotillin-1, Caveolin-3 and Caveolin-1 positive sites and mTOR, AKT, ERK, 4E-BP1 activation; it enhanced IL-6 myokine release. BXL628 10-21 interleukin 6 Homo sapiens 188-192 28260873-10 2017 COPD patients with CRS had a higher percentage of eosinophils, higher levels of IL-8, IL-6, and MMP-9 in sputum as compared to those without CRS. 3-cresol 19-22 interleukin 6 Homo sapiens 86-90 28260873-11 2017 In COPD-Bx patients with CRS, the percentage of eosinophils and the levels of IL-6 and MMP-9 in sputum were increased as compared to those without CRS. 3-cresol 25-28 interleukin 6 Homo sapiens 78-82 28187727-11 2017 We also found that ATO combined with CT reversed the upregulated expression of phosphorylated-STAT3Tyr705 stimulated by interleukin-6 and downregulated STAT3 direct target genes and the anti-apoptotic proteins Bcl-2, XIAP, and survivin but obviously upregulated the promoting apoptosis proteins Bak,.In vivo studies showed that ATO combined with CT decreased tumor growth. Arsenic Trioxide 19-22 interleukin 6 Homo sapiens 120-133 27510419-7 2017 Four-day treatment with dextran sulphate sodium (DSS) triggered colon inflammation, as evidenced by an increase in local IL6 and mKC mRNA levels, but did not affect the gross architecture of colonic epithelium. dss 49-52 interleukin 6 Homo sapiens 121-124 29147463-5 2017 Furthermore, ASP inhibited NF-kappaB p65 activation via the IkappaB kinases- (IKKs-) IkappaBalpha pathway, thereby reducing the secretion of interleukin-6 (IL-6) and TNF-alpha, which is known to inhibit erythropoiesis. Aspartic Acid 13-16 interleukin 6 Homo sapiens 141-154 29147463-5 2017 Furthermore, ASP inhibited NF-kappaB p65 activation via the IkappaB kinases- (IKKs-) IkappaBalpha pathway, thereby reducing the secretion of interleukin-6 (IL-6) and TNF-alpha, which is known to inhibit erythropoiesis. Aspartic Acid 13-16 interleukin 6 Homo sapiens 156-160 27476063-3 2016 The aim of this study was to identify relationship between IL-6 -174G/C gene polymorphisms and clinical features, disease severity score (DSS) and proteinuria in children diagnosed with FMF. dss 138-141 interleukin 6 Homo sapiens 59-63 27449264-9 2016 Treatment with PI3K inhibitor ZSTK474 or STAT3 inhibitor niclosamide reversed the effects of WSTF overexpression by inhibiting cell proliferation, migration and invasion, with decreased level of p-Akt, p-STAT3 and IL-6. Niclosamide 57-68 interleukin 6 Homo sapiens 214-218 26609631-0 2016 Quercetin inhibits multiple pathways involved in interleukin 6 secretion from human lung fibroblasts and activity in bronchial epithelial cell transformation induced by benzo[a]pyrene diol epoxide. Quercetin 0-9 interleukin 6 Homo sapiens 49-62 27491751-0 2016 Poligalen, a new coumarin from Polygala boliviensis, reduces the release of TNF and IL-6 independent of NF-kB downregulation. coumarin 17-25 interleukin 6 Homo sapiens 84-88 27018002-0 2016 9- and 13-Hydroxy-octadecadienoic acids (9+13 HODE) are inversely related to granulocyte colony stimulating factor and IL-6 in runners after 2h running. Deuterium 141-143 interleukin 6 Homo sapiens 119-123 27235090-4 2016 Fortepren( ) treatment of patients with a high incidence of recurrent herpes infection led to an increase in the interferon-producing ability of leucocytes stimulated with NDV, as well as in the production of key cytokines (IL-1beta, IL-15, MIP-1alpha, IFN-gamma, IL-12 (p40), TNF-alpha, IFN-alpha2, IL-12 (p70), IL-6) taking part in the protection against viral infection. fortepren 0-9 interleukin 6 Homo sapiens 313-317 27410685-5 2016 In a DSS-induced acute colitis model, CHST15 siRNA reduced CHST15 mRNA in the colon, serum IL-6, disease activity index (DAI) and accumulation of F4/80+ macrophages and ER-TR7+ fibroblasts, while increased Ki-67+ epithelial cells. Dextran Sulfate 5-8 interleukin 6 Homo sapiens 91-95 26965667-6 2016 IL-6 protein detected in the medium of pAVPCs treated with TBT at both doses studied and with a dose response. tributyltin 59-62 interleukin 6 Homo sapiens 0-4 25532488-6 2016 OTA-induced NO, TNF-alpha, IL-6, and IL-8 were significantly reduced in the quercetin pretreated samples indicating its anti-inflammatory role. Quercetin 76-85 interleukin 6 Homo sapiens 27-31 27020921-9 2016 IL-6 and IL-10 levels significantly increased, while IFN-gamma level decreased in both groups during the surgery and 3 days after the surgery compared to those before the surgery; 2 weeks after the surgery, IL-6 and IL-10 levels in the MIE group recovered to the pre-operative levels (all P < 0.05). mie 236-239 interleukin 6 Homo sapiens 207-211 27278808-10 2016 Z-MWCNTs released Zn(+2) ions in media and increased IL-6, IL-1beta, CXCL10, and TNF-alpha mRNAs in THP-1 cells in vitro. z-mwcnts 0-8 interleukin 6 Homo sapiens 53-57 27000882-2 2016 Aldosterone induced productions of reactive oxygen species (ROS), OPN, interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-alpha) and expression of nicotinamide adenine dinucleotide phosphate-oxidase 4 (Nox4), NF-kappaB, OPN, alphavbeta3 (alphavbeta3) integrin, and inhibitor of NF-kappaB alpha phosphorylation (P-IkappaBalpha) in HUVEC. Aldosterone 0-11 interleukin 6 Homo sapiens 71-84 27000882-2 2016 Aldosterone induced productions of reactive oxygen species (ROS), OPN, interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-alpha) and expression of nicotinamide adenine dinucleotide phosphate-oxidase 4 (Nox4), NF-kappaB, OPN, alphavbeta3 (alphavbeta3) integrin, and inhibitor of NF-kappaB alpha phosphorylation (P-IkappaBalpha) in HUVEC. Aldosterone 0-11 interleukin 6 Homo sapiens 86-90 26961818-6 2016 The results suggested that, compared with observed clinical data, changes in systemic exposure to multiple CYP substrates by anti-IL-6 treatment in virtual RA patients have been reasonably captured by the PBPK model, as manifested by modulations in area under plasma concentration versus time curves for midazolam, omeprazole, S-warfarin, and caffeine. Midazolam 304-313 interleukin 6 Homo sapiens 130-134 26961818-6 2016 The results suggested that, compared with observed clinical data, changes in systemic exposure to multiple CYP substrates by anti-IL-6 treatment in virtual RA patients have been reasonably captured by the PBPK model, as manifested by modulations in area under plasma concentration versus time curves for midazolam, omeprazole, S-warfarin, and caffeine. Warfarin 327-337 interleukin 6 Homo sapiens 130-134 26687339-9 2016 RESULTS: The combination of ezetimibe plus rosuvastatin decreased total cholesterol, low-density lipoprotein cholesterol, hsCRP, IL-6, and MMP-9 levels at six and 12 months after treatment. Rosuvastatin Calcium 43-55 interleukin 6 Homo sapiens 129-133 26276563-11 2016 The results showed that the expression levels of IL-6, IL-8, TNF-alpha, and NF-kappaB which seemed to be a critical mediator in the inflammatory response tended to increase in the birds chronically treated with As2O3. Arsenic Trioxide 211-216 interleukin 6 Homo sapiens 49-53 26194374-6 2016 In the TSU-68 plus docetaxel group, PFS showed significant association with fold changes in CRP (p=0.001), IL-6 (p < .001), PDGF-BB (p=0.02), and VEGF (p=0.047) following the first treatment cycle. Docetaxel 19-28 interleukin 6 Homo sapiens 107-111 27186361-6 2016 Exendin-4 and glucose-dependent insulinotropic polypepide elicited cyclic adenosine monophosphate generation, and suppressed the lipopolysaccharide-induced gene expression of inflammatory molecules, such as interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha, in U937 human monocytes. polypepide 47-57 interleukin 6 Homo sapiens 226-271 27011164-7 2016 The ER stress inhibitor salubrinal repressed, but inducer tunicamycin enhanced, the production of IL-6, IL-8, MMP-8, and MMP-9 in hPDLCs. salubrinal 24-34 interleukin 6 Homo sapiens 98-102 26640965-6 2016 Our study shows that tianeptine attenuated the LPS-evoked inflammatory activation of microglia by decreasing the expression of proinflammatory cytokines such as IL-1beta, IL-18, IL-6 and tumor necrosis factor alpha (TNF-alpha), the release of nitric oxide (NO) and reactive oxygen species (ROS) as well as the expression of inducible nitric oxide synthase. tianeptine 21-31 interleukin 6 Homo sapiens 178-182 26883396-8 2016 JNK inhibitors, SP600125, effectively inhibited the expression of p-JNK, p-c-Jun, IL-6 and TNF-alpha. pyrazolanthrone 16-24 interleukin 6 Homo sapiens 82-86 26859566-4 2016 Although the numbers of circulating CD4 and CD20 B cells were reduced in the post-menopausal group receiving ET, we also detected a better preservation of naive B cells, decreased CD4 T cell inflammatory cytokine production, and slightly lower circulating levels of the pro-inflammatory cytokine IL-6. et 109-111 interleukin 6 Homo sapiens 296-300 26456627-8 2016 RESULTS: NecroX-5 markedly inhibited mast cell degranulation and the synthesis of eicosanoids, TNF-alpha, and IL-6 by suppressing the activation of Syk, LAT, phospholipase Cgamma1, MAP kinases, the Akt/NF-kappaB pathway, and intracellular Ca(2+) mobilization via the activation of phosphatase SHP-1. NecroX-5 9-17 interleukin 6 Homo sapiens 110-114 26732432-11 2016 In U373 cells and human primary astrocytes, the selective CK2 inhibitor CX-4945 shows a dose-dependent reduction of the IL-1beta or TNF-alpha induced MCP-1 and IL-6 secretion. silmitasertib 72-79 interleukin 6 Homo sapiens 160-164 27771935-4 2016 Eucalyptol suppresses lipopolysaccharide (LPS)-induced proinflammatory cytokine production through the action of NF-kappaB, TNF-alpha, IL-1beta, and IL-6 and the extracellular signal-regulated kinase (ERK) pathway, and reduces oxidative stress through the regulation of signaling pathways and radical scavenging. Eucalyptol 0-10 interleukin 6 Homo sapiens 149-153 26431069-7 2016 SP600125 at 10 muM significantly suppressed the production of TNF alpha IL-6. pyrazolanthrone 0-8 interleukin 6 Homo sapiens 72-76 26641525-5 2015 Berkchaetoazaphilone B (2) inhibited IL-1beta, TNFalpha, and IL-6 production in the induced inflammasome assay and was cytotoxic toward human retinoblastoma cell line Y79 (IC50 = 1.1 muM), leukemia cell lines CCRF-CEM and SR, and the melanoma cell line LOX IMVI (IC50 = 10 muM). berkchaetoazaphilone B 0-22 interleukin 6 Homo sapiens 61-65 26152744-6 2015 RESULTS: In late-stage cancer patients, plasma levels of multiple biomarkers, including IL6, G-CSF, MCP-1, and MIP1-beta, increased with increasing motolimod dose. VTX-2337 148-157 interleukin 6 Homo sapiens 88-91 26677330-11 2015 CONCLUSION: These results demonstrate that serum levels of interleukin-6, interleukin-8, and macrophage inflammatory protein-1beta as potential blood biomarkers could be utilized to identify the responsiveness of patients to serotonin and norepinephrine reuptake inhibitor like milnacipran, or to identify those patients who may experience AEs strong enough to warrant discontinuation of treatment. Milnacipran 278-289 interleukin 6 Homo sapiens 59-72 26445021-9 2015 At variance, osteoblast production of alkaline phosphatase and type I pro-collagen were promoted by the presence of bisphosphonate, which also decreased the production of interleukin 6. Diphosphonates 116-130 interleukin 6 Homo sapiens 171-184 26507164-8 2015 We found that icariin inhibited TNF-alpha/IFN-gamma-induced IL-6, IL-8, IL-1beta, and MCP-1 production in a dose-dependent manner; meanwhile, the icariin treatment inhibited the gene expression of IL-8, IL-1beta, ICAM-1 and TACR1 in HaCaT cells in a time- and dose-dependent manner. icariin 14-21 interleukin 6 Homo sapiens 60-64 26513016-0 2015 Lapatinib increases motility of triple-negative breast cancer cells by decreasing miRNA-7 and inducing Raf-1/MAPK-dependent interleukin-6. Lapatinib 0-9 interleukin 6 Homo sapiens 124-137 26513016-4 2015 In this study, we explored that the level of interleukin-6 (IL-6) was elevated in lapatinib-treated TNBC cells. Lapatinib 82-91 interleukin 6 Homo sapiens 45-58 26513016-4 2015 In this study, we explored that the level of interleukin-6 (IL-6) was elevated in lapatinib-treated TNBC cells. Lapatinib 82-91 interleukin 6 Homo sapiens 60-64 26513016-5 2015 Treatment with IL-6 antibody abolished the lapatinib-induced migration. Lapatinib 43-52 interleukin 6 Homo sapiens 15-19 26513016-6 2015 Mechanistically, the signaling axis of Raf-1/mitogen-activated protein kinases (MAPKs), c-Jun N-terminal kinases (JNKs), p38 MAPK, and activator protein 1 (AP-1) was activated in response to lapatinib treatment to induce IL-6 expression. Lapatinib 191-200 interleukin 6 Homo sapiens 221-225 26513016-8 2015 Our results not only revealed IL-6 as a key regulator of lapatinib-induced metastasis, but also explored the requirement of miR7/Raf-1/MAPK/AP-1 axis in lapatinib-induced IL-6 expression. Lapatinib 57-66 interleukin 6 Homo sapiens 30-34 26513016-8 2015 Our results not only revealed IL-6 as a key regulator of lapatinib-induced metastasis, but also explored the requirement of miR7/Raf-1/MAPK/AP-1 axis in lapatinib-induced IL-6 expression. Lapatinib 153-162 interleukin 6 Homo sapiens 171-175 26522776-8 2015 Transformed resistant cells were sensitive to chemical probe (sulforaphane) through inhibition of IL-6/STAT3/NF-kappaB positive feedback loop whereas parental HER2(+) cells did not respond. sulforaphane 62-74 interleukin 6 Homo sapiens 98-102 26216444-6 2015 N(1)-MeSpd diminished intracellular reactive oxygen species production in cultured keratinocytes, and reduced tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-6 gene and protein expression after lipopolysaccharide stimulation. 4-(2-(4-isopropylbenzamido)ethoxy)benzoic acid 0-4 interleukin 6 Homo sapiens 166-170 26602409-10 2015 An increasing serum IL- 6 level induced by the AZA therapy was later confirmed. Azacitidine 47-50 interleukin 6 Homo sapiens 20-25 28793632-7 2015 Cell cultures on plastic showed that PGA-alpha-MSH reduced EC and FB migration and decreased IL-6 and TGF-beta expression in Pg-LPS stimulated EC. pg-lps 125-131 interleukin 6 Homo sapiens 93-97 28793632-9 2015 A significant decrease of IL-6, TNF-alpha, and TGF-beta expression was also observed in Pg-LPS stimulated EC and FB. pg-lps 88-94 interleukin 6 Homo sapiens 26-30 26339979-6 2015 Our results showed that endotoxin nanovesicles with such dense lipid A units can elicit the stronger inflammatory gene expressions, including interleukin 6 (IL-6), IL-1A, TNF-alpha, C-X-C chemokine ligand (CXCL) 1, 2, and 11, which have characteristics of T-helper 1 adjuvants. Lipid A 63-70 interleukin 6 Homo sapiens 142-155 26339979-6 2015 Our results showed that endotoxin nanovesicles with such dense lipid A units can elicit the stronger inflammatory gene expressions, including interleukin 6 (IL-6), IL-1A, TNF-alpha, C-X-C chemokine ligand (CXCL) 1, 2, and 11, which have characteristics of T-helper 1 adjuvants. Lipid A 63-70 interleukin 6 Homo sapiens 157-161 26013040-8 2015 Ch/gamma-PGA PEMs with IFN-gamma were able to modulate the phenotype of IL-10-treated macrophages at the cell cytoskeleton and cytokine profile levels, inducing an increase of IL-6 and a decrease of IL-10 production. poly(gamma-glutamic acid) 3-12 interleukin 6 Homo sapiens 176-180 26202921-10 2015 MAIN RESULTS AND THE ROLE OF CHANCE: The long chain saturated fatty acids, stearic and palmitic (PA), stimulated the synthesis as well as the release of TNF-alpha, IL-6 and IL-8 by trophoblast cells (2- to 6-fold, P < 0.001). stearic 75-82 interleukin 6 Homo sapiens 164-168 26004392-11 2015 In vitro studies showed that both LXA4 (10 nmol/L) and BDNF (500 pg) decreased the IL-6 levels (p=0.036, 0.0002), in LPS induced pro-inflammatory condition in ARPE 19 cells, thereby their anti-inflammatory effect. lipoxin A4 34-38 interleukin 6 Homo sapiens 83-87 26292290-7 2015 MMP-3, IL-6, NO production and ADAMTS-4 expression were down-regulated in a concentration-dependent manner by carnosol (p<0.01). carnosol 110-118 interleukin 6 Homo sapiens 7-11 26292290-9 2015 IL-6 and PGE2 production was reduced in the presence of carnosol in both SC and NSC osteoblasts while alkaline phosphatase activity was not changed. carnosol 56-64 interleukin 6 Homo sapiens 0-4 26292290-12 2015 Inhibition of matrix degradation and enhancement of formation was observed in chondrocytes cocultured with subchondral osteoblasts preincubated with carnosol indicating a cross-talk between these two cellular compartments, potentially mediated via inhibition of IL-6 in osteoblasts as similar results were obtained with anti-IL-6 antibody. carnosol 149-157 interleukin 6 Homo sapiens 262-266 26292290-12 2015 Inhibition of matrix degradation and enhancement of formation was observed in chondrocytes cocultured with subchondral osteoblasts preincubated with carnosol indicating a cross-talk between these two cellular compartments, potentially mediated via inhibition of IL-6 in osteoblasts as similar results were obtained with anti-IL-6 antibody. carnosol 149-157 interleukin 6 Homo sapiens 325-329 26268945-11 2015 CONCLUSION: Our results suggest that paracrine IL-6 signaling between preinvasive DCIS cells and stromal CAFs represent an important factor in the initiation of DCIS progression to invasive breast carcinoma. cafs 105-109 interleukin 6 Homo sapiens 47-51 26278425-9 2015 RESULTS: Rosuvastatin lowered IL-6 levels at T4, T5 and T6 time points (T4, T5, T6 p < 0.05), and elevated IL-10 levels at T3 and T4 (T3, T4 p < 0.05). Rosuvastatin Calcium 9-21 interleukin 6 Homo sapiens 30-34 27828735-6 2017 Iohexol and Urografin also caused a significant increase in NF-kappaB followed by the release of IL-6 and MCP-1. Iohexol 0-7 interleukin 6 Homo sapiens 97-101 28465707-7 2017 The downmodulation of IL-6 by P. cicadae was inhibited by the p38 inhibitor (SB203580) or JNK inhibitor (SP600125). pyrazolanthrone 105-113 interleukin 6 Homo sapiens 22-26 27774655-7 2017 Propolis, Cin, Cou and Caf + Cin stimulated IL-6 production. coumarin 15-18 interleukin 6 Homo sapiens 44-48 27612769-3 2016 The results showed that DLC films with a low ratio of sp(2)/sp(3), which tend to have a structure similar to that of diamond, led to less inflammatory, excellent osteogenic and fibroblastic reactions, with higher cell viability, better morphology, lower release of TNF-alpha (tumor necrosis factor-alpha) and IL-6 (interleukin-6), and higher release of IL-10 (interleukin-10). sp(2) 54-59 interleukin 6 Homo sapiens 309-313 27612769-3 2016 The results showed that DLC films with a low ratio of sp(2)/sp(3), which tend to have a structure similar to that of diamond, led to less inflammatory, excellent osteogenic and fibroblastic reactions, with higher cell viability, better morphology, lower release of TNF-alpha (tumor necrosis factor-alpha) and IL-6 (interleukin-6), and higher release of IL-10 (interleukin-10). sp(2) 54-59 interleukin 6 Homo sapiens 315-328 27816506-2 2016 The active constituents of Rosa spp., such as flavonoids, triterpenoids, and phytosterols, could act on different targets in the NF-kappaB signalling pathway, inhibit pro-inflammatory enzymes (e.g. MMPs and COX-2), lower the production of inflammatory cytokines and chemokines (e.g. TNF-alpha, IL-1beta, IL-6, CCL5), and reduce oxidative stress, which in turn suppress inflammatory processes. Flavonoids 46-56 interleukin 6 Homo sapiens 304-308 27568842-6 2016 Visfatin treatment can increase the phosphorylation of both p65 and ERK1/2 in MG-63 and HOS cells, while only the inhibitor of NF-kappaB, BAY 11-7082, can abolish visfatin induced up regulation of IL-6. 3-(4-methylphenylsulfonyl)-2-propenenitrile 138-149 interleukin 6 Homo sapiens 197-201 27598863-6 2016 Expression of inflammatory genes, IL-1beta, IL-6, IL-8, IL-10 and TNF-alpha was found to be sequentially decreased when flavonoid concentration increased. Flavonoids 120-129 interleukin 6 Homo sapiens 44-48 26609631-7 2016 We further show that quercetin, a dietary compound having preventive properties for lung cancer, decreased BPDE-stimulated IL-6 secretion from human lung fibroblasts through inhibition of the NF-kappaB and ERK pathways. Quercetin 21-30 interleukin 6 Homo sapiens 123-127 26609631-9 2016 Finally, quercetin blocked IL-6-induced STAT3 activation in HBECs, and IL-6 enhancement of HBEC transformation by BPDE was abolished by quercetin treatment. Quercetin 9-18 interleukin 6 Homo sapiens 27-31 26609631-9 2016 Finally, quercetin blocked IL-6-induced STAT3 activation in HBECs, and IL-6 enhancement of HBEC transformation by BPDE was abolished by quercetin treatment. Quercetin 136-145 interleukin 6 Homo sapiens 27-31 26609631-9 2016 Finally, quercetin blocked IL-6-induced STAT3 activation in HBECs, and IL-6 enhancement of HBEC transformation by BPDE was abolished by quercetin treatment. Quercetin 136-145 interleukin 6 Homo sapiens 71-75 27782997-9 2016 After 2 hours, topical minocycline reduced concentrations of the inflammatory cytokines interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha (p < 0.01), and inflammatory cell counts in wound tissue (p < 0.05). Minocycline 23-34 interleukin 6 Homo sapiens 107-153 27782997-10 2016 In noninfected wounds, topical minocycline significantly reduced interleukin-1beta, interleukin-6, and inflammatory cell counts after 4 hours (p < 0.01). Minocycline 31-42 interleukin 6 Homo sapiens 84-97 27222933-7 2016 Alloreactive effector T cells that expanded in the absence of IL-6 were also more susceptible to Fas-mediated activation-induced cell death in vitro. ammonium ferrous sulfate 97-100 interleukin 6 Homo sapiens 62-66 27455900-6 2016 Results from enzyme linked immunosorbent assays revealed that 1,8-cineole suppressed LPS-induced secretion of interleukin-6 and interleukin-8, and recovered nitric oxide to normal levels. Eucalyptol 62-73 interleukin 6 Homo sapiens 110-123 26790758-5 2016 State anxiety as well as circulating interleukin (IL)-6, tumor necrosis factor (TNF)-alpha and IL-10 concentrations were significantly increased 2h and 3h after LPS administration, with a peak at 2h, and returned to baseline 6h after administration. Deuterium 145-147 interleukin 6 Homo sapiens 37-55 27271301-4 2016 After three weeks the E MTX + DOLE group maintained high catalase activity, exhibited decrease of lipid peroxidation and protein damage indicators-thiols and nitrites, while levels of DNA damage and pro-inflammatory interleukin-6 were significantly reduced. Methotrexate 24-27 interleukin 6 Homo sapiens 216-229 27271301-7 2016 Combined administration of DOLE with MTX contributes to faster reduction of cell damage, restores oxidative balance and improves interleukin-6 suppression during high disease activity in early phase RA, but not in long term patients. Methotrexate 37-40 interleukin 6 Homo sapiens 129-142 27392742-1 2016 The aim of this meta-analysis was to evaluate the efficacy of curcuminoids supplementation on circulating concentrations of IL-6 in randomized controlled trials (RCTs). curcuminoids 62-74 interleukin 6 Homo sapiens 124-128 27392742-2 2016 The search included PubMed-Medline, Scopus, Web of Science and Google Scholar databases by up to November 01, 2015, to identify RCTs investigating the impact of curcuminoids on circulating IL-6 concentrations. curcuminoids 161-173 interleukin 6 Homo sapiens 189-193 27392742-4 2016 There was a significant reduction of circulating IL-6 concentrations following curcuminoids supplementation (WMD: -0.60pg/mL, 95% CI: -1.06, -0.14, p=0.011). curcuminoids 79-91 interleukin 6 Homo sapiens 49-53 27484114-0 2016 Polydopamine Thin Films as Protein Linker Layer for Sensitive Detection of Interleukin-6 by Surface Plasmon Enhanced Fluorescence Spectroscopy. polydopamine 0-12 interleukin 6 Homo sapiens 75-88 27421015-7 2016 Quercetin suppressed the secretion of tumor necrosis factor-a, interleukin (IL)-1b, and IL-6 in LPS-stimulated human PBMCs. Quercetin 0-9 interleukin 6 Homo sapiens 88-92 27038916-6 2016 The amounts of proinflammatory cytokines produced by macrophages, such as interleukin 1 beta, interleukin 6, and tumor necrosis factor alpha, were reduced significantly for the quercetin-loaded silica nanoparticles. Quercetin 177-186 interleukin 6 Homo sapiens 94-107 27011369-6 2016 Unfractionated heparin as well as tinzaparin attenuated the IL-1beta-mediated induction of IL-6, IL-11, and LIF on protein and messenger RNA (mRNA) levels. Tinzaparin 34-44 interleukin 6 Homo sapiens 91-95 27376259-0 2016 Study of the UV Light Conversion of Feruloyl Amides from Portulaca oleracea and Their Inhibitory Effect on IL-6-Induced STAT3 Activation. feruloyl amides 36-51 interleukin 6 Homo sapiens 107-111 27351598-13 2016 Serum IL-6 and TNF may define an ASD subgroup that benefits most from treatment with the natural flavonoid luteolin. Flavonoids 97-106 interleukin 6 Homo sapiens 6-10 27180822-1 2016 In this work, we first exposed that the application of p-type semiconductor, silver iodide-chitosan nanoparticle (SICNP), acted as peroxidase mimetic to catalyze the bioprecipitation reaction for signal-amplification photocathodic immunosensing of human interleukin-6 (IL-6). silver iodide-chitosan 77-99 interleukin 6 Homo sapiens 254-267 27180822-1 2016 In this work, we first exposed that the application of p-type semiconductor, silver iodide-chitosan nanoparticle (SICNP), acted as peroxidase mimetic to catalyze the bioprecipitation reaction for signal-amplification photocathodic immunosensing of human interleukin-6 (IL-6). silver iodide-chitosan 77-99 interleukin 6 Homo sapiens 269-273 27076371-4 2016 Peak levels of 24 cytokines, including IFNgamma, IL6, sgp130, and sIL6R, in the first month after infusion were highly associated with severe CRS. 3-cresol 142-145 interleukin 6 Homo sapiens 49-52 26244291-6 2015 Sorafenib significantly inhibited production of TGF-beta1, VEGF, IL-6, IL-8, MCP-1, and TNF-alpha and blocked the activation of migration-related signaling molecules, such as HIF-1alpha, p-STAT3, MMP2, and Ang-1. Sorafenib 0-9 interleukin 6 Homo sapiens 65-69 27075589-6 2016 Compared to the untreated group, production of IL-6 was significantly decreased in the chitosan MPs-treated group, but chitin MPs treatment cause elevation of IL-6 level. Chitin 119-125 interleukin 6 Homo sapiens 159-163 2583859-9 1989 Thus, TAM exhibit a dissociation in their capacity to release the functionally related monokines IL-1 and IL-6. tam 6-9 interleukin 6 Homo sapiens 106-110 2583859-10 1989 IL-6 produced by TAM may account for the elevation of liver-derived acute-phase proteins associated with malignancy. tam 17-20 interleukin 6 Homo sapiens 0-4 2788520-4 1989 LPS, lipid A, and TNF increased IL6 release modestly (5 to 20-fold), while recombinant IL1s (rIL1s) stimulated this process 100 to 400-fold. Lipid A 5-12 interleukin 6 Homo sapiens 32-35 26812074-9 2016 Consistently, the oligoribonucleotide mimics and an oligodeoxynucleotide decoy of lnc-DILC abrogated the effects on IL-6 transcription, STAT3 activation and LCSC expansion triggered by lnc-DILC depletion and lnc-DILC overexpression. Oligoribonucleotides 18-37 interleukin 6 Homo sapiens 116-120 2842790-6 1988 TNF, IL-1, and forskolin all stimulated interleukin 6 (IL-6) mRNA levels in FS-4 cells. Colforsin 15-24 interleukin 6 Homo sapiens 40-53 27417728-1 2016 The level of TNFalpha and IL6 in the blood plasma of patients with rheumatoid arthritis (RA) who received antiinflammatory therapy with methotrexate (MT) was significantly lower than in the patients without MT treatment. Methotrexate 136-148 interleukin 6 Homo sapiens 26-29 27044888-6 2016 Finally, the frequency of Synergistetes, positively correlated with the Firmicutes/Bacteroidetes ratio in healthy controls, tended to be reduced in patients when anti-dsDNA titers were increased and showed a strong negative correlation with IL-6 serum levels and correlated positively with protective natural IgM antibodies against phosphorylcholine. Phosphorylcholine 332-349 interleukin 6 Homo sapiens 241-245 2842790-6 1988 TNF, IL-1, and forskolin all stimulated interleukin 6 (IL-6) mRNA levels in FS-4 cells. Colforsin 15-24 interleukin 6 Homo sapiens 55-59 2842790-7 1988 The protein kinase inhibitor H-8, inhibiting preferentially cAMP-dependent kinase activity, reduced forskolin-stimulated IL-6 mRNA induction more strongly than TNF- or IL-1-driven IL-6 mRNA induction. Colforsin 100-109 interleukin 6 Homo sapiens 121-125 26593599-4 2016 Our data demonstrated that LCB significantly reduced the expression and secretion of IL-6, MCP-1 and leptin, as well as suppressed the overexpression of PAI-1 induced by H2O2. CHEMBL4090226 27-30 interleukin 6 Homo sapiens 85-89 4084549-5 1985 Of special interest, tyrosine A, phenylalanine A, tryptophan B1, and tryptophan B2 were found to be located close to a cluster of aliphatic residues, indicating that the hydrophobic site of the HSF is conformationally rigid and its tertiary structure very compact. tryptophan b1 50-63 interleukin 6 Homo sapiens 194-197 34058440-9 2021 Both 3alpha and 3beta-OH tibolone seemed to bind better to IL6 at important sites responsible for its binding to IL6R. 3alpha and 3beta-oh tibolone 5-33 interleukin 6 Homo sapiens 59-62 27135904-7 2016 Oral lansoprazole therapy decreased the frequency of acute exacerbation of COPD by alleviating gastroesophageal reflux and lowering the levels of IL-1beta, IL-6, IL-8, TNF-alpha and GM-CSF in the sputum. Lansoprazole 5-17 interleukin 6 Homo sapiens 156-160 34021857-7 2021 RESULTS: Enzyme-linked immunosorbent assay (ELISA) demonstrated that IL-1beta, IL-6, and TNF-alpha upregulated by lipopolysaccharide (LPS) was decreased by treatment with GB. glabridin 171-173 interleukin 6 Homo sapiens 79-83 26718265-4 2016 TBBPA exposure significantly increased the expression of ICAM-1 and IL-6, but not IL-8. tetrabromobisphenol A 0-5 interleukin 6 Homo sapiens 68-72 26718265-9 2016 TBBPA but not HBCD showed ligand activity for thyroid hormone receptor (TR) and TR antagonist significantly suppressed the TBBPA-induced increase of the expression of ICAM-1 and IL-6. tetrabromobisphenol A 0-5 interleukin 6 Homo sapiens 178-182 26718265-9 2016 TBBPA but not HBCD showed ligand activity for thyroid hormone receptor (TR) and TR antagonist significantly suppressed the TBBPA-induced increase of the expression of ICAM-1 and IL-6. tetrabromobisphenol A 123-128 interleukin 6 Homo sapiens 178-182 33958640-0 2021 Interplay between IL6 and CRIM1 in thiopurine intolerance due to hematological toxicity in leukemic patients with wild-type NUDT15 and TPMT. 2-mercaptopyrazine 35-45 interleukin 6 Homo sapiens 18-21 33958640-8 2021 Interplay between IL6 rs13306435 and CRIM1 rs3821169 was suggested as an independent and/or additive genetic determinant of thiopurine intolerance beyond NUDT15 and TPMT in pediatric ALL. 2-mercaptopyrazine 124-134 interleukin 6 Homo sapiens 18-21 27019421-14 2016 Minocycline modified the relationship between urine IL-6 and proteinuria, suggesting a protective biological effect. Minocycline 0-11 interleukin 6 Homo sapiens 52-56 33913752-0 2021 The Effect of Rosuvastatin on plasma/serum levels of high sensitivity C-reactive protein, Interleukin-6 and D-dimer in people living with Human Immunodeficiency Virus: a systematic review and meta-analysis. Rosuvastatin Calcium 14-26 interleukin 6 Homo sapiens 90-103 27012679-10 2016 Consistent with its effect on JAK2/STAT3 suppression, honokiol also markedly inhibited IL-6-mediated migration of SAS cells. honokiol 54-62 interleukin 6 Homo sapiens 87-91 33962830-9 2022 RESULTS: Hemin improved burn-induced renal histological damage and dysfunction, and this beneficial effect was related to reduced renal oxidative stress and the release of proinflammatory mediators, such as tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-6 and intracellular adhesion molecule-1 (ICAM-1). Hemin 9-14 interleukin 6 Homo sapiens 272-276 26900950-5 2016 Therefore, our results provide new insights into the mechanisms by which CAFs induce tumor immune escape as well as a novel cancer immunotherapeutic approach (for example, targeting CAFs, IDO or IL-6). cafs 73-77 interleukin 6 Homo sapiens 195-199 33921615-12 2021 In addition, lipoxin A4 inhibited the infiltration of neutrophils and the production of cytokines and pro-inflammatory chemokines, such as interleukin (Il-1beta, Il-6, Il-8) and tumor necrosis factor-alpha (TNF-alpha). lipoxin A4 13-23 interleukin 6 Homo sapiens 162-166 26751065-8 2016 In CKD 3-5, TMAO levels were associated with IL-6 (Rho = 0.42; p<0.0001), fibrinogen (Rho = 0.43; p<0.0001) and hsCRP (Rho = 0.17; p = 0.022). trimethyloxamine 12-16 interleukin 6 Homo sapiens 45-49 33849528-9 2021 Additionally, the results clarified that ICA significantly inhibited the migration, invasion capacity, and expression levels of TGF-beta1, TNF-alpha, IL-6, IL-17A, IL-10 in SiHa cells. icariin 41-44 interleukin 6 Homo sapiens 150-154 27294162-7 2016 The placental extravillous layer of the MGH showed high levels of IL-4, IL-6, IL-10, IL-17, and IFN-gamma and low levels of IL-1beta and IL-8, whereas the placental villous layer contained high levels of IL-17 and IFN-gamma. mgh 40-43 interleukin 6 Homo sapiens 72-76 33916909-7 2021 We then loaded PLGA nanoparticles with oxyresveratrol and we observed that oxyresveratrol-bearing particles did not stimulate the cytokine release by resting DCs and inhibited the PLGA-dependent enhancement of IL-12, IL-6, and TNF-alpha secretion by R848-stimulated DCs. puag-haad 75-89 interleukin 6 Homo sapiens 217-221 28116315-7 2016 The effects of SP600125, an inhibitor of the JNK pathway, on the increase of p-JNK, IL-6, and IL-8 were also studied. pyrazolanthrone 15-23 interleukin 6 Homo sapiens 84-88 28116315-11 2016 Furthermore, SP600125 significantly inhibited the activation of JNK signal, as well as reducing the productions of IL-6 and IL-8 in response to PLA+LPS stimulation. pyrazolanthrone 13-21 interleukin 6 Homo sapiens 115-119 34004418-7 2021 RESULTS: In this study, 4 wk of sulforaphane intake decreased plasma levels of creatine kinase, especially creatine kinase levels from 30 min to 24 h and baseline to 24 h. Moreover, the change in interleukin-6 levels significantly decreased from baseline to 30 min on prolonged intake of sulforaphane. sulforaphane 32-44 interleukin 6 Homo sapiens 196-209 26481476-8 2016 Specifically, SA significantly increased the expression of Ccl5 (5.3-fold) and Mcp-1 (3.2-fold), and the secretion of IL-6 (17.8-fold) and MCP-1 (4.0-fold) in SCD1-inhibited adipocytes compared to controls. Stearates 14-16 interleukin 6 Homo sapiens 118-122 34004418-7 2021 RESULTS: In this study, 4 wk of sulforaphane intake decreased plasma levels of creatine kinase, especially creatine kinase levels from 30 min to 24 h and baseline to 24 h. Moreover, the change in interleukin-6 levels significantly decreased from baseline to 30 min on prolonged intake of sulforaphane. sulforaphane 288-300 interleukin 6 Homo sapiens 196-209 33559343-6 2021 FINDINGS: Serum levels of IL-6 and TNF-alpha were similar in the two groups at baseline but were lower after 12 weeks of treatment with nanocurcumin compared to placebo (P = 0.024 for IL-6 and 0.02 for TNF). nanocurcumin 136-148 interleukin 6 Homo sapiens 26-30 26528857-8 2015 In line with the above findings, treatment with either IL-3 or IL-6 or IL-11 decreased the chemosensitivity to docetaxel while treatment with either IL-10 or IL-24 increased the sensitivity of docetaxel chemotherapy. Docetaxel 111-120 interleukin 6 Homo sapiens 63-67 26485683-10 2015 Albumin-overload induced TNF-alpha and IL-6 secretions by the TLR2-MyD88-NF-kappaB pathway activation, which could be attenuated by the TLR2 siRNA or BAY 11-7082 in HK-2 cells. 3-(4-methylphenylsulfonyl)-2-propenenitrile 150-161 interleukin 6 Homo sapiens 39-43 33559343-6 2021 FINDINGS: Serum levels of IL-6 and TNF-alpha were similar in the two groups at baseline but were lower after 12 weeks of treatment with nanocurcumin compared to placebo (P = 0.024 for IL-6 and 0.02 for TNF). nanocurcumin 136-148 interleukin 6 Homo sapiens 184-188 33715142-4 2021 CONCLUSION: PPGL combined with persistent elevated inflammatory markers, either in the presence or absence of pyrexia, raised suspicion of IL-6 overproduction in these three patients. ppgl 12-16 interleukin 6 Homo sapiens 139-143 26319615-3 2015 OBJECTIVES: To evaluate the effects of vitamin D (25(OH)D3 and 1,25(OH)2D3) on the secretion of inflammatory cytokines (TNF-alpha and IL-6) in omental (OM) and SC human AT and to explore factors that could correlate with the individual response to vitamin D including age, smoking status, BMI, comorbidities, medication, HbA1c, apolipoprotein B, serum 25-hydroxyvitamin D and high sensitivity C-reactive protein. Deuterium 47-48 interleukin 6 Homo sapiens 134-138 26610473-6 2015 TNF-alpha, IL-1beta, IL-6 were modulated to HepG2 cells by treatment of Gardenoside. gardenoside 72-83 interleukin 6 Homo sapiens 21-25 33594879-5 2021 The MSCs on the PDA-coated substrate showed a lower level of interleukin 6 (IL-6), one of the senescence-associated inflammatory components. polydopamine 16-19 interleukin 6 Homo sapiens 61-74 26473447-0 2015 The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression. vistusertib 45-52 interleukin 6 Homo sapiens 129-132 33594879-5 2021 The MSCs on the PDA-coated substrate showed a lower level of interleukin 6 (IL-6), one of the senescence-associated inflammatory components. polydopamine 16-19 interleukin 6 Homo sapiens 76-80 33652665-4 2021 Subsequently, their effects with methyldopa on the expression of selected markers responsible for inflammation (TNF-alpha; IL-1beta; IL-6) and vascular effects (hypoxia-inducible factor 1alpha-HIF-1alpha; placental growth factor-PIGF; transforming growth factor beta-TGF-beta; vascular endothelial growth factor-VEGF) at the mRNA and protein levels were assessed. Methyldopa 33-43 interleukin 6 Homo sapiens 133-137 26202107-5 2015 Depot medroxyprogesterone acetate (DMPA) users had significantly higher MIP-1alpha, MIP-1beta, IL-6, IL-8, IP-10, and RANTES concentrations. Medroxyprogesterone Acetate 6-33 interleukin 6 Homo sapiens 95-99 26202107-5 2015 Depot medroxyprogesterone acetate (DMPA) users had significantly higher MIP-1alpha, MIP-1beta, IL-6, IL-8, IP-10, and RANTES concentrations. Medroxyprogesterone Acetate 35-39 interleukin 6 Homo sapiens 95-99 33669254-10 2021 Changes in IL-6 indirectly mediated depression outcome, with metyrapone increasing IL-6 levels and IL-6 increase associated with a poorer outcome on depression. Metyrapone 61-71 interleukin 6 Homo sapiens 11-15 26095743-9 2015 RESULTS: IL-6 was significantly decreased in the ETN+MTX and IFX+MTX groups, although not in the ETN-only group; this change was consistent with changes in disease activity. Methotrexate 53-56 interleukin 6 Homo sapiens 9-13 26095743-9 2015 RESULTS: IL-6 was significantly decreased in the ETN+MTX and IFX+MTX groups, although not in the ETN-only group; this change was consistent with changes in disease activity. Methotrexate 65-68 interleukin 6 Homo sapiens 9-13 26193267-9 2015 Our data reveals that interferon-beta therapy improves the immunoregulation of autoaggressive T effector cells in MS patients by changing the IL-6 signal transduction pathway, thus restoring their sensitivity to Treg-mediated suppression. treg 212-216 interleukin 6 Homo sapiens 142-146 33669254-10 2021 Changes in IL-6 indirectly mediated depression outcome, with metyrapone increasing IL-6 levels and IL-6 increase associated with a poorer outcome on depression. Metyrapone 61-71 interleukin 6 Homo sapiens 83-87 33669254-10 2021 Changes in IL-6 indirectly mediated depression outcome, with metyrapone increasing IL-6 levels and IL-6 increase associated with a poorer outcome on depression. Metyrapone 61-71 interleukin 6 Homo sapiens 83-87 33578542-6 2021 After treatment, the serum IL-6 level of patients in the resistance group was 17.21 +- 0.98 ng/L, which was significant higher than that of patients in the sensitive group (11.21 +- 0.68 ng/L), and the difference was statistically significant (P < .05).Patients with cerebral infarction in Guizhou region have a higher occurrence rate of clopidogrel resistance. Clopidogrel 338-349 interleukin 6 Homo sapiens 27-31 25682882-7 2015 Formulations of TMX-202 in cationic liposomes were potent in targeting and activation of monocytes, with strong induction of IL-6 and IL-12p40, and differentiation into CD14(+) and DC-SIGN+ DCs. TMX-202 16-23 interleukin 6 Homo sapiens 125-129 26209236-8 2015 These changes were accompanied by an attenuation of BLM-induced elevations in pulmonary levels of profibrotic cytokines interleukin-6, monocyte chemoattractant protein-1, and transforming growth factor-beta (TGF-beta). Bleomycin 52-55 interleukin 6 Homo sapiens 120-133 33539038-12 2021 According to the cytokine antibody array results, hOBs pretreated with AZA had significantly increased production of several inflammatory cytokines (P<0.05), in which the expression levels of IL-6 and IL-8 were the most dramatically increased upon LTA stimulation (P<0.01). lipoteichoic acid 248-251 interleukin 6 Homo sapiens 192-196 26352938-7 2015 Furthermore, a significant correlation was observed between the levels of IL-6 immediately post-exercise and free fatty acids 2 h post-exercise in the evening (r = 0.68, P < 0.01). Fatty Acids, Nonesterified 109-125 interleukin 6 Homo sapiens 74-78 26352938-9 2015 In addition, IL-6 was involved in increasing free fatty acids, suggesting that the evening is more effective for exercise-induced lipolysis compared with the morning. Fatty Acids, Nonesterified 45-61 interleukin 6 Homo sapiens 13-17 26073057-8 2015 Furthermore, TRF from MGSO markedly reduced LPS-induced proinflammatory gene expression in human adipocytes and cytokine secretion to the medium (IL-6 and IL-8). mgso 22-26 interleukin 6 Homo sapiens 146-150 33044583-11 2021 However, both the 1.8 cineole treatment and alpha-pinene treatments significantly decreased TNF-alpha, IL-1beta, IL-6, and eNOS mRNA expression induced by LPS. Eucalyptol 22-29 interleukin 6 Homo sapiens 113-117 25545021-6 2015 Inhibition of KCa3.1 by the selective, pore-blocking inhibitor TRAM-34, (and, in part, by siRNA) significantly reduced cell proliferation, as well as expression and secretion of pro-inflammatory factors (IL-6, IL-8, and MCP1) and the tissue-destructive protease MMP3. TRAM 34 63-70 interleukin 6 Homo sapiens 204-208 26468028-4 2015 The reference drug quercetin dihydrate induced an insignificant change in the level of IL-2 and IL-6 and small increase in IFN-gamma content. Quercetin 19-38 interleukin 6 Homo sapiens 96-100 26049028-7 2015 Supernatant IL-1beta and IL-6 levels were significantly lower in the PF group compared with ATP group (p<0.001, p<0.001). peoniflorin 69-71 interleukin 6 Homo sapiens 25-29 26049028-8 2015 We show for the first time that PF-mediated reduction of IL-1beta and IL-6 was due in part to the reduced expression and activation of the ATP sensor P2X7R on pSS PBMCs, indicating that PF might be useful for the management of pSS via down-regulating P2X7R expression. peoniflorin 32-34 interleukin 6 Homo sapiens 70-74 25765005-8 2015 IL-6-mediated inhibition of NTCP-mediated taurocholate uptake and viral entry exhibited similar dose-dependence and kinetics while restoration of NTCP expression suppressed the inhibitory effect of IL-6. Taurocholic Acid 42-54 interleukin 6 Homo sapiens 0-4 33613982-5 2021 In addition, pro-inflammatory cytokine expressions of TNF-alpha and IL-6 induced by the binary mixture of Phe and Flu were all alleviated by co-treatment with PI3K/AKT and NF-kappaB specific inhibitors (LY294002 and BAY11-7082). fluorene 114-117 interleukin 6 Homo sapiens 68-72 33613982-5 2021 In addition, pro-inflammatory cytokine expressions of TNF-alpha and IL-6 induced by the binary mixture of Phe and Flu were all alleviated by co-treatment with PI3K/AKT and NF-kappaB specific inhibitors (LY294002 and BAY11-7082). 3-(4-methylphenylsulfonyl)-2-propenenitrile 216-226 interleukin 6 Homo sapiens 68-72 26473157-6 2015 Treatment of HCT116 cells with withaferin-A attenuated interleukin-6-induced activation of STAT3, which has been implicated in the development and progression of colon cancer. withaferin A 31-43 interleukin 6 Homo sapiens 55-68 33481255-12 2021 r-hirudin and DTIP inhibit tumor progression through the thrombin-PAR-1-mediated RhoA and NF-kappaB signaling cascades via inhibiting the MMP9 and IL6 expression. dtip 14-18 interleukin 6 Homo sapiens 147-150 26690867-0 2015 Doxorubicin-Hyaluronan Conjugated Super-Paramagnetic Iron Oxide Nanoparticles (DOX-HA-SPION) Enhanced Cytoplasmic Uptake of Doxorubicin and Modulated Apoptosis, IL-6 Release and NF-kappaB Activity in Human MDA-MB-231 Breast Cancer Cells. ferric oxide 53-63 interleukin 6 Homo sapiens 161-165 25970160-13 2015 Niclosamide has the potential to target the IL6-Stat3-AR pathway to overcome enzalutamide resistance and inhibit migration and invasion in advanced prostate cancer. Niclosamide 0-11 interleukin 6 Homo sapiens 44-47 26170842-7 2015 The natural logs of hs-CRP and IL-6 levels in the TCFA group were higher than those in the non-TCFA group (hs-CRP 0.87 (-0.96 to 0.87) vs. -0.47 (-0.92 to 0.30) mg/l, p = 0.027; and IL-6 1.63 (0.63-3.23) vs. 0.53 (-0.21 to 1.05) pg/dl, p = 0.005, respectively). tcfa 50-54 interleukin 6 Homo sapiens 31-35 26170842-7 2015 The natural logs of hs-CRP and IL-6 levels in the TCFA group were higher than those in the non-TCFA group (hs-CRP 0.87 (-0.96 to 0.87) vs. -0.47 (-0.92 to 0.30) mg/l, p = 0.027; and IL-6 1.63 (0.63-3.23) vs. 0.53 (-0.21 to 1.05) pg/dl, p = 0.005, respectively). tcfa 50-54 interleukin 6 Homo sapiens 182-186 26170842-8 2015 In multivariate logistic regression analysis, log IL-6 was an independent predictor for TCFA detected by OCT (log IL-6, 0.970 pg/dl, p = 0.023). tcfa 88-92 interleukin 6 Homo sapiens 50-54 26170842-8 2015 In multivariate logistic regression analysis, log IL-6 was an independent predictor for TCFA detected by OCT (log IL-6, 0.970 pg/dl, p = 0.023). tcfa 88-92 interleukin 6 Homo sapiens 114-118 26170842-9 2015 Receiver operating characteristic curve analysis confirmed that IL-6, compared to hs-CRP, has a higher area under the curve for predicting TCFA (0.783 vs. 0.715, respectively). tcfa 139-143 interleukin 6 Homo sapiens 64-68 26170842-11 2015 Moreover, IL-6 has a higher potential than hs-CRP for predicting TCFA. tcfa 65-69 interleukin 6 Homo sapiens 10-14 33474710-9 2021 Together, these results suggested that MC-LR-mediated interaction between HiBECs and macrophages induced the M2-type polarization of macrophages, and activated IL-6/JAK2/STAT3, MEK/ERK, and PI3K/AKT pathways in HiBECs, further enhanced cell proliferation, improved cell migration, and hindered cell apoptosis by activating p-STAT3. mc-lr 39-44 interleukin 6 Homo sapiens 160-164 25777483-10 2015 Treatment with astaxanthin or withaferin A significantly reduced the increased levels of interleukin-1alpha, interleukin-6/8, granulocyte macrophage stimulatory factor and endothelin-1. withaferin A 30-42 interleukin 6 Homo sapiens 109-124 26345937-7 2015 This inhibition was concentration-dependent between 0.3 and 3 muM, with 3 muM concentration of midazolam decreasing the IL-1beta-induced release of IL-6 by 43.58%. Midazolam 95-104 interleukin 6 Homo sapiens 148-152 33657989-0 2021 Quercetin Induces Apoptosis in Glioblastoma Cells by Suppressing Axl/IL-6/STAT3 Signaling Pathway. Quercetin 0-9 interleukin 6 Homo sapiens 69-73 26283889-7 2015 CONCLUSIONS: Our study suggests that the increased number of blood monocytes might play key roles during the development of severe PAS, which enhance adhesion at the local narrowed peripheral artery and secret high levels of VEGF-C and IL-6. Aminosalicylic Acid 131-134 interleukin 6 Homo sapiens 236-240 26283889-8 2015 We suggest that serum concentrations of VEGF-C and IL-6 might be used as biomarkers for diagnosis severe PAS in combination with clinical imaging examination. Aminosalicylic Acid 105-108 interleukin 6 Homo sapiens 51-55 25856214-10 2015 16alpha-OH-E1 concentrations were positively correlated with body mass index, percentage fat mass, and IL-6 concentrations (P < .001). 16-hydroxyestrone 0-13 interleukin 6 Homo sapiens 103-107 33657989-8 2021 Quercetin also decreased IL-6 release and phosphorylation of STAT3 in GBM cells. Quercetin 0-9 interleukin 6 Homo sapiens 25-29 33657989-11 2021 In conclusion, we suggest quercetin as a potential anticancer agent, which may improve cancer microenvironment of GBM via the Axl/IL-6/STAT3 pathway. Quercetin 26-35 interleukin 6 Homo sapiens 130-134 32705933-3 2021 Indeed, EHC induced a lifelong systemic antibody response to immunization, in addition to reduced hypothalamic IL6 inflammatory expression following LPS challenge. ehc 8-11 interleukin 6 Homo sapiens 111-114 25849219-5 2015 Delivering 12-base-long pyrrolidinyl peptide nucleic acids with d-prolyl-(1S,2S)-2-aminocyclopentanecarboxylic acid backbone (acpcPNA) complementary to the antisense strand of the NF-kappaB binding site in the promoter region of the Il6 gene into the macrophage cell line, RAW 264.7, by our particles resulted in an obvious accumulation of the acpcPNAs in the nucleus and decreased Il6 mRNA and IL-6 protein levels upon stimulation. d-prolyl-(1s,2s)-2-aminocyclopentanecarboxylic acid 64-115 interleukin 6 Homo sapiens 233-236 25495178-7 2015 Rosuvastatin therapy was associated with a reduction in hsCRP (-20% vs. 11%, P = 0.017) and an attenuation of the rise in IL6 concentration (8% vs. 30%, P = 0.028) compared with placebo. Rosuvastatin Calcium 0-12 interleukin 6 Homo sapiens 122-125 33601383-8 2021 13-cis-retinoic acid and all-trans-retinoic acid regulated IL-6 release. Isotretinoin 0-20 interleukin 6 Homo sapiens 59-63 26053120-11 2015 In addition, treatment with PapMA and PapMA-k decreased the level of ultraviolet irradiation-induced expression of genes encoding matrix metalloproteinase-1 (MMP-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in human keratinocyte HaCaT cells. papma 28-33 interleukin 6 Homo sapiens 166-179 26053120-11 2015 In addition, treatment with PapMA and PapMA-k decreased the level of ultraviolet irradiation-induced expression of genes encoding matrix metalloproteinase-1 (MMP-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in human keratinocyte HaCaT cells. papma 28-33 interleukin 6 Homo sapiens 181-185 25791477-5 2015 Here, we show that BZ dramatically increases the IL-8 expression in lipopolysaccharide (LPS)-stimulated U937 macrophages as well as in unstimulated U937 monocytes and peripheral blood mononuclear cells, while it inhibits expression of IL-6, IL-1 and tumor necrosis factor-alpha. Bortezomib 19-21 interleukin 6 Homo sapiens 235-239 25708600-6 2015 RESULTS: Niclosamide reduced the secretion of IL-1beta, IL-6, IL-8, IL-17A and IFN-gamma from TNF-alpha-induced RA FLS in a dose-dependent manner. Niclosamide 9-20 interleukin 6 Homo sapiens 56-60 33092789-7 2020 Our study presents a novel mechanism of TAM-induced breast cancer metastasis via the IL-6-PRMT1-meR342-EZH2 axis. tam 40-43 interleukin 6 Homo sapiens 85-89 26132391-4 2015 Exposure of ciPTEC to cationic uremic toxins initiated production of the inflammatory cytokines IL-6 (117 +- 3%, p < 0.001), IL-8 (122 +- 3%, p < 0.001), and ET-1 (134 +- 5%, p < 0.001). ciptec 12-18 interleukin 6 Homo sapiens 96-100 33363471-6 2020 Results: At a clinically relevant concentration (1 nM), roflumilast N-oxide and roflumilast consistently reduced the release of TNF-alpha, CCL2, CCL3, CCL4, CCL5 and CXCL9 (but not CXCL1, CXCL5, CXCL8 and IL-6) from human bronchial explants. n-oxide 68-75 interleukin 6 Homo sapiens 205-209 26309657-3 2015 The aim of present study was to investigate the relationship between RSA and polymorphisms of cytokine genes coding for TNF-alpha (-308 G A, -238 G A), TNF-beta (+252 G A) as Th1 or pro-inflammatory factors as well as IL-6 (-634 G C, -174 G C), IL-10 (-1082 A G, -819 C T, -592C A) as Th2 cytokines in women with RSA compared with healthy women. rabbit sperm membrane autoantigen 69-72 interleukin 6 Homo sapiens 218-222 25655379-1 2015 Siltuximab, a chimeric monoclonal antibody with high affinity and specificity for interleukin-6, has been shown to enhance anti-multiple myeloma activity of bortezomib and corticosteroid in vitro. Bortezomib 157-167 interleukin 6 Homo sapiens 82-95 32679620-3 2020 Antigen attached Biotin-PA nanofibers trigger splenocytes to produce high levels of cytokines (IFN-gamma, IL-12, TNF-alpha, and IL-6) and to exhibit a superior cross-presentation of the antigen. biotin-pa 17-26 interleukin 6 Homo sapiens 128-132 25499119-4 2015 The level of SuPAR has been measured in PJI patients and healthy controls, correlated with canonical inflammatory markers, such as C-reactive protein, IL-6, IL-1 and TNFalpha and the chemokine CCL2. supar 13-18 interleukin 6 Homo sapiens 151-155 25499119-5 2015 Serum suPAR displayed a strongly significative increase in PJI patients compared to not infected controls, and a significative positive correlation with C-reactive protein, IL-6, IL-1 and TNFalpha and the chemokine CCL2. supar 6-11 interleukin 6 Homo sapiens 173-177 25771851-9 2015 Levels of inflammatory measures, TNF-alpha, IL-6 and ICAM-1 decreased significantly (p < 0.01) after treatment with rosuvastatin. Rosuvastatin Calcium 119-131 interleukin 6 Homo sapiens 44-48 25771851-12 2015 Significant negative correlation was observed between FMD and IL-6, ICAM-1, CRP after treatment with rosuvastatin. Rosuvastatin Calcium 101-113 interleukin 6 Homo sapiens 62-66 25771851-14 2015 Rosuvastatin lowers the proinflammatory cytokines, especially IL-6 and TNF-alpha, which downregulates adhesion molecules and CRP production which in turns improves ED. Rosuvastatin Calcium 0-12 interleukin 6 Homo sapiens 62-66 33174044-0 2020 Narasin inhibits tumor metastasis and growth of ERalpha-positive breast cancer cells by inactivation of the TGF-beta/SMAD3 and IL-6/STAT3 signaling pathways. narasin 0-7 interleukin 6 Homo sapiens 127-131 25836052-4 2015 The in vitro bioactivity of VX-745 was also shown on synoviocytes, reducing the IL-6 concentration. VX-745 28-34 interleukin 6 Homo sapiens 80-84 25961885-0 2015 In-vitro suppression of IL-6 and IL-8 release from human pulmonary epithelial cells by non-anticoagulant fraction of enoxaparin. Enoxaparin 117-127 interleukin 6 Homo sapiens 24-28 25961885-3 2015 Our study indicated that enoxaparin inhibits the release of IL-6 and IL-8 from A549 pulmonary epithelial cells. Enoxaparin 25-35 interleukin 6 Homo sapiens 60-64 25593198-4 2015 However, deprivation of IL-6 using a neutralizing antibody abrogated the ability of Loxoribin-treated DCs, which reversed the Treg cell-mediated suppression. loxoribin 84-93 interleukin 6 Homo sapiens 24-28 25961885-13 2015 RESULTS: Enoxaparin (60 mug/mL) inhibited the release of IL-6 and IL-8 by >30%. Enoxaparin 9-19 interleukin 6 Homo sapiens 57-61 33206688-7 2020 The in vitro study of EGYVIR extract against SARS-CoV-2 on Huh-7 cell lines, revealed the potential role of NF-kbeta/TNFalpha/IL-6 during the infection process. egyvir 22-28 interleukin 6 Homo sapiens 126-130 25557539-4 2015 In this study, it was demonstrated that IC stimulation of B cells not only suppresses CpG-oligodeoxynucleotide (CpG-ODN)-induced pro-inflammatory IL-6 and IgM kappa production, but also attenuates CD40 and CD80 expression. CPG-oligonucleotide 112-119 interleukin 6 Homo sapiens 146-150 25876656-4 2015 Myotubes treated with 1alpha,25(OH)2D3 increased interleukin-6 (IL-6) expression and inhibited expression of tumor necrosis factor alpha (TNF-alpha), whereas the expression of insulin-like growth factor-1 (IGF-1) that is involved in muscle hypertrophy was not affected. 1alpha 22-28 interleukin 6 Homo sapiens 49-62 25876656-4 2015 Myotubes treated with 1alpha,25(OH)2D3 increased interleukin-6 (IL-6) expression and inhibited expression of tumor necrosis factor alpha (TNF-alpha), whereas the expression of insulin-like growth factor-1 (IGF-1) that is involved in muscle hypertrophy was not affected. 1alpha 22-28 interleukin 6 Homo sapiens 64-68 32698696-4 2020 It was reported that the herbal extract at a Panax ginseng extract to Gastrodia elata extract ratio of 1:10 (w/w) and the compound mixture with equal proportion of ginsenoside F2 and alpha-gastrodin exhibited significant inhibition of MMP-1 and IL-6 production, and marked upregulation of procollagen type 1 formation. ginsenoside F2 164-178 interleukin 6 Homo sapiens 245-249 25591756-12 2015 But IL-6 could counteract the anti-apoptotic effects of MDZ. Midazolam 56-59 interleukin 6 Homo sapiens 4-8 25455727-8 2015 The IL-6 level was also significantly higher in the DS group (8.022 +- 0.161 pg/mL) than in either the IS or the control group (7.783 +- 0.0563 and 7.864 +- 0.072 pg/mL; p<0.005 and p<0.05, respectively). Deuterium 52-54 interleukin 6 Homo sapiens 4-8 32892075-7 2020 Additionally, DHA in vivo improved the clinical symptoms, reduced the production of pro-inflammatory factors IL-1beta, IL-6 and TNF-alpha, and suppressed the formation of NLRP3 inflammasome. artenimol 14-17 interleukin 6 Homo sapiens 119-123 25964862-13 2014 In contrast, tumors with high epithelial IL-6 expression displayed a dense infiltration of mature myeloid cells and were correlated with a shorter DSS. dss 147-150 interleukin 6 Homo sapiens 41-45 25564572-10 2015 The inhibition of IGFIR activation by either RNA interference or by treatment with the inhibitor picropodophyllin (PPP) significantly suppressed the IL6-induced stemness-related properties both in vitro and in vivo. picropodophyllin 97-113 interleukin 6 Homo sapiens 149-152 25564572-10 2015 The inhibition of IGFIR activation by either RNA interference or by treatment with the inhibitor picropodophyllin (PPP) significantly suppressed the IL6-induced stemness-related properties both in vitro and in vivo. picropodophyllin 115-118 interleukin 6 Homo sapiens 149-152 32515499-9 2020 IL-6 was not different at baseline (P = .41), while 24 to 48 hours post-tocilizumab IL-6 serum levels were significantly higher in nonsurvivors than in survivors (2398.5 [430.5-9372] vs 290.5 [58.5-1305.5] pg/mL, P = .022). post- 67-72 interleukin 6 Homo sapiens 84-88 25790671-0 2015 [Effect of Sanhuang Yilong Decoction combined MTX on the expression of serum IL-1, IL-6, and IL-17 in rheumatoid arthritis patients of accumulated dampness-heat syndrome]. Methotrexate 46-49 interleukin 6 Homo sapiens 83-87 25790671-1 2015 OBJECTIVE: To study the effect of bitter-cold herbs easing dampness method (BCHEDM) plus Sanhuang Yilong Decoction (SYD) combined with methotrexate (MTX) on expression levels of interleukin-1 (IL-1), IL-6, and IL-17 in rheumatoid arthritis (RA) patients of accumulated dampness-heat syndrome (ADHS). Methotrexate 149-152 interleukin 6 Homo sapiens 200-204 25790671-9 2015 CONCLUSION: SYD combined MTX could play roles of improving inflammatory indices within 2 weeks, and inhibiting the expression of IL-1, IL-6, and IL-17 within 4 weeks. Methotrexate 25-28 interleukin 6 Homo sapiens 135-139 24130267-9 2015 NBQX reduced GluR abundance, knee swelling (p<0.001, days 1-21), gait abnormalities (days 1-2), end-stage joint destruction (p<0.001), synovial inflammation (p<0.001), and messenger RNA expression of meniscal IL-6 (p<0.05) and whole joint cathepsin K (p<0.01). 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline 0-4 interleukin 6 Homo sapiens 218-222 24285492-8 2015 RESULTS: In rheumatoid arthritis synovial fibroblasts (RASF), FFA dose-dependently enhanced the secretion of the proinflammatory cytokine IL-6, the chemokines IL-8 and MCP-1, as well as the matrix-degrading enzymes pro-MMP1 and MMP3. Fatty Acids, Nonesterified 62-65 interleukin 6 Homo sapiens 138-142 26273599-5 2015 Markedly decreased levels of IL-17, retinoid-related orphan receptor C (RORc), and MMP-3 mRNA expression were also observed in IL-6-induced RASFs in the presence of T-614 or MTX compared with those in its absence. Methotrexate 174-177 interleukin 6 Homo sapiens 127-131 32433216-12 2020 Serum H2S on day 1 was negatively correlated with IL- 6 and CRP and positively correlated with the absolute lymphocyte count in peripheral blood. Deuterium 6-9 interleukin 6 Homo sapiens 50-55 25688369-4 2015 ICA upregulated the expression of SIRT6 and had an inhibitory effect on NF-kappaB inflammatory signaling pathways as shown by decreasing mRNA levels of the NF-kappaB downstream target genes TNF-alpha, ICAM-1, IL-2, and IL-6. icariin 0-3 interleukin 6 Homo sapiens 219-223 25624847-10 2014 In hemodialyzed patients NTBI correlated with hsCRP (r = 0.37, p < 0.01), ferritin (r = 0.41, p < 0.001), IL-6 (r = 0.43, p < 0.001). ntbi 25-29 interleukin 6 Homo sapiens 112-116 25064746-0 2014 Therapeutic benefit of bortezomib on acute graft-versus-host disease is tissue specific and is associated with interleukin-6 levels. Bortezomib 23-33 interleukin 6 Homo sapiens 111-124 25064746-6 2014 Reduced skin GVHD by bortezomib was correlated with reduced serum and skin IL-6 levels. Bortezomib 21-31 interleukin 6 Homo sapiens 75-79 24644198-6 2014 RESULTS: Methadone, oxycodone and diamorphine inhibited the production of IL-6 by IL-2 stimulated PBMCs. Heroin 34-45 interleukin 6 Homo sapiens 74-78 25479910-9 2014 In vivo ET-743 induced a deregulation of genes involved in cell adhesion, stress-related response, and in pathways involved in cholangiocarcinogenesis, such as the IL-6, Sonic Hedgehog and Wnt signaling pathways. Trabectedin 8-14 interleukin 6 Homo sapiens 164-168 33009434-6 2020 The aqueous levels of IL-10, IL-12, and TNF-alpha, and the IL-10/IL-6 ratio significantly decreased at 1 month after intravitreal MTX therapy onset compared with the baseline values (P = 0.001, 0.002, 0.001, and 0.001, respectively). Methotrexate 130-133 interleukin 6 Homo sapiens 65-69 25319951-6 2014 RESULTS: Compared with placebo, rosuvastatin treatment significantly reduced the incidence of periprocedural myocardial infarction (PMI) and levels of cardiac troponin I (cTnI) associated with decreased relative expression of serum miR-155, levels of inflammatory cytokines (INF-gamma, TNF-alpha, and IL-6), increased SHIP-1 expression and CD4(+)FoxP3(+)Treg percentage values (P < 0.05). Rosuvastatin Calcium 32-44 interleukin 6 Homo sapiens 301-305 25181692-19 2014 Blockade of IL6 signaling with tocilizumab, a drug approved by the Food and Drug Administration for treatment of rheumatoid arthritis, inhibits TAM-stimulated activity of CD44(+) cells. tam 144-147 interleukin 6 Homo sapiens 12-15 24051251-5 2014 Frequency of following genotypes were significantly lower in patients with CIU, compared to controls: AG at -308 and GA at -238 of TNF-alpha gene (p<0.05 and p<0.001, respectively), CG at -174 and GG at +565 of IL-6 gene (p<0.05). n-cyclohexyl-n'-(4-iodophenyl)urea 75-78 interleukin 6 Homo sapiens 217-221 24051251-6 2014 Additionally, following genotypes were more common among patients with CIU: GG at -308 and -238 of TNF-alpha gene (p<0.05 and p<0.001, respectively), GG at -174 and GA at +565 of IL-6 gene (p<0.05). n-cyclohexyl-n'-(4-iodophenyl)urea 71-74 interleukin 6 Homo sapiens 185-189 24051251-8 2014 TNF-alpha promoter polymorphisms as well as IL-6 gene polymorphisms are associated with CIU. n-cyclohexyl-n'-(4-iodophenyl)urea 88-91 interleukin 6 Homo sapiens 44-48 32603665-10 2020 Moreover, the induction of IKBKE by TAMs in TNBC cells was identified to be associated with STAT3 signaling, which was activated by TAM-secreted IL-6 and IL-10. tam 36-39 interleukin 6 Homo sapiens 145-149 32564679-4 2020 We found that viability and inflammatory factor release, including interleukin-1beta (IL-1beta) and IL-6, were negatively related to miR-375-3p expression in HaCaT cells. mir-375-3p 133-143 interleukin 6 Homo sapiens 100-104 25330300-12 2014 MTX at a concentration of 10 microM also increased inflammatory cytokines (IL-1beta, IL-6, TNFalpha and Iggamma) and decreased the level of IL-10 anti-inflammatory cytokine, independent of SOD2 genetic background. Methotrexate 0-3 interleukin 6 Homo sapiens 85-89 25393884-6 2014 The exposure of activated microglia to RBV led to: decrease in the level of NO as a result of decreased cell number, lower average cell surface, the reduction of membrane ruffling, the suppression of interleukin-6 release and promoted interleukin-10 production. Ribavirin 39-42 interleukin 6 Homo sapiens 200-213 32232846-10 2020 The proportion of leukaemic cells in bone marrow on infusion day and the peaks of IL-6, TNF-alpha and IL-8 levels were correlated with CRS levels. 3-cresol 135-138 interleukin 6 Homo sapiens 82-86 25092526-8 2014 RESULTS: Mannan, beta-glucans (curdlan), chitosan, and zymosan induced the secretion of interleukin (IL)-1beta, IL-6, IL-23, IL-10, and tumor necrosis factor-alpha by PBMCs. Mannans 9-15 interleukin 6 Homo sapiens 112-116 24176765-11 2014 New data presented here shows that 20(OH)D3 inhibits LPS-induced production of TNFalpha in the J774 line, TNFalpha and IL-6 in peritoneal macrophages and suppresses the production of proinflammatory Th1/Th17-related cytokines, while promoting the production of the anti-inflammatory cytokine IL-10 in vivo. 20-hydroxyvitamin D3 35-43 interleukin 6 Homo sapiens 119-123 32841551-12 2020 Moreover, the results showed that the neuroinflammation factors (TNF-alpha, IL-6, IL-1beta) in DCA treatment groups increased significantly compared with the control pups. Dichloroacetic Acid 95-98 interleukin 6 Homo sapiens 76-80 24821440-6 2014 In human kidney tubule cells, GB88 inhibited cytokine secretion (IL6, IL8, GM-CSF, TNF-alpha) mediated by PAR2. GB88 30-34 interleukin 6 Homo sapiens 65-68 24786833-8 2014 In contrast, SAG-overexpressing macrophages challenged with PAMPs exhibited upregulation of protumorigenic cytokines (IL-1beta, IL-6 and TNF-alpha), and downregulation of antitumorigenic cytokine (IL-12p40) and anti-inflammatory cytokine (IL-10). sagopilone 13-16 interleukin 6 Homo sapiens 128-132 25452693-4 2014 In this study, we found that WFA effectively induces dose-dependent cell death in high-risk and drug-resistant NB as well as multiple myeloma (MM) tumor cells, prevented interleukin-6 (IL-6)-mediated and persistently activated STAT3 phosphorylation at Y705, and blocked the transcriptional activity of STAT3. withaferin A 29-32 interleukin 6 Homo sapiens 170-183 25452693-4 2014 In this study, we found that WFA effectively induces dose-dependent cell death in high-risk and drug-resistant NB as well as multiple myeloma (MM) tumor cells, prevented interleukin-6 (IL-6)-mediated and persistently activated STAT3 phosphorylation at Y705, and blocked the transcriptional activity of STAT3. withaferin A 29-32 interleukin 6 Homo sapiens 185-189 25214403-6 2014 Treatment with TDPs markedly attenuated the taurocholate-induced increase in plasma levels of CXCL2 and interleukin-6. Taurocholic Acid 44-56 interleukin 6 Homo sapiens 104-117 33061451-0 2020 IL-6/STAT3 Signaling Contributes to Sorafenib Resistance in Hepatocellular Carcinoma Through Targeting Cancer Stem Cells. Sorafenib 36-45 interleukin 6 Homo sapiens 0-4 25411629-9 2014 Increased baseline levels of hs-CRP, TNF-alpha and IL-6 were associated with renal impairment and cognitive function, especially DSS tests, respectively. dss 129-132 interleukin 6 Homo sapiens 51-55 33061451-3 2020 The inflammatory factor interleukin 6 (IL-6) plays a role in sorafenib resistance in HCC. Sorafenib 61-70 interleukin 6 Homo sapiens 24-37 24833103-10 2014 IL-6 expression was significantly higher in mesenchymal tumors, and knockdown of IL-6 in mesenchymal HCC cell lines increased E-cadherin expression and sensitivity to sorafenib. Sorafenib 167-176 interleukin 6 Homo sapiens 81-85 33061451-3 2020 The inflammatory factor interleukin 6 (IL-6) plays a role in sorafenib resistance in HCC. Sorafenib 61-70 interleukin 6 Homo sapiens 39-43 23952046-10 2014 This was significantly decreased in a dose-dependent manner by NBD peptide or SP600125 [maximum inhibition ~30-40% (p < 0.02)], and together, the two inhibitors decreased IL-6 by ~80%, similar to the inhibition caused by NDM (p < 0.001). pyrazolanthrone 78-86 interleukin 6 Homo sapiens 174-178 33061451-4 2020 However, the mechanism by which IL-6 in LCSCs is involved in the process of HCC sorafenib resistance remains elusive. Sorafenib 80-89 interleukin 6 Homo sapiens 32-36 33061451-9 2020 Finally, a xenograft model was used to evaluate the function of IL-6 in the sorafenib resistance of HCC. Sorafenib 76-85 interleukin 6 Homo sapiens 64-68 25374024-3 2014 Curcuminoids supplementation led to significant decreases in serum A-FABP, C-reactive protein (CRP), tumor necrosis factor-alpha, and interleukin-6 levels. curcuminoids 0-12 interleukin 6 Homo sapiens 134-147 33061451-12 2020 Downregulation of IL-6 expression with short hairpin RNA (shRNA) restored sorafenib sensitivity in resistant LCSCs, suggesting the critical roles of IL-6/STAT3 in inducing sorafenib resistance. Sorafenib 74-83 interleukin 6 Homo sapiens 18-22 24939178-0 2014 Regulation of SOD2 and beta-arrestin1 by interleukin-6 contributes to the increase of IGF-1R expression in docetaxel resistant prostate cancer cells. Docetaxel 107-116 interleukin 6 Homo sapiens 41-54 25165111-8 2014 The application of minocycline, an inhibitor of neuroinflammation, altered the WNV-induced proinflammatory cytokine/chemokine expression profile, with inhibited production of CCL5, CCL2, and IL-6. Minocycline 19-30 interleukin 6 Homo sapiens 191-195 33061451-12 2020 Downregulation of IL-6 expression with short hairpin RNA (shRNA) restored sorafenib sensitivity in resistant LCSCs, suggesting the critical roles of IL-6/STAT3 in inducing sorafenib resistance. Sorafenib 172-181 interleukin 6 Homo sapiens 18-22 25280420-8 2014 Palmitic acid was marginally associated with the composite inflammation measure (P = 0.06) and, upon additional omega-6 FA adjustment, significantly associated with IL-6 (15% increase; 95% CI, 0.4%-27%; P = 0.006). omega-6 fa 112-122 interleukin 6 Homo sapiens 165-169 33061451-13 2020 Furthermore, a xenograft tumor model showed that IL-6 downregulation improved the antitumor effect of sorafenib. Sorafenib 102-111 interleukin 6 Homo sapiens 49-53 24500697-0 2014 Differential effects of low and high doses of lipoteichoic acid on lipopolysaccharide-induced interleukin-6 production. lipoteichoic acid 46-63 interleukin 6 Homo sapiens 94-107 33061451-14 2020 Conclusion: LCSCs play an important role in sorafenib-resistant HCC, and inhibition of the IL-6/STAT3 signaling pathway improves the antitumor effects of sorafenib against HCC in vitro and in vivo. Sorafenib 154-163 interleukin 6 Homo sapiens 91-95 24500697-2 2014 Here, we examined the priming effect of lipoteichoic acid (LTA) and lipopolysaccharide (LPS) on IL-6 production in a monocyte-like cell line. lipoteichoic acid 40-57 interleukin 6 Homo sapiens 96-100 33061451-15 2020 These findings demonstrate that IL-6 in LCSCs may function as a novel target for combating sorafenib resistance in HCC. Sorafenib 91-100 interleukin 6 Homo sapiens 32-36 24500697-2 2014 Here, we examined the priming effect of lipoteichoic acid (LTA) and lipopolysaccharide (LPS) on IL-6 production in a monocyte-like cell line. lipoteichoic acid 59-62 interleukin 6 Homo sapiens 96-100 32924970-8 2020 Furthermore, DHC decreased the expression of pro-inflammatory cytokines induced by TNF-alpha, such as interleukin-1beta (IL-1beta) and interleukin-6 (IL-6). dehydrocostus lactone 13-16 interleukin 6 Homo sapiens 135-148 24038588-3 2014 The results showed that the JAK/STAT pathway activation by proinflammatory cytokine interleukin-6 and interferon-gamma in CCA cells was suppressed by pretreatment with quercetin and EGCG, evidently by a decrease of the elevated phosphorylated-STAT1 and STAT3 proteins in a dose-dependent manner. Quercetin 168-177 interleukin 6 Homo sapiens 84-97 24885636-9 2014 This response was attenuated by treating TAMs with the KCNN4 channel-specific inhibitor, 1-[(2-chlorophenyl) diphenylmethyl]-1H-pyrazole (TRAM-34), which suggested that KCNN4 channels may be involved in inducing the secretion of IL-6 and IL-8 by TAMs and improving CRC cell invasiveness. TRAM 34 138-145 interleukin 6 Homo sapiens 229-233 25417402-14 2014 SAQ scores of QOL were negatively associated with the inflammatory index (IL-6/IL-10), and there was a significant negative association of IL-10 with AS (r = - 0.15, P < 0.05). 2-[(Thiophen-2-Ylmethyl)amino]-1,7-Dihydro-8h-Imidazo[4,5-G]quinazolin-8-One 0-3 interleukin 6 Homo sapiens 74-78 24928308-7 2014 Furthermore we could observe an increased expression and secretion of pro-inflammatory cytokines like interleukin (IL)-6, IL-8 and MCP-1 (2.5-, 2.4- and 1.5-fold, respectively) by the sDPP4 treatment. sdpp4 184-189 interleukin 6 Homo sapiens 102-120 32924970-8 2020 Furthermore, DHC decreased the expression of pro-inflammatory cytokines induced by TNF-alpha, such as interleukin-1beta (IL-1beta) and interleukin-6 (IL-6). dehydrocostus lactone 13-16 interleukin 6 Homo sapiens 150-154 24928308-11 2014 Additionally, the sDPP4-induced upregulation of IL-6 and IL-8 could completely be prevented by the PAR2 silencing. sdpp4 18-23 interleukin 6 Homo sapiens 48-52 32906766-2 2020 SNAH inhibited the production of NO (nitric oxide), reactive oxygen species (ROS), tumor necrosis factor (TNF)-alpha, and interleukin (IL)-6. snah 0-4 interleukin 6 Homo sapiens 122-140 24817528-14 2014 CONCLUSION: Lower tolerance to NMES was associated with increasing airflow obstruction, low tolerance to leg discomfort during NMES and the magnitude of the IL-6 response after NMES. nmes 31-35 interleukin 6 Homo sapiens 157-161 32343882-0 2020 Association of High Serum Interleukin-6 Levels With Severe Progression of Rheumatoid Arthritis and Increased Treatment Response Differentiating Sarilumab From Adalimumab or Methotrexate in a Post Hoc Analysis. Methotrexate 173-185 interleukin 6 Homo sapiens 26-39 24619424-5 2014 Bortezomib induces AIRAP expression at the transcriptional level early after treatment, concomitantly with polyubiquitinated protein accumulation and HSF activation. Bortezomib 0-10 interleukin 6 Homo sapiens 150-153 23837828-0 2014 Interleukin-6 concentration changes in plasma and saliva in bisphosphonate-related osteonecrosis of the jaws. Diphosphonates 60-74 interleukin 6 Homo sapiens 0-13 23837828-1 2014 AIM: To determine the plasma and saliva levels of IL-6 in patients with bisphosphonate-related osteonecrosis of the jaws (BRONJ) and to investigate whether there is a correlation between more advanced stages of BRONJ and levels of IL-6. Diphosphonates 72-86 interleukin 6 Homo sapiens 50-54 32343882-8 2020 In MOBILITY, compared to patients with low IL-6 levels (n = 397), patients with high IL-6 levels (n = 398) had higher disease activity and joint damage at baseline, were more likely to have joint progression, and had less clinical improvement over 52 weeks" treatment with placebo plus MTX compared to sarilumab 150 mg or 200 mg plus MTX. Methotrexate 286-289 interleukin 6 Homo sapiens 85-89 32343882-8 2020 In MOBILITY, compared to patients with low IL-6 levels (n = 397), patients with high IL-6 levels (n = 398) had higher disease activity and joint damage at baseline, were more likely to have joint progression, and had less clinical improvement over 52 weeks" treatment with placebo plus MTX compared to sarilumab 150 mg or 200 mg plus MTX. Methotrexate 334-337 interleukin 6 Homo sapiens 85-89 24870843-5 2014 However, the combination of methotrexate and biologic DMARDs targeting TNF and IL-6 have revolutionized the treatment of RA, producing significant improvements in clinical, radiographic, and functional outcomes that were not previously observed. Methotrexate 28-40 interleukin 6 Homo sapiens 79-83 24811308-6 2014 RESULTS: After one day on mechanical ventilation and an IL-6 level of 70,000 pg/ml the patient was treated with CytoSorb therapy over a period of four days, resulting in a significant reduction of IL-6 to 66 pg/ml and an overall improvement of the patient"s condition. cytosorb 112-120 interleukin 6 Homo sapiens 56-60 32707536-5 2020 Our study suggests that DHCA is effective in reducing IL-6 expression in human PBMCs, in part, by regulation of methylation in the IL-6 promoter region. 3,4-dihydroxyphenylpropionic acid 24-28 interleukin 6 Homo sapiens 54-58 24811308-6 2014 RESULTS: After one day on mechanical ventilation and an IL-6 level of 70,000 pg/ml the patient was treated with CytoSorb therapy over a period of four days, resulting in a significant reduction of IL-6 to 66 pg/ml and an overall improvement of the patient"s condition. cytosorb 112-120 interleukin 6 Homo sapiens 197-201 24429914-8 2014 Furthermore, JNK pathway might be involved in LPS-induced astrocyte activation because JNK phosphorylation was significantly increased, and the inhibition of this pathway mediated by DEX as well as SP600125 (JNK inhibitor) decreased TNF-alpha and IL-6 expressions. pyrazolanthrone 198-206 interleukin 6 Homo sapiens 247-251 24363043-7 2014 IL-6 production by BSMC was induced by Fsk and select G protein-coupled receptor (GPCR) agonists, though IL-6 levels did not directly correlate with global cAMP levels. Colforsin 39-42 interleukin 6 Homo sapiens 0-4 24363043-9 2014 IL-6 promoter mutations demonstrated that AP-1 and CRE transcription sites were required for Fsk to stimulate IL-6 expression. Colforsin 93-96 interleukin 6 Homo sapiens 0-4 24363043-9 2014 IL-6 promoter mutations demonstrated that AP-1 and CRE transcription sites were required for Fsk to stimulate IL-6 expression. Colforsin 93-96 interleukin 6 Homo sapiens 110-114 24722336-0 2014 Association of plasma IL-6 and Hsp70 with HRV at different levels of PAHs metabolites. Polycyclic Aromatic Hydrocarbons 69-73 interleukin 6 Homo sapiens 22-26 24722336-7 2014 In particular, elevated IL-6 was associated in a dose-dependent manner with decreased TP and LF in the high-PAHs metabolites groups (all Ptrend<0.05), but not in the low-PAHs metabolites groups. Polycyclic Aromatic Hydrocarbons 108-112 interleukin 6 Homo sapiens 24-28 24722336-7 2014 In particular, elevated IL-6 was associated in a dose-dependent manner with decreased TP and LF in the high-PAHs metabolites groups (all Ptrend<0.05), but not in the low-PAHs metabolites groups. Polycyclic Aromatic Hydrocarbons 173-177 interleukin 6 Homo sapiens 24-28 32707536-5 2020 Our study suggests that DHCA is effective in reducing IL-6 expression in human PBMCs, in part, by regulation of methylation in the IL-6 promoter region. 3,4-dihydroxyphenylpropionic acid 24-28 interleukin 6 Homo sapiens 131-135 24722336-10 2014 We also observed that both IL-6 and Hsp70 significantly interacted with multiple PAHs metabolites in relation to HRV. Polycyclic Aromatic Hydrocarbons 81-85 interleukin 6 Homo sapiens 27-31 24722336-11 2014 CONCLUSIONS: In coke oven workers, increased IL-6 was associated with a dose-response decreased HRV in the high-PAHs metabolites groups, whereas increase of Hsp70 can result in significant dose-related increase in HRV in the low-PAHs metabolites groups. Polycyclic Aromatic Hydrocarbons 112-116 interleukin 6 Homo sapiens 45-49 24513290-7 2014 Furthermore, curcumin, a histone acetyltransferase (HAT) inhibitor, significantly reduced the level of H3ac in the IL-6 promoter, as well as IL-6 mRNA expression and IL-6 protein secretion by RASFs. h3ac 103-107 interleukin 6 Homo sapiens 115-119 32884345-0 2020 Allicin Inhibits Proliferation by Decreasing IL-6 and IFN-beta in HCMV-Infected Glioma Cells. allicin 0-7 interleukin 6 Homo sapiens 45-49 24444433-0 2014 Methotrexate induces production of IL-1 and IL-6 in the monocytic cell line U937. Methotrexate 0-12 interleukin 6 Homo sapiens 44-48 24444433-8 2014 RESULTS: MTX mediated a dose-dependent increase in IL-1 and IL-6 in U937 cells, as measured by secreted proteins and levels of gene expression. Methotrexate 9-12 interleukin 6 Homo sapiens 60-64 24722336-11 2014 CONCLUSIONS: In coke oven workers, increased IL-6 was associated with a dose-response decreased HRV in the high-PAHs metabolites groups, whereas increase of Hsp70 can result in significant dose-related increase in HRV in the low-PAHs metabolites groups. Polycyclic Aromatic Hydrocarbons 229-233 interleukin 6 Homo sapiens 45-49 24410968-6 2014 In the CRP-transgenic strain, we found that rosuvastatin treatment decreased circulating levels of inflammatory response markers IL6 and TNFalpha without decreasing circulating levels of human CRP. Rosuvastatin Calcium 44-56 interleukin 6 Homo sapiens 129-132 32884345-12 2020 After treatment with allicin, p53 levels increased significantly, whereas expression of the inflammatory factors such as IL-6 and IFN-beta decreased. allicin 21-28 interleukin 6 Homo sapiens 121-125 32267089-8 2020 Jatrophone treatment significantly alleviated RSV mediated overproduction of IL-6/-8 and suppressed ROS generation in the cells. jatrophone 0-10 interleukin 6 Homo sapiens 77-84 25237354-5 2014 SERUM CONCENTRATIONS OF SAA (P: 0.02), CRP (P: 0.02) and ferritin (P: 0.01) significantly reduced in heparin group during measurements compared to baseline, circulating levels of IL-6 (P: 0.002), SAA (P: 0.009), CRP (P: 0.01) were significantly decreased in enoxaparin group. Enoxaparin 258-268 interleukin 6 Homo sapiens 179-183 24483976-14 2014 The mean CRP was higher in deceased patients: 13.07 mg/dL - 8.97 mg/dL (p = 0.001), the correlation improved with more days on AMV (p = 0.034 and p = 0.010) and the AUC increased in a similar way to IL-6 in the original work (0.008 and 0.007, respectively). amprenavir 127-130 interleukin 6 Homo sapiens 199-203 32468015-4 2020 Therefore, the aim of the present study was to investigate the effect of AK094629 on IL-1beta-induced IL-6 expression in synovial-derived mesenchymal stem cells (SMSCs) of the temporomandibular joints. ak094629 73-81 interleukin 6 Homo sapiens 102-106 24025977-9 2013 IL-1beta and IL-6 showed significant correlations with PHES, but showed no relationship with critical flicker frequency. phes 55-59 interleukin 6 Homo sapiens 13-17 24576911-0 2014 Interleukin-6 enhances manganese accumulation in SH-SY5Y cells: implications of the up-regulation of ZIP14 and the down-regulation of ZnT10. Manganese 23-32 interleukin 6 Homo sapiens 0-13 24576911-6 2014 The pretreatment of SH-SY5Y cells with interleukin-6 (IL-6) markedly increased the accumulation of manganese to approx. Manganese 99-108 interleukin 6 Homo sapiens 39-52 24576911-6 2014 The pretreatment of SH-SY5Y cells with interleukin-6 (IL-6) markedly increased the accumulation of manganese to approx. Manganese 99-108 interleukin 6 Homo sapiens 54-58 24576911-8 2014 The treatment of SH-SH5Y cells with IL-6 clearly decreased both the mRNA and protein levels of ZnT10 with a concomitant decrease in the manganese excretion efficiency. Manganese 136-145 interleukin 6 Homo sapiens 36-40 32468015-7 2020 The present study also demonstrated that AK094629 knockdown downregulated the expression of the mitogen-activated protein kinase kinase kinase 4 (MAP3K4), which is upregulated by IL-1beta, whereas knockdown of MAP3K4 did not affect the expression of AK094629, but reversed the upregulation of IL-6 in SMSCs. ak094629 41-49 interleukin 6 Homo sapiens 293-297 24576911-9 2014 These results suggest that both the up-regulation of ZIP14 and the down-regulation of ZnT10 by IL-6 might have enhanced the accumulation of manganese in SH-SY5Y cells. Manganese 140-149 interleukin 6 Homo sapiens 95-99 24177007-5 2013 These dual effects would be mediated through endoplasmic reticulum (ER) stress, because we observed (1) up-regulation of GRP78 and CHOP under glucose-deprived condition, which was inhibited by chemical chaperon TMAO, and (2) treatment with TMAO inhibited IL-6 production under glucose-deprived condition. trimethyloxamine 211-215 interleukin 6 Homo sapiens 255-259 32468015-8 2020 In conclusion, AK094629 knockdown attenuated the expression of IL-1beta-regulated IL-6 in the SMSCs of the temporomandibular joint by inhibiting MAP3K4. ak094629 15-23 interleukin 6 Homo sapiens 82-86 24415766-4 2014 Two classes of IL-6 SOMAmers were isolated from modified DNA libraries containing 40 random positions and either 5-(N-benzylcarboxamide)-2"-deoxyuridine (Bn-dU) or 5-[N-(1-naphthylmethyl)carboxamide]-2"-deoxyuridine (Nap-dU) replacing dT. 5-(n-benzylcarboxamide)-2"-deoxyuridine 113-152 interleukin 6 Homo sapiens 15-19 32312453-1 2020 A novel impedimetric immunosensor based on a conjugated polypyrrole polymer containing epoxy active side groups (PPCE) modified indium tin oxide (ITO) electrode was developed for detection of interleukin 6 (IL 6), a prostate cancer biomarker. indium tin oxide 128-144 interleukin 6 Homo sapiens 192-205 24212838-10 2013 CONCLUSIONS: All of the fixed combinations induced a significant reduction in intraocular pressure, and the travoprost/timolol group showed increased expression of the inflammatory markers HLA-DR and interleukin-6. Travoprost 108-118 interleukin 6 Homo sapiens 200-213 32312453-1 2020 A novel impedimetric immunosensor based on a conjugated polypyrrole polymer containing epoxy active side groups (PPCE) modified indium tin oxide (ITO) electrode was developed for detection of interleukin 6 (IL 6), a prostate cancer biomarker. indium tin oxide 128-144 interleukin 6 Homo sapiens 207-211 24415057-2 2014 We found that local cationic anesthetics such as procaine, lidocaine and tetracaine greatly facilitated the electroporation of AT2 rat prostate carcinoma cells and human skin fibroblasts (HSF). Tetracaine 73-83 interleukin 6 Homo sapiens 188-191 24065523-3 2013 Free fatty acids (FFAs) and adipokines, such as tumor necrosis factor-alpha (TNF-alpha), leptin, resistin, and interleukin-6 (IL-6), have already been identified as main regulators of obesity and insulin sensitivity. Fatty Acids, Nonesterified 0-16 interleukin 6 Homo sapiens 111-124 32792961-4 2020 Both TRYP and TRYP-Ox inhibited matrix metalloproteinase (MMP)-3 gene expression in interleukin (IL)-1beta-stimulated primary human FLS, as well as IL-1beta-induced secretion of MMP-1/3 by FLS and synovial SW982 cells and IL-6 by FLS, SW982 cells, human umbilical vein endothelial cells (HUVECs), and monocytic THP-1 cells, although TRYP-Ox was generally more effective and had no cytotoxicity in vitro. tryptanthrine 14-18 interleukin 6 Homo sapiens 222-226 24065523-3 2013 Free fatty acids (FFAs) and adipokines, such as tumor necrosis factor-alpha (TNF-alpha), leptin, resistin, and interleukin-6 (IL-6), have already been identified as main regulators of obesity and insulin sensitivity. Fatty Acids, Nonesterified 0-16 interleukin 6 Homo sapiens 126-130 24289890-9 2014 Moreover, it is suggested that an appropriate therapeutic intervention to reduce CSF IL-6 would be required as early as possible upon diagnosis of CPNB. cpnb 147-151 interleukin 6 Homo sapiens 85-89 32718086-4 2020 Results have been encouraging, particularly when anti-IL-6 has been used with other drugs, such as metothrexate (MTX). Methotrexate 113-116 interleukin 6 Homo sapiens 54-58 24523548-9 2014 Nonetheless, RSD-induced expression of IL-1beta, TNF-alpha, and IL-6 mRNA in brain CD11b(+) cells was attenuated in eIL-1R1kd mice compared with WT. RSD 13-16 interleukin 6 Homo sapiens 64-68 23084463-6 2013 RESULTS: In cirrhotic patients with OHE, the severity of OHE, represented by the West Haven criteria, correlated with serum IL-6 levels (r=0.43, P<0.05) and plasma ammonia levels (r=0.59, P<0.05). (E)-4-oxohex-2-enal 36-39 interleukin 6 Homo sapiens 124-128 23084463-6 2013 RESULTS: In cirrhotic patients with OHE, the severity of OHE, represented by the West Haven criteria, correlated with serum IL-6 levels (r=0.43, P<0.05) and plasma ammonia levels (r=0.59, P<0.05). (E)-4-oxohex-2-enal 57-60 interleukin 6 Homo sapiens 124-128 23084463-9 2013 Moreover, there was a significant positive correlation between serum IL-6 levels and plasma ammonia levels (r=0.58, P<0.05) in cirrhotic patients with OHE, but not in patients without OHE (r=0.42, P>0.05) or healthy controls (r=0.27, P>0.05). (E)-4-oxohex-2-enal 154-157 interleukin 6 Homo sapiens 69-73 32652935-14 2020 Follow-up after 6 months of rosuvastatin therapy showed a significantly greater reduction in hs-CRP and IL-6 levels in the CAE-A group than in the CAE-B group, which again were greater in the CAE-B group than in the CAE-C group. Rosuvastatin Calcium 28-40 interleukin 6 Homo sapiens 104-108 32614271-0 2020 Interleukin-6-Mediated Inflammation May Cause Methotrexate-Induced Leukoencephalopathy. Methotrexate 46-58 interleukin 6 Homo sapiens 0-13 24044679-9 2013 However, only IL-6 production was significantly increased with GB. gb 63-65 interleukin 6 Homo sapiens 14-18 24232001-5 2014 Pre- and coadministration of paeoniflorin significantly reduced the severity of colitis and resulted in downregulation of several inflammatory parameters in the colon, including the activity of myeloperoxidase (MPO), the levels of TNF-alpha and IL-6, and the mRNA expression of proinflammatory mediators (MCP-1, Cox2, IFN-gamma, TNF-alpha, IL-6, and IL-17). peoniflorin 29-41 interleukin 6 Homo sapiens 245-249 24232001-5 2014 Pre- and coadministration of paeoniflorin significantly reduced the severity of colitis and resulted in downregulation of several inflammatory parameters in the colon, including the activity of myeloperoxidase (MPO), the levels of TNF-alpha and IL-6, and the mRNA expression of proinflammatory mediators (MCP-1, Cox2, IFN-gamma, TNF-alpha, IL-6, and IL-17). peoniflorin 29-41 interleukin 6 Homo sapiens 340-344 32614271-5 2020 CSF IL-6 concentrations were higher in children with MTX-induced leukoencephalopathy than in children with acute leukemia with PRES, with acute leukemia without neurological complications, and with acute encephalopathy. Methotrexate 53-56 interleukin 6 Homo sapiens 4-8 24500009-0 2014 A citrus flavonoid, 6-demethoxytangeretin, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase and mitogen-activated protein kinase pathways. Flavonoids 9-18 interleukin 6 Homo sapiens 88-101 23800440-6 2013 Interleukin-6 levels were significantly elevated by 4 h after exposure to npOMV and pOMVs. npomv 74-79 interleukin 6 Homo sapiens 0-13 32614271-6 2020 We concluded that IL-6 may be involved in the pathogenesis of MTX-induced leukoencephalopathy. Methotrexate 62-65 interleukin 6 Homo sapiens 18-22 32536965-14 2020 Second, the molecular docking results showed that there was a certain affinity between the core compounds (kaempferol, quercetin, 7-Methoxy-2-methyl isoflavone, naringenin, formononetin) and core target genes (IL6, IL1B, CCL2). Quercetin 119-128 interleukin 6 Homo sapiens 210-213 26155163-6 2014 Our data indicated that paeoniflorin directly inhibited activation of NF-kappaB p65, thereby reduced the expression of TNF-alpha and IL-6 in the BLP stimulated THP-1 cells. peoniflorin 24-36 interleukin 6 Homo sapiens 133-137 32536965-14 2020 Second, the molecular docking results showed that there was a certain affinity between the core compounds (kaempferol, quercetin, 7-Methoxy-2-methyl isoflavone, naringenin, formononetin) and core target genes (IL6, IL1B, CCL2). formononetin 173-185 interleukin 6 Homo sapiens 210-213 23991101-7 2013 This massive in vitro evidence supports the hypotheses that SMF-exposure (i) is harmful to lymphocytes in itself, (ii) suppresses the release of pro-inflammatory cytokines IL-6, IL-8, and TNF-alpha, and (iii) assists the production of anti-inflammatory cytokine IL-10; thus providing a background mechanism of the earlier in vivo demonstrated anti-inflammatory effects of SMF-exposure. smf 60-63 interleukin 6 Homo sapiens 172-176 32517784-0 2020 Modified Pulsatillae decoction inhibits DSS-induced ulcerative colitis in vitro and in vivo via IL-6/STAT3 pathway. dss 40-43 interleukin 6 Homo sapiens 96-100 23959753-4 2013 RESULTS: Higher baseline serum IL-6 levels were significantly associated (p<0.0001) with higher baseline DAS28, erythrocyte sedimentation rate, C reactive protein and Health Assessment Questionnaire in patients whose responses to disease-modifying antirheumatic drugs (DMARD-IR) and to antitumour necrosis factor (aTNF-IR) were inadequate and patients who were naive/responders to methotrexate (MTX). Methotrexate 384-396 interleukin 6 Homo sapiens 31-35 23959753-4 2013 RESULTS: Higher baseline serum IL-6 levels were significantly associated (p<0.0001) with higher baseline DAS28, erythrocyte sedimentation rate, C reactive protein and Health Assessment Questionnaire in patients whose responses to disease-modifying antirheumatic drugs (DMARD-IR) and to antitumour necrosis factor (aTNF-IR) were inadequate and patients who were naive/responders to methotrexate (MTX). Methotrexate 398-401 interleukin 6 Homo sapiens 31-35 23959753-5 2013 Higher baseline serum IL-6 levels were also significantly associated with better clinical response to tocilizumab (versus placebo) measured by cDAS28 in the pooled DMARD-IR (p<0.0001) and MTX-naive populations (p=0.04). Methotrexate 191-194 interleukin 6 Homo sapiens 22-26 24345236-7 2014 The majority of the IL-6 release and cytotoxicity was induced upon exposure to the most polar (methanol) SPE fraction of extracts from both samples. Methanol 95-103 interleukin 6 Homo sapiens 20-24 23775574-8 2013 And also immune reaction was less in patients exposed to desflurane anesthesia when compared to propofol anesthesia as indicated by lower plasma concentrations of IL-8 and IL-6. Desflurane 57-67 interleukin 6 Homo sapiens 172-176 32421092-6 2020 Other possible IL-6 pathway inhibitors such as Ruxolitinib and Baricinitib are then analyzed, underlying how they lack the benefit of targeting only the pro-inflammatory pathway. baricinitib 63-74 interleukin 6 Homo sapiens 15-19 24219725-11 2013 The protein expressions of IL-6, IL-8, MMP-8, eNOS and iNOS were more prominent in the after FCB and SL groups than in the NP and the before FCB groups. beta-D-Fucose 93-96 interleukin 6 Homo sapiens 27-31 24244812-3 2013 Treatment with SB-657510 significantly inhibited UII-induced expression of IL-1beta, IL-6, and VCAM-1 in EA.hy926 cells. SB 657510 15-24 interleukin 6 Homo sapiens 85-89 23722391-7 2013 RESULTS: DEP significantly decreased the viability, proliferation, and secretion of IL-8, but increased the secretion of IL-6 on both HCLE and IOBA-NHC cell lines in a dose-dependent manner. hcle 134-138 interleukin 6 Homo sapiens 121-125 32348149-3 2020 Benefiting from multi-enzyme activities against RONS, Rh-PEG NDs can decrease the levels of pro-inflammatory cytokines (TNF-alpha, IL-6), resulting in good anti-inflammatory effect on dextran sulfate sodium-induced colitis. Dextran Sulfate 184-206 interleukin 6 Homo sapiens 131-135 23861862-5 2013 In the non-ischemic group, the level of IL-6 was significantly associated with inner CMT (r = 0.560; P = 0.03). cmt 85-88 interleukin 6 Homo sapiens 40-44 23941872-3 2013 As such, the report that increased release of free fatty acids (FFA) via lipolysis from skeletal muscle, but not from adipose tissue, is responsible for the increased systemic lipolysis during IL-6 infusion in healthy humans is somewhat unexpected (26). Fatty Acids, Nonesterified 46-62 interleukin 6 Homo sapiens 193-197 32204034-5 2020 It is found that macrophages grown on MAO-modified Ti surface were switched to M1-like phenotype, evidenced by the promoted expressions of inflammatory genes (tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and IL-1beta) and production of pro-inflammatory cytokine TNF-alpha. 5'-DEOXY-5'-[N-METHYL-N-(2-AMINOOXYETHYL) AMINO]ADENOSINE 38-41 interleukin 6 Homo sapiens 200-213 23594598-3 2013 BTH inhibited the release of some of the key psoriatic cytokines such as tumor necrosis factor alpha, IL-8, IL-6, and CCL27 through the downregulation of NF-kappaB in normal human keratinocytes. bth 0-3 interleukin 6 Homo sapiens 108-112 23526221-8 2013 We observed significant up-regulation of IL-1beta and IL-6 in bronchoalveolar lavage fluid (BALF) in bleomycin-induced lung fibrosis in vivo. Bleomycin 101-110 interleukin 6 Homo sapiens 54-58 23526221-9 2013 Importantly, primary fibrotic ATII cells isolated from lungs subjected to bleomycin secreted enhanced IL-1beta and IL-6 in vitro. Bleomycin 74-83 interleukin 6 Homo sapiens 115-119 32204034-5 2020 It is found that macrophages grown on MAO-modified Ti surface were switched to M1-like phenotype, evidenced by the promoted expressions of inflammatory genes (tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and IL-1beta) and production of pro-inflammatory cytokine TNF-alpha. 5'-DEOXY-5'-[N-METHYL-N-(2-AMINOOXYETHYL) AMINO]ADENOSINE 38-41 interleukin 6 Homo sapiens 215-219 23824089-8 2013 Finally, blocking of NF-kappaB with Bay11-7082 prevented CSE-induced EMT and malignant transformation due to decreases of E-cadherin and miR-200c and elevations of IL-6, N-cadherin, and vimentin. 3-(4-methylphenylsulfonyl)-2-propenenitrile 36-46 interleukin 6 Homo sapiens 164-168 32191437-6 2020 Furthermore, treatment with laquinimod suppressed IL-1beta-induced production of TNF-alpha and IL-6. laquinimod 28-38 interleukin 6 Homo sapiens 95-99 23597726-8 2013 MAO subjects also had increased plasma concentrations of IL-22 and IL-6. 5'-DEOXY-5'-[N-METHYL-N-(2-AMINOOXYETHYL) AMINO]ADENOSINE 0-3 interleukin 6 Homo sapiens 67-71 24049596-9 2013 Quercetin supplementation significantly reduced the serum concentration of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) (P = 0.01 and P < 0.0001, respectively); however, the mean changes in serum levels of IL-6, TNF-alpha, and high-sensitivity C-reactive protein were not significant between the groups. Quercetin 0-9 interleukin 6 Homo sapiens 119-132 24049596-9 2013 Quercetin supplementation significantly reduced the serum concentration of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) (P = 0.01 and P < 0.0001, respectively); however, the mean changes in serum levels of IL-6, TNF-alpha, and high-sensitivity C-reactive protein were not significant between the groups. Quercetin 0-9 interleukin 6 Homo sapiens 134-138 24049596-9 2013 Quercetin supplementation significantly reduced the serum concentration of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) (P = 0.01 and P < 0.0001, respectively); however, the mean changes in serum levels of IL-6, TNF-alpha, and high-sensitivity C-reactive protein were not significant between the groups. Quercetin 0-9 interleukin 6 Homo sapiens 229-233 32041439-10 2020 Sulforaphane significantly inhibited the levels of inflammatory mediators including TSLP, tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8 in a dose-dependent manner. sulforaphane 0-12 interleukin 6 Homo sapiens 149-153 23499872-4 2013 Cambinol inhibited the expression of cytokines (TNF, IL-1beta, IL-6, IL-12p40, and IFN-gamma), NO and CD40 by macrophages, dendritic cells, splenocytes and whole blood stimulated with a broad range of microbial and inflammasome stimuli. cambinol 0-8 interleukin 6 Homo sapiens 63-67 23590633-9 2013 In HMC-1 cells, [6]-shogaol inhibited the production of TNF-alpha, IL-6 and IL-8, as well as the activation of nuclear factor-kappaB (NF-kappaB) and phosphorylation of JNK in compound 48/80-induced HMC-1 cells. shogaol 20-27 interleukin 6 Homo sapiens 67-71 32045587-10 2020 Gliclazide significantly alleviated the proinflammatory mediator, IL-6, promoted the anti-inflammatory cytokine, IL-10 and, withheld oxidative stress in the injured colon tissues. Gliclazide 0-10 interleukin 6 Homo sapiens 66-70 23689555-7 2013 Post-treatment with PPs also more efficiently than pretreatment prevented UV-induced overexpression of IL-1 beta, IL-6 and COX2 mRNAs. pps 20-23 interleukin 6 Homo sapiens 114-118 23633491-6 2013 Together these findings offer a rationale for dual inhibition of IL-6/IL-8 signaling as a therapeutic strategy to improve outcomes for patients with TNBCs. tnbcs 149-154 interleukin 6 Homo sapiens 65-69 32131874-10 2020 ROS, MMP-3 expression, and IL-6 was suppressed by administering 30 muM of SP600125 (a JNK inhibitor) in MH7A cells. pyrazolanthrone 74-82 interleukin 6 Homo sapiens 27-31 23588209-10 2013 In addition, TES inhibited the expression of cyclooxygenase (COX)-2 and the phosphorylation of c-Jun NH2-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) MAPKs, suggesting that it inhibits the secretion of the pro-inflammatory cytokines IL-6 and IL-8 and COX-2 expression by blocking MAPK phosphorylation. tectroside 13-16 interleukin 6 Homo sapiens 258-262 23734186-12 2013 This increased secretion of TNF-alpha and IL-6 and activation of NF-kB, ERK, and JNK was significantly inhibited by the addition of either mannan or mannose. Mannans 139-145 interleukin 6 Homo sapiens 42-46 23650203-1 2013 SCOPE: We aimed to study the effects of free fatty acids (FFAs) alone and combined with the exercise mimetics adrenaline and 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) in the production of IL6, IL15 and Irisin in muscle cells, using a time-sequential model. Fatty Acids, Nonesterified 40-56 interleukin 6 Homo sapiens 200-203 23889808-7 2013 RESULTS: The hexadecylamide derivative of HA had significantly better amelioration of IL-1beta-induced gene expression of key matrix degrading enzymes (MMP1, MMP13, ADAMTS5), and inflammatory mediators (IL6, PTGS2) by human OA chondrocytes and synovial fibroblasts. hexadecylamide 13-27 interleukin 6 Homo sapiens 203-206 31732996-8 2020 The WY-14643 increased expression of IL-1beta and IL-6 proteins, and the mRNA expression of IL-8 and LIF, decreased IL-4 expression, and did not affect the mRNA and protein expression of IL-10. pirinixic acid 4-12 interleukin 6 Homo sapiens 50-54 23624146-5 2013 SP600125, an inhibitor of SAPK/JNK, increased the release and the mRNA expression levels of IL-6 induced by IL-1. pyrazolanthrone 0-8 interleukin 6 Homo sapiens 92-96 23624146-9 2013 SP600125 enhanced IL-1-stimulated IL-6 release also in normal human osteoblasts. pyrazolanthrone 0-8 interleukin 6 Homo sapiens 34-38 23038213-0 2013 Nuclear factor-kappa B and interleukin-6 related docetaxel resistance in castration-resistant prostate cancer. Docetaxel 49-58 interleukin 6 Homo sapiens 27-40 32128354-2 2020 In terms of down-regulating the expression of inducible nitric oxide synthase (iNOS), interleukin (IL)-6, and matrix metalloproteinases (MMPs), pre-treatment with the flavonoid baicalein reportedly protects articular chondrocytes against the cytotoxicity of IL-1beta. Flavonoids 167-176 interleukin 6 Homo sapiens 86-104 22999910-0 2013 Rosuvastatin inhibits spontaneous and IL-1beta-induced interleukin-6 production from human cultured osteoblastic cells. Rosuvastatin Calcium 0-12 interleukin 6 Homo sapiens 55-68 22999910-4 2013 The aim of the study was to evaluate the effect of rosuvastatin on IL-6 production by human osteoblasts. Rosuvastatin Calcium 51-63 interleukin 6 Homo sapiens 67-71 22999910-8 2013 RESULTS: Rosuvastatin significantly reduced IL-6 levels in the osteoblast culture medium, both in unstimulated and IL-1beta-stimulated cells. Rosuvastatin Calcium 9-21 interleukin 6 Homo sapiens 44-48 22999910-12 2013 CONCLUSION: Our results show that rosuvastatin decreases IL-6 production by osteoblasts, thereby suggesting a possible inhibiting activity on osteoclast function in an indirect way. Rosuvastatin Calcium 34-46 interleukin 6 Homo sapiens 57-61 23627303-8 2013 SAA predominately promoted expression of the TH17 polarizing cytokine IL-6, which was opposed by 15-epi-lipoxin A4, a counter-regulatory mediator, and ALX/FPR2 ligand. lipoxin A4 97-114 interleukin 6 Homo sapiens 70-74 23425082-17 2013 CONCLUSIONS: Arterial ammonia, inflammatory mediators (TNF-alpha, IL-6, IL-18), and serum endotoxin reduce and MRS abnormalities improve after treatment with lactulose in patients with MHE. Lactulose 158-167 interleukin 6 Homo sapiens 66-70 32071459-12 2020 Real-time PCR showed that 1-100 mumol/L meloxicam or 100 mumol/L aspirin down-regulated significantly the mRNA expression of TNF-alpha and IL-6 of LPS-hDPCs (P<0.05), and 100 mumol/L meloxicam down-regulated IL-6 and TNF-alpha more significantly than 100 mumol/L aspirin of LPS-hDPCs (P<0.05). meloxicam 40-49 interleukin 6 Homo sapiens 139-143 23207169-9 2013 Univariate and multivariate analyses revealed higher pleural IL-6 levels were associated with postoperative minimum PaO2/FiO2 ratio. pao2 116-120 interleukin 6 Homo sapiens 61-65 23339380-10 2013 HMG supplementation was able to reduce the catabolic genes" expression in cultured HACs such as matrix metalloproteinases (MMP1 & MMP3), Interleukin 1, 6 and 8 (IL-1, IL-6 & IL-8), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). Menotropins 0-3 interleukin 6 Homo sapiens 171-175 32071459-12 2020 Real-time PCR showed that 1-100 mumol/L meloxicam or 100 mumol/L aspirin down-regulated significantly the mRNA expression of TNF-alpha and IL-6 of LPS-hDPCs (P<0.05), and 100 mumol/L meloxicam down-regulated IL-6 and TNF-alpha more significantly than 100 mumol/L aspirin of LPS-hDPCs (P<0.05). meloxicam 40-49 interleukin 6 Homo sapiens 211-215 23504962-7 2013 Also, quercetin and quercetin-3-O-glucuronide inhibited ROS-associated inflammation by inhibition of interleukin-6 and tumor necrosis factor-alpha production with suppression of IKKbeta/NF-kappaB phosphorylation. Quercetin 6-15 interleukin 6 Homo sapiens 101-146 32103983-0 2020 LncRNA DANCR Promotes Sorafenib Resistance via Activation of IL-6/STAT3 Signaling in Hepatocellular Carcinoma Cells. Sorafenib 22-31 interleukin 6 Homo sapiens 61-65 23803194-8 2013 Mannan treatment increased the expressions of IL-1beta, TNF-alpha, IL-6 and CD11b and enhanced superoxide production in the PMNs. Mannans 0-6 interleukin 6 Homo sapiens 67-71 23710436-5 2013 CONCLUSIONS: The present study demonstrated that 1,25(OH)2D3 reduced the production of RANKL and the secretion of TNF- alpha , IL-17, and IL-6 in PBMCs of RA patients, which indicated that 1,25(OH)2D3 might be able to decrease damage of cartilage and bone in RA patients by regulating the expression of RANKL signaling pathway and pathway-associated cytokines. (oh)2d3 53-60 interleukin 6 Homo sapiens 138-142 32103983-15 2020 Conclusion: Collectively, our study is the first to elucidate the mechanism of DANCR-mediated sorafenib resistance via PSMD10-IL-6/STAT3 signaling axis, which provides a promising target for developing new therapeutic strategy for sorafenib tolerance of HCC. Sorafenib 94-103 interleukin 6 Homo sapiens 126-130 31549730-9 2020 Both IL-1beta and IL-6 responses were augmented by extracellular ADP or ADP-betaS and were abrogated by PSB0739. adenosine 5'-O-(2-thiodiphosphate) 72-81 interleukin 6 Homo sapiens 18-22 24469880-8 2013 CONCLUSIONS: Increasing the dose of ASA from 75 mg to 150 mg daily or switching ASA 75 mg to clopidogrel 75 mg daily may reduce concentrations of some inflammatory markers (in particular hsCRP, IL-6 and CD40L) in T2DM patients with HPR treated previously with 75 mg of ASA. Clopidogrel 93-104 interleukin 6 Homo sapiens 194-198 23644384-13 2013 Although there were no statistically significant differences in plasma cytokine levels between the three groups, the low-dose fentanyl plus placebo group had significantly higher interleukin-6:interleukin-10 ratio at 24 hours postoperatively (p < 0.0001). Fentanyl 126-134 interleukin 6 Homo sapiens 179-192 32010251-10 2020 Allylestrenol combined with ritodrine can significantly reduce the expression levels of IL-17, IL-10 and IL-6 in TPTL, reduce adverse pregnancy conditions, prolong gestational weeks, and has higher safety and better application value. Ritodrine 28-37 interleukin 6 Homo sapiens 105-109 22677359-6 2013 Lipoxins, resolvins, and protectins derived from various polyunsaturated fatty acids possess anti-inflammatory actions and suppress the production of interleukin-6, and TNF-alpha and VEGF have antiangiogenic actions. Lipoxins 0-8 interleukin 6 Homo sapiens 150-163 23041168-10 2012 Bay 11-7082 (NF-kappaB inhibitor) significantly attenuated the TCOH-induced production of IL-6 in HaCaT cells, but IL-1alpha production was not affected. 3-(4-methylphenylsulfonyl)-2-propenenitrile 0-11 interleukin 6 Homo sapiens 90-94 22864527-6 2013 CONCLUSIONS: Our results suggest that mucosa, stimulated by bisphosphonate released from the bone, can contribute to the development of jaw necrosis, reducing VEGF, and producing IL-6 in consequence of hydroxymethylglutaryl coenzyme A reductase reduction. Diphosphonates 60-74 interleukin 6 Homo sapiens 179-183 31974603-8 2020 Furthermore, MeDIP and RT-qPCR analysis demonstrated that the 5-methylcytosine levels of the IL-6 and TNF receptor-associated factor 6 (TRAF6) promoters were significantly decreased in DNMT1-deficient hDPCs. 5-Methylcytosine 62-78 interleukin 6 Homo sapiens 93-97 22864527-8 2013 CLINICAL RELEVANCE: The results of this study suggest the importance of evaluating during bisphosphonate treatment the production of IL-6, RANKL, osteoprotegerin, and VEGF, in order to monitor the jaw osteonecrosis onset. Diphosphonates 90-104 interleukin 6 Homo sapiens 133-137 23396138-8 2013 This regulation of IL-6 by environmental PAHs, that is dependent of inflammatory cytokine microenvironment, may contribute to the well-known carcinogenic properties of these organic pollutants. Polycyclic Aromatic Hydrocarbons 41-45 interleukin 6 Homo sapiens 19-23 22489869-7 2012 Immediate and 1-day postoperative mean serum IL-6 levels were significantly higher in the RA than in the TA group (P=0.023 and 0.044, respectively). Tantalum 105-107 interleukin 6 Homo sapiens 45-49 30843768-6 2020 However, ebselen treatment reduced IL-1beta, IL-6, and IL-8 levels in cells maintained in either 5.5 or 27.5 mM dextrose. ebselen 9-16 interleukin 6 Homo sapiens 45-49 22475649-5 2012 G4-OH and Cel/G4-OH suppressed lipopolysaccharide-mediated release of proinflammatory mediators, such as nitric oxide and IL-6, but not TNF-alpha, without reducing microglial cell viability, while Cel/G4-NH(2) potentiated cytotoxicity and cytokine release. g4-oh 0-5 interleukin 6 Homo sapiens 122-126 22475649-5 2012 G4-OH and Cel/G4-OH suppressed lipopolysaccharide-mediated release of proinflammatory mediators, such as nitric oxide and IL-6, but not TNF-alpha, without reducing microglial cell viability, while Cel/G4-NH(2) potentiated cytotoxicity and cytokine release. g4-oh 14-19 interleukin 6 Homo sapiens 122-126 23513060-4 2013 RESULTS: Exposure to IL-6 at concentrations of 1 and 10 ng/mL and IL-1beta at 10 ng/mL significantly decreased CCh-induced Cl(-) secretion. Carbachol 111-114 interleukin 6 Homo sapiens 21-25 31074089-10 2020 Moreover, nanocurcumin-treated group had high levels of IL-10 and TGF-beta and low levels of IL-6 production than control group. nanocurcumin 10-22 interleukin 6 Homo sapiens 93-97 23593315-5 2013 In vitro, minocycline was found to significantly suppress both constitutive and IL-1beta or 4-hydroxyestradiol (4-OH-E2)-stimulated IL-6 expression in human ovarian cancer cells; OVCAR-3, SKOV-3 and CAOV-3. Minocycline 10-21 interleukin 6 Homo sapiens 132-136 22261616-7 2012 At variance, the PPARalpha agonist Wy14643 promotes MS formation, upregulating NF-kappaB/IL6 axis and MS regulatory genes. pirinixic acid 35-42 interleukin 6 Homo sapiens 89-92 32122859-6 2020 Treatment with increasing concentration of OB (25-200 muM) significantly lowered the cell proliferation rate as well as considerably reduced the values of various pro-inflammatory cytokines like IL-1beta, TNF-alpha, IL-6. obovatol 43-45 interleukin 6 Homo sapiens 216-220 22012204-12 2012 The levels of IL-6 and IL-8 were significantly reduced at 4 weeks after intravitreal MTX, whereas those of vascular endothelial growth factor and monocyte chemotactic protein 1 were not reduced. Methotrexate 85-88 interleukin 6 Homo sapiens 14-18 22012204-14 2012 Intravitreal MTX was associated with a significant reduction of IL-6 and IL-8 levels and was effective and well tolerated even in steroid responders with refractory retinal vasculitis due to Behcet disease. Methotrexate 13-16 interleukin 6 Homo sapiens 64-68 23434371-2 2013 However, here we show that Fas/CD95-induced apoptosis is associated with the production of an array of cytokines and chemokines, including IL-6, IL-8, CXCL1, MCP-1, and GMCSF. ammonium ferrous sulfate 27-30 interleukin 6 Homo sapiens 139-143 31888640-7 2019 RESULTS: Ticagrelor and clopidogrel can inhibit the degradation of IKBalpha and phosphorylation of p65, prevent p65 from entering the nucleus, reduce the production of TNFalpha, IL-1, IL-8, IL-6 and IL-2, and alleviate the decrease in cell viability, cell migration and angiogenesis, the changes of cell cycle and apoptosis induced by LPS. Clopidogrel 24-35 interleukin 6 Homo sapiens 190-194 23220477-6 2013 2) The drug-induced suppression of intramuscular PGE(2) production increased net muscle protein balance after each exercise bout through a reduction in PGE(2)-induced IL-6 and MuRF-1, both promoters of muscle loss. Prostaglandins E 49-52 interleukin 6 Homo sapiens 167-171 23220477-6 2013 2) The drug-induced suppression of intramuscular PGE(2) production increased net muscle protein balance after each exercise bout through a reduction in PGE(2)-induced IL-6 and MuRF-1, both promoters of muscle loss. Prostaglandins E 152-155 interleukin 6 Homo sapiens 167-171 31771617-15 2019 CONCLUSIONS: The DNMT3b plays a critical role in the IL-6-mediated OCT4 expression and the drug sensitivity of sorafenib-resistant HCC. Sorafenib 111-120 interleukin 6 Homo sapiens 53-57 23063726-6 2013 In the presence of BMSCs, Dex plus BTZ combination inhibited ionizing radiation-induced interleukin 6 secretion from BMSCs and induced myeloma cytotoxicity. Bortezomib 35-38 interleukin 6 Homo sapiens 88-101 22726350-3 2012 ST, rosmarinic acid, pulegone, and 2alpha,3alpha,24-thrihydrooxylen-12en-28oic acid treatment of HMC-1 cells led to significant suppression of pro-inflammatory cytokines (IL-6, IL-8, and TNF-alpha) in a dose dependent manner. pulegone 21-29 interleukin 6 Homo sapiens 171-175 31771617-17 2019 Findings from this study highlight the significance of IL-6-DNMT3b-mediated OCT4 expressions in future therapeutic target for patients expressing cancer stemness-related properties or sorafenib resistance in HCC. Sorafenib 184-193 interleukin 6 Homo sapiens 55-59 31871467-9 2019 Global gene expression profiling of BMS-833923-treated compared to vehicle-treated control cells, identified 348 upregulated and 540 downregulated genes with significant effects on multiple signaling pathways, including GPCR, endochondral ossification, RANK-RANKL, insulin, TNF alpha, IL6, and inflammatory response. BMS-833923 36-46 interleukin 6 Homo sapiens 285-288 22555227-1 2012 The aim of this study was to study the effects of rosuvastatin in patients with rheumatoid arthritis (RA) looking at the C-reactive protein (CRP), interleukin-6 (IL-6) and joint disease activity. Rosuvastatin Calcium 50-62 interleukin 6 Homo sapiens 162-166 22555227-9 2012 IL-6 showed a trend towards worsening in the rosuvastatin group (+0.15; SD, 1.09) compared with placebo (-0.73; SD, 1.4); P value, 0.054. Rosuvastatin Calcium 45-57 interleukin 6 Homo sapiens 0-4 22555227-10 2012 These data show that rosuvastatin with might decrease the CRP independent to IL-6 in patients with RA but does not improve the overall rheumatoid disease activity. Rosuvastatin Calcium 21-33 interleukin 6 Homo sapiens 77-81 22313388-0 2012 (-)-Epigallocatechin gallate induces Fas/CD95-mediated apoptosis through inhibiting constitutive and IL-6-induced JAK/STAT3 signaling in head and neck squamous cell carcinoma cells. ammonium ferrous sulfate 37-40 interleukin 6 Homo sapiens 101-105 23470916-2 2013 Several studies indicated that change in the guanine bases to cytosine at position -174 affects the transcription of the IL6 gene, and finally IL6 production level. Cytosine 62-70 interleukin 6 Homo sapiens 121-124 23470916-2 2013 Several studies indicated that change in the guanine bases to cytosine at position -174 affects the transcription of the IL6 gene, and finally IL6 production level. Cytosine 62-70 interleukin 6 Homo sapiens 143-146 31594856-5 2019 However, high amounts of PGE2 and the proinflammatory cytokines IL-1beta and IL-6 were secreted by monocytes activated with MDP in the presence of conditioned medium obtained from CD3 bead-isolated T cells (Tc CM) but not from those isolated without CD3 beads. Contrast Media 207-212 interleukin 6 Homo sapiens 77-81 23268743-5 2013 In the TNF-alpha-induced 3T3-L1 adipocyte model, garcinol and pterostilbene significantly decreased the mRNA expression of COX-2, iNOS, IL-6, and IL-1beta and IL-6 secretion by suppressing phosphorylation of p-IkappaBalpha and p-p65. garcinol 49-57 interleukin 6 Homo sapiens 136-140 23268743-5 2013 In the TNF-alpha-induced 3T3-L1 adipocyte model, garcinol and pterostilbene significantly decreased the mRNA expression of COX-2, iNOS, IL-6, and IL-1beta and IL-6 secretion by suppressing phosphorylation of p-IkappaBalpha and p-p65. garcinol 49-57 interleukin 6 Homo sapiens 159-163 24198583-14 2012 A significant (P < 0.05) elevation of IL-6 was seen immediately post-exercise and 12 hours post-exercise with both the CHO-alone and 4:1 CHO/PRO solutions. cho 122-125 interleukin 6 Homo sapiens 41-45 24198583-14 2012 A significant (P < 0.05) elevation of IL-6 was seen immediately post-exercise and 12 hours post-exercise with both the CHO-alone and 4:1 CHO/PRO solutions. cho 140-143 interleukin 6 Homo sapiens 41-45 31351299-9 2019 Cell-based assays have shown that TBBPA can induce reactive oxygen species in a concentration-dependent manner, and it promotes the production of inflammatory factors such as TNF alpha, IL-6, and IL-8. tetrabromobisphenol A 34-39 interleukin 6 Homo sapiens 186-190 22179221-0 2012 The peroxisome proliferator-activated receptor (PPAR) beta/delta agonist GW501516 inhibits IL-6-induced signal transducer and activator of transcription 3 (STAT3) activation and insulin resistance in human liver cells. GW 501516 73-81 interleukin 6 Homo sapiens 91-95 24378274-11 2013 A time- and dose-dependent upregulation of the expression of IL-6 and IL-8 mRNA was observed during the treatment at 3 and 24 h. In contrast, TNF-alpha mRNA expression was highly upregulated at 3 h after FFA exposure but returned to control values at 24 h. In conclusion, hepatocytes exposed in vitro for a short time to low FFA concentrations showed a significant upregulation of IL-6 and IL-8 to,and a rapid but transitory elevation of TNF-alpha. Fatty Acids, Nonesterified 204-207 interleukin 6 Homo sapiens 61-65 24378274-11 2013 A time- and dose-dependent upregulation of the expression of IL-6 and IL-8 mRNA was observed during the treatment at 3 and 24 h. In contrast, TNF-alpha mRNA expression was highly upregulated at 3 h after FFA exposure but returned to control values at 24 h. In conclusion, hepatocytes exposed in vitro for a short time to low FFA concentrations showed a significant upregulation of IL-6 and IL-8 to,and a rapid but transitory elevation of TNF-alpha. Fatty Acids, Nonesterified 325-328 interleukin 6 Homo sapiens 61-65 31276896-4 2019 Furthermore, the amine 4c, naphthoquinone 5, and azo-based 13 and 15 organic selenides were able to down-regulate the expression of Bcl-2 and up-regulate the expression levels of IL-2, IL-6 and CD40 in HepG2 cells compared to untreated cells. Amines 17-22 interleukin 6 Homo sapiens 185-189 23228258-9 2013 Levels of proinflammatory cytokines (eg, interleukin 6, interleukin 8, and matrix metalloproteinase-3 [MMP3]) were increased by CQ treatment. camphorquinone 128-130 interleukin 6 Homo sapiens 41-54 22301548-5 2012 We observed that two forms of the vitamin D, 1,25(OH)(2)D(3), and 25(OH)D(3), dose dependently inhibited LPS-induced p38 phosphorylation at physiologic concentrations, IL-6 and TNF-alpha production by human monocytes. Deuterium 42-43 interleukin 6 Homo sapiens 168-172 31327593-5 2019 CSF IL-6 levels were associated with the infiltration rate of TAMs in GBMs, and IL-6 levels were increased in the GBM cells co-cultured with TAM-like macrophages. tam 62-65 interleukin 6 Homo sapiens 4-8 23218935-0 2013 Postoperative subcutaneous instillation of low-dose ketorolac but not hydromorphone reduces wound exudate concentrations of interleukin-6 and interleukin-10 and improves analgesia following cesarean delivery. Ketorolac 52-61 interleukin 6 Homo sapiens 124-137 31338984-5 2019 It is demonstrated that the loss of function of miR-369-3p in LPS-stimulated DCs during quercetin exposure led to an increase of CCAAT/enhancer binding protein beta (C/EBP-beta) mRNA and protein and its downstream targets tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL6). Quercetin 88-97 interleukin 6 Homo sapiens 266-279 23218935-5 2013 The addition of ketorolac to bupivacaine significantly decreased IL-6 (P = .012) and IL-10 (P = .005) compared to plain bupivacaine. Ketorolac 16-25 interleukin 6 Homo sapiens 65-69 21854184-0 2012 Combination of midazolam and a cyclooxygenase-2 inhibitor inhibits lipopolysaccharide-induced interleukin-6 production in human peripheral blood mononuclear cells. Midazolam 15-24 interleukin 6 Homo sapiens 94-107 21854184-2 2012 Midazolam has been reported to modulate IL-6 response. Midazolam 0-9 interleukin 6 Homo sapiens 40-44 21854184-5 2012 OBJECTIVE: The aim of the present study was to evaluate the effect of the combination of midazolam and a COX inhibitor on IL-6 production. Midazolam 89-98 interleukin 6 Homo sapiens 122-126 31338984-5 2019 It is demonstrated that the loss of function of miR-369-3p in LPS-stimulated DCs during quercetin exposure led to an increase of CCAAT/enhancer binding protein beta (C/EBP-beta) mRNA and protein and its downstream targets tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL6). Quercetin 88-97 interleukin 6 Homo sapiens 281-284 21854184-11 2012 DISSCUSSION AND CONCLUSION: The results in the present study demonstrated that the combination of midazolam and a COX-2 inhibitor inhibited LPS-induced IL-6 production in human PBMCs even if each drug separately did not have any effect on it. Midazolam 98-107 interleukin 6 Homo sapiens 152-156 21854184-12 2012 The finding suggests that their combination is effective against excessive IL-6 production such as severe inflammatory response and that the effect of midazolam on IL-6 production is possibly elicited via 15dPGJ2. Midazolam 151-160 interleukin 6 Homo sapiens 164-168 23533581-5 2013 DNA-PKcs-deficient DCs exhibited a defect in the IL-6 and IL-12 response to CpG-ODN in a dose- and time-dependent manner. CPG-oligonucleotide 76-83 interleukin 6 Homo sapiens 49-53 31431121-8 2019 Consistently, in patients with MS, a negative correlation emerged between IL-6 CSF concentrations and the effect of PAS. Aminosalicylic Acid 116-119 interleukin 6 Homo sapiens 74-78 23874021-5 2013 CIRT is based, in part, on observational evidence of reduced vascular event rates among those treated with methotrexate in the setting of rheumatoid arthritis or psoriatic arthritis and on the ability of methotrexate to reduce TNF, IL-6, and CRP levels. cirt 0-4 interleukin 6 Homo sapiens 232-236 23874021-5 2013 CIRT is based, in part, on observational evidence of reduced vascular event rates among those treated with methotrexate in the setting of rheumatoid arthritis or psoriatic arthritis and on the ability of methotrexate to reduce TNF, IL-6, and CRP levels. Methotrexate 107-119 interleukin 6 Homo sapiens 232-236 23874021-5 2013 CIRT is based, in part, on observational evidence of reduced vascular event rates among those treated with methotrexate in the setting of rheumatoid arthritis or psoriatic arthritis and on the ability of methotrexate to reduce TNF, IL-6, and CRP levels. Methotrexate 204-216 interleukin 6 Homo sapiens 232-236 22269218-8 2012 CONCLUSIONS: Gamma tocopherol supplementation increased IL-6, IL-8, and KDR mRNA abundances and suppressed sFlt1 and TNFalpha mRNA abundances thereby increased VEGF mRNA expression and angiogenesis in placental vascular network during late gestation. Tocopherols 19-29 interleukin 6 Homo sapiens 56-60 31547402-0 2019 Quercetin Interrupts the Positive Feedback Loop Between STAT3 and IL-6, Promotes Autophagy, and Reduces ROS, Preventing EBV-Driven B Cell Immortalization. Quercetin 0-9 interleukin 6 Homo sapiens 66-70 22363103-0 2012 Low dose theophylline showed an inhibitory effect on the production of IL-6 and IL-8 in primary lung fibroblast from patients with COPD. Theophylline 9-21 interleukin 6 Homo sapiens 71-75 22363103-6 2012 For COPD fibroblasts, the protein levels of IL-6 and IL-8 decreased from 993.0 +- 738.9 pg/mL to 650.1 +- 421.9 pg/mL (P = 0.014) and from 703.1 +- 278.0 pg/mL to 492.0 +- 214.9 pg/mL (P = 0.001), respectively, with 5 mug/mL theophylline treatment. Theophylline 225-237 interleukin 6 Homo sapiens 44-48 22363103-7 2012 In addition, theophylline at the dose of 5 mug/mL reduced the increased production of IL-6 and IL-8 induced by 1 mug/mL LPS in primary human lung fibroblasts. Theophylline 13-25 interleukin 6 Homo sapiens 86-90 23344020-6 2012 Oenothein B also markedly suppressed the production of inflammatory cytokines, such as IL-1beta and IL-6, in a dose-dependent manner. oenothein B 0-11 interleukin 6 Homo sapiens 100-104 31547402-3 2019 The results obtained indicated that quercetin inhibited thectivation of signal transducer and activator of transcription 3 (STAT3) induced by EBV infection and reduced molecules such as interleukin-6 (IL-6) and reactive oxidative species (ROS) known to be essential for the immortalization process. Quercetin 36-45 interleukin 6 Homo sapiens 186-199 31547402-3 2019 The results obtained indicated that quercetin inhibited thectivation of signal transducer and activator of transcription 3 (STAT3) induced by EBV infection and reduced molecules such as interleukin-6 (IL-6) and reactive oxidative species (ROS) known to be essential for the immortalization process. Quercetin 36-45 interleukin 6 Homo sapiens 201-205 22347616-7 2012 In analyses controlling for other important dietary and lifestyle factors, IL-6 and TNF-alpha were significantly lower across categories of increasing F&V intakes (p < 0.008). f& 151-156 interleukin 6 Homo sapiens 75-79 31491838-10 2019 Taken together, our findings identify IL-6Ralpha as a direct target of MH and its flavonoids, highlighting IL-6R blockade as a mechanism for the anti-tumor activity of MH, as well as a viable therapeutic target in IL-6-dependent cancers. Flavonoids 82-92 interleukin 6 Homo sapiens 38-42 23251686-0 2012 Synergistic cooperation between methamphetamine and HIV-1 gsp120 through the P13K/Akt pathway induces IL-6 but not IL-8 expression in astrocytes. gsp120 58-64 interleukin 6 Homo sapiens 102-106 24293976-3 2012 We tested the hypothesis that some of the beneficial effect of clopidogrel may be due to the variable activity of this drug on the vascular system (assessed by plasma markers von Willebrand factor and soluble E-selectin, and functional arterial pulse wave velocity) and inflammation (C-reactive protein and interleukin-6) while 32 patients with coronary artery disease taking 75 mg clopidogrel daily, and again 2 weeks after cessation of clopidogrel therapy. Clopidogrel 63-74 interleukin 6 Homo sapiens 307-320 23285694-7 2012 GHK and their copper complexes and saccharomyces/copper ferment (Oligolides Copper) on secretion of pro-inflammatory IL-6 in normal human dermal fibroblasts NHDF cell line. oligolides 65-75 interleukin 6 Homo sapiens 117-121 22802109-6 2012 RESULTS: Combined administration of ETN/MTX significantly inhibited the proliferation of T lymphocytes, decreased serum IL-6, TNF-alpha, IL-1beta, RANKL and macrophage supernatant IL-17, LT-alpha, increased serum IFN-gamma and macrophage supernatant IL-10. Methotrexate 40-43 interleukin 6 Homo sapiens 120-124 22916253-11 2012 Moreover, we found that both LPS and CpG oligodeoxynucleotides (ODN) induced robust pro-inflammatory responses in thrombocytes, as characterized by more than 100 fold increase in interleukin (IL)-1beta, IL-6 and IL-8 transcripts, while only LPS enhanced nitric oxide production and phagocytic capabilities. CPG-oligonucleotide 37-62 interleukin 6 Homo sapiens 203-207 31229737-5 2019 RESULTS: Here, Pam3C (TLR2) and LPS (TLR4) induced significant cell proliferation and IL-6, IL-17 and IL-21 production by CD4+ T-cells from NMOSD. pam3c 15-20 interleukin 6 Homo sapiens 86-90 21924767-7 2011 Compared with naked Ad, systemic administration of ABP-conjugated Ad resulted in reduced liver toxicity and interleukin (IL)-6 production in vitro and in vivo. abp 51-54 interleukin 6 Homo sapiens 108-126 22982675-2 2012 In this study, we show that withaferin A inhibits constitutive and IL-6-induced phosphorylation of STAT3 (on Tyr705), but not IFN-gamma-induced STAT1 phosphorylation. withaferin A 28-40 interleukin 6 Homo sapiens 67-71 31229737-8 2019 Finally, circulating levels of CD14, an indirect marker of microbial translocation, were positively correlated with IL-6, IL-17 and IL-21 release by Pam3C- and LPS-activated CD4+ T-cells. pam3c 149-154 interleukin 6 Homo sapiens 116-120 31920220-7 2019 Those who received IPSRT+quetiapine had significantly greater increases in IL-6 (p=0.02) and TNF-alpha (p=0.04), even after adjusting for changes in body mass index, than the IPSRT alone group. ipsrt 19-24 interleukin 6 Homo sapiens 75-79 22609260-0 2012 Serum interleukin-6 levels in response to methotrexate treatment in psoriatic patients. Methotrexate 42-54 interleukin 6 Homo sapiens 6-19 22609260-4 2012 The aim of this study is to assess the effect of MTX on serum IL-6 levels and also to find the association between PASI score and IL-6 levels in psoriatic patients during MTX therapy. Methotrexate 49-52 interleukin 6 Homo sapiens 62-66 22609260-4 2012 The aim of this study is to assess the effect of MTX on serum IL-6 levels and also to find the association between PASI score and IL-6 levels in psoriatic patients during MTX therapy. Methotrexate 171-174 interleukin 6 Homo sapiens 130-134 22609260-13 2012 Serum IL-6 level and PASI score declined significantly (p<0.001) from Day 0 to 12 weeks of MTX treatment and also showed positive correlation before (r=0.992; p<0.000) and after (r=0.987; p<0.000) treatment with MTX. Methotrexate 94-97 interleukin 6 Homo sapiens 6-10 22609260-13 2012 Serum IL-6 level and PASI score declined significantly (p<0.001) from Day 0 to 12 weeks of MTX treatment and also showed positive correlation before (r=0.992; p<0.000) and after (r=0.987; p<0.000) treatment with MTX. Methotrexate 221-224 interleukin 6 Homo sapiens 6-10 21234673-9 2011 These functional alterations were driven by elevated cAMP, as direct activation of adenylate cyclase by forskolin elicited similar alterations in VEGF and IL-6 production. Colforsin 104-113 interleukin 6 Homo sapiens 155-159 31920220-7 2019 Those who received IPSRT+quetiapine had significantly greater increases in IL-6 (p=0.02) and TNF-alpha (p=0.04), even after adjusting for changes in body mass index, than the IPSRT alone group. Quetiapine Fumarate 25-35 interleukin 6 Homo sapiens 75-79 22133036-3 2011 MTX reduces the production of pro-inflammatory cytokines such as interleukin (IL)-1, IL-2, IL-6 and interferon (INF)-gamma, while the gene expression of anti-inflammatory Th2 cytokines like IL-4 and IL-10 is increased - altogether resulting in the anti-inflammatory effect. Methotrexate 0-3 interleukin 6 Homo sapiens 91-95 22133036-10 2011 Consistent with other reports, IL-6 was reduced under MTX treatment. Methotrexate 54-57 interleukin 6 Homo sapiens 31-35 30542936-10 2019 Additionally, before sleep nNO was also positively associated with IL-6 (r = 0.586, p = 0.005) and IL-8 (r = 0.520, p = 0.016) concentration. Nitrous Oxide 27-30 interleukin 6 Homo sapiens 67-71 21636248-6 2011 The inborn or acquired deficiencies of IL-6, TNF-alpha and TNF receptor functions are associated with the lowest EAMG incidences. eamg 113-117 interleukin 6 Homo sapiens 39-43 23046548-8 2012 Unopsonized IE induced secretion of IL-6 (median= 622 pg/ml [IQR=1,250-240], n=9) but no IL-1beta or TNF, whereas PPS-opsonized IE induced secretion of IL-1beta (18.6 pg/mL [34.2-14.4]) and TNF (113 pg/ml [421-17.0]) and increased IL-6 secretion (2,195 pg/ml [4,658-1,095]). pps 114-117 interleukin 6 Homo sapiens 231-235 31531360-8 2019 Our results demonstrated that quercetin inhibited the LPS-induced production of IL-1beta, IL-6, IL-8, and TNF-alpha in a dose-dependent manner. Quercetin 30-39 interleukin 6 Homo sapiens 90-94 23006534-9 2012 RESULTS: Incubation with LPS, LTA or TCS significantly increased TNF-alpha, IL-1beta, IL-6, IL-8, IFN-gamma and IL-2 in comparison to incubation with RPMI alone. lipoteichoic acid 30-33 interleukin 6 Homo sapiens 86-90 21732177-5 2011 We found that cells treated with IL-6 displayed fewer lipids and an elevated glycerol release rate. Glycerol 77-85 interleukin 6 Homo sapiens 33-37 31531360-11 2019 In conclusion, these results suggested that quercetin attenuated the production of IL-1beta, IL-6, IL-8, and TNF-alpha in P. gingivalis LPS-treated HGFs by activating PPAR-gamma which subsequently suppressed the activation of NF-kappaB. Quercetin 44-53 interleukin 6 Homo sapiens 93-97 21555360-7 2011 Finally, we have shown that lipoxin A(4) can suppress phorbol myristate acetate-induced expression of the inflammatory cytokines interleukin 6 and 8 in human endometrium and decidua tissue. lipoxin A4 28-37 interleukin 6 Homo sapiens 129-148 31412584-3 2019 Docetaxel or vinorelbine inhibits proliferation and stimulates the differentiation of breast preadipocytes, by increasing C/EBPalpha and PPARgamma expression and by downregulating tumor necrosis factor alpha (TNFalpha), interleukin 6 (IL-6), and IL-11 expression. Docetaxel 0-9 interleukin 6 Homo sapiens 220-233 23105953-0 2012 Minocycline prevents IL-6 increase after acute ischemic stroke. Minocycline 0-11 interleukin 6 Homo sapiens 21-25 23105953-2 2012 Minocycline (MC) is a known anti-inflammatory agent; thus, the effect of MC on IL-6 in the first 24 h of AIS was investigated to determine potential anti-inflammatory activity. Minocycline 73-75 interleukin 6 Homo sapiens 79-83 22941473-4 2012 Additionally, CX-4945 reduces angiogenesis via blockade of hypoxia-inducible factor-1alpha transcription and suppresses the inflammatory interleukin-6 production in human breast cancer cells. silmitasertib 14-21 interleukin 6 Homo sapiens 137-150 31412584-3 2019 Docetaxel or vinorelbine inhibits proliferation and stimulates the differentiation of breast preadipocytes, by increasing C/EBPalpha and PPARgamma expression and by downregulating tumor necrosis factor alpha (TNFalpha), interleukin 6 (IL-6), and IL-11 expression. Docetaxel 0-9 interleukin 6 Homo sapiens 235-239 20870897-3 2011 Troglitazone dose-dependently reduced the IL-1beta-induced release of IL-6 and vascular endothelial growth factor, the TNF-alpha-induced release of eotaxin and regulated on activation, normal T expressed and secreted (RANTES), and the IL-4-induced release of eotaxin. Troglitazone 0-12 interleukin 6 Homo sapiens 70-74 31412584-3 2019 Docetaxel or vinorelbine inhibits proliferation and stimulates the differentiation of breast preadipocytes, by increasing C/EBPalpha and PPARgamma expression and by downregulating tumor necrosis factor alpha (TNFalpha), interleukin 6 (IL-6), and IL-11 expression. Vinorelbine 13-24 interleukin 6 Homo sapiens 220-233 31412584-3 2019 Docetaxel or vinorelbine inhibits proliferation and stimulates the differentiation of breast preadipocytes, by increasing C/EBPalpha and PPARgamma expression and by downregulating tumor necrosis factor alpha (TNFalpha), interleukin 6 (IL-6), and IL-11 expression. Vinorelbine 13-24 interleukin 6 Homo sapiens 235-239 31042404-5 2019 NHERF1 knockdown fully abrogated the ISO-, PGE2-, and FSK-induced IL-6 gene expression and cytokine production without affecting cAMP-mediated phosphodiesterase 4D (PDE4D) gene expression, phospho-cAMP response element-binding protein (p-CREB), and cAMP response element (CRE)-Luc, or PDGF-induced cyclin D1 expression. Colforsin 54-57 interleukin 6 Homo sapiens 66-70 21051589-4 2011 (3)H-thymidine incorporation assays revealed that IL-6 treatment inhibited the proliferation of LNCaP cells. h-thymidine 3-14 interleukin 6 Homo sapiens 50-54 21605007-7 2011 In contrast, the non-purine metabolite taurine correlated with baseline neutrophil counts (r = 0.56) and IL-6 (r = 0.53) and was elevated post-exposure in both atopic cohorts. purine 21-27 interleukin 6 Homo sapiens 105-109 22661653-8 2012 Quercetin reduced IL-6, IL-8 and TNFalpha protein production in supernatants of all GO samples (n=4) in a dose-dependent manner; however, only the reduction in IL-6 was statistically significant (p<0.05). Quercetin 0-9 interleukin 6 Homo sapiens 18-22 22661653-8 2012 Quercetin reduced IL-6, IL-8 and TNFalpha protein production in supernatants of all GO samples (n=4) in a dose-dependent manner; however, only the reduction in IL-6 was statistically significant (p<0.05). Quercetin 0-9 interleukin 6 Homo sapiens 160-164 22661653-9 2012 Quercetin had a significant suppression of tissue IL-6, IL-8, IL-1beta and TNFalpha mRNA expression in cultured orbital tissues from three GO samples relative to untreated control tissue (p<0.05). Quercetin 0-9 interleukin 6 Homo sapiens 50-54 22592163-3 2012 This study focused on the ability of these alkaloids to modulate the gene expression of pro-inflammatory tumour necrosis factor alpha (TNF-alpha), monocyte chemoattractant protein 1 (MCP-1, also known as CCL-2), interleukin (IL)-6, IL-1beta and anti-inflammatory cytokines IL-1 receptor antagonist (IL-1RA) and IL-10. Alkaloids 43-52 interleukin 6 Homo sapiens 212-230 31337739-6 2019 In a coculture system, adipocytes secreted the cytokines IL-6 and TNF-alpha, which induced a proliferative-to-invasive phenotypic switch in melanoma cells by repressing the expression of the microRNA miR-211. mir-211 200-207 interleukin 6 Homo sapiens 57-61 22445541-0 2012 Lipoteichoic acid of Staphylococcus aureus enhances IL-6 expression in activated human basophils. lipoteichoic acid 0-17 interleukin 6 Homo sapiens 52-56 22445541-8 2012 Collectively, these results suggest that Sa.LTA exacerbates allergic inflammation by potentiating IL-6 production from activated basophils. lipoteichoic acid 44-47 interleukin 6 Homo sapiens 98-102 22538414-0 2012 Amphotericin B up-regulates lipid A-induced IL-6 production via caspase-8. Lipid A 28-35 interleukin 6 Homo sapiens 44-48 21190890-7 2011 CONCLUSIONS: Two week senofilcon A daily CL wear seems to be associated with tear instability, a decrease in MUC5AC expression, and elevation of IL-6 in tears without significant alterations in epithelial damage scores or in the morphology or density of in vivo keratoconjunctival cells and nerves. senofilcon A 22-34 interleukin 6 Homo sapiens 145-149 31456826-5 2019 SP600125 inhibited significantly IL-6 mRNA transcription in the high responder group and did not influence the transcription level in the low responder group. pyrazolanthrone 0-8 interleukin 6 Homo sapiens 33-37 21524164-5 2011 In addition to revealing a new tumor-escape mechanism associated with TAM generation via leukemia-inhibitory factor and IL-6, these findings offer novel therapeutic perspectives to subvert TAM-induced immunosuppression and to improve antitumor immunotherapy efficacy. tam 70-73 interleukin 6 Homo sapiens 120-124 21241278-2 2011 We therefore sought to determine whether the IL-6-neutralizing monoclonal antibody siltuximab, formerly CNTO 328, could enhance the activity of melphalan, and to examine some of the mechanisms underlying this interaction. Melphalan 144-153 interleukin 6 Homo sapiens 45-49 22538414-4 2012 However, amphotericin B synergistically up-regulated lipid A-induced production of IL-6 and IL-8. Lipid A 53-60 interleukin 6 Homo sapiens 83-87 22538414-9 2012 In addition, a caspase-8 inhibitor inhibited IL-6 production by amphotericin B and lipid A. Lipid A 83-90 interleukin 6 Homo sapiens 45-49 22538414-10 2012 This suggests that caspase-8 is required for the synergistic production of IL-6 by amphotericin B and lipid A. Lipid A 102-109 interleukin 6 Homo sapiens 75-79 31258638-0 2019 Clinical efficacy of gangliosides on premature infants suffering from white matter damage and its effect on the levels of IL-6, NSE and S100beta. Gangliosides 21-33 interleukin 6 Homo sapiens 122-126 22966500-14 2012 The results indicate a suppression of inflammatory cytokine release, in particular IL-6, in patients treated with high-dose MgSO(4). mgso 124-128 interleukin 6 Homo sapiens 83-87 21282043-9 2011 Consequently, quercetin suppressed UV irradiation-induced expression of inflammatory cytokines IL-1beta (~60%), IL-6 (~80%), IL-8 (~76%) and TNF-alpha (~69%). Quercetin 14-23 interleukin 6 Homo sapiens 112-116 31258638-1 2019 This study investigated the clinical efficacy of gangliosides on premature infants suffering from white matter damage and its effect on the levels of IL-6, neuron-specific enolase (NSE) and S100beta. Gangliosides 49-61 interleukin 6 Homo sapiens 150-154 22421411-0 2012 Interleukin-6, osteopontin and Raf/MEK/ERK signaling modulate the sensitivity of human myeloma cells to alkylphosphocholines. alkylphosphocholines 104-124 interleukin 6 Homo sapiens 0-13 31212975-11 2019 Taken together, these results provide evidence that quercetin protects ARPE-19 cells from the IL-1beta-stimulated increase in ICAM-1, sICAM-1, IL-6, IL-8 and MCP-1 production by blocking the activation of MAPK and NF-kappaB signaling pathways to ameliorate the inflammatory response. Quercetin 52-61 interleukin 6 Homo sapiens 143-147 21131394-10 2011 The changes in oxidant/antioxidant enzymes and IL-6 release were reversed by the antioxidants N-acetyl-cysteine (NAC) and ebselen through inhibition of Smad3 phosphorylation, indicating redox-dependent activation of Smad3 by TGF-beta. ebselen 122-129 interleukin 6 Homo sapiens 47-51 30360657-5 2019 RESULTS: The halogen light group showed significantly more DNA damage, higher TNF-alpha, IL-1beta, and IL-6 levels, and lower viable cell count at 30 min compared to the control group. Halogens 13-20 interleukin 6 Homo sapiens 103-107 21095135-7 2011 CHO ingestion significantly reduced post-exercise IL-6 (p<.05) but this had no effect on plasma hepcidin or iron concentration. cho 0-3 interleukin 6 Homo sapiens 50-54 21186817-4 2011 The results showed that p-coumaric acid, quercetin, and resveratrol have greater inhibition (p < 0.05) of a TNF-alpha-induced increase in the production of interleukin-6 (IL-6) among 21 tested polyphenolic compounds. p-coumaric acid 24-39 interleukin 6 Homo sapiens 159-172 21186817-4 2011 The results showed that p-coumaric acid, quercetin, and resveratrol have greater inhibition (p < 0.05) of a TNF-alpha-induced increase in the production of interleukin-6 (IL-6) among 21 tested polyphenolic compounds. p-coumaric acid 24-39 interleukin 6 Homo sapiens 174-178 21186817-4 2011 The results showed that p-coumaric acid, quercetin, and resveratrol have greater inhibition (p < 0.05) of a TNF-alpha-induced increase in the production of interleukin-6 (IL-6) among 21 tested polyphenolic compounds. Quercetin 41-50 interleukin 6 Homo sapiens 159-172 21186817-4 2011 The results showed that p-coumaric acid, quercetin, and resveratrol have greater inhibition (p < 0.05) of a TNF-alpha-induced increase in the production of interleukin-6 (IL-6) among 21 tested polyphenolic compounds. Quercetin 41-50 interleukin 6 Homo sapiens 174-178 22406995-0 2012 Sorafenib inhibits endogenous and IL-6/S1P induced JAK2-STAT3 signaling in human neuroblastoma, associated with growth suppression and apoptosis. Sorafenib 0-9 interleukin 6 Homo sapiens 34-38 22406995-7 2012 Sorafenib also inhibited the phosphorylation of STAT3 induced by IL-6 and sphingosine-1-phosphate (S1P), a recently identified regulator for STAT3, in these tumor cells. Sorafenib 0-9 interleukin 6 Homo sapiens 65-69 22356805-0 2012 Melphalan exposure induces an interleukin-6 deficit in bone marrow stromal cells and osteoblasts. Melphalan 0-9 interleukin 6 Homo sapiens 30-43 22356805-8 2012 Decreased IL-6 protein is the most pronounced following melphalan exposure compared to several other chemotherapeutic agents tested. Melphalan 56-65 interleukin 6 Homo sapiens 10-14 30835936-6 2019 Finally, for verifying the accuracy of microarray analysis, qRT-PCR was used to analyze the transcription level of key genes in the above signaling pathways, and ELISA assay confirmed the effect of TBBPA on the levels of CXCL-2, CCL-3, CCL-4, IL-1beta, TNF-alpha, and IL-6. tetrabromobisphenol A 198-203 interleukin 6 Homo sapiens 268-272 22356805-9 2012 We also observed that melphalan decreased IL-6 mRNA in both BMSC and HOB. Melphalan 22-31 interleukin 6 Homo sapiens 42-46 22356805-10 2012 Finally, using a model of BMSC or HOB co-cultured with myeloma cells exposed to melphalan, we observed that IL-6 protein was also decreased, consistent with treatment of adherent cells alone. Melphalan 80-89 interleukin 6 Homo sapiens 108-112 21232138-8 2011 In addition, alpha-TEA induced higher levels of the inflammatory cytokine IL-6 and the chemokine CCL5. 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid 13-22 interleukin 6 Homo sapiens 74-78 31138333-7 2019 TAM generated in vitro exhibited increased transcript levels of the functional markers IL-6, IL-10, CCL2, c-Myc, iNOS, and arginase compared to in vitro generated M2-like macrophages. tam 0-3 interleukin 6 Homo sapiens 87-91 21879468-9 2011 Levels of serum IL-6 values were significantly elevated in PostTx: 3.0 (2.14-6.40) and MTx: 2.24 (1.60-5.10), compared to PremTx females: 1.39 (0.96-2.14) (p < 0.01 and p < 0.05 respectively). Methotrexate 87-90 interleukin 6 Homo sapiens 16-20 22394507-0 2012 Quercetin abrogates IL-6/STAT3 signaling and inhibits glioblastoma cell line growth and migration. Quercetin 0-9 interleukin 6 Homo sapiens 20-24 22394507-5 2012 In this study, we show that quercetin is a potent inhibitor of the IL-6-induced STAT3 signaling pathway in T98G and U87 glioblastoma cells. Quercetin 28-37 interleukin 6 Homo sapiens 67-71 22394507-6 2012 Exposure to quercetin resulted in the reduction of GP130, JAK1 and STAT3 activation by IL-6, as well as a marked decrease of the proliferative and migratory properties of glioblastoma cells induced by IL-6. Quercetin 12-21 interleukin 6 Homo sapiens 87-91 22394507-6 2012 Exposure to quercetin resulted in the reduction of GP130, JAK1 and STAT3 activation by IL-6, as well as a marked decrease of the proliferative and migratory properties of glioblastoma cells induced by IL-6. Quercetin 12-21 interleukin 6 Homo sapiens 201-205 31164826-13 2019 DNJ significantly reduced the levels of hs-CRP, IL-6, TNF-a, MDA, SAS, HAMD, AP, and BSS scores and increased SOD level (p < 0.05). 1-Deoxynojirimycin 0-3 interleukin 6 Homo sapiens 48-52 22394507-8 2012 Moreover, quercetin reduced the recruitment of STAT3 at the cyclin D1 promoter and inhibited Rb phosphorylation in the presence of IL-6. Quercetin 10-19 interleukin 6 Homo sapiens 131-135 22394507-9 2012 Overall, these results provide new insight into the role of quercetin as a blocker of the STAT3 activation pathway stimulated by IL-6, with a potential role in the prevention and treatment of glioblastoma. Quercetin 60-69 interleukin 6 Homo sapiens 129-133 21108840-7 2010 CYT and quercetin, an active compound of CYT, significantly inhibited LPS-induced interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha production and expression in PBMCs. Quercetin 8-17 interleukin 6 Homo sapiens 106-110 21054880-5 2010 We have examined whether saturated nonesterified fatty acids (NEFA) and insulin, which increase in concentration with developing insulin resistance, can trigger the production of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha in human monocytes. Fatty Acids, Nonesterified 62-66 interleukin 6 Homo sapiens 179-197 30648905-5 2019 In both cell types, challenge with arachidonic acid (AA) (omega-6 PUFA) and poly(I:C) or LTA led to substantially greater IL-6 and CXCL8 release than either challenge alone, demonstrating synergy. omega-6 pufa 58-70 interleukin 6 Homo sapiens 122-126 19847432-10 2010 In conclusion, adalimumab and MTX treatment down regulates peripheral Th17 cells and serum IL-6 level in RA patients. Methotrexate 30-33 interleukin 6 Homo sapiens 91-95 22294644-0 2012 Plasma IL-6 and IL-9 predict the failure of interferon-alpha plus ribavirin therapy in HIV/HCV-coinfected patients. Ribavirin 66-75 interleukin 6 Homo sapiens 7-11 22284606-6 2012 We report here a case of effective interleukin-6 blocker in the treatment of refractory giant cell arteritis with ileitis and high-dose steroid dependence despite 2 years of treatment with steroids and methotrexate. Methotrexate 202-214 interleukin 6 Homo sapiens 35-48 30586620-4 2019 The clinical signs of CRS correlate with T cell activation and high levels of cytokines including IL-6. 3-cresol 22-25 interleukin 6 Homo sapiens 98-102 22555227-1 2012 The aim of this study was to study the effects of rosuvastatin in patients with rheumatoid arthritis (RA) looking at the C-reactive protein (CRP), interleukin-6 (IL-6) and joint disease activity. Rosuvastatin Calcium 50-62 interleukin 6 Homo sapiens 147-160 20878012-5 2010 Our aim was to assess the functional changes of mDC and pDC harvested from an amoxicillin-hypersensitive 32-year-old woman who experienced a severe maculopapular exanthema as reflected in interleukin-6 (IL-6) production after stimulation with this drug and penicillin. Amoxicillin 78-89 interleukin 6 Homo sapiens 188-201 20878012-5 2010 Our aim was to assess the functional changes of mDC and pDC harvested from an amoxicillin-hypersensitive 32-year-old woman who experienced a severe maculopapular exanthema as reflected in interleukin-6 (IL-6) production after stimulation with this drug and penicillin. Amoxicillin 78-89 interleukin 6 Homo sapiens 203-207 20878012-10 2010 A positive dose-response curve for IL-6 after stimulation with amoxicillin and penicillin was observed for pDC, but not for mDC or BDC suspension. Amoxicillin 63-74 interleukin 6 Homo sapiens 35-39 30631154-3 2019 Mechanistically, high glucose, TGF-beta, CTGF, SHH, and IL-6 induce the expression of a long non-coding RNA, GAEA (Glucose Aroused for EMT Activation), which associates with an RNA-binding E3 ligase, MEX3C, and enhances its enzymatic activity, leading to the K27-linked polyubiquitination of PTEN. gaea 109-113 interleukin 6 Homo sapiens 56-60 20878012-10 2010 A positive dose-response curve for IL-6 after stimulation with amoxicillin and penicillin was observed for pDC, but not for mDC or BDC suspension. Penicillins 79-89 interleukin 6 Homo sapiens 35-39 20379953-0 2010 Kansuinine A and Kansuinine B from Euphorbia kansui L. inhibit IL-6-induced Stat3 activation. Kansuinine B 17-29 interleukin 6 Homo sapiens 63-67 20663885-7 2010 Forskolin also stimulated expression of interleukin-6 but not osteoprotegerin (OPG), an inhibitor of RANKL. Colforsin 0-9 interleukin 6 Homo sapiens 40-53 22045303-3 2012 The aim of this study was to evaluate the effects of one of the most widespread mycotoxin, ochratoxin A (OTA), on the release of pro-inflammatory cytokines such as interleukin-(IL)-6 and the CXC-chemokine IL-8 from nasal epithelial cell cultures (NEC) of subjects with and without ECRS. ochratoxin A 91-103 interleukin 6 Homo sapiens 164-182 30502207-2 2019 By this means, flavonoids displayed significant antioxidant activity by donating electron, H atom as well as capturing DPPH and ABTS+ free radicals, and anti-inflammatory effect by inhibiting the production of the inflammatory mediators (NO radicals, PGE2 and TNF-alpha) and pro-inflammatory cytokines (IL-1beta and IL-6). Flavonoids 15-25 interleukin 6 Homo sapiens 316-320 22487368-5 2012 Quercetin, one of the active components in Calendula, has been shown to inhibit recombinant human matrix metalloproteinase (MMP) activity and decrease the expression of tumor necrosis factor-alpha, interleukin-1beta (IL), IL-6 and IL-8 in phorbol 12-myristate 13-acetate and calcium ionophore-stimulated human mast cells. Quercetin 0-9 interleukin 6 Homo sapiens 222-226 22179221-9 2012 CONCLUSIONS/INTERPRETATION: Overall, our findings show that the PPARbeta/delta activator GW501516 prevents IL-6-induced STAT3 activation by inhibiting ERK1/2 phosphorylation and preventing the reduction in phospho-AMPK levels. GW 501516 89-97 interleukin 6 Homo sapiens 107-111 20694980-4 2010 The amount of cytokine IL-6 secreted by macrophages did not depend on the dose of BCBs but macrophages secreted more TNF-alpha in response to higher doses of BCBs. bcbs 158-162 interleukin 6 Homo sapiens 23-27 30354488-4 2019 The p65 subunit of NF-kappaB was translocated into the nucleus of the cells treated with 100 microg mL-1 PM2.5 at 6 and 24 h. Bay11-7082 partly inhibited PM2.5-induced increases of IL-6 and IL-8 secretion. 3-(4-methylphenylsulfonyl)-2-propenenitrile 126-136 interleukin 6 Homo sapiens 181-185 20381376-10 2010 CONCLUSIONS: DCA is related to increased serum IL-6 levels but does not cause clinical SIRS. dichloroacetylene 13-16 interleukin 6 Homo sapiens 47-51 20451499-4 2010 Thrombin activated Akt, PKC and MAPK in HAoSMC, and thrombin-mediated expression of IL-6 and CXCL8 was significantly inhibited by LY294002, AKT IV, RO318220, and GF109203X as well as by diphenyleneiodium at the messenger RNA and the protein levels. diphenyleneiodium 186-203 interleukin 6 Homo sapiens 84-88 20457835-2 2010 PGE(2) regulates IL-6 production in numerous different cells including macrophages and synovial fibroblasts. Prostaglandins E 0-3 interleukin 6 Homo sapiens 17-21 20457835-4 2010 Here, we investigate the mechanism of IL-6 induction in human T/C-28a2 chondrocytes treated with exogenously added PGE(2). Prostaglandins E 115-118 interleukin 6 Homo sapiens 38-42 20457835-5 2010 PGE(2) induces IL-6 mRNA and protein expression via a cAMP-dependent pathway, reaching maximal levels after 60 min of stimulation before declining to baseline levels at 6 h. Forskolin, an adenylyl cyclase activator, also stimulates IL-6 expression in human chondrocytes in a dose- and time-dependent fashion. Prostaglandins E 0-3 interleukin 6 Homo sapiens 15-19 22298069-5 2012 Accordingly, the combinational use of methotrexate and biologics targeting TNF and IL-6 has revolutionized the treatment of RA, producing significant improvements in clinical and structural outcomes, and has produced upcoming endpoint for the treatment as the clinical and structural remission. Methotrexate 38-50 interleukin 6 Homo sapiens 83-87 22010855-5 2012 On the other hand, the frequencies of the IL-6-634GG genotype and -634G allele were significantly decreased in the RSA group versus the control group (genotype: P = 0.0003; allele: P = 0.002), suggesting the IL-6-634C/G polymorphism might be a possible genetic protective factor for RSA. rabbit sperm membrane autoantigen 115-118 interleukin 6 Homo sapiens 42-46 22010855-5 2012 On the other hand, the frequencies of the IL-6-634GG genotype and -634G allele were significantly decreased in the RSA group versus the control group (genotype: P = 0.0003; allele: P = 0.002), suggesting the IL-6-634C/G polymorphism might be a possible genetic protective factor for RSA. rabbit sperm membrane autoantigen 115-118 interleukin 6 Homo sapiens 208-212 20457835-5 2010 PGE(2) induces IL-6 mRNA and protein expression via a cAMP-dependent pathway, reaching maximal levels after 60 min of stimulation before declining to baseline levels at 6 h. Forskolin, an adenylyl cyclase activator, also stimulates IL-6 expression in human chondrocytes in a dose- and time-dependent fashion. Prostaglandins E 0-3 interleukin 6 Homo sapiens 232-236 22010855-5 2012 On the other hand, the frequencies of the IL-6-634GG genotype and -634G allele were significantly decreased in the RSA group versus the control group (genotype: P = 0.0003; allele: P = 0.002), suggesting the IL-6-634C/G polymorphism might be a possible genetic protective factor for RSA. rabbit sperm membrane autoantigen 283-286 interleukin 6 Homo sapiens 42-46 20457835-5 2010 PGE(2) induces IL-6 mRNA and protein expression via a cAMP-dependent pathway, reaching maximal levels after 60 min of stimulation before declining to baseline levels at 6 h. Forskolin, an adenylyl cyclase activator, also stimulates IL-6 expression in human chondrocytes in a dose- and time-dependent fashion. Colforsin 174-183 interleukin 6 Homo sapiens 15-19 31106538-5 2019 CONCLUSION: alpha-MMC can significantly inhibit the synthesis and secretion of cytokines such as IL-6, IL-17A and TNF-alpha in hepatocytes, which may become a side effect of its anti-tumor application. alpha-mmc 12-21 interleukin 6 Homo sapiens 97-101 20457835-5 2010 PGE(2) induces IL-6 mRNA and protein expression via a cAMP-dependent pathway, reaching maximal levels after 60 min of stimulation before declining to baseline levels at 6 h. Forskolin, an adenylyl cyclase activator, also stimulates IL-6 expression in human chondrocytes in a dose- and time-dependent fashion. Colforsin 174-183 interleukin 6 Homo sapiens 232-236 20457835-6 2010 Inhibition of downstream effectors of cAMP activity such as protein kinase A (PKA) or phosphatidylinositol 3 kinase (PI3K) blocks PGE(2)- and forskolin-induced IL-6 upregulation. Prostaglandins E 130-133 interleukin 6 Homo sapiens 160-164 20457835-6 2010 Inhibition of downstream effectors of cAMP activity such as protein kinase A (PKA) or phosphatidylinositol 3 kinase (PI3K) blocks PGE(2)- and forskolin-induced IL-6 upregulation. Colforsin 142-151 interleukin 6 Homo sapiens 160-164 20457835-9 2010 p65 knockdown completely abrogates IL-6 mRNA synthesis in PGE(2)- and forskolin-primed chondrocytes. Colforsin 70-79 interleukin 6 Homo sapiens 35-39 20457835-10 2010 Cumulatively, our data show that PGE(2) and forskolin induce IL-6 expression in human chondrocytes via cAMP/PKA and PI3K-dependent pathways, which in turn regulate the activation and binding of p65 to the IL-6 promoter. Prostaglandins E 33-36 interleukin 6 Homo sapiens 61-65 22209282-9 2012 N-oleoyl-phytosphingosine increased the expression of MMP-1 and IL-6 mRNA, while decreasing the expression of COX-2 mRNA. ceramide 3 0-25 interleukin 6 Homo sapiens 64-68 22284780-11 2012 Specifically, apiegenin, baicalein, curcumin, EGCG, genistein, luteolin, oridonin, quercetin, and wogonin repress NF-kappaB (NF-kappaB, a proinflammatory transcription factor) and inhibit proinflammatory cytokines such as TNF-alpha and IL-6. Quercetin 83-92 interleukin 6 Homo sapiens 236-240 20457835-10 2010 Cumulatively, our data show that PGE(2) and forskolin induce IL-6 expression in human chondrocytes via cAMP/PKA and PI3K-dependent pathways, which in turn regulate the activation and binding of p65 to the IL-6 promoter. Prostaglandins E 33-36 interleukin 6 Homo sapiens 205-209 20457835-10 2010 Cumulatively, our data show that PGE(2) and forskolin induce IL-6 expression in human chondrocytes via cAMP/PKA and PI3K-dependent pathways, which in turn regulate the activation and binding of p65 to the IL-6 promoter. Colforsin 44-53 interleukin 6 Homo sapiens 61-65 20457835-10 2010 Cumulatively, our data show that PGE(2) and forskolin induce IL-6 expression in human chondrocytes via cAMP/PKA and PI3K-dependent pathways, which in turn regulate the activation and binding of p65 to the IL-6 promoter. Colforsin 44-53 interleukin 6 Homo sapiens 205-209 22287204-7 2012 RESULTS: Enhanced intensity PMMA-CHDF significantly increased mean arterial pressure by 23.8% in 1 hour (p=0.037), decreased the blood lactate level by 28.6% in 12 hours (p=0.006), and reduced blood IL-6 level in 24 hours (p=0.005). pmma-chdf 28-37 interleukin 6 Homo sapiens 199-203 31435158-2 2019 20 known inhibitors towards IL-6 were screened and Methotrexate (MTX) having PubChem ID: 126941 showed high binding capacity with the receptor IL-6. Methotrexate 51-63 interleukin 6 Homo sapiens 28-32 22420547-7 2012 A decrease in Il-6 level after application of Cisplatin and Methotrexate and a 5-10 fold increase in the level of Il-6 after application of Etoposide, Carboplatin, Cytarabine, and Gemcitabine were registered in the medium with ganglioneuroblastoma. Methotrexate 60-72 interleukin 6 Homo sapiens 14-18 22605930-10 2012 Interestingly, Travatan and Systane Ultra activated NF-kappaB and elevated the secretion of inflammation markers IL-6 by 3 to eightfold and IL-8 by 1.5 to 3.5 fold, respectively, as analyzed with ELISA. Travoprost 15-23 interleukin 6 Homo sapiens 113-117 20201942-0 2010 Emergent T-helper 2 profile with high interleukin-6 levels correlates with the appearance of bortezomib-induced neuropathic pain. Bortezomib 93-103 interleukin 6 Homo sapiens 38-51 31435158-2 2019 20 known inhibitors towards IL-6 were screened and Methotrexate (MTX) having PubChem ID: 126941 showed high binding capacity with the receptor IL-6. Methotrexate 51-63 interleukin 6 Homo sapiens 143-147 30597899-6 2018 Intracellular TNF and interleukin 6 (IL-6) protein also increased in HCtAEC supplemented with SAA and this expression was inhibited by BAY11-7082. 3-(4-methylphenylsulfonyl)-2-propenenitrile 135-145 interleukin 6 Homo sapiens 22-35 20603592-7 2010 IL-6 showed a better agreement with treatment response (MTX group, K=0.58; non-MTX group, K=0.21) than ESR or CRP, whereas TNFalpha did not show an agreement with treatment response. Methotrexate 56-59 interleukin 6 Homo sapiens 0-4 22302924-0 2012 Intraperitoneal IL-6 signaling in incident patients treated with icodextrin and glucose bicarbonate/lactate-based peritoneal dialysis solutions. Icodextrin 65-75 interleukin 6 Homo sapiens 16-20 30597899-6 2018 Intracellular TNF and interleukin 6 (IL-6) protein also increased in HCtAEC supplemented with SAA and this expression was inhibited by BAY11-7082. 3-(4-methylphenylsulfonyl)-2-propenenitrile 135-145 interleukin 6 Homo sapiens 37-41 20603592-7 2010 IL-6 showed a better agreement with treatment response (MTX group, K=0.58; non-MTX group, K=0.21) than ESR or CRP, whereas TNFalpha did not show an agreement with treatment response. Methotrexate 79-82 interleukin 6 Homo sapiens 0-4 30598636-1 2018 Objective: To investigate the role and possible molecular mechanism of Kruppel-like factor 7 (KLF7) in the TLR4/NF-kappaB/IL-6 inflammatory signaling pathway activated by free fatty acids (FFA). Fatty Acids, Nonesterified 171-187 interleukin 6 Homo sapiens 122-126 20526368-4 2010 Increased levels of free fatty acids (FFA), as observed in obese patients, can induce IL-6 production in various cell types. Fatty Acids, Nonesterified 20-36 interleukin 6 Homo sapiens 86-90 20526368-4 2010 Increased levels of free fatty acids (FFA), as observed in obese patients, can induce IL-6 production in various cell types. Fatty Acids, Nonesterified 38-41 interleukin 6 Homo sapiens 86-90 21988173-3 2011 QSAR study revealed that the presence of electron-withdrawing groups in B-ring and electron-donating groups in A-ring of chalcones was important for inhibition of LPS-induced IL-6 expression. Chalcones 121-130 interleukin 6 Homo sapiens 175-179 30259402-6 2018 Anti-cancer effect of honokiol was demonstrated with the decrease in the release of cytokine IL-6 and further suppression of Ki-67 proliferative protein. honokiol 22-30 interleukin 6 Homo sapiens 93-97 21801267-6 2011 Among allelic variant of IRS-2, concentrations of IL-6 were greater in IRS-2 homozygous Asp population. Aspartic Acid 88-91 interleukin 6 Homo sapiens 50-54 21801267-7 2011 Treatment with metformin significantly reduced IL-6, especially in PCOS patients with IRS-2 homozygous Asp variant. Aspartic Acid 103-106 interleukin 6 Homo sapiens 47-51 20347935-3 2010 In vitro, anti-miRNA-125b added exogenously to IL-6-stressed NHA cultures attenuated both glial cell proliferation and increased the expression of the cyclin-dependent kinase inhibitor 2A (CDKN2A), a miRNA-125b target and negative regulator of cell growth. mirna-125b 15-25 interleukin 6 Homo sapiens 47-51 19929981-0 2010 Chitosan oligosaccharides inhibit the expression of interleukin-6 in lipopolysaccharide-induced human umbilical vein endothelial cells through p38 and ERK1/2 protein kinases. chitosan oligosaccharides 0-25 interleukin 6 Homo sapiens 52-65 30025340-7 2018 In this study, switching from HSF (1.12% S) to LSF (0.38% S) reduced emitted PM by 12%, OC by 20%, sulfate by 71%, and particulate PAHs by 94%, but caused an increase in single-ring aromatics. Polycyclic Aromatic Hydrocarbons 131-135 interleukin 6 Homo sapiens 30-33 20423350-5 2010 KEY RESULTS: Pre-incubation with beta(2)-adrenoceptor agonists (salbutamol, salmeterol, formoterol) augmented the release and mRNA expression of IL-6 and IL-8 induced by IL-1beta and IL-1beta plus histamine, whereas NF-kappaB-dependent transcription was significantly repressed, and AP-1-dependent transcription was unaffected. Salmeterol Xinafoate 76-86 interleukin 6 Homo sapiens 145-149 20423350-8 2010 Addition of dexamethasone with salmeterol repressed IL-6 and IL-8 release to levels that were similar to the repression achieved in the absence of salmeterol. Salmeterol Xinafoate 31-41 interleukin 6 Homo sapiens 52-56 21704648-4 2011 Furthermore, the release and expression levels of inflammatory cytokines; including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) were also attenuated by COS. oligochitosan 203-206 interleukin 6 Homo sapiens 125-138 29933233-5 2018 The macrophages cultured on Cu-containing MAO-fabricated surfaces were polarized to M1 phenotype, evidenced by the high expression levels of inducible nitric oxide synthase (iNOS), low expression levels of arginase1 (Arg1), enhanced pro-inflammatory cytokine interleukin-6 (IL-6) release and inhibited IL-4 and IL-10 (anti-inflammatory cytokines) release. 5'-DEOXY-5'-[N-METHYL-N-(2-AMINOOXYETHYL) AMINO]ADENOSINE 42-45 interleukin 6 Homo sapiens 259-272 21734258-9 2011 However, RLN activation of RXFP1 induced a dose-dependent cAMP response, which when mimicked by forskolin also caused significantly increased (P < 0.05) secretion of IL6. Colforsin 96-105 interleukin 6 Homo sapiens 169-172 20423350-9 2010 IL-6 release was enhanced when salmeterol was added before, concurrently or after IL-1beta plus histamine stimulation, whereas IL-8 release was only enhanced by salmeterol addition prior to stimulation. Salmeterol Xinafoate 31-41 interleukin 6 Homo sapiens 0-4 20395894-11 2010 The ADMA/SDMA ratio was inversely related to IL-6 levels. symmetric dimethylarginine 9-13 interleukin 6 Homo sapiens 45-49 29933233-5 2018 The macrophages cultured on Cu-containing MAO-fabricated surfaces were polarized to M1 phenotype, evidenced by the high expression levels of inducible nitric oxide synthase (iNOS), low expression levels of arginase1 (Arg1), enhanced pro-inflammatory cytokine interleukin-6 (IL-6) release and inhibited IL-4 and IL-10 (anti-inflammatory cytokines) release. 5'-DEOXY-5'-[N-METHYL-N-(2-AMINOOXYETHYL) AMINO]ADENOSINE 42-45 interleukin 6 Homo sapiens 274-278 19823118-0 2010 Lipoteichoic acid-induced TNF-alpha and IL-6 gene expressions and oxidative stress production in macrophages are suppressed by ketamine through downregulating Toll-like receptor 2-mediated activation oF ERK1/2 and NFkappaB. lipoteichoic acid 0-17 interleukin 6 Homo sapiens 40-44 20233902-0 2010 Sulforaphane inhibits constitutive and interleukin-6-induced activation of signal transducer and activator of transcription 3 in prostate cancer cells. sulforaphane 0-12 interleukin 6 Homo sapiens 39-52 21817129-6 2011 RESULTS: Monocytes incubated with SDMA showed increased IL-6 and TNF-alpha expression and a rise in active NF-kappaB. symmetric dimethylarginine 34-38 interleukin 6 Homo sapiens 56-60 21817129-10 2011 Correlations between SDMA and IL-6, TNF-alpha, and albumin were more significant than for ADMA, while multiple regression analysis only retained TNF-alpha at a high significance for SDMA (P < 0.0001). symmetric dimethylarginine 21-25 interleukin 6 Homo sapiens 30-34 21817129-11 2011 In receiver operating characteristic analysis for inflammation, defined as an IL-6 level above 2.97 pg/ml (median), the discriminative power of SDMA (area under the curve [AUC]: 0.69 +- 0.05) directly followed that of C-reactive protein (AUC: 0.82 +- 0.04) and albumin (AUC: 0.72 +- 0.05; for all, P < 0.0001) and preceded that of ADMA (P = 0.002). symmetric dimethylarginine 144-148 interleukin 6 Homo sapiens 78-82 21817129-12 2011 CONCLUSIONS: The present study shows that SDMA is involved in the inflammatory process of CKD, activating NF-kappaB and resulting in enhanced expression of IL-6 and TNF-alpha, which is corroborated by the clinical data pointing to an in vivo association of SDMA with inflammatory markers in CKD at different stages. symmetric dimethylarginine 42-46 interleukin 6 Homo sapiens 156-160 20170185-1 2010 In light of the unique ability of thiazolidinediones to mediate peroxisome proliferator-activated receptor (PPAR)gamma-independent activation of adenosine monophosphate-activated protein kinase (AMPK) and suppression of interleukin (IL)-6 production, we conducted a screening of an in-house, thiazolidinedione-based focused compound library to identify novel agents with these dual pharmacological activities. Thiazolidinediones 34-52 interleukin 6 Homo sapiens 220-238 21817129-12 2011 CONCLUSIONS: The present study shows that SDMA is involved in the inflammatory process of CKD, activating NF-kappaB and resulting in enhanced expression of IL-6 and TNF-alpha, which is corroborated by the clinical data pointing to an in vivo association of SDMA with inflammatory markers in CKD at different stages. symmetric dimethylarginine 257-261 interleukin 6 Homo sapiens 156-160 30516500-0 2018 CLINICAL-PATHOGENETICAL ROLE OF DYNAMICS OF CONCENTRATION OF INTERLEUKIN-6 DEPENDING ON POLYMORPHISM OF ITS GENE IN CONDUCTING ANTIVIRAL THERAPY IN PATIENTS WITH CHRONIC HEPATITIS C. The study included 83 patients with CHC who received antiviral therapy according to the EASL 2016 recommendations on a 12-week peg-IFN+SOF+RBV schedule. Ribavirin 322-325 interleukin 6 Homo sapiens 61-74 30516500-3 2018 In patients with CHC, the genotype CC of the polymorphism of the IL-6 gene was associated with fluctuations in the concentration of IL-6 in the blood within the reference range, which was prognostically favorable for the formation of SVR 24 for AVT according to the peg-IFNalpha + SOF + RBV. Ribavirin 287-290 interleukin 6 Homo sapiens 65-69 20472992-4 2010 Patients with blood IL-6 level > or =400 pg/ml were considered indicated for initiation of PMMA-CHDF based on our previous data. pmma-chdf 94-103 interleukin 6 Homo sapiens 20-24 20472992-7 2010 Mean blood IL-6 level, which was 998 pg/ml on admission to the ICU, was significantly lower (335 pg/ml) after 3 days treatment of PMMA-CHDF (p < 0.01). pmma-chdf 130-139 interleukin 6 Homo sapiens 11-15 30516500-3 2018 In patients with CHC, the genotype CC of the polymorphism of the IL-6 gene was associated with fluctuations in the concentration of IL-6 in the blood within the reference range, which was prognostically favorable for the formation of SVR 24 for AVT according to the peg-IFNalpha + SOF + RBV. Ribavirin 287-290 interleukin 6 Homo sapiens 132-136 20472992-9 2010 At the time of weaning from PMMA-CHDF, blood IL-6 level had decreased to 99 pg/ml. pmma-chdf 28-37 interleukin 6 Homo sapiens 45-49 21615409-2 2011 We comprehensively assessed the involvement of MAPKs, activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) in IL-1beta-induced production of interleukin-6 (IL-6), interleukin-8 (IL-8), prostaglandin E(2) (PGE(2) ) and MMP-1 in human periodontal ligament cells. Prostaglandins E 197-212 interleukin 6 Homo sapiens 168-172 21615409-2 2011 We comprehensively assessed the involvement of MAPKs, activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) in IL-1beta-induced production of interleukin-6 (IL-6), interleukin-8 (IL-8), prostaglandin E(2) (PGE(2) ) and MMP-1 in human periodontal ligament cells. Prostaglandins E 217-220 interleukin 6 Homo sapiens 168-172 20472994-3 2010 In our previous study, it was found that PMMA-CHDF could efficiently remove various pro-inflammatory cytokines such as TNFalpha, IL-6 and IL-8 from the bloodstream, resulting in early recovery from septic shock. pmma-chdf 41-50 interleukin 6 Homo sapiens 129-133 30516500-5 2018 The ineffectiveness of AVT according to the scheme peg-IFNalpha+SOF+RBV was associated with the presence of CG/GG genotypes and the highest concentration of IL-6 in the blood. Ribavirin 68-71 interleukin 6 Homo sapiens 157-161 20472995-7 2010 Significant correlations between changes in blood levels of cytokines (IL-6 and IL-8) and changes in RI were demonstrated in the PMMA-CHDF group. Polymethyl Methacrylate 129-133 interleukin 6 Homo sapiens 71-75 20472995-7 2010 Significant correlations between changes in blood levels of cytokines (IL-6 and IL-8) and changes in RI were demonstrated in the PMMA-CHDF group. chdf 134-138 interleukin 6 Homo sapiens 71-75 29030990-6 2018 Moreover, nanohydrogel of quercetin was able to reduce significantly IL-8, IL-6, and VEGF production in pro-inflammatory conditions with interesting implications on the mechanism of glioblastoma cells drug resistance. Quercetin 26-35 interleukin 6 Homo sapiens 75-79 20731121-0 2010 [Influence of polyoxidonium on IL-1 beta, TNF-alpha and IL-6 production by mononuclears and monocytes under the dexamethasone effect]. azoximer bromide 14-27 interleukin 6 Homo sapiens 56-60 20731121-1 2010 It was established that in a mononuclear fraction polyoxidonium inhibited the TNF-alpha production and stimulated the IL-1 beta and IL-6 production. azoximer bromide 50-63 interleukin 6 Homo sapiens 132-136 20731121-2 2010 In LPS-induced mononuclear cultures polyoxidonium inhibited the IL-6 production and had no statistically significant effect on the synthesis of TNF-alpha and IL-1 beta. azoximer bromide 36-49 interleukin 6 Homo sapiens 64-68 21744278-6 2011 Consistent with these data, SP600125 prevented t10,c12 CLA-mediated secretion of IL-8, IL-6, and MCP-1. pyrazolanthrone 28-36 interleukin 6 Homo sapiens 87-91 29155150-8 2018 We inhibited systemic inflammation in old subjects by means of pretreatment with an oral small-molecule p38 mitogen-activated protein kinase inhibitor (Losmapimod; GlaxoSmithKline, Brentford, United Kingdom), which reduced both serum C-reactive protein levels and peripheral blood monocyte secretion of IL-6 and TNF-alpha. 6-(5-((cyclopropylamino)carbonyl)-3-fluoro-2-methylphenyl)-N-(2,2-dimethylprpyl)-3-pyridinecarboxamide 152-162 interleukin 6 Homo sapiens 303-307 21914162-6 2011 Compared with consuming no coffee, consumption of caffeinated coffee increased adiponectin (difference in change from baseline 1.4 mug/mL; 95% CI: 0.2, 2.7) and interleukin-6 (difference: 60%; 95% CI: 8, 138) concentrations and consumption of decaffeinated coffee decreased fetuin-A concentrations (difference: -20%; 95% CI: -35, -1). caffeinated 50-61 interleukin 6 Homo sapiens 161-174 21664353-8 2011 Several genes, including interferon regulatory factor 1 (IRF1) interleukin-6 (IL-6) and prostaglandin-endoperoxide synthase 2 (COX-2) were induced in CAFs during co-culture. cafs 150-154 interleukin 6 Homo sapiens 63-76 21664353-8 2011 Several genes, including interferon regulatory factor 1 (IRF1) interleukin-6 (IL-6) and prostaglandin-endoperoxide synthase 2 (COX-2) were induced in CAFs during co-culture. cafs 150-154 interleukin 6 Homo sapiens 78-82 19772942-6 2009 In vitro, CoVaccineHT upregulated the expression of co-stimulatory molecules both on mouse and human dendritic cells and induced the secretion of pro-inflammatory cytokines TNF-alpha, IL-6, IL-1beta and IL-12p70 in mouse- and IL-6 in human dendritic cells. covaccineht 10-21 interleukin 6 Homo sapiens 184-188 29961188-8 2018 Moreover, the two different methanol extracts and compounds 1-4 decreased IL-6 production in a strong and concentration-dependent manner by the ELISA method. Methanol 28-36 interleukin 6 Homo sapiens 74-78 20214221-7 2009 Lovastatin administration resulted in the significant decrease of the pro-inflammatory cytokines IL-6 and TNF-alfa, while that of fluvastatin brought about the significant decrease of the serum levels of IL-6, IL-8 and TNF-alfa. Fluvastatin 130-141 interleukin 6 Homo sapiens 204-208 20214221-10 2009 CONCLUSIONS: Lovastatin and fluvastatin, significantly decrease the level of viremia, of IL-6 and TNF-alpha in the patients with chronic hepatitis C. Fluvastatin 28-39 interleukin 6 Homo sapiens 89-93 20592661-4 2011 The angiotensin-converting enzyme inhibitors like captopril and enalapril as well as the angiotensin II receptor antagonist losartan indicated in HF exerted reducing effects on the inflammatory cytokines such as tumor necrosis factor-alpha and interleukin-6 at experimental and clinical levels. Enalapril 64-73 interleukin 6 Homo sapiens 244-257 19665805-7 2009 In comparison with fertile women, those with RSA showed significantly increased levels of soluble IL-6 receptor and IL-6, and decreased levels of soluble gp130, the trans-signaling inhibitor. rabbit sperm membrane autoantigen 45-48 interleukin 6 Homo sapiens 98-102 21784820-7 2011 RESULTS: Serum IL-6 increased in patients receiving calcium acetate, whereas hs-CRP and IL-6 significantly decreased in subjects treated with sevelamer, with IL-10 experiencing a trend to increase (P = 0.052). calcium acetate 52-67 interleukin 6 Homo sapiens 15-19 29726034-0 2018 Flavonoids from Boldoa purpurascens inhibit proinflammatory cytokines (TNF-alpha and IL-6) and the expression of COX-2. Flavonoids 0-10 interleukin 6 Homo sapiens 85-89 21949922-5 2011 Recently, an anti-IL-6 receptor monoclonal antibody, tocilizumab, has been licensed for the treatment as monotherapy or in combination with methotrexate of moderate to severe RA, when disease modifying anti-rheumatic drugs or anti-tumour necrosis factors (TNF) have failed. Methotrexate 140-152 interleukin 6 Homo sapiens 18-22 19665805-7 2009 In comparison with fertile women, those with RSA showed significantly increased levels of soluble IL-6 receptor and IL-6, and decreased levels of soluble gp130, the trans-signaling inhibitor. rabbit sperm membrane autoantigen 45-48 interleukin 6 Homo sapiens 116-120 29768726-6 2018 Further study indicated that UVB-induced production of MMP-1 and IL-6 could be inhibited by PD 98059 (an inhibitor of ERK) and SP600125 (an inhibitor of JNK). pyrazolanthrone 127-135 interleukin 6 Homo sapiens 65-69 19395583-12 2009 Plasma interleukin (IL)-6 levels significantly increased 2 h after exercise only in the DCA condition (p < 0.01). Dichloroacetic Acid 88-91 interleukin 6 Homo sapiens 7-25 30154433-4 2018 In this study, we investigated the effect of SASP-related p16/IL6 axis on sorafenib resistance in HCC. Sorafenib 74-83 interleukin 6 Homo sapiens 62-65 19648274-5 2009 Indeed, we found that IL-6, but not other Stat3-activating cytokines, was necessary and sufficient to reverse human T cell suppression by Treg in an in vitro model using activated DCs as a source of IL-6. treg 138-142 interleukin 6 Homo sapiens 22-26 21752043-0 2011 Porphyromonas gingivalis lipopolysaccharide lipid A heterogeneity differentially modulates the expression of IL-6 and IL-8 in human gingival fibroblasts. Lipid A 44-51 interleukin 6 Homo sapiens 109-113 30154433-5 2018 Initially, we noticed that HCC cells with a high level of p16/IL6 axis exhibited a low sensitivity to sorafenib. Sorafenib 102-111 interleukin 6 Homo sapiens 62-65 30154433-7 2018 Overexpression of ID1 or IL6 blocking in sorafenib-resistant HCC cells could increase the cytotoxicity of sorafenib. Sorafenib 41-50 interleukin 6 Homo sapiens 25-28 30154433-7 2018 Overexpression of ID1 or IL6 blocking in sorafenib-resistant HCC cells could increase the cytotoxicity of sorafenib. Sorafenib 106-115 interleukin 6 Homo sapiens 25-28 21823012-6 2011 The levels of TNF-alpha, IL-2, IL-6 and COX-2 were found to be substantially decreased in PBMCs in omega-3PUFA group as compared with control group at 5th and 7th day (P<0.05 for all). omega-3pufa 99-110 interleukin 6 Homo sapiens 31-35 19564644-7 2009 Medroxyprogesterone acetate significantly suppressed LPS-induced production of interleukin 1b (IL-1b), IL-6, and IL-8 in vitro (P < .05). Medroxyprogesterone Acetate 0-27 interleukin 6 Homo sapiens 103-107 30154433-8 2018 Moreover, SASP-related p16/IL6 axis contributed to the formation of acquired resistance in cells received long-term exposure to sorafenib. Sorafenib 128-137 interleukin 6 Homo sapiens 27-30 21414799-3 2011 Using sodium nitroprusside (SNP) and S-nitrosoglutathione (GSNO) as NO-donating compounds, we observed that both mRNA and protein levels of IL-6 increased at lower (<=10muM) and decreased at higher (>100muM) concentrations of NO donors. Nitroprusside 6-26 interleukin 6 Homo sapiens 140-144 30154433-9 2018 In acquired sorafenib-resistant cells, ID1 low expression, p16/IL6 axis up-regulation, and AKT phosphorylation activation were observed. Sorafenib 12-21 interleukin 6 Homo sapiens 63-66 30154433-11 2018 The reversal of sorafenib resistance could be achieved through ID1 overexpression, IL6 blocking, and AKT pathway inhibition. Sorafenib 16-25 interleukin 6 Homo sapiens 83-86 19653909-5 2009 We found the short-term (<24 h) activation of IL-6 involved the coordinate up-regulation of toll-like receptor-4 (TLR4) with complementary changes to NEU3 and ST3GAL5 that reduced ganglioside GM3 in a manner that augmented the activation of TLR4 and IL-6. Gangliosides 183-194 interleukin 6 Homo sapiens 49-53 30154433-12 2018 Our study reveals that SASP-related p16/IL6 axis activation is responsible for sorafenib resistance, which will be a novel strategy to prevent the drug resistance. Sorafenib 79-88 interleukin 6 Homo sapiens 40-43 21331764-6 2011 In the cells treated with sorafenib, phosphorylation of mitogen-activated protein kinase kinase (MEK) and mitogen-activated protein kinase (MAPK) and also interleukin-6-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3) were inhibited in a dose-dependent manner. Sorafenib 26-35 interleukin 6 Homo sapiens 155-168 30069732-6 2018 Patients with steroid- and methotrexate-refractory AOSD can now benefit from efficient and well-tolerated biologic agents such as IL-1, IL-6, and tumor necrosis factor-alpha antagonists. Methotrexate 27-39 interleukin 6 Homo sapiens 136-140 21484151-8 2011 Our results showed that cerulein induced IL-6 expression in a time-dependent manner. Ceruletide 24-32 interleukin 6 Homo sapiens 41-45 19438975-7 2009 In addition, the increase of IL-6 secretion induced by P. gingivalis infection was significantly impaired by the meiosis specific kinase 1 inhibitor, PD98059, or the nuclear factor kappaB inhibitor, Bay11-7082. 3-(4-methylphenylsulfonyl)-2-propenenitrile 199-209 interleukin 6 Homo sapiens 29-33 21484151-10 2011 Lycopene inhibited the cerulein-induced increase in intracellular ROS, NF-kappaB activation, and IL-6 expression in pancreatic acinar cells in a dose-dependent manner. Ceruletide 23-31 interleukin 6 Homo sapiens 97-101 30055667-6 2018 RESULTS: In the absence of bacteria, TBBPA tended to increase P4 and T as well as IL-6 and 8-IsoP. tetrabromobisphenol A 37-42 interleukin 6 Homo sapiens 82-86 20158569-9 2011 Simvastatin, atorvastatin, fluvastatin or pravastatin reduced the IL-6 production by 53%, 50%, 64% and 60%, respectively. Fluvastatin 27-38 interleukin 6 Homo sapiens 66-70 19885014-5 2009 Results showed that EPA, DHA, or troglitazone significantly reduced COX-2 expression, NF-kappaB luciferase activity, and PGE(2) and IL-6 production in a dose-dependent fashion. Troglitazone 33-45 interleukin 6 Homo sapiens 132-136 19542367-8 2009 In conclusion, PGE(2) differentially affects TNF-alpha-induced mRNA expression of proinflammatory IL-6 and prodestructive MMP-1 regarding the usage of EP receptors and the dependency on cAMP. Prostaglandins E 15-18 interleukin 6 Homo sapiens 98-102 19542367-9 2009 Although specific blockade of EP2 receptors is considered a promising therapeutic strategy in RA, opposite regulation of proinflammatory IL-6 and prodestructive MMP-1 by PGE(2) via EP2 may require more complex approaches to successfully inhibit the cyclooxygenase-1/2 cAMP axis. Prostaglandins E 170-173 interleukin 6 Homo sapiens 137-141 21307288-4 2011 Inhibition of Stat3 signaling in MLCs containing IL-6 restores Treg-mediated suppression, demonstrating that IL-6-mediated loss of Treg suppression requires phosphorylation of Stat3. treg 63-67 interleukin 6 Homo sapiens 49-53 30055667-7 2018 For bacteria-treated cultures, TBBPA generally inhibited P4, IL-1beta, and HO-1 production but enhanced TNF-alpha and IL-6 production. tetrabromobisphenol A 31-36 interleukin 6 Homo sapiens 118-122 21307288-4 2011 Inhibition of Stat3 signaling in MLCs containing IL-6 restores Treg-mediated suppression, demonstrating that IL-6-mediated loss of Treg suppression requires phosphorylation of Stat3. treg 63-67 interleukin 6 Homo sapiens 109-113 30055667-8 2018 CONCLUSIONS: TBBPA alters placental steroidogenesis to favor T production and increases oxidative stress and placental inflammation as suggested by its promotion of 8-IsoP and IL-6 production. tetrabromobisphenol A 13-18 interleukin 6 Homo sapiens 176-180 19285039-7 2009 Treatment with forskolin, an agent that mimics axonal signaling, suppressed the expression of IL-6-inducible genes. Colforsin 15-24 interleukin 6 Homo sapiens 94-98 30055667-9 2018 TBBPA may also function as a risk modifier where it enhances bacteria-stimulated production TNF-alpha and IL-6 but reduces HO-1 production, however, this was balanced by reductions in IL-1beta. tetrabromobisphenol A 0-5 interleukin 6 Homo sapiens 106-110 30054566-6 2018 IL-1beta and IFN- gamma significantly increased IL-6 production in HNECs derived from CRS patients and controls, however, a dose-dependent effect was observed in CRS-derived HNECs only. 3-cresol 86-89 interleukin 6 Homo sapiens 48-52 19236332-6 2009 Therefore, cell-wall components of bacteria (lipopolysaccharide, muramyl dipeptide, diamino pimelic acid) stimulate IL-6 production in normal and tumoral pituitary. Diaminopimelic Acid 84-104 interleukin 6 Homo sapiens 116-120 21342228-3 2011 This study was conducted to review sorafenib-associated HSF in Japanese patients, to facilitate improvement of the management of HFS in clinical practice. Sorafenib 35-44 interleukin 6 Homo sapiens 56-59 20713976-8 2011 Exposure of HPMC to 3.4-DGE resulted in suppression of HSP, and increased release of LDH, IL-6 and IL-8. 3,4-dideoxyglucosone-3-ene 20-27 interleukin 6 Homo sapiens 90-94 29792808-8 2018 Following PAR treatment, the production of IL-2, IFN-gamma, IL-6, and TNF-alpha could be significantly reduced by an infusion of clinically relevant concentrations of the FDA-approved antibiotic, trimethoprim, signaling pharmacologic PAR deactivation. Trimethoprim 196-208 interleukin 6 Homo sapiens 60-64 20663020-8 2011 RESULTS: Pretreatment of PBMCs with alendronate promoted lipid A-induced production of IL-1beta and IL-6, but decreased lipid A-induced IL-8 and MCP-1 production. Lipid A 57-64 interleukin 6 Homo sapiens 100-104 20663020-9 2011 In human gingival fibroblasts, alendronate pretreatment increased lipid A-induced production of IL-6 and IL-8, and increased NF-kappaB activation in gingival fibroblasts but not PBMCs stimulated with lipid A. Lipid A 66-73 interleukin 6 Homo sapiens 96-100 20632303-6 2011 Further studies revealed that only oleanolic acid and ursolic acid, but not betulinic acid, could inhibit the lipopolysaccharide induced interleukin-6 release from Mono Mac 6 cells when tested separately. Oleanolic Acid 35-49 interleukin 6 Homo sapiens 137-150 22018243-5 2011 The effect of sBAFF itself on the production of IL-6 was also studied. sbaff 14-19 interleukin 6 Homo sapiens 48-52 19886316-3 2009 In this patient, peritoneal permeability to high molecular weight solutes and effluent interleukin-6 (IL-6) levels increased after initiation on-to icodextrin solution. Icodextrin 148-158 interleukin 6 Homo sapiens 87-100 29678772-7 2018 The improvement in negative symptoms with minocycline was significantly correlated with the reduction of IL-1beta and IL-6 serum levels (P < 0.05). Minocycline 42-53 interleukin 6 Homo sapiens 118-122 19886316-3 2009 In this patient, peritoneal permeability to high molecular weight solutes and effluent interleukin-6 (IL-6) levels increased after initiation on-to icodextrin solution. Icodextrin 148-158 interleukin 6 Homo sapiens 102-106 22018243-10 2011 In addition, stimulation of pSS monocytes with sBAFF induced a significant increase in IL-6 production. sbaff 47-52 interleukin 6 Homo sapiens 87-91 29973533-5 2018 Kahweol decreased the LPS-induced production of interleukin 1 alpha, interleukin 1 beta, interleukin 6, and tumor necrosis factor alpha. kahweol 0-7 interleukin 6 Homo sapiens 89-102 22085408-8 2011 Pulmonary levels of suPAR highly correlated with pulmonary levels of interleukin 6, a marker of inflammation, and thrombin-antithrombin complexes, markers of coagulation, but not plasminogen activator activity, a marker of fibrinolysis. supar 20-25 interleukin 6 Homo sapiens 69-82 20663948-9 2010 Bortezomib induced apoptosis and a decrease of both interleukin-6/interleukin-10 secretion and STAT3 phosphorylation. Bortezomib 0-10 interleukin 6 Homo sapiens 52-65 20003352-12 2009 A significant inverse association was found between IL-6, IL-8 and PaO2 in critical patients. pao2 67-71 interleukin 6 Homo sapiens 52-56 19606255-6 2009 A significant increase of IL-6, IL-12, IFN-gamma and TNF-alpha was observed in the HI group after treatment with FR-91. hi 83-85 interleukin 6 Homo sapiens 26-30 30090037-9 2018 Results: Mgamma-Mphis produced a large amount of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 in response to beta-(1,3)-glucan. beta-1,3-glucan 122-139 interleukin 6 Homo sapiens 93-106 19648778-0 2009 Interleukin-10 and interleukin-6 in aqueous humor during treatment of vitreoretinal lymphoma with intravitreally injected methotrexate. Methotrexate 122-134 interleukin 6 Homo sapiens 19-32 19648778-1 2009 OBJECTIVE: To evaluate the effectiveness of measuring anterior chamber interleukin (IL)-10 and IL-6 concentrations during treatment of vitreoretinal lymphoma with intravitreally injected methotrexate. Methotrexate 187-199 interleukin 6 Homo sapiens 95-99 20732995-6 2010 MIMLh5 efficiently reduced the induction of interleukin-6 (IL-6), IL-8, and tumor necrosis factor alpha (TNF-alpha), in a dose-dependent manner. mimlh5 0-6 interleukin 6 Homo sapiens 44-57 20732995-6 2010 MIMLh5 efficiently reduced the induction of interleukin-6 (IL-6), IL-8, and tumor necrosis factor alpha (TNF-alpha), in a dose-dependent manner. mimlh5 0-6 interleukin 6 Homo sapiens 59-63 18380546-12 2009 Higher levels of serum protein S-100B and IL-6 correlated with ultrastructural changes of endothelial cells, and with inflammatory response following TBI, respectively. Thioacetazone 150-153 interleukin 6 Homo sapiens 42-46 29457280-8 2018 Besides, levels of PE750, PI885, PC792, PC826, PC830, PC854, PC802, and PG747 had an obvious negative correlation with levels of TNF-alpha, IL-10, IL-6, BUN, SCr, and PaCO2 , and a significant positive correlation with levels of HCO3- , PaO2 , and SaO2 . pao2 237-241 interleukin 6 Homo sapiens 147-151 19278477-1 2008 BACKGROUND: To investigate sequential changes of aqueous vascular endothelial growth factor (VEGF) and interleukin (IL)-6 in macular oedema secondary to branch retinal vein occlusion after single intravitreal injection of triamcinolone acetonide (IVTA). Triamcinolone Acetonide 222-245 interleukin 6 Homo sapiens 103-121 20725963-1 2010 The formation of hypertrophic scars (HSF) is a frequent medical outcome of wound repair and often requires further therapy with treatments such as silicone gel sheets (SGS) or apoptosis-inducing agents, including bleomycin. Bleomycin 213-222 interleukin 6 Homo sapiens 37-40 29579332-10 2018 PC786 showed inhibitory activities against RSV-induced increases of CCL5, IL-6, double-strand DNA and mucin. Respiratory Syncytial Virus Vaccines 43-46 interleukin 6 Homo sapiens 74-78 20959795-5 2010 In addition, we observed that the plasma levels of interleukin (IL)-6 were higher in the DSS-treated group than in the control group, but these increased levels were reduced by the administration of vanillic acid. Dextran Sulfate 89-92 interleukin 6 Homo sapiens 51-69 18776065-9 2008 LPS- and TNFalpha-stimulated production of TNFalpha and IL-6 in rodents also was inhibited by pamapimod. pamapimod 94-103 interleukin 6 Homo sapiens 56-60 18954528-0 2008 Expression of interleukin-6 is downregulated by 17-(allylamino)-17-demethoxygeldanamycin in human prostatic carcinoma cells. tanespimycin 48-88 interleukin 6 Homo sapiens 14-27 29899697-3 2018 Icariin also suppressed IL-6-induced STAT3 activation through the inhibition of upstream kinases (Janus activated kinase-1 and -2, and c-Src). icariin 0-7 interleukin 6 Homo sapiens 24-28 18954528-2 2008 We evaluated the mechanism and effect of 17-(allylamino)-17-demethoxygeldanamycin (17AAG), a novel inhibitor of heat shock protein 90 (Hsp90), on the IL-6 gene expression in human prostatic carcinoma (PC-3) cells. tanespimycin 41-81 interleukin 6 Homo sapiens 150-154 18954528-2 2008 We evaluated the mechanism and effect of 17-(allylamino)-17-demethoxygeldanamycin (17AAG), a novel inhibitor of heat shock protein 90 (Hsp90), on the IL-6 gene expression in human prostatic carcinoma (PC-3) cells. tanespimycin 83-88 interleukin 6 Homo sapiens 150-154 18954528-4 2008 The deregulation of 17AAG and phorbol 12-myristate 13-acetate (PMA) on the IL-6 gene was determined by ELISA and transient gene expression assays using an IL-6 reporter vector. tanespimycin 20-25 interleukin 6 Homo sapiens 75-79 18954528-4 2008 The deregulation of 17AAG and phorbol 12-myristate 13-acetate (PMA) on the IL-6 gene was determined by ELISA and transient gene expression assays using an IL-6 reporter vector. tanespimycin 20-25 interleukin 6 Homo sapiens 155-159 20309718-8 2010 BAY 11-7082 treatment abolished C3G-induced reduction of TNFalpha and IL-6. 3-(4-methylphenylsulfonyl)-2-propenenitrile 0-11 interleukin 6 Homo sapiens 70-74 29486150-2 2018 Thus, recently we synthesized novel paullone-like scaffold, 5H-benzo [2, 3][1,4]oxazepino[5,6-b]indoles, where compounds 13a and 14a attenuated the growth of liver cancer specific Hep-G2 cells in vitro and formed stable binding complex with IL-6. paullone 36-44 interleukin 6 Homo sapiens 241-245 20715974-9 2010 In the fetal circulation, the addition of MgSO(4) resulted only in a nonstatistical significant tendency toward decreased IL-6 levels, when compared with the control group. mgso 42-46 interleukin 6 Homo sapiens 122-126 20715974-10 2010 Our findings indicate that the perfused preeclamptic placenta secretes increased levels of IL-6 into the fetal and the maternal circulations and that MgSO(4) may normalize these increased secreted IL-6 levels. mgso 150-154 interleukin 6 Homo sapiens 197-201 18989635-4 2008 Furthermore, we found that IL-6 elevation was not observed after the addition of bortezomib to any examined MM cells alone, but was noted in a case of bone marrow stromal cells (BMSCs) of macrophage origin alone or co-cultured with MM cells. Bortezomib 81-91 interleukin 6 Homo sapiens 27-31 29664082-5 2018 GSOUF skewed the monocyte plasticity towards the anti-inflammatory non-classical CD14+CD16++ monocytes and reduced the inflammatory competence of LPS-treated human primary monocytes diminishing TNF-alpha, IL-1beta, and IL-6 gene expression and secretion. gsouf 0-5 interleukin 6 Homo sapiens 219-223 20600219-11 2010 Thus, Ni/MALP-2 interactions involve multiple protein kinase pathways (ERK(1/2), p38, and PI3K) that modulate events downstream from the early accumulation of HIF-1alpha to promote IL-6 gene expression directly or secondarily, through COX-2-derived autocrine products like PGE(2). Prostaglandins E 273-276 interleukin 6 Homo sapiens 181-185 30911653-4 2018 Persistently high levels of TGF-beta1 or stimulation by inflammatory cytokines (interleukin-6 (IL-6)) induce peritoneal MMT, adhesion formation and fibrosis. mmt 120-123 interleukin 6 Homo sapiens 80-93 21328888-1 2010 The paper presents the results of studying the effect of 10% perfluorane (PF) emulsion intravenously injected 1-2 days before surgical treatment for rhegmatogenous retinal detachment on the levels of the cytokines IL-1beta, TNF-alpha, IL-6, and IL-4 in the serum and subretinal fluid of patients. perfluorane 61-72 interleukin 6 Homo sapiens 235-239 18691242-6 2008 The addition of ThyL-6-cultured supernatant supported the growth of human myeloma ILKM-3 cells, which require the presence of IL-6 in the culture medium for the maintenance of cell growth, suggesting that the secreted IL-6 from ThyL-6 cells was biologically active. thyl-6 16-22 interleukin 6 Homo sapiens 126-130 18691242-6 2008 The addition of ThyL-6-cultured supernatant supported the growth of human myeloma ILKM-3 cells, which require the presence of IL-6 in the culture medium for the maintenance of cell growth, suggesting that the secreted IL-6 from ThyL-6 cells was biologically active. thyl-6 16-22 interleukin 6 Homo sapiens 218-222 18632923-0 2008 Lipoteichoic acid synergizes with glycosphingolipids to potently stimulate secretion of interleukin-6 from human blood cells. lipoteichoic acid 0-17 interleukin 6 Homo sapiens 88-101 30911653-4 2018 Persistently high levels of TGF-beta1 or stimulation by inflammatory cytokines (interleukin-6 (IL-6)) induce peritoneal MMT, adhesion formation and fibrosis. mmt 120-123 interleukin 6 Homo sapiens 95-99 18777460-3 2008 We therefore asked whether endothelial cells have an effect on adrenal IL-6 generation and whether IL-6 mediates biosynthesis of aldosterone as is observed after exposure of adrenocortical cells to endothelial cell-conditioned medium (ECCM). Aldosterone 129-140 interleukin 6 Homo sapiens 99-103 20516073-4 2010 Although PGE(2) positively regulates IL-6 synthesis in chondrocytes, the underlying signaling pathway of shear-induced IL-6 expression remains unknown. Prostaglandins E 9-12 interleukin 6 Homo sapiens 37-41 29406582-4 2018 ADE normalized levels of interleukin (IL)-6, tumor necrosis factor-alpha, and IL-1beta were significantly higher for AD patients than controls, but there was greater overlap between the two groups than for complement proteins. Adenine 0-3 interleukin 6 Homo sapiens 25-43 20364347-11 2010 There was a trend (P = 0.06) for IL-6 to be elevated in the high compared to the low CHO condition. cho 85-88 interleukin 6 Homo sapiens 33-37 18545980-7 2008 Moreover, BzATP treatment upregulated both IL-6 mRNA and protein expression. BzATP 10-15 interleukin 6 Homo sapiens 43-47 29670468-8 2018 Results: SAA-stimulated levels of released IL-6, IL-8, and sVCAM-1 from HCAEC were significantly attenuated by methotrexate, fluvastatin, and etoricoxib. Methotrexate 111-123 interleukin 6 Homo sapiens 43-47 18058097-7 2008 RESULTS: Supernatant from Endo(T-sup) contained increased levels of PGE2, IL-6 and VEGF as compared to Endo(Media) and Endo(Epi-sup) controls. t-sup 31-36 interleukin 6 Homo sapiens 74-78 18451782-7 2008 Plasma IL-6 was positively correlated with glycerol released in response to isoproterenol (10(-5) to 10(-8) mol/l) by isolated SC (0.31 <or= r <or= 0.65, P<0.05) and OM (0.36 <or= r <or= 0.40, P<0.02) adipocytes, independent of menopausal status. Glycerol 43-51 interleukin 6 Homo sapiens 7-11 18451782-10 2008 OM adipocyte glycerol release in response to isoproterenol (10(-5) to 10(-8) mol/l) was higher in the subsample of women with elevated plasma IL-6 (P <or= 0.07). Glycerol 13-21 interleukin 6 Homo sapiens 142-146 18546154-6 2008 DCIP-selective antisense oligodeoxynucleotide inhibited the expression of TNF-alpha-responsive gene targets including vascular cell adhesion molecule-1, intercellular adhesion molecule-1, IL-6, IL-8, IP-10, and thymic stromal lymphopoietin. dcip 0-4 interleukin 6 Homo sapiens 188-192 20388727-8 2010 It is noteworthy that when the drugs were used in combination the effects of theophylline and salbutamol were additive in inhibiting TNF-alpha release, but theophylline blocked the IL-6-enhancing effect of salbutamol. Theophylline 156-168 interleukin 6 Homo sapiens 181-185 20441516-3 2010 Albendazole treatment, compared with placebo, was associated with significantly decreased plasma interleukin (IL) 10 levels (P = .01)ot associated with significant changes in levels of IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-12p70, IL-13, interferon gamma, tumor necrosis factor alpha, or thymic stromal lymphopoietin. Albendazole 0-11 interleukin 6 Homo sapiens 213-217 20231081-5 2010 GR function was measured by glucocorticoid inhibition of lypopolysaccharide (LPS)-stimulated interleukin-6 (IL-6) levels. lypopolysaccharide 57-75 interleukin 6 Homo sapiens 93-106 29670468-8 2018 Results: SAA-stimulated levels of released IL-6, IL-8, and sVCAM-1 from HCAEC were significantly attenuated by methotrexate, fluvastatin, and etoricoxib. Fluvastatin 125-136 interleukin 6 Homo sapiens 43-47 20231081-5 2010 GR function was measured by glucocorticoid inhibition of lypopolysaccharide (LPS)-stimulated interleukin-6 (IL-6) levels. lypopolysaccharide 57-75 interleukin 6 Homo sapiens 108-112 29670468-12 2018 Methotrexate showed strong beneficial effects for lowering released Il-6, IL-8, and sVCAM-1. Methotrexate 0-12 interleukin 6 Homo sapiens 68-72 18347604-8 2008 RESULTS: Infection of adipocytes with Ad-36, CMV and RSV resulted in increased IL-6 production from 192+/-22 pg ml(-1) (uninfected) to 1030+/-86 pg ml(-1), 838+/-59 pg ml(-1) and 1241+/-191 pg ml(-1), respectively (all P<0.01 vs control). Respiratory Syncytial Virus Vaccines 53-56 interleukin 6 Homo sapiens 79-83 29426287-8 2018 The preoperative IL-6 concentration in the preoperative RSB group was lower than that in the same group at the end of surgery and 24 h postoperatively. (1S,5S,6R)-10-(benzo[d]thiazol-6-ylsulfonyl)-5-(methoxymethyl)-3-(pyridin-2-ylethyl)-3,10-diazabicyclo[4.3.1]decan-2-one 56-59 interleukin 6 Homo sapiens 17-21 18316628-6 2008 Moreover, we demonstrated that NPI-0052 and bortezomib inhibited migration and adhesion in vitro and homing of WM cells in vivo, and overcame resistance induced by mesenchymal cells or by the addition of interleukin-6 in a coculture in vitro system. Bortezomib 44-54 interleukin 6 Homo sapiens 204-217 20200221-9 2010 IL-6 and IL-8 were also significantly elevated after exposure to diacetyl, glyoxal, and methyl glyoxal. Glyoxal 75-82 interleukin 6 Homo sapiens 0-4 20200221-9 2010 IL-6 and IL-8 were also significantly elevated after exposure to diacetyl, glyoxal, and methyl glyoxal. Glyoxal 95-102 interleukin 6 Homo sapiens 0-4 29426287-9 2018 CONCLUSIONS: We concluded that preoperative RSB might preserve postoperative sleep by inhibiting the increase of IL-6 without shortening the analgesia time compared with postoperative RSB in female patients undergoing elective midline incision transabdominal gynecological surgery. (1S,5S,6R)-10-(benzo[d]thiazol-6-ylsulfonyl)-5-(methoxymethyl)-3-(pyridin-2-ylethyl)-3,10-diazabicyclo[4.3.1]decan-2-one 44-47 interleukin 6 Homo sapiens 113-117 29204926-7 2018 Bupivacaine release profile analyses indicated that mode of drug delivery controlled the LA concentration over time and pathway analysis identified several shared and cytokine-specific molecular mediators for IL-6, PGE2, and TGF-beta1 which could explain differential MSC secretion responses in the presence of bupivacaine. Bupivacaine 311-322 interleukin 6 Homo sapiens 209-213 20463301-8 2010 In addition, WECG attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187-stimulated gene expression and secretion of proinflammatory cytokines such as tumor necrosis factor-alpha and interleukin-6 in human mast cells. wecg 13-17 interleukin 6 Homo sapiens 204-217 19892012-3 2010 Here, we show that COX-2/PGE(2)/IL-6 induction is dependent on Toll-like receptor 4 (TLR4)/NADPH oxidase signaling in human tracheal smooth muscle cells (HTSMCs). Prostaglandins E 25-28 interleukin 6 Homo sapiens 32-36 18389479-4 2008 DiC14-amidine liposomes also activated human DC, as shown by synthesis of IL-12p40 and TNF-alpha, accumulation of IL-6, IFN-beta and CXCL10 mRNA, and up-regulation of membrane expression of CD80 and CD86. N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine 0-13 interleukin 6 Homo sapiens 114-118 29348392-4 2018 The senescence-associated beta-galactosidase activity, the protein expression of P16 and P21, and inflammatory-related marker gene levels IL-1beta, IL-6, and TNF-alpha were increased in bleomycin-treated AFSCs in a dose-dependent manner. Bleomycin 186-195 interleukin 6 Homo sapiens 148-152 18327291-9 2008 PMMA-CHDF treatment improved both hypercytokinemia (assessed by measurement of blood IL-6 level) and dysoxia (assessed by measurement of blood lactate level). pmma-chdf 0-9 interleukin 6 Homo sapiens 85-89 21253500-7 2010 ELISA showed that KBG and paeoniflorin suppressed the production of MIF, IL-6, IL-8, and TNF-alpha in LPS-stimulated HDMECs. peoniflorin 26-38 interleukin 6 Homo sapiens 73-77 29348392-5 2018 Rapamycin treatment decreased the gene expression of MMP-3, MMP-13, IL-1beta, IL-6, TNF-alpha, and protein levels of P16 and P21 in bleomycin-treated AFSCs. Bleomycin 132-141 interleukin 6 Homo sapiens 78-82 18208411-6 2008 In accordance with the TLR expression levels, DCs generated from both AML patients and HVs responded to the known microbial ligands peptidoglycan (PGN) and lipoteichoic acid for TLR-2 and LPS as ligand for TLR-4, by producing TNF-alpha and IL-6. lipoteichoic acid 156-173 interleukin 6 Homo sapiens 240-244 29162324-5 2018 ABF strongly suppressed LPS-induced TNF-alpha, IL-6 and IL-10 secretion in M(GM-CSF)s, however in M(M-CSF)s only TNF-alpha was suppressed, with these cells secreting high levels of IL-10 which was not affected by ABF treatment. 4-Amino-7-nitrobenzofurazan 0-3 interleukin 6 Homo sapiens 47-51 18458677-0 2009 Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment. Ribavirin 138-147 interleukin 6 Homo sapiens 32-45 18005471-8 2008 The interleukins were significantly higher at some perioperative time points in the fentanyl group compared to the remifentanil group (tumour necrosis factor: T5: 3.57 vs. 2.37; IL-6: T5: 4.62 vs. 3.73; and IL-8: T5: 4.43 vs. 2.65 and T6: 2.61 vs. 1.13). Fentanyl 84-92 interleukin 6 Homo sapiens 178-182 19850345-8 2009 To understand whether the inhibitory effect of thymulin on cytokine release is cAMP-dependent, Forskolin, a labdane diterpene known to elevate intracellular cAMP, was shown to reduce the secretion of IL-1beta and TNF-alpha, but not IL-6, an effect mimicked by dibutyryl-cAMP (dbcAMP), an analog of cAMP. Colforsin 95-104 interleukin 6 Homo sapiens 232-236 28439952-10 2018 Higher levels of IL-6, IL-8 and TNF-alpha were found in cell supernatant after stimulation with multimethacrylate (Real Seal) compared to all other sealers tested (P < 0.05). multimethacrylate 96-113 interleukin 6 Homo sapiens 17-21 18177344-5 2008 SAPK/JNK-specific inhibitor SP600125 slightly suppressed IL-6 production although no evident effects were obtained for TNF-alpha and IL-1beta; ERK1/2 inhibitor PD98059 blocked both TNF-alpha and IL-1beta, but not IL-6 production. pyrazolanthrone 28-36 interleukin 6 Homo sapiens 57-61 18177344-5 2008 SAPK/JNK-specific inhibitor SP600125 slightly suppressed IL-6 production although no evident effects were obtained for TNF-alpha and IL-1beta; ERK1/2 inhibitor PD98059 blocked both TNF-alpha and IL-1beta, but not IL-6 production. pyrazolanthrone 28-36 interleukin 6 Homo sapiens 213-217 18720166-1 2008 Quercetin (QUER) and luteolin (LUTE) are dietary flavonoids capable of regulating the production of cytokines, such as tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6). Quercetin 0-9 interleukin 6 Homo sapiens 164-177 18720166-1 2008 Quercetin (QUER) and luteolin (LUTE) are dietary flavonoids capable of regulating the production of cytokines, such as tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6). Quercetin 0-9 interleukin 6 Homo sapiens 179-183 18720166-1 2008 Quercetin (QUER) and luteolin (LUTE) are dietary flavonoids capable of regulating the production of cytokines, such as tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6). Flavonoids 49-59 interleukin 6 Homo sapiens 164-177 18720166-1 2008 Quercetin (QUER) and luteolin (LUTE) are dietary flavonoids capable of regulating the production of cytokines, such as tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6). Flavonoids 49-59 interleukin 6 Homo sapiens 179-183 19692118-9 2009 Moreover, the coatings synthesized from hydroxyapatite at relatively high bisphosphonate content (7.1% wt) displayed a reduced production of Tumour Necrosis Factor alpha (TNF-alpha) and Interleukin 6 (IL-6), suggesting a down-regulatory role of alendronate on the inflammatory reaction. Diphosphonates 74-88 interleukin 6 Homo sapiens 186-199 19692118-9 2009 Moreover, the coatings synthesized from hydroxyapatite at relatively high bisphosphonate content (7.1% wt) displayed a reduced production of Tumour Necrosis Factor alpha (TNF-alpha) and Interleukin 6 (IL-6), suggesting a down-regulatory role of alendronate on the inflammatory reaction. Diphosphonates 74-88 interleukin 6 Homo sapiens 201-205 30272511-5 2018 Our results show that lipopolysaccharide (LPS), lipoteichoic acid (LTA) and peptidoglycan (PGN) significantly increase FN expression of macrophages; FN substantially enhances interleukin 6 (IL-6), tumor necrosis factor-alpha (TNFalpha), ras-related C3 botulinum toxin substrate 1/2 (Rac1/2), and cell division control protein 42 homolog (Cdc42) expression and phagocytosis of macrophages. lipoteichoic acid 48-65 interleukin 6 Homo sapiens 175-188 19726772-8 2009 Levels of total cholesterol, low-density lipoprotein cholesterol, interleukin-6, and C-reactive protein were significantly decreased in the fluvastatin group but were unchanged in the placebo group. Fluvastatin 140-151 interleukin 6 Homo sapiens 66-79 17785586-3 2007 Here we demonstrate that PPARgamma agonists 15-d-PGJ2 and troglitazone significantly suppress cell-cell adhesive events, including expression of adhesion molecules and IL-6 secretion from BMSCs triggered by adhesion of MM cells, as well as overcome drug resistance by a PPARgamma-dependent mechanism. Troglitazone 58-70 interleukin 6 Homo sapiens 168-172 18203069-9 2007 In addition, exposure to icodextrin-PDF impaired viability and IL-6 release from HPMC. Icodextrin 25-35 interleukin 6 Homo sapiens 63-67 19712481-9 2009 In addition, we show that BITC can prevent the induction of STAT3 activation by Interleukin-6 in MDA-MB-453 breast cancer cells. benzyl isothiocyanate 26-30 interleukin 6 Homo sapiens 80-93 30272511-5 2018 Our results show that lipopolysaccharide (LPS), lipoteichoic acid (LTA) and peptidoglycan (PGN) significantly increase FN expression of macrophages; FN substantially enhances interleukin 6 (IL-6), tumor necrosis factor-alpha (TNFalpha), ras-related C3 botulinum toxin substrate 1/2 (Rac1/2), and cell division control protein 42 homolog (Cdc42) expression and phagocytosis of macrophages. lipoteichoic acid 48-65 interleukin 6 Homo sapiens 190-194 19698236-5 2009 It is concluded that cis-elements including T-Ag, PU.1, c-Ets, XPF-1, P2 alphaA, IL6-6RE and RAR may inhibit lrp16 expression and hormone or its inhibitor such as corticosteroid, tamoxifen, forskolin, phenylephrine, inflammatory factors such as IL6, IFNgamma and TNFalpha, and chemotherapeutics 5-fluorouracil may participate in the regulation of lrp16 gene expression in negative manner. Phenylephrine 201-214 interleukin 6 Homo sapiens 245-248 30272511-5 2018 Our results show that lipopolysaccharide (LPS), lipoteichoic acid (LTA) and peptidoglycan (PGN) significantly increase FN expression of macrophages; FN substantially enhances interleukin 6 (IL-6), tumor necrosis factor-alpha (TNFalpha), ras-related C3 botulinum toxin substrate 1/2 (Rac1/2), and cell division control protein 42 homolog (Cdc42) expression and phagocytosis of macrophages. lipoteichoic acid 67-70 interleukin 6 Homo sapiens 175-188 30272511-5 2018 Our results show that lipopolysaccharide (LPS), lipoteichoic acid (LTA) and peptidoglycan (PGN) significantly increase FN expression of macrophages; FN substantially enhances interleukin 6 (IL-6), tumor necrosis factor-alpha (TNFalpha), ras-related C3 botulinum toxin substrate 1/2 (Rac1/2), and cell division control protein 42 homolog (Cdc42) expression and phagocytosis of macrophages. lipoteichoic acid 67-70 interleukin 6 Homo sapiens 190-194 17822789-9 2007 Furthermore, these HB-EGF-mediated up-regulation of IL-6 mRNA expression and secretion were inhibited by NF-kappaB inhibitor Bay117082 (2.5 microM) treatment suggesting involvement of NF-kappaB pathway. 3-(4-methylphenylsulfonyl)-2-propenenitrile 125-134 interleukin 6 Homo sapiens 52-56 17822789-10 2007 Again, the late activation of STAT3 by HB-EGF was abolished by both Bay117082 and IL-6 neutralizing antibody (1 microg/ml) indicating IL-6 is a key molecule in the delayed activation of STAT3 by HB-EGF. 3-(4-methylphenylsulfonyl)-2-propenenitrile 68-77 interleukin 6 Homo sapiens 134-138 28919508-5 2017 Interestingly, Ch/gamma-PGA NPs, prepared by co-acervation method, induced an immunostimulatory DCs phenotype, enhancing the expression of the co-stimulatory molecules CD86, CD40 and HLA-DR, and the secretion of the pro-inflammatory cytokines TNF-alpha, IL-12p40 and IL-6. poly(gamma-glutamic acid) 18-27 interleukin 6 Homo sapiens 267-271 17581928-11 2007 A pretreatment with SN50 or BAY 11-7082 also blocked the IL-6-induced increase in alpha-MG uptake. 3-(4-methylphenylsulfonyl)-2-propenenitrile 28-39 interleukin 6 Homo sapiens 57-61 17581928-11 2007 A pretreatment with SN50 or BAY 11-7082 also blocked the IL-6-induced increase in alpha-MG uptake. alpha-mg 82-90 interleukin 6 Homo sapiens 57-61 19409914-5 2009 To further examine the mechanism responsible for the inhibition of IL-6 production by 15d-PGJ(2), we examined the effect of 15d-PGJ(2) on nuclear factor-kappaB (NF-kappaB) activation and the phosphorylation of protein kinase B (Akt). 15d-pgj 86-93 interleukin 6 Homo sapiens 67-71 28671717-8 2017 In Tresp /Treg co-cultures, IL-4, IL-6 and IL-10 production increased in the presence of Treg in patients. treg 10-14 interleukin 6 Homo sapiens 34-38 19586571-7 2009 The concentrations of IL-6 in the culture supernatant were reduced by 88.8 and 92.3 % with 3,4-DHPPA and 3,4-DHPAA pre-treatment, respectively. 3,4-dihydroxyphenylpropionic acid 91-100 interleukin 6 Homo sapiens 22-26 19586571-7 2009 The concentrations of IL-6 in the culture supernatant were reduced by 88.8 and 92.3 % with 3,4-DHPPA and 3,4-DHPAA pre-treatment, respectively. 3,4-Dihydroxyphenylacetic Acid 105-114 interleukin 6 Homo sapiens 22-26 18229608-4 2007 In culture supernatants of TNF-alpha-stimulated HaCaT cells, production of IL-6 and TNF-alpha could be enhanced by lithium carbonate; production of IL-6 and a panel of cytokines and growth factors could be enhanced by propranolol hydrochloride; and IL-6 was up-regulated by chloroquine diphosphate as well. Lithium Carbonate 115-132 interleukin 6 Homo sapiens 75-79 28849160-4 2017 The results indicated that GBP and PGB suppressed the SP-induced production of IL-6, and IL-8 in U373 MG cells. Pregabalin 35-38 interleukin 6 Homo sapiens 79-83 17537833-0 2007 Interleukin-6 alters the cellular responsiveness to clopidogrel, irinotecan, and oseltamivir by suppressing the expression of carboxylesterases HCE1 and HCE2. Clopidogrel 52-63 interleukin 6 Homo sapiens 0-13 17537833-7 2007 In addition, pretreatment with IL-6 altered the cellular responsiveness in an opposite manner of overexpression of HCE1 and HCE2 toward various ester therapeutic agents (e.g., clopidogrel). Clopidogrel 176-187 interleukin 6 Homo sapiens 31-35 17617741-9 2007 Flutamide (Flu), an AR antagonist, completely abolished DHT-stimulated cell growth and the expression of IL-6 and IL-8. Flutamide 0-9 interleukin 6 Homo sapiens 105-109 17617741-9 2007 Flutamide (Flu), an AR antagonist, completely abolished DHT-stimulated cell growth and the expression of IL-6 and IL-8. Flutamide 0-3 interleukin 6 Homo sapiens 105-109 18575957-1 2009 Aim The present study sought insight into the effects of remifentanyl and fentanyl on LPS-induced release of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and IL-10 in human whole blood. Fentanyl 61-69 interleukin 6 Homo sapiens 109-122 18575957-6 2009 Conclusion Remifentanyl or fentanyl alone has no effects on IL-6, TNF-alpha and IL-10 production, but could attenuate LPS-induced IL-6,TNF-alpha and IL-10 production in human whole blood. Fentanyl 15-23 interleukin 6 Homo sapiens 130-134 18575957-7 2009 Remifentanyl and fentanyl could inhibit the expressions of IL-6, TNF-alpha and IL-10 induced by LPS. Fentanyl 4-12 interleukin 6 Homo sapiens 59-63 19118524-3 2009 In this study, we report that two synthetic FXR agonists, WAY-362450 and GW4064, suppressed interleukin-6-induced CRP expression in human Hep3B hepatoma cells. WAY-362450 58-68 interleukin 6 Homo sapiens 92-105 28849160-6 2017 Together, these observations suggest that GBP and PGB likely prevent SP-induced IL-6 and IL-8 production in U373 MG cells via the inhibition of signaling molecules, including p38 MAPK and NF-kappaB, thereby exhibiting antineuroinflammatory effects. Pregabalin 50-53 interleukin 6 Homo sapiens 80-84 29163489-7 2017 Finally, Curc-SPNs were shown to diminish up to 6.5-fold the production of pro-inflammatory cytokines-IL-1beta; IL-6, and TNF-alpha-in macrophages stimulated via amyloid-beta fibers. curc-spns 9-18 interleukin 6 Homo sapiens 112-116 19158563-8 2009 Tear IL-6 and IL-8 levels were significantly higher in patients with CCh than in controls (P <or= 0.001). 1-acetyl-2-(coumariniminecarboxamide-3-yl)hydrazine 69-72 interleukin 6 Homo sapiens 5-9 17577102-7 2007 Rosuvastatin inhibited the expressions of ICAM-1, MCP-1, IL-8, IL-6, and COX-2 mRNA and protein levels. Rosuvastatin Calcium 0-12 interleukin 6 Homo sapiens 63-67 29048388-7 2017 TAM count was significantly correlated with Treg count and with IL6-positive cancer cell count. tam 0-3 interleukin 6 Homo sapiens 64-67 17224841-4 2007 Polymethylmethacrylate elicited a six- to 12-fold increase in gene expression of tumor necrosis factor alpha, interleukin 1alpha, interleukin 1beta, interleukin 6, and interleukin 8 in purified monocytes and unfractionated peripheral blood mononuclear cells. Polymethyl Methacrylate 0-22 interleukin 6 Homo sapiens 149-162 19014338-9 2009 Elevated IL-6 levels and reductions in IL-6 levels early in treatment may reflect ultimate clinical response to docetaxel-based regimens. Docetaxel 112-121 interleukin 6 Homo sapiens 9-13 19014338-9 2009 Elevated IL-6 levels and reductions in IL-6 levels early in treatment may reflect ultimate clinical response to docetaxel-based regimens. Docetaxel 112-121 interleukin 6 Homo sapiens 39-43 19641312-4 2009 RESULTS: An increase in IL-6 level was found in the aspirin group when compared to the triflusal group at the third and seventh day (p < 0.05). triflusal 87-96 interleukin 6 Homo sapiens 24-28 28823947-14 2017 At Day 14, relative to placebo, sputum interleukin (IL)-8 and IL-6 levels were reduced on average by 32% and 29% respectively after inhalation of GSK2269557 1000 mug in Part A. gsk2269557 146-156 interleukin 6 Homo sapiens 62-66 19641312-9 2009 CONCLUSION: Triflusal modulates additional mechanisms to those of aspirin [pro-inflammatory (IL-6) and chemokine (MIP-1 and MCP-1) pathways] that could participate in the ischemic damage process following human acute stroke. triflusal 12-21 interleukin 6 Homo sapiens 93-97 19688109-6 2009 Interestingly, inhibition of leptin-induced NO production with a selective iNOS inhibitor 1400 W inhibited also the production of IL-6, IL-8, and PGE(2), and this was reversed by exogenously added NO-donor SNAP, suggesting that the effects of leptin on IL-6, IL-8, and PGE(2) production are dependent on NO. Prostaglandins E 269-272 interleukin 6 Homo sapiens 130-134 17461989-0 2007 The PPARdelta agonist GW501516 suppresses interleukin-6-mediated hepatocyte acute phase reaction via STAT3 inhibition. GW 501516 22-30 interleukin 6 Homo sapiens 42-55 17461989-3 2007 MATERIALS AND METHODS: We examined the ability of the synthetic PPARdelta agonist GW501516 to suppress interleukin-6-induced expression of acute phase proteins in human hepatoma HepG2 cells and rat primary hepatocytes. GW 501516 82-90 interleukin 6 Homo sapiens 103-116 17461989-4 2007 Results GW501516 dose-dependently suppressed interleukin-6-induced mRNA expression of the acute phase protein alpha1-antichymotrypsin in HepG2 cells. GW 501516 8-16 interleukin 6 Homo sapiens 45-58 19383353-7 2008 In a combination treatment with curcumin and bortezomib, IL-6/sIL-6R-induced STAT3 and Erk phosphorylation was effectively inhibited. Bortezomib 45-55 interleukin 6 Homo sapiens 57-61 28823947-17 2017 Moreover, inhalation of GSK2269557 resulted in suppression of sputum IL-8 and IL-6 levels, consistent with the known anti-inflammatory activity of a PI3Kdelta inhibitor. gsk2269557 24-34 interleukin 6 Homo sapiens 78-82 17588137-5 2007 RESULTS: Quercetin decreased the gene expression and production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8 in PMACI-stimulated HMC-1 cells. Quercetin 9-18 interleukin 6 Homo sapiens 126-130 29026320-0 2017 Quercetin inhibits epithelial-mesenchymal transition, decreases invasiveness and metastasis, and reverses IL-6 induced epithelial-mesenchymal transition, expression of MMP by inhibiting STAT3 signaling in pancreatic cancer cells. Quercetin 0-9 interleukin 6 Homo sapiens 106-110 17321112-9 2007 Protein kinase C (PKC) activation by phorbol myristate acetate (PMA) potentiated IL-6 mRNA expression, whereas PKC inhibition by bisindolylmaleimide blocked SPC-induced p42/44 ERK phosphorylation and IL-6 expression. bisindolylmaleimide 129-148 interleukin 6 Homo sapiens 200-204 19084961-7 2008 Either Pg-LPS or E-LPS stimulated HGF-1 or THP-1 cells to continuously increase the secretion of IL-6 (P<0.01). pg-lps 7-13 interleukin 6 Homo sapiens 97-101 29026320-8 2017 As expected, the EMT and MMP secretion increased with activation of the STAT3 signaling pathway, and quercetin reversed IL-6-induced EMT, invasion, and migration. Quercetin 101-110 interleukin 6 Homo sapiens 120-124 17185492-8 2007 IL-6 is a cytokine that may have beneficial systemic effects by mobilizing glucose from the liver and free fatty acids from the adipose tissue and providing them to the strenuously working respiratory muscles. Fatty Acids, Nonesterified 102-118 interleukin 6 Homo sapiens 0-4 18586117-3 2008 Increased levels of circulating pro-inflammatory cytokines, such as TNF-alpha, IL-1beta, IL-12p70, and IL-6 have been observed in most of patients with CIU, together with an enhancement of IL-2 secretion following T-cell stimulation. n-cyclohexyl-n'-(4-iodophenyl)urea 152-155 interleukin 6 Homo sapiens 103-107 28878677-4 2017 Our results showed that Teuvincenone F attenuated K63-linked ubiquitination of NF-kappaB-essential modulator (NEMO, also known as IKKgamma) to suppress LPS-induced phosphorylation of NF-kappaB, and inhibited mRNA expression of IL-1beta, IL-6, TNF-alpha, and NLRP3. teuvincenone 24-36 interleukin 6 Homo sapiens 237-241 18690088-0 2008 Blockage of interleukin-6 signaling with 6-amino-4-quinazoline synergistically induces the inhibitory effect of bortezomib in human U266 cells. Bortezomib 112-122 interleukin 6 Homo sapiens 12-25 18690088-7 2008 Furthermore, combined treatment with bortezomib and 6-amino-4-quinazoline effectively inhibited the IL-6 and soluble IL-6R-induced activation of STAT3 and extracellular signal-regulated kinase phosphorylation. Bortezomib 37-47 interleukin 6 Homo sapiens 100-104 18267100-4 2008 Dihydrocaffeic acid reduced the cytotoxicity and pro-inflammatory cytokine production (interleukin-6 and -8) in HaCaT cells, a keratinocyte model, following UV radiation. 3,4-dihydroxyphenylpropionic acid 0-19 interleukin 6 Homo sapiens 87-107 17418729-9 2007 Serum IL-6 and IL-10 concentrations increased after CPB when compared to the preoperative concentration. cpb 52-55 interleukin 6 Homo sapiens 6-10 17418729-11 2007 The IL-10 to IL-6 ratio was lower in the HLHS group preoperatively and immediately after CPB. cpb 89-92 interleukin 6 Homo sapiens 13-17 29109769-6 2017 DCZ3301 retained its activity against MM cells in the presence of exogenous cytokines (IL-6 or VEGF) or bone marrow stromal cells (BMSCs) and reduced activity of multiple signaling pathways (STAT3, NFkappaB, AKT, ERK1/2) in MM but not normal cells. DCZ3301 0-7 interleukin 6 Homo sapiens 87-91 16820206-4 2007 We present here the first case in the literature with MDS/MPD syndrome, sole 5q- anomaly and thrombocytosis in which bortezomib administration normalized platelet count, produced a major erythroid response, and reduced levels of interleukin-6 (IL-6) and TNF-alpha while increased levels of IL-4 in the bone marrow plasma. Bortezomib 117-127 interleukin 6 Homo sapiens 229-242 16820206-4 2007 We present here the first case in the literature with MDS/MPD syndrome, sole 5q- anomaly and thrombocytosis in which bortezomib administration normalized platelet count, produced a major erythroid response, and reduced levels of interleukin-6 (IL-6) and TNF-alpha while increased levels of IL-4 in the bone marrow plasma. Bortezomib 117-127 interleukin 6 Homo sapiens 244-248 18606639-7 2008 DXS also inhibits the functional maturation of DC as demonstrated by reduced T cell proliferation, and strongly impairs secretion of the proinflammatory mediators IL-1beta, IL-6, IL-12p70, and TNF-alpha. Dextran Sulfate 0-3 interleukin 6 Homo sapiens 173-177 28474156-13 2017 JNK inhibitor SP600125 reduced JNK phosphorylation, downregulated cleaved caspase-3 protein level, decreased AP-1 transcriptional activity and ROS level, and reduced the transcription and expression of TNF-alpha and IL-6, which improved ALI and cell apoptosis after paraquat poisoning. pyrazolanthrone 14-22 interleukin 6 Homo sapiens 216-220 18191862-3 2008 We examined whether C-reactive protein (CRP) and interleukin-6 (IL-6) are independently associated with DTAC. dodecyltrimethylammonium 104-108 interleukin 6 Homo sapiens 64-68 16860297-7 2007 Exposure to the photochemically generated products of BD (primarily acrolein, acetaldehyde, formaldehyde, furan and ozone) induced significant increases in cytotoxicity, IL-8, and IL-6 gene expression compared to a synthetic mixture of primary products that was created by injecting the correct concentrations of the detected products from the irradiation experiments. furan 106-111 interleukin 6 Homo sapiens 180-184 28829844-8 2017 Stabilization of DHFR-IkappaBalpha with TMP prevented IL-1alpha-, A2E-, LPS-, and TNFalpha-induced NFkappaB-mediated upregulation and release of the proinflammatory cytokines IL-1beta and IL-6 from ARPE-19 cells (by as much as 93%). Trimethoprim 40-43 interleukin 6 Homo sapiens 188-192 17621556-3 2007 Here, we report that, at concentrations that did not induce whole blood cytokine production when tested separately, (1-->3)-beta-D-glucans powerfully co-stimulated cytokine production (IL-6/IL-8) induced by ligands for TLR1/2, TLR2/6, TLR4, and TLR5. beta-D-Glucan 127-141 interleukin 6 Homo sapiens 188-192 18191862-8 2008 Participants with DTAC had significantly higher levels of both CRP and IL-6. dodecyltrimethylammonium 18-22 interleukin 6 Homo sapiens 71-75 18191862-10 2008 CONCLUSIONS: IL-6, a systemic inflammatory marker, is related to the presence and extent of DTAC. dodecyltrimethylammonium 92-96 interleukin 6 Homo sapiens 13-17 28637505-7 2017 Salmeterol and formoterol exerted an inhibitory effect on the LPS-induced production of TNF-alpha, IL-6, CCL2, CCL3, and CCL4 in MDMs. Salmeterol Xinafoate 0-10 interleukin 6 Homo sapiens 99-103 18305954-0 2008 Effects of allicin supplementation on plasma markers of exercise-induced muscle damage, IL-6 and antioxidant capacity. allicin 11-18 interleukin 6 Homo sapiens 88-92 18958706-0 2006 Greater than additive suppression of TLR3-induced IL-6 responses by administration of dieldrin and atrazine. Dieldrin 86-94 interleukin 6 Homo sapiens 50-54 18958706-6 2006 Subcutaneous administration of dieldrin (10-20 mg/kg, daily for 7 d) and atrazine (one dose on Day 7, 100-200 mg/kg) inhibited the production of IL-6 and IL-12 in the peritoneal cavity in a dose-dependent manner, but IL-10 was either increased or not affected. Dieldrin 31-39 interleukin 6 Homo sapiens 145-149 18958706-8 2006 However, at lower dosages of both compounds (10 mg/kg dieldrin and 50 mg/kg atrazine), the effect was much greater than additive on IL-6 production (adding the individual effects of atrazine and dieldrin on IL-6 production indicates 20% suppression, whereas the combination yields 80% suppression) and essentially additive for inhibition of the activation of c-JUN (a component of the transcription factor, AP-1). Dieldrin 195-203 interleukin 6 Homo sapiens 207-211 18958706-11 2006 Dieldrin and atrazine administered orally (as opposed to subcutaneously as in the other experiments) also effectively suppressed IL-6 production. Dieldrin 0-8 interleukin 6 Homo sapiens 129-133 18443271-0 2008 The effect of azacitidine on interleukin-6 signaling and nuclear factor-kappaB activation and its in vitro and in vivo activity against multiple myeloma. Azacitidine 14-25 interleukin 6 Homo sapiens 29-42 28730070-8 2017 Various signal pathway inhibitors, including SP600125 (JNK inhibitor), SB203580 (p38 MAPK inhibitor) and BAY11-7082 (NF-kappaB inhibitor) significantly decreased the UVB-induced secretion of IL-6 and IL-8 secretion (P<0.05). pyrazolanthrone 45-53 interleukin 6 Homo sapiens 191-195 28730070-8 2017 Various signal pathway inhibitors, including SP600125 (JNK inhibitor), SB203580 (p38 MAPK inhibitor) and BAY11-7082 (NF-kappaB inhibitor) significantly decreased the UVB-induced secretion of IL-6 and IL-8 secretion (P<0.05). 3-(4-methylphenylsulfonyl)-2-propenenitrile 105-115 interleukin 6 Homo sapiens 191-195 16989825-0 2006 Decreased suppression of interleukin-6 after treatment with medroxyprogesterone acetate and danazol in endometrial stromal cells of women with adenomyosis. Medroxyprogesterone Acetate 60-87 interleukin 6 Homo sapiens 25-38 27722854-9 2017 CONCLUSIONS: Sarilumab treatment resulted in a reduction in exposure of simvastatin, consistent with reversal of IL-6-mediated CYP3A4 suppression in patients with active RA, as was reported for tocilizumab with simvastatin and for sirukumab with midazolam. Midazolam 246-255 interleukin 6 Homo sapiens 113-117 16989825-9 2006 CONCLUSION(S): Medroxyprogesterone acetate and danazol appeared to have a decreased effect on the suppression of IL-6 liberated by ESCs in adenomyosis. Medroxyprogesterone Acetate 15-42 interleukin 6 Homo sapiens 113-117 17065510-0 2006 Triamcinolone acetonide inhibits IL-6- and VEGF-induced angiogenesis downstream of the IL-6 and VEGF receptors. Triamcinolone Acetonide 0-23 interleukin 6 Homo sapiens 33-91 17065510-1 2006 PURPOSE: To test whether triamcinolone acetonide (TA) inhibits angiogenesis induced by IL-6 or VEGF and whether this inhibition is through antagonism of the IL-6 or the VEGF receptor 2. Triamcinolone Acetonide 50-52 interleukin 6 Homo sapiens 87-91 17065510-11 2006 TA inhibits IL-6-induced STAT3 expression in cornea, but it does not inhibit activation of the IL-6 or the VEGF receptor in cultured human endothelial cells. Triamcinolone Acetonide 0-2 interleukin 6 Homo sapiens 12-16 18312445-9 2008 Resting levels of IL-6 and TNF-alpha and exercise-induced peak variations of TBARS, IL-6 and TNF-alpha were negatively correlated with the baseline PaO2. pao2 148-152 interleukin 6 Homo sapiens 18-22 18312445-9 2008 Resting levels of IL-6 and TNF-alpha and exercise-induced peak variations of TBARS, IL-6 and TNF-alpha were negatively correlated with the baseline PaO2. pao2 148-152 interleukin 6 Homo sapiens 84-88 18400717-7 2008 RESULTS: In Caco-2 cells, IL-6 secretion was significantly decreased by troglitazone, DHA, EPA, and GLA. Troglitazone 72-84 interleukin 6 Homo sapiens 26-30 16434095-5 2006 Treatment of placenta, amnion and choriodecidua with both 15d-PGJ(2) and troglitazone decreased basal and LPS-stimulated IL-1beta, IL-6, IL-10 and TNF-alpha release. 15d-pgj 58-65 interleukin 6 Homo sapiens 131-135 16434095-5 2006 Treatment of placenta, amnion and choriodecidua with both 15d-PGJ(2) and troglitazone decreased basal and LPS-stimulated IL-1beta, IL-6, IL-10 and TNF-alpha release. Troglitazone 73-85 interleukin 6 Homo sapiens 131-135 28474507-6 2017 The effect of TAK1 inhibitor 5Z-7-oxozeaenol and NF-kappaB inhibitor BAY 11-7082 on the expression of IL-6 was investigated. 3-(4-methylphenylsulfonyl)-2-propenenitrile 69-80 interleukin 6 Homo sapiens 102-106 18297698-2 2008 This study was undertaken to determine whether SK, either alone or in combination with quercitin (QT) is able to modulate the release of IL-6 and IL-8 from peripheral blood mononuclear cells (PBMCs). Quercetin 87-96 interleukin 6 Homo sapiens 137-141 18297698-2 2008 This study was undertaken to determine whether SK, either alone or in combination with quercitin (QT) is able to modulate the release of IL-6 and IL-8 from peripheral blood mononuclear cells (PBMCs). Quercetin 98-100 interleukin 6 Homo sapiens 137-141 16818766-3 2006 In this study, we evaluated the modulating effect of PGE(2) on STAT signaling and its biological function induced by IL-10 and IL-6, and elucidated its mechanism in THP-1 cells. Prostaglandins E 53-56 interleukin 6 Homo sapiens 127-131 28474507-11 2017 Both 5Z-7-oxozeaenol and BAY 11-7082 significantly inhibited IL-17F-induced IL-6 production in a dose-dependent manner. 5-7-oxo-zeaenol 5-20 interleukin 6 Homo sapiens 76-80 16818766-6 2006 In contrast, PGE(2) suppressed IL-6-induced phosphorylation of STAT3 and STAT1. Prostaglandins E 13-17 interleukin 6 Homo sapiens 31-35 18187519-4 2008 DNP treatment of the human THP-1 macrophage cell line resulted in reduced ATP synthesis, and, although hyporesponsive to LPS, the metabolically stressed macrophages produced IL-1beta, IL-6, and TNF-alpha. Dinitrophenols 0-3 interleukin 6 Homo sapiens 184-188 28474507-11 2017 Both 5Z-7-oxozeaenol and BAY 11-7082 significantly inhibited IL-17F-induced IL-6 production in a dose-dependent manner. 3-(4-methylphenylsulfonyl)-2-propenenitrile 25-36 interleukin 6 Homo sapiens 76-80 28240768-5 2017 KEY RESULTS: In the CFA model, eucalyptol strongly attenuated oedema and mechanical allodynia and reduced levels of inflammatory cytokines (IL-1beta, TNF-alpha and IL-6), effects comparable with those of ibuprofen. Eucalyptol 31-41 interleukin 6 Homo sapiens 164-168 18348080-0 2008 High omega-3 fat intake improves insulin sensitivity and reduces CRP and IL6, but does not affect other endocrine axes in healthy older adults. omega-3 fat 5-16 interleukin 6 Homo sapiens 73-76 16834785-7 2006 Inhibition of JNK by small molecule inhibitor SP600125 reduced pneumococci-induced IL-8 mRNA expression and release of IL-8 and IL-6. pyrazolanthrone 46-54 interleukin 6 Homo sapiens 128-132 28189222-0 2017 Acemannan increases NF-kappaB/DNA binding and IL-6/-8 expression by selectively binding Toll-like receptor-5 in human gingival fibroblasts. acemannan 0-9 interleukin 6 Homo sapiens 46-53 16713438-6 2006 In contrast, gliclazide significantly reduced lipopolysaccharide-stimulated macrophage tumor necrosis factor alpha and interleukin 6 secretion (P<.05). Gliclazide 13-23 interleukin 6 Homo sapiens 119-132 17906687-4 2008 PPAR-gamma receptor activation by TZDs improves insulin sensitivity by promoting fatty acid uptake into adipose tissue, increasing production of adiponectin and reducing levels of inflammatory mediators such as tumour necrosis factor-alpha (TNF-alpha), plasminogen activator inhibitor-1(PAI-1) and interleukin-6 (IL-6). Thiazolidinediones 34-38 interleukin 6 Homo sapiens 298-311 17906687-4 2008 PPAR-gamma receptor activation by TZDs improves insulin sensitivity by promoting fatty acid uptake into adipose tissue, increasing production of adiponectin and reducing levels of inflammatory mediators such as tumour necrosis factor-alpha (TNF-alpha), plasminogen activator inhibitor-1(PAI-1) and interleukin-6 (IL-6). Thiazolidinediones 34-38 interleukin 6 Homo sapiens 313-317 28189222-2 2017 We investigated whether acemannan induces IL-6 and -8 expression and NF-kappaB/DNA binding in human gingival fibroblasts. acemannan 24-33 interleukin 6 Homo sapiens 42-53 18386641-6 2008 RESULTS: Compared with control group, plasma ET at T2, serum IL-6 at T1 S100beta at T1 and T4 in TAES group all decreased significantly (P < 0.01, 0.05), while serum IL-6 at T3 increased remarkably (P < 0.05). taes 97-101 interleukin 6 Homo sapiens 61-65 16122789-7 2006 Treatment of cells with BAY 11-7082 at 50 microM significantly inhibited basal, LPS- and TNF-alpha-induced NF-kappaB and COX-2 expression, and IL-6 and PGF2alpha release. 3-(4-methylphenylsulfonyl)-2-propenenitrile 24-35 interleukin 6 Homo sapiens 143-147 28189222-7 2017 We found that acemannan significantly stimulated IL-6/-8 expression at both the mRNA and protein level and significantly increased p50/DNA binding. acemannan 14-23 interleukin 6 Homo sapiens 49-53 18386641-6 2008 RESULTS: Compared with control group, plasma ET at T2, serum IL-6 at T1 S100beta at T1 and T4 in TAES group all decreased significantly (P < 0.01, 0.05), while serum IL-6 at T3 increased remarkably (P < 0.05). taes 97-101 interleukin 6 Homo sapiens 169-173 18386641-9 2008 CONCLUSION: TAES can regulate plasma CGRP/ET and serum IL-6, lower serum S100beta level, which may contribute to its effect in relieving craniotomy-induced brain injury. taes 12-16 interleukin 6 Homo sapiens 55-59 28189222-8 2017 Preincubation with an anti-TLR5 neutralizing antibody abolished acemannan-induced IL-6/-8 expression and p50/DNA binding, and co-incubation of acemannan with Bay11-7082, a specific NF- kappaB inhibitor, abolished IL-6/-8 expression. acemannan 64-73 interleukin 6 Homo sapiens 82-89 28189222-8 2017 Preincubation with an anti-TLR5 neutralizing antibody abolished acemannan-induced IL-6/-8 expression and p50/DNA binding, and co-incubation of acemannan with Bay11-7082, a specific NF- kappaB inhibitor, abolished IL-6/-8 expression. acemannan 64-73 interleukin 6 Homo sapiens 82-86 16084689-7 2006 Nocturnal IL-6 secretion was significantly increased (p<.05) in insomniac patients for the whole measurement period (mean area under the curve+/-SD: 27.94+/-14.15 pg/ml x 2h) compared to controls (16.70+/-7.64 pg/ml x 2h). Deuterium 174-176 interleukin 6 Homo sapiens 10-14 28189222-10 2017 We conclude that acemannan induces IL-6/-8 expression, and p50/DNA binding in gingival fibroblasts, at least partly, via a TLR5/NF-kappaB-dependent signaling pathway. acemannan 17-26 interleukin 6 Homo sapiens 35-42 16084689-7 2006 Nocturnal IL-6 secretion was significantly increased (p<.05) in insomniac patients for the whole measurement period (mean area under the curve+/-SD: 27.94+/-14.15 pg/ml x 2h) compared to controls (16.70+/-7.64 pg/ml x 2h). Deuterium 221-223 interleukin 6 Homo sapiens 10-14 18173754-4 2008 Combination of ATO and p38 MAPK inhibition abolished the interleukin-6 enhanced protection of myeloma cells against ATO treatment. Arsenic Trioxide 15-18 interleukin 6 Homo sapiens 57-70 28211306-0 2017 Ex vivo all-trans retinoic acid modulates NO production and regulates IL-6 effect during rheumatoid arthritis: a study in Algerian patients. 2-octenal 12-17 interleukin 6 Homo sapiens 70-74 18789009-6 2008 Treatment with rosuvastatin in moderate doses significantly suppressed activity of endogenous inflammation and oxidative stress by way of activation of antioxidant system of plasma, decrease of oxidation of fractions of lipoproteins, suppression of " nitrotirosine " stress, as well as partial inhibition of efficacy of action of secretory phospholipase A2, lowering of content of C-reactive protein and interleukin-6. Rosuvastatin Calcium 15-27 interleukin 6 Homo sapiens 404-417 32454590-9 2017 By using cyclic adenosine monophosphate (cAMP)-arising reagent forskolin, cAMP is found to be involved in the up-regulation of IL-6 induction. Colforsin 63-72 interleukin 6 Homo sapiens 127-131 18540202-1 2008 The aim of the present study was to estimate the absorption of 125I-labeled proinflammatory cytokines--interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) from inflamed porcine uterus into the uterine venous blood. Iodine-125 63-67 interleukin 6 Homo sapiens 133-146 18540202-1 2008 The aim of the present study was to estimate the absorption of 125I-labeled proinflammatory cytokines--interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) from inflamed porcine uterus into the uterine venous blood. Iodine-125 63-67 interleukin 6 Homo sapiens 148-152 16532021-5 2006 We also investigated the effect of the flavonol quercetin that was recently shown to strongly inhibit IL-6 secretion in response to allergic stimulation from hCBMCs.IL-1 stimulated p38, but did not activate extracellular signal-regulated kinase (ERK) or c-jun N-terminal kinase (JNK); it also did not activate protein kinase C (PKC) isozymes alpha, beta, mu and zeta, except for PKC-theta, which was phosphorylated. Quercetin 48-57 interleukin 6 Homo sapiens 102-106 16532021-8 2006 These results indicate that IL-1-stimulated IL-6 production from human mast cells is regulated by biochemical pathways distinct from IgE-induced degranulation and that quercetin can block both IL-6 secretion and two key signal transduction steps involved. Quercetin 168-177 interleukin 6 Homo sapiens 44-48 16532021-8 2006 These results indicate that IL-1-stimulated IL-6 production from human mast cells is regulated by biochemical pathways distinct from IgE-induced degranulation and that quercetin can block both IL-6 secretion and two key signal transduction steps involved. Quercetin 168-177 interleukin 6 Homo sapiens 193-197 27655254-7 2017 LPS-induced upregulation of IL-1alpha/beta, IL-6 and TNF-alpha was also diminished by the TGR5-ligands allopregnanolone and taurolithocholic acid in mono-cultured microglia. Pregnanolone 103-119 interleukin 6 Homo sapiens 44-48 16799214-2 2006 The high concentration of IL-6 has implication in the pathology of some diseases especially in DHF/DSS patients. dhf 95-98 interleukin 6 Homo sapiens 26-30 18569918-9 2008 Similarly, the serum marker of osteoclastic activity beta-CTx was related inversely to patients" age (r = -0.383, p = -0.028), CRP (rho = -0.466, p = 0.006), and IL-6 (r = -0.460, p = 0.007) but positively to iPTH (r = 0.657, p < 0.001). beta-ctx 53-61 interleukin 6 Homo sapiens 162-166 28612530-8 2017 Minocycline significantly decreased the expressions of IL-1beta, IL-6 and A2AR and the number of CD11b-positive cells in peri-infarct region. Minocycline 0-11 interleukin 6 Homo sapiens 65-69 18053242-9 2007 In addition, donor and CP PBMC significantly induced an increase in IL-6, MCP-1 and TGFbeta levels under coculture conditions. cp pbmc 23-30 interleukin 6 Homo sapiens 68-72 16112536-3 2006 IL-1beta upregulates IL-6 via PGE(2), and via NF-kappaB, a transcription factor for many inflammatory mediator genes. Prostaglandins E 30-33 interleukin 6 Homo sapiens 21-25 16472586-11 2006 A similar relationship existed between the deltaACTH/deltacortisol ratio and the IL-6 levels. deltacortisol 53-66 interleukin 6 Homo sapiens 81-85 27739345-0 2017 Rosuvastatin Inhibits Interleukin (IL)-8 and IL-6 Production in Human Coronary Artery Endothelial Cells Stimulated With Aggregatibacter actinomycetemcomitans Serotype b. Rosuvastatin Calcium 0-12 interleukin 6 Homo sapiens 45-49 17975159-0 2007 Inhibition of interleukin-6 signaling with CNTO 328 enhances the activity of bortezomib in preclinical models of multiple myeloma. Bortezomib 77-87 interleukin 6 Homo sapiens 14-27 17975159-2 2007 We hypothesized that down-regulation of interleukin-6 (IL-6) signaling using the monoclonal antibody CNTO 328 would enhance the antitumor activity of the proteasome inhibitor bortezomib in multiple myeloma by attenuating inducible chemoresistance. Bortezomib 175-185 interleukin 6 Homo sapiens 40-53 17975159-2 2007 We hypothesized that down-regulation of interleukin-6 (IL-6) signaling using the monoclonal antibody CNTO 328 would enhance the antitumor activity of the proteasome inhibitor bortezomib in multiple myeloma by attenuating inducible chemoresistance. Bortezomib 175-185 interleukin 6 Homo sapiens 55-59 17975159-3 2007 EXPERIMENTAL DESIGN: The cytotoxicity of bortezomib, CNTO 328, and the combination, along with the associated molecular changes, was assessed in IL-6-dependent and IL-6-independent multiple myeloma cell lines, both in suspension and in the presence of bone marrow stromal cells and in patient-derived myeloma samples. Bortezomib 41-51 interleukin 6 Homo sapiens 145-149 17975159-3 2007 EXPERIMENTAL DESIGN: The cytotoxicity of bortezomib, CNTO 328, and the combination, along with the associated molecular changes, was assessed in IL-6-dependent and IL-6-independent multiple myeloma cell lines, both in suspension and in the presence of bone marrow stromal cells and in patient-derived myeloma samples. Bortezomib 41-51 interleukin 6 Homo sapiens 164-168 16393986-3 2006 We demonstrate in this study that PTX-B profoundly inhibits HIV expression in chronically infected promonocytic U1 cells stimulated with several cytokines and, particularly, the IL-6-mediated effect, a cytokine that triggers viral production in these cells independently of NF-kappaB activation. pumiliotoxin B 34-39 interleukin 6 Homo sapiens 178-182 16393986-7 2006 PTX-B inhibited IL-6-induced HIV-1 long-terminal repeat-driven transcription from A, C, E, and F viral subtypes, which contain functional AP-1 binding sites, but failed to inhibit transcription from subtypes B and D LTR devoid of these sites. pumiliotoxin B 0-5 interleukin 6 Homo sapiens 16-20 17975159-4 2007 RESULTS: Treatment of IL-6-dependent and IL-6-independent multiple myeloma cell lines with CNTO 328 enhanced the cytotoxicity of bortezomib in a sequence-dependent fashion. Bortezomib 129-139 interleukin 6 Homo sapiens 22-26 27739345-9 2017 Aa-induced IL-6 and IL-8 production was inhibited by rosuvastatin, particularly at higher doses. Rosuvastatin Calcium 53-65 interleukin 6 Homo sapiens 11-15 17975159-4 2007 RESULTS: Treatment of IL-6-dependent and IL-6-independent multiple myeloma cell lines with CNTO 328 enhanced the cytotoxicity of bortezomib in a sequence-dependent fashion. Bortezomib 129-139 interleukin 6 Homo sapiens 41-45 16393986-8 2006 In addition, PTX-B inhibited the secretion of IL-6-induced, AP-1-dependent genes, including urokinase-type plasminogen activator, CXCL8/IL-8, and CCL2/monocyte chemotactic protein-1. pumiliotoxin B 13-18 interleukin 6 Homo sapiens 46-50 27739345-10 2017 Interestingly, reduced IL-6 and IL-8 levels were observed in HCAECs stimulated with Aa in the presence of higher concentrations of rosuvastatin. Rosuvastatin Calcium 131-143 interleukin 6 Homo sapiens 23-27 28270081-15 2017 CONCLUSIONS: Our results support the potential role of 99mTc-HYNIC-Tocilizumb as a novel MM radiotracer for targeting IL-6 expression in-vivo. tocilizumb 67-77 interleukin 6 Homo sapiens 118-122 16983933-14 2006 In this patient, rapid increases in IL-6, D/P Cr and macromolecular and small molecular D/P by PET were noted after the change to icodextrin solution. Icodextrin 130-140 interleukin 6 Homo sapiens 36-40 17595889-0 2007 Rosuvastatin reduces interleukin-6-induced expression of C-reactive protein in human hepatocytes in a STAT3- and C/EBP-dependent fashion. Rosuvastatin Calcium 0-12 interleukin 6 Homo sapiens 21-34 17595889-3 2007 METHODS: Interleukin 6 (IL-6) stimulated human hepatoma cells (Hep3B) and primary human hepatocytes (PHH) were incubated with various concentrations of rosuvastatin (0.3 - 1 microM) for 24 hours. Rosuvastatin Calcium 152-164 interleukin 6 Homo sapiens 24-28 17595889-12 2007 CONCLUSIONS: Our results show a direct inhibitory effect of rosuvastatin on IL-6-induced expression of CRP in liver cells. Rosuvastatin Calcium 60-72 interleukin 6 Homo sapiens 76-80 29253845-12 2017 PAI-1 treatment increased the expression of TAM-associated cytokines and chemokines, including CCL-17, CCL-22, and IL-6. tam 44-47 interleukin 6 Homo sapiens 115-119 17395587-3 2007 In this study we investigate the effects of common asthma treatments fluticasone propionate and beta(2) agonists salmeterol and salbutamol on IL-6 production in BEAS-2B and primary bronchial epithelial cells. Salmeterol Xinafoate 113-123 interleukin 6 Homo sapiens 142-146 17395587-4 2007 Salmeterol and salbutamol enhanced rhinovirus- and IL-1beta-induced IL-6 production; however, fluticasone treatment caused a reduction of IL-6 protein and mRNA. Salmeterol Xinafoate 0-10 interleukin 6 Homo sapiens 68-72 17395587-6 2007 The induction of IL-6 by salmeterol was dependent upon the beta(2) receptor and could also be induced by cAMP or cAMP-elevating agents forskolin and rolipram. Salmeterol Xinafoate 25-35 interleukin 6 Homo sapiens 17-21 16397231-7 2006 Bortezomib triggered a dose-dependent inhibition of vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) secretion by the MMECs, and reverse transcriptase-PCR confirmed drug-related down-regulation of VEGF, IL-6, insulin-like growth factor-I, Angiopoietin 1 (Ang1), and Ang2 transcription. Bortezomib 0-10 interleukin 6 Homo sapiens 98-111 16858347-7 2006 Treatment of men with ischemic heart disease with rosuvastatin (10 mg for 3 months) led to achievement of target values of LDLCH in 77% of them, to significant lowering of concentrations of CRP and interleukin 6, and to improvement of endothelial function. Rosuvastatin Calcium 50-62 interleukin 6 Homo sapiens 198-211 17392575-6 2006 Only beta-hydroxy lauric acid significantly stimulated interleukin-6 production at 10 microg/mL compared to control (533.9 +/- 218.1 versus 438.3 +/- 219.6 pg/mL, P < .05). 3-hydroxydodecanoic acid 5-29 interleukin 6 Homo sapiens 55-68 17222322-6 2007 Serum beta-CTx correlated negatively with serum PIIINP and proinflammatory cytokines (IL-2, IL-6, IL-8, TNF-alpha), and positively with anti-inflammatory cytokines (IL-1, TGF-beta), whereas serum PIIINP correlated positively with these proinflammatory cytokines and negatively with the anti-inflammatory cytokines. beta-ctx 6-14 interleukin 6 Homo sapiens 92-96 27915130-7 2017 The inhibitory action of intact- and gamma-irradiated quercetin on the production of IL-6 and TNF-alpha was not observed in the down-regulation of Tollip. Quercetin 54-63 interleukin 6 Homo sapiens 85-89 17081715-4 2007 During 24-72 h of incubation with a low (2x10(4) HSF cells/mL) density of cells, significant cytotoxicity was observed for methanol and ethyl acetate extracts at concentrations greater than 125 microg/mL. Methanol 123-131 interleukin 6 Homo sapiens 49-52 16426496-0 2005 The inhibitory effect of quercetin on IL-6 production by LPS-stimulated neutrophils. Quercetin 25-34 interleukin 6 Homo sapiens 38-42 16426496-3 2005 In the present study, we investigated the effects of quercetin on IL-6 production by LPS-stimulated neutrophils in human. Quercetin 53-62 interleukin 6 Homo sapiens 66-70 28676732-0 2017 Proinflammatory Cytokines IL-6 and TNF-alpha Increased Telomerase Activity through NF-kappaB/STAT1/STAT3 Activation, and Withaferin A Inhibited the Signaling in Colorectal Cancer Cells. withaferin A 121-133 interleukin 6 Homo sapiens 26-30 16426496-7 2005 However, after pre-treatment of neutrophils with quercetin (40 microM) for 30 min, the inducible effects of LPS on the increase of IL-6 secretion, intracellular IL-6 level and IL-6 mRNA expression by neutrophils were abrogated. Quercetin 49-58 interleukin 6 Homo sapiens 131-135 16426496-7 2005 However, after pre-treatment of neutrophils with quercetin (40 microM) for 30 min, the inducible effects of LPS on the increase of IL-6 secretion, intracellular IL-6 level and IL-6 mRNA expression by neutrophils were abrogated. Quercetin 49-58 interleukin 6 Homo sapiens 161-165 16426496-7 2005 However, after pre-treatment of neutrophils with quercetin (40 microM) for 30 min, the inducible effects of LPS on the increase of IL-6 secretion, intracellular IL-6 level and IL-6 mRNA expression by neutrophils were abrogated. Quercetin 49-58 interleukin 6 Homo sapiens 161-165 16426496-9 2005 Thus, our data suggested that quercetin might exert its anti-inflammatory effect through negatively modulating pro-inflammatory factors, such as IL-6. Quercetin 30-39 interleukin 6 Homo sapiens 145-149 17202359-7 2007 Production of IL-6 (p < 0.0001) and TNF-alpha (p = 0.003) after stimulation by N-palmitoyl-S-[2,3-bis(palmitoyloxy)-(2R,S)-propyl]-Cys-[S]-Ser1-[S]-Lys(4) trihydrochloride was strongly associated with TLR1 surface expression. n-palmitoyl-s-[2,3-bis(palmitoyloxy)-(2r,s)-propyl]-cys-[s]-ser1-[s]-lys(4) trihydrochloride 82-174 interleukin 6 Homo sapiens 14-18 28676732-8 2017 Withaferin A, an anti-inflammatory steroidal lactone, inhibited the IL-6- and TNF-alpha-induced cancer cell invasion and decreased colonosphere formation. withaferin A 0-12 interleukin 6 Homo sapiens 68-87 16426496-10 2005 The inhibitory effects of quercetin on IL-6 production by neutrophils may provide a theoretical basis on future therapy of inflammation. Quercetin 26-35 interleukin 6 Homo sapiens 39-43 29430085-6 2017 This review discusses the available evidence regarding the potential antiatherosclerotic effects of methotrexate through the inhibition of TNF-alpha, IL-1, and IL-6 and provides suggestions for future experimental and human studies addressing this issue. Methotrexate 100-112 interleukin 6 Homo sapiens 160-164 16223437-1 2005 The objective was to investigate the relationship between homocysteine (HCY), peroxisome proliferator-activated receptors (PPAR)-gamma and the expression of interleukin 6 (IL-6) and microsomal prostaglandin E synthase (mPGES) by peripheral blood mononuclear cell (PBMC) culture in vitro, as well as to look at the intervention with HCY and PPAR-gamma activators (troglitazone and rosiglitazone). Troglitazone 363-375 interleukin 6 Homo sapiens 157-170 18240867-8 2007 In patients who stopped taking stavudine or zidovudine, the number of TNFalpha- and IL6-expressing cells was lower at month 6 than at month 0, and so was CD68 expression, a macrophage marker. Zidovudine 44-54 interleukin 6 Homo sapiens 84-87 29558759-5 2017 Thus, the main aim of this clinical trial study was to determine the effects of treatment with risperidone and quetiapine, as antipsychotic drugs, with and without vitamin B12 on the psychotic symptoms of AD patients and the expression of IL-6, IL-8, tumor growth factor (TGF)-beta, tumor necrosis factor (TNF)-alpha, and endothelin (ET)-1). Quetiapine Fumarate 111-121 interleukin 6 Homo sapiens 239-243 18260902-5 2007 IL-6 and CRP serum levels were also decreased after rosuvastatin therapy. Rosuvastatin Calcium 52-64 interleukin 6 Homo sapiens 0-4 16168297-9 2005 During the acute phase, GT+TT had higher ox-LDL and IL-6 (131.2 +/- 6.4 IU/l and 8.5 +/- 0.7 pg/ml) compared with GG (101.7 +/- 9.64 IU/l and 6.2 +/- 0.8 pg/ml, p < 0.05 for both), but no difference was found at one year. gt+tt 24-29 interleukin 6 Homo sapiens 52-56 28083615-0 2016 Functional Polymorphism in the Interleukin 6 (IL6) Gene with Respect to Depression Induced in the Course of Interferon-alpha and Ribavirin Treatment in Chronic Hepatitis Patients. Ribavirin 129-138 interleukin 6 Homo sapiens 46-49 15860671-9 2005 In addition, IFN treatment attenuated the interleukin 6 (IL-6)-dependent activation of signal transducer and activator of transcription 3 (Stat3), interfering with a known survival pathway in MM that has previously been linked with resistance to Fas-mediated apoptosis. ammonium ferrous sulfate 246-249 interleukin 6 Homo sapiens 57-61 17126656-8 2006 Levosimendan beneficially modulated neurohormonal and inflammatory status by decreasing B-type natriuretic peptide levels (p <0.05) and by altering the ratio of interleukin-6 to interleukin-10 in favor of the latter (p <0.05). Simendan 0-12 interleukin 6 Homo sapiens 164-177 28083615-2 2016 The aim of the study was to explore the association between IL6 gene C-174G polymorphism and depressive symptom severity in the longitudinal study design following the course of pegylated interferon/ribavirin treatment in CHC patients. Ribavirin 199-208 interleukin 6 Homo sapiens 60-63 16713737-6 2006 In the remaining 27 patients, levosimendan decreased serum IL-6 and sFAS, 24 h after the infusion (p<0.01 and p<0.05 vs baseline), an effect sustained for 7-30 d. Serum TNF-alpha and sTNF-R1 were decreased between 48 h (p<0.01 vs baseline for both) and 7 d (p<0.05 vs baseline for sTNF-R1) after infusion. Simendan 30-42 interleukin 6 Homo sapiens 59-63 15921958-4 2005 Levosimendan produced a significant reduction in BNP compared to baseline, at both 48 h (744.1+/-100 vs 1136.3+/-93.7 pg/ml, p=0.04) and 5 days (446+/-119.3 vs 1136.3+/-93.7 pg/ml, p=0.03), while IL-6 values decreased after 5 days (4.8+/-1.3 vs 8.6+/-1.5 pg/ml, p=0.01). Simendan 0-12 interleukin 6 Homo sapiens 196-200 27632703-4 2016 In the present study, we demonstrated that a water-soluble bis-malonic acid fullerene derivative (C60-dicyclopropane-1,1,1",1"-tetracarboxylic acid) markedly diminished the IL-33-induced expression of IL-6 in bone marrow-derived mast cells (BMMC). c60-dicyclopropane-1,1,1",1"-tetracarboxylic acid 98-147 interleukin 6 Homo sapiens 201-205 15717324-8 2005 The results also show that angiotensin II (AngII) is mainly secreted by CFs and induces IL-6 secretion in CMs cultured with CFs or with FCM. Californium 124-127 interleukin 6 Homo sapiens 88-92 17121906-8 2006 RESULTS: Among the National Cancer Institute Diversity set, a 2,000-member library of bioactive small molecules, we identified SD-1029 as a micromolar inhibitor of IL-6 or oncostatin-induced Stat3 nuclear translocation. SD 1029 127-134 interleukin 6 Homo sapiens 164-168 16046706-7 2005 Disrupting mitogen-activated protein kinase/Erk kinase (MEK) and protein kinase C (PKC) activity with U0126 and Bisindolylmaleimide (Bis), respectively, suppressed palmitate-induced IL-6 expression (P < 0.05), but had no effect on NF-kappaB reporter gene activity (P > 0.05). bisindolylmaleimide 112-131 interleukin 6 Homo sapiens 182-186 27183218-11 2016 Inhibition of CXCL4 reduced taurocholate-induced neutrophil recruitment, IL-6 secretion, edema formation, amylase release, and tissue damage in the pancreas. Taurocholic Acid 28-40 interleukin 6 Homo sapiens 73-77 16046706-7 2005 Disrupting mitogen-activated protein kinase/Erk kinase (MEK) and protein kinase C (PKC) activity with U0126 and Bisindolylmaleimide (Bis), respectively, suppressed palmitate-induced IL-6 expression (P < 0.05), but had no effect on NF-kappaB reporter gene activity (P > 0.05). bisindolylmaleimide 112-115 interleukin 6 Homo sapiens 182-186 15953089-6 2005 The levels of soluble IL-2R, IL-5 and IL-6 were significantly higher in the PAA patients than the controls. paa 76-79 interleukin 6 Homo sapiens 38-42 16955215-6 2006 Concomitantly, for the +647 MT1a polymorphism, old and very old female with Asp/Asp genotype (called C-carriers) display higher zinc release by MT (detected by Zinpyr-1 fluorescent probe in presence of NO donor), low MT levels and reduced IL-6 plasma concentrations, suggesting its involvement in longevity and in lower inflammatory status. Aspartic Acid 76-79 interleukin 6 Homo sapiens 239-243 27694691-0 2016 Interleukin-6 expression contributes to lapatinib resistance through maintenance of stemness property in HER2-positive breast cancer cells. Lapatinib 40-49 interleukin 6 Homo sapiens 0-13 16955215-6 2006 Concomitantly, for the +647 MT1a polymorphism, old and very old female with Asp/Asp genotype (called C-carriers) display higher zinc release by MT (detected by Zinpyr-1 fluorescent probe in presence of NO donor), low MT levels and reduced IL-6 plasma concentrations, suggesting its involvement in longevity and in lower inflammatory status. Aspartic Acid 80-83 interleukin 6 Homo sapiens 239-243 15974888-6 2005 Levosimendan-induced improvement in contractile reserve and clinical status of severe heart failure patients, seems to be related with the reduction of major pro-inflammatory cytokines (TNF-alpha, IL-6) and soluble apoptosis signaling molecules Fas/Fas Ligand. Simendan 0-12 interleukin 6 Homo sapiens 197-201 27694691-3 2016 In a previous study, we found that interleukin-6 (IL-6) production was increased in acquired lapatinib-resistant HER2-positive breast cancer cells. Lapatinib 93-102 interleukin 6 Homo sapiens 35-48 17022850-5 2006 RESULTS: Gliclazide MR treatment produced significant reductions in fasting plasma glucose (from 7.6 +/- 1.4 to 6.6 +/- 1.2 mmol/L, p < 0.01), HbA(1c) (from 7.6 +/- 1.1 to 6.9 +/- 0.8%, p < 0.01), and plasma IL-6 concentrations (from 2.5 +/- 1.8 to 1.8 +/- 1.2 pg/mL, p < 0.05). Gliclazide 9-19 interleukin 6 Homo sapiens 214-218 27694691-3 2016 In a previous study, we found that interleukin-6 (IL-6) production was increased in acquired lapatinib-resistant HER2-positive breast cancer cells. Lapatinib 93-102 interleukin 6 Homo sapiens 50-54 16093575-7 2005 Troglitazone improved insulin sensitivity (mean increase in whole body glucose uptake 23.1 +/- 10.5% (p = 0.047)) and normalised plasma concentrations of hsCRP, tPA and TNF-alpha, whereas it did not significantly change IL-6, leptin and PAI-1. Troglitazone 0-12 interleukin 6 Homo sapiens 220-224 27694691-4 2016 In the present study, we confirmed that lapatinib-resistant cells had elevated IL-6 expression and also maintained both stemness population and property. Lapatinib 40-49 interleukin 6 Homo sapiens 79-83 27694691-6 2016 Blocking IL-6 activity reduced spheroid formation, cell viability and subsequently overcame lapatinib resistance, whereas stimulation of IL-6 rendered parental cells more resistant to lapatinib-induced cytotoxicity. Lapatinib 92-101 interleukin 6 Homo sapiens 9-13 27694691-6 2016 Blocking IL-6 activity reduced spheroid formation, cell viability and subsequently overcame lapatinib resistance, whereas stimulation of IL-6 rendered parental cells more resistant to lapatinib-induced cytotoxicity. Lapatinib 184-193 interleukin 6 Homo sapiens 137-141 16986718-5 2006 Serum interleukin-6 level was also increased after the administration of bortezomib. Bortezomib 73-83 interleukin 6 Homo sapiens 6-19 27694691-7 2016 These results point to a novel mechanism underlying lapatinib resistance and provide a potential strategy to overcome resistance via IL-6 inhibition. Lapatinib 52-61 interleukin 6 Homo sapiens 133-137 15843470-3 2005 IL-6 production induced by IL-1, TNF-alpha, and IL-17 was specifically inhibited by the c-jun NH(2)-terminal kinase (JNK) inhibitor SP600125, but not by a selective inhibitor of p38 MAPK, and was moderately increased when the ERK1/2 pathway was inhibited. pyrazolanthrone 132-140 interleukin 6 Homo sapiens 0-4 27020921-9 2016 IL-6 and IL-10 levels significantly increased, while IFN-gamma level decreased in both groups during the surgery and 3 days after the surgery compared to those before the surgery; 2 weeks after the surgery, IL-6 and IL-10 levels in the MIE group recovered to the pre-operative levels (all P < 0.05). mie 236-239 interleukin 6 Homo sapiens 0-4 15843470-6 2005 Furthermore, IL-1-induced transcriptional activation of the IL-6 promotor was repressed by SP600125 or by co-transfection of a dominant-negative expression plasmid of c-jun even in the absence of a functional AP-1 binding site. pyrazolanthrone 91-99 interleukin 6 Homo sapiens 60-64 27131739-7 2016 Treating EpCAM+/CD133+ cancer stem cells with IL6 receptor blocking antibody or c-Met inhibitor SU11274 both reduced the increase in motility; however SU11274 had greater effect on relieving protection from sorafenib-induced apoptosis. Sorafenib 207-216 interleukin 6 Homo sapiens 46-49 15836625-0 2005 Up-regulation of interleukin-6 induced by prostaglandin E from invading macrophages following nerve injury: an in vivo and in vitro study. Prostaglandins E 42-57 interleukin 6 Homo sapiens 17-30 15618359-12 2005 IL-6, in turn, increased PGE(2) secretion, COX-2, and EP receptor subtype expression in bone cells. Prostaglandins E 25-28 interleukin 6 Homo sapiens 0-4 15618359-13 2005 Finally, IL-6 was the mediator of PGE(2)-induced suppression of OPG production by osteoblasts. Prostaglandins E 34-37 interleukin 6 Homo sapiens 9-13 16963274-4 2006 CGS21680 inhibited TLR4-mediated TNF-alpha release and potentiated TLR3- and TLR5-mediated IL-6 release. 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine 0-8 interleukin 6 Homo sapiens 91-95 26981789-9 2016 MTX was significantly induced IL-1beta and IL-6.17beta-estradiol, PPT and G-1 significantly decreased effects of MTX. Methotrexate 0-3 interleukin 6 Homo sapiens 43-47 16269423-3 2006 RESULTS: The most significant intracellular decrease in cytokines was observed by ICC in SM treated with the combination of Lef-M (1, 10, 30 micromol/l) and MTX (50 ng/ml) versus untreated SM (TNFalpha 29%, 37%, 49%, IL1beta 56%, 43%, 50%, and IL6 59%, 62%, 71%, respectively). Methotrexate 157-160 interleukin 6 Homo sapiens 244-247 16269423-4 2006 Furthermore, a significant decrease was confirmed concerning cytokine levels evaluated by ELISA in the medium of SM treated with the combination Lef-M+MTX (TNFalpha 40%, 41%, 44%; IL1beta 10%, 20%, 60%; IL6 37%, 41%, 49%, respectively). Methotrexate 151-154 interleukin 6 Homo sapiens 203-206 15804289-9 2005 Heat shock also increased lipoteichoic acid- or lipopolysaccharide-induced interleukin-6 production by monocytes. lipoteichoic acid 26-43 interleukin 6 Homo sapiens 75-88 27279714-12 2016 In addition, quercetin could reduce the inflammation factors production of TNF-alpha, Cox-2, and IL-6. Quercetin 13-22 interleukin 6 Homo sapiens 97-101 15781640-3 2005 DHEA-S and DHEA suppressed IL-6 production from a bone marrow stromal cell line, KM-102, as well as in bone marrow mononuclear cells from patients with myeloma. km-102 81-87 interleukin 6 Homo sapiens 27-31 16413037-1 2006 In this study, the effects of 15d-PGJ(2) were investigated in IL-6-activated endothelial cells (ECs). 15d-pgj 30-37 interleukin 6 Homo sapiens 62-66 27080462-8 2016 After quetiapine treatment, IL-2, IL-6 and IL-10 remained higher than the controls, but IL-10 was significantly decreased in follow-up comparison. Quetiapine Fumarate 6-16 interleukin 6 Homo sapiens 34-38 16413037-2 2006 15d-PGJ(2) was found to abrogate phosphorylation on tyr705 of STAT3 in IL-6-treated ECs, in a dose- and time-dependent manner, but did not inhibit serine phosphorylation of STAT3 and the upperstream JAK2 phosphorylation. 15d-pgj 0-7 interleukin 6 Homo sapiens 71-75 16413037-10 2006 The inhibition of ICAM-1 gene expression by 15d-PGJ(2) was abrogated by NAC and glutathione in IL-6-treated ECs. 15d-pgj 44-51 interleukin 6 Homo sapiens 95-99 16413037-11 2006 Taken together, these results suggest that 15d-PGJ(2) inhibits IL-6-stimulated phosphorylation on tyr705 of STAT3 dependent on its own electrophilic reactivity in ECs. 15d-pgj 43-50 interleukin 6 Homo sapiens 63-67 16173530-10 2005 Because RAU is probably a Thl-mediated disease with elevated levels of IL-2, IFN-gamma, TNF-alpha and IL-6 in either the patient"s sera or oral lesions and these increased levels of cytokines can be reduced by THL, we suggest that THL may be a potential immunoceutical agent for treatment of RAU. Orlistat 26-29 interleukin 6 Homo sapiens 102-106 15936434-2 2005 The predicted 227 aa IL-6 homologue contains the IL-6/G-CSF/MGF motif, has a predicted secondary structure of four alpha-helixes but only contains two of the four cysteines important in disulphide bond formation. disulphide 186-196 interleukin 6 Homo sapiens 21-25 26929256-1 2016 Icodextrin peritoneal dialysis (PD) solution has been shown to increase interleukin-6 (IL-6) levels in PD effluent as well as leukocyte and mesothelial cell count. Icodextrin 0-10 interleukin 6 Homo sapiens 72-85 15629668-2 2005 Therefore we determined whether a common guanine/cytosine polymorphism at position -174 of the promoter of the IL-6 gene (IL6) known to affect in vivo protein activity can serve as candidate gene for this condition. Guanine 41-48 interleukin 6 Homo sapiens 111-115 15629668-2 2005 Therefore we determined whether a common guanine/cytosine polymorphism at position -174 of the promoter of the IL-6 gene (IL6) known to affect in vivo protein activity can serve as candidate gene for this condition. Guanine 41-48 interleukin 6 Homo sapiens 122-125 15629668-2 2005 Therefore we determined whether a common guanine/cytosine polymorphism at position -174 of the promoter of the IL-6 gene (IL6) known to affect in vivo protein activity can serve as candidate gene for this condition. Cytosine 49-57 interleukin 6 Homo sapiens 111-115 15629668-2 2005 Therefore we determined whether a common guanine/cytosine polymorphism at position -174 of the promoter of the IL-6 gene (IL6) known to affect in vivo protein activity can serve as candidate gene for this condition. Cytosine 49-57 interleukin 6 Homo sapiens 122-125 26929256-1 2016 Icodextrin peritoneal dialysis (PD) solution has been shown to increase interleukin-6 (IL-6) levels in PD effluent as well as leukocyte and mesothelial cell count. Icodextrin 0-10 interleukin 6 Homo sapiens 87-91 15561952-10 2004 We show here that the common plasma FFA palmitate induces high levels of IL-6 in CAECs. Fatty Acids, Nonesterified 36-39 interleukin 6 Homo sapiens 73-77 16638192-1 2006 To explore the effect of arsenic trioxide (As2O3) on growth and secretion of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) of bone marrow stroma cells (BMSC) from the patients with multiple myeloma (MM). Arsenic Trioxide 25-41 interleukin 6 Homo sapiens 77-90 27186262-0 2016 Overexpression of variant PNPLA3 gene at I148M position causes malignant transformation of hepatocytes via IL-6-JAK2/STAT3 pathway in low dose free fatty acid exposure: a laboratory investigation in vitro and in vivo. Fatty Acids, Nonesterified 143-158 interleukin 6 Homo sapiens 107-111 16638192-1 2006 To explore the effect of arsenic trioxide (As2O3) on growth and secretion of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) of bone marrow stroma cells (BMSC) from the patients with multiple myeloma (MM). Arsenic Trioxide 43-48 interleukin 6 Homo sapiens 77-90 16638192-1 2006 To explore the effect of arsenic trioxide (As2O3) on growth and secretion of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) of bone marrow stroma cells (BMSC) from the patients with multiple myeloma (MM). Arsenic Trioxide 43-48 interleukin 6 Homo sapiens 92-96 16638192-10 2006 It is concluded that As2O3 has no inhibitory effect on cell growth of BMSC, but inhibit the production of IL-6 and VEGF by BMSC. Arsenic Trioxide 21-26 interleukin 6 Homo sapiens 106-110 15550066-5 2004 Effects of PD98059, SB202190 and SP600125 (inhibitors of ERK, p38 and JNK, respectively) on IL-1beta-induced secretion of IL-6 and IL-8, and on IL-1beta-induced expression of cyclo-oxygenase-2 (COX-2) in endometriotic cells were studied. pyrazolanthrone 33-41 interleukin 6 Homo sapiens 122-126 26768725-8 2016 The immunocytochemistry to detect IL-6 expression and immunofluorescence assay suggested that induced apoptosis occurs in experimentally induced in vitro arthritis model treated with NLCs-MTX. Methotrexate 188-191 interleukin 6 Homo sapiens 34-38 15550066-8 2004 Both SB202190 and SP600125 suppressed IL-1beta-induced secretion of IL-6 and IL-8, and PD98059 suppressed IL-1beta-induced secretion of IL-8. pyrazolanthrone 18-26 interleukin 6 Homo sapiens 68-72 15467434-2 2004 In multiple myeloma (MM), IL-6 prevents spontaneous, drug-induced, and Fas-induced apoptosis. ammonium ferrous sulfate 71-74 interleukin 6 Homo sapiens 26-30 26810262-0 2016 Structure-activity relationship study of a series of novel oxazolidinone derivatives as IL-6 signaling blockers. Oxazolidinones 59-72 interleukin 6 Homo sapiens 88-92 15316561-5 2004 Importantly, 15d-PGJ(2) selectively abrogated constitutive and IL-6-mediated JAK phosphorylation without affecting EGFR-activated levels. 15d-pgj 13-20 interleukin 6 Homo sapiens 63-67 16197469-7 2005 NF-kappaB inhibitor BAY 11-7082 and p38 MAPK inhibitor SB 203580 significantly decreased IL-6 release in a co-culture of BEAS-2B cells and eosinophils. 3-(4-methylphenylsulfonyl)-2-propenenitrile 20-31 interleukin 6 Homo sapiens 89-93 26810262-1 2016 A series of oxazolidinone and indole derivatives were synthesized and evaluated as IL-6 signaling blockers by measuring the effects of these compounds on IL-6-induced luciferase expression in human hepatocarcinoma HepG2 cells transfected with p-STAT3-Luc. Oxazolidinones 12-25 interleukin 6 Homo sapiens 83-87 16214025-7 2005 Plasma IL-6 levels, determined by ELISA, also increased following tasks, with maximum levels detected 2h post-stress. Deuterium 102-104 interleukin 6 Homo sapiens 7-11 15316561-8 2004 Our findings provide the first evidence for 15d-PGJ(2)-mediated downregulation of constitutive and IL-6-induced JAK signalling in cancer and support that JAK inhibition and suppression of EGFR-independent Stat3 activation by 15d-PGJ(2) represent a promising approach for induction of apoptosis in oral SCC cells. 15d-pgj 44-51 interleukin 6 Homo sapiens 99-103 15316561-8 2004 Our findings provide the first evidence for 15d-PGJ(2)-mediated downregulation of constitutive and IL-6-induced JAK signalling in cancer and support that JAK inhibition and suppression of EGFR-independent Stat3 activation by 15d-PGJ(2) represent a promising approach for induction of apoptosis in oral SCC cells. 15d-pgj 225-232 interleukin 6 Homo sapiens 99-103 26026604-12 2016 The proportionately smaller magnitude of response observed for MBDA score versus DAS28-CRP may be due to the influence of the increase in IL-6 concentrations on MBDA score. 3-benzoyl dopamine 63-67 interleukin 6 Homo sapiens 138-142 15342284-7 2004 IL-6 was decreased 17% by enalapril and 20% by losartan. Enalapril 26-35 interleukin 6 Homo sapiens 0-4 15342284-9 2004 In these high producers of IL-6, release of IL-6 was decreased 51% by enalapril (adjusted p = 0.001) and 32% by losartan (adjusted p = 0.068). Enalapril 70-79 interleukin 6 Homo sapiens 27-31 15342284-9 2004 In these high producers of IL-6, release of IL-6 was decreased 51% by enalapril (adjusted p = 0.001) and 32% by losartan (adjusted p = 0.068). Enalapril 70-79 interleukin 6 Homo sapiens 44-48 15342284-12 2004 Enalapril produced a highly significant decrease of 51% in the release of IL-6 in patients identified as high producers of IL-6 by the -174 G/C polymorphism, whereas losartan has a similar but less marked effect. Enalapril 0-9 interleukin 6 Homo sapiens 74-78 15342284-12 2004 Enalapril produced a highly significant decrease of 51% in the release of IL-6 in patients identified as high producers of IL-6 by the -174 G/C polymorphism, whereas losartan has a similar but less marked effect. Enalapril 0-9 interleukin 6 Homo sapiens 123-127 15315713-7 2004 Similarly, IL-6 and IL-6r were highly correlated with PaO2/FiO2 (r = -0.27, p < 0.05 and r = -0.55, p < 0.0001, respectively). pao2 54-58 interleukin 6 Homo sapiens 11-15 16054474-1 2005 In this randomized, placebo-controlled study, it was found that a 24-hour levosimendan infusion improves echocardiographic markers of abnormal left ventricular diastolic function (transmitral flow patterns and mitral annulus velocities, as assessed by transthoracic pulse-wave Doppler and tissue Doppler imaging, respectively) and reduces substances of excessive neurohormonal activation (plasma B-type natriuretic peptide and interleukin-6) in patients with advanced heart failure. Simendan 74-86 interleukin 6 Homo sapiens 427-440 26485167-4 2016 LH gels incorporating cGAMP (LH/cGAMP gels) elicited excellent induction of the cytokines interferon-beta (IFN-beta) and interleukin-6 (IL-6). cyclic guanosine monophosphate-adenosine monophosphate 22-27 interleukin 6 Homo sapiens 121-134 15912140-6 2005 Release of IL-6, IL-8 and TNF-alpha was inhibited by 82-93% at 100 microM quercetin and kaempferol, and 31-70% by myricetin and morin. Quercetin 74-83 interleukin 6 Homo sapiens 11-15 26485167-4 2016 LH gels incorporating cGAMP (LH/cGAMP gels) elicited excellent induction of the cytokines interferon-beta (IFN-beta) and interleukin-6 (IL-6). cyclic guanosine monophosphate-adenosine monophosphate 22-27 interleukin 6 Homo sapiens 136-140 26485167-4 2016 LH gels incorporating cGAMP (LH/cGAMP gels) elicited excellent induction of the cytokines interferon-beta (IFN-beta) and interleukin-6 (IL-6). cyclic guanosine monophosphate-adenosine monophosphate 32-37 interleukin 6 Homo sapiens 121-134 26485167-4 2016 LH gels incorporating cGAMP (LH/cGAMP gels) elicited excellent induction of the cytokines interferon-beta (IFN-beta) and interleukin-6 (IL-6). cyclic guanosine monophosphate-adenosine monophosphate 32-37 interleukin 6 Homo sapiens 136-140 16076382-9 2005 There was a significant positive correlation between blood level of IL-6 and IAP, suggesting that PMMA-CHDF improved vascular permeability through elimination of cytokines, and that it thereby decreased interstitial edema to lower IAP. pmma-chdf 98-107 interleukin 6 Homo sapiens 68-80 15075299-3 2004 In the present study, we hypothesized that suppressing lipolysis, and subsequent free fatty acid (FFA) availability, would result in a compensatory elevation in IL-6 at rest and during exercise. Fatty Acids, Nonesterified 81-96 interleukin 6 Homo sapiens 161-165 15075299-3 2004 In the present study, we hypothesized that suppressing lipolysis, and subsequent free fatty acid (FFA) availability, would result in a compensatory elevation in IL-6 at rest and during exercise. Fatty Acids, Nonesterified 98-101 interleukin 6 Homo sapiens 161-165 27738630-0 2016 The -174G/C Interleukin-6 Gene Promoter Polymorphism as a Genetic Marker of Differences in Therapeutic Response to Methotrexate and Leflunomide in Rheumatoid Arthritis. Methotrexate 115-127 interleukin 6 Homo sapiens 12-25 15135713-1 2004 This randomized, placebo-controlled trial showed that levosimendan administration causes a significant reduction of circulating proinflammatory cytokine interleukin-6 and soluble apoptosis mediators, such as soluble Fas and Fas ligand in patients with decompensated heart failure. Simendan 54-66 interleukin 6 Homo sapiens 153-166 16000871-4 2005 We examined the possibility that IL-6 signaling via the Jak-Stat pathway is modulated by 15d-PGJ(2) in lymphocytes and also examined whether the inhibition of IL-6 signaling is dependent of PPARgamma. 15d-pgj 89-96 interleukin 6 Homo sapiens 33-37 16000871-5 2005 15d-PGJ(2) blocked IL-6 induced Stat1 and Stat3 activation in primary human lymphocytes, Jurkat cells and immortalized rheumatoid arthritis B cells. 15d-pgj 0-7 interleukin 6 Homo sapiens 19-23 16000871-6 2005 Inhibition of IL-6 signaling was induced rapidly within 15 min after treatment of 15d-PGJ(2). 15d-pgj 82-89 interleukin 6 Homo sapiens 14-18 15219461-7 2004 Taken together, our results show that in response to PGE(2), BM-DC produce IL-10, which in turn down-regulates their own production of IL-6-, TNF-alpha-, and COX-2-derived prostanoids, and plays crucial roles in determining the BM-DC pro-inflammatory phenotype. Prostaglandins E 53-56 interleukin 6 Homo sapiens 135-139 27738630-2 2016 To evaluate the association of -174G/C IL-6 polymorphism with failure in therapeutic response to methotrexate (MTX) or leflunomide (LEF). Methotrexate 97-109 interleukin 6 Homo sapiens 39-43 16000871-7 2005 Other PPARgamma-agonists, such as troglitazone and ciglitazone, did not inhibit IL-6 signaling, indicating that 15d-PGJ(2) affect the IL-6-induced Jak-Stat signaling pathway via PPARgamma-independent mechanism. 15d-pgj 112-119 interleukin 6 Homo sapiens 134-138 27738630-2 2016 To evaluate the association of -174G/C IL-6 polymorphism with failure in therapeutic response to methotrexate (MTX) or leflunomide (LEF). Methotrexate 111-114 interleukin 6 Homo sapiens 39-43 15051824-6 2004 Quercetin reduced linoleic acid-mediated binding activity of NF-kappaB and AP-1 and mRNA levels of inflammatory genes such as interleukin-6 (IL-6) and vascular cell adhesion molecule-1 (VCAM-1). Quercetin 0-9 interleukin 6 Homo sapiens 126-139 27579328-9 2016 Plasma IL-8 and IL-6 levels were significantly higher in patients with PaO2/FiO2 <= 200 mmHg and nonsurvivors than in those with PaO2/FiO2 > 200 mmHg and survivors. pao2 71-75 interleukin 6 Homo sapiens 16-20 15051824-6 2004 Quercetin reduced linoleic acid-mediated binding activity of NF-kappaB and AP-1 and mRNA levels of inflammatory genes such as interleukin-6 (IL-6) and vascular cell adhesion molecule-1 (VCAM-1). Quercetin 0-9 interleukin 6 Homo sapiens 141-145 14975222-0 2004 Effects of morphine and fentanyl on tumor necrosis factor-alpha and interleukin-6 concentrations in human whole blood in vitro. Fentanyl 24-32 interleukin 6 Homo sapiens 68-81 16097634-4 2005 Anti-IL-6-receptor antibodies were conjugated with a bifunctional chelating agent, hydrazinonicotinamide (HYNIC), and radiolabeled with technetium-99m (99mTc) using the ligand exchange reaction of 99mTc-tricine complex. Technetium-99 136-149 interleukin 6 Homo sapiens 5-9 27579328-9 2016 Plasma IL-8 and IL-6 levels were significantly higher in patients with PaO2/FiO2 <= 200 mmHg and nonsurvivors than in those with PaO2/FiO2 > 200 mmHg and survivors. pao2 132-136 interleukin 6 Homo sapiens 16-20 27378823-11 2016 The ascent associated decrease in PaO2 correlated with the increase in IL-6 (r = 0.46, p < 0.001), but not suPAR (r = 0.27, p = 0.08); the increase in IL-6 was not correlated with suPAR (r = 0.16, p = 0.24). pao2 34-38 interleukin 6 Homo sapiens 71-75 15879108-3 2005 Interestingly, DOTAP-mediated enhanced endosomal translocation of otherwise nonstimulatory vertebrate DNA or of certain noncanonical CpG motifs triggers robust dendritic cell activation in terms of both up-regulation of CD40/CD69 and cytokine production, such as type I IFN and IL-6. 1,2-dioleoyloxy-3-(trimethylammonium)propane 15-20 interleukin 6 Homo sapiens 263-282 15078004-0 2004 Effect of multiple doses of clarithromycin and amoxicillin on IL-6, IFNgamma and IL-10 plasma levels in patients with community acquired pneumonia. Amoxicillin 47-58 interleukin 6 Homo sapiens 62-66 15078004-8 2004 In patients treated with amoxicillin a significant decrease in IL-6 plasma levels was observed at the 7th day of therapy, probably in relation to the resolution of inflammatory symptoms. Amoxicillin 25-36 interleukin 6 Homo sapiens 63-67 27378823-11 2016 The ascent associated decrease in PaO2 correlated with the increase in IL-6 (r = 0.46, p < 0.001), but not suPAR (r = 0.27, p = 0.08); the increase in IL-6 was not correlated with suPAR (r = 0.16, p = 0.24). pao2 34-38 interleukin 6 Homo sapiens 154-158 15806132-1 2005 Interleukin 6 (IL-6) is a major growth factor for myeloma cells and retinoids have been shown to inhibit expression of the interleukin 6 receptor (IL-6R). Retinoids 68-77 interleukin 6 Homo sapiens 0-13 15806132-1 2005 Interleukin 6 (IL-6) is a major growth factor for myeloma cells and retinoids have been shown to inhibit expression of the interleukin 6 receptor (IL-6R). Retinoids 68-77 interleukin 6 Homo sapiens 15-19 27378823-11 2016 The ascent associated decrease in PaO2 correlated with the increase in IL-6 (r = 0.46, p < 0.001), but not suPAR (r = 0.27, p = 0.08); the increase in IL-6 was not correlated with suPAR (r = 0.16, p = 0.24). supar 183-188 interleukin 6 Homo sapiens 154-158 14707068-2 2004 In this study, we found that both naive and memory B cells lack TLR4 (receptor for LPS) but express TLR9 (receptor for CpG motifs) and produce IL-6, TNF-alpha, and IL-10 upon stimulation with CpG oligonucleotides (ODN), synthetic mimics of microbial DNA. CPG-oligonucleotide 192-212 interleukin 6 Homo sapiens 143-147 27378823-15 2016 The correlation between IL-6 and PaO2 suggests a direct effect of hypoxia, which is not the case for suPAR. pao2 33-37 interleukin 6 Homo sapiens 24-28 27578923-8 2016 Cross-linking of GD1b derived gangliosides also resulted in the release of the newly synthesized mediators, interleukin-4, interleukin-6, and TNF-alpha. Gangliosides 30-42 interleukin 6 Homo sapiens 123-136 14557255-7 2004 Chemical shift mapping data with 15N-labeled IL-6R-D3 and unlabeled IL-6 coupled with recent structural data clearly reveal the epitope within the IL-6R-D3 responsible for mediating the high affinity interaction with its cognate cytokine. 15n 33-36 interleukin 6 Homo sapiens 45-49 15894327-5 2005 Following incubation with CpG oligonucleotide, Namalwa cells secreted increased amounts of TNF, IL-6, and IL-10 and expressed the costimulator molecules CD40, CD80, and CD86. CPG-oligonucleotide 26-45 interleukin 6 Homo sapiens 96-100 26592517-9 2015 Furthermore, treatment with Fe(2+) significantly increased the gene expression of IL-1beta, IL-6 and TNF-alpha, and induced the nuclear translocation of NF-kappaB. ammonium ferrous sulfate 28-34 interleukin 6 Homo sapiens 92-96 15771921-0 2005 Levosimendan reduces plasma B-type natriuretic peptide and interleukin 6, and improves central hemodynamics in severe heart failure patients. Simendan 0-12 interleukin 6 Homo sapiens 59-72 15771921-3 2005 This study investigates whether levosimendan-induced hemodynamic improvement of CHF patients is related to the respective changes of NT-proBNP and IL-6 levels. Simendan 32-44 interleukin 6 Homo sapiens 147-151 15771921-6 2005 RESULTS: NT-proBNP and IL-6 levels were significantly reduced in severe CHF patients within 72 h after the initiation of levosimendan treatment (p<0.01 and p<0.05, respectively). Simendan 121-133 interleukin 6 Homo sapiens 23-27 15771921-9 2005 CONCLUSIONS: Our results indicate that changes of NT-pro BNP and IL-6 levels may be useful biochemical markers related with the levosimendan-induced improvement in central hemodynamics and the clinical status of decompensated advanced CHF patients. Simendan 128-140 interleukin 6 Homo sapiens 65-69 16146038-3 2004 We detected statistically significant higher serum level of interleukin-6 (IL-6) in patients with active disease and tendency to the lowering of FAS level, although not statistically significant. ammonium ferrous sulfate 145-148 interleukin 6 Homo sapiens 60-73 16146038-3 2004 We detected statistically significant higher serum level of interleukin-6 (IL-6) in patients with active disease and tendency to the lowering of FAS level, although not statistically significant. ammonium ferrous sulfate 145-148 interleukin 6 Homo sapiens 75-79 15773377-3 2004 The authors suggest using determination of serum antibodies to myeloprotein G and IL-1, IL-6 to specify severity of chronic manganese intoxication. Manganese 124-133 interleukin 6 Homo sapiens 88-92 26507164-8 2015 We found that icariin inhibited TNF-alpha/IFN-gamma-induced IL-6, IL-8, IL-1beta, and MCP-1 production in a dose-dependent manner; meanwhile, the icariin treatment inhibited the gene expression of IL-8, IL-1beta, ICAM-1 and TACR1 in HaCaT cells in a time- and dose-dependent manner. icariin 146-153 interleukin 6 Homo sapiens 60-64 15564333-7 2005 Treatment of adipose tissue and skeletal muscle with sulfasalazine and BAY 11-7082 significantly inhibited the release of IL-6, IL-8, and TNF-alpha; NF-kappa B p65 DNA-binding activity; and IKK-beta protein expression (P < 0.05, by Newman-Keuls test). 3-(4-methylphenylsulfonyl)-2-propenenitrile 71-82 interleukin 6 Homo sapiens 122-126 26643924-4 2015 ZIP2 Leu- (Arg43Arg) carriers showed enhanced IL-6, TNF-alpha, and RANTES plasma levels associated with decreased free cytosolic zinc in PBMCs and an upregulation of zinc transporters ZIP2, ZIP8, and Znt1. Leucine 5-8 interleukin 6 Homo sapiens 46-50 15735578-6 2005 Since a decrease in elevated markers of subclinical inflammation--nowadays regarded as the main culprit of cardiovascular complications and atherosclerosis--such as Interleukin-6 and C-reactive protein has been reported during CPAP therapy, and since an improvement in left ventricular function and a decrease in blood pressure were also reported under CPAP treatment, there are several good reasons to assume an improvement in metabolical function in OSAS patients due to CPAP treatment. cpap 227-231 interleukin 6 Homo sapiens 165-178 15383370-8 2005 Both IL-6 and AICAR markedly increased (P < 0.05) oxidation of [(14)C]palmitate compared with Control. [(14)c]palmitate 66-82 interleukin 6 Homo sapiens 5-9 12959977-0 2003 Soluble mannose 6-phosphate/insulin-like growth factor II (IGF-II) receptor inhibits interleukin-6-type cytokine-dependent proliferation by neutralization of IGF-II. mannose-6-phosphate 8-27 interleukin 6 Homo sapiens 85-98 14647474-4 2003 Neither exogenous IL-6 nor insulin-like growth factor-1 (IGF-1) overcome SP600125-induced growth inhibition, and IL-6 enhances SP600125-induced G2/M phase in MM.1S cells. pyrazolanthrone 127-135 interleukin 6 Homo sapiens 113-117 14627979-0 2003 Proteasome inhibitor PS-341 abrogates IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in multiple myeloma. Bortezomib 21-27 interleukin 6 Homo sapiens 38-42 14627979-2 2003 We have previously shown that PS-341 inhibits IL-6 triggered phosphorylation of extracellular signal-regulated kinases (ERK) 1/2 (also known as p42/44 mitogen-activated protein kinases) in MM cells. Bortezomib 30-36 interleukin 6 Homo sapiens 46-50 16164036-7 2005 The PKC inhibitor Dequalinium chloride (DECA) remarkably reduced the production of IL-6, NF-kappaB and the activity of PKC induced by the piliated S. typhi. Dequalinium 18-38 interleukin 6 Homo sapiens 83-87 14627979-3 2003 In this study, we further examined whether clinically achievable concentrations of PS-341 could inhibit IL-6 triggered signaling cascades in MM. Bortezomib 83-89 interleukin 6 Homo sapiens 104-108 26222701-13 2015 In the BM-CTP group, a significant increase of IL-6 but also of CRP and D-dimer was observed. bm-ctp 7-13 interleukin 6 Homo sapiens 47-51 14627979-8 2003 Z-VAD-FMK also abrogates the inhibitory effect of PS-341 on IL-6-triggered signaling cascades. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 0-9 interleukin 6 Homo sapiens 60-64 14627979-8 2003 Z-VAD-FMK also abrogates the inhibitory effect of PS-341 on IL-6-triggered signaling cascades. Bortezomib 50-56 interleukin 6 Homo sapiens 60-64 14627979-9 2003 Importantly, we demonstrate that phosphorylation of ERK, STAT3, and Akt in MM.1S cells induced by either exogenous IL-6 or by binding of MM cells to BM stromal cells is abrogated by PS-341. Bortezomib 182-188 interleukin 6 Homo sapiens 115-119 16218490-6 2005 Finally, TZDs induce synoviocyte apoptosis and reduce secretion of TNFalpha, IL-6 and IL-8 in synoviocyte from rheumatoid arthritis patients. Thiazolidinediones 9-13 interleukin 6 Homo sapiens 77-81 26535093-11 2015 EOLP (5%) cases with IL-6 levels above 5pg/ml were resistant in MTX group. Methotrexate 64-67 interleukin 6 Homo sapiens 21-25 15849476-7 2005 Treatment with intraperitoneal tinzaparin was accompanied with a median 25.8% reduction of the plasma C-reactive protein concentration (p = 0.032), a 7.3% reduction of the plasma fibrinogen concentration (p = 0.042) and a 54.5% reduction of the dialysate interleukin 6 appearance rate (p = 0.007) compared with placebo. Tinzaparin 31-41 interleukin 6 Homo sapiens 255-268 14642127-6 2003 RESULTS: After 96 hours exposure to arsenic trioxide, 10 - 6 mol/L in vitro or 10 mg/d in vivo, APL cells showed a significant increase of IL-1(beta) (P < 0.05) and G-CSF (P < 0.05) production, and a significant decrease of IL-6 (P < 0.05) and IL-8 (P < 0.05). Arsenic Trioxide 36-52 interleukin 6 Homo sapiens 230-234 12794182-5 2003 Furthermore, IL-6 has been demonstrated to have a lipolytic effect, thus possibly playing a role in mobilisation of energy as free fatty acids (FFA) in response to exercise. Fatty Acids, Nonesterified 126-142 interleukin 6 Homo sapiens 13-17 12891120-7 2003 RESULTS: PGE(2) or 11-deoxy-PGE(1) (EP 2/3/4 agonist) reversed partially the indomethacin suppression of IL-6 secretion from explant cultures, whereas butaprost (EP2 receptor agonist) and sulprostone (EP 1/3 receptor agonist) had no effect. Prostaglandins E 9-12 interleukin 6 Homo sapiens 105-109 27551463-9 2015 SAG overexpression stimulated protumorigenic cytokines, IL-1beta, IL-6 and TNF, but not antitumorigenic IL-12p40 and anti-inflammatory IL-10. sagopilone 0-3 interleukin 6 Homo sapiens 66-70 12732938-8 2003 Total intracellular PL contents were also unchanged; however, IL-6 led to significant changes in PL composition including an increase in phosphatidylethanolamine (PE) and sphingomyelin (SM) and a decrease in phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) ( p<0.05). Lysophosphatidylcholines 237-260 interleukin 6 Homo sapiens 62-66 12732938-8 2003 Total intracellular PL contents were also unchanged; however, IL-6 led to significant changes in PL composition including an increase in phosphatidylethanolamine (PE) and sphingomyelin (SM) and a decrease in phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) ( p<0.05). Lysophosphatidylcholines 262-265 interleukin 6 Homo sapiens 62-66 15474071-2 2004 DESIGN: The effects of IL-1alpha, IL-1 receptor antagonist (IL-1RA), C2-ceramide, and C6-ceramide on the production of IL-6, IL-8, and M-CSF by ESC. N-caproylsphingosine 86-97 interleukin 6 Homo sapiens 119-123 25641413-4 2015 Expression of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha in human umbilical vein endothelial cells (HUVECs) after LAS compound treatment was examined by enzyme-linked sorbent assay. alkylbenzyl sulfonic acid 128-131 interleukin 6 Homo sapiens 14-32 15480843-3 2004 We investigated the influence of the antiparkinsonian compound budipine on the release of TNF-alpha and Il-6 in peripheral blood mononuclear cells (PBMC) and on the degree of cisplatin induced apoptotic cell death in SH-SY 5Y human neuroblastoma cells. budipine 63-71 interleukin 6 Homo sapiens 104-108 15480843-4 2004 10(-7), 10(-8), 10(-9) mol/l of budipine significantly reduced release of TNF-alpha and Il-6 in PBMC and decreased apoptotic cell death after 50 hours and 74 hours in the SH-SY 5Y cells. budipine 32-40 interleukin 6 Homo sapiens 88-92 12782111-10 2003 This IL-6 release could be reduced by pretreatment with antagonists to the VR1 receptor (i.e. capsazepine) or to acid-sensitive ionc channels (i.e. amiloride). capsazepine 94-105 interleukin 6 Homo sapiens 5-9 12748876-4 2003 In addition, granulosa cells obtained from the follicular fluid were cultured and treated with forskolin and 12- o-tetradecanoylphorbol 13-acetate for 24-48 h. The concentration of IL-6 was significantly higher in the follicular fluid than in the serum (P<0.01). Colforsin 95-104 interleukin 6 Homo sapiens 181-185 12748876-7 2003 The production of IL-6 was markedly increased over the basal level after 24 h of treatment with forskolin (P<0.001) and 48 h of treatment (P<0.01) with cultured granulosa cells. Colforsin 96-105 interleukin 6 Homo sapiens 18-22 15322215-3 2004 15d-PGJ(2) potently inhibited the expression of microglial cytokines (IL-1, TNF-alpha, and IL-6). 15d-pgj 0-7 interleukin 6 Homo sapiens 91-95 26268945-5 2015 METHODS: We hypothesized that IL-6 paracrine signaling between DCIS cells and CAFs mediates DCIS proliferation and migration. cafs 78-82 interleukin 6 Homo sapiens 30-34 15526907-6 2004 Importantly, PPARgamma agonists troglitazone, rosiglitazone, and 15-deoxy-delta(12, 14)-prosglandin J2 significantly decreased the up expression of TNF-alpha and IL-6 in HMCL supernatants stimulated by IL-1beta. Troglitazone 32-44 interleukin 6 Homo sapiens 162-166 26268945-10 2015 Moreover, selective knockdown of IL-6 in CAFs, but not in DCIS cells, abrogated the migratory phenotype. cafs 41-45 interleukin 6 Homo sapiens 33-37 15526907-7 2004 Furthermore, troglitazone downregulated TNF-alpha and IL-6 mRNA expression from IL-1beta challenge HMCLs. Troglitazone 13-25 interleukin 6 Homo sapiens 54-58 12644313-7 2003 In mast cells derived from CD4+/CD133+ cells, IL-10 inhibits IL-6 and TNFalpha, and prostaglandin E(1) and E(2) induced by IL-6. Prostaglandins E 84-99 interleukin 6 Homo sapiens 123-127 26138903-8 2015 Honokiol showed an anti-inflammatory effect in PA-inducted HUVECs by significantly inhibiting the generation of interleukin-6 (IL-6), IL-8 and monocyte chemoattractant protein-1. honokiol 0-8 interleukin 6 Homo sapiens 112-125 12653859-7 2003 RESULTS: We found that about 99% of the normal control subjects and the patients with EM, TU, or OSF had a serum IL-6 level within the normal limit of 5.0 pg/ml. Thiouracil 90-92 interleukin 6 Homo sapiens 113-117 15266023-7 2004 8-Bromo-cADPr, a cADPr antagonist, significantly augmented TNFalpha-induced interleukin-6 secretion, whereas regulated on activation normal T cell expressed and secreted secretion was suppressed. 8-bromo-cyclic-ADP-ribose 0-13 interleukin 6 Homo sapiens 76-89 26138903-8 2015 Honokiol showed an anti-inflammatory effect in PA-inducted HUVECs by significantly inhibiting the generation of interleukin-6 (IL-6), IL-8 and monocyte chemoattractant protein-1. honokiol 0-8 interleukin 6 Homo sapiens 127-131 14872092-7 2004 Matured MoDCs induced by PGE(2) or EP2 and/or EP4 receptor agonists showed a decrease in lipopolysaccharide (LPS)-stimulated IL-12p70, IL-6, and IL-10 production. Prostaglandins E 25-28 interleukin 6 Homo sapiens 135-139 15219461-3 2004 IL-6, but not TNF-alpha, release is enhanced by PGE(2) in the presence of anti-IL-10, suggesting that endogenous IL-10 masks PGE(2)-induced IL-6. Prostaglandins E 48-51 interleukin 6 Homo sapiens 0-4 15219461-3 2004 IL-6, but not TNF-alpha, release is enhanced by PGE(2) in the presence of anti-IL-10, suggesting that endogenous IL-10 masks PGE(2)-induced IL-6. Prostaglandins E 125-128 interleukin 6 Homo sapiens 0-4 12623747-0 2003 Relation between immunosuppressive PGE(2) and IL-10 to pro-inflammatory IL-6 in seminal plasma of infertile and fertile men. Prostaglandins E 35-38 interleukin 6 Homo sapiens 72-76 12623747-3 2003 The present study was conducted to investigate the relation between immunosuppressive PGE(2) and IL-10 to pro-inflammatory IL-6 in seminal plasma of infertile and fertile men. Prostaglandins E 86-89 interleukin 6 Homo sapiens 123-127 15219461-3 2004 IL-6, but not TNF-alpha, release is enhanced by PGE(2) in the presence of anti-IL-10, suggesting that endogenous IL-10 masks PGE(2)-induced IL-6. Prostaglandins E 125-128 interleukin 6 Homo sapiens 140-144 25676331-4 2015 Results showed that MC13 markedly inhibited LPS-induced production of various inflammatory mediators, including nitrite oxide (Griess method), TNF-alpha and IL-6 (ELISA assay) in a concentration-dependent manner. mc13 20-24 interleukin 6 Homo sapiens 157-161 15219461-4 2004 Furthermore, both exogenous IL-10 and PGE(2) inhibit LPS-induced IL-6 and TNF-alpha, whereas selective inhibition of cyclooxygenase-2 (COX-2) or addition of anti-IL-10 causes the reverse effects. Prostaglandins E 38-41 interleukin 6 Homo sapiens 65-69 15051033-4 2004 RESULTS: Secretion (mean +/- standard error) of IL-6 was, for control conditions, 1.92 +/- 0.28 fmol/mg wet weight per 3 hours; for PGE(2), 3.57 +/- 0.29 fmol/mg wet weight per 3 hours, P <.01; and for carbacyclin, 3.11 +/- 0.44 fmol/mg wet weight per 3 hours, P <.01. Prostaglandins E 132-135 interleukin 6 Homo sapiens 48-52 12579318-7 2003 Treatment with anti-IL-6 antibody partially inhibited the proliferation of TAB1 cells cultured with BMCM. bmcm 100-104 interleukin 6 Homo sapiens 20-24 14722642-8 2004 C-reactive protein increased over time, but compared to the other groups it was significantly lower in patients receiving metamizol after 4 h. Cytokine concentrations were not different among the three groups or over time, although interleukin 6 tended to decrease over time in the metamizol group. Dipyrone 282-291 interleukin 6 Homo sapiens 232-245 25843360-11 2015 Similarly, activation of the transcription factor NF-kB promoter and release of interleukin-6 and -8 were increased following VOSO4 exposure and these effects were diminished by pre-treatment with FAC. vanadyl sulfate 126-131 interleukin 6 Homo sapiens 80-100 15016959-7 2004 At the latter concentration, the active form of 72 kDa gelatinase was induced at 48 h. Interleukin-6 and tumor necrosis factor-alpha levels increased at 1-3 h post endotoxin treatment and peaked at 6 h in cells on plastic and EHS-drip. ehs 226-229 interleukin 6 Homo sapiens 87-132 12620656-6 2003 Most MBP peptide-specific TCLs secreted considerable amounts of IFN-gamma and low amounts of IL-4 and IL-6, whereas anti rhMOG(Igd) peptide-specific TCLs secreted preferentially IL-4 and IL-6. tcls 26-30 interleukin 6 Homo sapiens 102-106 12651911-8 2003 Substantial qualitative and quantitative differences in PSA expression and AR occupancy of the PSA enhancer were observed when DHT-induced and ligand-independent activations of the AR were compared; forskolin stimulated PSA mRNA and protein expression, whereas IL-6 inhibited both DHT- and forskolin-stimulated expression. Colforsin 199-208 interleukin 6 Homo sapiens 261-265 26028838-0 2015 A prospective study to assess the levels of interleukin-6 following administration of diclofenac, ketorolac and tramadol after surgical removal of lower third molars. Ketorolac 98-107 interleukin 6 Homo sapiens 44-57 15019531-7 2004 In addition, Fcgamma receptor mediated immune complex trafficking, activation of MAP kinases (ERK and p38), and downstream inflammatory mediator release (MMP-1 and IL-6) were blocked by fluvastatin. Fluvastatin 186-197 interleukin 6 Homo sapiens 164-168 26028838-7 2015 AIM: To evaluate the changes in serum IL-6 levels following surgical removal of third molars under local anaesthesia after administration of two NSAIDs diclofenac and ketorolac and opioid tramadol post operatively. Ketorolac 167-176 interleukin 6 Homo sapiens 38-42 14638469-2 2003 Moxifloxacin inhibited the production of tumor necrosis factor alpha (TNF-alpha) and/or interleukin-6 (IL-6) by PBMCs stimulated with lipopolysaccharide (LPS), lipoteichoic acid (LTA), and heat-killed bacteria in a concentration-dependent manner without cytotoxic effects. lipoteichoic acid 160-177 interleukin 6 Homo sapiens 103-107 12592380-9 2003 Sant 7, however, inhibited PGE(2)-stimulated aromatase activity by 70% suggesting that PGE(2) acts, in part, by stimulating IL-6 production. Prostaglandins E 27-30 interleukin 6 Homo sapiens 124-128 26028838-11 2015 RESULTS: The results of our study showed that all three drugs i.e. diclofenac, ketorolac and tramadol have properties which can downregulate the production of IL-6 in response to surgical trauma. Ketorolac 79-88 interleukin 6 Homo sapiens 159-163 12592380-9 2003 Sant 7, however, inhibited PGE(2)-stimulated aromatase activity by 70% suggesting that PGE(2) acts, in part, by stimulating IL-6 production. Prostaglandins E 87-90 interleukin 6 Homo sapiens 124-128 14627919-0 2003 C-jun N-terminal kinase (JNK) inhibitor, SP600125, blocks interleukin (IL)-6-induced vascular endothelial growth factor (VEGF) production: cyclosporine A partially mimics this inhibitory effect. pyrazolanthrone 41-49 interleukin 6 Homo sapiens 58-76 14627919-6 2003 SP600125 significantly suppressed interleukin (IL)-6-induced production of VEGF in cultured fibroblasts. pyrazolanthrone 0-8 interleukin 6 Homo sapiens 34-52 26028838-13 2015 Even though the drug ketorolac suppresses the IL-6 levels similar to diclofenac initially but after 7 days tramadol and ketorolac showed similarities in suppression of IL-6 expression which is less compared to diclofenac group. Ketorolac 21-30 interleukin 6 Homo sapiens 46-50 26028838-13 2015 Even though the drug ketorolac suppresses the IL-6 levels similar to diclofenac initially but after 7 days tramadol and ketorolac showed similarities in suppression of IL-6 expression which is less compared to diclofenac group. Ketorolac 21-30 interleukin 6 Homo sapiens 168-172 26028838-13 2015 Even though the drug ketorolac suppresses the IL-6 levels similar to diclofenac initially but after 7 days tramadol and ketorolac showed similarities in suppression of IL-6 expression which is less compared to diclofenac group. Ketorolac 120-129 interleukin 6 Homo sapiens 168-172 12578976-8 2003 Furthermore, although both PGE(2) and PGE(3) induce IL-6 synthesis in RAW 264.7 macrophages, PGE(3) is substantially less efficient compared with PGE(2). Prostaglandins E 27-30 interleukin 6 Homo sapiens 52-56 25787755-5 2015 In CD40L-stimulated cells the anthocyanin and its phase II metabolites reduced IL-6 protein production, where protocatechuic acid-4-sulfate induced the greatest reduction (>96% reduction, p <= 0.03). protocatechuic acid-4-sulfate 110-139 interleukin 6 Homo sapiens 79-83 12578976-8 2003 Furthermore, although both PGE(2) and PGE(3) induce IL-6 synthesis in RAW 264.7 macrophages, PGE(3) is substantially less efficient compared with PGE(2). Prostaglandins E 38-41 interleukin 6 Homo sapiens 52-56 12578976-8 2003 Furthermore, although both PGE(2) and PGE(3) induce IL-6 synthesis in RAW 264.7 macrophages, PGE(3) is substantially less efficient compared with PGE(2). Prostaglandins E 38-41 interleukin 6 Homo sapiens 52-56 12578976-8 2003 Furthermore, although both PGE(2) and PGE(3) induce IL-6 synthesis in RAW 264.7 macrophages, PGE(3) is substantially less efficient compared with PGE(2). Prostaglandins E 38-41 interleukin 6 Homo sapiens 52-56 14603501-4 2003 Significant reductions in the MDR1-mediated efflux of Rhodamine 123 and MDR1 mRNA levels were observed in HuH 7 cells treated with IL-6, TNF-alpha, or IL-1beta and in TNF-alpha-treated HepG2 cells. Rhodamine 123 54-67 interleukin 6 Homo sapiens 131-135 12968214-9 2003 Pearson product-moment correlations revealed positive correlations at 90-km between F (2)-isoprostane and IL-6 (r = 0.31, p = 0.048), IL-10 (r = 0.31, p = 0.050), and IL-8 (r = 0.43, p = 0.005), but no other significant relationships between immune and oxidative stress indicators at 90-km and post-race. F2-Isoprostanes 84-101 interleukin 6 Homo sapiens 106-110 12393542-2 2003 In this study, we demonstrate that the specific p38 MAPK inhibitor VX-745 inhibits interleukin 6 (IL-6) and vascular endothelial growth factor (VEGF) secretion in bone marrow stromal cells (BMSCs), without affecting their viability. VX-745 67-73 interleukin 6 Homo sapiens 83-96 25995631-0 2015 Oxidative stress by layered double hydroxide nanoparticles via an SFK-JNK and p38-NF-kappaB signaling pathway mediates induction of interleukin-6 and interleukin-8 in human lung epithelial cells. hydroxide ion 35-44 interleukin 6 Homo sapiens 132-145 12393542-2 2003 In this study, we demonstrate that the specific p38 MAPK inhibitor VX-745 inhibits interleukin 6 (IL-6) and vascular endothelial growth factor (VEGF) secretion in bone marrow stromal cells (BMSCs), without affecting their viability. VX-745 67-73 interleukin 6 Homo sapiens 98-102 12393542-4 2003 Importantly, VX-745 inhibits both MM cell proliferation and IL-6 secretion in BMSCs triggered by adherence of MM cells to BMSCs, suggesting that it can inhibit paracrine MM cell growth in the BM milieu and overcome cell adhesion-related drug resistance. VX-745 13-19 interleukin 6 Homo sapiens 60-64 12483712-4 2003 PMMA had a negative effect on osteoblasts, whereas PMMA+alpha-TCP enhanced production of ALP, PICP, OC and TGFbeta-1, and reduced IL-6 levels. Polymethyl Methacrylate 51-55 interleukin 6 Homo sapiens 130-134 12923492-11 2003 Ex vivo IL-6 production was greatest in individuals who were homozygous for the haplotype containing guanine at -597 and -174. Guanine 101-108 interleukin 6 Homo sapiens 8-12 12923492-12 2003 IL-6 production was least for individuals homozygous for the haplotype containing adenine at -597 and cytosine at -174. Adenine 82-89 interleukin 6 Homo sapiens 0-4 12923492-12 2003 IL-6 production was least for individuals homozygous for the haplotype containing adenine at -597 and cytosine at -174. Cytosine 102-110 interleukin 6 Homo sapiens 0-4 12873450-1 2003 The objective of the study was to investigate the effects of baicalin, baicalein, and wogonin (plant flavonoids) on interleukin-6 (IL-6) and interleukin-8 (IL-8) protein production, mRNA expression, and nuclear factor-kappaB (NF-kappaB) binding activities induced by interleukin-1beta (IL-1beta) in human retinal pigment epithelial cell line (ARPE-19) cells. Flavonoids 101-111 interleukin 6 Homo sapiens 116-129 12873450-1 2003 The objective of the study was to investigate the effects of baicalin, baicalein, and wogonin (plant flavonoids) on interleukin-6 (IL-6) and interleukin-8 (IL-8) protein production, mRNA expression, and nuclear factor-kappaB (NF-kappaB) binding activities induced by interleukin-1beta (IL-1beta) in human retinal pigment epithelial cell line (ARPE-19) cells. Flavonoids 101-111 interleukin 6 Homo sapiens 131-135 12891120-10 2003 In contrast, PGE(2) or 11-deoxy-PGE(1) stimulated secretion of IL-6 from aortic macrophages. Prostaglandins E 13-16 interleukin 6 Homo sapiens 63-67 25681539-5 2015 The endothelial production of high-glucose-induced interleukin (IL)-4, IL-6, IL-13 and signal transducer and activator of transcription-3 (STAT-3) phosphorylation were significantly inhibited by the pretreatment with GA at concentrations of 10, 15 and 20muM based on enzyme-linked immunosorbent assay (ELISA), western blot or/and RT-PCR experiments. ginkgolide A 217-219 interleukin 6 Homo sapiens 71-75 12891120-11 2003 CONCLUSIONS: In aortic explants, PGE(2) stimulates IL-6 secretion by activation of EP4 receptors, present in macrophages. Prostaglandins E 33-36 interleukin 6 Homo sapiens 51-55 12427122-6 2002 RESULTS: Endocytosis of LCs induced the release of interleukins (IL) IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1); however, there was considerable variability among the six different LCs. lcs 24-27 interleukin 6 Homo sapiens 69-73 26066604-5 2015 Quercetin and RES decreased IL-6 and IP-10 secretion in a dose-dependent manner in both cell lines. Quercetin 0-9 interleukin 6 Homo sapiens 28-32 12414784-2 2002 Low concentrations of warfarin inhibit interleukin-6 production and phosphorylation of I-kappa B but not activation of p38 mitogen-activated protein kinase. Warfarin 22-30 interleukin 6 Homo sapiens 39-52 12509942-8 2002 PPARgamma agonists troglitazone, rosiglitazone, and 15-deoxy-Delta(12, 14)-prosglandin J(2) significantly decreased the upexpression of TNF-alpha and IL-6 in HMCL supernatants stimulated by IL-1beta. Troglitazone 19-31 interleukin 6 Homo sapiens 150-154 12509942-9 2002 Furthermore, troglitazone down-regulated TNF-alpha and IL-6 mRNA expression levels of HMCLs. Troglitazone 13-25 interleukin 6 Homo sapiens 55-59 12724357-6 2003 Alternatively, incubation of untreated 8701-BC cells with quercetin, a flavonoid known to decrease the amount of free hsf1, is found to induce upregulation of uPa and downregulation of MMP-1, and an increase of matrigel invasion by cells, thus providing further supporting data of the involvement of hsf unavailability on the modulation of uPa and MMP-1 expression and on cell invasive behaviour. Quercetin 58-67 interleukin 6 Homo sapiens 118-121 12724357-6 2003 Alternatively, incubation of untreated 8701-BC cells with quercetin, a flavonoid known to decrease the amount of free hsf1, is found to induce upregulation of uPa and downregulation of MMP-1, and an increase of matrigel invasion by cells, thus providing further supporting data of the involvement of hsf unavailability on the modulation of uPa and MMP-1 expression and on cell invasive behaviour. Flavonoids 71-80 interleukin 6 Homo sapiens 118-121 12684675-0 2003 Could exemestane affect insulin-like growth factors, interleukin 6 and bone metabolism in postmenopausal advanced breast cancer patients after failure on aminoglutethimide, anastrozole or letrozole? exemestane 6-16 interleukin 6 Homo sapiens 53-66 24930437-10 2015 In HepG2/Hep3B cells, IL-6 treatment but not IL-1beta or TNF-alpha significantly increased K8 and K18 expression and elevated K18 levels were seen after turpentine injection. Turpentine 153-163 interleukin 6 Homo sapiens 22-26 12739045-8 2003 At 4 weeks, the drop in spontaneous IL-6 and TNFalpha production was no different in the two groups, but LPS-stimulated IL-6 production was significantly lower in the MTX-treated group than the placebo group ( P<0.05). Methotrexate 167-170 interleukin 6 Homo sapiens 120-124 12379770-3 2002 This study aimed to investigate whether cerulein induced ROS generation, lipid peroxide and hydrogen peroxide production, NF-kappaB activation, and expression of cytokines (IL-1beta, IL-6) in pancreatic acinar cells. Ceruletide 40-48 interleukin 6 Homo sapiens 183-187 12739045-9 2003 CONCLUSION: Methotrexate reduces the production of IL-6 by activated cells, and this may be responsible for its anti-inflammatory property. Methotrexate 12-24 interleukin 6 Homo sapiens 51-55 25799427-9 2015 In interleukin-1beta-stimulated human chondrocytes, nitric oxide, interleukin-6 and matrix metalloproteinase 3 productions were significantly reduced by curcuminoids extract alone or in combination with hydrolyzed collagen and green tea extract. curcuminoids 153-165 interleukin 6 Homo sapiens 66-79 12594059-6 2003 In contrast, BK-induced IL-6 secretion was enhanced by exogenous prostaglandin E(2) and salmeterol. Salmeterol Xinafoate 88-98 interleukin 6 Homo sapiens 24-28 12527037-8 2003 The secretion of MCP-1 and IL-6 was markedly stimulated by TC. Taurocholic Acid 59-61 interleukin 6 Homo sapiens 27-31 12070032-10 2002 This study demonstrates that PBDCs from MM patients are functionally defective, partially because of IL-6-mediated inhibition of development. pbdcs 29-34 interleukin 6 Homo sapiens 101-105 11893605-6 2002 The same treatment resulted in increased gene and protein expression of IL-6, a response that was blocked by quercetin. Quercetin 109-118 interleukin 6 Homo sapiens 72-76 12076322-7 2002 RESULTS: We found that approximately 99% of the normal control subjects and the patients with EM, TU, or OSF had a normal serum IL-6 level less than 5.0 pg/ml. Thiouracil 98-100 interleukin 6 Homo sapiens 128-132 11779161-4 2002 We hypothesized that increased expression of COX-2, with resultant increased levels of PGE(2) in human PIN cells, activates the IL-6 signaling pathway. Prostaglandins E 87-90 interleukin 6 Homo sapiens 128-132 25830055-0 2015 Quercetin Down-regulates IL-6/STAT-3 Signals to Induce Mitochondrial-mediated Apoptosis in a Nonsmall- cell Lung-cancer Cell Line, A549. Quercetin 0-9 interleukin 6 Homo sapiens 25-29 11779161-5 2002 We demonstrate an autocrine upregulation of PGE(2) mediated by IL-6 in a human PIN cell line. Prostaglandins E 44-47 interleukin 6 Homo sapiens 63-67 11779161-6 2002 We further demonstrate that PGE(2) stimulates soluble IL-6 receptor (sIL-6R) release, gp130 dimerization, Stat-3 protein phosphorylation, and DNA binding activity. Prostaglandins E 28-31 interleukin 6 Homo sapiens 54-58 11779161-10 2002 These data provide mechanistic evidence that increased expression of COX-2/PGE(2) contributes to prostate cancer development and progression via activation of the IL-6 signaling pathway. Prostaglandins E 75-78 interleukin 6 Homo sapiens 163-167 12576957-2 2003 In a subset of acute respiratory distress syndrome patients from this trial, we performed a preliminary examination of the potential mechanisms underlying these clinical improvements by retrospectively testing the hypothesis that enteral feeding with EPA+GLA could reduce alveolar-capillary membrane protein permeability and the production of interleukin (IL)-8, IL-6, tumor necrosis factor-alpha, and leukotriene B4 that are responsible, in part, for pulmonary inflammation. epa+gla 251-258 interleukin 6 Homo sapiens 363-367 12831460-4 2003 As shown by RT-PCR, blockade of MaxiK by paxilline also inhibits induction of the mRNA of TNF-alpha and IL-6. paxilline 41-50 interleukin 6 Homo sapiens 104-108 12017294-0 2002 Interleukin-6 affects melphalan-induced DNA damage and repair in human multiple myeloma cells. Melphalan 22-31 interleukin 6 Homo sapiens 0-13 25830055-5 2015 RESULTS: Results revealed that quercetin could induce apoptosis in A549 cells through mitochondrial depolarization by causing an imbalance in B-cell lymphoma 2/ Bcl2 Antagonist X (Bcl2/Bax) ratio and by down-regulating the interleukine-6/signal transducer and activator of transcription 3 (IL-6/STAT3) signaling pathway. Quercetin 31-40 interleukin 6 Homo sapiens 290-294 12209918-7 2002 However, commercially available PMMA particles stimulated the release of necrosis factor-alpha and interleukin-6 more strongly than did retrieved particles at very high doses. Polymethyl Methacrylate 32-36 interleukin 6 Homo sapiens 99-112 25830055-6 2015 An analysis of the data revealed that quercetin could block nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) activity at early hours, which might cause a down-regulation of the IL-6 titer, and the IL-6 expression, in turn, could inhibit p-STAT3 expression. Quercetin 38-47 interleukin 6 Homo sapiens 203-207 11885806-2 2002 Our study was designed to determine whether heat shock and drugs like cisplatin, etoposide and quercetin have an effect on the expression of heat shock protein 27 in tumour cells such as: HeLa (cervical cancer), Hep-2 (larynx cancer), A549 (lung cancer) and also in normal human skin fibroblasts (HSF) cultured in two-dimensional (2D) and three-dimensional (3D) conditions. Quercetin 95-104 interleukin 6 Homo sapiens 297-300 25830055-6 2015 An analysis of the data revealed that quercetin could block nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) activity at early hours, which might cause a down-regulation of the IL-6 titer, and the IL-6 expression, in turn, could inhibit p-STAT3 expression. Quercetin 38-47 interleukin 6 Homo sapiens 223-227 25472572-4 2015 RESULTS: The in vivo results demonstrated that ICA pretreatment significantly improved I/R-induced tissue damage and decreased serum tumor necrosis factor alpha and interleukin-6 levels. icariin 47-50 interleukin 6 Homo sapiens 165-178 11710628-0 2001 Combined effects of docetaxel and fluoropyrimidines on tumor growth and expression of interleukin-6 and thymidine phosphorylase in breast cancer xenografts. Docetaxel 20-29 interleukin 6 Homo sapiens 86-99 11710628-0 2001 Combined effects of docetaxel and fluoropyrimidines on tumor growth and expression of interleukin-6 and thymidine phosphorylase in breast cancer xenografts. fluoropyrimidines 34-51 interleukin 6 Homo sapiens 86-99 11710628-9 2001 In addition, combined treatment with docetaxel and oral fluoropyrimidines may decrease serum IL-6 levels and may ameliorate IL-6-induced cancer cachexia. Docetaxel 37-46 interleukin 6 Homo sapiens 93-97 11710628-9 2001 In addition, combined treatment with docetaxel and oral fluoropyrimidines may decrease serum IL-6 levels and may ameliorate IL-6-induced cancer cachexia. Docetaxel 37-46 interleukin 6 Homo sapiens 124-128 11710628-9 2001 In addition, combined treatment with docetaxel and oral fluoropyrimidines may decrease serum IL-6 levels and may ameliorate IL-6-induced cancer cachexia. fluoropyrimidines 56-73 interleukin 6 Homo sapiens 93-97 11710628-9 2001 In addition, combined treatment with docetaxel and oral fluoropyrimidines may decrease serum IL-6 levels and may ameliorate IL-6-induced cancer cachexia. fluoropyrimidines 56-73 interleukin 6 Homo sapiens 124-128 12543079-0 2002 Effect of azacytidine in the release of leukemia inhibitory factor, oncostatin m, interleukin (IL)-6, and IL-11 by mononuclear cells of patients with refractory anemia. Azacitidine 10-21 interleukin 6 Homo sapiens 82-100 12543079-5 2002 AZA down-regulated OSM, IL-6, and IL-11 release by MNC of patients but not by MNC from healthy individuals. Azacitidine 0-3 interleukin 6 Homo sapiens 24-28 12543079-9 2002 We conclude that: (a) AZA inhibits the release of OSM, IL-6, and IL-11 exclusively in RA-diseased MNC, (b) Patient"s MNC release subnormal amounts of LIF, OSM, and IL-11, and (c) RA-derived monocytes probably down-regulate OSM release by phytohemagglutinin-activated MNC. Azacitidine 22-25 interleukin 6 Homo sapiens 55-59 25557539-4 2015 In this study, it was demonstrated that IC stimulation of B cells not only suppresses CpG-oligodeoxynucleotide (CpG-ODN)-induced pro-inflammatory IL-6 and IgM kappa production, but also attenuates CD40 and CD80 expression. CPG-oligonucleotide 86-110 interleukin 6 Homo sapiens 146-150 12364456-7 2002 Treatment of placental, amnion, and choriodecidual tissues with both 15d-PGJ(2) and troglitazone significantly reduced the release of lipopolysaccharide-stimulated IL-6, IL-8, and TNF-alpha (t test, P < 0.05). 15d-pgj 69-76 interleukin 6 Homo sapiens 164-168 12364456-7 2002 Treatment of placental, amnion, and choriodecidual tissues with both 15d-PGJ(2) and troglitazone significantly reduced the release of lipopolysaccharide-stimulated IL-6, IL-8, and TNF-alpha (t test, P < 0.05). Troglitazone 84-96 interleukin 6 Homo sapiens 164-168 11594799-0 2001 Effect of midazolam on interleukin-6 mRNA expression in human peripheral blood mononuclear cells in the absence of lipopolysaccharide. Midazolam 10-19 interleukin 6 Homo sapiens 23-36 25239226-6 2015 Induction of IL-6 production by IL-1beta was significantly reduced by addition of p38 MAPK (SB203580), MEK1/2 (U0126) or NF-kappaB (BAY11-7082) inhibitors, with the highest effect being observed with SB203580. 3-(4-methylphenylsulfonyl)-2-propenenitrile 132-142 interleukin 6 Homo sapiens 13-17 11594799-3 2001 The purpose of the present study was to evaluate the effect of midazolam on interleukin-6 (IL-6) response by observing mRNA expression levels in human peripheral blood mononuclear cells (PBMCs) in the absence of lipopolysaccharide (LPS). Midazolam 63-72 interleukin 6 Homo sapiens 76-89 11594799-3 2001 The purpose of the present study was to evaluate the effect of midazolam on interleukin-6 (IL-6) response by observing mRNA expression levels in human peripheral blood mononuclear cells (PBMCs) in the absence of lipopolysaccharide (LPS). Midazolam 63-72 interleukin 6 Homo sapiens 91-95 11594799-7 2001 It was found that midazolam time-dependently inhibited the IL-6 mRNA expression in PBMCs in the absence of LPS, and significantly inhibited the IL-6 mRNA expression at 1 microg/ml (P<0.05) or 10 microg/ml (P<0.01) in the absence of LPS. Midazolam 18-27 interleukin 6 Homo sapiens 59-63 11594799-7 2001 It was found that midazolam time-dependently inhibited the IL-6 mRNA expression in PBMCs in the absence of LPS, and significantly inhibited the IL-6 mRNA expression at 1 microg/ml (P<0.05) or 10 microg/ml (P<0.01) in the absence of LPS. Midazolam 18-27 interleukin 6 Homo sapiens 144-148 11594799-9 2001 These findings indicated a suppression of the IL-6 response in human PBMCs by midazolam in the absence of LPS, and suggests that midazolam has its effect not via benzodiazepine receptors, but by another mechanism. Midazolam 78-87 interleukin 6 Homo sapiens 46-50 11594799-9 2001 These findings indicated a suppression of the IL-6 response in human PBMCs by midazolam in the absence of LPS, and suggests that midazolam has its effect not via benzodiazepine receptors, but by another mechanism. Midazolam 129-138 interleukin 6 Homo sapiens 46-50 11594792-3 2001 Plasma IL-6 concentrations (92.3+/- 31.9 pg/ml) in elderly patients anesthetized with propofol and fentanyl were significantly higher at the end of the operation than that (57.9+/-36.7 pg/ml) of elderly patients anesthetized with sevoflurane and fentanyl. Fentanyl 99-107 interleukin 6 Homo sapiens 7-11 11594792-3 2001 Plasma IL-6 concentrations (92.3+/- 31.9 pg/ml) in elderly patients anesthetized with propofol and fentanyl were significantly higher at the end of the operation than that (57.9+/-36.7 pg/ml) of elderly patients anesthetized with sevoflurane and fentanyl. Fentanyl 246-254 interleukin 6 Homo sapiens 7-11 12530040-5 2002 Medroxyprogesterone acetate (MPA) may interfere with IL-6 macrophage production, possibly causing a synergistic effect in association with IL-2 and IFN-alpha. Medroxyprogesterone Acetate 0-27 interleukin 6 Homo sapiens 53-57 12181307-10 2002 The temporal profile of the post-exercise change in the IL-6 output closely resembles the changes in the outputs of glycerol and fatty acids, which we have described previously in the same adipose tissue depot. Glycerol 116-124 interleukin 6 Homo sapiens 56-60 12181308-5 2002 IL-6 infusion gave rise to increase in net glycerol release in subcutaneous adipose tissue while the net release of fatty acids did not change significantly. Glycerol 43-51 interleukin 6 Homo sapiens 0-4 12085250-13 2002 The present study indicates that patients responded to treatment of advanced breast cancer with single-agent paclitaxel or docetaxel leads to an increase in serum IFN-gamma, IL-2, IL-6, GM-CSF cytokine levels and enhancement of PBMC NK and LAK cell activity, while they both lead to a decrease of acute phase serum cytokine levels of IL-1 and TNF-alpha. Docetaxel 123-132 interleukin 6 Homo sapiens 180-184 25273157-7 2015 Treatment with levosimendan strongly attenuated IL-1beta-induced expression of IL-6 and IL-8 in HACM as well as E-selectin and ICAM-1 in ECs. Simendan 15-27 interleukin 6 Homo sapiens 79-83 12100148-5 2002 IL-6 expression was determined on paraffin-wax sections of biopsy material by means of an immunohistochemical assay. Waxes 43-46 interleukin 6 Homo sapiens 0-4 11920660-4 2002 The results showed that fucan, dextran derivatives, and heparin differentially (1) triggered interleukin-1alpha, tumor necrosis factor alpha, interleukin-6, and interleukin-8 production by monocytes in a dose-dependent manner, (2) modulated cytokine production by LPS-stimulated monocytes, and (3) specifically inhibited the binding of biotinylated LPS to monocyte membranes. fucan 24-29 interleukin 6 Homo sapiens 142-155 11432585-14 2001 The data presented in this study demonstrate that the anti-inflammatory cytokine, interleukin-10, inhibits monocyte/macrophage release of the pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-alpha in response to PMMA particle challenge in vitro. Polymethyl Methacrylate 230-234 interleukin 6 Homo sapiens 169-214 25760299-3 2015 To date, efficacy data shows superiority of IL-6 inhibition over placebo, conventional disease modifying anti-rheumatic drugs such as methotrexate, and TNF inhibition. Methotrexate 134-146 interleukin 6 Homo sapiens 44-48 11350802-9 2001 IL-6 did increase IL-1beta-induced PGE(2) formation in unstimulated cells but not in cells stimulated with arachidonic acid (AA; 10(-5) M), suggesting that IL-6 effects were mediated at the level of AA release. Prostaglandins E 35-38 interleukin 6 Homo sapiens 0-4 11350802-9 2001 IL-6 did increase IL-1beta-induced PGE(2) formation in unstimulated cells but not in cells stimulated with arachidonic acid (AA; 10(-5) M), suggesting that IL-6 effects were mediated at the level of AA release. Prostaglandins E 35-38 interleukin 6 Homo sapiens 156-160 12021072-8 2002 IFN-gamma and TNFalpha promote Fas expression and sensitivity, whereas IL-6 and IL-10 increase the resistance of trophoblast cells to Fas-mediated apoptosis. ammonium ferrous sulfate 134-137 interleukin 6 Homo sapiens 71-75 25434759-6 2015 Calcium citrate was furthermore found to significantly inhibit the production of IL-1beta, IL-6, and TNF-alpha in response to LPS-stimulation. Calcium Citrate 0-15 interleukin 6 Homo sapiens 91-95 12056853-10 2002 Reducing PGE(2) synthesis by Indomethacin [a cyclo-oxygenase (COX) -1 and -2 inhibitor] reduced IL-6 levels in all osteoarthritic Ob, whereas Naproxen (a more selective COX-2 inhbitor) reduced PGE(2) and IL-6 levels only in the high osteoarthritic group. Prostaglandins E 9-12 interleukin 6 Homo sapiens 96-100 12056853-11 2002 Conversely, PGE(2) addition to osteoarthritic Ob enhanced IL-6 production in both groups. Prostaglandins E 12-15 interleukin 6 Homo sapiens 58-62 12056853-15 2002 CONCLUSIONS: These results indicate that IL-6 and PGE(2) production by subchondral Ob can discriminate two subgroups of osteoarthritic patients that cannot otherwise be separated by their expression of cell markers, and that endogenous PGE(2) levels influence IL-6 synthesis in osteoarthritic Ob. Prostaglandins E 236-239 interleukin 6 Homo sapiens 41-45 12009364-10 2002 1alpha,25(OH)(2)-vitamin D(3), with or without 17beta-E(2), decreased interleukin-6 levels to 27% and 38% of control group, respectively. 1alpha 0-6 interleukin 6 Homo sapiens 70-83 11434363-0 2001 IL-6 may be the key mediator in trimethoprim-induced systemic adverse reaction and aseptic meningitis: a reply to Muller et al. Trimethoprim 32-44 interleukin 6 Homo sapiens 0-4 11344240-7 2001 On the other hand, 24-h exposure to 10 nmol/L IL-6 increased basal glycerol release by 42 +/- 12% (P < 0.01) and isoproterenol-induced glycerol release by 21 +/- 6% (P < 0.05). Glycerol 67-75 interleukin 6 Homo sapiens 46-50 11344240-7 2001 On the other hand, 24-h exposure to 10 nmol/L IL-6 increased basal glycerol release by 42 +/- 12% (P < 0.01) and isoproterenol-induced glycerol release by 21 +/- 6% (P < 0.05). Glycerol 138-146 interleukin 6 Homo sapiens 46-50 25245014-7 2015 Furthermore, the quercetin treatment diminishes IL-6 production by peritoneal cells, a cytokine important to the maintenance of B-1 cells in vitro. Quercetin 17-26 interleukin 6 Homo sapiens 48-52 11306714-5 2001 Scabronine G-ME increased the secretion of nerve growth factor (NGF) and interleukin-6 (IL-6) from 1321N1 cells with the enhancement of their mRNA expressions. scabronine g-me 0-15 interleukin 6 Homo sapiens 73-86 11306714-5 2001 Scabronine G-ME increased the secretion of nerve growth factor (NGF) and interleukin-6 (IL-6) from 1321N1 cells with the enhancement of their mRNA expressions. scabronine g-me 0-15 interleukin 6 Homo sapiens 88-92 15348300-0 2001 Interleukin-6 expression by cultured human endothelial cells in contact with carbon coated polyethylene terephthalate. carbon coated polyethylene terephthalate 77-117 interleukin 6 Homo sapiens 0-13 11289091-0 2001 Plasma levels of interleukin-6 and interleukin-10 are affected by ketorolac as an adjunct to patient-controlled morphine after abdominal hysterectomy. Ketorolac 66-75 interleukin 6 Homo sapiens 17-30 11960349-6 2002 It was shown that in AML cells cultured in the presence of Z-VAD-fmk, TGF-beta1 pretreatment resulted in a reduction of JAK1 phosphorylation upon IL-6 stimulation. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 59-68 interleukin 6 Homo sapiens 146-150 11740818-6 2001 PS-341 inhibits p44/42 mitogen-activated protein kinase (MAPK) growth signaling triggered by IL-6 and induces apoptosis, despite induction of p21 and p27, in p53 wild-type and p53 mutant MM cells. Bortezomib 0-6 interleukin 6 Homo sapiens 93-97 11740818-7 2001 PS-341 adds to the anti-MM activity of dexamethasone and overcomes IL-6-mediated protection against dexamethasone-induced apoptosis. Bortezomib 0-6 interleukin 6 Homo sapiens 67-71 11740818-8 2001 PS-341 blocks the paracrine growth of human MM cells by decreasing their adherence to BMSCs and related NF-kappaB-dependent induction of IL-6 secretion in BMSCs. Bortezomib 0-6 interleukin 6 Homo sapiens 137-141 11432585-0 2001 Interleukin-10 inhibits polymethylmethacrylate particle induced interleukin-6 and tumor necrosis factor-alpha release by human monocyte/macrophages in vitro. Polymethyl Methacrylate 24-46 interleukin 6 Homo sapiens 64-109 11289091-2 2001 Therefore, the purpose of this study was to determine differences between morphine patient-controlled analgesia and a combination of morphine and ketorolac in interleukin-6 and interleukin-10 responses, and in analgesia and morphine-related side effects. Ketorolac 146-155 interleukin 6 Homo sapiens 159-172 11432585-9 2001 Interleukin-10-induced alterations in monocyte/macrophage metabolism were determined measuring interleukin-6 and tumor necrosis factor-alpha release by the cells following exposure to PMMA particles. Polymethyl Methacrylate 184-188 interleukin 6 Homo sapiens 95-140 25245014-8 2015 Importantly, the IL-6 addition to B-1 cell culture prevents cells from apoptosis, even in the presence of quercetin. Quercetin 106-115 interleukin 6 Homo sapiens 17-21 11432585-10 2001 Exposure of the monocyte/macrophages to PMMA particles resulted in a dose-dependent release of interleukin-6 and tumor necrosis factor-alpha at 48 h. Interleukin-10 reduced the levels of interleukin-6 and tumor necrosis factor-alpha release by macrophages in response to PMMA particles in a dose-dependent manner. Polymethyl Methacrylate 40-44 interleukin 6 Homo sapiens 95-140 25842951-5 2015 RESULTS: Under the effect of DSS, expression of adhesion molecules CD162 and CD11b, as well as phospho-p38 MAPK changed, IL-6 and IL-8 secretion induction took place. dss 29-32 interleukin 6 Homo sapiens 121-125 11432585-10 2001 Exposure of the monocyte/macrophages to PMMA particles resulted in a dose-dependent release of interleukin-6 and tumor necrosis factor-alpha at 48 h. Interleukin-10 reduced the levels of interleukin-6 and tumor necrosis factor-alpha release by macrophages in response to PMMA particles in a dose-dependent manner. Polymethyl Methacrylate 40-44 interleukin 6 Homo sapiens 187-232 11432585-10 2001 Exposure of the monocyte/macrophages to PMMA particles resulted in a dose-dependent release of interleukin-6 and tumor necrosis factor-alpha at 48 h. Interleukin-10 reduced the levels of interleukin-6 and tumor necrosis factor-alpha release by macrophages in response to PMMA particles in a dose-dependent manner. Polymethyl Methacrylate 271-275 interleukin 6 Homo sapiens 95-140 11432585-10 2001 Exposure of the monocyte/macrophages to PMMA particles resulted in a dose-dependent release of interleukin-6 and tumor necrosis factor-alpha at 48 h. Interleukin-10 reduced the levels of interleukin-6 and tumor necrosis factor-alpha release by macrophages in response to PMMA particles in a dose-dependent manner. Polymethyl Methacrylate 271-275 interleukin 6 Homo sapiens 187-232 11424089-4 2001 Our finding that a bioflavonoid quercetin (QCT), a well known inhibitor of hsp gene expression, significantly inhibited the transcriptional activation of HSF and HIF-1 strongly suggests that QCT-sensitive molecule(s) is involved in the transcriptional activation of HSF and HIF-1 by hypoxia. Flavonoids 19-31 interleukin 6 Homo sapiens 154-157 11160233-4 2001 In addition, PTX-B strongly inhibited X4 HIV-1 replication in U937 promonocytic cells and virus expression in the U937-derived chronically infected U1 cell line stimulated with cytokines such as TNF-alpha and IL-6. pumiliotoxin B 13-18 interleukin 6 Homo sapiens 209-213 11104733-5 2000 Moreover, stimulation with PGE(2), forskolin, or dibutyryl cAMP alone increased basal IL-6 secretion in a concentration-dependent manner. Prostaglandins E 27-30 interleukin 6 Homo sapiens 86-90 11104733-5 2000 Moreover, stimulation with PGE(2), forskolin, or dibutyryl cAMP alone increased basal IL-6 secretion in a concentration-dependent manner. Colforsin 35-44 interleukin 6 Homo sapiens 86-90 11424089-4 2001 Our finding that a bioflavonoid quercetin (QCT), a well known inhibitor of hsp gene expression, significantly inhibited the transcriptional activation of HSF and HIF-1 strongly suggests that QCT-sensitive molecule(s) is involved in the transcriptional activation of HSF and HIF-1 by hypoxia. Flavonoids 19-31 interleukin 6 Homo sapiens 266-269 11424089-4 2001 Our finding that a bioflavonoid quercetin (QCT), a well known inhibitor of hsp gene expression, significantly inhibited the transcriptional activation of HSF and HIF-1 strongly suggests that QCT-sensitive molecule(s) is involved in the transcriptional activation of HSF and HIF-1 by hypoxia. Quercetin 32-41 interleukin 6 Homo sapiens 154-157 25409241-6 2014 The AT and TT genotypes of IFN-gamma and GG genotype of IL-6 were found to be significantly associated with CIU. n-cyclohexyl-n'-(4-iodophenyl)urea 108-111 interleukin 6 Homo sapiens 56-60 11424089-4 2001 Our finding that a bioflavonoid quercetin (QCT), a well known inhibitor of hsp gene expression, significantly inhibited the transcriptional activation of HSF and HIF-1 strongly suggests that QCT-sensitive molecule(s) is involved in the transcriptional activation of HSF and HIF-1 by hypoxia. Quercetin 32-41 interleukin 6 Homo sapiens 266-269 11426771-6 2001 Interleukin 1beta, interleukin 6, and interleukin 8 levels after cardiopulmonary bypass were significantly (p < 0.05) lower in the colforsin group. Colforsin 134-143 interleukin 6 Homo sapiens 19-32 10994781-9 2000 The administration of both IL-6 and GM-CSF induced cell-proliferation activities estimated by both [3H]-thymidine and bromodeoxyuridine labeling. 3h]-thymidine 100-113 interleukin 6 Homo sapiens 27-31 10873159-7 2000 Release of IL-6 elicited by TNF-alpha was significantly inhibited by dexamethasone, cycloheximide, and nordihydroguaiaretic acid (NDGA). Masoprocol 103-128 interleukin 6 Homo sapiens 11-15 10873159-7 2000 Release of IL-6 elicited by TNF-alpha was significantly inhibited by dexamethasone, cycloheximide, and nordihydroguaiaretic acid (NDGA). Masoprocol 130-134 interleukin 6 Homo sapiens 11-15 25409241-8 2014 In addition to this, association studies have revealed that TT genotype of IFN-gamma +874 T/A and GG genotype of IL-6-174 G/C were susceptible towards the CIU. n-cyclohexyl-n'-(4-iodophenyl)urea 155-158 interleukin 6 Homo sapiens 113-117 11357999-4 2000 Both the replication of DV and the production of IL-6 and IL-8 by HUVEC after DV infection were inhibited by ribavirin, an antiviral synthetic guanosine analogue. Ribavirin 109-118 interleukin 6 Homo sapiens 49-53 25323788-5 2014 The inflammatory-related cytokines interleukin (IL)-1beta, IL-6 and IL-8 were detected after pretreatment with the alpha1/beta2-AR blockers phentolamine/propranolol, both in vitro and in vivo. Phentolamine 140-152 interleukin 6 Homo sapiens 59-63 10926144-5 2000 TNFalpha was removed to some extent by using PS, and IL-6 was partially removed by using PMMA during experimental HF through other mechanisms, such as adsorption, than the filtration. Polymethyl Methacrylate 89-93 interleukin 6 Homo sapiens 53-57 10816606-6 2000 Indeed, the cAMP agonist forskolin increased the binding of the transcription factors NF-IL-6 and C/EBPdelta to the CAAT box of the IL-6 promoter in nuclear extracts of astrocytes. Colforsin 25-34 interleukin 6 Homo sapiens 89-93 10816606-7 2000 Inhibition of the de novo synthesis of NF-IL-6 by cycloheximide or an antisense oligonucleotide reduced the enhancement of NF-IL-6 binding to the CAAT box and inhibited stimulation of IL-6 transcription by forskolin. Colforsin 206-215 interleukin 6 Homo sapiens 42-46 11290798-8 2001 In addition, N-acetylglucosamine also suppresses the production of IL-1beta-induced cyclooxygenase-2 and IL-6. Acetylglucosamine 13-32 interleukin 6 Homo sapiens 105-109 24387017-4 2001 Mizoribine (1.25-5 mug/ml) was able to inhibit the spontaneous production of IL-6 by fresh RSC in a dose-response fashion. rsc 91-94 interleukin 6 Homo sapiens 77-81 24387017-9 2001 These data suggest that mizoribine inhibits IL-6 production by fresh RSC, possibly owing to the depletion of intracellular GMP, and that this inhibitory effect of the drug on rheumatoid synovial cells may be related to its efficacy in RA. rsc 69-72 interleukin 6 Homo sapiens 44-48 25379480-3 2014 OBJECTIVE: To evaluate any possible correlation of IL-18 and IL-6 cytokines with the clinical disease severity in chronic idiopathic urticaria (CIU). n-cyclohexyl-n'-(4-iodophenyl)urea 144-147 interleukin 6 Homo sapiens 61-65 11236942-5 2001 An interleukin-6-dependent myeloma cell line ANBL6 was used and treated with dexamethasone, doxorubicin, and melphalan in the presence of bone marrow stromal cells. Melphalan 109-118 interleukin 6 Homo sapiens 3-16 11313947-5 2001 DNA synthesis assay determined using (3)H-thymidine pulse incorporation revealed that IL-6-expressing BCC cells exhibited a much higher DNA synthesis rate than the neo control or parental BCC cells. h-thymidine 40-51 interleukin 6 Homo sapiens 86-90 10858210-0 2000 Peptidoglycan and lipoteichoic acid from Staphylococcus aureus induce tumor necrosis factor alpha, interleukin 6 (IL-6), and IL-10 production in both T cells and monocytes in a human whole blood model. lipoteichoic acid 18-35 interleukin 6 Homo sapiens 114-118 10858210-9 2000 LTA, as well as lipopolysaccharide, induced IL-6 and IL-10 mRNA production in monocytes and possibly in T cells. lipoteichoic acid 0-3 interleukin 6 Homo sapiens 44-48 10925751-9 2000 There is also an increase in interleukin-6-induced osteoclastic bone resorption, which is the rationale for treating these patients with bisphosphonates. Diphosphonates 137-152 interleukin 6 Homo sapiens 29-42 11313947-6 2001 We also detected a greater abundance of IL-6-expressing cell colonies formed in soft agar than in the vector control cells. Agar 85-89 interleukin 6 Homo sapiens 40-44 25379480-4 2014 METHODS: IL-18 and IL-6 levels of CIU patients (n = 62) and healthy controls (n = 27) were assessed by commercially available enzyme linked immunosorbent assay kits following the manufacturer"s protocols. n-cyclohexyl-n'-(4-iodophenyl)urea 34-37 interleukin 6 Homo sapiens 19-23 11394246-7 2001 DCA lowered the plasma lactate and increased plasma IL-6 concentrations at rest. Dichloroacetic Acid 0-3 interleukin 6 Homo sapiens 52-56 10888709-4 2000 RESULTS: PBMNC of RA patients showing >/= 20% improvement of the Paulus index after 3 months of MTX treatment (responders; n = 16) exhibited a significantly enhanced production of spontaneous TIMP-1 ex vivo which was associated with the enhanced synthesis of IL-6. Methotrexate 99-102 interleukin 6 Homo sapiens 262-266 10888709-8 2000 Moreover, PBMNC of healthy donors revealed that MTX also stimulated TIMP-1 and IL-6 release in vitro, IL-6 being partially responsible for the induction of TIMP-1 production. Methotrexate 48-51 interleukin 6 Homo sapiens 79-83 25379480-7 2014 Similarly, serum IL-6 concentration (0.82 +- 4.6 pg/mL) in CIU patients and in healthy controls (0.12 +- 1.7 pg/mL), showed no statistical significance (p > 0.05). n-cyclohexyl-n'-(4-iodophenyl)urea 59-62 interleukin 6 Homo sapiens 17-21 10888709-8 2000 Moreover, PBMNC of healthy donors revealed that MTX also stimulated TIMP-1 and IL-6 release in vitro, IL-6 being partially responsible for the induction of TIMP-1 production. Methotrexate 48-51 interleukin 6 Homo sapiens 102-106 11394246-8 2001 IL-6 increased in response to exercise only during DCA treatment. Dichloroacetic Acid 51-54 interleukin 6 Homo sapiens 0-4 25251539-0 2014 Oxidized lipids and lysophosphatidylcholine induce the chemotaxis, up-regulate the expression of CCR9 and CXCR4 and abrogate the release of IL-6 in human monocytes. Lysophosphatidylcholines 20-43 interleukin 6 Homo sapiens 140-144 11293246-6 2000 Thanks to clinical studies it has been performed that MTX holds up activity and productions of Il-8, releasing of TNF-alpha and reduction of concentration Il-6. Methotrexate 54-57 interleukin 6 Homo sapiens 155-159 10888709-9 2000 CONCLUSIONS: Both ex vivo and in vitro, the enhanced TIMP-1 production by PBMNC of RA patients and healthy individuals upon MTX treatment is associated with simultaneously enhanced IL-6 release, and enhanced ex vivo production of both is clearly associated with short-term clinical efficacy. Methotrexate 124-127 interleukin 6 Homo sapiens 181-185 10785230-10 2000 CONCLUSION: Retinoids may play a fundamental role in altering the pathophysiology of endometriosis related to aberrant production of IL-6. Retinoids 12-21 interleukin 6 Homo sapiens 133-137 10830783-9 2000 The proportion of apoptotic cells in X/XOD-treated LCL culture was decreased with IL-6 pretreatment by quantification with flow cytometric analysis. dextramycine 51-54 interleukin 6 Homo sapiens 82-86 25251539-7 2014 Finally, 9-S-HODE, 9-R-HODE, 13-R-HODE, or LPC inhibited the release of IL-6 from monocytes suggesting that these lipids may play important role in controlling inflammatory responses. 9-hydroxy-10,12-octadecadienoic acid 9-17 interleukin 6 Homo sapiens 72-76 24925806-6 2014 While several inhibitors are available for caspase-1 blocking experiments, in this study we show effects of two commonly used caspase inhibitors: z-VAD-fmk and ac-YVAD-cmk on secretion of pro-inflammatory cytokines: IL-1beta, TNFalpha, IL-8 and IL-6 in whole blood stimulated with LPS. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 146-155 interleukin 6 Homo sapiens 245-249 10727940-5 2000 Only (hexaacyl) lipid A with a conical/concave shape, the cross-section of the hydrophobic region being larger than that of the hydrophilic region, exhibited strong interleukin-6 (IL-6)-inducing capacity. (hexaacyl) 5-15 interleukin 6 Homo sapiens 165-178 11099064-13 2000 CONCLUSION: Our data suggest that serum level(s) of IL-6 and/or C5b-9 taken prior to the initiation of IFN treatment may serve as surrogate marker(s) in evaluating patients with chronic hepatitis C whether to get IFN alpha in monotherapy or to consider having combination therapy in the form of IFN alpha-ribavirin. Ribavirin 305-314 interleukin 6 Homo sapiens 52-56 10880077-0 2000 G-protein activity requirement for polymethylmethacrylate and titanium particle-induced fibroblast interleukin-6 and monocyte chemoattractant protein-1 release in vitro. Polymethyl Methacrylate 35-57 interleukin 6 Homo sapiens 99-112 10880077-7 2000 Exposure of fibroblasts to titanium and polymethylmethacrylate (PMMA) particles resulted in a dose-dependent release of MCP-1 and IL-6. Polymethyl Methacrylate 40-62 interleukin 6 Homo sapiens 130-134 10880077-7 2000 Exposure of fibroblasts to titanium and polymethylmethacrylate (PMMA) particles resulted in a dose-dependent release of MCP-1 and IL-6. Polymethyl Methacrylate 64-68 interleukin 6 Homo sapiens 130-134 10727940-5 2000 Only (hexaacyl) lipid A with a conical/concave shape, the cross-section of the hydrophobic region being larger than that of the hydrophilic region, exhibited strong interleukin-6 (IL-6)-inducing capacity. (hexaacyl) 5-15 interleukin 6 Homo sapiens 180-184 10727940-5 2000 Only (hexaacyl) lipid A with a conical/concave shape, the cross-section of the hydrophobic region being larger than that of the hydrophilic region, exhibited strong interleukin-6 (IL-6)-inducing capacity. Lipid A 16-23 interleukin 6 Homo sapiens 165-178 10727940-5 2000 Only (hexaacyl) lipid A with a conical/concave shape, the cross-section of the hydrophobic region being larger than that of the hydrophilic region, exhibited strong interleukin-6 (IL-6)-inducing capacity. Lipid A 16-23 interleukin 6 Homo sapiens 180-184 10727940-6 2000 Most strikingly, a correlation between a cylindrical molecular shape of lipid A and antagonistic activity was established: IL-6 induction by enterobacterial LPS was inhibited by cylindrically shaped lipid A except for compounds with reduced headgroup charge. Lipid A 72-79 interleukin 6 Homo sapiens 123-127 10971177-0 2000 An analysis of serum interleukin-6 levels to predict benefits of medroxyprogesterone acetate in advanced or recurrent breast cancer. Medroxyprogesterone Acetate 65-92 interleukin 6 Homo sapiens 21-34 24925806-6 2014 While several inhibitors are available for caspase-1 blocking experiments, in this study we show effects of two commonly used caspase inhibitors: z-VAD-fmk and ac-YVAD-cmk on secretion of pro-inflammatory cytokines: IL-1beta, TNFalpha, IL-8 and IL-6 in whole blood stimulated with LPS. ac-yvad 160-167 interleukin 6 Homo sapiens 245-249 10704257-14 2000 Thus, RA inhibition of IL-6 production in normal human osteoblasts may contribute to the bone abnormalities seen after systemic long-term retinoid therapy in some patients. Retinoids 138-146 interleukin 6 Homo sapiens 23-27 10727940-6 2000 Most strikingly, a correlation between a cylindrical molecular shape of lipid A and antagonistic activity was established: IL-6 induction by enterobacterial LPS was inhibited by cylindrically shaped lipid A except for compounds with reduced headgroup charge. Lipid A 199-206 interleukin 6 Homo sapiens 123-127 10708808-0 2000 Methotrexate suppresses the interleukin-6 induced generation of reactive oxygen species in the synoviocytes of rheumatoid arthritis. Methotrexate 0-12 interleukin 6 Homo sapiens 28-41 10888268-4 2000 The H1 histamine receptor antagonist triprolidine decreased gene expression and biosynthesis of IL-6, while other histamine receptor antagonists had no effect. Triprolidine 37-49 interleukin 6 Homo sapiens 96-100 24925806-7 2014 We demonstrate ac-YVAD-cmk is a specific caspase-1 inhibitor resulting in pronounced decreases in IL-1beta and less suppression of TNFalpha, IL-6 and IL-8, while pan-caspase inhibitor, z-VAD-fmk, only weakly suppressed Il-1beta while acting strongly on the other three cytokines. ac-yvad 15-22 interleukin 6 Homo sapiens 141-145 10613737-10 2000 Blocking antibodies against TNF-alpha, IL-1beta, and IL-6 restored the diminished [(3)H]TC uptake in cells exposed to TCC and CM to 87% and 107% of controls, respectively. Triclocarban 118-121 interleukin 6 Homo sapiens 53-57 10708808-5 2000 These spontaneous and augmented IL-6 expressions or productions were suppressed by treatment with low-concentration of MTX (1 microg/ml). Methotrexate 119-122 interleukin 6 Homo sapiens 32-36 10708808-6 2000 Also, IL-6 stimulated the proliferation of FLSs, and this IL-6 driven proliferation was inhibited with the treatment of MTX or N-acetylcysteine (NAC, 1 mM). Methotrexate 120-123 interleukin 6 Homo sapiens 6-10 24939178-7 2014 Together, our data provide a novel explanation that high level of IL6 stimulated SOD2 expression that, at least partially, contributed to the low level of ROS that would likely result in a sustained increase in the expression of IGF-1R through abolishment of beta-arrestin1 in docetaxel resistant cells. Docetaxel 277-286 interleukin 6 Homo sapiens 66-69 10708808-6 2000 Also, IL-6 stimulated the proliferation of FLSs, and this IL-6 driven proliferation was inhibited with the treatment of MTX or N-acetylcysteine (NAC, 1 mM). Methotrexate 120-123 interleukin 6 Homo sapiens 58-62 25002964-6 2014 RESULTS: Probiotic supplementation was associated with decreased LTA (lipoteichoic acid) induced CCL4, CXCL8, IL-1beta and IL-6 responses at 12 months and decreased CCL4 and IL-1beta secretion at 24 months. lipoteichoic acid 70-87 interleukin 6 Homo sapiens 123-127 10708808-7 2000 Furthermore, ROS production in FLSs was increased significantly by IL-6, and its effect was also abrogated in the presence of MTX or NAC. Methotrexate 126-129 interleukin 6 Homo sapiens 67-71 10708808-8 2000 These results suggest that inflammatory reaction in the synovium of RA patients could be augmented by the autocrine or other cytokine-induced production of IL-6 with subsequent generation of ROS in the synoviocytes, and the modulations of IL-6 synthesis and ROS production may contribute to the therapeutic effects of MTX for RA. Methotrexate 318-321 interleukin 6 Homo sapiens 156-160 10708808-8 2000 These results suggest that inflammatory reaction in the synovium of RA patients could be augmented by the autocrine or other cytokine-induced production of IL-6 with subsequent generation of ROS in the synoviocytes, and the modulations of IL-6 synthesis and ROS production may contribute to the therapeutic effects of MTX for RA. Methotrexate 318-321 interleukin 6 Homo sapiens 239-243 10588224-11 1999 CONCLUSIONS: In patients with severe CHF, high-dose enalapril therapy is associated with a significant decrease in IL-6 activity. Enalapril 52-61 interleukin 6 Homo sapiens 115-119 10614715-8 1999 MTX + EtOH increased the release of IL 6, IL 8 and TNF alpha by 1.0, 1.2, and 1.1 times, respectively. Methotrexate 0-3 interleukin 6 Homo sapiens 36-40 10722595-4 2000 Both the fever and the increased levels of IL-1, TNF, IFN-gamma, IL-2, and IL-6 in supernatant fluids obtained from the SEA-stimulated PBMC were decreased by incubating SEA-PBMC with anisomycin (a protein synthesis inhibitor), aminoguanidine (an inhibitor of inducible nitric oxide synthase [NOS]), or dexamethasone (an inhibitor of NOS). pimagedine 227-241 interleukin 6 Homo sapiens 75-79 10599049-11 1999 In conclusion, our study supports the contention that the antiresorptive effect of bisphosphonates may be due in part to a decrease in IL-6 production by osteoblasts. Diphosphonates 83-98 interleukin 6 Homo sapiens 135-139 24713927-6 2014 Combining MLN4924 with the proteasome inhibitor bortezomib induces synergistic apoptosis in MM cell lines which can overcome the prosurvival effects of growth factors such as interleukin-6 and insulin-like growth factor-1. Bortezomib 48-58 interleukin 6 Homo sapiens 175-221 24631018-8 2014 A minimum concentration of ZnO2 nanoparticles of 1 mug/mL inhibited the production of two inflammatory cytokines: interleukin-1-beta and interleukin 6 by peripheral blood mononuclear cells in the presence of lipopolysaccharides. zno2 27-31 interleukin 6 Homo sapiens 137-150 10501085-5 1999 The specific inhibitor CA074Me was the least effective in slowing the intracellular processing of IL-6. CA 074 methyl ester 23-30 interleukin 6 Homo sapiens 98-102 10455136-7 1999 The present study shows that (i) mannose 6-phosphate-containing LIF is naturally produced by a number of normal and tumor cell lines; (ii) other cytokines in the interleukin-6 family do not bind to Man-6-P/IGFII-R; and (iii) another unrelated cytokine, macrophage-colony-stimulating factor, is also able to bind to Man-6-P/IGFII-R in a mannose 6-phosphate-sensitive manner. mannose-6-phosphate 33-52 interleukin 6 Homo sapiens 162-175 10679106-0 2000 Lipoxin A4 inhibits IL-1 beta-induced IL-6, IL-8, and matrix metalloproteinase-3 production in human synovial fibroblasts and enhances synthesis of tissue inhibitors of metalloproteinases. lipoxin A4 0-10 interleukin 6 Homo sapiens 38-42 10679106-6 2000 At nanomolar concentrations, LXA4 inhibited these IL-1 beta responses with reduction of IL-6 and IL-8 synthesis, by 45 +/- 7% and 75 +/- 11%, respectively, and prevented IL-1 beta-induced MMP-3 synthesis without significantly affecting MMP-1 levels. lipoxin A4 29-33 interleukin 6 Homo sapiens 88-92 10671814-4 2000 However, the increases in PGE(2) production by IL-6 and IL-8 were found at relatively high concentrations, i.e. at 100 and 200 ng/ml. Prostaglandins E 26-29 interleukin 6 Homo sapiens 47-51 10397515-3 1999 The aims of this in vitro study were to assess, in the presence or absence of testosterone (T) or dihydrotestosterone (DHT), the production of interleukin-6 (IL-6) by human gingival fibroblasts (hGF), and to evaluate the effects of flutamide (a common anti-androgen) in this system. Flutamide 232-241 interleukin 6 Homo sapiens 158-162 24885636-9 2014 This response was attenuated by treating TAMs with the KCNN4 channel-specific inhibitor, 1-[(2-chlorophenyl) diphenylmethyl]-1H-pyrazole (TRAM-34), which suggested that KCNN4 channels may be involved in inducing the secretion of IL-6 and IL-8 by TAMs and improving CRC cell invasiveness. TRAM 34 89-136 interleukin 6 Homo sapiens 229-233 10362412-0 1999 Effect of the nitric oxide inhibitor, L-N(G)-monomethylarginine, on accumulation of interleukin-6 and interleukin-8, and nuclear factor-kappaB activity in a human endothelial cell line. l-n(g)-monomethylarginine 38-63 interleukin 6 Homo sapiens 84-97 24755610-11 2014 CONCLUSIONS: This study shows that the HFR-Supra cartridge retains total p-cresol and IL-6 in the ultrafiltrate and lowers plasma total p cresol but not IL-6 levels. cresol 138-144 interleukin 6 Homo sapiens 86-90 10362412-1 1999 OBJECTIVE: To determine the effect of the nitric oxide synthase inhibitor, L-N(G)-monomethylarginine, on interleukin-6 and interleukin-8 accumulation, and nuclear factor-kappaB expression in an endothelial cell model of sepsis. l-n(g)-monomethylarginine 75-100 interleukin 6 Homo sapiens 105-118 10585421-2 1999 Treatment of primary rat hepatocytes or tranfected HepG2 cells with the alpha(1B)-adrenergic receptor (alpha(1B)AR) agonist phenylephrine (PE) significantly inhibited interleukin 6 (IL-6)-induced STAT3 binding, tyrosine phosphorylation, and IL-6-induced serum amyloid A mRNA expression. Phenylephrine 124-137 interleukin 6 Homo sapiens 167-180 10585421-2 1999 Treatment of primary rat hepatocytes or tranfected HepG2 cells with the alpha(1B)-adrenergic receptor (alpha(1B)AR) agonist phenylephrine (PE) significantly inhibited interleukin 6 (IL-6)-induced STAT3 binding, tyrosine phosphorylation, and IL-6-induced serum amyloid A mRNA expression. Phenylephrine 124-137 interleukin 6 Homo sapiens 182-186 10585421-2 1999 Treatment of primary rat hepatocytes or tranfected HepG2 cells with the alpha(1B)-adrenergic receptor (alpha(1B)AR) agonist phenylephrine (PE) significantly inhibited interleukin 6 (IL-6)-induced STAT3 binding, tyrosine phosphorylation, and IL-6-induced serum amyloid A mRNA expression. Phenylephrine 124-137 interleukin 6 Homo sapiens 241-245 24576880-6 2014 The cell types tested, except HSF, are able to convert inactive 25-hydroxyvitamin D3 (25[OH]D3) into active 1,25-hydroxyvitamin D3 (1,25[OH]2D3). [oh]d3 88-94 interleukin 6 Homo sapiens 30-33 10585421-2 1999 Treatment of primary rat hepatocytes or tranfected HepG2 cells with the alpha(1B)-adrenergic receptor (alpha(1B)AR) agonist phenylephrine (PE) significantly inhibited interleukin 6 (IL-6)-induced STAT3 binding, tyrosine phosphorylation, and IL-6-induced serum amyloid A mRNA expression. Phenylephrine 139-141 interleukin 6 Homo sapiens 167-180 10585421-2 1999 Treatment of primary rat hepatocytes or tranfected HepG2 cells with the alpha(1B)-adrenergic receptor (alpha(1B)AR) agonist phenylephrine (PE) significantly inhibited interleukin 6 (IL-6)-induced STAT3 binding, tyrosine phosphorylation, and IL-6-induced serum amyloid A mRNA expression. Phenylephrine 139-141 interleukin 6 Homo sapiens 182-186 10585421-2 1999 Treatment of primary rat hepatocytes or tranfected HepG2 cells with the alpha(1B)-adrenergic receptor (alpha(1B)AR) agonist phenylephrine (PE) significantly inhibited interleukin 6 (IL-6)-induced STAT3 binding, tyrosine phosphorylation, and IL-6-induced serum amyloid A mRNA expression. Phenylephrine 139-141 interleukin 6 Homo sapiens 241-245 10585421-7 1999 Taken together, these data indicate that PE inhibits IL-6 activation of STAT3 in hepatic cells by a p42/44 mitogen-activated protein kinase-dependent mechanism, and tyrosine phosphatases are involved. Phenylephrine 41-43 interleukin 6 Homo sapiens 53-57 10198211-3 1999 Vitamin D3-differentiated THP-1 cells, cultured human monocytic leukemia cells, produced a high level of interleukin-6 (IL-6) by stimulating LPS from Escherichia coli O111:B4, but not by stimulating synthetic E. coli-type lipid A (compound 506), E. coli Re mutant LPS (ReLPS), or alkali-treated LPS. Lipid A 222-229 interleukin 6 Homo sapiens 105-118 10198211-3 1999 Vitamin D3-differentiated THP-1 cells, cultured human monocytic leukemia cells, produced a high level of interleukin-6 (IL-6) by stimulating LPS from Escherichia coli O111:B4, but not by stimulating synthetic E. coli-type lipid A (compound 506), E. coli Re mutant LPS (ReLPS), or alkali-treated LPS. Lipid A 222-229 interleukin 6 Homo sapiens 120-124 9922315-6 1999 Forskolin mimicked the stimulatory effects of these neurotransmitters on IL-6 secretion, and the protein kinase inhibitor6-22 amide abolished the actions of VIP, CGRP, and norepinephrine, but not that of human recombinant IL-1beta, on IL-6 secretion. Colforsin 0-9 interleukin 6 Homo sapiens 73-77 10602426-6 1999 The propagation of week 6 CAFC was up to four-fold higher in the presence of IL-6 than with H-IL-6. cafc 26-30 interleukin 6 Homo sapiens 77-81 10602426-6 1999 The propagation of week 6 CAFC was up to four-fold higher in the presence of IL-6 than with H-IL-6. cafc 26-30 interleukin 6 Homo sapiens 94-98 24378536-6 2014 Visfatin also significantly elevated the secretion of IL-6 as well as IL-1beta in a longer incubation period, which was partially suppressed by nuclear factor-kappaB (NF-kappaB) inhibitor, BAY11-7082, and c-Jun-N-terminal kinase (JNK) inhibitor, SP600125. pyrazolanthrone 246-254 interleukin 6 Homo sapiens 54-58 24370115-1 2014 An Interleukin-6 (IL-6) electrochemical immunosensor was fabricated based on the Au nanoparticles (AuNP)-graphene-silica sol-gel as immobilization biointerface and AuNP-polydopamine (PDA)@carbon nanotubes (CNT) as the label of HRP-bound antibodies. polydopamine 169-181 interleukin 6 Homo sapiens 3-16 10400874-0 1999 Interferon-gamma exacerbates polymethylmethacrylate particle-induced interleukin-6 release by human monocyte/macrophages in vitro. Polymethyl Methacrylate 29-51 interleukin 6 Homo sapiens 69-82 10083762-12 1999 Preoperatively, HGF and CRP concentrations were positively affected by larger tumor size, and IL-6 concentration was negatively affected by hepatitis B surface antigen positivity and a higher indocyanine green (ICG) retention rate. Indocyanine Green 192-209 interleukin 6 Homo sapiens 94-98 10083762-12 1999 Preoperatively, HGF and CRP concentrations were positively affected by larger tumor size, and IL-6 concentration was negatively affected by hepatitis B surface antigen positivity and a higher indocyanine green (ICG) retention rate. Indocyanine Green 211-214 interleukin 6 Homo sapiens 94-98 10400874-5 1999 The effects of interferon-gamma were determined by measuring interleukin-6 and tumor necrosis factor-alpha release by primary human monocyte/macrophages following exposure to PMMA particles. Polymethyl Methacrylate 175-179 interleukin 6 Homo sapiens 61-106 24370115-1 2014 An Interleukin-6 (IL-6) electrochemical immunosensor was fabricated based on the Au nanoparticles (AuNP)-graphene-silica sol-gel as immobilization biointerface and AuNP-polydopamine (PDA)@carbon nanotubes (CNT) as the label of HRP-bound antibodies. polydopamine 169-181 interleukin 6 Homo sapiens 18-22 10400874-6 1999 Exposure of the monocyte/macrophages to PMMA particles resulted in a dose-dependent release of interleukin-6 and tumor necrosis factor-alpha at 48 h. The interleukin-6 release in response to PMMA particle challenge was stimulated by 76% and 127% in the presence of 1.0 and 10.0 ng/mL of interferon-gamma, respectively. Polymethyl Methacrylate 40-44 interleukin 6 Homo sapiens 95-140 10400874-6 1999 Exposure of the monocyte/macrophages to PMMA particles resulted in a dose-dependent release of interleukin-6 and tumor necrosis factor-alpha at 48 h. The interleukin-6 release in response to PMMA particle challenge was stimulated by 76% and 127% in the presence of 1.0 and 10.0 ng/mL of interferon-gamma, respectively. Polymethyl Methacrylate 40-44 interleukin 6 Homo sapiens 95-108 10467171-9 1999 These findings indicate that IL-1beta-induced IL-6 production in MG-63 cells involves the following sequence of steps: IL-1beta-induced COX-2 activation, PGE(2) production, and EP-1 receptor signaling prior to IL-6 production. Prostaglandins E 154-157 interleukin 6 Homo sapiens 46-50 12793958-0 1999 Combination of methotrexate and prednizone decreases circulating concentrations of interleukin 1 beta and Interleukin 6 in patients with rheumatoid arthritis. Methotrexate 15-27 interleukin 6 Homo sapiens 106-119 12793958-7 1999 MTX in combination with prednizone improved patient clinical status that was accompanied by 1.96-, 1.25-, and 1.35-fold decrease in IL-1 beta, IL-6 and TBARs after 6 month treatment (p<0.001), respectively. Methotrexate 0-3 interleukin 6 Homo sapiens 143-147 24375705-8 2014 Our data showed that IL-1beta markedly stimulated the expressions of iNOS and COX-2 and the productions of NO, PGE2 , and IL-6, which could be significantly reversed by honokiol. honokiol 169-177 interleukin 6 Homo sapiens 122-126 10049521-2 1998 IL-6 increases the activity of the 17beta-oxidoreductase, which converts oestrone to oestradiol, a process that may contribute to the increased concentration of oestrogen around breast tumours. Estrone 73-81 interleukin 6 Homo sapiens 0-4 9922036-8 1998 Interestingly, some studies have reported an improved survival in subsets of MM patients receiving BP and this is in agreement with recent evidence of possible direct anti-neoplastic activities of these drugs mediated through reduction of IL-6 production and stimulation of neoplastic cell apoptosis. Diphosphonates 99-101 interleukin 6 Homo sapiens 239-243 9734662-0 1998 Dexamethasone plus retinoids decrease IL-6/IL-6 receptor and induce apoptosis in myeloma cells. Retinoids 19-28 interleukin 6 Homo sapiens 38-42 10652584-6 1999 SA, as well as indomethacin (INDO), reduced the synthesis of IL-6 and -11, at both the protein and mRNA levels, in the two cell lines producing these cytokines (MDA-MB-231 and Hs578T). Salicylates 0-2 interleukin 6 Homo sapiens 61-73 10652584-7 1999 This latter effect seemed to be mediated by PGE2 since SA and INDO reduced PGE2 levels in MDA-MB-231 and Hs578T cells, PGE2 was not detected in MCF-7 and T-47D cells and exogenous PGE2 increased IL-6 and -11 expression by MDA-MB-231 cells. Salicylates 55-57 interleukin 6 Homo sapiens 195-207 10382823-10 1999 The prevalence of circulating lymphocytes responsible for the delayed hypersensitivity, namely Thl, would justify both the significant increase of TNF and the significant decrease of IL6 in unstimulated PBMC of patients, as well as the significant increase of the "index of cytokine release" after the challenge with metal ions. Orlistat 95-98 interleukin 6 Homo sapiens 183-186 9734662-0 1998 Dexamethasone plus retinoids decrease IL-6/IL-6 receptor and induce apoptosis in myeloma cells. Retinoids 19-28 interleukin 6 Homo sapiens 43-47 24655440-6 2014 RESULTS: Garcinol could inhibit both constitutive and interleukin (IL-6) inducible STAT3 activation in HCC cells. garcinol 9-17 interleukin 6 Homo sapiens 67-71 9736227-2 1998 The purpose of this paper was to examine if there were any correlations between hypoxanthine in vitreous humour and IL-6 in CSF. Hypoxanthine 80-92 interleukin 6 Homo sapiens 116-120 10228028-5 1999 Under serum-free conditions, CHO and U373 cells expressing mCD14 responded to as little as 0.1 ng/ml of LPS, as measured by NF-kappaB activation as well as ICAM and IL-6 production. cho 29-32 interleukin 6 Homo sapiens 165-169 24459190-0 2014 Blockade of visfatin induction by oleanolic acid via disturbing IL-6-TRAF6-NF-kappaB signaling of adipocytes. Oleanolic Acid 34-48 interleukin 6 Homo sapiens 64-68 10203364-7 1999 Meanwhile, puromycin, a protein synthesis inhibitor, superinduced IL-6 expression in the presence or absence of each PTHrP peptide. Puromycin 11-20 interleukin 6 Homo sapiens 66-70 9609548-4 1998 The effect of EGF and IL-6 on the growth of MNU-induced transformants isolated from soft agar was assessed both in monolayer culture and in a soft agar. Agar 89-93 interleukin 6 Homo sapiens 22-26 9563797-3 1998 The role of IL-6 in hypercalcemia and bone resorption would suggest that bisphosphonates or dexamethasone could be useful as adjuvant therapy for IL-6 dependent bone metastases which fail to respond to interferon alpha (IFN) alpha 2a and all trans retinoic acid (ATRA). Diphosphonates 73-88 interleukin 6 Homo sapiens 12-16 9563797-3 1998 The role of IL-6 in hypercalcemia and bone resorption would suggest that bisphosphonates or dexamethasone could be useful as adjuvant therapy for IL-6 dependent bone metastases which fail to respond to interferon alpha (IFN) alpha 2a and all trans retinoic acid (ATRA). Diphosphonates 73-88 interleukin 6 Homo sapiens 146-150 24459190-11 2014 These results demonstrate that oleanolic acid inhibited visfatin and its inflammatory response during adipocyte differentiation through blocking IL-6-TRAF6-NF-kappaB signaling. Oleanolic Acid 31-45 interleukin 6 Homo sapiens 145-149 24758098-2 2014 The aim of this study was to determine the production of proinflammatory cytokines IL-1beta, IL-6 y TNF-alpha in epithelial cell cultures treated with MTX. Methotrexate 151-154 interleukin 6 Homo sapiens 93-97 9527747-4 1998 The aim of the present study was to investigate if choice of anaesthesia, based on high-dose opioids (fentanyl) versus low-dose opioids influenced the release of IL-6, IL-8, and IL-10. Fentanyl 102-110 interleukin 6 Homo sapiens 162-166 11185687-9 1999 Six months after the discontinuation of low-dose weekly methotrexate, progression of neuropsychological abnormalities such as dementia was recognized, and IL-6 levels in cerebrospinal fluid were significantly increased. Methotrexate 56-68 interleukin 6 Homo sapiens 155-159 12793958-9 1999 CONCLUSIONS: MTX in combination with prednizone decreases blood levels of IL-1 beta and IL-6 and inhibits the intensity of free radical- mediated processes in RA subjects. Methotrexate 13-16 interleukin 6 Homo sapiens 88-92 9882597-5 1999 However, pretreatment of these cells with capsazepine (CPZ), an antagonist for capsaicin (i.e., vanilloid) receptors, inhibited the immediate increases in [Ca2+]i, diminished transcript (i.e., IL-6, IL-8, TNFalpha) levels and reduced IL-6 cytokine release to control levels. capsazepine 42-53 interleukin 6 Homo sapiens 193-197 9882597-5 1999 However, pretreatment of these cells with capsazepine (CPZ), an antagonist for capsaicin (i.e., vanilloid) receptors, inhibited the immediate increases in [Ca2+]i, diminished transcript (i.e., IL-6, IL-8, TNFalpha) levels and reduced IL-6 cytokine release to control levels. capsazepine 42-53 interleukin 6 Homo sapiens 234-238 23931157-4 2014 The co-incubation of the cells with Ind, at a nutritionally relevant concentration (5-25 muM), and IL-1beta prevented the release of the pro-inflammatory cytokines IL-6 and IL-8, PGE2 and NO, the formation of ROS and the loss of thiols in a dose-dependent manner. indicaxanthin 36-39 interleukin 6 Homo sapiens 164-168 9882597-5 1999 However, pretreatment of these cells with capsazepine (CPZ), an antagonist for capsaicin (i.e., vanilloid) receptors, inhibited the immediate increases in [Ca2+]i, diminished transcript (i.e., IL-6, IL-8, TNFalpha) levels and reduced IL-6 cytokine release to control levels. capsazepine 55-58 interleukin 6 Homo sapiens 193-197 9882597-5 1999 However, pretreatment of these cells with capsazepine (CPZ), an antagonist for capsaicin (i.e., vanilloid) receptors, inhibited the immediate increases in [Ca2+]i, diminished transcript (i.e., IL-6, IL-8, TNFalpha) levels and reduced IL-6 cytokine release to control levels. capsazepine 55-58 interleukin 6 Homo sapiens 234-238 9916882-6 1998 The thiazolidinediones activating the RZR/ROR(alpha) receptor (CGP 52608, CGP 53079) also increased IL-2 and IL-6 production. Thiazolidinediones 4-22 interleukin 6 Homo sapiens 109-113 9916882-7 1998 CGP 55644 had no effect on cytokine production and antagonized the effects of CGP 52608 on IL-2 and IL-6 production; moreover, CGP 55644 decreased the enhanced IL-2 production caused by melatonin. cgp 0-3 interleukin 6 Homo sapiens 100-104 9741405-4 1998 The clinical responses of the patients to MTX were judged by neuropsychiatric findings, intelligence test, brain MRI scans and cerebrospinal fluid (CSF) IL-6 levels. Methotrexate 42-45 interleukin 6 Homo sapiens 153-157 9586691-0 1998 Soluble interleukin-2 receptor and interleukin-6 levels: evaluation during cyclosporin A and methotrexate treatment in psoriatic arthritis. Methotrexate 93-105 interleukin 6 Homo sapiens 35-48 9367858-6 1997 In contrast, quercetin inhibited both HSF DNA-binding activity and HSF expression in HeLa cells. Quercetin 13-22 interleukin 6 Homo sapiens 38-41 9367858-6 1997 In contrast, quercetin inhibited both HSF DNA-binding activity and HSF expression in HeLa cells. Quercetin 13-22 interleukin 6 Homo sapiens 67-70 9367858-7 1997 Our studies suggest that quercetin"s action is cell-type specific, and in breast cancer cells may involve regulation of HSF transcriptional activity, rather than regulation of its DNA-binding activity. Quercetin 25-34 interleukin 6 Homo sapiens 120-123 9741405-8 1998 However, 6 months after discontinuation of MTX, all the six patients showed significant exacerbation of the manifestations as evidenced by a decrease in verbal intelligence quotients along with the marked elevation of CSF IL-6. Methotrexate 43-46 interleukin 6 Homo sapiens 222-226 9325067-2 1997 In the present study we assessed the effects of its precursor molecule, proCRH, on interleukin-6 (IL-6) release by human peripheral blood mononuclear cells (MNC). procrh 72-78 interleukin 6 Homo sapiens 83-96 24337644-6 2014 15d-PGJ(2) and CV3988 inhibited the LPS-induced mRNA expression and protein production of interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and intercellular adhesion molecule-1 (ICAM-1) in ARPE19 cells. 15d-pgj 0-7 interleukin 6 Homo sapiens 90-103 9325067-2 1997 In the present study we assessed the effects of its precursor molecule, proCRH, on interleukin-6 (IL-6) release by human peripheral blood mononuclear cells (MNC). procrh 72-78 interleukin 6 Homo sapiens 98-102 9325067-7 1997 The proCRH had an inhibitory effect on basal and LPS-stimulated release of IL-6. procrh 4-10 interleukin 6 Homo sapiens 75-79 9690225-9 1998 RESULTS: Compared to the control group, PBMC from uremic patients on conservative therapy and treated by CU showed a clear reduction in the cytokine release, while PMMA and PA membranes were able to normalize IL-6, IL-8 and MCP-1 protein concentration, which had been reduced by CU treatment. Polymethyl Methacrylate 164-168 interleukin 6 Homo sapiens 209-213 9563900-0 1998 Interleukin 6 differentially potentiates the antitumor effects of taxol and vinblastine in U266 human myeloma cells. Vinblastine 76-87 interleukin 6 Homo sapiens 0-13 24337644-6 2014 15d-PGJ(2) and CV3988 inhibited the LPS-induced mRNA expression and protein production of interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and intercellular adhesion molecule-1 (ICAM-1) in ARPE19 cells. 15d-pgj 0-7 interleukin 6 Homo sapiens 105-109 9563900-6 1998 In the presence of IL-6, the DNA distribution pattern induced by Taxol or vinblastine was altered. Vinblastine 74-85 interleukin 6 Homo sapiens 19-23 9563900-11 1998 In the presence of IL-6, the number of cells containing microtubule asters increased for Taxol treatment, but not for vinblastine treatment. Vinblastine 118-129 interleukin 6 Homo sapiens 19-23 24269928-6 2014 Carbachol concentration-dependently enhanced the production of IL-1beta-induced IL-6 and IL-8, which was blocked by the simultaneous addition of tiotropium. Carbachol 0-9 interleukin 6 Homo sapiens 80-84 9563900-12 1998 These data indicate that IL-6 leads to differential modulation of the cytotoxicity of Taxol and vinblastine in U266 cells. Vinblastine 96-107 interleukin 6 Homo sapiens 25-29 9563900-13 1998 Whereas recruitment of cells in the S phase of the cell cycle represents a major mechanism by which IL-6 potentiates the cytotoxicity of vinblastine, augmentation of the cytotoxicity of Taxol involves additional mechanisms. Vinblastine 137-148 interleukin 6 Homo sapiens 100-104 9584910-1 1998 The effect of the dentifrice ingredient triclosan (2,4,4"-trichloro-2"-hydroxyldiphenyl ether) on the production of interleukin (IL)-1beta and IL-6 was studied in human gingival fibroblasts challenged with tumor necrosis factor alpha (TNFalpha) in vitro. 2,4,4"-trichloro-2"-hydroxyldiphenyl ether 51-93 interleukin 6 Homo sapiens 143-147 10743092-2 1997 Significant levels of IL-6 (> 62.5 ng/L) were found in 19 (86.36%) of 22 MEEs and those of TNF-alpha (> 37.5 ng/L) in 19 (70.37%) of 27 MEEs. mees 76-80 interleukin 6 Homo sapiens 22-26 9298057-7 1997 In patients with PCNSL, levels of IL-10 exceeded those of IL-6 in 6 of 11 CSF samples with malignant cells compared with 7 of 53 samples without malignant cells (P = .01). pcnsl 17-22 interleukin 6 Homo sapiens 58-62 24449571-7 2014 CONCLUSION: The molecular similarities between the effects of TCZ, RTX, and MTX therapies in the RA synovium indicate that B cell- and IL-6-dependent pathways play synergistic roles in the pathogenesis of the disease, in particular through activation of T cell responses. Methotrexate 76-79 interleukin 6 Homo sapiens 135-139 21432455-6 1997 Thus the change rate of sialic acids (SA) increased significantly in both the IL-6 unchanged and increased groups. Sialic Acids 24-36 interleukin 6 Homo sapiens 78-82 9212976-5 1997 In hyperosmotic 150 mM NaCl or 1.0 M glycerol medium, the stress response to heat shock was inhibited at the levels of HSF activation, HSP70 mRNA accumulation, and HSP70 synthesis. Glycerol 37-45 interleukin 6 Homo sapiens 119-122 9570525-3 1998 They also inhibit IL-6 synthesis and thymidine uptake by human unfractionated PBMC induced by CpG-ODN. CPG-oligonucleotide 94-101 interleukin 6 Homo sapiens 18-22 9506876-0 1998 Bisphosphonates inhibit IL-6 production by human osteoblast-like cells. Diphosphonates 0-15 interleukin 6 Homo sapiens 24-28 23941496-4 2014 Larifan caused strong induction of chemokine macrophage inflammatory protein 1beta, I-309, and TARC, proinflammatory cytokines IL-6, tumor necrosis factor -alpha, granulocyte macrophage colony-stimulating factor, anti-inflammatory IL-10, and cellular immunity mediating factors IL-23 and interferon-gamma. larifan 0-7 interleukin 6 Homo sapiens 127-161 9328832-13 1997 These results demonstrate PTH, forskolin, the PTHrP analog RS-66271, and IL-1 alpha stimulate IL-6 expression by stimulating gene transcription. Colforsin 31-40 interleukin 6 Homo sapiens 94-98 9328832-14 1997 The response to forskolin suggests that the messenger system mediated by PKA is sufficient to induce IL-6 expression. Colforsin 16-25 interleukin 6 Homo sapiens 101-105 9212976-6 1997 In vitro activation of HSF showed that inhibition of this activation by hyperosmotic NaCl or glycerol stress was not irreversible. Glycerol 93-101 interleukin 6 Homo sapiens 23-26 9169347-10 1997 Similarly, 17 beta-E2 inhibited PMA-stimulated IL-6 production, whereas neither forskolin-stimulated IL-6/ IL-11 production nor PMA-stimulated IL-11 production was affected by 17 beta-E2. beta-e2 14-21 interleukin 6 Homo sapiens 47-51 9092685-0 1997 Tiazofurin-induced autosecretion of IL-6 and hemoglobin production in K562 human leukemia cells. tiazofurin 0-10 interleukin 6 Homo sapiens 36-40 9169347-5 1997 Agonists for protein kinase A (PKA) (forskolin), and protein kinase C (PKC) (phorbol 12-myristate 13-acetate; PMA) also stimulated IL-6/IL-11 production. Colforsin 37-46 interleukin 6 Homo sapiens 131-135 9092685-7 1997 Stimulation of cells with tiazofurin gave a significant increase in IL-6 production. tiazofurin 26-36 interleukin 6 Homo sapiens 68-72 24392463-11 2014 Correlation between serum TNF-a and IL6 levels with healthy donors were statistically significant in 1h (0.004), 2h (0.001), 24h (0.001) and 48h (0.001 and 0.001) postoperatively, respectively. Deuterium 113-115 interleukin 6 Homo sapiens 36-39 9125669-4 1997 IL-1, a physiological activator of PKC, induced a rapid increase in IL-6 messenger RNA (mRNA) levels, which was sustained at 24 h. PMA-induced IL-6 mRNA levels in RASMC were markedly attenuated after downregulation of PKC with PMA and by the selective PKC inhibitor, bisindolylmaleimide. bisindolylmaleimide 267-286 interleukin 6 Homo sapiens 68-72 9125669-4 1997 IL-1, a physiological activator of PKC, induced a rapid increase in IL-6 messenger RNA (mRNA) levels, which was sustained at 24 h. PMA-induced IL-6 mRNA levels in RASMC were markedly attenuated after downregulation of PKC with PMA and by the selective PKC inhibitor, bisindolylmaleimide. bisindolylmaleimide 267-286 interleukin 6 Homo sapiens 143-147 9135506-5 1997 On this basis, a pilot study was performed to evaluate the in vivo effects of the bisphosphonate, pamidronate, on blood levels of IL-6. Diphosphonates 82-96 interleukin 6 Homo sapiens 130-134 9001430-4 1997 In 7-day liquid cultures containing interleukin-3 (IL-3), stem cell factor (SCF) and IL-6, we recovered 3.0-fold more colony-forming cells (CFC) and 1.7- to 1.9-fold more CAFC weeks 2 and 4. cafc 171-175 interleukin 6 Homo sapiens 85-89 8849407-4 1996 Incubation of macrophages with PMMA in this system led to release of prostaglandin E (PGE2), granulocyte macrophage-colony stimulating factor (GM-CSF), and interleukin-6 (IL-6). Polymethyl Methacrylate 31-35 interleukin 6 Homo sapiens 156-169 8849407-4 1996 Incubation of macrophages with PMMA in this system led to release of prostaglandin E (PGE2), granulocyte macrophage-colony stimulating factor (GM-CSF), and interleukin-6 (IL-6). Polymethyl Methacrylate 31-35 interleukin 6 Homo sapiens 171-175 8969952-5 1996 Adrenal steroids were stimulated by IL-6: aldosterone 184 +/- 23, cortisol 198 +/- 19, DHEA 140 +/- 8 and androstenedione 136 +/- 5 (results are means +/- s.e.m. Aldosterone 42-53 interleukin 6 Homo sapiens 36-40 8914271-0 1996 Complete 1H, 15N and 13C assignments, secondary structure, and topology of recombinant human interleukin-6. 15n 13-16 interleukin 6 Homo sapiens 93-106 8914271-1 1996 Essentially complete backbone and side-chain 1H, 15N and 13C resonance assignments for the 185-amino-acid cytokine interleukin-6 (IL-6) are presented. 15n 49-52 interleukin 6 Homo sapiens 115-128 8914271-1 1996 Essentially complete backbone and side-chain 1H, 15N and 13C resonance assignments for the 185-amino-acid cytokine interleukin-6 (IL-6) are presented. 15n 49-52 interleukin 6 Homo sapiens 130-134 24908316-6 2014 In this chapter, we describe a protocol that uses real-time qRT-PCR to quantitatively analyze mRNA levels of IL-8 and IL-6 in BZ-treated ovarian cancer cells. Bortezomib 126-128 interleukin 6 Homo sapiens 118-122 8761470-6 1996 We found that oxidizing agents, such as H2O2 and diamide, as well as alkylating agents, such as iodoacetic acid, abolished, in vitro, the HSF-DNA-binding activity induced by HS in vivo. Diamide 49-56 interleukin 6 Homo sapiens 138-141 8693287-5 1996 Anti-oestrogens, tamoxifen and toremifene, stimulated overall cytokine production on a B-cell line (Ball), whereas on a T-cell line (Molt-4) tamoxifen stimulated IL-1 beta, IL-6 and IFN-gamma production and toremifene inhibited it. Toremifene 31-41 interleukin 6 Homo sapiens 173-177 8941005-0 1996 Medroxyprogesterone acetate treatment reduces serum interleukin-6 levels in patients with metastatic breast carcinoma. Medroxyprogesterone Acetate 0-27 interleukin 6 Homo sapiens 52-65 8941005-1 1996 BACKGROUND: The serum interleukin (IL)-6 concentration was very low in patients with metastatic breast carcinoma who had received oral medroxyprogesterone acetate (MPA) treatment as compared with those who had not. Medroxyprogesterone Acetate 135-162 interleukin 6 Homo sapiens 22-40 8941005-1 1996 BACKGROUND: The serum interleukin (IL)-6 concentration was very low in patients with metastatic breast carcinoma who had received oral medroxyprogesterone acetate (MPA) treatment as compared with those who had not. Medroxyprogesterone Acetate 164-167 interleukin 6 Homo sapiens 22-40 24290899-7 2014 RESULTS: Increasing serum IL-6, IL-8, GRO and neutrophil concentration reduced the risk of CRS progression. 3-cresol 91-94 interleukin 6 Homo sapiens 26-30 8932980-0 1996 The effect of ether lipid 1-O-octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine and its analogues platelet activating factor and carbamyl-platelet activating factor on the biosynthesis of interleukin-6 in human thymic epithelial cells cultivated in vitro. ether lipid 1-o-octadecyl-2-o-methoxy-rac-glycero-3-phosphocholine 14-80 interleukin 6 Homo sapiens 189-202 8654370-9 1996 Interestingly, high affinity hIL-6 variants show strongly enhanced bioactivity on cells expressing gp13O in the presence of shIL-6Ralpha at concentrations similar to those normally found in human sera. gp13o 99-104 interleukin 6 Homo sapiens 29-34 23754245-1 2013 OBJECTIVE: To determine the effect of methotrexate (MTX) on plasma levels of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha and to investigate their associations with clinical and radiographic responses in patients with early rheumatoid arthritis (RA). Methotrexate 38-50 interleukin 6 Homo sapiens 77-95 8818192-0 1996 In vitro modulation of epidermal inflammatory cytokines (IL-1 alpha, IL-6, TNF alpha) by minocycline. Minocycline 89-100 interleukin 6 Homo sapiens 69-73 8699063-4 1996 GBS III-PS, GB-Ag, and LTA each induced IL-6. lipoteichoic acid 23-26 interleukin 6 Homo sapiens 40-44 8699063-5 1996 However, IL-6 release by monocytes was significantly greater after stimulation by GB-Ag than by III-PS or LTA (P < .05). lipoteichoic acid 106-109 interleukin 6 Homo sapiens 9-13 23754245-1 2013 OBJECTIVE: To determine the effect of methotrexate (MTX) on plasma levels of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha and to investigate their associations with clinical and radiographic responses in patients with early rheumatoid arthritis (RA). Methotrexate 52-55 interleukin 6 Homo sapiens 77-95 23754245-8 2013 Serum C-reactive protein (CRP), plasma IL-6, and DAS28 decreased significantly (p <0.001) after MTX treatment, but plasma TNF-alpha did not. Methotrexate 99-102 interleukin 6 Homo sapiens 39-43 8663853-8 1996 CONCLUSIONS: Pretreatment with sheep anti-TNF-alpha Fab suppresses Jarisch-Herxheimer reactions that occur after penicillin treatment for louse-borne relapsing fever, reduces the associated increases in plasma concentrations of interleukin-6 and interleukin-8, and may be useful in other forms of sepsis. Penicillins 113-123 interleukin 6 Homo sapiens 228-241 23754245-11 2013 CONCLUSION: In this early RA cohort, we demonstrated a significant (p <0.001) reduction of plasma IL-6, but not TNF-alpha, during MTX treatment. Methotrexate 133-136 interleukin 6 Homo sapiens 101-105 8849255-6 1996 In contrast to the effect on T cells, addition of minocycline to lipopolysaccharide-stimulated monocytes led to a dose-dependent increase in TNF-alpha and IL-6 production which was paralleled by an enhancement of TNF-alpha mRNA synthesis. Minocycline 50-61 interleukin 6 Homo sapiens 155-159 24212838-9 2013 The fixed combinations induced an increase in IL-6 expression in the travoprost/timolol group, in which there was also an increase in HLA-DR expression. Travoprost 69-79 interleukin 6 Homo sapiens 46-50 8777865-0 1996 Soluble interleukin-2-receptor and interleukin-6 changes during low-dose methotrexate treatment in rheumatoid arthritis. Methotrexate 73-85 interleukin 6 Homo sapiens 35-48 8834013-6 1996 Decreases in circulating IL-6, soluble IL-2 (sIL-2R), and TNF receptors and in synovial fluid IL-1 levels have been reported with methotrexate. Methotrexate 130-142 interleukin 6 Homo sapiens 25-29 23831394-5 2013 Troglitazone (10 muM) and L-165,041 (1 muM) significantly inhibited high glucose (25mM)-induced interleukin-6 and TNF-alpha production, RAGE expression and NF-kappaB translocation in HEK cells. Troglitazone 0-12 interleukin 6 Homo sapiens 96-109 8523572-6 1996 IL-6 induction by EBV was inhibited with the PKC-specific inhibitor bisindolylmaleimide or the protein tyrosine kinase inhibitors methyl 2,5-dihydroxycinnamate and herbimycin A, indicating that the induction of IL-6 following CD21 cross-linking is mediated through PKC- and protein tyrosine kinase-dependent pathways. bisindolylmaleimide 68-87 interleukin 6 Homo sapiens 0-4 8536717-13 1995 The plasma clearance of soluble 125I-labeled IL-6 receptor in the absence and presence of IL-6 was studied in rats as a model system. Iodine-125 32-36 interleukin 6 Homo sapiens 45-49 7490793-1 1995 This study aimed to assess the possibility of a direct effect of betel-nut alkaloids arecoline and arecaidine on cell proliferation and interleukin-6 (IL-6) production by cultured fibroblasts from human normal gingiva, buccal mucosa and oral submucous fibrosis (OSF) buccal mucosa in vitro. Alkaloids 75-84 interleukin 6 Homo sapiens 136-149 8861742-8 1996 Serum levels of IL-6 decreased in the minocycline-treated group only and this decrease was positively correlated with the decrease in CRP levels. Minocycline 38-49 interleukin 6 Homo sapiens 16-20 8861742-12 1996 The anti-inflammatory effect of minocycline in RA patients may be due to the reduction in the synthesis of IL-6 and rheumatoid factor. Minocycline 32-43 interleukin 6 Homo sapiens 107-133 11859379-8 1996 This inhibition of IL-6 expression by NDGA and indomethacin was dose responsive and also reversible with the addition of exogenous prostaglandin E(2) (PGE(2)) or leukotriene B(4) (LTB(4)). Masoprocol 38-42 interleukin 6 Homo sapiens 19-23 11859379-8 1996 This inhibition of IL-6 expression by NDGA and indomethacin was dose responsive and also reversible with the addition of exogenous prostaglandin E(2) (PGE(2)) or leukotriene B(4) (LTB(4)). Prostaglandins E 131-146 interleukin 6 Homo sapiens 19-23 11859379-8 1996 This inhibition of IL-6 expression by NDGA and indomethacin was dose responsive and also reversible with the addition of exogenous prostaglandin E(2) (PGE(2)) or leukotriene B(4) (LTB(4)). Prostaglandins E 151-154 interleukin 6 Homo sapiens 19-23 23475935-9 2013 NTBI levels were higher after transfusion (p<0.01) returning to pretransfusion levels by 24 h. Post-transfusion NTBI level correlated with the age of transfused blood (p<0.001) and was positively correlated with plasma MDA (p=0.01) but not IL-1beta, IL-6, IL8 or TNFalpha. ntbi 0-4 interleukin 6 Homo sapiens 256-260 11859379-9 1996 Although IL-1-induced IL-6 expression was only affected when both prostaglandin and leukotriene biosynthesis were inhibited, elevated levels of PGE(2) but not leukotriene B(4), C(4), D(4), or E(4) were observed in the culture medium of IL-1-treated chondrocytes. Prostaglandins E 144-147 interleukin 6 Homo sapiens 22-26 8614289-3 1996 Incubation of cultured meningioma cells for 4-6 days with cholera toxin and theophylline, both of which increase intracellular cAMP levels, markedly stimulated IL6 secretion and inhibited cell growth rate. Theophylline 76-88 interleukin 6 Homo sapiens 160-163 7592638-3 1995 Inspection of the promoter region of the fibrinogen gamma gene revealed three hexanucleotide clusters of CTGGGA that are recognized as class II IL-6 responsive elements. hexanucleotide 78-92 interleukin 6 Homo sapiens 144-148 23475935-9 2013 NTBI levels were higher after transfusion (p<0.01) returning to pretransfusion levels by 24 h. Post-transfusion NTBI level correlated with the age of transfused blood (p<0.001) and was positively correlated with plasma MDA (p=0.01) but not IL-1beta, IL-6, IL8 or TNFalpha. ntbi 115-119 interleukin 6 Homo sapiens 256-260 23977231-6 2013 Inhibition studies using antisense RNA and the pharmacological agent BAY-117082 confirmed the involvement of NF-kappaB in IL-6, IL-8, and IL-1beta secretion. 3-(4-methylphenylsulfonyl)-2-propenenitrile 69-79 interleukin 6 Homo sapiens 122-126 8845742-5 1995 In the astroglioma cell line, the stimulated release of tumor necrosis factor-alpha, interleukin-6 and interleukin-8 was diminished by ammonium acetate. ammonium acetate 135-151 interleukin 6 Homo sapiens 85-98 7642293-6 1995 Secretion of IL-6 and IL-8 into the culture medium was detected at 6 and 3 h, respectively, after exposure to P-LPS (10 micrograms/ml). p-lps 110-115 interleukin 6 Homo sapiens 13-17 8550818-4 1995 The synthetic ceramides C2- and C6-ceramide as well as the enzyme sphingomyelinase were able to induce IL-6 gene transcription and protein synthesis in a dose-dependent manner with maximal IL-6 mRNA levels being reached after 4 h of ceramide treatment. c2- and c6-ceramide 24-43 interleukin 6 Homo sapiens 103-107 8550818-4 1995 The synthetic ceramides C2- and C6-ceramide as well as the enzyme sphingomyelinase were able to induce IL-6 gene transcription and protein synthesis in a dose-dependent manner with maximal IL-6 mRNA levels being reached after 4 h of ceramide treatment. c2- and c6-ceramide 24-43 interleukin 6 Homo sapiens 189-193 7595543-3 1995 Complete to nearly complete inhibition of interleukin-1 beta-induced interleukin-6 production was observed with the flavonoids genistein and quercetin, the bisindole alkaloids staurosporine and K-252a, or the tyrphostin AG879. Flavonoids 116-126 interleukin 6 Homo sapiens 69-82 7595543-3 1995 Complete to nearly complete inhibition of interleukin-1 beta-induced interleukin-6 production was observed with the flavonoids genistein and quercetin, the bisindole alkaloids staurosporine and K-252a, or the tyrphostin AG879. Quercetin 141-150 interleukin 6 Homo sapiens 69-82 7595543-3 1995 Complete to nearly complete inhibition of interleukin-1 beta-induced interleukin-6 production was observed with the flavonoids genistein and quercetin, the bisindole alkaloids staurosporine and K-252a, or the tyrphostin AG879. staurosporine aglycone 194-200 interleukin 6 Homo sapiens 69-82 23514733-6 2013 LY2189102 also reduced postprandial glycemia, and inflammatory biomarkers, including hs-CRP and IL-6. LY2189102 0-9 interleukin 6 Homo sapiens 96-100 7592665-3 1995 Salicylate induces the DNA binding state of the human heat shock transcription factor (HSF), but this is insufficient to elevate heat shock gene expression. Salicylates 0-10 interleukin 6 Homo sapiens 54-85 7551660-5 1995 Treatment with MTX alone (n = 12) or combined with SASP (n = 14), resulted in significant reductions of circulating IL-6 and sIL-2R but did not alter IL-1 beta, TNF alpha or IL-1RA concentrations. Methotrexate 15-18 interleukin 6 Homo sapiens 116-120 7551660-8 1995 In conclusion, therapy with MTX alone or with SASP modulates IL-6 and sIL-2R concentrations in RA. Methotrexate 28-31 interleukin 6 Homo sapiens 61-65 7592665-3 1995 Salicylate induces the DNA binding state of the human heat shock transcription factor (HSF), but this is insufficient to elevate heat shock gene expression. Salicylates 0-10 interleukin 6 Homo sapiens 87-90 7744875-4 1995 In good agreement with our structural model, substitutions at Asn-230, His-280, and Asp-281 selectively impaired the capability of shIL-6R alpha to associate with hgp130 both in vitro and on the cell surface, without affecting its affinity for hIL-6. Aspartic Acid 84-87 interleukin 6 Homo sapiens 132-137 23791833-7 2013 Furthermore, pharmacological inhibition of NF-kappaB activation by PDTC and BAY 11-7082, markedly suppressed the IL-6-mediated PON1 expression. 3-(4-methylphenylsulfonyl)-2-propenenitrile 76-87 interleukin 6 Homo sapiens 113-117 7861762-7 1995 At a concentration of 1000 ng/ml, IL-6 increased neutrophil phagocytosis of opsonized bacteria (826 +/- 255 x 10(3) MESF vs 552 +/- 103 MESF, P < 0.05) and also increased neutrophil superoxide anion generation (18.41 +/- 1.86 vs 12.6 nmol O2-/10(6) PMN/10 min, P < 0.05). mesf 116-120 interleukin 6 Homo sapiens 34-38 8576941-6 1995 Amrinone at 26 mumol/l and NKH477 at 10 nmol/l also had a less marked inhibitory effect against the production of IL-6. Colforsin 27-33 interleukin 6 Homo sapiens 114-118 8576944-3 1995 Here we demonstrate that the four Ca(2+)-channel blockers, Amlodipine, Felodipine, Isradipine and Manidipine, at nanomolar concentrations, activate the transcription of the genes encoding IL-6 and IL-8 in primary human VSMC and fibroblasts. Isradipine 83-93 interleukin 6 Homo sapiens 188-192 7861762-10 1995 Combining IL-6 with TNF-alpha at doses of 100 ng/ml and 100 U/ml, respectively, neutrophil phagocytosis (221 +/- 455 MESF vs 552 +/- 103 MESF) and superoxide generation (23.18 +/- 1.86 vs 12.6 nmol O2-/10(6) PMN/10 min) were significantly (P < 0.05) increased above control by an amount similar to that seen with 1000 U/ml TNF-alpha alone. mesf 117-121 interleukin 6 Homo sapiens 10-14 7861762-10 1995 Combining IL-6 with TNF-alpha at doses of 100 ng/ml and 100 U/ml, respectively, neutrophil phagocytosis (221 +/- 455 MESF vs 552 +/- 103 MESF) and superoxide generation (23.18 +/- 1.86 vs 12.6 nmol O2-/10(6) PMN/10 min) were significantly (P < 0.05) increased above control by an amount similar to that seen with 1000 U/ml TNF-alpha alone. mesf 137-141 interleukin 6 Homo sapiens 10-14 23201587-5 2013 Accordingly, F2-IsoP concentrations were positively correlated with the ratio of IL-6/IL-10 (p<0.01). F2-Isoprostanes 13-20 interleukin 6 Homo sapiens 81-85 7664026-0 1995 Circulating interleukin 10 and interleukin-6 serum levels in rheumatoid arthritis patients treated with methotrexate or gold salts: preliminary report. Methotrexate 104-116 interleukin 6 Homo sapiens 31-44 7788003-0 1995 Serum levels of interleukin 6 and tumor necrosis factor-alpha in hyperthyroid patients before and after propylthiouracil treatment. Propylthiouracil 104-120 interleukin 6 Homo sapiens 16-61 7572320-0 1995 Interleukin-6 and the acute phase response during treatment of patients with Paget"s disease with the nitrogen-containing bisphosphonate dimethylaminohydroxypropylidene bisphosphonate. Diphosphonates 122-136 interleukin 6 Homo sapiens 0-13 23364255-9 2013 Plasma levels of hs-CRP, IL-6, and MCP-1 increased significantly after PCI in both the rosuvastatin and control groups; however, the postprocedural elevations in hs-CRP and IL-6 levels were significantly lower in the rosuvastatin group than the control group. Rosuvastatin Calcium 87-99 interleukin 6 Homo sapiens 173-177 7572320-0 1995 Interleukin-6 and the acute phase response during treatment of patients with Paget"s disease with the nitrogen-containing bisphosphonate dimethylaminohydroxypropylidene bisphosphonate. dimethylaminohydroxypropylidene bisphosphonate 137-183 interleukin 6 Homo sapiens 0-13 7611579-0 1995 [Increase in interleukin-6 plasma concentrations following hypotensive anesthesia with sodium nitroprusside]. Nitroprusside 87-107 interleukin 6 Homo sapiens 13-26 7664026-1 1995 In order to evaluate the relationship between serum concentrations of interleukin-10 (IL-10), IL-6, and acute phase proteins in rheumatoid arthritis (RA) patients treated with methotrexate (MTX) or intramuscular gold (IMG) we determined IL-10, IL-6, C-reactive protein (CRP), alpha-1-acid glycoprotein (AGP) and alpha-1-antichymotrypsin (ACT) in the sera of 35 RA patients. Methotrexate 190-193 interleukin 6 Homo sapiens 94-98 7664026-7 1995 Patients treated with MTX or IMG presented an increased level of IL-10 and decreased amounts of IL-6, as compared to those treated with NSAID only. Methotrexate 22-25 interleukin 6 Homo sapiens 96-100 7962338-5 1994 RAI was also followed by a significant (P < 0.0001) increase in IL-6 from 52 fmol/L (range, < 25 to 84) to 189 fmol/L (range, 119-1417 fmol/L); the increase after RAI was lower than that after PIEI (P < 0.05), and the peak value was attained later (after 24 h). Insulin, Short-Acting 169-172 interleukin 6 Homo sapiens 67-71 7529912-4 1994 Agents which mimicked (dibutyryl cAMP) or stimulated (isoproterenol and forskolin) cAMP formation were found to induce IL-6 release and their effects could be potentiated by 3-isobutyl-1-methylxanthine (IBMX), a phosphodiesterase inhibitor. Colforsin 72-81 interleukin 6 Homo sapiens 119-123 23364255-10 2013 CONCLUSIONS: A single, high dose (20 mg) of rosuvastatin prior to PCI reduces postprocedural myocardial injury in patients with ACS, with a concomitant attenuation of the postprocedural increase in hs-CRP and IL-6 levels. Rosuvastatin Calcium 44-56 interleukin 6 Homo sapiens 209-213 9816008-10 1995 These results show that multilamellar vesicle muramyl tripeptide phosphatidylethanolamine administration activates monocyte cytotoxicity and cytokine production (TNF-alpha, IL-6). tripeptide K-26 54-64 interleukin 6 Homo sapiens 173-177 23471810-0 2013 Effect of flavonoids on circulating levels of TNF-alpha and IL-6 in humans: a systematic review and meta-analysis. Flavonoids 10-20 interleukin 6 Homo sapiens 60-64 7676273-5 1995 The close relationship between sequential changes in the levels of tumour necrosis factor (TNF), Interleukin 1 and 6 (IL-1 and IL-6) in the serum, to the clinical progression of the disease from DF to DHF/DSS and then to full recovery implicates a pathogenetic role for the inflammatory cytokines. dhf 201-204 interleukin 6 Homo sapiens 127-131 7969016-7 1994 However, with Polymethylmethacrylate (PMMA) membrane, there found production of IL-6, IL-1 alpha, IL-1 beta and TNF-alpha in extremely small quantities. Polymethyl Methacrylate 14-36 interleukin 6 Homo sapiens 80-84 7969016-7 1994 However, with Polymethylmethacrylate (PMMA) membrane, there found production of IL-6, IL-1 alpha, IL-1 beta and TNF-alpha in extremely small quantities. Polymethyl Methacrylate 38-42 interleukin 6 Homo sapiens 80-84 8034686-2 1994 IL-6 expression is induced in young human diploid fibroblasts (HDF) in response to a number of agents including fetal bovine serum, 12-O-tetradecanoylphorbol-13-acetate, double-stranded RNA, and forskolin. Colforsin 195-204 interleukin 6 Homo sapiens 0-4 23396138-1 2013 Co-exposure to environmental polycyclic aromatic hydrocarbons (PAHs) and interleukin (IL)-1beta induces expression of the tumor-promoting cytokine IL-6 in cancer cells. Polycyclic Aromatic Hydrocarbons 29-61 interleukin 6 Homo sapiens 147-151 23396138-1 2013 Co-exposure to environmental polycyclic aromatic hydrocarbons (PAHs) and interleukin (IL)-1beta induces expression of the tumor-promoting cytokine IL-6 in cancer cells. Polycyclic Aromatic Hydrocarbons 63-67 interleukin 6 Homo sapiens 147-151 8307982-0 1994 G(Anh)MTetra, a natural bacterial cell wall breakdown product, induces interleukin-1 beta and interleukin-6 expression in human monocytes. mtetra 6-12 interleukin 6 Homo sapiens 94-107 7897158-3 1995 Tenidap sodium has been demonstrated in in vitro studies to inhibit cyclooxygenase, lipoxygenase, and cytokine production (interleukin-1, interleukin-6, tumor necrosis factor-alpha). tenidap 0-14 interleukin 6 Homo sapiens 138-180 23396138-3 2013 Co-exposure to the prototypical PAH benzanthracene (BZA) and TNF-alpha was found to markedly induce mRNA expression and secretion of IL-6 in human breast cancer cells MCF-7, whereas exposure to either BZA or TNF-alpha alone was without significant effect. Polycyclic Aromatic Hydrocarbons 32-35 interleukin 6 Homo sapiens 133-137 8307982-5 1994 G(Anh)MTetra was found to strongly induce interleukin (IL)-1 beta and IL-6 mRNA expression after 2 h and IL-1 beta and IL-6 protein secretion after 48 h of activation. mtetra 6-12 interleukin 6 Homo sapiens 70-74 8307982-7 1994 Experiments using inhibitors of protein kinase C, protein kinase A, and tyrosine kinase-dependent pathways revealed that G(Anh)MTetra-induced IL-1 beta and IL-6 mRNA expression involves activation of an H7-inhibitable pathway. mtetra 127-133 interleukin 6 Homo sapiens 156-160 23396138-5 2013 BZA/TNF-alpha-mediated IL-6 induction in MCF-7 cells was counteracted by silencing aryl hydrocarbon receptor (AhR), known to mediates most of PAH effects. Polycyclic Aromatic Hydrocarbons 142-145 interleukin 6 Homo sapiens 23-27 8301142-3 1994 To further understand the biology of retinoids and IL-6 we determined whether all-trans-retinoic acid (RA) and other retinoids regulate lung fibroblast IL-6 production. Retinoids 117-126 interleukin 6 Homo sapiens 152-156 7530507-4 1995 We have analyzed the prognostic significance of serum immunoreactive IL-6, as measured by a sensitive immunosorbent assay, in 210 patients with newly diagnosed MM subsequently treated with intermittent melphalan and prednisone. Melphalan 202-211 interleukin 6 Homo sapiens 69-73 7738942-0 1995 Interleukin 6 (IL-6) and soluble IL-2 receptor levels in patients with rheumatoid arthritis treated with low dose oral methotrexate. Methotrexate 119-131 interleukin 6 Homo sapiens 0-13 8301142-9 1994 13-cis-retinoic acid, retinol, retinaldehyde, all-trans etretin, Ro 13-6298, and 9-cis retinoic acid also inhibited IL-1-induced IL-6 production. Isotretinoin 0-20 interleukin 6 Homo sapiens 129-133 8301142-9 1994 13-cis-retinoic acid, retinol, retinaldehyde, all-trans etretin, Ro 13-6298, and 9-cis retinoic acid also inhibited IL-1-induced IL-6 production. 2-octenal 50-55 interleukin 6 Homo sapiens 129-133 8301142-9 1994 13-cis-retinoic acid, retinol, retinaldehyde, all-trans etretin, Ro 13-6298, and 9-cis retinoic acid also inhibited IL-1-induced IL-6 production. Alitretinoin 81-100 interleukin 6 Homo sapiens 129-133 7738942-1 1995 OBJECTIVE: To investigate the effect of oral methotrexate (MTX) on circulating levels of interleukin 6 (IL-6) and soluble IL-2 receptor (sIL-2R) in patients with rheumatoid arthritis (RA). Methotrexate 45-57 interleukin 6 Homo sapiens 89-102 23488631-5 2013 A significant, more than 50% mean inhibition of PMA/I-induced IL-6 and IL-8 release was demonstrated for the volatile compounds 1,8-cineole, borneol, camphor, and thujone, but not for the nonvolatile rosmarinic acid when applied in concentrations representative of sage infusion. Eucalyptol 128-139 interleukin 6 Homo sapiens 62-66 7738942-1 1995 OBJECTIVE: To investigate the effect of oral methotrexate (MTX) on circulating levels of interleukin 6 (IL-6) and soluble IL-2 receptor (sIL-2R) in patients with rheumatoid arthritis (RA). Methotrexate 45-57 interleukin 6 Homo sapiens 104-108 7738942-1 1995 OBJECTIVE: To investigate the effect of oral methotrexate (MTX) on circulating levels of interleukin 6 (IL-6) and soluble IL-2 receptor (sIL-2R) in patients with rheumatoid arthritis (RA). Methotrexate 59-62 interleukin 6 Homo sapiens 89-102 7738942-1 1995 OBJECTIVE: To investigate the effect of oral methotrexate (MTX) on circulating levels of interleukin 6 (IL-6) and soluble IL-2 receptor (sIL-2R) in patients with rheumatoid arthritis (RA). Methotrexate 59-62 interleukin 6 Homo sapiens 104-108 23643167-3 2013 The effects of LPS and an NF-kappaB inhibitor, BAY11-7082 on the secretion of TNF-alpha and IL-6 were also observed. 3-(4-methylphenylsulfonyl)-2-propenenitrile 47-57 interleukin 6 Homo sapiens 92-96 7738942-3 1995 RESULTS: MTX significantly reduced IL-6 and sIL-2R after 12 weeks of therapy, and although the levels remained low at 24 weeks of therapy, the reduction was not significant. Methotrexate 9-12 interleukin 6 Homo sapiens 35-39 7869761-6 1995 Using a 3H-thymidine incorporation assay, DNA synthesis of leukemic blasts could be stimulated by IL-3, IL-6 and G-CSF in vitro. 3h-thymidine 8-20 interleukin 6 Homo sapiens 104-108 7810656-5 1994 Hepatocytes cultured for 20 h in media containing IL-6 exhibited a dose-dependent noncompetitive inhibition of [3H]taurocholate uptake, which was maximal at an IL-6 dose of 100 U/ml. Taurocholic Acid 115-127 interleukin 6 Homo sapiens 50-54 23643167-6 2013 BAY11-7082 inhibited the secretion of TNF-alpha and IL-6 in THP-1 stimulated by LPS and rhGH. 3-(4-methylphenylsulfonyl)-2-propenenitrile 0-10 interleukin 6 Homo sapiens 52-56 7810656-5 1994 Hepatocytes cultured for 20 h in media containing IL-6 exhibited a dose-dependent noncompetitive inhibition of [3H]taurocholate uptake, which was maximal at an IL-6 dose of 100 U/ml. Taurocholic Acid 115-127 interleukin 6 Homo sapiens 160-164 7810656-11 1994 The inhibition of Na(+)-K(+)-ATPase activity induced by IL-6 provides a putative mechanism for the observed inhibition of sodium-dependent taurocholate uptake. Taurocholic Acid 139-151 interleukin 6 Homo sapiens 56-60 23470916-2 2013 Several studies indicated that change in the guanine bases to cytosine at position -174 affects the transcription of the IL6 gene, and finally IL6 production level. Guanine 45-52 interleukin 6 Homo sapiens 121-124 23470916-2 2013 Several studies indicated that change in the guanine bases to cytosine at position -174 affects the transcription of the IL6 gene, and finally IL6 production level. Guanine 45-52 interleukin 6 Homo sapiens 143-146 23300158-4 2013 RESULTS: Ribavirin decreased the virus load and dose-dependently inhibited the accumulation of RANTES messenger RNA in Andes-virus (ANDV)-infected human endothelial cells, but failed to suppress TNF-alpha-induced activation of RANTES and interleukin-6 in ANDV-inoculated cultures. Ribavirin 9-18 interleukin 6 Homo sapiens 238-251 7538847-10 1994 For human IL-6, it would appear that interactions between residues Ala-180, Leu-181, and Met-184 and residues in the N-terminal region may be critical for maintaining the structure of the molecule; replacement of these residues with the corresponding 3 residues in mouse IL-6 correlated with a significant loss of alpha-helical content and a 200-fold reduction in activity in the mouse bioassay. Leucine 76-79 interleukin 6 Homo sapiens 10-14 7962338-5 1994 RAI was also followed by a significant (P < 0.0001) increase in IL-6 from 52 fmol/L (range, < 25 to 84) to 189 fmol/L (range, 119-1417 fmol/L); the increase after RAI was lower than that after PIEI (P < 0.05), and the peak value was attained later (after 24 h). Insulin, Short-Acting 0-3 interleukin 6 Homo sapiens 67-71 23218935-5 2013 The addition of ketorolac to bupivacaine significantly decreased IL-6 (P = .012) and IL-10 (P = .005) compared to plain bupivacaine. Bupivacaine 29-40 interleukin 6 Homo sapiens 65-69 8195120-5 1994 By Northern blotting analysis, the increased expression of IL1 alpha, IL1 beta, and IL6 genes was shown to occur at 30 min of Mit C and MMS treatment and to decline after 8 h. Similarly, EMS up-regulated the expression of IL1 beta and IL6 genes. Methyl Methanesulfonate 136-139 interleukin 6 Homo sapiens 84-87 22703874-2 2012 Both atorvastatin calcium (lipitor) as well as flavonoid rich fruit such as tart cherry demonstrate potent anti-inflammatory effects on IL-6 secretion. Flavonoids 47-56 interleukin 6 Homo sapiens 136-140 22703874-4 2012 Results showed that LPS-induced adipose stem cell secretion of IL-6 reduced with the addition of tart cherry extract, a mixture of tart cherry anthocyanins, and pure tart cherry cyanidin-3-O-glucoside (C3G) in a dose-dependent manner. tart cherry 97-108 interleukin 6 Homo sapiens 63-67 8162613-2 1994 Total melanoma gangliosides in micelles inhibited proliferation of peripheral blood mononuclear cells stimulated by various mitogens, modulated lymphocyte surface molecules CD2, CD3, CD4, CD5 and CD8 and inhibited the production of interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha) and IL-6 by stimulated adherent cells. Gangliosides 15-27 interleukin 6 Homo sapiens 308-312 22532637-8 2012 CONCLUSION: Serum IL-6 concentration is greater in RA than in UA. ulmoside A 62-64 interleukin 6 Homo sapiens 18-22 8168335-9 1994 Both phorbol myristate acetate and N-formyl-methionyl-leucylphenylalanine induced further release of nitric oxide, which was increased by preincubation with lipopolysaccharide, interleukin-6 and interferon-gamma. N-Formylmethionine Leucyl-Phenylalanine 35-73 interleukin 6 Homo sapiens 177-190 8288320-0 1993 Long-term administration of 13-cis retinoic acid in common variable immunodeficiency: circulating interleukin-6 levels, B-cell surface molecule display, and in vitro and in vivo B-cell antibody production. Isotretinoin 28-48 interleukin 6 Homo sapiens 98-111 22561332-6 2012 Further studies revealed that WFA suppressed the production of interleukin 6, tumor necrosis factor-alpha (TNF-alpha) and activation of nuclear factor-kappaB (NF-kappaB) by HMGB1. withaferin A 30-33 interleukin 6 Homo sapiens 63-105 8240983-1 1993 Previous studies have revealed that human breast fibroblasts secrete the cytokine, interleukin-6 (IL-6) which stimulates the ability of MCF-7 human breast carcinoma cells to convert estrone (E1) to the biologically more active 17 beta-estradiol (E2). Estrone 182-189 interleukin 6 Homo sapiens 83-96 8240983-1 1993 Previous studies have revealed that human breast fibroblasts secrete the cytokine, interleukin-6 (IL-6) which stimulates the ability of MCF-7 human breast carcinoma cells to convert estrone (E1) to the biologically more active 17 beta-estradiol (E2). Estrone 182-189 interleukin 6 Homo sapiens 98-102 8393800-4 1993 This induction of IL-6 production could be achieved by reagents known to increase intracellular levels of cAMP, such as forskolin, prostaglandin E or pentoxifylline. Colforsin 120-129 interleukin 6 Homo sapiens 18-22 8393800-4 1993 This induction of IL-6 production could be achieved by reagents known to increase intracellular levels of cAMP, such as forskolin, prostaglandin E or pentoxifylline. Prostaglandins E 131-146 interleukin 6 Homo sapiens 18-22 21932058-2 2012 The study was tested in a fecal peritonitis-induced septic shock model, we observed that levosimendan combined with arginine vasopressin supplemented with norepinephrine therapy resulted in lower mean pulmonary artery pressure, lactate concentrations, arterial total nitrate/nitrite, and high-mobility group box 1 levels; decreased lung wet/dry ratio, and pulmonary levels of interleukin-6, total histological scores, and improved pulmonary gas exchange when compared with norepinephrine group. Simendan 89-101 interleukin 6 Homo sapiens 376-389 7685108-5 1993 Go 6976 is a nonglycosidic indolocarbazole found to potently inhibit HIV-1 induction by Bryostatin 1, tumor necrosis factor alpha, and interleukin 6. Indolocarbazole 27-42 interleukin 6 Homo sapiens 135-148 8318672-7 1993 Autologous thymocytes stimulated normal and MG TEC IL-6 production in a time- and dose- dependent way, and with a higher magnitude in MG TEC compared to controls. Turpentine 47-50 interleukin 6 Homo sapiens 51-55 22573369-6 2012 Overall, several flavonoids from P. corylifolia might be useful remedies for treating inflammatory diseases by inhibiting IL-6-induced STAT3 activation and phosphorylation. Flavonoids 17-27 interleukin 6 Homo sapiens 122-126 7682247-2 1993 The binding of heat shock factor (HSF) in response to heat and varying concentrations of bleomycin in the four cell lines was examined using a gel shift assay and a synthetic heat shock element (HSE). Bleomycin 89-98 interleukin 6 Homo sapiens 15-32 7682247-2 1993 The binding of heat shock factor (HSF) in response to heat and varying concentrations of bleomycin in the four cell lines was examined using a gel shift assay and a synthetic heat shock element (HSE). Bleomycin 89-98 interleukin 6 Homo sapiens 34-37 7682247-3 1993 Heat (45 degrees C, 10 min) and exposure to 1 micrograms/ml bleomycin for 1 h at 37 degrees C induced similar levels of HSF binding in all four cell lines. Bleomycin 60-69 interleukin 6 Homo sapiens 120-123 7682247-4 1993 We also examined if bleomycin dose and the length of recovery from bleomycin treatment affected the induction of HSF binding. Bleomycin 20-29 interleukin 6 Homo sapiens 113-116 7682247-4 1993 We also examined if bleomycin dose and the length of recovery from bleomycin treatment affected the induction of HSF binding. Bleomycin 67-76 interleukin 6 Homo sapiens 113-116 22306153-5 2012 RESULTS: Minocycline significantly reduced the inflammatory response in LPS-challenged monocytes, decreasing LPS-induced transcription of pro-inflammatory tumor-necrosis factor alpha (TNF-alpha), interleukin-1 beta, interleukin-6 (IL-6) and cyclooxygenase-2 (COX-2), and the LPS-stimulated TNF-alpha, IL-6 and PGE(2) release. Minocycline 9-20 interleukin 6 Homo sapiens 216-229 7682247-5 1993 The level of activated HSF binding to HSE was higher in cells treated with low doses (1 ng/ml) of bleomycin than in cells treated with 1 or 25 micrograms/ml bleomycin. Bleomycin 98-107 interleukin 6 Homo sapiens 23-26 7682247-6 1993 The amount of activated HSF was directly proportional to the time elapsed since bleomycin treatment. Bleomycin 80-89 interleukin 6 Homo sapiens 24-27 7682247-7 1993 Our results therefore indicate no difference between CHO and its bleomycin-sensitive derivatives in the ability to initiate the heat shock response as determined by the production of activated HSF in response to either heat or bleomycin. Bleomycin 227-236 interleukin 6 Homo sapiens 193-196 22306153-5 2012 RESULTS: Minocycline significantly reduced the inflammatory response in LPS-challenged monocytes, decreasing LPS-induced transcription of pro-inflammatory tumor-necrosis factor alpha (TNF-alpha), interleukin-1 beta, interleukin-6 (IL-6) and cyclooxygenase-2 (COX-2), and the LPS-stimulated TNF-alpha, IL-6 and PGE(2) release. Minocycline 9-20 interleukin 6 Homo sapiens 231-235 8218951-3 1993 Since CPA-containing LTBMC-CM always contains a substantial level of IL-6, CPA was thought to be similar to IL-6. colony promoting activity 6-9 interleukin 6 Homo sapiens 69-73 22306153-5 2012 RESULTS: Minocycline significantly reduced the inflammatory response in LPS-challenged monocytes, decreasing LPS-induced transcription of pro-inflammatory tumor-necrosis factor alpha (TNF-alpha), interleukin-1 beta, interleukin-6 (IL-6) and cyclooxygenase-2 (COX-2), and the LPS-stimulated TNF-alpha, IL-6 and PGE(2) release. Minocycline 9-20 interleukin 6 Homo sapiens 301-305 21416238-7 2012 IL-6 in the plasma increased in the SRP group, but slightly decreased in the SRP+minocycline group (0.469 pg/ml, p = 0.172). Minocycline 81-92 interleukin 6 Homo sapiens 0-4 1508207-2 1992 Previous studies revealed that, as during heat shock, transcriptional induction of hsp70 in hemin-treated cells is mediated by activation of heat shock transcription factor (HSF), which binds to the heat shock element (HSE). Hemin 92-97 interleukin 6 Homo sapiens 141-172 1508207-2 1992 Previous studies revealed that, as during heat shock, transcriptional induction of hsp70 in hemin-treated cells is mediated by activation of heat shock transcription factor (HSF), which binds to the heat shock element (HSE). Hemin 92-97 interleukin 6 Homo sapiens 174-177 1508207-5 1992 Both hemin and heat shock treatments resulted in equivalent levels of HSF-HSE complexes as analyzed in vitro by gel mobility shift assay, yet transcription of the hsp70 gene was stimulated much less by hemin-induced HSF than by heat shock-induced HSF. Hemin 5-10 interleukin 6 Homo sapiens 70-73 22313388-10 2012 Overall, our results strongly suggest that EGCG induces Fas/CD95-mediated apoptosis through inhibiting constitutive and IL-6-induced JAK/STAT3 signaling. ammonium ferrous sulfate 56-59 interleukin 6 Homo sapiens 120-124 1508207-5 1992 Both hemin and heat shock treatments resulted in equivalent levels of HSF-HSE complexes as analyzed in vitro by gel mobility shift assay, yet transcription of the hsp70 gene was stimulated much less by hemin-induced HSF than by heat shock-induced HSF. Hemin 202-207 interleukin 6 Homo sapiens 216-219 1508207-5 1992 Both hemin and heat shock treatments resulted in equivalent levels of HSF-HSE complexes as analyzed in vitro by gel mobility shift assay, yet transcription of the hsp70 gene was stimulated much less by hemin-induced HSF than by heat shock-induced HSF. Hemin 202-207 interleukin 6 Homo sapiens 216-219 1508207-6 1992 Genomic footprinting experiments revealed that hemin-induced HSF and heat shock-induced HSF, HSF2, and HSF1, respectively, occupy the HSE of the human hsp70 promoter in a similar yet not identical manner. Hemin 47-52 interleukin 6 Homo sapiens 61-64 21885397-10 2012 Carbachol stimulated release of LTB(4) from lung macrophages (buffer 222.3 +- 75.1 versus carbachol 1,118 +- 622.4 pg mL(-1); n = 15, p<0.05) but not IL-6 or IL-8. Carbachol 0-9 interleukin 6 Homo sapiens 155-159 1508207-6 1992 Genomic footprinting experiments revealed that hemin-induced HSF and heat shock-induced HSF, HSF2, and HSF1, respectively, occupy the HSE of the human hsp70 promoter in a similar yet not identical manner. Hemin 47-52 interleukin 6 Homo sapiens 88-91 1596568-2 1992 Exposure to IL-3, IL-7, IL-1, and IL-6 resulted in a mean 2.8-, 1.5-, 1.4-, and 1.6-fold stimulation of 3H-thymidine (3H-TdR) incorporation, respectively. 3h-thymidine 104-116 interleukin 6 Homo sapiens 34-38 1632677-4 1992 Regenerating liver KC 48 to 120 hours after partial hepatectomy responded to endotoxin stimulation with a significantly greater (p less than 0.05) production of IL-6 in standard RPMI-1640. rpmi-1640 178-187 interleukin 6 Homo sapiens 161-165 22192353-0 2012 Peroxisome proliferating activating receptor gamma-independent attenuation of interleukin 6 and interleukin 8 secretion from primary endometrial stromal cells by thiazolidinediones. Thiazolidinediones 162-180 interleukin 6 Homo sapiens 78-91 1632677-6 1992 Production of IL-6 by regenerating liver KC was further increased (p less than 0.05) by placing these same KC in 10 microM L-arginine RPMI-1640 tissue culture media. rpmi-1640 134-143 interleukin 6 Homo sapiens 14-18 1569394-9 1992 We conclude that the severe pathophysiological changes characterizing the J-HR occurring on penicillin treatment of louse-borne relapsing fever are closely associated with transient elevation of plasma TNF, IL-6, and -8 concentrations. Penicillins 92-102 interleukin 6 Homo sapiens 207-219 8301142-12 1994 These studies demonstrate that RA and other retinoid analogs inhibit IL-1-induced IL-6 production and that this effect is analog-specific and, at least partially, transcriptionally mediated. Retinoids 44-52 interleukin 6 Homo sapiens 82-86 22192353-8 2012 RESULT(S): Treatment of stromal cells with thiazolidinediones attenuated IL-6 and IL-8 release in a dose-dependent manner. Thiazolidinediones 43-61 interleukin 6 Homo sapiens 73-77 7766145-5 1994 Recombinant BHK-21 cells producing hIL-6 under the control of the CMV promoter were contransfected with the ras oncogene and dihydrofolate reductase gene, then selected with 50 nM methotrexate to coamplify the ras oncogene. Methotrexate 180-192 interleukin 6 Homo sapiens 35-40 22192353-11 2012 CONCLUSION(S): Thiazolidinediones decrease the proinflammatory cytokines IL-6 and IL-8 in endometrial stromal cells via a PPAR-gamma-independent mechanism. Thiazolidinediones 15-33 interleukin 6 Homo sapiens 73-77 1546322-2 1992 Salicylate activation of DNA binding by the heat shock transcription factor (HSF) was comparable to activation attained during heat shock. Salicylates 0-10 interleukin 6 Homo sapiens 44-75 1546322-2 1992 Salicylate activation of DNA binding by the heat shock transcription factor (HSF) was comparable to activation attained during heat shock. Salicylates 0-10 interleukin 6 Homo sapiens 77-80 21907687-12 2012 Pyridoxamine and aminoguanidine inhibited the endogenous CML formation and the increased RAGE, PAI-1, IL-8, IL-6, and CRP expression. pimagedine 17-31 interleukin 6 Homo sapiens 108-112 1546322-5 1992 Modulation of extracellular pH augments sensitivity to salicylate-induced activation of HSF. Salicylates 55-65 interleukin 6 Homo sapiens 88-91 8020547-3 1994 Binding experiments with 125I-labeled IL-6 showed that IL-6R were expressed at a high density on RPMI-8226 cells (15 000 receptors/cell), but no specific binding was detected on XG-1 cells, whose growth depends on the presence of exogenous IL-6. Iodine-125 25-29 interleukin 6 Homo sapiens 38-42 8020547-3 1994 Binding experiments with 125I-labeled IL-6 showed that IL-6R were expressed at a high density on RPMI-8226 cells (15 000 receptors/cell), but no specific binding was detected on XG-1 cells, whose growth depends on the presence of exogenous IL-6. Iodine-125 25-29 interleukin 6 Homo sapiens 55-59 1955561-3 1991 injection of 0.08 mg/kg midazolam induced a marked and delayed inhibition of the lipopolysaccharide-induced production of interleukin-1 beta, tumor necrosis factor-alpha and interleukin-6 by monocytes isolated from peripheral blood. Midazolam 24-33 interleukin 6 Homo sapiens 174-187 22221092-6 2012 Thiazolidinediones stimulate PPARg2, by which they down-regulate tumour necrosis factor-alpha, leptin, interleukin-6 and plasminogen and also enhance insulin sensitivity. Thiazolidinediones 0-18 interleukin 6 Homo sapiens 103-116 1872826-2 1991 We investigated the effect of chemically synthesized substances, 1,1"-ethylidene bis[tryptophan] (EBT) and its decomposition product, 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid (MTCA) recently identified in the implicated LT, on the eosinophil differentiation and the induction of IL-1 and IL-6. 1,1'-ethylidene bis(tryptophan) 98-101 interleukin 6 Homo sapiens 308-312 8187811-3 1994 Therefore the effects of a low-dose therapy with methotrexate on serum concentrations of interleukin-6 (IL-6) and tumour-necrosis-factor-alpha (TNF-alpha) were examined in eight patients with seropositive rheumatoid arthritis. Methotrexate 49-61 interleukin 6 Homo sapiens 89-102 8187811-3 1994 Therefore the effects of a low-dose therapy with methotrexate on serum concentrations of interleukin-6 (IL-6) and tumour-necrosis-factor-alpha (TNF-alpha) were examined in eight patients with seropositive rheumatoid arthritis. Methotrexate 49-61 interleukin 6 Homo sapiens 104-108 22119708-4 2012 The release of the pro-inflammatory cytokines IL-6 and TNF-alpha was evaluated in lipolysaccharide (LPS)-stimulated human peripheral blood leukocytes (hPBL) and in the human promyelocytic cell line THP-1, while the release of IL-10 and IFN-gamma was evaluated in phytohemagglutinin (PHA)-stimulated hPBL. lipolysaccharide 82-98 interleukin 6 Homo sapiens 46-50 7694064-2 1993 The elevation of s-IL6 on the first postoperative day was only correlated with preoperative values of indocyanine green retention test (ICG-R15) (r = 0.56, p < 0.01), and not concerned with any operative factors. Indocyanine Green 102-119 interleukin 6 Homo sapiens 19-22 1664173-6 1991 Conversely, the preincubation of pituitary cells with interleukin-6 for 20 min significantly reduced VIP- and forskolin-stimulated adenylate cyclase activity, as well as inositol phosphate production and free cytosolic calcium increase induced by TRH. Colforsin 110-119 interleukin 6 Homo sapiens 54-67 2050135-8 1991 Purified recombinant human interleukin-6 is biologically active because it is able to induce at least 70-fold the human C-reactive promoter transfected in human hepatoma Hep 3B cells and is stable for several months in 10% glycerol at 4 degrees C. The expression system described in the present work has the main advantage of producing a high yield of recombinant human interleukin-6 (about 25 mg/l) combined with a very simple purification scheme. Glycerol 223-231 interleukin 6 Homo sapiens 27-40 8156173-1 1993 Using reverse transcriptase-linked polymerase chain reaction, the effect of polycyclic aromatic hydrocarbons (PAHs) on IL-1 alpha, IL-1 beta and IL-6 gene expression in cultured human keratinocytes was studied. Polycyclic Aromatic Hydrocarbons 76-108 interleukin 6 Homo sapiens 145-149 21602258-3 2012 The plasma levels of CRP, P-selectin, sCD40L, IL-6 was higher in 65 (18.5%) patients with clopidogrel resistance than in those with normal responsiveness at 6 months after PCI. Clopidogrel 90-101 interleukin 6 Homo sapiens 46-50 8156173-1 1993 Using reverse transcriptase-linked polymerase chain reaction, the effect of polycyclic aromatic hydrocarbons (PAHs) on IL-1 alpha, IL-1 beta and IL-6 gene expression in cultured human keratinocytes was studied. Polycyclic Aromatic Hydrocarbons 110-114 interleukin 6 Homo sapiens 145-149 7682247-5 1993 The level of activated HSF binding to HSE was higher in cells treated with low doses (1 ng/ml) of bleomycin than in cells treated with 1 or 25 micrograms/ml bleomycin. Bleomycin 157-166 interleukin 6 Homo sapiens 23-26 2009973-5 1991 However, blockade of PKC by the isoquinoline sulfonamide derivative H7 and thus inhibition of phosphorylation was associated with augmentation of the fibroblasts response to TNF-alpha and IL-6. isoquinoline sulfonamide 32-56 interleukin 6 Homo sapiens 188-192 1997727-8 1991 of IL-6 demonstrated enhanced proliferation as determined by 3H-thymidine uptake. 3h-thymidine 61-73 interleukin 6 Homo sapiens 3-7 23092137-3 2012 The ability of retinoids to exert antioxidant effects, inhibit amyloid-beta (Abeta) deposits and likely Abeta-induced mitochondrial dysfunction, tau hyperphosphorylation, Abeta-induced IL6 production and neuroinflammation, increase survival in hippocampal neurons, and reverse cognitive deficits in animal models of Alzheimer"s disease (AD) is discussed. Retinoids 15-24 interleukin 6 Homo sapiens 185-188 1989890-5 1991 After phorbol ester myristate acetate (PMA) treatment, all the cell lines studied expressed or overexpressed IL-6. phorbol ester myristate acetate 6-37 interleukin 6 Homo sapiens 109-113 2046859-0 1991 Release of interleukin-6 from anterior pituitary cell aggregates: developmental pattern and modulation by glucocorticoids and forskolin. Colforsin 126-135 interleukin 6 Homo sapiens 11-24 2046859-4 1991 The adenylate cyclase activator forskolin increased IL-6 release in aggregate cultures in the presence of DEX. Colforsin 32-41 interleukin 6 Homo sapiens 52-56 2163835-1 1990 Affinity cross-linking of 125I-labeled recombinant human interleukin-6 (IL-6) to human hepatoma cells (HepG2) allowed the detection of three IL-6-containing complexes with molecular masses of 100 kDa, 120 kDa and 200 kDa. Iodine-125 26-30 interleukin 6 Homo sapiens 57-70 2163835-1 1990 Affinity cross-linking of 125I-labeled recombinant human interleukin-6 (IL-6) to human hepatoma cells (HepG2) allowed the detection of three IL-6-containing complexes with molecular masses of 100 kDa, 120 kDa and 200 kDa. Iodine-125 26-30 interleukin 6 Homo sapiens 72-76 2163835-1 1990 Affinity cross-linking of 125I-labeled recombinant human interleukin-6 (IL-6) to human hepatoma cells (HepG2) allowed the detection of three IL-6-containing complexes with molecular masses of 100 kDa, 120 kDa and 200 kDa. Iodine-125 26-30 interleukin 6 Homo sapiens 141-145 8392160-1 1993 The nucleoside analog acyclovir is remarkably effective and selective in herpes simplex virus (HSF) infections. Nucleosides 4-14 interleukin 6 Homo sapiens 95-98 8392160-1 1993 The nucleoside analog acyclovir is remarkably effective and selective in herpes simplex virus (HSF) infections. Acyclovir 22-31 interleukin 6 Homo sapiens 95-98 8492420-12 1993 Treatment with prednisolone and melphalan resulted in improvement of clinical findings such as anemia, lymph node swelling and hypergammaglobulinemia in concurrence with decrease in serum levels of IL-6. Melphalan 32-41 interleukin 6 Homo sapiens 198-202 1327882-0 1992 Role of leucine residues in the C-terminal region of human interleukin-6 in the biological activity. Leucine 8-15 interleukin 6 Homo sapiens 59-72 22110547-7 2012 In addition, EBNE-induced production of IL-6 and VEGF was inhibited by PD98059 (a p44/42 MAPK inhibitor), SB203580 (a p38 MAPK inhibitor), and PDTC (a NF-kappaB inhibitor), but not SP600125 (a JNK inhibitor). pyrazolanthrone 181-189 interleukin 6 Homo sapiens 40-44 1319454-4 1992 IL-6 release over 24 h was stimulated by TSH (5000 microU/ml), by forskolin (0.01 mmol/l), by fetal calf serum (1-20%) and by epidermal growth factor (20 ng/ml). Colforsin 66-75 interleukin 6 Homo sapiens 0-4 2371251-2 1990 Using an IL-6-dependent cell line, MH6o.BSF2, we showed that the placenta released IL-6 into the culture supernatant. mh6o 35-39 interleukin 6 Homo sapiens 9-13 2371251-2 1990 Using an IL-6-dependent cell line, MH6o.BSF2, we showed that the placenta released IL-6 into the culture supernatant. mh6o 35-39 interleukin 6 Homo sapiens 83-87 21907269-1 2011 Assessment of the UV protecting potential of an aqueous methanol leaf extract of Harpephyllum caffrum proved that it possesses a distinct radical scavenging effect and inhibits the production of the proinflammatory cytokine IL-6 by human keratinocytes (HaCaT cells) following UV radiation. Methanol 56-64 interleukin 6 Homo sapiens 224-228 1547025-0 1992 Modulation of lipopolysaccharide-induced production of tumor necrosis factor, interleukin 1, and interleukin 6 by synthetic precursor Ia of lipid A. Lipid A 140-147 interleukin 6 Homo sapiens 97-110 1547025-2 1992 In the present study we have investigated the modulation of LPS by the synthetic non-active tetraacylated precursor Ia of lipid A (compound 406) in the induction of tumor necrosis factor (TNF), interleukin 1 (IL-1) and interleukin 6 (IL-6) in human peripheral blood mononuclear cells (PBMC) and in human peripheral blood monocytes (PBMo). Lipid A 122-129 interleukin 6 Homo sapiens 219-232 23268452-6 2011 IL-6 production in the supernatants of confluent monolayers cultured in the presence of the drugs or forskolin (24 h) was analyzed by enzyme-linked immunosorbent assay. Colforsin 101-110 interleukin 6 Homo sapiens 0-4 1547025-2 1992 In the present study we have investigated the modulation of LPS by the synthetic non-active tetraacylated precursor Ia of lipid A (compound 406) in the induction of tumor necrosis factor (TNF), interleukin 1 (IL-1) and interleukin 6 (IL-6) in human peripheral blood mononuclear cells (PBMC) and in human peripheral blood monocytes (PBMo). Lipid A 122-129 interleukin 6 Homo sapiens 234-238 33813346-7 2021 RESULTS: In adjusted models we observed positive associations of monocarboxynonyl phthalate (MCNP) with CRP (beta = 0.092; 95% CI 0.026, 0.158) and IL-6 (beta = 0.108; 95% CI 0.013, 0.204). mcnp 93-97 interleukin 6 Homo sapiens 148-152 33793190-2 2021 SPEs are functionalized with antibodies specific for IL-6 through electrodeposition of a diazonium linking group and N"-ethylcarbodiimide hydrochloride (EDC) coupling, which was tracked through the use of cyclic voltammetry and Raman spectroscopy. n"-ethylcarbodiimide hydrochloride 117-151 interleukin 6 Homo sapiens 53-57 21910986-5 2011 Pretreatment with the HO-1 inhibitor, tin protoporphyrin (SnPP), attenuated the inhibitory activities of LA on LPS-induced inflammatory NO, PGE(2), IL-1beta, TNF-alpha, IL-6 and IL-12 production. tin protoporphyrin IX 38-56 interleukin 6 Homo sapiens 169-173 33779886-9 2021 IL-6 overexpression could abrogate BMSC-Exo-induced balance in Th17/Treg ratio. treg 68-72 interleukin 6 Homo sapiens 0-4 1283251-11 1992 A supposed cytokine produced by neoplastic cells dependent from their proliferative activity may induce Il-6 secretion by TAM. tam 122-125 interleukin 6 Homo sapiens 104-108 1937825-0 1991 Inhibition of endotoxin-induced interleukin-6 production by synthetic lipid A partial structures in human peripheral blood mononuclear cells. Lipid A 70-77 interleukin 6 Homo sapiens 32-45 22088587-13 2011 CONCLUSION: Flavonoids of puerarin can restrain the increase of IL-6 after acute ischemic stroke, and depress the LDH raised by reperfusion after cerebral ischemia. Flavonoids 12-22 interleukin 6 Homo sapiens 64-68 1937825-3 1991 The maximum release of interleukin-6 was found after stimulation with 1 to 10 ng of lipopolysaccharide or 10 to 100 ng of synthetic E. coli-type lipid A per ml. Lipid A 145-152 interleukin 6 Homo sapiens 23-36 1937825-5 1991 However, they inhibited lipopolysaccharide- or lipid A-induced interleukin-6 production in a dose-dependent manner. Lipid A 47-54 interleukin 6 Homo sapiens 63-76 33771857-14 2021 Adding interferon-alpha increased toxicities but was tolerable, and reduced human Treg numbers in blood, and function through dendritic cell-induced IL-6 in vitro Conclusions: Treg depletion is clinically useful but unlikely alone to cure OC. treg 176-180 interleukin 6 Homo sapiens 149-153 21839074-4 2011 Serum proinflammatory cytokines such as IL-1beta, IL-6, TNF-alpha and GM-CSF and also serum NO levels were significantly reduced by the treatment of nomilin. nomilin 149-156 interleukin 6 Homo sapiens 50-54 33809417-10 2021 Low-dose garcinol did not affect cardiomyocyte viability but significantly reduced mitochondrial ROS, CRP, IL-1beta, IL-6, and TNF-alpha production in Lp(a)-stimulated cardiomyocytes (p < 0.05). garcinol 9-17 interleukin 6 Homo sapiens 117-121 33804152-0 2021 13R,20-Dihydroxydocosahexaenoic Acid, a Novel Dihydroxy- DHA Derivative, Inhibits Breast Cancer Stemness through Regulation of the Stat3/IL-6 Signaling Pathway by Inducing ROS Production. 13r,20-dihydroxydocosahexaenoic acid 0-36 interleukin 6 Homo sapiens 137-141 34078115-6 2022 IL-6 inhibitors (sirukumab, tocilizumab, sarilumab) significantly enhance metabolism via CYP2C9 (s-warfarin), CYP2C19 (omeprazole), and CYP3A4 (simvastatin, midazolam) and reduce metabolism via CYP1A2 (caffeine). Warfarin 99-107 interleukin 6 Homo sapiens 0-4 34078115-6 2022 IL-6 inhibitors (sirukumab, tocilizumab, sarilumab) significantly enhance metabolism via CYP2C9 (s-warfarin), CYP2C19 (omeprazole), and CYP3A4 (simvastatin, midazolam) and reduce metabolism via CYP1A2 (caffeine). Midazolam 157-166 interleukin 6 Homo sapiens 0-4 2287944-7 1990 MTX has crucial effects on the cascade of events initiated by some cytokines (IL-1, IL-6, tumor necrosis factor), which plays a major role in RA and other inflammatory diseases. Methotrexate 0-3 interleukin 6 Homo sapiens 84-88 2233715-3 1990 The induction by interleukin-1, tumor necrosis factor, phorbol ester, or forskolin of IL-6-tk-cat chimeric constructs containing a single copy of the IL-6 DNA segment from -173 to -151 (MRE I) or from -158 to -145 (MRE II), which derive from within the multiple cytokine- and second-messenger-responsive enhancer (MRE) region, was strongly repressed by Dex in a wild-type GR-dependent fashion irrespective of the inducer used. Colforsin 73-82 interleukin 6 Homo sapiens 86-90 2119238-9 1990 Human BMMC proteoglycan synthesis shifted from approximately 85% chondroitin sulfate E to approximately 60% heparin within 14 to 19 days of coculture with the MESF monolayer and to approximately 50% heparin within 19 days of coculture with the HSF monolayer. mesf 159-163 interleukin 6 Homo sapiens 244-247 21795297-7 2011 Following clopidogrel withdrawal, there was (i) a predictable increase in ADP-induced platelet aggregation (ii) an unexpected significant increase in AA-induced platelet aggregation (iii) a decline in IL-6 and hsCRP at 1 week and 4 weeks respectively; and (iv) a non-significant increase in sCD40L at 4 weeks TXB(2) levels were consistently suppressed, indicating complete inhibition of cyclo-oxygenase-1 by aspirin. Clopidogrel 10-21 interleukin 6 Homo sapiens 201-205 2192263-3 1990 On the basis of these and other experiments, we conclude that TNF and IL-1 apparently activate IL-6 gene expression by closely related mechanisms involving activation of a NF-kappa B-like factor, whereas the pathway of IL-6 induction by forskolin is, in part, different. Colforsin 237-246 interleukin 6 Homo sapiens 219-223 34613549-9 2022 We found that suppressing phosphorylation of the JNK1/2 and p38 MAPK signaling pathways inhibited IL-6, MCP-1, and sICAM-1 secretion, implicating these pathways and NF-kappaB suppression in the effects of oleuropein. oleuropein 205-215 interleukin 6 Homo sapiens 98-102 21821055-0 2011 Dimethyl sulphoxide and dimethyl sulphone are potent inhibitors of IL-6 and IL-8 expression in the human chondrocyte cell line C-28/I2. dimethyl sulfone 24-41 interleukin 6 Homo sapiens 67-71 34673277-4 2022 Here, we demonstrate that serum concentrations of TMAO were positively correlated with C-reactive protein (CRP) levels, and the appearance rate of dialysate IL-6 and PAI-1, in PD patients. trimethyloxamine 50-54 interleukin 6 Homo sapiens 157-161 34688839-6 2022 In addition, the GFA treatment was able to reduce the percentage of infected cells and the number of amastigotes per macrophage (J774A.1) without showing cytotoxicity in mammalian cell lines (J774A.1, LLCMK2, THP-1, AMJ2-C11), in addition to increasing TNF-alpha and reducing IL-6 levels in infected macrophages. grandiflorenic acid 17-20 interleukin 6 Homo sapiens 276-280 2337412-3 1990 These kinetic parameters were utilized subsequently to evaluate the inhibitory effects of manoalide on HSF-PLA2. manoalide 90-99 interleukin 6 Homo sapiens 103-106 2105994-8 1990 Although IFN-gamma, IL-6, granulocyte CSF, and granulocyte-macrophage CSF-induced nitroblue tetrazolium reducing activity of U-937 cells, only IFN-gamma, and TNF induced it synergistically in combination with TGF-beta 1. Nitroblue Tetrazolium 82-103 interleukin 6 Homo sapiens 20-24 2407240-3 1990 Other stimulators of interleukin 6 production in chondrocytes include tumour necrosis factor-alpha, polyriboinosinic: polyribocytidylic acid and bacterial lipopolysaccharide. polyriboinosinic 100-116 interleukin 6 Homo sapiens 21-34 21821055-8 2011 Long-term exposure of cells to DMSO (1%) or DMS (100mM) led to a dramatic downregulation of IL-6 and IL-8 expression which was accompanied by the deactivation of ERK1/2. dimethyl sulfone 31-34 interleukin 6 Homo sapiens 92-96 21821055-10 2011 SIGNIFICANCE: In this study, we demonstrate that both DMSO and DMS represent strong anti-inflammatory properties by blocking constitutive as well as IL-1beta-induced IL-6 and IL-8 expression in the human chondrocyte cell line C-28/I2. dimethyl sulfone 54-57 interleukin 6 Homo sapiens 166-170 34643298-4 2022 RESULTS: (18 F)-FEMPA binding was significantly increased in the dentate nuclei (d = 0.67), superior cerebellar peduncles (d = 0.74), and midbrain (d = 0.87), alongside increased plasma interleukin-6 (IL-6) (d = 0.73), in individuals with FRDA compared to controls. UNII-YK1TJO93VQ 16-21 interleukin 6 Homo sapiens 186-199 34643298-4 2022 RESULTS: (18 F)-FEMPA binding was significantly increased in the dentate nuclei (d = 0.67), superior cerebellar peduncles (d = 0.74), and midbrain (d = 0.87), alongside increased plasma interleukin-6 (IL-6) (d = 0.73), in individuals with FRDA compared to controls. UNII-YK1TJO93VQ 16-21 interleukin 6 Homo sapiens 201-205 22166738-11 2011 The inflammatory response estimated with CRP, IL-6 concentration in blood serum was considerably higher in patients operated with Stoppa method. stoppa 130-136 interleukin 6 Homo sapiens 46-50 34915523-8 2021 Picropodophyllin, a specific inhibitor of IGF1R, increased the expression of p-ERK protein, and decreased the transcription level of interleukin-6. picropodophyllin 0-16 interleukin 6 Homo sapiens 133-146 33590951-10 2021 Pretreatment of MDMs from COPD patients with SFN significantly suppressed Pam3CSK4- or LPS-induced TLR2, TLR4 and MyD88 expression, along with a reduction in the production of IL-6 and TNF-alpha (P < 0.05). sulforaphane 45-48 interleukin 6 Homo sapiens 176-180 33818279-7 2022 Consistent with the Ca2+-releasing activity of NAADP, intracellular Ca2+ chelation and PPP3/calcineurin inhibition prevented TFEB activation by phagocytosis and ROS (reactive oxygen species), impairing the induction of pro-inflammatory cytokines such as IL6 and TNF/TNFalpha. NAADP 47-52 interleukin 6 Homo sapiens 254-257 21871109-11 2011 Both IL-6 (r = 0.624, p < 0.01) and MMP-9/TIMP-1 (r = 0.56, p < 0.02) correlated with admission NIHSS. nihss 102-107 interleukin 6 Homo sapiens 5-9 34480250-0 2022 Repurposing Methotrexate in Dampening SARS-CoV2-S1-Mediated IL6 Expression: Lessons Learnt from Lung Cancer. Methotrexate 12-24 interleukin 6 Homo sapiens 60-63 34480250-6 2022 Western blot and qRT-PCR analysis suggested that treatment with methotrexate (MTx) dampened CoV-2-SRBD-mediated increase in JAK1/STAT3 phosphorylation, gp130, IL6, and folate-binding protein (FBP) expressions. Methotrexate 64-76 interleukin 6 Homo sapiens 159-162 34480250-6 2022 Western blot and qRT-PCR analysis suggested that treatment with methotrexate (MTx) dampened CoV-2-SRBD-mediated increase in JAK1/STAT3 phosphorylation, gp130, IL6, and folate-binding protein (FBP) expressions. Methotrexate 78-81 interleukin 6 Homo sapiens 159-162 34882521-9 2022 Interfering circ_0073748 and reinforcing miR-132-3p improved cell viability, EdU incorporation, and superoxide dismutase (SOD) activity of caerulein-treated HPDE6-C7 cells but suppressed malonaldehyde (MDA), IL-6 and TNF-alpha levels and apoptosis rate. Ceruletide 139-148 interleukin 6 Homo sapiens 208-212 21814029-3 2011 The combinational use of methotrexate and biologics targeting TNF and IL-6 has revolutionized the treatment of RA, producing significant improvements in clinical and structural outcomes. Methotrexate 25-37 interleukin 6 Homo sapiens 70-74 34388475-0 2021 Oleanolic acid regulates the Treg/Th17 imbalance in gastric cancer by targeting IL-6 with miR-98-5p. Oleanolic Acid 0-14 interleukin 6 Homo sapiens 80-84 34388475-0 2021 Oleanolic acid regulates the Treg/Th17 imbalance in gastric cancer by targeting IL-6 with miR-98-5p. treg 29-33 interleukin 6 Homo sapiens 80-84 34570917-15 2022 Knockdown of cGAS or STING, as well as using cGAS inhibitor G140 or STING inhibitor H-151 abolished the IFN-beta, TNF, and IL-6 production induced by ISD transfection. H-151 84-89 interleukin 6 Homo sapiens 123-127 34570917-16 2022 Knockdown of STING or using STING inhibitor H-151 abolished the IFN-beta, TNF, and IL-6 induction by transfection of bacterial and host cyclic dinucleotides. H-151 44-49 interleukin 6 Homo sapiens 83-87 34862831-9 2022 EEP + DTX exerted no cytotoxic effects on monocytes and stimulated HLA-DR expression, TNF-alpha, and IL-6 production, exerted an immunorestorative action in the fungicidal activity, and reduced the oxidative stress. Docetaxel 6-9 interleukin 6 Homo sapiens 101-105 34688667-9 2021 These data provide a biochemical mechanism by which CD4+ T cells integrate TCR, TGF-beta, and IL-6 signals via generation of alternate SMAD3 complexes that control the development of early signaling networks to potentiate the choice of Treg versus Th17 cell fate. treg 236-240 interleukin 6 Homo sapiens 94-98 21756313-8 2011 Conversely, the NO donor, sodium nitroprusside, markedly increased mRNA expression of Mac-1, interleukin-6, toll-like receptor 4 and P2X4 receptor. Nitroprusside 26-46 interleukin 6 Homo sapiens 93-128 34218397-12 2021 This phytocannabinoid also partially reversed LPS-evoked IL-6 increase in both the hypothalamus and hippocampus. phytocannabinoid 5-21 interleukin 6 Homo sapiens 57-61 33739906-3 2021 TA-loaded PLC NPs exhibited excellent anti-inflammatory activity against human corneal epithelial (HCE) cells and significantly reduced the secretion of interleukin (IL)-6 in tumour necrosis factor (TNF)-alpha activated cells. Triamcinolone Acetonide 0-2 interleukin 6 Homo sapiens 153-171 21518761-9 2011 Our findings show that the presence of IL-1 and/or IL-6 during activation of human CD8 T cells attenuates Fas-mediated AICD, whereas IL-12 increases the susceptibility of activated CD8 T cells to this form of cell death. ammonium ferrous sulfate 106-109 interleukin 6 Homo sapiens 51-55 34308769-8 2021 At the same time, sulforaphane weakened the ability of LPS to induce production of inflammatory cytokines (IL-1beta, IL-6, IL-8 and TNF-alpha) and the pro-apoptotic caspases-3 and -9. sulforaphane 18-30 interleukin 6 Homo sapiens 117-121 34607229-6 2021 Furthermore, the expression of platelet-activating factor receptor (PAFR) in astrocytes was induced by CPZ feeding and LPS stimulation, accompanied by the increase of inflammatory cytokines TNF-alpha,IL-6 and IL-1beta. Cuprizone 103-106 interleukin 6 Homo sapiens 200-204 34729750-13 2021 Down-regulating miR-363-3p attenuated the inhibitory effect of down-regulating si-HNF1A-AS1 on the proliferation, migration and invasion of HemEC cells induced by IL-6 (P<0.05). mir-363-3p 16-26 interleukin 6 Homo sapiens 163-167 34803913-7 2021 Quercetin significantly reduced plasma markers of cell damage (CK (p<0.005), LDH (p<0.001) and Mb (p<0.05)) and the interleukin 6 level (IL-6 (p<0.05)) during recovery period following EIMD compared to placebo. Quercetin 0-9 interleukin 6 Homo sapiens 116-129 34803913-7 2021 Quercetin significantly reduced plasma markers of cell damage (CK (p<0.005), LDH (p<0.001) and Mb (p<0.05)) and the interleukin 6 level (IL-6 (p<0.05)) during recovery period following EIMD compared to placebo. Quercetin 0-9 interleukin 6 Homo sapiens 137-141 21349943-5 2011 RESULTS: PGE(2) significantly attenuated the expressions of chemokine (C-C) motif ligand (CCL) 5, chemokine (C-X-C motif) ligand (CXCL) 10, CXCL11 and interleukin (IL) 6 in PHCjECs. Prostaglandins E 9-12 interleukin 6 Homo sapiens 151-169 34539828-4 2021 ALA/DHLA reduce the levels of pro-inflammatory cytokines (IL-1beta, IL-6, IL-8 and IL-17), while increasing the secretion of anti-inflammatory cytokines (IL-10). dihydrolipoic acid 4-8 interleukin 6 Homo sapiens 68-72 34666245-6 2021 Here, we show that Trelagliptin mitigates IL-1beta-induced production of inflammatory cytokines such as interleukin 6 (IL-6), interleukin 8 (IL-8), and tumor necrosis factor-alpha (TNF-alpha) in human chondrocytes. trelagliptin 19-31 interleukin 6 Homo sapiens 104-117 34666245-6 2021 Here, we show that Trelagliptin mitigates IL-1beta-induced production of inflammatory cytokines such as interleukin 6 (IL-6), interleukin 8 (IL-8), and tumor necrosis factor-alpha (TNF-alpha) in human chondrocytes. trelagliptin 19-31 interleukin 6 Homo sapiens 119-123 34648407-12 2021 Besides, SIRT3, IL-6 and TNF-alpha were the independent risk factors for MM patients developing PN after treatment of bortezomib. Bortezomib 118-128 interleukin 6 Homo sapiens 16-20 21349943-10 2011 CONCLUSION: Our results show that PGE(2) attenuated the expression of CCL5, CXCL10 and CXCL11 via both EP2 and EP3, and that the expression of IL-6 was attenuated only by EP3. Prostaglandins E 34-37 interleukin 6 Homo sapiens 143-147 34672136-7 2021 RESULTS: U937 cells treated with CpG-ODN induced activation of the NF-kappaB pathway and increased the expression of the pro-inflammatory cytokines IL-1beta, TNF-alpha, and IL-6, but reduced that of IL-37. CPG-oligonucleotide 33-40 interleukin 6 Homo sapiens 173-177 21474332-3 2011 Capsaicin-treated PC-3 cells increased the synthesis and secretion of IL-6 which was abrogated by the transient receptor potential vanilloid receptor subtype 1 (TRPV1) antagonist capsazepine, as well as by inhibitors of PKC-alpha, phosphoinositol-3 phosphate kinase (PI-3K), Akt and extracellular signal-regulated protein kinase (ERK). capsazepine 179-190 interleukin 6 Homo sapiens 70-74 34672136-9 2021 Human macrophages transfected with IL-37 siRNA augmented the expression of IL-1beta, TNF-alpha, and IL-6 mRNA and protein in cells treated with CpG-ODN. CPG-oligonucleotide 144-151 interleukin 6 Homo sapiens 100-104 34856488-5 2021 The results showed that endosulfan significantly promoted cell proliferation, accompanied with the decrease of p27 mRNA expression and the increase in the mRNA expression levels of p21 and inflammatory factors IL-6/IL-8. Endosulfan 24-34 interleukin 6 Homo sapiens 210-214 20945380-7 2011 In contrast, PGN-induced IL-6 mRNA and protein up-regulation were attenuated by the SAPK/JNK (c-Jun N-terminal kinases) inhibitor SP600125. pyrazolanthrone 130-138 interleukin 6 Homo sapiens 25-29 34867348-7 2021 We showed that LPS-induced expression of IL-6 and IL-1beta was cAMP dependent, that IL-6 and IL-1beta expression were induced by direct cAMP activation (forskolin) and that RG0216 and deprenyl effectively reduced cAMP-mediated cytokine expression. Colforsin 153-162 interleukin 6 Homo sapiens 41-45 34867348-7 2021 We showed that LPS-induced expression of IL-6 and IL-1beta was cAMP dependent, that IL-6 and IL-1beta expression were induced by direct cAMP activation (forskolin) and that RG0216 and deprenyl effectively reduced cAMP-mediated cytokine expression. Colforsin 153-162 interleukin 6 Homo sapiens 84-88 34754315-10 2021 Molecular docking results showed that quercetin, luteolin, kaempferol, tanshinone IIa, wogonin, naringenin, nobiletin, dihydrotanshinlactone, beta-sitosterol, and salviolone have good affinity with core target proteins IL6, PTGS2, MAPK1, MAPK3, and CGRP1. Quercetin 38-47 interleukin 6 Homo sapiens 219-222 20945380-13 2011 Co-transfection with dominant negative mutant of JNK (DN-JNK), or treatment with SP600125, curcumin, or Tanshinone IIA effectively antagonized PGN-increased IL-6 transcription activity. pyrazolanthrone 81-89 interleukin 6 Homo sapiens 157-161 21214673-3 2011 Changes in the growth and sensitivity to docetaxel in PC3/sh-IL6 were compared with those in PC3 transfected with control vector alone (PC3/Co). Docetaxel 41-50 interleukin 6 Homo sapiens 61-64 34746302-16 2021 The hub components possibly include quercetin, stigmasterol, kaempferol, and beta-sitosterol and act through pairing with hub targets, such as AKT1, VEGFA, and IL6, to regulate neuronal death, G protein-coupled amine receptor activity, reactive oxygen species metabolic process, membrane raft, MAPK signaling pathway, and cellular senescence for the treatment of PD. Quercetin 36-45 interleukin 6 Homo sapiens 160-163 34746302-16 2021 The hub components possibly include quercetin, stigmasterol, kaempferol, and beta-sitosterol and act through pairing with hub targets, such as AKT1, VEGFA, and IL6, to regulate neuronal death, G protein-coupled amine receptor activity, reactive oxygen species metabolic process, membrane raft, MAPK signaling pathway, and cellular senescence for the treatment of PD. Amines 211-216 interleukin 6 Homo sapiens 160-163 34400395-7 2021 This Slit2-mediated increase in M1-TAM phagocytosis occurred via suppression of IL6. tam 35-38 interleukin 6 Homo sapiens 80-83 34581012-5 2022 Upon blockade of the IL-6 signaling pathway by an anti-IL-6 treatment, the AUCs of S-warfarin, omeprazole and midazolam were predicted to decrease by up to 40%, 42%, and 46%, respectively. Warfarin 83-93 interleukin 6 Homo sapiens 21-25 34889899-10 2021 The MDT confirmed that two key activators (beta-Amyrone, beta-Stigmasterol) bound most stably to PPARA, PPARD, PPARG, FABP3, FABP4, and NR1H3 on the PPAR signaling pathway, also, three key inhibitors (Neotocopherol, Xanthosine, and beta-Amyrone) bound most tightly to AKT1, IL6, FGF2, and PHLPP1 on the PI3K-Akt signaling pathway. xanthosine 216-226 interleukin 6 Homo sapiens 274-277 34390919-11 2021 5-MP suppresses the pro-inflammatory IL-6 release from SAA-activated cells, but not from non-activated cells. 5-mp 0-4 interleukin 6 Homo sapiens 37-41 34425162-4 2021 Pretreatment of HNE cells with the specific vacuolar H+-ATPase inhibitor bafilomycin A1 reduced the RV-C03 RNA levels in the ASL; inflammatory cytokines, including interleukin (IL)-1beta, IL-6 and IL-8, in the supernatant; the mRNA expression of the RV-C receptor cadherin-related family member 3 (CDHR3) in the cells; and the number of acidic endosomes where RV-B RNA enters the cytoplasm. bafilomycin A1 73-87 interleukin 6 Homo sapiens 188-192 34581012-5 2022 Upon blockade of the IL-6 signaling pathway by an anti-IL-6 treatment, the AUCs of S-warfarin, omeprazole and midazolam were predicted to decrease by up to 40%, 42%, and 46%, respectively. Warfarin 83-93 interleukin 6 Homo sapiens 55-59 21214673-6 2011 Despite the higher sensitivity of PC3/sh-IL6 to docetaxel than that of PC3/Co, the secretion of IL-6 by both cell lines was increased after treatment with docetaxel due to the formation of positive autocrine loops between these cell lines and NFkappaB signaling pathways. Docetaxel 48-57 interleukin 6 Homo sapiens 41-44 34581012-5 2022 Upon blockade of the IL-6 signaling pathway by an anti-IL-6 treatment, the AUCs of S-warfarin, omeprazole and midazolam were predicted to decrease by up to 40%, 42%, and 46%, respectively. Midazolam 110-119 interleukin 6 Homo sapiens 21-25 34581012-5 2022 Upon blockade of the IL-6 signaling pathway by an anti-IL-6 treatment, the AUCs of S-warfarin, omeprazole and midazolam were predicted to decrease by up to 40%, 42%, and 46%, respectively. Midazolam 110-119 interleukin 6 Homo sapiens 55-59 34087397-12 2021 Moreover, as the main bioactive compounds of DSS, paeoniflorin (PF), ferulic acid (FA) and pachymic acid (PA) inhibited IL-6 and TNF-alpha secretion as well as IkappaB-alpha, NF-kappaB (p65), p38 and JNK activation. peoniflorin 50-62 interleukin 6 Homo sapiens 120-124 21214673-6 2011 Despite the higher sensitivity of PC3/sh-IL6 to docetaxel than that of PC3/Co, the secretion of IL-6 by both cell lines was increased after treatment with docetaxel due to the formation of positive autocrine loops between these cell lines and NFkappaB signaling pathways. Docetaxel 155-164 interleukin 6 Homo sapiens 41-44 34087397-12 2021 Moreover, as the main bioactive compounds of DSS, paeoniflorin (PF), ferulic acid (FA) and pachymic acid (PA) inhibited IL-6 and TNF-alpha secretion as well as IkappaB-alpha, NF-kappaB (p65), p38 and JNK activation. peoniflorin 64-66 interleukin 6 Homo sapiens 120-124 21214673-6 2011 Despite the higher sensitivity of PC3/sh-IL6 to docetaxel than that of PC3/Co, the secretion of IL-6 by both cell lines was increased after treatment with docetaxel due to the formation of positive autocrine loops between these cell lines and NFkappaB signaling pathways. Docetaxel 155-164 interleukin 6 Homo sapiens 96-100 21214673-7 2011 Furthermore, combined treatment with the proteasome inhibitor bortezomib, which completely inhibited the docetaxel-induced IL-6 secretion via the inactivation of NFkappaB signaling, resulted in the marked sensitization of these cell lines to docetaxel both in vitro and in vivo. Bortezomib 62-72 interleukin 6 Homo sapiens 123-127 21214673-7 2011 Furthermore, combined treatment with the proteasome inhibitor bortezomib, which completely inhibited the docetaxel-induced IL-6 secretion via the inactivation of NFkappaB signaling, resulted in the marked sensitization of these cell lines to docetaxel both in vitro and in vivo. Docetaxel 105-114 interleukin 6 Homo sapiens 123-127 34495872-7 2021 Administration of IPI504 at 0.5-5 muM can significantly inhibit the induction of IL-1beta, IL-6, IL-8, MCP-1 and VEGFA in senescent ARPE-19 and the senescence-mediated migration of retinal capillary endothelial cells in vitro. tanespimycin 18-24 interleukin 6 Homo sapiens 91-95 21214673-8 2011 These findings suggest that suppressed IL-6 secretion using shRNA, either alone or in combination with docetaxel and bortezomib, could be a useful therapeutic strategy against androgen-independent prostate cancer. Docetaxel 103-112 interleukin 6 Homo sapiens 39-43 34688464-5 2021 The results suggested that Neo decreased the levels of interleukin IL-1beta, IL-6, IL-8, TNF-alpha, MMP-3, MMP-9 and MMP-13 in FLSs. neohesperidin 27-30 interleukin 6 Homo sapiens 77-81 34496043-6 2022 Subsequently, the verified model was used to simulate the effect of various clinically observed IL-6 levels on the exposure of LPV/r and midazolam, a CYP3A model drug. Midazolam 137-146 interleukin 6 Homo sapiens 96-100 21214673-8 2011 These findings suggest that suppressed IL-6 secretion using shRNA, either alone or in combination with docetaxel and bortezomib, could be a useful therapeutic strategy against androgen-independent prostate cancer. Bortezomib 117-127 interleukin 6 Homo sapiens 39-43 34493195-7 2022 RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients. shionone 146-154 interleukin 6 Homo sapiens 251-254 34319605-2 2021 In previous reports, genetic factor, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) which is one of the uremic toxins, inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) decreased OATP1B1 activity in vitro, but in vivo effects of these factors have not been elucidated. 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid 37-86 interleukin 6 Homo sapiens 204-217 21547675-0 2011 Chalcones isolated from Angelica keiskei and their inhibition of IL-6 production in TNF-alpha-stimulated MG-63 cell. Chalcones 0-9 interleukin 6 Homo sapiens 65-69 34319605-2 2021 In previous reports, genetic factor, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) which is one of the uremic toxins, inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) decreased OATP1B1 activity in vitro, but in vivo effects of these factors have not been elucidated. 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid 37-86 interleukin 6 Homo sapiens 219-223 34259316-8 2021 Compared with those in the DSS group, the expressions of IL-1beta, IL-6, IL-17, and TNF-alpha in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated. dss 27-30 interleukin 6 Homo sapiens 67-71 34259316-8 2021 Compared with those in the DSS group, the expressions of IL-1beta, IL-6, IL-17, and TNF-alpha in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated. dss 101-104 interleukin 6 Homo sapiens 67-71 20828867-9 2011 The cytokine IL-6 production was significantly increased in ox-LDL treated group and was decreased by quercetin treatment. Quercetin 102-111 interleukin 6 Homo sapiens 13-17 34259316-8 2021 Compared with those in the DSS group, the expressions of IL-1beta, IL-6, IL-17, and TNF-alpha in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated. artenimol 105-108 interleukin 6 Homo sapiens 67-71 34259316-8 2021 Compared with those in the DSS group, the expressions of IL-1beta, IL-6, IL-17, and TNF-alpha in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated. dss 113-116 interleukin 6 Homo sapiens 67-71 34445661-7 2021 The A2AAR agonist CGS 21680 significantly inhibited IL-6 and induced TNF and IL-10 only in RA, while the A2BAR agonist BAY 60-6583 had the same effect in both OA and RA. 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine 18-27 interleukin 6 Homo sapiens 52-56 34380011-9 2021 In QUE pre-treated samples, TNF-alpha and IL-6 were significantly further reduced, indicating the anti-inflammatory role of QUE. Quercetin 3-6 interleukin 6 Homo sapiens 42-46 34380011-9 2021 In QUE pre-treated samples, TNF-alpha and IL-6 were significantly further reduced, indicating the anti-inflammatory role of QUE. Quercetin 124-127 interleukin 6 Homo sapiens 42-46 34308732-7 2021 Quercetin decreased the production of IL-1beta, IL-6, IL-8, TNF-alpha, iNOS, and COX-2, as well as signal transduction via the Akt/AMPK/mTOR pathway. Quercetin 0-9 interleukin 6 Homo sapiens 48-52 21319354-7 2011 After cardiopulmonary bypass, IL-6, IL-8 and MDA levels were significantly increased, and the SOD level was significantly reduced in both two groups, but PF group exhibited lower IL-6, IL-8 and MDA levels and higher SOD levels than the MF group (p < 0.05, respectively). pyrazofurin 154-156 interleukin 6 Homo sapiens 179-183 34302046-10 2021 Treatment with IL-6 inhibitor may be helpful to overcome the low-dose MTX resistance. Methotrexate 70-73 interleukin 6 Homo sapiens 15-19 34407530-16 2022 CONCLUSION: Treatment with CytoSorb in critically ill COVID-19 patients was associated with decreased IL-6 improvement in oxygenation. cytosorb 27-35 interleukin 6 Homo sapiens 102-106 34319853-7 2021 Significant decreases in interleukin- 1 beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) levels were obtained in cultures treated with FA-MTX-BSA NPs compared to the untreated culture in a dose-dependent pattern. Methotrexate 172-175 interleukin 6 Homo sapiens 57-70 34319853-7 2021 Significant decreases in interleukin- 1 beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) levels were obtained in cultures treated with FA-MTX-BSA NPs compared to the untreated culture in a dose-dependent pattern. Methotrexate 172-175 interleukin 6 Homo sapiens 72-76 34214916-9 2021 What"s more, DMEP activated the Nuclear factor-kappaB (NF-kappaB) pathway and levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) were significantly upregulated, causing an inflammatory response. dimethoxyethyl phthalate 13-17 interleukin 6 Homo sapiens 162-175 21609530-5 2011 RESULTS: 8-OHDG and IL-6 secretion of HUVECs was significantly increased significantly after incubated with oxLDL for 24 hours which could be significantly attenuated in the presence of tocopherols and EPA (alone or in combination, all P < 0.05) while the strongest inhibition effects were seen with combined use of mixed-tocopherols and EPA. Tocopherols 186-197 interleukin 6 Homo sapiens 20-24 34214916-9 2021 What"s more, DMEP activated the Nuclear factor-kappaB (NF-kappaB) pathway and levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) were significantly upregulated, causing an inflammatory response. dimethoxyethyl phthalate 13-17 interleukin 6 Homo sapiens 177-181 34517822-9 2021 In addition, treatment with ox-LDL decreased cholesterol efflux, induced aging, and promoted the production of inflammatory cytokines (i.e., IL-6 and tumor necrosis factor TNF-alpha), as well as the expression of Bax and Caspase 3 proteins in VECs. ox-ldl 28-34 interleukin 6 Homo sapiens 141-145 34282193-11 2021 LPS significantly increased secretion of IL-6 by 2.3-fold, which was prevented by pre-incubation with CPZ. capsazepine 102-105 interleukin 6 Homo sapiens 41-45 34114792-7 2021 Markedly, NCO-sP(EO-stat-PO)-rich samples induced a significantly reduced release of proinflammatory cytokines, IL-1beta, IL-6, and IL-8. eo-stat-po 17-27 interleukin 6 Homo sapiens 122-126 21609530-5 2011 RESULTS: 8-OHDG and IL-6 secretion of HUVECs was significantly increased significantly after incubated with oxLDL for 24 hours which could be significantly attenuated in the presence of tocopherols and EPA (alone or in combination, all P < 0.05) while the strongest inhibition effects were seen with combined use of mixed-tocopherols and EPA. Tocopherols 325-336 interleukin 6 Homo sapiens 20-24 21609530-8 2011 CONCLUSION: Combined mixed-tocopherols + EPA use enhanced the inhibiting effects on the secretion of 8-OHDG and IL-6 in oxLDL stimulated HUVECs which might be linked with increased SOD activity and reduced p-PKC activity. Tocopherols 27-38 interleukin 6 Homo sapiens 112-116 34299030-8 2021 TNFalpha stimulated the cytokine expression in FLS, and NDMVs down-regulated TNFalpha-induced expression of IL-5, IL-6, IL-8, MCP-1, IFNgamma and MIP-1beta. ndmvs 56-61 interleukin 6 Homo sapiens 114-118 21302967-0 2011 Blockade of IL-6 secretion pathway by the sesquiterpenoid atractylenolide III. sesquiterpenoid 42-57 interleukin 6 Homo sapiens 12-16 34253436-9 2022 RESULTS: Pg-LPS or poly I:C significantly enhanced the production of IL-6 and PGE2 in MG63 cells. pg-lps 9-15 interleukin 6 Homo sapiens 69-73 34253436-10 2022 The additive/synergistic effects of Pg-LPS/poly I:C on production of IL-6 and PGE2 were evident. pg-lps 36-42 interleukin 6 Homo sapiens 69-73 34622233-0 2021 Blocking endogenous IL-6 impairs mobilization of free fatty acids during rest and exercise in lean and obese men. Fatty Acids, Nonesterified 49-65 interleukin 6 Homo sapiens 20-24 34293716-10 2021 Consistent with this model, the overexpression of IL-6 reversed the OGFRP1 knockdown-mediated reductions in docetaxel and paclitaxel IC50 values for these PC cells. Docetaxel 108-117 interleukin 6 Homo sapiens 50-54 21302967-3 2011 This sesquiterpenoid inhibited the secretion and expression of IL-6 in phorbol 12-myristate 13-acetate- and calcium ionophore A23187-stimulated human mast cells (HMC)-1. sesquiterpenoid 5-20 interleukin 6 Homo sapiens 63-67 34293716-11 2021 CONCLUSIONS: OGFRP1 can sequester miR-149-5p, thereby indirectly promoting IL-6 upregulation and thereby promoting chemoresistance in PC cells. mir-149-5p 34-44 interleukin 6 Homo sapiens 75-79 20645940-7 2011 CONCLUSION: Vitamin E and enoxaparin are able not only to prevent foetal wastage but also to balance IL-6 and VEGF placental levels, presenting a new potential therapeutic alternative for patients with recurrent abortion not associated with thrombophilias. Enoxaparin 26-36 interleukin 6 Homo sapiens 101-105 34356813-6 2021 Epiloliolide effectively increased the proliferation and migration of human periodontal ligament cells without cytotoxicity and suppressed the protein expression of proinflammatory mediators and cytokines, such as iNOS, COX-2, TNF-alpha, IL-6, and IL-1beta, by downregulating NLRP3 activated by PG-LPS. pg-lps 295-301 interleukin 6 Homo sapiens 238-242 34220507-8 2021 Significantly, our results showed that Myricetin has potent effect on bleomycin-induced pulmonary inflammation by inhibiting the infiltration of inflammatory cells and the secretion of inflammatory cytokines IL-6, IL-1alpha, TNF-alpha and IFN-gamma. Bleomycin 70-79 interleukin 6 Homo sapiens 208-212 34212125-3 2021 Objectives: This pilot study was designed to explore the hypotheses that 1) reduction in VAT is associated with increase in IL-6, and 2) that increases in urinary F2-isoprostanes are associated with increases in IL-6 and reduction in VAT. F2-Isoprostanes 163-178 interleukin 6 Homo sapiens 212-216 34209804-10 2021 In particular, the IL-6 levels were significantly lower in the LcS group than the placebo group after the ingestion period (p < 0.05). lcs 63-66 interleukin 6 Homo sapiens 19-23 34209804-11 2021 In conclusion, the daily consumption of LcS for 9 weeks appeared to relieve constipation and improve the potentially depressive symptoms in patients with depression and significantly decrease the IL-6 levels. lcs 40-43 interleukin 6 Homo sapiens 196-200 34206644-6 2021 (3) Results: In comparison to normoglycaemic counterparts (n = 676, 89.2%), an increase in IL-6 concentrations, in individuals with hyperglycaemia (HbA1c >= 6.5%) (n = 82, 10.8%) (p = 0.04), was significantly associated with a flatter DCS. Cycloserine 235-238 interleukin 6 Homo sapiens 91-95 34206644-9 2021 (4) Conclusions: In our sample, the relation between flatter DCS and hyperglycaemia was partly explained by IL-6 levels. Cycloserine 61-64 interleukin 6 Homo sapiens 108-112 34234397-0 2021 Molecular docking analysis of stachydrine and sakuranetin with IL-6 and TNF-alpha in the context of inflammation. sakuranetin 46-57 interleukin 6 Homo sapiens 63-67 20946124-9 2011 BK-induced release of IL-6, but not of IL-8, was partially inhibited by indomethacin (10 microM) and nordihydroguaiaretic acid (10 microM). Masoprocol 101-126 interleukin 6 Homo sapiens 22-26 34234397-2 2021 Therefore, it is of interest to document the anti-inflammatory activity of Stachydrine and Sakuranetin against the inflammatory target proteins IL-6 and TNF-alpha by using molecular docking analysis. sakuranetin 91-102 interleukin 6 Homo sapiens 144-148 34497749-13 2021 Quercetin and Luteolin were verified to have good binding capability with the hub potential targets IL6, MAPK1, AKT1 through molecular docking. Quercetin 0-9 interleukin 6 Homo sapiens 100-103 34099967-10 2021 To date, evidence from clinical trials supports the use of IL-6 blockade for desensitization and treatment of AMR in kidney transplant recipients. amr 110-113 interleukin 6 Homo sapiens 59-63 34084299-7 2021 Patients with abnormal DMSA had significantly higher serum IL-6 and IL-8 compared with those with normal DMSA scan (187.1 +- 113.1 ng/mL vs. 396.1 +- 246.0 ng/mL, P = 0.005; and 165 +- 76.1 ng/mLvs. Succimer 23-27 interleukin 6 Homo sapiens 59-63 20739465-10 2011 Hypertonicity-induced increases in IL-6 and IL-8 releases were suppressed by exposure to capsazepine, AG 1478, ERK inhibitor PD 98059, p38 inhibitor SB 203580, or NF-kappaB inhibitor PDTC. capsazepine 89-100 interleukin 6 Homo sapiens 35-39 20554188-5 2011 Icariin also inhibited LPS-induced bone resorption and interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) expression. icariin 0-7 interleukin 6 Homo sapiens 55-68 34981474-3 2021 The present study investigated the effects of curcumin (CUR) and difluorinated curcumin (CDF) on Candida species. difluorinated curcumin 65-87 interleukin 6 Homo sapiens 89-92 35352237-6 2022 Furthermore, quercetin decreased the pro-inflammatory cell environment upon LPS-induced endothelial activation, in terms of tumor necrosis factor- alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-8 (IL-8), and sVCAM-1 expression. Quercetin 13-22 interleukin 6 Homo sapiens 166-179 35352237-6 2022 Furthermore, quercetin decreased the pro-inflammatory cell environment upon LPS-induced endothelial activation, in terms of tumor necrosis factor- alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-8 (IL-8), and sVCAM-1 expression. Quercetin 13-22 interleukin 6 Homo sapiens 181-185 35219165-10 2022 Furthermore, PR-957 treatment or CD4+ T cell depletion in chronic liver injury alleviated liver fibrosis and reduced inflammation, as indicated by the downregulation of inflammatory response markers (F4/80, IL-1, IL-6 and IL-18). PR-957 13-19 interleukin 6 Homo sapiens 213-217 20554188-5 2011 Icariin also inhibited LPS-induced bone resorption and interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) expression. icariin 0-7 interleukin 6 Homo sapiens 70-74 35604131-5 2022 In addition, dramatic decreases in gamma interferon and interleukin-6 cytokine levels were observed in the RSA group. rabbit sperm membrane autoantigen 107-110 interleukin 6 Homo sapiens 56-69 35440370-6 2022 The addition of amoxicillin to clarithromycin resulted in an increase in CD8+ IL-6 (p = 0.010), decrease in CD8+ (p = 0.014) and CD4+ (p = 0.022) TNF-alpha, and decrease in CD8+ IFN-alpha (p = 0.038). Amoxicillin 16-27 interleukin 6 Homo sapiens 78-82 22024524-3 2011 In this study, we investigated the association of serum IL-6 levels with outcomes of pegylated interferon (PEG-IFN) plus ribavirin (RBV) combination therapy. Ribavirin 121-130 interleukin 6 Homo sapiens 56-60 35063828-0 2022 Peptide nanotubes/self-assembled polydopamine molecularly imprinted biochip for the impedimetric detection of human Interleukin-6. polydopamine 33-45 interleukin 6 Homo sapiens 116-129 35063828-1 2022 In the study, an impedimetric biochip was designed with molecularly imprinted polydopamine (MIP(pDa)) on peptide nanotube (PNT) functionalized screen printed electrodes (SPEs) and adopted first time as a support matrix to construct the electrochemical sensor for the determination of interleukin 6 (IL-6). polydopamine 78-90 interleukin 6 Homo sapiens 284-297 35063828-1 2022 In the study, an impedimetric biochip was designed with molecularly imprinted polydopamine (MIP(pDa)) on peptide nanotube (PNT) functionalized screen printed electrodes (SPEs) and adopted first time as a support matrix to construct the electrochemical sensor for the determination of interleukin 6 (IL-6). polydopamine 78-90 interleukin 6 Homo sapiens 299-303 35366469-13 2022 The binding of five active ingredients originated from Gancao-Banxia to IL-6-STAT3 was verified by molecular docking, namely quercetin, coniferin, licochalcone a, Licoagrocarpin and (3S,6S)-3-(benzyl)-6-(4-hydroxybenzyl)piperazine-2,5-quinone, maximizing therapeutic efficacy. Quercetin 125-134 interleukin 6 Homo sapiens 72-76 35453017-10 2022 (3) based on canonical correlation analysis, the exposure to p-cymene, benzene, and styrene in PM2.5 was most likely associated with the toxicity effects (CAT, IL-6, and TNF-alpha), which in turn caused the observed toxicity. 4-cymene 61-69 interleukin 6 Homo sapiens 160-164 35134851-10 2022 Sulprostone intensified the mRNA levels of IL-6 together with interferon-gamma (IFN-gamma), while L-798,106 stimulated the mRNA expression of IL-10 and Arg-1 in a dose-dependent manner. Leucine 98-99 interleukin 6 Homo sapiens 43-47 22024524-3 2011 In this study, we investigated the association of serum IL-6 levels with outcomes of pegylated interferon (PEG-IFN) plus ribavirin (RBV) combination therapy. Ribavirin 132-135 interleukin 6 Homo sapiens 56-60 35405286-0 2022 Toll-like receptors in the mechanism of tributyltin-induced production of pro-inflammatory cytokines, IL-1beta and IL-6. tributyltin 40-51 interleukin 6 Homo sapiens 115-119 35247778-12 2022 Additionally, 7-d-GDN remarkably down-regulated MMP-1/3/9/13 in RASFs, IL-6 and IL-33 in MH7A cells. 7-d-gdn 14-21 interleukin 6 Homo sapiens 71-75 22024524-8 2011 In male patients with SVR, serum IL-6 levels decreased significantly at 4 weeks of treatment (P=0.029) and remained significantly lower than those of non-SVR patients after 4, 8 and 12 weeks of PEG-IFN plus RBV therapy. Ribavirin 207-210 interleukin 6 Homo sapiens 33-37 35405286-3 2022 Previous studies have shown that exposure to TBT increases the cellular production (secretion plus intracellular levels) of the pro-inflammatory cytokines IL-1beta and IL-6 by peripheral blood mononuclear cells (PMBCs) and this increase requires MAPK activation. tributyltin 45-48 interleukin 6 Homo sapiens 168-172 22024524-9 2011 CONCLUSIONS: Our results suggest that baseline levels of IL-6, as well as their decrease during treatment, are correlated to outcomes of PEG-IFN plus RBV therapy in male patients. Ribavirin 150-153 interleukin 6 Homo sapiens 57-61 35405286-5 2022 The current study shows that selective inhibition of TLRs 4,1/2, and 8 diminishes the ability of TBT to stimulate IL-1beta and IL-6 production. tributyltin 97-100 interleukin 6 Homo sapiens 127-131 35405286-8 2022 These results provide an important advance in understanding TBT stimulation of IL-1beta and IL-6, which has the potential to cause chronic inflammation and its attendant pathologies. tributyltin 60-63 interleukin 6 Homo sapiens 92-96 35514301-10 2022 The results revealed that interleukin 1beta, bone morphogenetic protein 4, interleukin 6 and C-X-C motif chemokine ligand 12 had great potential to mediate the differential effects of VSCC-SCs and SCC-SCs on TAM infiltration. tam 208-211 interleukin 6 Homo sapiens 75-88 21498913-7 2011 In addition, the highest IL-6 quartile was an independent predictor of ST in those on clopidogrel (adjusted HR 7.70; 95%CI 1.97-30.13) but not in those who were off clopidogrel. Clopidogrel 86-97 interleukin 6 Homo sapiens 25-29 35574984-15 2022 IL6 was positively correlated with WZ3105 and MPS-1-IN-1 in the cancer therapeutics response portal database. wz3105 35-41 interleukin 6 Homo sapiens 0-3 35562770-10 2022 CONCLUSION: FSH/FSHR could negatively regulate the immunosuppressive function of DMSCs by reducing secretion of IL-6 levels through MyD88 pathways, but upstream and downstream signalling pathways require further validation. doxycycline fosfatex 81-86 interleukin 6 Homo sapiens 112-116 35175765-2 2022 For the in vitro studies, the trans-4-hydroxy-l-proline methyl ester derivatives (1f and 2f) were consistently effective in inhibiting NO, IL-6, and TNF-alpha secretion, as well as inhibition of NF-kappaB activation, in RAW cells stimulated by LPS. (2S,4R)-Methyl 4-hydroxypyrrolidine-2-carboxylate 30-68 interleukin 6 Homo sapiens 139-143 35625671-9 2022 The expression levels of CD33+ leukocytes and circulating IL-6 were higher (p < 0.05) among patients with arterial oxygen partial pressure-to-fractional inspired oxygen (PaO2/FiO2) ratios below 13.3 kPa compared to in the remaining patients. pao2 170-174 interleukin 6 Homo sapiens 58-62 21498913-8 2011 CONCLUSIONS: Highest IL-6 quartile was associated with ST, especially in clopidogrel users regardless of the time of ST, suggesting the involvement of inflammatory cytokines in ST. Clopidogrel 73-84 interleukin 6 Homo sapiens 21-25 35385549-10 2022 Based on the stability of the complexes, the high interactions rate of each ligand with the key residues of IL-6/IL-6Ralpha, and the low binding free energy calculation, two compounds ZINC83804241 and ZINC02997430, were identified as the most potential IL-6 inhibitor candidates. zinc83804241 184-196 interleukin 6 Homo sapiens 108-112 35385549-10 2022 Based on the stability of the complexes, the high interactions rate of each ligand with the key residues of IL-6/IL-6Ralpha, and the low binding free energy calculation, two compounds ZINC83804241 and ZINC02997430, were identified as the most potential IL-6 inhibitor candidates. zinc83804241 184-196 interleukin 6 Homo sapiens 253-257 21731444-4 2011 We observed no difference in cell viability as compared to control cultures, and an approximately 1.5-fold increase in IL-6 production upon incubation with 1% DSS. Dextran Sulfate 159-162 interleukin 6 Homo sapiens 119-123 35442463-17 2022 CONCLUSIONS: (1) Icariin, quercetin and luteolin may act on target proteins, including IL-6, ESR1, EGFR, MAPK8, VEGFA and CASP8, to participate in the regulation of the human cytomegalovirus infection pathway, the PI3K-Akt signaling pathway, the TNF signaling pathway and other signaling pathways in order to effectively treat CAD. icariin 17-24 interleukin 6 Homo sapiens 87-91 35368752-10 2022 Puerarin and paeoniflorin exerted anti-inflammatory effects by decreasing production of MDC/CCL22 and IL-6 in TI-treated HaCaT cells and VEGF production in SP/CRH-stimulated HMC-1 cells. peoniflorin 13-25 interleukin 6 Homo sapiens 102-106 35549778-7 2022 RESULTS: The expression level of IL-6 protein in GMECs was up-regulated in response to LPS treatment, and the secretion of TNF-alpha, the cell oxidative stress level and the Fe2+ ion content was robustly increased, which could be reversed by Fer-1 treatment. ammonium ferrous sulfate 174-178 interleukin 6 Homo sapiens 33-37 35549778-8 2022 Knockdown of IL-6 decreased cell oxidative stress level and inhibited ferroptosis in LPS-treated GMECs. gmecs 97-102 interleukin 6 Homo sapiens 13-17 35549778-10 2022 The NRF2 inhibitor Brusatol reversed the inhibitory effect of IL-6 shRNA on LPS-treated ferroptosis. brusatol 19-27 interleukin 6 Homo sapiens 62-66 35549778-11 2022 CONCLUSION: IL-6 protein is deubiquitinated by USP14 and upregulated in LPS-treated GMECs, further promoting ferroptosis and inflammation through the NRF2 signaling pathway. gmecs 84-89 interleukin 6 Homo sapiens 12-16 22096605-3 2011 However, the effects of PGD(2) and 15d-PGJ(2) in the absence or presence of PGE(2) on IL-6 synthesis in human chondrocytes have yet to be determined. 15d-pgj 35-42 interleukin 6 Homo sapiens 86-90 22096605-5 2011 METHODOLOGY/PRINCIPAL FINDINGS: Using the T/C-28a2 chondrocyte cell line as a model system, we report that exogenous PGE(2) and PGD(2)/15d-PGJ(2) exert antagonistic effects on IL-6 synthesis in human T/C-28a2 chondrocytes. Prostaglandins E 117-120 interleukin 6 Homo sapiens 176-180 35255173-7 2022 Then, the selected compound (diene 1) was evaluated as to its ability to inhibit the secretion of pro-inflammatory cytokines (IL-1beta, TNF-alpha, INF-gamma, MCP-1, and IL-6) and increase the production of anti-inflammatory cytokines (IL-13, IL-4, and IL-10). diene 29-34 interleukin 6 Homo sapiens 169-173 22096605-8 2011 PGD(2) or 15d-PGJ(2) concurrently downregulates TLR4 and upregulates caveolin-1, which in turn inhibit the PGE(2)-dependent ERK1/2, PI3-K and PKA activation, and ultimately with NF-kappaB-dependent IL-6 synthesis in chondrocytes. 15d-pgj 10-17 interleukin 6 Homo sapiens 198-202 35615020-5 2022 Using a leucine-rich repeat binding scaffold known as a "repebody" as the source of diversity in recognition against interleukin-6 (IL-6), we show that the "Epibin" approach introduced here effectively utilized structural modelling and docking to extract specificity information encoded in the repebody amino acid sequences and thereby successfully recapitulate IL-6 binding competition observed in immunoassays. Leucine 8-15 interleukin 6 Homo sapiens 117-130 35615020-5 2022 Using a leucine-rich repeat binding scaffold known as a "repebody" as the source of diversity in recognition against interleukin-6 (IL-6), we show that the "Epibin" approach introduced here effectively utilized structural modelling and docking to extract specificity information encoded in the repebody amino acid sequences and thereby successfully recapitulate IL-6 binding competition observed in immunoassays. Leucine 8-15 interleukin 6 Homo sapiens 132-136 22096605-9 2011 CONCLUSIONS/SIGNIFICANCE: We have delineated the signaling cascade by which PGE(2) and PGD(2)/15d-PGJ(2) exert opposing effects on IL-6 synthesis in human chondrocytes. Prostaglandins E 76-79 interleukin 6 Homo sapiens 131-135 22096605-9 2011 CONCLUSIONS/SIGNIFICANCE: We have delineated the signaling cascade by which PGE(2) and PGD(2)/15d-PGJ(2) exert opposing effects on IL-6 synthesis in human chondrocytes. 15d-pgj 94-101 interleukin 6 Homo sapiens 131-135 35197546-0 2022 Ibrutinib reverses IL-6-induced osimertinib resistance through inhibition of Laminin alpha5/FAK signaling. osimertinib 32-43 interleukin 6 Homo sapiens 19-23 22039452-3 2011 Quercetin significantly attenuated intercellular adhesion molecule-1 (ICAM-1), interleukin (IL) -6, IL-8, and cyclooxygenase (COX) -2 mRNA expression, and inhibited IL-1beta-induced increases in ICAM-1, IL-6, and IL-8 mRNA. Quercetin 0-9 interleukin 6 Homo sapiens 79-98 35197546-3 2022 Here we show that clinically, plasma IL-6 level predicts osimertinib efficacy in EGFR mutant NSCLC patients. osimertinib 57-68 interleukin 6 Homo sapiens 37-41 35197546-4 2022 Highly increased IL-6 levels are found in patients with acquired resistance to osimertinib. osimertinib 79-90 interleukin 6 Homo sapiens 17-21 35197546-5 2022 Addition of IL-6 or exogenous overexpression of IL-6 directly induces osimertinib resistance. osimertinib 70-81 interleukin 6 Homo sapiens 12-16 35197546-5 2022 Addition of IL-6 or exogenous overexpression of IL-6 directly induces osimertinib resistance. osimertinib 70-81 interleukin 6 Homo sapiens 48-52 35343796-7 2022 Moreover, Probio-M8 treatment was more conducive to alleviating depression and anxiety in patients (P < 0.0001 versus the placebo group, day 180), with significantly lower serum levels of interleukin-6 and low-density lipoprotein cholesterol (P < 0.005 and P < 0.001, respectively). probio-m8 10-19 interleukin 6 Homo sapiens 188-201 35397768-4 2022 To develop a population pharmacokinetic model for midazolam in adult intensive care unit patients infected with COVID-19 and to assess the effect of inflammation, reflected by IL-6, on the pharmacokinetics of midazolam. Midazolam 209-218 interleukin 6 Homo sapiens 176-180 35397768-12 2022 Midazolam clearance was reduced by increased IL-6 and IL-6 explained more of the variability within our patients than CRP. Midazolam 0-9 interleukin 6 Homo sapiens 45-49 35397768-12 2022 Midazolam clearance was reduced by increased IL-6 and IL-6 explained more of the variability within our patients than CRP. Midazolam 0-9 interleukin 6 Homo sapiens 54-58 35197546-7 2022 Next, using a large-scale compound screening, we identify ibrutinib as a potent inhibitor of IL-6 and Laminin alpha5/FAK signaling, which shows synergy with osimertinib in osimertinib-resistant cells with high IL-6 levels, but not in those with low IL-6 levels. osimertinib 157-168 interleukin 6 Homo sapiens 93-97 35197546-7 2022 Next, using a large-scale compound screening, we identify ibrutinib as a potent inhibitor of IL-6 and Laminin alpha5/FAK signaling, which shows synergy with osimertinib in osimertinib-resistant cells with high IL-6 levels, but not in those with low IL-6 levels. osimertinib 157-168 interleukin 6 Homo sapiens 210-214 35197546-7 2022 Next, using a large-scale compound screening, we identify ibrutinib as a potent inhibitor of IL-6 and Laminin alpha5/FAK signaling, which shows synergy with osimertinib in osimertinib-resistant cells with high IL-6 levels, but not in those with low IL-6 levels. osimertinib 157-168 interleukin 6 Homo sapiens 249-253 35197546-9 2022 Taken together, we conclude that Laminin alpha5/FAK signaling is responsible for IL-6-induced osimertinib resistance, which could be reversed by combination of ibrutinib and osimertinib. osimertinib 94-105 interleukin 6 Homo sapiens 81-85 35397768-13 2022 The midazolam clearance was reduced by 24% (6.7-5.1 L/h) when IL-6 increases from population median 116 to 300 pg/mL. Midazolam 4-13 interleukin 6 Homo sapiens 62-66 35397768-14 2022 CONCLUSIONS: Inflammation, reflected by high IL-6, reduces midazolam clearance in critically ill patients with COVID-19. Midazolam 59-68 interleukin 6 Homo sapiens 45-49 22039452-3 2011 Quercetin significantly attenuated intercellular adhesion molecule-1 (ICAM-1), interleukin (IL) -6, IL-8, and cyclooxygenase (COX) -2 mRNA expression, and inhibited IL-1beta-induced increases in ICAM-1, IL-6, and IL-8 mRNA. Quercetin 0-9 interleukin 6 Homo sapiens 203-207 35432570-10 2022 The molecular docking results showed effective ingredients (quercetin, kaempferol, and 7-methoxy-2-methyl isoflavone) have good docking results with targets (IL-6, PTGS2, and TNF). Quercetin 60-69 interleukin 6 Homo sapiens 158-162 20943792-7 2010 RESULTS: Quercetin, and to a lesser extent trans-RSV, attenuated the TNF-alpha-induced expression of inflammatory genes such as interleukin (IL)-6, IL-1beta, IL-8, and monocyte chemoattractant protein-1 (MCP-1) and the secretion of IL-6, IL-8, and MCP-1. Quercetin 9-18 interleukin 6 Homo sapiens 232-236 35432524-0 2022 IL-6 Promotes Hepatocellular Carcinoma Invasion by Releasing Exosomal miR-133a-3p. mir-133a 70-78 interleukin 6 Homo sapiens 0-4 35043384-10 2022 In the context of acute viral infection (COVID-19), IL-6 may partially replace ACTH as a stimulus of the glucocorticoid-secreting adrenal zona-fasciculata without influencing the secretion of DHEA and aldosterone. Aldosterone 201-212 interleukin 6 Homo sapiens 52-56 21121809-10 2010 The aqueous levels of IL-6 were positively correlated with TMV and CSMT in eyes with DR. tmv 59-62 interleukin 6 Homo sapiens 22-26 35048965-0 2022 Retraction: Cajanonic acid A regulates the ratio of Th17/Treg via inhibition of expression of IL-6 and TGF-beta in insulin-resistant HepG2 cells. treg 57-61 interleukin 6 Homo sapiens 94-98 35100519-7 2022 In vitro, TMAO significantly increased the expression of Kng1, Cxcl1, Cxcl2, CxcL6 and Il6 in bone marrow derived macrophage. trimethyloxamine 10-14 interleukin 6 Homo sapiens 87-90 35442463-17 2022 CONCLUSIONS: (1) Icariin, quercetin and luteolin may act on target proteins, including IL-6, ESR1, EGFR, MAPK8, VEGFA and CASP8, to participate in the regulation of the human cytomegalovirus infection pathway, the PI3K-Akt signaling pathway, the TNF signaling pathway and other signaling pathways in order to effectively treat CAD. Quercetin 26-35 interleukin 6 Homo sapiens 87-91 34967278-12 2022 Furthermore, PRRX1 deletion decreased TNF-alpha, IL-1beta and IL-6 levels in the DSS-challenged NCM460 cells, which were subjected to MMP13 overexpression. Dextran Sulfate 81-84 interleukin 6 Homo sapiens 62-66 21042414-1 2010 5-Androstene-3beta,7beta,17beta-triol (beta-AET), an active metabolite of dehydroepiandrosterone (DHEA), reversed glucocorticoid (GC)-induced suppression of IL-6, IL-8 and osteoprotegerin production by human osteoblast-like MG-63 cells and promoted osteoblast differentiation of human mesenchymal stem cells (MSCs). 5-androstene-3beta 0-18 interleukin 6 Homo sapiens 157-161 35239010-1 2022 PURPOSE: To investigate the changes in vitreous inflammatory and angiogenic cytokine levels, primarily interleukin-(IL)-6, following intravitreal injection of the 0.19 mg fluocinolone acetonide (FAc, ILUVIEN ) implant in patients with diabetic macular edema. Fluocinolone Acetonide 171-193 interleukin 6 Homo sapiens 103-121 35239010-9 2022 Significant changes (p < 0.05 versus baseline) were observed in the expression of IL-6, IP-10, MCP-1, and CD54 following the administration of fluocinolone acetonide implant. Fluocinolone Acetonide 143-165 interleukin 6 Homo sapiens 82-86 20309792-9 2010 Molecular docking studies showed that the complementarity of prenylated flavonoids with the hydrophobic MD-2 pocket (indicating goodness of fit) directly predicted their relative ability to inhibit MCP-1 and IL-6 production. Flavonoids 72-82 interleukin 6 Homo sapiens 208-212 35141934-12 2022 Finally, AA attenuated LPS- or LTA-induced cytokine production of IL-1ss, IL-6, IL-8, and TNF. lipoteichoic acid 31-34 interleukin 6 Homo sapiens 74-78 20822542-6 2010 The decreases from baseline to week 52 in IL-6, ICAM-1, VEGF, MMP-3, and CRP and increases in IL-12p40 levels were larger in patients receiving placebo infliximab 6 mg/kg +MTX versus infliximab 3 mg/kg + MTX treatment. Methotrexate 172-175 interleukin 6 Homo sapiens 42-46 35216054-6 2022 Furthermore, the anti-inflammatory action of sulforaphane-loaded membrane vesicles was demonstrated, as a decrease in interleukins crucial for the development of inflammation, such as TNF-alpha, IL-1beta and IL-6, was observed. sulforaphane 45-57 interleukin 6 Homo sapiens 208-212 35062054-6 2022 The cumulative evidence synthesized in the current review suggests that, traditional therapies which include thiazolidinediones, statins and some calcium channel blockers can be useful in the primary prevention of atherosclerosis by inhibiting the formation of monocyte-derived microparticles, and pro-inflammatory cytokines such as IL-6, TNF-alpha, MCP-1, and NF-kappaB in patients with T2D. Thiazolidinediones 109-127 interleukin 6 Homo sapiens 333-337 20378717-4 2010 We found that beta-escin, a pentacyclic triterpenoid, inhibited both constitutive and interleukin-6-inducible STAT3 activation in a dose- and time-dependent manner in HCC cells. Escin 14-24 interleukin 6 Homo sapiens 86-99 35064144-10 2022 Then, in vitro experiments showed that quercetin interfered with Th1/Th2 balance by acting on IL-6 and IFN-gamma to modulate the immune system in treating OLP. Quercetin 39-48 interleukin 6 Homo sapiens 94-98 20109438-0 2010 Lipoteichoic acid enhances IL-6 production in human synovial fibroblasts via TLR2 receptor, PKCdelta and c-Src dependent pathways. lipoteichoic acid 0-17 interleukin 6 Homo sapiens 27-31 35173877-1 2022 OBJECTIVES: This prospective study aimed to explore the effects of various doses of rosuvastatin on the hemodynamic changes, highly sensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6) levels in elderly patients with unstable angina pectoris. Rosuvastatin Calcium 84-96 interleukin 6 Homo sapiens 174-187 35173877-1 2022 OBJECTIVES: This prospective study aimed to explore the effects of various doses of rosuvastatin on the hemodynamic changes, highly sensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6) levels in elderly patients with unstable angina pectoris. Rosuvastatin Calcium 84-96 interleukin 6 Homo sapiens 189-193 35054995-6 2022 The levels of IL-6 and IL-8 in HGFs were higher when the cells were treated with EBV than when treated with lipopolysaccharide and lipoteichoic acid. lipoteichoic acid 131-148 interleukin 6 Homo sapiens 14-18 20484173-3 2010 We estimated odds ratios and 95% confidence intervals (95% CI) to determine whether serum IL-6 was associated with colorectal adenoma recurrence and flavonol intake and thus may serve as a risk indicator and as a response indicator to dietary flavonols. 3-hydroxyflavone 149-157 interleukin 6 Homo sapiens 90-94 20484173-5 2010 Intake of flavonols, especially of isorhamnetin, kaempferol, and quercetin, was inversely associated with serum IL-6 concentrations (highest versus lowest flavonol intake quartile, 1.80 versus 2.20 pg/mL) and high-risk (OR, 0.51; 95% CI, 0.26-0.98) and advanced adenoma recurrence (OR, 0.17; 95% CI, 0.06-0.50). Quercetin 65-74 interleukin 6 Homo sapiens 112-116 20484173-5 2010 Intake of flavonols, especially of isorhamnetin, kaempferol, and quercetin, was inversely associated with serum IL-6 concentrations (highest versus lowest flavonol intake quartile, 1.80 versus 2.20 pg/mL) and high-risk (OR, 0.51; 95% CI, 0.26-0.98) and advanced adenoma recurrence (OR, 0.17; 95% CI, 0.06-0.50). 3-hydroxyflavone 10-18 interleukin 6 Homo sapiens 112-116 20138155-7 2010 Formononetin dose-dependently decreased ALP, IL-6, VEGF, BMP-2, OCN and Col I in OA Obs, while markedly increased ALP, VEGF, BMP-2, OCN and Col I in normal Obs. formononetin 0-12 interleukin 6 Homo sapiens 45-49 35082667-11 2021 PIASCLEDINE-ExpASU was the most active of the tested ASU products in inhibiting nitric oxide, IL-6, and IL-8 production by chondrocytes. piascledine 0-11 interleukin 6 Homo sapiens 95-99 19962977-6 2010 In the second model, in blood of COPD-patients and healthy controls ex vivo pre-incubated with a physiological concentration of 1,7-dimethylxanthine (10microM), LPS-induced production of the cytokines IL-6 and TNF-alpha was significantly suppressed. 1,7-dimethylxanthine 128-148 interleukin 6 Homo sapiens 201-205 19939912-9 2010 By contrast, selective MR stimulation with aldosterone promoted the expression of IL6, plasminogen activator inhibitor 1, chemerin and leptin. Aldosterone 43-54 interleukin 6 Homo sapiens 82-85 20184247-6 2010 The patient received a humanized anti-interleukin-6 receptor antibody, (tocilizumab, 8 mg/kg), every 2 weeks for 3 years, during which time, his PaO2 level improved from 64.1 Torr to 83.4 Torr, vital capacity increased from 2.53 L to 3.95 L, and radiological abnormalities in the lungs gradually improved, suggesting that tocilizumab is effective for interstitial pneumonia in patients with multicentric Castleman disease. pao2 145-149 interleukin 6 Homo sapiens 38-51 21063104-7 2010 NOS inhibition by 4-ABH(4) was associated with increased LDH release, apoptosis and reduced IL-6 production in epithelial but not in endothelial monolayers. 4-abh 18-23 interleukin 6 Homo sapiens 92-96 19359044-8 2010 CONCLUSION: The findings of the present study indicate that increased level of IL-6 in depression could be directly related to symptoms of traumatic stress and somatoform dissociation. somatoform 160-170 interleukin 6 Homo sapiens 79-83 20391135-5 2010 In addition, the inflammatory cell response to PAH insult was examined through interleukin-1 (IL-1) alpha and interleukin-6 (IL-6) secretion. Polycyclic Aromatic Hydrocarbons 47-50 interleukin 6 Homo sapiens 110-123 20391135-5 2010 In addition, the inflammatory cell response to PAH insult was examined through interleukin-1 (IL-1) alpha and interleukin-6 (IL-6) secretion. Polycyclic Aromatic Hydrocarbons 47-50 interleukin 6 Homo sapiens 125-129 19766327-0 2009 Flavonoids, a prenatal prophylaxis via targeting JAK2/STAT3 signaling to oppose IL-6/MIA associated autism. Flavonoids 0-10 interleukin 6 Homo sapiens 80-84 20154512-7 2009 The TT +874 IFN-gamma and GG -174 IL-6 high producer-genotypes and the AA IL-10 low producergenotype were indeed more frequent in the ACP group (IFN-gamma: p=0.000 and IL-6: p=0.004). acp 134-137 interleukin 6 Homo sapiens 34-38 19447215-8 2009 In vitro studies showed that NSAIDs augmented IL-1beta- and IL-6-induced production of MMPs from human chondrocytes, while completely inhibiting the IL-1beta- and IL-6/sIL-6R-induced production of prostaglandin E(2) (PGE(2)). Prostaglandins E 217-220 interleukin 6 Homo sapiens 60-64 19447215-8 2009 In vitro studies showed that NSAIDs augmented IL-1beta- and IL-6-induced production of MMPs from human chondrocytes, while completely inhibiting the IL-1beta- and IL-6/sIL-6R-induced production of prostaglandin E(2) (PGE(2)). Prostaglandins E 217-220 interleukin 6 Homo sapiens 163-167 27789987-6 2009 Significant clinical benefit was demonstrated as well as reduced serum IL-6 levels with suppression of X-ray progression of disease in several clinical trials in which juvenile or adult RA patients were treated with tocilizumab monotherapy or tocilizumab plus methotrexate. Methotrexate 260-272 interleukin 6 Homo sapiens 71-75 19715447-5 2009 RESULTS/CONCLUSIONS: Tocilizumab, which blocks IL-6 binding to IL-6 receptor, used as monotherapy or in combination with methotrexate for RA therapy leads to significant clinical response and amelioration of joint damage, which is superior to methotrexate. Methotrexate 243-255 interleukin 6 Homo sapiens 47-51 19715447-5 2009 RESULTS/CONCLUSIONS: Tocilizumab, which blocks IL-6 binding to IL-6 receptor, used as monotherapy or in combination with methotrexate for RA therapy leads to significant clinical response and amelioration of joint damage, which is superior to methotrexate. Methotrexate 243-255 interleukin 6 Homo sapiens 63-67 19452524-9 2009 The associations between lutein and tocopherol and TP53 and KRAS2 mutations were modified by IL6 genotype. Tocopherols 36-46 interleukin 6 Homo sapiens 93-96 19745762-10 2009 Gangliosides suppressed infant bowel production of nitric oxide, leukotriene B4, prostaglandin E2, hydrogen peroxide, interleukin-1beta, interleukin-6, and interleukin-8 in response to LPS exposure and hypoxia. Gangliosides 0-12 interleukin 6 Homo sapiens 137-150 19687301-6 2009 Finally, the natural withanolide Withaferin A was found to repress IL-6 gene transcription in metastatic breast cancer cells upon dual inhibition of NF-kappaB and AP-1 Fra-1 transcription factors and silencing of IL-6 promoter chromatin accessibility. Withanolides 21-32 interleukin 6 Homo sapiens 67-71 19687301-6 2009 Finally, the natural withanolide Withaferin A was found to repress IL-6 gene transcription in metastatic breast cancer cells upon dual inhibition of NF-kappaB and AP-1 Fra-1 transcription factors and silencing of IL-6 promoter chromatin accessibility. Withanolides 21-32 interleukin 6 Homo sapiens 213-217 19687301-6 2009 Finally, the natural withanolide Withaferin A was found to repress IL-6 gene transcription in metastatic breast cancer cells upon dual inhibition of NF-kappaB and AP-1 Fra-1 transcription factors and silencing of IL-6 promoter chromatin accessibility. withaferin A 33-45 interleukin 6 Homo sapiens 67-71 19687301-6 2009 Finally, the natural withanolide Withaferin A was found to repress IL-6 gene transcription in metastatic breast cancer cells upon dual inhibition of NF-kappaB and AP-1 Fra-1 transcription factors and silencing of IL-6 promoter chromatin accessibility. withaferin A 33-45 interleukin 6 Homo sapiens 213-217 19698236-5 2009 It is concluded that cis-elements including T-Ag, PU.1, c-Ets, XPF-1, P2 alphaA, IL6-6RE and RAR may inhibit lrp16 expression and hormone or its inhibitor such as corticosteroid, tamoxifen, forskolin, phenylephrine, inflammatory factors such as IL6, IFNgamma and TNFalpha, and chemotherapeutics 5-fluorouracil may participate in the regulation of lrp16 gene expression in negative manner. Colforsin 190-199 interleukin 6 Homo sapiens 81-84 19698236-5 2009 It is concluded that cis-elements including T-Ag, PU.1, c-Ets, XPF-1, P2 alphaA, IL6-6RE and RAR may inhibit lrp16 expression and hormone or its inhibitor such as corticosteroid, tamoxifen, forskolin, phenylephrine, inflammatory factors such as IL6, IFNgamma and TNFalpha, and chemotherapeutics 5-fluorouracil may participate in the regulation of lrp16 gene expression in negative manner. Colforsin 190-199 interleukin 6 Homo sapiens 245-248 19698236-5 2009 It is concluded that cis-elements including T-Ag, PU.1, c-Ets, XPF-1, P2 alphaA, IL6-6RE and RAR may inhibit lrp16 expression and hormone or its inhibitor such as corticosteroid, tamoxifen, forskolin, phenylephrine, inflammatory factors such as IL6, IFNgamma and TNFalpha, and chemotherapeutics 5-fluorouracil may participate in the regulation of lrp16 gene expression in negative manner. Phenylephrine 201-214 interleukin 6 Homo sapiens 81-84 19490202-4 2009 DISCUSSION: Thiazolidinediones attenuate circulating levels of pro-inflammatory mediators in patients with type 2 diabetes, including C-reactive protein, interleukin-6, CD40L, monocyte chemoattractant protein-1 and metalloproteinase-9. Thiazolidinediones 12-30 interleukin 6 Homo sapiens 154-167 19187273-5 2009 We also found that IFN-gamma and IL-6 can induce BLyS expression on MM cells, while after the treatment of BAY11-7082, an IkB-alpha phosphorylation inhibitor, IFN-gamma induced up regulation of BLyS was completely inhibited, suggesting that nuclear factor kappaB (NF-kappaB) might be involved in the mechanism of the regulation of BLyS levels in response to cytokines. 3-(4-methylphenylsulfonyl)-2-propenenitrile 107-117 interleukin 6 Homo sapiens 33-37 19074641-7 2009 The JNK inhibitor SP-600125 blocked expression/secretion of IL-6 but only partially attenuated IL-8 expression. pyrazolanthrone 18-27 interleukin 6 Homo sapiens 60-64 19097821-7 2009 PMMA-CHDF performed for 3 days significantly reduced blood TNF-alpha level (183+/-159 pg/ml to 84+/-98 pg/ml, p<0.05) and also blood IL-6 level (1113+/-903 pg/ml to 402+/-411 pg/ml, p<0.01). pmma-chdf 0-9 interleukin 6 Homo sapiens 136-140 19327235-6 2009 RESULTS: Bortezomib proved to be a rapid (<24 hour) and potent inhibitor of the release of several NFkappaB-inducible cytokines (including TNF-alpha, IL-1Beta, IL-6 and IL-10) by activated T-cells from healthy volunteers and RA patients, regardless of their clinical responsiveness to methotrexate. Bortezomib 9-19 interleukin 6 Homo sapiens 163-167 18368033-4 2008 Glucocorticoid function was measured by glucocorticoid inhibition of lypopolysaccharide (LPS)-stimulated interleukin-6 (IL-6) levels. lypopolysaccharide 69-87 interleukin 6 Homo sapiens 105-118 18368033-4 2008 Glucocorticoid function was measured by glucocorticoid inhibition of lypopolysaccharide (LPS)-stimulated interleukin-6 (IL-6) levels. lypopolysaccharide 69-87 interleukin 6 Homo sapiens 120-124 19288903-15 2008 The effect of acupuncture is stronger than that of Isotretinoin Capsules in lowering serum IL-6 content and has fewer adverse effects. Isotretinoin 51-63 interleukin 6 Homo sapiens 91-95 18375611-1 2008 BACKGROUND: The guanidine to cytosine transition at position -174 nucleotides relative to the transcription start site in the interleukin (IL)-6 gene has been implicated as a genetic risk factor for the development of sepsis in very low birth weight (VLBW) infants. Cytosine 29-37 interleukin 6 Homo sapiens 126-144 18785973-4 2008 Serotype A induces also higher levels of interleukin (IL)-6 positive cells in neonates and infants compared with adults (serotype A; newborn 55.4%; infants 58.8% versus adults 49%; P < 0.05). serotype a 0-10 interleukin 6 Homo sapiens 41-59 18502099-6 2008 The importance of ERK and Sp1 in regulating IL-6 transcription was, furthermore, supported by the observation that treatment of U266 cells with U0126 or mithramycin, an antibiotic that prevents Sp1-DNA binding, abrogated constitutive IL-6 transcription. Plicamycin 153-164 interleukin 6 Homo sapiens 44-48 18502099-6 2008 The importance of ERK and Sp1 in regulating IL-6 transcription was, furthermore, supported by the observation that treatment of U266 cells with U0126 or mithramycin, an antibiotic that prevents Sp1-DNA binding, abrogated constitutive IL-6 transcription. Plicamycin 153-164 interleukin 6 Homo sapiens 234-238 18636164-0 2008 Stress-associated hormone, norepinephrine, increases proliferation and IL-6 levels of human pancreatic duct epithelial cells and can be inhibited by the dietary agent, sulforaphane. sulforaphane 168-180 interleukin 6 Homo sapiens 71-75 18636164-11 2008 Furthermore, sulforaphane also inhibits norepinephrine-mediated increase of the IL-6 levels but not VEGF levels. sulforaphane 13-25 interleukin 6 Homo sapiens 80-84 18636164-12 2008 Our study is the first to demonstrate that stress-associated hormone, norepinephrine, can increase the cell proliferation and IL-6 levels of human pancreatic duct epithelial cells, which can be inhibited by sulforaphane, a chemopreventive agent and a natural compound from the Cruciferous vegetables. sulforaphane 207-219 interleukin 6 Homo sapiens 126-130 18443271-5 2008 Mechanistic studies included immunoblotting of key apoptosis signaling proteins, analysis of p16 gene methylation status, and characterization of both the interleukin-6 and nuclear factor-kappaB signaling pathways following azacitidine treatment. Azacitidine 224-235 interleukin 6 Homo sapiens 155-168 18489792-3 2008 LXs, resolvins, protectins, and nitrolipids are endogenous anti-inflammatory lipid molecules that inhibit production of interleukin-6 (IL-6) and tumor necrosis factor- alpha (TNF-alpha), suppress free radical generation, enhance NO generation; and accelerate tissue repair. Lipoxins 0-3 interleukin 6 Homo sapiens 120-133 18489792-3 2008 LXs, resolvins, protectins, and nitrolipids are endogenous anti-inflammatory lipid molecules that inhibit production of interleukin-6 (IL-6) and tumor necrosis factor- alpha (TNF-alpha), suppress free radical generation, enhance NO generation; and accelerate tissue repair. Lipoxins 0-3 interleukin 6 Homo sapiens 135-139 18282234-7 2008 We found that increased levels of IL-6 from autologous monocytes in co-culture with MF-spheroids predicted recurrence with a hazard ratio (HR) of 1.5 [confidence interval (CI): 1.01-2.60; P = 0.05] and co-culture with BF-spheroids and monocytes predicted recurrence (HR = 4.17; CI: 1.54-11.29; P = 0.005). spheroids 87-96 interleukin 6 Homo sapiens 34-38 18205818-6 2008 Furthermore, forskolin also inhibited the LPS-induced levels of TNF-alpha, IL-12 p40, IL-23 p19 and IL-6, supporting the hypothesis that the effects of NE are mediated by cAMP. Colforsin 13-22 interleukin 6 Homo sapiens 100-104 18292576-5 2008 SP600125 reduced the expression of the CRP gene induced by IL-1 plus IL-6. pyrazolanthrone 0-8 interleukin 6 Homo sapiens 69-73 18239561-8 2008 Elevated (P < 0.001) concentrations of IL-6 following moderate (50% VO(2)) and high (75% VO(2)) intensity acute exercise were observed in both groups; however, concentrations of TNF-alpha were unchanged in response to acute exercise (P = 0.584). vo(2) 71-76 interleukin 6 Homo sapiens 42-46 18217720-22 2008 Madindolines were isolated from Streptomyces nitrosporeus K93-0711 by our program to discover new interleukin 6 (IL-6) modulators. madindolines 0-12 interleukin 6 Homo sapiens 113-117 17845838-1 2008 Previous studies that investigated the role of inflammation in the neurotoxicity of manganese (Mn) found that Mn enhanced the production of inflammogen (lipopolysaccharide; LPS)-induced proinflammatory cytokines such as IL-6 and TNF-alpha. Manganese 84-93 interleukin 6 Homo sapiens 220-224 18204329-8 2008 The PMMA-CHDF group showed significantly better outcomes, with significant improvements of the serum PAI-1, protein C, IL-6 and N-arachidonoylethanolamine (AEA) levels. Polymethyl Methacrylate 4-8 interleukin 6 Homo sapiens 119-123 18204329-8 2008 The PMMA-CHDF group showed significantly better outcomes, with significant improvements of the serum PAI-1, protein C, IL-6 and N-arachidonoylethanolamine (AEA) levels. chdf 9-13 interleukin 6 Homo sapiens 119-123 19012528-1 2008 BACKGROUND: Biogenic amine, adrenaline, noradrenaline, dopamine and 5-hydroxy-tryptamine (5-HT) levels are related to interleukin-6 (IL-6) plasma concentrations and endurance exercise. Amines 21-26 interleukin 6 Homo sapiens 118-131 19012528-1 2008 BACKGROUND: Biogenic amine, adrenaline, noradrenaline, dopamine and 5-hydroxy-tryptamine (5-HT) levels are related to interleukin-6 (IL-6) plasma concentrations and endurance exercise. Amines 21-26 interleukin 6 Homo sapiens 133-137 17848619-3 2007 We identify here leukemia inhibitory factor (LIF) and IL-6 as tumor microenvironmental factors that can promote TAM generation. tam 112-115 interleukin 6 Homo sapiens 54-58 17848619-9 2007 In addition to revealing a new tumor-escape mechanism associated with TAM generation via LIF and IL-6, these findings offer novel therapeutic perspectives to subvert TAM-induced immunosuppression and hence improve T-cell-based antitumor immunotherapy efficacy. tam 70-73 interleukin 6 Homo sapiens 97-101 18210237-8 2007 The inhibitory effects of costunolide on TNF-alpha and IL-6 production were abrogated by tin protoporphyrin, an HO inhibitor. tin protoporphyrin IX 89-107 interleukin 6 Homo sapiens 55-59 18082089-7 2007 Pharmacological treatment with either rosuvastatin or metformin lead to reductions in IL-6, TNFalpha, GSH and GPx levels and an increase in the SOD level, and there were significant interactions between the two treatment groups for these variables. Rosuvastatin Calcium 38-50 interleukin 6 Homo sapiens 86-90 17581928-3 2007 IL-6 increased the level of alpha-methyl-d-[(14)C]glucopyranoside (alpha-MG) uptake in time- and dose-dependent manners. alpha-mg 67-75 interleukin 6 Homo sapiens 0-4 17729422-8 2007 Compared with control group, LAM-DC group (0.5 mmol/L) secreted significantly more IL-12 (910 +/- 91.5 vs 268 +/- 34.3 pg/mL, P < 0.05), had lower levels of IL-6 in the culture supernatant (28 +/- 2.6 vs 55 +/- 7.36 pg/mL, P < 0.05), markedly enhanced the stimulatory capacity in the allogeneic mixed leukocyte reaction (MLR) (1.87 +/- 0.6 vs 1.24 +/- 0.51, P < 0.05). lam-dc 29-35 interleukin 6 Homo sapiens 160-164 17634198-8 2007 Treatment of the Caco-2 cells with live L. paracasei increased cellular levels of hsp70 and hsp27 and the potentiating effect on IL-6 production was inhibited by quercetin and by hsp70 or hsp27 siRNA. Quercetin 162-171 interleukin 6 Homo sapiens 129-133 17845274-8 2007 The sub-group of BDd patients showed an increase in IL-6 and TNF-alpha, as well as a decrease in IL-2 concentration. 7,7'-dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester 17-20 interleukin 6 Homo sapiens 52-56 17805088-7 2007 Coingestion of CAF/CHO significantly attenuated epinephrine (P<0.05) and IL-6 (P<0.05) responses that occurred after ingestion of CAF alone (CAF/PLA) and significantly attenuated the transient alterations in circulating leukocyte (P<0.05) and neutrophil (P<0.01) counts. cho 19-22 interleukin 6 Homo sapiens 76-80 17560936-7 2007 IL-6 protein expression could be antagonized with capsazepine. capsazepine 50-61 interleukin 6 Homo sapiens 0-4 26110364-8 2007 Fibroblasts are also stimulated by DDHAM to secrete key proinflammatory(IL-1 and IL-6) and chemotactic cytokines or chemokines (proand IL-8) involved in regulating and enhancing wound repair processes. ddham 35-40 interleukin 6 Homo sapiens 81-85 17466485-0 2007 Simvastatin and fluvastatin reduce interleukin-6 and interleukin-8 lipopolysaccharide (LPS) stimulated production by isolated human monocytes from chronic kidney disease patients. Fluvastatin 16-27 interleukin 6 Homo sapiens 35-48 16572284-6 2007 Multiple studies have suggested that MCD and rheumatoid arthritis are associated with overexpression of the growth-promoting cytokine interleukin-6 (IL-6), and that MTX downregulates the production of this cytokine in vivo. Methotrexate 165-168 interleukin 6 Homo sapiens 134-147 16572284-6 2007 Multiple studies have suggested that MCD and rheumatoid arthritis are associated with overexpression of the growth-promoting cytokine interleukin-6 (IL-6), and that MTX downregulates the production of this cytokine in vivo. Methotrexate 165-168 interleukin 6 Homo sapiens 149-153 17517790-3 2007 In this report, we demonstrated the development of a high-level expression system to produce a 78-kDa human fusion protein IL-6/TPO (named ZH646). zh646 139-144 interleukin 6 Homo sapiens 123-127 17517790-8 2007 These results suggested that ZH646 is a novel protein, and its activities are much stronger than that of TPO or IL-6 alone. zh646 29-34 interleukin 6 Homo sapiens 112-116 17449045-3 2007 Binding of IL-6 in the presence of ammonium sulfate (AS) was tested using low- and high-substituted phenyl-sepharose. Ammonium Sulfate 35-51 interleukin 6 Homo sapiens 11-15 17449045-3 2007 Binding of IL-6 in the presence of ammonium sulfate (AS) was tested using low- and high-substituted phenyl-sepharose. Ammonium Sulfate 53-55 interleukin 6 Homo sapiens 11-15 17513621-7 2007 The increase in serum IL-6 levels was significantly attenuated in the morphine group compared to the fentanyl group at 3 and 24 h post-CPB (P < 0.05). Fentanyl 101-109 interleukin 6 Homo sapiens 22-26 17580130-8 2007 Moreover, the concentrations of IL-6 and IL-10 correlated negatively with hypoxanthine concentrations, and the concentrations of IL-4 also correlated negatively with Xan concentrations. Hypoxanthine 74-86 interleukin 6 Homo sapiens 32-36 17395587-6 2007 The induction of IL-6 by salmeterol was dependent upon the beta(2) receptor and could also be induced by cAMP or cAMP-elevating agents forskolin and rolipram. Colforsin 135-144 interleukin 6 Homo sapiens 17-21 17461989-6 2007 Depletion of the PPARdelta receptor, but not of PPARalpha or gamma, attenuated the suppressive effect of GW501516 on interleukin-6-induced alpha1-antichymotrypsin mRNA expression, indicating that PPARdelta specifically mediated this effect. GW 501516 105-113 interleukin 6 Homo sapiens 117-130 17461989-8 2007 Overexpression of PPARdelta enhanced the suppressive effect of GW501516 on STAT3-activated transcriptional activity of the alpha1-antichymotrypsin promoter, while GW501516 suppressed interleukin-6-induced binding of this transcription factor to this promoter. GW 501516 163-171 interleukin 6 Homo sapiens 183-196 17266043-8 2007 We also showed that IL-6-induced AKR1C1/1C2 expression and drug resistance were inhibited by wogonin and chrysin, which are major flavonoids in Scutellaria baicalensis, a widely used traditional Chinese and Japanese medicine. Flavonoids 130-140 interleukin 6 Homo sapiens 20-24 17289797-7 2007 Furthermore, pretreatment of cells with Bay 11-7082 substantially inhibited the secretion of TNF-alpha, IL-1beta, and IL-6 induced by H2S. 3-(4-methylphenylsulfonyl)-2-propenenitrile 40-51 interleukin 6 Homo sapiens 118-122 17306835-7 2007 Capsaicin (10 nM-10 muM) induced production of IL-6 from HNECs and NHBE cells and this effect was inhibited by pretreatment with capsazepine. capsazepine 129-140 interleukin 6 Homo sapiens 47-51 17374166-0 2007 The Interleukin-6 inflammation pathway from cholesterol to aging--role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases. Diphosphonates 83-98 interleukin 6 Homo sapiens 4-17 16765356-7 2007 Furthermore, lysophosphatidylcholine (lysoPC), a product of Lp-PLA2 activity, induced an increase in several inflammatory cytokines (IL-1beta, IL-6, TNF-alpha) in a concentration-dependent manner. Lysophosphatidylcholines 13-36 interleukin 6 Homo sapiens 143-147 16765356-7 2007 Furthermore, lysophosphatidylcholine (lysoPC), a product of Lp-PLA2 activity, induced an increase in several inflammatory cytokines (IL-1beta, IL-6, TNF-alpha) in a concentration-dependent manner. Lysophosphatidylcholines 38-44 interleukin 6 Homo sapiens 143-147 17335379-1 2007 BACKGROUND: In previous work, the cyclooxygenase-2 inhibitor NS-398 inhibited interleukin (IL)-1beta-stimulated prostaglandin E(2) (PGE(2)) production almost completely while partially inhibiting IL-6 production in aggressive periodontitis (AgP) human gingival fibroblasts. Prostaglandins E 132-135 interleukin 6 Homo sapiens 196-200 17335379-2 2007 PGE(2) and the transcription factor nuclear factor-kappa B (NF-kappaB) regulate IL-1beta-stimulated IL-6 production. Prostaglandins E 0-3 interleukin 6 Homo sapiens 100-104 17134824-12 2007 IL-6 was down-regulated in all three cell lines by all-trans-retinoic acid treatment. 2-octenal 55-61 interleukin 6 Homo sapiens 0-4 17673806-9 2007 Because adenylate cyclase activity is allosterically enhanced when it binds prostaglandin E, the latter increases Il-6. Prostaglandins E 76-91 interleukin 6 Homo sapiens 114-118 17191106-4 2006 In this report we show that quercetin, a natural compound able to act as an inhibitor of mast cell secretion, causes a decrease in the release of tryptase and IL-6 and the down-regulation of histidine decarboxylase (HDC) mRNA from human mast cell (HMC)-1 cells. Quercetin 28-37 interleukin 6 Homo sapiens 159-163 17191106-5 2006 As quercetin dramatically inhibits mast cell tryptase and IL-6 release and HDC mRNA transcription by HMC-1 cell line, these results nominate quercetin as a therapeutical compound in association with other therapeutical molecules for neurological diseases mediated by mast cell degranulation. Quercetin 3-12 interleukin 6 Homo sapiens 58-62 17191106-5 2006 As quercetin dramatically inhibits mast cell tryptase and IL-6 release and HDC mRNA transcription by HMC-1 cell line, these results nominate quercetin as a therapeutical compound in association with other therapeutical molecules for neurological diseases mediated by mast cell degranulation. Quercetin 141-150 interleukin 6 Homo sapiens 58-62 17105880-6 2006 A significant decrease in NT-proBNP (p<0.01), high-sensitivity CRP (p<0.01) and plasma IL6 (p = 0.05) was also observed in the levosimendan group, whereas these markers remained unchanged in the placebo group; similar changes were observed after each drug infusion. Simendan 133-145 interleukin 6 Homo sapiens 93-96 17089010-4 2006 As detected by means of immunocytochemistry, Western immunoblotting, and ELISA assays, the intracellular levels and secretion rates of IL-6 were drastically curtailed in the CW-DMEM-incubated keratinocytes and in their cell-conditioned media. dmem 177-181 interleukin 6 Homo sapiens 135-139 17089010-5 2006 A nearly maximal inhibition of IL-6 release had already been induced by a CW fraction in the DMEM as low as 25%. dmem 93-97 interleukin 6 Homo sapiens 31-35 17089061-12 2006 DSS induced the weak release of IL-8, IL-6, and TGF-beta1. Dextran Sulfate 0-3 interleukin 6 Homo sapiens 38-42 16790433-3 2006 COX-2-derived PGE(2) induces interleukin-6 production through activation of EP(4) receptor and subsequent phosphorylation of gp130/Stat3 in human cholangiocarcinoma cells. Prostaglandins E 14-17 interleukin 6 Homo sapiens 29-42 16890779-5 2006 RESULTS: The synthetic heterocycle, chemically related to adenine with substitution in positions 2-, 8-, and 9- (SA-2), but not its related derivative lacking 2- and 8- substitutions, stimulated the production of high amounts of IL-12, IL-10, TNF-alpha, and IL-6 by CD14(+) cells and IFN-alpha and CXCL10 by blood dendritic cell antigen (BDCA)-4(+) plasmacytoid dendritic cells. Adenine 58-65 interleukin 6 Homo sapiens 258-262 16784930-7 2006 Plasma N-terminal-pro-B-type natriuretic peptide, tumor necrosis factor-alpha, and soluble Fas ligand levels were significantly decreased only in the levosimendan group (from 1,900 +/- 223 to 1,378 +/- 170 pg/ml, 13.4 +/- 1.0 to 12.3 +/- 1.2 pg/ml, and 68.2 +/- 3.7 to 59.8 +/- 3.6 pg/ml, respectively; p <0.05 for all); interleukin-6 was also borderline reduced (p = 0.051). Simendan 150-162 interleukin 6 Homo sapiens 324-337 16690359-12 2006 The peak IL-6 concentration after CG7870 treatment was associated with a transient, asymptomatic decrease in blood pressure. cg7870 34-40 interleukin 6 Homo sapiens 9-13 16547804-0 2006 Histamine and PGE(2) stimulate the production of interleukins -6 and -8 by human articular chondrocytes in vitro. Prostaglandins E 14-17 interleukin 6 Homo sapiens 49-71 16595469-10 2006 RESULTS: Both titanium and polymethylmethacrylate particles potently inhibited interleukin-6-induced STAT3 activation in human osteoclast precursor cells. Polymethyl Methacrylate 27-49 interleukin 6 Homo sapiens 79-92 16595469-11 2006 Inhibition of p38 mitogen-activated protein kinase, which is activated by titanium and polymethylmethacrylate, reversed the inhibitory effects of these particles on interleukin-6 signaling, whereas inhibition of ERK and JNK mitogen-activated protein kinases (which are also activated by both types of wear debris) had no effect. Polymethyl Methacrylate 87-109 interleukin 6 Homo sapiens 165-178 16595469-12 2006 Titanium and polymethylmethacrylate also both induced expression of SOCS3, an inhibitor of interleukin-6 signaling. Polymethyl Methacrylate 13-35 interleukin 6 Homo sapiens 91-104 16220550-6 2006 In the present study, we report that tetracycline and minocycline dose-dependently reduce TNF-alpha and IL-6 release by adult human microglia upon stimulation with a combination of Abeta, SAP, and C1q. Minocycline 54-65 interleukin 6 Homo sapiens 104-108 16584593-4 2006 The results indicated that after treatment with PS-341 the expressions of IL-6, IL-1beta and SCF of MSCs decreased markedly, especially that of IL-1beta, compared with control (P < 0.05, P < 0.01, P < 0.05, respectively). Bortezomib 48-54 interleukin 6 Homo sapiens 74-78 16584593-6 2006 It is concluded that proteasome inhibitor PS-341 downregulated the expressions of IL-6, IL-1beta and SCF of MSCs in patients with MM. Bortezomib 42-48 interleukin 6 Homo sapiens 82-86 16397231-7 2006 Bortezomib triggered a dose-dependent inhibition of vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) secretion by the MMECs, and reverse transcriptase-PCR confirmed drug-related down-regulation of VEGF, IL-6, insulin-like growth factor-I, Angiopoietin 1 (Ang1), and Ang2 transcription. Bortezomib 0-10 interleukin 6 Homo sapiens 113-117 16397231-7 2006 Bortezomib triggered a dose-dependent inhibition of vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) secretion by the MMECs, and reverse transcriptase-PCR confirmed drug-related down-regulation of VEGF, IL-6, insulin-like growth factor-I, Angiopoietin 1 (Ang1), and Ang2 transcription. Bortezomib 0-10 interleukin 6 Homo sapiens 221-225 16824780-6 2006 The induction of nitroblue tetrazolium reduction and adhesion abilities in THP-1 cells was closely correlated with the concentrations of interleukin-6 protein in the culture supernatants. Nitroblue Tetrazolium 17-38 interleukin 6 Homo sapiens 137-150 16711008-1 2006 In order to characterize the effects of 17beta-estradiol (17beta-E2) on the expression of IL-6, IL-11 and NF-kappaB in the human MG-63 osteoblast-like cell line, the expression of IL-6 was detected by RT-PCR, Northern blot and Western blot. 17beta-e2 58-67 interleukin 6 Homo sapiens 90-94 16711008-3 2006 The results showed that 17beta-E2 down-regulated the expression of IL-6 mRNA and protein, IL-11 mRNA and NF-kappaB protein in MG-63 cells. 17beta-e2 24-33 interleukin 6 Homo sapiens 67-71 16543969-5 2006 17beta-dihydroequilenin and 17beta-estradiol at a concentration of 1 microM reduced IL-1alpha-induced up regulation of IL-6, IL-8 and MCP-1 close to control levels. 17-dihydroequilenin 0-23 interleukin 6 Homo sapiens 119-123 16543969-8 2006 The effect of 17beta-dihydroequilenin on IL-1alpha-induced production of IL-6, IL-8 and MCP-1 was reversed by the estrogen receptor antagonist ICI 182,780. 17-dihydroequilenin 14-37 interleukin 6 Homo sapiens 73-77 16155293-8 2005 Collectively, these data demonstrate for the first time that trans-10, cis-12 CLA promotes NFkappaB activation and subsequent induction of IL-6, which are at least in part responsible for trans-10, cis-12 CLA-mediated suppression of peroxisome proliferator-activated receptor gamma target gene expression and insulin sensitivity in mature human adipocytes. trans-10,cis-12-conjugated linoleic acid 61-81 interleukin 6 Homo sapiens 139-143 16155367-10 2005 This new structural class of PPAR-gamma agonists inhibited the expression of ICAM-1 and the production of IL-6 and MCP-1 in TNF-alpha-activated ECs at lower concentrations than other synthetic PPAR-gamma agonists, suggesting the potential clinical utility of 1,1-bis(3"-indolyl)-1-(p-substituted phenyl) methanes for decreasing endothelial inflammation. 1,1-bis(3"-indolyl)-1-(p-substituted phenyl) methanes 259-312 interleukin 6 Homo sapiens 106-110 16123700-2 2005 As revealed by ELISA, capsaicin induced IL-6 expression in PF-10 cells, and the VR1 antagonist capsazepine dose-dependently inhibited capsaicin-induced IL-6 production, indicating that capsaicin-induced IL-6 expression is related to VR1 activation. capsazepine 95-106 interleukin 6 Homo sapiens 152-156 16123700-2 2005 As revealed by ELISA, capsaicin induced IL-6 expression in PF-10 cells, and the VR1 antagonist capsazepine dose-dependently inhibited capsaicin-induced IL-6 production, indicating that capsaicin-induced IL-6 expression is related to VR1 activation. capsazepine 95-106 interleukin 6 Homo sapiens 152-156 16708557-0 2005 [The influence of IL-6 polymorphism on efficacy of treatment of rheumatoid arthritis patients with methotrexate and prednisone]. Methotrexate 99-111 interleukin 6 Homo sapiens 18-22 16708557-5 2005 The aim of the present study was to examine the influence of - 174 interleukin-6 (IL-6) promoter polymorphism on the efficacy of treatment of RA patients with methotrexate and prednisone. Methotrexate 159-171 interleukin 6 Homo sapiens 67-80 16708557-5 2005 The aim of the present study was to examine the influence of - 174 interleukin-6 (IL-6) promoter polymorphism on the efficacy of treatment of RA patients with methotrexate and prednisone. Methotrexate 159-171 interleukin 6 Homo sapiens 82-86 16708557-12 2005 We suggest that -174 IL-6 promoter polymorphism may be a genetic risk factor determining the effectiveness of RA treatement with methotrexate and glucocorticosteroids. Methotrexate 129-141 interleukin 6 Homo sapiens 21-25 15860671-9 2005 In addition, IFN treatment attenuated the interleukin 6 (IL-6)-dependent activation of signal transducer and activator of transcription 3 (Stat3), interfering with a known survival pathway in MM that has previously been linked with resistance to Fas-mediated apoptosis. ammonium ferrous sulfate 246-249 interleukin 6 Homo sapiens 42-55 15954968-9 2005 Alveolar cell TNFalpha concentrations after surgery were also greater with desflurane than sevoflurane (96.3 +/- 12.4 pg ml(-1) vs. 64.8 +/- 10.1 pg ml(-1), P < 0.001), as were interleukin 1beta (75.4 +/- 6.2 pg ml(-1) vs. 32.0 +/- 8.3 pg ml(-1), P < 0.001) and interleukin 6 concentrations (540.1 +/- 65.3 pg ml(-1) vs. 363.6 +/- 29.2 pg ml(-1), P < 0.001). Desflurane 75-85 interleukin 6 Homo sapiens 268-281 15969670-0 2005 The mycotoxins citrinin and gliotoxin differentially affect production of the pro-inflammatory cytokines tumour necrosis factor-alpha and interleukin-6, and the anti-inflammatory cytokine interleukin-10. Citrinin 15-23 interleukin 6 Homo sapiens 138-151 15969670-13 2005 We suggest that low exposure doses of citrinin and gliotoxin (corresponding to less than 100 ng/mL gliotoxin and less than 10 mug/mL citrinin) may inhibit IL-10 and lead to increased risk of an inflammatory response with relative overproduction of TNF-alpha and IL-6. Citrinin 38-46 interleukin 6 Homo sapiens 262-266 15790413-11 2005 The primary endpoint for the study is the influence of fluvastatin therapy on levels of inflammatory markers (CRP and interleukin-6) and on pregnancy associated plasma protein A (PAPP-A). Fluvastatin 55-66 interleukin 6 Homo sapiens 118-131 15790343-9 2005 CONCLUSIONS: This result strengthened the importance of IL6 genotypes in the pathogenesis of RSA of unknown cause in the south Brazilian population. rabbit sperm membrane autoantigen 93-96 interleukin 6 Homo sapiens 56-59 15935563-5 2005 Anti-inflammatory properties of statins and bisphosphonates are due to isoprenoid depletion with subsequent inhibition of IL-6 mediated inflammation. Diphosphonates 44-59 interleukin 6 Homo sapiens 122-126 15935563-7 2005 Prevention of atherosclerotic vascular disease and age-related disorders will be by utilization of cholesterol lowering agents or techniques and/or treatment with statins and/or bisphosphonates to inhibit IL-6 inflammation through regulation of cholesterol metabolism. Diphosphonates 178-193 interleukin 6 Homo sapiens 205-209 15588145-8 2005 L-NNA treatment (2 x 25 mg/kg) caused aggravation of edematous AP to the necrotizing situation, and increased IL-6 and hematocrit levels. Nitroarginine 0-5 interleukin 6 Homo sapiens 110-114 15593217-11 2004 Lipopolysaccharide- or lipoteichoic acid-mediated triggering of PBMCs incubated with IL-12/IL-18 or IFNgamma led to an increased production of both TNFalpha and IL-6, indicating the functionality of TLR-2 and TLR-4. lipoteichoic acid 23-40 interleukin 6 Homo sapiens 161-165 15569984-3 2004 We show here that the TGF-beta receptor I kinase inhibitor SD-208 significantly decreases secretion of both IL-6 and vascular endothelial growth factor (VEGF) from BMSCs, as well as tumor cell growth triggered by MM cell adhesion to BMSCs. SD-208 59-65 interleukin 6 Homo sapiens 108-112 15569984-5 2004 Effects of SD-208 on TGF-beta1-induced signaling pathways triggering IL-6 and VEGF transcription in BMSCs were also delineated. SD-208 11-17 interleukin 6 Homo sapiens 69-73 15569984-6 2004 RESULTS: SD-208 significantly inhibits not only transcription but also secretion of both IL-6 and VEGF from BMSCs triggered by either TGF-beta1 or adhesion of MM cells to BMSCs. SD-208 9-15 interleukin 6 Homo sapiens 89-93 15217830-4 2004 Low-dose combined PK and bortezomib treatment overcomes the growth, survival, and drug resistance conferred by interleukin-6 or insulin growth factor within the MM bone marrow milieu. Bortezomib 25-35 interleukin 6 Homo sapiens 111-124 15115713-8 2004 Both IFNgamma and IL6 levels were significantly reduced after methotrexate treatment. Methotrexate 62-74 interleukin 6 Homo sapiens 18-21 15356085-6 2004 By comparison of 3-month changes between randomized subgroups, the addition of low-dose flutamide was found to have consistently (more) normalizing effects on low-density lipoprotein cholesterol, IL-6, and adiponectin, lean body mass, total and abdominal fat mass, and arterial flow in the ovaries. Flutamide 88-97 interleukin 6 Homo sapiens 196-200 15090453-5 2004 Quantitation of proliferation, apoptosis, and interleukin 6 (IL-6) and IL-10 secretion by tumor cells in culture revealed that the effects of PS-341 on cell growth largely correlated with inhibition of pathways mediated by NF-kappaB. Bortezomib 142-148 interleukin 6 Homo sapiens 46-59 15090453-5 2004 Quantitation of proliferation, apoptosis, and interleukin 6 (IL-6) and IL-10 secretion by tumor cells in culture revealed that the effects of PS-341 on cell growth largely correlated with inhibition of pathways mediated by NF-kappaB. Bortezomib 142-148 interleukin 6 Homo sapiens 61-65 15145616-0 2004 Corticosteroid resistance in a subpopulation of multiple sclerosis patients as measured by ex vivo dexamethasone inhibition of LPS induced IL-6 production. ex vivo dexamethasone 91-112 interleukin 6 Homo sapiens 139-143 15109670-1 2004 Zoanthamines are a family of marine alkaloids that have complex heptacyclic structures and are reported to be interleukin-6 modulators. zoanthamine 0-12 interleukin 6 Homo sapiens 110-123 15109670-1 2004 Zoanthamines are a family of marine alkaloids that have complex heptacyclic structures and are reported to be interleukin-6 modulators. Alkaloids 36-45 interleukin 6 Homo sapiens 110-123 15050655-10 2004 However, in the low SES group, IL-6 continued to increase between 75 min and 2h post-stress, whereas IL-6 levels stabilised at 75 min in the high SES group. Deuterium 77-79 interleukin 6 Homo sapiens 31-35 15190969-9 2004 The increase in interleukin-6 plasma concentration was then followed (12 and 24 hrs after surgery) by a significant reduction of Pao2/ FIO2 and Pao2/PAO2 ratios (p < .05 vs. abdominal surgery). pao2 129-133 interleukin 6 Homo sapiens 16-29 15190969-9 2004 The increase in interleukin-6 plasma concentration was then followed (12 and 24 hrs after surgery) by a significant reduction of Pao2/ FIO2 and Pao2/PAO2 ratios (p < .05 vs. abdominal surgery). pao2 144-148 interleukin 6 Homo sapiens 16-29 15190969-9 2004 The increase in interleukin-6 plasma concentration was then followed (12 and 24 hrs after surgery) by a significant reduction of Pao2/ FIO2 and Pao2/PAO2 ratios (p < .05 vs. abdominal surgery). pao2 149-153 interleukin 6 Homo sapiens 16-29 14749354-7 2004 The induction by forskolin plus DHT or by either agent or by IL-6 alone was greatly inhibited by H-89, indicating the involvement of protein kinase A in the actions of forskolin, DHT, and IL-6. Colforsin 17-26 interleukin 6 Homo sapiens 188-192 14749354-7 2004 The induction by forskolin plus DHT or by either agent or by IL-6 alone was greatly inhibited by H-89, indicating the involvement of protein kinase A in the actions of forskolin, DHT, and IL-6. Colforsin 168-177 interleukin 6 Homo sapiens 61-65 15217654-10 2004 However, the elevation of the plasma IL-6 level in the PGE(1)-H group was found during hypotension, compared with the control group (p < 0.05). Prostaglandins E 55-58 interleukin 6 Homo sapiens 37-41 14754894-5 2004 On the other hand, the IL-6 gene was quickly induced by Bt(2)AMP/theophylline, and subsequent IL-6 protein secretion was stimulated. Theophylline 65-77 interleukin 6 Homo sapiens 23-27 14754894-7 2004 Most importantly, treatment with IL-6-neutralizing antibody dramatically reduced the cAMP-induced GFAP expression and STAT3 phosphorylation and reversed the cellular morphological changes that had been caused by Bt(2)AMP/theophylline. Theophylline 221-233 interleukin 6 Homo sapiens 33-37 14754894-8 2004 Taken together, these results indicated that Bt(2)AMP/theophylline lead to delayed STAT3 activation via autocrine IL-6. Theophylline 54-66 interleukin 6 Homo sapiens 114-118 14563701-6 2004 Isolation of Triton X-100-insoluble raft fractions from LNCaP cells by discontinuous sucrose gradient centrifugation demonstrated that the 80-kDa IL-6 receptor localized almost exclusively to the raft compartment. Octoxynol 13-25 interleukin 6 Homo sapiens 146-150 14975242-3 2004 Here we demonstrate that expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in MM cells and its agonists 15-d-PGJ2 and troglitazone completely abolished IL-6-inducible MM cell proliferation and induced apoptosis through affecting expression of multiple cell cycle or apoptosis genes, whereas PPARgamma antagonist GW9662 and PPARalpha agonist WY14643 did not display this inhibitory effect. Troglitazone 143-155 interleukin 6 Homo sapiens 177-181 14975242-3 2004 Here we demonstrate that expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in MM cells and its agonists 15-d-PGJ2 and troglitazone completely abolished IL-6-inducible MM cell proliferation and induced apoptosis through affecting expression of multiple cell cycle or apoptosis genes, whereas PPARgamma antagonist GW9662 and PPARalpha agonist WY14643 did not display this inhibitory effect. pirinixic acid 366-373 interleukin 6 Homo sapiens 177-181 14741428-5 2004 In contrast to its effects on IL-1alpha and IL-1beta secretion, BzATP induced TNF-alpha after LPS stimulation, but not after stimulation with Abeta(1-42), induced IL-18 secretion regardless of whether microglia were pre-activated and attenuated IL-6 secretion after either LPS or Abeta(1-42) pre-activation. BzATP 64-69 interleukin 6 Homo sapiens 245-249 15044817-4 2004 A significant correlation was observed between the PMMA-CHDF-induced increase in the percentage of apoptotic PMNs and the degree of decrease in the serum interleukin-6 level. Polymethyl Methacrylate 51-55 interleukin 6 Homo sapiens 154-167 15044817-4 2004 A significant correlation was observed between the PMMA-CHDF-induced increase in the percentage of apoptotic PMNs and the degree of decrease in the serum interleukin-6 level. chdf 56-60 interleukin 6 Homo sapiens 154-167 15561686-26 2004 Blockade of NF-kappa B using the proteasome inhibitor bortezomib (Velcade) may mediate anti-MM activity by inhibiting interleukin (IL)-6 production in stromal cells and other mechanisms of action have been shown in preclinical studies. Bortezomib 54-64 interleukin 6 Homo sapiens 118-136 15561686-26 2004 Blockade of NF-kappa B using the proteasome inhibitor bortezomib (Velcade) may mediate anti-MM activity by inhibiting interleukin (IL)-6 production in stromal cells and other mechanisms of action have been shown in preclinical studies. Bortezomib 66-73 interleukin 6 Homo sapiens 118-136 14666025-3 2003 This study was designed to compare the effects of epsilon-aminocaproic acid and aprotinin on plasma levels of interleukin-6 and interleukin-8 during and after cardiopulmonary bypass. Aminocaproic Acid 50-75 interleukin 6 Homo sapiens 110-123 14666025-10 2003 CONCLUSIONS: When dosed in a similar manner, epsilon-aminocaproic acid seems to be as effective as aprotinin at reducing interleukin-6 and interleukin-8 levels in patients undergoing primary coronary artery bypass graft surgery. Aminocaproic Acid 45-70 interleukin 6 Homo sapiens 121-134 12714376-6 2003 Using RNase protection assays, we showed that IL-6 enhanced Fas-induced apoptosis and expression of Bax in normal-Fb, but inhibited apoptosis and induced expression of Bcl-2 in IPF-Fb. ammonium ferrous sulfate 60-63 interleukin 6 Homo sapiens 46-50 12739045-0 2003 Methotrexate inhibits interleukin-6 production in patients with juvenile rheumatoid arthritis. Methotrexate 0-12 interleukin 6 Homo sapiens 22-35 12739045-7 2003 The two groups of patients, i.e., those treated with placebo and those treated with MTX, had similar spontaneous and induced IL-6 and TNFalpha production. Methotrexate 84-87 interleukin 6 Homo sapiens 125-129 12721390-7 2003 Conversely, the TRPV1 antagonist capsazepine, as well as calcium chelation by EGTA ablated cytokine (IL-6) production after capsaicin exposure. capsazepine 33-44 interleukin 6 Homo sapiens 101-105 12640021-3 2003 Infusion with HiIL-6 and LoIL-6 resulted in a marked (P < 0.05) increase in systemic IL-6 concentration throughout the 3 h of infusion (mean arterial plasma [IL-6]s of 319 and 143 pg ml-1 for HiIL-6 and LoIL-6, respectively), followed by a rapid decline (P < 0.05) during the recovery period. hiil 195-199 interleukin 6 Homo sapiens 16-20 12640021-3 2003 Infusion with HiIL-6 and LoIL-6 resulted in a marked (P < 0.05) increase in systemic IL-6 concentration throughout the 3 h of infusion (mean arterial plasma [IL-6]s of 319 and 143 pg ml-1 for HiIL-6 and LoIL-6, respectively), followed by a rapid decline (P < 0.05) during the recovery period. hiil 195-199 interleukin 6 Homo sapiens 27-31 12729473-0 2003 Medroxyprogesterone acetate decreases secretion of interleukin-6 and parathyroid hormone-related protein in a new anaplastic thyroid cancer cell line, KTC-2. Medroxyprogesterone Acetate 0-27 interleukin 6 Homo sapiens 51-64 12729473-8 2003 Our previous studies revealed that medroxyprogesterone acetate (MPA) reduces secretion of IL-6 and PTHrP from human breast cancer cells. Medroxyprogesterone Acetate 35-62 interleukin 6 Homo sapiens 90-94 12468058-8 2003 Changes in IL-6 (DeltaIL-6) correlated with Deltaepinephrine (r=0.63, P<0.0001) and Deltanorepinephrine (r=0.57, P=0.0006) in controls, but not in CHF. deltanorepinephrine 87-106 interleukin 6 Homo sapiens 11-15 12438339-8 2002 Although Pg-LPS could not make cells tolerant to subsequent activation by Ec-LPS, Pg-LPS inhibited Ec-LPS-induced TNF-alpha and IL-6 release when the two molecules were added simultaneously into THP-1 cell cultures. pg-lps 82-88 interleukin 6 Homo sapiens 128-132 12586136-12 2002 Enalapril also down-regulated the basal expression of IL-6 (p=0.01) and IL-10 (p<0.01) in HCAEC, which simvastatin and dalteparin failed to do. Enalapril 0-9 interleukin 6 Homo sapiens 54-58 12163195-3 2002 Therefore, the present study was aimed to investigate serum tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6 levels in association with the disease stage, cytosine-thymine-guanine (CTG) expansion and cardiac function of 56 patients with DM1 (40+/-14 years) and 28 healthy controls (42+/-12 years). cytosine-thymine-guanine 174-198 interleukin 6 Homo sapiens 123-127 12215492-6 2002 On the other hand, PPAR-gamma ligands troglitazone, pioglitazone, and 15-deoxy-Delta(12,14)-prostaglandin J(2) inhibited IL-1beta-induced IL-6 expression at a transcriptional revel in VSMCs. Troglitazone 38-50 interleukin 6 Homo sapiens 138-142 12297109-5 2002 Using reverse transcriptase-polymerase chain reaction (RT-PCR), immunoprecipitation and western blot analysis, we report that the early signalling events triggered by the hIL-17 involved tyrosyl phosphorylation of proteins and increased the levels of IL-6, IL-8 and MCP-1 in a dose-dependent manner. cyclo(tyrosyl-tyrosyl) 187-194 interleukin 6 Homo sapiens 251-255 12162776-8 2002 Meloxicam (a specific COX-2 inhibitor) suppressed the induction of cytokines on IL-6 mRNA levels, and these effects could be reversed by exogenous prostaglandin E(2). Prostaglandins E 147-162 interleukin 6 Homo sapiens 80-84 12165097-4 2002 Incubation of FLS with a synthetic PPARgamma ligand, troglitazone, inhibited endogenous production of TNF-alpha, IL-6 and IL-8, as well as matrix metalloprotease-3 (MMP-3), without inducing apoptosis of the cells. Troglitazone 53-65 interleukin 6 Homo sapiens 113-117 12143044-5 2002 HGF and IL-6 also induced a rapid release of arachidonic acid (AA) from SG231 and increased the synthesis of PGE(2) and PGF(2)alpha. Prostaglandins E 109-112 interleukin 6 Homo sapiens 8-12 12492118-4 2002 Specifically, As2O3 at clinically achievable levels (2-5 microM) induces apoptosis even of drug-resistant MM cell lines and patient cells via caspase-9 activation, enhances the MM cell apoptosis induced by dexamethasone, and can overcome the antiapoptotic effects of interleukin 6. Arsenic Trioxide 14-19 interleukin 6 Homo sapiens 267-280 12492118-5 2002 As2O3 also acts in the BM microenvironment to decrease MM cell binding to BM stromal cells, inhibits interleukin 6 and vascular endothelial growth factor secretion induced by MM cell adhesion, and blocks proliferation of MM cells adherent to BM stromal cells. Arsenic Trioxide 0-5 interleukin 6 Homo sapiens 101-114 12085250-12 2002 More specifically, docetaxel demonstrated a more pronounced effect on enhancing MLR, NK, LAK activity and IFN-gamma, IL-2, IL-6, and GM-CSF levels, as well as caused more potent reduction in IL-1 and TNF-alpha levels when compared to paclitaxel. Docetaxel 19-28 interleukin 6 Homo sapiens 123-127 12010778-2 2002 We examined the effects of endogenous prostaglandin E(2) (PGE(2)) on the production of interleukin-6 (IL-6), macrophage colony stimulating factor (M-CSF), and vascular endothelial growth factor (VEGF) by interleukin-1beta (IL-1beta)-stimulated human synovial fibroblasts. Prostaglandins E 58-61 interleukin 6 Homo sapiens 87-100 12010778-7 2002 8-Bromo cyclic AMP and dibutyryl cyclic AMP, cyclic AMP analogues, mimicked the effects of PGE(2) on IL-6, M-CSF, and VEGF production by OA fibroblasts. Prostaglandins E 91-94 interleukin 6 Homo sapiens 101-105 12010778-14 2002 These results suggest that endogenous PGE(2) regulates the production of IL-6, M-CSF, and VEGF by IL-1beta-stimulated human synovial fibroblasts through the activation of EP(2) and EP(4) receptors with increase in cyclic AMP. Prostaglandins E 38-41 interleukin 6 Homo sapiens 73-77 11953371-8 2002 In contrast, IL-6 and IL-11 significantly suppressed butyric acid- or Fas-induced apoptosis in a dose-dependent fashion. ammonium ferrous sulfate 70-73 interleukin 6 Homo sapiens 13-17 11981085-7 2002 There was an association between symptoms and increased levels of mycophenolic acid (MPA) acyl glucuronide and serum interleukin-6, suggesting the induction of inflammatory cytokines by MPA acyl glucuronide as the cause of the syndrome. acyl glucuronide 90-106 interleukin 6 Homo sapiens 117-130 11919735-15 2002 With KL, FL, TPO +/- IL6 it is possible to expand haemopoietic progenitor cells in a SF medium. sf medium 85-94 interleukin 6 Homo sapiens 21-24 12090904-3 2002 We investigated the effects of fluvastatin on IL-6 synthesis in human vascular smooth muscle cells (VSMCs). Fluvastatin 31-42 interleukin 6 Homo sapiens 46-50 12090904-4 2002 Addition of fluvastatin decreased IL-6 synthesis in VSMCs in a time (0-24 hours)- and dose (10(-8)-10(-5) mol/L)-dependent manner. Fluvastatin 12-23 interleukin 6 Homo sapiens 34-38 12090904-5 2002 Fluvastatin also decreased IL-6 mRNA expression in VSMCs. Fluvastatin 0-11 interleukin 6 Homo sapiens 27-31 12090904-6 2002 The effects of fluvastatin on IL-6 expression were completely reversed in the presence of mevalonate or geranylgeranyl-pyrophosphate, but not squalene. Fluvastatin 15-26 interleukin 6 Homo sapiens 30-34 12090904-8 2002 In conclusion, fluvastatin decreases IL-6 synthesis in human VSMCs through inhibition of Rho pathway. Fluvastatin 15-26 interleukin 6 Homo sapiens 37-41 11991654-2 2002 Our data show that there was a significant increase of IL-6 and IgM production in BMNH after exposure to LPL. lpl 105-108 interleukin 6 Homo sapiens 55-59 12476615-2 2002 Our study was designed to determine whether heat shock and drugs like cisplatin, etoposide and quercetin influence the expression of heat shock protein 72 in tumour cells: HeLa (cervical cancer), Hep-2 (larynx cancer), A549 (lung cancer) and normal human skin fibroblasts (HSF). Quercetin 95-104 interleukin 6 Homo sapiens 273-276 12476615-5 2002 Quercetin inhibited heat shock protein expression in Hep-2 cells but induced in HSF. Quercetin 0-9 interleukin 6 Homo sapiens 80-83 11287357-10 2001 Plasma IL-6 was significantly associated with plasma nonesterified fatty acid levels (r = 0.49, P < 0.002). Fatty Acids, Nonesterified 53-77 interleukin 6 Homo sapiens 7-11 11306489-3 2001 In this study, we demonstrate that the proteasome inhibitor PS-341 directly inhibits proliferation and induces apoptosis of human MM cell lines and freshly isolated patient MM cells; inhibits mitogen-activated protein kinase growth signaling in MM cells; induces apoptosis despite induction of p21 and p27 in both p53 wild-type and p53 mutant MM cells; overcomes drug resistance; adds to the anti-MM activity of dexamethasone; and overcomes the resistance to apoptosis in MM cells conferred by interleukin-6. Bortezomib 60-66 interleukin 6 Homo sapiens 494-507 11306489-4 2001 PS-341 also inhibits the paracrine growth of human MM cells by decreasing their adherence to bone marrow stromal cells (BMSCs) and related nuclear factor kappaB-dependent induction of interleukin-6 secretion in BMSCs, as well as inhibiting proliferation and growth signaling of residual adherent MM cells. Bortezomib 0-6 interleukin 6 Homo sapiens 184-197 11309322-13 2001 CONCLUSIONS: Addition of TNF to melphalan during IHP results in significant differences in post-IHP production of IL-6 and IL-8 with associated changes in mean arterial blood pressure and greater regional toxicity, as reflected in higher levels of serum bilirubin. Melphalan 32-41 interleukin 6 Homo sapiens 114-118 11236942-8 2001 Doxorubicin and melphalan were able to suppress bcl-XL expression only in the presence of IL-6. Melphalan 16-25 interleukin 6 Homo sapiens 90-94 11133502-2 2001 Prostaglandin (PG) E(2) (10(-7) M) treatment caused an increase in IL-6 release at 2, 4, 8, and 24 h. IL-6 release into the culture medium at 24 h was 3,396 +/- 306 vs. 1,051 +/- 154 pg/ml (PGE(2)-treated cells vs. control cells). Prostaglandins E 0-20 interleukin 6 Homo sapiens 67-71 11133502-2 2001 Prostaglandin (PG) E(2) (10(-7) M) treatment caused an increase in IL-6 release at 2, 4, 8, and 24 h. IL-6 release into the culture medium at 24 h was 3,396 +/- 306 vs. 1,051 +/- 154 pg/ml (PGE(2)-treated cells vs. control cells). Prostaglandins E 0-20 interleukin 6 Homo sapiens 102-106 11133502-2 2001 Prostaglandin (PG) E(2) (10(-7) M) treatment caused an increase in IL-6 release at 2, 4, 8, and 24 h. IL-6 release into the culture medium at 24 h was 3,396 +/- 306 vs. 1,051 +/- 154 pg/ml (PGE(2)-treated cells vs. control cells). Prostaglandins E 190-193 interleukin 6 Homo sapiens 102-106 11133502-3 2001 PGE(2) (10(-7) to 10(-10) M) induced a dose-related increase in IL-6 release at 24 h. PGF(2 alpha) (10(-6) M) treatment caused a similar effect to that of PGE(2) (10(-7) M). Prostaglandins E 0-3 interleukin 6 Homo sapiens 64-68 11133502-3 2001 PGE(2) (10(-7) to 10(-10) M) induced a dose-related increase in IL-6 release at 24 h. PGF(2 alpha) (10(-6) M) treatment caused a similar effect to that of PGE(2) (10(-7) M). Prostaglandins E 155-158 interleukin 6 Homo sapiens 64-68 11173548-7 2001 In addition, administration of PCI-43h, but not PCI-43 suppressed the growth of PCI-43 that was xenografted 4 weeks later, thus revealing a vaccination effect of IL-6-producing PCI-43h, but not IL-6-nonproducing PCI-43. pci-43h 177-184 interleukin 6 Homo sapiens 162-166 10880077-13 2000 Pretreatment of fibroblasts with pertussis toxin inhibited the release of interleukin-6 and MCP-1 from PMMA and titanium particle challenged fibroblasts in a dose-dependent manner. Polymethyl Methacrylate 103-107 interleukin 6 Homo sapiens 74-87 10880077-14 2000 PMMA particle induced fibroblast IL-6 release was inhibited by 23.6% and 35.3% with 20- and 200-ng/mL doses of pertussis toxin, respectively. Polymethyl Methacrylate 0-4 interleukin 6 Homo sapiens 33-37 10928984-3 2000 The pan-COX inhibitor ketorolac continuously and significantly decreased PGE(2) production and IL-6 and IL-8 levels in all OPC cell lines tested, but did not affect IL-1alpha, GM-CSF levels, or in vitro tumor cell growth. Ketorolac 22-31 interleukin 6 Homo sapiens 95-99 10888991-0 2000 Interleukin 6 may be an important mediator of trimethoprim-induced systemic adverse reaction resembling aseptic meningitis. Trimethoprim 46-58 interleukin 6 Homo sapiens 0-13 10834930-2 2000 Whereas catecholamines decrease the LPS-induced production of IL-6 by leukocytes, serum levels of IL-6 are dramatically increased by the catecholamine epinephrine in animal endotoxemia models. catecholamine epinephrine 137-162 interleukin 6 Homo sapiens 98-102 10720087-6 2000 Serum IL-6 levels correlated positively with fasting triglycerides, VLDL-triglycerides, and postload free fatty acids (r = 0.61, 0.65 and 0.60, respectively; P < 0.001) and negatively with high-density lipoprotein-cholesterol (r = -0.42, P < 0.05). Fatty Acids, Nonesterified 101-117 interleukin 6 Homo sapiens 6-10 11268388-3 2000 Interleukin-1 beta (IL-1 beta) stimulates IL-6 release from anterior pituitary cells through a mechanism that involves lysophosphatidylcholine (LPC 18:0) generation and protein kinase C activation. Lysophosphatidylcholines 119-142 interleukin 6 Homo sapiens 42-46 11029783-3 2000 A decrease in serum IL-6 levels induced by medroxyprogesterone acetate (MPA) has been reported to correlate with a reversion of body weight loss in patients with advanced breast cancer. Medroxyprogesterone Acetate 43-70 interleukin 6 Homo sapiens 20-24 11029783-3 2000 A decrease in serum IL-6 levels induced by medroxyprogesterone acetate (MPA) has been reported to correlate with a reversion of body weight loss in patients with advanced breast cancer. Medroxyprogesterone Acetate 72-75 interleukin 6 Homo sapiens 20-24 11029783-8 2000 Docetaxel increased IL-6 levels in both serum and KPL-4 tumors, but combined treatment with docetaxel and 5"-DFUR resulted not only in a potent antitumor effect but also in a drastic decrease of serum IL-6 levels. Docetaxel 0-9 interleukin 6 Homo sapiens 20-24 11029783-8 2000 Docetaxel increased IL-6 levels in both serum and KPL-4 tumors, but combined treatment with docetaxel and 5"-DFUR resulted not only in a potent antitumor effect but also in a drastic decrease of serum IL-6 levels. Docetaxel 92-101 interleukin 6 Homo sapiens 201-205 11029784-0 2000 Medroxyprogesterone acetate and cancer cachexia: interleukin-6 involvement. Medroxyprogesterone Acetate 0-27 interleukin 6 Homo sapiens 49-62 11029784-4 2000 A recent prospective study revealed that oral medroxyprogesterone acetate (MPA) treatment reduces serum levels of interleukin (IL)-6, an important mediator of cancer cachexia, in patients with metastatic breast carcinoma regardless of response to the therapy. Medroxyprogesterone Acetate 46-73 interleukin 6 Homo sapiens 114-132 10840075-10 2000 The profound and rapid 7.5-fold increase in the natural antagonist of human IL-6 cytokine family after RA treatment could abrogate the gp130 signaling required for proliferation and/or expansion of human primitive hemopoietic stem cells and lead to the observed inhibitory effect of RA on CAFC. cafc 289-293 interleukin 6 Homo sapiens 76-80 10590836-3 1999 As the cellular heat shock response also involves the activation of heat shock transcription factor (HSF), we have, in the present study, examined the role of HSF in the stress potentiation of GR by use of a flavonoid compound, quercetin, recently shown to selectively inhibit the stress response in a variety of human and murine cell lines. Quercetin 228-237 interleukin 6 Homo sapiens 101-104 10590836-3 1999 As the cellular heat shock response also involves the activation of heat shock transcription factor (HSF), we have, in the present study, examined the role of HSF in the stress potentiation of GR by use of a flavonoid compound, quercetin, recently shown to selectively inhibit the stress response in a variety of human and murine cell lines. Quercetin 228-237 interleukin 6 Homo sapiens 159-162 10590836-6 1999 In L929 cells stably transfected with a CAT reporter plasmid under the control of the HSF-responsive hsp70 promoter (LHSECAT cells), pretreatment with quercetin was found to cause a dose- and time-dependent inactivation of HSF activity following heat shock, but only when added before the stress event. Quercetin 151-160 interleukin 6 Homo sapiens 86-89 10590836-6 1999 In L929 cells stably transfected with a CAT reporter plasmid under the control of the HSF-responsive hsp70 promoter (LHSECAT cells), pretreatment with quercetin was found to cause a dose- and time-dependent inactivation of HSF activity following heat shock, but only when added before the stress event. Quercetin 151-160 interleukin 6 Homo sapiens 223-226 10590836-9 1999 Thus, quercetin appears to be an effective and selective inhibitor of HSF stress-induced activation and its ability to prevent the stress potentiation of GR suggests either a direct or indirect involvement by stress-activated HSF in this process, or the existence of a regulatory step common to both the heat shock and HSPE responses. Quercetin 6-15 interleukin 6 Homo sapiens 70-73 10590836-9 1999 Thus, quercetin appears to be an effective and selective inhibitor of HSF stress-induced activation and its ability to prevent the stress potentiation of GR suggests either a direct or indirect involvement by stress-activated HSF in this process, or the existence of a regulatory step common to both the heat shock and HSPE responses. Quercetin 6-15 interleukin 6 Homo sapiens 226-229 10569739-3 1999 We investigated a series of structurally related monosaccharide lipid A analogues for their potency to activate human macrophage U937 cells and peripheral blood mononuclear cells for production of tumor necrosis factor-alpha and interleukin-6 compared with their potency to activate murine macrophage RAW264.7 cells. Lipid A 64-71 interleukin 6 Homo sapiens 229-242 10620064-10 1999 In conclusion, the apoptosis of myeloma cells and BMSCs and the inhibition of both IL-6 and MMP-1 production induced by bisphosphonates, mainly zoledronate, could have antitumoral effects in patients with MM. Diphosphonates 120-135 interleukin 6 Homo sapiens 83-87 10606366-0 1999 Increased in vitro production of interleukin 6 in response to trimethoprim among persons with trimethoprim induced systemic adverse reactions. Trimethoprim 62-74 interleukin 6 Homo sapiens 33-46 10606366-0 1999 Increased in vitro production of interleukin 6 in response to trimethoprim among persons with trimethoprim induced systemic adverse reactions. Trimethoprim 94-106 interleukin 6 Homo sapiens 33-46 10606366-5 1999 RESULTS: Therapeutic trimethoprim concentration induced in the mononuclear cells of the trimethoprim reactive patients significantly higher IL-6 production [mean +/- SD (median), 2034+/-2965 (572) pg/ml] versus cells of the trimethoprim tolerant subjects [954+/-2552 (89) pg/ml; p = 0.036]. Trimethoprim 21-33 interleukin 6 Homo sapiens 140-144 10606366-5 1999 RESULTS: Therapeutic trimethoprim concentration induced in the mononuclear cells of the trimethoprim reactive patients significantly higher IL-6 production [mean +/- SD (median), 2034+/-2965 (572) pg/ml] versus cells of the trimethoprim tolerant subjects [954+/-2552 (89) pg/ml; p = 0.036]. Trimethoprim 88-100 interleukin 6 Homo sapiens 140-144 10606366-5 1999 RESULTS: Therapeutic trimethoprim concentration induced in the mononuclear cells of the trimethoprim reactive patients significantly higher IL-6 production [mean +/- SD (median), 2034+/-2965 (572) pg/ml] versus cells of the trimethoprim tolerant subjects [954+/-2552 (89) pg/ml; p = 0.036]. Trimethoprim 88-100 interleukin 6 Homo sapiens 140-144 10606366-7 1999 CONCLUSION: Trimethoprim induces IL-6 production in the peripheral blood mononuclear cells of trimethoprim reactive persons. Trimethoprim 12-24 interleukin 6 Homo sapiens 33-37 10606366-7 1999 CONCLUSION: Trimethoprim induces IL-6 production in the peripheral blood mononuclear cells of trimethoprim reactive persons. Trimethoprim 94-106 interleukin 6 Homo sapiens 33-37 10564193-9 1999 Antioxidants attenuated hypoxia-induced IL-6 secretion (13 +/- 2 pg/ml with ebselen and 19 +/- 3 pg/ml with NAC vs. 140 +/- 15 pg/ml with hypoxia). ebselen 76-83 interleukin 6 Homo sapiens 40-44 10632444-0 1999 Interleukin-4 inhibits granulocyte-macrophage colony-stimulating factor, interleukin-6, and tumor necrosis factor-alpha expression by human monocytes in response to polymethylmethacrylate particle challenge in vitro. Polymethyl Methacrylate 165-187 interleukin 6 Homo sapiens 73-119 10400874-6 1999 Exposure of the monocyte/macrophages to PMMA particles resulted in a dose-dependent release of interleukin-6 and tumor necrosis factor-alpha at 48 h. The interleukin-6 release in response to PMMA particle challenge was stimulated by 76% and 127% in the presence of 1.0 and 10.0 ng/mL of interferon-gamma, respectively. Polymethyl Methacrylate 191-195 interleukin 6 Homo sapiens 95-140 10400874-6 1999 Exposure of the monocyte/macrophages to PMMA particles resulted in a dose-dependent release of interleukin-6 and tumor necrosis factor-alpha at 48 h. The interleukin-6 release in response to PMMA particle challenge was stimulated by 76% and 127% in the presence of 1.0 and 10.0 ng/mL of interferon-gamma, respectively. Polymethyl Methacrylate 191-195 interleukin 6 Homo sapiens 95-108 10400874-11 1999 The data presented in this study demonstrate that the immunologic modulator interferon-gamma exacerbates monocyte/macrophage release of the pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-alpha in response to PMMA particle challenge in vitro. Polymethyl Methacrylate 228-232 interleukin 6 Homo sapiens 167-212 10528891-8 1999 In vitro blocking of an interleukin-6-dependent pathway with either a JAK inhibitor (tyrphostin, AG490) or STAT3 dominant negative (STAT3-DN) reduced expression of Bcl-xL (an antiapoptosis protein), increased spontaneous apoptosis, and enhanced sensitivity to Fas-mediated apoptosis. ammonium ferrous sulfate 260-263 interleukin 6 Homo sapiens 24-37 10378888-16 1999 CAFC frequency decreased after four divisions in culture with TPO, FL, and KL or after three divisions in TPO, FL, and IL-6. cafc 0-4 interleukin 6 Homo sapiens 119-123 10090171-8 1999 The cellular release of IL-1beta, TNF-alpha, and IL-6 was elevated in response to bleomycin exposure in both controls and patients with SSc. Bleomycin 82-91 interleukin 6 Homo sapiens 49-53 10027341-0 1999 Medroxyprogesterone acetate inhibits interleukin 6 secretion from KPL-4 human breast cancer cells both in vitro and in vivo: a possible mechanism of the anticachectic effect. Medroxyprogesterone Acetate 0-27 interleukin 6 Homo sapiens 37-50 10097794-3 1999 RESULTS: After stimulation with 2 ng/mL LPS for 24 hr, PMs from women with early-stage endometriosis secreted more NO, IL-6, and IL-10 than the controls. Promethium 55-58 interleukin 6 Homo sapiens 119-123 9920026-5 1999 Phosphorylation of GR was determined by specific immunoprecipitation of protein extracts from 32P-orthophosphate-labeled HSF. 32p-orthophosphate 94-112 interleukin 6 Homo sapiens 121-124 9681394-11 1998 Upregulation of IL-6 synthesis was significantly inhibited by alphaBCG or Cytochalasin B, indicating that internalization is a prerequisite for BCG-induced upregulation of IL-6 synthesis. alphabcg 62-70 interleukin 6 Homo sapiens 16-20 9681394-11 1998 Upregulation of IL-6 synthesis was significantly inhibited by alphaBCG or Cytochalasin B, indicating that internalization is a prerequisite for BCG-induced upregulation of IL-6 synthesis. alphabcg 62-70 interleukin 6 Homo sapiens 172-176 9575340-6 1998 Pretreatment with chlorisondamine, a ganglionic blocking agent, inhibited the Il-6 responses, while it had little influence on the TNF responses. Chlorisondamine 18-33 interleukin 6 Homo sapiens 78-82 2470133-2 1989 Hep 3B cells, when incubated with the cytokine interferon beta 2/B-cell stimulating factor 2/interleukin 6, secreted forms of alpha 1-protease inhibitor, ceruloplasmin, and alpha-fetoprotein with increased reactivity with concanavalin A (Con A) while incubation of Hep G2 cells with this cytokine led to secretion of forms of these proteins with decreased reactivity with Con A, reflecting changes in their oligosaccharide chains. Oligosaccharides 407-422 interleukin 6 Homo sapiens 93-152 6578348-6 1983 MSU (1 mg/ml) released hydroxyeicosatetraenoic acids (HETE) from HSF whereas 20-fold higher doses were required to release these metabolites from human polymorphonuclear leukocytes. Hydroxyeicosatetraenoic Acids 23-52 interleukin 6 Homo sapiens 65-68 6578348-6 1983 MSU (1 mg/ml) released hydroxyeicosatetraenoic acids (HETE) from HSF whereas 20-fold higher doses were required to release these metabolites from human polymorphonuclear leukocytes. Hydroxyeicosatetraenoic Acids 54-58 interleukin 6 Homo sapiens 65-68 33857595-13 2021 Furthermore, isoorientin, orientin, isovitexin, and vitexin produced significant concentration-dependent inhibition with IC50 values (muM) of COX-2: 7.13, 9.51, 12.81, 16.61; IL-1beta 4.80, 6.20, 10.85, 14.51; IL-6: 4.01, 5.90, 11.51 and 14.88 as compared to dexamethasone: 5.29, 2.93, 3.72, respectively (p<0.05). homoorientin 13-24 interleukin 6 Homo sapiens 210-214 33857595-13 2021 Furthermore, isoorientin, orientin, isovitexin, and vitexin produced significant concentration-dependent inhibition with IC50 values (muM) of COX-2: 7.13, 9.51, 12.81, 16.61; IL-1beta 4.80, 6.20, 10.85, 14.51; IL-6: 4.01, 5.90, 11.51 and 14.88 as compared to dexamethasone: 5.29, 2.93, 3.72, respectively (p<0.05). vitexin 39-46 interleukin 6 Homo sapiens 210-214 33677134-10 2021 Compared to the UVA-irradiated skin, 30 % TiO2/SBA-15 showed a 2.5- and 3.1-fold decline in IL-1beta and IL-6 levels, respectively. titanium dioxide 42-46 interleukin 6 Homo sapiens 105-109 33677134-10 2021 Compared to the UVA-irradiated skin, 30 % TiO2/SBA-15 showed a 2.5- and 3.1-fold decline in IL-1beta and IL-6 levels, respectively. sba 47-50 interleukin 6 Homo sapiens 105-109 2787674-2 1989 Using an anti-bromodeoxyuridine monoclonal antibody (MoAb) to specifically count myeloma cells in the S-phase (ie, labeling index, LI), we demonstrate that the IL-6 responsiveness of myeloma cells in vitro is directly correlated with their LI in vivo. Bromodeoxyuridine 14-31 interleukin 6 Homo sapiens 160-164 2523818-8 1989 Incubation of monocytes with tunicamycin and 1-deoxymynnojirimycin and treatment of IL-6 with endoglucosaminidase H suggested that the 27.5 kDa form of IL-6 carries at least one N-linked complex-type oligosaccharide chain. Oligosaccharides 200-215 interleukin 6 Homo sapiens 152-156 2575348-4 1989 The DNA damage in monocytes exposed to CdA is associated with a decrease in protein synthesis and with inhibitions of phagocytosis and IL-6 secretion. Cladribine 39-42 interleukin 6 Homo sapiens 135-139 3108877-0 1987 Rapid enhancement of beta 2-interferon/B-cell differentiation factor BSF-2 gene expression in human fibroblasts by diacylglycerols and the calcium ionophore A23187. Diglycerides 115-130 interleukin 6 Homo sapiens 69-74 3006091-2 1986 The specific binding and internalization of human 125I-labeled LDL are dose-dependently increased in HSF by CA of the verapamil series (verapamil, anipamil, gallopamil, ronipamil, and diltiazem), but neither by CA of the dihydropyridine series (nifedipine, nitrendipine) nor by flunarizine. Gallopamil 157-167 interleukin 6 Homo sapiens 101-104 3006091-2 1986 The specific binding and internalization of human 125I-labeled LDL are dose-dependently increased in HSF by CA of the verapamil series (verapamil, anipamil, gallopamil, ronipamil, and diltiazem), but neither by CA of the dihydropyridine series (nifedipine, nitrendipine) nor by flunarizine. 1,4-dihydropyridine 221-236 interleukin 6 Homo sapiens 101-104 33907855-9 2021 The results indicated that NTS demonstrated a protective effect against LPS-induced cell death and inhibited LPS-induced expression of TLR-4, JAK2, STAT3 and IL-6. nts 27-30 interleukin 6 Homo sapiens 158-162 33899283-7 2021 Ultimately, this gas-modulated PTT strategy inhibits tumor growth remarkably and limits the magnitude of PTT-induced proinflammatory tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) cytokines. Bialaphos 31-34 interleukin 6 Homo sapiens 174-187 33899283-7 2021 Ultimately, this gas-modulated PTT strategy inhibits tumor growth remarkably and limits the magnitude of PTT-induced proinflammatory tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) cytokines. Bialaphos 31-34 interleukin 6 Homo sapiens 189-193 33899283-7 2021 Ultimately, this gas-modulated PTT strategy inhibits tumor growth remarkably and limits the magnitude of PTT-induced proinflammatory tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) cytokines. Bialaphos 105-108 interleukin 6 Homo sapiens 174-187 33899283-7 2021 Ultimately, this gas-modulated PTT strategy inhibits tumor growth remarkably and limits the magnitude of PTT-induced proinflammatory tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) cytokines. Bialaphos 105-108 interleukin 6 Homo sapiens 189-193 34035828-9 2021 Further analysis showed that the HGD activity of quercetin, formononetin, kaempferol, isorhamnetin, and beta-sitosterol ingredients is possible through VEGFA, IL6, TNF, AKT1, and TP53 targets involved in TNF, toll-like receptors, and MAPK-related pathways, which have anti-inflammatory, antiapoptosis, antioxidation, and autophagy effects, relieve renal fibrosis and renal cortex injury, and improve renal function, thus delaying the development of DN. kaempferol 74-84 interleukin 6 Homo sapiens 159-162 34035828-10 2021 The molecular docking results showed that quercetin, formononetin, kaempferol, isorhamnetin, beta-sitosterol had a good binding activity with VEGFA, IL6, TNF, AKT1, and TP53. kaempferol 67-77 interleukin 6 Homo sapiens 149-152 33976537-8 2021 Lidocaine administration significantly reduced the release of IL-6, IL-10, TNF-alpha, and attenuated immune changes induced by trauma. Lidocaine 0-9 interleukin 6 Homo sapiens 62-66 33683214-10 2021 Cortisol, CRP and IL-6 levels were higher in patients with low TSH and FT3 levels. Thyrotropin 63-66 interleukin 6 Homo sapiens 18-22 33963719-8 2021 Several key targets including AKT1, IL- 6, JUN, TNF and CASP3 were screened for molecular docking, which had good binding activities with berberrubine, epiberberine, stigmasterol and sitosterol. epiberberine 152-164 interleukin 6 Homo sapiens 36-41 33639179-8 2021 There was evidence of publication bias for studies measuring IL-6 and IL-10 association with cocaine and IL-6 in association with cannabis. Cocaine 93-100 interleukin 6 Homo sapiens 61-65 33917265-10 2021 Production of IL1b, IL6 and TNFalpha dependent on the activation of TLR8 in PBMCs was also increased in patients before DAA treatment, with a significant reduction at week +48. daa 120-123 interleukin 6 Homo sapiens 20-23 34057124-4 2021 OBJECTIVE: This study aims to determine the effect of Dorsata honey (DH) as a complementary therapy to IL-6 levels and T lymphocytes of post-chemotherapy in breast cancer. 2-(3,5-dihydroxyphenyl)-6-hydroxybenzothiazole 69-71 interleukin 6 Homo sapiens 103-107 9499112-5 1998 Addition of therapeutic concentrations of dexamethasone (1 microM) or ribavirin (90 microg/ml), an antiviral agent, also significantly inhibited the synthesis of IL-6. Ribavirin 70-79 interleukin 6 Homo sapiens 162-166 9499112-6 1998 Hence, in clinical settings, pharmacological agents such as the specific antagonists of IL-6-inducing cytokines, as well as dexamethasone and ribavirin, could be used to modulate IL-6 production. Ribavirin 142-151 interleukin 6 Homo sapiens 179-183 33813381-9 2021 IL-6 production was increased following treatment with CDDP, but treatment with EPA decreased IL-6 levels. Eicosapentaenoic Acid 80-83 interleukin 6 Homo sapiens 94-98 9505142-5 1998 The upregulation of IL-6 production induced by BK was abolished by the anti-inflammatory agent dexamethasone (DEX) and the phospholipase A2 (PLA2) inhibitor 4-bromphenacyl bromide (BPB). bpb 181-184 interleukin 6 Homo sapiens 20-24 34023435-9 2021 In contrast, ML385 completely inhibited the expression of Nrf2 and IL-17D, transiently inhibited IL-6 and IL-4 expression, and did not influence KEAP1 expression. ML385 13-18 interleukin 6 Homo sapiens 97-101 9510918-0 1997 Madindolines, novel inhibitors of IL-6 activity from streptomyces sp. madindolines 0-12 interleukin 6 Homo sapiens 34-38 34025651-10 2021 During 8-12 weeks of ivacaftor-treatment, median values of IL-1beta and IL-6 significantly declined 2.29-fold (2.97 1.30 pg/mL), and 1.13-fold (6.48 5.72 pg/mL), respectively. ivacaftor 21-30 interleukin 6 Homo sapiens 72-76 33748269-13 2021 The findings also suggest that several ingredients of ABR such as Baicalien, Copistine, Epiberberine, Kaempferol, and Palmatine have good affinity with IL6, suggesting the promising potential of ABR in treating bone trauma, likely through IL6. abr 54-57 interleukin 6 Homo sapiens 152-155 33748269-13 2021 The findings also suggest that several ingredients of ABR such as Baicalien, Copistine, Epiberberine, Kaempferol, and Palmatine have good affinity with IL6, suggesting the promising potential of ABR in treating bone trauma, likely through IL6. abr 54-57 interleukin 6 Homo sapiens 239-242 33748269-13 2021 The findings also suggest that several ingredients of ABR such as Baicalien, Copistine, Epiberberine, Kaempferol, and Palmatine have good affinity with IL6, suggesting the promising potential of ABR in treating bone trauma, likely through IL6. epiberberine 88-100 interleukin 6 Homo sapiens 152-155 9351880-16 1997 In vitro, an increase in TNF alpha and a mild increase in IL-6 was seen with all bisphosphonates, with the greatest effects seen with the highest concentration of both pamidronate and zoledronate. Diphosphonates 81-96 interleukin 6 Homo sapiens 58-62 33748269-13 2021 The findings also suggest that several ingredients of ABR such as Baicalien, Copistine, Epiberberine, Kaempferol, and Palmatine have good affinity with IL6, suggesting the promising potential of ABR in treating bone trauma, likely through IL6. epiberberine 88-100 interleukin 6 Homo sapiens 239-242 33748269-13 2021 The findings also suggest that several ingredients of ABR such as Baicalien, Copistine, Epiberberine, Kaempferol, and Palmatine have good affinity with IL6, suggesting the promising potential of ABR in treating bone trauma, likely through IL6. kaempferol 102-112 interleukin 6 Homo sapiens 152-155 33421881-6 2021 The levels of interleukin (IL)-1beta, IL-6, IL-8 and IL-13 were about 1.5 times higher in the PFOA-treated A549 and L-02 cells than in the controls. perfluorooctanoic acid 94-98 interleukin 6 Homo sapiens 38-42 9378980-6 1997 Stimulation of DNA binding activity to the NF-kappa B and NF-IL-6 binding sites of the IL-6 promoter by asbestos or H2O2 were inhibited by tetramethylthiourea, a hydroxyl radical scavenger. tetramethylthiourea 139-158 interleukin 6 Homo sapiens 61-65 33748269-13 2021 The findings also suggest that several ingredients of ABR such as Baicalien, Copistine, Epiberberine, Kaempferol, and Palmatine have good affinity with IL6, suggesting the promising potential of ABR in treating bone trauma, likely through IL6. kaempferol 102-112 interleukin 6 Homo sapiens 239-242 33748269-13 2021 The findings also suggest that several ingredients of ABR such as Baicalien, Copistine, Epiberberine, Kaempferol, and Palmatine have good affinity with IL6, suggesting the promising potential of ABR in treating bone trauma, likely through IL6. palmatine 118-127 interleukin 6 Homo sapiens 152-155 33748269-13 2021 The findings also suggest that several ingredients of ABR such as Baicalien, Copistine, Epiberberine, Kaempferol, and Palmatine have good affinity with IL6, suggesting the promising potential of ABR in treating bone trauma, likely through IL6. palmatine 118-127 interleukin 6 Homo sapiens 239-242 33748269-13 2021 The findings also suggest that several ingredients of ABR such as Baicalien, Copistine, Epiberberine, Kaempferol, and Palmatine have good affinity with IL6, suggesting the promising potential of ABR in treating bone trauma, likely through IL6. abr 195-198 interleukin 6 Homo sapiens 152-155 33748269-13 2021 The findings also suggest that several ingredients of ABR such as Baicalien, Copistine, Epiberberine, Kaempferol, and Palmatine have good affinity with IL6, suggesting the promising potential of ABR in treating bone trauma, likely through IL6. abr 195-198 interleukin 6 Homo sapiens 239-242 33618152-4 2021 The use of cannabis plus cocaine leads to higher systemic levels of LPS, CRP, IL-6 and higher IL-6/IL-10 ratio, characterizing a proinflammatory profile. Cocaine 25-32 interleukin 6 Homo sapiens 78-82 33618152-4 2021 The use of cannabis plus cocaine leads to higher systemic levels of LPS, CRP, IL-6 and higher IL-6/IL-10 ratio, characterizing a proinflammatory profile. Cocaine 25-32 interleukin 6 Homo sapiens 94-98 10072866-7 1997 RESULTS: Four transfectants, PGTAS1, PGTAS6, PGTAS8, PGTAS9, could express IL-6 antisense mRNA and secret decreased bioactive IL-6. pgtas8 45-51 interleukin 6 Homo sapiens 75-79 33516376-3 2021 A novel quartz crystal microbalance (QCM) immunoassay method was presented for high sensitivity and selectivity detection of interleukin-6 (IL-6) based on gold nanoparticles functionalized sulfur-doped graphene quantum dot (AuNPs/S-GQD) and hollow ZnS-CdS nanocage (h-ZnS-CdS NC). aunps 224-229 interleukin 6 Homo sapiens 125-138 10072866-7 1997 RESULTS: Four transfectants, PGTAS1, PGTAS6, PGTAS8, PGTAS9, could express IL-6 antisense mRNA and secret decreased bioactive IL-6. pgtas8 45-51 interleukin 6 Homo sapiens 126-130 33516376-3 2021 A novel quartz crystal microbalance (QCM) immunoassay method was presented for high sensitivity and selectivity detection of interleukin-6 (IL-6) based on gold nanoparticles functionalized sulfur-doped graphene quantum dot (AuNPs/S-GQD) and hollow ZnS-CdS nanocage (h-ZnS-CdS NC). aunps 224-229 interleukin 6 Homo sapiens 140-144 33968024-8 2021 Thus, bile acids, especially CDCA, may operate to damp inflammation via FXR-mediated downregulation of IL-6 in mononuclear cells and provide a protective mechanism for CP patients. Chenodeoxycholic Acid 29-33 interleukin 6 Homo sapiens 103-107 9150773-0 1997 Preoperative infiltration of bupivacaine--effects on pain relief and trauma response (cortisol and interleukin-6). Bupivacaine 29-40 interleukin 6 Homo sapiens 99-112 33919169-1 2021 Here, we report on the role of haptoglobin (Hp), whose expression depends on the synthesis of interleukin 6 (IL-6), related to the pathogenesis of multiple sclerosis (MS), as a possible marker of muscle improvement achieved after treatment with the polyphenol epigallocatechin gallate (EGCG) and an increase in the ketone body beta-hydroxybutyrate (BHB) in the blood. polyphenol epigallocatechin gallate 249-284 interleukin 6 Homo sapiens 109-113 33205391-12 2021 Importantly, AS101 significantly reduced mRNA levels of pro-inflammatory mediators such as IL-6 (p<0.05) and IL-1beta (p<0.01) in activated primary human fibroblasts. ammonium trichloro(dioxoethylene-O,O'-)tellurate 13-18 interleukin 6 Homo sapiens 91-95 33517195-6 2021 Moreover, we observed a reduction in melanin content via shedding of dendrites, down-regulation of MITF-M, TYR and up-regulation of TNFR1, IL6, ICAM1 expression, whereas TNFR2 levels remain unaltered. Melanins 37-44 interleukin 6 Homo sapiens 139-142 9089795-9 1997 After complete removal of monocytes from cell cultures, there were inhibitory effects of lloprost and PGE2 on IL-6 released in the supernatants. lloprost 89-97 interleukin 6 Homo sapiens 110-114 9086575-6 1997 OSM inhibited iodide uptake stimulated by TSH; while IL-6 also inhibited iodide uptake, it was only about one-tenth as potent. Iodides 73-79 interleukin 6 Homo sapiens 53-57 33653365-7 2021 CONCLUSIONS: It can be concluded, that 6 weeks of supplementation and exercise was too short to obtain significant changes in gene expression in leukocytes, but supplementation of 1000 mg vitamin C positively affected IL-6 and IL-10 expression - which are key changes in the adaptation to training. Ascorbic Acid 188-197 interleukin 6 Homo sapiens 218-222 33602249-11 2021 Based on our data, DHA and Insulin diminished the production of all inflammatory cytokines, TNF-alpha, IL-6, and NF-kappaB, in palmitic-treated cells (p < 0.05). palmitic 127-135 interleukin 6 Homo sapiens 103-107 33595099-8 2021 CLR for heparan sulfate increased with interleukin-6 (P< 0.003) and the urine flow (P< 0.01). Heparitin Sulfate 8-23 interleukin 6 Homo sapiens 39-52 8978296-0 1997 Interleukin-6 inhibits Fas-induced apoptosis and stress-activated protein kinase activation in multiple myeloma cells. ammonium ferrous sulfate 23-26 interleukin 6 Homo sapiens 0-13 33248001-8 2021 We hypothesise that CYP3A5 non-expressors might exhibit a temporary decrease in the oral clearance of tacrolimus via an increase in serum IL-6 concentrations early after kidney transplantation. Tacrolimus 102-112 interleukin 6 Homo sapiens 138-142 8914271-3 1996 A combination of 13C-chemical shift, amide hydrogen-bond exchange, and 15N-edited NOESY data allowed for analysis of the secondary structure of IL-6. 15n 71-74 interleukin 6 Homo sapiens 144-148 8795300-9 1996 It is possible that rIFN-alpha therapy could be associated with an inhibitory effect of rIFN-alpha on the release of IL-6 from damaged thyroid cells and not on the basal secretion of IL-6. rifn-alpha 20-30 interleukin 6 Homo sapiens 117-121 33249645-10 2021 Furthermore, significantly higher expression of the pro-inflammatory cytokines IL-6 and IL-8 is detected after FLS cells interacted with NETs which derived from neutrophils stimulated with ACPA-containing IgG antibodies. arachidonylcyclopropylamide 189-193 interleukin 6 Homo sapiens 79-83 32363436-6 2021 In addition, CMBL5-LO inhibited several chemo-attractants, including interleukin (IL)-6, macrophage inflammatory protein (MIP)-2, chemokine (C-C motif) ligand 5 (CCL5), granulocyte colony-stimulating factor (GCSF), and monocyte chemoattractant protein-1 (MCP-1) expression. cmbl5-lo 13-21 interleukin 6 Homo sapiens 69-87 8812622-5 1996 High dose of fentanyl anesthesia reduced cortisol levels during the surgery (CA 38.0 +/- 13.8 pg/ml vs FA 13.5 +/- 2.4, P < 0.05) and interleukin-6 levels in the plasma after the surgery (P < 0.02). Fentanyl 13-21 interleukin 6 Homo sapiens 137-150 33503825-10 2021 Fedratinib inhibited the expression of LIF, SOCS3, RRAD, NOTCH3, TNF, COMP, THBS2, and IL6, which are associated with various signalling pathways, including TGFbeta signalling, insulin signalling, focal adhesion, Notch Signalling, IL-6 signalling, endochondral ossification, TNF-alpha, and cytokines and inflammatory response. Fedratinib 0-10 interleukin 6 Homo sapiens 87-90 33503825-10 2021 Fedratinib inhibited the expression of LIF, SOCS3, RRAD, NOTCH3, TNF, COMP, THBS2, and IL6, which are associated with various signalling pathways, including TGFbeta signalling, insulin signalling, focal adhesion, Notch Signalling, IL-6 signalling, endochondral ossification, TNF-alpha, and cytokines and inflammatory response. Fedratinib 0-10 interleukin 6 Homo sapiens 231-235 33285354-6 2021 The highest levels of IL-1beta, IL-6, CCL2 and IL-8 were observed with MSU at 0.5 mg/ml, CPP at 0.01-0.05 mg/ml and BCP at 1 mg/ml after 18-48 h and then decreased. Uric Acid 71-74 interleukin 6 Homo sapiens 32-36 33431967-8 2021 Correcting medium acidification with NaOH inhibited the CO2-induced suppression of TNFalpha and IL-6 expression in keratinocytes. Sodium Hydroxide 37-41 interleukin 6 Homo sapiens 96-100 33142636-5 2021 Three NPs greatly promoted the expression and secretion of interleukin-6 (IL-6), tumor necrosis factor (TNF-alpha), and interleukin-1beta (IL-1beta) in DC cells: C2,3,6 chitosan sulfate-HACC (C2,3,6-HACC; 200 kDa), C3,6 chitosan sulfate-HACC (C3,6-HACC; 200 kDa) and C6 chitosan sulfate-HACC (C6-HACC; 50 kDa). c2,3,6-hacc 192-203 interleukin 6 Homo sapiens 59-72 33325084-9 2021 Cytokine measurement pre- and post-PMX-DHP revealed decreased levels of interleukin-6 and the factors involved in vascular endothelial injury, including vascular endothelial growth factor. 1,4-dihydropyridine 39-42 interleukin 6 Homo sapiens 72-85 8688318-7 1996 In order to transfer these data to tumour cells constitutively expressing stress hsp70 due to the constitutive activity of the original hsp70 promoter we sought to supress the heat shock response pathway by the natural flavonoid quercetin, known to inactivate the heat shock transcription factor (HSF). Quercetin 229-238 interleukin 6 Homo sapiens 264-295 33520015-11 2020 Finally, 6 key proteins of TNF, IL-10, IL-2, IL-6, STAT1 and CCL2 were selected and successfully docked with 4 active ingredients of quercetin, luteolin, wogonin and kaempferol. kaempferol 166-176 interleukin 6 Homo sapiens 45-49 33200478-0 2021 Role of IL-6 and STAT3 signaling in dihydropyridine-induced gingival overgrowth fibroblasts. 1,4-dihydropyridine 36-51 interleukin 6 Homo sapiens 8-12 33200478-8 2021 CONCLUSIONS: Gingival inflammation (e.g., IL-1beta) and taking dihydropyridine (e.g., Nif) may additively stimulate Col overproduction through the IL-6-STAT3-Colalpha1(I) cascade in DIGO cells. 1,4-dihydropyridine 63-78 interleukin 6 Homo sapiens 147-151 30554535-2 2021 Administration of gastrodin can relieve chronic pain to cancer patients with CIPN and attenuated the inflammatory response by reducing the expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). gastrodin 18-27 interleukin 6 Homo sapiens 197-210 30554535-2 2021 Administration of gastrodin can relieve chronic pain to cancer patients with CIPN and attenuated the inflammatory response by reducing the expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). gastrodin 18-27 interleukin 6 Homo sapiens 212-216 32148148-0 2021 Uric acid-mediated inflammasome activation in IL-6 primed innate immune cells is regulated by baricitinib. Uric Acid 0-9 interleukin 6 Homo sapiens 46-50 8688318-7 1996 In order to transfer these data to tumour cells constitutively expressing stress hsp70 due to the constitutive activity of the original hsp70 promoter we sought to supress the heat shock response pathway by the natural flavonoid quercetin, known to inactivate the heat shock transcription factor (HSF). Quercetin 229-238 interleukin 6 Homo sapiens 297-300 32148148-8 2021 Pretreatment with baricitinib, which blocks IL-6 receptor signalling, prevented MSU-induced cleaved caspase-1 or IL-1beta induction in IL-6-primed neutrophils. Uric Acid 80-83 interleukin 6 Homo sapiens 44-48 8635282-7 1996 These results show that only SA AM and AFb secrete high levels of IL-6 which have suppressive effect on AFb proliferation. sa am 29-34 interleukin 6 Homo sapiens 66-70 32148148-9 2021 Tocilizumab pretreatment also inhibited MSU-mediated IL-1beta production from IL-6-primed neutrophilsConclusions: Priming of human neutrophils with IL-6 promotes uric acid-mediated IL-1beta secretion in the absence of microbial stimulation. Uric Acid 162-171 interleukin 6 Homo sapiens 148-152 32961186-7 2020 Bj5-ta cells stimulated with liposaccharides (LPS), presented a reduction of 86% on IL-6 cytokine levels, after exposure to chitosan with 5% EtPUAE film extract. liposaccharides 29-44 interleukin 6 Homo sapiens 84-88 32961186-7 2020 Bj5-ta cells stimulated with liposaccharides (LPS), presented a reduction of 86% on IL-6 cytokine levels, after exposure to chitosan with 5% EtPUAE film extract. Chitosan 124-132 interleukin 6 Homo sapiens 84-88 8621406-0 1996 A di-leucine motif and an upstream serine in the interleukin-6 (IL-6) signal transducer gp130 mediate ligand-induced endocytosis and down-regulation of the IL-6 receptor. di-leucine 2-12 interleukin 6 Homo sapiens 49-62 33204288-12 2020 Molecular docking showed that quercetin, kaempferol, baicalein, and wogonin have good binding activity with IL6, VEGFA, EGFR, and NFKBIA targets. kaempferol 41-51 interleukin 6 Homo sapiens 108-111 8621406-0 1996 A di-leucine motif and an upstream serine in the interleukin-6 (IL-6) signal transducer gp130 mediate ligand-induced endocytosis and down-regulation of the IL-6 receptor. di-leucine 2-12 interleukin 6 Homo sapiens 64-68 33225149-11 2020 THP-1 macrophages co-treated with WWL113 and PGD2-G prior to stimulation with lipopolysaccharide exhibited a more pronounced attenuation of pro-inflammatory cytokine levels (interleukin-6 and TNFalpha) than by PGD2-G treatment alone. wwl113 34-40 interleukin 6 Homo sapiens 174-187 8621406-0 1996 A di-leucine motif and an upstream serine in the interleukin-6 (IL-6) signal transducer gp130 mediate ligand-induced endocytosis and down-regulation of the IL-6 receptor. di-leucine 2-12 interleukin 6 Homo sapiens 156-160 32784000-6 2020 Moreover, CB08035-SCA and CB08035-SYP treatments reduced significantly Bax, BNIP3, APAF1, ERK1, JNK1, MAPK1, NFkappaB1, TNFalpha, IL-6, IL-1beta and HO-1 gene expressions of apoptosis, proinflammation and oxidative stress induced by t-BOOH. SMSF0006723 10-17 interleukin 6 Homo sapiens 130-134 8833207-0 1996 Interleukin-6 and tumor necrosis factor alpha levels after bisphosphonates treatment in vitro and in patients with malignancy. Diphosphonates 59-74 interleukin 6 Homo sapiens 0-45 32784000-6 2020 Moreover, CB08035-SCA and CB08035-SYP treatments reduced significantly Bax, BNIP3, APAF1, ERK1, JNK1, MAPK1, NFkappaB1, TNFalpha, IL-6, IL-1beta and HO-1 gene expressions of apoptosis, proinflammation and oxidative stress induced by t-BOOH. SMSF0006723 26-33 interleukin 6 Homo sapiens 130-134 33139632-6 2020 Vadadustat caused a marked decrease in the secretion of IL6 (by 51%), HGF (by 47%), CCL7 (MCP3) (by 42%) and CXCL8 (by 40%). vadadustat 0-10 interleukin 6 Homo sapiens 56-59 9816167-3 1996 Retinoids also inhibit in vitro growth of human cancer cells and decrease IL-6 receptor display and autosecretion by some myeloma cells. Retinoids 0-9 interleukin 6 Homo sapiens 74-78 8548766-4 1996 Because quercetin was shown to modulate hsp70 expression after heat shock in K562 cells, we have investigated the effect of this flavonoid on HSF activation, hsp70 synthesis, and thermotolerance in human K562 cells after induction with PGA1. Flavonoids 129-138 interleukin 6 Homo sapiens 142-145 32505533-12 2020 Furthermore, ICC cell-derived exosomal miR-9-5p elicited a high expression of IL-6 in vCAFs to promote tumor progression. mir-9-5p 39-47 interleukin 6 Homo sapiens 78-82 32458591-7 2020 Furthermore, in vitro experiments demonstrate that DAMA stimulates cell proliferation, cell migration, secretion of collagen type I, and the reduction of pro-inflammatory cytokines IL-1beta, IL-6, and TNF-alpha. diethyl thiophosphoryl (Z)-(2-aminothiazol-4-yl)methoxyimino acetate 51-55 interleukin 6 Homo sapiens 191-195 8536717-16 1995 Intravenously injected soluble 125I-labeled IL-6 receptor, as well as complexes with IL-6, rapidly accumulated in liver and to a lesser extent in skeletal muscle, skin and kidneys. Iodine-125 31-35 interleukin 6 Homo sapiens 44-48 32818918-9 2020 Among cannabinoid-positive participants, IL-6 levels negatively correlated with PANSS total score (p = 0.040), as well as positive (p = 0.035) and negative (p = 0.024) subscales. Cannabinoids 6-17 interleukin 6 Homo sapiens 41-45 33276365-2 2020 Hsp70 and GYY4137 have been shown to significantly reduce LPS-induced production of inflammatory mediators by SH-SY5Y cells, including reactive oxygen species, nitric oxide, TNFalpha, IL-1beta, and IL-6. GYY 4137 10-17 interleukin 6 Homo sapiens 198-202 32712091-7 2020 In addition, the expression of inflammatory factors, including interleukin-1beta (IL-lbeta), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) were decreased by 100 muM daidzein (73.8% +- 5.3%, 58.8 +- 9.0% and 55.5% +- 7.2%, respectively) in LPS-treated hepatocytes. daidzein 184-192 interleukin 6 Homo sapiens 93-106 32712091-7 2020 In addition, the expression of inflammatory factors, including interleukin-1beta (IL-lbeta), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) were decreased by 100 muM daidzein (73.8% +- 5.3%, 58.8 +- 9.0% and 55.5% +- 7.2%, respectively) in LPS-treated hepatocytes. daidzein 184-192 interleukin 6 Homo sapiens 108-112 33019824-9 2021 Piperlongumine-treated MDA-MB-231 cells showed reduced motility/invasiveness, decreased MMP2 and MMP9 expression, increased miR-200c expression, reduced IL-6 synthesis, decreased expression of ZEB1 and Slug, increased E-cadherin expression, and epithelial-like morphology. piperlonguminine 0-14 interleukin 6 Homo sapiens 153-157 7592665-4 1995 Because it is not known how HSF enhances heat shock gene expression, further analysis of the transcriptionally inert, salicylate-induced HSF was undertaken to potentially identify components of the heat shock response that are necessary for full transcriptional induction. Salicylates 118-128 interleukin 6 Homo sapiens 137-140 33057114-10 2020 Considering different chemical forms of vitamin E, alpha-tocopherol, unlike other forms, had a reducing effect on serum levels of CRP and IL-6. alpha-Tocopherol 51-67 interleukin 6 Homo sapiens 138-142 8848900-0 1995 Increase of interleukin-6 plasma concentrations and HLA-DR positive T-lymphocytes after hypotensive anaesthesia with sodium nitroprusside. Nitroprusside 117-137 interleukin 6 Homo sapiens 12-25 31965901-8 2020 These results revealed the essential role of autophagy in endothelial cell integrity and revealed that the disruption of endothelial autophagy could lead to significant pathological IL6-dependent EndMT and organ fibrosis.Abbreviations: 3-MA: 3-methyladenine; ATG5: autophagy related 5; EndMT: endothelial-to-mesenchymal transition; HES: hematoxylin and eosin stain; HFD: high-fat diet; HMVECs: human microvascular endothelial cells; IFNG: interferon gamma; IL6: interleukin 6; MTS: Masson"s trichrome staining; NFD: normal-fat diet; siRNA: small interfering RNA; SMAD3: SMAD family member 3; TGFB: transforming growth factor beta; TNF: tumor necrosis factor; VEGFA: vascular endothelial growth factor A. Hematoxylin 337-348 interleukin 6 Homo sapiens 182-185 32856282-10 2020 Median (interquartile range) darunavir CL/F was significantly lower in SARS-CoV-2 patients with IL-6 levels >= 18 pg/mL than in SARS-CoV-2 patients with IL-6 levels < 18 pg/mL or HIV patients (2.78 [2.16-4.47] vs. 7.24 [5.88-10.38] vs. 9.75 [8.45-13.79] L/h, respectively; p < 0.0001). darunavir cl 29-41 interleukin 6 Homo sapiens 96-100 32479111-9 2020 Blood measures of IL-6, but not eosinophils, were significantly associated with EPA, and IL-6 and eosinophils predicted exacerbations in the sample as a whole. Eicosapentaenoic Acid 80-83 interleukin 6 Homo sapiens 18-22 32856282-9 2020 CART analysis found that an IL-6 level of 18 pg/mL may split the SARS-CoV-2 population in patients with low versus high darunavir CL/F (mean +- standard deviation 3.47 +- 1.90 vs. 8.03 +- 3.24 L/h; proportion of reduction in error = 0.46). darunavir cl 120-132 interleukin 6 Homo sapiens 28-32 8673868-5 1995 Incubation of osteoblasts with conditioned medium from macrophages exposed to PMMA particles led to release of GM-CSF, IL-6, and PGE-2. Polymethyl Methacrylate 78-82 interleukin 6 Homo sapiens 119-123 32783763-6 2020 CBNPs induced a significant increase in the expressions of IL-8 and IL-6, accompanied by a high level of intracellular HDAC6 mRNA when compared with a blank control group (p < 0.05). cbnps 0-5 interleukin 6 Homo sapiens 68-72 32526241-7 2020 BBM treatment reduced the oxidative burst and pro-inflammatory responses by significantly enhancing hepatic antioxidant defenses [SOD (P < 0.001), catalase (P < 0.001) and cellular glutathione (P < 0.01)] and diminishing NF-kappaB regulated proinflammatory cytokines (TNF-alpha, and IL-6) levels respectively. berbamine 0-3 interleukin 6 Homo sapiens 283-287 33230450-7 2020 Mechanically, miR-146b-5p suppressed nuclear factor kappaB (NF-kappaB) activity and NF-kappaB-related IL-6 and IL-8 production by targeting IRAK1. mir-146b-5p 14-25 interleukin 6 Homo sapiens 102-106 8673868-7 1995 Our data demonstrate that exposure of macrophages to PMMA particles leads to the release of TNF which then stimulates osteoblasts to produce GM-CSF, IL-6 and PGE-2. Polymethyl Methacrylate 53-57 interleukin 6 Homo sapiens 149-153 8785878-21 1995 If a genetic defect decreases the affinity of a suppressive receptor/ligand complex for the regulatory element of IL-6 or TGF-alpha, for example, then these cells could be relatively resistant to homeostatic regulation by indigenous corticosteroids, vitamin D, and retinoids. Retinoids 265-274 interleukin 6 Homo sapiens 114-118 33013880-11 2020 The fold decrease in plasma IL-6 was significantly less in the 4 g TXA group [1.36 (0.87-2.42)] compared to the placebo group [0.46 (0.19-1.69)] at 72 h post-TXA (p = 0.028). Tranexamic Acid 67-70 interleukin 6 Homo sapiens 28-32 33013880-11 2020 The fold decrease in plasma IL-6 was significantly less in the 4 g TXA group [1.36 (0.87-2.42)] compared to the placebo group [0.46 (0.19-1.69)] at 72 h post-TXA (p = 0.028). Tranexamic Acid 158-161 interleukin 6 Homo sapiens 28-32 32561292-6 2020 Peficitinib inhibited STAT3 phosphorylation in RA-FLS following induction by interferon (IFN)-alpha2b, IFN-gamma, interleukin (IL)-6, oncostatin M, and leukemia inhibitory factor in a concentration-related manner, and was comparable to approved JAK inhibitors, tofacitinib and baricitinib. peficitinib 0-11 interleukin 6 Homo sapiens 114-132 8589669-1 1995 Five high molecular weight glycolipids capable of stimulating human peripheral whole-blood cell cultures to cause interleukin 6 (IL-6) and tumor necrosis factor (TNF)-alpha induction were isolated from one of the lipoteichoic acid fractions (LTA-2) extracted from Enterococcus hirae ATCC 9790 (Tsutsui et al., (1991) FEMS Microbiol. lipoteichoic acid 213-230 interleukin 6 Homo sapiens 129-133 32412821-6 2020 At a dose of 50 muM, the most effective dose, Kaempferol also inhibited protein levels of tumor necrosis factor alpha and interleukin-6, nuclear activity and protein levels of total, acetylated, and cleaved PARP1, and increased nuclear levels and activity of SIRT1 in H2O2-treated cells. kaempferol 46-56 interleukin 6 Homo sapiens 122-135 31907823-8 2020 RESULTS: The results showed that AS-IV significantly reduced the levels of ROS, LDH, MDA, IL-8, IL-1beta, and IL-6, and increased the level of SOD in intermittent hypoxia-induced Beas-2B cells. astragaloside A 33-38 interleukin 6 Homo sapiens 110-114 7629516-8 1995 Both D-erythro-C2-ceramide (a cell-permeable analogue of natural ceramide) and D-threo-C2-ceramide were potent inducers of IL-6 production, while neither L isomer of ceramide was effective. d-threo-c2-ceramide 79-98 interleukin 6 Homo sapiens 123-127 32470481-6 2020 IL-6 mean concentration was significantly higher in the repetitive TBI group compared to those with 1-2 TBI or no TBI history (p = 0.050). tbi 67-70 interleukin 6 Homo sapiens 0-4 32506039-6 2020 In human epidermal reconstructs a topical use-relevant DHA-dose regimen elicited a comparable stress response as revealed by gene expression array (HSPA1A, HSPA6, HSPD1, IL6, DDIT3, EGR1) and immunohistochemical analysis (CEL, HO-1, p-Hsp27-S78). Dihydroxyacetone 55-58 interleukin 6 Homo sapiens 170-173 32464779-4 2020 Urinary metabolites of PAHs (i.e., OH-PAHs), measured as indicators of total PAH exposure, showed significant associations with markers of respiratory and systemic inflammation, including exhaled nitric oxide, interleukin (IL)-6 in exhaled breath condensate, and blood IL-2 and IL-8 levels and leucocyte count. oh-pahs 35-42 interleukin 6 Homo sapiens 210-228 32609359-10 2020 SOL-DMSCs showed reduced proliferation and increased lipid peroxidation, migration, necrosis, mitochondrial apoptosis, IL-6 production and p38 MAPK levels compared with NIL-DMSCs (p < 0.05). dmscs 4-9 interleukin 6 Homo sapiens 119-123 32629602-12 2020 The specific value of p-JAK2/JAK2 and p-STAT3/STAT3 protein relative expressions in IL-6 group were significantly higher than those in control group (both P<0.05), the specific value of p-JAK2/JAK2 and p-STAT3/STAT3 protein relative expressions in simvastatin (20, 40 mg/L) combined with IL-6 groups were lower than those in IL-6 group (all P<0.05), respectively. Simvastatin 248-259 interleukin 6 Homo sapiens 84-88 7539384-10 1995 Evidence for autocrine regulation of this cell line by IL-6 was demonstrated by the inhibitory effects of an antisense oligonucleotide on 3H-thymidine (3H-TdR) incorporation. 3h-thymidine 138-150 interleukin 6 Homo sapiens 55-59 7664978-3 1995 We incubated adrenal cells with 50 pM 125I-labeled TGF-beta 1 for 15 min to 3 h at 4 degree C and found that the binding of 125I-labeled TGF-beta 1 increased with time and could be inhibited in a dose-dependent manner by non-labeled TGF-beta 1 (0.05-10 nM), but not with other relevant cytokines: IL6, TNF alpha,IGF-I, IGF-II, TGF-alpha, and EGF. Iodine-125 38-42 interleukin 6 Homo sapiens 297-300 32537016-6 2020 In vitro, the results demonstrated that baicalin clearly inhibited the release of TNF-alpha, IL-6 and IL-1beta and promoted the expression of IL-10 in LPS-induced HT-29 cells, and significantly decreased LPS-induced HT-29 cell apoptosis by blockage of the PI3K/AKT signaling pathway. baicalin 40-48 interleukin 6 Homo sapiens 93-97 32415642-7 2020 The IL-6 concentration in D5-NTQ or D6-TQ SBCM was higher than that in D5-TQ or D6-NTQ SBCM (P < 0.05), respectively. d5-ntq 26-32 interleukin 6 Homo sapiens 4-8 32802081-13 2020 Captopril increased IL-8 from stroke-Mo and increased IL-6, IL-8, and MCP-1 secretions from MSCs. Captopril 0-9 interleukin 6 Homo sapiens 54-58 32802081-14 2020 Captopril also increased IL-6 secretion from cocultures of stroke-Mo and MSCs indicating a strong proinflammatory effect on MSCs and their interaction with Mo. Captopril 0-9 interleukin 6 Homo sapiens 25-29 32802081-15 2020 Atenolol increased the secretion of IL-8 and MCP-1 while captopril increased the secretion of IL-6 and MCP-1 from MSCs. Captopril 57-66 interleukin 6 Homo sapiens 94-98 32415642-7 2020 The IL-6 concentration in D5-NTQ or D6-TQ SBCM was higher than that in D5-TQ or D6-NTQ SBCM (P < 0.05), respectively. d6-ntq 80-86 interleukin 6 Homo sapiens 4-8 7702609-2 1995 After treatment of cells with nonlethal concentrations of quercetin, the binding of heat shock factor (HSF) to the heat shock element (HSE) was inhibited as detected by gel shift assay. Quercetin 58-67 interleukin 6 Homo sapiens 84-101 32726040-6 2020 It revealed that the potential efficacy markers of Lonicerae Japonicae Flos in heat-clearing and detoxifying effect based on IL-1 signaling pathway were chlorogenic acid and linalool, and the potential efficacy markers of Lonicerae Japonicae Flos in heat-clearing and detoxifying effect based on IL-6 signaling pathway were chlorogenic acid and luteolin. lonicerae japonicae 51-70 interleukin 6 Homo sapiens 296-300 32792954-5 2020 Furthermore, kaempferol suppressed the levels of TNF-alpha and IL-6, and the activation of NF-kappaB, in aortic tissues and human umbilical vein endothelial cells (HUVECs). kaempferol 13-23 interleukin 6 Homo sapiens 63-67 7702609-2 1995 After treatment of cells with nonlethal concentrations of quercetin, the binding of heat shock factor (HSF) to the heat shock element (HSE) was inhibited as detected by gel shift assay. Quercetin 58-67 interleukin 6 Homo sapiens 103-106 7702609-3 1995 We examined whether quercetin inhibits heat shock response by inhibiting HSF trimer-formation and found it was not the case. Quercetin 20-29 interleukin 6 Homo sapiens 73-76 31036393-11 2020 CONCLUSION: Plant derived essential oils and related active compounds have potential therapeutic activity for the treatment of asthma by modulating the release of pro-inflammatory (TNF-alpha, IL-1beta, IL-8), Th17 (IL-17), anti-inflammatory (IL-10), Th1 (IFN-gamma, IL-2, IL-12) and Th2 (IL-4, IL-5, IL-6, IL-13) cytokines and the suppression of inflammatory cell accumulation. Oils, Volatile 26-40 interleukin 6 Homo sapiens 300-304 32173467-0 2020 Transcripts 202 and 205 of IL-6 confer resistance to Vemurafenib by reactivating the MAPK pathway in BRAF(V600E) mutant melanoma cells. Vemurafenib 53-64 interleukin 6 Homo sapiens 27-31 32173467-11 2020 Neutralizing IL-6 significantly increased the sensitivity of drug-resistant cells to Vemurafenib. Vemurafenib 85-96 interleukin 6 Homo sapiens 13-17 32537016-5 2020 In the present study, the results revealed that baicalin not only significantly alleviated TNBS-induced colitis by reducing the release of IL-6, TNF-alpha and IL-1beta and increasing the level of IL-10, but promoted the expression of tight-junction proteins ZO-1 and beta-catenin, which may have been achieved by blockage of the PI3K/AKT signaling pathway. baicalin 48-56 interleukin 6 Homo sapiens 139-143 7829234-8 1995 In the absence of stimuli, TAM produced higher levels, compared to monocytes, of IL-6 and IL-8 but not of IL-1 and TNF. tam 27-30 interleukin 6 Homo sapiens 81-85 32059850-3 2020 Both the in vitro and in vivo results clearly showed that YDWPGGRN significantly inhibited the LPS-stimulated NO, IL-1beta, IL-6 and TNF-alpha production but promoted the release of an anti-inflammatory cytokine, IL-10. ydwpggrn 58-66 interleukin 6 Homo sapiens 124-128 7851440-3 1995 Mutant interleukin-6 was solubilized in 6 M guanidine hydrochloride, subjected to oxidative refolding and purified to homogeneity by ammonium sulfate precipitation and hydrophobic chromatography. Ammonium Sulfate 133-149 interleukin 6 Homo sapiens 7-20 32550737-1 2020 Objective: We aimed to evaluate the relation between plasma ascorbic acid levels and the occurrence of preterm premature rupture of membranes (PPROM) and whether patients with ascorbic acid deficiency have predisposition to microbial invasion, as revealed by serum interleukin-6 (IL-6) levels and confirmed by placental culture sensitivity evaluation. Ascorbic Acid 176-189 interleukin 6 Homo sapiens 265-278 8597871-3 1995 In this cell line Fas mobilizes the p50/p65 heterodimeric form of NF-kappa B and induces interleukin-6 (IL-6) production. ammonium ferrous sulfate 18-21 interleukin 6 Homo sapiens 89-102 32058033-9 2020 EPA and DHA also significantly lowered production of monocyte chemoattractant protein 1, interleukin (IL)-6 and IL-8. Eicosapentaenoic Acid 0-3 interleukin 6 Homo sapiens 89-107 32326546-6 2020 Among patients with CF, IL-6 and IL-8 were significantly higher in patients with NTH, while TNF-alpha was significantly lower in patients with NP. SUCCINIC ACID MONO-(13-METHYL-3-OXO-2,3,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL) ESTER 81-84 interleukin 6 Homo sapiens 24-28 8597871-3 1995 In this cell line Fas mobilizes the p50/p65 heterodimeric form of NF-kappa B and induces interleukin-6 (IL-6) production. ammonium ferrous sulfate 18-21 interleukin 6 Homo sapiens 104-108 32077347-10 2020 Parecoxib could significantly reduce the concentrations of IL-6 but results regarding the changes in TNF-alpha, CRP, and S100beta levels remained inconsistent. parecoxib 0-9 interleukin 6 Homo sapiens 59-63 8087861-6 1994 However, zidovudine could be directly contributing to lymphoma-genesis in HIV-infected individuals, perhaps by enhancing B cell activation, since B cell hyperactivation and elevated levels of IL-6, a B cell stimulatory cytokine, are seen in HIV infection. Zidovudine 9-19 interleukin 6 Homo sapiens 192-196 32308723-6 2020 The results showed that 5 selected polysaccharides, except BBPS, significantly (P < 0.05) and dose-dependently increased M1 (IL-1beta + IL-6 + TNF-alpha)/M2 (IL-10) cytokine secretion ratios by macrophages in the absence of LPS, suggesting that four selected polysaccharides have M1 polarization property. 4-boronic acid benzophenone 59-63 interleukin 6 Homo sapiens 136-140 32179246-4 2020 Our results indicate that alogliptin treatment ameliorated IL-1beta-induced production of reactive oxygen species, the expression of matrix metalloproteinase-3 (MMP-3) and MMP-13, secretions of tumor necrosis factor-alpha (TNF-alpha), IL-6, and IL-8. alogliptin 26-36 interleukin 6 Homo sapiens 235-239 32374474-5 2020 In the present study, silvestrol down-regulated several pro- and anti-inflammatory cytokines (IL-6, IL-8, IL-10, CCL2, CCL18) and increased TNF-alpha during differentiation and activation of M1-macrophages, suggesting that the effects of silvestrol might cancel each other out. silvestrol 22-32 interleukin 6 Homo sapiens 94-98 31943384-7 2020 The expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) that stimulated by wear particles were significantly reduced by GYY4137. GYY 4137 178-185 interleukin 6 Homo sapiens 93-106 7914751-5 1994 Addition of exogenous AZA, 6-mercaptopurine (6-MP), and MTX to the IL-6 bioassay resulted in a dose-dependent inhibition of the B9 cell proliferation induced by IL-6, AZA being most potent on a molar basis. Methotrexate 56-59 interleukin 6 Homo sapiens 67-71 31943384-7 2020 The expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) that stimulated by wear particles were significantly reduced by GYY4137. GYY 4137 178-185 interleukin 6 Homo sapiens 108-112 31802418-12 2020 Treatment with RK-33 inhibits the Tat and cocaine-dependent increase in the number and size of microglia and the proinflammatory cytokines IL-6, TNF-alpha, MCP-1/CCL2, MIP-2, IL-1alpha and IL-1beta. Cocaine 42-49 interleukin 6 Homo sapiens 139-143 7914751-5 1994 Addition of exogenous AZA, 6-mercaptopurine (6-MP), and MTX to the IL-6 bioassay resulted in a dose-dependent inhibition of the B9 cell proliferation induced by IL-6, AZA being most potent on a molar basis. Methotrexate 56-59 interleukin 6 Homo sapiens 161-165 8258686-4 1993 Our study demonstrated that IL-2, IL-4, and IL-6-stimulation of IgM secretion by SKW6.4 cells was inhibited by either the serine/threonine kinase inhibitor, 1-(5-isoquinolinesulfonyl)-2-methylpiperizine dihydrochloride (H7) or the tyrosine kinase inhibitor, genistein. 1-(5-isoquinolinesulfonyl)-2-methylpiperizine dihydrochloride 157-218 interleukin 6 Homo sapiens 44-48 32027356-0 2020 Fingolimod inhibits proliferation and epithelial- mesenchymal transition in sacral chordoma by inactivating IL-6/STAT3 signaling. fingolimod 0-10 interleukin 6 Homo sapiens 108-112 8099121-9 1993 For patients receiving AZT-based therapy, pretreatment serum interleukin-6 (IL-6) levels were somewhat higher in those who subsequently developed NHL than in those who did not (P2 = .048). Zidovudine 23-26 interleukin 6 Homo sapiens 61-74 32121312-6 2020 Risperidone and haloperidol both reduced the levels of IL-1alpha, IL-1beta, IL-2, and IL-17, and increased the levels of IL-6, IL-10, INF-gamma, and TNF-alpha. Haloperidol 16-27 interleukin 6 Homo sapiens 121-125 32198705-7 2020 Pinitol suppresses the expression and secretion of pro-inflammatory cytokines such as TNF-alpha, IL-1beta, and IL-6. pinitol 0-7 interleukin 6 Homo sapiens 111-115 8099121-9 1993 For patients receiving AZT-based therapy, pretreatment serum interleukin-6 (IL-6) levels were somewhat higher in those who subsequently developed NHL than in those who did not (P2 = .048). Zidovudine 23-26 interleukin 6 Homo sapiens 76-80 7678052-4 1993 These elements contain a characteristic hexanucleotide motif, CTGGGA, known to be required for the IL-6 responsiveness of these genes. hexanucleotide 40-54 interleukin 6 Homo sapiens 99-103 32485858-0 2020 Javamide-II Inhibits IL-6 without Significant Impact on TNF-alpha and IL-1beta in Macrophage-Like Cells. javamide-ii 0-11 interleukin 6 Homo sapiens 21-25 32485858-2 2020 In this study, the potential effects of javamide-II on IL-6, IL-1beta and TNF-alpha productions were determined using their ELISA kits in macrophage-like THP-1 cells. javamide-ii 40-51 interleukin 6 Homo sapiens 55-59 32485858-4 2020 At concentrations of 0.2-40 microM, javamide-II inhibited IL-6 production significantly in the THP-1 cells (IC50 of 0.8 microM) (P < 0.02). javamide-ii 36-47 interleukin 6 Homo sapiens 58-62 32485858-8 2020 The data indicate that javamide-II may be a potent compound to inhibit IL-6 production via suppressing the p38 signal pathway, without significant effects on the productions of TNF-alpha and IL-1beta in macrophage-like THP-1 cells. javamide-ii 23-34 interleukin 6 Homo sapiens 71-75 32120344-6 2020 Of interest, we observed that 1alpha,25(OH)2D3 inhibits NF-kappaB activation and subsequent synthesis and secretion of IL-6 and IL-8 by promoting VDR and NF-kappaB p65 interaction. 25(oh)2d3 37-46 interleukin 6 Homo sapiens 119-123 32057253-3 2020 The levels of cytokine and chemokine were analysed with ELISA and real-time PCR.Results: Astragaloside IV significantly inhibited the levels of CCL5, MCP-1, IL-6 and IL-8. astragaloside A 89-102 interleukin 6 Homo sapiens 157-161 1321338-0 1992 Inhibition of the activation of heat shock factor in vivo and in vitro by flavonoids. Flavonoids 74-84 interleukin 6 Homo sapiens 32-49 32043302-7 2020 Interferon regulatory factor-driven and NFkappaB-driven responses following TLR7 stimulation were enhanced by OMN (increases in IL-6, IL-10, MXA, and IFNgamma), and more immune cell infiltration was observed (in particular CD4+, CD8+, and CD14+ cells). omiganan pentahydrochloride 110-113 interleukin 6 Homo sapiens 128-132 1321338-6 1992 Treatment with quercetin inhibited the binding of HSF to the HSE in whole-cell extracts activated in vivo by heat shock and in cytoplasmic extracts activated in vitro by elevated temperature or by urea. Quercetin 15-24 interleukin 6 Homo sapiens 50-53 1321338-7 1992 The binding of HSF activated in vitro by Nonidet P-40 was not suppressed by the addition of quercetin. Nonidet P-40 41-53 interleukin 6 Homo sapiens 15-18 32013615-5 2022 APAP significantly (p < 0.05) increased blood levels of urea, creatinine, malondialdehyde (MDA), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha), which were effectively reduced by RES + QUR. Acetaminophen 0-4 interleukin 6 Homo sapiens 100-113 1321338-8 1992 The formation of the HSF-HSE complex was not inhibited when quercetin was added only during the binding reaction of HSF to the HSE after in vitro heat activation. Quercetin 60-69 interleukin 6 Homo sapiens 21-24 32013615-5 2022 APAP significantly (p < 0.05) increased blood levels of urea, creatinine, malondialdehyde (MDA), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha), which were effectively reduced by RES + QUR. Acetaminophen 0-4 interleukin 6 Homo sapiens 115-119 1321338-8 1992 The formation of the HSF-HSE complex was not inhibited when quercetin was added only during the binding reaction of HSF to the HSE after in vitro heat activation. Quercetin 60-69 interleukin 6 Homo sapiens 116-119 32382617-7 2020 For more insight please see Transcripts 202 and 205 of IL-6 confer resistance to Vemurafenib by reactivating the MAPK pathway in BRAF(V600E) mutant melanoma cells [1]. Vemurafenib 81-92 interleukin 6 Homo sapiens 55-59 1321338-9 1992 Quercetin thus interacts with HSF and inhibits the induction of HSPs after heat shock through inhibition of HSF activation. Quercetin 0-9 interleukin 6 Homo sapiens 30-33 1321338-9 1992 Quercetin thus interacts with HSF and inhibits the induction of HSPs after heat shock through inhibition of HSF activation. Quercetin 0-9 interleukin 6 Homo sapiens 108-111 31887433-8 2020 The mRNA expression of IL-6, IL-8 and PTGS2 in HT-29 cells decreased by more than 60% upon incubation with CD + SPM138 co-cultures as compared to the levels observed after treatment with CD supernatant only. cd + 107-111 interleukin 6 Homo sapiens 23-27 1367984-0 1992 A CHO strain producing high-level human IL-6 with the 3" deletion construct. cho 2-5 interleukin 6 Homo sapiens 40-44 32013062-6 2020 Colonic pro-inflammatory mediators, including tumor necrosis factor-alpha, interleukin (IL)-1 beta, and IL-6, as well as myeloperoxidase activities were decreased following galangin pre-treatment when compared with the DSS control group. galangin 173-181 interleukin 6 Homo sapiens 104-108 31979305-2 2020 Epigallocatechin gallate (EGCG) decreases IL-6, which could be enhanced by the anti-inflammatory effect of high ketone bodies after administering coconut oil (both of which are an anxiolytic). Ketones 112-118 interleukin 6 Homo sapiens 42-46 31859422-9 2020 The results showed that loganin repressed the expression and release of IL-6, TNF-alpha, and IL-1beta, and inhibited TLR4/NF-kappaB and JAK/STAT3 signaling pathways in a concentration-dependent manner. loganin 24-31 interleukin 6 Homo sapiens 72-76 32296689-2 2020 High molecular weight hyaluronan (hMwt HA) is one of the most abundant bioactive macromolecules of healthy synovial fluid (hSF) and it plays an important role in the protection of opposing articular cartilage surfaces within the synovial joint. Hyaluronic Acid 22-32 interleukin 6 Homo sapiens 123-126 31960968-9 2020 RESULTS: We report here that UDCA significantly reduced the IL1beta and TNFalpha-induced expression of IL1, IL6 and IL8 in gingival fibroblasts and the HSC-2 cell line. Ursodeoxycholic Acid 29-33 interleukin 6 Homo sapiens 108-111 1730219-9 1992 The presence of the oligomannose structures and the mannose-terminating tetrasaccharide on IL-6 may be important in maintaining a high local concentration of the cytokine while limiting its systemic serum level via interaction with soluble mannose-binding serum lectins. oligomannose 20-32 interleukin 6 Homo sapiens 91-95 31960968-10 2020 In RAW 264.7 macrophages, UDCA attenuated the expression of IL1alpha, IL1beta and IL6 that was increased by saliva. Ursodeoxycholic Acid 26-30 interleukin 6 Homo sapiens 82-85 31960968-11 2020 Immunoassay confirmed the capacity of UDCA to reduce inflammation-induced production of IL6 in gingival fibroblasts, HSC-2 and RAW 264.7 cells. Ursodeoxycholic Acid 38-42 interleukin 6 Homo sapiens 88-91 1797449-6 1991 The addition of interleukin-6 to all-trans retinoic acid-treated cultures of HL-60 human myeloid leukaemia cells significantly enhanced the desired antiproliferation effect of all-trans retinoic acid. 2-octenal 37-42 interleukin 6 Homo sapiens 16-29 32273893-11 2020 Real-time PCR demonstrated that 50 microg/ml vitamin C significantly increased fibroblast expression of COL1, FN, IL-6, and bFGF. Ascorbic Acid 45-54 interleukin 6 Homo sapiens 114-118 32273893-13 2020 However, 50 microg/ml of vitamin C increases the expression of COL1, FN, IL-6, and bFGF, which are related to fibroblast wound healing activity. Ascorbic Acid 25-34 interleukin 6 Homo sapiens 73-77 1937963-3 1991 Treatment of ACHN cells with rh IFN-gamma also leads to inhibition of proliferation of these cells in a dose-dependent manner, that can be reversed by exogenous rh IL-6, while IFN-alpha, IL-2, IL-4 and vinblastine or 17-beta-estradiol has no effect on growth (3H-thymidine uptake) of ACHN cells and IL-6 expression. 3h-thymidine 260-272 interleukin 6 Homo sapiens 164-168 32126510-8 2020 CONCLUSION: The results showed that in PBMCs, miR-98-5p can target CCL3 to decrease its expression and thereby increase the IL-6 levels, and the resulting increase in IL-6 can decrease C1GALT1 expression. mir-98-5p 46-55 interleukin 6 Homo sapiens 124-128 31747547-8 2020 Furthermore, salidroside remarkably decreased the levels of the pro-inflammatory cytokines TNF-alpha, IL-1beta and IL-6 and impeded the expression of VCAM-1 and ICAM-1 induced by AGEs. rhodioloside 13-24 interleukin 6 Homo sapiens 115-119 2025958-9 1991 Synergism of coumarin and endotoxin in the induction of interleukin-6 or tumour necrosis factor-alpha could be observed in a smaller percentage of donors. coumarin 13-21 interleukin 6 Homo sapiens 56-101 31924632-12 2020 Interleukin 6, erythrocyte sedation rate and C-reactive protein levels were reduced at 72 hours, 2 weeks and 4 weeks and prostaglandin E2 levels were reduced at 48 hours and 72 hours in the parecoxib/celecoxib group compared with the placebo group. parecoxib 190-199 interleukin 6 Homo sapiens 0-13 31786654-7 2020 Next, treatment with the inhibitor revealed that TAK-242 suppressed the inflammatory condition of ovarian cancer cells, as evident by the down-regulation of IL-6 gene expression. ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate 49-56 interleukin 6 Homo sapiens 157-161 31841757-7 2020 Inhibition of miR-92a ameliorated the inflammatory response by decreasing the release of the proinflammatory factors IL-6 and TNF-alpha. mir-92a 14-21 interleukin 6 Homo sapiens 117-121 30843768-5 2020 Treatment with alpha-tocopherol (10, 100, and 1,000 muM) and ascorbic acid (15, 150, and 1,500 muM) at the same time that the dextrose was added reduced IL-1beta, IL-6, and IL-8 levels in culture media from cells maintained at 5.5 mM dextrose but had no effect on IL-1beta, IL-6, and IL-8 levels in cells exposed to 27.5 mM dextrose. alpha-Tocopherol 15-31 interleukin 6 Homo sapiens 163-167 30843768-5 2020 Treatment with alpha-tocopherol (10, 100, and 1,000 muM) and ascorbic acid (15, 150, and 1,500 muM) at the same time that the dextrose was added reduced IL-1beta, IL-6, and IL-8 levels in culture media from cells maintained at 5.5 mM dextrose but had no effect on IL-1beta, IL-6, and IL-8 levels in cells exposed to 27.5 mM dextrose. alpha-Tocopherol 15-31 interleukin 6 Homo sapiens 274-278 30843768-5 2020 Treatment with alpha-tocopherol (10, 100, and 1,000 muM) and ascorbic acid (15, 150, and 1,500 muM) at the same time that the dextrose was added reduced IL-1beta, IL-6, and IL-8 levels in culture media from cells maintained at 5.5 mM dextrose but had no effect on IL-1beta, IL-6, and IL-8 levels in cells exposed to 27.5 mM dextrose. Ascorbic Acid 61-74 interleukin 6 Homo sapiens 163-167 30843768-5 2020 Treatment with alpha-tocopherol (10, 100, and 1,000 muM) and ascorbic acid (15, 150, and 1,500 muM) at the same time that the dextrose was added reduced IL-1beta, IL-6, and IL-8 levels in culture media from cells maintained at 5.5 mM dextrose but had no effect on IL-1beta, IL-6, and IL-8 levels in cells exposed to 27.5 mM dextrose. Ascorbic Acid 61-74 interleukin 6 Homo sapiens 274-278 31864360-8 2019 RESULTS: CF cells exposed to digitoxin exhibited significant suppression of both TNFalpha/NFkappaB signaling and downstream secretion of IL-8, IL-6 and GM-CSF, with or without co-treatment with VX drugs. Digitoxin 29-38 interleukin 6 Homo sapiens 143-147 31791385-12 2019 Treatment of GBM cells with MC4040 and MC4041 also impaired the GBM pro-inflammatory phenotype, with a significant decrease of TGF-beta, TNF-alpha, and IL-6, joined to an increase of the anti-inflammatory cytokine IL-10. NCX 4040 28-34 interleukin 6 Homo sapiens 152-156 31470141-0 2019 Reversine inhibits MMP-3, IL-6 and IL-8 expression through suppression of ROS and JNK/AP-1 activation in interleukin-1beta-stimulated human gingival fibroblasts. 2-(4-morpholinoanilino)-6-cyclohexylaminopurine 0-9 interleukin 6 Homo sapiens 26-30 31476115-7 2019 Our results show that APZ and the known DHCR7 inhibitor, AY9944, increase 7-DHC levels in airway epithelial cells and potentiate O3-induced IL-6 and IL-8 expression and cytokine release. Aripiprazole 22-25 interleukin 6 Homo sapiens 140-144 31476115-9 2019 Additionally, we find that APZ increases O3-induced IL-6 and IL-8 expression in human nasal epithelial cells from male but not female donors. Aripiprazole 27-30 interleukin 6 Homo sapiens 52-56 30989422-3 2019 Several genetic variants are reported to be associated with obesity and hypo adiponectinemia, including ars1800796 polymorphism of the interleukin-6 (IL-6) gene. ars1800796 104-114 interleukin 6 Homo sapiens 135-148 30989422-3 2019 Several genetic variants are reported to be associated with obesity and hypo adiponectinemia, including ars1800796 polymorphism of the interleukin-6 (IL-6) gene. ars1800796 104-114 interleukin 6 Homo sapiens 150-154 31491033-8 2019 An enzyme-linked immunosorbent assay (ELISA)-based cytokine array identified interleukin (IL)-6 and IL-8, which show pleiotropic regulatory effects on lung cancer cells, to be specifically produced in higher amounts by the three types of asbestos-exposed lung fibroblasts than normal lung fibroblasts. Asbestos 238-246 interleukin 6 Homo sapiens 77-95 31483851-0 2019 Retraction: Novel Single Nucleotide Polymorphisms in Interleukin 6 Affect Tacrolimus Metabolism in Liver Transplant Patients. Tacrolimus 74-84 interleukin 6 Homo sapiens 53-66 31322196-5 2019 The expression levels of interleukin (IL)-6, IL-8 and monocyte chemoattractant protein-1 increased following treatment with S100A8 and S100A9, and the increase was significantly blocked by specific signaling pathway inhibitors, including toll-like receptor 4 inhibitor (TLR4i), rottlerin, PD98059, SB203580 and BAY-11-7085. BAY 11-7085 311-322 interleukin 6 Homo sapiens 25-43 31243136-0 2019 Pentagalloylglucose Inhibits the Replication of Rabies Virus via Mediation of the miR-455/SOCS3/STAT3/IL-6 Pathway. pentagalloylglucose 0-19 interleukin 6 Homo sapiens 102-106 31243136-6 2019 Finally, activated STAT3 elicited the expression of interleukin-6 (IL-6), thereby contributing to RABV-associated encephalomyelitis; however, PGG restored the level of IL-6 in vitro and in vivo in a SOCS3/STAT3-dependent manner. pentagalloylglucose 142-145 interleukin 6 Homo sapiens 168-172 31293216-5 2019 Results: In vitro, astragaloside induced a dose-dependent inhibition of IL-1beta-induced the production of inflammatory factors, including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), nitric oxide (NO), prostaglandin E2 (PGE2), expression of MMP 13 and ADAMTS-5, and the activation of NF-kappaB signaling. astragaloside 19-32 interleukin 6 Homo sapiens 139-152 31293216-5 2019 Results: In vitro, astragaloside induced a dose-dependent inhibition of IL-1beta-induced the production of inflammatory factors, including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), nitric oxide (NO), prostaglandin E2 (PGE2), expression of MMP 13 and ADAMTS-5, and the activation of NF-kappaB signaling. astragaloside 19-32 interleukin 6 Homo sapiens 154-158 30919561-0 2019 Epimagnolin A inhibits IL-6 production by inhibiting p38/NF-kappaB and AP-1 signaling pathways in PMA-stimulated THP-1 cells. Epimagnolin A 0-13 interleukin 6 Homo sapiens 23-27 30919561-4 2019 In this study, it was demonstrated that epimagnolin A reduced phorbol-12-myristate-13-acetate (PMA)-induced IL-6 promoter activity and IL-6 production in human monocytic THP-1 cells. Epimagnolin A 40-53 interleukin 6 Homo sapiens 108-112 30919561-4 2019 In this study, it was demonstrated that epimagnolin A reduced phorbol-12-myristate-13-acetate (PMA)-induced IL-6 promoter activity and IL-6 production in human monocytic THP-1 cells. Epimagnolin A 40-53 interleukin 6 Homo sapiens 135-139 30919561-7 2019 The results revealed that epimagnolin A attenuated the binding affinity of NF-kappaB and AP-1 transcription factors to IL-6 promoter and IL-6 production through p38/NF-kB and AP-1 signaling pathways in the PMA-stimulated THP-1 cells. Epimagnolin A 26-39 interleukin 6 Homo sapiens 119-123 30919561-7 2019 The results revealed that epimagnolin A attenuated the binding affinity of NF-kappaB and AP-1 transcription factors to IL-6 promoter and IL-6 production through p38/NF-kB and AP-1 signaling pathways in the PMA-stimulated THP-1 cells. Epimagnolin A 26-39 interleukin 6 Homo sapiens 137-141 31059084-0 2019 Eicosapentaenoic acid suppresses angiogenesis via reducing secretion of IL-6 and VEGF from colon cancer-associated fibroblasts. Eicosapentaenoic Acid 0-21 interleukin 6 Homo sapiens 72-76 31059084-9 2019 While LPS stimulation increased VEGF secretion from the two fibroblast types, EPA decreased IL-6 and VEGF secretion from CAFs. Eicosapentaenoic Acid 78-81 interleukin 6 Homo sapiens 92-96 30796902-12 2019 Molecular docking results indicates interaction of cinnamaldehyde and eugenol with key residues of TNF-alpha and IL-6. Eugenol 70-77 interleukin 6 Homo sapiens 113-117 30794283-0 2019 Cooperative effects of sequential PGF2alpha and IL-1beta on IL-6 and COX-2 expression in human myometrial cells . Dinoprost 34-43 interleukin 6 Homo sapiens 60-64 30794283-5 2019 Sequential stimulation of HMSMC by PGF2alpha and IL-1beta in either order results in amplified upregulation of IL-6 and COX-2 mRNA and protein, compared to their effects individually. Dinoprost 35-44 interleukin 6 Homo sapiens 111-115 30794283-7 2019 These results suggest that PGF2alpha and IL-1beta act cooperatively upstream in the birth cascade to maximize amplification of IL-6 and COX-2, to build inflammatory load and thereby promote uterine transition. Dinoprost 27-36 interleukin 6 Homo sapiens 127-131 30794283-8 2019 Targeting PGF2alpha or IL-1beta, their actions, or intermediates (e.g. IL-6) would be an effective therapeutic intervention for preterm birth prevention or delay. Dinoprost 10-19 interleukin 6 Homo sapiens 71-75 31105837-7 2019 However, vitamin C stimulated lower Cbfa1, Col-1, ALP, OPN, BSP, OCN, VDR, CEMP-1 and IL-6 mRNA fold-changes than 10-8 M calcitriol. Ascorbic Acid 9-18 interleukin 6 Homo sapiens 86-90 31013891-8 2019 Overall, our results suggest that certain immune markers, such as IL-6 and the frequency of effector T cells, could be predictive of therapeutic response to ADT therapies in mCRPC patients. adt 157-160 interleukin 6 Homo sapiens 66-70 32148007-8 2020 We used the the cell line screened out dendrobiine and tetrandrine which could significantly inhibit IL-6/STAT3 signal pathway and down-regulated the expression of Bcl-2 and Bcl-x in a dose-dependent manner. dendrobiine 39-50 interleukin 6 Homo sapiens 101-105 32148007-8 2020 We used the the cell line screened out dendrobiine and tetrandrine which could significantly inhibit IL-6/STAT3 signal pathway and down-regulated the expression of Bcl-2 and Bcl-x in a dose-dependent manner. tetrandrine 55-66 interleukin 6 Homo sapiens 101-105 32098277-7 2020 Kaempferol stimulated nuclear factor kappa B (NF-kappaB) signaling in lipopolysaccharide (LPS)-treated THP-1 cells, thereby increasing the mRNA expression of interleukin (IL) 1 beta, tumor necrosis factor, and nuclear factor kappa B subunit 1, while IL6 was downregulated. kaempferol 0-10 interleukin 6 Homo sapiens 250-253 32024920-0 2020 Author Correction: Novel Indole-fused benzo-oxazepines (IFBOs) inhibit invasion of hepatocellular carcinoma by targeting IL-6 mediated JAK2/STAT3 oncogenic signals. Oxazepines 38-54 interleukin 6 Homo sapiens 121-125 31836387-5 2020 Eukaryotic transcriptome sequencing and western blot analysis demonstrated that 1,3-DCQA binds to 14-3-3tau to prevent breast cancer proliferation and metastasis via Jak/PI3K/Akt and Raf/ERK pathway, which promote IL6 and CSF3 expression raised by CREB (CREBBP, CREB5) and induced cell apoptosis via Bad/Bax/caspase 9 signaling pathway. interferon tau 98-107 interleukin 6 Homo sapiens 214-217 31955966-3 2020 This study systematically reviewed and summarized earlier findings from randomized clinical trials about the effects of statins on serum concentrations of C-reactive protein (CRP) and interleukin (IL)-6 in patients with abnormal glucose homeostasis. Simvastatin 120-127 interleukin 6 Homo sapiens 184-202 31955966-5 2020 RCTs were included if they compared the effects of statins on serum concentrations of CRP and IL-6 in adults with abnormal glucose homeostasis. Simvastatin 51-58 interleukin 6 Homo sapiens 94-98 32245324-9 2020 Pre-treatment with curcumin, DPI and NAC inhibited TGF-beta-induced IL-6 (p=0.04) and TNF-alpha (p=0.001) mRNA expression, Smad2L phosphorylation (p=0.02) and ROS production (0.03). 3-aminodiphenyleneiodium 29-32 interleukin 6 Homo sapiens 68-72 31630264-10 2020 Additionally, the cross-linked hyaluronic acid gel could inhibit IL-6 secretion. Hyaluronic Acid 31-46 interleukin 6 Homo sapiens 65-69 31630264-11 2020 CONCLUSIONS: These results indicate that cross-linked hyaluronic acid gel can prevent epidural adhesion by inhibiting inflammatory factors, such as IL-6, and downregulating TGFbeta1 and COL1A1 mRNA expression. Hyaluronic Acid 54-69 interleukin 6 Homo sapiens 148-152 32844633-7 2020 Blockade of 5-HT2B-receptors with specific antagonist RS 127445 reduced the inhibitory effect of fluoxetine on IL-1beta production in both groups and IL-6 production in healthy subjects. 2-amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine 54-63 interleukin 6 Homo sapiens 150-154 31920355-12 2019 Further investigation indicated that Salidroside down-regulated the mRNA expression of IL-1beta and IL-6-pro-inflammatory cytokines. rhodioloside 37-48 interleukin 6 Homo sapiens 100-104 31885670-11 2019 In addition, molecular docking simulation indicated that CSF2, IL1beta, TNF, and IL6 had good binding activity with the corresponding compounds (degree > 10).The 6 compounds (degree >= 5) of HS and essential oil had good interaction with 5 or more targets. hassio 191-193 interleukin 6 Homo sapiens 81-84 31885670-11 2019 In addition, molecular docking simulation indicated that CSF2, IL1beta, TNF, and IL6 had good binding activity with the corresponding compounds (degree > 10).The 6 compounds (degree >= 5) of HS and essential oil had good interaction with 5 or more targets. Oils, Volatile 198-211 interleukin 6 Homo sapiens 81-84 31257245-4 2019 The plasma IL-6 levels in the children with RMPP were higher than those in the children with GMPP (P<0.05), but the IL-17 levels showed the opposite trend (P<0.05). rmpp 44-48 interleukin 6 Homo sapiens 11-15 30953364-7 2019 Effect of SDF-1alpha-induced upregulation of IL-6 on chemotherapeutic resistance and apoptosis of RPMI-8226 cells in adhesion state was analyzed. [(R)-(2,4-dichlorophenyl)(sulfanyl)methyl]phosphonic acid 10-13 interleukin 6 Homo sapiens 45-49 31490211-10 2019 Cannabis-plus-cocaine use increased CRP, IL-8 and IL-6/IL-10 ratio, but decreased thiol content, and inflammatory and activated-classic monocyte percentages. Cocaine 14-21 interleukin 6 Homo sapiens 50-54 31572532-11 2019 ASI also decreased the levels of the pro-inflammatory factors MPO, TNF-alpha, IL-1beta, IL-6 and NO, and upregulated the expression of claudin-1 and ZO-1 in colon tissues. astragaloside A 0-3 interleukin 6 Homo sapiens 88-92 31547604-6 2019 Transcriptional analyses showed that exogenous GABA could significantly upregulate transcript levels of genes encoding heat shock factor HSFs (HSFA-6a, HSFA-2c, and HSFB-2b), heat shock proteins (HSP17.8, HSP26.7, HSP70, and HSP90.1-b1), and ascorbate peroxidase 3 (APX3), whereas the inhibition of GABA biosynthesis depressed these genes expression under heat stress. Ascorbic Acid 242-251 interleukin 6 Homo sapiens 119-136 31059760-7 2019 Compared to the treatment with LPS only, LPS/APAP co-exposures induced the production of interleukin (IL)-8, a pro-inflammatory cytokine, but suppressed the secretion of IL-6, a cytokine regulating hepatic regeneration, along with the increase in APAP dosages. Acetaminophen 45-49 interleukin 6 Homo sapiens 170-174 31455761-10 2019 Plasma EPA level was negatively correlated with IL-6 and TNFalpha levels. Eicosapentaenoic Acid 7-10 interleukin 6 Homo sapiens 48-52 31364422-3 2021 Results: Captopril significantly (p < .05) inhibited TAA-induced hypertension, liver tissue levels of mTOR, TIMP-1, TNF-alpha, IL-6, MDA; and blood levels of lipids, ALT, and AST. Captopril 9-18 interleukin 6 Homo sapiens 130-134 30355438-3 2019 Pretreatment of these cells with KHG26702 significantly attenuated OGD-R-induced production of reactive oxygen species and elevation of levels of malondialdehyde, prostaglandin E2, interleukin 6 and glutathione, as well as superoxide dismutase activity. khg26702 33-41 interleukin 6 Homo sapiens 181-194 31005040-8 2019 Further studies showed that PPARgamma inhibitor GW9662 could reverse the inhibition of oridonin on PGE2, NO, IL-6, and IL-8 production. 2-chloro-5-nitrobenzanilide 48-54 interleukin 6 Homo sapiens 109-113 31004811-5 2019 The resulting PGZ-NE showed good anti-inflammatory efficacy by decreasing the expression of inflammatory cytokines IL-6, IL-1beta and TNF-alpha. pgz-ne 14-20 interleukin 6 Homo sapiens 115-119 30630742-8 2019 RESULTS: The post-exercise IL-6 increase was greater in LCHF (p<0.001) during both the Adapt (LCHF: 13.1-fold increase; 95% CI: 5.6-23.0, CHO: 8.0-fold increase; 5.1-11.1) and CHO Restoration trials (LCHF: 18.5-fold increase; 10.9-28.9, CHO: 6.3-fold increase; 3.9-9.5); outcomes were not different between trials (p=0.84). CAV protocol 141-144 interleukin 6 Homo sapiens 27-31 30630742-8 2019 RESULTS: The post-exercise IL-6 increase was greater in LCHF (p<0.001) during both the Adapt (LCHF: 13.1-fold increase; 95% CI: 5.6-23.0, CHO: 8.0-fold increase; 5.1-11.1) and CHO Restoration trials (LCHF: 18.5-fold increase; 10.9-28.9, CHO: 6.3-fold increase; 3.9-9.5); outcomes were not different between trials (p=0.84). CAV protocol 179-182 interleukin 6 Homo sapiens 27-31 30630742-8 2019 RESULTS: The post-exercise IL-6 increase was greater in LCHF (p<0.001) during both the Adapt (LCHF: 13.1-fold increase; 95% CI: 5.6-23.0, CHO: 8.0-fold increase; 5.1-11.1) and CHO Restoration trials (LCHF: 18.5-fold increase; 10.9-28.9, CHO: 6.3-fold increase; 3.9-9.5); outcomes were not different between trials (p=0.84). CAV protocol 179-182 interleukin 6 Homo sapiens 27-31 31139184-3 2019 Pretreatment of human RASFs with JWH-015 (10-20 muM) markedly inhibited the ability of pro-inflammatory cytokine interleukin-1beta (IL-1beta) to induce production of IL-6 and IL-8 and cellular expression of inflammatory cyclooxygenase-2 (COX-2). JHW 015 33-40 interleukin 6 Homo sapiens 166-170 29232287-7 2019 Similar effects on IL-1beta, IL-6, and IL-8 levels were observed when cells were treated with simvastatin, pravastatin, and the renin-angiotensin system inhibitors spironolactone, captopril, lisinopril, candesartan, and losartan. Simvastatin 94-105 interleukin 6 Homo sapiens 29-33 30900815-4 2019 The in vitro study indicates that supplementation of high-dose DHA+EPA induces the greatest decrease of IL-6 production by PBMCs relative to other groups (p = 0.046). Eicosapentaenoic Acid 67-70 interleukin 6 Homo sapiens 104-108 31110596-6 2019 Results: Urinary KIM-1, IL-1, IL-6, and TNF-alpha were higher in patients with serum uric acid concentrations >= 6.0 mg/dL. Uric Acid 85-94 interleukin 6 Homo sapiens 30-34 30963625-9 2019 Lidocaine dramatically reduced the protein expression of IL-1alpha, IL-6, THF-alpha, ELAVL1, NLRP3, caspase-1, and IL-1beta in adenovirus-infected thyroid follicular epithelial cells. Lidocaine 0-9 interleukin 6 Homo sapiens 68-72 30906479-10 2019 Thus, these findings indicate that IL-27 and IL-6 may be trait markers in patients being administered olanzapine monotherapy at the onset of schizophrenia. Olanzapine 102-112 interleukin 6 Homo sapiens 45-49 30404019-7 2019 Collagen type I production in SSc fibroblasts by ATP-induced IL-6/IL-6 receptor trans-signaling was inhibited by kaempferol and SB203580. kaempferol 113-123 interleukin 6 Homo sapiens 61-65 30404019-5 2019 Nonselective P2 receptor antagonist and selective P2Y2 receptor antagonists, kaempferol and AR-C118925XX, significantly inhibited ATP-induced IL-6 production and phosphorylation of p38 in SSc fibroblasts. kaempferol 77-87 interleukin 6 Homo sapiens 142-146 1995637-3 1991 Transfected cells exhibited a single class of binding sites for 125I-labeled recombinant human interleukin-6 (125I-rhIL-6) (Kd = 440 pM, 20,000 receptors per cell). Iodine-125 64-68 interleukin 6 Homo sapiens 95-108 30988608-9 2019 In vivo IONP-PEG induced an increment in complement activation markers (C5a and C5b-9), and proinflammatory cytokines (IL-1beta, IL-6, TNF-alpha). ionp-peg 8-16 interleukin 6 Homo sapiens 129-133 30371044-7 2019 Besides, the expression levels of low-density lipoprotein receptor-1 (LOX-1) and nuclear factor-kappaB (NF-kappaB) were significantly decreased, and the expression levels of downstream factors interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) were also obviously decreased in the cells treated with albiflorin but not in the negative control cells. albiflorin 314-324 interleukin 6 Homo sapiens 208-212 1715769-1 1990 The cDNA for human interleukin 6 (IL 6) was stably expressed at high levels in the three mammalian cell lines COS-7, PA317, and GH3 to yield IL 6 proteins of 25 to 27, 26, 22 to 24, and 23 kDa molecular mass. cos-7 110-115 interleukin 6 Homo sapiens 19-32 30984167-14 2019 In contrast, only peficitinib and filgotinib decreased the IL-6 release of RASF activated with IL-1beta. peficitinib 18-29 interleukin 6 Homo sapiens 59-63 30887238-1 2019 A physiologically based pharmacokinetic (PBPK) model was used to simulate the impact of elevated levels of interleukin (IL)-6 on the exposure of several orally administered cytochrome P450 (CYP) probe substrates (caffeine, S-warfarin, omeprazole, dextromethorphan, midazolam, and simvastatin). Simvastatin 280-291 interleukin 6 Homo sapiens 107-125 30866458-9 2019 In particular, menadione inhibited nuclear factor kappa-light-chain-enhancer of activated B cell (NF-kappaB) activation and thereby reduced expression of the proinflammatory cytokines such as IL-1beta, IL-6, IL-8, and TNF-alpha in AGS as well as in THP-1 (monocytic leukemia cell) cell lines. Vitamin K 3 15-24 interleukin 6 Homo sapiens 202-206 1715769-1 1990 The cDNA for human interleukin 6 (IL 6) was stably expressed at high levels in the three mammalian cell lines COS-7, PA317, and GH3 to yield IL 6 proteins of 25 to 27, 26, 22 to 24, and 23 kDa molecular mass. cos-7 110-115 interleukin 6 Homo sapiens 34-38 30363006-1 2019 PURPOSE: The short-term restriction of carbohydrate (CHO) can potentially influence iron regulation via modification of postexercise interleukin-6 (IL-6) and hepcidin levels. CAV protocol 53-56 interleukin 6 Homo sapiens 133-146 30866565-6 2019 Omega-6 fatty acids were consistently positively associated with pro-inflammatory IL-6 and IL-8 at baseline. Fatty Acids, Omega-6 0-19 interleukin 6 Homo sapiens 82-86 2236903-3 1990 NADPH level and NADPH/NADP+ ratio underwent a slight decrease in normal HSF incubated with 2.5 microM BaP, while a greater fall occurred in the deficient HSF at 0.25 and 2.5 microM BaP. NADP 0-5 interleukin 6 Homo sapiens 72-75 30461427-0 2019 Proinflammatory and anti-inflammatory biomarkers in schizophrenia and influence of simvastatin on the interleukin-6. Simvastatin 83-94 interleukin 6 Homo sapiens 102-115 30461427-4 2019 Interestingly, patients on simvastatin had lower interleukin-6 levels compared with patients not on simvastatin and controls. Simvastatin 27-38 interleukin 6 Homo sapiens 49-62 30363006-1 2019 PURPOSE: The short-term restriction of carbohydrate (CHO) can potentially influence iron regulation via modification of postexercise interleukin-6 (IL-6) and hepcidin levels. CAV protocol 53-56 interleukin 6 Homo sapiens 148-152 30363006-9 2019 CONCLUSION: Athletes who adhered to a CHO-rich diet experienced favorable changes to the postexercise IL-6 and hepcidin response, relative to the LCHF group. CAV protocol 38-41 interleukin 6 Homo sapiens 102-106 2165096-5 1990 In contrast, the addition of 1-(5-isoquinolinesulfonyl)-2-methylpiperizine dihydrochloride (H7), an inhibitor of protein kinase C activity, markedly inhibited IL-6-stimulated IgM production by SKW6.4 cells. 1-(5-isoquinolinesulfonyl)-2-methylpiperizine dihydrochloride 29-90 interleukin 6 Homo sapiens 159-163 30728070-9 2019 The HDAC6-selective inhibitors ACY-1215 (ricolinostat) and ACY-241 (citarinostat) decreased Th2 cytokine production (i.e. IL-4, IL-5, IL-6, IL-10 and IL-13). Citarinostat 59-66 interleukin 6 Homo sapiens 134-138 2119190-3 1990 Among the agents affecting the signal transduction pathways, forskolin significantly induced PSTI secretion whereas PMA or A23187 did not, suggesting that IL-6 induced PSTI secretion is mediated by cAMP dependent protein kinase A. Colforsin 61-70 interleukin 6 Homo sapiens 155-159 30578968-8 2019 Furthermore, the anti-inflammatory effects of TXA were associated with the inhibition of TLR2, pro-inflammatory cytokines (IL-6 and TNFalpha) and chemokines (CCL10) expression in LL37-activated HaCaT cells. Tranexamic Acid 46-49 interleukin 6 Homo sapiens 123-140 30997266-10 2019 The interleukin-6 level increased by 2.5 fold (p < 0.01) with TNF-alpha, but decreased by 24%, 32%, and 28% (p < 0.01), respectively, with AVA-A, -B, and -C. The interleukin-1beta level also showed a 47% increase with TNF-alpha (p < 0.01), whereas this increment was abolished in all AVA-treated cells. avenanthramide-2C 145-148 interleukin 6 Homo sapiens 4-17 2386010-7 1990 The culture supernatant of these hairy cells increased 3H-thymidine uptake of a IL-6 dependent hybridoma clone (MH60) in a dose-dependent manner. 3h-thymidine 55-67 interleukin 6 Homo sapiens 80-84 30733507-4 2019 Long-term treatment of olanzapine caused metabolic symptoms, including IR, by markedly elevating the plasma levels of pro-inflammatory cytokines, including IL-1ss, IL-6, IL-8 and TNFalpha; these findings are consistent with observations from schizophrenia patients chronically treated with olanzapine. Olanzapine 23-33 interleukin 6 Homo sapiens 164-168 30728070-9 2019 The HDAC6-selective inhibitors ACY-1215 (ricolinostat) and ACY-241 (citarinostat) decreased Th2 cytokine production (i.e. IL-4, IL-5, IL-6, IL-10 and IL-13). Citarinostat 68-80 interleukin 6 Homo sapiens 134-138 30428424-8 2019 RESULTS: Incubation with EPA and/or DHA attenuated inflammatory response to lipopolysaccharide (LPS) and monocyte co-culture with reduction in post-LPS mRNA expression and protein levels of IL6, CCL2 and CX3CL1. Eicosapentaenoic Acid 25-28 interleukin 6 Homo sapiens 190-193 33779948-5 2021 RESULTS: PF significantly inhibited the proliferation while promotes the apoptosis of THP-1 cells, and inhibited the release of IL-6, TNF-alpha and IL-1betain THP-1 cells. peoniflorin 9-11 interleukin 6 Homo sapiens 128-132 30827352-11 2019 PGF2alpha increased mRNA content and protein activity of MMP9, and gene and protein expression of interleukin-6 (P < 0.05). Dinoprost 0-9 interleukin 6 Homo sapiens 98-111 30811143-5 2019 More importantly, when compared with another direct AR antagonist, enzalutamide, clascoterone was significantly better at inhibiting IL-6 synthesis from DHT-stimulated primary cultures of human scalp DPC. Clascoterone 81-93 interleukin 6 Homo sapiens 133-137 33236146-10 2021 The IL-1beta-induced increase in the expression of IL-6 was decreased by treatment with scutellarin; however, scutellarin did not alter the expression of C-reactive protein and tumor necrosis factor-alpha. scutellarin 88-99 interleukin 6 Homo sapiens 51-55 30697360-11 2019 Furthermore, 10 nM of 1alpha,25(OH)2D3 generally inhibited the IL-6 and IL-1beta-mediated inflammatory responses, and reduced both p44/42 MAPK and relA phosphorylation in MacCM-stimulated preadipocytes. 25(oh)2d3 29-38 interleukin 6 Homo sapiens 63-67 31038541-6 2019 It was found that pre-treat with candesartan significantly suppressed transforming growth factor-beta (TGF-beta) and interleukin-6 (IL-6) expression after incubation with TNF-alpha. candesartan 33-44 interleukin 6 Homo sapiens 117-130 31038541-6 2019 It was found that pre-treat with candesartan significantly suppressed transforming growth factor-beta (TGF-beta) and interleukin-6 (IL-6) expression after incubation with TNF-alpha. candesartan 33-44 interleukin 6 Homo sapiens 132-136 33379200-8 2020 Both iron oxide and silica enhanced LPS-induced production of TNF-alpha, IL-1beta, IL-6 and IL-8 in THP-1 cells with most of these responses replicated in PBMCs. ferric oxide 5-15 interleukin 6 Homo sapiens 83-87 11770011-8 2001 Moreover, theophylline inhibited interleukin-6 production induced by TNF-alpha in A549 cells. Theophylline 10-22 interleukin 6 Homo sapiens 33-46 30399404-12 2019 IL-6 response to stress was buffered among high ACE women with high intake of docosahexaenoic acid (DHA) (p = 0.03) and eicosapentaenoic acid (EPA) (p = 0.05). Eicosapentaenoic Acid 120-141 interleukin 6 Homo sapiens 0-4 30399404-12 2019 IL-6 response to stress was buffered among high ACE women with high intake of docosahexaenoic acid (DHA) (p = 0.03) and eicosapentaenoic acid (EPA) (p = 0.05). Eicosapentaenoic Acid 143-146 interleukin 6 Homo sapiens 0-4 30407866-7 2019 In ASM cells, challenge with acetate also enhanced TNFalpha-induced IL-6, but not CXCL8 release. Acetates 29-36 interleukin 6 Homo sapiens 68-72 34687791-0 2022 Induction of IL-6Ralpha by ATF3 enhances IL-6 mediated sorafenib and regorafenib resistance in hepatocellular carcinoma. Sorafenib 55-64 interleukin 6 Homo sapiens 41-45 31582650-4 2019 2FL reduced PM10-induced excess expression of interleukin (IL)-6, IL-8, IL-1alpha and IL-1beta in HaCaT keratinocytes. 2'-fucosyllactose 0-3 interleukin 6 Homo sapiens 46-64 31965930-7 2019 The cytotoxicity of four 6- ferrocenylpyrimidin-4(3H)-one derivatives was evaluated by using the MTT assay in vitro against Human breast adenocarcinoma MCF-7 and normal human skin fibroblast HSF cells. 6- ferrocenylpyrimidin-4(3h)- 25-54 interleukin 6 Homo sapiens 191-194 29993265-9 2019 Given that limited trials have focused on EPA or DHA intervention on concentrations of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha, further RCTs should be explored on these inflammatory factors. Eicosapentaenoic Acid 42-45 interleukin 6 Homo sapiens 87-105 30095142-5 2019 The 26 selected articles point towards an association between higher levels of uric acid, homocysteine, and interleukin 6 with lower cognitive performance in executive, attentional, and memory domains. Uric Acid 79-88 interleukin 6 Homo sapiens 108-121 34687791-6 2022 Depletion of IL-6Ralpha abolished IL-6 induced STAT3 phosphorylation at 705th tyrosine and tumor growth of HCC cells under sorafenib treatment. Sorafenib 123-132 interleukin 6 Homo sapiens 34-38 30844798-11 2019 CDCA-induced IL-6 and IL-8 mRNA levels were blocked by guggulsterone. Chenodeoxycholic Acid 0-4 interleukin 6 Homo sapiens 13-17 34687791-8 2022 Depletion of ATF3 or its upstream transcription factor, ATF4, attenuated IL-6Ralpha induction and IL-6 mediated sorafenib resistance. Sorafenib 112-121 interleukin 6 Homo sapiens 98-102 30844798-12 2019 CDCA increased IL-6, tumor necrosis factor-alpha (TNF-alpha), and vascular endothelial growth factor release, whereas guggulsterone significantly blocked IL-6 and TNF-alpha release. Chenodeoxycholic Acid 0-4 interleukin 6 Homo sapiens 15-19 34883342-0 2022 Fluvastatin enhances IL-33-mediated mast cell IL-6 and TNF production. Fluvastatin 0-11 interleukin 6 Homo sapiens 46-50 30944705-0 2019 Salidroside regulates the expressions of IL-6 and defensins in LPS-activated intestinal epithelial cells through NF-kappaB/MAPK and STAT3 pathways. rhodioloside 0-11 interleukin 6 Homo sapiens 41-45 30944705-6 2019 Results: Salidroside impaired the proliferation of intestinal epithelial cells at high concentrations (P< 0.05) and down-regulated interleukin-6 (IL-6) production induced by LPS (P<0.05). rhodioloside 9-20 interleukin 6 Homo sapiens 134-147 30944705-6 2019 Results: Salidroside impaired the proliferation of intestinal epithelial cells at high concentrations (P< 0.05) and down-regulated interleukin-6 (IL-6) production induced by LPS (P<0.05). rhodioloside 9-20 interleukin 6 Homo sapiens 149-153 30944705-9 2019 Conclusion: In summary, salidroside suppressed the expression of IL-6 and elevated the expression of defensins in LPS-activated intestinal epithelial cells through NF-kappaB/MAPK and STAT3 pathways. rhodioloside 24-35 interleukin 6 Homo sapiens 65-69 30420132-13 2018 Exposure to ascorbate- or glutathione-related OP was significantly associated with increased inflammatory and neural biomarkers including interleukin-6, VEGF, UCHL1, and S100 calcium-binding protein B in blood, and malondialdehyde and 8-hydroxy-deoxy-guanosine in urine. Ascorbic Acid 12-21 interleukin 6 Homo sapiens 138-151 30088170-9 2018 In vitro experiments showed that the levels of TNF-alpha, IL-1beta, and IL-6 secreted by human pulmonary microvascular endothelial cells treated with PQ were attenuated by fasudil. Paraquat 150-152 interleukin 6 Homo sapiens 72-76 30428756-7 2018 Furthermore, co-incubation with Tet significantly down-regulated HaCaT cell production of tumour necrosis factor (TNF)-alpha, IL-1beta, IL-6, IL-20 and chemokine (C-C motif) ligand 20 (CCL20) induced by IL-22. tet 32-35 interleukin 6 Homo sapiens 136-140 30144574-6 2018 Our results suggest an immunostimulatory role for the iodine substituted ZnPc on macrophages based on the changes in pro-inflammatory cytokine production levels (TNFalpha, IL1beta and IL6). Iodine 54-60 interleukin 6 Homo sapiens 184-187 30051214-9 2018 The serum IL-6 and CRP levels were inversely correlated with the plasma concentration ratios of N-desmethyltramadol to tramadol and of N,O-didesmethyltramadol to O-desmethyltramadol. N-demethyltramadol 96-115 interleukin 6 Homo sapiens 10-14 30301277-5 2018 Among them, 2-[1-(3-chlorobenzyl)-2,6-dioxopiperidin-3-yl]isoindoline-1,3-dione (5c) was found to inhibit TNF-alpha and IL-6 expression in HaCaT cells with a higher potency than thalidomide and no significant cell cytotoxicity was detected at 10 muM. 2-[1-(3-chlorobenzyl)-2,6-dioxopiperidin-3-yl]isoindoline-1,3-dione 12-79 interleukin 6 Homo sapiens 120-124 29691294-6 2018 Furthermore, the combined targeting of CSCs and their interaction with TAMs by inhibiting ATG7/OCT4 and IL6 receptor effectively ameliorated ADT resistance in an orthotopic prostate cancer model.Conclusions: Targeting CSCs and their niche may prove to be a more powerful strategy than targeting CSCs alone, providing a rational approach to ameliorating ADT resistance in prostate cancer. adt 141-144 interleukin 6 Homo sapiens 104-107 30335249-1 2018 Quinolinic acid activates NMDA receptors in the central nervous system and stimulates the secretion of interleukins IL-6 and 1L-1beta, among others, promoting hyper-activity of the HPA axis and reinforcing a bias of the tryptophan metabolism to produce quinolinic acid, and interleukins by the innate immune system, further reducing the synthesis of serotonin and consolidating the depressive process.We discuss the evidence showing that this process can be initiated by either interleukin stimulated by an infection or some vaccines or excessive psychological stress that activates the HPA axis together with said innate immune response, causing a process of aseptic inflammation in the central nervous system. Quinolinic Acid 0-15 interleukin 6 Homo sapiens 116-133 30335249-1 2018 Quinolinic acid activates NMDA receptors in the central nervous system and stimulates the secretion of interleukins IL-6 and 1L-1beta, among others, promoting hyper-activity of the HPA axis and reinforcing a bias of the tryptophan metabolism to produce quinolinic acid, and interleukins by the innate immune system, further reducing the synthesis of serotonin and consolidating the depressive process.We discuss the evidence showing that this process can be initiated by either interleukin stimulated by an infection or some vaccines or excessive psychological stress that activates the HPA axis together with said innate immune response, causing a process of aseptic inflammation in the central nervous system. Quinolinic Acid 253-268 interleukin 6 Homo sapiens 116-133 28916287-19 2018 The greatest benefit regarding cell survival and reduction of the inflammation-marker IL-6 after a SM treatment was observed after diclofenac treatment. Diclofenac 131-141 interleukin 6 Homo sapiens 86-90 30238726-11 2018 Univariate analysis showed that the level of IL-6 in serum at 1 day after operation was significantly higher in variables as follows: age, diagnosis, history of lung infection, range of motion, preoperative levels of CRP and IL-6 in serum, intravenous dosage of tranexamic acid and dexamethasone on day of operation ( P<0.05). Tranexamic Acid 262-277 interleukin 6 Homo sapiens 45-49 29771572-10 2018 PYR-41 treatment decreased the expression of proinflammatory cytokines IL-6 and IL-1beta as well as chemokines keratinocyte chemoattractant and macrophage inflammatory protein-2 in the gut and lung, which leads to inhibition of neutrophils infiltrating into these organs. 4(4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester 0-6 interleukin 6 Homo sapiens 71-75 30108645-8 2018 ETAS 50 as well as Akt inhibitor Perifosine repressed UV-B irradiation-induced IL-6 mRNA expression. perifosine 33-43 interleukin 6 Homo sapiens 79-83 29896267-0 2018 Lung injury caused by paraquat poisoning results in increased interleukin-6 and decreased microRNA-146a levels. Paraquat 22-30 interleukin 6 Homo sapiens 62-75 29896267-11 2018 Therefore, the present study demonstrated that increased expression of IL-6 in patients with lung injury caused by paraquat poisoning is associated with decreased expression of miR-146a. Paraquat 115-123 interleukin 6 Homo sapiens 71-75 29554535-11 2018 CRP and IL-6 levels were positively correlated in the CBX group, and CRP levels were positively correlated with BMI. cbx 54-57 interleukin 6 Homo sapiens 8-12 29508465-5 2018 The results showed that lipopolysaccharide induced the mRNA and protein levels of IL-6, IL-8, MUC5AC, collagen type I, and fibronectin in 16-HBE cells, whereas casticin treatment significantly inhibited the induction of lipopolysaccharide. casticin 160-168 interleukin 6 Homo sapiens 82-86 29949172-7 2018 CONCLUSIONS: The prolonged sevoflurane inhalational anesthesia time (>= 3 h) enhanced the occurrence of POCD and was related to the expression levels of serum caspase-3, TNF-alpha, and IL-6. pocd 107-111 interleukin 6 Homo sapiens 188-192 30273982-9 2019 Inhibition of TLR-4 signaling, with TAK-242, completely abrogated HMGB1 induced IL-6 and MMP-1 expression, whereas inhibition of TLR-2, with O-vanillin, or RAGE, with FPS-ZM1, had mild inhibitory effects. ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate 36-43 interleukin 6 Homo sapiens 80-84 30608392-8 2019 The meta-analysis demonstrated parecoxib could significantly decrease the incidence of POCD on postoperative day 1, day 3, day 5, and day 7 when compared with control treatment; IL-6 and S100beta concentrations were lower up to postoperative day 2. parecoxib 31-40 interleukin 6 Homo sapiens 178-182 30608392-10 2019 CONCLUSION: Our meta-analysis suggested that the administration of Parecoxib was effective in treating early POCD within 7 days and reducing IL-6 and S100beta concentrations within 2 days after operations. parecoxib 67-76 interleukin 6 Homo sapiens 141-145 30544373-6 2018 As the UA levels increased, MDA increased significantly and SOD decreased significantly; likewise, IL-6 and TNF-alpha increased significantly as the UA level increased. Uric Acid 149-151 interleukin 6 Homo sapiens 99-103 30544373-8 2018 Multivariable logistic regression analysis showed that UA (OR: 2.379, 95% CI: 1.698-3.286, P < .001; OR: 3.261, 95% CI: 1.729-3.857, P < .001; for IL-6 and TNF-alpha, respectively) and MDA (OR: 1.836, 95% CI: 1.283-2.517, P < .01; OR: 2.532, 95% CI: 1.693-3.102, P < .001; for IL-6 and TNF-alpha, respectively) were risk factors for high IL-6 and TNF-alpha and that SOD (OR: 0.517, 95% CI: 0.428-0.763, P < .01; OR: 0.603, 95% CI: 0.415-0.699, P < .001; for IL-6 and TNF-alpha, respectively) was a protective factor.In our study, some abnormal pathological effects were found in asymptomatic young patients with hyperuricemia, suggesting that in young hyperuricemia patients, oxidative stress, inflammation and the inflammatory response may be related to the oxidative stress induced by UA. Uric Acid 55-57 interleukin 6 Homo sapiens 153-157 30544373-8 2018 Multivariable logistic regression analysis showed that UA (OR: 2.379, 95% CI: 1.698-3.286, P < .001; OR: 3.261, 95% CI: 1.729-3.857, P < .001; for IL-6 and TNF-alpha, respectively) and MDA (OR: 1.836, 95% CI: 1.283-2.517, P < .01; OR: 2.532, 95% CI: 1.693-3.102, P < .001; for IL-6 and TNF-alpha, respectively) were risk factors for high IL-6 and TNF-alpha and that SOD (OR: 0.517, 95% CI: 0.428-0.763, P < .01; OR: 0.603, 95% CI: 0.415-0.699, P < .001; for IL-6 and TNF-alpha, respectively) was a protective factor.In our study, some abnormal pathological effects were found in asymptomatic young patients with hyperuricemia, suggesting that in young hyperuricemia patients, oxidative stress, inflammation and the inflammatory response may be related to the oxidative stress induced by UA. Uric Acid 55-57 interleukin 6 Homo sapiens 289-293 30544373-8 2018 Multivariable logistic regression analysis showed that UA (OR: 2.379, 95% CI: 1.698-3.286, P < .001; OR: 3.261, 95% CI: 1.729-3.857, P < .001; for IL-6 and TNF-alpha, respectively) and MDA (OR: 1.836, 95% CI: 1.283-2.517, P < .01; OR: 2.532, 95% CI: 1.693-3.102, P < .001; for IL-6 and TNF-alpha, respectively) were risk factors for high IL-6 and TNF-alpha and that SOD (OR: 0.517, 95% CI: 0.428-0.763, P < .01; OR: 0.603, 95% CI: 0.415-0.699, P < .001; for IL-6 and TNF-alpha, respectively) was a protective factor.In our study, some abnormal pathological effects were found in asymptomatic young patients with hyperuricemia, suggesting that in young hyperuricemia patients, oxidative stress, inflammation and the inflammatory response may be related to the oxidative stress induced by UA. Uric Acid 55-57 interleukin 6 Homo sapiens 289-293 30544373-8 2018 Multivariable logistic regression analysis showed that UA (OR: 2.379, 95% CI: 1.698-3.286, P < .001; OR: 3.261, 95% CI: 1.729-3.857, P < .001; for IL-6 and TNF-alpha, respectively) and MDA (OR: 1.836, 95% CI: 1.283-2.517, P < .01; OR: 2.532, 95% CI: 1.693-3.102, P < .001; for IL-6 and TNF-alpha, respectively) were risk factors for high IL-6 and TNF-alpha and that SOD (OR: 0.517, 95% CI: 0.428-0.763, P < .01; OR: 0.603, 95% CI: 0.415-0.699, P < .001; for IL-6 and TNF-alpha, respectively) was a protective factor.In our study, some abnormal pathological effects were found in asymptomatic young patients with hyperuricemia, suggesting that in young hyperuricemia patients, oxidative stress, inflammation and the inflammatory response may be related to the oxidative stress induced by UA. Uric Acid 55-57 interleukin 6 Homo sapiens 289-293 30607152-9 2018 Besides, the results of this study revealed that TSH treatment down-regulates TNF-alpha and IL-6. Thyrotropin 49-52 interleukin 6 Homo sapiens 92-96 30137596-8 2018 Pretreatment of arsenite-exposed cells with exogenous EGF, TGFalpha, NRG1, and HSP90 could promote, whereas exogenous IL-6 and NDRG1 could suppress, the phosphorylation of HER2. arsenite 16-24 interleukin 6 Homo sapiens 118-122 30119221-5 2018 TAK-242 (an inhibitor of TLR4) treatment or TLR4 knockdown attenuated LPS-induced expression and secretion of IL-6, IL-8 and MUC5 AC. ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate 0-7 interleukin 6 Homo sapiens 110-114 29969659-4 2018 Mechanistically, exposure to PLX4032 enhanced IL6 secretion and this, in turn, was responsible for STAT3 upregulation, activation of ERK signaling and poor sensitivity to BRAF inhibition. Vemurafenib 29-36 interleukin 6 Homo sapiens 46-49 29969659-5 2018 Consistently, the dual blockade of STAT3 (by siRNA or pharmacological inhibition) or IL6 signaling (by the humanized anti-human IL6 receptor antibody, tocilizumab) and BRAF (by PLX4032) improved the inhibition of cell cycle progression compared to PLX4032 single agent. Vemurafenib 177-184 interleukin 6 Homo sapiens 85-88 30216787-5 2018 Both olanzapine and aripiprazole stimulation decreased mRNA levels of IL-1beta, IL-6, and TNF-alpha and resulted in diminished protein concentrations of IL-6 and TNF-alpha in conditioned medium of stimulated PBMC. Olanzapine 5-15 interleukin 6 Homo sapiens 80-84 30216787-5 2018 Both olanzapine and aripiprazole stimulation decreased mRNA levels of IL-1beta, IL-6, and TNF-alpha and resulted in diminished protein concentrations of IL-6 and TNF-alpha in conditioned medium of stimulated PBMC. Olanzapine 5-15 interleukin 6 Homo sapiens 153-157 30216787-5 2018 Both olanzapine and aripiprazole stimulation decreased mRNA levels of IL-1beta, IL-6, and TNF-alpha and resulted in diminished protein concentrations of IL-6 and TNF-alpha in conditioned medium of stimulated PBMC. Aripiprazole 20-32 interleukin 6 Homo sapiens 80-84 30216787-5 2018 Both olanzapine and aripiprazole stimulation decreased mRNA levels of IL-1beta, IL-6, and TNF-alpha and resulted in diminished protein concentrations of IL-6 and TNF-alpha in conditioned medium of stimulated PBMC. Aripiprazole 20-32 interleukin 6 Homo sapiens 153-157 29928985-9 2018 The CD-based microparticles possessed more inhibitory effects on the viability of A549 cells and on the pro-inflammatory cytokines (TNF-alpha, IL-6 and IL-10) compared to the pure drug. betadex 4-6 interleukin 6 Homo sapiens 143-147 32254503-3 2018 The OECT gate electrode is functionalized with an oligo(ethylene glycol)-terminated self-assembled alkanethiolate monolayer (SAM) for both the immobilization of anti IL-6 antibodies and the inhibition of non-specific biomolecule binding. alkanethiolate 99-113 interleukin 6 Homo sapiens 166-170 29803543-10 2018 Interestingly, both NF-kappaB (quinazoline) and caspase-1 (VX-765) inhibitors suppressed the IL-32-related upregulation of pro-inflammatory cytokines (TNFalpha and IL-6). belnacasan 59-65 interleukin 6 Homo sapiens 164-168 30157804-12 2018 HMGB1, TNF-alpha, and IL-6 levels were significantly higher in RMPP cases compared with NRMPP cases (all p < 0.05). rmpp 63-67 interleukin 6 Homo sapiens 22-26 30126098-8 2018 Multiple linear regression, controlling for age and body mass index (BMI), demonstrated an inverse association between serum carotenoid concentrations and pro-inflammatory sTNFR-II (beta = 0.404, p = 0.005) and IL-6 concentrations (beta = -0.35, p = 0.001), but not IL-1ra or CRP. Carotenoids 125-135 interleukin 6 Homo sapiens 211-215 29527782-7 2018 Only in T1D boys serum UA was positively correlated with concentrations of subclinical inflammatory markers (CRP, IL-6, TNF-alpha), the indicators of renal function (albumin excretion rate, serum cystatin C level), blood pressure and negatively correlated with anti-inflammatory IL-10. Uric Acid 23-25 interleukin 6 Homo sapiens 114-118 30073204-7 2018 Treatment with LMWF5A caused a 50-70% decrease in IL-6 release throughout the dilution series. lmwf5a 15-21 interleukin 6 Homo sapiens 50-54 29396912-6 2018 The coating improved the retention and release efficacy of diclofenac and hence significantly inhibited interleukin-6 and tumor necrosis factor-alpha secretion from macrophages (p < 0.05). Diclofenac 59-69 interleukin 6 Homo sapiens 104-149 29748238-6 2018 Overexpression of miR-302e blocked PMA/A23187 or OVA induced the increase in inflammatory cytokines levels, such as IL-1beta, IL-6, tumor necrosis factor (TNF)-alpha and thymic stromal lymphopoietin, while miR-302 inhibition further promoted the release of these cytokines. Calcimycin 39-45 interleukin 6 Homo sapiens 126-130 34883342-5 2022 In contrast to IgE signaling, we show that fluvastatin augments IL-33-induced TNF and IL-6 production by mast cells. Fluvastatin 43-54 interleukin 6 Homo sapiens 86-90 28805137-8 2018 Furthermore, pre-incubation with CZP or IFX significantly inhibited the expression of mRNA for TNF-alpha and IL-6 in monocytes compared with PEG or IgG. Certolizumab Pegol 33-36 interleukin 6 Homo sapiens 109-113 34570917-17 2022 Both Amlexanox and BAY 11-7082 inhibited IFN-beta, TNF, and IL-6 production triggered by ISD and cyclic dinucleotides transfection. 3-(4-methylphenylsulfonyl)-2-propenenitrile 19-30 interleukin 6 Homo sapiens 60-64 29669302-7 2018 Sodium ascorbate exerts anti-inflammatory activity by reducing the expression of NFkappaB, CRP, TNF-alpha, IL-1beta and IL-6 associated with enhanced expression of the anti-inflammatory cytokines, IL-4 and IL-10. Ascorbic Acid 0-16 interleukin 6 Homo sapiens 120-124 34978772-5 2021 The anti-inflammatory effects of miR-181a-5p were evaluated by examining pro-inflammatory cytokines (interleukin (IL)-1beta, IL-6, tumor necrosis factor-alpha (TNF-alpha)) in the culture of RPMI-2650 cells stimulated by ovalbumin, using quantitative real-time reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay. mir-181a-5p 33-44 interleukin 6 Homo sapiens 125-129 29473951-7 2018 By contrast, low concentrations of 4-HNE, niacin and 3-OHBA down-regulated the expression of pro-inflammatory cytokines IL-6 and IL-8. Niacin 42-48 interleukin 6 Homo sapiens 120-124 29760703-9 2018 Furthermore, an AAT inhibitor l-aspartate-beta-hydroxamate (HDX), which blocked the upregulation of endogenous SO2/AAT generation induced by CSE knockdown, aggravated CSE knockdown-activated nuclear factor-kappaB pathway in the endothelial cells and its downstream inflammatory factors including ICAM-1, TNF-alpha, and IL-6. Sulfur Dioxide 111-114 interleukin 6 Homo sapiens 319-323 29998870-8 2018 In women, TNF-alpha had a significant positive association with total omega-3 (P <0.05) and omega-6 (P <0.01) PUFAs, IL-6 had a significant (P <0.05) positive association with total monounsaturated fatty acids and MCP-1 had a significant positive association with total trans-fatty acids (P <0.05). Fatty Acids, Monounsaturated 191-218 interleukin 6 Homo sapiens 123-127 34984290-5 2021 Similar results followed the exposure of IL-6 to N-chlorotaurine (NCT) and hypobromous acid (HOBr), two other reactive species produced in vivo. hypobromous acid 75-91 interleukin 6 Homo sapiens 41-45 32254344-6 2018 However, all the modified CS particles, in particular the OVA-modified ones (CS@OVA-13 and CS@OVA-65), induced significantly higher secretion of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) compared with the negative control. Chitosan 26-28 interleukin 6 Homo sapiens 189-202 34984290-5 2021 Similar results followed the exposure of IL-6 to N-chlorotaurine (NCT) and hypobromous acid (HOBr), two other reactive species produced in vivo. hypobromous acid 93-97 interleukin 6 Homo sapiens 41-45 32254344-6 2018 However, all the modified CS particles, in particular the OVA-modified ones (CS@OVA-13 and CS@OVA-65), induced significantly higher secretion of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) compared with the negative control. Chitosan 26-28 interleukin 6 Homo sapiens 204-208 29420357-6 2018 On reexamination, previously drug-naive AD patients who received donepezil treatment for 6 months displayed a decrease in cell-derived IFN-gamma, TNF-alpha, IL-1beta, and IL-6. Donepezil 65-74 interleukin 6 Homo sapiens 171-175 34984290-9 2021 Further studies on how HOCl and HOBr and their halogenated amine derivatives interact with IL-6 and related cytokines in vivo may open up alternative therapeutic interventions with these compounds in COVID-19 and other hyperinflammatory diseases. hypobromous acid 32-36 interleukin 6 Homo sapiens 91-95 34984290-9 2021 Further studies on how HOCl and HOBr and their halogenated amine derivatives interact with IL-6 and related cytokines in vivo may open up alternative therapeutic interventions with these compounds in COVID-19 and other hyperinflammatory diseases. Amines 59-64 interleukin 6 Homo sapiens 91-95 34948081-9 2021 The study on these molecules through RT-PCR confirmed that ETO-NE is significantly efficacious in mitigating the abundance of IL-B, IL-6, TNF, COX-2, and NF-kB as compared to the free ETO and control group. eto-ne 59-65 interleukin 6 Homo sapiens 132-136 29331857-7 2018 Baicalin alleviated IL-1beta-induced inflammatory injury, as it increased cell viability, decreased cell apoptosis and repressed the production of IL-6, IL-8 and TNF-alpha. baicalin 0-8 interleukin 6 Homo sapiens 147-151 29785114-9 2018 There was also a slight increase in the interleukin-6 (IL-6) level in the EABCF group (adjusted p=0.004). eabcf 74-79 interleukin 6 Homo sapiens 40-53 29785114-9 2018 There was also a slight increase in the interleukin-6 (IL-6) level in the EABCF group (adjusted p=0.004). eabcf 74-79 interleukin 6 Homo sapiens 55-59 34731780-6 2021 CONCLUSION: The present findings demonstrated that methotrexate does not predispose patients to severe COVID-19; on the contrary, patients taking methotrexate may experience a milder disease, possibly due to their reduced severe inflammatory reactions as a result of inhibited TNFalpha, lowered IL6, and increased T regulatory cells. Methotrexate 51-63 interleukin 6 Homo sapiens 295-298 29735019-6 2018 RESULTS: EPA+DHA therapy had a significant lowering effect on levels of IL-6, IL-1beta and TNF-alpha after 4 weeks of therapy and an even greater lowering effect after 8 weeks of therapy. Eicosapentaenoic Acid 9-12 interleukin 6 Homo sapiens 72-76 29288516-8 2018 In conclusion, our results elucidate that interleukin-6/STAT3 activation can increase PTTG1 expression and, consequently, promote the resistance to ADT in CRPC by inducing EMT and increasing the cancer stem cell population, suggesting that PTTG1 may be a novel therapeutic target for CRPC. adt 148-151 interleukin 6 Homo sapiens 42-55 29695657-12 2018 In conclusion, we propose that the combination of IL-6 -572C/G and ICAM-1 K469E polymorphisms have a synergistic effect on the onset of SSNHL. ssnhl 136-141 interleukin 6 Homo sapiens 50-54 28946308-3 2018 AAMP-A70 increases macrophage phagocytosis and secretion of NO, ROS, TNF-alpha, IL-6 and IL-1beta. aamp-a70 0-8 interleukin 6 Homo sapiens 80-84 34731780-6 2021 CONCLUSION: The present findings demonstrated that methotrexate does not predispose patients to severe COVID-19; on the contrary, patients taking methotrexate may experience a milder disease, possibly due to their reduced severe inflammatory reactions as a result of inhibited TNFalpha, lowered IL6, and increased T regulatory cells. Methotrexate 146-158 interleukin 6 Homo sapiens 295-298 28840599-5 2018 Here, we show that BTs alter the secretion of IL-6 from increasingly reconstituted preparations of human immune cells. bts 19-22 interleukin 6 Homo sapiens 46-50 34624807-9 2021 CONCLUSION: This systematic review broadly reports that, in contrast to other classes of phytochemicals, flavonoids have the greatest therapeutic potential against arthritis by modulating the expression of pro-inflammatory TNF-alpha, IL-1beta, IL-6, IL-8, and IL-17, as well as anti-inflammatory IL-2 and IL-10 cytokines, through the suppression of dynamic inflammatory biomarkers. Flavonoids 105-115 interleukin 6 Homo sapiens 244-248 28840599-7 2018 The results indicated that both BTs altered IL-6 secretion from all cell preparations. bts 32-35 interleukin 6 Homo sapiens 44-48 29350882-10 2018 NT-proBNP in the acute and subacute phases correlated with sTNFR1 (r = 0.63/0.43, P < 0.01), sTNFR2 (r = 0.50/0.31, P < 0.05), and interleukin-6 (r = 0.58/0.43, P < 0.01). nt-probnp 0-9 interleukin 6 Homo sapiens 137-150 29161660-7 2018 In addition, pretreatment with AST2017-01 or chrysophanol significantly decreased the PMACI-induced levels of interleukin (IL)-1beta, IL-6, tumor necrosis factor-alpha, and thymic stromal lymphopoietin (TSLP) on HMC-1 cells. chrysophanic acid 45-57 interleukin 6 Homo sapiens 134-138 34885115-15 2021 CAFs derived from Osimertinib-resistant cells secreted more IL-6, IL-8, and hepatocyte growth factor (HGF), expressed stronger CAF markers including alpha-smooth muscle actin (alpha-SMA), fibroblast activation protein (FAP) plus platelet-derived growth factor receptor (PDGFR), and enhanced stemness and Osimertinib resistance in NSCLC cells. osimertinib 18-29 interleukin 6 Homo sapiens 60-64 29924262-5 2018 RESULTS: Levels of IL-1beta and IL-6 were found to be increased in patients with DENV vs. the healthy controls. denv 81-85 interleukin 6 Homo sapiens 32-36 29615908-7 2018 Acetate, butyrate and propionate reduced IL-6 and IL-8 levels and the magnitude was dependent on the incubation times. Acetates 0-7 interleukin 6 Homo sapiens 41-45 29615908-12 2018 Conclusion: SCFA, including acetate, butyrate and propionate, influenced LPS- or TNFalpha-induced endothelial activation by inhibiting the production of IL-6 and IL-8, and reducing the expression of VCAM-1 and subsequent cell adhesion. Acetates 28-35 interleukin 6 Homo sapiens 153-157 34834040-5 2021 In addition, quercetin suppressed the nuclear translocation of nuclear factor kappa B (NF-kappaB) and reduced levels of inflammatory cytokine tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, and IL-6, which had increased significantly after LPS exposure. Quercetin 13-22 interleukin 6 Homo sapiens 201-205 29329391-10 2018 Additionally, AM1241 delayed early activation of monocytes and induced suppression of IL-2 and IL-6 levels in response to Candida via lower activity of mammalian target of rapamycin (mTOR). AM 1241 14-20 interleukin 6 Homo sapiens 95-99 29230430-7 2018 IL-1beta, IL-6 and TNF-alpha was only significantly increased in cultures exposed to 500 muM TEGDMA. triethylene glycol dimethacrylate 93-99 interleukin 6 Homo sapiens 10-14 29230430-10 2018 Conclusions: TEGDMA affects production of proinflammatory cytokines IL-1beta, IL-6, IL-8, IL-18 and TNF-alpha. triethylene glycol dimethacrylate 13-19 interleukin 6 Homo sapiens 78-82 34755560-1 2021 OBJECTIVE: To explore whether dihydroartemisinin (DHA) can block interleukin (IL)-6-induced epithelial-mesenchymal transition (EMT) in laryngeal squamous cell carcinoma (LSCC). artenimol 30-48 interleukin 6 Homo sapiens 65-83 29454966-9 2018 The involvement of the IL-6 and GS suggests that the SCG2 may potentially regulate inflammatory factors and excitatory neurotransmitter to the cytotoxicity of PQ on astroglia. Paraquat 159-161 interleukin 6 Homo sapiens 23-27 29274621-5 2018 The hypothesis of this study was that cannabinoids anandamide (AEA), HU-308 (CB2R selective agonist), and SMM-189 decrease pro-inflammatory IL-6 and MCP-1 production by primary human periodontal ligament fibroblasts (hPDLFs) stimulated with P. gingivalis LPS, TNF-alpha, or IL-1beta. Cannabinoids 38-50 interleukin 6 Homo sapiens 140-144 29285177-8 2017 The results demonstrated that after Simvastatin treatment of patients with acute cerebral hemorrhage at the ICU, the plasma concentrations of IL-4, IL-6, IL-8 and IL-10 were downregulated compared with those in placebo-treated controls. Simvastatin 36-47 interleukin 6 Homo sapiens 148-152 34755560-1 2021 OBJECTIVE: To explore whether dihydroartemisinin (DHA) can block interleukin (IL)-6-induced epithelial-mesenchymal transition (EMT) in laryngeal squamous cell carcinoma (LSCC). artenimol 50-53 interleukin 6 Homo sapiens 65-83 28858391-5 2018 Results showed that EPS significantly inhibited the upregulation of matrix metalloproteinases and IL-6 caused by UVB irradiation, and suppressed UVB-induced phosphorylation of extracellular signal-regulated kinase, Jun N-terminal kinase and p38, as well as the activation of AP-1 transcription factors. exophthalmos producing substance 20-23 interleukin 6 Homo sapiens 98-102 34755560-6 2021 Furthermore, DHA upregulated miR-130b-3p, which can downregulate STAT3 and beta-catenin protein expression and decrease the activity of the IL-6/STAT3 signaling pathway. artenimol 13-16 interleukin 6 Homo sapiens 140-144 34755560-8 2021 CONCLUSIONS: DHA can block IL-6-triggered EMT and invasion in LSCC, and during these processes, DHA increases miR-130b-3p expression to decrease the activation of the IL-6/STAT3 and beta-catenin signaling pathways. artenimol 13-16 interleukin 6 Homo sapiens 27-31 34755560-8 2021 CONCLUSIONS: DHA can block IL-6-triggered EMT and invasion in LSCC, and during these processes, DHA increases miR-130b-3p expression to decrease the activation of the IL-6/STAT3 and beta-catenin signaling pathways. artenimol 13-16 interleukin 6 Homo sapiens 167-171 30381011-10 2018 In group TEAS, the serum levels of TNF-alpha were lower at T1 to T5, while the levels of IL-6 were lower at T2 to T5. Silicon triethanolamine 9-13 interleukin 6 Homo sapiens 89-93 28683358-7 2017 AFBN patients showed higher serum levels of IFN-gamma, IL-6, IL-10 and soluble TNF-receptor 1 (sTNFR1) (all p<0.05). afbn 0-4 interleukin 6 Homo sapiens 55-59 30381011-12 2018 The application of TEAS can effectively reverse the decrease in NK cells, decrease the serum levels of TNF-alpha and IL-6, maintain hemodynamic stability during the perioperative period, decrease the consumption of propofol and remifentanil, and shorten the length of the hospital stay. Silicon triethanolamine 19-23 interleukin 6 Homo sapiens 117-121 34755560-8 2021 CONCLUSIONS: DHA can block IL-6-triggered EMT and invasion in LSCC, and during these processes, DHA increases miR-130b-3p expression to decrease the activation of the IL-6/STAT3 and beta-catenin signaling pathways. artenimol 96-99 interleukin 6 Homo sapiens 27-31 34755560-8 2021 CONCLUSIONS: DHA can block IL-6-triggered EMT and invasion in LSCC, and during these processes, DHA increases miR-130b-3p expression to decrease the activation of the IL-6/STAT3 and beta-catenin signaling pathways. artenimol 96-99 interleukin 6 Homo sapiens 167-171 34791846-12 2021 CONCLUSIONS: The active ingredients of Kushen Decoction, such as quercetin, (+)-14alpha-hydroxymatrine and apigenin, may act on targets like AKT1, TNF, IL-6 to modulate TLR, NLR and NF-kappaB signaling pathways to play a synergistic role in the treatment of cryptosporidiosis in the hematologic and immune system. Quercetin 65-74 interleukin 6 Homo sapiens 152-156 29696035-6 2018 The levels of IL-6 significantly decreased in the CRHF and CRLC groups (changes from baseline values in simple advice, CRHF, and CRLC were 7.5 +- 6.8, -1.2 +- 4.7, and -4.2 +- 5.6 pg/mL, respectively). crhf 50-54 interleukin 6 Homo sapiens 14-18 29696035-6 2018 The levels of IL-6 significantly decreased in the CRHF and CRLC groups (changes from baseline values in simple advice, CRHF, and CRLC were 7.5 +- 6.8, -1.2 +- 4.7, and -4.2 +- 5.6 pg/mL, respectively). crhf 119-123 interleukin 6 Homo sapiens 14-18 29126272-8 2017 Vitamin C also facilitated induction of a FOXP3high iTreg population from human naive T cells, which was very stable even in the presence of IL-6 in vitro. Ascorbic Acid 0-9 interleukin 6 Homo sapiens 141-145 29594564-0 2017 Photoelectrochemical immunoassay for human interleukin 6 based on the use of perovskite-type LaFeO3 nanoparticles on fluorine-doped tin oxide glass. perovskite 77-87 interleukin 6 Homo sapiens 43-56 29149986-8 2017 MAIN FINDINGS: A significant increase in IL-6 (mRNA and released protein) was observed in the presence of FK-506 and RAPA. Tacrolimus 106-112 interleukin 6 Homo sapiens 41-45 28601733-1 2017 AIM: The present study was carried out to evaluate the effect of 1.2% simvastatin gel as local drug delivery (LDD) system on Gingival Crevicular Fluid (GCF) Interleukin -6 (IL-6) and Interleukin-8 (IL-8) levels in chronic periodontitis patients, in addition to scaling and root planing (SRP). Simvastatin 70-81 interleukin 6 Homo sapiens 157-171 28601733-1 2017 AIM: The present study was carried out to evaluate the effect of 1.2% simvastatin gel as local drug delivery (LDD) system on Gingival Crevicular Fluid (GCF) Interleukin -6 (IL-6) and Interleukin-8 (IL-8) levels in chronic periodontitis patients, in addition to scaling and root planing (SRP). Simvastatin 70-81 interleukin 6 Homo sapiens 173-177 28697464-5 2017 C2C12 myobalsts showed a significant increase in VEGF production and decrease in IL-6 production on LM-111 enriched fibrin hydrogels as compared to pure fibrin hydrogels on day 4. lm-111 100-106 interleukin 6 Homo sapiens 81-85 29594564-5 2017 Graphical abstract Schematic of a novel photoelectochemical immunoassay for the measurement of IL-6 based on perovskite-type LaFeO3 nanoparticles. perovskite 109-119 interleukin 6 Homo sapiens 95-99 34633041-10 2022 ESM-HDAC528 inhibited LPS-stimulated IL-6 and TNF-alpha production 1000 times more potently than its control, HDAC800, in CES1 high monocytes. esm-hdac528 0-11 interleukin 6 Homo sapiens 37-41 28735510-8 2017 Addition of rivaroxaban to AAA sites explants significantly reduced the release of interleukin-6 [median: 51.61 (interquartile range: 30.87-74.03) pg ml-1 mg tissue-1 , P < 0.05 with respect to AAA alone] and the content of nitric oxide synthase 2, gp67 and gp91-phox NADPH subunits. Rivaroxaban 12-23 interleukin 6 Homo sapiens 83-96 28427103-12 2017 Interestingly, saffron flower acetone extract further increased IL-6 levels in TNF-alpha-treated HaCaT cells in a concentration-dependent manner. saffron flower acetone 15-37 interleukin 6 Homo sapiens 64-68 34635132-9 2021 Although flaxseed oil supplementation had no such lowering-effect on lipid, meta-analysis revealed its lowering-effect on IL-6 (- 0.35 pg/ml, P = 0.033) and hs-CRP (- 1.54 mg/l, P = 0.004). Linseed Oil 9-21 interleukin 6 Homo sapiens 122-126 29254155-4 2017 Casticin decreased levels of IL-6, tumor necrosis factor alpha, and IL-8 and suppressed COX-2 expression and prostaglandin E2 production. casticin 0-8 interleukin 6 Homo sapiens 29-33 28683358-11 2017 IFN-gamma and IL-6 levels might most effectively distinguish AFBN from APN. afbn 61-65 interleukin 6 Homo sapiens 14-18 34660782-11 2021 This study revealed that SZRD has the characteristics and advantages of "multicomponent, multitarget, and multipathway" in the treatment of PDSD; among these, the combination of the main active components of quercetin and kaempferol with the key targets of AKT1, IL6, MAPK1, TP53, and VEGFA may be one of the important mechanisms. Quercetin 208-217 interleukin 6 Homo sapiens 263-266 28229387-8 2017 With respect to either CeO2-A coating or Ti substrate, the CeO2-B coating exerted greater effects on the macrophages, increasing the anti-inflammatory cytokines (IL-10 and IL-1ra) expression and suppressing the expression of the pro-inflammatory cytokines (TNF-alpha and IL-6) and ROS production. ceo2-b 59-65 interleukin 6 Homo sapiens 271-275 28524237-8 2017 IL-6 plasma concentrations were markedly lower with HCO and MCO dialysis. hco 52-55 interleukin 6 Homo sapiens 0-4 34097069-1 2021 OBJECTIVE: This study was designed to explore the efficacy and feasibility of cognitive behavioural therapy(CBT) along with pregabalin and compare it with pregabalin monotherapy for the management of neuropathic pain in post-herpetic neuralgia (PHN) patients and to explore the modulation of mRNA expression of interleukin (IL)-6 and mammalian target of rapamycin-1 (mTORC1) genes in these patients. Pregabalin 124-134 interleukin 6 Homo sapiens 311-329 28713941-5 2017 Celecoxib and simvastatin alone as well as a combined treatment showed a significant reduction in tumor cell viability, proliferation and secretion of IL-6 and IL-8 compared to the control group. Simvastatin 14-25 interleukin 6 Homo sapiens 151-155 28821005-8 2017 This cannabinoid also prevented PTZ-induced EEG activity and interleukin-6 increase in prefrontal cortex. Cannabinoids 5-16 interleukin 6 Homo sapiens 61-74 34097069-12 2021 Following integrated approach encompassing CBT and Pregabalin, group CP had significant downregulation of mRNA expression of IL-6; however, no such correlation was observed with mTOR expression. Pregabalin 51-61 interleukin 6 Homo sapiens 125-129 34691080-8 2021 Baseline endo-EV IFN-gamma and exo-EV IL-6 concentrations were also associated with rOA progression, but had low discriminant capacity (AUCs 0.558 and 0.518, respectively). ROA 84-87 interleukin 6 Homo sapiens 38-42 28606428-4 2017 TiO2 particles at 10mug/ml showed increased mRNA expression of inflammatory cytokines (TNFalpha, IL-1beta and IL-6), inflammatory mediators (iNOS and COX-2) and transcription factor (NFkappaB) similar to that of LPS stimulated macrophages. titanium dioxide 0-4 interleukin 6 Homo sapiens 110-114 28606428-6 2017 In addition, TiO2 particles at 10mug/ml also increased the production of inflammatory cytokines (TNFalpha, IL-1beta and IL-6) and intracellular ROS levels in RAW 264.7 macrophages similar to that of LPS stimulated macrophages. titanium dioxide 13-17 interleukin 6 Homo sapiens 120-124 28510700-9 2017 Furthermore, GPLE significantly inhibited the production of TNF-alpha and IL-6 cytokines compared with PLE in phorbol 12-myristate 13-acetate (PMA) plus A23187-stimulated HMC-1 human mast cells. Calcimycin 153-159 interleukin 6 Homo sapiens 74-78 28955792-2 2017 Here, we showed a plant polyphenol, kaempferol, attenuated IL-6-induced COX-2 expression in human monocytic THP-1 cells suggesting its beneficial role in chronic inflammation. kaempferol 36-46 interleukin 6 Homo sapiens 59-63 34558232-3 2022 MM cells are mono-cultured or co-cultured with HS5 stromal cells that can release interleukin-6 (IL-6), where the cells show superior behaviors and responses to bortezomib in 3D models than in the planar cultures. Bortezomib 161-171 interleukin 6 Homo sapiens 82-95 28798905-11 2017 Regardless of the T. gondii strain, BeWo cells infected and treated with enrofloxacin or toltrazuril induced high levels of IL-6 and MIF. Enrofloxacin 73-85 interleukin 6 Homo sapiens 124-128 29218943-15 2017 The contents of PAI-1, ET-1, IL-6, TNF-alpha, TXB2, LDH, MDA, Bax mRNA and Caspase-3 mRNA expressions were lower after treated with germacrone. germacrone 132-142 interleukin 6 Homo sapiens 29-33 28844118-5 2017 In the ex vivo experiment, the geometric means (SD) of the ratio of MDCO-216 stimulated IL-6 over background levels were 0.8 (1.9), 0.7 (1.5), 1.0 (2.0) for respectively HV, sCAD, aCAD. mdco 68-72 interleukin 6 Homo sapiens 88-92 28477980-12 2017 In vivo studies indicated that the expression of SIRT1, SIRT6 was decreased and the expression of MCP-1, IL-6 and IL-1beta was increased in carotid collar-induced vascular inflammation. carotid 140-147 interleukin 6 Homo sapiens 105-109 28534957-6 2017 Pretreatment with GSP before LPS treatment significantly suppressed the mRNA expression of pro-inflammatory cytokines such as IL-1beta, IL-6 and IL-8. Grape Seed Proanthocyanidins 18-21 interleukin 6 Homo sapiens 136-140 34558232-3 2022 MM cells are mono-cultured or co-cultured with HS5 stromal cells that can release interleukin-6 (IL-6), where the cells show superior behaviors and responses to bortezomib in 3D models than in the planar cultures. Bortezomib 161-171 interleukin 6 Homo sapiens 97-101 28444390-10 2017 SMX-NO/flucloxacillin stimulated secretion of TNF-alpha, IL-6, IL-1alpha, and IL-1-beta. 4-nitrososulfamethoxazole 0-6 interleukin 6 Homo sapiens 57-61 34551795-11 2021 Although GTE improved fasting blood sugar and insulin levels, the effect of GTE on inflammatory parameters, such as TNF-alpha and IL-6 and antioxidant status, was limited to animal studies. gte 76-79 interleukin 6 Homo sapiens 130-134 28526382-6 2017 RESULTS: MAR and NAR scores for phosphorus; vitamins A, B1, and B6; and niacin were negatively associated with IL-6 (beta = -0.006, -0.004, -0.004, -0.007, -0.004, and -0.005, respectively; P < 0.05). Niacin 72-78 interleukin 6 Homo sapiens 111-115 28499250-12 2017 The ox-LDLs and endo-PF treatment also produced significant overexpression of microRNA predicted target genes nerve growth factor, interleukin-6 and prostaglandin E synthase and overexpression of their downstream protein targets Mip1alpha and MCP1. endo-pf 16-23 interleukin 6 Homo sapiens 131-144 28396833-11 2017 HMGB1, sRAGE, IL6 and TGFbeta1 levels in BALF were also reduced by baicalin treatment. baicalin 67-75 interleukin 6 Homo sapiens 14-17 34703647-0 2021 HIF1A-AS2 induces osimertinib resistance in lung adenocarcinoma patients by regulating the miR-146b-5p/IL-6/STAT3 axis. osimertinib 18-29 interleukin 6 Homo sapiens 103-107 28396833-13 2017 Furthermore, expression levels of HMGB1, RAGE, IL6 and TGFbeta1 in lung tissue were dramatically decreased by baicalin in a dosage-dependent manner. baicalin 110-118 interleukin 6 Homo sapiens 47-50 28000839-11 2017 Sulfated glycosaminoglycan production was also reduced upon chondrogenic differentiation in the presence of IL-6, but not IL-8. Glycosaminoglycans 9-26 interleukin 6 Homo sapiens 108-112 27828735-6 2017 Iohexol and Urografin also caused a significant increase in NF-kappaB followed by the release of IL-6 and MCP-1. Diatrizoate Meglumine 12-21 interleukin 6 Homo sapiens 97-101 28757040-2 2017 Previous studies demonstrated that PPV infection induced significant production of interleukin 6 (IL-6) in vitro and in vivo. DOP protocol 35-38 interleukin 6 Homo sapiens 83-96 28757040-2 2017 Previous studies demonstrated that PPV infection induced significant production of interleukin 6 (IL-6) in vitro and in vivo. DOP protocol 35-38 interleukin 6 Homo sapiens 98-102 34493195-7 2022 RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients. Quercetin 101-110 interleukin 6 Homo sapiens 251-254 28408143-7 2017 Both tetrandrine and methylprednisolone inhibited the secretion of pro-inflammatory cytokines TNFalpha and IL-6 significantly and the combination showed stronger inhibitory ability. tetrandrine 5-16 interleukin 6 Homo sapiens 107-111 28514348-9 2017 Thus the age-dependent trend for the increase of leukocytes count in OL and pro-inflammatory cytokine IL-6 with the decrease of anti-inflammatory cytokine IL-4 is noted in children with CCG living in EPR. cationic colloidal gold 186-189 interleukin 6 Homo sapiens 102-106 34479552-11 2021 CONCLUSIONS: Luteoklin, quercetin, kaempferol and other active compounds in Epicedium can regulate multiple signaling pathways and targets such as IL6, AKT1, and EGF, therefore playing therapeutic roles in depression. Quercetin 24-33 interleukin 6 Homo sapiens 147-150 34420445-9 2021 Interestingly, IL-6 was increased at 20 h after HIFU in PaC patients. hifu 48-52 interleukin 6 Homo sapiens 15-19 27980405-7 2016 Interleukin (IL)-1beta, IL-6, and transforming growth factor-beta expression decreased significantly in the PCL group compared with the control. polycaprolactone 108-111 interleukin 6 Homo sapiens 24-28 28051250-7 2016 MiR-365 may regulate the pathogenesis and immune response in AS through targeting IL-6. mir-365 0-7 interleukin 6 Homo sapiens 82-86 28527371-3 2017 Here, we first assessed relationships between interleukin (IL)-6 and individual carotenoids in plasma from CAD patients. Carotenoids 80-91 interleukin 6 Homo sapiens 46-64 28558744-2 2017 Recently there are few reports pointing out that tocilizumab(TCZ), an anti IL-6 agent may be effective in AA amyloidosis resistant to conventional treatments. tioconazole 61-64 interleukin 6 Homo sapiens 75-79 34484339-0 2021 Effect of Entecavir Combined with Adefovir Dipivoxil on Clinical Efficacy and TNF-alpha and IL-6 Levels in Patients with Hepatitis B Cirrhosis. adefovir dipivoxil 34-52 interleukin 6 Homo sapiens 92-96 34484339-1 2021 Objective: The purpose of the study was to investigate the effect of entecavir combined with adefovir dipivoxil on clinical efficacy and TNF-alpha and IL-6 levels in patients with hepatitis B cirrhosis. adefovir dipivoxil 93-111 interleukin 6 Homo sapiens 151-155 27575568-6 2016 As a result from the inflammatory response, IPOH [50muM] induced an increase of both IL-6 and IL-8 secretion in A549 (1.5-fold change) and in 16HBE14o- (2.8- and 7-fold change respectively). ipoh 44-48 interleukin 6 Homo sapiens 85-89 34408814-6 2021 Results: H2S triggered the secretion of the pro-inflammatory IFN-gamma, IL-6, IL-17, TNF-alpha, IL-12p40, and IL-12p70, while the reverse was seen for IL-1Ra. Deuterium 9-12 interleukin 6 Homo sapiens 72-76 28278436-9 2017 The results of the in vitro and in vivo experiments indicated that the levels of LPS, TNF-alpha and IL-6 of the palmatine group were significantly lower than those of the sepsis model group (p<0.01). palmatine 112-121 interleukin 6 Homo sapiens 100-104 27768523-6 2017 Acetaminophen and ibuprofen were used to block the effect of IL-6 at a central and peripheral level, respectively. Acetaminophen 0-13 interleukin 6 Homo sapiens 61-65 27849062-4 2016 Herein, we show that FTY720-P enhances TNF-induced PP2A phosphatase activity and significantly represses TNF-induced interleukin 6 (IL-6) and IL-8 mRNA expression and protein secretion from A549 lung epithelial cells. FTY 720P 21-29 interleukin 6 Homo sapiens 132-136 34089945-5 2021 In addition, the most potent derivatives 2a and 2d inhibited the oncogenic function of STAT3 as seen in the inhibition of colony formation and IL-6 production of breast cancer cell lines. 2A 41-43 interleukin 6 Homo sapiens 143-147 27819273-0 2016 Neovestitol, an isoflavonoid isolated from Brazilian red propolis, reduces acute and chronic inflammation: involvement of nitric oxide and IL-6. neovestitol 0-11 interleukin 6 Homo sapiens 139-143 34102301-8 2021 Besides, the production of IL-6 in LPS/IFN-gamma induced THP-1 cells was also decreased by both nucleosides. Nucleosides 96-107 interleukin 6 Homo sapiens 27-31 27819273-10 2016 In addition, pretreatment with neovestitol reduced the levels of IL-6. neovestitol 31-42 interleukin 6 Homo sapiens 65-69 28099874-13 2017 IL-6 elevation from 35 dpi may be indicative of parasite neuroinvasion hence can be used as possible candidate marker for late stage disease in the monkey model. 3-aminodiphenyleneiodium 23-26 interleukin 6 Homo sapiens 0-4 34282217-8 2021 DZA treatment also significantly reduced adipocyte differentiation factors, impaired adiponectin and leptin secretion but increased release of pro-inflammatory cytokines, IL-6, TNF and MCP-1. 3-deazaadenosine 0-3 interleukin 6 Homo sapiens 171-175 28129624-9 2017 What"s more, we examined that Erianin might play its role in angiogenesis through down-regulating phosphorylation of JAK2/STAT3, inhibiting its downstream target genes MMP-2/-9 and some inflammatory mediators (COX-2, HIF-1alpha and IL-6), which were all induced by IDO. Erianin 30-37 interleukin 6 Homo sapiens 232-236 27003335-8 2017 Treatment with simvastatin significantly attenuated LPS-stimulated production of IL-1beta, IL-6, VCAM-1 and ICAM-1 (P < 0.05). Simvastatin 15-26 interleukin 6 Homo sapiens 91-95 27892672-10 2016 Conclusions: It seems thatreducing the level of copper in the diet and dosing with penicillamine leads to decline of angiogenesis-related factorssuch as VEGF, IL-6 and TNF-alpha. Penicillamine 83-96 interleukin 6 Homo sapiens 159-163 27699014-7 2016 Patients that received acarbose plus insulin demonstrated greater reduction in 8-iso PGF2alpha, Hs-CRP, TNF-alpha, IL-1beta and IL-6 levels when compared with the insulin only patients. Acarbose 23-31 interleukin 6 Homo sapiens 128-132 34377263-4 2021 RESULTS: Similar expression levels of carcinoembryonic antigen, IL-6, carbohydrate antigen 125, TNF-alpha, carbohydrate antigen 153 and immunoglobulin were found in the control group and pemetrexed group before treatment (all P>0.05). Pemetrexed 187-197 interleukin 6 Homo sapiens 64-68 26189429-5 2016 We find that vemurafenib anti-BRAF(V600E) therapy significantly reduces secreted VEGFA, VEGFC and IL6 protein levels compared to vehicle-treated ATC cells. Vemurafenib 13-24 interleukin 6 Homo sapiens 98-101 28081470-7 2017 The expression level of cytokines and chemokines influenced by eleutheroside B1 was further demonstrated, the IL-6, CXCL-8, CCL-2 expression were all inhibited by the eleuthe roside B1 at concentration 200mug/ml. Eleutheroside B1 63-79 interleukin 6 Homo sapiens 110-114 28081470-7 2017 The expression level of cytokines and chemokines influenced by eleutheroside B1 was further demonstrated, the IL-6, CXCL-8, CCL-2 expression were all inhibited by the eleuthe roside B1 at concentration 200mug/ml. eleuthe roside b1 167-184 interleukin 6 Homo sapiens 110-114 34353059-16 2021 Its active compounds, including quercetin and kaempferol, can exert their therapeutic effects on OA by acting on TNF, PTGS2, MMP2, IL-6, IL-1beta, and other key targets to regulate inflammation, immunity, autophagy, and endocrine-related signaling pathways. Quercetin 32-41 interleukin 6 Homo sapiens 131-135 27501348-1 2016 The cobalt(II) complexes with the quinolone sparfloxacin (Hsf) in the absence or presence of the nitrogen-donor heterocyclic ligands 2,2"-bipyridine (bipy), 1,10-phenanthroline (phen) or 2,2"-bipyridylamine (bipyam) were prepared and characterized physicochemically and spectroscopically. Cobalt(2+) 4-14 interleukin 6 Homo sapiens 58-61 34323408-4 2021 Mechanistically, cytoplasmic IL6-AS1 acts as an endogenous sponge by competitively binding to the microRNA miR-149-5p to stabilize IL-6 mRNA. mir-149-5p 107-117 interleukin 6 Homo sapiens 29-32 27994808-9 2016 CONCLUSION: The cytotoxic effects of B(e)p include elevated ROS/RNS levels along with pro-inflammatory IL-6 and GM-CSF proteins. benzo(e)pyrene 37-42 interleukin 6 Homo sapiens 103-107 27271301-4 2016 After three weeks the E MTX + DOLE group maintained high catalase activity, exhibited decrease of lipid peroxidation and protein damage indicators-thiols and nitrites, while levels of DNA damage and pro-inflammatory interleukin-6 were significantly reduced. Ethyl (E)-3,5-dihydroxy-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-hept-6-enoate 30-34 interleukin 6 Homo sapiens 216-229 27271301-7 2016 Combined administration of DOLE with MTX contributes to faster reduction of cell damage, restores oxidative balance and improves interleukin-6 suppression during high disease activity in early phase RA, but not in long term patients. Ethyl (E)-3,5-dihydroxy-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-hept-6-enoate 27-31 interleukin 6 Homo sapiens 129-142 27913196-10 2017 In addition, miR-155, IL-6, and IL-8 were over-expressed in the serum of arsenite exposure group. arsenite 73-81 interleukin 6 Homo sapiens 22-26 28128374-9 2017 After stimulating MDM with the potent pro-inflammatory agent LPS, pPLLA and poly(l-lysine) and fibronectin-modified films reveal a significant reduction in IL-6 secretion, while the opposite effect is observed with IL-10. poly(l-lysine 76-89 interleukin 6 Homo sapiens 156-160 34323408-4 2021 Mechanistically, cytoplasmic IL6-AS1 acts as an endogenous sponge by competitively binding to the microRNA miR-149-5p to stabilize IL-6 mRNA. mir-149-5p 107-117 interleukin 6 Homo sapiens 131-135 27598116-5 2016 IL-6 levels in the HMC-1 stimulated by phorbol-12-myristate-13-acetate and A23187 were apparently decreased by the treatment of atractylodin. Calcimycin 75-81 interleukin 6 Homo sapiens 0-4 34175381-5 2021 MTX-PG induces several pro-inflammatory signaling pathways and cytokines such as tumor necrosis factor-alpha, nuclear factor kappa B and interleukin 6 (IL-6), IL- beta1, IL-12. mtx-pg 0-6 interleukin 6 Homo sapiens 137-150 27986128-10 2016 In addition, serum TSH levels showed a correlation for waist circumference, weight, BMI, A1c, insulin, IL-6, leptin, ICAM-1 and E-selectin. Thyrotropin 19-22 interleukin 6 Homo sapiens 103-107 28192516-0 2017 Correction: Atorvastatin, Losartan and Captopril Lead to Upregulation of TGF-beta, and Downregulation of IL-6 in Coronary Artery Disease and Hypertension. Captopril 39-48 interleukin 6 Homo sapiens 105-109 34175381-5 2021 MTX-PG induces several pro-inflammatory signaling pathways and cytokines such as tumor necrosis factor-alpha, nuclear factor kappa B and interleukin 6 (IL-6), IL- beta1, IL-12. mtx-pg 0-6 interleukin 6 Homo sapiens 152-156 34221091-11 2021 Additionally, the patients in the PCI + tirofiban group had lower levels of CRP, TNF-alpha, IL-6, and PCT compared with those in the PCI group at days 7 and 30 post-PCI (P < 0.05). Tirofiban 40-49 interleukin 6 Homo sapiens 92-96 28367234-5 2017 Treatment of oral tumors with sulindac, but not adriamycin inversely modulates the expression and function of NFkappaB and JNK, resulting in a significant down-regulation of IL-6, and VEGF secretion by oral tumor cells. Sulindac 30-38 interleukin 6 Homo sapiens 174-178 28367234-6 2017 In addition, increased secretion of IL-6 and VEGF is blocked by sulindac during interaction of oral tumors with NK cells. Sulindac 64-72 interleukin 6 Homo sapiens 36-40 27043920-12 2016 In addition, baicalin also inhibited the productions of inflammatory cytokines such as IL-1beta, IL-6, IL-8 and TNF-alpha and suppressed the phosphorylation of JAK2, STAT5, IKKbeta, IkappaBalpha and the nuclear translocation of NF-kappaB (p65) subunit in LPS-stimulated human mast cells. baicalin 13-21 interleukin 6 Homo sapiens 97-101 34348637-6 2021 Additionally, triterpene acid mixture (ursolic acid, oleanolic acid, and betulinic acid), also isolated from rosehip, has been reported to reduce the production of interleukin-6 and Tumor necrosis factor-alpha. Oleanolic Acid 53-67 interleukin 6 Homo sapiens 164-177 28043032-12 2017 In addition, kaempferol alleviated inflammatory by reducing the level of pro-inflammatory cytokines (i.e., interleukin (IL)-6) and increasing anti-inflammatory cytokine (IL-10) via inhibiting the nucleus translocation of nuclear transcription factor (NF)-kappaB p65. kaempferol 13-23 interleukin 6 Homo sapiens 107-125 34340239-15 2021 CONCLUSIONS: The high-concentration methylmalonic acid in the blood induced immune cells to release pro-inflammatory cytokines such as TNF-alpha and IL-6. Methylmalonic Acid 36-54 interleukin 6 Homo sapiens 149-153 28194150-0 2016 Epigenetic Regulation of Interleukin 6 by Histone Acetylation in Macrophages and Its Role in Paraquat-Induced Pulmonary Fibrosis. Paraquat 93-101 interleukin 6 Homo sapiens 25-38 26905270-3 2016 Interleukin-6 levels were lower with higher 25-hydroxyvitamin D. 25-hydroxyvitamin D 44-63 interleukin 6 Homo sapiens 0-13 27000882-3 2016 HUVECs were pretreated with kaempferol (0, 1, 3, or 10 muM) for 1 h and exposed to aldosterone (10(-6) M) for 24 h. Kaempferol reduced ROS, OPN, NF-kappaB, IL-6, and TNF-alpha levels; Nox4, alphavbeta3 integrin; and P-IkappaBalpha expressions. kaempferol 116-126 interleukin 6 Homo sapiens 156-160 28194150-6 2016 In PQ-treated lungs and macrophages, we found that the mRNA and protein expression of IL-6 was robustly increased in a time-dependent and a dose-dependent manner. Paraquat 3-5 interleukin 6 Homo sapiens 86-90 28194150-7 2016 Our data demonstrated that PQ-induced IL-6 expression in macrophages plays a central role in pulmonary fibrosis through enhanced epithelial-to-mesenchymal transition (EMT). Paraquat 27-29 interleukin 6 Homo sapiens 38-42 28194150-8 2016 IL-6 expression and its role to enhance PQ-induced pulmonary fibrosis were increased by histone deacetylase (HDAC) inhibition and prevented by histone acetyltransferase (HAT) inhibition. Paraquat 40-42 interleukin 6 Homo sapiens 0-4 28194150-11 2016 In conclusion, IL-6 functioning through EMT in PQ-induced pulmonary fibrosis was regulated dynamically by HDAC and HAT both in vitro and in vivo via epigenetically regulating chromatin accessibility. Paraquat 47-49 interleukin 6 Homo sapiens 15-19 26658749-8 2016 Citral decreased the levels of WBCs and inflammatory cytokines TNF-alpha and IL-6. citral 0-6 interleukin 6 Homo sapiens 77-81 35612681-0 2022 Regulation of interleukin-6 and matrix metalloproteinases syntheses by bioflavonoids and photobiomodulation in human gingival fibroblasts. Flavonoids 71-84 interleukin 6 Homo sapiens 14-27 28099578-8 2017 In the GAgP group, IL-6 GG genotype and G allele frequency were higher than in the control group. gagp 7-11 interleukin 6 Homo sapiens 19-23 35578571-11 2022 In PDAC patients, the high-N-inv group showed poor prognosis (p =0.059) and elevated serum levels of IL-6 and C-reactive protein, synthesis of which is promoted by IL-6, compared to those in the low-N-inv group (p = 0.006 and p = 0.075, respectively). n-inv 27-32 interleukin 6 Homo sapiens 101-105 27903743-6 2017 We found that uric acid (monosodium urate [MSU]) crystals induce a proinflammatory profile in isolated human term cytotrophoblast cells, with a predominant secretion of IL-1beta and IL-6, a result confirmed in human term placental explants. Uric Acid 14-23 interleukin 6 Homo sapiens 182-186 26334623-7 2016 Upon MC-A treatment, hMSCs decreased the expression levels of various cytokines including TNF-alpha, VEGF, IL-6, IL-8 and FGF-2. myrtucommulone A 5-9 interleukin 6 Homo sapiens 107-111 35578571-11 2022 In PDAC patients, the high-N-inv group showed poor prognosis (p =0.059) and elevated serum levels of IL-6 and C-reactive protein, synthesis of which is promoted by IL-6, compared to those in the low-N-inv group (p = 0.006 and p = 0.075, respectively). n-inv 27-32 interleukin 6 Homo sapiens 164-168 26884290-7 2016 In turn, the effect of fenofibrate, alone or in combination with simvastatin, on TNF-alpha, interleukin-6, and hsCRP, but not on interleukin-1beta and MCP-1, was stronger in patients aged between 50 and 75 years, and correlated with an improvement in insulin sensitivity only in this age group. Simvastatin 65-76 interleukin 6 Homo sapiens 92-105 27903743-6 2017 We found that uric acid (monosodium urate [MSU]) crystals induce a proinflammatory profile in isolated human term cytotrophoblast cells, with a predominant secretion of IL-1beta and IL-6, a result confirmed in human term placental explants. Uric Acid 25-41 interleukin 6 Homo sapiens 182-186 27903743-6 2017 We found that uric acid (monosodium urate [MSU]) crystals induce a proinflammatory profile in isolated human term cytotrophoblast cells, with a predominant secretion of IL-1beta and IL-6, a result confirmed in human term placental explants. Uric Acid 43-46 interleukin 6 Homo sapiens 182-186 28116315-0 2016 LPS Cooperates with Poly-L-Arginine to Promote IL-6 and IL-8 Release via the JNK Signaling Pathway in NCI-H292 Cells. polyarginine 20-35 interleukin 6 Homo sapiens 47-51 35578571-14 2022 This study is the first evidence that the IL-6/gp130 axis offers a potential therapeutic target in PDAC with N-inv. n-inv 109-114 interleukin 6 Homo sapiens 42-46 28116315-2 2016 Herein, we aimed to study the mechanism whereby poly-L-arginine (PLA) and lipopolysaccharide (LPS) can synergistically induce the release of interleukin-6 (IL-6) and IL-8 in NCI-H292 cells. polyarginine 48-63 interleukin 6 Homo sapiens 141-154 35592412-11 2022 The mRNA and protein expression levels of Interleukin-6 (IL-6) and Tumor necrosis factor-alpha (TNF-alpha) were decreased after treatment with DHA. dihydroarteannuin 143-146 interleukin 6 Homo sapiens 42-55 28116315-2 2016 Herein, we aimed to study the mechanism whereby poly-L-arginine (PLA) and lipopolysaccharide (LPS) can synergistically induce the release of interleukin-6 (IL-6) and IL-8 in NCI-H292 cells. polyarginine 48-63 interleukin 6 Homo sapiens 156-160 28116315-2 2016 Herein, we aimed to study the mechanism whereby poly-L-arginine (PLA) and lipopolysaccharide (LPS) can synergistically induce the release of interleukin-6 (IL-6) and IL-8 in NCI-H292 cells. polyarginine 65-68 interleukin 6 Homo sapiens 141-154 28116315-2 2016 Herein, we aimed to study the mechanism whereby poly-L-arginine (PLA) and lipopolysaccharide (LPS) can synergistically induce the release of interleukin-6 (IL-6) and IL-8 in NCI-H292 cells. polyarginine 65-68 interleukin 6 Homo sapiens 156-160 28033321-0 2016 Atorvastatin, Losartan and Captopril Lead to Upregulation of TGF-beta, and Downregulation of IL-6 in Coronary Artery Disease and Hypertension. Captopril 27-36 interleukin 6 Homo sapiens 93-97 28033321-10 2016 DISCUSSION: According to the results it seems that Atorvastatin, Losartan and Captopril have reduced inflammation in in vivo conditions via downregulation of IL-6 and upregulation of TGF-beta. Captopril 78-87 interleukin 6 Homo sapiens 158-162 28078022-8 2016 The impact of miR-19 on the expression of TLR2, interleukin 6 (IL-6), and matrix metalloproteinase 3 (MMP-3) in FLS were analyzed by cell transfection and Western blot. mir-19 14-20 interleukin 6 Homo sapiens 48-61 28078022-8 2016 The impact of miR-19 on the expression of TLR2, interleukin 6 (IL-6), and matrix metalloproteinase 3 (MMP-3) in FLS were analyzed by cell transfection and Western blot. mir-19 14-20 interleukin 6 Homo sapiens 63-67 27994266-8 2016 In both RA and OA patient groups, stimulation of SAAT explants with IL-1beta (1 ng/ml/100 mg tissue) significantly up-regulated release of pro-(IL-6, IL-8, tumor necrosis factor - TNF) and anti-inflammatory (IL-10) cytokines but had no effect on the secretion of adiponectin, leptin, MIF and hepatocyte growth factor (HGF). saat 49-53 interleukin 6 Homo sapiens 144-148 28078022-11 2016 Transfection of miR-19 mimic or miR-19 inhibitor obviously suppressed or increased TLR2 expression, and reduced or promoted release of cytokines IL-6 and MMP-3 in FLS, respectively. mir-19 16-22 interleukin 6 Homo sapiens 145-149 35592412-11 2022 The mRNA and protein expression levels of Interleukin-6 (IL-6) and Tumor necrosis factor-alpha (TNF-alpha) were decreased after treatment with DHA. dihydroarteannuin 143-146 interleukin 6 Homo sapiens 57-61 28078022-11 2016 Transfection of miR-19 mimic or miR-19 inhibitor obviously suppressed or increased TLR2 expression, and reduced or promoted release of cytokines IL-6 and MMP-3 in FLS, respectively. mir-19 32-38 interleukin 6 Homo sapiens 145-149 35559267-11 2022 These results indicate that THF can effectively decrease neural cell apoptosis through the caspase-3 pathway and restrain excessive abnormal activation of astrocytes and the release of TNF-alpha and IL-6, which might be accompanied by the recovery of motor function. tetrahydrofuran 28-31 interleukin 6 Homo sapiens 199-203 27411707-7 2016 Interestingly, although very high concentrations (25-50 microM) of Simvastatin resulted in dramatically less IL-6 and IL-8 pro-inflammatory cytokine secretion, 2.5 microM Simvastatin did not reduce the total amount of pro-inflammatory cytokines secreted during mechanical stimulation. Simvastatin 67-78 interleukin 6 Homo sapiens 109-113 27074340-0 2016 IL-6 and IL-10 levels in the umbilical cord blood of newborns with a history of crack/cocaine exposure in utero: a comparative study. Cocaine 86-93 interleukin 6 Homo sapiens 0-4 27449264-9 2016 Treatment with PI3K inhibitor ZSTK474 or STAT3 inhibitor niclosamide reversed the effects of WSTF overexpression by inhibiting cell proliferation, migration and invasion, with decreased level of p-Akt, p-STAT3 and IL-6. ZSTK474 30-37 interleukin 6 Homo sapiens 214-218 35059921-9 2022 After treatment with TAL-6, the serum levels of TNF-alpha, IL-1beta, and IL-6 were significantly decreased, and sepsis-induced pathological injuries in the kidney were remarkably attenuated. tal-6 21-26 interleukin 6 Homo sapiens 73-77 27576059-3 2016 In our study, we studied the effects of daidzein, raloxifene and E2 on expression of the osteoblast-produced bone regulatory factors OPG, RANKL and IL-6 in human osteoblastic MG-63 cells. daidzein 40-48 interleukin 6 Homo sapiens 148-152 27576059-4 2016 Results suggest that treatment with daidzein, raloxifene and E2 increased the levels of OPG and decreased those of RANKL and IL-6. daidzein 36-44 interleukin 6 Homo sapiens 125-129 27012464-9 2016 MPAID also inhibited TNF-alpha-induced NF-kappaB transcriptional activity, the mRNA expression of IL-6 and IL-8, and IL-6 production. mpaid 0-5 interleukin 6 Homo sapiens 98-102 26395918-5 2015 Furthermore, fucosterol attenuated CoCl2 induced excess expression of IL-6, IL-1beta and TNF-alpha in HaCaT cells. cobaltous chloride 35-40 interleukin 6 Homo sapiens 70-74 25715004-5 2015 RESULTS: Latanoprost stimulated the release of IL-6, IL-8, and MCP-1 from HTFs in a concentration-dependent and time-dependent manner, whereas timolol maleate and pilocarpine had no such effects. Latanoprost 9-20 interleukin 6 Homo sapiens 47-51 35014767-4 2022 In human MM cell lines, mycolactone caused rapid defects in secretion of immunoglobulins and expression of pro-survival interleukin (IL)-6 receptor and CD40, whose activation stimulates IL-6 production. mycolactone 24-35 interleukin 6 Homo sapiens 186-190 26402162-10 2015 Selenite decreases the IL6-induced ROS and carbonyl content, while enhances Gpx and Trx activities. Selenious Acid 0-8 interleukin 6 Homo sapiens 23-26 25847254-3 2015 We found that 10-MDP caused the release of inflammatory cytokines including NO, PGE2, iNOS, COX-2, TNF-alpha, IL-1beta, IL-6 and IL-8 in a concentration-dependent manner. methacryloyloxydecyl dihydrogen phosphate 14-20 interleukin 6 Homo sapiens 120-124 27012464-9 2016 MPAID also inhibited TNF-alpha-induced NF-kappaB transcriptional activity, the mRNA expression of IL-6 and IL-8, and IL-6 production. mpaid 0-5 interleukin 6 Homo sapiens 117-121 27309886-0 2016 Effect of intravenous lidocaine combined with amitriptyline on pain intensity, clinical manifestations and the concentrations of IL-1, IL-6 and IL-8 in patients with fibromyalgia: A randomized double-blind study. Lidocaine 22-31 interleukin 6 Homo sapiens 135-139 35309531-7 2022 After HIIT, IL-6 deceased (p < 0.001) in EG100 (d = 1.43) and EG110 (d = 1.56) at rest, at the end of HIIE (d = 1.03; d = 1.75, respectively) and at 15 min of recovery (d = 0.88;d = 1.7, respectively). eg100 41-46 interleukin 6 Homo sapiens 12-16 27357856-7 2016 Negative correlations were observed between serum 25OHD and TNFalpha, IL-1beta or IL-6 levels in healthy subjects or MCI patients, but these same correlations were positive in LOAD patients. 25ohd 50-55 interleukin 6 Homo sapiens 82-86 26445366-3 2015 Here we showed that lidocaine inhibited the production of IL-6, TNFalpha and IL-12 from dendritic cells in response to toll-like receptor ligands including lipopolysaccharide, poly(I:C) and R837 in a dose-dependent manner. Lidocaine 20-29 interleukin 6 Homo sapiens 58-62 35365985-4 2022 The bisulfate sequencing PCR(BSP)was used to analyze the cytosine methylation in the IL-6 promoter region of each group. Cytosine 57-65 interleukin 6 Homo sapiens 85-89 25730740-6 2015 The LAP-IPAA group had significantly lower interleukin-6 and interleukin-1ra levels soon after surgery (P=0.011 and P=0.0076). ipaa 8-12 interleukin 6 Homo sapiens 43-56 27681882-14 2016 Importantly, nicotine"s inhibitory effect on IL-6 production was reversed with the specific COX-2 inhibitor NS-398. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 108-114 interleukin 6 Homo sapiens 45-49 35237386-11 2022 The cutoff value of IL-6 for in-hospital death prediction was 74.98 pg/mL (Sn 69.7%, Sp 62.7%); cutoff value of CRP was 81 mg/L (Sn 60.7%, Sp 60%); cutoff value of procalcitonin was 0.56 ng/mL (Sn 81.1%, Sp 76%); and cutoff value of D-dimer was 760 ng/mL FEU (Sn 63.4%, Sp 57.1%). Tin 75-77 interleukin 6 Homo sapiens 20-24 27650878-11 2016 Atorvastatin and simvastatin suppressed the DC maturation showing lower expression of CD80, CD83, and CD86, and limited their production of tumor necrosis factor-alpha, IL-1beta and IL-6, and increased transforming growth factor-beta and IL-10 secretion. Simvastatin 17-28 interleukin 6 Homo sapiens 182-186 27488030-7 2016 Moreover, 10 and 20 muM DCVC increased mRNA expression and release of interleukin-6 (IL-6) after 24-h exposure, and these responses were inhibited by the cysteine conjugate beta-lyase inhibitor aminooxyacetic acid and by treatments with antioxidants (alpha-tocopherol and deferoxamine), suggesting that DCVC-stimulated IL-6 release in HTR-8/SVneo cells is dependent on beta-lyase metabolic activation and increased generation of ROS. alpha-Tocopherol 251-267 interleukin 6 Homo sapiens 85-89 26142696-4 2015 The data provided in this study suggest that PFOS and PFOA can have cytotoxic potential and modulate processes associated with intestinal inflammation such as myofibroblasts proliferation and IL-6 production at concentrations similar to those detected in vivo. perfluorooctane sulfonic acid 45-49 interleukin 6 Homo sapiens 192-196 26142696-4 2015 The data provided in this study suggest that PFOS and PFOA can have cytotoxic potential and modulate processes associated with intestinal inflammation such as myofibroblasts proliferation and IL-6 production at concentrations similar to those detected in vivo. perfluorooctanoic acid 54-58 interleukin 6 Homo sapiens 192-196 35237386-11 2022 The cutoff value of IL-6 for in-hospital death prediction was 74.98 pg/mL (Sn 69.7%, Sp 62.7%); cutoff value of CRP was 81 mg/L (Sn 60.7%, Sp 60%); cutoff value of procalcitonin was 0.56 ng/mL (Sn 81.1%, Sp 76%); and cutoff value of D-dimer was 760 ng/mL FEU (Sn 63.4%, Sp 57.1%). Tin 194-196 interleukin 6 Homo sapiens 20-24 35237386-11 2022 The cutoff value of IL-6 for in-hospital death prediction was 74.98 pg/mL (Sn 69.7%, Sp 62.7%); cutoff value of CRP was 81 mg/L (Sn 60.7%, Sp 60%); cutoff value of procalcitonin was 0.56 ng/mL (Sn 81.1%, Sp 76%); and cutoff value of D-dimer was 760 ng/mL FEU (Sn 63.4%, Sp 57.1%). Tin 260-262 interleukin 6 Homo sapiens 20-24 27379793-1 2016 PURPOSE: This investigation examined if a high carbohydrate (CHO) diet, maintained across a seven-day training period, could attenuate post-exercise interleukin-6 (IL-6) and serum hepcidin levels. CAV protocol 61-64 interleukin 6 Homo sapiens 149-162 35197546-9 2022 Taken together, we conclude that Laminin alpha5/FAK signaling is responsible for IL-6-induced osimertinib resistance, which could be reversed by combination of ibrutinib and osimertinib. osimertinib 174-185 interleukin 6 Homo sapiens 81-85 27379793-1 2016 PURPOSE: This investigation examined if a high carbohydrate (CHO) diet, maintained across a seven-day training period, could attenuate post-exercise interleukin-6 (IL-6) and serum hepcidin levels. CAV protocol 61-64 interleukin 6 Homo sapiens 164-168 26406906-9 2015 The pretreatment of blood immune cells with EPs 7630 lowered their secretion of TNF-alpha and IL-10 and caused an IL-6 dominant response during second stimulation with viral or bacterial infection-mimicking agents. exophthalmos producing substance 44-47 interleukin 6 Homo sapiens 114-118 35250984-9 2022 Lung hypercellularity and infiltration of macrophages and CD4+ T-cells were dramatically decreased in PT150-treated animals, as was tissue damage and expression of IL-6. Org34517 102-107 interleukin 6 Homo sapiens 164-168 27297769-0 2016 Plasma interleukin-6 and executive function in crack cocaine-dependent women. Cocaine 53-60 interleukin 6 Homo sapiens 7-20 27297769-1 2016 AIM: The aim of this study was to investigate the association between plasma interleukin 6 (IL-6) levels and executive function (EF) in crack cocaine-dependent women. Cocaine 142-149 interleukin 6 Homo sapiens 77-90 27297769-1 2016 AIM: The aim of this study was to investigate the association between plasma interleukin 6 (IL-6) levels and executive function (EF) in crack cocaine-dependent women. Cocaine 142-149 interleukin 6 Homo sapiens 92-96 27297769-4 2016 RESULTS: The CRACK group had poor performance on WSCT scores (Non-perseverative Errors and Percent Conceptual Level Responses) and higher plasma IL-6 levels when compared with the CONTROL group. Cocaine 13-18 interleukin 6 Homo sapiens 145-149 27297769-5 2016 Furthermore, IL-6 was correlated with worsening of several WCST sub-scores and a linear regression model showed that IL-6 levels predicted worse cognitive flexibility within the CRACK group independently of intelligence quotient and education. Cocaine 178-183 interleukin 6 Homo sapiens 117-121 27297769-6 2016 CONCLUSIONS: The results of this study indicated that low performances in EF task are associated with higher IL-6 levels in crack cocaine-dependent women. Cocaine 130-137 interleukin 6 Homo sapiens 109-113 26101800-0 2015 The IL-6/STAT3 pathway via miR-21 is involved in the neoplastic and metastatic properties of arsenite-transformed human keratinocytes. arsenite 93-101 interleukin 6 Homo sapiens 4-8 26101800-4 2015 In HaCaT cells, arsenite caused increases of IL-6 and miR-21 levels and activation of STAT3, which induced the epithelial-mesenchymal transition (EMT). arsenite 16-24 interleukin 6 Homo sapiens 45-49 26101800-7 2015 In arsenite-transformed HaCaT (HaCaT-30T) cells, down-regulation of STAT3 by siRNA blocked the process of EMT and decreased their neoplastic properties and migratory capacity, effects that were antagonized by over-expression of miR-21.Thus, the IL-6/STAT3 pathway via miR-21 is involved in EMT, neoplastic properties, and migratory capacity of arsenite-transformed HaCaT cells. arsenite 3-11 interleukin 6 Homo sapiens 245-249 35115578-10 2022 The dimensions of response to the exercises observed through the changes in the concentration of 25(OH)D3, PTH, NEFA and glycerol were associated with the significant increases of IL-6 level. Fatty Acids, Nonesterified 112-116 interleukin 6 Homo sapiens 180-184 26340264-7 2015 The adipose tissue and placenta of treated women exhibited a significant decrease in TLR4 adipose and placental expression as well as IL6, IL8, and TNFalpha In vitro, EPA and DHA suppressed the activation of TLR4, IL6, IL8 induced by palmitate in culture of adipose and trophoblast cells. Eicosapentaenoic Acid 167-170 interleukin 6 Homo sapiens 134-137 26340264-7 2015 The adipose tissue and placenta of treated women exhibited a significant decrease in TLR4 adipose and placental expression as well as IL6, IL8, and TNFalpha In vitro, EPA and DHA suppressed the activation of TLR4, IL6, IL8 induced by palmitate in culture of adipose and trophoblast cells. Eicosapentaenoic Acid 167-170 interleukin 6 Homo sapiens 214-217 26690867-0 2015 Doxorubicin-Hyaluronan Conjugated Super-Paramagnetic Iron Oxide Nanoparticles (DOX-HA-SPION) Enhanced Cytoplasmic Uptake of Doxorubicin and Modulated Apoptosis, IL-6 Release and NF-kappaB Activity in Human MDA-MB-231 Breast Cancer Cells. Hyaluronic Acid 12-22 interleukin 6 Homo sapiens 161-165 27145783-4 2016 AOPP-FR and AOPP-HOCl were able to induce the activation of the gene transcription of NF-kappaB, COX-2, and IL-6 in HEK 293 cells. aopp-hocl 12-21 interleukin 6 Homo sapiens 108-112 27145783-5 2016 However, the effects of AOPP-FR were significantly higher than the effects of AOPP-HOCl in relation to COX-2 and IL-6. aopp-hocl 78-87 interleukin 6 Homo sapiens 113-117 35115578-10 2022 The dimensions of response to the exercises observed through the changes in the concentration of 25(OH)D3, PTH, NEFA and glycerol were associated with the significant increases of IL-6 level. Glycerol 121-129 interleukin 6 Homo sapiens 180-184 27288094-5 2016 Furthermore, PFOS inhibited the reduction of IL-6 and IL-1beta, the key proinflammatory cytokines in maternal-fetal immune intolerance, by cortisone in the decidual stromal cells indicating attenuated conversion of cortisone to cortisol. perfluorooctane sulfonic acid 13-17 interleukin 6 Homo sapiens 45-49 35109870-10 2022 Both Pam3C and LPS were more able to elevate the frequency of IL-6+CD4+T cells and Th17.1 cells in CCMSympt cell cultures. pam3c 5-10 interleukin 6 Homo sapiens 62-66 27288094-5 2016 Furthermore, PFOS inhibited the reduction of IL-6 and IL-1beta, the key proinflammatory cytokines in maternal-fetal immune intolerance, by cortisone in the decidual stromal cells indicating attenuated conversion of cortisone to cortisol. Cortisone 139-148 interleukin 6 Homo sapiens 45-49 27221654-2 2016 Donor interleukin-6 (IL-6) rs1800796 single nucleotide polymorphisms (SNPs) affect the metabolism of tacrolimus following liver transplantation-related hepatic H/R. Tacrolimus 101-111 interleukin 6 Homo sapiens 6-19 25987541-10 2015 IL-1beta-increased IL-6 release was reduced with cytochalasin B, epalrestat, L-NAME or MitoTEMPO treatment (-45%, -62%, -38% and -40%, respectively). Cytochalasin B 49-63 interleukin 6 Homo sapiens 19-23 26170625-8 2015 RESULTS: In the experimental group, vitamin C significantly reduced the levels of high-sensitivity C-reactive protein (hs-CRP), interleukin 6 (IL-6), fasting blood glucose (FBG), and triglyceride (TG) after 8 weeks of treatment (overall: P<0.001); no changes appeared in total cholesterol (TC). Ascorbic Acid 36-45 interleukin 6 Homo sapiens 128-141 27221654-2 2016 Donor interleukin-6 (IL-6) rs1800796 single nucleotide polymorphisms (SNPs) affect the metabolism of tacrolimus following liver transplantation-related hepatic H/R. Tacrolimus 101-111 interleukin 6 Homo sapiens 21-25 26170625-8 2015 RESULTS: In the experimental group, vitamin C significantly reduced the levels of high-sensitivity C-reactive protein (hs-CRP), interleukin 6 (IL-6), fasting blood glucose (FBG), and triglyceride (TG) after 8 weeks of treatment (overall: P<0.001); no changes appeared in total cholesterol (TC). Ascorbic Acid 36-45 interleukin 6 Homo sapiens 143-147 35059772-8 2022 RESULTS: In the present study, we found that DHA significantly suppressed AngII-induced proliferation of VSMCs and the expression of IL-6 and Ccl2 in a dose-dependent manner. artenimol 45-48 interleukin 6 Homo sapiens 133-137 26170625-10 2015 On comparing the changes in the experimental group with those in the control group at the endpoint, vitamin C was found to have achieved clinical significance in treating effectiveness for reducing hs-CRP, IL-6, and FBG levels (P=0.01, P=0.001, and P<0.001, respectively), but no significant changes in TC or TG were found. Ascorbic Acid 100-109 interleukin 6 Homo sapiens 206-210 26988732-11 2016 Gene expression correlated directly with serum bilirubin and INR (r=0.79; p<0.001 and r=0.67; p<0.001), MELD (r=0.68; p<0.001) and Interleukin-6 (r=0.65; p<0.001). Bilirubin 47-56 interleukin 6 Homo sapiens 140-153 35126375-6 2021 Moreover, HZ-0408b showed a more potent inhibitory effect on IL-6 signaling than Siltuximab, an FDA-approved anti-IL-6 chimeric mAb. hz-0408b 10-18 interleukin 6 Homo sapiens 61-65 27045865-14 2016 CONCLUSIONS: Berberine, baicalin and geniposide could neutralize LPS by binding with lipid A and then reduce the release of IL-6 and TNF-alpha induced by LPS. baicalin 24-32 interleukin 6 Homo sapiens 124-128 26653645-14 2015 Compared with the blank control group, the PQ group had significantly increased IL-6 and TNF-alpha level (P < 0.05); Compared with the PQ group, the UTI+PQ group had significantly decreased IL-6 and TNF-alpha level (P < 0.05). Paraquat 43-45 interleukin 6 Homo sapiens 80-84 26653645-14 2015 Compared with the blank control group, the PQ group had significantly increased IL-6 and TNF-alpha level (P < 0.05); Compared with the PQ group, the UTI+PQ group had significantly decreased IL-6 and TNF-alpha level (P < 0.05). Paraquat 43-45 interleukin 6 Homo sapiens 193-197 27278808-15 2016 CONCLUSIONS: Pulmonary exposure to ZnO-coated MWCNTs produces a systemic acute phase response that involves the release of Zn(+2), lung epithelial growth arrest, and increased IL-6. mwcnts 46-52 interleukin 6 Homo sapiens 176-180 25852008-7 2015 The intracellular calcium chelator BAPTA-AM blunted l-C16 carnitine-mediated IL-6 production by >65%. 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 35-43 interleukin 6 Homo sapiens 77-81 35095870-5 2021 Additionally, the psilacetin was found to inhibit human interleukin-6 receptors to reduce cytokine storm. 4-acetoxy-dimethyltryptamine 18-28 interleukin 6 Homo sapiens 56-69 25639473-10 2015 Additionally, salidroside significantly attenuated UVB-induced synthesis of MMP-1 as well as the production of IL-6 and TNF-alpha in HDFs. rhodioloside 14-25 interleukin 6 Homo sapiens 111-115 27079270-4 2016 Although previous studies reported anti-inflammatory properties of Oligonol, it is unknown whether and how Oligonol suppresses IL-6 and TNF-alpha production in human monocytes. oligonol 107-115 interleukin 6 Homo sapiens 127-131 27079270-5 2016 The results of our study demonstrate that Oligonol (25mug/ml) decreases the production of IL-6 and TNF-alpha from human primary monocytes as measured by flow cytometry and ELISA. oligonol 42-50 interleukin 6 Homo sapiens 90-94 35095870-6 2021 The binding of psilacetin to Mprotease of SARS-CoV-2 and human interleukin-6 receptors changes the structural dynamics and Gibbs free energy patterns of proteins. 4-acetoxy-dimethyltryptamine 15-25 interleukin 6 Homo sapiens 63-76 34994311-0 2022 The role of flavonoids in inhibiting IL-6 and inflammatory arthritis. Flavonoids 12-22 interleukin 6 Homo sapiens 37-41 27227519-8 2016 Multiple logistic regression analysis showed that the CRP>=16.5mg/L, LDH >=417IU/L and IL-6 >=14.75pg/ml were significant predictors regarding to RMPP. rmpp 155-159 interleukin 6 Homo sapiens 93-97 27227519-9 2016 CONCLUSIONS: CRP>=16.5mg/L, LDH >=417IU/L and IL-6 >=14.75pg/ml might be the significant predictors of RMPP in children, which can aid in early recognition of RMPP. rmpp 112-116 interleukin 6 Homo sapiens 52-56 27227519-9 2016 CONCLUSIONS: CRP>=16.5mg/L, LDH >=417IU/L and IL-6 >=14.75pg/ml might be the significant predictors of RMPP in children, which can aid in early recognition of RMPP. rmpp 168-172 interleukin 6 Homo sapiens 52-56 26020773-7 2015 The production of IL-6, IL-8 and MMP-3 by chondrocytes significantly decreased in chitosan-alginate beads compared to alginate beads. Chitosan 82-90 interleukin 6 Homo sapiens 18-22 25843793-7 2015 Propranolol and DPI [NAD(P)H oxidase inhibitor] decreased NE-stimulated reactive oxygen species (ROS) generation, and antioxidant NAC completely abolished NE-induced IL-6 expression in U937 macrophages. 3-aminodiphenyleneiodium 16-19 interleukin 6 Homo sapiens 166-170 25843793-8 2015 The further study indicated that NAD(P)H oxidase inhibitor DPI and NF-kappaB inhibitor PDTC reduced NE-induced mRNA and protein expression of IL-6 in U937 macrophages. 3-aminodiphenyleneiodium 59-62 interleukin 6 Homo sapiens 142-146 34994311-7 2022 This review thoroughly discusses the accumulate data on the role of flavonoids on IL-6 in RA. Flavonoids 68-78 interleukin 6 Homo sapiens 82-86 26960744-7 2016 Along with the lower levels of inflammatory cytokine gene expressions in the extract, treatment of the 2D IHOKs with Zn(2+) alone and treatment of the 3D IHOKs with Zn(2+) plus eugenol resulted in significantly lower expression levels of IL-1beta, IL-6, and IL-8 (P<0.05). Eugenol 177-184 interleukin 6 Homo sapiens 248-252 2554932-3 1989 In this study, we demonstrated that monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals, and to a lesser extent, hydroxyapatite crystals, increased IL-6 production by synoviocytes and monocytes in vitro. Uric Acid 36-52 interleukin 6 Homo sapiens 171-175 27195204-0 2016 Effect of topical simvastatin (1.2 mg) on gingival crevicular fluid interleukin-6, interleukin-8 and interleukin-10 levels in chronic periodontitis - A clinicobiochemical study. Simvastatin 18-29 interleukin 6 Homo sapiens 68-81 27195204-7 2016 RESULTS: SMV has an inhibitory effect on pro-inflammatory cytokines (IL-6, IL-8) and stimulatory effect on anti-inflammatory cytokines (IL-10) in GCF of periodontitis patients and has significantly positive effect on all clinical parameters except relative attachment level (RAL). Simvastatin 9-12 interleukin 6 Homo sapiens 69-73 26700310-7 2016 In contrast, without IL-6 coculture, enhanced HO-1 expression in U266, RPMI8226 and bone marrow CD138(+) cells from MM patients significantly inreased IL-6 mRNA expression levels and facilitated autocrine IL-6 production. rpmi8226 71-79 interleukin 6 Homo sapiens 151-155 26700310-7 2016 In contrast, without IL-6 coculture, enhanced HO-1 expression in U266, RPMI8226 and bone marrow CD138(+) cells from MM patients significantly inreased IL-6 mRNA expression levels and facilitated autocrine IL-6 production. rpmi8226 71-79 interleukin 6 Homo sapiens 151-155 26923510-11 2016 IL-6 was a significant mediator of the association between fruits with low carotenoid content and depression in women. Carotenoids 75-85 interleukin 6 Homo sapiens 0-4 26901838-6 2016 Daidzein significantly decreased chemokine (C-C motif) ligand 2 (Ccl2, known in humans as monocyte chemo-attractant protein 1 (MCP1)) and interleukin 6 (Il6) mRNA levels induced by co-culture. daidzein 0-8 interleukin 6 Homo sapiens 138-151 26901838-6 2016 Daidzein significantly decreased chemokine (C-C motif) ligand 2 (Ccl2, known in humans as monocyte chemo-attractant protein 1 (MCP1)) and interleukin 6 (Il6) mRNA levels induced by co-culture. daidzein 0-8 interleukin 6 Homo sapiens 153-156 26901838-8 2016 Daidzein also decreased Ccl2 and Il6 mRNA levels in RAW264 macrophages stimulated with palmitate or conditioned medium (CM) from hypertrophied 3T3-L1 adipocytes. daidzein 0-8 interleukin 6 Homo sapiens 33-36 26515034-7 2016 RESULTS: The GABR value was (i) significantly lower in PTSD subjects compared to controls (p=0.001), (ii) significantly inversely correlated with markers of inflammation including IL6 (p=0.04) and TNFalpha (p=0.02), and (iii) significantly inversely correlated with CAPS current (p=0.001) and lifetime (p<0.001) subscales, ETI (p=0.045) and PANAS negative (p=0.006). gabr 13-17 interleukin 6 Homo sapiens 180-183 27057094-3 2016 The results indicated that GEN-27 inhibited the proliferation of human colon tumor HCT116 cells stimulated by culture supernatants of LPS-induced human monocytes THP-1 cells and significantly decreased LPS-induced secretion of proinflammatory cytokines interleukin-6 and interleukin-1beta in THP-1 cells. gen-27 27-33 interleukin 6 Homo sapiens 253-266 26678745-6 2015 The results revealed that acarbose at the dose of 500 mg/kg/day attenuated the incidence and severity of arthritis and the expression of proinflammatory cytokines, including TNF-alpha, IL-6 and IL-17 in the paw tissues. Acarbose 26-34 interleukin 6 Homo sapiens 185-189 26084452-7 2015 In addition, vicenin-2 or scolymoside suppressed the production of tumor necrosis factor-alpha and interleukin 6 and activation of nuclear factor-kappaB and extracellular regulated kinases 1/2 by TGFBIp. scolymoside 26-37 interleukin 6 Homo sapiens 99-192 26251510-9 2015 beta-CTX, P1NP, and IL-6 responses to exercise were significantly lower in the immediate postexercise period with CHO feeding compared with PBO (beta-CTX: P = 0.028; P1NP: P = 0.021; IL-6: P = 0.036), although there was no difference in the short-term response (beta-CTX: P = 0.856; P1NP: P = 0.721; IL-6: P = 0.327). CAV protocol 114-117 interleukin 6 Homo sapiens 20-24 26251510-9 2015 beta-CTX, P1NP, and IL-6 responses to exercise were significantly lower in the immediate postexercise period with CHO feeding compared with PBO (beta-CTX: P = 0.028; P1NP: P = 0.021; IL-6: P = 0.036), although there was no difference in the short-term response (beta-CTX: P = 0.856; P1NP: P = 0.721; IL-6: P = 0.327). CAV protocol 114-117 interleukin 6 Homo sapiens 183-187 26251510-9 2015 beta-CTX, P1NP, and IL-6 responses to exercise were significantly lower in the immediate postexercise period with CHO feeding compared with PBO (beta-CTX: P = 0.028; P1NP: P = 0.021; IL-6: P = 0.036), although there was no difference in the short-term response (beta-CTX: P = 0.856; P1NP: P = 0.721; IL-6: P = 0.327). CAV protocol 114-117 interleukin 6 Homo sapiens 183-187 26758116-13 2015 (2) Incresed BALF IL-1 beta, IL-4, IL-6, IL-8, IL-10, IFN-gamma levels were observed in RMPP and high level of BALF IL-2 and IL-8 might have some relevance with persistent fever of RMPP in children. rmpp 88-92 interleukin 6 Homo sapiens 35-39 26550333-3 2015 The changes of plasma interleukin-6 (IL-6) induced by simvastatin in patients with sepsis and severe sepsis were similar with that of TLR4. Simvastatin 54-65 interleukin 6 Homo sapiens 22-35 26550333-3 2015 The changes of plasma interleukin-6 (IL-6) induced by simvastatin in patients with sepsis and severe sepsis were similar with that of TLR4. Simvastatin 54-65 interleukin 6 Homo sapiens 37-41 25822580-4 2015 Co-stimulation with IFN-gamma and the TLR3 ligand poly (I:C) synergistically increased the expression of IFN-beta, IL-6, IL-8, and human beta-defensin-2 in NHEKs compared with poly (I:C) or IFN-gamma alone. Iodine 20-21 interleukin 6 Homo sapiens 115-119 25631486-9 2015 CONCLUSIONS: The elevated levels of MCP-1 and IL-6 may indicate prolonged inflammation even after successful vitrectomy, which can cause postoperative DME. dme 151-154 interleukin 6 Homo sapiens 46-50 26004152-6 2015 Two inhibitors of NF-kappaB blocked the increased levels of IL-6, TNFalpha, and IL-3 in MeCP2-deficient PBMC treated with lipopolysaccharide. PBMC 104-108 interleukin 6 Homo sapiens 60-64 25818949-0 2015 Hyaluronic acid decreases IL-6 and IL-8 secretion and permeability in an inflammatory model of interstitial cystitis. Hyaluronic Acid 0-15 interleukin 6 Homo sapiens 26-30 25895106-0 2015 Isolation and Characterization of Dammarane-Type Saponins from Gynostemma pentaphyllum and Their Inhibitory Effects on IL-6-Induced STAT3 Activation. dammarane 34-43 interleukin 6 Homo sapiens 119-123 25975969-7 2015 Moreover, lidocaine treatment markedly suppressed the release of IL-6, S100beta, and NSE into the serum at the end of surgery and 3 days after the end of surgery. Lidocaine 10-19 interleukin 6 Homo sapiens 65-69 25680693-7 2015 Cyn also inhibited the production of proinflammatory cytokines such as interleukin 6 and tumor necrosis factor-alpha from UVB-treated keratinocytes. cynaropicrin 0-3 interleukin 6 Homo sapiens 71-116 25575297-6 2015 A selective Ca(2+) chelator, BAPTA-AM, prevented TRP channel agonists-mediated IL-6 and IL-8 induction. 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 29-37 interleukin 6 Homo sapiens 79-83 25780881-0 2015 Evaluation of the Effect of Ascorbic Acid Administration on Gene Expression Level of IL-6 and TNF-alpha Cytokines in Deceased Donors. Ascorbic Acid 28-41 interleukin 6 Homo sapiens 85-89 24815722-11 2015 RESULTS: The secretion of IL-1beta, TNF-alpha and IL-6 by THP-1 cells was greater in the presence of G-alb than in the presence of N-alb. n-alb 131-136 interleukin 6 Homo sapiens 50-54 26016020-2 2015 An increase in the IL-6, IL-8, TNF-alpha and p53 genes expression in the concentration range of silver and titanium dioxide nanoparticles of 10-40 muk g/ml was found. Silver 96-102 interleukin 6 Homo sapiens 19-23 26016020-2 2015 An increase in the IL-6, IL-8, TNF-alpha and p53 genes expression in the concentration range of silver and titanium dioxide nanoparticles of 10-40 muk g/ml was found. titanium dioxide 107-123 interleukin 6 Homo sapiens 19-23 25637769-6 2015 Pre-exposure of PZ-DHA ester was more effective in reducing tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and cyclooxygenase-2 (COX-2) protein levels compared to DHA and nimesulide. pz-dha ester 16-28 interleukin 6 Homo sapiens 101-114 25637769-6 2015 Pre-exposure of PZ-DHA ester was more effective in reducing tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and cyclooxygenase-2 (COX-2) protein levels compared to DHA and nimesulide. pz-dha ester 16-28 interleukin 6 Homo sapiens 116-120 25201048-4 2015 S1P also induced PGE2 and IL-6 secretion which were reduced by the inhibitors of COX-2 (NS-398 and celecoxib). N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 88-94 interleukin 6 Homo sapiens 26-30 25740274-0 2015 [Effect of intraoperative intravenous lidocaine on pain and plasma interleukin-6 in patients undergoing hysterectomy]. Lidocaine 38-47 interleukin 6 Homo sapiens 67-80 25374119-5 2015 The results demonstrated that simvastatin suppressed the increased mRNA expression of monocyte chemoattractant protein-1, tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-6 and the content of reactive oxygen species induced by Ang II in a dose-dependent manner. Simvastatin 30-41 interleukin 6 Homo sapiens 178-182 25596735-3 2015 We found that carnosic acid markedly induced TRAIL-mediated apoptosis in human renal carcinoma (Caki, ACHN, and A498), and human hepatocellular carcinoma (SK-HEP-1), and human breast carcinoma (MDA-MB-231) cells, but not normal cells (TMCK-1 and HSF). salvin 14-27 interleukin 6 Homo sapiens 235-249 25351958-4 2015 Treatment of macrophages with bosutinib or dasatinib elevates the production of IL-10 while suppressing the production of IL-6, IL-12p40 and tumour necrosis factor alpha (TNFalpha) in response to Toll-like receptor (TLR) stimulation. bosutinib 30-39 interleukin 6 Homo sapiens 122-126 25824798-5 2015 HT-29 cells demonstrated significantly increased RIPK1, RIPK3 and MLKL expression in response to cobalt chloride plus z-VAD treatment, which was accompanied by drastically increased IL1alpha and IL6 expression, substantiating the notion that necrosis can induce profound immune reactions. cobaltous chloride 97-112 interleukin 6 Homo sapiens 195-198 26301880-3 2015 RESULTS: Plasma UA levels were inversely associated with urinary levels of the oxidative stress marker F2-isoprostanes and positively correlated to levels of inflammatory markers, such as C-reactive protein and some proinflammatory cytokines (tumor necrosis factor-alpha and interleukin-6) in blood as well as prostaglandin E2 metabolites in urine. Uric Acid 16-18 interleukin 6 Homo sapiens 275-288 25876656-4 2015 Myotubes treated with 1alpha,25(OH)2D3 increased interleukin-6 (IL-6) expression and inhibited expression of tumor necrosis factor alpha (TNF-alpha), whereas the expression of insulin-like growth factor-1 (IGF-1) that is involved in muscle hypertrophy was not affected. 25(oh)2d3 29-38 interleukin 6 Homo sapiens 49-62 25876656-4 2015 Myotubes treated with 1alpha,25(OH)2D3 increased interleukin-6 (IL-6) expression and inhibited expression of tumor necrosis factor alpha (TNF-alpha), whereas the expression of insulin-like growth factor-1 (IGF-1) that is involved in muscle hypertrophy was not affected. 25(oh)2d3 29-38 interleukin 6 Homo sapiens 64-68 25773957-9 2015 Myeloperoxidase, IL-6 and tumour necrosis factor alpha was found to be lower in the candesartan treated groups (p < 0.05). candesartan 84-95 interleukin 6 Homo sapiens 17-54 26279422-8 2015 Treatment with cobalt chloride as an HIF1 activator inhibited IL-6 secretion and TLR4 expression; this effect was reversed on treatment with PX-12 as an HIF1 suppressor. cobaltous chloride 15-30 interleukin 6 Homo sapiens 62-66 26136131-5 2015 Simvastatin, fenofibrate, and simvastatin/fenofibrate combination therapy reduced monocyte release of TNF-alpha, inteleukin-1beta, interleukin-6, and MCP-1, with no difference between the treatment groups. Simvastatin 0-11 interleukin 6 Homo sapiens 131-144 26136131-5 2015 Simvastatin, fenofibrate, and simvastatin/fenofibrate combination therapy reduced monocyte release of TNF-alpha, inteleukin-1beta, interleukin-6, and MCP-1, with no difference between the treatment groups. Simvastatin 30-41 interleukin 6 Homo sapiens 131-144 26136131-7 2015 The effect of simvastatin/fenofibrate combination therapy on monocyte release of interleukin-6 and MCP-1 was more pronounced in the male population. Simvastatin 14-25 interleukin 6 Homo sapiens 81-94 25105909-7 2015 RESULT: In POCD group, the level of IL-6, IL-10, CRP, MMP-9 in serum and uTi /Ucr in urine was significantly higher than that in the group without POCD. pocd 11-15 interleukin 6 Homo sapiens 36-40 25549668-5 2015 In the neuronally derived A1A1 cell line, which expresses both IL-6 and 5-HT2A receptors, we found that IL-6 attenuates inositol phosphate (IP) accumulation in response to the 5-HT2 agonist, 2,5-dimethoxy-4-iodoamphetamine (DOI), suggesting that IL-6 can regulate 5-HT2A receptor function. Inositol Phosphates 120-138 interleukin 6 Homo sapiens 104-108 25549668-5 2015 In the neuronally derived A1A1 cell line, which expresses both IL-6 and 5-HT2A receptors, we found that IL-6 attenuates inositol phosphate (IP) accumulation in response to the 5-HT2 agonist, 2,5-dimethoxy-4-iodoamphetamine (DOI), suggesting that IL-6 can regulate 5-HT2A receptor function. Inositol Phosphates 140-142 interleukin 6 Homo sapiens 104-108 26375619-4 2015 Here, we show that HP-NAP activates human mast cell line-1 (HMC-1) cells to secrete histamine and IL-6. hp-nap 19-25 interleukin 6 Homo sapiens 98-102 26375619-7 2015 Inhibition of ERK1/2, p38 MAPK, or phosphatidylinositol 3-kinase (PI3K) suppresses HP-NAP-induced release of histamine and IL-6 from HMC-1 cells. hp-nap 83-89 interleukin 6 Homo sapiens 123-127 25560300-7 2015 BDNF Val66Met interacted with both IL-1beta rs13032029 (Val/Met+ TT, PPerm = 0.029), and IL-6 rs2069837 (Val/Val+ AA, PPerm = 0.021) in Europeans, in addition to IL-1beta rs16944 (Val/Val+ GA, PPerm = 0.006) in African Americans. Valine 5-8 interleukin 6 Homo sapiens 89-93 25451575-3 2014 In LPS-induced RAW 264.7 macrophages, 7-HMIA significantly inhibited the release of proinflammatory mediators such as prostaglandin E2 (PGE2), nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6). 7-hydroxyl-1-methylindole-3-acetonitrile 38-44 interleukin 6 Homo sapiens 207-220 25451575-3 2014 In LPS-induced RAW 264.7 macrophages, 7-HMIA significantly inhibited the release of proinflammatory mediators such as prostaglandin E2 (PGE2), nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6). 7-hydroxyl-1-methylindole-3-acetonitrile 38-44 interleukin 6 Homo sapiens 222-226 25126764-0 2014 Low molecular weight hyaluronan mediated CD44 dependent induction of IL-6 and chemokines in human dermal fibroblasts potentiates innate immune response. Hyaluronic Acid 21-31 interleukin 6 Homo sapiens 69-73 25530926-10 2014 Furthermore, undiluted daily PF latanoprost application significantly increased LDH release and IL-6 secretion as compared to PF tafluprost. Latanoprost 32-43 interleukin 6 Homo sapiens 96-100 25317773-5 2014 Furthermore, isoorientin dose-dependently reduced levels of interleukin 6 in tumor necrosis factor alpha-alpha-treated immortalized human keratinocytes cells. homoorientin 13-24 interleukin 6 Homo sapiens 60-73 25243720-7 2014 A reversed ligation sequence using glycopeptide hydrazides gave full-length IL-6 glycoproteins, which showed full bioactivity after efficient refolding and purification. glycopeptide hydrazides 35-58 interleukin 6 Homo sapiens 76-80 25224607-7 2014 Direct/oxidative DNA damage at 40 microg ml(-1) and increased IL-6 release at 5 microg ml(-1) were found only in A549 cells after 2 h. The secretion of pro-inflammatory cytokine IL-6, involved in the early acute inflammatory response, and oxidative DNA damage indicate the promotion of early and transient oxidative-inflammatory effects of tested TiO2 -NPs on human alveolar cells. titanium dioxide 347-351 interleukin 6 Homo sapiens 178-182 25313576-11 2014 Inflammatory biomarker concentrations decreased markedly across the quintiles of carotenoid component score (P< 0 001 for hs-CRP and IL-6, and P= 0 016 for E-selectin; ANCOVA). Carotenoids 81-91 interleukin 6 Homo sapiens 136-140 24690561-0 2014 A new signal amplification strategy of photoelectrochemical immunoassay for highly sensitive interleukin-6 detection based on TiO2/CdS/CdSe dual co-sensitized structure. titanium dioxide 126-130 interleukin 6 Homo sapiens 93-106 24690561-1 2014 Dual co-sensitized structure of TiO2/CdS/CdSe was designed to develop a novel photoelectrochemical immunoassay for highly sensitive detection of human interleukin-6 (IL-6). titanium dioxide 32-36 interleukin 6 Homo sapiens 151-164 24690561-1 2014 Dual co-sensitized structure of TiO2/CdS/CdSe was designed to develop a novel photoelectrochemical immunoassay for highly sensitive detection of human interleukin-6 (IL-6). titanium dioxide 32-36 interleukin 6 Homo sapiens 166-170 24690561-2 2014 To construct a sensing electrode, TiO2/CdS hybrid was prepared by successive adsorption and reaction of Cd(2+) and S(2-) ions on the surface of TiO2 and then was employed as matrix for immobilization of anti-IL-6 antibody, whereas CdSe QDs linked to IL-6 were used for signal amplification via the specific antibody-antigen immunoreaction between anti-IL-6 and IL-6-CdSe bioconjugate. titanium dioxide 34-38 interleukin 6 Homo sapiens 208-212 24690561-2 2014 To construct a sensing electrode, TiO2/CdS hybrid was prepared by successive adsorption and reaction of Cd(2+) and S(2-) ions on the surface of TiO2 and then was employed as matrix for immobilization of anti-IL-6 antibody, whereas CdSe QDs linked to IL-6 were used for signal amplification via the specific antibody-antigen immunoreaction between anti-IL-6 and IL-6-CdSe bioconjugate. titanium dioxide 34-38 interleukin 6 Homo sapiens 250-254 24690561-2 2014 To construct a sensing electrode, TiO2/CdS hybrid was prepared by successive adsorption and reaction of Cd(2+) and S(2-) ions on the surface of TiO2 and then was employed as matrix for immobilization of anti-IL-6 antibody, whereas CdSe QDs linked to IL-6 were used for signal amplification via the specific antibody-antigen immunoreaction between anti-IL-6 and IL-6-CdSe bioconjugate. titanium dioxide 34-38 interleukin 6 Homo sapiens 250-254 24690561-2 2014 To construct a sensing electrode, TiO2/CdS hybrid was prepared by successive adsorption and reaction of Cd(2+) and S(2-) ions on the surface of TiO2 and then was employed as matrix for immobilization of anti-IL-6 antibody, whereas CdSe QDs linked to IL-6 were used for signal amplification via the specific antibody-antigen immunoreaction between anti-IL-6 and IL-6-CdSe bioconjugate. titanium dioxide 34-38 interleukin 6 Homo sapiens 250-254 25198673-2 2014 We also examined mucosal expression of IL-6, which stimulates excess GAG synthesis in disorders such as Grave"s ophthalmopathy. Glycosaminoglycans 69-72 interleukin 6 Homo sapiens 39-43 24877691-6 2014 ZO-NP was found to inhibit the productions and mRNA expressions of inflammatory cytokines such as interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha on the phorbol 12-myristate 13-acetate plus A23187 (PMACI)-stimulated human mast cell line, HMC-1 cells. Calcimycin 204-210 interleukin 6 Homo sapiens 122-159 25284569-7 2014 Production of PGE2, TGFbeta and IL6 by Phenytoin induced gingival fibroblasts in children was increased as compared to adults (p < 0.05). Phenytoin 39-48 interleukin 6 Homo sapiens 32-35 25284569-9 2014 CONCLUSION: Phenytoin induced gingival fibroblasts of children produce more amounts of IL1beta, PGE2, IL6, TGFbeta and IL8 as compared to adults" fibroblasts. Phenytoin 12-21 interleukin 6 Homo sapiens 102-105 25216518-9 2014 NVP-BEZ235 was the only drug able to block IL4 and IL6/STAT3 signaling which compromise the therapeutic effect of chemotherapy in MCL. dactolisib 4-10 interleukin 6 Homo sapiens 51-54 24890946-5 2014 Here we report the first adolescent case, successfully treated with anti-IL-6 receptor antibody (tocilizumab, TCZ) and monitored with serial cytokine profiles. tioconazole 110-113 interleukin 6 Homo sapiens 73-77 24589569-5 2014 TET significantly inhibited the induction of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 by phorbol 12-myristate 13-acetate (PMA) plus A23187. tetrandrine 0-3 interleukin 6 Homo sapiens 111-129 24589569-9 2014 Furthermore, TET suppressed the expression of TNF-alpha, IL-8, IL-6 and COX-2 through suppression of the ERK1/2, JNK1/2, IkappaBalpha degradation and phosphorylation, and NF-kappaB activation. tetrandrine 13-16 interleukin 6 Homo sapiens 63-67 24964617-6 2014 RESULTS: The section of the IL-6, TNF-alpha, IL-1beta and IL-8 were the highest when THP-1 cells were exposed to NiSO4, DNCB and K2Cr2O7 for 6h, PPDA and TDI for 12h. Toluene 2,4-Diisocyanate 154-157 interleukin 6 Homo sapiens 28-32 24964617-7 2014 The production of IL-6 were approximately 40, 25, 20, 50 and 50 times for five kinds chemical allergens NiSO4, DNCB, K2Cr2O7, PPDA and TDI respectively at the optimum time points and the optimal concentration compared to the control group. Toluene 2,4-Diisocyanate 135-138 interleukin 6 Homo sapiens 18-22 24722336-6 2014 RESULTS: We found that significant dose-dependent relationships between four urinary OH-PAHs and IL-6 (all Ptrend<0.05); and an increase in quartiles of IL-6 was significantly associated with a decrease in total power (TP) and low frequency (LF) (Ptrend = 0.014 and 0.006, respectively). oh-pahs 85-92 interleukin 6 Homo sapiens 97-101 24722336-6 2014 RESULTS: We found that significant dose-dependent relationships between four urinary OH-PAHs and IL-6 (all Ptrend<0.05); and an increase in quartiles of IL-6 was significantly associated with a decrease in total power (TP) and low frequency (LF) (Ptrend = 0.014 and 0.006, respectively). oh-pahs 85-92 interleukin 6 Homo sapiens 156-160 24419251-5 2014 RESULTS: The IL-17A, IL-6, IL-22 and IFN-gamma were significantly reduced in a dose response after simvastatin treatment (50 muM, p = 0.0005; p < 0.0001; p < 0.02; p = 0.0005, respectively). Simvastatin 99-110 interleukin 6 Homo sapiens 21-25 24419251-6 2014 The IL-17A and IL-6 cytokines were also significantly reduced in lower concentrations of simvastatin (10 muM) compared to controls (p = 0.018; p = 0.04) and compared to the standard drug (p = 0.007; p = 0.0001). Simvastatin 89-100 interleukin 6 Homo sapiens 15-19 24684779-7 2014 RESULTS: Simvastatin significantly reduced plasma interleukin-6, leptin, resistin and monocyte chemoattractant protein-1 (p < 0.001 for all); pioglitazone reduced interleukin-6, tumoral necrose factor-alpha, resistin and matrix metalloproteinase-9 (p < 0.001 for all). Simvastatin 9-20 interleukin 6 Homo sapiens 50-63 24684779-8 2014 Simvastatin + pioglitazone treatment further reduced plasmatic variables, including interleukin-6, tumoral necrose factor-alpha, resistin, asymmetric dimethylarginine and metalloproteinase-9 vs. the control group (p < 0.001). Simvastatin 0-11 interleukin 6 Homo sapiens 84-97 24415057-2 2014 We found that local cationic anesthetics such as procaine, lidocaine and tetracaine greatly facilitated the electroporation of AT2 rat prostate carcinoma cells and human skin fibroblasts (HSF). Lidocaine 59-68 interleukin 6 Homo sapiens 188-191 24296301-9 2014 Antioxidant treatments (deferoxamine mesylate, (+-)alpha-tocopherol, or tempol) suppressed BDE-47-stimulated IL-6 release by 54.1%, 56.3% and 37.7%, respectively, implicating a role for ROS in the regulation of inflammatory pathways in HTR-8/SVneo cells. alpha-Tocopherol 51-67 interleukin 6 Homo sapiens 109-113 26155144-2 2014 In light of its known biological functions and its involvement in tissue pathology in other disease states, particularly in nickel-induced allergic contact dermatitis coexisting with DH, it would appear that the central and peripheral response by neutrophils and their mediators (e.g. neutrophil elastase - NE) in DH may be partially mediated by interleukin-6 (IL-6). Nickel 124-130 interleukin 6 Homo sapiens 346-359 26155144-2 2014 In light of its known biological functions and its involvement in tissue pathology in other disease states, particularly in nickel-induced allergic contact dermatitis coexisting with DH, it would appear that the central and peripheral response by neutrophils and their mediators (e.g. neutrophil elastase - NE) in DH may be partially mediated by interleukin-6 (IL-6). Nickel 124-130 interleukin 6 Homo sapiens 361-365 25382335-10 2014 The mRNA expressions of IL-1alpha, IL-6, IL-8, and TNF-a in different concentrations of SDBS at different time were comparable with that of controls. dodecylbenzenesulfonic acid 88-92 interleukin 6 Homo sapiens 35-39 24309487-8 2014 Additionally, AoPWV was significantly positively associated with inflammatory parameters: IL-6 (R = 0.35; P = 0.009), TGF-beta1 (R = 0.27; P = 0.047), and white blood cell (WBC) count (R = 0.33; P = 0.01). aopwv 14-19 interleukin 6 Homo sapiens 90-94 25341565-6 2014 Furthermore, salidroside attenuates the expression of intercellular adhesion molecule 1 and IL-6 through modulating the activities of p38 MAPK and NF-kappaB in the BEAS-2B cells stimulated by proinflammatory cytokines. rhodioloside 13-24 interleukin 6 Homo sapiens 92-96 23969030-10 2013 These findings suggested that higher 24h overall levels of sputum IL-6, TNF-alpha and flattened diurnal salivary cortisol slopes were associated with depression in lung cancer patients. 9-(3-hydroxy-2-phosphonomethoxypropyl)guanine 37-40 interleukin 6 Homo sapiens 66-70 23933845-3 2013 The aim of this study was to explore the effects of PT and the peptidomimetic natural products, Dhurrin and Prunasin, on the expression of the IL-6, IL-8, IL-23, HSP70 and ICAM-1 on IFN-gamma and TNF-alpha-NHEK activated cells. prunasin 108-116 interleukin 6 Homo sapiens 143-147 23851002-10 2013 p38 knockdown reduced SM-induced secretion of all the cytokines examined, whereas significant reduction in SM-induced cytokine secretion was only observed with TNF-alpha and IL-6 following MK2 knockdown. Samarium 107-109 interleukin 6 Homo sapiens 174-178 23479238-8 2013 The combination (BF + STI) of both traumatic insults induced an increase in mean levels of inflammatory parameters (IL-6: 189.1 pg/mL) but not in MPO levels (1.21 ng/mL) as compared with the BF (0.82 ng/mL) and STI (1.26 ng/mL) groups. benzo(b)fluoranthene 17-19 interleukin 6 Homo sapiens 116-120 23743397-0 2013 Short-term acetaminophen consumption enhances the exercise-induced increase in Achilles peritendinous IL-6 in humans. Acetaminophen 11-24 interleukin 6 Homo sapiens 102-106 23890848-4 2013 RESULTS: A combination of EPA and DHA significantly reduced the concentration of IL-8 and IL-6 released into the supernatant compared to untreated controls (p<0.001). Eicosapentaenoic Acid 26-29 interleukin 6 Homo sapiens 90-94 23588308-4 2013 Elevated simvastatin area under the plasma concentration-time curve (AUC) in virtual rheumatoid arthritis (RA) patients, following 100 pg/ml of IL-6, was comparable to observed clinical data (59 vs. 58%). Simvastatin 9-20 interleukin 6 Homo sapiens 144-148 23588308-5 2013 In virtual bone marrow transplant (BMT) patients, 500 pg/ml of IL-6 resulted in an increase in cyclosporine AUC, also in good agreement with the observed data (45 vs. 39%). cyclosporine auc 95-111 interleukin 6 Homo sapiens 63-67 22447331-8 2013 IL-2 and IL-6 were significantly decreased after the administration of tacrolimus (p = 0.027 and p = 0.024). Tacrolimus 71-81 interleukin 6 Homo sapiens 9-13 22926083-0 2013 Elevated ratio of arachidonic acid to long-chain omega-3 fatty acids predicts depression development following interferon-alpha treatment: relationship with interleukin-6. long-chain omega-3 fatty acids 38-68 interleukin 6 Homo sapiens 157-170 23564008-0 2013 The concentrations of IL-8 and IL-6 in gingival crevicular fluid during nickel-chromium alloy porcelain crown restoration. Nickel 72-78 interleukin 6 Homo sapiens 31-35 22410655-1 2013 BACKGROUND: A guanine/cytosine (G/C) substitution occurring in position -174 of the interleukin-6 (IL-6) gene promoter changes the expression of IL-6 circulating proteins. guanine/cytosine 14-30 interleukin 6 Homo sapiens 84-97 22410655-1 2013 BACKGROUND: A guanine/cytosine (G/C) substitution occurring in position -174 of the interleukin-6 (IL-6) gene promoter changes the expression of IL-6 circulating proteins. guanine/cytosine 14-30 interleukin 6 Homo sapiens 99-103 22410655-1 2013 BACKGROUND: A guanine/cytosine (G/C) substitution occurring in position -174 of the interleukin-6 (IL-6) gene promoter changes the expression of IL-6 circulating proteins. guanine/cytosine 14-30 interleukin 6 Homo sapiens 145-149 23624824-8 2013 Importantly, pretreatment of PC12 cells with exogenous application of sodium hydrosulfide (a H2S donor, 400 mumol/l) for 30 min before exposure to CoCl2 markedly attenuated chemical hypoxia-stimulated iNOS and nNOS expression, NO generation and IL-6 secretion as well as p38MAPK phosphorylation in PC12 cells. cobaltous chloride 147-152 interleukin 6 Homo sapiens 245-249 23624712-0 2013 4-Chlorobenzoyl berbamine, a novel berbamine derivative, induces apoptosis in multiple myeloma cells through the IL-6 signal transduction pathway and increases FOXO3a-Bim expression. berbamine 16-25 interleukin 6 Homo sapiens 113-117 23624712-7 2013 To investigate the mechanisms responsible for BBD9-induced apoptosis, U266 cells were incubated with 0, 1 or 2 microg/ml of BBD9 combined with 0 or 150 ng/ml of interleukin (IL)-6. bbd9 46-50 interleukin 6 Homo sapiens 161-179 23624712-9 2013 Furthermore, BBD9 inhibited autocrine IL-6 production, and downregulated membrane IL-6 receptor (IL-6R) expression. bbd9 13-17 interleukin 6 Homo sapiens 38-42 23624712-10 2013 Crucial proteins downstream of the IL-6 signaling pathway, including AKT and STAT3, were inactivated in BBD9-treated U266 cells, although exogenous IL-6 did not abrogate this effect. bbd9 104-108 interleukin 6 Homo sapiens 35-39 23246638-8 2013 Moreover the antipsychotics, haloperidol and risperidone, were able to inhibit the secretion of S100B following IL-6 stimulation in C6 glioma cells. Haloperidol 29-40 interleukin 6 Homo sapiens 112-116 23690956-8 2013 Further investigation of the underlying mechanism revealed simvastatin could exert the anti-tumor effects by suppressing IL-6-induced phosphorylation of JAK2 and STAT3. Simvastatin 59-70 interleukin 6 Homo sapiens 121-125 22915623-7 2013 RESULTS: Simvastatin decreased IL-17-induced IL-6, IL-8, CX3CL-1, RANTES mRNA and CX3CL-1 and CCL20 production. Simvastatin 9-20 interleukin 6 Homo sapiens 45-49 23361365-0 2013 Docosahexaenoic acid and eicosapentaenoic acid reduce C-reactive protein expression and STAT3 activation in IL-6-treated HepG2 cells. Eicosapentaenoic Acid 25-46 interleukin 6 Homo sapiens 108-112 23361365-4 2013 The aims of this study were to examine the effect of the n-3 PUFAs, docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA), on the modulation of IL-6-induced CRP expression and to explore its possible mechanisms. Eicosapentaenoic Acid 100-121 interleukin 6 Homo sapiens 150-154 23361365-4 2013 The aims of this study were to examine the effect of the n-3 PUFAs, docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA), on the modulation of IL-6-induced CRP expression and to explore its possible mechanisms. Eicosapentaenoic Acid 123-126 interleukin 6 Homo sapiens 150-154 23361365-5 2013 We demonstrated that DHA and EPA inhibited IL-6-induced CRP protein and mRNA expression, as well as reduced CRP promoter activity in HepG2 cells. Eicosapentaenoic Acid 29-32 interleukin 6 Homo sapiens 43-47 23361365-7 2013 Gel electrophoresis mobility shift assays (EMSA) showed that pretreatment with DHA and EPA decreased IL-6-induced STAT3 DNA binding activity but not C/EBPbeta. Eicosapentaenoic Acid 87-90 interleukin 6 Homo sapiens 101-105 23361365-8 2013 By western blot analysis, DHA and EPA inhibited IL-6-induced STAT3 phosphorylation but not ERK1/2 or C/EBPbeta. Eicosapentaenoic Acid 34-37 interleukin 6 Homo sapiens 48-52 23434081-6 2013 IL-6 in piglet plasma of the AAP group (mixed feed concentration of 600 mg/kg) was significantly reduced (P<0.05) at 3h after LPS-challenge as compared with the LPS control group. Acetaminophen 29-32 interleukin 6 Homo sapiens 0-4 23356870-4 2013 GYY4137 (0.1-0.5 mM) decreased LPS-induced production of nitrite (NO2 (-) ), PGE2 , TNF-alpha and IL-6 from HFLS and HAC, reduced the levels and catalytic activity of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and reduced LPS-induced NF-kappaB activation in vitro. GYY 4137 0-7 interleukin 6 Homo sapiens 98-102 23395494-10 2013 Such mucosal side effects may be explained by similar inflammatory mechanisms but appear paradoxical because TCZ inhibits a pro-inflammatory cytokine, interleukin 6. tioconazole 109-112 interleukin 6 Homo sapiens 151-164 23379498-10 2013 The levels of IL-6, IL-10 and TNF-alpha decreased (P < 0.05) in the PHVHF group more significantly than the CVVH group (P < 0.01). phvhf 71-76 interleukin 6 Homo sapiens 14-18 22922248-0 2013 Simvastatin prevents the induction of interleukin-6 gene expression by titanium particles in human osteoblastic cells. Simvastatin 0-11 interleukin 6 Homo sapiens 38-51 22922248-5 2013 We hypothesized that simvastatin (Simv) could modulate the osteoblastic response to titanium particles (Ti) by attenuating the production of IL-6. Simvastatin 21-32 interleukin 6 Homo sapiens 141-145 22922248-5 2013 We hypothesized that simvastatin (Simv) could modulate the osteoblastic response to titanium particles (Ti) by attenuating the production of IL-6. Simvastatin 34-38 interleukin 6 Homo sapiens 141-145 24348674-4 2013 MH7A cells were stimulated with IL1 beta and then treated with different concentrations of 1,25(OH)2D3 for 48 h. A significantly elevated OPG/RANKL ratio and markedly decreased levels of IL-6 and TNF beta mRNA expression in cells and IL-6 protein in supernatants were observed in IL1 beta -induced MH7A in the presence of 1,25(OH)2D3 compared with those in the absence of it. 25(oh)2d3 93-102 interleukin 6 Homo sapiens 187-191 24348674-4 2013 MH7A cells were stimulated with IL1 beta and then treated with different concentrations of 1,25(OH)2D3 for 48 h. A significantly elevated OPG/RANKL ratio and markedly decreased levels of IL-6 and TNF beta mRNA expression in cells and IL-6 protein in supernatants were observed in IL1 beta -induced MH7A in the presence of 1,25(OH)2D3 compared with those in the absence of it. mh7a 0-4 interleukin 6 Homo sapiens 187-191 24348674-4 2013 MH7A cells were stimulated with IL1 beta and then treated with different concentrations of 1,25(OH)2D3 for 48 h. A significantly elevated OPG/RANKL ratio and markedly decreased levels of IL-6 and TNF beta mRNA expression in cells and IL-6 protein in supernatants were observed in IL1 beta -induced MH7A in the presence of 1,25(OH)2D3 compared with those in the absence of it. mh7a 0-4 interleukin 6 Homo sapiens 234-238 23306184-5 2013 Preliminary data suggest the efficacy of the IL-6 receptor inhibitor tocilizumab (TCZ) in patients with LVV. 4-[(4-methylphenyl)methyl]-1,4-thiazinane 1,1-dioxide 104-107 interleukin 6 Homo sapiens 45-49 23843863-9 2013 S-[6]-Gingerol attenuated IL1beta-induced inflammation and oxidative stress in HuH7 cells, as evidenced by decreasing mRNA levels of inflammatory factor IL6, IL8, and SAA1, suppression of ROS generation, and increasing mRNA levels of DHCR24. gingerol 0-14 interleukin 6 Homo sapiens 153-156 23843863-11 2013 Similar to the protective effects of S-[6]-gingerol, both NS-398 (a selective COX2 inhibitor) and PDTC (a selective NF kappa B inhibitor) suppressed mRNA levels of IL6, IL8, and SAA1. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 58-64 interleukin 6 Homo sapiens 164-167 23983782-6 2013 Results showed that the hyperglycemia-induced GAG alterations in the cell surface perlecan as well as in the ECM indeed upregulated the expressions of IL-6, IL-8, and MCP-1 and the activities of MMP-2 and MMP-9 and downregulated the expressions of TIMP-2. Glycosaminoglycans 46-49 interleukin 6 Homo sapiens 151-155 23394103-10 2013 There was a positive correlation between uric acid and inflammatory markers, IL-6 (r = 0.30, p = 0.01), CRP (r = 0.37, p = 0.003), TNF-alpha (r = 0.40, p = 0.001), ICAM-1 (r = 0.53, p = 0.0001), and VCAM-1 (r = 0.45, p = 0.0001). Uric Acid 41-50 interleukin 6 Homo sapiens 77-81 24175257-6 2012 Cyclosporine A (CsA) and tacrolimus (Tac) are T-cell-specific calcineurin inhibitors that prevent the activation of helper T cells, thereby inhibiting the transcription of the early activation genes of interleukin (IL)-2 and suppressing T cell-induced activation of tumor necrosis factor-alpha, IL-1beta and IL-6. Tacrolimus 25-35 interleukin 6 Homo sapiens 308-312 24175257-6 2012 Cyclosporine A (CsA) and tacrolimus (Tac) are T-cell-specific calcineurin inhibitors that prevent the activation of helper T cells, thereby inhibiting the transcription of the early activation genes of interleukin (IL)-2 and suppressing T cell-induced activation of tumor necrosis factor-alpha, IL-1beta and IL-6. Tacrolimus 37-40 interleukin 6 Homo sapiens 308-312 23089469-0 2012 High therapeutic concentration of prazosin up-regulates angiogenic IL6 and CCL2 genes in hepatocellular carcinoma cells. Prazosin 34-42 interleukin 6 Homo sapiens 67-70 23089469-4 2012 This study was to investigate the influence of therapeutic concentrations of prazosin (0.01 and 0.1muM) on cell proliferation and differential expressions of CCL2, CCL20, CXCL6, CXCL10, IL8 and IL6 genes related to inflammation and/or oxidative stress in human HCC cell lines. Prazosin 77-85 interleukin 6 Homo sapiens 194-197 23089469-10 2012 However, 0.1muM prazosin caused remarkable up-regulation of IL6 gene and slightly up-regulation of CCL2 gene in cell line B. Prazosin 16-24 interleukin 6 Homo sapiens 60-63 23089469-11 2012 In conclusion, high therapeutic concentration of prazosin can up-regulate angiogenic IL6 and CCL2 genes in human HCC cells susceptible to amphotericin B-induced oxidative stress. Prazosin 49-57 interleukin 6 Homo sapiens 85-88 23285694-7 2012 GHK and their copper complexes and saccharomyces/copper ferment (Oligolides Copper) on secretion of pro-inflammatory IL-6 in normal human dermal fibroblasts NHDF cell line. glycyl-histidyl-lysine 0-3 interleukin 6 Homo sapiens 117-121 23285694-9 2012 GGH, GHK, CuCl2 and their copper complexes decreased TNF-alpha-dependent IL-6 secretion in fibroblasts. glycyl-histidyl-lysine 5-8 interleukin 6 Homo sapiens 73-77 23241116-4 2012 IL-1&#223; and IL-6 up-regulation, induced by CyA, was counteracted by the addition of EPA in both protocols; on the contrary, arachidonic acid (AA) magnified CyA the effects. Eicosapentaenoic Acid 91-94 interleukin 6 Homo sapiens 19-23 22486775-7 2012 RESULTS: Lower plasma levels of total and single carotenoids were associated with lower dietary intake of carotenoids, older age, male sex, lower physical activity, higher alcohol consumption, higher body mass index (BMI), higher systolic and diastolic blood pressures, lower levels of total cholesterol and HDL cholesterol and higher levels of CRP, IL-6 and MMP-9. Carotenoids 49-60 interleukin 6 Homo sapiens 350-354 22486775-8 2012 After multivariate adjustments, plasma levels of total carotenoids and provitamin A carotenoids (beta-cryptoxanthine, alpha-carotene and beta-carotene) remained independently associated with sex, dietary intake of carotenoids, BMI, HDL cholesterol and MMP-9, whilst associations with CRP and IL-6 were not maintained. Carotenoids 55-66 interleukin 6 Homo sapiens 292-296 22796581-8 2012 Simvastatin significantly reduced plasma troponin T, isoenzyme of creatine kinase, C-reaction protein, blood urea nitrogen , creatinine, interleukin-6, interleukin-8, and the requirement of inotropic postoperatively. Simvastatin 0-11 interleukin 6 Homo sapiens 137-150 22887873-6 2012 In human monocytes, high purity PETIM-DG potently inhibited Shigella Lipid A-induced IL-6 expression. polypropyletherimine dendrimer glucosamine 32-40 interleukin 6 Homo sapiens 85-89 22560881-3 2012 In the present study, we reported that in the animal model of LPS-induced liver injury, administration of the FXR natural ligand CDCA could attenuate hepatocyte inflammatory damage, reduce transaminase activities, suppress inflammation mediators (IL-6, TNF-alpha and ICAM-1) expression and inhibit STAT3 phosphorylation. Chenodeoxycholic Acid 129-133 interleukin 6 Homo sapiens 247-251 22343219-3 2012 In the present study, we demonstrate that cell-surface beta-glucan components of Pneumocystis (PCBG) stimulate human dendritic cells (DCs) to secrete IL-23 and IL-6. S-(1,2,3,4,4-Pentachloro-1,3-butadienyl)glutathione 95-99 interleukin 6 Homo sapiens 160-164 22547109-10 2012 We further showed that RO429097 inhibits normal T-cell synthesis of some inflammatory cytokines, including TNF-alpha, a potential mediator of IL-6 and IL-8 production in the microenvironment. ro429097 23-31 interleukin 6 Homo sapiens 142-146 22445541-3 2012 Here, we showed that staphylococcal LTA (Sa.LTA) substantially enhanced IL-6 expression at both the protein and the mRNA levels in the human basophil line, KU812, in the presence of a PKC activator (phorbol 12-myristrate 13-acetate; PMA), and a calcium ionophore (A23187), whereas Sa.LTA alone could not induce IL-6 expression. phorbol 12-myristrate 13-acetate 199-231 interleukin 6 Homo sapiens 72-76 22445541-3 2012 Here, we showed that staphylococcal LTA (Sa.LTA) substantially enhanced IL-6 expression at both the protein and the mRNA levels in the human basophil line, KU812, in the presence of a PKC activator (phorbol 12-myristrate 13-acetate; PMA), and a calcium ionophore (A23187), whereas Sa.LTA alone could not induce IL-6 expression. phorbol 12-myristrate 13-acetate 199-231 interleukin 6 Homo sapiens 311-315 22445541-3 2012 Here, we showed that staphylococcal LTA (Sa.LTA) substantially enhanced IL-6 expression at both the protein and the mRNA levels in the human basophil line, KU812, in the presence of a PKC activator (phorbol 12-myristrate 13-acetate; PMA), and a calcium ionophore (A23187), whereas Sa.LTA alone could not induce IL-6 expression. Calcimycin 264-270 interleukin 6 Homo sapiens 72-76 22445541-7 2012 Experiments using human peripheral blood mononuclear cells demonstrated that not only PMA/A23187 but also Sa.LTA increased the intracellular IL-6 expression in the basophil population and Sa.LTA plus PMA/A23187 further enhanced the IL-6 expression. Calcimycin 90-96 interleukin 6 Homo sapiens 141-145 22445541-7 2012 Experiments using human peripheral blood mononuclear cells demonstrated that not only PMA/A23187 but also Sa.LTA increased the intracellular IL-6 expression in the basophil population and Sa.LTA plus PMA/A23187 further enhanced the IL-6 expression. Calcimycin 90-96 interleukin 6 Homo sapiens 232-236 23798923-8 2012 CONCLUSIONS: Eight-week supplementation with quercein-vitamin C was effective in reducing oxidative stress and reducing inflammatory biomarkers including CRP and IL-6 with little effect on E-selectin in healthy subjects. quercein-vitamin c 45-63 interleukin 6 Homo sapiens 162-166 21340508-6 2012 In addition, we found that isoxanthohumol blocked IFN-gamma, IL-4 and IL-6 dependent Jak/Stat signaling and strongly inhibited the induction of pro-inflammatory genes in MonoMac6 cells at the transcriptional level after LPS/TPA treatment. isoxanthohumol 27-41 interleukin 6 Homo sapiens 70-74 22421411-3 2012 In this study we investigated the effects of disease-relevant cytokines, such as interleukin-6 (IL-6) and osteopontin (OPN), on the in vitro antimyeloma activity of erufosine and perifosine. erucylphospho-N,N,N-trimethylpropylammonium 165-174 interleukin 6 Homo sapiens 81-94 22421411-3 2012 In this study we investigated the effects of disease-relevant cytokines, such as interleukin-6 (IL-6) and osteopontin (OPN), on the in vitro antimyeloma activity of erufosine and perifosine. erucylphospho-N,N,N-trimethylpropylammonium 165-174 interleukin 6 Homo sapiens 96-100 22421411-5 2012 Exogenous IL-6 reduced the cytotoxicity of erufosine against OPM-2 cells and, to a smaller extent, against U-266 cells. erucylphospho-N,N,N-trimethylpropylammonium 43-52 interleukin 6 Homo sapiens 10-14 22932481-8 2012 The relative mRNA level of IL-6 in hPDLC treated with 10(-10) mol/L E(2) or 10(-7) mol/L E(2) combined with Pg were 0.49 +- 0.15 (P = 0.021)and 0.53 +- 0.16 (P = 0.036) individually, which were significantly higher than that treated with Pg alone, 0.19 +- 0.06. hpdlc 35-40 interleukin 6 Homo sapiens 27-31 21344174-8 2012 Theanine also repressed phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced TNF-alpha, IL-1beta, IL-6, and IL-8 secretion by suppressing NF-kappaB activation. Calcimycin 78-84 interleukin 6 Homo sapiens 114-118 22415150-11 2012 CONCLUSIONS: The SH-CL and CH-CL wear is associated with elevation of IL-6 and IL-8 levels in the tears of healthy, nonatopic neophyte CL users. ch-cl 27-32 interleukin 6 Homo sapiens 70-74 22763297-5 2012 RESULTS: During the course of the study, the average level of IL-6 was significantly (p<0.05) higher in patients with SAAP than in patients with the mild form of the disease (MAAP). saap 121-125 interleukin 6 Homo sapiens 62-66 22763297-5 2012 RESULTS: During the course of the study, the average level of IL-6 was significantly (p<0.05) higher in patients with SAAP than in patients with the mild form of the disease (MAAP). maap 178-182 interleukin 6 Homo sapiens 62-66 22763297-8 2012 CONCLUSIONS: Patients with SAAP had significantly higher proinflammatory cytokine IL-6 levels and neutrophil counts than patients with MAAP. saap 27-31 interleukin 6 Homo sapiens 82-86 22322153-7 2012 PFOA induced gene expression of pro-inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8 in mast cells. perfluorooctanoic acid 0-4 interleukin 6 Homo sapiens 126-130 22293775-0 2012 gamma-Tocotrienol attenuates TNF-alpha-induced changes in secretion and gene expression of MCP-1, IL-6 and adiponectin in 3T3-L1 adipocytes. plastochromanol 8 0-17 interleukin 6 Homo sapiens 98-102 22804935-5 2012 The relative gene expression and protein expression of IL-6 and TNF-alpha enhanced with the reduced concentrations of RU486, which were the lowest when RU486 concentration was 10(-7) mol/L, as compared with control and PQ exposure groups (P < 0.01 or P < 0.05), while the change of IL-10 content was the opposite. Paraquat 219-221 interleukin 6 Homo sapiens 55-59 22611924-1 2012 OBJECTIVE: To investigate the effects of citreoviridin (CIT) on the expression of MCP-1, IL-1beta, IL-6 and IL-8 induced by TNF-alpha in human umbilical vein endothelial cells (HUVECs). citreoviridin 41-54 interleukin 6 Homo sapiens 99-103 22611924-1 2012 OBJECTIVE: To investigate the effects of citreoviridin (CIT) on the expression of MCP-1, IL-1beta, IL-6 and IL-8 induced by TNF-alpha in human umbilical vein endothelial cells (HUVECs). citreoviridin 56-59 interleukin 6 Homo sapiens 99-103 21420224-8 2012 RESULTS: The addition of ascorbate to in vitro culture gliadin-challenged biopsies blocked the secretion of nitrites (p=0.013), IFNgamma (p=0.0207), TNFalpha (p=0.0099), IFNalpha (p=0.0375), and IL-6 (p=0.0036) compared to samples from non-ascorbate supplemented culture. Ascorbic Acid 25-34 interleukin 6 Homo sapiens 195-199 23383400-2 2012 Increased serum levels of IL6 and IL17A have been detected in sporadic ALS (sALS) patients when compared to healthy controls. sals 76-80 interleukin 6 Homo sapiens 26-29 23383400-4 2012 At baseline, PBMCs of four sALS patients (Group 1) showed significantly increased expression of TLR2 and CD14; ALOX5, PTGS2 and MMP1; IL1alpha, IL1beta, IL6, IL36G, IL8 and TNF; CCL3, CCL20, CXCL2, CXCL3 and CXCL5. sals 27-31 interleukin 6 Homo sapiens 153-156 22567176-7 2012 In addition, the serum concentration of interleukin-6 (proinflammatory cytokine) was higher in patients compared to controls; and the concentration of tumor-necrosis factor alpha ([TNF-alpha]) was positively correlated to the metabolic activity of the lung tumor as defined by the 2-deoxy-2-((18)F)fluoro-D-glucose ((18)FDG) positron emission tomography (PET) derived maximal standardized uptake values (SUV(max)). fluoro-d-glucose 298-314 interleukin 6 Homo sapiens 40-53 22102722-3 2012 In this study, we found that MSU crystals, through P2Y(6) receptors, stimulated normal human keratinocytes (NHK) to produce IL-1alpha, IL-8/CXCL8, and IL-6. Uric Acid 29-32 interleukin 6 Homo sapiens 151-155 23051896-9 2012 The effects observed on the secretion of IL-6 were more potent than those corresponding to IL-8 and were reduced by ascorbic acid. Ascorbic Acid 116-129 interleukin 6 Homo sapiens 41-45 22036725-11 2012 In addition, SM enhanced phosphorylation of NF-kB p65 and release of TNF-alpha, interleukin (IL)-6 and IL-8. Samarium 13-15 interleukin 6 Homo sapiens 80-98 23487396-7 2011 LPO levels correlated directly with IL-1beta, TNF-alpha, IL-6 and IL-10. Lipid Peroxides 0-3 interleukin 6 Homo sapiens 57-61 21641579-7 2011 The implication of P2Y receptor was exhibited by a significant inhibition of pressure-induced IL-6 expression by suramin, an antagonist for the non-specific purinergic receptor family. Suramin 113-120 interleukin 6 Homo sapiens 94-98 21990194-0 2011 Synthesis of silver nanoparticle-hollow titanium phosphate sphere hybrid as a label for ultrasensitive electrochemical detection of human interleukin-6. Silver 13-19 interleukin 6 Homo sapiens 138-151 21990194-1 2011 A silver nanoparticle-hollow titanium phosphate sphere (AgNP-TiP) hybrid is successfully synthesized and used as a label for electrochemical detection of human interleukin-6 (IL-6). Silver 2-8 interleukin 6 Homo sapiens 160-173 21990194-1 2011 A silver nanoparticle-hollow titanium phosphate sphere (AgNP-TiP) hybrid is successfully synthesized and used as a label for electrochemical detection of human interleukin-6 (IL-6). Silver 2-8 interleukin 6 Homo sapiens 175-179 21477901-11 2011 In addition, both sterol fortified OJ as well as sterol fortified OJBev resulted in significant reductions in serum IL-6 levels (p < 0.01). Sterols 18-24 interleukin 6 Homo sapiens 116-120 21477901-11 2011 In addition, both sterol fortified OJ as well as sterol fortified OJBev resulted in significant reductions in serum IL-6 levels (p < 0.01). Sterols 49-55 interleukin 6 Homo sapiens 116-120 20592661-4 2011 The angiotensin-converting enzyme inhibitors like captopril and enalapril as well as the angiotensin II receptor antagonist losartan indicated in HF exerted reducing effects on the inflammatory cytokines such as tumor necrosis factor-alpha and interleukin-6 at experimental and clinical levels. Captopril 50-59 interleukin 6 Homo sapiens 244-257 21142820-5 2011 Apigenin significantly inhibits the inductive effect of phorbol 12-myristate 13-acetate (PMA) plus A23187 on the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-8, IL-6, and granulocyte-macrophage colony-stimulating factor (GM-CSF). Calcimycin 99-105 interleukin 6 Homo sapiens 213-217 21830898-10 2011 The novel intervention strategies being developed for EPA and RA, such as IL-6 and IL-8 signaling blockade, may also be considered for chronic CHIKV arthritis. Eicosapentaenoic Acid 54-57 interleukin 6 Homo sapiens 74-78 21708999-5 2011 By using a 15-mer antisense phosphorothioate oligonucleotide targeting a sequence in the second exon of the IL-6 gene, modulation of IL-6 and vascular endothelial growth factor (VEGF) expression was examined in UMSCC IIA in cell supernatants by capture enzyme-linked immunosorbent assay (ELISA), and in cell lysates by reverse transcriptase-polymerase chain reaction (RT-PCR). Phosphorothioate Oligonucleotides 28-60 interleukin 6 Homo sapiens 108-112 21708999-5 2011 By using a 15-mer antisense phosphorothioate oligonucleotide targeting a sequence in the second exon of the IL-6 gene, modulation of IL-6 and vascular endothelial growth factor (VEGF) expression was examined in UMSCC IIA in cell supernatants by capture enzyme-linked immunosorbent assay (ELISA), and in cell lysates by reverse transcriptase-polymerase chain reaction (RT-PCR). Phosphorothioate Oligonucleotides 28-60 interleukin 6 Homo sapiens 133-137 21175613-8 2011 RESULTS: At the end of treatment with candesartan, IL-6 levels decreased significantly (P<0 05). candesartan 38-49 interleukin 6 Homo sapiens 51-55 21533553-7 2011 Inhibition of NF-kappaB by PDTC (a selective inhibitor of NF-kappaB) or genetic silencing of p65 by RNAi (Si-p65), attenuated not only the cytotoxicity and secretion of IL-6 and IL-8, but also overexpression of COX-2 in CoCl(2)-treated HaCaT cells. cobaltous chloride 220-227 interleukin 6 Homo sapiens 169-173 21533553-8 2011 Neutralizing anti-IL-6 or anti-IL-8 antibody statistically alleviated CoCl(2)-induced cytotoxicity in HaCaT cells. cobaltous chloride 70-77 interleukin 6 Homo sapiens 18-22 21633597-5 2011 IL-6 induced endothelial cell proliferation was measured with 3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyl tetrazoliumbromide assay, in vitro angiogenesis was determined with endothelial cell tube formation assay in Matrigel, and IL-6-induced angiogenesis in vitro was measured with Matrigel plug assay. thiazolyl blue 62-124 interleukin 6 Homo sapiens 0-4 21866484-9 2011 In epilepsy patients studies (including ex vivo) show elevated levels of IL-1 beta, IL-2, IL-5, IL-6 or TNF- alpha after carbamazepine, valproic acid and phenytoin. Phenytoin 154-163 interleukin 6 Homo sapiens 96-100 21276586-5 2011 Simvastatin and fenofibrate decreased monocyte release of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and monocyte chemoattractant protein-1 and lymphocyte release of interleukin-2, interferon-gamma, and tumor necrosis factor-alpha, which was accompanied by a decrease in plasma C-reactive protein levels. Simvastatin 0-11 interleukin 6 Homo sapiens 106-119 21323660-5 2011 1,25(OH)(2) D(3) decreased interleukin (IL)-6 and tumour necrosis factor (TNF)-alpha release by PBMC stimulated with tripalmitoyl-S-glycerylcysteine (Pam3Cys) or lipopolysaccharide (LPS). tripalmitoyl cysteine 117-148 interleukin 6 Homo sapiens 27-45 21441124-9 2011 Fat percentage, interleukin-6, and adipokines (leptin, adiponectin, and resistin) were strongly associated with GDR. gdr 112-115 interleukin 6 Homo sapiens 16-29 21256188-8 2011 The presence of alpha-tocopherol also modulated the expression of some cytokines, including CCL2, CCL3, IL-6, CSF3 and CXCL1; increased the antigen loading in monocytes; and increased the recruitment of granulocytes in the dLNs. alpha-Tocopherol 16-32 interleukin 6 Homo sapiens 104-108 20946124-8 2011 In human chondrocytes, BK increased release (over 24 h) of IL-6 and IL-8, effects blocked by MEN16132 but not by the B1 receptor antagonist Lys-[Leu8][desArg9]BK. (4-amino-5-(4-(4-(2,4-dichloro-3-(2,4-dimethyl-8-quinolyloxymethyl)phenylsulfonamido)tetrahydro-2H-4-pyranoylcarbonyl)piperazino)-5-oxopentyl)(trimethyl)ammonium 93-101 interleukin 6 Homo sapiens 59-63 21087659-5 2011 Also, exposure to HCHO for 30 min dose-dependently inhibited basal and lipopolysaccharide-induced interleukin-6 (IL-6) and IL-8 production by bronchial epithelial cells. Formaldehyde 18-22 interleukin 6 Homo sapiens 98-111 21087659-5 2011 Also, exposure to HCHO for 30 min dose-dependently inhibited basal and lipopolysaccharide-induced interleukin-6 (IL-6) and IL-8 production by bronchial epithelial cells. Formaldehyde 18-22 interleukin 6 Homo sapiens 113-117 22254128-8 2011 In the fresh samples IL-6 was highest in CRVO (median IL-6 55.8 pg/mL) > DME (50.6) > ARMD (3.1). dme 76-79 interleukin 6 Homo sapiens 21-25 22254128-8 2011 In the fresh samples IL-6 was highest in CRVO (median IL-6 55.8 pg/mL) > DME (50.6) > ARMD (3.1). dme 76-79 interleukin 6 Homo sapiens 54-58 21198209-9 2010 This analysis suggests that the dip probes can detect 5-pM or higher concentration of IL-6 in these samples with specificities of 100%. 3,5-diisopropylsalicylic acid 32-35 interleukin 6 Homo sapiens 86-90 20935477-8 2010 In vitro, ATROSAB inhibited typical TNF-mediated responses like apoptosis induction and activation of NFkappaB-dependent gene expression such as IL-6 and IL-8 production. atrosab 10-17 interleukin 6 Homo sapiens 145-149 20582542-10 2010 CONCLUSIONS: Preincisional parecoxib administration compared to postincisional administration reduced postoperative morphine consumption, but without affecting morphine-related adverse effects and attenuated IL-6 production 24 h after surgery for colorectal cancer. parecoxib 27-36 interleukin 6 Homo sapiens 208-212 20580698-6 2010 In women, there were significant negative associations between serum carotenoids concentrations and serum interleukin-6 (IL-6) concentrations. Carotenoids 69-80 interleukin 6 Homo sapiens 106-119 20580698-6 2010 In women, there were significant negative associations between serum carotenoids concentrations and serum interleukin-6 (IL-6) concentrations. Carotenoids 69-80 interleukin 6 Homo sapiens 121-125 20600219-0 2010 Multiple protein kinase pathways mediate amplified IL-6 release by human lung fibroblasts co-exposed to nickel and TLR-2 agonist, MALP-2. Nickel 104-110 interleukin 6 Homo sapiens 51-55 20711426-12 2010 CONCLUSIONS/SIGNIFICANCE: The results clearly demonstrate that damage to the bronchial epithelia by poly-L-arginine stimulates polarized IL-6 and IL-8 secretion. polyarginine 100-115 interleukin 6 Homo sapiens 137-141 20979906-6 2010 RESULT: The change of the plasma levels of IL-6, IL-8, IL-1RA, TNF, IL-1beta in the two groups:in the parecoxib group the plasma levels of TNF and IL-1beta did not decreased significantly as compared with the control group (P > 0.05). parecoxib 102-111 interleukin 6 Homo sapiens 43-47 20178456-10 2010 The addition of tungstate to cultures resulted in significant reductions in the quantity of interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-alpha), and IL-6 produced by stimulated [CD3/CD28, ConA, or lipopolysaccharide (LPS)] and tungstate-treated lymphocytes. tungstate 16-25 interleukin 6 Homo sapiens 161-165 21055228-8 2010 CONCLUSIONS: Free bile acids (CA, DCA and CDCA) can inhibit the expression of IL-6 and the cell viability, while glycine conjugates (GCA, GDCA and GCDCA) can promote the expression of IL-6 and the cell viability. Chenodeoxycholic Acid 42-46 interleukin 6 Homo sapiens 78-82 21055228-8 2010 CONCLUSIONS: Free bile acids (CA, DCA and CDCA) can inhibit the expression of IL-6 and the cell viability, while glycine conjugates (GCA, GDCA and GCDCA) can promote the expression of IL-6 and the cell viability. Chenodeoxycholic Acid 42-46 interleukin 6 Homo sapiens 184-188 20171758-0 2010 Synthesis and biological evaluation of beta-chloro vinyl chalcones as inhibitors of TNF-alpha and IL-6 with antimicrobial activity. beta-chloro vinyl chalcones 39-66 interleukin 6 Homo sapiens 98-102 20512931-6 2010 In contrast, inhibition of SHP-2 enzymatic activity (sodium stibogluconate) abrogated the increased ERK phosphorylation associated with integrin beta4 silencing in LPS-treated EC and attenuated the increases in levels of IL-6 and IL-8 in integrin-beta4-silenced EC. Antimony Sodium Gluconate 53-74 interleukin 6 Homo sapiens 221-225 19769459-4 2010 For the first time, we show that GYY4137 significantly and concentration-dependently inhibits LPS-induced release of proinflammatory mediators such as IL-1beta, IL-6, TNF-alpha, nitric oxide (*NO), and PGE(2) but increased the synthesis of the antiinflammatory chemokine IL-10 through NF-kappaB/ATF-2/HSP-27-dependent pathways. GYY 4137 33-40 interleukin 6 Homo sapiens 161-165 20495770-5 2010 The plasma concentrations of heparan sulfate and syndecan-1 strongly correlate with severity of sepsis and with inflammatory markers such as interleukin-6 (IL-6). Heparitin Sulfate 29-44 interleukin 6 Homo sapiens 141-154 20495770-5 2010 The plasma concentrations of heparan sulfate and syndecan-1 strongly correlate with severity of sepsis and with inflammatory markers such as interleukin-6 (IL-6). Heparitin Sulfate 29-44 interleukin 6 Homo sapiens 156-160 20463301-8 2010 In addition, WECG attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187-stimulated gene expression and secretion of proinflammatory cytokines such as tumor necrosis factor-alpha and interleukin-6 in human mast cells. Calcimycin 87-93 interleukin 6 Homo sapiens 204-217 20506652-8 2010 The RT-PCR verified the mRNA expression of IL-6 and IL-8 was up-regulated until 48 h after treatment with paraquat. Paraquat 106-114 interleukin 6 Homo sapiens 43-47 20159692-6 2010 CONCLUSION: FK506 effectively inhibits the secretion of proinflammatory cytokines including IL-6, IFN-gamma and TNF-alpha and also the secretion of IL-2, IL-12, IL-17, GM-CSF and G-CSF. Tacrolimus 12-17 interleukin 6 Homo sapiens 92-96 19789931-7 2010 Moreover, AAS significantly inhibited production of inflammatory cytokines, tumor necrosis factor (TNF), interleukin (IL)-6, and IL-8 on the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated human mast cell line, HMC-1 cells. Calcimycin 195-201 interleukin 6 Homo sapiens 105-123 19880789-10 2010 Furthermore, cortisone decreased IL-6 (P < 0.005), IL-8 (P < 0.05), and macrophage chemoattractant protein-1 (P < 0.05) production by cultured TAO cells only, an effect that was abrogated by inhibition of 11beta-HSD1. Cortisone 13-22 interleukin 6 Homo sapiens 33-37 19897675-9 2010 They express TSHR at high levels and TSH induces fibrocytes to produce IL-6 and TNF-alpha. Thyrotropin 13-16 interleukin 6 Homo sapiens 71-75 19669729-2 2009 We sought to assess the associations of circulating levels of IL-6, TNF-alpha and high-sensitivity C reactive protein (hsCRP), which are inflammatory markers related to insulin resistance (IR), with the plasma lipid metabolites ceramides and diacylglycerols (DAG) in patients with CHD. Diglycerides 242-257 interleukin 6 Homo sapiens 62-66 19669729-2 2009 We sought to assess the associations of circulating levels of IL-6, TNF-alpha and high-sensitivity C reactive protein (hsCRP), which are inflammatory markers related to insulin resistance (IR), with the plasma lipid metabolites ceramides and diacylglycerols (DAG) in patients with CHD. Diglycerides 259-262 interleukin 6 Homo sapiens 62-66 19669729-7 2009 After adjustments for the effect of serum inflammatory markers (TNF-alpha or hsCRP), HOMA-IR and BMI the correlation between plasma DAG and serum IL-6 (r = 0.33) was also significant (p < 0.03). Diglycerides 132-135 interleukin 6 Homo sapiens 146-150 19730394-8 2009 In addition, candesartan reduced the activation of the nuclear factor kappa B pathway, the tumor necrosis factor alpha and interleukin-6 secretion, and the ROS formation induced by LPS, without affecting the secretion of interleukin-10. candesartan 13-24 interleukin 6 Homo sapiens 123-136 19525101-8 2009 Interestingly, aminophylline and terbutaline could not only down-regulate the ingestion of apoptotic eosinophils by A549 cells in a time- and dose-dependent manner, but also decrease IL-6 and IL-8 secretion by A549 cells induced by LPS. Terbutaline 33-44 interleukin 6 Homo sapiens 183-187 19525101-9 2009 CONCLUSIONS: The present study showed that all of the investigated anti-asthmatic drugs including dexamethasone, aminophylline and terbutaline play an anti-inflammatory effect by decreasing the release of IL-6 and IL-8 induced by LPS. Aminophylline 113-126 interleukin 6 Homo sapiens 205-209 19525101-9 2009 CONCLUSIONS: The present study showed that all of the investigated anti-asthmatic drugs including dexamethasone, aminophylline and terbutaline play an anti-inflammatory effect by decreasing the release of IL-6 and IL-8 induced by LPS. Terbutaline 131-142 interleukin 6 Homo sapiens 205-209 19865006-8 2009 Penetration of morphine metabolites into the central nervous system increased in proportion to the neuroinflammatory response as demonstrated by the positive correlation between cerebrospinal fluid interleukin-6 exposure and the area under the curve cerebrospinal fluid/plasma ratio for morphine-3-glucuronide (r = .49, p < .001) and morphine-6-glucuronide (r = .51, p < .001). morphine-6-glucuronide 337-359 interleukin 6 Homo sapiens 198-211 19535686-6 2009 S1P induced release of IL-6, a cytokine known to promote development of functionally mature MC(TC)s, from cord blood cultures containing adherent macrophages, and from highly purified macrophages, but not from macrophage-depleted CB-MCs. mc(tc)s 92-99 interleukin 6 Homo sapiens 23-27 19640331-0 2009 Effect of simvastatin on plasma interleukin-6 in patients with unstable angina. Simvastatin 10-21 interleukin 6 Homo sapiens 32-45 19640331-8 2009 Following treatment, the IL-6 levels in the simvastatin group were lower than in the placebo group (0.7+/-0.4 vs 1.2+/-0.4 pg/ml, P < 0.05). Simvastatin 44-55 interleukin 6 Homo sapiens 25-29 19640331-9 2009 CONCLUSIONS: Short-term treatment with simvastatin reduces plasma IL-6. Simvastatin 39-50 interleukin 6 Homo sapiens 66-70 19079838-5 2009 The registered dietary intakes of ascorbic acid and alpha-tocopherol were negatively associated linearly and in quartiles with both PGF2alpha, hsCRP, IL-6 and F2-isoprostanes, where ascorbic acid intake generally was more strongly associated. Ascorbic Acid 34-47 interleukin 6 Homo sapiens 150-154 19079838-5 2009 The registered dietary intakes of ascorbic acid and alpha-tocopherol were negatively associated linearly and in quartiles with both PGF2alpha, hsCRP, IL-6 and F2-isoprostanes, where ascorbic acid intake generally was more strongly associated. alpha-Tocopherol 52-68 interleukin 6 Homo sapiens 150-154 19567922-9 2009 While postexercise IL-6 levels were significantly lower in the CHO trial compared with the placebo trial (5.3+/-1.9 pg.mL(-1) and 6.6+/-3.0 pg.mL(-1), respectively; p=.0313), this difference was considered physiologically too small to mediate the improvement in time trial performance. CAV protocol 63-66 interleukin 6 Homo sapiens 19-23 19296424-10 2009 RESULTS: A reduction of TNF-alpha-induced IL-6 release after treatment with hyaluronic acid and chondroitin sulfate was observed, indicating the anti-inflammatory action of the preparation. Hyaluronic Acid 76-91 interleukin 6 Homo sapiens 42-46 19103208-5 2009 The STAT1 inhibitor, fludarabine, prevented gp120-induced IL-6 and IL-8 secretion. fludarabine 21-32 interleukin 6 Homo sapiens 58-62 18654091-7 2009 Treatment with LQGV, AQGV, or LAGV prevented systemic release of TNF-[alpha] and IL-6 and was associated with reduced TNF-[alpha], IL-6, and E-selectin mRNA transcript levels in the liver. alanyl-glutaminyl-glycyl-valine 21-25 interleukin 6 Homo sapiens 81-85 19070894-6 2009 Treatment of phagocytosing endothelial cells with vitamin C also prevented the increase in IL-6 secretion that normally accompanies phagocytosis of necrotic trophoblasts. Ascorbic Acid 50-59 interleukin 6 Homo sapiens 91-95 18495130-7 2009 Pretreatment of human monocytes with candesartan significantly decreased Pam3CSK4 or LPS induced TLR2 and TLR4 expression of both mRNA and protein levels (P<0.05 vs. control) along with decrease in the activity of NF-kappaB and the expression of IL-1beta, IL-6, TNF-alpha, and MCP-1. candesartan 37-48 interleukin 6 Homo sapiens 259-263 19967068-2 2008 In the present study, we found that specific tyrphostin inhibitors of ErbB2 (AG825 and AG879), but not ErbB1 inhibitor (AG1478), suppressed IL-6-induced tyrosine phosphorylation of STAT3 in schwannoma cells. Tyrphostins 45-55 interleukin 6 Homo sapiens 140-144 18825645-9 2008 CONCLUSIONS: HCO and ETX-A appeared to significantly reduce plasma IL-1ra and, when combined, plasma IL-6 concentration as well. etx-a 21-26 interleukin 6 Homo sapiens 101-105 18762411-3 2008 In the present study, EPA inhibited pro-inflammatory cytokine IL-6 production, a characteristic of certain neurodegenerative disorders, in IL-1beta-stimulated C6 glioma cells in dose-dependent fashion. Eicosapentaenoic Acid 22-25 interleukin 6 Homo sapiens 62-66 18762411-4 2008 EPA down-regulated the expression of IL-6 at mRNA level, indicating that the effect of EPA occurs at the transcriptional level. Eicosapentaenoic Acid 0-3 interleukin 6 Homo sapiens 37-41 18762411-4 2008 EPA down-regulated the expression of IL-6 at mRNA level, indicating that the effect of EPA occurs at the transcriptional level. Eicosapentaenoic Acid 87-90 interleukin 6 Homo sapiens 37-41 18762411-5 2008 In addition, peroxisome proliferator-activated receptor (PPAR) gamma antagonists abolished the inhibitory effect of EPA on IL-1beta-induced IL-6 production, whereas PPARalpha antagonist did not block the inhibitory effect of EPA. Eicosapentaenoic Acid 116-119 interleukin 6 Homo sapiens 140-144 18484740-10 2008 IL-6 but not IL-1beta determinations were lower in both saline and phosphate-buffered saline as compared to vaginal fluid matrix, with no significant effect of pH. Phosphate-Buffered Saline 67-92 interleukin 6 Homo sapiens 0-4 18308843-0 2008 Thyroid-stimulating hormone induces interleukin-6 release from human adipocytes through activation of the nuclear factor-kappaB pathway. Thyrotropin 0-27 interleukin 6 Homo sapiens 36-49 18308843-1 2008 Our objective was to identify the signaling pathway activated by TSH that induces IL-6 secretion from human abdominal sc differentiated adipocytes. Thyrotropin 65-68 interleukin 6 Homo sapiens 82-86 18308843-3 2008 IL-6 release stimulated by TSH was inhibited by 35% (P < 0.05) with SN50, an inhibitor of nuclear factor-kappaB (NF-kappaB) nuclear translocation, and 60% (P < 0.01) with sc-514, an inhibitor of inhibitory-kappaB (IkappaB) kinase (IKK)-beta. Thyrotropin 27-30 interleukin 6 Homo sapiens 0-4 18308843-8 2008 Our data demonstrate that the IKKbeta/NF-kappaB pathway is a novel TSH target that is required for TSH-induced IL-6 release from human adipocytes. Thyrotropin 67-70 interleukin 6 Homo sapiens 111-115 18308843-8 2008 Our data demonstrate that the IKKbeta/NF-kappaB pathway is a novel TSH target that is required for TSH-induced IL-6 release from human adipocytes. Thyrotropin 99-102 interleukin 6 Homo sapiens 111-115 17729256-8 2008 The amounts of interleukin-6 and interleukin-8 proinflammatory cytokines released from human blood leukocytes exposed to the polyurethane scaffolds in vitro were comparable and/or lower than the amount of the cytokines released by leukocytes exposed to the culture-grade polystyrene control. Polyurethanes 125-137 interleukin 6 Homo sapiens 15-28 18400717-7 2008 RESULTS: In Caco-2 cells, IL-6 secretion was significantly decreased by troglitazone, DHA, EPA, and GLA. Eicosapentaenoic Acid 91-94 interleukin 6 Homo sapiens 26-30 18572770-2 2008 The addition of azoximer injections to basic treatment of chronic prostatitis improves or normalizes the majority of abnormal parameters of immune and cytokine status except neutrophil phagocyte activity, IL-1beta concentration in the blood serum, IL-6 and IL-1beta concentration in prostatic gland secretion. azoximer 16-24 interleukin 6 Homo sapiens 248-252 17618502-5 2008 TiAlV particles were the most stimulatory, causing 5- to 900-fold higher cytokine expression compared with nonstimulated cells and uniquely eliciting high levels of IL-1alpha, IL-6, IL-10, and GM-CSF. tialv 0-5 interleukin 6 Homo sapiens 176-180 18314454-2 2008 Our objective was to determine whether serum protein carbonyls, an indicator of oxidative protein damage and oxidative stress, were associated with IL-6. carbonyls 53-62 interleukin 6 Homo sapiens 148-152 18203325-2 2008 We have also reported that a certain pharmacological concentration of simvastatin, i.e., 0.05-0.1 microM, inhibits the production of interleukin 6 (IL-6) and IL-8 and the cell proliferation induced by tumor necrosis factor-alpha (TNF-alpha) in fibroblast-like synoviocytes (FLS) derived from patients with RA in vitro. Simvastatin 70-81 interleukin 6 Homo sapiens 133-146 18203325-2 2008 We have also reported that a certain pharmacological concentration of simvastatin, i.e., 0.05-0.1 microM, inhibits the production of interleukin 6 (IL-6) and IL-8 and the cell proliferation induced by tumor necrosis factor-alpha (TNF-alpha) in fibroblast-like synoviocytes (FLS) derived from patients with RA in vitro. Simvastatin 70-81 interleukin 6 Homo sapiens 148-152 25795558-7 2015 Furthermore, PA induced a robust neutral sphingomyelinase (nSMase)-mediated sphingomyelin hydrolysis that was involved in PA-augmented IL-6 upregulation. Sphingomyelins 41-54 interleukin 6 Homo sapiens 135-139 24862236-4 2015 The present study has evaluated the effect of 1 microM arsenite [As(III)], 0.1 microM MMA(III) and 1 microM DMA(III) upon the release of cytokines [interleukin-6 (IL6), IL8, tumor necrosis factor alpha (TNFalpha)], using a compartmentalized co-culture model with differentiated Caco-2 cells in the apical compartment and peripheral blood mononuclear cells in the basolateral compartment. arsenite 55-63 interleukin 6 Homo sapiens 148-161 25045829-6 2015 Increased serum level of IL-6, IFN-gamma and TNF-alpha was correlated with total bilirubin, ALT, PTA and MELD scores in ACHBLF. Bilirubin 81-90 interleukin 6 Homo sapiens 25-29 25901198-1 2015 We recently described the synthesis and characterization of a novel difluorinatedbenzylidene analog of curcumin, commonly referred as CDF, which demonstrated significantly enhanced bioavailability and in vivo anticancer activity. difluorinatedbenzylidene 68-92 interleukin 6 Homo sapiens 134-137 25189464-6 2015 Our results showed that kaempferol at concentrations of 12.5 and 25 mug/mL significantly suppressed the release of TNF-alpha, IL-1beta, IL-6, and IL-18 and inhibited activation of NF-kappaB and Akt in LPS plus ATP-induced cardiac fibroblasts. kaempferol 24-34 interleukin 6 Homo sapiens 136-140 25256809-8 2015 T-cell receptor (TCR) activation of PBMCs and nickel (Ni(2+) ) treatments of human dermal microvascular endothelial cells (HDMECs) were performed resulting in IL-4, IL-6, IL-8 and IL-17 production. Nickel 46-52 interleukin 6 Homo sapiens 165-169 25256809-11 2015 Similarly, TSC inhibits overproduction of IL-4 and IL-17 in T-cell receptor (TCR)-activated PBMCs as well as nickel induction of IL-6 and IL-8 in HDMECs. Nickel 109-115 interleukin 6 Homo sapiens 129-133 25453750-7 2015 In univariate models, log transformed 25-OHD was significantly and inversely associated with log transformed IL-1beta (p=0.002) and log transformed IL-6 (p=0.032). 25-ohd 38-44 interleukin 6 Homo sapiens 148-152 25433806-7 2015 Furthermore, the inhibition of PCA on LPS-induced IL-6 and IL-8 production can be reversed by PPAR-gamma antagonist GW9662. 2-chloro-5-nitrobenzanilide 116-122 interleukin 6 Homo sapiens 50-54 25815436-4 2015 This effect was consistent when JAK2/STAT3 signaling was activated by interleukin-6 (IL-6), and ameliorated when cells were treated with prevanadate, a protein tyrosin phosphatase inhibitor. prevanadate 137-148 interleukin 6 Homo sapiens 85-89 24880451-4 2015 RESULTS: standards curves generated with the use of phosphate-buffered saline (PBS) demonstrated best adjustment for cytokines IL-1ss, IL-6 and TNF- alpha levels, when using Tris-HCl (p<0.05). Phosphate-Buffered Saline 52-77 interleukin 6 Homo sapiens 135-139 24880451-4 2015 RESULTS: standards curves generated with the use of phosphate-buffered saline (PBS) demonstrated best adjustment for cytokines IL-1ss, IL-6 and TNF- alpha levels, when using Tris-HCl (p<0.05). pbs 79-82 interleukin 6 Homo sapiens 135-139 25670984-10 2014 The production of IL-6 by LPS-activated moDC was also reduced significantly when eicosapentaenic acid was added as a RAMEA complex as compared to its DMSO-solubilized form or to the other two n-3 fatty acids either complexed or not. eicosapentaenic acid 81-101 interleukin 6 Homo sapiens 18-22 25092526-8 2014 RESULTS: Mannan, beta-glucans (curdlan), chitosan, and zymosan induced the secretion of interleukin (IL)-1beta, IL-6, IL-23, IL-10, and tumor necrosis factor-alpha by PBMCs. Chitosan 41-49 interleukin 6 Homo sapiens 112-116 25283329-10 2014 Myriocin or fumonisin B1 significantly lowered these cytokine levels and suppressed the gene expression of TNF-alpha and MCP-1 in RAW and of IL-6 and MCP-1 in L1. thermozymocidin 0-8 interleukin 6 Homo sapiens 141-145 25326656-7 2014 We will focus on one resolution mediator, protectin DX (PDX), which was recently shown to act as a muscle interleukin-6 secretagogue. 10,17-dihydroxydocosa-4,7,11,13,15,19-hexaenoic acid 56-59 interleukin 6 Homo sapiens 106-119 25288184-5 2014 Synthetic modifications of the quinazoline scaffold at the 2 and 4 positions revealed trends in structure-activity relationships with respect to TLR dependent production of the NF-kappaB associated cytokine IL-8 in human peripheral blood mononuclear cells, as well as IL-6 in mouse antigen presenting cells. Quinazolines 31-42 interleukin 6 Homo sapiens 268-272 25442884-14 2014 Co-incubation of hyaluronan and histones caused formation of histone aggregates, decreased the cytotoxic effects of the histones, and blocked the increase in IL-6 (P<.01). Hyaluronic Acid 17-27 interleukin 6 Homo sapiens 158-162 25335166-9 2014 Plasma IL-6 was significantly and positively correlated with extraversion as well as the KSP subscales impulsivity and monotony avoidance. [(1R,2S)-2-(2-hydroxybenzene-1-carbonyl)cyclopentyl]acetic acid 89-92 interleukin 6 Homo sapiens 7-11 24844601-5 2014 In addition, ZSTK474 inhibited the expression of dendritic cell-derived Th1 and Th17 cells polarizing cytokines interferon-gamma/interleukin (IL)-12 and IL-6/IL-23. ZSTK474 13-20 interleukin 6 Homo sapiens 153-157 25238390-8 2014 In human fetal membranes and myometrium, nobiletin significantly decreased LPS-stimulated expression of pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6 and IL-8) and MMP-9 expression and pro-MMP-9 secretion. nobiletin 41-50 interleukin 6 Homo sapiens 153-157 24830761-9 2014 Significant inverse associations were reported between IL-6, TNF-alpha, and IFN-gamma levels and quartiles of total reported carotenoid intake (P = .006, P = .04, and P = .04, respectively). Carotenoids 125-135 interleukin 6 Homo sapiens 55-59 25158706-9 2014 Interleukin-6-neutralizing antibody sufficiently reversed the antimelanogenic effects of adipose-derived stem cell-conditioned medium such that human epidermal melanocyte proliferation, melanin content, tyrosinase activity, and tyrosinase mRNA levels were restored (p < 0.05). Melanins 186-193 interleukin 6 Homo sapiens 0-13 24793913-4 2014 Ecto-nucleotidase (apyrase), a non-selective antagonist of P2Y receptors (suramin), and a selective P2Y11 receptor antagonist (NF157) all inhibited IL-6 production. Suramin 74-81 interleukin 6 Homo sapiens 148-152 24793913-8 2014 In conclusion, these data demonstrate that P2Y11 receptor also mediates SNP30-induced IL-6 production in human keratinocytes, confirming that the ATP-P2Y11 purinergic signaling is a common pathway of IL-6 production leading to induction of skin inflammatory diseases. snp30 72-77 interleukin 6 Homo sapiens 86-90 24793913-8 2014 In conclusion, these data demonstrate that P2Y11 receptor also mediates SNP30-induced IL-6 production in human keratinocytes, confirming that the ATP-P2Y11 purinergic signaling is a common pathway of IL-6 production leading to induction of skin inflammatory diseases. snp30 72-77 interleukin 6 Homo sapiens 200-204 24909480-0 2014 The relationship between serum bilirubin level with interleukin-6, interleukin-10 and mortality scores in patients with sepsis. Bilirubin 31-40 interleukin 6 Homo sapiens 52-65 24962480-10 2014 Oligonol intake attenuated elevations in IL-1beta (an 11.1-fold change vs. a 13.9-fold change immediately after heating; a 12.0-fold change vs. a 12.6-fold change 1h after heating) and IL-6 (an 8.6-fold change vs. a 9.9-fold change immediately after heating; a 9.1-fold change vs. a 10.5-fold change 1h after heating) immediately and 1 h after heating in comparison to those in the placebo group. oligonol 0-8 interleukin 6 Homo sapiens 185-189 24971305-10 2014 Among patients with elevated C-reactive protein concentrations, levels of both interleukin-6 (IL-6) and IL-10 decreased at 24 h of aminophylline therapy. Aminophylline 131-144 interleukin 6 Homo sapiens 79-92 24971305-10 2014 Among patients with elevated C-reactive protein concentrations, levels of both interleukin-6 (IL-6) and IL-10 decreased at 24 h of aminophylline therapy. Aminophylline 131-144 interleukin 6 Homo sapiens 94-98 24661543-2 2014 Increases in lipolysis and in expression and release of interleukin-6 (IL-6) occur in TSH-stimulated adipocytes, and levels of circulating free fatty acids and IL-6 rise following TSH administration to patients with previous thyroidectomy and radioablation for thyroid cancer. Thyrotropin 86-89 interleukin 6 Homo sapiens 56-69 24661543-2 2014 Increases in lipolysis and in expression and release of interleukin-6 (IL-6) occur in TSH-stimulated adipocytes, and levels of circulating free fatty acids and IL-6 rise following TSH administration to patients with previous thyroidectomy and radioablation for thyroid cancer. Thyrotropin 86-89 interleukin 6 Homo sapiens 71-75 24661543-2 2014 Increases in lipolysis and in expression and release of interleukin-6 (IL-6) occur in TSH-stimulated adipocytes, and levels of circulating free fatty acids and IL-6 rise following TSH administration to patients with previous thyroidectomy and radioablation for thyroid cancer. Thyrotropin 180-183 interleukin 6 Homo sapiens 160-164 24720974-0 2014 A competitive electrochemical immunosensor for the detection of human interleukin-6 based on the electrically heated carbon electrode and silver nanoparticles functionalized labels. Silver 138-144 interleukin 6 Homo sapiens 70-83 24720974-2 2014 A novel competitive electrochemical immunosensor was then proposed by combining the ERGO-AuPdNPs platform with silver nanoparticles (AgNPs) functionalized polystyrene bionanolabel for the sensitive detection of human interleukin-6 (IL-6). Silver 111-117 interleukin 6 Homo sapiens 217-230 24446657-5 2014 When activated by TSH, they produce IL-6, IL-8, and TNF-alpha. Thyrotropin 18-21 interleukin 6 Homo sapiens 36-40 24499049-4 2014 Ni(II)-NTA-DG and the formed polyplexes induced an activation of iDCs, showing an increasing expression of costimulatory molecules CD86, CD80, and proinflammatory cytokines IL-6 and IL-8. ni(ii)-nta-dg 0-13 interleukin 6 Homo sapiens 173-177 24502806-12 2014 In vitro assays revealed that TMP inhibited NF-kappaB translocation and its downstream production of inflammatory factors, such as TNF-alpha, IL-6 and IL-8, and that ROS production that was induced by LPS in Caco-2 cells. tetramethylpyrazine 30-33 interleukin 6 Homo sapiens 142-146 24583784-0 2014 Three new lignan glycosides with IL-6 inhibitory activity from Akebia quinata. lignan glycosides 10-27 interleukin 6 Homo sapiens 33-37 24416783-8 2014 TNF-alpha, IL-6 and IFN-gamma had significant positive correlation with viral load, serum bilirubin and prothrombin time in pregnant women. Bilirubin 90-99 interleukin 6 Homo sapiens 11-15 24802951-1 2014 The aim of this study was to determine whether the highest vitamin C supplementation associated with complete bioavailability influences the plasma and blood mononuclear cell IL-6 and IL-10 response to exercise. Ascorbic Acid 59-68 interleukin 6 Homo sapiens 175-179 25253919-10 2014 Vitamin C significantly decreased ROS, DNA damage, TNF-alpha, and IL-6. Ascorbic Acid 0-9 interleukin 6 Homo sapiens 66-70 24149444-7 2013 Intakes of beta-carotene equivalents and vitamin C were associated with adiponectin; saturated fatty acids (SFA), vitamin A, manganese and selenium with leptin; linoleic acid with PAI-1; and oleic acid and vitamin E with IL-6. Ascorbic Acid 41-50 interleukin 6 Homo sapiens 221-225 23916117-7 2013 In cancer NAF samples (containing higher amounts of aluminium salts) we also found a significantly increased levels of pro-inflammatory cytokines (IL-1beta, IL-6, IL-12 p70, and TNF-alpha) and chemoattractant CC and CXC chemokines (IL-8, MIP-1alpha and MCP-1). aluminium salts 52-67 interleukin 6 Homo sapiens 157-161 23811328-4 2013 The results showed that, on acute or chronic exposure to arsenite, HBE cells over-expressed the pro-inflammatory cytokines, interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-1beta (IL-1beta). arsenite 57-65 interleukin 6 Homo sapiens 124-137 23811328-4 2013 The results showed that, on acute or chronic exposure to arsenite, HBE cells over-expressed the pro-inflammatory cytokines, interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-1beta (IL-1beta). arsenite 57-65 interleukin 6 Homo sapiens 139-143 23811328-6 2013 Moreover, IL-6 and IL-8 were essential for the malignant progression of arsenite-transformed HBE cells. arsenite 72-80 interleukin 6 Homo sapiens 10-14 24122998-8 2013 CONCLUSION: EPA inhibits NF-kappaB activation and IL-6 production in oesophageal cancer cells, their inducing apoptosis. Eicosapentaenoic Acid 12-15 interleukin 6 Homo sapiens 50-54 23817641-5 2013 Higher (p < 0.05) concentrations of IL-6, IL-17 and MCP-1 were found in lipopolysaccharide-stimulated PBMC from RA patients compared to controls. PBMC 105-109 interleukin 6 Homo sapiens 39-43 23752063-11 2013 IL-6 was significantly correlated only with TBUT (R = -0.38, P = .02) in the non-SS group. tbut 44-48 interleukin 6 Homo sapiens 0-4 23649946-5 2013 We review studies showing a relationship between elevated aqueous VEGF, monocyte chemoattractant protein -1, interleukin 6, or interleukin 8 in association with DME and as predictors of DME. dme 161-164 interleukin 6 Homo sapiens 109-122 23904362-6 2013 The results showed that Sal significantly decreased the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX2), interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) at both mRNA and protein levels in THP-1-derived macrophages, and the effect was dose-depedent. rhodioloside 24-27 interleukin 6 Homo sapiens 165-178 23904362-6 2013 The results showed that Sal significantly decreased the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX2), interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) at both mRNA and protein levels in THP-1-derived macrophages, and the effect was dose-depedent. rhodioloside 24-27 interleukin 6 Homo sapiens 180-184 23904362-8 2013 The findings suggested that Sal can suppress the activation of LPS-stimulated PMA-differetiated THP-1 cells, as evidenced by the decreased expression of iNOS, COX2, IL-1beta, IL-6 and TNF-alpha, and the mechanism involves the inhibition of NF-kappaB activation and the phosphorylation of the MAPK signal pathway. rhodioloside 28-31 interleukin 6 Homo sapiens 175-179 23706224-1 2013 Chitosan-silica/CpG oligodeoxynucleotide (ODN) nanohybrids were synthesized to stimulate Toll-like receptor 9-mediated induction of interleukin-6 (IL-6). Chitosan 0-8 interleukin 6 Homo sapiens 132-145 23706224-1 2013 Chitosan-silica/CpG oligodeoxynucleotide (ODN) nanohybrids were synthesized to stimulate Toll-like receptor 9-mediated induction of interleukin-6 (IL-6). Chitosan 0-8 interleukin 6 Homo sapiens 147-151 23861862-7 2013 SIGNIFICANCE: Serum amyloid A as a major protein involved in the acute and chronic stages of inflammation, and IL-6 and bFGF were significantly associated with the extent of macular edema in patients with RVO. rvo 205-208 interleukin 6 Homo sapiens 111-115 23742030-12 2013 Microdialysis levels of histamine, IL-6 and IL-8 assessed 1-3 h after cold challenge were significantly (P < 0.05) decreased following up-dosing with 80 mg bilastine. bilastine 159-168 interleukin 6 Homo sapiens 35-39 22901987-3 2013 The main finding was that "in vitro" exposure to p,p"-DDE enhanced the expression of proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) at the protein level in PBMCs. Dichlorodiphenyl Dichloroethylene 49-57 interleukin 6 Homo sapiens 133-137 23624712-13 2013 These results suggest that BBD9 induces apoptosis in MM cells through the inhibition of the IL-6 signaling pathway, leading to FOXO3a activation and upregulation of pro-apoptotic Bim. bbd9 27-31 interleukin 6 Homo sapiens 92-96 23538743-7 2013 IL-6 level showed correlation with LV mean e" (r = -0.57, P = 0.001), E/e" (r = 0.55, P = 0.001) and NT-proBNP (r = 0.52, P = 0.003). nt-probnp 101-110 interleukin 6 Homo sapiens 0-4 32260983-9 2013 The expression levels of IL-6 and COX-2 were reduced dramatically when increasing the proportion of Mg80-OLA20 from 0 to 50 wt%. mg80-ola20 100-110 interleukin 6 Homo sapiens 25-29 22415765-11 2013 Specifically, needle- and plate-shaped nHA induced the most significant cell-specific cytotoxicity and IL-6 expression but showed the least particle-cell association. nha 39-42 interleukin 6 Homo sapiens 103-107 23771657-8 2013 Moreover, IL-6 enhanced the activation of the JAK2/STAT3 signalling pathway and therefore attenuated the germacrone-induced apoptosis. germacrone 105-115 interleukin 6 Homo sapiens 10-14 23574727-7 2013 Amongst the EF and pro-inflammatory biomarkers, sevelamer carbonate decreased serum endothelin-1, plasminogen activator inhibitor-1, C-reactive protein and interleukin-6. Sevelamer 48-67 interleukin 6 Homo sapiens 156-169 22915623-14 2013 Finally, simvastatin had an additive effect with infliximab to decrease the effect of the combination of IL-17 and TNF-alpha on IL-6 mRNA expression. Simvastatin 9-20 interleukin 6 Homo sapiens 128-132 23159435-4 2013 RESULTS: Simvastatin, but not placebo, reduced monocyte release of tumor necrosis factor-alpha, interleukin-6, interleukin-1beta and monocyte chemoattractant protein-1, as well decreased plasma levels of C-reactive protein. Simvastatin 9-20 interleukin 6 Homo sapiens 96-109 23331562-8 2013 The enhancing effects of simvastatin on FP effects were mediated through the up-regulation of indoleamine 2, 3-dioxygenase and interleukin (IL)-10, together with down-regulation of IL-6 and IL-23 expression in mDCs. Simvastatin 25-36 interleukin 6 Homo sapiens 181-185 23333629-3 2013 In the study, taraxerol concentration dependently inhibited nitric-oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) at the protein and mRNA levels and these inhibitions decreased the production of nitric oxide (NO), prostaglandin 2 (PGE2), tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, and IL-1beta induced by LPS. taraxerol 14-23 interleukin 6 Homo sapiens 283-301 23533494-8 2013 Resveratrol significantly decreased CSC-related Shh expression, Gli-1 nuclear translocation, and cell viability in IL-6-treated HL-60 cells and had synergistic effect with Shh inhibitor cyclopamine on inhibiting cell growth. cyclopamine 186-197 interleukin 6 Homo sapiens 115-119 24302816-7 2013 Furthermore, both NF- kappa B inhibitor Bay11-7085 and p38 inhibitor SB203580 significantly suppressed the enhanced production of IL-6 and MMPs induced by HMGB1-LPS. BAY 11-7085 40-50 interleukin 6 Homo sapiens 130-134 23840918-7 2013 Luteolin and kaempferol significantly reduced LPS-induced secretion of proinflammatory cytokines (IL-6 and IL-8) and prostaglandins (PGE(2) and PGF(2alpha)) in fetal membranes, IL-1beta-induced COX-2 gene expression and prostaglandin production in myometrium, and IL-1beta-induced MMP-9 activity in amnion and myometrial cells. kaempferol 13-23 interleukin 6 Homo sapiens 98-102 23206933-9 2012 Adding IL-6 increased GAG production by healthy chondrocytes and decreased GAG release by osteoarthritic chondrocytes (P < 0.05). Glycosaminoglycans 22-25 interleukin 6 Homo sapiens 7-11 23206933-9 2012 Adding IL-6 increased GAG production by healthy chondrocytes and decreased GAG release by osteoarthritic chondrocytes (P < 0.05). Glycosaminoglycans 75-78 interleukin 6 Homo sapiens 7-11 23206933-10 2012 Inhibition of IL-6 present in osteoarthritic synovial fluid showed a trend towards decreased GAG content of the explants (P = 0.06). Glycosaminoglycans 93-96 interleukin 6 Homo sapiens 14-18 22475809-6 2012 Moreover, IL-6 and MCP-1 were more significantly reduced by EPA treatment compared to Agt (IL-6>MCP>Agt). Eicosapentaenoic Acid 60-63 interleukin 6 Homo sapiens 10-14 22475809-6 2012 Moreover, IL-6 and MCP-1 were more significantly reduced by EPA treatment compared to Agt (IL-6>MCP>Agt). Eicosapentaenoic Acid 60-63 interleukin 6 Homo sapiens 91-95 22375890-1 2012 OBJECTIVE: This study aimed to determine the effects of a monounsaturated fatty acids (MUFA)-rich diet on serum visfatin, interleukin-6 and insulin levels among overweight women. Fatty Acids, Monounsaturated 58-85 interleukin 6 Homo sapiens 122-135 22848036-3 2012 The levels of IL-6 in the new CPS group (CAPSEAL I, II) were higher than those in the control and all experimental groups at all time points after 2 h. TGF-beta1 and FGF-1 levels decreased at 72 h compared to the levels in the control, in cells treated with every sealers except ARS I. capseal II 30-33 interleukin 6 Homo sapiens 14-18 22305406-7 2012 Furthermore, EPA inhibited TNF-alpha-mediated transcription and secretion of interleukin (IL)-6, a key target gene of TNF-mediated NF-kappaB transcriptional activity. Eicosapentaenoic Acid 13-16 interleukin 6 Homo sapiens 77-95 22983415-6 2012 On day 1, median IL-6 level was significantly lower in FUO group compared with CDI+MDI groups combined (P < 0.001). 1,1'-Carbonyldiimidazole 79-82 interleukin 6 Homo sapiens 17-21 22365613-2 2012 Vitamin E and the carotenoids are two classes of dietary antioxidants with profound anti-inflammatory effects, and the goal of this study was to assess whether higher post-fracture concentrations of these antioxidants were associated with lower levels of interleukin 6 (IL-6) and the soluble receptor for tumor necrosis factor-alpha (sTNF-alphaR1), two common markers of inflammation. Carotenoids 18-29 interleukin 6 Homo sapiens 255-268 22299617-7 2012 However, whereas DHA reduced only the high IL-1beta/IL-10 ratio, EPA was able to reduce also the IL-6/IL-10 ratio. Eicosapentaenoic Acid 65-68 interleukin 6 Homo sapiens 97-101 22762853-8 2012 GA-Me down-regulated the expression of various NF-kappaB-regulated genes including genes involved in cell proliferation (c-Myc and cyclin D1), anti-apoptosis (Bcl-2), invasion (MMP-9) and angiogenesis (VEGF, interleukin (IL)-6 and -8). ganoderic acid Me 0-5 interleukin 6 Homo sapiens 208-233 22687715-6 2012 In addition, IL-8 and IL-6 levels were significantly higher in culture supernatants of A549 cells that were incubated with formaldehyde-fixed P. brasiliensis compared to cultures of cells that were infected with live yeasts. Formaldehyde 123-135 interleukin 6 Homo sapiens 22-26 22789904-6 2012 Intrastriatal administration of 6-OHDA (20 mug; 4 mul of 5 mug/mul) significantly caused impairment in body weight, locomotor activity, rota-rod performance, oxidative defense and mitochondrial enzyme complex activity, and increase in the inflammatory cytokine levels (TNF-alpha and IL-6) as compared to naive animals. Oxidopamine 32-38 interleukin 6 Homo sapiens 283-287 22841385-7 2012 Exposure of mdDC to purified CarLA resulted in the increased production of the pro-inflammatory cytokines IL-6 and to a lesser extent of IL-8 and TNF-alpha, and a reduced production of the anti-inflammatory cytokine IL-1RA. mddc 12-16 interleukin 6 Homo sapiens 106-110 22213519-10 2012 The altered association between interleukin-6 and sex steroids is possibly involved in ADT-related lipid metabolism disorder with unchanged interleukin-6 levels despite increased %body fat. adt 87-90 interleukin 6 Homo sapiens 32-45 22213519-10 2012 The altered association between interleukin-6 and sex steroids is possibly involved in ADT-related lipid metabolism disorder with unchanged interleukin-6 levels despite increased %body fat. adt 87-90 interleukin 6 Homo sapiens 140-153 24049649-6 2012 Furthermore, calcium ionophore (A23187), which upregulates DUOX and NOX2 activities, strongly induced oxidative stress and IL-8 and IL-6 overexpression in IB3-1 cells. Calcimycin 32-38 interleukin 6 Homo sapiens 132-136 22894740-0 2012 High doses of in vitro beta-carotene, alpha-tocopherol and ascorbic acid induce oxidative stress and secretion of IL-6 in peripheral blood mononuclear cells from healthy donors. alpha-Tocopherol 38-54 interleukin 6 Homo sapiens 114-118 22894740-0 2012 High doses of in vitro beta-carotene, alpha-tocopherol and ascorbic acid induce oxidative stress and secretion of IL-6 in peripheral blood mononuclear cells from healthy donors. Ascorbic Acid 59-72 interleukin 6 Homo sapiens 114-118 22572643-8 2012 The ability of alpha-tocopherol to affect IL-6 production was influenced by the GSTP1 313 polymorphism (P = 0.019). alpha-Tocopherol 15-31 interleukin 6 Homo sapiens 42-46 22421411-8 2012 IL-6 slightly enhanced the sensitivity of RPMI-8226 cells to erufosine, thus emphasizing the heterogeneity of MM. erucylphospho-N,N,N-trimethylpropylammonium 61-70 interleukin 6 Homo sapiens 0-4 22421411-10 2012 In all cases of IL-6- or OPN-induced resistance, the effective concentrations of erufosine were still within the clinically achievable range. erucylphospho-N,N,N-trimethylpropylammonium 81-90 interleukin 6 Homo sapiens 16-21 22607552-13 2012 Pericytes exposed to SBCMV elicited higher levels of IL-6 compared to both mock-infected as well as heat-killed virus controls. sbcmv 21-26 interleukin 6 Homo sapiens 53-57 22360661-0 2012 Configurational reassignment and improved preparation of the competitive IL-6 receptor antagonist 20R,21R-epoxyresibufogenin-3-formate. 21r-epoxyresibufogenin-3-formate 102-134 interleukin 6 Homo sapiens 73-77 21487705-7 2012 Serum IL-6 levels positively correlated with age, waist-hip ratio (WHR), systolic blood pressure, circulating levels of TNF-alpha, IL-1beta, and ox-LDL, and urinary 8-epi-prostaglandin F(2)alpha. 8-epi-prostaglandin f 165-186 interleukin 6 Homo sapiens 6-10 22388612-5 2012 RESULTS: Regarding inflammation, 25-hydroxyvitamin D inversely correlated with both CRP and IL-6. 25-hydroxyvitamin D 33-52 interleukin 6 Homo sapiens 92-96 21161531-6 2012 Furthermore, IL-6 and IL-8 expression was quantified by real-time polymerase chain reaction (RT-PCR) and ELISAs from cells which were exposed to SB203580, U0126 and NaHS and stimulated by IL-1beta. SODIUM HYDROSULFIDE 165-169 interleukin 6 Homo sapiens 13-17 21161531-8 2012 The data provided prove that in these cells, constitutive as well as IL-1beta-induced IL-6 and IL-8 expression was partially and transiently blocked by the treatment of cells with both MAPK inhibitors and NaHS. SODIUM HYDROSULFIDE 205-209 interleukin 6 Homo sapiens 86-90 22611924-6 2012 CONCLUSION: The expression of NF-kappaB, MCP-1, IL-1beta, IL-6 and IL-8 in HUVECs up-regulated by TNF-alpha was promoted by CIT. citreoviridin 124-127 interleukin 6 Homo sapiens 58-62 21809384-6 2012 Short exposure to IL-1alpha, IL-6, or IL-8 decreased endogenous GTP-Cdc42 and increased stress fibers, which were reversed with cytochalasin D treatment. Cytochalasin D 128-142 interleukin 6 Homo sapiens 29-33 22293241-4 2012 The present study aimed to investigate the acute and chronic effects of a 2 x 180 mg per day dose of eicosapentaenoic acid (EPA) on interleukin-6 (IL-6) mediated inflammatory response and symptoms associated with DOMS. Eicosapentaenoic Acid 101-122 interleukin 6 Homo sapiens 132-145 22293241-4 2012 The present study aimed to investigate the acute and chronic effects of a 2 x 180 mg per day dose of eicosapentaenoic acid (EPA) on interleukin-6 (IL-6) mediated inflammatory response and symptoms associated with DOMS. Eicosapentaenoic Acid 101-122 interleukin 6 Homo sapiens 147-151 22293241-4 2012 The present study aimed to investigate the acute and chronic effects of a 2 x 180 mg per day dose of eicosapentaenoic acid (EPA) on interleukin-6 (IL-6) mediated inflammatory response and symptoms associated with DOMS. Eicosapentaenoic Acid 124-127 interleukin 6 Homo sapiens 132-145 22293241-4 2012 The present study aimed to investigate the acute and chronic effects of a 2 x 180 mg per day dose of eicosapentaenoic acid (EPA) on interleukin-6 (IL-6) mediated inflammatory response and symptoms associated with DOMS. Eicosapentaenoic Acid 124-127 interleukin 6 Homo sapiens 147-151 22293241-8 2012 In fact, relative to the first baseline, by the third bout of eccentric workout, the EPA group had 103 +- 60% increment in IL-6 levels whereas the placebo group only had 80 +- 26% incremented IL-6 levels (P = 0.020). Eicosapentaenoic Acid 85-88 interleukin 6 Homo sapiens 123-127 22293241-8 2012 In fact, relative to the first baseline, by the third bout of eccentric workout, the EPA group had 103 +- 60% increment in IL-6 levels whereas the placebo group only had 80 +- 26% incremented IL-6 levels (P = 0.020). Eicosapentaenoic Acid 85-88 interleukin 6 Homo sapiens 192-196 23383400-9 2012 Finally, sALS patients had significantly higher concentrations of IL6, sIL6R and C-reactive protein in the cerebrospinal fluid when compared to AD patients. sals 9-13 interleukin 6 Homo sapiens 66-69 22132896-13 2012 Finally, inflammatory cytokines, such as tumour necrosis factor (TNF)-alpha and interleukin (IL)-6, showed lower levels in the graft of those animals that had been pretreated with rapamycin or tacrolimus. Tacrolimus 193-203 interleukin 6 Homo sapiens 80-98 22153537-8 2012 PAI-1 and IL-6 were significantly correlated with mean arterial pressure, BMI, uric acid, total and LDL-cholesterol. Uric Acid 79-88 interleukin 6 Homo sapiens 10-14 22509110-5 2012 RESULTS: The levels of IL-6 and IFN-gamma in tear fluid in ocular GvHD patients were significantly elevated in comparison to patients without ocular GvHD and healthy controls (p<0.005 for each) The levels of IFN-gamma correlated with the Schirmer score (r=-0.48, p<0.0001) and tear break up time (TBUT; r=-0.38, p=0.03). tbut 303-307 interleukin 6 Homo sapiens 23-27 20678906-10 2012 Both crude and lipid-adjusted carotenoids were inversely correlated with CRP and IL-6 in plasma but the change in carotenoid status during simvastatin therapy was not specifically related to any changes in inflammatory markers. Carotenoids 30-41 interleukin 6 Homo sapiens 81-85 20678906-10 2012 Both crude and lipid-adjusted carotenoids were inversely correlated with CRP and IL-6 in plasma but the change in carotenoid status during simvastatin therapy was not specifically related to any changes in inflammatory markers. Carotenoids 30-40 interleukin 6 Homo sapiens 81-85 22347395-10 2012 CONCLUSION: This study established the face validity of IL-6 measurement by MSD, R&D, and ULX but not LX, and the superiority of MSD with respect to dynamic range. lx 95-97 interleukin 6 Homo sapiens 56-60 21945492-9 2011 Daidzein also suppressed pro-inflammatory cytokine production such as IL-12p40, IL-6 and TNF-alpha, whereas it didn"t affect IL-10 and IL-1beta expression. daidzein 0-8 interleukin 6 Homo sapiens 80-84 22152804-4 2011 Furthermore, whether TLR4 inhibitor, TAK-242, could interrupt the expression of TRIF as well as some inflammatory cytokines such as IL-6, IL-8 and TNF-alpha in THP-1 cells stimulated with beta2 GPI/anti-beta2 GPI complex was also investigated. ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate 37-44 interleukin 6 Homo sapiens 132-136 21946433-4 2011 Monosodium urate crystals were able to significantly increase the release of the inflammatory cytokine IL-6, the chemokine CXCL8 and the matrix metalloproteinase (MMP)-1 from both normal and RA-FLS (all P<0.05). Uric Acid 0-16 interleukin 6 Homo sapiens 103-107 21946433-5 2011 Moreover, the additive or synergistic effect on the release of IL-6, CXCL8 and MMP-1 from both normal and RA-FLS was observed following the combined treatment with monosodium urate crystals and TNF-alpha or IL-1beta. Uric Acid 164-180 interleukin 6 Homo sapiens 63-67 21677137-6 2011 Activation of Nod1 by its agonist, bacterial gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP), in term trophoblast cultures induced a proinflammatory cytokine profile, characterized by elevated levels of secreted IL-6, GRO-alpha, and MCP-1, when compared with the control. N(2)-(gamma-D-glutamyl)-meso-2,2'-diaminopimelic acid 45-86 interleukin 6 Homo sapiens 215-219 21546388-11 2011 Treatment of ESCs with the TGF-beta type 1 inhibitor, SB431542, inhibited both TGF-beta1-stimulation of PAR2 gene expression and PAR2AP-induced IL-6 secretion. 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide 54-62 interleukin 6 Homo sapiens 144-148 21051589-9 2011 Results of reporter assays, immunoblot assays, and ELISA revealed that the heat shock protein 90 (Hsp90) inhibitors 17-allyamino-17-demethoxygeldanamycin and geldanamycin blocked IL-6-induced PSA gene expression. geldanamycin 141-153 interleukin 6 Homo sapiens 179-183 22693300-6 2011 Due to the disease severity, the failure of previous disease-modifying agents and the development of steroid related sideeffects, the authors decided to treat her with intravenous tocilizumab (TCZ;an interleukin 6 blocker). tioconazole 193-196 interleukin 6 Homo sapiens 200-213 21533553-4 2011 Exposure of HaCaT cells to CoCl(2) reduced cell viability and caused overproduction of reactive oxygen species (ROS) and oversecretion of interleukin-6 (IL-6) and interleukin-8 (IL-8). cobaltous chloride 27-34 interleukin 6 Homo sapiens 138-151 21533553-4 2011 Exposure of HaCaT cells to CoCl(2) reduced cell viability and caused overproduction of reactive oxygen species (ROS) and oversecretion of interleukin-6 (IL-6) and interleukin-8 (IL-8). cobaltous chloride 27-34 interleukin 6 Homo sapiens 153-157 21533553-6 2011 Inhibition of COX-2 by NS-398, a selective inhibitor of COX-2, significantly repressed the cytotoxicity, as well as secretion of IL-6 and IL-8 induced by CoCl(2). N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 23-29 interleukin 6 Homo sapiens 129-133 21397682-5 2011 Furthermore, the plasma PFOS concentrations (2.09-8.98 ng/ml) found in our study subjects correlated positively with the LPS-stimulated IL-6 release. perfluorooctane sulfonic acid 24-28 interleukin 6 Homo sapiens 136-140 21248083-7 2011 Patients with PIS showed significant greater changes of inflammation marker levels, including hs-CRP and IL-6, as compared with the non-PIS group. Monothiopyrophosphoric acid 14-17 interleukin 6 Homo sapiens 105-109 20158569-9 2011 Simvastatin, atorvastatin, fluvastatin or pravastatin reduced the IL-6 production by 53%, 50%, 64% and 60%, respectively. Simvastatin 0-11 interleukin 6 Homo sapiens 66-70 21186983-6 2011 These novel oligosaccharides showed strong and long-lasting stimulation of phagocytosis and significant potentiation of synthesis and/or secretion of interleukin (IL-2, IL-4, IL-5, IL-6), tumor necrosis factor-alpha, and vascular endothelial growth factor. Oligosaccharides 12-28 interleukin 6 Homo sapiens 181-185 21111811-4 2011 Treatment with GM6001, a general matrix metalloprotease inhibitor, indicated that IL-6 activates EGF-R through cleavage and release of membrane-anchored EGF-R ligands. N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide 15-21 interleukin 6 Homo sapiens 82-86 21111811-6 2011 GW280264X that targets both ADAM10 and ADAM17 blocked IL-6-induced proliferation and ERK1/2 phosphorylation with same potency as GM6001. N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide 129-135 interleukin 6 Homo sapiens 54-58 21111811-7 2011 However, ADAM10 inhibitor GI254023X and ADAM17 inhibitor TAPI-2 were less efficient in inhibiting response of RWPE-1 cells to IL-6, indicating possible cooperation of ADAM17 with ADAM10 or other metalloproteases. 3-(formylhydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid (2,2-dimethyl-1-methylcarbamoyl-1-propyl)amide 26-35 interleukin 6 Homo sapiens 126-130 20604677-4 2011 The results indicated that beta-eudesmol inhibited the production and expression of interleukin (IL)-6 on phorbol 12-myristate 13-acetate and calcium ionophore A23187-stimulated human mast cell (HMC). Calcimycin 160-166 interleukin 6 Homo sapiens 84-102 21305014-6 2011 Using calcium-flux assays, 3O-C12 was found to induce larger and more sustained increases in intracellular calcium in IB3-1 cells compared to C38, and blocking this calcium flux with BAPTA-AM reduced the production of IL-6 by IB3-1 to the levels produced by C38. 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 183-191 interleukin 6 Homo sapiens 218-222 21075133-5 2011 IL-6 release was decreased only by PFOS. perfluorooctane sulfonic acid 35-39 interleukin 6 Homo sapiens 0-4 21628878-2 2011 SA significantly inhibited phorbol myristate acetate (PMA) plus A23187-induced the production and expression of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha in human mast cell (HMC)-1 cells. Calcimycin 64-70 interleukin 6 Homo sapiens 112-130 21261439-9 2011 Further studies are required to characterize effects on inflammatory markers such as IL-6 at environmentally relevant concentrations of PFOS and to determine the key events associated with PFOS-induced IgM suppression to address potential human health risks. perfluorooctane sulfonic acid 136-140 interleukin 6 Homo sapiens 85-89 21779360-6 2011 Similar to the protective effect of H(2)S, both NS-398 (a selective COX-2 inhibitor) and PDTC (a selective NF-kappaB inhibitor) depressed not only CoCl(2)-induced cytotoxicity, but also the secretions of IL-1beta, IL-6 and IL-8. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 48-54 interleukin 6 Homo sapiens 214-218 21129557-8 2010 RESULTS: Eicosapentaenoic acid effectively reduced LPS-induced or PGE(2)-induced TNF-alpha and IL-6 expression, and increased IL-10 expression significantly when compared with arachidonic acid. Eicosapentaenoic Acid 9-30 interleukin 6 Homo sapiens 95-99 20637814-9 2010 The production of inflammatory cytokine, IL-6 from macrophages was significantly reduced by Ad/chitosan-PEG-FA nanocomplexes, implying the potential for use in systemic administration. Chitosan 95-103 interleukin 6 Homo sapiens 41-45 20451499-4 2010 Thrombin activated Akt, PKC and MAPK in HAoSMC, and thrombin-mediated expression of IL-6 and CXCL8 was significantly inhibited by LY294002, AKT IV, RO318220, and GF109203X as well as by diphenyleneiodium at the messenger RNA and the protein levels. bisindolylmaleimide I 162-171 interleukin 6 Homo sapiens 84-88 20607065-6 2010 The cortisol concentration and serum levels of IL-1beta and IL-6 after Oligonol intake were significantly decreased compared to before treatment (P < 0.01, respectively). oligonol 71-79 interleukin 6 Homo sapiens 60-64 19725895-5 2010 IBD PBMC produced more IL-6 with all the TLR agonists tested than controls. PBMC 4-8 interleukin 6 Homo sapiens 23-27 20526368-5 2010 Therefore we studied the effects of the free fatty acid palmitate and bacterial lipopolysaccharide (LPS) on interleukin-6 (IL-6) and monocyte chemotactic protein-1 (MCP-1) expression and secretion in cultured human bladder smooth muscle cells (hBSMC). free fatty acid palmitate 40-65 interleukin 6 Homo sapiens 108-121 20084046-5 2010 Interleukin 6 mRNA expression in cultured islets, as well as IL-6, IL-8, and granulocyte-macrophage colony-stimulating factor released into the medium, was significantly reduced by adding SD-282. indole-5-carboxamide 188-194 interleukin 6 Homo sapiens 0-13 20084046-5 2010 Interleukin 6 mRNA expression in cultured islets, as well as IL-6, IL-8, and granulocyte-macrophage colony-stimulating factor released into the medium, was significantly reduced by adding SD-282. indole-5-carboxamide 188-194 interleukin 6 Homo sapiens 61-65 20097190-6 2010 RESULTS: Multi-adjusted regression analyses revealed that plasma n-3 fatty acids were inversely associated with CRP, IL-6 and TNF-alpha; plasma n-6 fatty acids were inversely associated with CRP, IL-6 and fibrinogen; monounsaturated fatty acids were inversely associated with CRP and IL-6 (all p-values<0.05). Fatty Acids, Omega-6 144-159 interleukin 6 Homo sapiens 196-200 20097190-6 2010 RESULTS: Multi-adjusted regression analyses revealed that plasma n-3 fatty acids were inversely associated with CRP, IL-6 and TNF-alpha; plasma n-6 fatty acids were inversely associated with CRP, IL-6 and fibrinogen; monounsaturated fatty acids were inversely associated with CRP and IL-6 (all p-values<0.05). Fatty Acids, Omega-6 144-159 interleukin 6 Homo sapiens 196-200 20371718-5 2010 Perifosine inhibited rapamycin-induced phosphorylated Akt, resulting in enhanced cytotoxicity in MM.1S cells even in the presence of interleukin-6, insulin-like growth factor-I, or bone marrow stromal cells. perifosine 0-10 interleukin 6 Homo sapiens 133-146 20206126-4 2010 We show here that endogenous and plant-derived inhibitors of the Na(+)/K(+)-ATPase, i.e. the cardiac glycosides ouabain and digitoxin, inhibit IL-1beta- and IL-6-induced APP expression in human hepatoma cells and primary human hepatocytes (PHH) at nanomolar concentrations. Digitoxin 124-133 interleukin 6 Homo sapiens 157-161 20450730-14 2010 The CO(2) environment up-regulates the level of IL-6. co(2) 4-9 interleukin 6 Homo sapiens 48-52 20075928-6 2010 After 6 months of candesartan therapy, sICAM-1, IL-6 and Hs-CRP were significantly lower compared to baseline in both groups; furthermore, there was a significant decrease of SBP and DBP values in both groups. candesartan 18-29 interleukin 6 Homo sapiens 48-52 20022932-6 2010 COX-2 inhibition by NS-398 enhanced IL-6 and TNF-alpha expression and IL-6 protein secretion induced by palmitate. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 20-26 interleukin 6 Homo sapiens 36-40 20159692-4 2010 RESULTS: Compared with the control group, high-concentration FK506 (20 ng/ml) significantly inhibited the secretions of IL-2, IL-6, IL-12, IL-17, IFN-gamma, TNF-alpha, GM-CSF and G-CSF. Tacrolimus 61-66 interleukin 6 Homo sapiens 126-130 20065508-0 2009 IL-6 and IL-8 responses of colorectal cancer in vivo and in vitro cancer cells subjected to simvastatin. Simvastatin 92-103 interleukin 6 Homo sapiens 0-4 20065508-6 2009 Treatment of CRC with simvastatin (80 mg/day for 14 days) led to a significant decrease of serum IL-6, while the IL-8 level was less affected. Simvastatin 22-33 interleukin 6 Homo sapiens 97-101 20065508-7 2009 The in vitro experiments on colorectal cancer-derived cell lines (HT-29 and Caco-2) demonstrated that application of simvastatin decreased generation of both IL-6 and IL-8. Simvastatin 117-128 interleukin 6 Homo sapiens 158-162 20065508-9 2009 We conclude that 1) colorectal carcinogenesis is accompanied by increased synthesis and release of proinflammatory cytokines such as IL-6 and IL-8; 2) simvastatin therapy results in a decrease in serum level of proinflammatory cytokines, especially IL-6 in CRC and 3) simvastatin inhibits release of IL-8 and IL-6 from colorectal cell lines. Simvastatin 151-162 interleukin 6 Homo sapiens 133-137 20065508-9 2009 We conclude that 1) colorectal carcinogenesis is accompanied by increased synthesis and release of proinflammatory cytokines such as IL-6 and IL-8; 2) simvastatin therapy results in a decrease in serum level of proinflammatory cytokines, especially IL-6 in CRC and 3) simvastatin inhibits release of IL-8 and IL-6 from colorectal cell lines. Simvastatin 151-162 interleukin 6 Homo sapiens 249-266 20065508-9 2009 We conclude that 1) colorectal carcinogenesis is accompanied by increased synthesis and release of proinflammatory cytokines such as IL-6 and IL-8; 2) simvastatin therapy results in a decrease in serum level of proinflammatory cytokines, especially IL-6 in CRC and 3) simvastatin inhibits release of IL-8 and IL-6 from colorectal cell lines. Simvastatin 151-162 interleukin 6 Homo sapiens 249-253 19790045-11 2009 The catabolic effects of injury plus TNFalpha appeared partly due to endogenous IL-6, since GAG loss was partially abrogated by an IL-6-blocking Fab. Glycosaminoglycans 92-95 interleukin 6 Homo sapiens 131-135 19653909-5 2009 We found the short-term (<24 h) activation of IL-6 involved the coordinate up-regulation of toll-like receptor-4 (TLR4) with complementary changes to NEU3 and ST3GAL5 that reduced ganglioside GM3 in a manner that augmented the activation of TLR4 and IL-6. gm3 195-198 interleukin 6 Homo sapiens 49-53 19885014-5 2009 Results showed that EPA, DHA, or troglitazone significantly reduced COX-2 expression, NF-kappaB luciferase activity, and PGE(2) and IL-6 production in a dose-dependent fashion. Eicosapentaenoic Acid 20-23 interleukin 6 Homo sapiens 132-136 19584292-7 2009 In addition, BEZ235 was able to target MM cells in the presence of exogenous interleukin-6, insulin-like growth factor-1, stromal cells, or osteoclasts, which are known to protect against various anti-MM agents. dactolisib 13-19 interleukin 6 Homo sapiens 77-90 19542367-5 2009 Additionally, cyclooxygenase-2 inhibition by NS-398 (N-(2-cyclohexyloxy-4-nitrophenyl)-methanesulfonamide) reduced the TNF-alpha-induced increase in IL-6 mRNA/protein, which was restored by stimulation with PGE(2) or EP2, EP3, and EP4 agonists. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 45-51 interleukin 6 Homo sapiens 149-153 19542367-5 2009 Additionally, cyclooxygenase-2 inhibition by NS-398 (N-(2-cyclohexyloxy-4-nitrophenyl)-methanesulfonamide) reduced the TNF-alpha-induced increase in IL-6 mRNA/protein, which was restored by stimulation with PGE(2) or EP2, EP3, and EP4 agonists. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 53-105 interleukin 6 Homo sapiens 149-153 19575800-8 2009 Poly-L-arginine enhanced the stimulus-induced IL-6 and IL-8 production, however, blocking arginine uptake and the enhanced IL-6 and IL-8 production appeared unrelated. polyarginine 0-15 interleukin 6 Homo sapiens 46-50 19575800-9 2009 The exaggerated IL-6 and IL-8 production due to arginine deficiency and to poly-L-arginine depend on a post-transcriptional and a transcriptional process, respectively. polyarginine 75-90 interleukin 6 Homo sapiens 16-20 19205663-11 2009 Both TNF-alpha and IL-6 levels were significantly reduced in the simvastatin group (p = 0.02 and p = 0.02, respectively), while no such difference was observed in the placebo group (p = 0.35 and 0.39, respectively). Simvastatin 65-76 interleukin 6 Homo sapiens 19-23 19483309-6 2009 PMA plus A23187 significantly increased IL-1beta, IL-6, IL-8, and TNF-alpha production compared with media control (p<0.05). Calcimycin 9-15 interleukin 6 Homo sapiens 50-54 19514995-6 2009 MW (1 mg/ml) inhibited PMA plus A23187-stimulated gene expression and production of TNF-alpha, IL-6, and IL-8. Calcimycin 32-38 interleukin 6 Homo sapiens 95-99 19324137-7 2009 The IL-6 and IL-8 levels were lower in the GAE group (ratio 0.83, 95% confidence interval: 0.68 to 1.02; p = 0.070) than in the GA group (ratio 0.90, 95% confidence interval: 0.78 to 1.02; p = 0.090). gae 43-46 interleukin 6 Homo sapiens 4-8 18775100-0 2009 Effects of a flaxseed-derived lignan supplement on C-reactive protein, IL-6 and retinol-binding protein 4 in type 2 diabetic patients. derived lignan 22-36 interleukin 6 Homo sapiens 71-75 19016317-13 2009 However, the plasma levels of IL-6 at 24 h and CRP at 72 h after stenting were higher in PES group compared with SES group (p < 0.05). polyether sulfone 89-92 interleukin 6 Homo sapiens 30-34 19060270-7 2009 Treatment with tyrphostin AG1295 (10 microM; P<0.01) or anti-IL-6 antibody (50 microg/mL; P<0.01) in the presence of BLF inhibited wound closure, whereas the addition of exogenous IL-6 and PDGF-BB promoted wound closure. Tyrphostins 15-25 interleukin 6 Homo sapiens 186-190 19135383-4 2009 We found that LPIL exerted a smaller effect on gene transcription than Dex; however, IL-1beta-inducible target genes such as the CXCL type chemokines IL-8, IL-1beta and IL-6 were all clearly suppressed by LPIL to the same degree as by Dex. lpil 14-18 interleukin 6 Homo sapiens 169-173 19135383-4 2009 We found that LPIL exerted a smaller effect on gene transcription than Dex; however, IL-1beta-inducible target genes such as the CXCL type chemokines IL-8, IL-1beta and IL-6 were all clearly suppressed by LPIL to the same degree as by Dex. lpil 205-209 interleukin 6 Homo sapiens 169-173 18654091-7 2009 Treatment with LQGV, AQGV, or LAGV prevented systemic release of TNF-[alpha] and IL-6 and was associated with reduced TNF-[alpha], IL-6, and E-selectin mRNA transcript levels in the liver. alanyl-glutaminyl-glycyl-valine 21-25 interleukin 6 Homo sapiens 131-135 19101624-5 2009 In the present study, using dendritic cells derived from CD34(+) cord blood cells, we showed that both NiSO(4) and CoCl(2) induced the expression of CD86, CD83, HLA-DR and CD40 and the production of IL-6 in human DCs while K(2)Cr(2)O(7) induced only a slight upregulation of CD86. cobaltous chloride 115-122 interleukin 6 Homo sapiens 199-203 19101624-10 2009 IL-6 production induced by NiSO(4) and CoCl(2) strongly depended on all MAPKs. cobaltous chloride 39-46 interleukin 6 Homo sapiens 0-4 19101266-6 2009 However, LVA was associated with significantly less inflammatory response postoperatively compared with MECC, as indicated by a significant difference in interleukin-6 (p = 0.002), C-reactive protein (p = 0.002), monocyte percentage (p = 0.006), tumor necrosis factor-alpha (p = 0.002), and polymorphonuclear elastase (p = 0.001). mevinolinic acid 9-12 interleukin 6 Homo sapiens 154-167 18515973-8 2009 7-ketocholesterol significantly increased the amount of intracellular IL-6 protein in the presence of brefeldin A. Brefeldin A 102-113 interleukin 6 Homo sapiens 70-74 19118698-7 2009 RESULTS: Vitreous fluid levels of VEGF, ICAM-1, IL-6, and MCP-1 were significantly higher in patients with DME than in nondiabetic patients (P<0.05, all respectively) or diabetic patients without retinopathy (P<0.05, all respectively). dme 107-110 interleukin 6 Homo sapiens 48-52 18986700-9 2008 Under hypoxic conditions (2% O(2)), IL-6 production was significantly reduced by both normal (p<0.01) and PE (p<0.05) placental tissue. o(2)) 29-34 interleukin 6 Homo sapiens 36-40 18809747-10 2008 We conclude that IL-6/sIL-6R increases ascorbic-acid-induced alkaline phosphatase activity through IGF-I production, implying that IL-6 acts not only as an osteolytic factor, but also as a mediator of osteoblastic differentiation in periodontal ligament cells. Ascorbic Acid 39-52 interleukin 6 Homo sapiens 17-21 18809747-10 2008 We conclude that IL-6/sIL-6R increases ascorbic-acid-induced alkaline phosphatase activity through IGF-I production, implying that IL-6 acts not only as an osteolytic factor, but also as a mediator of osteoblastic differentiation in periodontal ligament cells. Ascorbic Acid 39-52 interleukin 6 Homo sapiens 23-27 19967068-5 2008 Thus, it seems that tyrphostins, which are known as specific inhibitors of the ErbB2 kinase, may have non-specific suppressive effects on the IL-6/STAT3 pathway. Tyrphostins 20-31 interleukin 6 Homo sapiens 142-146 18825645-7 2008 HCO showed a trend toward a reduced relative increase in IL-6 concentration from commencement to end of experiment compared to control (P=0.07). hco 0-3 interleukin 6 Homo sapiens 57-61 18825645-8 2008 After pooling end-of-experiment plasma cytokine values of novel blood purification devices, we found HCO + ETX-A superior to H with regard to reduction of IL-1ra (-27.0 [-20.5]% vs. 8.1 [18.9]%; p<0.001) and IL-6 (-18.0 [38.3]% vs. -1.1 [24.3]%; P=0.050) compared to control. hco 101-104 interleukin 6 Homo sapiens 211-215 18825645-8 2008 After pooling end-of-experiment plasma cytokine values of novel blood purification devices, we found HCO + ETX-A superior to H with regard to reduction of IL-1ra (-27.0 [-20.5]% vs. 8.1 [18.9]%; p<0.001) and IL-6 (-18.0 [38.3]% vs. -1.1 [24.3]%; P=0.050) compared to control. etx-a 107-112 interleukin 6 Homo sapiens 211-215 18825645-9 2008 CONCLUSIONS: HCO and ETX-A appeared to significantly reduce plasma IL-1ra and, when combined, plasma IL-6 concentration as well. hco 13-16 interleukin 6 Homo sapiens 101-105 18547706-7 2008 The metal allergens nickel and cobalt could be detected by measuring Interleukin-6 and macrophage inflammatory protein 1-beta (MIP-1beta, CCL-4) in coculture supernatants. Nickel 20-26 interleukin 6 Homo sapiens 69-82 18795698-7 2008 Furthermore, there was significant correlation between postoperative liver function (total bilirubin, albumin) and HGF, IL-6. Bilirubin 91-100 interleukin 6 Homo sapiens 120-124 18762411-0 2008 Eicosapentaenoic acid inhibits interleukin-6 production in interleukin-1beta-stimulated C6 glioma cells through peroxisome proliferator-activated receptor-gamma. Eicosapentaenoic Acid 0-21 interleukin 6 Homo sapiens 31-44 18541548-8 2008 Changes in the DHA and EPA concentrations were negatively associated with changes in IL-1beta and IL-6 release for all subjects. Eicosapentaenoic Acid 23-26 interleukin 6 Homo sapiens 98-102 18222974-9 2008 In addition, MEVA attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated secretion of tumor necrosis factor-alpha, interleukin-6 (IL-6), and IL-8 in human mast cells. Calcimycin 87-93 interleukin 6 Homo sapiens 155-168 18222974-9 2008 In addition, MEVA attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated secretion of tumor necrosis factor-alpha, interleukin-6 (IL-6), and IL-8 in human mast cells. Calcimycin 87-93 interleukin 6 Homo sapiens 170-174 18071264-6 2007 LR inhibited the PMA plus A23187-induced increase in IL-6, IL-8, and TNF-alpha expression in HMC-1 cells. Calcimycin 26-32 interleukin 6 Homo sapiens 53-57 17982709-2 2007 We therefore investigated the presence of urinary IL-6 in patients with BPS/IC to find a possible correlation with the symptoms before and after glycosaminoglycan substitution therapy. Glycosaminoglycans 145-162 interleukin 6 Homo sapiens 50-54 17969629-6 2007 Our results indicate that heat and formalin treatments of probiotic microorganisms are equivalent inactivation methods in terms of induction of IL-6, IL-8, and IL-10 production in Caco-2-peripheral blood mononuclear cell cocultures and do not invert immune-modulatory effects. Formaldehyde 35-43 interleukin 6 Homo sapiens 144-148 18078616-1 2007 OBJECTIVES: Recent studies demonstrated in vivo the effectiveness of statins in reducing the inflammatory response in rheumatic diseases, and still more recently, simvastatin has been reported to inhibit in vitro IL-6 and IL-8 production by unstimulated fibroblast-like-synoviocytes (FLS) from rheumatoid arthritis (RA) patients. Simvastatin 163-174 interleukin 6 Homo sapiens 213-217 18078616-7 2007 Simvastatin significantly inhibited (about 20%) IL-6 and IL-8 production from IL-1-stimulated FLS. Simvastatin 0-11 interleukin 6 Homo sapiens 48-52 18078616-10 2007 CONCLUSION: Simvastatin significantly inhibits the production of IL-6 and IL-8 also in IL-1-stimulated FLS, even though to a lesser extent than in unstimulated cells, via a HMG-CoA-reductase block with an interference in prenylation process and NF-kB activation. Simvastatin 12-23 interleukin 6 Homo sapiens 65-69 17876051-8 2007 Kaempferol suppressed the expression of proinflammatory cytokine interleukin-6 and chemokines interleukin-8, monocyte chemoattractant protein-1, and regulated on activation, normal T-cell expressed and secreted. kaempferol 0-10 interleukin 6 Homo sapiens 65-78 17599452-0 2007 Usefulness of uric acid to predict changes in C-reactive protein and interleukin-6 in 3-year period in Italians aged 21 to 98 years. Uric Acid 14-23 interleukin 6 Homo sapiens 69-82 17599452-7 2007 The relation between UA and CRP persisted after adjustment for baseline IL-6. Uric Acid 21-23 interleukin 6 Homo sapiens 72-76 17599452-8 2007 Subjects with high UA at baseline had a progressively higher probability of developing clinically relevant increased IL-6 (>2.5 pg/ml) and CRP (>3 mg/L) during 3 years. Uric Acid 19-21 interleukin 6 Homo sapiens 117-121 17609508-4 2007 In addition, PVAE attenuated phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-alpha, IL-6, and IL-8 secretion in human mast cells. pvae 13-17 interleukin 6 Homo sapiens 118-122 17609508-4 2007 In addition, PVAE attenuated phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-alpha, IL-6, and IL-8 secretion in human mast cells. Calcimycin 89-95 interleukin 6 Homo sapiens 118-122 16781858-4 2007 Pretreatment with 100 microM EPA and DHA significantly decreased lipopolysaccharide (LPS)-stimulated THP-1 macrophage tumor necrosis factor (TNF) alpha, interleukin (IL) 1beta and IL-6 production (P<.02), compared to control cells. Eicosapentaenoic Acid 29-32 interleukin 6 Homo sapiens 180-184 16860297-7 2007 Exposure to the photochemically generated products of BD (primarily acrolein, acetaldehyde, formaldehyde, furan and ozone) induced significant increases in cytotoxicity, IL-8, and IL-6 gene expression compared to a synthetic mixture of primary products that was created by injecting the correct concentrations of the detected products from the irradiation experiments. Formaldehyde 92-104 interleukin 6 Homo sapiens 180-184 17395047-5 2007 Candesartan decreased Nt-proBNP (median value = 12.4% versus -20.4%; [candesartan] P = .05), and high-sensitivity C-reactive protein (hsCRP) (+5.32% versus -20.3% [candesartan]; P = 0.046), without significantly influencing serum interleukin-6, interleukin-18, adhesion molecules, or markers of oxidative stress. candesartan 0-11 interleukin 6 Homo sapiens 230-243 17312168-7 2007 Nickel-dependent HIF-1alpha activation primarily modulates expression of genes involved in proliferation, survival, metabolism, and signaling, albeit the induction of some proinflammatory nickel-response genes, most prominently IL-6, which we identified as novel bona fide HIF-1alpha target in this study, is also critically dependent on this pathway. Nickel 0-6 interleukin 6 Homo sapiens 228-232 16942919-3 2007 Simvastatin treatment did not inhibit AgLDL-induced macrophage lipid accumulation, but significantly increased the secretion of IL-1beta and IL-8 from macrophages, whilst inhibiting the secretion of tumor necrosis factor-alpha (TNF-alpha) and having no significant effect on IL-6 secretion. Simvastatin 0-11 interleukin 6 Homo sapiens 275-279 17597500-6 2007 It showed that DHSMT inhibited the production of TNF-alpha, IL-1beta, and IL-6 induced by LPS in a dose-dependent manner (p < 0.05). dhsmt 15-20 interleukin 6 Homo sapiens 74-78 17597500-7 2007 The maximal inhibition rates for TNF-alpha, IL-1beta, and IL-6 production by DHSMT were about 50.18%, 32.13%, and 38.03%, respectively. dhsmt 77-82 interleukin 6 Homo sapiens 58-62 16837651-6 2007 NS-398 also inhibited the enhancement of alpha-SMA expression by TGF-beta1, IL-1beta, and IL-6 in activated PSCs. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 0-6 interleukin 6 Homo sapiens 90-94 16574371-4 2006 FPT dose dependently decreased the gene expression and production of TNF-alpha and IL-6 on phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated HMC-1 cells. N-[[3-FLUORO-4-ETHOXY-PYRID-2-YL]ETHYL]-N'-[5-NITRILOMETHYL-PYRIDYL]-THIOUREA 0-3 interleukin 6 Homo sapiens 83-87 16574371-4 2006 FPT dose dependently decreased the gene expression and production of TNF-alpha and IL-6 on phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated HMC-1 cells. Calcimycin 151-157 interleukin 6 Homo sapiens 83-87 16857804-4 2006 RESULTS: We now report that CDDO-Imidazolide, previously shown to be a potent agent for control of inflammation, cell proliferation, and apoptosis, rapidly (within 30-60 minutes) and potently (at nanomolar levels) suppresses either constitutive or interleukin-6-induced STAT3 and STAT5 phosphorylation in human myeloma and lung cancer cells. 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole 28-44 interleukin 6 Homo sapiens 248-261 16757516-5 2006 The thiol N-acetyl-L-cysteine, the micronutrient selenite as well as selenoprotein P and the lipid peroxidation inhibitors alpha-tocopherol and butylated hydroxytoluene significantly lower both the number of TGFbeta1-initiated myofibroblasts and the secretion of HGF, VEGF and IL-6, correlating with a diminished invasive capacity of tumor cells. alpha-Tocopherol 123-139 interleukin 6 Homo sapiens 277-281 16723648-0 2006 Simvastatin decreases IL-6 and IL-8 production in epithelial cells. Simvastatin 0-11 interleukin 6 Homo sapiens 22-26 16723648-3 2006 Since oral epithelial cells participate importantly in periodontal inflammation, we measured simvastatin effects on interleukin-6 and interleukin-8 production by cultured human epithelial cell line (KB cells) in response to interleukin-1alpha. Simvastatin 93-104 interleukin 6 Homo sapiens 116-129 16651441-1 2006 We have analyzed in molecular detail how soy isoflavones (genistein, daidzein, and biochanin A) suppress nuclear factor-kappaB (NF-kappaB)-driven interleukin-6 (IL6) expression. daidzein 69-77 interleukin 6 Homo sapiens 146-159 16651441-1 2006 We have analyzed in molecular detail how soy isoflavones (genistein, daidzein, and biochanin A) suppress nuclear factor-kappaB (NF-kappaB)-driven interleukin-6 (IL6) expression. daidzein 69-77 interleukin 6 Homo sapiens 161-164 16832784-9 2006 CONCLUSION: Iodine induced thyrotoxicosis is associated with an increase of sVCAM-1 and IL-6 levels, possibly reflecting inflammatory and destructive processes in the thyroid gland. Iodine 12-18 interleukin 6 Homo sapiens 76-92 16336978-10 2006 It greatly attenuated I-R-induced NF-kappaB and AP-1 activation with decreased TNF-alpha, IL-6, and ICAM-1 production, but enhanced IL-10 production. Iodine 0-1 interleukin 6 Homo sapiens 90-94 16352705-5 2006 In primary human peripheral blood mononuclear cells, dose-dependent inhibition of LPS-induced tumor necrosis factor (TNF)-alpha, IL-6, MCP-1, and IL-1beta by tipifarnib was observed with no evidence of cytotoxicity. tipifarnib 158-168 interleukin 6 Homo sapiens 129-133 16511915-0 2006 Simvastatin inhibits production of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosis factor-alpha in fibroblast-like synoviocytes from patients with rheumatoid arthritis. Simvastatin 0-11 interleukin 6 Homo sapiens 35-48 16511915-0 2006 Simvastatin inhibits production of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosis factor-alpha in fibroblast-like synoviocytes from patients with rheumatoid arthritis. Simvastatin 0-11 interleukin 6 Homo sapiens 50-54 16676702-1 2006 Attenuation of exercise-induced interleukin-6 (IL-6) responses by carbohydrate (CHO) has been demonstrated in studies comparing controlled doses (> or = 0.9 g x kg(-1) x h(-1)) to placebo, but not in studies of voluntary intake. CAV protocol 80-83 interleukin 6 Homo sapiens 47-51 16676702-2 2006 This study sought to determine if attenuation of the IL-6 response during a 32.2-km mountain trail race occurs for high compared to low ad libitum CHO intakes. CAV protocol 147-150 interleukin 6 Homo sapiens 53-57 16676702-5 2006 IL-6 0 h post-race (P < 0.05) was higher in the low (40.2 +/- 22.7 pg x mL(-1)) compared to the high CHO group (32.7 +/- 22.1 pg x mL(-1)). CAV protocol 104-107 interleukin 6 Homo sapiens 0-4 16676702-7 2006 Attenuation of exercise-induced IL-6 is apparent across a range of CHO intakes. CAV protocol 67-70 interleukin 6 Homo sapiens 32-36 16234304-6 2006 Lower alpha-linolenic acid was associated with higher C-reactive protein and IL-1ra, and lower eicosapentaenoic acid was associated with higher IL-6 and lower TGFbeta. Eicosapentaenoic Acid 95-116 interleukin 6 Homo sapiens 144-148 16997791-7 2006 Furthermore, AIAE attenuated the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis factor-alpha and interleukin-6 secretion in human mast cells. Calcimycin 88-94 interleukin 6 Homo sapiens 138-151 17201633-7 2006 SFWE suppressed PMA plus A23187-induced TNF-alpha, IL-6, and GM-CSF production in dose-dependent manners. Calcimycin 25-31 interleukin 6 Homo sapiens 51-55 16155293-8 2005 Collectively, these data demonstrate for the first time that trans-10, cis-12 CLA promotes NFkappaB activation and subsequent induction of IL-6, which are at least in part responsible for trans-10, cis-12 CLA-mediated suppression of peroxisome proliferator-activated receptor gamma target gene expression and insulin sensitivity in mature human adipocytes. cis-12 cla 71-81 interleukin 6 Homo sapiens 139-143 16260731-3 2005 IL-32 synergized with the NOD1- and NOD2-specific muropeptides of peptidoglycans for the release of IL-1beta and IL-6 (a 3- to 10-fold increase). muropeptides 50-62 interleukin 6 Homo sapiens 113-117 16275545-7 2005 Multivariate regression analysis showed the existence of a relationship between simvastatin therapy and serum IL-6 level (r=0.83; p<0.05) in the homozygotic men. Simvastatin 80-91 interleukin 6 Homo sapiens 110-114 15888346-0 2005 Novel p38 MAP kinase inhibitor R-130823 suppresses IL-6, IL-8 and MMP-13 production in spheroid culture of human synovial sarcoma cell line SW 982. 2-(4-fluorophenyl)-4-(1-phenethyl-1,2,3,6-tetrahydropyridin-4-yl)-3-(pyridin-4-yl)-1H-pyrrole 31-39 interleukin 6 Homo sapiens 51-55 15888346-8 2005 A novel p38 MAP kinase inhibitor, R-130823, inhibited the release of IL-6, IL-8 and MMP-13 in a concentration-dependent manner, but not that of IL-1beta or MMP-2. 2-(4-fluorophenyl)-4-(1-phenethyl-1,2,3,6-tetrahydropyridin-4-yl)-3-(pyridin-4-yl)-1H-pyrrole 34-42 interleukin 6 Homo sapiens 69-73 16202919-14 2005 beta-cyclodextrin-treated chondrocytes released significantly less IL-6 in the supernatant culture media. betadex 0-17 interleukin 6 Homo sapiens 67-71 16123706-9 2005 Taken together, the activation of IL-6 and IL-8 mRNA gene expression may be one of the pathogenesis of zinc oxide-eugenol based and epoxy resin based root canal sealers-induced periapical inflammation. Eugenol 114-121 interleukin 6 Homo sapiens 34-38 15790728-8 2005 Finally, TSH reduced both the intracellular Ca(2+) ([Ca(2+)](i)) rise and IL-6 release triggered by P2Rs stimulation. Thyrotropin 9-12 interleukin 6 Homo sapiens 74-78 15924880-5 2005 Sabaeksan (1 mg/ml) inhibited PMA plus A23187-induced TNF-alpha, IL-6, and IL-8 secretion by 43.86+/-5.26%, 56.39+/-3.65%, and 63.48+/-2.54%, respectively. Calcimycin 39-45 interleukin 6 Homo sapiens 65-69 15718495-2 2005 METHODS AND RESULTS: Transient transfection and luciferase assay in HepG2 human hepatoma-derived cells demonstrated that IL-6 increased PAI-1 promoter activity and mevastatin decreased IL-6-inducible response. mevastatin 164-174 interleukin 6 Homo sapiens 185-189 15718495-8 2005 Mevastatin attenuated IL-6-mediated increase of C/EBPdelta protein in the nuclear extracts. mevastatin 0-10 interleukin 6 Homo sapiens 22-26 15582581-5 2005 Over the same concentration range of the nucleotide that was effective for IL-6 synthesis, ATP caused an increase in the intracellular Ca(2+) concentration ([Ca(2+)](i)), which increase was inhibited by pretreatment with suramin, a P2Y receptor antagonist, or 2-aminoethoxydiphenyl borate (2-APB), an inositol 1,4,5-trisphosphate receptor blocker, but not by the extracellular Ca(2+)-chelating agent EGTA. Suramin 221-228 interleukin 6 Homo sapiens 75-79 15308634-11 2004 This together with the suppression of UVA irradiation-induced IL-6 release in the presence of Trolox, a chain breaker of PCOOH-initiated lipid peroxidation, indicates that UVA irradiation-induced PCOOHs and subsequent lipid peroxides initiate the NFkappaB-mediated induction of IL-6, which mediates the induction of MMP-1. Lipid Peroxides 218-233 interleukin 6 Homo sapiens 62-66 15369747-6 2004 In diabetic patients, plasma tHcy correlated positively with urinary albumin, fibrinogen, IL-6 and plasmin-alpha2-antiplasmin complex (PAP), while plasma tHcy correlated negatively with creatinine clearance (Ccr) and protein C activity. thcy 29-33 interleukin 6 Homo sapiens 90-94 15369747-7 2004 After adjustment for Ccr, IL-6 and protein C activity were significantly associated with plasma tHcy. thcy 96-100 interleukin 6 Homo sapiens 26-30 15571210-6 2004 The adenosine receptor agonist 5"N-ethylcarboxamido-adenosine (NECA) used to modify cytokine release in cultures of whole blood taken from the patients, depressed the release of tumour necrosis factor-alpha (TNFalpha), but failed to depress the release of interleukin-1b (IL-1b) or interleukin-6 (IL-6), a difference from earlier studies of healthy control subjects and, thus, a difference which may contribute to the disease activity. Adenosine-5'-(N-ethylcarboxamide) 31-61 interleukin 6 Homo sapiens 282-295 15571210-6 2004 The adenosine receptor agonist 5"N-ethylcarboxamido-adenosine (NECA) used to modify cytokine release in cultures of whole blood taken from the patients, depressed the release of tumour necrosis factor-alpha (TNFalpha), but failed to depress the release of interleukin-1b (IL-1b) or interleukin-6 (IL-6), a difference from earlier studies of healthy control subjects and, thus, a difference which may contribute to the disease activity. Adenosine-5'-(N-ethylcarboxamide) 31-61 interleukin 6 Homo sapiens 297-301 15571210-6 2004 The adenosine receptor agonist 5"N-ethylcarboxamido-adenosine (NECA) used to modify cytokine release in cultures of whole blood taken from the patients, depressed the release of tumour necrosis factor-alpha (TNFalpha), but failed to depress the release of interleukin-1b (IL-1b) or interleukin-6 (IL-6), a difference from earlier studies of healthy control subjects and, thus, a difference which may contribute to the disease activity. Adenosine-5'-(N-ethylcarboxamide) 63-67 interleukin 6 Homo sapiens 282-295 15571210-6 2004 The adenosine receptor agonist 5"N-ethylcarboxamido-adenosine (NECA) used to modify cytokine release in cultures of whole blood taken from the patients, depressed the release of tumour necrosis factor-alpha (TNFalpha), but failed to depress the release of interleukin-1b (IL-1b) or interleukin-6 (IL-6), a difference from earlier studies of healthy control subjects and, thus, a difference which may contribute to the disease activity. Adenosine-5'-(N-ethylcarboxamide) 63-67 interleukin 6 Homo sapiens 297-301 15229366-0 2004 Microbial stimulation by Mycoplasma fermentans synergistically amplifies IL-6 release by human lung fibroblasts in response to residual oil fly ash (ROFA) and nickel. Nickel 159-165 interleukin 6 Homo sapiens 73-77 15251176-2 2004 Previous work has revealed that SM induces the production of inflammatory cytokines, including IL-8, IL-6, TNF-alpha, and IL-1beta, in keratinocytes. Samarium 32-34 interleukin 6 Homo sapiens 101-105 15551657-9 2004 IL-6 secretion from U266 cells was abrogated on treatment with simvastatin, whereas total tyrosine phosphorylation was unaffected. Simvastatin 63-74 interleukin 6 Homo sapiens 0-4 18203325-11 2008 CONCLUSION: These data, together with our previous report, suggest that low (pharmacological range) and high concentrations of simvastatin affect FLS differently: (1) at a low concentration, it inhibits IL-6 and IL-8 production and the cell proliferation of FLS induced by TNF-alpha (2) at high concentrations, it induces apoptosis in FLS. Simvastatin 127-138 interleukin 6 Homo sapiens 203-207 19043252-4 2008 Moreover, candesartan treatment exhibited a tendency of reduction in inflammation markers such as high sensitive C-reactive protein (hsCRP) and interleukin-6 (IL-6). candesartan 10-21 interleukin 6 Homo sapiens 144-157 19043252-4 2008 Moreover, candesartan treatment exhibited a tendency of reduction in inflammation markers such as high sensitive C-reactive protein (hsCRP) and interleukin-6 (IL-6). candesartan 10-21 interleukin 6 Homo sapiens 159-163 18264935-6 2008 As expected, simvastatin caused significant reductions in total cholesterol, LDL cholesterol and triglycerides, as well as in C-reactive protein (CRP; -28%, p=0.001) and IL-6 (-20%, p=0.05) but failed to decrease plasma ADMA both in crude and adjusted analyses. Simvastatin 13-24 interleukin 6 Homo sapiens 170-174 18510246-13 2008 These inhibitory effects were significant at both the mRNA and protein levels (protein of IL-6: t1h = 7.9154, t2h = 10.863, t4h = 8.2451, t8h = 13.5063. protein of IL-8: t1h = 8.5663, t2h = 20.5169, t4h = 25.1580, t8h = 34.8699. mRNA of IL-6: t1h = 12.0235, t2h = 13.2894, t4h = 24.0799, t8h = 27.2261. mRNA of IL-8: t1h = 20.9424, t2h = 24.1314, t4h = 29.8580, t8h = 47.9442. 3-Chloro-N-[2-(2,4-dioxo-1,3-thiazolidin-3-yl)ethyl]benzamide 124-127 interleukin 6 Homo sapiens 90-94 18510246-13 2008 These inhibitory effects were significant at both the mRNA and protein levels (protein of IL-6: t1h = 7.9154, t2h = 10.863, t4h = 8.2451, t8h = 13.5063. protein of IL-8: t1h = 8.5663, t2h = 20.5169, t4h = 25.1580, t8h = 34.8699. mRNA of IL-6: t1h = 12.0235, t2h = 13.2894, t4h = 24.0799, t8h = 27.2261. mRNA of IL-8: t1h = 20.9424, t2h = 24.1314, t4h = 29.8580, t8h = 47.9442. 3-Chloro-N-[2-(2,4-dioxo-1,3-thiazolidin-3-yl)ethyl]benzamide 199-202 interleukin 6 Homo sapiens 90-94 17888632-0 2007 FK506 induces interleukin-6 secretion from UVB irradiated cultured human keratinocytes via p38 mitogen-activated protein kinase pathway: implication on mechanisms of tacrolimus-induced skin irritation. Tacrolimus 0-5 interleukin 6 Homo sapiens 14-27 17888632-0 2007 FK506 induces interleukin-6 secretion from UVB irradiated cultured human keratinocytes via p38 mitogen-activated protein kinase pathway: implication on mechanisms of tacrolimus-induced skin irritation. Tacrolimus 166-176 interleukin 6 Homo sapiens 14-27 17920466-4 2007 Phagocytosis of the polyethylene particles or retrieved polyethylene particles by differentiated U937 cells stimulated the release of cytokines including interleukin 1beta, interleukin 6, interleukin 8, and vascular endothelial growth factor. Polyethylene 20-32 interleukin 6 Homo sapiens 173-186 17920466-4 2007 Phagocytosis of the polyethylene particles or retrieved polyethylene particles by differentiated U937 cells stimulated the release of cytokines including interleukin 1beta, interleukin 6, interleukin 8, and vascular endothelial growth factor. Polyethylene 56-68 interleukin 6 Homo sapiens 173-186 18048020-4 2007 CNTO2424 down-regulates poly(I:C)-induced production of IL-6, IL-8, MCP-1, RANTES, and IP-10 in human lung epithelial cells. Iodine 29-30 interleukin 6 Homo sapiens 56-60 17262802-7 2007 RESULTS: Treatment with alpha-tocopherol succinate (VES) inhibits NF-kappaB but augments AP-1 activity, reduces expression of IL-6, IL-8, and VEGF, suppresses cell adhesion, ICAM-1 and gp130 expression in androgen-independent PC-3, DU-145, and CA-HPV-10 cells. alpha-Tocopherol 24-50 interleukin 6 Homo sapiens 126-130 17632672-2 2007 AIM: To evaluate the behaviour of some cytokines and the possible anti-inflammatory activity of IL-6 (a protein involved in cortisone synthesis) on acute PCA- BG pleural fluid, since this cytokine is usually considered as an acute phase reaction protein associated to high concentrations of TNF-alpha and IL-1 beta in immediate inflammatory reactions. Cortisone 124-133 interleukin 6 Homo sapiens 96-100 17383342-8 2007 RESULTS: Simvastatin significantly reduced the postoperative peak values of interleukin (IL)-6 and IL-8. Simvastatin 9-20 interleukin 6 Homo sapiens 76-94 17196927-3 2007 Carotenoids quench free radicals, reduce damage from reactive oxygen species, and appear to modulate redox-sensitive transcription factors such as NF-kappaB that are involved in the upregulation of IL-6 and other proinflammatory cytokines. Carotenoids 0-11 interleukin 6 Homo sapiens 198-202 16527283-8 2007 However, pre-treatment with Vitamin C before ET-1 prevented the decrease in endothelium-dependent and -independent vasodilatation as well as the increase in IL-6 levels (1.20+/-0.28 versus 1.29+/-0.27 ng/ml; P=0.57). Ascorbic Acid 28-37 interleukin 6 Homo sapiens 157-161 17178390-4 2007 EPA significantly inhibited the release of nitric oxide (NO), prostaglandin E(2) (PGE(2)) and proinflammatory cytokines such as interleukin (IL)-1beta, IL-6 and tumor necrosis factor (TNF)-alpha in a dose-dependent manner. Eicosapentaenoic Acid 0-3 interleukin 6 Homo sapiens 152-156 17710582-9 2007 IL-10, TNF-alpha, and IL-6 production from preeclamptic placenta and PBMCs were inhibited by diazoxide and furosemide. Diazoxide 93-102 interleukin 6 Homo sapiens 22-26 17261959-7 2007 The effect of CRP on VCAM-1 expression in HUVECs and supernatant levels of MCP-1 and IL-6 were significantly suppressed by 25 micromol/L simvastatin with stepwise increased suppression as simvastatin dose increased to 50, 75, and 100 micromol/L (all P < 0.0001). Simvastatin 137-148 interleukin 6 Homo sapiens 85-89 17261959-7 2007 The effect of CRP on VCAM-1 expression in HUVECs and supernatant levels of MCP-1 and IL-6 were significantly suppressed by 25 micromol/L simvastatin with stepwise increased suppression as simvastatin dose increased to 50, 75, and 100 micromol/L (all P < 0.0001). Simvastatin 188-199 interleukin 6 Homo sapiens 85-89 16796997-4 2006 Further, omega-3 eicosapentaenoic acid is capable of down-regulating the production and effect of a number of mediators of cachexia, such as IL-1, IL-6, TNF-alpha and proteolysis-inducing factor. Eicosapentaenoic Acid 9-38 interleukin 6 Homo sapiens 147-151 16765939-1 2006 We examined whether the 22beta-methoxyolean-12-ene-3beta,24(4beta)-diol (ME3738)-mediated selective induction of interleukin-6 increased alpha1-acid glycoprotein and serum amyloid A expression, and whether these proteins protected against liver injury in vitro and in vivo. 24(4beta)-diol 57-71 interleukin 6 Homo sapiens 113-126 16859130-7 2006 FK506 obviously decreased LDH levels in the supernatant (P < 0.05) and attenuated IL-6 induced suppression of albumin synthesis (P < 0.01). Tacrolimus 0-5 interleukin 6 Homo sapiens 85-89 16859130-10 2006 FK506 protected against the suppression of hepatic albumin synthesis caused by IL-6, suggesting its potential role in improving hypoalbuminaemia in immune glomerulonephritis. Tacrolimus 0-5 interleukin 6 Homo sapiens 79-83 16547349-10 2006 At 50 nM, A1, A2, and the endogenous cannabinoid anandamide (CB2 Ki >200 nM) up-regulated constitutive interleukin (IL)-6 expression in human whole blood in a seemingly CB2-dependent manner. Cannabinoids 37-48 interleukin 6 Homo sapiens 106-124 16830109-7 2006 However, FK506 decreased LDH levels in the supernatant of cells (P < 0.05) and prevented the IL-6-induced suppression of albumin synthesis (P < 0.01) in a dose dependent manner. Tacrolimus 9-14 interleukin 6 Homo sapiens 96-100 16830109-11 2006 FK506 but not CSA protects against the suppression of hepatic albumin synthesis caused by IL-6. Tacrolimus 0-5 interleukin 6 Homo sapiens 90-94 16612254-8 2006 There was a stepwise reduction in production of TNF-alpha and IL-6 with increasing doses of diazoxide, hydralazine and furosemide by placentas and PBMCs from these women with normal pregnancies. Diazoxide 92-101 interleukin 6 Homo sapiens 62-66 16612254-9 2006 CONCLUSION: Our data suggest that the antihypertensive drugs clonidine and hydralazine can stimulate production of the circulating anti-inflammatory cytokine IL-10, whereas furosemide and diazoxide inhibit the production of this cytokine and the proinflammatory cytokines TNF-alpha and IL-6 by placentas and PBMCs. Diazoxide 188-197 interleukin 6 Homo sapiens 286-290 16635740-0 2006 Herbal melanin modulates tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6) and vascular endothelial growth factor (VEGF) production. Melanins 7-14 interleukin 6 Homo sapiens 66-79 16635740-0 2006 Herbal melanin modulates tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6) and vascular endothelial growth factor (VEGF) production. Melanins 7-14 interleukin 6 Homo sapiens 81-85 16635740-3 2006 In this study we report the effects of a herbal melanin, extracted from Nigella sativa L., on the production of three cytokines [tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6) and vascular endothelial growth factor (VEGF)], by human monocytes, total peripheral blood mononuclear cells (PBMC) and THP-1 cell line. Melanins 48-55 interleukin 6 Homo sapiens 170-183 15201697-14 2004 The ratios of IL-6 to IL-10 and IL-8 to IL-10 were significantly lower in DZX groups than in controls (P = 0.025 and P = 0.041 for each, respectively). Diazoxide 74-77 interleukin 6 Homo sapiens 14-18 15024666-1 2004 We have previously shown that vitamin C supplementation affects recovery from an unaccustomed bout of demanding exercise, with the most pronounced effect being that on plasma interleukin-6 concentration. Ascorbic Acid 30-39 interleukin 6 Homo sapiens 175-188 15070698-3 2004 CDDO-IM also triggers apoptosis in bone marrow stromal cells (BMSCs) and decreases interleukin-6 (IL-6) secretion induced by MM cell adhesion to BMSCs. 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole 0-7 interleukin 6 Homo sapiens 83-96 15070698-3 2004 CDDO-IM also triggers apoptosis in bone marrow stromal cells (BMSCs) and decreases interleukin-6 (IL-6) secretion induced by MM cell adhesion to BMSCs. 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole 0-7 interleukin 6 Homo sapiens 98-102 15246121-9 2004 Low IL-6 was observed in cell cultures of patients when stimulated with PDBu + A23187. Calcimycin 79-85 interleukin 6 Homo sapiens 4-8 16635740-3 2006 In this study we report the effects of a herbal melanin, extracted from Nigella sativa L., on the production of three cytokines [tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6) and vascular endothelial growth factor (VEGF)], by human monocytes, total peripheral blood mononuclear cells (PBMC) and THP-1 cell line. Melanins 48-55 interleukin 6 Homo sapiens 185-189 16635740-5 2006 Melanin induced TNF-alpha, IL-6 and VEGF mRNA expression by the monocytes, PBMC and THP-1 cell line. Melanins 0-7 interleukin 6 Homo sapiens 27-31 2554932-3 1989 In this study, we demonstrated that monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals, and to a lesser extent, hydroxyapatite crystals, increased IL-6 production by synoviocytes and monocytes in vitro. Uric Acid 54-57 interleukin 6 Homo sapiens 171-175 16635740-6 2006 On the protein level, melanin significantly induced TNF-alpha and IL-6 protein production and inhibited VEGF production by monocytes and PBMC. Melanins 22-29 interleukin 6 Homo sapiens 66-70 3263382-5 1988 While the NKSN contained small amounts of IL-6 (0.1 U/ml) and IL-6 could increase Ig synthesis in vitro, the optimal IL-6 enhancement was far less than that observed with NKSN. nksn 10-14 interleukin 6 Homo sapiens 42-46 16322071-6 2006 Gallic acid decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated pro-inflammatory cytokine gene expression and production such as TNF-alpha and IL-6 in human mast cells. Calcimycin 81-87 interleukin 6 Homo sapiens 178-182 16373656-5 2006 ADAM-9 promoted a 5-fold increase in IL-6, but not IL-1beta mRNA, and a dose- and time-dependent increase in IL-6 production by hOBs (P < .01). hobs 128-132 interleukin 6 Homo sapiens 109-113 16373656-8 2006 Antibodies to ADAM-9 and alpha(v)beta5 integrin inhibited myeloma cell-induced IL-6 production by hOBs (P < .01). hobs 98-102 interleukin 6 Homo sapiens 79-83 16373656-9 2006 Furthermore, inhibitors of p38 MAPK and cPLA2, but not NF-kappaB and JAK2, signaling pathways inhibited ADAM-9-induced IL-6 production by hOBs (P < .01). hobs 138-142 interleukin 6 Homo sapiens 119-123 15078991-5 2004 In addition, we found that all of the protease inhibitors, except for indinavir, blocked interleukin-6 (IL-6)-stimulated phosphorylation of both signal transducer and activator of transcription 3 (STAT 3) and extracellular signal-regulated kinase 1/2 in U266 and RPMI8226 MM cells. Indinavir 70-79 interleukin 6 Homo sapiens 89-102 15078991-5 2004 In addition, we found that all of the protease inhibitors, except for indinavir, blocked interleukin-6 (IL-6)-stimulated phosphorylation of both signal transducer and activator of transcription 3 (STAT 3) and extracellular signal-regulated kinase 1/2 in U266 and RPMI8226 MM cells. Indinavir 70-79 interleukin 6 Homo sapiens 104-108 15312472-0 2004 [Changes in plasma levels of LPS, TNFalpha and IL-6 in burn patients with severe infection treated with Imipenem or Cefoperazone]. Imipenem 104-112 interleukin 6 Homo sapiens 47-51 15312472-1 2004 OBJECTIVE: To observe the changes in plasma levels of lipopolysaccharide (LPS), tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) in burn patients with severe infection treated with Imipenem or Cefoperazone. Imipenem 197-205 interleukin 6 Homo sapiens 124-137 3108877-0 1987 Rapid enhancement of beta 2-interferon/B-cell differentiation factor BSF-2 gene expression in human fibroblasts by diacylglycerols and the calcium ionophore A23187. Calcimycin 157-163 interleukin 6 Homo sapiens 69-74 15312472-1 2004 OBJECTIVE: To observe the changes in plasma levels of lipopolysaccharide (LPS), tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) in burn patients with severe infection treated with Imipenem or Cefoperazone. Imipenem 197-205 interleukin 6 Homo sapiens 139-143 16054696-5 2006 Here, we show that pravastatin and simvastatin prevent the induction of CRP expression in human hepatoma Hep3B cells exposed to proinflammatory cytokines IL-6 and IL-1beta The nitric oxide (NO) donor, sodium nitroprusside, also prevented the induction of CRP expression while the CRP inducers IL-6 and IL-1beta were present with the cells. Simvastatin 35-46 interleukin 6 Homo sapiens 154-158 16054696-5 2006 Here, we show that pravastatin and simvastatin prevent the induction of CRP expression in human hepatoma Hep3B cells exposed to proinflammatory cytokines IL-6 and IL-1beta The nitric oxide (NO) donor, sodium nitroprusside, also prevented the induction of CRP expression while the CRP inducers IL-6 and IL-1beta were present with the cells. Simvastatin 35-46 interleukin 6 Homo sapiens 293-297 3108877-2 1987 We have examined the possibility that IFN-beta 2 gene expression is regulated through activation, by diacylglycerol, of the protein kinase C pathway. Diglycerides 101-115 interleukin 6 Homo sapiens 38-48 14688319-6 2004 Furthermore, NK cells respond to poly(I:C) by producing proinflammatory cytokines like IL-6 and IL-8, as well as the antiviral cytokine IFN-gamma. Iodine 38-39 interleukin 6 Homo sapiens 87-91 3108877-3 1987 The synthetic diacylglycerols 1,2-dioctanoylglycerol (diC8) and 1-oleoyl-2-acetylglycerol strongly enhanced IFN-beta 2, but not IFN-beta 1, gene expression in human fibroblasts (FS-4 strain). Diglycerides 14-29 interleukin 6 Homo sapiens 108-118 3108877-8 1987 The calcium ionophore A23187 (1-10 microM) also elicited an increase in the level of IFN-beta 2 mRNA in FS-4 fibroblasts; appropriate combinations of A23187 and diC8 had at least an additive effect in enhancing IFN-beta 2 mRNA levels. Calcimycin 22-28 interleukin 6 Homo sapiens 85-95 3108877-8 1987 The calcium ionophore A23187 (1-10 microM) also elicited an increase in the level of IFN-beta 2 mRNA in FS-4 fibroblasts; appropriate combinations of A23187 and diC8 had at least an additive effect in enhancing IFN-beta 2 mRNA levels. Calcimycin 22-28 interleukin 6 Homo sapiens 211-221 14623497-4 2003 A significant and inverse correlation was found between CSF IL-6 (not IL-10) and RBC membrane PUFAs levels in both haloperidol-treated and medication-free patients with schizophrenia. Haloperidol 115-126 interleukin 6 Homo sapiens 60-64 14653390-4 2003 RESULTS: The results showed that IL-6 elicited an inhibitory effect on collagen and GAG levels in CLP fibroblasts by lowering hyaluronan and dermatan sulfate secretion. Glycosaminoglycans 84-87 interleukin 6 Homo sapiens 33-37 16458189-5 2006 Ascorbate supplementation increased the venoarterial concentration difference (v-adiff) of lipid hydroperoxides (LH), interleukin (IL)-6 and vascular endothelial growth factor (VEGF) protein during ischemia. Ascorbic Acid 0-9 interleukin 6 Homo sapiens 118-136 3108877-8 1987 The calcium ionophore A23187 (1-10 microM) also elicited an increase in the level of IFN-beta 2 mRNA in FS-4 fibroblasts; appropriate combinations of A23187 and diC8 had at least an additive effect in enhancing IFN-beta 2 mRNA levels. Calcimycin 150-156 interleukin 6 Homo sapiens 85-95 16531897-8 2006 The increase in CRP was attenuated significantly by 12% CHO only (P < 0.05), whereas the increase in cortisol and IL-6 was significantly reduced by 6 and 12% CHO (P < 0.001). CAV protocol 161-164 interleukin 6 Homo sapiens 117-121 14653390-4 2003 RESULTS: The results showed that IL-6 elicited an inhibitory effect on collagen and GAG levels in CLP fibroblasts by lowering hyaluronan and dermatan sulfate secretion. Hyaluronic Acid 126-136 interleukin 6 Homo sapiens 33-37 3108877-8 1987 The calcium ionophore A23187 (1-10 microM) also elicited an increase in the level of IFN-beta 2 mRNA in FS-4 fibroblasts; appropriate combinations of A23187 and diC8 had at least an additive effect in enhancing IFN-beta 2 mRNA levels. Calcimycin 150-156 interleukin 6 Homo sapiens 211-221 33550688-5 2021 All laboratory and clinical parameters were assessed before and within 24hr after tocilizumab administration RESULTS: After receiving TCZ, all patients showed significantly lower median IL 6, LDH, CRP, ferritin , TLC at p<0.001 and D-Dimer at p=0.223 than their baseline levels. tioconazole 134-137 interleukin 6 Homo sapiens 186-190 14599443-7 2003 Moreover, fluoro-edenite interfered with epithelial cell physiology, by reducing the proliferation rate without perturbing the cell cycle and increasing the release of the proinflammatory cytokine IL-6, one of the main mediators of asbestos-induced pathophysiological response. Asbestos 232-240 interleukin 6 Homo sapiens 197-201 16249194-11 2006 In the in vitro studies, the average value for cell-associated IL-6 and IL-8 was higher in CKD (155+/-95 pg/ml monocytes for IL-6 and 722+/-921 pg/ml monocytes for IL-8) vs HS (137+/-87 pg/ml monocytes and 186+/-125 pg/ml monocytes) (P<0.01) and was not affected by simvastatin alone. Simvastatin 269-280 interleukin 6 Homo sapiens 63-67 33556876-5 2021 Our results showed that PCB2DG suppressed the production of IL-17, tumor necrosis factor (TNF)-alpha, IL-1beta, and IL-6 with the suppression of transcription factors expression. procyanidin B2-3,3'-di-O-gallate 24-30 interleukin 6 Homo sapiens 116-120 16846535-7 2006 In the presence of 100 nmol/l cortisone, IL-6 production--a characteristic feature of synovial derived fibroblasts--was significantly reduced in synovial but not dermal or bone marrow fibroblasts. Cortisone 30-39 interleukin 6 Homo sapiens 41-45 13129863-6 2003 RESULTS: The vitreous levels of both IL-6 and VEGF were significantly higher in the subjects with DME than in control subjects (P<0.0001 and P<0.0001, respectively). dme 98-101 interleukin 6 Homo sapiens 37-41 13129863-8 2003 Vitreous levels of both IL-6 and VEGF were significantly higher in subjects with hyperfluorescent DME than in those with minimally fluorescent DME (P = 0.0008 and P = 0.0038, respectively). dme 98-101 interleukin 6 Homo sapiens 24-28 13129863-8 2003 Vitreous levels of both IL-6 and VEGF were significantly higher in subjects with hyperfluorescent DME than in those with minimally fluorescent DME (P = 0.0008 and P = 0.0038, respectively). dme 143-146 interleukin 6 Homo sapiens 24-28 33378113-8 2021 RESULTS: Fatigue, depressive symptomatology, and serum IL-6 increased significantly over time in the ADT+ group versus the CA- group; rates of cognitive impairment also changed significantly between the groups. adt 101-104 interleukin 6 Homo sapiens 55-59 13129863-9 2003 CONCLUSIONS: We found that the levels of both IL-6 and VEGF were elevated in the vitreous fluid of subjects with hyperfluorescent DME. dme 130-133 interleukin 6 Homo sapiens 46-50 16538876-12 2006 A strong positive correlation was found between D/P creat and dialysate IL-6 (rho = 0.77, p < 0.0001) at baseline, but not at 1 year. creat 52-57 interleukin 6 Homo sapiens 72-76 12885745-10 2003 Furthermore, plasma concentrations of tumor necrosis factor-alpha, interleukin-6, and brain natriuretic peptide were significantly lower in the simvastatin group compared with the placebo group. Simvastatin 144-155 interleukin 6 Homo sapiens 67-80 33378113-11 2021 CONCLUSIONS: Results of this preliminary study suggest that increases in circulating IL-6, perhaps due to testosterone inhibition, may play a role in fatigue secondary to receipt of ADT. adt 182-185 interleukin 6 Homo sapiens 85-89 33460754-7 2021 In addition, AG490 and IL-6 were used in vitro to explore the function of IL-6/STAT3 pathway in the protective effect of MSU. Uric Acid 121-124 interleukin 6 Homo sapiens 74-78 12889010-10 2003 Titanium dioxide-coated silicone inhibited IL-6 production by 77% compared to uncoated silicone. titanium dioxide 0-16 interleukin 6 Homo sapiens 43-47 16378115-8 2005 Compared with those in control groups, IL-6 level decreased obviously in lidocaine group from T2 to T4, but IL-8 level remained unchanged significantly. Lidocaine 73-82 interleukin 6 Homo sapiens 39-43 15936049-10 2005 Furthermore, LAE decreased the secretion of TNF-alpha and IL-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated human mast cells. Calcimycin 127-133 interleukin 6 Homo sapiens 58-62 12794182-11 2003 Furthermore, CHO ingestion blunted the increase in plasma IL-6 levels (P<0.05) at end of exercise (26.0+/-3.7 pg ml(-1) in the control vs. 15.6+/-2.4 pg ml(-1) in the CHO trial). CAV protocol 13-16 interleukin 6 Homo sapiens 58-62 16263508-5 2005 Exposure to OE-UDP, OE-DEP, UDP, DEP, and 2,3,7,8-tetrachlorodibenzo-p-dioxin led to a greater increase of interleukin (IL)-8, tumor necrosis factor-alpha, and cyclooxygenase-2 mRNA expression than did the stripped particles, whereas sUDP, sDEP, UDP, and DEP led to a greater production of C-reactive protein and IL-6 mRNA. oe-udp 12-18 interleukin 6 Homo sapiens 313-317 33460754-8 2021 RESULTS: MSW reduced the joint swelling rate in gouty arthritis model and inhibited MSU induced up-regulation of IL-1beta, TNF-alpha, and IL-6 protein levels in serum and synovial fluid. Uric Acid 84-87 interleukin 6 Homo sapiens 138-142 16179737-6 2005 Furthermore, AXE attenuated the phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore (A23187)-stimulated tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 secretion in human mast cells. Calcimycin 94-100 interleukin 6 Homo sapiens 157-175 33710470-8 2021 CONCLUSION: Peripheral blood IL-6 and IL-8 levels could play a role in the severity of DME and UME, respectively. dme 87-90 interleukin 6 Homo sapiens 29-33 14656685-0 2003 Ex vivo lipopolysaccharide (LPS)-induced TNF-alpha, IL-1beta, IL-6 and PGE2 secretion in whole blood from Type 1 diabetes mellitus patients with or without aggressive periodontitis. ex vivo lipopolysaccharide 0-26 interleukin 6 Homo sapiens 62-66 12732938-8 2003 Total intracellular PL contents were also unchanged; however, IL-6 led to significant changes in PL composition including an increase in phosphatidylethanolamine (PE) and sphingomyelin (SM) and a decrease in phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) ( p<0.05). Sphingomyelins 171-184 interleukin 6 Homo sapiens 62-66 16308450-4 2005 We have found, that pentazocine, SKF 10 047, dextrorphan reduce spontaneous secretion of IL-8, IL-6 and IL-10 and selectively changes synthesis of IL-4 by Jurkat human T lymphocyte cells lines. Dextrorphan 45-56 interleukin 6 Homo sapiens 95-99 16118799-5 2005 The aims of this study were to determine the effects of statins (atorvastatin and simvastatin) on microglial cells with regard to the secretion of the inflammatory cytokine interleukin-6 (IL-6) and cell viability after activation of the cells with bacterial lipopolysaccharides (LPS) or beta-amyloid1-40 (Abeta1-40) and in unstimulated cells. Simvastatin 82-93 interleukin 6 Homo sapiens 173-186 16118799-8 2005 Both atorvastatin and simvastatin reduced the basal secretion of IL-6 and the cell viability of the microglia, but only atorvastatin reduced LPS- and Abeta1-40-induced IL-6 secretion. Simvastatin 22-33 interleukin 6 Homo sapiens 65-69 15912140-6 2005 Release of IL-6, IL-8 and TNF-alpha was inhibited by 82-93% at 100 microM quercetin and kaempferol, and 31-70% by myricetin and morin. kaempferol 88-98 interleukin 6 Homo sapiens 11-15 12732938-8 2003 Total intracellular PL contents were also unchanged; however, IL-6 led to significant changes in PL composition including an increase in phosphatidylethanolamine (PE) and sphingomyelin (SM) and a decrease in phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) ( p<0.05). Sphingomyelins 186-188 interleukin 6 Homo sapiens 62-66 12782111-11 2003 Although both diamino and carboxyl-SPM groups stimulated increases in IL-6 transcript, only the more electronegatively charged carboxyl-SPM stimulated mRNA-VR1 receptor. diamino 14-21 interleukin 6 Homo sapiens 70-74 33122571-15 2021 The incremental change in surgery-induced IL-6 levels was greater in the TIVA group than DEX-TIVA group (P < 0.0001). dex-tiva 89-97 interleukin 6 Homo sapiens 42-46 12771600-11 2003 The nadir ERMBT result was significantly and negatively correlated with both peak interleukin-6 concentration (r(s) = -.541, p =.03) and log interleukin-6 area under the curve from 0 to 72 hrs (r(s) = -.597, p =.014). ermbt 10-15 interleukin 6 Homo sapiens 82-95 12771600-11 2003 The nadir ERMBT result was significantly and negatively correlated with both peak interleukin-6 concentration (r(s) = -.541, p =.03) and log interleukin-6 area under the curve from 0 to 72 hrs (r(s) = -.597, p =.014). ermbt 10-15 interleukin 6 Homo sapiens 141-154 12771600-12 2003 Subjects with a peak interleukin-6 of >100 pg/mL had a significantly lower nadir ERMBT compared with subjects with a peak interleukin-6 of <100 pg/mL (35.5% +/- 5.2% vs. 74.7% +/- 5.1%, p <.001). ermbt 84-89 interleukin 6 Homo sapiens 21-34 15972472-6 2005 Under conditions of LLO-induced pore formation without extensive cell lysis, Ca2+ influx was observed, and the IL-6 expression induced by rLLO was inhibited by pretreatment with 1,2-bis(2-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid tetrakis(acetoxymethyl ester) (BAPTA-AM), an intracellular Ca2+ chelator. 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 266-274 interleukin 6 Homo sapiens 111-115 33539038-12 2021 According to the cytokine antibody array results, hOBs pretreated with AZA had significantly increased production of several inflammatory cytokines (P<0.05), in which the expression levels of IL-6 and IL-8 were the most dramatically increased upon LTA stimulation (P<0.01). hobs 50-54 interleukin 6 Homo sapiens 192-196 15972472-8 2005 Pretreatment with BAPTA-AM inhibited persistent IL-6 expression in Caco-2 cells infected with wild-type L. monocytogenes. 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 18-26 interleukin 6 Homo sapiens 48-52 12938820-15 2003 Mesothelial cells showed a twofold increase in interleukin (IL)-6 and IL-8 production after exposure to 3-DG. 3-deoxyglucosone 104-108 interleukin 6 Homo sapiens 47-65 33360830-7 2021 In M1 macrophages, cladribine reduced the secretion of IL-6 and TNF-alpha observed after activation with LPS. Cladribine 19-29 interleukin 6 Homo sapiens 55-59 12482878-6 2003 Interleukin-6 and insulin-like growth factor-I, growth and survival factors in multiple myeloma, induce caveolin-1 phosphorylation, which is abrogated by pre-treatment with beta-cyclodextrin. betadex 173-190 interleukin 6 Homo sapiens 0-46 15925303-3 2005 EPA, DHA, and AA have negative feedback control on tumor necrosis factor-alpha and IL-6 synthesis. Eicosapentaenoic Acid 0-3 interleukin 6 Homo sapiens 83-87 15925303-4 2005 Hence, EPA, DHA, and AA deficiencies induced by an energy-dense diet increase generation of tumor necrosis factor-alpha and interleukin-6, markers of inflammation that in turn decrease production of endothelial nitric oxide and adiponectin to induce insulin resistance in maternal and fetal tissues. Eicosapentaenoic Acid 7-10 interleukin 6 Homo sapiens 124-137 33252072-9 2021 RESULTS: reatment of HBMVECs with 30 mM glucose increased thrombin activity and expression of inflammatory proteins TNFalpha, IL-6, and MMPs 2 and 9; this elevation was reduced by the thrombin inhibitor dabigatran. Dabigatran 203-213 interleukin 6 Homo sapiens 126-130 15864048-4 2005 We observed elevation of all three proinflammatory cytokines tested (interleukin-6, interleukin-1, and tumor necrosis factor-alpha) in response to polyethylene particulate challenge when compared with the controls in both patient groups. Polyethylene 147-159 interleukin 6 Homo sapiens 69-82 12848589-2 2003 This profile has been selected from R&D Insight, a pharmaceutical intelligence database produced by Adis International Ltd. CBP 1011 or medroxyprogesterone, is a progesterone agonist and inhibits pro-inflammatory mediators such as interleukin-6 and tumour necrosis factor (TNF). Medroxyprogesterone 140-159 interleukin 6 Homo sapiens 235-248 33249629-2 2021 The anti-inflammatory potential of Naringenin-LCNs evaluated by qPCR revealed a decreased expression of IL-6, IL-8, IL-1beta, and TNF-alpha in lipopolysaccharide-induced BCi-NS1.1 cells. naringenin-lcns 35-50 interleukin 6 Homo sapiens 104-108 12458386-8 2003 Interleukin-6 levels were significantly elevated from 11.28+/-3.4 pg/ml (preischemic) to 109+/-85.9 pg/ml (ischemic) and to 189.33+/-120.24 pg/ml (reperfusion); and tromboxane B(2) levels from 141.57+/-51.20 pg/ml preoperation to 473.01+/-319.01 pg/ml during the surgical procedure. tromboxane b 165-177 interleukin 6 Homo sapiens 0-13 14999424-9 2005 It can be concluded that hyaluronan considerably decreased IL-6 levels, which correlated with clinical improvement, but had no effect on IL-8 and TNF-alpha levels in synovial fluid. Hyaluronic Acid 25-35 interleukin 6 Homo sapiens 59-63 32951223-2 2021 Here, we assessed the relationship between IL-6 variants and serum alpha-tocopherol levels on periodontal condition by considering effect modification. alpha-Tocopherol 67-83 interleukin 6 Homo sapiens 43-47 15946602-12 2005 In addition, GBIT extract inhibited phorbol 12-myristate 13-acetate + A23187-induced interleukin-6 secretion from human mast cell line HMC-1 cells. Calcimycin 70-76 interleukin 6 Homo sapiens 85-98 12629765-0 2003 [Interleukin 6 deduces serum urate concentration]. Uric Acid 29-34 interleukin 6 Homo sapiens 1-14 12509619-8 2003 The inhibition of MMP-1 and IL-6 production was due to the known inhibitory effect of A77 1726 on pyrimidine synthesis, as it was reversed by the addition of uridine. pyrimidine 98-108 interleukin 6 Homo sapiens 28-32 32951223-6 2021 In addition, a significant association was found between the reciprocal number of PRRs of the IL-6 genotype and three serum alpha-tocopherol levels. alpha-Tocopherol 124-140 interleukin 6 Homo sapiens 94-98 12241537-0 2002 Arsenite inhibits interleukin-6 production in human intestinal epithelial cells by down-regulating nuclear factor-kappaB activity. arsenite 0-8 interleukin 6 Homo sapiens 18-31 33394485-0 2021 Impaction of the polylactic membrane or hydrofiber with silver dressings on the interleukin-6, tumor necrosis factor-alpha, transforming growth factor-b3 levels in the blood and tissues of pediatric patients with burns. Silver 56-62 interleukin 6 Homo sapiens 80-93 12241537-2 2002 We tested the hypothesis that sodium arsenite inhibits IL-6 production in stimulated enterocytes and that this effect of arsenite is caused by down-regulation of NF-kappaB activity. arsenite 37-45 interleukin 6 Homo sapiens 55-59 12162776-8 2002 Meloxicam (a specific COX-2 inhibitor) suppressed the induction of cytokines on IL-6 mRNA levels, and these effects could be reversed by exogenous prostaglandin E(2). Meloxicam 0-9 interleukin 6 Homo sapiens 80-84 15728480-5 2005 Cyclosporin A and FK506, which target calcineurin and thereby inhibit TCR-mediated Ca(2+) signal pathways, block IL-6-mediated c-Maf expression. Tacrolimus 18-23 interleukin 6 Homo sapiens 113-117 15673867-6 2005 Lidocaine (0.5 mg/mL) decreased IL-1beta (1.89 +/- 0.11 versus 4.16 +/- 1.27 pg/mL; P = 0.009), IL-6 (65.5 +/- 5.14 versus 162 +/- 11.5 pg/mL; P < 0.001), and IL-8 (3869 +/- 785 versus 14,961 +/- 406 pg/mL; P < 0.001) concentrations compared with the control. Lidocaine 0-9 interleukin 6 Homo sapiens 96-100 12133975-5 2002 PMA plus A23187 or IgE plus anti-IgE induced the production of IL-8 and GM-CSF in supernatants of HMC-1 cells and IL-4 and IL-6 in supernatants of KU812 cells. Calcimycin 9-15 interleukin 6 Homo sapiens 123-127 33394485-1 2021 BACKGROUND: We aimed to evaluate the effects of two different burn dressings, hydrofiber with a silver (HFAg) and polylactic membrane (PLM), on altering the levels of important biomarkers Interleukin-6 (IL-6), Tumor necrosis factor-alpha (TNF-alpha), Transforming growth factor-beta3 (TGF-beta3) in blood and burnt tissue in children with second-degree burns. Silver 96-102 interleukin 6 Homo sapiens 188-201 32896803-10 2020 CONCLUSIONS: These results suggest that IL-6 trajectories of CAP patients are associated with age and run parallel to bilirubin levels. Bilirubin 118-127 interleukin 6 Homo sapiens 40-44 12143206-5 2002 The increase in portal interleukin-6 levels during liver resection (time points, ii and iii) significantly correlated with the duration of hepatic inflow occlusion (48 +/- 9 min, mean +/- SD), portal venous pressure (500 +/- 127 mmH2O), and postoperative serum levels of transaminases (day 1; S-ALT, 705 +/- 1023 U/L; S-AST 892 +/- 1255 U/L) and maximum bilirubin (2.6 +/- 2.5 mg/dL). Bilirubin 354-363 interleukin 6 Homo sapiens 23-36 15620577-5 2005 Luteolin, the deglycosylated derivative of one of the major compositions, luteolin-7-glucoside, exerted inhibitory effects on TNF-alpha, IL-6 and IFN-gamma production in activated human whole blood with estimated IC(50)s of 42.73 microM, 44.86 microM and 3.34 microM, respectively. luteolin-7-glucoside 74-94 interleukin 6 Homo sapiens 137-141 15582581-6 2005 The pretreatment of SaM-1 cells with suramin or 2-APB also inhibited the increase in IL-6 synthesis in response to ATP. Suramin 37-44 interleukin 6 Homo sapiens 85-89 33193842-6 2020 The present study evaluated the capability of DOACs in reducing plasma level of IL-6 in patients suffered from deep vein thrombosis (DVT) of the lower limbs. doacs 46-51 interleukin 6 Homo sapiens 80-84 15618130-9 2005 Furthermore, AIE decreased the phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated tumor necrosis factor-alpha and interleukin-6 gene expression and production in human mast cells. Calcimycin 92-98 interleukin 6 Homo sapiens 142-155 15753145-8 2004 alpha-Tocopherol therapy, especially at high doses, has been shown to decrease release of pro-inflammatory cytokines (such as interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha) and the chemokine interleukin-8, and to decrease adhesion of monocytes to endothelium. alpha-Tocopherol 0-16 interleukin 6 Homo sapiens 145-191 12137744-5 2002 The inhibitors SB203580, PD98059, SN50, cycloheximide and D-ribofuranosylbenzimidazole each reduced the basal and TNFalpha-stimulated secretion of IL-1beta and also reduced IL-6 secretion with the exception of SN50. D-ribofuranosylbenzimidazole 58-86 interleukin 6 Homo sapiens 173-177 12173196-0 2002 Differential modulation of interleukin-6 and interleukin-10 by diclofenac in patients undergoing major surgery. Diclofenac 63-73 interleukin 6 Homo sapiens 27-40 12173196-3 2002 We hypothesized that diclofenac would affect release of IL-6 and IL-10 and modulate the immune response. Diclofenac 21-31 interleukin 6 Homo sapiens 56-60 33193842-8 2020 We postulate that lowered IL-6 expression in the lymphocytes of DVT patients may mediate the anti-inflammatory action of DOACs. doacs 121-126 interleukin 6 Homo sapiens 26-30 12173196-10 2002 At 12 h, the IL-6 concentration was significantly lower in patients receiving diclofenac than in those receiving placebo (P = 0.003). Diclofenac 78-88 interleukin 6 Homo sapiens 13-17 33496116-9 2020 The results of molecular docking showed that baicalein,berberine,licochalcone A and 6-gingerol had a high affinity with SRC,STAT3,TNF and IL6. gingerol 84-94 interleukin 6 Homo sapiens 138-141 12173196-13 2002 Cortisol concentration correlated with IL-6 concentration at 24 h. CONCLUSIONS: Administration of diclofenac was associated with lower IL-6 and higher IL-10 concentrations, and lower leucocyte count, C-reactive protein concentration and temperature. Diclofenac 98-108 interleukin 6 Homo sapiens 39-43 12173196-13 2002 Cortisol concentration correlated with IL-6 concentration at 24 h. CONCLUSIONS: Administration of diclofenac was associated with lower IL-6 and higher IL-10 concentrations, and lower leucocyte count, C-reactive protein concentration and temperature. Diclofenac 98-108 interleukin 6 Homo sapiens 135-139 15654514-4 2004 RESULTS: HMC-1 produced substantial amounts of GM-CSF and IL-8 and smaller amounts of TNF-alpha, IL-4 and IL-6 after being stimulated with PMA together with A23187. Calcimycin 157-163 interleukin 6 Homo sapiens 106-110 15619425-7 2004 The treatment of cytochalasin D, which effectively inhibited invasion of L. pneumophila into A549, significantly reduced the production of IL-6 and TNF-alpha, but not IL-8. Cytochalasin D 17-31 interleukin 6 Homo sapiens 139-143 33324265-5 2020 Results: The results showed that schizophrenia patients treated with olanzapine or clozapine (both MetS and non-MetS groups) had significantly higher plasma levels of IL-6, IL-10, and TNF-alpha compared to normal controls (all P < 0.05). Olanzapine 69-79 interleukin 6 Homo sapiens 167-171 15251176-9 2004 When cells exposed to 200 microM SM were treated with the p38 MAP kinase inhibitor SB203580, the levels of IL-8, IL-6, and TNF-alpha and IL-1beta were significantly decreased when compared with cells that were untreated. Samarium 33-35 interleukin 6 Homo sapiens 113-117 11994489-7 2002 MSUM- or CPPD-stimulated expression of IL-6 in hOB pretreated with the selective cyclooxygenase-2 inhibitor NS-398 was increased, unlike that induced by IL-1 alone which was partially reduced. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 108-114 interleukin 6 Homo sapiens 39-43 11849244-1 2002 OBJECTIVE: Current thinking is that amiodarone-induced thyrotoxicosis (AIT) might be either iodine-induced thyrotoxicosis in latent hyperthyroidism (Type 1) or destructive thyroiditis (Type 2), and also that colour-flow Doppler sonography (CFDS) of the thyroid and serum interleukin 6 (IL-6) are tools that can classify AIT and direct treatment. Iodine 92-98 interleukin 6 Homo sapiens 271-284 31504866-11 2020 IL-6 concentrations at six hours were lower in lidocaine patients when compared with controls. Lidocaine 47-56 interleukin 6 Homo sapiens 0-4 11849244-1 2002 OBJECTIVE: Current thinking is that amiodarone-induced thyrotoxicosis (AIT) might be either iodine-induced thyrotoxicosis in latent hyperthyroidism (Type 1) or destructive thyroiditis (Type 2), and also that colour-flow Doppler sonography (CFDS) of the thyroid and serum interleukin 6 (IL-6) are tools that can classify AIT and direct treatment. Iodine 92-98 interleukin 6 Homo sapiens 286-290 11766169-6 2001 Four other 8-ketotrichothecenes, fusarenon X, nivalenol, 3-acetyl DON, and 15-acetyl DON, were also capable of upregulating or suppressing TNF-alpha, IL-6, and IL-8 production at concentrations similar to that of DON. 3-Acetyldeoxynivalenol 57-69 interleukin 6 Homo sapiens 150-154 15362934-0 2004 Influence of eicosapentaenoic acid, an omega-3 fatty acid, on ultraviolet-B generation of prostaglandin-E2 and proinflammatory cytokines interleukin-1 beta, tumor necrosis factor-alpha, interleukin-6 and interleukin-8 in human skin in vivo. Eicosapentaenoic Acid 13-34 interleukin 6 Homo sapiens 186-199 15273083-5 2004 Serum TNF-alpha and IL-6 levels at 24 and 48 h were significantly lower in the ciprofloxacin group, while the IL-10/TNF-alpha ratio was significantly higher, than those for the ceftazidime group. Ciprofloxacin 79-92 interleukin 6 Homo sapiens 20-24 11556519-8 2001 RESULTS: We have demonstrated that aceclofenac, 4"-hydroxyaceclofenac and diclofenac significantly decreased interleukin-6 production at concentrations ranged among 1 to 30 microM and fully blocked prostaglandin E2 synthesis by IL-1beta- or LPS-stimulated human chondrocytes. Diclofenac 74-84 interleukin 6 Homo sapiens 109-122 11357886-0 2001 Effects of FK506 and other immunosuppressive anti-rheumatic agents on T cell activation mediated IL-6 and IgM production in vitro. Tacrolimus 11-16 interleukin 6 Homo sapiens 97-101 33251227-16 2020 In multiple linear regression analysis, both peak IL-6 (p = 0.002) and IL-8 (p = 0.01) concentrations remained significantly correlated with GFRiohexol, without collinearity. gfriohexol 141-151 interleukin 6 Homo sapiens 50-54 11345198-10 2001 However, the increase in PDGF-stimulated CFU-GM proliferation was inhibited by anti-GM-CSF, anti-IL-3, and anti-IL-6 antibodies (n = 4), suggesting that endogenously produced GM-CSF, IL-3, and IL-6 may play a role in the PDGF-induced CFU-GM proliferation. cfu-gm 41-47 interleukin 6 Homo sapiens 112-116 11345198-10 2001 However, the increase in PDGF-stimulated CFU-GM proliferation was inhibited by anti-GM-CSF, anti-IL-3, and anti-IL-6 antibodies (n = 4), suggesting that endogenously produced GM-CSF, IL-3, and IL-6 may play a role in the PDGF-induced CFU-GM proliferation. cfu-gm 41-47 interleukin 6 Homo sapiens 193-197 15303261-3 2004 [3H]SP binding experiments in parallel on the same intact cells indicate that hyperforin-DCHA does not interact with neuro-kinin-I receptors but very likely interacts with some intracellular steps leading to the synthesis and/or release of IL6. dicyclohexylamine 89-93 interleukin 6 Homo sapiens 240-243 15194822-7 2004 We also found that 10 microM ATP gamma S increased transcription of IL-6 approximately 40-fold within 2 h. This effect was abolished by blockade of P2Y receptors with 100 microM suramin. Suramin 178-185 interleukin 6 Homo sapiens 68-72 33140671-14 2022 Additionally, TET promoted macrophage transformation from M1 to M2 in osteoporotic and inhibited the production of IL-1beta, TNF-alpha, and IL-6. tetrandrine 14-17 interleukin 6 Homo sapiens 140-144 15118463-7 2004 RESULTS: Latanoprost, pilocarpine-HCl, and timolol-maleate increased IL-6 levels in the conditioned medium in a dilution factor-dependent manner (P < 0.05, ANOVA). Latanoprost 9-20 interleukin 6 Homo sapiens 69-73 15118463-8 2004 IL-6 concentrations were increased most significantly by latanoprost and were (pg/ml; mean +/- SEM; N = 3 cultures) 186 +/- 37, 187 +/- 33, 295 +/- 46 and 336 +/- 76 in cultures treated at 1:400, 1:250, 1:150, and 1:100 dilutions, respectively, whereas those of six control cultures averaged 80 +/- 9. Latanoprost 57-68 interleukin 6 Homo sapiens 0-4 11327082-9 2001 TMB-8 significantly suppressed PGF2alpha-induced IL-6 production, whereas calphostin C showed a stimulatory effect on PGF2alpha-induced IL-6 production. Dinoprost 118-127 interleukin 6 Homo sapiens 136-140 11327082-10 2001 From these data, we suggest that PGF2alpha upregulates IL-6 production through FP receptors in HGF, that PGF2alpha synergistically enhances IL-6 production in IL-1beta- and TNFalpha-stimulated HGF, and that PGF2alpha-induced IL-6 production may be dependent on intracellular Ca2+ mobilization and be downregulated by PKC activation. Dinoprost 33-42 interleukin 6 Homo sapiens 55-59 11327082-10 2001 From these data, we suggest that PGF2alpha upregulates IL-6 production through FP receptors in HGF, that PGF2alpha synergistically enhances IL-6 production in IL-1beta- and TNFalpha-stimulated HGF, and that PGF2alpha-induced IL-6 production may be dependent on intracellular Ca2+ mobilization and be downregulated by PKC activation. Dinoprost 105-114 interleukin 6 Homo sapiens 140-144 11327082-10 2001 From these data, we suggest that PGF2alpha upregulates IL-6 production through FP receptors in HGF, that PGF2alpha synergistically enhances IL-6 production in IL-1beta- and TNFalpha-stimulated HGF, and that PGF2alpha-induced IL-6 production may be dependent on intracellular Ca2+ mobilization and be downregulated by PKC activation. Dinoprost 105-114 interleukin 6 Homo sapiens 140-144 11327082-10 2001 From these data, we suggest that PGF2alpha upregulates IL-6 production through FP receptors in HGF, that PGF2alpha synergistically enhances IL-6 production in IL-1beta- and TNFalpha-stimulated HGF, and that PGF2alpha-induced IL-6 production may be dependent on intracellular Ca2+ mobilization and be downregulated by PKC activation. Dinoprost 105-114 interleukin 6 Homo sapiens 140-144 11327082-10 2001 From these data, we suggest that PGF2alpha upregulates IL-6 production through FP receptors in HGF, that PGF2alpha synergistically enhances IL-6 production in IL-1beta- and TNFalpha-stimulated HGF, and that PGF2alpha-induced IL-6 production may be dependent on intracellular Ca2+ mobilization and be downregulated by PKC activation. Dinoprost 105-114 interleukin 6 Homo sapiens 140-144 11327082-11 2001 PGF2alpha may be involved in the pathogenesis of periodontal disease by enhancing IL-6 levels in periodontal lesions. Dinoprost 0-9 interleukin 6 Homo sapiens 82-86 15135888-4 2004 Treatment with IL-1alpha or IL-6 caused a dose-dependent increase in survival as measured by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. thiazolyl blue 97-158 interleukin 6 Homo sapiens 28-32 32603665-12 2020 Altogether, our findings illustrated TNBC-activated macrophages conferred TNBC cells resistance to BETi via IL-6 or IL-10/STAT3/IKBKE/NF-kappaB axis. beti 99-103 interleukin 6 Homo sapiens 108-112 15209363-6 2004 IJAE inhibited the secretion of tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated human mast cell line (HMC-1) cells. Calcimycin 159-165 interleukin 6 Homo sapiens 76-94 32162041-11 2020 CONCLUSION: Vitamin C supplementation attenuates the oxidative stress (lipid peroxidation) and inflammatory response (IL-6) to a single bout of exercise. Ascorbic Acid 12-21 interleukin 6 Homo sapiens 118-122 14717786-9 2004 In conclusion, SelCIDs can exert their anti-myeloma activity through two mechanisms, i.e. inhibition of VEGF and IL-6 production by interacting myeloma and endothelium and induction of myeloma cell apoptosis. selcids 15-22 interleukin 6 Homo sapiens 113-117 11048965-0 2000 Effect of phenytoin on the production of interleukin-6 and interleukin-8 in human gingival fibroblasts. Phenytoin 10-19 interleukin 6 Homo sapiens 41-54 11048965-1 2000 The in vitro effect of phenytoin (PHT) on the production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in human gingival fibroblasts, challenged with or without interleukin-1beta (IL-1beta), was studied. Phenytoin 23-32 interleukin 6 Homo sapiens 60-73 11048965-1 2000 The in vitro effect of phenytoin (PHT) on the production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in human gingival fibroblasts, challenged with or without interleukin-1beta (IL-1beta), was studied. Phenytoin 23-32 interleukin 6 Homo sapiens 75-79 11048965-1 2000 The in vitro effect of phenytoin (PHT) on the production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in human gingival fibroblasts, challenged with or without interleukin-1beta (IL-1beta), was studied. Phenytoin 34-37 interleukin 6 Homo sapiens 60-73 11048965-1 2000 The in vitro effect of phenytoin (PHT) on the production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in human gingival fibroblasts, challenged with or without interleukin-1beta (IL-1beta), was studied. Phenytoin 34-37 interleukin 6 Homo sapiens 75-79 11048965-3 2000 The stimulatory effect of PHT on IL-1beta-induced IL-6 production was strongly reduced by the specific cyclooxygenase-2 inhibitor NS-398 (1 microM). N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 130-136 interleukin 6 Homo sapiens 50-54 11048965-4 2000 The anti-inflammatory drug, dexamethasone (1 microM), abolished the production of both IL-6 and IL-8 in gingival fibroblasts challenged with PHT in the presence or absence of IL-1beta. Phenytoin 141-144 interleukin 6 Homo sapiens 87-91 11037761-8 2000 Nontoxic TEGDMA concentrations induced IL-6 levels 5-fold, but IL-8 amounts increased only slightly. triethylene glycol dimethacrylate 9-15 interleukin 6 Homo sapiens 39-43 10994781-9 2000 The administration of both IL-6 and GM-CSF induced cell-proliferation activities estimated by both [3H]-thymidine and bromodeoxyuridine labeling. Bromodeoxyuridine 118-135 interleukin 6 Homo sapiens 27-31 14747392-5 2004 tHcy had weak to moderate but statistically significant bivariate and multivariate correlations with some laboratory markers of nutrition (serum albumin, prealbumin, creatinine, and urea nitrogen) but no significant correlation with serum C-reactive protein or two proinflammatory cytokines (IL-6 and TNF-alpha). thcy 0-4 interleukin 6 Homo sapiens 292-296 12855406-6 2004 NECA increased the release of interleukin-6 and monocyte chemotactic protein-1 proteins with EC50 values of 1.26 +/- 0.25 microM and 0.40 +/- 0.08 microM, respectively, and the maximal folds of induction were 20.8 +/- 1.7- and 6.4 +/- 0.7-fold, respectively. Adenosine-5'-(N-ethylcarboxamide) 0-4 interleukin 6 Homo sapiens 30-43 32533519-0 2020 Assessment of the Effect of Perioperative Venous Lidocaine on the Intensity of Pain and IL-6 Concentration After Laparoscopic Gastroplasty. Lidocaine 49-58 interleukin 6 Homo sapiens 88-92 15050096-6 2004 In our recent study, the results demonstrate that monocytes exhibit an enhanced production of interleukin-6 (IL-6) in response to CRP, and this response is significantly inhibited by simvastatin in a dose-dependent manner. Simvastatin 183-194 interleukin 6 Homo sapiens 94-107 15050096-6 2004 In our recent study, the results demonstrate that monocytes exhibit an enhanced production of interleukin-6 (IL-6) in response to CRP, and this response is significantly inhibited by simvastatin in a dose-dependent manner. Simvastatin 183-194 interleukin 6 Homo sapiens 109-113 14533000-10 2003 Serum IL-6 levels were significantly higher in the n-6 fatty acid-rich diet group than in the n-3 fatty acid-rich group (P<0.05). Fatty Acids, Omega-6 51-65 interleukin 6 Homo sapiens 6-10 12901869-6 2003 Two NF-kappaB inhibitors, pyrrolidine dithiocarbamanate (PDTC) and SN50, or antisense oligodeoxynucleotides for NF-kappaB p65 and p50 suppressed IL-6 mRNA expressions induced by continuous stretch. pyrrolidine dithiocarbamanate 26-55 interleukin 6 Homo sapiens 145-149 11028561-11 2000 Geldanamycin, which has been shown in studies to inhibit AP-1 activation, blocked IL-1beta-induced AP-1 luciferase gene activation and IL-6 production. geldanamycin 0-12 interleukin 6 Homo sapiens 135-139 10920220-5 2000 Pretreatment of MG-63 cells with cytochalasin B prevented the particle-induced increase of IL-6 expression but did not alter the basal level of IL-6 release from cells cultured in the absence of particles. Cytochalasin B 33-47 interleukin 6 Homo sapiens 91-95 32973190-10 2020 In human corneal epithelial cells, secretion of IL-6 and IL-8 in both apical and basolateral media was promoted significantly by perfluorooctanoic acid treatment. perfluorooctanoic acid 129-151 interleukin 6 Homo sapiens 48-52 10770757-3 2000 In this study, AG7088 was tested for its antiviral activity and ability to inhibit the production of IL-6 and IL-8 in a human bronchial epithelial cell line, BEAS-2B. rupintrivir 15-21 interleukin 6 Homo sapiens 101-105 10770757-5 2000 Treatment of HRV 14-infected cells with AG7088 resulted in a statistically significant (P, <0.05) dose-dependent reduction in the levels of infectious virus as well as IL-6 and IL-8 released into the cell supernatant compared to the results obtained for compound-free infected cells. rupintrivir 40-46 interleukin 6 Homo sapiens 171-175 10770757-7 2000 In time-of-addition studies, AG7088 could be added as late as 14 to 26 h after HRV 14 infection of BEAS-2B cells and still result in a statistically significant (P, <0.05) reduction in the levels of infectious virus, IL-6, and IL-8 compared to the results obtained for compound-free infected cells. rupintrivir 29-35 interleukin 6 Homo sapiens 220-224 12913930-2 2003 From an observation that gold sodium thiomalate (GSTM) induces monocyte-derived interleukin 6 (IL-6) and IL-10 production in vitro, a hypothesis has been proposed that gold exerts its action mainly as a selective immunostimulator rather than as a general immunosuppressant. Gold Sodium Thiomalate 49-53 interleukin 6 Homo sapiens 80-93 12913930-2 2003 From an observation that gold sodium thiomalate (GSTM) induces monocyte-derived interleukin 6 (IL-6) and IL-10 production in vitro, a hypothesis has been proposed that gold exerts its action mainly as a selective immunostimulator rather than as a general immunosuppressant. Gold Sodium Thiomalate 49-53 interleukin 6 Homo sapiens 95-99 32794529-8 2020 Moreover, as compared to the control group, sows and newborn piglets in the Na2SeO3 and HMSeBA groups had a lower serum interleukin-6 (p < 0.05) concentration, and placentas in the HMSeBA group had lower IL-1beta, IL-6 and IL-8 gene expression (p < 0.05). na2seo3 76-83 interleukin 6 Homo sapiens 120-133 12791215-2 2003 Histamine, released from the conjunctival mast cells, might stimulate the synthesis of proinflammatory molecules such as IL-6 and IL-8 by the epithelial cells through the receptors that couple to inositol phosphate generation and, therefore, amplify the allergic response. Inositol Phosphates 196-214 interleukin 6 Homo sapiens 121-125 12832326-7 2003 Cell culture studies found that exogenous addition of the ketone body AA, but not BHB, increases IL-6 secretion and ROS generation in U937 cells. Ketones 58-64 interleukin 6 Homo sapiens 97-101 10803780-16 2000 IL-6 was correlated positively with white blood cell and neutrophil counts, C-reactive protein, and serum total bilirubin and negatively with hepaplastin test and serum total protein levels. Bilirubin 112-121 interleukin 6 Homo sapiens 0-4 10602388-0 1999 Fluoride-induced interleukin-6 and interleukin-8 synthesis in human epithelial lung cells. Fluorides 0-8 interleukin 6 Homo sapiens 17-30 32794529-8 2020 Moreover, as compared to the control group, sows and newborn piglets in the Na2SeO3 and HMSeBA groups had a lower serum interleukin-6 (p < 0.05) concentration, and placentas in the HMSeBA group had lower IL-1beta, IL-6 and IL-8 gene expression (p < 0.05). na2seo3 76-83 interleukin 6 Homo sapiens 214-218 10602388-8 1999 The fluoride-induced effects on IL-6 and IL-8 release were strongly reduced by pretreatment with deferoxamine (an Al3+-chelator), and enhanced by addition of Al3+. Fluorides 4-12 interleukin 6 Homo sapiens 32-36 12796255-7 2003 Secretions of PGE2, IL-1alpha, and IL-6 at x10 dilutions of latanoprost or timolol were 3 to 77 times higher than in controls, whereas they were 190 to 305 times higher at a x180 dilution of benzalkonium chloride. Latanoprost 60-71 interleukin 6 Homo sapiens 35-39 10602388-9 1999 This indicates that an AlF4-- complex, a known activator of GTP-binding proteins, is involved in fluoride-induced IL-6 and IL-8 responses in A549 cells. Fluorides 97-105 interleukin 6 Homo sapiens 114-118 32912236-5 2020 CdSe-QDs with sharp and tunable emission bands were used to simultaneously quantify CRP and IL-6 in a single test line, by using a single UV-light source and two suitable emission filters for readout through a widely available BioImager device. cdse-qds 0-8 interleukin 6 Homo sapiens 92-96 10598882-5 1999 Hypothemycin also inhibited IL-6, IL-10, IFN-gamma and TNF-alpha production. hypothemycin 0-12 interleukin 6 Homo sapiens 28-32 32878792-1 2020 BACKGROUND/AIM: Eicosapentaenoic acid (EPA) inhibits NF-kB activation and IL-6 production in TE-1 esophageal cancer cells. Eicosapentaenoic Acid 16-37 interleukin 6 Homo sapiens 74-78 10628337-5 1999 In contrast, VAL extracts did not result in an upregulation of activation markers or proliferation of B-CLL cells but induced both, cell death via apoptosis and IL-6 release. Valine 13-16 interleukin 6 Homo sapiens 161-165 12798656-3 2003 Both animal and human studies have indicated that an increased intake of n-6 fatty acids from vegetable oils elevates prostaglandin E(2) levels as well as pro-inflammatory cytokines such as IL-1, IL-6 and TNF-alpha. Fatty Acids, Omega-6 73-88 interleukin 6 Homo sapiens 196-200 12720588-12 2003 The threshold of EPA+DHA intake that results in decreased IL-6 production is between 0.44 and 0.94 g/d. Eicosapentaenoic Acid 17-20 interleukin 6 Homo sapiens 58-62 12716789-5 2003 RESULTS: The percentage of saturated FAs (r = 0.30, P = 0.01) and omega-6 FAs (r = -0.32, P = 0.001) were significantly associated with circulating IL-6, whereas the percentage of omega-3 FAs correlated negatively with C-reactive protein in overweight subjects (P = 0.04). Fatty Acids, Omega-6 66-77 interleukin 6 Homo sapiens 148-152 10479406-5 1999 IL-6 mRNA accumulation in livers and spleens was increased at 4 h following LEH injection and had declined by 24 h. In the liver, cells expressing IL-6 mRNA were located in endothelia of hepatic and portal veins, and hepatic sinuses, Kupffer cells and epithelial cells of bile ducts. LEH 76-79 interleukin 6 Homo sapiens 0-4 32878792-1 2020 BACKGROUND/AIM: Eicosapentaenoic acid (EPA) inhibits NF-kB activation and IL-6 production in TE-1 esophageal cancer cells. Eicosapentaenoic Acid 39-42 interleukin 6 Homo sapiens 74-78 10479406-5 1999 IL-6 mRNA accumulation in livers and spleens was increased at 4 h following LEH injection and had declined by 24 h. In the liver, cells expressing IL-6 mRNA were located in endothelia of hepatic and portal veins, and hepatic sinuses, Kupffer cells and epithelial cells of bile ducts. LEH 76-79 interleukin 6 Homo sapiens 147-151 10479406-8 1999 The data suggest that cells of the reticuloendothelial system (RES) might be a significant source of increased plasma IL-6 in vivo after LEH administration. LEH 137-140 interleukin 6 Homo sapiens 118-122 12533503-5 2003 Plasma glucose and insulin were higher, and cortisol, IL-6, IL-10, and IL-1ra, but not IL-8, were significantly lower postexercise in CHO vs. Pla. CAV protocol 134-137 interleukin 6 Homo sapiens 54-58 33164356-4 2020 The results showed that adenosine, epigoitrin, chlorogenic acid, caffeic acid, cichoric acid, corynoline, baicalin, wogonoside, wogonin and oroxylin A had a certain regulatory effect on inflammatory factor tumor necrosis factor(TNF-alpha), interleukin(IL-1beta) and IL-6 at specific concentrations in a dose-dependent manner. baicalin 106-114 interleukin 6 Homo sapiens 266-270 12533503-10 2003 CHO compared with Pla beverage ingestion attenuates the increase in plasma IL-6, IL-10, and IL-1ra and gene expression for IL-6 and IL-8 in athletes running 3 h at 70% Vo(2 max) despite no differences in muscle glycogen content. CAV protocol 0-3 interleukin 6 Homo sapiens 75-79 12533503-10 2003 CHO compared with Pla beverage ingestion attenuates the increase in plasma IL-6, IL-10, and IL-1ra and gene expression for IL-6 and IL-8 in athletes running 3 h at 70% Vo(2 max) despite no differences in muscle glycogen content. CAV protocol 0-3 interleukin 6 Homo sapiens 123-127 10467171-6 1999 Actinomycin D, cycloheximide, indomethacin, and NS-398 (COX-2 inhibitor) suppressed the production of IL-6 and PGE(2). N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 48-54 interleukin 6 Homo sapiens 102-106 32786865-5 2020 Cytokines IL-8 and IL-6, production was significantly reduced by 40% and 51%, respectively with 1 mM pre-treatment of gamma-EV. gamma-ev 118-126 interleukin 6 Homo sapiens 19-23 10496308-5 1999 Heparan sulfate triggered up-regulation of ICAM-1 and I-A, caused the release by antigen-presenting cells of interleukin (IL)-1, IL-6, tumor necrosis factor, IL-12, transforming growth factor beta, and prostaglandin E2 (PGE2), and (in macrophages) induced cytotoxic capability. Heparitin Sulfate 0-15 interleukin 6 Homo sapiens 129-133 10469353-4 1999 METHODS: IL-6 protein, mRNA, and promoter activity were measured in these cells exposed to LPS (1 microg/ml) and/or terbutaline (10(-9) to 10(-6) M). Terbutaline 116-127 interleukin 6 Homo sapiens 9-13 12703883-15 2003 AoPWV correlated with serum IL-6 and plasma bFGF (R = 0.32, p < 0.05 and R = 0.4, p < 0.01; respectively). aopwv 0-5 interleukin 6 Homo sapiens 28-32 32418888-5 2020 We discovered that PCCs secrete CCL3 and stimulate IL-6, CCL2, ICAM-1 and VCAM-1 expression in MSCs and that the MSC-PCC crosstalk can be disrupted by the lipid-lowering drug simvastatin, which displays pleiotropic effects on cell metabolism and suppresses IL-6 and CCL2 production by MSCs and CCL3 secretion by PCCs. Simvastatin 175-186 interleukin 6 Homo sapiens 51-55 12629105-0 2003 Diminished interleukin-6 response to proinflammatory challenge in men and women after intravenous cocaine administration. Cocaine 98-105 interleukin 6 Homo sapiens 11-24 12629105-8 2003 Stimulation of IL-6 at 240 min was markedly reduced in subjects receiving cocaine compared with subjects receiving placebo (3.85 +/- 0.49 vs. 11.64 +/- 2.21 pg/ml; P = 0.0019, by two-tailed t test). Cocaine 74-81 interleukin 6 Homo sapiens 15-19 12629105-11 2003 Cocaine-induced suppression of proinflammatory IL-6 may mediate impaired host defenses to infections. Cocaine 0-7 interleukin 6 Homo sapiens 47-51 10469353-6 1999 RESULTS: Terbutaline at high concentrations (10(-6) M) significantly up-regulated IL-6 by approximately 25% (P<0.05), whereas at a lower concentration (10(-8) M), it down-regulated IL-6 production by 42% (P<0.05). Terbutaline 9-20 interleukin 6 Homo sapiens 82-86 10469353-6 1999 RESULTS: Terbutaline at high concentrations (10(-6) M) significantly up-regulated IL-6 by approximately 25% (P<0.05), whereas at a lower concentration (10(-8) M), it down-regulated IL-6 production by 42% (P<0.05). Terbutaline 9-20 interleukin 6 Homo sapiens 184-188 10469353-10 1999 The terbutaline-induced down-regulation of IL-6 gene production was mediated by an inhibitory effect of terbutaline on TNF-alpha, which was exerted through the MAPK and cAMP pathways, whereas the up-regulation appeared to be due to a direct action of intracellular cAMP. Terbutaline 4-15 interleukin 6 Homo sapiens 43-47 10469353-10 1999 The terbutaline-induced down-regulation of IL-6 gene production was mediated by an inhibitory effect of terbutaline on TNF-alpha, which was exerted through the MAPK and cAMP pathways, whereas the up-regulation appeared to be due to a direct action of intracellular cAMP. Terbutaline 104-115 interleukin 6 Homo sapiens 43-47 10401557-15 1999 The ODQ potentiated hyperalgesia induced by carrageenan, bradykinin, TNF alpha, IL-1 beta, IL-6 and IL-8. 1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one 4-7 interleukin 6 Homo sapiens 91-95 32418888-5 2020 We discovered that PCCs secrete CCL3 and stimulate IL-6, CCL2, ICAM-1 and VCAM-1 expression in MSCs and that the MSC-PCC crosstalk can be disrupted by the lipid-lowering drug simvastatin, which displays pleiotropic effects on cell metabolism and suppresses IL-6 and CCL2 production by MSCs and CCL3 secretion by PCCs. Simvastatin 175-186 interleukin 6 Homo sapiens 257-261 12559950-3 2003 Here we demonstrate that IL-6-induced gene expression was suppressed by a specific heat-shock protein 90 (Hsp90) inhibitor, geldanamycin (GA) in human hepatoma Hep3B cells. geldanamycin 124-136 interleukin 6 Homo sapiens 25-29 12559950-3 2003 Here we demonstrate that IL-6-induced gene expression was suppressed by a specific heat-shock protein 90 (Hsp90) inhibitor, geldanamycin (GA) in human hepatoma Hep3B cells. geldanamycin 138-140 interleukin 6 Homo sapiens 25-29 32774415-11 2020 The systematical analysis showed that various active compounds of JPFR were closely connected with Wnt/beta-catenin, EGFR, HIF-1, TGFbeta/Smads, and IL6-STAT3 signaling pathway, including kaempferol, isorhamnetin, calycosin, quercetin, medicarpin, phaseol, spinasterol, hederagenin, beta-sitosterol, wighteone, luteolin, and isotrifoliol. kaempferol 188-198 interleukin 6 Homo sapiens 149-152 12559950-4 2003 GA also suppressed the IL-6-induced activation of signal transducer and activator of transcription 3 (STAT3) in a human embryonic kidney carcinoma 293T cells. geldanamycin 0-2 interleukin 6 Homo sapiens 23-27 12559950-6 2003 Furthermore, Hsp90 directly bound to STAT3 via its N-terminal region, which interacted with GA. We provide evidence that the action of GA on IL-6 functions was due to the inhibition of direct physical interactions between STAT3 and Hsp90, which represents a novel role of Hsp90 in the IL-6 signaling pathways. geldanamycin 92-94 interleukin 6 Homo sapiens 141-145 12608645-8 2003 Reduction in prostanoid levels by NS-398 was accompanied by a reduction in IL-6 secretion levels triggered by CD40 ligation. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 34-40 interleukin 6 Homo sapiens 75-79 10446754-4 1999 Mesoporphyrin inhibited interleukin-6 production by human osteoblast-like MG-63 cells. mesoporphyrin IX 0-13 interleukin 6 Homo sapiens 24-37 10211881-10 1999 In animals treated with AdvIL-10, the MMP-3-TIMP-1 balance was partially restored, independent of the effect on mRNA expression of tumor necrosis factor a, IL-1, IL-6, or IL-8. advil-10 24-32 interleukin 6 Homo sapiens 162-166 12620382-15 2003 In vitro study showed that rSLY triggered TNFalpha production by human monocytes and IL-6 production by pig pulmonary alveolar macrophages and monocytes. rsly 27-31 interleukin 6 Homo sapiens 85-89 10342040-1 1999 OBJECTIVES: The aim of this study was to investigate the effects of two nonsteroidal anti-inflammatory drugs (NSAIDs), nimesulide and sodium diclofenac, on the production of proteoglycans (PG), prostaglandin E2 (PGE2) and cytokines (IL-6 and IL-8) by human articular chondrocytes in vitro. Diclofenac 134-151 interleukin 6 Homo sapiens 233-237 32746565-7 2020 Compared with the control group, the secretion levels of IL-6 were decreased in the 0.01, 0.1 and 1.0 mg/L PFOS groups (P<0.05) , the concentrations of TNF-alpha were increased in the 0.01 and 1.0 mg/L PFOS groups (P<0.05) , and the concentrations of IL-10 were increased in the 0.1 and 1.0 mg/L PFOS groups (P<0.05) . perfluorooctane sulfonic acid 107-111 interleukin 6 Homo sapiens 57-61 10342040-14 1999 Furthermore, both nimesulide and diclofenac at therapeutic concentrations significantly decreased spontaneous and IL-1 beta-stimulated IL-6 production by human chondrocytes, but did not modify IL-8 production. Diclofenac 33-43 interleukin 6 Homo sapiens 135-139 10342040-15 1999 CONCLUSION: From the results of this study we conclude that nimesulide and diclofenac at therapeutic concentrations are potent inhibitors of PGE2 and IL-6 production while they do not modify proteoglycan or IL-8 production. Diclofenac 75-85 interleukin 6 Homo sapiens 150-154 10213368-11 1999 Microparticles prepared from either chitosan or starch microparticles, applied apically, induced the basolateral release of IL-6 and IL-8 from polarized Calu-3 cells. Chitosan 36-44 interleukin 6 Homo sapiens 124-128 12143044-6 2002 The cPLA(2) inhibitor arachidonyl fluorophosphonate (MAFP) and the COX-2 inhibitor NS-398 significantly inhibited HGF- and IL-6-induced release of AA, PG synthesis, and proliferation in SG231 cells as well as two other human cholangiocarcinoma cell lines, HuCCT1 and CC-LP-1 cells. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 83-89 interleukin 6 Homo sapiens 123-127 32746565-8 2020 Compared with the control group, the expressions of IL-6 mRNA were increased in the 0.1 and 1.0 mg/L PFOS groups (P<0.05) , and the expressions of IL-10 mRNA were decreased in the 0.01 mg/L, 0.1 mg/L and 1.0 mg/L PFOS groups (P<0.05) . perfluorooctane sulfonic acid 101-105 interleukin 6 Homo sapiens 52-56 32674627-0 2021 Association of the IL-6 Rs1800796 SNP with Concentration/dose Ratios of Tacrolimus and Donor Liver Function after Transplantation. Tacrolimus 72-82 interleukin 6 Homo sapiens 19-23 12154423-9 2002 MEASUREMENTS AND MAIN RESULTS: In the control and tranexamic acid groups, tumor necrosis factor-alpha, IL-6, and IL-10 secretion by whole blood cell cultures were rapidly decreased, whereas IL-8 secretion was unaffected. Tranexamic Acid 50-65 interleukin 6 Homo sapiens 103-107 12067898-6 2002 Pretreatment with pertussis toxin, GF109203X, and pyrrolidine dithiocarbamate inhibited MCP-1-dependent IL-6 release, suggesting the involvement of G(i) proteins, protein kinase C, and nuclear factor-kappaB (NF-kappaB). bisindolylmaleimide I 35-44 interleukin 6 Homo sapiens 104-108 10232875-5 1999 RESULTS: When the cells were cultured with LPS, IL-6, and TNF-alpha but not IL-1beta, ATP levels increased significantly at 6 h, followed by a decrease at 24 h. Enhancement of oxygen consumption, which was completely blocked by antimycin A, was also shown at 3 h by the exposure to these substrates. Antimycin A 228-239 interleukin 6 Homo sapiens 48-52 32674627-2 2021 Here, we aimed to assess the potential influence of the IL-6 single nucleotide polymorphism (SNP) rs1800796 on the concentration/dose (C/D) ratios of tacrolimus and donor liver function in Chinese liver transplant patients. Tacrolimus 150-160 interleukin 6 Homo sapiens 56-60 12039983-6 2002 Pretreatment with pertussis toxin, GF109203X, BAPTA-AM, and pyrrolidine dithiocarbamate inhibited MCP-1-dependent IL-6 and ICAM-1 synthesis, suggesting the involvement of Gi-proteins, protein kinase C, intracellular Ca(2+), and nuclear factor-kappaB (NF-kappaB) in MCP-1 signaling. bisindolylmaleimide I 35-44 interleukin 6 Homo sapiens 114-118 10069413-0 1999 Inhibition of IL-6 and IL-8 induction from cultured rheumatoid synovial fibroblasts by treatment with aurothioglucose. Aurothioglucose 102-117 interleukin 6 Homo sapiens 14-18 32674627-5 2021 The IL-6 rs1800796 polymorphism in recipients was found to be correlated with the C/D ratios of tacrolimus at months 2 to month 6 after transplantation. Tacrolimus 96-106 interleukin 6 Homo sapiens 4-8 10069413-3 1999 In this study, we examined the effect of one of the monovalent gold compounds, aurothioglucose (AuTG), on the IL-1-induced production of IL-6, IL-8 and granulocyte macrophage colony stimulating factor (GM-CSF) from rheumatoid synovial fibroblasts (RSF) isolated from three RA patients. Aurothioglucose 79-94 interleukin 6 Homo sapiens 137-141 12039983-6 2002 Pretreatment with pertussis toxin, GF109203X, BAPTA-AM, and pyrrolidine dithiocarbamate inhibited MCP-1-dependent IL-6 and ICAM-1 synthesis, suggesting the involvement of Gi-proteins, protein kinase C, intracellular Ca(2+), and nuclear factor-kappaB (NF-kappaB) in MCP-1 signaling. 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 46-54 interleukin 6 Homo sapiens 114-118 10069413-4 1999 IL-6 and IL-8 induction but not GM-CSF induction was inhibited in most of the RSF after pretreatment with AuTG. Aurothioglucose 106-110 interleukin 6 Homo sapiens 0-4 12009364-10 2002 1alpha,25(OH)(2)-vitamin D(3), with or without 17beta-E(2), decreased interleukin-6 levels to 27% and 38% of control group, respectively. 17beta-e 47-55 interleukin 6 Homo sapiens 70-83 32674627-7 2021 In conclusion, the IL-6 rs1800796 polymorphism was associated with the C/D ratios of tacrolimus and post-transplant donor liver function. Tacrolimus 85-95 interleukin 6 Homo sapiens 19-23 32610428-9 2020 IL-6 and lymphocytes count are possible biomarkers, useful for identifying frail patients and predicting the progression of frailty in PCa under ADT. adt 145-148 interleukin 6 Homo sapiens 0-4 10815616-0 1999 Serum levels of IL-6 type cytokines and soluble IL-6 receptors in active B-cell chronic lymphocytic leukemia and in cladribine induced remission. Cladribine 116-126 interleukin 6 Homo sapiens 16-20 10815616-0 1999 Serum levels of IL-6 type cytokines and soluble IL-6 receptors in active B-cell chronic lymphocytic leukemia and in cladribine induced remission. Cladribine 116-126 interleukin 6 Homo sapiens 48-52 11961080-9 2002 Pretreatment of human monocytes with D-43787 inhibited lipopolysaccharide-induced proinflammatory cytokines IL-6 and TNFalpha with an IC(50) of 1.2 +/- 0.1 and 4.7 +/- 0.9 microM, respectively. N-(N-((1-tert-butyloxycarbonyl)indolin-2-carbonyl)indolin-2-carbonyl)-(N-epsilon-benzyloxycarbonyl)-2-lysine methyl ester 37-44 interleukin 6 Homo sapiens 108-112 11918718-10 2002 EPA treatment results also in lipid peroxidation and in decreased PGE2 and IL-6 secretion after UVB-irradiation. Eicosapentaenoic Acid 0-3 interleukin 6 Homo sapiens 75-79 9882597-3 1999 BEAS-2B cells, exposed to residual oil fly ash particles (ROFA), responded with an immediate (<30 s) increase in intracellular calcium levels ([Ca2+]i), increases of key inflammatory cytokine transcripts (i.e., IL-6, IL-8, TNFalpha) within 2 h exposure, and subsequent release of IL-6 and IL-8 cytokine protein after 4 h exposure. Oils 35-38 interleukin 6 Homo sapiens 214-218 9882597-3 1999 BEAS-2B cells, exposed to residual oil fly ash particles (ROFA), responded with an immediate (<30 s) increase in intracellular calcium levels ([Ca2+]i), increases of key inflammatory cytokine transcripts (i.e., IL-6, IL-8, TNFalpha) within 2 h exposure, and subsequent release of IL-6 and IL-8 cytokine protein after 4 h exposure. Oils 35-38 interleukin 6 Homo sapiens 283-287 32536965-14 2020 Second, the molecular docking results showed that there was a certain affinity between the core compounds (kaempferol, quercetin, 7-Methoxy-2-methyl isoflavone, naringenin, formononetin) and core target genes (IL6, IL1B, CCL2). kaempferol 107-117 interleukin 6 Homo sapiens 210-213 9886724-8 1998 In patients with chronic heart failure, serum uric acid concentrations correlated with circulating levels of sTNFR1 (r=0.74), interleukin-6 (r=0.66), sTNFR2 (r=0.63), TNFa (r=0.60) (all P<0.001), and ICAM-1 (r=0.41, P<0.01). Uric Acid 46-55 interleukin 6 Homo sapiens 126-139 31978425-6 2020 Additionally, our findings demonstrate that nobiletin potently ameliorated IL-21-induced increased production of reactive oxygen species and 4-hydroxynonenal, increased expression of interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and high-mobility group box 1 (HMGB1), and decreased mitochondrial membrane potential. nobiletin 44-53 interleukin 6 Homo sapiens 183-196 9886724-9 1998 In stepwise regression analyses, serum uric acid emerged as the strongest predictor of ICAM-1, interleukin-6, TNF, sTNFR1 and sTNFR2, independent of diuretic dose, age, body mass index, alcohol intake, serum creatinine, plasma insulin and glucose, and insulin sensitivity. Uric Acid 39-48 interleukin 6 Homo sapiens 95-108 11771709-0 2002 Effects of polyethylene and alpha-alumina particles on IL-6 expression and secretion in primary cultures of human osteoblastic cells. alpha-alumina 28-41 interleukin 6 Homo sapiens 55-59 11771709-1 2002 The effect of two biomaterials, polyethylene and alpha-alumina, on interleukin-6 (IL-6) secretion and expression has been studied in human osteoblasts in primary culture. Polyethylene 32-44 interleukin 6 Homo sapiens 67-80 11771709-1 2002 The effect of two biomaterials, polyethylene and alpha-alumina, on interleukin-6 (IL-6) secretion and expression has been studied in human osteoblasts in primary culture. alpha-alumina 49-62 interleukin 6 Homo sapiens 67-80 11771709-1 2002 The effect of two biomaterials, polyethylene and alpha-alumina, on interleukin-6 (IL-6) secretion and expression has been studied in human osteoblasts in primary culture. alpha-alumina 49-62 interleukin 6 Homo sapiens 82-86 11771709-8 2002 The maximum IL-6 secretion elicited by alpha-alumina was produced at 10 mg particles well while maximum response with polyethylene required 50 mg well. alpha-alumina 39-52 interleukin 6 Homo sapiens 12-16 11771709-11 2002 In conclusion and in our experimental conditions, polyethylene as well as alpha-alumina increased both the expression and the secretion of IL-6 in human osteoblastic cells in primary culture and stimulation from polyethylene appears stronger than that from alpha-alumina at the same dose. Polyethylene 50-62 interleukin 6 Homo sapiens 139-143 11771709-11 2002 In conclusion and in our experimental conditions, polyethylene as well as alpha-alumina increased both the expression and the secretion of IL-6 in human osteoblastic cells in primary culture and stimulation from polyethylene appears stronger than that from alpha-alumina at the same dose. alpha-alumina 74-87 interleukin 6 Homo sapiens 139-143 9781636-6 1998 Plasma TSH levels were 27% lower 240 minutes after IL-6 relative to control levels (0.93 +/- 0.10 v 1.28 +/- 0.18 mIU/mL, P = .001), but recovered by 24 hours. Thyrotropin 7-10 interleukin 6 Homo sapiens 51-55 9781636-14 1998 Alternatively, IL-6 may have suppressed TSH secretion via a direct suprapituitary action. Thyrotropin 40-43 interleukin 6 Homo sapiens 15-19 31978425-6 2020 Additionally, our findings demonstrate that nobiletin potently ameliorated IL-21-induced increased production of reactive oxygen species and 4-hydroxynonenal, increased expression of interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and high-mobility group box 1 (HMGB1), and decreased mitochondrial membrane potential. nobiletin 44-53 interleukin 6 Homo sapiens 198-202 11771709-11 2002 In conclusion and in our experimental conditions, polyethylene as well as alpha-alumina increased both the expression and the secretion of IL-6 in human osteoblastic cells in primary culture and stimulation from polyethylene appears stronger than that from alpha-alumina at the same dose. Polyethylene 212-224 interleukin 6 Homo sapiens 139-143 11771709-11 2002 In conclusion and in our experimental conditions, polyethylene as well as alpha-alumina increased both the expression and the secretion of IL-6 in human osteoblastic cells in primary culture and stimulation from polyethylene appears stronger than that from alpha-alumina at the same dose. alpha-alumina 257-270 interleukin 6 Homo sapiens 139-143 31943712-5 2020 The results showed that nickel could induce cell apoptosis, increase oxidative stress, and promote the expression of pro-inflammatory cytokines, including tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, IL-8, C-reaction protein. Nickel 24-30 interleukin 6 Homo sapiens 208-212 9725254-3 1998 Studies of cytokine production over 6 to 24 h demonstrated that IL-6 and GM-CSF release from both cell types were inhibited by brefeldin A (BFA) following activation with calcium ionophore, A23187. Brefeldin A 127-138 interleukin 6 Homo sapiens 64-68 9725254-3 1998 Studies of cytokine production over 6 to 24 h demonstrated that IL-6 and GM-CSF release from both cell types were inhibited by brefeldin A (BFA) following activation with calcium ionophore, A23187. Brefeldin A 140-143 interleukin 6 Homo sapiens 64-68 9725254-3 1998 Studies of cytokine production over 6 to 24 h demonstrated that IL-6 and GM-CSF release from both cell types were inhibited by brefeldin A (BFA) following activation with calcium ionophore, A23187. Calcimycin 190-196 interleukin 6 Homo sapiens 64-68 11805217-6 2002 Furthermore, inhibition of PDE3 (amrinone) abolished the effect of LPS on IL-6, but attenuated TNF-alpha production. Amrinone 33-41 interleukin 6 Homo sapiens 74-78 32174113-6 2020 Another key finding of our study is that donepezil could reduce the expression of tumor necrosis factor receptor-alpha (TNF-alpha) and interleukin-6 (IL-6) by more than half at both the mRNA and protein transcriptional levels. Donepezil 41-50 interleukin 6 Homo sapiens 135-148 11739453-8 2001 Plasma IL-6 levels at 3 h were increased by clenbuterol (P = 0.02) and CL316243 (P = 0.02) but not dobutamine (P = 0.51), compared with placebo. Clenbuterol 44-55 interleukin 6 Homo sapiens 7-11 9725254-4 1998 Monensin had similar inhibitory effects to that of BFA on the initial and ongoing IL-6 release from KU812 cells. Brefeldin A 51-54 interleukin 6 Homo sapiens 82-86 9725254-7 1998 BFA significantly inhibited both the constitutive secretion of IL-6 and the immediate ionophore-induced increase in IL-6 release from KU812 cells at 20 min postactivation. Brefeldin A 0-3 interleukin 6 Homo sapiens 63-67 9725254-7 1998 BFA significantly inhibited both the constitutive secretion of IL-6 and the immediate ionophore-induced increase in IL-6 release from KU812 cells at 20 min postactivation. Brefeldin A 0-3 interleukin 6 Homo sapiens 116-120 9648083-9 1998 The concentration of IL-6 in the supernatant of stimulated monocytes was highest with Glu/Bic (1023 +/- 278 pg/ml) and Amino/Bic (776 +/- 296 pg/ml) an lowest with Glu/lac pH 5.5 (46 +/- 22 pg/ml) and Glu-poly/PBS (32 +/- 13 pg/ml). amino 119-124 interleukin 6 Homo sapiens 21-25 9581864-2 1998 In the present study, we investigated the effect of tiludronate, a bisphosphonate known to inhibit bone resorption, on the PGF2alpha- and PGE1-induced IL-6 synthesis in these cells. Dinoprost 123-132 interleukin 6 Homo sapiens 151-155 9581864-10 1998 These results strongly suggest that tiludronate inhibits PGF2alpha-induced IL-6 synthesis via suppression of phosphatidylcholine-hydrolyzing phospholipase D activation in osteoblasts, and that the inhibitory effect is exerted at the point between heterotrimeric GTP-binding protein and phospholipase D. Dinoprost 57-66 interleukin 6 Homo sapiens 75-79 11850221-2 2001 In this study, a 16 amino acid peptide, AROHIB, has been used in an attempt to block the ability of IL-6 plus IL-6sR to stimulate aromatase activity in stromal fibroblasts. amino acid peptide 20-38 interleukin 6 Homo sapiens 100-104 32174113-6 2020 Another key finding of our study is that donepezil could reduce the expression of tumor necrosis factor receptor-alpha (TNF-alpha) and interleukin-6 (IL-6) by more than half at both the mRNA and protein transcriptional levels. Donepezil 41-50 interleukin 6 Homo sapiens 150-154 11792009-6 2001 When cultured in the absence of estrogen, human mast cells treated with PMA or A23187 demonstrated significantly greater release of TNF-alpha and IL-6 than cells grown under estrogen-depleted condition. Calcimycin 79-85 interleukin 6 Homo sapiens 146-150 32062076-6 2020 Besides, Cap attenuated APAP-induced overproduction and release of proinflammatory mediators like TNF-alpha, IL-1beta, IL-17A, IL-6, and MCP-1. Acetaminophen 24-28 interleukin 6 Homo sapiens 127-131 11792009-7 2001 Our results show that treatment of mast cells with estrogen prevented PMA or A23187-stimulated TNF-alpha or IL-6 release. Calcimycin 77-83 interleukin 6 Homo sapiens 108-112 11820460-1 2001 We analyzed the influence of heparins (unfractionated heparin, UFH and low molecular weight heparin certoparin) on the generation of IL-1ra, IL-6, IL-10, and IL-12p40 and from leukocyte fractions in vitro. certoparin 100-110 interleukin 6 Homo sapiens 141-145 32347005-6 2020 RESULTS: The CRP and IL-6 levels were lower in the TXA + DEX group than in the TXA group (all P < 0.001) at 24 h, 48 h, and 72 h postoperatively. Tranexamic Acid 51-54 interleukin 6 Homo sapiens 21-25 11820460-4 2001 Certoparin but not UFH led to a dose-dependent increase in IL-6 from non-stimulated PBMC. certoparin 0-10 interleukin 6 Homo sapiens 59-63 11497296-5 2001 RESULTS: Phenytoin and carbamazepine, which inactivate voltage-gated sodium channels, inhibited the secretion of PSA by LNCaP and IL-6 by DU-145 and PC-3 cell lines. Phenytoin 9-18 interleukin 6 Homo sapiens 130-134 32256360-9 2020 The in vitro anti-inflammatory activity was carried out on monosodium urate (MSU) crystal-induced pro-inflammatory cytokines (i.e., interleukin (IL)1alpha, IL-1beta, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha) secretion using human peripheral blood mononuclear cells and ELISA technique, and prostaglandin E2 (PGE2)secretion using radioimmunoassay. Uric Acid 59-75 interleukin 6 Homo sapiens 166-170 11380138-4 2001 We have used the agarose system to demonstrate the differential effects of oxidised and non-oxidised PE particles on the release of proinflammatory products such as interleukin-1beta (IL-1beta), IL-6, and tumour necrosis factor-alpha (TNF-alpha) from monocytes/macrophages (M/M). Polyethylene 101-103 interleukin 6 Homo sapiens 195-199 32256360-9 2020 The in vitro anti-inflammatory activity was carried out on monosodium urate (MSU) crystal-induced pro-inflammatory cytokines (i.e., interleukin (IL)1alpha, IL-1beta, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha) secretion using human peripheral blood mononuclear cells and ELISA technique, and prostaglandin E2 (PGE2)secretion using radioimmunoassay. Uric Acid 77-80 interleukin 6 Homo sapiens 166-170 32142484-13 2020 DISCUSSION: Sequential administration of parecoxib and celecoxib in patients with predicted SAP obtained about half-reduction of SAP occurrence through decreasing serum levels of TNF-alpha and IL-6. parecoxib 41-50 interleukin 6 Homo sapiens 193-197 11281303-10 2001 CONCLUSIONS: Short-term therapy with simvastatin decreases the plasma concentrations of markers of peroxidation of lipids and of stable metabolites of nitric oxide in hypercholesterolaemic patients, but leaves levels of interleukin 6 unaffected. Simvastatin 37-48 interleukin 6 Homo sapiens 220-233 32147078-1 2020 OBJECTIVES: The present study was aimed to investigate the effect of alpha-tocopherol supplementation on biomarkers of endothelial function (Intercellular Adhesion Molecule 1 and Vascular Cell Adhesion Protein 1) and inflammatory markers (Interleukin 6 and high-sensitivity C-reactive protein) among the hemodialysis patients. alpha-Tocopherol 69-85 interleukin 6 Homo sapiens 239-252 11289656-9 2001 NS-398 exhibited an inhibition of IL-1beta-induced IL-6 production as well as PGE2 production. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 0-6 interleukin 6 Homo sapiens 51-55 11007619-6 2000 Ciprofloxacin inhibited production of TNF-alpha, IL-6, IL-1, and PGE(2) in human monocytes exposed to titanium particles. Ciprofloxacin 0-13 interleukin 6 Homo sapiens 49-53 31899823-16 2020 Patients with a detectable PSA after ADT had elevated levels of IL-6 (P = .049) and IL-8 (P = .013) at PSA progression as compared with those with an undetectable PSA. adt 37-40 interleukin 6 Homo sapiens 64-68 11215744-4 2000 Correlation analyses for TGF-beta and IL-6 indicated a strong dependence of the production of hyaluronan on cytokine levels and, to a lesser extent, on IL-1beta levels. Hyaluronic Acid 94-104 interleukin 6 Homo sapiens 38-42 31843963-7 2020 Moreover, IpaJ was efficient in the prevention of NF-kappaB translocation to the nucleus and ultimately interfered with the secretion of the proinflammatory cytokines IL-1beta, IL-6, and IL-8 in infected HeLa cells. ipaj 10-14 interleukin 6 Homo sapiens 177-181 30972761-9 2020 RESULTS: Significant increase of serum IL-6 associated with a significant decrease in serum 25(OH)-vitamin D was observed in the LM-infants compared to the C-infants (P < .001 for both). 25(oh)-vitamin d 92-108 interleukin 6 Homo sapiens 39-43 11053781-0 2000 Alpha tocopherol supplementation decreases serum C-reactive protein and monocyte interleukin-6 levels in normal volunteers and type 2 diabetic patients. alpha-Tocopherol 0-16 interleukin 6 Homo sapiens 81-94 30972761-11 2020 CONCLUSIONS: Deficiency of 25(OH)-vitamin D in LM-infants may result in dysregulation of the immune responses with elevation of a proinflammatory cytokine (IL-6). 25(oh)-vitamin d 27-43 interleukin 6 Homo sapiens 156-160 10924340-4 2000 In parallel, IL-6 decreases both rifampicin- and phenobarbital-mediated induction of CYP2B6, CYP2C8, CYP2C9, and CYP3A4. Phenobarbital 49-62 interleukin 6 Homo sapiens 13-17 31706101-9 2020 We found that DHP inhibited IL-1beta-induced upregulation of ROS, TNF-alpha, IL-6, MMP-3, ADAMTS-5. 1,4-dihydropyridine 14-17 interleukin 6 Homo sapiens 77-81 31781916-8 2020 Activation of SIRT1 via SRT1720 in combination with NVP-BEZ235 significantly decreased breast cancer cells viability in IL-6 pretreatment cultures. dactolisib 52-62 interleukin 6 Homo sapiens 120-124 10894816-0 2000 Interleukin-6 stimulates LDL receptor gene expression via activation of sterol-responsive and Sp1 binding elements. Sterols 72-78 interleukin 6 Homo sapiens 0-13 10894816-8 2000 Studies using a reporter plasmid with a functionally disrupted sterol-responsive element (SRE)-1 revealed a reduced stimulatory response to IL-6. Sterols 63-69 interleukin 6 Homo sapiens 140-144 10894816-9 2000 In gel-shift assays, nuclear extracts of IL-6-treated HepG2 cells showed an induced binding of SRE binding protein (SREBP)-1a and SRE binding protein(SREBP)-2 to the SRE-1 that was independent of the cellular sterol content and an induced binding of Sp1 and Sp3 to repeat 3 of the LDL-R promoter. Sterols 209-215 interleukin 6 Homo sapiens 41-45 24383530-10 2000 The addition of latex and polyethylene particles to human M/M resulted in a dose-dependent increase in IL-1beta, IL-6, and TNF-alpha release. Polyethylene 26-38 interleukin 6 Homo sapiens 113-117 32454491-7 2020 Furthermore, YiQi GuBen formula suppressed PDGF-BB-induced expression of phosphorylated p65 and the release of inflammatory factors TNF-alpha, IL-1beta, IL-6, and IL-8 in ASMCs. yiqi guben 13-23 interleukin 6 Homo sapiens 153-157 10708165-11 2000 The peak concentration of IL-6 was significantly correlated with the admission bilirubin and the intraoperative blood product requirement. Bilirubin 79-88 interleukin 6 Homo sapiens 26-30 31729529-0 2019 Cajanonic acid A regulates the ratio of Th17/Treg via inhibition of expression of IL-6 and TGF-beta in insulin-resistant HepG2 cells. Amino Acids 0-16 interleukin 6 Homo sapiens 82-86 10708165-12 2000 A multivariate regression model revealed that the serum bilirubin and the intraoperative blood product requirement were the independent factors that influenced the peak concentration of IL-1beta or IL-6. Bilirubin 56-65 interleukin 6 Homo sapiens 198-202 31729530-2 2019 Moracin treatment significantly inhibited the LPS-induced inflammatory cytokine accumulation (IL-1beta, IL-6 and TNF-alpha) in nucleus pulposus cells. moracin C 0-7 interleukin 6 Homo sapiens 104-108 31759770-10 2019 LPS-stimulated production of IL-6 correlated negatively with the parenteral dose of eicosapentaenoic acid + docosahexaenoic acid. Eicosapentaenoic Acid 84-105 interleukin 6 Homo sapiens 29-33 10685834-0 2000 Interleukin 6 reduces serum urate concentrations. Uric Acid 28-33 interleukin 6 Homo sapiens 0-13 31824305-15 2019 2-HEC, 2-HPC, and GCBD dose-dependently inhibited LPS-induced IL-1beta, TNF-alpha, and IL-6 synthesis. glycol monoacetate 0-5 interleukin 6 Homo sapiens 87-91 10564725-10 2000 Cytochalasin B, an actin-disrupting agent, severely affected the LPS induced increased percentage of "S" phase cells and IL-6 synthesis in HSILPF. Cytochalasin B 0-14 interleukin 6 Homo sapiens 121-125 10599049-9 1999 At the highest concentrations tested, IL-6 production values were 58 +/- 9% and 53 +/- 8% of those at base line for MG63 and SaOs cells, respectively. mg63 116-120 interleukin 6 Homo sapiens 38-42 31933795-3 2019 The proliferation of thyroid cancer stem cells after IL-6 treatment was assessed by the MTT method. thiazolyl blue 88-91 interleukin 6 Homo sapiens 53-57 19003130-6 1999 Furthermore, we found that hIL-6 production level of I13 was slightly improved by raising the CO(2) concentration from 5 to 8% possibly because of the enhanced growth rate. co(2) 94-99 interleukin 6 Homo sapiens 27-32 31777581-19 2019 Pretreatment with the STAT3 inhibitor, S3I-201, decreased sphere size, and downregulated NANOG, SOX2, and OCT3/4 protein levels, compared with IL-6 treatment alone. 8,2'-S-cycloinosinyl-(3',5')-8,2'-S-cycloadenosine 39-42 interleukin 6 Homo sapiens 143-147 19003130-9 1999 However when cultured in 8% CO(2) condition, not only cell number, but also productivity increased significantly, resulted in great augmentation of hIL-6 production, maximum production being 88.6 mug/ml/3 days. co(2) 28-33 interleukin 6 Homo sapiens 148-153 10457265-0 1999 The anti-androgen hydroxyflutamide and androgens inhibit interleukin-6 production by an androgen-responsive human osteoblastic cell line. hydroxyflutamide 18-34 interleukin 6 Homo sapiens 57-70 10457265-5 1999 Of note, the specific AR antagonist, hydroxyflutamide, also inhibited IL-6 mRNA levels by 70%. hydroxyflutamide 37-53 interleukin 6 Homo sapiens 70-74 10457265-6 1999 Consistent with the Northern analyses, treatment with 5alpha-DHT, testosterone, and hydroxyflutamide also inhibited IL-6 protein production by 79%, 62%, and 71%, respectively (p < 0.001), while these agents had no effect on IL-6 soluble receptor levels. hydroxyflutamide 84-100 interleukin 6 Homo sapiens 116-120 9589658-2 1998 In this context, the present study aimed to specify the contributions of IL-6 to the regulation of pituitary-adrenal secretory activity and GH and TSH secretion, as well as to the regulation of central nervous sleep and mood in healthy men. Thyrotropin 147-150 interleukin 6 Homo sapiens 73-77 10457265-6 1999 Consistent with the Northern analyses, treatment with 5alpha-DHT, testosterone, and hydroxyflutamide also inhibited IL-6 protein production by 79%, 62%, and 71%, respectively (p < 0.001), while these agents had no effect on IL-6 soluble receptor levels. hydroxyflutamide 84-100 interleukin 6 Homo sapiens 227-231 9666567-5 1998 IL-2, IL-3, IL-6, and INF-alpha are able to directly stimulate glucocorticoid production by zona fasciculata and zona reticularis cells, whereas IL-1 exerts an analogous effect through an indirect mechanism involving the stimulation of catecholamine release by chromaffin cells and/or the activation of the intramedullary CRH/ACTH system; again, TNF-alpha depresses glucocorticoid synthesis. chromaffin 261-271 interleukin 6 Homo sapiens 12-16 10457265-7 1999 Finally, we demonstrated that hydroxyflutamide treatment of hFOB/AR-6 cells markedly inhibited the activation and binding of NF-kappaB (a known stimulator of IL-6 gene transcription) to its response element, thus providing a potential mechanism for its effect on IL-6 production by osteoblasts. hydroxyflutamide 30-46 interleukin 6 Homo sapiens 158-162 31572532-8 2019 The results indicated that lipopolysaccharide (LPS) significantly increased the pro-inflammatory cytokines TNF-alpha, IL-1beta and IL-6 in CCD-18Co cells, which was markedly ameliorated by ASI. astragaloside A 189-192 interleukin 6 Homo sapiens 131-135 10457265-7 1999 Finally, we demonstrated that hydroxyflutamide treatment of hFOB/AR-6 cells markedly inhibited the activation and binding of NF-kappaB (a known stimulator of IL-6 gene transcription) to its response element, thus providing a potential mechanism for its effect on IL-6 production by osteoblasts. hydroxyflutamide 30-46 interleukin 6 Homo sapiens 263-267 10457265-9 1999 Moreover, our findings also indicate that hydroxyflutamide, which is a known AR antagonist in most tissues, may function as a selective AR modulator for effects on IL-6 production by osteoblasts. hydroxyflutamide 42-58 interleukin 6 Homo sapiens 164-168 31626100-6 2019 Besides analgesic, lidocaine has systemic anti-inflammatory and neuroprotective effect.Primary aim of this trial is to determine the influence of local anesthesia with lidocaine on the perioperative levels of pro-inflammatory cytokines interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in plasma and CSF in cerebral aneurysm patients. Lidocaine 19-28 interleukin 6 Homo sapiens 255-301 10449154-3 1999 We report that the endogenous CS hydrocortisone and the synthetic CS clobetasol-17-propionate strongly inhibited the production of the inflammatory mediators interleukin (IL)-12 p70, tumor necrosis factor alpha (TNF-alpha), and IL-6 by lipopolysaccharide (LPS)-stimulated monocyte-derived immature DC (iDC) in vitro. Clobetasol 69-93 interleukin 6 Homo sapiens 228-232 9486955-8 1997 In two other acute exposures, the peak increases in TNF-alpha, IL-6 and total cell numbers were observed at 48 h post exposure time, whereas the peak increase in dendritic cells occurred at 24 h. After subacute exposure to 48 h TDI, where TDI concentrations were relatively low (0.006 or 0.110 ppm), a parallel increase in TNF-alpha and IL-6 levels, dendritic and total cell numbers were observed at 0 h post exposure time. Toluene 2,4-Diisocyanate 228-231 interleukin 6 Homo sapiens 63-67 9267955-0 1997 Effect of ciprofloxacin on the accumulation of interleukin-6, interleukin-8, and nitrite from a human endothelial cell model of sepsis. Ciprofloxacin 10-23 interleukin 6 Homo sapiens 47-60 9267955-1 1997 OBJECTIVE: To determine the effect of the quinolone antibiotic ciprofloxacin, on interleukin-6, interleukin-8, and nitrite production by human endothelial cells. Ciprofloxacin 63-76 interleukin 6 Homo sapiens 81-94 31626100-6 2019 Besides analgesic, lidocaine has systemic anti-inflammatory and neuroprotective effect.Primary aim of this trial is to determine the influence of local anesthesia with lidocaine on the perioperative levels of pro-inflammatory cytokines interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in plasma and CSF in cerebral aneurysm patients. Lidocaine 168-177 interleukin 6 Homo sapiens 255-301 9267955-7 1997 Ciprofloxacin decreased interleukin-6 accumulation (p = .001). Ciprofloxacin 0-13 interleukin 6 Homo sapiens 24-37 9267955-10 1997 CONCLUSIONS: Ciprofloxacin differentially modulates interleukin-6 and interleukin-8 expression. Ciprofloxacin 13-26 interleukin 6 Homo sapiens 52-65 9263986-10 1997 Phospho-L-serine as an antagonist of the phosphatidylserine (PS) mediated recognition pathway for apoptotic cell disposal was able to reduce binding and IL-6 production by HMC but not phagocytosis. plasmenylserine 0-16 interleukin 6 Homo sapiens 153-157 10362713-0 1999 Reactive oxygen intermediates stimulate interleukin-6 production in human bronchial epithelial cells. reactive oxygen 0-15 interleukin 6 Homo sapiens 40-53 31397158-5 2019 Interleukin (IL)-6 was associated with Oxy-PAHs of 1,8-naphthalic anhydride, xanthone, and benzo[h]quinolone, especially, whereas IL-1beta and tumor necrosis factor (TNF)-alpha were associated with most species. benzo[h]quinolone 91-108 interleukin 6 Homo sapiens 0-18 10022397-8 1999 Thyroid carcinoma patients on TSH suppressive therapy also had significantly raised levels of IL-6 (2.5 +/- 0.42 ng/L) and IL-8 (4.4 +/- 0.63 ng/L). Thyrotropin 30-33 interleukin 6 Homo sapiens 94-98 9036929-0 1997 L-ascorbic acid inhibits UVA-induced lipid peroxidation and secretion of IL-1alpha and IL-6 in cultured human keratinocytes in vitro. Ascorbic Acid 0-15 interleukin 6 Homo sapiens 87-91 31243136-7 2019 Altogether, these data identify a new miR-455-5p/SOCS3/STAT3 signaling pathway that contributes to viral replication and IL-6 production in RABV-infected cells, with PGG exerting its antiviral effect by inhibiting the production of miR-455-5p and the activation of STAT3.IMPORTANCE Rabies virus causes lethal encephalitis in mammals and poses a serious public health threat in many parts of the world. pentagalloylglucose 166-169 interleukin 6 Homo sapiens 121-125 11089884-5 1999 Competitive RT-PCR and Ala-pNA activity assays revealed that IL-6 and sIL-6R significantly increased the mRNA expression and activity of APN in both osteosarcoma cell lines. ala-pna 23-30 interleukin 6 Homo sapiens 61-65 31243136-13 2019 Furthermore, the downregulated STAT3 inhibits the production of IL-6, thereby contributing to a reduction in the inflammatory response in vivo Our study indicates that PGG effectively inhibits the replication of RABV by the miR-455-5p/SOCS3/STAT3/IL-6-dependent pathway. pentagalloylglucose 168-171 interleukin 6 Homo sapiens 64-68 9788508-4 1998 NiCl2 and CoCl2 upregulate, especially in concentrations of 1 mM, the expression of adhesion molecules (e.g., E-selectin and intercellular adhesion molecule-1), as well as the cytokines IL-6 and IL-8, as shown by enzyme immunoassay and Northern blot analysis. cobaltous chloride 10-15 interleukin 6 Homo sapiens 186-190 9058654-4 1997 RESULTS: Compared with PBS, sera from controls and 24 patients with SLE suppressed IL-6 release from IL-1beta pretreated cells. pbs 23-26 interleukin 6 Homo sapiens 83-87 31243136-13 2019 Furthermore, the downregulated STAT3 inhibits the production of IL-6, thereby contributing to a reduction in the inflammatory response in vivo Our study indicates that PGG effectively inhibits the replication of RABV by the miR-455-5p/SOCS3/STAT3/IL-6-dependent pathway. pentagalloylglucose 168-171 interleukin 6 Homo sapiens 247-251 9547608-0 1997 Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human endothelial cell production of interleukin-6. docosahexaenoic 0-15 interleukin 6 Homo sapiens 97-110 31496653-10 2019 After 1 year of treatment with acarbose or metformin, IL-6, TNF-alpha, IL-1beta and ferritin levels were significantly decreased compared with the baseline. Acarbose 31-39 interleukin 6 Homo sapiens 54-58 9547608-0 1997 Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human endothelial cell production of interleukin-6. Eicosapentaenoic Acid 20-42 interleukin 6 Homo sapiens 97-110 9688087-13 1998 Supplementation of TPN with glutamine dipeptides could reverse TPN-induced suppression of IL-6 release and improved mucosal structure, which may be beneficial in various disease conditions in which TPN is an integrated part of patients management. glutamine dipeptides 28-48 interleukin 6 Homo sapiens 90-94 31441836-9 2019 CONCLUSION: The combined administration of TXA + Dexa significantly reduced the level of postoperative CRP and IL-6, relieve postoperative pain, ameliorate the incidence of POVN, provide additional analgesic and antiemetic effects, reduce postoperative fatigue, and improve ROM, without increasing the risk of complications in primary TKA. Tranexamic Acid 43-46 interleukin 6 Homo sapiens 111-115 9776820-4 1998 In addition, the results consistently demonstrated that at a yeast cell to PBMNC ratio of 20:1, formalin-preserved Malassezia, irrespective of serovar, growth phase or PBMNC donor, were capable of significantly (P<0.05) decreasing the release of both immunochemical IL-6 and IL-1beta plus bioactive IL-1beta and TNF-alpha below that of unstimulated culture medium control values. Formaldehyde 96-104 interleukin 6 Homo sapiens 269-273 9076951-5 1997 Co-culture with 0.25% Iodosorb, Iodosorb conditioned medium or 20 micrograms/ml iodine enhanced TNF alpha secretion (48 +/- 3% cytotoxicity in L929 bioassay to 78 +/- 2% cytotoxicity, +/-SD) by U937 cells stimulated with sub-optimal concentrations of LPS (0.25 ng/ml) and inhibited secretion of IL-6 from cells stimulated with 10 ng/ml LPS (> 750 pg/ml to 267 +/- 52 pg/ml, +/-SD, n = 4). Iodine 80-86 interleukin 6 Homo sapiens 295-299 31534339-11 2019 The partial correlational analysis further showed that IL-6 levels were notably negative related to the HDL levels in male schizophrenia patients after age, years of education, body mass index (BMI), age of onset, total disease course, and equal dose of olanzapine were controlled (male: P=0.009; female: P=0.450). Olanzapine 254-264 interleukin 6 Homo sapiens 55-59 9403362-5 1997 3-Morpholinosydnonimine hydrochloride has been shown to significantly increase IL6 production and tartrate resistant acid phosphatase activity in FLG 29.1 cells, indicating a positive modulation of osteoclast differentiation. linsidomine 0-37 interleukin 6 Homo sapiens 79-82 9066526-3 1997 Exposure of macrophages in co-culture with osteoblasts to polyethylene particles increased the release of prostaglandin E2 and also led to the release of interleukin-6. Polyethylene 58-70 interleukin 6 Homo sapiens 154-167 9466577-5 1998 The objective of this study was to determine whether TNF-alpha activates the sphingomyelin pathway in human synovial fibroblasts (HSF) and the potential role of ceramide in HSF proliferation and apoptosis. Sphingomyelins 77-90 interleukin 6 Homo sapiens 130-133 9675546-7 1998 KE-298 significantly suppressed TNF-alpha-induced production of promatrix metalloproteinase-1 and IL-6, in a dose-dependent manner, but not that of tissue inhibitor-1 of metalloproteinases. esonarimod 0-6 interleukin 6 Homo sapiens 74-102 31055607-10 2019 AST2017-01 and chrysophanol decreased levels of interleukin (IL)-13, IL-6, and tumor necrosis factor-alpha. chrysophanic acid 15-27 interleukin 6 Homo sapiens 69-106 9675546-8 1998 The potential of KE-298 to suppress the production of matrix metalloproteinase-1 and IL-6 may explain its efficacy on rheumatoid arthritis. esonarimod 17-23 interleukin 6 Homo sapiens 85-89 9564633-10 1998 Treatment of cultured PBMC with various concentrations induced an increased synthesis of IL-1 beta (ANOVA F = 9.703, p = 0.0007), IL-6 (ANOVA F = 20.648, p = 0.0001) and a reduced production of TNF (ANOVA F = 3.770, p = 0.040). PBMC 22-26 interleukin 6 Homo sapiens 130-134 8951539-7 1996 No TGF-alpha was detectable for CAS, and 3.7-fold, and 25-fold higher levels of interleukin-6 were found for CES (257 +/- 12.7 U/10 cm2) compared with HD/HK and CAS, respectively. ARAMITE 109-112 interleukin 6 Homo sapiens 80-93 31115540-5 2019 Increased levels of proinflammatory cytokines TNF-alpha, COX-2, IL-6 and IL-1beta following UVB exposure were suppressed by the introduction of DCEQA. dceqa 144-149 interleukin 6 Homo sapiens 64-68 8894442-6 1996 Thus, in the presence of IL-2, IL-6, IL-3 or granulocyte-macrophage colony-stimulating factor (GM-CSF), the level of cytokines induced by murabutide was enhanced with no change in the other cytokines profile. murabutide 138-148 interleukin 6 Homo sapiens 31-35 8663271-4 1996 A23187 does not suppress, and it actually prolongs, the DNA-binding activity of the human heat shock transcription factor (HSF), while it alters HSF1 phosphorylation in heat shock-treated cells. Calcimycin 0-6 interleukin 6 Homo sapiens 90-121 8663271-4 1996 A23187 does not suppress, and it actually prolongs, the DNA-binding activity of the human heat shock transcription factor (HSF), while it alters HSF1 phosphorylation in heat shock-treated cells. Calcimycin 0-6 interleukin 6 Homo sapiens 123-126 9460084-7 1998 Addition of CSAIDs to OA-affected cartilage differentially regulates IL-6 and IL-8 production by inhibiting the spontaneous release of IL-6 but not IL-8 in ex vivo conditions. csaids 12-18 interleukin 6 Homo sapiens 69-73 9460084-7 1998 Addition of CSAIDs to OA-affected cartilage differentially regulates IL-6 and IL-8 production by inhibiting the spontaneous release of IL-6 but not IL-8 in ex vivo conditions. csaids 12-18 interleukin 6 Homo sapiens 135-139 9359864-5 1997 The combination of IL-6+IL-1beta led to increased turnover of sphingomyelin in Hep3B cells. Sphingomyelins 62-75 interleukin 6 Homo sapiens 19-23 9359864-7 1997 The ability of C2 and C6 to potentiate the effects of cytokines suggests that the sphingomyelin-ceramide pathway participates in induction of CRP and SAA by IL-6+IL-1beta under these experimental conditions, most likely by transducing the effects of IL-1beta. Sphingomyelins 82-95 interleukin 6 Homo sapiens 157-161 9373220-6 1997 Excess levels of the FK-506 analogue ascomycin reversed the antagonistic effect of rapamycin on IL-6 mediated growth suppression, suggesting that this biological action of rapamycin is mediated by a rapamycin/immunophilin complex. Tacrolimus 21-27 interleukin 6 Homo sapiens 96-100 31231184-5 2019 The IL-6 levels in astrocyte-derived exosomes were increased in sALS patients and positively associated with the rate of disease progression. sals 64-68 interleukin 6 Homo sapiens 4-8 9378738-10 1997 In contrast, the fluoroquinolone antibiotic ciprofloxacin, which is also a phosphodiesterase inhibitor, caused a dose-dependent inhibition of the synthesis of both tumor necrosis factor-alpha and interleukin-6 by titanium-stimulated monocytes, suggesting that ciprofloxacin suppresses the synthesis of interleukin-6 through a mechanism that is independent of cAMP. Fluoroquinolones 17-32 interleukin 6 Homo sapiens 196-209 9378738-10 1997 In contrast, the fluoroquinolone antibiotic ciprofloxacin, which is also a phosphodiesterase inhibitor, caused a dose-dependent inhibition of the synthesis of both tumor necrosis factor-alpha and interleukin-6 by titanium-stimulated monocytes, suggesting that ciprofloxacin suppresses the synthesis of interleukin-6 through a mechanism that is independent of cAMP. Fluoroquinolones 17-32 interleukin 6 Homo sapiens 302-315 9378738-10 1997 In contrast, the fluoroquinolone antibiotic ciprofloxacin, which is also a phosphodiesterase inhibitor, caused a dose-dependent inhibition of the synthesis of both tumor necrosis factor-alpha and interleukin-6 by titanium-stimulated monocytes, suggesting that ciprofloxacin suppresses the synthesis of interleukin-6 through a mechanism that is independent of cAMP. Ciprofloxacin 44-57 interleukin 6 Homo sapiens 196-209 8704044-8 1996 Multiple regression analysis (taking into account different variables of the immunosuppressive regimen applied) revealed the plasma concentration of interleukin-6 as an independent predictor of the urinary excretion of pyridinium cross-links (p < 0.05). pyridine 219-229 interleukin 6 Homo sapiens 149-162 8550818-5 1995 We propose that the sphingomyelin pathway is part of the signal transduction cascade leading to IL-6 gene expression in astrocytes, and that this pathway may be involved in IL-6-mediated neurodegenerative processes. Sphingomyelins 20-33 interleukin 6 Homo sapiens 96-100 7595543-3 1995 Complete to nearly complete inhibition of interleukin-1 beta-induced interleukin-6 production was observed with the flavonoids genistein and quercetin, the bisindole alkaloids staurosporine and K-252a, or the tyrphostin AG879. Tyrphostins 209-219 interleukin 6 Homo sapiens 69-82 8576941-6 1995 Amrinone at 26 mumol/l and NKH477 at 10 nmol/l also had a less marked inhibitory effect against the production of IL-6. Amrinone 0-8 interleukin 6 Homo sapiens 114-118 9364409-6 1997 Production of the part anti-inflammatory cytokine IL-6, was significantly increased by therapeutic concentrations of meloxicam, as well as by indomethacin. Meloxicam 117-126 interleukin 6 Homo sapiens 50-54 31231362-9 2019 C-SVMP was able to induce increased production of the cytokines IL-1beta and IL-6 and the chemokines CXCL8/IL-8, CCL2/MCP-1, and CXCL9/MIG in the human whole blood model. c-svmp 0-6 interleukin 6 Homo sapiens 77-81 8576944-3 1995 Here we demonstrate that the four Ca(2+)-channel blockers, Amlodipine, Felodipine, Isradipine and Manidipine, at nanomolar concentrations, activate the transcription of the genes encoding IL-6 and IL-8 in primary human VSMC and fibroblasts. Felodipine 71-81 interleukin 6 Homo sapiens 188-192 31035404-7 2019 DCH could inhibit the activated microglia N9 release of NO, TNF-alpha, and IL-6. dicyclohexylamine 0-3 interleukin 6 Homo sapiens 75-79 7474452-7 1995 Macrophages in vitro have a high capacity to synthesize QUIN following exposure to interferon-gamma, tumor necrosis factor-alpha, IL-1 beta and IL-6, compared to cells derived from other tissues. Quinolinic Acid 56-60 interleukin 6 Homo sapiens 144-148 9285073-4 1997 After purification and renaturation, the biological activity of the expressed product, designated as DM120, was measured by MTT method in an IL-6-dependent cell line 7TD1. dm120 101-106 interleukin 6 Homo sapiens 141-145 30938722-5 2019 In vitro, NOB treatment completely suppressed the overproduction of pro-inflammatory mediators, including PGE2, NO, COX-2, iNOS, TNF-alpha and IL-6 in IL-1beta-induced human OA chondrocytes. nobiletin 10-13 interleukin 6 Homo sapiens 143-147 9269644-15 1997 Il-6 release: Amino/Bic, 33.0 +/- 6.6%; Glu/Bic, 65.5 +/- 10.3%; Glu/Lac, 1.5 +/- 0.7% referred to RPMI). amino 14-19 interleukin 6 Homo sapiens 0-4 9329631-1 1997 The effect of Granulocyte-Macrophage, Colony Stimulating Factor (GM-CSF) and Interleukin-6 (IL-6) on leukotriene production by CML white blood cells induced by calcium ionophore (A23187) was investigated and the leukotrienes formed were identified and quantified using high performance liquid chromatography (HPLC). Calcimycin 179-185 interleukin 6 Homo sapiens 77-90 9329631-3 1997 Although GM-CSF or IL-6 alone did not stimulate the synthesis of 5-lipoxygenase product, preincubation of the white blood cells of CML with GM-CSF or IL-6 for 30 minutes at 37 degrees C enhanced the ionophore A23187 induced leukotrienes synthesis, thus the CML white blood cell suspension primed with GM-CSF or IL-6 produced 26.6 +/- 2.8 and 18.9 +/- 1.3 pmol LTC4/10(6) cells respectively, and 30.2 +/- 3.6 and 25.5 +/- 2.5 Pmol LTB4/10(6) cells. Calcimycin 209-215 interleukin 6 Homo sapiens 150-154 9329631-3 1997 Although GM-CSF or IL-6 alone did not stimulate the synthesis of 5-lipoxygenase product, preincubation of the white blood cells of CML with GM-CSF or IL-6 for 30 minutes at 37 degrees C enhanced the ionophore A23187 induced leukotrienes synthesis, thus the CML white blood cell suspension primed with GM-CSF or IL-6 produced 26.6 +/- 2.8 and 18.9 +/- 1.3 pmol LTC4/10(6) cells respectively, and 30.2 +/- 3.6 and 25.5 +/- 2.5 Pmol LTB4/10(6) cells. Calcimycin 209-215 interleukin 6 Homo sapiens 150-154 7645642-4 1995 RESULTS: Amniotic fluid interleukin-6 levels were (1) higher in women with spontaneous labor versus those with indicated deliveries (15.8 +/- 5.0 vs 2.2 +/- 0.2 ng/ml, p = 0.01), (2) inversely proportional to gestational age in women with spontaneous labor (< 34 weeks: 47.4 +/- 18.0 ng/ml vs > or = 34 weeks: 8.7 +/- 4.1 ng/ml, p = 0.001) but not in women with indicated deliveries (1.5 +/- 0.4 vs 2.4 +/- 0.3 ng/ml), (3) higher in women with a positive versus a negative chorioamnion (15.1 +/- 4.8 vs 3.0 +/- 0.8 ng/ml, p < 0.001) or amniotic fluid (17.4 +/- 7.7 vs 3.8 +/- 0.9 ng/ml, p < 0.001) culture, and (4) higher in women with a negative amniotic fluid but positive chorioamnion culture compared with women in whom both cultures were negative (10.0 +/- 4.4 vs 3.0 +/- 0.9 ng/ml, p = 0.002). chorioamnion 479-491 interleukin 6 Homo sapiens 24-37 7558123-9 1995 Following an incubation time of 24 hr, PBMC exposed to small RSV doses synthesized and released high amounts of IL-6 into the cell supernatant. PBMC 39-43 interleukin 6 Homo sapiens 112-116 7572320-3 1995 Because IL-6 is considered to be an important mediator of the acute phase response, we examined the changes in circulating IL-6 bioactivity in 38 patients with Paget"s disease treated with the nitrogen-containing bisphosphonate (3-dimethyl-amino-1-hydroxypropylidene)-1,1-bisphosphonate (dimethyl-APD). olpadronic acid 229-286 interleukin 6 Homo sapiens 8-12 7572320-3 1995 Because IL-6 is considered to be an important mediator of the acute phase response, we examined the changes in circulating IL-6 bioactivity in 38 patients with Paget"s disease treated with the nitrogen-containing bisphosphonate (3-dimethyl-amino-1-hydroxypropylidene)-1,1-bisphosphonate (dimethyl-APD). olpadronic acid 229-286 interleukin 6 Homo sapiens 123-127 21432455-4 1997 After EPA intake, at one hour after the load, the change rate of IL-6 decreased to that of before EPA. Eicosapentaenoic Acid 6-9 interleukin 6 Homo sapiens 65-69 21432455-4 1997 After EPA intake, at one hour after the load, the change rate of IL-6 decreased to that of before EPA. Eicosapentaenoic Acid 98-101 interleukin 6 Homo sapiens 65-69 21432455-7 1997 It is suggested that EPA activated IL-6, which was related to the increase of alpha(1)-AGP as an activator of immunity. Eicosapentaenoic Acid 21-24 interleukin 6 Homo sapiens 35-39 30288636-5 2019 Simvastatin and atorvastatin at 50 muM promoted reduction in all cytokine levels with statistical significance, except for IL-6, which had its reduction only induced by the use of simvastatin. Simvastatin 180-191 interleukin 6 Homo sapiens 123-127 9185243-4 1997 In human peripheral blood mononuclear cells stimulated in vitro with 1 microgram/mL endotoxin, GM-6001 at concentrations > 5 micrograms/mL blocked release of TNF alpha, but did not affect the release of either IL-1 beta or IL-6. N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide 95-102 interleukin 6 Homo sapiens 226-230 7545487-2 1995 FK506 which has a similar immunosuppressive mechanism to that of CsA also showed the same inhibitory effects except for decreased IL-5 and IL-6 mRNA expression. Tacrolimus 0-5 interleukin 6 Homo sapiens 139-143 30320916-8 2019 Further studies showed that interleukin 6 (IL-6) secretion increased after RKO cells were treated with vemurafenib. Vemurafenib 103-114 interleukin 6 Homo sapiens 28-41 7647524-3 1995 After adding the TMP (1 mmol) to the cultures, the IL-6 bioactivity were 2118 +/- 215 that were markedly lower than those in controls (4128 +/- 351, P < 0.01). Thymidine Monophosphate 17-20 interleukin 6 Homo sapiens 51-55 7647524-4 1995 It revealed that the TMP inhibited the growth of MC and the mechanism of its inhibition might be due to that TMP could reduce the IL-6. Thymidine Monophosphate 21-24 interleukin 6 Homo sapiens 130-134 7647524-4 1995 It revealed that the TMP inhibited the growth of MC and the mechanism of its inhibition might be due to that TMP could reduce the IL-6. Thymidine Monophosphate 109-112 interleukin 6 Homo sapiens 130-134 9151701-5 1997 When spermine was added to cultures of human peripheral blood mononuclear cells stimulated with lipopolysaccharide (LPS), it effectively inhibited the synthesis of the proinflammatory cytokines tumor necrosis factor (TNF), interleukin-1 (IL-1), IL-6, MIP-1alpha, and MIP-1beta. Spermine 5-13 interleukin 6 Homo sapiens 245-249 9125669-4 1997 IL-1, a physiological activator of PKC, induced a rapid increase in IL-6 messenger RNA (mRNA) levels, which was sustained at 24 h. PMA-induced IL-6 mRNA levels in RASMC were markedly attenuated after downregulation of PKC with PMA and by the selective PKC inhibitor, bisindolylmaleimide. rasmc 163-168 interleukin 6 Homo sapiens 68-72 9125669-4 1997 IL-1, a physiological activator of PKC, induced a rapid increase in IL-6 messenger RNA (mRNA) levels, which was sustained at 24 h. PMA-induced IL-6 mRNA levels in RASMC were markedly attenuated after downregulation of PKC with PMA and by the selective PKC inhibitor, bisindolylmaleimide. rasmc 163-168 interleukin 6 Homo sapiens 143-147 9125669-6 1997 Angiotensin II (Ang II), also known to activate PKC, likewise induced a rapid increase in IL-6 mRNA levels and IL-6 release in RASMC, but the effect was not blocked by PKC downregulation. rasmc 127-132 interleukin 6 Homo sapiens 111-115 30320916-8 2019 Further studies showed that interleukin 6 (IL-6) secretion increased after RKO cells were treated with vemurafenib. Vemurafenib 103-114 interleukin 6 Homo sapiens 43-47 30320916-9 2019 STAT3 activation was induced by adding IL-6 to the supernatant, and IL-6 increased STAT3 and BCL-2 expression and antagonized vemurafenib sensitivity in HT-29 cells. Vemurafenib 126-137 interleukin 6 Homo sapiens 68-72 9059324-0 1997 Down-regulation of the acute-phase response in patients with pancreatic cancer cachexia receiving oral eicosapentaenoic acid is mediated via suppression of interleukin-6. Eicosapentaenoic Acid 103-124 interleukin 6 Homo sapiens 156-169 8049434-5 1994 Of various cytokines tested, tumor necrosis factor-alpha (TNF-alpha) alone counteracted GM2- and GM3-induced inhibitions of Ig production and thymidine uptake, whereas other cytokines including IL-1 beta, IL-3, IL-5, IL-6, and interferon-gamma each failed to do so. gm3 97-100 interleukin 6 Homo sapiens 217-221 30074854-0 2019 Brain Extracellular Interleukin-6 Levels Decrease Following Antipyretic Therapy with Diclofenac in Patients with Spontaneous Subarachnoid Hemorrhage. Diclofenac 85-95 interleukin 6 Homo sapiens 20-33 7716932-3 1994 The correlations calculated between TNF-alpha and Il-6 concentrations calculated between TNF-alpha and Il-6 concentrations and laboratory parameters (laboratory indicators of hepatitis activity--AlAT; liver function indicators--prothrombin index, bilirubin concentration, bile acid concentration, alkaline phosphatase activity, anti-pyrin half-life) were non-significant in Spearman non-parametric test (p > 0.005) except for the correlation between albumin and TNF-alpha concentrations. Bilirubin 247-256 interleukin 6 Homo sapiens 50-54 9059324-5 1997 Oral supplementation with eicosapentaenoic acid, in patients with cancer cachexia, resulted in a significant reduction in the serum concentration of the acute-phase protein C-reactive protein (11.0 +/- 4.8 mg/l before eicosapentaenoic acid compared with 0.8 +/- 0.8 mg/l after 4 weeks of eicosapentaenoic acid, P < 0.05), but no significant reduction in the serum concentration of the hepatocyte-stimulating cytokine interleukin-6. Eicosapentaenoic Acid 26-47 interleukin 6 Homo sapiens 420-433 9059324-6 1997 Production of interleukin-6 by peripheral blood mononuclear cells isolated from patients was significantly reduced after supplementation with eicosapentaenoic acid (interleukin-6 production by peripheral blood mononuclear cells exposed to 10 micrograms of lipopolysaccharide/ml: 10.2 +/- 2.1 ng/ml before supplementation with eicosapentaenoic acid compared with 3.5 +/- 1.7 ng/ml after supplementation, P < 0.05) and supernatants from these cells had reduced potential to stimulate C-reactive protein production by isolated human hepatocytes (hepatocyte C-reactive protein production in response to supernatants from peripheral blood mononuclear cell cultures exposed to 10 micrograms of lipopolysaccharide/ml: 150.4 +/- 18.6 ng/ml before eicosapentaenoic acid versus 118 +/- 14.9 ng/ml after 4 weeks of eicosapentaenoic acid, P < 0.05). Eicosapentaenoic Acid 142-163 interleukin 6 Homo sapiens 14-27 9059324-6 1997 Production of interleukin-6 by peripheral blood mononuclear cells isolated from patients was significantly reduced after supplementation with eicosapentaenoic acid (interleukin-6 production by peripheral blood mononuclear cells exposed to 10 micrograms of lipopolysaccharide/ml: 10.2 +/- 2.1 ng/ml before supplementation with eicosapentaenoic acid compared with 3.5 +/- 1.7 ng/ml after supplementation, P < 0.05) and supernatants from these cells had reduced potential to stimulate C-reactive protein production by isolated human hepatocytes (hepatocyte C-reactive protein production in response to supernatants from peripheral blood mononuclear cell cultures exposed to 10 micrograms of lipopolysaccharide/ml: 150.4 +/- 18.6 ng/ml before eicosapentaenoic acid versus 118 +/- 14.9 ng/ml after 4 weeks of eicosapentaenoic acid, P < 0.05). Eicosapentaenoic Acid 142-163 interleukin 6 Homo sapiens 165-178 9059324-6 1997 Production of interleukin-6 by peripheral blood mononuclear cells isolated from patients was significantly reduced after supplementation with eicosapentaenoic acid (interleukin-6 production by peripheral blood mononuclear cells exposed to 10 micrograms of lipopolysaccharide/ml: 10.2 +/- 2.1 ng/ml before supplementation with eicosapentaenoic acid compared with 3.5 +/- 1.7 ng/ml after supplementation, P < 0.05) and supernatants from these cells had reduced potential to stimulate C-reactive protein production by isolated human hepatocytes (hepatocyte C-reactive protein production in response to supernatants from peripheral blood mononuclear cell cultures exposed to 10 micrograms of lipopolysaccharide/ml: 150.4 +/- 18.6 ng/ml before eicosapentaenoic acid versus 118 +/- 14.9 ng/ml after 4 weeks of eicosapentaenoic acid, P < 0.05). Eicosapentaenoic Acid 326-347 interleukin 6 Homo sapiens 14-27 9059324-6 1997 Production of interleukin-6 by peripheral blood mononuclear cells isolated from patients was significantly reduced after supplementation with eicosapentaenoic acid (interleukin-6 production by peripheral blood mononuclear cells exposed to 10 micrograms of lipopolysaccharide/ml: 10.2 +/- 2.1 ng/ml before supplementation with eicosapentaenoic acid compared with 3.5 +/- 1.7 ng/ml after supplementation, P < 0.05) and supernatants from these cells had reduced potential to stimulate C-reactive protein production by isolated human hepatocytes (hepatocyte C-reactive protein production in response to supernatants from peripheral blood mononuclear cell cultures exposed to 10 micrograms of lipopolysaccharide/ml: 150.4 +/- 18.6 ng/ml before eicosapentaenoic acid versus 118 +/- 14.9 ng/ml after 4 weeks of eicosapentaenoic acid, P < 0.05). Eicosapentaenoic Acid 326-347 interleukin 6 Homo sapiens 165-178 9059324-6 1997 Production of interleukin-6 by peripheral blood mononuclear cells isolated from patients was significantly reduced after supplementation with eicosapentaenoic acid (interleukin-6 production by peripheral blood mononuclear cells exposed to 10 micrograms of lipopolysaccharide/ml: 10.2 +/- 2.1 ng/ml before supplementation with eicosapentaenoic acid compared with 3.5 +/- 1.7 ng/ml after supplementation, P < 0.05) and supernatants from these cells had reduced potential to stimulate C-reactive protein production by isolated human hepatocytes (hepatocyte C-reactive protein production in response to supernatants from peripheral blood mononuclear cell cultures exposed to 10 micrograms of lipopolysaccharide/ml: 150.4 +/- 18.6 ng/ml before eicosapentaenoic acid versus 118 +/- 14.9 ng/ml after 4 weeks of eicosapentaenoic acid, P < 0.05). Eicosapentaenoic Acid 326-347 interleukin 6 Homo sapiens 14-27 9059324-6 1997 Production of interleukin-6 by peripheral blood mononuclear cells isolated from patients was significantly reduced after supplementation with eicosapentaenoic acid (interleukin-6 production by peripheral blood mononuclear cells exposed to 10 micrograms of lipopolysaccharide/ml: 10.2 +/- 2.1 ng/ml before supplementation with eicosapentaenoic acid compared with 3.5 +/- 1.7 ng/ml after supplementation, P < 0.05) and supernatants from these cells had reduced potential to stimulate C-reactive protein production by isolated human hepatocytes (hepatocyte C-reactive protein production in response to supernatants from peripheral blood mononuclear cell cultures exposed to 10 micrograms of lipopolysaccharide/ml: 150.4 +/- 18.6 ng/ml before eicosapentaenoic acid versus 118 +/- 14.9 ng/ml after 4 weeks of eicosapentaenoic acid, P < 0.05). Eicosapentaenoic Acid 326-347 interleukin 6 Homo sapiens 165-178 9059324-6 1997 Production of interleukin-6 by peripheral blood mononuclear cells isolated from patients was significantly reduced after supplementation with eicosapentaenoic acid (interleukin-6 production by peripheral blood mononuclear cells exposed to 10 micrograms of lipopolysaccharide/ml: 10.2 +/- 2.1 ng/ml before supplementation with eicosapentaenoic acid compared with 3.5 +/- 1.7 ng/ml after supplementation, P < 0.05) and supernatants from these cells had reduced potential to stimulate C-reactive protein production by isolated human hepatocytes (hepatocyte C-reactive protein production in response to supernatants from peripheral blood mononuclear cell cultures exposed to 10 micrograms of lipopolysaccharide/ml: 150.4 +/- 18.6 ng/ml before eicosapentaenoic acid versus 118 +/- 14.9 ng/ml after 4 weeks of eicosapentaenoic acid, P < 0.05). Eicosapentaenoic Acid 326-347 interleukin 6 Homo sapiens 14-27 9059324-6 1997 Production of interleukin-6 by peripheral blood mononuclear cells isolated from patients was significantly reduced after supplementation with eicosapentaenoic acid (interleukin-6 production by peripheral blood mononuclear cells exposed to 10 micrograms of lipopolysaccharide/ml: 10.2 +/- 2.1 ng/ml before supplementation with eicosapentaenoic acid compared with 3.5 +/- 1.7 ng/ml after supplementation, P < 0.05) and supernatants from these cells had reduced potential to stimulate C-reactive protein production by isolated human hepatocytes (hepatocyte C-reactive protein production in response to supernatants from peripheral blood mononuclear cell cultures exposed to 10 micrograms of lipopolysaccharide/ml: 150.4 +/- 18.6 ng/ml before eicosapentaenoic acid versus 118 +/- 14.9 ng/ml after 4 weeks of eicosapentaenoic acid, P < 0.05). Eicosapentaenoic Acid 326-347 interleukin 6 Homo sapiens 165-178 8113959-4 1994 Monocyte interleukin (IL)-1 alpha, IL-1 beta, IL-6, IL-8 and tumor necrosis factor (TNF)-alpha expression were all up-regulated after a 2-h incubation with L-MTP-PE. L-MTP-PE 156-164 interleukin 6 Homo sapiens 46-50 8283061-4 1994 When KS cells were incubated with poly (I:C) in combination with either IL-1 beta or TNF-alpha, there was a synergistic increase in the level of IL-6 production, whereas LPS and TNF-alpha in combination led to only an additive increase in the level of IL-6 production. Iodine 40-42 interleukin 6 Homo sapiens 145-149 8283061-4 1994 When KS cells were incubated with poly (I:C) in combination with either IL-1 beta or TNF-alpha, there was a synergistic increase in the level of IL-6 production, whereas LPS and TNF-alpha in combination led to only an additive increase in the level of IL-6 production. Iodine 40-42 interleukin 6 Homo sapiens 252-256 8283061-7 1994 Pretreatment of KS cells with poly (I:C) for 24 h followed by removal of the poly (I:C) led to high levels of IL-6 secreted into medium that induced proliferation in KS cells. Iodine 36-37 interleukin 6 Homo sapiens 110-114 9059324-7 1997 The potential of lipopolysaccharide-stimulated peripheral blood mononuclear cell supernatants to stimulate C-reactive protein production by hepatocytes could be attenuated by neutralizing anti-interleukin-6 antibody in control subjects and in patients before, but not after, treatment with eicosapentaenoic acid. Eicosapentaenoic Acid 290-311 interleukin 6 Homo sapiens 193-206 30074854-2 2019 In this study, we analyzed brain extracellular IL-6 levels of aSAH patients following parenteral diclofenac. Diclofenac 97-107 interleukin 6 Homo sapiens 47-51 9059324-9 1997 In conclusion, eicosapentaenoic acid can down-regulate the acute-phase response in patients with pancreatic cancer cachexia and this process is likely to involve suppression of interleukin-6 production. Eicosapentaenoic Acid 15-36 interleukin 6 Homo sapiens 177-190 11271305-0 1994 Effect of immunosuppressive agents FK 506 and cyclosporin and steroids on the expression of IL-6 and its receptor by stimulated lymphocytes and monocytes. Tacrolimus 35-41 interleukin 6 Homo sapiens 92-96 11271305-5 1994 Dexamethazone, cyclosporin (CyA), and FK 506 at immunosuppressive concentrations induced a dose-dependent inhibition of IL-6 secretion from adherent monocytes (MO) stimulated with phytohemagglutinin (PHA). Tacrolimus 38-44 interleukin 6 Homo sapiens 120-124 11271305-12 1994 FK 506, CyA, and steroids may exert their immunosuppressive effect by inhibiting IL-6 secretion and partially restoring MO IL-6R, which may be important in protecting the cell target against IL-6 autocrine stimulation. Tacrolimus 0-6 interleukin 6 Homo sapiens 81-85 11271305-12 1994 FK 506, CyA, and steroids may exert their immunosuppressive effect by inhibiting IL-6 secretion and partially restoring MO IL-6R, which may be important in protecting the cell target against IL-6 autocrine stimulation. Tacrolimus 0-6 interleukin 6 Homo sapiens 123-127 30842737-10 2019 GYY4137 and ATB-346 significantly reduced the IM-induced increase in muscular myeloperoxidase (MPO) activity and protein levels of interleukin (IL)-6, IL-1beta and monocyte chemotactic protein 1; the reduction by naproxen was less pronounced and only reached significance for MPO activity and IL-6 levels. GYY 4137 0-7 interleukin 6 Homo sapiens 293-297 8251407-2 1993 DAB389-IL-6 inhibited protein synthesis and methylcellulose colony formation by U266 myeloma cells. dab389 0-6 interleukin 6 Homo sapiens 7-11 8251407-4 1993 The specificity of killing by DAB389-IL-6 was demonstrated by inhibition of cytotoxicity by a molar excess of free rhIL-6. dab389 30-36 interleukin 6 Homo sapiens 37-41 8917348-7 1996 One mg of anti-hIL-6 antibody (MH166) also strongly inhibited the growth of S6B45, whereas control antibody (MOPC31C) and anti-hIL-6R antibody without neutralizing activity (AUK181-6) produced no significant effects. mh166 31-36 interleukin 6 Homo sapiens 15-20 8699063-5 1996 However, IL-6 release by monocytes was significantly greater after stimulation by GB-Ag than by III-PS or LTA (P < .05). iii-ps 96-102 interleukin 6 Homo sapiens 9-13 8647935-0 1996 Immunosuppressant FK506 induces interleukin-6 production through the activation of transcription factor nuclear factor (NF)-kappa(B). Tacrolimus 18-23 interleukin 6 Homo sapiens 32-45 8251407-5 1993 The effect of DAB389-IL-6 on colony formation by six OCI-My cell lines was assessed. dab389 14-20 interleukin 6 Homo sapiens 21-25 30787349-10 2019 Deferiprone blocked Poly (I:C)-induced IL-6 production by HNECs but did not alter their migration in scratch assays. Deferiprone 0-11 interleukin 6 Homo sapiens 39-43 8251407-7 1993 However, a biphasic effect was observed for the IL-6 dependent OCI-My 4 cells; DAB389-IL-6 stimulated colony formation at low (< or = 10(-11) M) concentrations, yet was inhibitory at higher doses. dab389 79-85 interleukin 6 Homo sapiens 48-52 8251407-7 1993 However, a biphasic effect was observed for the IL-6 dependent OCI-My 4 cells; DAB389-IL-6 stimulated colony formation at low (< or = 10(-11) M) concentrations, yet was inhibitory at higher doses. dab389 79-85 interleukin 6 Homo sapiens 86-90 8251407-9 1993 Flow cytometric analysis for IL-6 receptor expression using phycoerythrin-conjugated IL-6 demonstrated specific binding sites on both DAB389-IL-6 sensitive and certain insensitive cell lines, suggesting that other factors in addition to the expression of IL-6 receptors are involved in killing by the fusion toxin. dab389 134-140 interleukin 6 Homo sapiens 29-33 8251407-9 1993 Flow cytometric analysis for IL-6 receptor expression using phycoerythrin-conjugated IL-6 demonstrated specific binding sites on both DAB389-IL-6 sensitive and certain insensitive cell lines, suggesting that other factors in addition to the expression of IL-6 receptors are involved in killing by the fusion toxin. dab389 134-140 interleukin 6 Homo sapiens 85-89 8647935-4 1996 We further show that FK506 induces NF-kappaB-regulated IL-6 production in vitro and in vivo, in particular in kidney. Tacrolimus 21-26 interleukin 6 Homo sapiens 55-59 8647935-7 1996 These results thus suggest a causal relationship between FK506-induced NF-kappaB activation/IL-6 production and some of FK506-induced renal abnormalities. Tacrolimus 57-62 interleukin 6 Homo sapiens 92-96 8647935-7 1996 These results thus suggest a causal relationship between FK506-induced NF-kappaB activation/IL-6 production and some of FK506-induced renal abnormalities. Tacrolimus 120-125 interleukin 6 Homo sapiens 92-96 8817534-4 1996 Tenidap, naproxen and meloxicam inhibited the IL-1 beta-induced synthesis of IL-6, whereas ibuprofen, piroxicam, diclofenac and indomethacin had no effect. Meloxicam 22-31 interleukin 6 Homo sapiens 77-81 8251407-9 1993 Flow cytometric analysis for IL-6 receptor expression using phycoerythrin-conjugated IL-6 demonstrated specific binding sites on both DAB389-IL-6 sensitive and certain insensitive cell lines, suggesting that other factors in addition to the expression of IL-6 receptors are involved in killing by the fusion toxin. dab389 134-140 interleukin 6 Homo sapiens 85-89 8251407-9 1993 Flow cytometric analysis for IL-6 receptor expression using phycoerythrin-conjugated IL-6 demonstrated specific binding sites on both DAB389-IL-6 sensitive and certain insensitive cell lines, suggesting that other factors in addition to the expression of IL-6 receptors are involved in killing by the fusion toxin. dab389 134-140 interleukin 6 Homo sapiens 85-89 30312114-5 2019 In human myometrial cells, simvastatin reduced proinflammatory mediator mRNA and protein expression (IL-6 and IL-8) and increased anti-inflammatory cytokine mRNA expression (IL-10 and IL-13). Simvastatin 27-38 interleukin 6 Homo sapiens 101-105 8251407-12 1993 From these experiments we conclude that DAB389-IL-6 is specifically cytotoxic towards a subset of IL-6-responsive human myeloma cell lines and may be useful, in some cases, in the selective elimination of tumour cells from mixed populations of normal and malignant cells. dab389 40-46 interleukin 6 Homo sapiens 47-51 8251407-12 1993 From these experiments we conclude that DAB389-IL-6 is specifically cytotoxic towards a subset of IL-6-responsive human myeloma cell lines and may be useful, in some cases, in the selective elimination of tumour cells from mixed populations of normal and malignant cells. dab389 40-46 interleukin 6 Homo sapiens 98-102 8386318-3 1993 The JRE-IL6 element, located at -149 to -124, contains two DNA motifs, an Ets-binding site (EBS) (CAGGAAGC) and a CRE-like site (TGACGCGA). ethylbenzene 92-95 interleukin 6 Homo sapiens 8-11 8386318-5 1993 The EBS of the JRE-IL6 element (JEBS) appears to bind a protein in the Ets family or a related protein which could also form a major complex with the EBSs of the murine sarcoma virus long terminal repeat or human T-cell leukemia virus type 1 long terminal repeat. ethylbenzene 4-7 interleukin 6 Homo sapiens 19-22 8625884-1 1996 Oncastatin M (OSM) is one member of the leukemia inhibitory factor/interleukin-6 family of cytokines that has been shown to be a growth regulatory molecule. oncastatin m 0-12 interleukin 6 Homo sapiens 67-80 30647085-0 2019 CAF-Derived IL6 and GM-CSF Cooperate to Induce M2-like TAMs-Letter. cafestol palmitate 0-3 interleukin 6 Homo sapiens 12-15 8627294-4 1996 Here we show that the mixed A1 and A2 agonist 5"-(N-ethylcarboxamido) adenosine (NECA) induces an increase in IL-6 mRNA levels and protein synthesis in the human astrocytoma cell line U373 MG. Adenosine-5'-(N-ethylcarboxamide) 46-79 interleukin 6 Homo sapiens 110-114 8627294-4 1996 Here we show that the mixed A1 and A2 agonist 5"-(N-ethylcarboxamido) adenosine (NECA) induces an increase in IL-6 mRNA levels and protein synthesis in the human astrocytoma cell line U373 MG. Adenosine-5'-(N-ethylcarboxamide) 81-85 interleukin 6 Homo sapiens 110-114 8627304-3 1996 Both protein kinase C and reactive oxygen intermediates (ROIs) were involved in IL-6 and TNF alpha gene expression by IL-1 beta. reactive oxygen 26-41 interleukin 6 Homo sapiens 80-84 8726410-0 1996 Mechanisms of inhibition of IL-6-mediated immunoglobulin secretion by dexamethasone and suramin in human lymphoid and myeloma cell lines. Suramin 88-95 interleukin 6 Homo sapiens 28-32 8726410-3 1996 Previous studies in our laboratory have shown that dexamethasone and suramin inhibit cell proliferation and IL-6-mediated immunoglobulin secretion in various lymphoblastoid and myeloma cell lines. Suramin 69-76 interleukin 6 Homo sapiens 108-112 8726410-4 1996 In the present study, we present study, we present data to examine mechanisms by which dexamethasone and suramin inhibit IL-6-mediated immunoglobulin secretion in the lymphoid cell line SKW 6.4. Suramin 105-112 interleukin 6 Homo sapiens 121-125 8726410-11 1996 Using a flow cytometric assay, it is demonstrated that suramin inhibits IL-6 binding to its receptor. Suramin 55-62 interleukin 6 Homo sapiens 72-76 8726410-16 1996 Suramin interferes with IL-6 binding to its receptor and/or decreases IL-6 receptor expression. Suramin 0-7 interleukin 6 Homo sapiens 24-28 1457283-13 1992 Interleukin-6 has been shown to stimulate fibroblast synthesis of collagen and glycosaminoglycans. Glycosaminoglycans 79-97 interleukin 6 Homo sapiens 0-13 1640734-8 1992 But treatment with IL-3 plus IL-6 in conjunction with 4-HC resulted in significantly higher GSH levels in NBMMC. nbmmc 106-111 interleukin 6 Homo sapiens 29-33 1625199-6 1992 Upon stimulation with lipopolysaccharide and phytohemagglutinin, PBMC released more (P less than .01) TGF-beta, IL-6 and TNF-alpha than unstimulated PBMC. PBMC 65-69 interleukin 6 Homo sapiens 112-116 30647086-0 2019 CAF-Derived IL6 and GM-CSF Cooperate to Induce M2-like TAMs-Response. cafestol palmitate 0-3 interleukin 6 Homo sapiens 12-15 1384862-4 1992 However, the response of the PHA-pulsed T cells to IL-6 was still inhibited by FK-506 or Cs A, but the inhibitory effect gradually decreased as the time in which the PHA-pulsed T cells interacted with IL-6 was prolonged. Tacrolimus 79-85 interleukin 6 Homo sapiens 51-55 8726410-16 1996 Suramin interferes with IL-6 binding to its receptor and/or decreases IL-6 receptor expression. Suramin 0-7 interleukin 6 Homo sapiens 70-74 8550818-0 1995 Stimulation of the sphingomyelin pathway induces interleukin-6 gene expression in human astrocytoma cells. Sphingomyelins 19-32 interleukin 6 Homo sapiens 49-62 29934049-4 2019 Here we demonstrated that in human osteoblastic MG-63, U2-OS and Saos-2 cells, besides VEGF, the other two pro-angiogenic factors IL-6 and IL-8 were also up-regulated by hypoxia and CoCl2 (a mimic of hypoxia). cobaltous chloride 182-187 interleukin 6 Homo sapiens 130-134 8546810-9 1995 Addition of TSH (1 mU/ml) produced an increase in the level of IL-1 alpha mRNA in primary TFC and HTori3 cells, at 12 and 24 h. TSH had no significant effect on the expression of IL-6 or IL-8 mRNA. Thyrotropin 12-15 interleukin 6 Homo sapiens 179-183 1759822-0 1991 Differential modulation of cytokine production by macrolides: interleukin-6 production is increased by spiramycin and erythromycin. Spiramycin 103-113 interleukin 6 Homo sapiens 62-75 31418610-3 2019 Relapsed DME cases (T3) showed significantly higher levels of IL-6 (p = .028), IL-8 (p = .005), IP-10 (p = .013) and MCP-1 (p = .005) compared to T2.Conclusion: IP-10 and MCP-1 AH levels seem to be related to DEX intraocular action, decreasing after injection and increasing when DME relapses. dme 9-12 interleukin 6 Homo sapiens 62-66 1940439-4 1991 Although the effective stimulating concentrations of IL-6 were within the range (approximately 100 ng/ml) we found produced by rhIL-1 beta-treated fibroblast cultures, rhIL-1 beta at 0.2-1.0 ng/ml induced significantly greater amounts of collagen and GAG than the maximum effective concentrations of IL-6. Glycosaminoglycans 251-254 interleukin 6 Homo sapiens 53-57 1724578-0 1991 Induction of CD14 antigen on the surface of U937 cells by an interleukin-6 autocrine mechanism after culture with formalin-killed gram-negative bacteria. Formaldehyde 114-122 interleukin 6 Homo sapiens 61-74 9384667-4 1995 The neutralization of IL-6 by antibody, or IL-6 receptor antagonism by suramin, significantly reduce the severity of key parameters of cachexia. Suramin 71-78 interleukin 6 Homo sapiens 43-47 31418610-4 2019 In addition, IL-6 and IL-8 may play a role in DME late evolution and clinical relapse beyond DEX effect. dme 46-49 interleukin 6 Homo sapiens 13-17 7632461-3 1995 Cystamine, in noncytotoxic doses, suppressed in a concentration-dependent fashion the induction of HIV-1 expression mediated by TNF-alpha, IL-6, GM-CSF, and monokine-enriched monocyte culture supernatants in both U1 and ACH-2 cells as determined by HIV-1 reverse transcriptase (RT) activity. Cystamine 0-9 interleukin 6 Homo sapiens 139-143 1724578-5 1991 The U937 cells were found to produce a large amount of interleukin-6 in response to formalin-killed Salmonella enteritidis 116-54. Formaldehyde 84-92 interleukin 6 Homo sapiens 55-68 1724578-6 1991 On the other hand, culture supernatant (referred to as conditioned medium) obtained from the U937 cells after 72 h of culture with formalin-killed Salmonella enteritidis 116-54 also induced strong expression of CD14 antigen 48 to 72 h later, and this was blocked by the addition of anti-human interleukin-6 antibody. Formaldehyde 131-139 interleukin 6 Homo sapiens 293-306 30130755-5 2019 RESULTS: Serum CHI3L1 and IL-6 levels were significantly higher in DME with SRD compared to patients with CMO and DRT (p < 0.001 for all groups). dme 67-70 interleukin 6 Homo sapiens 26-30 1724578-7 1991 These findings suggest that the expression of CD14 antigen on the surface of U937 cells cultured with formalin-killed Gram-negative bacteria is induced by interleukin-6 and can be explained on the basis of the autocrine mechanism of interleukin-6. Formaldehyde 102-110 interleukin 6 Homo sapiens 155-168 1724578-7 1991 These findings suggest that the expression of CD14 antigen on the surface of U937 cells cultured with formalin-killed Gram-negative bacteria is induced by interleukin-6 and can be explained on the basis of the autocrine mechanism of interleukin-6. Formaldehyde 102-110 interleukin 6 Homo sapiens 233-246 1664173-6 1991 Conversely, the preincubation of pituitary cells with interleukin-6 for 20 min significantly reduced VIP- and forskolin-stimulated adenylate cyclase activity, as well as inositol phosphate production and free cytosolic calcium increase induced by TRH. Inositol Phosphates 170-188 interleukin 6 Homo sapiens 54-67 7487139-6 1995 HDF production of interleukin (IL)-6 increased in response to the PGI1 analogues. pgi1 66-70 interleukin 6 Homo sapiens 18-36 7487139-7 1995 Since IL-6 was shown to promote cell growth of NHKs, enhancement of NHK proliferation by CM was thought to be due to IL-6 derived from HDFs stimulated with the PGI1 analogues. pgi1 160-164 interleukin 6 Homo sapiens 117-121 30130755-6 2019 Multivariate regression analysis showed that CHI3L1 and IL-6 had a stronger influence on the presence of SRD in DME (r = 1.162, p = 0.026, and r = 1.242, p = 0.016, respectively). dme 112-115 interleukin 6 Homo sapiens 56-60 7664026-0 1995 Circulating interleukin 10 and interleukin-6 serum levels in rheumatoid arthritis patients treated with methotrexate or gold salts: preliminary report. gold salts 120-130 interleukin 6 Homo sapiens 31-44 30130755-8 2019 CONCLUSIONS: Our data suggest that serum concentrations of CHI3L1 and IL-6 are involved in the process of SRD in DME. dme 113-116 interleukin 6 Homo sapiens 70-74 1864014-2 1991 After 7 days of ciprofloxacin, the extracellular and cellular production of TNF-alpha, the cellular production of IL-1 activity, the extracellular and cellular production of IL-1 alpha, and the cellular production of IL-6 increased significantly. Ciprofloxacin 16-29 interleukin 6 Homo sapiens 217-221 2044224-4 1991 IL-6 levels were higher in patients who died (P = 0.04) and correlated with the features of severe disease including: increased grade of encephalopathy, increased neutrophil count, increased prothrombin ratio, hypotension, increased serum creatinine and increased serum bilirubin. Bilirubin 270-279 interleukin 6 Homo sapiens 0-4 7623608-1 1995 The effects of elevated glucose and eicosapentaenoic acid (EPA, C20:5 omega 3) on myo-inositol uptake in human skin fibroblasts (HSF) were evaluated. Eicosapentaenoic Acid 59-62 interleukin 6 Homo sapiens 129-132 8063416-2 1994 PBMC and Mphi from all these donor groups secreted increased levels of tumor necrosis factor alpha, interleukin-1 beta, and interleukin-6 in response to stimulation with formalin-killed spherules (FKS), as measured by enzyme-linked immunosorbent assays. Formaldehyde 170-178 interleukin 6 Homo sapiens 124-137 29457379-8 2018 Subjects with urate deposits had higher IL-6 (257.2 versus 47.0 pg/ml; P = 0.005), IL-8 (73.2 versus 12.0 pg/ml; P = 0.026), and miR-155 (0.21 versus 0.16; P = 0.015) levels than those without deposition findings. Uric Acid 14-19 interleukin 6 Homo sapiens 40-44 7519668-8 1994 Both histamine and SP enhanced the formation of inositol phosphates and increase intracellular calcium levels, suggesting that the phosphatidylinositol bisphosphate/protein kinase C pathway may be involved in the IL-6 release process. Inositol Phosphates 48-67 interleukin 6 Homo sapiens 213-217 2049864-3 1991 In three patients with Castleman"s disease, in whom serum interleukin 6 (IL-6) levels were elevated, agalactosyl species of serum IgG oligosaccharides were markedly increased as compared to those of normal healthy controls. Oligosaccharides 134-150 interleukin 6 Homo sapiens 58-71 2049864-3 1991 In three patients with Castleman"s disease, in whom serum interleukin 6 (IL-6) levels were elevated, agalactosyl species of serum IgG oligosaccharides were markedly increased as compared to those of normal healthy controls. Oligosaccharides 134-150 interleukin 6 Homo sapiens 73-77 2049864-4 1991 A close relationship between increased IL-6 and altered IgG oligosaccharide structure is suggested. Oligosaccharides 60-75 interleukin 6 Homo sapiens 39-43 7811548-0 1994 Inhibition of AIDS-associated Kaposi"s sarcoma cell growth by DAB389-interleukin 6. dab389 62-68 interleukin 6 Homo sapiens 69-82 29457379-9 2018 CONCLUSION: In individuals with chronic asymptomatic hyperuricemia, the presence of synovitis and double contour sign by US may represent a subclinical manifestation of monosodium urate crystal nucleation, capable of triggering inflammatory pathways (IL-6 and IL-8) and mechanisms of intercellular communication (miR-155), similar to what is observed in patients with gout. Uric Acid 169-185 interleukin 6 Homo sapiens 251-255 30279279-6 2018 Co-inhibition of LMP7 and LMP2 with PRN1126 and LMP2 inhibitors LU-001i or ML604440 impairs MHC class I cell surface expression, IL-6 secretion, and differentiation of naive T helper cells to T helper 17 cells, and strongly ameliorates disease in experimental colitis and EAE. lu-001i 64-71 interleukin 6 Homo sapiens 129-133 7959542-5 1994 IL-6-M correlated significantly with the maximum concentration of total bilirubin and with the postoperative decrease in AKBR. Bilirubin 72-81 interleukin 6 Homo sapiens 0-4 2050247-3 1991 However, IL-6 alone induced significant proliferation of mature cortisone-resistant thymocytes, whereas IL-1 did not. Cortisone 64-73 interleukin 6 Homo sapiens 9-13 1989890-4 1991 Therefore, only KU 812 and MEG-01 coexpress both IL-6 and IL-6-R. ku 812 16-22 interleukin 6 Homo sapiens 49-53 1989890-4 1991 Therefore, only KU 812 and MEG-01 coexpress both IL-6 and IL-6-R. meg-01 27-33 interleukin 6 Homo sapiens 49-53 1814850-4 1991 Aspirin, ibuprofen, and phenylbutazone also inhibited IL-6 production by adherent cells stimulated with lipopolysaccharide (LPS). Phenylbutazone 24-38 interleukin 6 Homo sapiens 54-58 30582854-20 2018 CONCLUSIONS: The decreased adiponectin level and elevated levels of TNF-alpha and IL-6 in the ChNPP ACUW of a<<iodine>> period having got the T2DM are the meaningful factors in progression of LV geometric remodeling. Iodine 117-123 interleukin 6 Homo sapiens 82-86 1700795-7 1990 Low CldAdo concentrations (5-20 nM) inhibited monocyte phagocytosis and reduced the release of interleukin 6. Cladribine 4-10 interleukin 6 Homo sapiens 95-108 7938085-5 1994 Here the authors present data which suggests that PGs including thromboxane B2 (TXB2) and their precursors such as dihomo-gamma linolenic acid (DGLA), arachidonic acid (AA) and eicosapentaenoic acid (EPA) can inhibit T-cell proliferation and influence their ability to secrete IL-2, IL-4, IL-6 and TNF in vitro. Eicosapentaenoic Acid 177-198 interleukin 6 Homo sapiens 289-293 30481900-0 2018 [Relationships between the levels of serum 25-hydroxyvitamin D and interleukin-6 in patients with Takayasu"s arteritis]. 25-hydroxyvitamin D 43-62 interleukin 6 Homo sapiens 67-80 7942325-9 1994 Interleukin-6 (IL-6) synthesis was not affected by aceclofenac while it was diminished by diclofenac. Diclofenac 90-100 interleukin 6 Homo sapiens 0-13 8199014-3 1994 Co-stimulation with A23187 plus PMA resulted in an up-regulation of M-CSF mRNA and a down-regulation of IL-6 mRNA. Calcimycin 20-26 interleukin 6 Homo sapiens 104-108 8199014-4 1994 Conversely co-stimulation with A23187 plus DBcAMP resulted in a down-regulation of M-CSF mRNA and an up-regulation of IL-6 mRNA. Calcimycin 31-37 interleukin 6 Homo sapiens 118-122 1699434-6 1990 Appreciable amounts of immunoreactive IL-1 and IL-6 were indeed recovered in the supernatants of TDI-exposed epithelial cells. Toluene 2,4-Diisocyanate 97-100 interleukin 6 Homo sapiens 47-51 2191052-3 1990 The hallmark of IL-6 gene regulation is its induction by inflammation-associated cytokines, bacterial products, virus infection, and activation of any of the three major signal transduction pathways (diacylglycerol-, cAMP-, and Ca(++)-activated). Diglycerides 200-214 interleukin 6 Homo sapiens 16-20 30483128-7 2018 In addition, taxifolin alleviated ovariectomized-induced bone loss by repressing osteoclast activity and decreasing serum levels of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6 and receptor activator of nuclear factor-kappaB ligand (RANKL) in vivo. taxifolin 13-22 interleukin 6 Homo sapiens 180-248 2107353-7 1990 However, when PDGF-BB or -AB was combined with IL-1 beta or IL-6, prostanoid generation by HMC was synergistically increased up to 222-fold (IL-1 beta) or 12-fold (IL-6) above the control values, with the induction of PGE2 greater than 6-keto-PGF1 alpha greater than PGF2 alpha much greater than TXB2. Dinoprost 267-271 interleukin 6 Homo sapiens 60-64 2103309-6 1990 This activity was increased (1.7 to 2.6-fold) when SMC were pretreated with IL-1 or calcium ionophore A23187 for 48 h, and was completely blocked by rabbit anti-human IL-6 antibodies. Calcimycin 102-108 interleukin 6 Homo sapiens 167-171 8274481-9 1994 Cells incubated with interleukin-6 had a 31% increase in sterol synthesis rate but a 41% decrease in sterol secretion. Sterols 57-63 interleukin 6 Homo sapiens 21-34 7507316-6 1993 For instance, CsA and FK 506 inhibit the transcription of IL-3, IL-4, IFN gamma, TNF alpha or GM-CSF by activated T cells, and rapamycin has been shown to block the response to various growth factors such as IL-3, IL-4 or IL-6. Tacrolimus 22-28 interleukin 6 Homo sapiens 222-226 1688564-6 1990 In addition, stimulators of protein kinase C, including phorbol esters and teleocidin, enhanced accumulation of IL-6 mRNA. teleocidins 75-85 interleukin 6 Homo sapiens 112-116 30233734-11 2018 miR-365 may regulate the occurrence and immune response of sepsis following multiple trauma via IL-6. mir-365 0-7 interleukin 6 Homo sapiens 96-100 33236262-5 2021 Results demonstrated that ISACN negatively modulated the production of inflammatory cytokines IL-1beta, TNF-alpha, and IL-6 by cultured macrophages. isacn 26-31 interleukin 6 Homo sapiens 119-123 8280710-8 1993 Following L-MTP-PE infusion, induction of circulating TNF-alpha, IL-6, neopterin, and C-reactive protein was demonstrated. L-MTP-PE 10-18 interleukin 6 Homo sapiens 65-69 8403509-3 1993 Given that fever is often a prominent feature of hypersensitivity, we also assessed whether SMX or SMX-HA could induce the in vitro production of IL-1 beta, IL-6 or tumour necrosis factor-alpha (TNF-alpha) by PBMC. sulfamethoxazole hydroxylamine 99-105 interleukin 6 Homo sapiens 157-161 8506265-0 1993 Site-directed and deletion mutational analysis of the receptor binding domain of the interleukin-6 receptor targeted fusion toxin DAB389-IL-6. dab389 130-136 interleukin 6 Homo sapiens 85-98 8506265-0 1993 Site-directed and deletion mutational analysis of the receptor binding domain of the interleukin-6 receptor targeted fusion toxin DAB389-IL-6. dab389 130-136 interleukin 6 Homo sapiens 137-141 8506265-1 1993 We have used site-directed and in-frame deletion mutational analysis in order to explore the structural features of the IL-6 portion of the diphtheria toxin-related interleukin-6 (IL-6) fusion toxin DAB389-IL-6 that are essential for receptor-binding and subsequent inhibition of protein synthesis in target cells. dab389 199-205 interleukin 6 Homo sapiens 120-124 33785949-1 2021 OBJECTIVE: To investigate the relationship between vitamin C intake and IL-6 level as a biomarker of oxidative stress during pregnancy. Ascorbic Acid 51-60 interleukin 6 Homo sapiens 72-76 33146542-6 2021 Exposing hPACs and PAC 266-6 to pro-inflammatory cytokines (hyper IL-6, TNF-alpha, and IL-1beta) was found to lead to a significant inhibition in thiamin uptake. hpacs 9-14 interleukin 6 Homo sapiens 66-70 8506265-1 1993 We have used site-directed and in-frame deletion mutational analysis in order to explore the structural features of the IL-6 portion of the diphtheria toxin-related interleukin-6 (IL-6) fusion toxin DAB389-IL-6 that are essential for receptor-binding and subsequent inhibition of protein synthesis in target cells. dab389 199-205 interleukin 6 Homo sapiens 165-178 29779217-3 2018 Ginsenoside C-Mx alleviated UVB-induced intracellular reactive oxygen species (ROS), MMP-1 and IL-6 expression while accelerating TGF-beta and procollagen type I secretion. ginsenoside c-mx 0-16 interleukin 6 Homo sapiens 95-99 8506265-1 1993 We have used site-directed and in-frame deletion mutational analysis in order to explore the structural features of the IL-6 portion of the diphtheria toxin-related interleukin-6 (IL-6) fusion toxin DAB389-IL-6 that are essential for receptor-binding and subsequent inhibition of protein synthesis in target cells. dab389 199-205 interleukin 6 Homo sapiens 180-184 8506265-1 1993 We have used site-directed and in-frame deletion mutational analysis in order to explore the structural features of the IL-6 portion of the diphtheria toxin-related interleukin-6 (IL-6) fusion toxin DAB389-IL-6 that are essential for receptor-binding and subsequent inhibition of protein synthesis in target cells. dab389 199-205 interleukin 6 Homo sapiens 180-184 8506265-4 1993 In addition, we explored the relative role of the disulfide bridges within the IL-6 portion of DAB389-IL-6 in the stabilization of structure required for receptor-binding. dab389 95-101 interleukin 6 Homo sapiens 79-83 8506265-4 1993 In addition, we explored the relative role of the disulfide bridges within the IL-6 portion of DAB389-IL-6 in the stabilization of structure required for receptor-binding. dab389 95-101 interleukin 6 Homo sapiens 102-106 33233806-11 2020 IL-6 showed 73.1% sensitivity, 80.2% specificity, 37.6% PPV, and 94.8% NPV. DOP protocol 56-59 interleukin 6 Homo sapiens 0-4 30186882-0 2018 Effects of Systemic Simvastatin on the Concentrations of Visfatin, Tumor Necrosis Factor-alpha, and Interleukin-6 in Gingival Crevicular Fluid in Patients with Type 2 Diabetes and Chronic Periodontitis. Simvastatin 20-31 interleukin 6 Homo sapiens 100-113 29743070-6 2018 Proliferation and cytokine release (IL-6 and CXCL8) of ASM was induced by FCS, and measured by bromodeoxyuridine incorporation and ELISA, respectively. Bromodeoxyuridine 95-112 interleukin 6 Homo sapiens 36-40 8387831-6 1993 The inhibition of tumor necrosis factor alpha and interleukin-6 release from mononuclear leukocytes was inhibited by a combination of osmolality and monosaccharide concentration. Monosaccharides 149-163 interleukin 6 Homo sapiens 50-63 1327882-2 1992 Both receptor-binding and immunoglobulin (Ig)-induction activities of a triple mutant Leu168,175,182-->Val were only 1% compared with those of wild-type IL-6. Valine 106-109 interleukin 6 Homo sapiens 156-160 29627199-6 2018 Significantly increased IL-4, IL-5, IL-6, IL-10, tumor necrosis factor-alpha and IFN-gamma/IL-4 were found in the RAU group. rau 114-117 interleukin 6 Homo sapiens 36-40 1516257-5 1992 Peripheral blood mononuclear cells (PBMC) from untreated patients produced IL-1 beta, tumour necrosis factor-alpha (TNF-alpha) and IL-6 in response to mitogenic stimulation with phytohaemagglutinin (PHA), only low levels of IL-1 beta, IL-2 and TNF-alpha in response to OvAg, but higher amounts of IL-4 and interferon-gamma (IFN-gamma) in response to OvAg than control individuals. ovag 269-273 interleukin 6 Homo sapiens 131-135 22302227-10 2012 In the treatment group, plasma placental growth factor (PlGF) increased and IL-6 decreased after 12 weeks of ADT. adt 109-112 interleukin 6 Homo sapiens 76-80 20218345-8 2010 CONCLUSION: LX inhibits TLR-mediated production of both proinflammatory (IL-1, IL-6, IL-8, IL-12, TNFalpha) and anti-inflammatory (IL-10) cytokinesby PBMC of healthy subjects in vitro. lx 12-14 interleukin 6 Homo sapiens 79-83 34078115-6 2022 IL-6 inhibitors (sirukumab, tocilizumab, sarilumab) significantly enhance metabolism via CYP2C9 (s-warfarin), CYP2C19 (omeprazole), and CYP3A4 (simvastatin, midazolam) and reduce metabolism via CYP1A2 (caffeine). Simvastatin 144-155 interleukin 6 Homo sapiens 0-4 1516257-5 1992 Peripheral blood mononuclear cells (PBMC) from untreated patients produced IL-1 beta, tumour necrosis factor-alpha (TNF-alpha) and IL-6 in response to mitogenic stimulation with phytohaemagglutinin (PHA), only low levels of IL-1 beta, IL-2 and TNF-alpha in response to OvAg, but higher amounts of IL-4 and interferon-gamma (IFN-gamma) in response to OvAg than control individuals. ovag 350-354 interleukin 6 Homo sapiens 131-135 29508465-7 2018 Knockdown of Nrf2 attenuated the effect of casticin on production of IL-6 and IL-8, expression of MUC5AC, collagen type I, and fibronectin in 16-HBE cells. casticin 43-51 interleukin 6 Homo sapiens 69-73 29932110-6 2018 Of these, only (2-(1,2-diphenyl-1H-indol-3-yl)ethanamine (DPIE) showed a synergistic increase in inflammatory molecules and cytokine production (IL-6, IL-8, and COX-2) at both mRNA and protein levels in IL-1&beta;-stimulated GFs. 1,2-Diphenyltryptamine 16-56 interleukin 6 Homo sapiens 145-149 1639101-5 1992 The tumor growth inhibition in vivo was also observed by administration of the anti-human IL-6 antibody MH166 using the same procedure as for PM1. mh166 104-109 interleukin 6 Homo sapiens 90-94 1639344-5 1992 Furthermore, ursodeoxycholic acid suppressed interleukin-2 and interleukin-4 production induced by concanavalin A and interferon-gamma production induced by polyinosinic-polycytidylic acid, but it did not affect interleukin-1 and interleukin-6 production induced by lipopolysaccharide in peripheral blood mononuclear cells. Ursodeoxycholic Acid 13-33 interleukin 6 Homo sapiens 230-243 34750969-7 2022 RESULTS: Mean IL6 value in KD was 83.22 pg/mL and in MISC 199.91 pg/mL, which was not found to be statistically significant (P = .322 > .05).However mean NT-proBNP (914.91 pg/mL) with CRP level (96.32 mg/L) in KD was significantly lower (P < .05 for both cases) than that in MISC (9141.16 pg/mL and 145.66 mg/L respectively). nt-probnp 154-163 interleukin 6 Homo sapiens 14-17 29914535-5 2018 RESULTS: After the bone cut and surgery, TXA significantly increased MCP-1, TNF-alpha, IL-1beta and IL-6 levels compared to non-TXA patients, which was further amplified postoperatively. Tranexamic Acid 41-44 interleukin 6 Homo sapiens 100-104 34709564-9 2022 Furthermore, pharmacological inhibition with TAK 242 (1 microM) and transfection with TLR4 small interfering RNA resulted in significant reduction in TNF-alpha and IL-6 production in S1-stimulated BV-2 microglia. ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate 45-52 interleukin 6 Homo sapiens 164-168 34904269-3 2022 This study was conducted to evaluate the expression of selected cytokine (IL1B, IL2, IL6, IL10, TNF, TGFB1, IFNG) and Toll-like receptor (TLR2) genes in lymphocytes isolated from whole human blood infected with S. aureus Newman strain treated with TA. anethole 248-250 interleukin 6 Homo sapiens 85-88 34904269-6 2022 The lymphocytes isolated from the blood infected with TA-treated staphylococcal cells demonstrated significantly greater IL10, IL1B, IL6, TNF and TLR2 expression. anethole 54-56 interleukin 6 Homo sapiens 133-136 34883184-7 2022 Chiglitazar administration led to significant improvement in insulin resistance/insulin secretion (HOMA-IR, HOMA-IS), interleukin-6 (IL-6), prostaglandin F2alpha (PGF-2alpha), 17-hydroxyprogesterone (17-OHP) and adiponectin (ADP) score values compared with sitagliptin administration. chiglitazar 0-11 interleukin 6 Homo sapiens 118-131 34883184-7 2022 Chiglitazar administration led to significant improvement in insulin resistance/insulin secretion (HOMA-IR, HOMA-IS), interleukin-6 (IL-6), prostaglandin F2alpha (PGF-2alpha), 17-hydroxyprogesterone (17-OHP) and adiponectin (ADP) score values compared with sitagliptin administration. chiglitazar 0-11 interleukin 6 Homo sapiens 133-137 1634921-8 1992 RESULTS: After the infusion of L-MTP-PE, there was rapid induction of circulating TNF alpha and IL-6. L-MTP-PE 31-39 interleukin 6 Homo sapiens 96-100 1634921-10 1992 Induction of circulating TNF alpha and IL-6 was evident only after the first dose of L-MTP-PE. L-MTP-PE 85-93 interleukin 6 Homo sapiens 39-43 30008606-8 2018 ETMI exerted its anti-inflammatory activity by modulating the main inflammatory indicators such as cyclooxygenase (COX)-2, interleukin (IL)-6, inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)-alpha, and nitric oxide (NO) in a dose-dependent manner. etmi 0-4 interleukin 6 Homo sapiens 123-141 1790549-2 1991 When PBMCs were cultured with propentofylline in vitro, the production of IL-6 was markedly increased at concentrations of 0.1 to 3.0 mmol/L of propentofylline and the production of IL-1 beta was slightly increased at concentrations of 1.0 to 3.0 mmol/L. propentofylline 30-45 interleukin 6 Homo sapiens 74-78 1790549-2 1991 When PBMCs were cultured with propentofylline in vitro, the production of IL-6 was markedly increased at concentrations of 0.1 to 3.0 mmol/L of propentofylline and the production of IL-1 beta was slightly increased at concentrations of 1.0 to 3.0 mmol/L. propentofylline 144-159 interleukin 6 Homo sapiens 74-78 1790549-4 1991 When the effects of propentofylline on the production of IL-6, IL-1 beta, and TNF-alpha by OK-432-stimulated PBMCs were examined, IL-6 secretion was not significantly increased, whereas production of IL-1 beta and TNF-alpha were significantly suppressed in a dose-dependent manner. propentofylline 20-35 interleukin 6 Homo sapiens 57-61 1790549-5 1991 The results demonstrate that propentofylline has a differential effect on the production of IL-6, IL-1 beta, and TNF-alpha by PBMCs, and it is proposed that propentofylline may exert pharmacologic actions on the regulation of the production of cytokines in the central nervous system. propentofylline 29-44 interleukin 6 Homo sapiens 92-96 1790549-5 1991 The results demonstrate that propentofylline has a differential effect on the production of IL-6, IL-1 beta, and TNF-alpha by PBMCs, and it is proposed that propentofylline may exert pharmacologic actions on the regulation of the production of cytokines in the central nervous system. propentofylline 157-172 interleukin 6 Homo sapiens 92-96 34180760-15 2021 This study provides a theoretical basis for elucidating the mechanism of mepivacaine-induced nerve cell damage, and overexpressed miR-183-5p likely become a novel strategy to combat mepivacaine-induced nerve damage.Abbreviations:miRNA: Micro RNA; PDCD4: Programmed Cell Death 4; MDA: Malondialdehyde; SOD: Superoxide Dismutase; ROS: Reactive Oxygen Species; WT: Wild Type; Mut: Mutant; UTR: Untranslated Region; IL-6: Interleukin-6; IL-1beta: Interleukin-1beta; TNF-alpha: Tumor Necrosis Factor-alpha; IL-8: Interleukin-8; COX-2: Cyclooxygenase-2; iNOS: inducible NOS; MEP: Mepivacaine. mir-183-5p 130-140 interleukin 6 Homo sapiens 412-416 34180760-15 2021 This study provides a theoretical basis for elucidating the mechanism of mepivacaine-induced nerve cell damage, and overexpressed miR-183-5p likely become a novel strategy to combat mepivacaine-induced nerve damage.Abbreviations:miRNA: Micro RNA; PDCD4: Programmed Cell Death 4; MDA: Malondialdehyde; SOD: Superoxide Dismutase; ROS: Reactive Oxygen Species; WT: Wild Type; Mut: Mutant; UTR: Untranslated Region; IL-6: Interleukin-6; IL-1beta: Interleukin-1beta; TNF-alpha: Tumor Necrosis Factor-alpha; IL-8: Interleukin-8; COX-2: Cyclooxygenase-2; iNOS: inducible NOS; MEP: Mepivacaine. mir-183-5p 130-140 interleukin 6 Homo sapiens 418-431 29622397-14 2018 Additionally, IP GYY4137 allowed for significant attenuation of inflammatory chemokine production of IL-6, IP-10 and MIP-2. GYY 4137 17-24 interleukin 6 Homo sapiens 101-105 34459104-8 2021 Treatment of HFLS-RA cells with OMTH prevented TNF-alpha mediated elevation of IL-1beta, IL-6 and IL-8. omth 32-36 interleukin 6 Homo sapiens 89-93 1718855-4 1991 To explain this phenomenon, the serum hIL-6 level was monitored following the MH166 administration. mh166 78-83 interleukin 6 Homo sapiens 38-43 1718855-5 1991 The hIL-6 level was significantly higher in the mice treated with both hIL-6 and MH166 than in the mice treated with hIL-6 alone during the 24 hr following hIL-6 administration. mh166 81-86 interleukin 6 Homo sapiens 4-9 1718855-6 1991 These results indicate that MH166 prolongs half-life of a xenogeneic hIL-6. mh166 28-33 interleukin 6 Homo sapiens 69-74 29960844-7 2018 Pretreatment with salidroside markedly inhibited the production levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and IL-6 in a dose-dependent manner. rhodioloside 18-29 interleukin 6 Homo sapiens 148-152 1864014-0 1991 Ciprofloxacin treatment in vivo increases the ex vivo capacity of lipopolysaccharide-stimulated human monocytes to produce IL-1, IL-6 and tumour necrosis factor-alpha. Ciprofloxacin 0-13 interleukin 6 Homo sapiens 129-133 2011918-6 1991 Interleukin 6 (10(4)-10(5) U/l) inhibited TSH-induced thyroid peroxidase mRNA in a dose-dependent manner, although the basal level of thyroid peroxidase mRNA expression was not suppressed by interleukin 6. Thyrotropin 42-45 interleukin 6 Homo sapiens 0-13 2011918-6 1991 Interleukin 6 (10(4)-10(5) U/l) inhibited TSH-induced thyroid peroxidase mRNA in a dose-dependent manner, although the basal level of thyroid peroxidase mRNA expression was not suppressed by interleukin 6. Thyrotropin 42-45 interleukin 6 Homo sapiens 191-204 2011918-9 1991 Subsequently, interleukin 6 inhibited TSH-induced T3 secretion in a dose-dependent manner after 72 h treatment. Thyrotropin 38-41 interleukin 6 Homo sapiens 14-27 34076913-6 2021 ELISA of BALF validated that ANI 654-2 decreased TNF-alpha, IL-1beta, IL-6 and IL-18 while increased IL-10. 1-Naphthylisothiocyanate 29-32 interleukin 6 Homo sapiens 70-74 34716863-9 2021 To assess the function of JAK2/STAT3 signaling, HUVECs were treated with UA, and the phosphorylation levels of JAK2, STAT3, IL-6 and SOCS3 were increased by a high concentration of UA. Uric Acid 181-183 interleukin 6 Homo sapiens 124-128 29653746-11 2018 Additionally, IL-6 pre-treatment followed by exposure to SRT1720 and NVP-BEZ235 significantly increased sensitivity of the cancer stem cells to radiation (p < 0.05). dactolisib 73-79 interleukin 6 Homo sapiens 14-18 34867348-5 2021 In an epithelial cell culture model, RG0216 significantly decreased LPS-induced interleukin (IL)-6 and IL-1beta gene and protein expression and was as effective as equimolar concentrations of deprenyl (an existing irreversible MAO-B inhibitor). rg0216 37-43 interleukin 6 Homo sapiens 80-98 34859062-16 2021 Finally, we found that DFD significantly increased the level of SIRT1 and reduced the levels of ACE, VCAM-1, and IL-6. diformyl dapsone 23-26 interleukin 6 Homo sapiens 113-117 34754315-10 2021 Molecular docking results showed that quercetin, luteolin, kaempferol, tanshinone IIa, wogonin, naringenin, nobiletin, dihydrotanshinlactone, beta-sitosterol, and salviolone have good affinity with core target proteins IL6, PTGS2, MAPK1, MAPK3, and CGRP1. kaempferol 59-69 interleukin 6 Homo sapiens 219-222 1663395-9 1991 Cytokines, such as gamma-interferon, interleukin-1, and interleukin-6 have been shown to inhibit the TSH-induced increase of TPO mRNA, but further investigations are required to elucidate the exact role of cytokines in the regulation of M/TPO-Ag expression. Thyrotropin 101-104 interleukin 6 Homo sapiens 56-69 2188060-2 1990 The hallmark of IL-6 gene regulation is its induction in many different tissues by inflammation-associated cytokines, bacterial products, virus infection and by activation of any of the three major signal transduction pathways (diacylglycerol, cAMP and Ca2(+)-activated). Diglycerides 228-242 interleukin 6 Homo sapiens 16-20 29861487-5 2018 In study 1 (male: n = 242; 53%), plasma IL-6, TNFalpha and CRP were significantly higher (p < 0.05) in children with 25-hydroxyvitamin D (25(OH)D) >= 75 nmol/L compared to. 25-hydroxyvitamin D 120-139 interleukin 6 Homo sapiens 40-44 2294996-8 1990 However, on a molar basis PBMC produced approximately two to three times less IL-6 than IL-1 alpha, IL-1 beta, or TNF, regardless of the stimulus. PBMC 26-30 interleukin 6 Homo sapiens 78-82 34746302-16 2021 The hub components possibly include quercetin, stigmasterol, kaempferol, and beta-sitosterol and act through pairing with hub targets, such as AKT1, VEGFA, and IL6, to regulate neuronal death, G protein-coupled amine receptor activity, reactive oxygen species metabolic process, membrane raft, MAPK signaling pathway, and cellular senescence for the treatment of PD. kaempferol 61-71 interleukin 6 Homo sapiens 160-163 34549226-0 2021 25-Hydroxyvitamin D status is associated with interleukin-6 methylation in adipose tissue from patients with colorectal cancer. 25-hydroxyvitamin D 0-19 interleukin 6 Homo sapiens 46-59 33808148-4 2021 Indeed, it was found in keratinocytes that carotenoids and polyphenols inhibit UVB-induced NFkappaB activity and release of cytokine IL-6. Carotenoids 43-54 interleukin 6 Homo sapiens 133-137 29875665-10 2018 The GLPG and/or SHB treatments restored the inhibitory effects of acetate on IL-6 and IL-8 production and the inhibitory effects of butyrate or propionate on IL-6 production, but not on IL-8. Acetates 66-73 interleukin 6 Homo sapiens 77-81 33808148-7 2021 Inflammatory cytokines such as IL-6 and TNFalpha induce the expression of matrix metalloproteinases (MMPs), which leads to collagen breakdown; thus, it is important to note that carnosic acid reduced TNFalpha-induced MMP-1 secretion from human dermal fibroblasts. salvin 178-191 interleukin 6 Homo sapiens 31-35 33798967-9 2021 The results of the autopsy and laboratory tests in the present cases and those of cultured cell experiments indicated that CNS disorders caused by CNS stimulants such as amphetamines led to changes in IL-6 as an immune response, which suggests that IL-8 may help protect nerve cells in cases involving heat stroke and stimulants. Amphetamines 170-182 interleukin 6 Homo sapiens 201-205 34590836-7 2021 Also, we found that AZ3451 attenuated ox-LDL-induced expression and production of pro-inflammatory cytokines such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and interleukin-8 (IL-8). AZ3451 20-26 interleukin 6 Homo sapiens 117-130 34590836-7 2021 Also, we found that AZ3451 attenuated ox-LDL-induced expression and production of pro-inflammatory cytokines such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and interleukin-8 (IL-8). AZ3451 20-26 interleukin 6 Homo sapiens 132-136 29875665-14 2018 Conclusion: Activation of GPR41/43 mediates the effects of acetate on IL-6 and IL-8 production and the effects of butyrate and propionate on IL-6 production. Acetates 59-66 interleukin 6 Homo sapiens 70-74 29486150-2 2018 Thus, recently we synthesized novel paullone-like scaffold, 5H-benzo [2, 3][1,4]oxazepino[5,6-b]indoles, where compounds 13a and 14a attenuated the growth of liver cancer specific Hep-G2 cells in vitro and formed stable binding complex with IL-6. 5h-benzo [2, 3][1,4]oxazepino[5,6-b]indoles 60-103 interleukin 6 Homo sapiens 241-245 29389739-4 2018 The results showed that under noncontacting conditions, simvastatin could reduce the proliferation, apoptosis, and TNF-alpha, IL-6, and vascular endothelial growth factor secretion both in VSMC and macrophage, which is induced by TNF-alpha-activated EC. Simvastatin 56-67 interleukin 6 Homo sapiens 126-130 34655103-11 2022 LPS exposure evoked viability reduction, increased LDH release and apoptosis, and induced production of inflammatory cytokines (IL-6, IL-8, and MCP-1) and MUC5AC hypersecretion in human AECs, which were alleviated by euxanthone. euxanthone 217-227 interleukin 6 Homo sapiens 128-132 34608242-7 2021 Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them. Sphingomyelins 30-43 interleukin 6 Homo sapiens 173-186 34608242-7 2021 Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them. Sphingomyelins 30-43 interleukin 6 Homo sapiens 188-192 34608242-7 2021 Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them. Sphingomyelins 45-47 interleukin 6 Homo sapiens 173-186 26246181-0 2016 Poly-L-Arginine Acts Synergistically with LPS to Promote the Release of IL-6 and IL-8 via p38/ERK Signaling Pathways in NCI-H292 Cells. polyarginine 0-15 interleukin 6 Homo sapiens 72-76 26335632-8 2015 IL-6 and IFNgamma were downregulated in HMGECs treated for 72 h with DHA and EPA. Eicosapentaenoic Acid 77-80 interleukin 6 Homo sapiens 0-4 26335632-9 2015 In general, TNFalpha, IFNgamma and IL-6 levels were decreased after 72 h compared to 24 h in serum containing medium with or without DHA or EPA. Eicosapentaenoic Acid 140-143 interleukin 6 Homo sapiens 35-39 34493195-7 2022 RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients. kaempferol 159-169 interleukin 6 Homo sapiens 251-254 29616124-4 2018 Incubation with sodium citrate for 24 h revealed that the levels of interleukin-1beta (IL-1beta), IL-8 and tumor necrosis factor increased with an increasing of dose of sodium citrate, whereas the IL-6 levels exhibited only a slight alteration. Sodium Citrate 16-30 interleukin 6 Homo sapiens 197-201 34445661-6 2021 The ADA inhibitor DAA significantly reduced IL-6 and induced IL-10 in both OA and RA cells. daa 18-21 interleukin 6 Homo sapiens 44-48 26640530-14 2015 Concentrations of IL-1beta, IL-6 and CRP were significantly higher in patients who developed POCD on day 1 following surgery than in the patients who did not develop POCD (P<0.05). pocd 93-97 interleukin 6 Homo sapiens 28-32 29616124-4 2018 Incubation with sodium citrate for 24 h revealed that the levels of interleukin-1beta (IL-1beta), IL-8 and tumor necrosis factor increased with an increasing of dose of sodium citrate, whereas the IL-6 levels exhibited only a slight alteration. Sodium Citrate 169-183 interleukin 6 Homo sapiens 197-201 34856207-12 2022 CPFX treatment (i) increased expression of CASP-3, CASP-9, and BCL2-L13, (ii) elevated the basal oxygen consumption rate, and (iii) lowered the mtDNA copy numbers and expression levels of TGF-B2, IL-6 and IL-1B compared to vehicle-control cells. Ciprofloxacin 0-4 interleukin 6 Homo sapiens 196-200 34155816-0 2021 Downregulation of miR-98-5p expression induces interleukin-6 expression in rheumatoid fibroblast-like synoviocytes. mir-98-5p 18-27 interleukin 6 Homo sapiens 47-60 29943522-10 2018 In gabapentin group, IL-6 levels at T1 and T2 were significantly lower in comparison to values measured in placebo group at the same time points. Gabapentin 3-13 interleukin 6 Homo sapiens 21-25 34438645-6 2021 Proteomics analysis of cytokines showed that niacin supplementation increased the expression of duodenal transforming growth factor-beta (TGF-beta), jejunal interleukin-10 (IL-10) and ileal interleukin-6 (IL-6) (p < 0.05), and reduced the expression of ileal interleukin-8 (IL-8) (p < 0.05) compared with the control diet. Niacin 45-51 interleukin 6 Homo sapiens 190-203 34438645-6 2021 Proteomics analysis of cytokines showed that niacin supplementation increased the expression of duodenal transforming growth factor-beta (TGF-beta), jejunal interleukin-10 (IL-10) and ileal interleukin-6 (IL-6) (p < 0.05), and reduced the expression of ileal interleukin-8 (IL-8) (p < 0.05) compared with the control diet. Niacin 45-51 interleukin 6 Homo sapiens 205-209 34221397-5 2021 According to studies, although few in number, the Tociluzimab (TCZ), which is an anti-IL6, could prevent or even suppress this storm, leading to a less severe clinical state of the disease and a faster recovery. tioconazole 63-66 interleukin 6 Homo sapiens 86-89 34939110-2 2022 The cytokines TNF-alpha, IL-1beta and IL-6 induce accumulation of degradation products of the amyloid precursor protein (APP) combined with heparan sulfate (HS) chains released from glypican-1 (Gpc-1) by NO-dependent cleavage. Heparitin Sulfate 140-155 interleukin 6 Homo sapiens 38-42 34877356-14 2021 IL-6 and TNF-alpha were expected to be potential prediction indexes of paraquat-induced ALI. Paraquat 71-79 interleukin 6 Homo sapiens 0-4 29943522-12 2018 CONCLUSIONS: Though preemptive oral gabapentin administration did not reduce postoperative pain and analgesic requirements in total knee arthroplasty surgery, it attenuated IL-6 production on the first postoperative day. Gabapentin 36-46 interleukin 6 Homo sapiens 173-177 29067681-13 2018 Furthermore, using real-time reverse transcription-polymerase chain reaction beta-actin, fibronectin, interleukin-6 and IL-1b genes were confirmed as targets upregulated by IL-1beta and downregulated by chitosan-triclosan particles. Chitosan 203-211 interleukin 6 Homo sapiens 102-115 34817126-1 2021 OBJECTIVES: To evaluate the serum and salivary levels of IL-1beta, IL-6, IL-17A, TNF-alpha, IL-4 and, IL-10 in patients with Oral Lichen Planus (OLP) treated with Photobiomodulation (PBM) and clobetasol propionate 0.05%. Clobetasol 192-213 interleukin 6 Homo sapiens 67-71 34080071-6 2021 While low baseline albumin and high bilirubin values were associated with high IL6, liver cirrhosis, alcoholic liver disease, and portal vein infiltration were associated with high IL8. Bilirubin 36-45 interleukin 6 Homo sapiens 79-82 34813629-9 2021 Ursodeoxycholate was previously reported to inhibit binding of SARS-CoV-2 to angiotensin-converting enzyme 2; suppress pro-inflammatory cytokines like TNF-alpha, IL-1beta, IL-2, IL-4, and IL-6; have antioxidant and anti-apoptotic effects; and increase alveolar fluid clearance in acute respiratory distress syndrome. Ursodeoxycholic Acid 0-16 interleukin 6 Homo sapiens 188-192 29412148-7 2018 Additionally, treatment of senescent astrocytes with NF-kappaB inhibitor, BAY 11-7092, also suppressed the secretion of IL-6 and IL-8, suggesting NF-kappaB was required for SASP. bay 11-7092 74-85 interleukin 6 Homo sapiens 120-124 34869555-9 2021 Results: Compared with the fasting group, the CHO group exhibited a decrease in interleukin 6 (IL-6) levels on days 1 and 7 (75.47 and 7.06 pg/mL, respectively), IL-8 levels on day 1 (274.61 pg/mL) and tumour necrosis factor (TNF) levels on days 1, 3, and 7 (11.16, 9.55, and 9.67 pg/mL, respectively). CAV protocol 46-49 interleukin 6 Homo sapiens 80-93 34869555-9 2021 Results: Compared with the fasting group, the CHO group exhibited a decrease in interleukin 6 (IL-6) levels on days 1 and 7 (75.47 and 7.06 pg/mL, respectively), IL-8 levels on day 1 (274.61 pg/mL) and tumour necrosis factor (TNF) levels on days 1, 3, and 7 (11.16, 9.55, and 9.67 pg/mL, respectively). CAV protocol 46-49 interleukin 6 Homo sapiens 95-99 34869555-11 2021 Compared with the placebo group, the CHO group exhibited a decrease in IL-6 levels on day 1 and TNF levels on day 3. CAV protocol 37-40 interleukin 6 Homo sapiens 71-75 34869555-13 2021 Conclusion: Preoperative CHO and drinking water are associated with decreased levels of IL-6, IL-8, and TNF. CAV protocol 25-28 interleukin 6 Homo sapiens 88-92 34063134-0 2021 Interleukin-6 and Interleukin-8 Regulate STAT3 Activation Migration/Invasion and EMT in Chrysophanol-Treated Oral Cancer Cell Lines. chrysophanic acid 88-100 interleukin 6 Homo sapiens 0-13 34063134-6 2021 However, the effect of chrysophanol on the production of IL-6 and IL-8 is unknown. chrysophanic acid 23-35 interleukin 6 Homo sapiens 57-61 34063134-9 2021 Our results showed that treatment with chrysophanol significantly decreased the expression of IL-6 and IL-8, as well as the invasion ability of oral cancer cells. chrysophanic acid 39-51 interleukin 6 Homo sapiens 94-98 34063134-11 2021 Mechanistically, chrysophanol inhibited IL-6- and IL-8-induced invasion and STAT3 phosphorylation. chrysophanic acid 17-29 interleukin 6 Homo sapiens 40-44 34867348-7 2021 We showed that LPS-induced expression of IL-6 and IL-1beta was cAMP dependent, that IL-6 and IL-1beta expression were induced by direct cAMP activation (forskolin) and that RG0216 and deprenyl effectively reduced cAMP-mediated cytokine expression. rg0216 173-179 interleukin 6 Homo sapiens 41-45 29324263-6 2018 RESULTS: IL-6 levels and MMP-9/TIMP-1 ratio were significantly higher in AF patients than in non-AF controls (P < .001), and in persistent than in paroxysmal AF (P < .001), in line with NT-proBNP and LA diameter. nt-probnp 192-201 interleukin 6 Homo sapiens 9-13 34867348-8 2021 Targeted protein kinase A (PKA) and Exchange Protein Activated by cAMP (EPAC) activation regulated IL-6 and IL-1beta expression, albeit in different ways, but both cytokines were effectively decreased with RG0216. rg0216 206-212 interleukin 6 Homo sapiens 99-103 34509368-3 2021 Results of enzyme-linked immunosorbent assay (ELISA) showed that WEKPPVSH significantly mitigated the secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) (P < 0.01). wekppvsh 65-73 interleukin 6 Homo sapiens 189-202 34509368-3 2021 Results of enzyme-linked immunosorbent assay (ELISA) showed that WEKPPVSH significantly mitigated the secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) (P < 0.01). wekppvsh 65-73 interleukin 6 Homo sapiens 204-208 35580727-3 2022 Pro-inflammatory cytokines (TNF, IL6, GMCSF and IL12p40) secretion levels were tested in the presence of bis-1,2,3-triazole compounds when the macrophages were activated with LPS. bis-1,2,3-triazole 105-123 interleukin 6 Homo sapiens 33-36 35413537-10 2022 AT7519 blocked cell cycle progression and induced apoptosis by inhibiting IL-6/STAT3 pathway. 4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide 0-6 interleukin 6 Homo sapiens 74-78 29353760-8 2018 CLL patients requiring fludarabine based chemotherapy expressed higher levels of IL-6 and IL-17, while CLL patients with the lowest levels of IgA/IgM had higher levels of IL-6, but not IL-17. fludarabine 23-34 interleukin 6 Homo sapiens 81-85 35413537-11 2022 Taken together, AT519 exhibits great anti-tumor effects in lung cancer, and the mechanism was related closely to IL-6/STAT3 signaling pathway, which suggests the important roles of STAT3 in CDKs inhibitors. at519 16-21 interleukin 6 Homo sapiens 113-117 35636449-8 2022 The present review suggests that TXA has an anti-inflammatory effect in patients undergoing orthopaedic surgery illustrated by decreased levels of C-reactive protein and interleukin-6 in patients receiving TXA compared with patients receiving no or lower doses of TXA. Tranexamic Acid 33-36 interleukin 6 Homo sapiens 170-183 35636449-8 2022 The present review suggests that TXA has an anti-inflammatory effect in patients undergoing orthopaedic surgery illustrated by decreased levels of C-reactive protein and interleukin-6 in patients receiving TXA compared with patients receiving no or lower doses of TXA. Tranexamic Acid 206-209 interleukin 6 Homo sapiens 170-183 34533029-3 2021 In our study, miR-10a-5p overexpression inhibited the proliferation, migration, and IL-6/IL-8 level of LX-2 and human liver cancer fibroblasts (HLCFs) cells. mir-10a-5p 14-24 interleukin 6 Homo sapiens 84-88 34687147-4 2022 In functional assays, pretreatment of EC with simvastatin to inhibit mevalonate metabolism resulted in a dose-dependent reduction in the costimulation of CD45RO+ CD4+ T cell proliferation as well as IL-2, IFNgamma and IL-6 production vs. vehicle-treated EC. Simvastatin 46-57 interleukin 6 Homo sapiens 218-222 29495330-1 2018 (1) Background: Carotenoids may be inversely associated with inflammatory markers (i.e., TNF-alpha, IL-6, IL-1beta). Carotenoids 16-27 interleukin 6 Homo sapiens 100-104 34725544-10 2021 The results demonstrated that overexpression of miR-139-5p effectively repressed HG-activated inflammation, as indicated by the upregulation of inflammation cytokines, including TNF-alpha, IL-6, and Cox-2, in ARPE-19 cells. mir-139-5p 48-58 interleukin 6 Homo sapiens 189-193 34771451-7 2021 Cytokine profiling in patients who developed CRS after APVO436 infusion indicates that the predominant cytokine in this inflammatory cytokine response was IL-6. apvo436 55-62 interleukin 6 Homo sapiens 155-159 35574720-8 2022 Kaempferol down-regulated the mRNA expression levels of TNF-alpha, IL-6, and CCL2 in oxaliplatin-treated astrocytes. kaempferol 0-10 interleukin 6 Homo sapiens 67-71 35551580-13 2022 IL-6 level was significantly correlated with OSDI (R = 0.18, P = 0.020) and TBUT (R = 0.20, P = 0.019). tbut 76-80 interleukin 6 Homo sapiens 0-4 29115448-12 2018 In conclusion, BDCM suppresses the expression of TNF-alpha, IL-8, and IL-6 by inhibiting the NF-kappaB and mitogen activated protein kinase signaling pathways. bromodichloromethane 15-19 interleukin 6 Homo sapiens 70-74 35628136-0 2022 Novel Benzoxazoles Containing 4-Amino-Butanamide Moiety Inhibited LPS-Induced Inflammation by Modulating IL-6 or IL-1beta mRNA Expression. 4-aminobutanamide 30-48 interleukin 6 Homo sapiens 105-109 34684771-12 2021 Attenuation of S1-induced transcription of IL-6 and IL-1beta by the MAPK kinase inhibitor U0126 was greater than that by the Akt inhibitor perifosine, and the effects were potentiated by simultaneous treatment with both inhibitors. perifosine 139-149 interleukin 6 Homo sapiens 43-47 28992224-13 2018 As a complementary finding, treatment with HCO and MCO in vitro dialysates induced a pro-inflammatory response of the cells as demonstrated by elevated messenger RNA expression of tumour necrosis factor alpha and interleukin-6, as well as upregulation of ACE and decreased levels of ACE2. hco 43-46 interleukin 6 Homo sapiens 213-226 34435647-7 2021 CT treatment also reduced the increase in the mRNA levels of IL-6, IL-1beta and TNF-alpha induced by CoCl2. cobaltous chloride 101-106 interleukin 6 Homo sapiens 61-65 35525835-12 2022 CONCLUSIONS: PMX-DHP combined with steroid pulse therapy might reduce GRO, IL-10, IL-1Ra, IL-5, IL-6, and MCP-1 levels in ARF, contributing to better oxygenation in the disorder. 1,4-dihydropyridine 17-20 interleukin 6 Homo sapiens 96-100 28643937-7 2017 RESULTS: S100A9 and S100A8/A9 significantly upregulated IL-6 and IL-8 expression, which was inhibited upon treatment with the TLR4 inhibitor TAK242. ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate 141-147 interleukin 6 Homo sapiens 56-60 35414285-6 2022 In the presence of lipopolysaccharide (LPS)-stimulated macrophages, empty EDLs and EDLs incorporating diclofenac were able to reduce the levels of important pro-inflammatory cytokines, namely interleukin-6 (IL-6; 85% and 77%, respectively) and tumor necrosis factor-alpha (TNF-alpha; 64% and 72%, respectively). Diclofenac 102-112 interleukin 6 Homo sapiens 192-205 35414285-6 2022 In the presence of lipopolysaccharide (LPS)-stimulated macrophages, empty EDLs and EDLs incorporating diclofenac were able to reduce the levels of important pro-inflammatory cytokines, namely interleukin-6 (IL-6; 85% and 77%, respectively) and tumor necrosis factor-alpha (TNF-alpha; 64% and 72%, respectively). Diclofenac 102-112 interleukin 6 Homo sapiens 207-211 35432570-10 2022 The molecular docking results showed effective ingredients (quercetin, kaempferol, and 7-methoxy-2-methyl isoflavone) have good docking results with targets (IL-6, PTGS2, and TNF). kaempferol 71-81 interleukin 6 Homo sapiens 158-162 34567413-7 2021 Olaparib reduced the inflammation score, the concentration of IL-1beta and IL-6, enhanced the level of IL-10, and decreased the intestinal permeability in TNBS-colitis. olaparib 0-8 interleukin 6 Homo sapiens 75-79 34568366-5 2021 Results: IL-6, IL-8, IP-10, and MCP-1 in aqueous humor of DME vitrectomized eyes were significantly higher than in non-vitrectomized DME eyes, while VEGF was lower than in non-vitrectomized DME eyes. dme 58-61 interleukin 6 Homo sapiens 9-13 29162939-0 2017 Intravesicular administration of sodium hyaluronate ameliorates the inflammation and cell proliferation of cystitis cystica et glandularis involving interleukin-6/JAK2/Stat3 signaling pathway. Hyaluronic Acid 33-51 interleukin 6 Homo sapiens 149-162 34294366-4 2021 Moreover, hucMSC-Exo significantly down-regulated the levels of inflammatory cytokines IL-6, IL-1beta, and TNF-alpha in APAP-treated livers. Acetaminophen 120-124 interleukin 6 Homo sapiens 87-91 35365594-14 2022 Following the intervention, the serum levels of the inflammatory markers (hsCRP, IL-6, and TNF-alpha) were significantly lower in the MK-7 group (p < 0.05), but not in the placebo group. vitamin MK 7 134-138 interleukin 6 Homo sapiens 81-85 35212163-3 2022 We initially found that the glycolytic inhibitor 2-deoxy-d-glucose (2-DG), a simple monosaccharide, attenuated cellular responses to IL-6 by inhibiting N-linked glycosylation of the IL-6 receptor gp130. Monosaccharides 84-98 interleukin 6 Homo sapiens 182-186 28842514-10 2017 The poly(I:C)-induced release of inflammatory mediators, including CXCL8, interleukin (IL)-6 and CXCL1, from ASMCs from cough patients was significantly impaired compared with healthy non-cough subjects. Iodine 9-10 interleukin 6 Homo sapiens 74-92 35399859-9 2022 After treatment, the inflammatory factor levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and high-sensitivity C-reactive protein (hs-CRP) in the diclofenac sodium group were observably higher compared with the celecoxib group (P < 0.05), and the inflammatory factor levels in the celecoxib group were remarkably higher compared with the iguratimod group (P < 0.05). Diclofenac 170-187 interleukin 6 Homo sapiens 51-64 35399859-9 2022 After treatment, the inflammatory factor levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and high-sensitivity C-reactive protein (hs-CRP) in the diclofenac sodium group were observably higher compared with the celecoxib group (P < 0.05), and the inflammatory factor levels in the celecoxib group were remarkably higher compared with the iguratimod group (P < 0.05). Diclofenac 170-187 interleukin 6 Homo sapiens 66-70 35104780-0 2022 The DPA-derivative 11S, 17S-dihydroxy 7,9,13,15,19 (Z,E,Z,E,Z)-docosapentaenoic acid inhibits IL-6 production by inhibiting ROS production and ERK/NF-kappaB pathway in keratinocytes HaCaT stimulated with a fine dust PM10. (z,e,z,e,z)-docosapentaenoic acid 51-84 interleukin 6 Homo sapiens 94-98 34472736-8 2021 IL-6 plasma concentrations increased significantly compared with baseline at S3 in lidocaine group, and at S2 and S3 in control group. Lidocaine 83-92 interleukin 6 Homo sapiens 0-4 34472736-13 2021 CONCLUSION: Adjunctive lidocaine-based scalp block and laryngotracheal local anesthesia might attenuate CSF IL-6 concentration increase in patients with brain aneurysm. Lidocaine 23-32 interleukin 6 Homo sapiens 108-112 34275451-10 2021 Kaempferol-treatment could induce higher levels of IL-1beta, IL-4, IL-6, TNF-alpha and IFN-gamma in the serum at 3 dpi which were then declined to normal levels at 5 dpi. kaempferol 0-10 interleukin 6 Homo sapiens 67-71 34162132-7 2021 Our results show that safinamide inhibited the expression of pro-inflammatory cytokines such as IL-1alpha, TNF-alpha, and IL-6. safinamide 22-32 interleukin 6 Homo sapiens 122-126 29201182-0 2017 The efficacy of gastrodin in combination with folate and vitamin B12 on patients with epilepsy after stroke and its effect on HMGB-1, IL-2 and IL-6 serum levels. gastrodin 16-25 interleukin 6 Homo sapiens 143-147 34304366-7 2021 Asprosin was observed to have a positive correlation with HbA1c, FBG, TC, LDL-C, IL-6, and TNF-alpha in the T2DM group. asprosin 0-8 interleukin 6 Homo sapiens 81-85 34304366-8 2021 In the patients with T2DM + NP, asprosin was found to be positively correlated with BMI, HbA1c, insulin, HOMA-IR, Cr, UAE, IL-6, and TNF-alpha, and it was inversely correlated with eGFR. asprosin 32-40 interleukin 6 Homo sapiens 123-127 34110682-3 2021 Here, an intelligent aptameric dual channel graphene-TWEEN 80 field effect transistor (DGTFET) biosensing device for on-site detection of IFN-gamma, TNF-alpha, and IL-6 within 7 min with limits of detection (LODs) of 476 x 10-15 , 608 x 10-15 , or 611 x 10-15 m respectively in biofluids is presented. Polysorbates 53-61 interleukin 6 Homo sapiens 164-168 35281240-11 2022 The RMPP group had higher neutrophil ratio (N%), C-reactive protein (CRP), interleukin-6 (IL-6), lactic dehydrogenase (LDH), and D-dimer than the GMPP group (P < 0.05). rmpp 4-8 interleukin 6 Homo sapiens 75-88 35281240-11 2022 The RMPP group had higher neutrophil ratio (N%), C-reactive protein (CRP), interleukin-6 (IL-6), lactic dehydrogenase (LDH), and D-dimer than the GMPP group (P < 0.05). rmpp 4-8 interleukin 6 Homo sapiens 90-94 35204307-8 2022 The expression of pro-inflammatory cytokines, including interleukin (IL)-1beta, IL-6, and IL-8, was also suppressed by 3,5,7-trimethoxyflavone (6). 3,5,7-Trimethoxyflavone 119-142 interleukin 6 Homo sapiens 80-84 35222804-7 2022 Intriguingly, the toxic effect of Cr(VI) upon premature senescence of L02 hepatocytes and increased levels of IL-6/FGF23 could be partially reversed by the intracellular Ca2+ chelator BAPTA-AM pretreatment. 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 184-192 interleukin 6 Homo sapiens 110-114 29201182-1 2017 This study evaluated the efficacy of gastrodin in combination with folate (FOL) and vitamin-B12 (V-B12) on patients with epilepsy after stroke (EAS) and its effect on high-mobility group protein B1 (HMGB-1), interleukin-1 (IL-1), and IL-6 serum levels. gastrodin 37-46 interleukin 6 Homo sapiens 234-238 34258288-3 2021 Results: Adenosine-5"-N-ethyluronamide (NECA), a stable adenosine analogue, significantly stimulate inflammatory mediator (IL-6) (p < 0.001) and nuclear receptors (NR4A) (p < 0.05) and significantly modulate metabolic (PFK, LCAD, PGC-1alpha, and CPT1B) gene expressions in skeletal muscle cells (p < 0.05, p < 0.05, p < 0.001, and p < 0.01, respectively). Adenosine-5'-(N-ethylcarboxamide) 40-44 interleukin 6 Homo sapiens 123-127 29048735-7 2017 In addition, real-time polymerase chain reaction and enzyme-linked immunosorbent assay results indicated that 6-OHDA elevated the production of proinflammatory cytokines, such as interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha. Oxidopamine 110-116 interleukin 6 Homo sapiens 198-244 34074349-1 2021 OBJECTIVE: To estimate the relationship between serum TNFalpha, IL-6, and serum CZP levels and the clinical response to CZP in RA patients in the TSUBAME study. Certolizumab Pegol 120-123 interleukin 6 Homo sapiens 64-68 34074349-4 2021 Serum TNFalpha and IL-6 levels significantly decreased from baseline at 24 h after the first administration of CZP. Certolizumab Pegol 111-114 interleukin 6 Homo sapiens 19-23 35273734-9 2022 The PPV+IVC group also showed lower serum levels of TNF-alpha, IL-6, and IL-1beta than the PPV group. DOP protocol 4-7 interleukin 6 Homo sapiens 63-67 35237157-9 2022 In the experiment with macrophages, XBS markedly suppressed the (Lipopolysaccharides) LPS-induced expression of NF-kappaB p65 and the production of pro-inflammatory cytokines IL-6 and IL-1beta, supporting XBS to achieve an anti-inflammatory effect through regulating NF-kappaB p65. CHEMBL4082603 36-39 interleukin 6 Homo sapiens 175-179 34063891-6 2021 PEG-BA inhibited the production of IL-6 by 4-5.5 fold compared to BA-treated cells. peg-ba 0-6 interleukin 6 Homo sapiens 35-39 28975891-18 2017 This corresponds to our findings of highly increased IL6 expression primarily in the peritumoral skin and to previous literature describing CAF-induced tumor-promoting IL6 expression upon UV-exposure in cutaneous SCC. cafestol palmitate 140-143 interleukin 6 Homo sapiens 168-171 34068523-7 2021 NTS and MSM also inhibited LPS-induced nuclear accumulation and binding of NF-kappaB to proinflammatory cytokines COX-2, IL-1beta, and IL-6. nts 0-3 interleukin 6 Homo sapiens 135-139 35094658-7 2022 IL-1beta-induced high secretion levels of nitric oxide and prostaglandin 2, TNF-alpha, IL-6 and MCP-1 were down-regulated by TB-II treatment, indicating an anti-inflammatory effect of TB-II on OA in vitro condition. timosaponin B-II 125-130 interleukin 6 Homo sapiens 87-91 35094658-7 2022 IL-1beta-induced high secretion levels of nitric oxide and prostaglandin 2, TNF-alpha, IL-6 and MCP-1 were down-regulated by TB-II treatment, indicating an anti-inflammatory effect of TB-II on OA in vitro condition. timosaponin B-II 184-189 interleukin 6 Homo sapiens 87-91 28481867-6 2017 The mechanism whereby RB inactivation increases IL-6 production in MCF-7 cells appeared to involve fatty acid oxidation (FAO)-dependent mitochondrial metabolism and c-Jun NH(2)-terminal kinase (JNK). fao 121-124 interleukin 6 Homo sapiens 48-52 35045875-1 2022 The suite of marked anemia benefits that momelotinib has consistently conferred on myelofibrosis (MF) patients stem from its unique inhibitory activity on the BMP6/ACVR1/SMAD and IL-6/JAK/STAT3 pathways, resulting in decreased hepcidin (master iron regulator) expression, higher serum iron and hemoglobin levels, and restored erythropoiesis. N-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide 41-52 interleukin 6 Homo sapiens 179-183 34064310-11 2021 In the peritoneal fluid, Hidrox treatment reduced interleukin (IL)-1beta, IL2, IL6, tumor necrosis factor-alpha (TNF-alpha) and vascular endothelial grow factor (VEGF) levels increased by the disease. hidrox 25-31 interleukin 6 Homo sapiens 80-83 35366469-13 2022 The binding of five active ingredients originated from Gancao-Banxia to IL-6-STAT3 was verified by molecular docking, namely quercetin, coniferin, licochalcone a, Licoagrocarpin and (3S,6S)-3-(benzyl)-6-(4-hydroxybenzyl)piperazine-2,5-quinone, maximizing therapeutic efficacy. LICOAGROCARPIN 163-177 interleukin 6 Homo sapiens 72-76 35366469-13 2022 The binding of five active ingredients originated from Gancao-Banxia to IL-6-STAT3 was verified by molecular docking, namely quercetin, coniferin, licochalcone a, Licoagrocarpin and (3S,6S)-3-(benzyl)-6-(4-hydroxybenzyl)piperazine-2,5-quinone, maximizing therapeutic efficacy. (3s,6s)-3-(benzyl)-6-(4-hydroxybenzyl)piperazine-2,5-quinone 182-242 interleukin 6 Homo sapiens 72-76 35636449-8 2022 The present review suggests that TXA has an anti-inflammatory effect in patients undergoing orthopaedic surgery illustrated by decreased levels of C-reactive protein and interleukin-6 in patients receiving TXA compared with patients receiving no or lower doses of TXA. Tranexamic Acid 264-267 interleukin 6 Homo sapiens 170-183 35446183-14 2022 Increased IL-6 and IL-10 secretion by SB431542 along with increase in pSTAT3 and pCREB1 could probably explain these TGF-beta/Smad3 independent effects. 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide 38-46 interleukin 6 Homo sapiens 10-14 34990470-10 2022 However, only IL-6 substantially attenuated the association of MR-proADM with all-cause mortality. mr-proadm 63-72 interleukin 6 Homo sapiens 14-18 34990470-13 2022 Future studies should investigate the role of IL-6 and further characteristics of subclinical inflammation in the association between MR-proADM and all-cause mortality. mr-proadm 134-143 interleukin 6 Homo sapiens 46-50 28524237-11 2017 In vitro dialysis of cytokine-enriched plasma samples with MCO and HCO membranes reduces IL-6 levels. hco 67-70 interleukin 6 Homo sapiens 89-93 28738247-11 2017 Furthermore, GW9662, a PPAR-gamma inhibitor, attenuated the inhibitory effect of asiatic acid on PGE2, NO, IL-6, and IL-8 production. 2-chloro-5-nitrobenzanilide 13-19 interleukin 6 Homo sapiens 107-111 35552024-5 2022 Mechanically, tumor cells treated by OVM secrete IL-6 to activate the PI3K-gamma/AKT axis in TAMCs, thus promoting the infiltration of TAMCs and aggravating their inhibition on cytotoxic CD8+ T lymphocytes. tamcs 93-98 interleukin 6 Homo sapiens 49-53 35552024-5 2022 Mechanically, tumor cells treated by OVM secrete IL-6 to activate the PI3K-gamma/AKT axis in TAMCs, thus promoting the infiltration of TAMCs and aggravating their inhibition on cytotoxic CD8+ T lymphocytes. tamcs 135-140 interleukin 6 Homo sapiens 49-53 28829242-6 2017 We found that BA treatment led to remarkable reductions of OA-related proinflammatory gene expressions, including interleukin (IL)-6, tumor necrosis factor (TNF), chemokine (C-X-C motif) ligand 1 (CXCL1), and CXCL10. baicalin 14-16 interleukin 6 Homo sapiens 114-132 35599774-4 2022 The PPI network analysis revealed that the backbone of the highly connective CFAS-D network comprises NFKB1, CTNNB1, ALB, peroxides, NOS2, tumor necrosis factor (TNF), and interleukin-6 (IL-6) and that the network comprises interconnected immune-oxidative-nitrosative and Wnt/beta-catenin subnetworks. Peroxides 122-131 interleukin 6 Homo sapiens 187-191 28883755-4 2017 Treatment with cobalt chloride (CoCl2) and hydrogen peroxide (H2O2) significantly increased the expression levels of IL-6, IL-8, and IP-10 in a dose-dependent manner in CRT-MG and U251-MG astroglioma cells, but not in microglia cells. cobaltous chloride 15-30 interleukin 6 Homo sapiens 117-121 35118691-3 2022 Compared with 2"-FL or KLDS 8001 alone, 2"-FL+KLDS 8001 significantly reduced lipopolysaccharide (LPS)-induced malondialdehyde (MDA), lactate dehydrogenase (LDH) release, and cytokine (IL-1beta, IL-6, and TNF-alpha) production. 2'-fucosyllactose 14-19 interleukin 6 Homo sapiens 195-199 28883755-4 2017 Treatment with cobalt chloride (CoCl2) and hydrogen peroxide (H2O2) significantly increased the expression levels of IL-6, IL-8, and IP-10 in a dose-dependent manner in CRT-MG and U251-MG astroglioma cells, but not in microglia cells. cobaltous chloride 32-37 interleukin 6 Homo sapiens 117-121 28786993-6 2017 Following uric acid administration, there was an accentuated increase in IL-6 during the oral lipid tolerance test (P<0.001). Uric Acid 10-19 interleukin 6 Homo sapiens 73-77 35497015-0 2022 In silico screening for oligopeptides useful as capture and reporting probes for interleukin-6 biosensing. Oligopeptides 24-37 interleukin 6 Homo sapiens 81-94 28786993-9 2017 In health individuals, acute increase in uric acid results in an increased IL-6 response when challenged with lipid load. Uric Acid 41-50 interleukin 6 Homo sapiens 75-79 28244246-6 2017 Interestingly, in lipopolysaccharide (LPS)-stimulated macrophages, CoCl2 modified the M1-type activation profile by increasing iNOS expression and nitric oxide production and decreasing NOX2 and IL-6. cobaltous chloride 67-72 interleukin 6 Homo sapiens 195-199 35573706-8 2022 Overall, our study indicates that HA-enriched ECM generated by co-cultures of activated CD4 T cells with FLS from human joints creates a pathogenic microenvironment by promoting adhesion of leukocytes and expression of inflammatory cytokines including IL6. Hyaluronic Acid 34-36 interleukin 6 Homo sapiens 252-255 35456686-7 2022 Furthermore, the produced RSV-PCL microparticles reduced the expression of inflammatory (IL-6, IL-8, COX-2) and proteolytic (MMP-2, MMP-9) mediators. rsv-pcl 26-33 interleukin 6 Homo sapiens 89-93 28244246-9 2017 In addition, CoCl2 was found to remodel the classical M1 phenotype of macrophage activation by changing the balance of iNOS, NOX2 and IL-6. cobaltous chloride 13-18 interleukin 6 Homo sapiens 134-138 28390266-8 2017 Patients with suboptimal serum 25-OHD had higher IL-6, 8 and 18 (p=0.003, 0.010 and 0.002 respectively) and lower levels of IL-11 (p=0.005). 25-ohd 31-37 interleukin 6 Homo sapiens 49-53 35100519-6 2022 Protein-protein interaction analysis of the differentially expressed transcripts regulated by DMB showed 5 hub genes with a strong connectivity of proinflammatory cytokines and chemokines including Kng1, Cxcl1, Cxcl2, CxcL6 and Il6. 3,3-dimethylbutan-1-ol 94-97 interleukin 6 Homo sapiens 228-231 35363433-3 2022 In human keratinocytes, arsenite increased the levels of m6 A methylation by upregulating the RNA methyltransferase like 3 (METTL3), mediating the disordered secretion of indicators that reflect inflammatory homeostasis (IL-6, IL-17, and IL-10). arsenite 24-32 interleukin 6 Homo sapiens 221-225 30090537-5 2017 The mRNA levels of IL-6, IL-8, TNF-alpha and IL-1beta were upregulated by SiO2 NP or cold exposure, and more so in the combined group. sio2 np 74-81 interleukin 6 Homo sapiens 19-23 35101812-4 2022 The balance between omega-3 and omega-6 levels in the cell membrane has a critical role in regulating the equilibrium between proinflammatory and antiinflammatory processes and inducing IL-6 production. omega-6 32-39 interleukin 6 Homo sapiens 186-190 30090537-6 2017 The expressions of the proinflammatory cytokine genes IL-6, IL-8, TNF-alpha and IL-1beta increased highly significantly (P < 0.01) in the SiO2 NP alone group and the combined group, compared with the control. sio2 np 141-148 interleukin 6 Homo sapiens 54-58 28460169-1 2017 This work demonstrates a highly sensitive peroxide test strip (PTS)-based enzyme-linked immunosorbent assay (ELISA) for both qualitative and quantitative detection of drugs of abuse (morphine) and disease biomarkers (interleukin-6 and HIV-1 capsid antigen p24). Peroxides 42-50 interleukin 6 Homo sapiens 217-230 35131633-10 2022 RESULTS: VX-765 reduced IIRI-induced oxidative stress and inflammatory response both in vivo and in vitro, while it decreased the levels of TNF-alpha, IL-6, IL-1beta as well as the modified Park/Chiu scores. belnacasan 9-15 interleukin 6 Homo sapiens 151-155 27682001-6 2017 PFOA enhanced gene expression of several pro-inflammatory cytokines, including tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8 by the activation of nuclear factor (NF)-kappaB in IgE-stimulated mast cells. perfluorooctanoic acid 0-4 interleukin 6 Homo sapiens 138-142 35360193-6 2022 The mRNA levels of interleukin 6 and tumor necrosis factor-alpha were significantly decreased in the sperm of patients after treatment with vitamin C compared to before treatment. Ascorbic Acid 140-149 interleukin 6 Homo sapiens 19-64 28473058-7 2017 Positive associations between the intakes of margaric acid, butter, total dairy, or whole grain and IL-6 production were observed (P<.05). margaric acid 45-58 interleukin 6 Homo sapiens 100-104 35327498-5 2022 Serum bilirubin levels are positively correlated with the levels of the antioxidative enzymes as superoxide dismutase, catalase, and glutathione peroxidase, while it is inversely correlated with C-reactive protein, TNF-alpha, interleukin (IL)-2, IL-6, and IL-10 release in diabetic kidney disease. Bilirubin 6-15 interleukin 6 Homo sapiens 246-250 32454590-7 2017 Results: Adenosine-5"-N-ethyluronamide (NECA), a stable adenosine analogue, concentration- and time-dependently stimulates IL-6 gene expression in skeletal muscle cells. Adenosine-5'-(N-ethylcarboxamide) 40-44 interleukin 6 Homo sapiens 123-127 35592139-9 2022 Meanwhile, Ag-Hes@H significantly reduced the expression of inflammatory cytokines, including IL-6, MMP9 and TNF-alpha. ag-hes 11-17 interleukin 6 Homo sapiens 94-98 35165269-4 2022 In this study, we found that interleukin-6 (IL-6) was significantly increased after exposure to NVP-BEZ235, and we proposed a treatment in which an anti-IL-6 antibody was combined with NVP-BEZ235 for HCC. dactolisib 100-106 interleukin 6 Homo sapiens 29-42 27655254-7 2017 LPS-induced upregulation of IL-1alpha/beta, IL-6 and TNF-alpha was also diminished by the TGR5-ligands allopregnanolone and taurolithocholic acid in mono-cultured microglia. Taurolithocholic Acid 124-145 interleukin 6 Homo sapiens 44-48 35165269-4 2022 In this study, we found that interleukin-6 (IL-6) was significantly increased after exposure to NVP-BEZ235, and we proposed a treatment in which an anti-IL-6 antibody was combined with NVP-BEZ235 for HCC. dactolisib 100-106 interleukin 6 Homo sapiens 44-48 28048971-14 2017 The levels of HOMA2-IR in patients with POCD were significantly higher than those of patients without POCD at 6h and 7days after operation (P<0.05).The levels of serum IL-6 and TNF- alpha were positively correlated with HOMA2-IR value at 6h after operation (RIL-6=0.426, P<0.01; RTNF-a=0.381, P<0.01). pocd 40-44 interleukin 6 Homo sapiens 171-175 35524377-7 2022 Our findings exhibited a significant reduction of TNF-alpha, IL-6, and MYD88 gene expressions after treatment with three doses of M2000 and an optimum dose of diclofenac. Diclofenac 159-169 interleukin 6 Homo sapiens 61-65 27082319-0 2017 Harpagoside suppresses IL-6 expression in primary human osteoarthritis chondrocytes. harpagoside 0-11 interleukin 6 Homo sapiens 23-27 27082319-3 2017 Here we used an in vitro model of inflammation in OA to investigate the potential of harpagoside to suppress the production of inflammatory cytokines/chemokines such as IL-6 and matrix degrading proteases. harpagoside 85-96 interleukin 6 Homo sapiens 169-173 27082319-13 2017 Expression of IL-6 was highly induced by IL-1beta, which was significantly inhibited by pre-treatment of OA chondrocytes with harpagoside. harpagoside 126-137 interleukin 6 Homo sapiens 14-18 28033682-10 2017 Ropi-HP-beta-CD increased twofold the IL-6 release by HGF in comparison with the control, while 100 mum ropi-MLV led to an increased release of all pro-inflammatory cytokines by HGF. ropi-hp-beta-cd 0-15 interleukin 6 Homo sapiens 38-42 27742487-3 2017 The cytokine profile of the supernatant of CPCs that were treated with the mineralocorticoid showed an induction of interleukin-6 secretion. cpcs 43-47 interleukin 6 Homo sapiens 116-129 27903982-8 2017 In addition, the potent PKC inhibitor bisindolylmaleimide I could prevent M2-induced IL-6 upregulation and further inhibited glioma VM facilitation. bisindolylmaleimide I 38-59 interleukin 6 Homo sapiens 85-89 29250545-10 2017 Simvastatin significantly reduced the levels of cTnT, CK-MB, TNF-alpha, IL-6, and IL-8 (P < 0.05), reduced the expression of LC3-II/LC3-I and Beclin 1, and increased the expression of phosphorylation of AMPK. Simvastatin 0-11 interleukin 6 Homo sapiens 72-76 27634203-9 2017 Cytokine analysis showed a rapid decline in interleukin-6 with momelotinib treatment, and a slower reduction in other inflammatory cytokines. N-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide 63-74 interleukin 6 Homo sapiens 44-57 26911385-11 2017 Free donepezil and donepezil loaded nanoparticle administration caused a significant dose-dependent decrease in both gene and protein expression levels of IL-1beta, IL-6, GM-CSF and TNF-alpha. Donepezil 5-14 interleukin 6 Homo sapiens 165-169 26911385-11 2017 Free donepezil and donepezil loaded nanoparticle administration caused a significant dose-dependent decrease in both gene and protein expression levels of IL-1beta, IL-6, GM-CSF and TNF-alpha. Donepezil 19-28 interleukin 6 Homo sapiens 165-169 27329245-7 2017 In a study of SASP markers, the expressions of IL6 and IL8 were also more upregulated in human non-pathological prostatic glands after ADT than in untreated specimens. adt 135-138 interleukin 6 Homo sapiens 47-50 27329245-8 2017 IL6, IL8, and MMP2 were expressed more strongly in human prostate cancer specimens resected after ADT than in untreated tumors. adt 98-101 interleukin 6 Homo sapiens 0-3 28326930-9 2017 JWH015 reduced the concentration of major pro-inflammatory factors (IL-6 and MCP-1) and increased the concentration of a major anti-inflammatory factor (TGF-beta) in lipopolysaccharide-stimulated cells. JHW 015 0-6 interleukin 6 Homo sapiens 68-72 27588816-8 2016 However, when combining IL-1ss, IL-6 and G-CSF in the patients with CD, the cytokine levels were significantly lower in the AndoSanTM - versus the placebo group, visit 3. andosantm 124-133 interleukin 6 Homo sapiens 32-36 27835611-4 2016 We also studied the role of TLR4 in Co2+-mediated adhesion molecule expression in MonoMac 6 macrophages.We show that Co2+ increases secretion of inflammatory cytokines, including IL-6 and IL-8, in HMEC-1. Cobalt(2+) 117-121 interleukin 6 Homo sapiens 179-183 27833154-6 2016 We found the levels of cytokines, including nterleukin (IL)-6, IL-10, interferon gamma (IFN-gamma) in RMPP group were significantly higher than those in GMPP group (P < 0.01). rmpp 102-106 interleukin 6 Homo sapiens 44-61 27589413-9 2016 The treatment with diclofenac sodium, in the PTZ induced kindling model, decreased severity of seizures and interleukin-6 and TNF-alpha levels in the hippocampus of animals treated with doses of 5 and 10mg/kg. Diclofenac 19-36 interleukin 6 Homo sapiens 108-121 27589413-9 2016 The treatment with diclofenac sodium, in the PTZ induced kindling model, decreased severity of seizures and interleukin-6 and TNF-alpha levels in the hippocampus of animals treated with doses of 5 and 10mg/kg. Pentylenetetrazole 45-48 interleukin 6 Homo sapiens 108-121 26841003-9 2016 Plasma IL-6 concentration increased 20-min post-exercise when compared to pre in both the Cho (p = .002) and nCho (p = .009), but remained elevated at the 2-h time point in the nCho trial (p = .03). CAV protocol 90-93 interleukin 6 Homo sapiens 7-11 27631497-6 2016 Production of IL-6 and TNF-alpha after costimulation with TSH and CD40L was greater than that after TSH or CD40L stimulation alone. Thyrotropin 58-61 interleukin 6 Homo sapiens 14-18 27631497-6 2016 Production of IL-6 and TNF-alpha after costimulation with TSH and CD40L was greater than that after TSH or CD40L stimulation alone. Thyrotropin 100-103 interleukin 6 Homo sapiens 14-18 27626938-4 2016 A subset of the pathway regulators, including interleukin-6, and JNK, were found to be linearly correlated with cell viability, and may function as molecular determinants of cytotoxic responses of BEAS-2B cells to nickel exposures. Nickel 214-220 interleukin 6 Homo sapiens 46-59 27337297-9 2016 Cocaine-mediated-increased upregulation of GFAP correlated with increased expression of proinflammatory mediators such as TNF, IL1B, and IL6. Cocaine 0-7 interleukin 6 Homo sapiens 137-140 27086089-11 2016 Plasma concentrations of IL-6, IL-8, and TNFalpha, and peritoneal concentrations of IL-6 and IL-8, were significantly lower in the simvastatin group postoperatively. Simvastatin 131-142 interleukin 6 Homo sapiens 25-29 27086089-11 2016 Plasma concentrations of IL-6, IL-8, and TNFalpha, and peritoneal concentrations of IL-6 and IL-8, were significantly lower in the simvastatin group postoperatively. Simvastatin 131-142 interleukin 6 Homo sapiens 84-88 27224660-7 2016 Our results showed that ginsenoside Rf significantly reduced the production of IL-1beta, IL-6, TNF-alpha, NO, and ROS, which are most highly activated in IBD. ginsenoside Rf 24-38 interleukin 6 Homo sapiens 89-93 27112637-1 2016 This randomized within-subject, double blind study aimed to compare the effects of a single dose of two different antipsychotics (haloperidol and aripiprazole) on cortisol, interleukin (IL)-6 and hippocampal regional Cerebral Blood Flow (rCBF) in the same 17 healthy male individuals. Haloperidol 130-141 interleukin 6 Homo sapiens 173-191 27112637-1 2016 This randomized within-subject, double blind study aimed to compare the effects of a single dose of two different antipsychotics (haloperidol and aripiprazole) on cortisol, interleukin (IL)-6 and hippocampal regional Cerebral Blood Flow (rCBF) in the same 17 healthy male individuals. Aripiprazole 146-158 interleukin 6 Homo sapiens 173-191 27112637-5 2016 Interleukin-6 levels were also lower following haloperidol (F(2,22)=4.19, p=0.048) in comparison with placebo (p=0.02; CI=0.14, 1.8), but not with aripiprazole. Haloperidol 47-58 interleukin 6 Homo sapiens 0-13 27112637-5 2016 Interleukin-6 levels were also lower following haloperidol (F(2,22)=4.19, p=0.048) in comparison with placebo (p=0.02; CI=0.14, 1.8), but not with aripiprazole. Aripiprazole 147-159 interleukin 6 Homo sapiens 0-13 27112637-9 2016 Finally, our data suggest that the increased hippocampal rCBF is a manifestation of the reduction in IL-6 and cortisol which follows the administration of haloperidol. Haloperidol 155-166 interleukin 6 Homo sapiens 101-105 26104857-0 2016 Synergistic augmentation of ATP-induced interleukin-6 production by arsenite in HaCaT cells. arsenite 68-76 interleukin 6 Homo sapiens 40-53 27028995-7 2016 Ex vivo studies showed that salidroside has no toxicity to cells, and inhibits the production of PGE2, phosphorylation of p38 or JNKs, and secretion of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) caused by SUV irradiation. rhodioloside 28-39 interleukin 6 Homo sapiens 152-165 27028995-7 2016 Ex vivo studies showed that salidroside has no toxicity to cells, and inhibits the production of PGE2, phosphorylation of p38 or JNKs, and secretion of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) caused by SUV irradiation. rhodioloside 28-39 interleukin 6 Homo sapiens 167-171 26972254-10 2016 In addition, cornuside decreased phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated production and secretion of pro-inflammatory cytokines such as TNF-alpha and IL-6 in human mast cells. Calcimycin 93-99 interleukin 6 Homo sapiens 188-192 25649144-7 2016 RESULTS: The production of interleukin (IL)-1beta and IL-6 was higher in patients compared with controls and this correlated with serum urate levels. Uric Acid 136-141 interleukin 6 Homo sapiens 54-58 26973208-4 2016 RESULTS: Increased immune mediator concentrations were observed in the sera of the asbestos-exposed workers compared to controls for human fibroblast growth factor (FGF-b), vascular endothelial growth factor (VEGF), CCL5 (RANTES), CXCL10 (IP-10), CLEC11A (SCGF-b), CCL27 (CTACK), CCL11 (EOTAXIN), IL-5 and IL-6 (p<0.001). Asbestos 83-91 interleukin 6 Homo sapiens 306-310 26603372-7 2016 Consistent with the in vivo findings, oxygen-glucose deprivation (OGD) significantly reduced TLR3 and IL-6 mRNA expression in microglia, but poly-ICLC significantly rescued TLR3 and IL-6 expression. oxygen-glucose 38-52 interleukin 6 Homo sapiens 102-106 26603372-13 2016 Also, oxygen-glucose deprivation (OGD) reduces TLR3 and IL-6 expression in microglia, but polyinosinic polycytidylic acid (poly-ICLC) rescues TLR3 and IL-6. oxygen-glucose 6-20 interleukin 6 Homo sapiens 56-60 26869439-6 2016 LPS-activated HKCCs, but not hepatocyte monocultures, treated with trovafloxacin or acetaminophen, compounds associated with immune-mediated hepatotoxicity, showed LPS-dependent decreases in interleukin-6 production with concomitant increases in Cyp3A activity. Acetaminophen 84-97 interleukin 6 Homo sapiens 191-204 26982743-10 2016 Both the B2 receptor antagonist MEN16132 and TLR-2 silencing inhibited IL-6 and IL-8 secretion in human OA synoviocytes. (4-amino-5-(4-(4-(2,4-dichloro-3-(2,4-dimethyl-8-quinolyloxymethyl)phenylsulfonamido)tetrahydro-2H-4-pyranoylcarbonyl)piperazino)-5-oxopentyl)(trimethyl)ammonium 32-40 interleukin 6 Homo sapiens 71-75 26679059-0 2016 Cocaine abuse and effects in the serum levels of cytokines IL-6 and IL-10. Cocaine 0-7 interleukin 6 Homo sapiens 59-63 26679059-2 2016 The aim of this study was to investigate serum levels of pro and antiinflammatory cytokines, IL-6 and IL-10 respectively, in cocaine users from a young population-based sample. Cocaine 125-132 interleukin 6 Homo sapiens 93-97 26679059-6 2016 RESULTS: There was a statistically significant increase in IL-6 (p=0.037) and decrease in IL-10 (p=0.007) serum levels, between cocaine users and the control group. Cocaine 128-135 interleukin 6 Homo sapiens 59-63 26679059-7 2016 There was also an increase in the ratio IL-6/IL-10 (p=0.013) among cocaine users individuals, when compared to the control group. Cocaine 67-74 interleukin 6 Homo sapiens 40-44 26163998-6 2015 There were significant correlations in PAH group between IL-6 levels and uric acid, parameters of ventilatory efficiency in cardiopulmonary exercise testing: VE/VO2, VE/VCO2, VE/VCO2 slope and peak PetCO2. Uric Acid 73-82 interleukin 6 Homo sapiens 57-61 26559850-10 2015 RESULTS: Simvastatin (5 mg/kg/day) improved clinical outcome, induced an increase in TGF-beta mRNA expression and inhibited IL-6, IL-12p40, IL-12p70, RANTES and MIP-1beta secretion (p < 0.05). Simvastatin 9-20 interleukin 6 Homo sapiens 124-128 25715004-7 2015 The latanoprost-induced release of IL-6, IL-8, and MCP-1 was attenuated by inhibitors of MAPK (PD98059, SB203580, or JNK inhibitor II) or NF-kappaB (IkappaB kinase 2 inhibitor) signaling pathways. Latanoprost 4-15 interleukin 6 Homo sapiens 35-39 25994389-11 2015 IL-6 circulating levels were associated with both very-low-density lipoprotein and lipid hydroperoxide levels. Lipid Peroxides 83-102 interleukin 6 Homo sapiens 0-4 26291279-3 2015 Significant increases were seen in the release of IL-6, MCP-1/CCL2, RANTES/CCL5 and KC/CXCL1 and this release was inhibited by treatment with Brefeldin A, suggesting a golgi-mediated release of cytokines by muscle cells. Brefeldin A 142-153 interleukin 6 Homo sapiens 50-54 26529046-12 2015 Stimulation of primary human RPE cells with Bz-ATP increased VEGFA and IL6 mRNA levels, which were abrogated by 3TC. CHEMBL339386 44-50 interleukin 6 Homo sapiens 71-74 26104917-9 2015 The CaN inhibitor FK506 reduced these IL-6 neuroprotective properties. Tacrolimus 18-23 interleukin 6 Homo sapiens 38-42 26317519-6 2015 Few statistically significant associations or clear trends were observed, although in full models mono-carboxypropyl phthalate (MCPP) was significantly (percent change with interquartile range increase in exposure [%Delta] = 8.89, 95% confidence interval [CI] = 3.28, 14.8), and mono-benzyl phthalate (MBzP) was suggestively (%Delta = 6.79, 95%CI = -1.21, 15.4) associated with IL-6. mono-carboxypropyl phthalate 98-126 interleukin 6 Homo sapiens 378-382 26072064-9 2015 PPAR-gamma antagonist, GW9662, significantly attenuated protective effect on ICAM-1, IL-6 and PPAR-gamma expression by pioglitazone, eplerenone and their combined treatment. 2-chloro-5-nitrobenzanilide 23-29 interleukin 6 Homo sapiens 85-89 26020489-3 2015 This study aimed to investigate the IL-6 susceptibility of melanoma cells from different stages in the presence of simvastatin to overcome loss of growth arrest. Simvastatin 115-126 interleukin 6 Homo sapiens 36-40 26020489-9 2015 Although WM35 cells are highly resistant to simvastatin-induced apoptosis, coadministration with IL-6 enhanced the susceptibility to undergo apoptosis. Simvastatin 44-55 interleukin 6 Homo sapiens 97-101 26020489-11 2015 Furthermore, the IL-6 receptor blocking antibody tocilizumab was coadministered and unmasked an IL-6-sensitive proportion in the simvastatin-induced caspase 3 activity of metastatic melanoma cells. Simvastatin 129-140 interleukin 6 Homo sapiens 17-21 26020489-11 2015 Furthermore, the IL-6 receptor blocking antibody tocilizumab was coadministered and unmasked an IL-6-sensitive proportion in the simvastatin-induced caspase 3 activity of metastatic melanoma cells. Simvastatin 129-140 interleukin 6 Homo sapiens 96-100 25704622-8 2015 Pre-treatment with simvastatin (S-L) reduced IL-6 (P = 0.02), TNF-alpha (P = 0.02), and MMP-9 (P = 0.01); post-treatment (L-S) reduced IL-1beta (P = 0.02) and TNF-alpha (P = 0.04), while simultaneous treatment (L+S) did not reduce any of the cytokines tested. Simvastatin 19-30 interleukin 6 Homo sapiens 45-49 26170625-11 2015 CONCLUSION: Vitamin C (500 mg twice daily) has potential effects in alleviating inflammatory status by reducing hs-CRP, IL-6, and FBG in hypertensive and/or diabetic obese patients. Ascorbic Acid 12-21 interleukin 6 Homo sapiens 120-124 25882540-4 2015 Confirmatory enzyme-linked immunosorbent assays (ELISAs) showed that PGF2alpha stimulated increased output of interleukin (IL) 1beta, IL6, IL8 (CXCL8) and monocyte chemotactic protein-1 (MCP1, also known as chemokine (c-c motif) ligand 2, CCL2) by HUSMCs isolated from both upper and lower uterine segments. Dinoprost 69-78 interleukin 6 Homo sapiens 134-137 25882540-10 2015 Inhibition of ERK reversed PGF2alpha-induced IL1beta, IL6 and CCL2 output, while inhibition of PI3K blocked the effect of PGF2alpha on IL6, CXCL8 and CCL2 output and inhibition of NF-kappaB reversed PGF2alpha-induced IL1beta and CCL2 output. Dinoprost 27-36 interleukin 6 Homo sapiens 54-57 25882540-10 2015 Inhibition of ERK reversed PGF2alpha-induced IL1beta, IL6 and CCL2 output, while inhibition of PI3K blocked the effect of PGF2alpha on IL6, CXCL8 and CCL2 output and inhibition of NF-kappaB reversed PGF2alpha-induced IL1beta and CCL2 output. Dinoprost 122-131 interleukin 6 Homo sapiens 135-138 25882540-10 2015 Inhibition of ERK reversed PGF2alpha-induced IL1beta, IL6 and CCL2 output, while inhibition of PI3K blocked the effect of PGF2alpha on IL6, CXCL8 and CCL2 output and inhibition of NF-kappaB reversed PGF2alpha-induced IL1beta and CCL2 output. Dinoprost 122-131 interleukin 6 Homo sapiens 135-138 26198966-9 2015 CONCLUSION: Intravenous injection of small-dose lidocaine and ketamine during the operation can reduce the incidence of POCD in elderly patients undergoing surgeries for gastrointestinal tumors possibly in relation to decreased serum S-100beta, NSE and IL-6 levels. Lidocaine 48-57 interleukin 6 Homo sapiens 253-257 25510525-2 2015 We conducted two studies to examine (1) whether serum 25-hydroxyvitamin D (25OHD) and/or intramuscular VDR protein concentrations are associated with intramuscular interleukin-6 (IL-6) and/or tumor necrosis factor-alpha (TNFalpha); and (2) whether 16-week supplementation with vitamin D3 alters intramuscular IL-6 and/or TNFalpha. 25-hydroxyvitamin D 54-73 interleukin 6 Homo sapiens 164-177 25510525-2 2015 We conducted two studies to examine (1) whether serum 25-hydroxyvitamin D (25OHD) and/or intramuscular VDR protein concentrations are associated with intramuscular interleukin-6 (IL-6) and/or tumor necrosis factor-alpha (TNFalpha); and (2) whether 16-week supplementation with vitamin D3 alters intramuscular IL-6 and/or TNFalpha. 25-hydroxyvitamin D 54-73 interleukin 6 Homo sapiens 179-183 26028838-0 2015 A prospective study to assess the levels of interleukin-6 following administration of diclofenac, ketorolac and tramadol after surgical removal of lower third molars. Diclofenac 86-96 interleukin 6 Homo sapiens 44-57 26028838-7 2015 AIM: To evaluate the changes in serum IL-6 levels following surgical removal of third molars under local anaesthesia after administration of two NSAIDs diclofenac and ketorolac and opioid tramadol post operatively. Diclofenac 152-162 interleukin 6 Homo sapiens 38-42 26028838-11 2015 RESULTS: The results of our study showed that all three drugs i.e. diclofenac, ketorolac and tramadol have properties which can downregulate the production of IL-6 in response to surgical trauma. Diclofenac 67-77 interleukin 6 Homo sapiens 159-163 26028838-12 2015 CONCLUSION: It is of clinical significance that the suppression of IL-6 values occurs in tramadol group closely following the diclofenac group. Diclofenac 126-136 interleukin 6 Homo sapiens 67-71 26521440-6 2015 Kaempferol significantly decreased the release of histamine, IL-6, IL-8, IL-1beta and TNF-alpha of activated HMC-1 mast cells (P<0.01). kaempferol 0-10 interleukin 6 Homo sapiens 61-65 25611805-5 2015 Phlorizin also decreased the expression of UVB-induced pro-inflammatory cytokines, such as interleukin-1 beta (IL-1beta), interleukin-6 (IL-6) and interleukin-8 (IL-8) at the mRNA level. Phlorhizin 0-9 interleukin 6 Homo sapiens 122-135 25611805-5 2015 Phlorizin also decreased the expression of UVB-induced pro-inflammatory cytokines, such as interleukin-1 beta (IL-1beta), interleukin-6 (IL-6) and interleukin-8 (IL-8) at the mRNA level. Phlorhizin 0-9 interleukin 6 Homo sapiens 137-141 25369272-0 2015 Modulation of TNF-alpha, TNF-alpha receptors and IL-6 after treatment with AM3 in professional cyclists. Immunoferon 75-78 interleukin 6 Homo sapiens 49-53 25511110-5 2015 Cobalt chloride treatment increased NF-kappaB expression, nitric oxide (NO) and iNOS expression, cytokines TNF-alpha and IL-6 as compared to hypoxia exposure. cobaltous chloride 0-15 interleukin 6 Homo sapiens 121-125 25511110-6 2015 Our study showed that CoCl2 stabilizes HIF-1alpha to create hypoxia like conditions but it mainly influences the inflammatory response via NF-kappaB signaling pathway by skewing the production of proinflammatory molecules like TNF-alpha, IL-6 and NO. cobaltous chloride 22-27 interleukin 6 Homo sapiens 238-242 25866715-17 2015 Simvastatin clearly lowers the serum levels of CRP and IL-6, and the white blood cell count in dialysis patients. Simvastatin 0-11 interleukin 6 Homo sapiens 55-59 25379992-6 2015 Procyanidin B2 mediated inhibition of inflammasome activation includes the inactivation of the NF-kappaB signalling pathway, the first stage required for the transcription of inflammasome precursors, through the inhibition of p65 nuclear expression and DNA binding, resulting in the transcriptional repression of target genes, such as COX2 , iNOS and production of IL-6 and NO. procyanidin B2 0-14 interleukin 6 Homo sapiens 365-369 25461290-2 2015 We find that high TiO2 concentrations induce the cytokines Interleukin IL-1beta, IL-6, and IL-10 secretion, while at low concentrations only IL-6 secretion is observed. titanium dioxide 18-22 interleukin 6 Homo sapiens 81-85 25461290-5 2015 Our results indicate that concentration of corona covered TiO2 particles below 1 mug/ml induce IL-6 secretion which is reported to be responsible for the development of autoimmune diseases as well as for the secretion of acute phase proteins. titanium dioxide 58-62 interleukin 6 Homo sapiens 95-99 25652866-11 2015 In POCD group, serum IL-6, IL-17, MCP3 and MPIF-1 levels at 4 hours postoperatively were higher when compared with ones at 1 day preoperatively. pocd 3-7 interleukin 6 Homo sapiens 21-25 26457493-24 2015 When the variables of subjects with upper quartile of TSH were compared with lower quartile of TSH, we found significantly higher BMI, waist circumference, WHR, increased concentration of IL-6, cholesterol, triglycerides, and T-Abs, and concentrations of cHDL and fT4 were lower. Thyrotropin 54-57 interleukin 6 Homo sapiens 188-192 26539255-6 2015 RESULTS: UA significantly increased the expressions of IL-6, ICAM-1, TNF-alpha, and MCP-1 and the production of ROS in HUVEC. Uric Acid 9-11 interleukin 6 Homo sapiens 55-59 25331710-8 2014 Furthermore, a significant difference in IL-1beta (P<= 0.007) and IL-6 (P<= 0.02) concentrations was observed in patients with severe 25-hydroxyvitamin D deficiency compared with patients with 25-hydroxyvitamin D concentration >= 25 nmol/l, and this difference was remarkable for TNF-alpha. 25-hydroxyvitamin D 140-159 interleukin 6 Homo sapiens 69-73 25342742-13 2014 We conclude that glioma-derived miR-92a induces IL-6(+) IL-10(+) NKT cells; this fraction of NKT cells can suppress cytotoxic CD8(+) T cells. mir-92a 32-39 interleukin 6 Homo sapiens 48-52 25365225-4 2014 CYT387 treatment inhibited activation of both NF-kappaB and STAT and disrupted expression of the protumorigenic cytokines CCL5 and IL-6 in these IKBKE-driven breast cancer cells. N-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide 0-6 interleukin 6 Homo sapiens 131-135 25519876-10 2014 Moreover, we found significant positive correlation between 25-hydroxyvitamin D and each of well-know sepsis markers, C-reactive protein, tumor necrosis factor-alpha and interleukin-6. 25-hydroxyvitamin D 60-79 interleukin 6 Homo sapiens 170-183 25240148-6 2014 Terbutaline suppressed T cell proliferation and IL-6 production and increased AOE activities involving ERK, PKA, PKC, and NF-kappaB pathways and NO production. Terbutaline 0-11 interleukin 6 Homo sapiens 48-52 25240148-8 2014 E2 in the presence of terbutaline reversed terbutaline-induced effects on T cell proliferation, IL-6 production, p-ERK and p-CREB expression, AOE activities, NO production, and NF-kappaB expression. Terbutaline 22-33 interleukin 6 Homo sapiens 96-100 25240148-8 2014 E2 in the presence of terbutaline reversed terbutaline-induced effects on T cell proliferation, IL-6 production, p-ERK and p-CREB expression, AOE activities, NO production, and NF-kappaB expression. Terbutaline 43-54 interleukin 6 Homo sapiens 96-100 25522414-6 2014 RESULTS: We found that venlafaxine and EPA were anti-inflammatory: venlafaxine decreased IL-6, with a trend for decreases of IL-8 and IP-10, while EPA decreased the levels of IL-6, IL-15, IL-1RA, and IP-10. Eicosapentaenoic Acid 39-42 interleukin 6 Homo sapiens 89-93 25522414-6 2014 RESULTS: We found that venlafaxine and EPA were anti-inflammatory: venlafaxine decreased IL-6, with a trend for decreases of IL-8 and IP-10, while EPA decreased the levels of IL-6, IL-15, IL-1RA, and IP-10. Eicosapentaenoic Acid 39-42 interleukin 6 Homo sapiens 175-179 25218635-3 2014 Simplexin, a daphnane diterpene ester, was identified for the first time from this genus and caused an increase in the production of cytokines (IFNgamma, IL1beta, IL6, and IL13) by peripheral blood mononuclear cells. simplexin 0-9 interleukin 6 Homo sapiens 163-166 25338584-5 2014 The level of VEGF and IL-6 in culture supernatants of RPMI8226/DOX was higher than that in RPMI 8226. rpmi8226 54-62 interleukin 6 Homo sapiens 22-26 25257410-5 2014 Simvastatin therapy significantly reduced the levels of C-reactive protein and IL-6. Simvastatin 0-11 interleukin 6 Homo sapiens 79-83 24374727-4 2014 We used a multiplex protein assay to determine the tumor expression levels of the proangiogenic proteins IL-6, IL-8, bFGF, PDGF-BB and VEGF-A in formalin-fixed paraffin-embedded tumors from the MAX clinical trial patients with available tissue samples. Formaldehyde 145-153 interleukin 6 Homo sapiens 105-109 24788303-6 2014 The expression of important pro-inflammatory cytokines (tumor necrosis factor-alpha, interleukin-6 and interferon-gamma), which was quantified using ELISA showed that simvastatin decreased the expression of pro-inflammatory cytokines to an average of 2-fold. Simvastatin 167-178 interleukin 6 Homo sapiens 85-98 24801497-7 2014 Nevertheless, Fha44 induced the secretion of IL-12p40, IL-12p70, IL-23 and IL-6 by MDDC, albeit at lower levels than FHA. mddc 83-87 interleukin 6 Homo sapiens 75-79 24661543-4 2014 Our second objective was to investigate whether TSH induces other cytokines besides IL-6. Thyrotropin 48-51 interleukin 6 Homo sapiens 84-88 24493202-8 2014 Fetuin-A upregulated IL-6 and IL-8, and this was potentiated by palmitate and blocked by CLI-095. ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate 89-96 interleukin 6 Homo sapiens 21-25 24549402-9 2014 Serum IL-35, IL-6 and IL-17 levels were positively correlated with total bilirubin and international normalized ratio, and negatively correlated with albumin. Bilirubin 73-82 interleukin 6 Homo sapiens 13-17 24714343-0 2014 Paraquat-induced reactive oxygen species inhibit neutrophil apoptosis via a p38 MAPK/NF-kappaB-IL-6/TNF-alpha positive-feedback circuit. Paraquat 0-8 interleukin 6 Homo sapiens 95-99 23483320-0 2014 Effect of perioperative parecoxib on postoperative pain and local inflammation factors PGE2 and IL-6 for total knee arthroplasty: a randomized, double-blind, placebo-controlled study. parecoxib 24-33 interleukin 6 Homo sapiens 96-100 23483320-1 2014 To assess the efficacy of postoperative pain management and the concentration change of PGE-2 and IL-6 of joint fluid with parecoxib after postoperative total knee arthroplasty. parecoxib 123-132 interleukin 6 Homo sapiens 98-102 23483320-7 2014 The present study demonstrated that the perioperative administration of parecoxib after primary TKA resulted in significantly improved postoperative analgesic management as defined by reduction in opioid requirement, lower pain scores and ROM, and significantly lowered local inflammation factors PGE2 and IL-6. parecoxib 72-81 interleukin 6 Homo sapiens 306-310 24292270-7 2014 Five hundred nanometers and 1,000 nm CPS particles stimulated IL-6 and IL-8 secretion in monocytes and macrophages, chemotaxis towards a chemotactic stimulus of monocytes and phagocytosis of bacteria by macrophages and provoked an oxidative burst of granulocytes. cps 37-40 interleukin 6 Homo sapiens 62-66 24269928-7 2014 The combination of olodaterol plus tiotropium further reduced IL-6 and IL-8 release. olodaterol 19-29 interleukin 6 Homo sapiens 62-66 24090796-9 2014 While viewing the disgusting images, cocaine-dependent individuals exhibited aberrant skin conductivity and increased the secretion of the salivary cytokine interleukin-6 relative to control participants. Cocaine 37-44 interleukin 6 Homo sapiens 157-170 24128422-2 2014 We investigated the effect of lipopolysacharide (LPS) and progesterone (P4) upon expression of TLR-4/MyD88, TNFalpha, IL-6, IL-8, IL-10, and HBD2 on the human amniotic epithelium. lipopolysacharide 30-47 interleukin 6 Homo sapiens 118-122 25253919-11 2014 Vitamin C inhibited LPS-induced ROS, DNA damage, TNF-alpha, IL-6, and p38 in macrophages cells. Ascorbic Acid 0-9 interleukin 6 Homo sapiens 60-64 24140851-8 2013 The higher heating value (HHV) and oxygen content of HSF from humin were fully compatible with biofuel characteristics. 5-[(Pyridin-3-Ylmethyl)amino]-1h-Pyrazole-4-Carboxamide 26-29 interleukin 6 Homo sapiens 53-56 24382441-13 2013 It was found that most significant addition markers of tumor progression with presence of DTC in BM are the levels of cytokines such as TNF in BM and PB, CSF-1 and IL-6 in PB and endogenous IFN in BM and PB of BC patients. dtc 90-93 interleukin 6 Homo sapiens 164-168 24095958-3 2013 Herein, we identify the naturally occurring sesquiterpene lactone cynaropicrin as a potent inhibitor of both IL-6-inducible and constitutive STAT3 activation (IC50=12 muM). cynaropicrin 66-78 interleukin 6 Homo sapiens 109-113 24004609-0 2013 Arsenite evokes IL-6 secretion, autocrine regulation of STAT3 signaling, and miR-21 expression, processes involved in the EMT and malignant transformation of human bronchial epithelial cells. arsenite 0-8 interleukin 6 Homo sapiens 16-20 24004609-2 2013 The present results showed that, evoked by arsenite, secretion of interleukin-6 (IL-6), a pro-inflammatory cytokine, led to the activation of STAT3, a transcription activator, and to increased levels of a microRNA, miR-21. arsenite 43-51 interleukin 6 Homo sapiens 66-79 24004609-2 2013 The present results showed that, evoked by arsenite, secretion of interleukin-6 (IL-6), a pro-inflammatory cytokine, led to the activation of STAT3, a transcription activator, and to increased levels of a microRNA, miR-21. arsenite 43-51 interleukin 6 Homo sapiens 81-85 24004609-4 2013 For human bronchial epithelial cells, cultured in the presence of anti-IL-6 antibody for 3days, the arsenite-induced EMT and malignant transformation were reversed. arsenite 100-108 interleukin 6 Homo sapiens 71-75 24004609-5 2013 Thus, IL-6, acting on STAT3 signaling, which up-regulates miR-21in an autocrine manner, contributes to the EMT induced by arsenite. arsenite 122-130 interleukin 6 Homo sapiens 6-10 24236147-9 2013 In meta-regression analyses, a significant positive association was found between the SMD and the preoperative interleukin-6 peripheral blood concentration in patients with POCD (Coef.= 0.0587, p-value=0.038, 5 studies). pocd 173-177 interleukin 6 Homo sapiens 111-124 23897063-5 2013 Depletion of HIV-specific CD8(+) IL-10(+) cells from PBMCs led to upregulation of CD38 on CD14(+) monocytes together with increased IL-6 production, in response to gag stimulation. Glycosaminoglycans 164-167 interleukin 6 Homo sapiens 132-136 23921144-8 2013 To further elucidate the regulatory mechanism whereby PA amplifies LPS signal, our studies showed that PA and LPS synergistically increased hydrolysis of sphingomyelin by stimulating acid sphingomyelinase (ASMase) activity, which contributed to a marked increase in ceramide production and IL-6 upregulation. Sphingomyelins 154-167 interleukin 6 Homo sapiens 290-294 23991193-0 2013 Novel single nucleotide polymorphisms in interleukin 6 affect tacrolimus metabolism in liver transplant patients. Tacrolimus 62-72 interleukin 6 Homo sapiens 41-54 23991193-6 2013 We speculated that IL6 rs1800796 polymorphisms may lead to individual differences in tacrolimus metabolism by affecting CYP3A enzymes levels and liver function after liver transplantation. Tacrolimus 85-95 interleukin 6 Homo sapiens 19-22 23991193-11 2013 Donor CYP3A5 rs776746 allele A, IL6 rs1800796 allele C, and recipient CYP3A5 rs776746 allele A were associated with fast tacrolimus metabolism. Tacrolimus 121-131 interleukin 6 Homo sapiens 32-35 23991193-14 2013 CONCLUSIONS: Combined analysis of donor CYP3A5 rs776746, IL6 rs1800796, and recipient CYP3A5 rs776746 polymorphisms may distinguish tacrolimus metabolism better than CYP3A5 rs776746 alone. Tacrolimus 132-142 interleukin 6 Homo sapiens 57-60 23991193-15 2013 IL6 may lead to individual differences in tacrolimus metabolism mainly by affecting liver function. Tacrolimus 42-52 interleukin 6 Homo sapiens 0-3 23977237-6 2013 Furthermore, ATROSAB inhibited release of IL-6 and IL-8 from HeLa and HT1080 cells, respectively, induced by TNF or lymphotoxin alpha (LTalpha). atrosab 13-20 interleukin 6 Homo sapiens 42-46 23619565-6 2013 Further studies revealed that PL suppressed the production of tumor necrosis factor-alpha (TNF-alpha) or Interleukin (IL)-6 and activation of nuclear factor-kappaB (NF-kappaB) or extracellular regulated kinases (ERK) 1/2 by LPS. piperlonguminine 30-32 interleukin 6 Homo sapiens 105-123 24036412-8 2013 The increasing secretion of IL-1beta, IL-6 and TNF-alpha induced by LPS could also be attenuated by the fosinoprilat treatment. fosinoprilat 104-116 interleukin 6 Homo sapiens 38-42 23874068-1 2013 UNLABELLED: The present study aimed to assess the effect of supplementation of omega-3 and/or vitamin C on serum interleukin-6 and high sensitivity C-reactive protein concentration and depression scores among shift workers in Shahid Tondgoyan oil refinery. Ascorbic Acid 94-103 interleukin 6 Homo sapiens 113-126 23494327-5 2013 RESULTS: Our data revealed that CITE inhibited the production of IL-6, PGD2, LTC4, and beta-hex induced by PMA plus A23187 (P<0.05). Calcimycin 116-122 interleukin 6 Homo sapiens 65-69 23361365-10 2013 Taken together, our results demonstrate that DHA and EPA are able to reduce IL-6-induced CRP expression in HepG2 cells via an inhibition of STAT3 activation. Eicosapentaenoic Acid 53-56 interleukin 6 Homo sapiens 76-80 23488692-9 2013 Furthermore, NS-398 reduced the production of IL-6 and IL-8, thus indicating that IL-1beta/HMGB1 complexes modulate cytokine production in part through prostanoid synthesis. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 13-19 interleukin 6 Homo sapiens 46-50 23631691-12 2013 HP enhanced production of TNF-alpha, IL-1beta, and IL-6 in PBMCs following CL097-stimulation more than LP and LP-der, whereas LP enhanced the secretion of TNF-alpha and IL-1beta in poly(I:C)- and CL097-stimulated PAMs. CL097 75-80 interleukin 6 Homo sapiens 51-55 23299933-7 2013 As predicted, the increase in QUIN was associated with higher levels of CSF interleukin-6. Quinolinic Acid 30-34 interleukin 6 Homo sapiens 76-89 23411072-1 2013 A series of novel 6-(aminomethylphenoxy)benzoxaborole analogs was synthesized for the investigation of the structure-activity relationship of the inhibition of TNF-alpha, IL-1beta, and IL-6, from lipopolysaccharide stimulated peripheral blood mononuclear cells. 6-(aminomethylphenoxy)benzoxaborole 18-53 interleukin 6 Homo sapiens 185-189 23238646-9 2013 Regarding inflammation, no TNFalpha was produced, and lidocaine decreased the levels of IL-6 and MCP-1 in a dose-dependent manner. Lidocaine 54-63 interleukin 6 Homo sapiens 88-92 23013513-0 2013 Effects of simvastatin and ezetimibe on interleukin-6 and high-sensitivity C-reactive protein. Simvastatin 11-22 interleukin 6 Homo sapiens 40-53 23013513-7 2013 Median changes (interquartile range) in IL-6 and hsCRP concentrations were -22% (-43 to 0%) and -30% (-44 to +19%) after simvastatin, -5% (-36 to +30%) and +9% (-22 to +107%) after ezetimibe, and +15% (-15 to +86%) and +1 (-30 to +49%) after the combination. Simvastatin 121-132 interleukin 6 Homo sapiens 40-44 23013513-9 2013 CONCLUSIONS: Simvastatin decreases the pro-inflammatory markers IL-6 and almost significantly hsCRP while ezetimibe monotherapy or the combination with simvastatin has no effect. Simvastatin 13-24 interleukin 6 Homo sapiens 64-68 23152113-8 2013 THG213.29 increased mRNA expression of heme-oxygenase 1, Bcl2, and FGF-2 in renal cortex; correspondingly, in EP(4)-transfected HEK293 cells, THG213.29 augmented FGF-2 and abrogated EP(4)-dependent overexpression of inflammatory IL-6 and of apoptotic death domain-associated protein and BCL2-associated agonist of cell death. thg213 0-6 interleukin 6 Homo sapiens 229-233 23744413-4 2013 Numerous studies report that treatment with clozapine (doses 37.5-600 mg) or olanzapine (doses 10-25 mg) or the use of these drugs in polytherapy cause pyrexia between 37.8-40.6 C. Additionally, levels of proinflammatory interleukins such as IL-6, IL-1,TNF-alpha were increased. Olanzapine 77-87 interleukin 6 Homo sapiens 243-247 23062767-12 2012 CONCLUSIONS: A high simvastatin dose or the combination of a low-dose simvastatin with ezetimibe reduce to a similar extent TLR2, TLR4 membrane expression and LPS-induced IL-6 and IL-1beta production in monocytes of hypercholesterolemic patients. Simvastatin 20-31 interleukin 6 Homo sapiens 171-175 23062767-12 2012 CONCLUSIONS: A high simvastatin dose or the combination of a low-dose simvastatin with ezetimibe reduce to a similar extent TLR2, TLR4 membrane expression and LPS-induced IL-6 and IL-1beta production in monocytes of hypercholesterolemic patients. Simvastatin 70-81 interleukin 6 Homo sapiens 171-175 23042198-13 2012 Notably, treatment with simvastatin abolished this CLP-evoked increase in HMBG1 and IL-6 levels in the plasma, suggesting that simvastatin is a potent inhibitor of systemic inflammation in sepsis. Simvastatin 24-35 interleukin 6 Homo sapiens 84-88 23042198-13 2012 Notably, treatment with simvastatin abolished this CLP-evoked increase in HMBG1 and IL-6 levels in the plasma, suggesting that simvastatin is a potent inhibitor of systemic inflammation in sepsis. Simvastatin 127-138 interleukin 6 Homo sapiens 84-88 22927445-7 2012 The pan-PKC inhibitor Go6850 and the PKCepsilon inhibitor Ro-31-8220 abrogated the augmenting effect of IL-32alpha on IL-6 production, whereas the classical PKC inhibitor Go6976 and the PKCdelta inhibitor rottlerin did not. bisindolylmaleimide I 22-28 interleukin 6 Homo sapiens 118-122 22475653-10 2012 CONCLUSIONS: Prostate cancer patients treated with ADT who carry variant alleles of the IL6 and TNFA genes are susceptible to heightened fatigue. adt 51-54 interleukin 6 Homo sapiens 88-91 22820625-6 2012 A positive correlation of MMPs with TIMPs in TB, MMP-1 and -9 with IL-6 in TB PF and MMP-9 with IFN-gamma in NTB PF was observed. tb pf 75-80 interleukin 6 Homo sapiens 67-71 22572621-11 2012 Intercellular adhesion molecule 1, vascular cell adhesion molecule 1, E-Selectin, Interleukin 6, and TNF-alpha were significantly increased in ECs treated with n-6 FAs. Fatty Acids, Omega-6 160-167 interleukin 6 Homo sapiens 82-95 23351502-9 2012 Levels of IL-6 and IL-10 decreased significantly (p = 0.025 and p = 0.047, respectively) in the paracetamol group at 24 hours but this was not of statistical significance in control group. Acetaminophen 96-107 interleukin 6 Homo sapiens 10-14 23060925-9 2012 Treg and IL-6 levels decreased following GEM monochemotherapy, IL-17A levels decreased after GEMOX, and IL-6 levels were reduced subsequent to BEV+CAPE+RT treatment. N-[(2z)-1,3-Thiazolidin-2-Ylidene]sulfamide 143-146 interleukin 6 Homo sapiens 104-108 21889886-8 2012 Higher AA intake (a proinflammatory omega-6 fatty acid) was related to higher IL-6 (OR=1.96; P=.034) and CRP (OR=1.95; P=.039) concentrations. Fatty Acids, Omega-6 36-54 interleukin 6 Homo sapiens 78-82 22493042-7 2012 PQ at 10 muM stimulated production of inflammatory and profibrogenic factors (tumor necrosis factor alpha, interleukin 6, and transforming growth factor beta1) and induced the transformation of normal human lung fibroblasts (WI38-VA13) to myofibroblasts; both effects were inhibited by Res. Paraquat 0-2 interleukin 6 Homo sapiens 107-120 22808498-8 2012 Orthodontic structures made from chromium-cobalt, or chromium-nickel alloys in the oral cavity of these patients increased the levels of MMP-2, IL-1beta and IL-6 in oral fluid. Nickel 62-68 interleukin 6 Homo sapiens 157-161 21879351-7 2012 The results of this study may imply that progressive decline in partial CO(2) pressure (hypocapnia) that develops during prolonged exercise may contribute to increased interleukin-6 production. co(2) 72-77 interleukin 6 Homo sapiens 168-181 22226662-9 2012 Also, changes in plasma total carotenoid and lycopene concentration were inversely correlated with the changes in IL-6 production in LPS-activated PBMCs. Carotenoids 30-40 interleukin 6 Homo sapiens 114-118 22205356-6 2012 We found that 25-hydroxyvitamin D levels were positively associated with 1,25-dihydroxyvitamin D, the relationship being greatest in advanced disease (significant interaction), and inversely related to those of inflammatory markers C-reactive protein and IL-6. 25-hydroxyvitamin D 14-33 interleukin 6 Homo sapiens 255-259 22293775-5 2012 gamma-tocotrienol effectively improved the TNF-alpha-induced adverse changes in MCP-1, IL-6 and adiponectin secretion, and in MCP-1, IL-6, adiponectin and PPARgamma mRNA expression. plastochromanol 8 0-17 interleukin 6 Homo sapiens 87-91 22293775-5 2012 gamma-tocotrienol effectively improved the TNF-alpha-induced adverse changes in MCP-1, IL-6 and adiponectin secretion, and in MCP-1, IL-6, adiponectin and PPARgamma mRNA expression. plastochromanol 8 0-17 interleukin 6 Homo sapiens 133-137 22452847-4 2012 In the present study, the relevance of the PKA activity and two PKA-activating drugs, aminophylline and adrenaline, to LPS-induced inflammatory cytokines (IL-6 and IL-8) and PGE2 by HGFs were examined. Aminophylline 86-99 interleukin 6 Homo sapiens 155-159 22192353-10 2012 Ciglitazone induced IL-6 messenger RNA expression, an effect that was suppressed by GW9662 pretreatment. 2-chloro-5-nitrobenzanilide 84-90 interleukin 6 Homo sapiens 20-24 22207723-0 2012 Role of vitamin C and E supplementation on IL-6 in response to training. Ascorbic Acid 8-17 interleukin 6 Homo sapiens 43-47 22207723-1 2012 Vitamin C and E supplementation has been shown to attenuate the acute exercise-induced increase in plasma interleukin-6 (IL-6) concentration. Ascorbic Acid 0-9 interleukin 6 Homo sapiens 106-119 22207723-1 2012 Vitamin C and E supplementation has been shown to attenuate the acute exercise-induced increase in plasma interleukin-6 (IL-6) concentration. Ascorbic Acid 0-9 interleukin 6 Homo sapiens 121-125 22207723-11 2012 In conclusion, our results indicate that, although vitamin C and E supplementation may attenuate exercise-induced increases in plasma IL-6 there is no clear additive effect when combined with endurance training. Ascorbic Acid 51-60 interleukin 6 Homo sapiens 134-138 21868713-8 2012 The HN2-induced activation of (44/42)MAPK and the up-regulation of IL-6 secretion in NHBECs were also largely reversed by a transforming growth factor-alpha (TGF-alpha)-blocking antibody and by the metalloprotease inhibitor GM 6001, suggesting that the HN2-related effects on EGFR signaling were TGF-alpha-dependent. N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide 224-231 interleukin 6 Homo sapiens 67-71 22119708-5 2012 All PFCs suppressed LPS-induced TNF-alpha production in hPBL and THP-1 cells, while IL-6 production was suppressed by PFOSA, PFOS, PFDA and fluorotelomer. perfluorooctane sulfonic acid 118-123 interleukin 6 Homo sapiens 84-88 22119708-5 2012 All PFCs suppressed LPS-induced TNF-alpha production in hPBL and THP-1 cells, while IL-6 production was suppressed by PFOSA, PFOS, PFDA and fluorotelomer. perfluorooctane sulfonic acid 118-122 interleukin 6 Homo sapiens 84-88 22358238-10 2012 gamma-Tocotrienol treatment also upregulated ELN and COL1A1 and downregulated MMP1 and IL6 expression in young and senescent fibroblasts. plastochromanol 8 0-17 interleukin 6 Homo sapiens 87-90 22449139-9 2012 It was also found that NF-kappaB inhibitor, but not ERK1/2 inhibitor, attenuated EDP-dependent induction of IL-1alpha, IL-1beta, and IL-6 expression, indicating that NF-kappaB pathways are required for EDP-induced IL-1alpha, IL-1beta, and IL-6 gene expression in human LF cells. 2-ethyl-3,5-dimethylpyrazine 81-84 interleukin 6 Homo sapiens 133-137 22449139-9 2012 It was also found that NF-kappaB inhibitor, but not ERK1/2 inhibitor, attenuated EDP-dependent induction of IL-1alpha, IL-1beta, and IL-6 expression, indicating that NF-kappaB pathways are required for EDP-induced IL-1alpha, IL-1beta, and IL-6 gene expression in human LF cells. 2-ethyl-3,5-dimethylpyrazine 81-84 interleukin 6 Homo sapiens 239-243 23885401-2 2012 The cholestatic effect of cytokines (e.g. IL-1beta, IL-6) is believed to result from the repression of genes that normally mediated the hepatic uptake, metabolism, and biliary excretion of bile salts and bilirubin. Bilirubin 204-213 interleukin 6 Homo sapiens 52-56 23206461-9 2012 CONCLUSIONS: Preincisional parecoxib administration reduced postoperative pain and morphine consumption compared with postincisional administration, and attenuated IL-6 and IL-8 production 24 h after hip replacement surgery. parecoxib 27-36 interleukin 6 Homo sapiens 164-168 23029307-9 2012 CONCLUSION: The data suggest that compared to inflammatory markers such as CRP and IL-6 serum uric acid levels may predict future CVD risk in patients with stable CHD with a risk increase even at levels considered normal. Uric Acid 94-103 interleukin 6 Homo sapiens 83-87 22396773-6 2012 Consistently, TPT-treated cells exhibit elevated expression of multiple cytokines such as IFN-beta, TNF-alpha, IL-6 and IL-8. Topotecan 14-17 interleukin 6 Homo sapiens 111-115 22950641-5 2012 Simvastatin resulted in a significant decrease in CRP, which correlated with decreases in both total (r = 0.87, p < 0.05) and low-density lipoprotein cholesterol, IL-6, sICAM-1, sVCAM-1, oxLDL, and sFas at 6 months, compared to baseline. Simvastatin 0-11 interleukin 6 Homo sapiens 166-170 21901530-13 2011 The cells will respond to the beta-adrenergic receptor agonist terbutaline resulting in reduced TNF-alpha and increased IL-10 and IL-6 production following CEA activation. Terbutaline 63-74 interleukin 6 Homo sapiens 130-134 21956421-11 2011 When treated with TSH, thyroid fibroblasts generate IL-6 and IL-8. Thyrotropin 18-21 interleukin 6 Homo sapiens 52-56 21680063-5 2011 Fifteen of the tested 7-hydroxycoumarins also inhibited IL-6 production but none of them had any major inhibitory effect on COX-2 expression. Umbelliferones 22-40 interleukin 6 Homo sapiens 56-60 21518763-0 2011 miR-365, a novel negative regulator of interleukin-6 gene expression, is cooperatively regulated by Sp1 and NF-kappaB. mir-365 0-7 interleukin 6 Homo sapiens 39-52 21518763-4 2011 Overexpression of miR-365 mimics decreased activity of a luciferase reporter containing the IL-6 3"-UTR and led to repression of IL-6 protein. mir-365 18-25 interleukin 6 Homo sapiens 92-96 21518763-4 2011 Overexpression of miR-365 mimics decreased activity of a luciferase reporter containing the IL-6 3"-UTR and led to repression of IL-6 protein. mir-365 18-25 interleukin 6 Homo sapiens 129-133 21518763-5 2011 In contrast, ectopic expression of a miR-365 inhibitor elevated IL-6 expression. mir-365 37-44 interleukin 6 Homo sapiens 64-68 21518763-9 2011 Furthermore, miR-365 exhibited a greater negative regulatory effect on IL-6 than hsa-let-7a, a previously identified microRNA negatively regulating IL-6. mir-365 13-20 interleukin 6 Homo sapiens 71-75 21518763-9 2011 Furthermore, miR-365 exhibited a greater negative regulatory effect on IL-6 than hsa-let-7a, a previously identified microRNA negatively regulating IL-6. mir-365 13-20 interleukin 6 Homo sapiens 148-152 21518763-10 2011 Taken together, our results show that miR-365 is a novel negative regulator of IL-6. mir-365 38-45 interleukin 6 Homo sapiens 79-83 21477202-10 2011 Our preliminary findings showing a dose-related effect of simvastatin on levels of NOx, CRP and IL-6 suggest a potential therapeutic role for simvastatin in SCD. Simvastatin 58-69 interleukin 6 Homo sapiens 96-100 21477202-10 2011 Our preliminary findings showing a dose-related effect of simvastatin on levels of NOx, CRP and IL-6 suggest a potential therapeutic role for simvastatin in SCD. Simvastatin 142-153 interleukin 6 Homo sapiens 96-100 21440087-3 2011 The secretion of the pro-inflammatory cytokines IL-1beta and IFNgamma and that of the anti-inflammatory cytokines IL-1ra and IL-10 induced by cancer cells was decreased by simvastatin but not by pravastatin, whereas that of IL-6 was not affected by both drugs. Simvastatin 172-183 interleukin 6 Homo sapiens 224-228 21609530-5 2011 RESULTS: 8-OHDG and IL-6 secretion of HUVECs was significantly increased significantly after incubated with oxLDL for 24 hours which could be significantly attenuated in the presence of tocopherols and EPA (alone or in combination, all P < 0.05) while the strongest inhibition effects were seen with combined use of mixed-tocopherols and EPA. Eicosapentaenoic Acid 202-205 interleukin 6 Homo sapiens 20-24 21609530-5 2011 RESULTS: 8-OHDG and IL-6 secretion of HUVECs was significantly increased significantly after incubated with oxLDL for 24 hours which could be significantly attenuated in the presence of tocopherols and EPA (alone or in combination, all P < 0.05) while the strongest inhibition effects were seen with combined use of mixed-tocopherols and EPA. Eicosapentaenoic Acid 341-344 interleukin 6 Homo sapiens 20-24 21609530-8 2011 CONCLUSION: Combined mixed-tocopherols + EPA use enhanced the inhibiting effects on the secretion of 8-OHDG and IL-6 in oxLDL stimulated HUVECs which might be linked with increased SOD activity and reduced p-PKC activity. Eicosapentaenoic Acid 41-44 interleukin 6 Homo sapiens 112-116 21302967-3 2011 This sesquiterpenoid inhibited the secretion and expression of IL-6 in phorbol 12-myristate 13-acetate- and calcium ionophore A23187-stimulated human mast cells (HMC)-1. Calcimycin 126-132 interleukin 6 Homo sapiens 63-67 20950789-2 2011 We hypothesized that, in patients with elevated IL-6, vitamin C and alpha-fetoprotein may provide protection from spontaneous preterm delivery through antioxidant functions. Ascorbic Acid 54-63 interleukin 6 Homo sapiens 48-52 2594609-2 1989 Compound AR 12456 influenced this pathway in a selective way: it enhanced the uptake and degradation of 125I-LDL by Hep G2 cells in a dose-dependent manner, but inhibited it in HSF. Argon 9-11 interleukin 6 Homo sapiens 177-180 6573232-2 1983 In initial experiments, the inhibitory action of histamine-induced suppressor factor (HSF) on lymphocyte proliferation was documented to be reduced by the addition of indomethacin (1 microgram/ml). Indomethacin 167-179 interleukin 6 Homo sapiens 49-84 6573232-2 1983 In initial experiments, the inhibitory action of histamine-induced suppressor factor (HSF) on lymphocyte proliferation was documented to be reduced by the addition of indomethacin (1 microgram/ml). Indomethacin 167-179 interleukin 6 Homo sapiens 86-89 6573232-3 1983 Moreover, the addition of exogeneous PGE2 (10(-7)-10(-8) M) to mononuclear cell cultures reconstituted HSF activity in the presence of indomethacin. Indomethacin 135-147 interleukin 6 Homo sapiens 103-106 6573232-6 1983 Monocytes (but not lymphocytes) incubated with supernatants containing HSF increased their production of prostaglandin E2, F2 alpha, and thromboxane B2 by 169, 53, and 49%, respectively. f2 alpha 123-131 interleukin 6 Homo sapiens 71-74 33169272-11 2021 On secretion level, the combination of compression and zoledronate induced a slightly increase of IL-6 secretion. Zoledronic Acid 55-66 interleukin 6 Homo sapiens 98-102 3278321-6 1988 CDF is first enriched by three successive chromatographic procedures that utilize anion exchange, hydroxyapatite, and phenyl-Superose. Durapatite 98-112 interleukin 6 Homo sapiens 0-3 33907855-0 2021 Non-toxic sulfur inhibits LPS-induced inflammation by regulating TLR-4 and JAK2/STAT3 through IL-6 signaling. Sulfur 10-16 interleukin 6 Homo sapiens 94-98 33243082-7 2021 The inflammatory markers, ferritin, interleukin-6 and procalcitonin were significantly increased in LMWH-untreated patients (p values < 0.05). Heparin, Low-Molecular-Weight 100-104 interleukin 6 Homo sapiens 36-49 34052657-7 2021 RESULTS: After GBS, HOMA-IR, CRP and IL-6 serum levels decreased. gbs 15-18 interleukin 6 Homo sapiens 37-41 34035828-9 2021 Further analysis showed that the HGD activity of quercetin, formononetin, kaempferol, isorhamnetin, and beta-sitosterol ingredients is possible through VEGFA, IL6, TNF, AKT1, and TP53 targets involved in TNF, toll-like receptors, and MAPK-related pathways, which have anti-inflammatory, antiapoptosis, antioxidation, and autophagy effects, relieve renal fibrosis and renal cortex injury, and improve renal function, thus delaying the development of DN. 3-methylquercetin 86-98 interleukin 6 Homo sapiens 159-162 34035828-10 2021 The molecular docking results showed that quercetin, formononetin, kaempferol, isorhamnetin, beta-sitosterol had a good binding activity with VEGFA, IL6, TNF, AKT1, and TP53. 3-methylquercetin 79-91 interleukin 6 Homo sapiens 149-152 33421881-8 2021 Arginine and vitamin B6 supplemented into cell culture effectively decreased the levels of IL-6 and IL-8. Vitamin B 6 13-23 interleukin 6 Homo sapiens 91-95 33951210-6 2021 Maternal selenium level was found to be negatively correlated with gestational week (p<0.0001,r:-0,541), D-dimer(p:0.0002,r:-0.363) and IL-6 level (p:0.02,r:-0.243). Selenium 9-17 interleukin 6 Homo sapiens 136-140 33951210-11 2021 The decrease in maternal selenium level was found to be related with IL-6, D-dimer levels which indicates selenium role on disease progression. Selenium 25-33 interleukin 6 Homo sapiens 69-73 32748168-11 2021 Additionally, the levels of estimated cytokines suggested a predominant pro-inflammatory response in Pb-exposed workers with significant increase in IL-4, IL-6, and TNF-alpha, and a significant decrease in IL-2 and IL-10. Lead 101-103 interleukin 6 Homo sapiens 155-159 33791002-8 2021 Compared with the lipopolysaccharide (LPS) group, the contents of IL-6, IL-1beta, TNF-alpha and PGE-2 in the culture supernatant were significantly declined in the leflunomide + LPS and intervention+LPS groups, as well as the mRNA expression levels of HIF-1alpha, VEGFA and TLR4. Leflunomide 164-175 interleukin 6 Homo sapiens 66-70 33962178-0 2021 A highly selective and stable cationic polyelectrolyte encapsulated black phosphorene based impedimetric immunosensor for Interleukin-6 biomarker detection. phosphorene 74-85 interleukin 6 Homo sapiens 122-135 33975149-9 2021 RESULTS: Controlling for negative affect, body mass index, age, and sex, PA significantly moderated the associations between sleep condition and stimulated monocyte production of IL-6 (b = -1.03, t = -2.02, p = .048) and its co-expression with TNF (b = -0.93, t = -2.00, p = .049), such that inflammatory responses were blunted among those high in PA with increases principally among those low in PA. Protactinium 348-350 interleukin 6 Homo sapiens 179-183 33975149-9 2021 RESULTS: Controlling for negative affect, body mass index, age, and sex, PA significantly moderated the associations between sleep condition and stimulated monocyte production of IL-6 (b = -1.03, t = -2.02, p = .048) and its co-expression with TNF (b = -0.93, t = -2.00, p = .049), such that inflammatory responses were blunted among those high in PA with increases principally among those low in PA. Protactinium 348-350 interleukin 6 Homo sapiens 179-183 33903806-9 2021 Significant positive correlations were observed between metabolites (including pseudouridine, l-phenylalanine, and p-hydroxyphenylacetic acid) and IL-6 levels only in ESRD group. Pseudouridine 79-92 interleukin 6 Homo sapiens 147-151 33900308-6 2021 Syringic acid and kuromanin, standard compounds found in FBBBR, significantly decreased the interleukin (IL)-1beta, IL-6 and IL-8 levels in PM2.5-treated HaCaT cells. cyanidin 3-O-glucopyranoside 18-27 interleukin 6 Homo sapiens 116-120 33839697-5 2021 LCZ696 inhibits LPS-induced expressions and secretions of the pro-inflammatory cytokines, interleukin-6 (IL-6), interleukin-1alpha (IL-1alpha), and tumor necrosis factor beta (TNF-beta) as well as the chemokines, monocyte chemotactic protein 1 (MCP-1), and chemokine (C-X-C motif) ligand 1 protein (CXCL1). sacubitril and valsartan sodium hydrate drug combination 0-6 interleukin 6 Homo sapiens 90-103 33839697-5 2021 LCZ696 inhibits LPS-induced expressions and secretions of the pro-inflammatory cytokines, interleukin-6 (IL-6), interleukin-1alpha (IL-1alpha), and tumor necrosis factor beta (TNF-beta) as well as the chemokines, monocyte chemotactic protein 1 (MCP-1), and chemokine (C-X-C motif) ligand 1 protein (CXCL1). sacubitril and valsartan sodium hydrate drug combination 0-6 interleukin 6 Homo sapiens 105-109 32865318-12 2021 Isorhamnetin significantly decreased the expression of interleukin (IL)-1beta, IL-6, IL-8, and C-X-C motif chemokine ligand 10 in BEAS-2B cells induced by TNF-alpha. 3-methylquercetin 0-12 interleukin 6 Homo sapiens 79-83 33675858-6 2021 Results showed that luteolin mitigated BDE-209-induced damage to intestinal epithelial barrier by reducing the levels of reactive oxygen species (ROS), increasing the activity of superoxide dismutase (SOD) and glutathione (GSH), suppressed the secretion of pro-inflammatory cytokines (TNF-alpha, IL-6, and IL-1beta), and increased the expression of tight junction (TJ) proteins (ZO-1, occludin, and claudin-1). decabromobiphenyl ether 39-46 interleukin 6 Homo sapiens 296-300 33998890-6 2021 Results: In astrocytes CBG and CBDV attenuated levels of interleukin-6 (IL-6) and lactate dehydrogenase (LDH), whereas CBDV (10 nM-10 muM) also decreased vascular endothelial growth factor (VEGF) secretion. cannabidivarin 31-35 interleukin 6 Homo sapiens 57-70 33998890-6 2021 Results: In astrocytes CBG and CBDV attenuated levels of interleukin-6 (IL-6) and lactate dehydrogenase (LDH), whereas CBDV (10 nM-10 muM) also decreased vascular endothelial growth factor (VEGF) secretion. cannabidivarin 31-35 interleukin 6 Homo sapiens 72-76 33516376-0 2021 A novel QCM immunosensor development based on gold nanoparticles functionalized sulfur-doped graphene quantum dot and h-ZnS-CdS NC for Interleukin-6 detection. Sulfur 80-86 interleukin 6 Homo sapiens 135-148 33516376-3 2021 A novel quartz crystal microbalance (QCM) immunoassay method was presented for high sensitivity and selectivity detection of interleukin-6 (IL-6) based on gold nanoparticles functionalized sulfur-doped graphene quantum dot (AuNPs/S-GQD) and hollow ZnS-CdS nanocage (h-ZnS-CdS NC). Sulfur 189-195 interleukin 6 Homo sapiens 125-138 33516376-3 2021 A novel quartz crystal microbalance (QCM) immunoassay method was presented for high sensitivity and selectivity detection of interleukin-6 (IL-6) based on gold nanoparticles functionalized sulfur-doped graphene quantum dot (AuNPs/S-GQD) and hollow ZnS-CdS nanocage (h-ZnS-CdS NC). Sulfur 189-195 interleukin 6 Homo sapiens 140-144 33516376-4 2021 Firstly, AuNPs/S-GQD nanocomposite was synthesized in the presence of tetrachloroauric acid and then conjugated onto anti-IL-6 antibodies by amino-gold affinity. amino-gold 141-151 interleukin 6 Homo sapiens 122-126 33842606-5 2021 Results: LUTX on ECMO and pulmonary endarterectomy (PEA) on CPB triggered an immediate increase in cytokine serum concentrations at end of surgery: IL-6: 66-fold and 71-fold, IL-10: 3-fold and 2.5-fold, ST2/IL-33R: 5-fold and 4-fold and SOFA: 10.5+-2.8 and 10.7+-1.7, that decreased sharply to baseline levels from postoperative day 1-5. lutx 9-13 interleukin 6 Homo sapiens 148-152 32900520-14 2021 Interleukin 6 (0.15 pg/mL; p = 0.039) and tumor necrosis factor alpha (0.18 pg/mL; p = 0.005), but not high-sensitivity C-reactive protein, were higher on stearic acid. stearic acid 155-167 interleukin 6 Homo sapiens 0-13 33643041-4 2020 Bazedoxifene inhibits IL-6/STAT3 signaling in cancer cells, but its effect on the Th17 immune response induced by myocarditis remains unknown. bazedoxifene 0-12 interleukin 6 Homo sapiens 22-26 33169272-13 2021 Further addition of zoledronate to pre-stimulated cells additionally strengthened the compression-induced upregulation of COX-2 and IL-6 expression as well as protein secretion compared to all other groups. Zoledronic Acid 20-31 interleukin 6 Homo sapiens 132-136 33528893-10 2021 HCQ did not affect insulin clearance but decreased circulating IL-6 (P=0.01) and increased adiponectin (P=0.045). Hydroxychloroquine 0-3 interleukin 6 Homo sapiens 63-67 33992179-9 2021 Fluoxetine may potentially reduce pro-inflammatory chemokine/cytokines levels (such as CCL-2, IL-6, and TNF-alpha) in COVID-19 patients. Fluoxetine 0-10 interleukin 6 Homo sapiens 94-98 34057124-4 2021 OBJECTIVE: This study aims to determine the effect of Dorsata honey (DH) as a complementary therapy to IL-6 levels and T lymphocytes of post-chemotherapy in breast cancer. dorsata honey 54-67 interleukin 6 Homo sapiens 103-107 33958662-5 2021 Exogenous 11,12-EET and 19,20-EDP significantly decreased PA- and IL-1beta-induced MC expression of IL-1beta and IL-6. 19(20)-EpDPE 24-33 interleukin 6 Homo sapiens 113-117 33562298-7 2021 However, co-treatment with TUDCA alleviated inflammatory response induced by IL-1beta, as shown by down regulation of Il-1beta, Il-6, Il-8 and Cox2, and increased the expression of antioxidant enzyme Sod2. ursodoxicoltaurine 27-32 interleukin 6 Homo sapiens 128-132 21118681-6 2011 Furthermore, acarbose gave a decrease of fasting plasma insulin, post-prandial insulin, s-ICAM-1, sVCAM-1, IL-6, and Hs-CRP, not observed with placebo, even if no significant differences between the two groups were observed. Acarbose 13-21 interleukin 6 Homo sapiens 107-111 33140256-0 2021 Letter to the editor regarding the article "Bazedoxifene is a novel IL-6/GP130 inhibitor for treating triple-negative breast cancer". bazedoxifene 44-56 interleukin 6 Homo sapiens 68-72 33961943-0 2021 Hydroxychloroquine reduces interleukin-6 levels after myocardial infarction: The randomized, double-blind, placebo-controlled OXI pilot trial. Hydroxychloroquine 0-18 interleukin 6 Homo sapiens 27-40 33961943-5 2021 At six months, the IL-6 levels were lower in the hydroxychloroquine group (p = 0.042, between groups), and in the on-treatment analysis, the difference at this time point was even more pronounced (p = 0.019, respectively). Hydroxychloroquine 49-67 interleukin 6 Homo sapiens 19-23 33961943-8 2021 CONCLUSIONS: In patients with myocardial infarction, hydroxychloroquine reduced IL-6 levels significantly more than did placebo without causing any clinically significant adverse events. Hydroxychloroquine 53-71 interleukin 6 Homo sapiens 80-84 21747711-5 2011 Interleukin-6 and tumor necrosis factor-alpha levels in the lipopolysaccharide-induced peripheral blood mononuclear cell supernates were significantly reduced by spermine and/or alpha2-Heremans-Schmid glycoprotein. Spermine 162-170 interleukin 6 Homo sapiens 0-45 33975149-9 2021 RESULTS: Controlling for negative affect, body mass index, age, and sex, PA significantly moderated the associations between sleep condition and stimulated monocyte production of IL-6 (b = -1.03, t = -2.02, p = .048) and its co-expression with TNF (b = -0.93, t = -2.00, p = .049), such that inflammatory responses were blunted among those high in PA with increases principally among those low in PA. Protactinium 73-75 interleukin 6 Homo sapiens 179-183 33981768-3 2021 This study was aimed at demonstrating that the levels of IL-6 and the number of myeloid-derived suppressor cells (MDSCs), with a positive correlation between them, increased in MIBC tissues, promoting MIBC cell proliferation, especially in patients with recurrence. 4-METHYL-2-PENTANOL 177-181 interleukin 6 Homo sapiens 57-61 33981768-7 2021 These data suggested that IL-6 promoted MIBC progression by not only accelerating proliferation but also improving the immune suppression ability of MDSCs through activating the MAPK signaling pathway. 4-METHYL-2-PENTANOL 40-44 interleukin 6 Homo sapiens 26-30 33522342-8 2021 IL-6 levels decreased significantly in the pravastatin group (mean +- SD): (191.87 +- 82.99 vs. 151.85 + 48.46, p = .013), while levels in the control group did not change significantly (median (interquartile range)) (144.17 (53.91) vs. 140.82 (16.18), p = .177). Pravastatin 43-54 interleukin 6 Homo sapiens 0-4 33522342-14 2021 CONCLUSION: Administration of 40 mg pravastatin resulted in an improvement in NO levels, and a decrease in IL-6 and endothelin (ET-1) levels. Pravastatin 36-47 interleukin 6 Homo sapiens 107-111 33584641-7 2020 Exposure to extracellular heme in SCD can also augment the expression of placental growth factor (PlGF) and interleukin-6 (IL-6), with important consequences to enthothelin-1 (ET-1) secretion and pulmonary hypertension, and potentially the development of renal and cardiac dysfunction. Heme 26-30 interleukin 6 Homo sapiens 108-121 22121382-9 2011 The NF-kappaB inhibitor BAY-117085 inhibited only RV-induced IL-6 (P<0.05) and dimethyl fumarate did not alter RV-induced IL-6 and IL-8. BAY 11-7085 24-34 interleukin 6 Homo sapiens 61-65 33584641-7 2020 Exposure to extracellular heme in SCD can also augment the expression of placental growth factor (PlGF) and interleukin-6 (IL-6), with important consequences to enthothelin-1 (ET-1) secretion and pulmonary hypertension, and potentially the development of renal and cardiac dysfunction. Heme 26-30 interleukin 6 Homo sapiens 123-127 33584641-9 2020 A special emphasis is given to heme-induced PlGF and IL-6 related mechanisms and their role in SCD disease progression. Heme 31-35 interleukin 6 Homo sapiens 53-57 33584652-10 2020 Interestingly, in exploratory analysis, LTBI+ TB progressors had significantly higher levels of IL1beta, IL-6 and IL-13 in multivariable models compared to LTBI+ non-progressors. Terbium 41-43 interleukin 6 Homo sapiens 105-109 33875799-8 2021 Omega-3 also reduced overall cortisol (p = 0.03) and IL-6 (p = 0.03) throughout the stressor; the 2.5 g/d group had 19% and 33% lower overall cortisol levels and IL-6 geometric mean levels, respectively, compared to the placebo group. omega-3 0-7 interleukin 6 Homo sapiens 53-57 21059338-0 2010 High molecular weight hyaluronic acid inhibits IL-6-induced MMP production from human chondrocytes by up-regulating the ERK inhibitor, MKP-1. Hyaluronic Acid 22-37 interleukin 6 Homo sapiens 47-51 33131052-5 2021 While zoledronate induced mRNA expressions of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-6, and interferon-gamma (IFN-gamma) in PBMC, depletion of gammadelta T cells abolished that zoledronate-induced expression of those cytokines, indicating the necessity of gammadelta T cells for expression induction by zoledronate. Zoledronic Acid 6-17 interleukin 6 Homo sapiens 111-115 33131052-7 2021 Since it is generally accepted that monocytes and macrophages are primary sources of inflammatory cytokines, CD14+ cells from PBMC were exposed to zoledronate in the presence of PBMC, which resulted in induced expression of mRNAs for IL-1beta, IL-6, and IFN-gamma, but not for TNF-alpha. Zoledronic Acid 147-158 interleukin 6 Homo sapiens 244-248 33131052-8 2021 These results indicate that CD14+ cells are responsible, at least in part, for the production of IL-1beta, IL-6, and IFN-gamma in blood exposed to zoledronate. Zoledronic Acid 147-158 interleukin 6 Homo sapiens 107-111 33375871-6 2021 The increased TNF-alpha, IL-1beta, and IL-6 productions in OGD/R-induced hippocampal neurons were decreased after treatment with JZL184. JZL 184 129-135 interleukin 6 Homo sapiens 39-43 33180478-7 2020 VPP and IPP reduced the protein levels of IL-6 to 227.34 +- 10.56 and 273.84 +- 22.28 pg/mL, of IL-1beta protein to 131.56 +- 23.18 and 221.14 +- 13.8 pg/mL, and of MCP-1 to 301.48 +- 19.75 and 428.68 +- 9.59 pg/mL. valyl-prolyl-proline 0-3 interleukin 6 Homo sapiens 42-46 21059338-1 2010 To investigate the mechanism of the inhibitory action of high molecular weight hyaluronic acid (HA) on production of matrix metalloproteinases (MMPs) induced by IL-6 in human chondrocyte. Hyaluronic Acid 79-94 interleukin 6 Homo sapiens 161-165 21059338-1 2010 To investigate the mechanism of the inhibitory action of high molecular weight hyaluronic acid (HA) on production of matrix metalloproteinases (MMPs) induced by IL-6 in human chondrocyte. Hyaluronic Acid 96-98 interleukin 6 Homo sapiens 161-165 21036722-7 2010 RESULTS: DPV576 treatment of DCs resulted in: (i) increased CD83 and CD86 expression on DCs, (ii) up-regulation in the levels of DC-secreted cytokines IL-6, TNF and IL-10, and (iii) increased ability to induce proliferation in CD4(+) T-cells which is associated with increased expression of T-cell activation marker CD25. dpv576 9-15 interleukin 6 Homo sapiens 151-155 33245731-8 2020 TMPRSS2, inflammatory cytokines G-CSF, M-CSF, IL-1alpha, IL-6 and MCP-1 are suppressed by MEKi alone or with remdesivir. remdesivir 109-119 interleukin 6 Homo sapiens 57-61 32961186-7 2020 Bj5-ta cells stimulated with liposaccharides (LPS), presented a reduction of 86% on IL-6 cytokine levels, after exposure to chitosan with 5% EtPUAE film extract. bj5-ta 0-6 interleukin 6 Homo sapiens 84-88 33204288-12 2020 Molecular docking showed that quercetin, kaempferol, baicalein, and wogonin have good binding activity with IL6, VEGFA, EGFR, and NFKBIA targets. baicalein 53-62 interleukin 6 Homo sapiens 108-111 33347820-3 2021 We previously described a small-molecule compound, Bazedoxifene, which target IL-6/STAT3 pathway and has been approved for clinical use for osteoporosis in postmenopausal women. bazedoxifene 51-63 interleukin 6 Homo sapiens 78-82 33427831-5 2021 The Bax/Bcl2 expression ratio was increased up to 11-fold in cells pre-treated with 60 muM limonoids for 48 h. Apart from this, the limonoids also induced the expression of p21, and exhibited anti-inflammatory activity through decreasing the expression of cox-2, NF-kappaB and IL-6. Limonins 132-141 interleukin 6 Homo sapiens 277-281 20632037-6 2010 Serum IL-6 was significantly higher in the APN group than in the group with lower UTI (p<0.05). apholate 43-46 interleukin 6 Homo sapiens 6-10 32940862-0 2021 Raloxifene inhibits pancreatic adenocarcinoma growth by interfering with ERbeta and IL-6/gp130/STAT3 signaling. Raloxifene Hydrochloride 0-10 interleukin 6 Homo sapiens 84-88 32881340-7 2020 Remarkably, IL-6 levels were significantly reduced after LMWH treatment (P = 0.006), indicating that, besides other beneficial properties, LMWH may exert an anti-inflammatory effect and attenuate in part the "cytokine storm" induced by the virus. Heparin, Low-Molecular-Weight 57-61 interleukin 6 Homo sapiens 12-16 32881340-7 2020 Remarkably, IL-6 levels were significantly reduced after LMWH treatment (P = 0.006), indicating that, besides other beneficial properties, LMWH may exert an anti-inflammatory effect and attenuate in part the "cytokine storm" induced by the virus. Heparin, Low-Molecular-Weight 139-143 interleukin 6 Homo sapiens 12-16 32940862-4 2021 To test this hypothesis, we studied the impact of raloxifene on interleukin-6/glycoprotein-130/signal transducer and activator of transcription-3 (IL-6/gp130/STAT3) signaling. Raloxifene Hydrochloride 50-60 interleukin 6 Homo sapiens 64-77 20843335-3 2010 The aim of this study was to evaluate the effects of PHT and its metabolite, 5-(p-hydroxyphenyl-), 5-phenylhydantoin (HPPH) on LPS-elicited MMP, TIMP, TNF-alpha and IL-6 levels in macrophages. Phenytoin 53-56 interleukin 6 Homo sapiens 165-169 32940862-4 2021 To test this hypothesis, we studied the impact of raloxifene on interleukin-6/glycoprotein-130/signal transducer and activator of transcription-3 (IL-6/gp130/STAT3) signaling. Raloxifene Hydrochloride 50-60 interleukin 6 Homo sapiens 147-151 32940862-7 2021 The effects of raloxifene on IL-6 expression and STAT3 phosphorylation in PDAC cells were assessed by ELISA and Western blotting, respectively. Raloxifene Hydrochloride 15-25 interleukin 6 Homo sapiens 29-33 33565825-9 2021 Under triamcinolone treatment, suppressed levels of IL-6 and MMP-9 in seroma fluid were observed. Triamcinolone 6-19 interleukin 6 Homo sapiens 52-56 33332480-3 2020 Upadacitinib tartrate (Rinvoq), a selective and reversible JAK1 inhibitor, inhibited interleukin (IL)-6 and IL-7 and ameliorated adjuvant-induced arthritis in preclinical studies. upadacitinib 23-29 interleukin 6 Homo sapiens 85-103 32985128-7 2020 RESULTS: Children exposed to higher IL-1beta, IL-6, IL-8, and IL-10 concentrations had lower BMIz at birth but higher BMIz during childhood. bmiz 93-97 interleukin 6 Homo sapiens 46-50 20603779-6 2010 In experiments on adipocytes treated at day 14 post-differentiation, JTE-907, a synthetic cannabinoid, upregulated the expression of key inflammatory markers - IL-6, MCP-1 and IL-1 beta - and angiogenic factors - VEGF and ANGPTL4 - at 10 microM after 20 h of treatment, having also increased the expression of TRPV1 at 10 microM. Cannabinoids 90-101 interleukin 6 Homo sapiens 160-164 33045633-6 2020 Correspondingly, PA-X decreases the amount of NF-kappaB signaling pathway-associated genes, including TNF-alpha, Nos2, IL-6 and IL-2. pa-x 17-21 interleukin 6 Homo sapiens 119-123 33645093-10 2021 The molecular docking results showed that the main active components(quercetin, kaempferol, beta-sitosterol, luteolin, stigmasterol and baicalein) of Xuefu Zhuyu Decoction in the treatment of myocardial infarction had good binding properties with the core proteins IL6, ALB, VEGFA, TNF, MAPK3 and CASP3. baicalein 136-145 interleukin 6 Homo sapiens 265-268 20562702-7 2010 The trial was terminated because of a lack of effect of TAK-242 in suppressing serum interleukin-6 levels. ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate 56-63 interleukin 6 Homo sapiens 85-98 33530480-4 2021 Moreover, KMU-1170 suppressed LPS-induced upregulation of proinflammatory cytokines such as IL-1beta, TNF-alpha, and IL-6, and, notably, inhibited LPS-induced upregulation of the NLRP3 inflammasome in THP-1 cells. kmu-1170 10-18 interleukin 6 Homo sapiens 117-121 33530480-5 2021 Importantly, KMU-1170 attenuated LPS-mediated inflammatory responses in human osteoarthritic FLS, such as the upregulation of IL-1beta, TNF-alpha, IL-6, iNOS, and COX-2 and the phosphorylation of IKKalpha/beta and NF-kappaB p65. kmu-1170 13-21 interleukin 6 Homo sapiens 147-151 33192498-8 2020 At the cellular and molecular level, the CD4, CD8, CD4/CD8, IL-6, TNF-alpha, and CRP levels were significantly improved when CM was complemented with XFG. 3-[(2~{S},3~{R},4~{R})-4-azanyl-2-carboxy-pyrrolidin-3-yl]propyl-$l^{3}-oxidanyl-bis(oxidanyl)boron 150-153 interleukin 6 Homo sapiens 60-64 32534297-9 2020 Anti-inflammatory IL-1RA concentration was negatively related with Pb, Cd, Hg and As, while pro-inflammatory IL-1beta and IL-6 were positively correlated with Pb. Lead 159-161 interleukin 6 Homo sapiens 122-126 32390406-13 2021 Furthermore, astragalin reduced the level of phosphorylated IkappaBalpha and decreased the production of the inflammatory cytokines IL-6, IL-8, and TNF-alpha in the DSS-treated colon mucosa. astragalin 13-23 interleukin 6 Homo sapiens 132-136 33155234-0 2020 Observation of the efficacy of naloxone combined with acyclovir in the treatment of children viral encephalitis and its impacts on IL-1 and IL-6. Naloxone 31-39 interleukin 6 Homo sapiens 140-144 20438865-4 2010 All three muropeptides induced TNF-alpha and IL-6 production by Mphi (GM-3P>GM-4P>>(GM-4P)(2)), but failed to trigger TNF-alpha, IL-6 and IL-12p70 production by immature DCs. muropeptides 10-22 interleukin 6 Homo sapiens 45-49 33155234-1 2020 OBJECTIVE: To analyze the clinical efficacy of naloxone combined with acyclovir in the treatment of children viral encephalitis and the impacts on inflammatory factors IL-1 and IL-6. Naloxone 47-55 interleukin 6 Homo sapiens 177-181 33155234-13 2020 CONCLUSIONS: In the treatment of children, viral encephalitis has naloxone combined with ganciclovir had a more significant effect on the decrease of levels of serum IL-1 and IL-6; naloxone combined with acyclovir in the treatment of children viral encephalitis had better effects, lower adverse reactions and lower prevalence of sequelae compared with sole medication, which is worth clinical promotion. Naloxone 66-74 interleukin 6 Homo sapiens 175-179 32755990-8 2020 DHT pre-treatment inhibited LPS induced-mRNA expression of several pro-inflammatory mediators (i.e. COX2, IL6, IL12A and IFNgamma), effect significantly blunted by AR antagonist bicalutamide. bicalutamide 178-190 interleukin 6 Homo sapiens 106-109 33628184-8 2020 Our in vivo experiments showed that Pristimerin remarkably ameliorated ovariectomy-induced bone loss, reduced serum levels of TNF-alpha, IL-1beta, IL-6, and RANKL, and increased serum level of osteoprotegerin (OPG). pristimerin 36-47 interleukin 6 Homo sapiens 147-151 33167270-1 2021 An ultrasensitive immunosensor based on acetylene black (AB)/epoxy-substituted-poly(pyrrole) polymer (EpxS-PPyr) composite coated disposable indium tin oxide (ITO) electrode was fabricated for interleukin 6 (IL 6) detection. epoxy-substituted-poly(pyrrole) polymer 61-100 interleukin 6 Homo sapiens 193-206 33167270-1 2021 An ultrasensitive immunosensor based on acetylene black (AB)/epoxy-substituted-poly(pyrrole) polymer (EpxS-PPyr) composite coated disposable indium tin oxide (ITO) electrode was fabricated for interleukin 6 (IL 6) detection. epoxy-substituted-poly(pyrrole) polymer 61-100 interleukin 6 Homo sapiens 208-212 20438865-4 2010 All three muropeptides induced TNF-alpha and IL-6 production by Mphi (GM-3P>GM-4P>>(GM-4P)(2)), but failed to trigger TNF-alpha, IL-6 and IL-12p70 production by immature DCs. muropeptides 10-22 interleukin 6 Homo sapiens 138-142 33431967-7 2021 CO2 suppressed the UVB-induced production of tumor necrosis factor-alpha (TNFalpha) and interleukin-6 (IL-6) in keratinocytes and the 3D epidermis. Carbon Dioxide 0-3 interleukin 6 Homo sapiens 88-101 32832941-7 2020 However, while Uro A dramatically reduced IL-6 and IL-10 mRNA expression, no effect could be observed with ellagic acid. 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one 15-20 interleukin 6 Homo sapiens 42-46 33431967-7 2021 CO2 suppressed the UVB-induced production of tumor necrosis factor-alpha (TNFalpha) and interleukin-6 (IL-6) in keratinocytes and the 3D epidermis. Carbon Dioxide 0-3 interleukin 6 Homo sapiens 103-107 20430366-2 2010 The present study was conducted to assess the association between IL-6 (-174 G/C) gene polymorphism and GO in renal transplant recipients under cyclosporine (CsA), tacrolimus (Tcr), or sirolimus (Sir)-based regimens. Tacrolimus 164-174 interleukin 6 Homo sapiens 66-70 33431967-8 2021 Correcting medium acidification with NaOH inhibited the CO2-induced suppression of TNFalpha and IL-6 expression in keratinocytes. Carbon Dioxide 56-59 interleukin 6 Homo sapiens 96-100 32564453-8 2020 RESULTS: Compared to PF and PQ groups, mRNA and protein expression of IL-6, IL-8, and IL-1beta increased in samples from the BAK group in a time-dependent fashion, whereas all other cytokines showed a non-significant increase. Benzalkonium Compounds 125-128 interleukin 6 Homo sapiens 70-74 33371813-9 2021 In particular, Rg3 significantly reversed IL-6-induced EMT promotion and blocked IL-6- induced NICD and Hes1 upregulations. ginsenoside Rg3 15-18 interleukin 6 Homo sapiens 42-46 20430640-5 2010 To reduce non-specific binding, a mixed self-assembled monolayer of mercaptoundecanoic acid (MUA) and mercaptohexanol (MCH) was attached to the sensor, and then used for IL-6 determination using a sandwich type immunoassay. mercaptohexanol 102-117 interleukin 6 Homo sapiens 170-174 33371813-9 2021 In particular, Rg3 significantly reversed IL-6-induced EMT promotion and blocked IL-6- induced NICD and Hes1 upregulations. ginsenoside Rg3 15-18 interleukin 6 Homo sapiens 81-85 32871847-2 2020 Raloxifene and bazedoxifene inhibit IL-6 signaling at therapeutic doses, suggesting they have the potential to prevent the cytokine storm, ARDS and mortality in severe COVID-19 patients, as is being shown with humanized antibodies blocking IL-6 signaling. Raloxifene Hydrochloride 0-10 interleukin 6 Homo sapiens 36-40 32871847-2 2020 Raloxifene and bazedoxifene inhibit IL-6 signaling at therapeutic doses, suggesting they have the potential to prevent the cytokine storm, ARDS and mortality in severe COVID-19 patients, as is being shown with humanized antibodies blocking IL-6 signaling. Raloxifene Hydrochloride 0-10 interleukin 6 Homo sapiens 240-244 32871847-2 2020 Raloxifene and bazedoxifene inhibit IL-6 signaling at therapeutic doses, suggesting they have the potential to prevent the cytokine storm, ARDS and mortality in severe COVID-19 patients, as is being shown with humanized antibodies blocking IL-6 signaling. bazedoxifene 15-27 interleukin 6 Homo sapiens 36-40 32871847-2 2020 Raloxifene and bazedoxifene inhibit IL-6 signaling at therapeutic doses, suggesting they have the potential to prevent the cytokine storm, ARDS and mortality in severe COVID-19 patients, as is being shown with humanized antibodies blocking IL-6 signaling. bazedoxifene 15-27 interleukin 6 Homo sapiens 240-244 33279931-5 2020 Consequently, abrogation of STAT3 or IL6R expression in Med8A-R led to restored chemosensitivity to vincristine, highlighting a prominent role for canonical IL-6/STAT3 signaling in acquired drug resistance. Vincristine 100-111 interleukin 6 Homo sapiens 157-161 33279931-6 2020 Furthermore, Med8A-S subjected to conditioning exposure with IL-6, termed Med8A-IL6+ cells, exhibited enhanced vincristine resistance, increased expression of pY705-STAT3 and IL6R, and increased secretion of IL-6. Vincristine 111-122 interleukin 6 Homo sapiens 61-65 33279931-6 2020 Furthermore, Med8A-S subjected to conditioning exposure with IL-6, termed Med8A-IL6+ cells, exhibited enhanced vincristine resistance, increased expression of pY705-STAT3 and IL6R, and increased secretion of IL-6. Vincristine 111-122 interleukin 6 Homo sapiens 80-83 19427777-5 2010 Interleukin (IL)-1beta, IL-6 and tumor necrosis factor-alpha secretion from EPA, DHA and control cells were differentially limited by LPS concentration. Eicosapentaenoic Acid 76-79 interleukin 6 Homo sapiens 24-60 33541500-7 2020 The results of Meta analysis showed that PaO2/FiO2 increased in the low molecular weight heparin group compared with the conventional treatment group [mean difference (MD) = 72.08, 95% confidence interval (95%CI) was 56.92-87.24, P < 0.000 01], APACHE II (MD = -4.34, 95%CI was -5.73 to -2.96, P < 0.000 01), IL-6 [standardized mean difference (SMD) = -2.13, 95%CI was -2.71 to -1.56, P < 0.000 01] and 7-day mortality [relative risk (RR) = 0.52, 95%CI was 0.30-0.90, P = 0.02] and 28-day mortality (RR = 0.55, 95%CI was 0.34-0.90, P = 0.02) were significantly reduced, APTT was significantly shortened (MD = -0.88, 95%CI was -1.51 to -0.26, P = 0.006); but PT (MD = -0.44, 95%CI was -1.23 to 0.36, P = 0.28) and PLT (MD = -0.08, 95%CI was -18.81 to 18.65, P = 0.99) between the two groups had no statistically significant differences. Heparin, Low-Molecular-Weight 68-96 interleukin 6 Homo sapiens 309-313 32747326-0 2020 An increase in IL-6 levels at 6-month follow-up visit is associated with SSRI-emergent suicidality in high-risk children and adolescents treated with fluoxetine. Fluoxetine 150-160 interleukin 6 Homo sapiens 15-19 32858974-0 2020 The Endogenous Opioid System in Schizophrenia and Treatment Resistant Schizophrenia: Increased Plasma Endomorphin 2, and kappa and mu Opioid Receptors Are Associated with Interleukin-6. endomorphin 2 102-115 interleukin 6 Homo sapiens 171-184 20005739-10 2010 Activation of IL-6-hsCRP pathway may play a specific role in ADHF with LVSDF. adhf 61-65 interleukin 6 Homo sapiens 14-18 33061910-6 2020 In particular, IL-6 has been involved in mediating the effects of MIA animal models in the offspring through actions on the placenta, induction of IL-17a, or triggering the decrease in non-heme iron (hypoferremia). Heme 189-193 interleukin 6 Homo sapiens 15-19 32779755-6 2020 We found that, the elevated IL-6, a risk factor in severe patients were reduced to normal level after HCQ treatment. Hydroxychloroquine 102-105 interleukin 6 Homo sapiens 28-32 19895882-11 2010 In comparison with the results for the negative control, both PU and PTFE significantly induced ROS release after 0.5h, while the expressions of TNF-alpha, IL-1beta, and IL-6 were variably increased after 24h. Polyurethanes 62-64 interleukin 6 Homo sapiens 170-174 32920000-5 2020 Our results have demonstrated that lopinavir/ritonavir increased the expression of the genes involved in immune response and lipid metabolism (IL6, ICAM1, CCL2, TNF, APOA1, etc.). lopinavir-ritonavir drug combination 35-54 interleukin 6 Homo sapiens 143-146 32920000-6 2020 Chloroquine/hydroxychloroquine + azithromycin interacted with 6 genes (CCL2, CTSB, CXCL8, IL1B, IL6 and TNF), whereas chloroquine and azithromycin affected two additional genes (BCL2L1 and CYP3A4), which might be a reason behind a greater number of consequential diseases. Chloroquine 0-11 interleukin 6 Homo sapiens 96-99 32905216-0 2020 Selenium donors inhibits osteoclastogenesis through inhibiting IL-6 and plays a pivotal role in bone metastasis from breast cancer. Selenium 0-8 interleukin 6 Homo sapiens 63-67 20391135-11 2010 Indeed, 1-methylpyrene or perylene, individually or when combined, significantly upregulated IL-1alpha and IL-6 secretion. Perylene 26-34 interleukin 6 Homo sapiens 107-111 32920000-6 2020 Chloroquine/hydroxychloroquine + azithromycin interacted with 6 genes (CCL2, CTSB, CXCL8, IL1B, IL6 and TNF), whereas chloroquine and azithromycin affected two additional genes (BCL2L1 and CYP3A4), which might be a reason behind a greater number of consequential diseases. Hydroxychloroquine 12-30 interleukin 6 Homo sapiens 96-99 32920000-6 2020 Chloroquine/hydroxychloroquine + azithromycin interacted with 6 genes (CCL2, CTSB, CXCL8, IL1B, IL6 and TNF), whereas chloroquine and azithromycin affected two additional genes (BCL2L1 and CYP3A4), which might be a reason behind a greater number of consequential diseases. Chloroquine 19-30 interleukin 6 Homo sapiens 96-99 20608029-6 2010 The author showed direct correlations between the TSH level and proinflammatory cytokines--TNFalpha, IL-6, CRP and negative correlations between HOMA IR indexes and iodinuria. Thyrotropin 50-53 interleukin 6 Homo sapiens 101-105 32920000-7 2020 In contrast to lopinavir/ritonavir, chloroquine/hydroxychloroquine + azithromycin downregulated the expression of TNF and IL6. Chloroquine 36-47 interleukin 6 Homo sapiens 122-125 32920000-7 2020 In contrast to lopinavir/ritonavir, chloroquine/hydroxychloroquine + azithromycin downregulated the expression of TNF and IL6. Hydroxychloroquine 48-66 interleukin 6 Homo sapiens 122-125 33117342-9 2020 Leonurine significantly inhibited TAZ-mediated expression of RANKL, and RANK and IL-6 in synovial fibroblasts. leonurine 0-9 interleukin 6 Homo sapiens 81-85 32618344-0 2020 Retraction: Fingolimod inhibits proliferation and epithelial- mesenchymal transition in sacral chordoma by inactivating IL-6/STAT3 signaling. Fingolimod Hydrochloride 12-22 interleukin 6 Homo sapiens 120-124 32727400-12 2020 Gene expression of the tumor-promoting cytokines and mediators, such as transforming growth factor (TGF)-beta1, vascular endothelial growth factor (VEGF), interleukin (IL)-8, and IL-6 were significantly suppressed by statins and zoledronic acid by up to 90% (p < 0.001). Zoledronic Acid 229-244 interleukin 6 Homo sapiens 179-183 20150839-12 2010 There was a nonsignificant reduction of CRP and IL-6 in the subgroup with FEV1 >50% during simvastatin treatment. Simvastatin 94-105 interleukin 6 Homo sapiens 48-52 32723256-6 2021 Additionally, HO-AAVPA reduced the number of vessels in chorioallantoid membranes (CAMs) by approximately 67.74% and IL-6 levels in both cell lines suggesting that the biochemical mechanism on cancer cell of HO-AAVPA is different compared to VPA. Valproic Acid 19-22 interleukin 6 Homo sapiens 117-121 32792945-5 2020 We performed in vitro studies using androgen-sensitive (LNCaP) and androgen-independent (LNCaP -C81) cells to investigate the anticancer effects and possible mechanisms of dioscin after administering interleukin-6 (IL-6) and dihydrotestosterone (DHT). dioscin 172-179 interleukin 6 Homo sapiens 200-213 32709035-10 2020 Conclusions: Our results suggest the presence of molecular stages of PA, defined according to the over-expression (first stage) or under-expression (second stage) of the HMOX1, SOD1, IL-6, and IFNgamma genes in abnormal skin tissue. Protactinium 69-71 interleukin 6 Homo sapiens 183-187 32726604-7 2020 RESULTS: Pre-treatment with ISL (10 or 20 muM) dose-dependently decreased the mRNA levels of TNF-alpha, IL-6, ICAM-1, and COX-2 induced by ANG II (1 mug/ml) in both MPMs and HTFs. isoliquiritigenin 28-31 interleukin 6 Homo sapiens 104-108 32589777-8 2020 The concentration of CBM (12.5%) inhibited the production of IL-6 (p<0.05), IL-8 (p<0.01) and MCP-1 (p<0.005) and augmented the production of IL-10 (p<0.05). N-(4-chlorobenzoyl)melatonin 21-24 interleukin 6 Homo sapiens 61-65 19930321-6 2009 A significantly impaired T-cell IL-10 secretion (p = 0.0001) and decreased Th function of whole T cells was found in Tacr-treated patients only, whereas unstimulated Th1 responses and SAC-I-stimulated B-cell IL-6 responses were reduced in CsA-treated patients. Tacrolimus 117-121 interleukin 6 Homo sapiens 208-212 32418114-9 2020 The levels of inflammatory cytokine IL-6 were significantly reduced from 22.2 (8.3-118.9) pg mL-1 at the beginning of the treatment to 5.2 (3.0-23.4) pg mL-1 (P<0.05) at the end of the treatment in the HCQ group but there is no change in the NHCQ group. Hydroxychloroquine 202-205 interleukin 6 Homo sapiens 36-40 32669704-7 2020 In vitro, ALA-SDT induced macrophage apoptosis and reduced TNF-alpha, IL-6 and IL-1beta via the ROS-PPARgamma-NF-kappaB signalling pathway, which indirectly inhibited human umbilical artery smooth muscle cell (HUASMC) proliferation, migration and IL-6 production. ala-sdt 10-17 interleukin 6 Homo sapiens 70-74 32669704-7 2020 In vitro, ALA-SDT induced macrophage apoptosis and reduced TNF-alpha, IL-6 and IL-1beta via the ROS-PPARgamma-NF-kappaB signalling pathway, which indirectly inhibited human umbilical artery smooth muscle cell (HUASMC) proliferation, migration and IL-6 production. ala-sdt 10-17 interleukin 6 Homo sapiens 247-251 19647484-7 2009 CONCLUSIONS: p38 MAPK inhibition with SD-282 decreases the pro-inflammatory response as represented by lower IL-6 and TNFalpha in plasma and lungs following brain death. indole-5-carboxamide 38-44 interleukin 6 Homo sapiens 109-113 31887416-10 2020 RESULTS: IL-6 levels increased after treatment only in the group of children who developed FLX-associated suicidality. Fluoxetine 91-94 interleukin 6 Homo sapiens 9-13 31887416-11 2020 CONCLUSION: An increase in IL-6 levels during treatment may be a risk factor for the emergence of FLX-associated suicidality (OR=1.70). Fluoxetine 98-101 interleukin 6 Homo sapiens 27-31 33062720-2 2020 CQ and HCQ are able to inhibit the production of cytokines such as interleukin- (IL-) 1, IL-2, IL-6, IL-17, and IL-22. Chloroquine 0-2 interleukin 6 Homo sapiens 95-99 33062720-2 2020 CQ and HCQ are able to inhibit the production of cytokines such as interleukin- (IL-) 1, IL-2, IL-6, IL-17, and IL-22. Hydroxychloroquine 7-10 interleukin 6 Homo sapiens 95-99 19908944-0 2009 The cannabinoid R+ methanandamide induces IL-6 secretion by prostate cancer PC3 cells. Cannabinoids 4-15 interleukin 6 Homo sapiens 42-46 32843372-9 2020 Among secondary end points, the Theranova 400 group demonstrated significantly larger reduction ratios at 4 and 24 weeks for complement factor D, free kappa light chains, TNFalpha, and beta2-microglobulin (P<0.001 for all), but not for IL-6. theranova 400 32-45 interleukin 6 Homo sapiens 236-240 31789949-7 2020 RESULTS: 25(OH)D levels were inversely correlated with CP score, MELD, IL-6, and CP stage and VDBP levels with CP score, MELD, IL-6, IL-8, LBP, and CP stage. 25-hydroxyvitamin D3-bromoacetate 9-16 interleukin 6 Homo sapiens 71-75 19525101-8 2009 Interestingly, aminophylline and terbutaline could not only down-regulate the ingestion of apoptotic eosinophils by A549 cells in a time- and dose-dependent manner, but also decrease IL-6 and IL-8 secretion by A549 cells induced by LPS. Aminophylline 15-28 interleukin 6 Homo sapiens 183-187 20077945-8 2009 CRP, IL-6 and conjugated dienes correlated with BMI, while IL-6 and conjugated dienes correlated inversely with carotenoids (P < 0.05). Carotenoids 112-123 interleukin 6 Homo sapiens 59-63 32579203-0 2020 Expression of Concern: Fingolimod inhibits proliferation and epithelial-mesenchymal transition in sacral chordoma by inactivating IL-6/STAT3 signaling. Fingolimod Hydrochloride 23-33 interleukin 6 Homo sapiens 130-134 32554275-9 2020 Toxicological results revealed that indoor and personal exposure to OC as well as PAH compounds and their derivatives (e.g., Alkyl-PAHs, Oxy-PAHs) induced cell viability reduction and increase in levels of LDH, IL-6, and 8-isoprostane. oc 68-70 interleukin 6 Homo sapiens 211-215 32554275-11 2020 Subsequently, we examined the associations of FeNO with IL-6 and 8-isoprostane levels using mixed-effects models. feno 46-50 interleukin 6 Homo sapiens 56-60 32554275-12 2020 The results showed that per interquartile change in IL-6 and 8-isoprostane were associated with a 6.4% (p < 0.01) and 11.1% (p < 0.01) increase in FeNO levels, respectively. feno 147-151 interleukin 6 Homo sapiens 52-56 19155534-9 2009 The PPAR-gamma antagonist, GW9662, significantly attenuated the inhibitory action of rosiglitazone on the increased synthesis of IL-6 and ATR1 protein. 2-chloro-5-nitrobenzanilide 27-33 interleukin 6 Homo sapiens 129-133 32655793-8 2020 Moreover, fingolimod suppressed the secretion of pro-inflammatory or inflammatory cytokines IL-17A, IL-6, and INF-gamma, but did not noticeably alter the secretion of immunosuppressive cytokines TGF-beta1 and IL-4. Fingolimod Hydrochloride 10-20 interleukin 6 Homo sapiens 100-104 19342597-0 2009 CREB-mediated IL-6 expression is required for 15(S)-hydroxyeicosatetraenoic acid-induced vascular smooth muscle cell migration. Hydroxyeicosatetraenoic Acids 48-80 interleukin 6 Homo sapiens 14-18 32373498-8 2020 Results: After 3 weeks, treatment of patients with ALA led to a significant decrease in tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) levels (P=0.01) compared to baseline. Thioctic Acid 51-54 interleukin 6 Homo sapiens 132-145 32584515-7 2020 In addition, periplocin decreased the TNF-alpha-induced mRNA and protein expression levels of interleukin (IL)-1beta and IL-6 in RA-FLSs in a dose-dependent way. periplocin 13-23 interleukin 6 Homo sapiens 121-125 32841225-7 2020 Dioscin suppressed TLR4/NF-0kappaB signaling, and attenuated the level of inflammatory mediators (IL-6, TNF-alpha) in IL-1ss-stimulated human NP cells. dioscin 0-7 interleukin 6 Homo sapiens 98-102 32373498-8 2020 Results: After 3 weeks, treatment of patients with ALA led to a significant decrease in tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) levels (P=0.01) compared to baseline. Thioctic Acid 51-54 interleukin 6 Homo sapiens 147-151 19342597-7 2009 15(S)-HETE induced expression and secretion of interleukin-6 (IL-6), as analyzed by RT-PCR and ELISA, respectively. Hydroxyeicosatetraenoic Acids 6-10 interleukin 6 Homo sapiens 47-60 19342597-7 2009 15(S)-HETE induced expression and secretion of interleukin-6 (IL-6), as analyzed by RT-PCR and ELISA, respectively. Hydroxyeicosatetraenoic Acids 6-10 interleukin 6 Homo sapiens 62-66 32903465-10 2020 Furthermore, isoquercitrin treatment reduced the levels of inflammatory factors-interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha (TNF-alpha)-in the target muscle and inactivated the JAK/STAT3 signaling pathway. isoquercitrin 13-26 interleukin 6 Homo sapiens 104-108 19342597-8 2009 Neutralizing anti-IL-6 antibodies blocked 15(S)-HETE-induced VSMC migration. Hydroxyeicosatetraenoic Acids 48-52 interleukin 6 Homo sapiens 18-22 31840936-12 2020 Metformin or AICAR presence decreased spontaneous production of IL-6, IL-8 and MCP-1 in RA synovial explants and SFCs (n=5-7). AICA ribonucleotide 13-18 interleukin 6 Homo sapiens 64-68 19342597-9 2009 Dominant-negative mutant-mediated blockade of ERK1/2, JNK1, p38MAPK, or CREB suppressed 15(S)-HETE-induced IL-6 expression in VSMCs. Hydroxyeicosatetraenoic Acids 94-98 interleukin 6 Homo sapiens 107-111 32450500-5 2020 Treatment of these M2 macrophages with BC led to suppression of M2-type macrophage-associated markers and of the IL-6/STAT3 signaling pathway. beta Carotene 39-41 interleukin 6 Homo sapiens 113-117 31584241-6 2020 RESULTS: In vitro and ex vivo studies clearly demonstrated that diglucosyl gallic acid (active A) and the formulation complex inhibited pollution mediated MMP1 protein, CYP1A1 gene expression, and IL-6 protein secretion, while caprylic/capric triglyceride, diacetyl boldine (active B) had anti-melanogenic effect in in vitro primary melanocyte monoculture and 3D spheroid model. Gallic Acid 64-86 interleukin 6 Homo sapiens 197-201 19416633-6 2009 Resveratrol significantly inhibited the PMA plus A23187-induction of inflammatory cytokines such as tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-8. Calcimycin 49-55 interleukin 6 Homo sapiens 136-154 32523550-7 2020 In line with the supposed switch to a pro-inflammatory phenotype known as the senescence associated secretory phenotype (SASP), we found that both RS and DS upregulated IL-1beta and released HMGB-1 from the nucleus, while RS also showed IL-6 upregulation. ds 154-156 interleukin 6 Homo sapiens 237-241 32632100-5 2020 Interestingly, PI3KalphaH1047R ducts also elicit increased permeability and structural disorganization of the endothelium, and we identify the distinct secretion of IL-6 as the paracrine cause of PI3KalphaH1047R-associated vascular dysfunction. pi3kalphah1047r 196-211 interleukin 6 Homo sapiens 165-169 19181383-7 2009 In contrast, an inhibitor of both IRAK-1 and IRAK-4 (RO0884) reduced IL-1beta induced p38 MAP kinase, c-Jun N-terminal kinase activation, and IL-6 production in HUVEC. ro0884 53-59 interleukin 6 Homo sapiens 142-146 32413408-0 2020 Hydroxychloroquine reduces IL-6 and pro-thrombotic status. Hydroxychloroquine 0-18 interleukin 6 Homo sapiens 27-31 32523801-12 2020 Conclusion: CAR T-derived IL-6 is one of the most important initiators to amplify release of IL-6 from monocytes that further drive sCRS development. 2,6-DIISOPROPYLNAPHTHALENE 74-81 interleukin 6 Homo sapiens 26-30 32523801-12 2020 Conclusion: CAR T-derived IL-6 is one of the most important initiators to amplify release of IL-6 from monocytes that further drive sCRS development. 2,6-DIISOPROPYLNAPHTHALENE 74-81 interleukin 6 Homo sapiens 93-97 32348149-3 2020 Benefiting from multi-enzyme activities against RONS, Rh-PEG NDs can decrease the levels of pro-inflammatory cytokines (TNF-alpha, IL-6), resulting in good anti-inflammatory effect on dextran sulfate sodium-induced colitis. rh-peg nds 54-64 interleukin 6 Homo sapiens 131-135 19248856-9 2009 Serum interleukin-6 was inversely associated with intakes of legumes, vegetables, beta carotene, and vitamin C. Ascorbic Acid 101-110 interleukin 6 Homo sapiens 6-19 31939864-7 2020 Higher selenium, but not chromium or zinc, was associated with lower IL6, sTNFRI and II and higher beta d glucan, a marker of fungal translocation, zonulin, a marker of gut permeability, oxidized LDL and insulin resistance (p<=0.01).In this cohort of PHIV on ART in Uganda, there is a high prevalence of low zinc status overall. Selenium 7-15 interleukin 6 Homo sapiens 69-72 32301466-6 2020 The interaction of interleukin 6 with the antibodies produces a blue-shift in resonant wavelength and the reflectance intensity increases up to 50% and 44% when tested with CoF & magnetite based MPC respectively at a concentration of 50 pg ml-1. 2-methacryloyloxyethyl phosphorylcholine 195-198 interleukin 6 Homo sapiens 19-32 31222631-7 2020 RESULTS: After covarying for age, gender, body mass index, chronic pain status, salivary flow rate, and NA, higher PA was associated with lower salivary CRP (beta = - 0.02, 95% CI (- 0.03, - 0.00) sr2 = .06, p = .01) but not IL-6; removing NA from this model did not change results. Protactinium 115-117 interleukin 6 Homo sapiens 225-229 19142153-3 2009 Agents in late-stage clinical trials include golimumab and certolizumab, which are anti-tumor necrosis factor (TNF)-alpha agents; ocrelizumab, an anti-CD20 agent; and tocilizumab, an inhibitor of interleukin-6. Certolizumab Pegol 59-71 interleukin 6 Homo sapiens 196-209 31833613-8 2020 Diosmetin treatment resulted in an increase in apoptotic rates and a reduction in TNF-alpha-induced production of IL-1beta, IL-6, IL-8, and MMP-1 in MH7A cells. diosmetin 0-9 interleukin 6 Homo sapiens 124-128 32292576-6 2020 Injection of Mobilan induced signs of self-resolving inflammation not present in placebo-injected patients, including transient elevation of PSA and cytokine (G-CSF, IL-6) levels, and increased lymphoid infiltration in prostate tissue. Indomethacin 13-20 interleukin 6 Homo sapiens 166-170 19136878-9 2009 White blood cells and IL-6 might be involved in inflammatory process of zinc fume exposure with zinc and copper increasing GSH, but nickel depleting it. Nickel 132-138 interleukin 6 Homo sapiens 22-26 32264730-0 2020 Treatment with 7% and 10% CO2 enhanced expression of IL-1beta, TNF-alpha, and IL-6 in hypoxic cultures of human whole blood. Carbon Dioxide 26-29 interleukin 6 Homo sapiens 78-82 32049375-7 2020 The MCI/MI- or MI- induced secretion of IL-1beta, TNF and IL-6 by PBMC was analysed by flow cytometry. mci 4-7 interleukin 6 Homo sapiens 58-62 32049375-8 2020 RESULTS: The results showed a decreased TLR4 expression with upregulated IL6, FOXP3, IL10 and TGFbeta mRNA expression as assessed by q-PCR at the site of the MCI/MI skin reaction. mci 158-161 interleukin 6 Homo sapiens 73-76 18474668-7 2008 Exposure to gamma-iE-DAP at the apical surface of differentiated, polarized cultures resulted in activation of the innate immune response in an NOD1- and RIP2-dependent manner, resulting in release of IL-6 and IL-8. N(2)-(gamma-D-glutamyl)-meso-2,2'-diaminopimelic acid 12-24 interleukin 6 Homo sapiens 201-205 32411755-9 2020 Results: In this study, we found that pre-treatment with wogonoside dramatically suppressed lipopolysaccharide (LPS)-induced increase in the protein and mRNA levels of inflammatory factors in macrophages, such as cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, and IL-6. wogonoside 57-67 interleukin 6 Homo sapiens 342-346 32411755-13 2020 Additionally, ChIP analysis demonstrated wogonoside to remarkably reduce c-Jun enrichment in COX-2, iNOS, IL-1beta, TNF-alpha, and IL-6 promoters. wogonoside 41-51 interleukin 6 Homo sapiens 131-135 32135490-8 2020 Pristimerin dramatically inhibited the expression of TNF-alpha-induced endothelial adhesion molecules (intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1)) and the pro-inflammatory cytokine (IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1)). pristimerin 0-11 interleukin 6 Homo sapiens 229-233 32015511-7 2020 Nintedanib greatly reduced the levels of cancer-promoting cytokines, such as interleukin (IL)-6 (IL-6) and IL-8, secreted by CAFs. nintedanib 0-10 interleukin 6 Homo sapiens 97-101 18710929-8 2008 Finally, adoptive transfer of IL-6 and wild-type T cells demonstrated that oxazolone colitis is critically dependent on IL-6 production by T cells. Oxazolone 75-84 interleukin 6 Homo sapiens 30-34 31790890-11 2020 A significant difference in nicotinamide adenine dinucleotide phosphate oxidase 2 concentrations was observed between T0 and T2 only in ADPKD patients treated with ALA (P = 0.039, P = 0.039; respectively), although we did not find a significant difference in interleukin-6, interleukin -1beta, and tumor necrosis factor-alpha concentrations in either group. Thioctic Acid 164-167 interleukin 6 Homo sapiens 259-272 32256731-3 2020 NSCLC cell epithelial-mesenchymal transition (EMT), metastasis and migration were distinctly controlled in vitro by miR-449b-3p, that was found to directly target interleukin (IL)-6. mir-449b-3p 116-127 interleukin 6 Homo sapiens 163-181 32535571-8 2020 Increased concentrations of catecholamines are associated with increased blood levels of proinflammatory cytokines such as IL-6 and TNF-b.the level of CRP may reflect the inflammatory process in the intima of blood vessels. Catecholamines 28-42 interleukin 6 Homo sapiens 123-127 32216836-16 2020 The treatment of cells with HCQ increased the levels of TNF-alpha and IL-6 compared to the Met-treated cells. Hydroxychloroquine 28-31 interleukin 6 Homo sapiens 70-74 32214297-12 2020 A significant decrease of interleukin (IL)-1 beta, IL-6, tumor necrosis factor (TNF)-alpha, and increased CD4+ and CD4+/CD8+ were observed in the DEX group compared with the SUF group at 24 and 48 hours after surgery (P < 0.05). Dextromethorphan 146-149 interleukin 6 Homo sapiens 51-55 18710929-8 2008 Finally, adoptive transfer of IL-6 and wild-type T cells demonstrated that oxazolone colitis is critically dependent on IL-6 production by T cells. Oxazolone 75-84 interleukin 6 Homo sapiens 120-124 18698233-5 2008 METHODS AND RESULTS: In cells expressing the 299D-399T TLR4, LPS activated the transcription factor NFkappaB and increased the expression of interleukin-6 and tumor necrosis factor-alpha, and these effects were reduced by pretreatment of the cells with pravastatin or simvastatin. Simvastatin 268-279 interleukin 6 Homo sapiens 141-186 31698296-11 2020 An inverse correlation between serum selenium concentration and several proinflammatory cytokines (interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha) was found. Selenium 37-45 interleukin 6 Homo sapiens 118-131 32265833-6 2020 In turn, TB+DM showed even higher levels of interferon gamma -IFN-gamma- and hGH (vs. TB), or IL-6, C reactive protein, cortisol and hGH (vs. DM). Terbium 9-11 interleukin 6 Homo sapiens 94-98 18514331-4 2008 Similarly, proliferation and IL6 production of B blasts stimulated with low dose lipopolysaccharide (LPS) or CpG oligodeoxynucleotide 1826 were also dramatically inhibited by platelets. cpg oligodeoxynucleotide 1826 109-138 interleukin 6 Homo sapiens 29-32 31648047-5 2020 We found that rifampicin pretreatment suppressed the gene expression of IL-1beta and IL-6 via inhibiting activation of JNK after rotenone induction, but the anti-inflammatory effect of rifampicin was reversed by chloroquine. Rotenone 129-137 interleukin 6 Homo sapiens 85-89 32089648-0 2020 CD154 Induces Interleukin-6 Secretion by Kidney Tubular Epithelial Cells under Hypoxic Conditions: Inhibition by Chloroquine. Chloroquine 113-124 interleukin 6 Homo sapiens 14-27 32089648-7 2020 Searching for inhibitors of CD154-mediated IL-6 production by HK-2 cells in hypoxic conditions, we observed that chloroquine, a drug that has been repurposed as an anti-inflammatory agent, alleviated this induction. Chloroquine 113-124 interleukin 6 Homo sapiens 43-47 32089648-9 2020 The inhibition of CD154-induced IL-6 production by chloroquine suggests the potential usefulness of this drug as a therapeutic adjunct in conditions associated with acute kidney injury. Chloroquine 51-62 interleukin 6 Homo sapiens 32-36 32017913-6 2020 Additionally, Phoenixin-20 suppressed LPS-induced release of pro-inflammatory cytokines and inflammatory mediators, including IL-6, MCP-1, VCAM-1, and ICAM-1, as well as MMP-2 and MMP-9. phoenixin-20 14-26 interleukin 6 Homo sapiens 126-130 18498042-4 2008 We found that TET decreased the release of NO, TNF-alpha, IL-6 and IL-1beta in LPS-activated astrocytes. tet 14-17 interleukin 6 Homo sapiens 58-62 31448433-2 2020 This study characterizes the relationships between upadacitinib exposure and interleukin (IL)-6-induced signal transducer and activator of transcription proteins 3 (STAT3) phosphorylation (pSTAT3) and IL-7-induced STAT5 phosphorylation (pSTAT5) in the ex vivo setting as measures for JAK1 and JAK1/JAK3 inhibition, respectively, with comparison to tofacitinib. upadacitinib 51-63 interleukin 6 Homo sapiens 77-95 31963848-5 2020 Thus, in this paper, we report a simple synergistic integration of the cell trapping of microwell chip and gold-capped nanopillar-structured cyclo-olefin-polymer (COP) film for single cell level Interleukin 6 (IL-6) detection. Alkenes 141-153 interleukin 6 Homo sapiens 195-208 31963848-5 2020 Thus, in this paper, we report a simple synergistic integration of the cell trapping of microwell chip and gold-capped nanopillar-structured cyclo-olefin-polymer (COP) film for single cell level Interleukin 6 (IL-6) detection. Alkenes 141-153 interleukin 6 Homo sapiens 210-214 31678878-8 2020 Blood Pb levels were negatively correlated with salivary sialic acids, in which IL-6 played as a mediator of the association between blood Pb levels and saliva sialic acid concentrations according to the mediation model. Lead 139-141 interleukin 6 Homo sapiens 80-84 18471882-4 2008 Here we show that in contrast with PI3Kalpha, beta and gamma, PI3Kdelta accounts for most of the PI3K-dependent signaling ruling the production of IL-1beta, IL-6, TNF and sIL-1Ra in monocytes activated by cellular contact with stimulated T cells (mimicked by CHAPS-solubilized membranes of stimulated T cells, CE sHUT) and lipopolysaccharides (LPS); the latter stimuli being relevant to chronic/sterile and acute/infectious inflammation, respectively. 3-((3-cholamidopropyl)dimethylammonium)-1-propanesulfonate 259-264 interleukin 6 Homo sapiens 157-161 33268707-5 2020 Moreover, baicalein suppressed the production of interleukin (IL)-6 and the metastatic potential of breast cancer cells both in vitro and in vivo. baicalein 10-19 interleukin 6 Homo sapiens 49-67 31610043-11 2020 RESULTS: We have found that the stimulation of arecoline on FBs increased interleukin-2, interleukin-6, and interleukin-21 (IL-2, IL-6, and IL-21) while decreased transforming growth cytokine-beta (TGF-beta). Arecoline 47-56 interleukin 6 Homo sapiens 89-102 31610043-11 2020 RESULTS: We have found that the stimulation of arecoline on FBs increased interleukin-2, interleukin-6, and interleukin-21 (IL-2, IL-6, and IL-21) while decreased transforming growth cytokine-beta (TGF-beta). Arecoline 47-56 interleukin 6 Homo sapiens 130-134 18574092-10 2008 Low 25-hydroxyvitamin D levels were significantly correlated with variables of inflammation (C-reactive protein and interleukin 6 levels), oxidative burden (serum phospholipid and glutathione levels), and cell adhesion (vascular cell adhesion molecule 1 and intercellular adhesion molecule 1 levels). 25-hydroxyvitamin D 4-23 interleukin 6 Homo sapiens 116-129 31672627-5 2020 RESULTS: We stratified control and T2DM groups by 25(OH)D concentration and it indicates that in severe deficiency and sufficiency category IL-6, IL-1beta, TNF-alpha, and Ox-LDL were significantly different while in moderate deficiency category only MDA was significantly different, among control and T2DM groups. 25-hydroxyvitamin D3-bromoacetate 50-57 interleukin 6 Homo sapiens 140-144 31672627-7 2020 Correlation analysis indicates a negative correlation of 25(OH)D with IL-6, IL-1beta, TNF-alpha, and Ox-LDL among total subjects. 25-hydroxyvitamin D3-bromoacetate 57-64 interleukin 6 Homo sapiens 70-74 31672627-8 2020 Further, logistics regression analysis demonstrated a significant association of different categories of 25(OH)D with IL-6, IL-1beta, TNF-alpha, and Ox-LDL before and after adjustment to body mass index and waist to hip ratio. 25-hydroxyvitamin D3-bromoacetate 105-112 interleukin 6 Homo sapiens 118-122 31711766-0 2020 Corrigendum to "Synthesis and biological evaluation of tetrazole derivatives as TNF-alpha, IL-6 and COX-2 inhibitors with antimicrobial activity: Computational analysis, molecular modeling study and region-specific cyclization using 2D NMR tools" [Bioorg. Tetrazoles 55-64 interleukin 6 Homo sapiens 91-95 32203973-9 2020 Further analysis showed that 10 days of SB pretreatment not only prevented LPS-induced increases in proinflammatory cytokines, such as interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha, in the hippocampus and prefrontal cortex but also prevented LPS-induced enhancement of oxido-nitrosative stress. Butyric Acid 40-42 interleukin 6 Homo sapiens 159-163 32844633-0 2020 [The influence of fluoxetine on interleukin-6 and interleukin-1beta production by dendritic cells in multiple sclerosis in vitro]. Fluoxetine 18-28 interleukin 6 Homo sapiens 32-45 32844633-1 2020 THE AIM OF THE STUDY: Was to evaluate the effect of selective serotonin reuptake inhibitor fluoxetine on the production of cytokines interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) by dendritic cells in multiple sclerosis (MS). Fluoxetine 91-101 interleukin 6 Homo sapiens 133-146 32844633-1 2020 THE AIM OF THE STUDY: Was to evaluate the effect of selective serotonin reuptake inhibitor fluoxetine on the production of cytokines interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) by dendritic cells in multiple sclerosis (MS). Fluoxetine 91-101 interleukin 6 Homo sapiens 148-152 32844633-6 2020 Fluoxetine suppressed IL-6 and IL-1beta production in both groups. Fluoxetine 0-10 interleukin 6 Homo sapiens 22-26 32844633-8 2020 In contrast, activation of 5-HT2B-receptors by specific agonist BW 723C86 increased the inhibitory effect of fluoxetine on IL-6 production by dendritic cells in both groups, but did not affect on IL-1beta production. Fluoxetine 109-119 interleukin 6 Homo sapiens 123-127 31707338-3 2020 Trichomicin can significantly induce cancer cell apoptosis and reduced IL-6 expression and phosphorylation of STAT3 were found in response to Trichomicin treatment. trichomicin 0-11 interleukin 6 Homo sapiens 71-75 31707338-3 2020 Trichomicin can significantly induce cancer cell apoptosis and reduced IL-6 expression and phosphorylation of STAT3 were found in response to Trichomicin treatment. trichomicin 142-153 interleukin 6 Homo sapiens 71-75 31707338-4 2020 The blockade of IL-6 mediated JAK-STAT3 signaling pathway by Trichomicin was confirmed using reporter gene system. trichomicin 61-72 interleukin 6 Homo sapiens 16-20 18457971-9 2008 Treatment with the COX-2 inhibitor (NS-398) or COX-2 antisense oligonucleotides also diminished IL-1beta and IL-6 release. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 36-42 interleukin 6 Homo sapiens 109-113 31472402-4 2020 TB-KDM individuals exhibit significantly higher levels of IFNgamma, IL-2, TNFalpha, IL-17A, IL-1alpha, IL-1beta and IL-6 in comparison to TB-NDM, TB alone and DM alone individuals. Terbium 0-2 interleukin 6 Homo sapiens 116-120 31472402-7 2020 TB-NDM individuals are also characterized by significantly diminished TB-antigen stimulated levels of IFNgamma, IL-2, TNFalpha, IL-17A, IL-17F, IL-1alpha, IL-1beta and/or IL-6 at pre-treatment and at 2 months of ATT and IFNgamma, IL-2, IL-1alpha and IL-1beta at post-treatment. Terbium 0-2 interleukin 6 Homo sapiens 171-175 31931639-4 2020 Dioscin (20, 40, and 80 mg/kg) was administered intragastrically once daily for seven consecutive days prior to LPS challenge.Results:Our data revealed that dioscin significantly suppressed LPS-induced lung pathological changes, pulmonary capillary permeability, pulmonary edema, inflammatory cell infiltration, myeloperoxidase (MPO) activity, and cytokine production, including tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and keratinocyte chemoattractant (KC). dioscin 157-164 interleukin 6 Homo sapiens 414-432 31792230-6 2019 Additionally, malaria pathogenicity genes (thrombospondin 1-(THBS 1), interleukin 6 (IL6), and arginine decarboxylase 2 (ADC2)) were down-regulated. Arginine Vasopressin 95-103 interleukin 6 Homo sapiens 70-83 31468982-7 2019 The results showed that juglanin dose-dependently suppressed PGE2, NO, MMP-1, MMP3, MMP13, TNF-alpha and IL-6 production induced by IL-1beta. juglanin 24-32 interleukin 6 Homo sapiens 105-109 18040689-4 2008 Results of experiments presented here indicate that addition of AjA (3-30 microM) to human monocyte derived macrophages in vitro reduces steady state levels of IL-6 mRNA and the subsequent secretion of IL-6 from LPS stimulated cells. lenabasum 64-67 interleukin 6 Homo sapiens 160-164 31733650-7 2019 The neurotoxic effects of PPA was clearly presented as much higher IL-6, as pro-inflammatory cytokine (P<0.05), concomitant with much lower IL-10, as anti-inflammatory cytokine(P<0.015) compared to controls. propionic acid 26-29 interleukin 6 Homo sapiens 67-71 31733650-8 2019 Both bee pollen and propolis were effective in ameliorating the neurotoxic effects of PPA demonstrating non-significant changes of IL-6 and IL-10 when compared to control healthy hamsters. propionic acid 86-89 interleukin 6 Homo sapiens 131-135 31817563-3 2019 We find that the pretreatment with non-cytotoxic concentrations (0.5-1 mug/ml of gallic acid equivalent) of LPE inhibits interleukin-6 (IL-6)-induced cell migration and invasiveness in MKN-28 and AGS cells, as analyzed by wound and matrigel assays. Gallic Acid 81-92 interleukin 6 Homo sapiens 121-134 31817563-3 2019 We find that the pretreatment with non-cytotoxic concentrations (0.5-1 mug/ml of gallic acid equivalent) of LPE inhibits interleukin-6 (IL-6)-induced cell migration and invasiveness in MKN-28 and AGS cells, as analyzed by wound and matrigel assays. Gallic Acid 81-92 interleukin 6 Homo sapiens 136-140 18040689-4 2008 Results of experiments presented here indicate that addition of AjA (3-30 microM) to human monocyte derived macrophages in vitro reduces steady state levels of IL-6 mRNA and the subsequent secretion of IL-6 from LPS stimulated cells. lenabasum 64-67 interleukin 6 Homo sapiens 202-206 18844117-4 2008 4% formaldehyde was used to fix the FLS and LAD-2 cells and then detect the IL-6 levels in the supernatant. Formaldehyde 3-15 interleukin 6 Homo sapiens 76-80 31624951-9 2019 RESULTS: The main effect of condition was detected for IL-6 (SUP: 1.36 +- 0.66 vs CON: 2.06 +- 1.14 pg/ml) (P < 0.05, eta2 = 0.54), sIL-6R (SUP: 27,615 +- 8446 vs CON: 24,368 +- 7806 pg/ml) (P < 0.05, eta2 = 0.41) and muscle soreness (P < 0.01, eta2 = 0.67). suprofen-copper(II) complex 61-64 interleukin 6 Homo sapiens 55-59 31624951-9 2019 RESULTS: The main effect of condition was detected for IL-6 (SUP: 1.36 +- 0.66 vs CON: 2.06 +- 1.14 pg/ml) (P < 0.05, eta2 = 0.54), sIL-6R (SUP: 27,615 +- 8446 vs CON: 24,368 +- 7806 pg/ml) (P < 0.05, eta2 = 0.41) and muscle soreness (P < 0.01, eta2 = 0.67). suprofen-copper(II) complex 143-146 interleukin 6 Homo sapiens 55-59 31343124-5 2019 In CXA-10-202, a consistent decrease from baseline was observed with CXA-10 150 mg dose, but not 25 or 450 mg doses, for biomarkers of altered inflammation and metabolic dysfunction, including leptin, triglycerides, cholesterol, MCP-1, and IL-6. 10-nitro-oleic acid 3-9 interleukin 6 Homo sapiens 240-244 31343124-5 2019 In CXA-10-202, a consistent decrease from baseline was observed with CXA-10 150 mg dose, but not 25 or 450 mg doses, for biomarkers of altered inflammation and metabolic dysfunction, including leptin, triglycerides, cholesterol, MCP-1, and IL-6. 10-nitro-oleic acid 69-75 interleukin 6 Homo sapiens 240-244 17709599-6 2008 Inhibition of cyclooxygenase (Cox)-2 with NS-398 was associated with reductions in Cox-2 (2-fold) and IL-6 (1.3-fold) mRNA transcripts, and in IL-8 and PGE-2 chemokine secretion. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 42-48 interleukin 6 Homo sapiens 102-106 31364019-11 2019 In conclusion, increasing levels of Se and Zn decreases the intensity of inflammation as measured by IL-6, IL-10 and TNF-alpha levels. Selenium 36-38 interleukin 6 Homo sapiens 101-105 31686824-2 2019 Aim: The present study investigated associations between plasma IL-6 and plasma catecholamine metabolites in patients with MDD. Catecholamines 80-93 interleukin 6 Homo sapiens 64-68 32029037-8 2019 Compared with the LPS group, the oxidative activities and inflammatory factors above were inhibited in EP group [MDA (mumol/L): 12.35+-2.21 vs. 45.95+-1.76, SOD (kU/L): 54.68+-1.42 vs. 40.73+-1.60, IL-6 (ng/L): 67.87+-2.61 vs. 338.92+-20.91, TNF-alpha (ng/L): 19.23+-1.80 vs. 180.69+-6.51], mitochondrial membrane potential and ATP level were significantly increased [mitochondrial membrane potential: (99.43+-0.25)% vs. (69.40+-0.75)%, ATP (x106 RLU): 0.19+-0.01 vs. 0.12+-0.05], the expression of mitochondrial fission protein was significantly decreased (DAPK-2/beta-actin: 0.03+-0.01 vs. 0.61+-0.02), mitochondrial fusion proteins were significantly increased (Mfn-1/beta-actin: 0.43+-0.04 vs. 0.17+-0.01, Mfn-2/beta-actin: 0.201+-0.004 vs. 0.001+-0.001), percentage of cell apoptosis was significantly decreased [(5.25+-0.17)% vs. (34.42+-0.64)%], the expressions of apoptotic proteins were significantly decreased (caspase-3/beta-actin: 0.25+-0.15 vs. 1.76+-0.01, caspase-9/beta-actin: 0.09+-0.02 vs. 1.52+-0.12, Cyt C/beta-actin: 0.001+-0.001 vs. 0.350+-0.030), and the expressions of anti-apoptotic proteins and PARP were significantly increased (Bcl-2/beta-actin: 0.500+-0.010 vs. 0.009+-0.004, Bcl-xL/beta-actin: 0.550+-0.010 vs. 0.009+-0.001, PARP/beta-actin: 0.94+-0.01 vs. 0.16+-0.13), with statistically significant differences (all P < 0.05). ethyl pyruvate 103-105 interleukin 6 Homo sapiens 198-202 31885820-9 2019 Moreover, alpha-LA has mechanisms of epigenetic regulation in genes related to the expression of various inflammatory mediators, such PGE2, COX-2, iNOS, TNF-alpha, IL-1beta, and IL-6. Thioctic Acid 10-18 interleukin 6 Homo sapiens 178-182 31228705-4 2019 Owing to the ROS scavenging ability of quercetin, Qu-FeIIP effectively reduces intracellular ROS and in vivo inflammatory factors (TNF-alpha, IL-6, IFN-gamma) levels. qu-feiip 50-58 interleukin 6 Homo sapiens 142-146 31827715-0 2019 Hydrostatin-SN10 Ameliorates Pancreatitis-Induced Lung Injury by Affecting IL-6-Induced JAK2/STAT3-Associated Inflammation and Oxidative Stress. hydrostatin 0-11 interleukin 6 Homo sapiens 75-79 18991693-3 2008 Following red wine (Negroamaro) pretreatment of lymphomonocytes, results will show a production of regulatory [Interleukin(IL)-12], proinflammatory (IL-1 beta and IL-6), and anti-inflammatory (IL-10) cytokines, as well as of IgA and IgG. red wine 10-18 interleukin 6 Homo sapiens 163-167 31827715-8 2019 Hydrostatin-SN10 significantly inhibited the IL-6-stimulated JAK2/STAT3 pathway and reduced the number of apoptotic cells via the downregulation of caspase 3 and BAX (proapoptotic) and upregulation of Bcl2 (antiapoptotic) (p < 0.05). hydrostatin 0-11 interleukin 6 Homo sapiens 45-49 31827715-9 2019 IL-6 induced the increase in the levels of JAK2 and STAT3, which was reversed by hydrostatin-SN10 treatment (p < 0.05). hydrostatin 81-92 interleukin 6 Homo sapiens 0-4 31827715-10 2019 In addition, hydrostatin-SN10 reduced the expression of IL-6 and TNF- (tumor necrosis factor-) alpha and increased the level of IL-10 (p < 0.05). hydrostatin 13-24 interleukin 6 Homo sapiens 56-100 31827715-12 2019 These results suggest that hydrostatin-SN10 may inhibit pancreatitis-induced acute lung injury by affecting IL-6-mediated JAK2/STAT3 pathway-associated inflammation and oxidative stress. hydrostatin 27-38 interleukin 6 Homo sapiens 108-112 31464310-4 2019 In the present study, we identified that cyanidin treatment could strongly suppress the expression of NO, PGE2, TNF-alpha, IL-6, iNOs, COX-2, ADAMTS5 and MMP13, and reduce the degradation of aggrecan and collagen II in IL-1beta-induced human OA chondrocytes, indicating the anti-inflammatory effect of cyanidin. cyanidin 41-49 interleukin 6 Homo sapiens 123-127 31375659-8 2019 Response to paroxetine treatment correlated with baseline IL-10, IL-6 and TNF-alpha levels, with the strongest signal being observed in males. Paroxetine 12-22 interleukin 6 Homo sapiens 65-69 19143193-9 2008 RESULTS: A dominating hyperactivation of cytokines TNFalpha, IL-1alpha, IL-2, IL-6 with high expression of CIC and autoAB to CL was associated with moderate or severe CCF (FCII-IV by NYHA), declined inotropic function of the left ventricle (EF 38-23%), low exercise tolerance and remodeling of the left ventricle. cic 107-110 interleukin 6 Homo sapiens 78-82 30848409-0 2019 Heteroleptic Ruthenium Polypyridyl Complex Had Differential Effects on the Production of Pro-inflammatory Cytokines TNFalpha, IL1beta, and IL6 by the Mammalian Macrophages In Vitro. ruthenium polypyridyl complex 13-42 interleukin 6 Homo sapiens 139-142 31814911-9 2019 Compared with S15 and S0 groups, the protein expressions of TNF-alpha and IL-6 in placental trophoblast cells of S60 and S30 groups also showed an significant increase (P<0.05). fullerene C60 113-116 interleukin 6 Homo sapiens 74-78 31553934-7 2019 CBDV attenuates, in a TRPA1-antagonist sensitive manner, DNBS-induced signs of inflammation including neutrophil infiltration, intestinal permeability, and cytokine (i.e. IL-1beta, IL-6 and the chemokine MCP-1) production. cannabidivarin 0-4 interleukin 6 Homo sapiens 181-185 31476115-7 2019 Our results show that APZ and the known DHCR7 inhibitor, AY9944, increase 7-DHC levels in airway epithelial cells and potentiate O3-induced IL-6 and IL-8 expression and cytokine release. trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride 57-63 interleukin 6 Homo sapiens 140-144 31132733-5 2019 In addition, L-fucose can inhibit macrophage M1 polarization, inactivate the NLRP3 inflammasome and reduce the release of TNFalpha, IL1beta, IL6 pro-inflammatory cytokines. Fucose 13-21 interleukin 6 Homo sapiens 141-144 17761160-3 2007 FK506 and cyclosporine A, calcineurin inhibitors, partially inhibited UTP-induced IL-6 mRNA expression and protein production. Tacrolimus 0-5 interleukin 6 Homo sapiens 82-86 31268153-7 2019 Importantly, HCQ was determined to affect multiple pathways, including "negative regulation of endothelial cell proliferation", "blood vessel remodeling", "cell surface receptor signaling pathways" and "notch receptor processing" associated with "signal transduction", "cancers" and "immune system", through regulating C-X-C motif chemokine ligand 8, TNF, IL6, intercellular adhesion molecule 1 and FOS genes. Hydroxychloroquine 13-16 interleukin 6 Homo sapiens 356-359 31517562-7 2019 Fluticasone propionate (FP) and dexamethasone (DEX) suppressed IL-6 and IL-8 production in BEAS-2B cells, but clarithromycin (CAM) failed to do so. Fluticasone 0-22 interleukin 6 Homo sapiens 63-67 17761160-4 2007 In addition, combined application of FK506 and PD98059 synergistically inhibited the UTP-induced IL-6 production. Tacrolimus 37-42 interleukin 6 Homo sapiens 97-101 31517562-7 2019 Fluticasone propionate (FP) and dexamethasone (DEX) suppressed IL-6 and IL-8 production in BEAS-2B cells, but clarithromycin (CAM) failed to do so. Fluticasone 24-26 interleukin 6 Homo sapiens 63-67 17581928-7 2007 On the other hand, IL-6 increased the level of 5-(and-6)-chloromethyl-2",7"-dichlorodihydrofluorescein diacetate-sensitive cellular reactive oxygen species (ROS), and IL-6-induced increases in alpha-MG uptake and the protein expression level of SGLTs were blocked by ascorbic acid or taurine (antioxidants). Ascorbic Acid 267-280 interleukin 6 Homo sapiens 19-23 18246796-4 2007 The siRNAs were transfected into MG-63 cells and HSF cells via oligofectamine. oligofectamine 63-77 interleukin 6 Homo sapiens 49-52 31383729-0 2019 Delta9-Tetrahydrocannabinol Suppresses Monocyte-Mediated Astrocyte Production of Monocyte Chemoattractant Protein 1 and Interleukin-6 in a Toll-Like Receptor 7-Stimulated Human Coculture. Dronabinol 0-27 interleukin 6 Homo sapiens 120-133 31383729-8 2019 THC treatment of the TLR7-stimulated coculture suppressed monocyte secretion of IL-1beta, resulting in decreased astrocyte production of MCP-1 and IL-6. Dronabinol 0-3 interleukin 6 Homo sapiens 147-151 31162611-5 2019 Regardless of intestinal inflammation, supplementation with SB at 300 mg/kg significantly decreased the levels of D (-)-lactate (P < 0.05), interleukin-6, and interleukin-1beta (P < 0.05) but increased the level of interleukin-10 (P < 0.05). Butyric Acid 60-62 interleukin 6 Homo sapiens 143-156 31108325-19 2019 A comparison of patients who did or did not tolerate EEN revealed significant differences in the plasma levels of Ach, TNF-alpha, IL6 and CCK (p < .05). estradiol enanthate 53-56 interleukin 6 Homo sapiens 130-133 31418397-7 2019 Thirteen cytokines were measured by CBA assay, besides IL-6 level was confirmed to be higher in iMCD group than that in healthy controls (P<0.01), IL-12-p70 and IL-33 levels were also higher in iMCD group than those in control group (P<0.05), no significant difference of the rest cytokines was found between iMCD and the control group. imcd 96-100 interleukin 6 Homo sapiens 55-59 17667496-10 2007 Elevated plasma levels of IL-6, IL-8, complement C3a, and IL-1ra as well as expression of CD11b, L- and P-selectin, and platelet-leukocyte aggregates were significantly attenuated by systemic lidocaine. Lidocaine 192-201 interleukin 6 Homo sapiens 26-30 31085401-4 2019 A thio-terminated aptamer specific for interleukin-6 was immobilized on the surface of the modified electrode via the formation of gold-sulfur bonds. Sulfur 136-142 interleukin 6 Homo sapiens 39-52 31287013-8 2019 RESULTS: Flubendazole blocked the IL6-induced nuclear translocation of STAT3, which led to inhibition of the transcription of STAT3 target genes, such as MCL1, VEGF and BIRC5. flubendazole 9-21 interleukin 6 Homo sapiens 34-37 31299628-6 2019 Under optimized conditions, the assay works in the 1 pg/mL to 1 mug/mL IL-6 concentration range, and the detection limit is as low as 1 pg/mL in PBS, 5 pg/mL in unprocessed whole blood. Lead 145-148 interleukin 6 Homo sapiens 71-75 30861304-5 2019 Pre-treatment with the ROS inhibitors N-acetyl cysteine (NAC) and diphenyleneiodonium (DPI) partially attenuated CXCL8 and IL-6 responses to 200 microg/mL, but not to 100 microg/mL Si50. diphenyleneiodonium 66-85 interleukin 6 Homo sapiens 123-127 30861304-5 2019 Pre-treatment with the ROS inhibitors N-acetyl cysteine (NAC) and diphenyleneiodonium (DPI) partially attenuated CXCL8 and IL-6 responses to 200 microg/mL, but not to 100 microg/mL Si50. diphenyleneiodonium 87-90 interleukin 6 Homo sapiens 123-127 31497826-5 2019 In vitro, UA inhibited the interleukin-1 beta (IL-1beta) induced over-production of nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in a concentration-dependent manner in human OA chondrocytes. 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one 10-12 interleukin 6 Homo sapiens 238-251 31497826-5 2019 In vitro, UA inhibited the interleukin-1 beta (IL-1beta) induced over-production of nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in a concentration-dependent manner in human OA chondrocytes. 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one 10-12 interleukin 6 Homo sapiens 253-257 17635746-9 2007 A statistically significant negative correlation between TNF-alpha and eicosapentaenoic acid (EPA) (r = -0.497; P < 0.05) and IL-6 and EPA (r = -468; P = 0.03) was found in HD patients before supplementation. Eicosapentaenoic Acid 138-141 interleukin 6 Homo sapiens 129-133 30325468-8 2019 Feeding PA supplemented diets downregulated the expression of CD40LG (P < 0.001), IFNG, and IL6 (P < 0.05). Protactinium 8-10 interleukin 6 Homo sapiens 92-95 30608861-9 2019 Targeting STAT3 activity using the small-molecule inhibitor STA-21 attenuated IL-6 production, reduced p21 levels, decreased senescence-associated beta-galactosidase accumulation, and restored normal mitochondrial function. STA-21 60-66 interleukin 6 Homo sapiens 78-82 31060888-0 2019 In vitro inhibitory effects of cirsiliol on IL-6-induced STAT3 activation through anti-inflammatory activity. cirsiliol 31-40 interleukin 6 Homo sapiens 44-48 17466485-0 2007 Simvastatin and fluvastatin reduce interleukin-6 and interleukin-8 lipopolysaccharide (LPS) stimulated production by isolated human monocytes from chronic kidney disease patients. Simvastatin 0-11 interleukin 6 Homo sapiens 35-48 31060888-2 2019 Here, we investigated the signaling pathway involved in the anti-inflammatory effects of cirsiliol on IL-6-induced activity. cirsiliol 89-98 interleukin 6 Homo sapiens 102-106 17466485-2 2007 AIM: To evaluate the in vitro effect of simvastatin (S) or fluvastatin (F) on the lipopolysaccharide (LPS) stimulated secretion of IL-6 and IL-8 from monocytes of chronic kidney disease patients (CKD) in K-DOQI stages 3-5. Simvastatin 40-51 interleukin 6 Homo sapiens 131-135 31060888-4 2019 At the molecular level, cirsiliol suppressed the expression of IL-6-induced inflammatory marker genes such as CRP, IL-1beta, ICAM-1 and SOCS3, IL-6-induced activation of Jak2, gp130, STAT3 and ERK and nuclear translocation of STAT3, as measured by PCR, immunofluorescence staining and western blot analysis. cirsiliol 24-33 interleukin 6 Homo sapiens 63-67 31152816-2 2019 In this study, we found that expression of miR-143 is decreased, whereas that of Interleukin 6 (IL-6) is increased in blood samples of Cr(VI)-exposing workers compared with corresponding unexposed workers. Chromium 135-137 interleukin 6 Homo sapiens 81-94 31152816-2 2019 In this study, we found that expression of miR-143 is decreased, whereas that of Interleukin 6 (IL-6) is increased in blood samples of Cr(VI)-exposing workers compared with corresponding unexposed workers. Chromium 135-137 interleukin 6 Homo sapiens 96-100 17888208-2 2007 In this study we evaluate whether simvastatin could influence the production of pro-inflammatory cytokines (interleukin (IL)-6 and IL-8) and nitric oxide (NO) by activated human chondrocytes. Simvastatin 34-45 interleukin 6 Homo sapiens 108-126 31152816-3 2019 In addition, IL-6 was increased in human bronchial epithelial cells (BEAS-Cr) exposed to Cr(VI) compared with unexposed BEAS-2B cells. Chromium 74-76 interleukin 6 Homo sapiens 13-17 31152816-7 2019 These outcomes support the hypothesis that the miR-143/IL-6/HIF-1alpha pathway functions to regulate Cr(VI)-induced carcinogenesis. Chromium 101-103 interleukin 6 Homo sapiens 55-59 31060888-4 2019 At the molecular level, cirsiliol suppressed the expression of IL-6-induced inflammatory marker genes such as CRP, IL-1beta, ICAM-1 and SOCS3, IL-6-induced activation of Jak2, gp130, STAT3 and ERK and nuclear translocation of STAT3, as measured by PCR, immunofluorescence staining and western blot analysis. cirsiliol 24-33 interleukin 6 Homo sapiens 143-147 31060888-6 2019 These results indicate that cirsiliol attenuates IL-6-induced cellular signaling by regulating Jak2 phosphorylation. cirsiliol 28-37 interleukin 6 Homo sapiens 49-53 31060888-7 2019 Therefore, cirsiliol could be a therapeutic agent for IL-6-related inflammatory diseases. cirsiliol 11-20 interleukin 6 Homo sapiens 54-58 17888208-5 2007 RESULTS: Simvastatin demonstrated significant dose-dependent inhibition of IL-6 and IL-8 production of isolated chondrocytes and cartilage explants up to 99% for IL-6 and up to 88% for IL-8 (p < 0.01). Simvastatin 9-20 interleukin 6 Homo sapiens 75-79 31282647-9 2019 Systemic administration of a nonopioid, blood-brain barrier permeable TLR4 antagonist (+)-naloxone inhibited METH-induced activation of microglia and IL-6 mRNA overexpression in VTA. Naloxone 86-98 interleukin 6 Homo sapiens 150-154 17888208-5 2007 RESULTS: Simvastatin demonstrated significant dose-dependent inhibition of IL-6 and IL-8 production of isolated chondrocytes and cartilage explants up to 99% for IL-6 and up to 88% for IL-8 (p < 0.01). Simvastatin 9-20 interleukin 6 Homo sapiens 162-166 17502394-6 2007 In contrast, vaccination with JBCG resulted in significantly greater expression of cytokines characteristic of a proinflammatory immune response (IL-1alpha, IL-1beta, IL-6, and IL-24) in PBMC activated with CFP compared to PBMC from children vaccinated with BBCG or DBCG. jbcg 30-34 interleukin 6 Homo sapiens 167-171 31598337-0 2019 Anticancer Activity of Tubulosine through Suppression of Interleukin-6-Induced Janus Kinase 2/Signal Transducer and Activation of Transcription 3 Signaling. tubulosine 23-33 interleukin 6 Homo sapiens 57-70 31004887-11 2019 After multiple adjustment, elevated ET-1 and IL-6 were significantly correlated with increased gestational BP, and respectively mediated 1.24%-25.06% and 7.01%-10.69% of the increased BP due to PM2.5 and Pb constituent exposure. Lead 204-206 interleukin 6 Homo sapiens 45-49 31091864-3 2019 Among the prepared thienopyrimidine derivatives, 6Aa, 6Ab, 6Ba and 6Bc significantly suppressed the phosphorylation of STAT3 and ERK1/2 stimulated by IL-6 in Hep3B cells. thienopyrimidine 19-35 interleukin 6 Homo sapiens 150-154 31598337-6 2019 Results: Tubulosine exhibited anticancer activity in IL-6-stimulated human breast cancer cells. tubulosine 9-19 interleukin 6 Homo sapiens 53-57 31598337-8 2019 Additionally, tubulosine suppressed IL-6-induced Janus kinase 2 (JAK2)/STAT3 signaling, resulting in decreased viability and induction of apoptotic cell death in breast cancer cells. tubulosine 14-24 interleukin 6 Homo sapiens 36-40 31598337-9 2019 Interestingly, inhibition of IL-6-induced JAK2/STAT3 signaling by tubulosine was associated with the blocking of IL-6 receptor (IL-6R) and glycoprotein 130 (gp130) binding. tubulosine 66-76 interleukin 6 Homo sapiens 29-33 31598337-10 2019 Conclusion: Tubulosine exhibits anticancer activity through functional inhibition of IL-6-induced JAK2/STAT3 signaling by targeting IL-6Ralpha/gp130 binding in breast cancer cells. tubulosine 12-22 interleukin 6 Homo sapiens 85-89 31236002-10 2019 The Th17 cell percentages, Th17/Treg cell ratios, IL-17, IL-23, and IL-6 levels of the EEN group were lower than those of the DEN group on the 7th day after admission (P < 0.05). estradiol enanthate 87-90 interleukin 6 Homo sapiens 68-72 17449045-3 2007 Binding of IL-6 in the presence of ammonium sulfate (AS) was tested using low- and high-substituted phenyl-sepharose. phenyl-sepharose 100-116 interleukin 6 Homo sapiens 11-15 17449045-6 2007 These results demonstrate that arginine weakens hydrophobic interactions between IL-6 and the phenyl-sepharose. phenyl-sepharose 94-110 interleukin 6 Homo sapiens 81-85 16781858-5 2007 Both EPA and DHA reduced TNF-alpha, IL-1beta and IL-6 mRNA expression. Eicosapentaenoic Acid 5-8 interleukin 6 Homo sapiens 49-53 30758914-11 2019 Also, ALA treatment abrogated increases in the interleukin-6 and -8 levels induced by UPM in nasal fibroblasts. Thioctic Acid 6-9 interleukin 6 Homo sapiens 47-67 31453296-6 2019 In T1D patients, we show that secretion of cytokines IL-1beta, TNFalpha, IL-6 and IFNalpha after microbial DNA stimulation is promoted by potassium efflux and is not dependent on P2X7 receptor signaling. Potassium 138-147 interleukin 6 Homo sapiens 73-77 16781858-7 2007 Furthermore, a low dose (25 microM) of DHA had a greater inhibitory effect than that of EPA on macrophage IL-1beta (P<.01 and P<.04, respectively) and IL-6 (P<.003 and P<.003, respectively) production following 0.01 and 0.1 microg/ml LPS stimulation. Eicosapentaenoic Acid 88-91 interleukin 6 Homo sapiens 157-161 17094021-5 2007 DA-9601 dose-dependently decreased the gene expression and production of TNF-alpha, IL-1beta, and IL-6 on phorbol 12-myristate 13-acetate (PMA)- and calcium ionophore A23187-stimulated HMC-1 cells. Calcimycin 167-173 interleukin 6 Homo sapiens 98-102 31004593-6 2019 Furthermore, knockdown of lnc-p21 mitigated MPP+-induced oxidative stress and neuroinflammation, as evidenced by the decrease in ROS generation, increase in SOD activity and decline in TNF-alpha, IL-1beta and IL-6 levels. mangion-purified polysaccharide (Candida albicans) 44-48 interleukin 6 Homo sapiens 209-213 31245005-10 2019 Conversely, women with high palmitoleic, oleic, and linolenic acid levels had reduced odds (>=2-fold, p<0.01 to p<0.001) for having higher IL-8, IL-6 or tumor necrosis factor-alpha levels. oleic 34-39 interleukin 6 Homo sapiens 145-149 17335379-1 2007 BACKGROUND: In previous work, the cyclooxygenase-2 inhibitor NS-398 inhibited interleukin (IL)-1beta-stimulated prostaglandin E(2) (PGE(2)) production almost completely while partially inhibiting IL-6 production in aggressive periodontitis (AgP) human gingival fibroblasts. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 61-67 interleukin 6 Homo sapiens 196-200 31245005-10 2019 Conversely, women with high palmitoleic, oleic, and linolenic acid levels had reduced odds (>=2-fold, p<0.01 to p<0.001) for having higher IL-8, IL-6 or tumor necrosis factor-alpha levels. alpha-Linolenic Acid 52-66 interleukin 6 Homo sapiens 145-149 30615197-4 2019 Here we show that three novel small molecule IL-6 inhibitors, madindoline-5 (MDL-5), MDL-16 and MDL-101, significantly suppress IL-17 production in myelin-specific CD4 T cells in a dose-dependent manner in vitro. madindoline A 62-73 interleukin 6 Homo sapiens 45-49 31186039-11 2019 Notably, our studies revealed the mechanism that Ilamycin C can induce Bax/Bcl-2-related caspase-dependent apoptosis and inhibit migration and invasion through MMP2/MMP9/vimentin/fascin in TNBC by suppressing IL-6-induced STAT3 phosphorylation. ilamycin c 49-59 interleukin 6 Homo sapiens 209-213 16946718-4 2007 The P2 antagonists, suramin-, reactive blue 2-, and periodate-oxidized ATP, inhibited ATP-induced IL-6 release, whereas pyridoxal-phosphate-6-azophenyl-2",4"-disulfonic acid, adenosine 3"-phosphate 5"-phosphate, 1-[N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, and pertussis toxin did not. Suramin 20-27 interleukin 6 Homo sapiens 98-102 31186039-12 2019 CONCLUSIONS: This study provides the first evidence that Ilamycin C has significant implications for the potential as a novel IL-6/STAT3 inhibitor for TNBC treatment in the future. ilamycin c 57-67 interleukin 6 Homo sapiens 126-130 17068203-5 2007 In addition, the in vivo effects of cocaine (40 mg) versus placebo on monocyte expression of TNF-alpha and IL-6 were profiled over 48 h. Cocaine-dependent volunteers showed a decrease in the capacity of monocytes to express TNF-alpha and IL-6 compared with control subjects. Cocaine 137-144 interleukin 6 Homo sapiens 107-111 31138166-9 2019 Importantly, activation of alpha7nAChR with its agonist PNU-282987 inhibited NF-kappaB, decreased TNF-alpha, IL-1beta, and IL-6 release, and increased IL-10 release in monocytes from the PE women (all p < 0.01). PNU-282987 56-66 interleukin 6 Homo sapiens 123-127 30362520-8 2019 Soluble factors derived from cyclooxygenase-2 and IL-6 pathways were involved in H8-EA.hy926 interaction under the LPA effect. lysophosphatidic acid 115-118 interleukin 6 Homo sapiens 50-54 30362520-9 2019 Moreover, LPA increased the levels of IL-6 mRNA by cyclooxygenase-2 pathway in H8 cells. lysophosphatidic acid 10-13 interleukin 6 Homo sapiens 38-42 17068203-5 2007 In addition, the in vivo effects of cocaine (40 mg) versus placebo on monocyte expression of TNF-alpha and IL-6 were profiled over 48 h. Cocaine-dependent volunteers showed a decrease in the capacity of monocytes to express TNF-alpha and IL-6 compared with control subjects. Cocaine 137-144 interleukin 6 Homo sapiens 238-242 17113069-4 2007 Scopoletin significantly and dose-dependently inhibits the way in which phorbol 12-myristate 13-acetate (PMA) plus A23187 induces the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 (P<0.05). Calcimycin 115-121 interleukin 6 Homo sapiens 214-232 31010006-4 2019 Our present findings confirm that vincristine stimulates the secretion of tumor growth factors class beta and interleukin-6 from cancer-associated fibroblasts as a result of paracrine stimulation by cancer cells. Vincristine 34-45 interleukin 6 Homo sapiens 110-123 31091693-5 2019 In PA model rodents, aldosterone decreased insulin-secretion and the islet/pancreas area ratio and eplerenone added on aldosterone (E+A) restored those with induction of IL-6 in alpha-cells. Eplerenone 99-109 interleukin 6 Homo sapiens 170-174 17668557-7 2007 RESULTS: In human adipocytes, PIs and NRTIs (except amprenavir, atazanavir and abacavir) reduced lipid content, adiponectin and leptin release and increased in parallel ROS production and monocyte chemoattractant protein (MCP)-1 and interleukin (IL)-6 release. Monothiopyrophosphoric acid 30-33 interleukin 6 Homo sapiens 233-251 31934009-5 2019 Pearson correlation analysis showed that the serum 25(OH)D level in patients with T2DM had a negative correlation with HOMA-IR (r=-0.750, P<0.001), TNF-alpha (r=-0.705, P<0.001), IL-1beta (r=-0.661, P<0.001), IL-8 (r=-0.645, P<0.001), and IL-6 (r=-0.609, P<0.001). 25-hydroxyvitamin D3-bromoacetate 51-58 interleukin 6 Homo sapiens 251-255 30300034-11 2019 In addition, a positive association between IL-6 rs1800796 and the risk of chronic periodontitis was detected under the models of allele [G vs. C], GG vs. CC, GG vs. CC+ CG and carrier [G vs. C] (all P < 0.05, OR > 1). cysteinylglycine 170-172 interleukin 6 Homo sapiens 44-48 30465781-1 2019 Fluticasone propionate uptake in the presence of a proprietary cell-penetrating peptide (human stimulus factor, [HSF]) based on the N-terminal domain of lactoferrin was studied, alone and in combination with salmeterol, using an air interface Calu-3 epithelial model. Fluticasone 0-22 interleukin 6 Homo sapiens 113-116 30811877-3 2019 METHODS AND RESULTS: Analyses of culture supernatants from lipopolysaccharide-stimulated BV2 microglia show that urolithin A (2.5-10 microm) produced significant reduction in the production of nitrite, tumor necrosis factor (TNF)-alpha and IL-6. 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one 113-124 interleukin 6 Homo sapiens 240-244 17135765-5 2007 RESULTS: EGCG (100 microM) inhibited PMA+A23187-induced TNF-alpha, IL-6 and IL-8 expression and production. Calcimycin 41-47 interleukin 6 Homo sapiens 67-71 18260853-10 2007 At the background of therapy with simvastatin we noted significant lowering of proinflammatory cytokines (TNFalpha, IL-1beta, IL-6, IL-8) in blood serum irrespective of level of low density lipoprotein cholesterol, betterment of functional state of the left ventricle, positive clinical dynamics of CHF. Simvastatin 34-45 interleukin 6 Homo sapiens 126-130 30585337-7 2019 The serum concentration of IL-6 decreased significantly in ALA group in comparison with the placebo group, at end of the study (P = 0.049). Thioctic Acid 59-62 interleukin 6 Homo sapiens 27-31 30585337-12 2019 WHAT IS NEW AND CONCLUSION: Collectively, ALA supplementation improved serum adiponectin and IL-6 levels, without changing serum liver enzymes and liver steatosis in obese patients with NAFLD. Thioctic Acid 42-45 interleukin 6 Homo sapiens 93-97 30783936-8 2019 The changing levels of As, Zn and Se seems to affect the severity of inflammatory reactions based on IL-6, IL-10 and TNF-alpha levels (r = 0.755, r = 0.679 and r = 0.617, respectively, for all p < 0.01). Selenium 34-36 interleukin 6 Homo sapiens 101-105 17237271-7 2007 The interleukin 6-stimulated activation of STAT3 and Akt was inhibited not only by atiprimod but also by LY294002, a phosphoinositide-3-kinase-specific inhibitor, and by NS398, a cyclooxygenase-2-selective inhibitor. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 170-175 interleukin 6 Homo sapiens 4-17 30918241-16 2019 CONCLUSIONS Sufentanil stimulation triggers downregulation of inflammatory factors such as HIF-1alpha, TNF-alpha, IL-1ss, and IL-6, possibly through suppressing the p38/ERK/JNK/NF-kappaB-p65/COX2 pathways, and thereby reduces the damage to IR hepatic cells. Sufentanil 12-22 interleukin 6 Homo sapiens 126-130 30465781-2 2019 The HSF enhanced uptake and transport of fluticasone propionate across the epithelial barrier when alone and in presence of salmeterol. Fluticasone 41-63 interleukin 6 Homo sapiens 4-7 17344653-3 2007 Recently, it has been demonstrated that vitamin C has an inhibitory effect on the expression of pro-inflammatory cytokines such as interleukin (IL)-6 and tumor necrosis factor alpha (TNF-alpha) in adult whole blood cells in vitro. Ascorbic Acid 40-49 interleukin 6 Homo sapiens 131-149 30871575-11 2019 We show that miR-338-5p can bind to the interleukin 6 (IL-6) 3" untranslated region and can regulate IL-6 mRNA and protein levels in vitro. mir-338-5p 13-23 interleukin 6 Homo sapiens 40-53 30871575-11 2019 We show that miR-338-5p can bind to the interleukin 6 (IL-6) 3" untranslated region and can regulate IL-6 mRNA and protein levels in vitro. mir-338-5p 13-23 interleukin 6 Homo sapiens 55-59 30871575-11 2019 We show that miR-338-5p can bind to the interleukin 6 (IL-6) 3" untranslated region and can regulate IL-6 mRNA and protein levels in vitro. mir-338-5p 13-23 interleukin 6 Homo sapiens 101-105 30871575-13 2019 CONCLUSIONS: We propose that lower pretreatment levels of miR-338-5p in poor responders are linked to IL-6 levels and inflammation in CRPS. mir-338-5p 58-68 interleukin 6 Homo sapiens 102-106 30690246-7 2019 The increase of IL-6 showed a statistically significant correlation with myristic acid, to a lesser extent with cis-9-eicosenoic acid and to the least extent with docosahexaenoic acid, inversely with pentadecanoic, gamma-linolenic and stearic acids. Myristic Acid 73-86 interleukin 6 Homo sapiens 16-20 30887238-1 2019 A physiologically based pharmacokinetic (PBPK) model was used to simulate the impact of elevated levels of interleukin (IL)-6 on the exposure of several orally administered cytochrome P450 (CYP) probe substrates (caffeine, S-warfarin, omeprazole, dextromethorphan, midazolam, and simvastatin). Dextromethorphan 247-263 interleukin 6 Homo sapiens 107-125 17344653-7 2007 RESULTS: In contrast to our previous observations from adult whole blood cells, 20 mM vitamin C mildly stimulated the percentage of neonatal monocytes producing IL-6 after lipopolysaccharide stimulation (e.g., 11.3% increase compared to control, p = 0.005). Ascorbic Acid 86-95 interleukin 6 Homo sapiens 161-165 31933895-9 2019 Additionally, dioscin downregulated interleukin-6 (IL-6), IL-1beta and tumor necrosis factor alpha (TNF-alpha). dioscin 14-21 interleukin 6 Homo sapiens 36-49 31933895-9 2019 Additionally, dioscin downregulated interleukin-6 (IL-6), IL-1beta and tumor necrosis factor alpha (TNF-alpha). dioscin 14-21 interleukin 6 Homo sapiens 51-55 30866863-12 2019 Furthermore, the inhibitory effects of BrMC and chrysin on stemness of SMMC-7721 cells and activation of LX-2 cells were attenuated by addition of IL-6 or HGF, and enhanced by deletion of IL-6 or HGF. brmc 39-43 interleukin 6 Homo sapiens 147-151 17079162-4 2007 Fisetin decreased phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated gene expression and production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-4, IL-6, and IL-8 in HMC-1 cells. Calcimycin 73-79 interleukin 6 Homo sapiens 204-208 30866863-12 2019 Furthermore, the inhibitory effects of BrMC and chrysin on stemness of SMMC-7721 cells and activation of LX-2 cells were attenuated by addition of IL-6 or HGF, and enhanced by deletion of IL-6 or HGF. brmc 39-43 interleukin 6 Homo sapiens 188-192 32255011-0 2019 Bead-type polystyrene/nano-CaCO3 (PS/nCaCO3) composite: a high-performance adsorbent for the removal of interleukin-6. Polystyrenes 34-36 interleukin 6 Homo sapiens 104-117 32255011-3 2019 It was revealed that the incorporation of nCaCO3 into the PS matrix enhanced both the mechanical strength which can prevent the fragmentation and its adsorption capacity for interleukin-6 (IL-6, MW = 24.0 kDa) from human plasma. Polystyrenes 58-60 interleukin 6 Homo sapiens 174-187 32255011-3 2019 It was revealed that the incorporation of nCaCO3 into the PS matrix enhanced both the mechanical strength which can prevent the fragmentation and its adsorption capacity for interleukin-6 (IL-6, MW = 24.0 kDa) from human plasma. Polystyrenes 58-60 interleukin 6 Homo sapiens 189-193 30227141-6 2019 QC was more effective than HCQ at inhibiting the toll receptor-mediated production of TNF-alpha and IL-6 in the peripheral blood mononuclear cells isolated from cutaneous lupus erythematosus patients, whereas QC and HCQ inhibited IFN-alpha equally. Hydroxychloroquine 27-30 interleukin 6 Homo sapiens 100-104 17075836-8 2006 SMV prevented the increase in NF-kappaB activation and rise in IL-1beta and IL-6 levels induced by TNFalpha, whereas mevalonate and geranylgeranyl pyrophosphate reversed the inhibitory effects of SMV on activation of NF-kappaB and RhoA. Simvastatin 0-3 interleukin 6 Homo sapiens 76-80 30597391-8 2019 Elevated blood Pb, urinary 2-hydroxynaphthalene (2-OHNap) and SigmaOHFlu levels were associated with higher levels of IL-6, IL-12p70, IP-10, CD4+ T cell percentages, neutrophil and monocyte counts. Lead 15-17 interleukin 6 Homo sapiens 118-122 30597391-10 2019 IL-6 exerts a significant mediation effect on the relationship between blood Pb levels and IP-10, as well as the relationship between urinary SigmaOHFlu levels and IP-10. Lead 77-79 interleukin 6 Homo sapiens 0-4 30503994-12 2019 The mRNA levels of TNF-alpha, IL-6 and GFAP were significantly downregulated in animals treated by arbutin. Arbutin 99-106 interleukin 6 Homo sapiens 30-34 30745853-6 2019 Moreover, RA exposure resulted in the inhibition of interleukin-6 (IL-6)-induced JAK2/STAT3 signaling pathway activation and target gene expression in both drug-sensitive and drug-resistant cells. raddeanin A 10-12 interleukin 6 Homo sapiens 52-65 30745853-6 2019 Moreover, RA exposure resulted in the inhibition of interleukin-6 (IL-6)-induced JAK2/STAT3 signaling pathway activation and target gene expression in both drug-sensitive and drug-resistant cells. raddeanin A 10-12 interleukin 6 Homo sapiens 67-71 16968805-10 2006 Simvastatin therapy significantly decreased hsCRP levels in MS subjects compared with placebo (P < 0.0005) and resulted in a significant reduction in plasma and lipopolysaccharide-activated monocytic release of IL-6 and TNF (P < 0.025). Simvastatin 0-11 interleukin 6 Homo sapiens 214-226 30719005-5 2018 Oleic acid alone had opposite effects due to its different capacity of controlling these metabolic pathways, in particular by reduction of the ROS levels and MMP-2 activity, down-regulation of BiP, eIF2alpha, ATF6, XBP1u, CHOP, IL6, IL8 and by SOD2 and PTP-1B overexpression. Oleic Acid 0-10 interleukin 6 Homo sapiens 228-231 30569138-7 2019 Treatment of HepG2 cells for 5 h with the BA-loaded liposomes coated with chitosan at 5 mM lowered the extent of the increase in IL-8, IL-6, TNF-alpha and TGF-beta expression of approximately 64, 58, 85 and 73.8%, respectively, when compared to the untreated cells. Butyric Acid 42-44 interleukin 6 Homo sapiens 135-139 29305686-8 2019 The results indicate that the use of Bokashi as feed additives resulted in increased concentrations of pro-inflammatory cytokines TNF-alpha and IL-6, which increase the protective capacity of the colostrum by stimulating cellular immune mechanisms protecting the sow and neonates against infection. bokashi 37-44 interleukin 6 Homo sapiens 144-148 30052808-2 2019 The binary IL6:sIL6R complex is inactivated by sgp130 through the formation of the ternary IL6:sIL6R:sgp130 complex. sil6r 15-20 interleukin 6 Homo sapiens 11-14 16890260-8 2006 Furthermore, AEMD attenuated the phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-alpha, IL-8 and IL-6 secretion in human mast cells. Calcimycin 93-99 interleukin 6 Homo sapiens 131-135 30052808-2 2019 The binary IL6:sIL6R complex is inactivated by sgp130 through the formation of the ternary IL6:sIL6R:sgp130 complex. sil6r 95-100 interleukin 6 Homo sapiens 11-14 30052808-2 2019 The binary IL6:sIL6R complex is inactivated by sgp130 through the formation of the ternary IL6:sIL6R:sgp130 complex. sil6r 95-100 interleukin 6 Homo sapiens 16-19 30001171-9 2019 Serum concentrations of both IL 1-beta (R value: -0.624; P < 0.001) and IL-6 (R value: -0.642; P < 0.001) were inversely correlated to the serum concentrations of selenium. Selenium 169-177 interleukin 6 Homo sapiens 75-79 17144091-12 2006 RESULTS: Significant correlations between AoPWV and serum IL-6 were shown, whereas association with CRP was close to statistical significance (p= 0,053). aopwv 42-47 interleukin 6 Homo sapiens 58-62 30465054-3 2019 We have recently synthesized and tested the biological activity of a novel series of 4-amino-2-aryl-6,9-dichlorobenzo[g]pteridines, finding that they present anti-inflammatory properties, as they were able to inhibit in vitro the production of pro-inflammatory cytokines TNF-alpha and IL-6. 4-amino-2-aryl-6,9-dichlorobenzo[g]pteridines 85-130 interleukin 6 Homo sapiens 285-289 30273821-8 2019 The longitudinal analysis indicated that there was an effect of time, but not of treatment, on IL-6 levels, with decreasing values in both the CR and AL groups. Aluminum 150-152 interleukin 6 Homo sapiens 95-99 29714141-10 2019 We also showed that a repurposing FDA-approved drug bazedoxifene could inhibit the IL-6/IL-6R/GP130 complexes. bazedoxifene 52-64 interleukin 6 Homo sapiens 83-87 29714141-11 2019 Bazedoxifene also inhibited JAK1 binding to IL-6/IL-6R/GP130 complexes and STAT3 phosphorylation. bazedoxifene 0-12 interleukin 6 Homo sapiens 44-48 29714141-12 2019 In addition, bazedoxifene impeded IL-6 mediated cell viability/ proliferation and glycolysis in pancreatic cancer cells. bazedoxifene 13-25 interleukin 6 Homo sapiens 34-38 29714141-13 2019 Consistently, other IL-6/GP130 inhibitors SC144 and evista showed similar inhibition of IL-6 stimulated cell viability, cell proliferation and glycolysis. Raloxifene Hydrochloride 52-58 interleukin 6 Homo sapiens 20-24 29714141-13 2019 Consistently, other IL-6/GP130 inhibitors SC144 and evista showed similar inhibition of IL-6 stimulated cell viability, cell proliferation and glycolysis. Raloxifene Hydrochloride 52-58 interleukin 6 Homo sapiens 88-92 16716291-6 2006 UTP increased IL-6 mRNA and protein levels, and the increases were inhibited by a P2 purinergic receptor antagonist (suramin, 300 microM). Suramin 117-124 interleukin 6 Homo sapiens 14-18 30844798-11 2019 CDCA-induced IL-6 and IL-8 mRNA levels were blocked by guggulsterone. pregna-4,17-diene-3,16-dione 55-68 interleukin 6 Homo sapiens 13-17 30844798-12 2019 CDCA increased IL-6, tumor necrosis factor-alpha (TNF-alpha), and vascular endothelial growth factor release, whereas guggulsterone significantly blocked IL-6 and TNF-alpha release. pregna-4,17-diene-3,16-dione 118-131 interleukin 6 Homo sapiens 154-158 31113580-7 2019 Following oleic acid (OA) treatment of HepG2 cells, TLR4, TNFa, and IL-6 levels were significantly decreased in the miR-182-5p group as compared with levels observed in controls. Oleic Acid 10-20 interleukin 6 Homo sapiens 68-72 16716291-7 2006 While a protein kinase C inhibitor (GF109203X, 10 microM) was without effect, an intracellular free Ca2+ chelator (BAPTA-AM, 50 microM) suppressed UTP-mediated IL-6 induction. 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 115-123 interleukin 6 Homo sapiens 160-164 30472018-8 2019 The catabolic factor IL-6 also had a significant decline from baseline (77% decrease in median, P < .05) after 1 week of naproxen use. Naproxen 124-132 interleukin 6 Homo sapiens 21-25 30622945-10 2018 Moreover, PL induced an early and transient increase of the pro-inflammatory response triggered by IL-1alpha, by inducing COX-2 expression and secretion of a large amount of PGE2, IL-6, and IL-8. pl 10-12 interleukin 6 Homo sapiens 180-184 16682487-5 2006 IL-6 protein concentration in the medium was measured after TSH stimulation. Thyrotropin 60-63 interleukin 6 Homo sapiens 0-4 30574167-10 2018 At 1:102 dilution, IL-6 secretion was significantly lower with MP-AzeFlu (38.3 +- 4.2%, compared with FBS = 100%) than with AZE (76.1 +- 4.9%) or FP (53.0 +- 4.9%). mp-azeflu 63-72 interleukin 6 Homo sapiens 19-23 30472018-10 2019 CONCLUSIONS: Naproxen use diminished several biological factors in LR-PRP; however, a 1-week washout period was sufficient for the recovery of PDGF-AA, PDGF-AB, and IL-6 to return to baseline levels. Naproxen 13-21 interleukin 6 Homo sapiens 165-169 30416166-6 2019 The LTCC antagonist nicardipine inhibited lipopolysaccharide (LPS)- and interleukin-33 (IL-33)-mediated Zinc wave and the induction of cytokine genes such as IL-6. Nicardipine 20-31 interleukin 6 Homo sapiens 158-162 30360768-3 2019 PE from EVOO treatment inhibited IL-1beta-induced matrix metalloproteases (P&lt;0 001), TNF-alpha and IL-6 production (P&lt;0 001). evoo 8-12 interleukin 6 Homo sapiens 106-110 16682487-8 2006 IL-6 responsiveness to TSH was observed upon differentiation, but only for subcutaneous adipocytes (1.9-fold over basal, P < 0.001). Thyrotropin 23-26 interleukin 6 Homo sapiens 0-4 30504327-7 2018 In 2014, the anti-IL-6 therapy siltuximab became the first iMCD treatment approved by the US Food and Drug Administration, on the basis of a 34% durable response rate; consensus guidelines recommend it as front-line therapy. imcd 59-63 interleukin 6 Homo sapiens 18-22 30502651-3 2019 In vitro, DV281 potently induced Interferon (IFN)-alpha from monkey and human peripheral blood mononuclear cells (PBMCs), stimulated interleukin-6 production and proliferation in human B cells, and induced TLR9-dependent cytokine responses from mouse splenocytes. dv281 10-15 interleukin 6 Homo sapiens 133-146 30409167-9 2018 Proliferation and migration of human dermal fibroblasts and in vivo wound healing were improved in the CMs derived from AF-MSCs exposed to selenium and bFGF, which was caused by the Smad2, AKT-MEK1/2-ERK, and NFkappaB signaling triggered by the paracrine factors of AF-MSCs, such as TGF-beta, VEGF, and IL-6. Selenium 139-147 interleukin 6 Homo sapiens 303-307 16682487-9 2006 To determine if TSH could stimulate IL-6 release from extrathyroidal tissues in vivo, we measured serum IL-6 levels from five thyroidectomized patients who received recombinant human (rh) TSH and found that levels increased by threefold on days 3 and 4 (P < 0.05) after its administration. Thyrotropin 16-19 interleukin 6 Homo sapiens 36-40 30051214-9 2018 The serum IL-6 and CRP levels were inversely correlated with the plasma concentration ratios of N-desmethyltramadol to tramadol and of N,O-didesmethyltramadol to O-desmethyltramadol. O-demethyltramadol 162-181 interleukin 6 Homo sapiens 10-14 30662368-8 2018 Significant changes were observed in fluoxetine treatment compared to baseline: proinflammatory cytokines IFN-gamma, IL-1beta, TNF-alpha, IL-6, IL-12, and IL-15 were decreased only at week 4 whereas IL-2 was increased only at week 8; anti-inflammatory cytokines IL-4 and IL-5 were increased at week 8 while IL-1Ra was reduced only at week 4. Fluoxetine 37-47 interleukin 6 Homo sapiens 138-142 16682487-10 2006 Our data demonstrate that stage of differentiation and fat depot origin affect basal and TSH-stimulated IL-6 release from adipose cells in culture. Thyrotropin 89-92 interleukin 6 Homo sapiens 104-108 16682487-11 2006 Furthermore, rhTSH elevates serum IL-6 response in thyroidectomized patients, indicating an extrathyroidal site of TSH action. Thyrotropin 15-18 interleukin 6 Homo sapiens 34-38 16381797-5 2006 Inhibitors of IP(3)-dependent Ca(2+) signals, like 2-aminoethoxydiphenyl borate (2-APB) and U-73122, decreased activation of IL-6 gene expression as did Ca(2+) signals inhibitor BAPTA-AM, whereas ryanodine, a fast Ca(2+) transient inhibitor, had no effect on IL-6 induction. 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 178-186 interleukin 6 Homo sapiens 125-129 28987470-10 2018 Messenger RNA (mRNA) of the Nuclear Factor kappa beta (NF-kappaB) and its target genes InterLeukin 1 beta (IL-1beta) and IL-6 was downregulated significantly (p < 0.05) in leukocytes from DMD boys supplemented with omega-3 long chain-PUFA for 6 months, compared to the placebo group. omega-3 215-222 interleukin 6 Homo sapiens 121-125 30422744-4 2018 We found that TQ treatment resulted in a significant upregulation of phagocytic activity, respiratory burst, the production of interleukin-2 (IL-2), IL-6, and IL-17 in NecrJCL-pulsed Mphi co-culture system, and, conversely, in downregulation of the production of IL-6, IL-17, nitric oxide (NO), and arginase activity in nonpulsed TQ-treated Mphis co-culture system. thymoquinone 14-16 interleukin 6 Homo sapiens 149-153 30298070-9 2018 BLf was also more efficient than ferrous sulfate in AI treatment in HT pregnant and non-pregnant women by decreasing both serum IL-6 (from 89 +- 8 to 58 +- 6 pg/ml) and hepcidin (from 115 +- 23 to 65 +- 10 ng/ml), thus increasing hematological parameters, such as the number of red blood cells (RBCs), the concentration of hemoglobin, TSI and serum ferritin. ferrous sulfate 33-48 interleukin 6 Homo sapiens 128-132 30193323-9 2018 Treatment with idelalisib inhibited the IL-1beta-induced expression of IL-6 and IL-8. idelalisib 15-25 interleukin 6 Homo sapiens 71-75 30422744-4 2018 We found that TQ treatment resulted in a significant upregulation of phagocytic activity, respiratory burst, the production of interleukin-2 (IL-2), IL-6, and IL-17 in NecrJCL-pulsed Mphi co-culture system, and, conversely, in downregulation of the production of IL-6, IL-17, nitric oxide (NO), and arginase activity in nonpulsed TQ-treated Mphis co-culture system. thymoquinone 14-16 interleukin 6 Homo sapiens 263-267 16611671-8 2006 In subjects with UA within the normal range, UA was significantly and independently associated with neutrophils count, C-reactive protein, IL-6, IL-1ra, IL-18, and TNF-alpha, whereas non-significant trends were observed for WBC (P=0.1) and sIL-6r (P=0.2). Uric Acid 45-47 interleukin 6 Homo sapiens 139-143 30181172-7 2018 The anti-interleukin-6 monoclonal antibody siltuximab (or tocilizumab, if siltuximab is not available) with or without corticosteroids is the preferred first-line therapy for iMCD. imcd 175-179 interleukin 6 Homo sapiens 9-22 29761497-9 2018 The indomethacin significantly attenuated the increases of PGE2 , IL-6, and IL-8 expression in cells stimulated with compressive force or mechanical vibration combined with compressive force. Indomethacin 4-16 interleukin 6 Homo sapiens 66-70 29901427-8 2018 Ferulic acid significantly ameliorated HUVEC radiation injury, as evidenced by increases in cell viability and angiogenesis and decreases in G2/M cell cycle arrest and levels of high mobility group box 1 protein (HMGB1), interleukin (IL)-6 and IL-8. ferulic acid 0-12 interleukin 6 Homo sapiens 221-239 16518530-6 2006 Simvastatin exhibited a faster statistically significant decrease over time in IL-6 and sICAM 1 levels (at 7 days, p = 0.014 and p = 0.001, respectively). Simvastatin 0-11 interleukin 6 Homo sapiens 79-83 30081854-12 2018 However, IL-6 levels were significantly attenuated over the 7 day study period in the Taurolidine group compared to placebo (p = 0.04). taurolidine 86-97 interleukin 6 Homo sapiens 9-13 30081854-13 2018 In addition, IL-6 levels were significantly lower at day 7 in the Taurolidine group (p = 0.04). taurolidine 66-77 interleukin 6 Homo sapiens 13-17 30081854-17 2018 CONCLUSION: Peri-operative use of Taurolidine significantly attenuated circulating IL-6 levels in the initial 7 day post-operative period in a safe manner. taurolidine 34-45 interleukin 6 Homo sapiens 83-87 30344692-7 2018 In conclusion, based on the conventional anti-heart failure therapy, the application of milrinone can reduce the serum IL-6, TNF-alpha and Cys-C levels and improve the cardiac functions of patients effectively. Milrinone 88-97 interleukin 6 Homo sapiens 119-123 16467451-9 2006 The two coding variants, Pro32Ser (present only in black patients, 10% Ser allele) and Asp162Val (present only in white patients, 1% Val), were associated with lower levels of IL-6 and higher levels of albumin. Valine 93-96 interleukin 6 Homo sapiens 176-180 30402038-7 2018 Lonafarnib significantly suppressed LPS-, IL-1beta-, or TNF-alpha-induced IL-6, IL-8, MCP-1, and GRO-alpha expression and secretion in placental tissue. lonafarnib 0-10 interleukin 6 Homo sapiens 74-78 29902349-11 2018 Moreover, nab-PTX increased CXCL10 expression of cancer cells which blocked CAF IL-6 expression and secretion. ptx 14-17 interleukin 6 Homo sapiens 80-84 29902349-12 2018 Nab-PTX treatment could increase CXCL10 expression of cancer cells which blocks CAF cancer cell migration and invasion-promoting effect by inhibiting IL-6 expression. ptx 4-7 interleukin 6 Homo sapiens 150-154 29590534-10 2018 HIEX, but not IBU, resulted in higher levels of IL-6 (p < 0.001) and cortisol (p < 0.001) and lower active ghrelin (p < 0.001). hiex 0-4 interleukin 6 Homo sapiens 48-52 16511915-3 2006 We investigated whether simvastatin could inhibit the expression of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosis factor-alpha (TNF-alpha) in fibroblast-like synoviocytes (FLS) obtained from RA patients undergoing joint replacement therapy. Simvastatin 24-35 interleukin 6 Homo sapiens 68-81 30333271-10 2018 CONCLUSION: Alphacalcidol improves immune senescence by acting as anti-inflammatory agent through increased IL-10 and decreased IL6/IL-10 ratio and also improves cellular immunity through increased CD4/CD8 ratio and decreased CD8+ CD28- subset in elderly. alfacalcidol 12-25 interleukin 6 Homo sapiens 128-131 16511915-3 2006 We investigated whether simvastatin could inhibit the expression of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosis factor-alpha (TNF-alpha) in fibroblast-like synoviocytes (FLS) obtained from RA patients undergoing joint replacement therapy. Simvastatin 24-35 interleukin 6 Homo sapiens 83-87 29587234-9 2018 An increase in Factor 1 (+Fe, +Al, +Mn) score and a decrease in Factor 2 (-Ca, +Pb, +PAH) score were associated with increased interleukin (IL)-6 (Factor 1; p = 0.010; Factor 2; p = 0.006) and IL-8 (Factor 1; p = 0.003; Factor 2; p = 0.020) production, however, only the association with Factor 1 was evident after correcting for endotoxin and particle size. Lead 80-82 interleukin 6 Homo sapiens 127-145 29981383-5 2018 Hydroxychloroquine also inhibited CpG-induced production of interleukin-6 and tumor necrosis factor-alpha in B cell subsets. Hydroxychloroquine 0-18 interleukin 6 Homo sapiens 60-105 16511915-6 2006 RESULTS: Real-time PCR analysis revealed that the levels of IL-6 and IL-8 mRNA expressed by FLS were reduced by simvastatin in a dose-dependent manner. Simvastatin 112-123 interleukin 6 Homo sapiens 60-64 30296325-6 2018 RESULTS: The intraoperative pupil diameter was correlated with the expression of IL-6 after the femtosecond laser procedure in the FLACS indomethacin group (r = -0.53; P = .07). Indomethacin 137-149 interleukin 6 Homo sapiens 81-85 16511915-7 2006 Levels of IL-6 and IL-8 in FLS culture supernatants were decreased by simvastatin in a time-dependent and dose-dependent manner. Simvastatin 70-81 interleukin 6 Homo sapiens 10-14 30296325-9 2018 CONCLUSIONS: A smaller expression of IL-6 to the overall cytokine network value was observed in cases receiving preoperative bromfenac 0.09%, explaining improved maintenance of intraoperative mydriasis. bromfenac 125-134 interleukin 6 Homo sapiens 37-41 16511915-9 2006 These effects of simvastatin on IL-6 and IL-8 production and cell proliferation were reversed in the presence of mevalonic acid or geranylgeranyl-pyrophosphate, but not with farnesyl-pyrophosphate. Simvastatin 17-28 interleukin 6 Homo sapiens 32-36 29698923-4 2018 We find that ALA treatment leads to a reduction in lipopolysaccharide (LPS)-induced interleukin (IL)-1beta, IL-6 and tumor necrosis factor-alpha production. alpha-Linolenic Acid 13-16 interleukin 6 Homo sapiens 108-144 16511915-10 2006 CONCLUSION: Our results suggest that the beneficial effect of simvastatin in RA patients may involve inhibition of IL-6 and IL-8 production, as well as reduction of cell proliferation. Simvastatin 62-73 interleukin 6 Homo sapiens 115-119 16491457-4 2006 Coumestrol, daidzein and genistein stimulate the expression of the ERE-dependent reporter in MVLN cells and repress the activity of the IL-6 promoter in U2OS cells in a dose-dependent manner. daidzein 12-20 interleukin 6 Homo sapiens 136-140 29905044-8 2018 The results of single factor analysis showed that there were significant differences in the genotype and allele distribution of IL-6 gene promoter region-174 locus, BMD of femoral neck and lumbar vertebrae, IL-6, TRACP-5b, urine Ca, and urine Ca/Cr between the progression-free group and progression group ( P<0.05). Chromium 246-248 interleukin 6 Homo sapiens 128-132 29660509-8 2018 In particular, TA-SA-Glu exhibited a comparable anti-inflammatory efficacy to TA in terms of inhibiting the production of nitric oxide, tumor necrosis factor-alpha, and interleukin-6 in activated RAW264.7 macrophages. ta-sa-glu 15-24 interleukin 6 Homo sapiens 169-182 30294594-9 2018 Serum level of IL-10 was higher and the levels of TGF-beta, Th1 cytokines (IL-2 and IFN-gamma), and Th2 cytokines (IL-4 and IL-6) were lower in the AOS group than in the control group (P < 0.05). D-(+)-ALLOSE 148-151 interleukin 6 Homo sapiens 124-128 29804995-4 2018 The synthetic alpha(1,6)mannans exert adjuvant activities for a real vaccine antigen, tetanus toxoid (TT) in vitro, as demonstrated by the increased secretion of proinflammatory cytokines TNF-alpha and IL-6 from the treated macrophages. alpha(1,6)mannans 14-31 interleukin 6 Homo sapiens 202-206 16399222-4 2006 The JAK2 kinase inhibitor, tyrphostin AG490, suppressed the growth of MFH cells and inhibited the secretion of IL-6. Tyrphostins 27-37 interleukin 6 Homo sapiens 111-115 30072902-6 2018 The pharmacodynamic model was developed using a NLME modeling program Monolix 2016R1.The results showed that baicalein quickly suppressed release of TNF-alpha in a concentration-dependent manner, and consequently causing the diminution of IL-6 and iNOS/NO. baicalein 110-119 interleukin 6 Homo sapiens 240-244 28478304-3 2018 In turn, increased amounts of ROS/RNS and pro-inflammatory cytokines TNFalpha, IL-1beta, IL-6 led to the irreversible DNA damage, persistent DDR activation, proliferation inhibition, reduction in cell growth and immune impairment. Radon 34-37 interleukin 6 Homo sapiens 89-93 29164820-3 2018 METHODS & RESULTS: HepG2 cells treated with palmitic acid (PA;0.75 mM) showed decreased expression of various antioxidant biomarkers (SOD1, SOD2, glutathione peroxidase and catalase) and increased expression of inflammatory markers (TNFalpha, IL1beta and IL6). Protactinium 63-65 interleukin 6 Homo sapiens 259-262 16306311-6 2006 Participants with the highest serum levels of alpha-carotene, total carotenoids, and selenium were significantly less likely to be in the highest tertile of serum IL-6 at baseline (p < 0.0001). Carotenoids 68-79 interleukin 6 Homo sapiens 163-167 29477470-9 2018 In addition, JAK2/STAT3 signaling inhibitor AG490 not only produced similar inhibitory effects on EMT markers as alpha-hederin, but also synergistically enhanced alpha-hederin"s inhibitory effects on EMT markers in IL-6-treated SW620 cells. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 44-49 interleukin 6 Homo sapiens 215-219 29473951-7 2018 By contrast, low concentrations of 4-HNE, niacin and 3-OHBA down-regulated the expression of pro-inflammatory cytokines IL-6 and IL-8. 3-ohba 53-59 interleukin 6 Homo sapiens 120-124 16306311-7 2006 Those with the lowest levels of alpha- and beta-carotene, lutein/zeaxanthin, and total carotenoids were significantly more likely to have increasing IL-6 levels over a period of 2 years. Carotenoids 87-98 interleukin 6 Homo sapiens 149-153 29704670-5 2018 The results demonstrated that isorhamnetin attenuated LPS-induced release of PGE2, NO, IL-6, and IL-8 in HGFs. 3-methylquercetin 30-42 interleukin 6 Homo sapiens 87-91 16888370-10 2006 Our results additionally showed significant positive correlationsbetween baseline levels of serum IL-6 and those of iPTH, bAP and TRACP5b. benzylaminopurine 122-125 interleukin 6 Homo sapiens 98-102 30149421-8 2018 The blood lactate, serum cortisol, myoglobin, and plasma interleukin-6 concentrations were significantly higher in the DHR group than in the LR group after exercise (P < 0.05 for all variables). dhr 119-122 interleukin 6 Homo sapiens 57-70 29736207-9 2018 More importantly, systemic inhibition of IL-6/STAT3 signaling with IL-6 antibody or STAT3 inhibitor AG490 decreased the severity of pathological phenotypes of OA subchondral bone MSCs and cartilage lesions in OA. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 100-105 interleukin 6 Homo sapiens 41-45 16888370-12 2006 CONCLUSIONS: Elevated levels of serum IL-6 and bone remodeling markers, namely, bAP and TRACP5b which are common features of SHP, are effectively suppressed by calcitriol therapy. benzylaminopurine 80-83 interleukin 6 Homo sapiens 38-42 16275618-7 2005 Furthermore, GRJ decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated TNF-alpha and IL-6 secretion in human mast cells. Calcimycin 86-92 interleukin 6 Homo sapiens 118-122 29174965-5 2018 The Rv0183-specific IL-6 response was significantly higher in aTB patients (n = 128) than in those with non-TB lung disease (n = 64) and in healthy individuals (n = 327) (p < 0.0001), and not affected by latent TB infection. Terbium 63-65 interleukin 6 Homo sapiens 20-24 29174965-8 2018 CONCLUSIONS: These results clearly show that the Rv0183 antigen-specific IL-6 response has the potential to be used as an immune-diagnosis test for active TB in clinical practice. Terbium 155-157 interleukin 6 Homo sapiens 73-77 30381122-10 2018 Compared with the DMSO group, PP2Ac demethylation decreased while spindle cells, phagocytosis, and the mRNA levels of COX-2, TNF-alpha, IL-6 and CXCL10 significantly increased in the administration group with 0.5 mumol/L ABL127. Dimethyl Sulfoxide 18-22 interleukin 6 Homo sapiens 136-140 29933753-12 2018 At 72 h, CD8+ cells produced more IL-6 in severe HIE than in NAIS, but IL-6 production remained elevated in CD8 cells at 1 month in NAIS, while it decreased in HIE. nais 132-136 interleukin 6 Homo sapiens 71-75 29643949-0 2018 High Secretion of Interleukin-6 and Increased MINCLE Receptor Expression Upon Exposure to Mycobacterial Cord Factor Analog Trehalose-6, 6-Dibehenate (TDB) in Patients with Takayasu Arteritis. trehalose 6,6'-dibehenate 150-153 interleukin 6 Homo sapiens 18-31 16155293-8 2005 Collectively, these data demonstrate for the first time that trans-10, cis-12 CLA promotes NFkappaB activation and subsequent induction of IL-6, which are at least in part responsible for trans-10, cis-12 CLA-mediated suppression of peroxisome proliferator-activated receptor gamma target gene expression and insulin sensitivity in mature human adipocytes. trans-10 61-69 interleukin 6 Homo sapiens 139-143 29061481-7 2018 Furthermore, CQ pretreatment exacerbated palmitate-induced TNF-alpha and IL-6 mRNA expression in PBMCs. Chloroquine 13-15 interleukin 6 Homo sapiens 73-77 29777330-3 2018 Bazedoxifene (BZA), a third-generation selective estrogen receptor modulator, was discovered by multiple ligand simultaneous docking and drug repositioning approaches to have a novel function as an IL-6/GP130 target inhibitor. bazedoxifene 0-12 interleukin 6 Homo sapiens 198-202 15941782-4 2005 In the present study, we demonstrated that preexposure of U937 macrophage-like cells to sodium lactate increased LPS-stimulated matrix metalloproteinase (MMP)-1, IL-1beta, and IL-6 secretion. Sodium Lactate 88-102 interleukin 6 Homo sapiens 176-180 29777330-3 2018 Bazedoxifene (BZA), a third-generation selective estrogen receptor modulator, was discovered by multiple ligand simultaneous docking and drug repositioning approaches to have a novel function as an IL-6/GP130 target inhibitor. bazedoxifene 14-17 interleukin 6 Homo sapiens 198-202 29777330-15 2018 Further mechanistic studies determined that BZA treatment enhanced 5-FU anti-tumor activation by inhibiting the IL-6/GP130 signaling pathway and the phosphorylation status of the downstream effectors AKT, ERK and STAT3. bazedoxifene 44-47 interleukin 6 Homo sapiens 112-116 29197622-4 2018 Mechanistic study showed that dioscin significantly up-regulated the expression levels of Sirt3, SOD2, and then suppressed inflammation by decreasing the expression levels of NF-kB, HMGB1, c-Jun, c-Fos, COX2, TNF-alpha, IL-1beta and IL-6. dioscin 30-37 interleukin 6 Homo sapiens 233-237 15941782-8 2005 Results showed that blocking of either NF-kappaB or MAPK pathways led to the inhibition of MMP-1, IL-1beta, and IL-6 expression stimulated by sodium lactate, LPS, or both. Sodium Lactate 142-156 interleukin 6 Homo sapiens 112-116 28592206-3 2018 Three different DNA aptamers and their interactions with IL6 protein were extensively investigated in a phosphate buffed saline (PBS) solution. phosphate buffed saline 104-127 interleukin 6 Homo sapiens 57-60 29307283-12 2018 Validation in human serum revealed markedly reduced IL-6 cytokine levels in MS patients taking low-dose naltrexone relative to standard care. Naltrexone 104-114 interleukin 6 Homo sapiens 52-56 16219540-5 2005 Afterwards, a statistical analysis of the two-level factorial designs revealed that in the presence of TPO, MK maturation was significantly stimulated by stem cell factor (SCF), interleukin (IL)-6, and IL-9, whereas Flt-3 ligand (FL) had a positive effect only on the expansion of MK progenitors. (2,4,6-trimethylbenzoyl) diphenylphosphine oxide 103-106 interleukin 6 Homo sapiens 178-196 29659888-13 2018 Trends toward decreases in interleukin-6 (P = 0.10) and high-sensitivity C-reactive protein (P = 0.10) were also seen with eplerenone vs placebo. Eplerenone 123-133 interleukin 6 Homo sapiens 27-40 29399191-0 2018 Effects of flurbiprofen on serum level of interleukin-6, prostacyclin and corticosteroid A2 in patients with bone metastases of cancer. Flurbiprofen 11-23 interleukin 6 Homo sapiens 42-55 15869467-11 2005 Thus 3-hydroxy-PGE2 induced interleukin-6 gene expression via the EP3 receptor (PGE2 receptor 3) in A549 cells, and raised cAMP levels via the EP4 receptor in Jurkat cells. 3-hydroxy-pge2 5-19 interleukin 6 Homo sapiens 28-41 29399191-1 2018 The present study aimed to investigate the effects of flurbiprofen on serum level of interleukin-6 (IL-6), prostacyclin (PGI2) and corticosteroid A2 (TXA2) in patients with bone metastases of cancer. Flurbiprofen 54-66 interleukin 6 Homo sapiens 85-98 29399191-1 2018 The present study aimed to investigate the effects of flurbiprofen on serum level of interleukin-6 (IL-6), prostacyclin (PGI2) and corticosteroid A2 (TXA2) in patients with bone metastases of cancer. Flurbiprofen 54-66 interleukin 6 Homo sapiens 100-104 29737177-1 2018 The lactone derivative of the epoxyisoprostane EC is a highly effective inhibitor of the secretion of the proinflammatory cytokine IL-6. epoxyisoprostane 30-46 interleukin 6 Homo sapiens 131-135 16045524-9 2005 RESULTS: Dydrogesterone significantly inhibited the production of the Th1 cytokines IFN-gamma (P= 0.0001) and TNF-alpha (P= 0.005) and induced an increase in the levels of the Th2 cytokines IL-4 (P= 0.03) and IL-6 (P= 0.017) resulting in a substantial shift in the ratio of Th1/Th2 cytokines. Dydrogesterone 9-23 interleukin 6 Homo sapiens 209-213 29766980-14 2018 Moreover, the ripasudil treatment also inhibited the nuclear translocation of NF-kappaB and further suppressed the levels of interleukin (IL) 6 and tumor necrosis factor (TNF) alpha. K-115 14-23 interleukin 6 Homo sapiens 125-143 29568569-5 2018 Results: One such material, synthesized from chondroitin sulfate type A and serotonin in the presence of Cu2+ was found to affect the release of IL-1beta and IL-6 cytokines from immune cells. cupric ion 105-109 interleukin 6 Homo sapiens 158-162 16045524-12 2005 CONCLUSION: Dydrogesterone inhibits the production of the Th1 cytokines IFN-gamma and TNF-alpha from lymphocytes and up-regulates the production of the Th2 cytokines IL-4 and IL-6, inducing a Th1 to Th2 cytokine shift. Dydrogesterone 12-26 interleukin 6 Homo sapiens 175-179 30068872-11 2018 Furthermore, DBM effectively inhibited the expression of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1beta), IL-6, and monocyte chemoattractant protein-1 (MCP-1). dibenzoylmethane 13-16 interleukin 6 Homo sapiens 164-168 29610530-2 2018 We now demonstrate that exposure of cobalt and chromium NPs to BeWo cell barriers, an in vitro model of the human placenta, triggers impairment of the autophagic flux and release of interleukin-6. Chromium 47-55 interleukin 6 Homo sapiens 182-195 15878691-7 2005 In macrophages, acetaminophen decreased the secretion of TNF-alpha (at 4 and 24 h, concentration-related) and IL-6 (at 24 h, at 0.1 mM), and did not affect significantly IL-8 production. Acetaminophen 16-29 interleukin 6 Homo sapiens 110-114 29849500-7 2018 The result showed that CBT effectively suppressed the expressions of TNF-alpha, IL-6, MCP-1, and IL-1beta in a dose-dependent manner and significantly downregulated 19 out of 32 differentially expressed genes, most of which were involved in the NOD1/NF-kappaB pathway, and also showed that CBT remarkably inhibited LPS-induced NOD1, RIP2, and NF-kappaB activation. columbianetin 23-26 interleukin 6 Homo sapiens 80-84 30205401-7 2018 RESULTS: We observed a significant increase in IL-6, IL-18, and MPO levels in CRS type 1 group compared to AHF (p < 0.001). Chromium 78-81 interleukin 6 Homo sapiens 47-51 15878691-8 2005 These in vitro observations demonstrate that clinically relevant concentrations of acetaminophen decreased: (i) intracellular GSH in human pulmonary macrophages and type II pneumocytes and (ii) the secretion of TNF-alpha and possibly IL-6 by human pulmonary macrophages. Acetaminophen 83-96 interleukin 6 Homo sapiens 234-238 29727764-9 2018 Significant positive correlation was shown between HADS-D and IL-6 (r = 0.1729, p = 0.004). Dapsone hydroxylamine 51-55 interleukin 6 Homo sapiens 62-66 29397417-4 2018 The terminal ileum IFN-gamma, IL-6, and IL-1beta were elevated in CD-new, while in the colon, the IFN-gamma, IL-17A, and IL-6 were elevated in both CD-new and CD-treated subgroups. cd-new 66-72 interleukin 6 Homo sapiens 30-34 16118573-9 2005 CONCLUSION: CHO compared to PLA beverage ingestion attenuated the increase in plasma cortisol, epinephrine, IL-6, IL-10, and IL-1ra, but not muscle IL-6, IL-8, and TNF-alpha mRNA in athletes cycling 2.5 h at 60% Wmax. CAV protocol 12-15 interleukin 6 Homo sapiens 108-112 29256007-5 2018 RESULTS: IL-1beta decreased genomic methylation of human intestinal epithelial cells and induced demethylation at cg-specific sites at the promoter of pro-inflammatory genes IL6 and IL8; conversely it did not change the methylation of the IL10 promoter. cysteinylglycine 114-116 interleukin 6 Homo sapiens 174-177 29393468-0 2018 Saffron carotenoids inhibit STAT3 activation and promote apoptotic progression in IL-6-stimulated liver cancer cells. saffron carotenoids 0-19 interleukin 6 Homo sapiens 82-86 29055264-8 2018 Paroxetine treatment increased the levels of proinflammatory cytokines IFN-gamma, TNF-alpha, and IL-6 and decreased Th2 cytokine levels. Paroxetine 0-10 interleukin 6 Homo sapiens 97-101 29055264-9 2018 After paroxetine treatment, IL-6 levels increased more in the non-remitter group than in the remitter group. Paroxetine 6-16 interleukin 6 Homo sapiens 28-32 15878941-4 2005 After ARVM were exposed to IL-6 for 2-24 h, intracellular cGMP contents were time dependently increased; this was mimicked by a NO donor and abolished by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), an inhibitor of soluble guanylyl cyclase (sGC), or Rp-8-Br-cGMP, an inhibitor of cGMP-dependent protein kinase G (PKG). 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one 154-197 interleukin 6 Homo sapiens 27-31 29276186-6 2017 The IL-6/IL-10 ratio significantly correlated with BEBS score. bebs 51-55 interleukin 6 Homo sapiens 4-8 29796304-1 2018 Aim: An electrochemical urine dipstick probe biosensor has been demonstrated using molybdenum electrodes on nanoporous polyamide substrate for the quantitative detection of two inflammatory protein biomarkers, CRP and IL-6. Nylons 119-128 interleukin 6 Homo sapiens 218-222 15878941-4 2005 After ARVM were exposed to IL-6 for 2-24 h, intracellular cGMP contents were time dependently increased; this was mimicked by a NO donor and abolished by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), an inhibitor of soluble guanylyl cyclase (sGC), or Rp-8-Br-cGMP, an inhibitor of cGMP-dependent protein kinase G (PKG). 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one 199-202 interleukin 6 Homo sapiens 27-31 29087023-3 2017 Rank correlation analysis revealed that interleukin 6 expression exhibited significant positive correlations with urinary sodium (R = .13) and sodium to potassium ratio (R = .13). Potassium 153-162 interleukin 6 Homo sapiens 40-53 15843504-8 2005 Also, levels of hk-SE-induced IL-10 and IL-6 secretion were increased at lower lead doses. hk-se 16-21 interleukin 6 Homo sapiens 40-44 30647695-9 2017 On the other hand, Se and GLY reduced hydrogen peroxide-mediated production of TNF-alpha, IL-1, IL-6 and expression of iNOS and NF-kappaB. Selenium 19-21 interleukin 6 Homo sapiens 96-100 29713361-4 2018 AGNE reduced histamine secretion, production of proinflammatory cytokines including interleukin- (IL-) 1beta, IL-4, IL-6, IL-8, and IL-10, and expression of cyclooxygenase- (COX-) 2 in HMC-1 cells. agne 0-4 interleukin 6 Homo sapiens 116-120 29345344-6 2018 Pam2Cys challenge, compared to Pam3Cys, induced PTB and promoted significantly higher expression of inflammatory cytokines, specifically IL-6 and IFN-beta, both in vivo and in vitro. S-(2,3-bis(palmitoyloxy)propyl)cysteine 0-7 interleukin 6 Homo sapiens 137-141 29196668-4 2017 We also confirmed that treatment with methoxamine hydrochloride activates the signal transducer and activator of transcription 3 (STAT3) pathway downstream of IL-6 family cytokines including OsM. Methoxamine 38-63 interleukin 6 Homo sapiens 159-163 15855050-6 2005 The early loss of ascorbate correlated with duration of CPB (P < 0.002, r = 0.72), plasma hemoglobin after cross-clamp removal (P < 0.001, r = 0.70), and IL-6 and IL-8 levels at 24 and 48 h after CPB (P < 0.01), but not with postoperative lactate levels, strongly suggesting that hemolysis, and not inflammation or ischemia, was the main cause of early oxidative stress. Ascorbic Acid 18-27 interleukin 6 Homo sapiens 160-164 29209219-12 2017 In TNFalpha-primed RAFLS the super-production of IL-8 and IL-6 induced by LPA occurs mainly via MSK-independent pathways, and simultaneous inhibition of at least two MAPK signaling pathways was required to block their synthesis. lysophosphatidic acid 74-77 interleukin 6 Homo sapiens 58-62 29209219-13 2017 Since simultaneous inhibition of both the p38MAPK and ERK-MSK-CREB pathways are required to significantly reduce LPA-mediated IL-8 and IL-6 production in TNFalpha-preconditioned RAFLS, drug combinations targeting these two pathways are potential new strategies to treat rheumatoid arthritis. lysophosphatidic acid 113-116 interleukin 6 Homo sapiens 135-139 29335340-10 2018 Cit-ME, a genuine ligand of ACPA, inhibited the ACPA-induced upregulation of IL-1beta and IL-6 by 30%. cit-me 0-6 interleukin 6 Homo sapiens 90-94 15769552-1 2005 As we have shown earlier, the stable adenosine analogue NECA (N6-(R)-phenylisopropyladenosine) stimulates IL-6 expression in the human astrocytoma cell line U373 MG via the A(2b) receptor. Adenosine-5'-(N-ethylcarboxamide) 56-60 interleukin 6 Homo sapiens 106-110 29107850-5 2018 The increase of interleukin-6 during the 24h after implantation was associated with higher levels of pentadecanoic acid (C15:0) and lower levels of alpha-linolenic acid (C18:3 N3). alpha-Linolenic Acid 148-168 interleukin 6 Homo sapiens 16-29 15714504-6 2005 A significant reduction in IL-6 secretion was also observed with the other silicate- and zinc phosphate-based glasses tested. zinc phosphate 89-103 interleukin 6 Homo sapiens 27-31 29245047-5 2018 Moreover, pretreatment with AG490, a Janus kinase (JAK) inhibitor, inhibited polyI:C-induced STAT3 phosphorylation and subsequent IL-6 and IL-8 release. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 28-33 interleukin 6 Homo sapiens 130-134 29138596-5 2017 Studies of the mechanism of action of nifuratel indicated that it acts by inhibiting the constitutive and interleukin-6-induced STAT3 activation. Nifuratel 38-47 interleukin 6 Homo sapiens 106-119 28821038-3 2017 The results indicated NACOS significantly suppressed the LPS-induced pro-inflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) expression. nacos 22-27 interleukin 6 Homo sapiens 96-109 28821038-3 2017 The results indicated NACOS significantly suppressed the LPS-induced pro-inflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) expression. nacos 22-27 interleukin 6 Homo sapiens 111-115 15901049-5 2005 Significantly decreased concentrations of beta2-MG, IL-6 and total protein were found in both BAP and BP. benzylaminopurine 94-97 interleukin 6 Homo sapiens 52-56 28711499-0 2017 Inhibition of IL-6/STAT3 signaling in human cancer cells using Evista. Raloxifene Hydrochloride 63-69 interleukin 6 Homo sapiens 14-18 28711499-5 2017 Our previous study found that Raloxifene inhibited IL-6/GP130 interaction, resulting in blockade of STAT3 phosphorylation. Raloxifene Hydrochloride 30-40 interleukin 6 Homo sapiens 51-55 29207075-6 2018 The FDA-approved drug bazedoxifene, a blocker of the formation of the hexameric IL-6/IL-6R/GP130 complex, was re-purposed in this study to inhibit the IL-6/GP130/STAT3 signaling pathway. bazedoxifene 22-34 interleukin 6 Homo sapiens 80-84 29207075-6 2018 The FDA-approved drug bazedoxifene, a blocker of the formation of the hexameric IL-6/IL-6R/GP130 complex, was re-purposed in this study to inhibit the IL-6/GP130/STAT3 signaling pathway. bazedoxifene 22-34 interleukin 6 Homo sapiens 85-89 29207075-7 2018 Bazedoxifene not only inhibited IL-6 mediated cell viability and cell proliferation, and increased phosphorylated STAT3 expression, but it also decreased cell glycolysis, demonstrating a certain level of therapeutic efficacy in vitro. bazedoxifene 0-12 interleukin 6 Homo sapiens 32-36 29465583-8 2018 However, in the LHTL group, changes in plasma glucagon-like peptide-1 (GLP-1) and interleukin-6 (IL-6) levels, positively correlated with each other (r = 0.708, P = .015) but negatively with BW changes (r = -0.608, P = .027 and r = -0.518, P = .048, respectively). lhtl 16-20 interleukin 6 Homo sapiens 82-95 29465583-8 2018 However, in the LHTL group, changes in plasma glucagon-like peptide-1 (GLP-1) and interleukin-6 (IL-6) levels, positively correlated with each other (r = 0.708, P = .015) but negatively with BW changes (r = -0.608, P = .027 and r = -0.518, P = .048, respectively). lhtl 16-20 interleukin 6 Homo sapiens 97-101 29465583-9 2018 CONCLUSION: The results indicated that LHTL could induce more weight loss safely and efficiently as compared to LLTL and increase the plasma GLP-1 levels that may be mediated by IL-6 to rebalance the appetite. lhtl 39-43 interleukin 6 Homo sapiens 178-182 28711499-6 2017 In our present study, we examined the effect on IL-6/GP130/STAT3 signaling pathway and cancer cell viability with Evista. Raloxifene Hydrochloride 114-120 interleukin 6 Homo sapiens 48-52 28711499-8 2017 Evista also inhibited phosphorylation of STAT3 induced by IL-6 in MCF-7, HT29 and MM.1S cancer cell lines. Raloxifene Hydrochloride 0-6 interleukin 6 Homo sapiens 58-62 28711499-12 2017 These results suggest that it may be possible for Evista to emerge as a chemoprevention agent for breast cancer and other cancers such as colon cancer or multiple myeoloma by targeting IL-6/STAT3 signaling. Raloxifene Hydrochloride 50-56 interleukin 6 Homo sapiens 185-189 16895664-4 2005 Calcineurin inhibitors, cyclosporine and tacrolimus, are involved in tumor development through various mechanisms: they promote B-cell proliferation by increasing T lymphocyte IL6 secretion, decrease DNA repair ability and may be able to promote metastasis spreading by a direct cellular effect that is independent of their effect on the host"s immune cells. Tacrolimus 41-51 interleukin 6 Homo sapiens 176-179 28547650-9 2017 Exposure to Leu-Leu-OMe significantly promoted the production of IL-6 and IL-8 in primed HUVECs; this effect was prevented by the pre-treatment of cells with an IL-1RA. leucyl-leucine-methyl ester 12-23 interleukin 6 Homo sapiens 65-69 28510700-9 2017 Furthermore, GPLE significantly inhibited the production of TNF-alpha and IL-6 cytokines compared with PLE in phorbol 12-myristate 13-acetate (PMA) plus A23187-stimulated HMC-1 human mast cells. gple 13-17 interleukin 6 Homo sapiens 74-78 28941582-4 2018 Topical application of the strong contact sensitizer 2,4-dinitrochlorobenzene (DNCB) induced IL-6 and IL-8 secretion in RHS with LC-like cells, whereas no change was observed in reference models. Dinitrochlorobenzene 53-77 interleukin 6 Homo sapiens 93-97 28941582-4 2018 Topical application of the strong contact sensitizer 2,4-dinitrochlorobenzene (DNCB) induced IL-6 and IL-8 secretion in RHS with LC-like cells, whereas no change was observed in reference models. Dinitrochlorobenzene 79-83 interleukin 6 Homo sapiens 93-97 15472138-3 2005 Under the normoxic condition, adenosine and its stable analog, 5"-(N-ethylcarboxamido)-adenosine, via activation of A2B adenosine receptors, increased the release of interleukin (IL)-6 by 14-fold and induced the differentiation of human lung fibroblasts to myofibroblasts. Adenosine-5'-(N-ethylcarboxamide) 63-96 interleukin 6 Homo sapiens 166-184 29441018-9 2018 Asiaticoside also significantly downregulated the elevated expressions of TNF-alpha, IL-6, TLR4, MyD88, TRAF6, and p-NF-kappaB p65, as well as inhibited NF-kappaB p65 translocation from cytoplasm to nucleus induced by Abeta1-42 in hBMECs in a concentration-dependent manner. asiaticoside 0-12 interleukin 6 Homo sapiens 85-89 28871940-5 2017 Results The expressions of IL-2 and IL-6 in the AR group were significantly higher than those in the STA group after the peripheral blood lymphocytes were stimulated. Argon 48-50 interleukin 6 Homo sapiens 36-40 15472138-4 2005 This latter effect of 5"-(N-ethylcarboxamido)-adenosine was abolished by an IL-6-neutralizing antibody. Adenosine-5'-(N-ethylcarboxamide) 22-55 interleukin 6 Homo sapiens 76-80 15747315-11 2004 Two hours after the end of the treatments the IL-6 levels tend to grow in both methods, but numerically less in HDF-OL without acetate; the difference verges on meaningfulness. Acetates 127-134 interleukin 6 Homo sapiens 46-50 28744288-0 2017 Naltrexone Inhibits IL-6 and TNFalpha Production in Human Immune Cell Subsets following Stimulation with Ligands for Intracellular Toll-Like Receptors. Naltrexone 0-10 interleukin 6 Homo sapiens 20-24 28744288-3 2017 We analyzed the effects of naltrexone hydrochloride on IL-6 secretion by peripheral blood mononuclear cells (PBMC) in vitro following stimulation with ligands for TLR4 and for the intracellular receptors TLR7, TLR8, and TLR9. Naltrexone 27-51 interleukin 6 Homo sapiens 55-59 28744288-5 2017 Intracellular staining demonstrated that naltrexone inhibited production of IL-6 and TNFalpha by monocyte and plasmacytoid dendritic cell subsets within the PBMC population following treatment with ligands for TLR7/8 and TLR9, respectively. Naltrexone 41-51 interleukin 6 Homo sapiens 76-80 28744288-7 2017 Additionally, naltrexone inhibited IL-6 production in isolated monocytes and B cells after TLR7/8 and TLR9 stimulation, respectively, but no effect on IL-6 production in isolated monocytes after TLR4 stimulation was observed. Naltrexone 14-24 interleukin 6 Homo sapiens 35-39 29854980-11 2018 At 12 hours postdose, apabetalone countered the activation of pathways associated with renal disease and reduced the abundance of disease markers, including interleukin-6, plasminogen activator inhibitor-1, and osteopontin. apabetalone 22-33 interleukin 6 Homo sapiens 157-170 15799170-0 2004 Changes in serum interleukin-6 and high-sensitivity C-reactive protein levels in patients with acute coronary syndrome and their responses to simvastatin. Simvastatin 142-153 interleukin 6 Homo sapiens 17-30 28884894-7 2017 In addition, CDP-choline avoided the oxidative damage of mtDNA and inhibited the release of the interleukins IL-1 and IL6, recognized as markers of acute inflammatory reaction. Cytidine Diphosphate Choline 13-24 interleukin 6 Homo sapiens 118-121 29164569-14 2017 was positively correlated with the levels of IL-6, IL-17, IL-22, and IL-33, while the number of Bifidobacteria and Bacillus lactic acid was negatively correlated with the levels of IL-6, IL-17, IL-22, and IL-33. bacillus lactic acid 115-135 interleukin 6 Homo sapiens 181-185 28632755-7 2017 To confirm its importance we performed a series of in vitro experiments, in which we demonstrated that potassium levels a increased the virulence of the oral community as a whole and at the same time altering the immune response of gingival epithelium, increasing the production of TNF-alpha and reducing the expression of IL-6 and the antimicrobial peptide human beta-defensin 3 (hBD-3). Potassium 103-112 interleukin 6 Homo sapiens 323-327 28402673-12 2017 In conclusion, ACL enhances the therapeutic and anticancer efficacy of MTX, when coencapsulated into fucose-anchored LPHNPs, as confirmed by cell viability and serum angiogenesis (IL-6, TNF-alpha, IL-1beta, COX2, and MMP1) at both transcript and proteome level. Fucose 101-107 interleukin 6 Homo sapiens 180-184 15799170-7 2004 After 3 weeks of treatment with simvastatin, the serum IL-6, hs-CRP, total cholesterol, and low-density lipoprotein cholesterol levels were decreased significantly in the simvastatin group (P < 0.001), but no significant changes were observed in the routine group. Simvastatin 32-43 interleukin 6 Homo sapiens 55-59 15799170-7 2004 After 3 weeks of treatment with simvastatin, the serum IL-6, hs-CRP, total cholesterol, and low-density lipoprotein cholesterol levels were decreased significantly in the simvastatin group (P < 0.001), but no significant changes were observed in the routine group. Simvastatin 171-182 interleukin 6 Homo sapiens 55-59 28430601-0 2017 Growth-suppressive activity of raloxifene on liver cancer cells by targeting IL-6/GP130 signaling. Raloxifene Hydrochloride 31-41 interleukin 6 Homo sapiens 77-81 28430601-4 2017 We reported the discovery of EVISTA (Raloxifene HCl) as novel inhibitor of IL-6/GP130 protein-protein interactions (PPIs) using multiple ligand simultaneous docking (MLSD) and drug repositioning. Raloxifene Hydrochloride 29-35 interleukin 6 Homo sapiens 75-79 29118922-7 2017 Furthermore, pre-treatment with the Janus kinase 2 (JAK2) inhibitor AG490 abolished the IL-6-induced SDCBP expression, suggesting that the effect of IL-6 on SDCBP transcription is dependent on JAK2/signal transducer and activator of transcription 3 (STAT3) signaling. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 68-73 interleukin 6 Homo sapiens 88-92 29118922-7 2017 Furthermore, pre-treatment with the Janus kinase 2 (JAK2) inhibitor AG490 abolished the IL-6-induced SDCBP expression, suggesting that the effect of IL-6 on SDCBP transcription is dependent on JAK2/signal transducer and activator of transcription 3 (STAT3) signaling. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 68-73 interleukin 6 Homo sapiens 149-153 15210834-6 2004 Similarly, although treatment of HGFs with BAPTA-AM [1,2-bis(O-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid-acetoxymethyl ester], an intracellular Ca(2+) chelator, markedly attenuated the thrombin-induced increase in intracellular Ca(2+) concentration, the same treatment did not suppress the thrombin-induced IL-6 production. 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 43-51 interleukin 6 Homo sapiens 312-316 27771020-8 2017 Four trials (one with oligofructose-enriched inulin, one with inulin and two with different synbiotics) showed a reduction on interleukin-6 and/or tumor necrosis factor. oligofructose 22-35 interleukin 6 Homo sapiens 126-139 28849137-5 2017 Furthermore, NW-PM2.5 and W-PM2.5 significantly reduced sebaceous lipid synthesis and markedly promoted the production of inflammatory cytokines, including interleukin-1alpha (IL-1alpha), IL-6 and IL-8 in SZ95 sebocytes. nw-pm2 13-19 interleukin 6 Homo sapiens 188-192 28849137-5 2017 Furthermore, NW-PM2.5 and W-PM2.5 significantly reduced sebaceous lipid synthesis and markedly promoted the production of inflammatory cytokines, including interleukin-1alpha (IL-1alpha), IL-6 and IL-8 in SZ95 sebocytes. w-pm2 14-19 interleukin 6 Homo sapiens 188-192 27738972-2 2017 PURPOSE: This study was conducted to investigate interactions of SES and the Five-Factor Model (FFM) personality traits in predicting circulating concentrations of the inflammatory markers interleukin-6 (IL-6) and C-reactive protein (CRP). Selenium 65-68 interleukin 6 Homo sapiens 189-202 27738972-4 2017 RESULTS: SES interacted with conscientiousness to predict levels of IL-6 (interaction b = .03, p = .002) and CRP (interaction b = .04, p = .014) and with neuroticism to predict IL-6 (interaction b = -.03, p = .004). Selenium 9-12 interleukin 6 Homo sapiens 68-72 27738972-4 2017 RESULTS: SES interacted with conscientiousness to predict levels of IL-6 (interaction b = .03, p = .002) and CRP (interaction b = .04, p = .014) and with neuroticism to predict IL-6 (interaction b = -.03, p = .004). Selenium 9-12 interleukin 6 Homo sapiens 177-181 27738972-7 2017 Viewed from the perspective of SES as the moderator, neuroticism was positively related to IL-6 at low levels of SES but negatively related at high SES. Selenium 31-34 interleukin 6 Homo sapiens 91-95 27738972-7 2017 Viewed from the perspective of SES as the moderator, neuroticism was positively related to IL-6 at low levels of SES but negatively related at high SES. Selenium 113-116 interleukin 6 Homo sapiens 91-95 27738972-7 2017 Viewed from the perspective of SES as the moderator, neuroticism was positively related to IL-6 at low levels of SES but negatively related at high SES. Selenium 113-116 interleukin 6 Homo sapiens 91-95 15210834-6 2004 Similarly, although treatment of HGFs with BAPTA-AM [1,2-bis(O-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid-acetoxymethyl ester], an intracellular Ca(2+) chelator, markedly attenuated the thrombin-induced increase in intracellular Ca(2+) concentration, the same treatment did not suppress the thrombin-induced IL-6 production. 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 53-129 interleukin 6 Homo sapiens 312-316 15271375-4 2004 RESULTS: Vitamin C dose dependently inhibited the LPS-induced number of monocytes producing IL-6 (e.g., 41.0% reduction, p < 0.001, 20 mM vitamin C) and TNF-alpha (e.g., 26.0% reduction, p < 0.005, 20 mM vitamin C). Ascorbic Acid 9-18 interleukin 6 Homo sapiens 92-96 29230410-5 2017 This work aimed at (i) determining the HDL, Apo A1, LDL, and VLDL concentrations in ZVL patients" sera; (ii) investigating the oxidative effect of ZVL patients" sera on the beta-carotene matrix; (iii) measuring IL-10, IL-6, IL-12p40, and tumour necrosis factor-alpha (TNF-alpha) concentrations in the macrophage cultures, to which 10% of ZVL patients" serum had been added. beta Carotene 173-186 interleukin 6 Homo sapiens 218-222 28955228-13 2017 AOS treatment resulted in the increase in serum levels of SOD, GSH, HDL-C, and reduction in the levels of interleukin-1 (IL-1) beta and IL-6; the ratios of AST/ALT; and triglycerides, total cholesterol (TC), low-density lipoprotein cholesterol LDL-C, and malondialdehyde (MDA) (P < 0.05). D-(+)-ALLOSE 0-3 interleukin 6 Homo sapiens 136-140 15271375-4 2004 RESULTS: Vitamin C dose dependently inhibited the LPS-induced number of monocytes producing IL-6 (e.g., 41.0% reduction, p < 0.001, 20 mM vitamin C) and TNF-alpha (e.g., 26.0% reduction, p < 0.005, 20 mM vitamin C). Ascorbic Acid 141-150 interleukin 6 Homo sapiens 92-96 15129368-4 2004 In addition, PD098059 as well as simvastatin and the FTase inhibitor abolished alkaline phosphatase activity and/or osteocalcin mRNA induction by the IL-6/IL-6sR in these cells. Simvastatin 33-44 interleukin 6 Homo sapiens 150-154 28887458-7 2017 Inhibition of 15-PGDH using either indomethacin or SW033291 significantly reduced the further conversion of 15-epi-LXA4 and MaR1 and regulated expression of IL-6, PDPN and STAT-1. Indomethacin 35-47 interleukin 6 Homo sapiens 157-161 27640899-9 2017 The suppressive effect of fluoxetine on IL-6 was attenuated by knockdown of TNFAIP3 expression. Fluoxetine 26-36 interleukin 6 Homo sapiens 40-44 28367199-10 2017 OSAHS group had significantly higher serum levels of IL-4, IL-6, IL-10 and IFN-gamma than those of control group (P<0.05), but their IL-2 and TNF-alpha levels were similar (P>0.05). osahs 0-5 interleukin 6 Homo sapiens 59-63 15129368-4 2004 In addition, PD098059 as well as simvastatin and the FTase inhibitor abolished alkaline phosphatase activity and/or osteocalcin mRNA induction by the IL-6/IL-6sR in these cells. Simvastatin 33-44 interleukin 6 Homo sapiens 155-159 15169848-0 2004 Supplementation with vitamins C and E inhibits the release of interleukin-6 from contracting human skeletal muscle. Ascorbic Acid 21-31 interleukin 6 Homo sapiens 62-75 27665471-0 2016 The reduction of IL-6 gene expression, pAKT, pERK1/2, pSTAT3 signaling pathways and invasion activity by gallic acid in prostate cancer PC3 cells. Gallic Acid 105-116 interleukin 6 Homo sapiens 17-21 27665471-10 2016 The level of IL-6 and its gene expression decreased significantly in PC3 cells treated with GA. Gallic Acid 92-94 interleukin 6 Homo sapiens 13-17 15169848-15 2004 In conclusion, our results show that supplementation with vitamins C and E attenuated the systemic IL-6 response to exercise primarily via inhibition of the IL-6 protein release from the contracting skeletal muscle per se. Ascorbic Acid 58-68 interleukin 6 Homo sapiens 99-103 27748636-8 2016 However twelve genes were were differently regulated by the two compounds: interleukins (IL) IL-1B, IL-6 and a chemokine CCL22 were upregulated by HIX and significantly supressed by Leflunomide. Leflunomide 182-193 interleukin 6 Homo sapiens 100-104 27745982-10 2016 CONCLUSIONS: The treatment of HNC patients with concurrent CTRT induces a significant increase in the salivary levels of IL-1beta, IL-6, and tumor necrosis factor-alpha, all positively associated with the severity of mucosal toxicity. ctrt 59-63 interleukin 6 Homo sapiens 131-135 15169848-15 2004 In conclusion, our results show that supplementation with vitamins C and E attenuated the systemic IL-6 response to exercise primarily via inhibition of the IL-6 protein release from the contracting skeletal muscle per se. Ascorbic Acid 58-68 interleukin 6 Homo sapiens 157-161 15235923-14 2004 Monocytes or neutrophils exposed to urate crystals produce tumor necrosis factor alpha, interleukin-1 (IL-1), IL-6, and IL-8. Uric Acid 36-41 interleukin 6 Homo sapiens 110-114 27613828-0 2016 Human astrocytes secrete IL-6 to promote glioma migration and invasion through upregulation of cytomembrane MMP14. cytomembrane 95-107 interleukin 6 Homo sapiens 25-29 27613828-10 2016 Taken together, our results indicated that cytomembrane MMP14 was induced by IL-6 secreted from astrocytes, thereby enhancing the migration and invasion of glioma cells through activation of MMP2. cytomembrane 43-55 interleukin 6 Homo sapiens 77-81 14975242-3 2004 Here we demonstrate that expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in MM cells and its agonists 15-d-PGJ2 and troglitazone completely abolished IL-6-inducible MM cell proliferation and induced apoptosis through affecting expression of multiple cell cycle or apoptosis genes, whereas PPARgamma antagonist GW9662 and PPARalpha agonist WY14643 did not display this inhibitory effect. 2-chloro-5-nitrobenzanilide 337-343 interleukin 6 Homo sapiens 177-181 15373964-6 2004 Subsequently, recombinant tumor necrosis factor-alpha (TNF-alpha), IL-6 and other cytokines were also shown to cause fever and EPs are now termed pyrogenic cytokines. exophthalmos producing substance 127-130 interleukin 6 Homo sapiens 67-71 27593287-8 2016 Cr was positively correlated with both IL-6 and IL-8 release, while Si was only associated with the increase of IL-6. Chromium 0-2 interleukin 6 Homo sapiens 39-43 27290719-4 2016 Geraniin downregulated the protein and the mRNA level of typical cytokines of M1 macrophage, including tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6), indicating that geraniin can suppress typical mediators of M1 macrophage at the transcriptional level. Geraniin 185-193 interleukin 6 Homo sapiens 147-160 14733131-20 2003 Cultured human Muller cells expressed both VEGF and IL-6 mRNA and these expressions were augmented after the treatment of AGEs, while also acting as photosensitizers and accelerating the degradation of hyaluronic acid in vitro. Hyaluronic Acid 202-217 interleukin 6 Homo sapiens 52-56 27290719-4 2016 Geraniin downregulated the protein and the mRNA level of typical cytokines of M1 macrophage, including tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6), indicating that geraniin can suppress typical mediators of M1 macrophage at the transcriptional level. Geraniin 185-193 interleukin 6 Homo sapiens 162-166 27465323-2 2016 We described the clinical features of SLEAP, and discussed the feasibility of plasma exchange (PE) combined with glucocorticosteroids (GC) in short-term prognosis and possible mechanism in reducing serum inflammatory cytokine IL-6 and removing serum lipids. glucocorticosteroids 113-133 interleukin 6 Homo sapiens 226-230 14620928-6 2003 An HMG-CoA reductase inhibitor (mevastatin, 10 micromol/l) attenuated the PAI-1 production induced by IL-1beta and IL-6. mevastatin 32-42 interleukin 6 Homo sapiens 115-119 27181326-11 2016 The effect of IL-6 on the LCR, but not elevated body temperature, was blocked by pretreatment with indomethacin. Indomethacin 99-111 interleukin 6 Homo sapiens 14-18 19180800-4 2003 Purple bamboo salt (1 mg/mL) inhibited phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 secretion, by 67.04% +/- 0.08%, 68.01% +/- 1.85%, and 69.48% +/- 0.54%, respectively. Calcimycin 100-106 interleukin 6 Homo sapiens 180-184 27317992-4 2016 Mechanism study showed that dioscin significantly decreased the expression levels of IL-1beta, IL-6, TNF-alpha, IkappaBalpha, p50 and p65 through regulating TLR4/MyD88 pathway to rehabilitate inflammation. dioscin 28-35 interleukin 6 Homo sapiens 95-99 14567536-6 2003 Interleukin-6 and tumour necrosis factor-alpha levels increased in both patient groups, but were higher in paracetamol overdose. Acetaminophen 107-118 interleukin 6 Homo sapiens 0-46 27283230-10 2016 The upper 95th centile value for plasma IL-6 concentration in the healthy cohort (n=93) was 3 1 pg/mL, and 14% (36/249) of UCSF cohort and 26% (102/387) of the SARP cohort had plasma IL-6 concentrations above this upper limit. sarp 160-164 interleukin 6 Homo sapiens 40-44 27086282-5 2016 Moreover, lipoic acid or heat shock alone upregulated the IL-6 receptor (IL-6R-alpha) and glycoprotein 130 (gp130) mRNA expression followed by IL-6 expression; these data indicate that the regulation of lipoic acid or heat shock is mediated by IL-6R signaling, thus suggesting that C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 expression following lipoic acid treatment or heat shock. Thioctic Acid 10-21 interleukin 6 Homo sapiens 58-62 12826933-0 2003 Simvastatin inhibits interleukin-6 release in human monocytes stimulated by C-reactive protein and lipopolysaccharide. Simvastatin 0-11 interleukin 6 Homo sapiens 21-34 27086282-5 2016 Moreover, lipoic acid or heat shock alone upregulated the IL-6 receptor (IL-6R-alpha) and glycoprotein 130 (gp130) mRNA expression followed by IL-6 expression; these data indicate that the regulation of lipoic acid or heat shock is mediated by IL-6R signaling, thus suggesting that C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 expression following lipoic acid treatment or heat shock. Thioctic Acid 10-21 interleukin 6 Homo sapiens 73-77 27086282-5 2016 Moreover, lipoic acid or heat shock alone upregulated the IL-6 receptor (IL-6R-alpha) and glycoprotein 130 (gp130) mRNA expression followed by IL-6 expression; these data indicate that the regulation of lipoic acid or heat shock is mediated by IL-6R signaling, thus suggesting that C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 expression following lipoic acid treatment or heat shock. Thioctic Acid 203-214 interleukin 6 Homo sapiens 58-62 27086282-5 2016 Moreover, lipoic acid or heat shock alone upregulated the IL-6 receptor (IL-6R-alpha) and glycoprotein 130 (gp130) mRNA expression followed by IL-6 expression; these data indicate that the regulation of lipoic acid or heat shock is mediated by IL-6R signaling, thus suggesting that C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 expression following lipoic acid treatment or heat shock. Thioctic Acid 203-214 interleukin 6 Homo sapiens 73-77 27086282-5 2016 Moreover, lipoic acid or heat shock alone upregulated the IL-6 receptor (IL-6R-alpha) and glycoprotein 130 (gp130) mRNA expression followed by IL-6 expression; these data indicate that the regulation of lipoic acid or heat shock is mediated by IL-6R signaling, thus suggesting that C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 expression following lipoic acid treatment or heat shock. Thioctic Acid 203-214 interleukin 6 Homo sapiens 58-62 27086282-5 2016 Moreover, lipoic acid or heat shock alone upregulated the IL-6 receptor (IL-6R-alpha) and glycoprotein 130 (gp130) mRNA expression followed by IL-6 expression; these data indicate that the regulation of lipoic acid or heat shock is mediated by IL-6R signaling, thus suggesting that C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 expression following lipoic acid treatment or heat shock. Thioctic Acid 203-214 interleukin 6 Homo sapiens 73-77 12868677-13 2003 IL-6 levels appeared to correlate positively with bilirubin and gamma-GT levels and negatively with the degree of acidosis. Bilirubin 50-59 interleukin 6 Homo sapiens 0-4 26639033-6 2016 In vitro, statins decreased transcription and translation of IL-6 and collagen, with reversal via mevalonate. Mevalonic Acid 98-108 interleukin 6 Homo sapiens 61-65 27383709-5 2016 RESULTS: Budlein A inhibited MPO activity, IL-6, CXCL8, IL-10, and IL-12 production and induces neutrophil apoptosis. budlein A 9-18 interleukin 6 Homo sapiens 43-47 12595750-0 2003 Effect of interleukin 6 on the hepatic metabolism of itraconazole and its metabolite hydroxyitraconazole using primary human hepatocytes. hydroxyitraconazole 85-104 interleukin 6 Homo sapiens 10-23 27007849-8 2016 Inflammation and IL-6 production triggered by infection with Brucella abortus, which induces ER stress by injecting the type IV secretion system effector protein VceC into host cells, is TRAF2, NOD1/2 and RIP2-dependent and can be reduced by treatment with the ER stress inhibitor tauroursodeoxycholate or an IRE1alpha kinase inhibitor. ursodoxicoltaurine 281-302 interleukin 6 Homo sapiens 17-21 12499367-8 2003 We also demonstrate that a previously identified 14-amino acid histone H3-binding module of human CTF1/NF1, which is similar to synthetic ADs, can substitute for the HSF C-terminal activator in conferring temperature resistance and can mediate the modification of promoter chromatin structure. 14-amino acid histone 49-70 interleukin 6 Homo sapiens 166-169 27104513-8 2016 Gallic acid and chlorogenic acid could suppress the release of pro-inflammatory cytokine IL-6 and chemokine CCL7 and CXCL8, respectively, in IL-31- and IL-33-treated eosinophils-dermal fibroblasts co-culture; while berberine could suppress the release of IL-6, CXCL8, CCL2 and CCL7 in the eosinophil culture and eosinophils-dermal fibroblasts co-culture (all p < 0.05). Gallic Acid 0-11 interleukin 6 Homo sapiens 89-93 27104513-8 2016 Gallic acid and chlorogenic acid could suppress the release of pro-inflammatory cytokine IL-6 and chemokine CCL7 and CXCL8, respectively, in IL-31- and IL-33-treated eosinophils-dermal fibroblasts co-culture; while berberine could suppress the release of IL-6, CXCL8, CCL2 and CCL7 in the eosinophil culture and eosinophils-dermal fibroblasts co-culture (all p < 0.05). Gallic Acid 0-11 interleukin 6 Homo sapiens 255-259 12576215-6 2003 When DGHT (1mg/ml) was added, the secretion of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 was inhibited by 60.1, 81.8, 72.5%, respectively in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated HMC-1 cells. Calcimycin 227-233 interleukin 6 Homo sapiens 109-113 27079728-5 2016 Furthermore, interference of the Abeta-induced interaction of calcineurin with FOXO3 by decoy compounds significantly decreased amyloid-beta protein precursor (AbetaPP) synthesis, reduced the AbetaPP amyloidogenic pathway, resulting in lower Abeta levels, and blocked the expression of pro-inflammatory cytokines TNFalpha and IL-6 in astrocytes. UNII-042A8N37WH 33-38 interleukin 6 Homo sapiens 326-330 12571865-7 2003 RESULTS: Our data revealed that GD potently inhibits the production of TNFalpha, interleukin-6 (IL-6), and IL-1beta in activated macrophages. geldanamycin 32-34 interleukin 6 Homo sapiens 81-94 26934706-7 2016 Moreover, the production of IL-6 was significantly increased in rs2269067 GG cases compared to CG cases or CC cases (P = 0.002, P = 0.001, respectively). cysteinylglycine 95-97 interleukin 6 Homo sapiens 28-32 12571865-7 2003 RESULTS: Our data revealed that GD potently inhibits the production of TNFalpha, interleukin-6 (IL-6), and IL-1beta in activated macrophages. geldanamycin 32-34 interleukin 6 Homo sapiens 96-100 12571865-9 2003 Polysome profiles indicated that GD also inhibited the translation of TNFalpha and IL-6 transcripts. geldanamycin 33-35 interleukin 6 Homo sapiens 83-87 12235142-8 2002 Geldanamycin, an HSP90 inhibitor, markedly inhibited IL-6-stimulated STAT3 signaling in Hep3B hepatocytes cultured overnight at 39.5 degrees C as evaluated by DNA-shift assays, trafficking of PY-STAT3 to the nucleus, cross-precipitation of HSP90 by anti-STAT3 polyclonal antibody, and reporter/luciferase construct experiments. geldanamycin 0-12 interleukin 6 Homo sapiens 53-57 26912161-7 2016 RESULTS: ALA significantly decreased plasma TG, FFA, glycerol, IL-6, and TNF-alpha levels and increased the mRNA expression levels of PPAR-gamma, G0S2, and GPR120 in PBMC, compared with the untreated control group. alpha-Linolenic Acid 9-12 interleukin 6 Homo sapiens 63-67 12161055-8 2002 Partial correlation analyses of CRP and IL6 with other variables showed significant correlation of CRP with tHcy, and SA in patients with CHD only. thcy 108-112 interleukin 6 Homo sapiens 40-43 26857501-7 2016 In high, non-toxic concentrations all transition metals except Cr induced IL-8 and IL-6 production in microglia, with Ni and Co providing the strongest stimulation. Chromium 63-65 interleukin 6 Homo sapiens 83-87 26531764-8 2016 CONCLUSION: In our study, naive patients starting tenofovir/emtricitabine or abacavir/lamivudine plus efavirenz showed after 48 weeks a significant and comparable decrease in serum concentrations of IL-6, TNF-alpha, ICAM-1, VCAM-1, Eselectin and P-selectin, while the mean level of hs-CRP did not change significantly in any group. Emtricitabine 60-73 interleukin 6 Homo sapiens 199-203 26531764-8 2016 CONCLUSION: In our study, naive patients starting tenofovir/emtricitabine or abacavir/lamivudine plus efavirenz showed after 48 weeks a significant and comparable decrease in serum concentrations of IL-6, TNF-alpha, ICAM-1, VCAM-1, Eselectin and P-selectin, while the mean level of hs-CRP did not change significantly in any group. Lamivudine 86-96 interleukin 6 Homo sapiens 199-203 26531764-8 2016 CONCLUSION: In our study, naive patients starting tenofovir/emtricitabine or abacavir/lamivudine plus efavirenz showed after 48 weeks a significant and comparable decrease in serum concentrations of IL-6, TNF-alpha, ICAM-1, VCAM-1, Eselectin and P-selectin, while the mean level of hs-CRP did not change significantly in any group. efavirenz 102-111 interleukin 6 Homo sapiens 199-203 12117737-0 2002 Simvastatin reduces expression of cytokines interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 in circulating monocytes from hypercholesterolemic patients. Simvastatin 0-11 interleukin 6 Homo sapiens 44-57 12117737-4 2002 METHODS AND RESULTS: In this study, we asked whether simvastatin can influence in vitro and in vivo production of the proinflammatory cytokines interleukin (IL)-6, IL-8, and monocyte chemoattractant protein-1. Simvastatin 53-64 interleukin 6 Homo sapiens 144-162 12117737-7 2002 Furthermore, simvastatin decreased the expression of IL-6, IL-8, and monocyte chemoattractant protein-1 mRNA in peripheral blood mononuclear cells. Simvastatin 13-24 interleukin 6 Homo sapiens 53-57 27820923-4 2016 Exposure to 0.1, 1 and 10 ppm NO2 or synthetic air as a control was performed for 1 h. Subsequently, the cells were exposed to Der p 1 for 24 h. The release of interleukin (IL)-6 and IL-8 was measured by ELISA, and the production of IL-6 mRNA and IL-8 mRNA was measured by RT-PCR. Nitrogen Dioxide 30-33 interleukin 6 Homo sapiens 160-178 12187615-7 2002 At 30 min post-exercise, CHO versus PLA was associated with a higher plasma glucose concentration (p < .01), a lower plasma cortisol and IL-6 concentration (p < .02), and fewer numbers of circulating neutrophils (p < .05). CAV protocol 25-28 interleukin 6 Homo sapiens 140-144 26722359-6 2016 Stimulation with IL6 or IL4+LPS reversed the macrophages" increasing effect on the migration rate of MiaPaCa-2 completely and partly of HPAF-II. miapaca-2 101-110 interleukin 6 Homo sapiens 17-20 12187615-10 2002 These data indicate that CHO ingestion attenuates changes in plasma IL-6 concentration, neutrophil trafficking, and LPS-stimulated neutrophil degranulation in response to intermittent exercise that involves bouts of very high intensity exercise. CAV protocol 25-28 interleukin 6 Homo sapiens 68-72 11872747-9 2002 Prevention of IL-6-induced p70 activation and 4E-BP1 phosphorylation by the mammalian target of rapamycin inhibitors rapamycin and CCI-779 resulted in inhibition of IL-6-induced myeloma cell growth. temsirolimus 131-138 interleukin 6 Homo sapiens 14-18 27034587-0 2016 Klotho Contributes to Pravastatin Effect on Suppressing IL-6 Production in Endothelial Cells. Pravastatin 22-33 interleukin 6 Homo sapiens 56-60 28592636-10 2017 Pretreatment with IL-6 renders beta cells resistant to apoptosis induced by proinflammatory cytokines, and inhibition of autophagy with chloroquine prevents the ability of IL-6 to protect from apoptosis. Chloroquine 136-147 interleukin 6 Homo sapiens 172-176 26808720-9 2016 (R)-(+)-limonene derivatives decreased IL-6 production from normal cells in media with or without LPS (30.2% and 13.9%, respectively), while (-)-alpha-pinene derivatives induced IL-6 (verbenone had the strongest effect, 60.2% and 29.1% above control, respectively). alpha-pinene 141-157 interleukin 6 Homo sapiens 178-182 11872747-9 2002 Prevention of IL-6-induced p70 activation and 4E-BP1 phosphorylation by the mammalian target of rapamycin inhibitors rapamycin and CCI-779 resulted in inhibition of IL-6-induced myeloma cell growth. temsirolimus 131-138 interleukin 6 Homo sapiens 165-169 29084660-4 2017 The results showed that flurbiprofen can make the serum TNF- and IL-6 levels significantly reduce, illustrate the application of flurbiprofen axetil can promote the inflammatory balance, inhibit excessive stress reaction, thus contributing to the clinical curative effect and postoperative recovery of patients. Flurbiprofen 24-36 interleukin 6 Homo sapiens 65-69 12010778-4 2002 NS-398 (1 microM), a cyclo-oxygenase-2 (COX-2) inhibitor, inhibited IL-6 and VEGF production (35+/-4% and 26+/-2%, respectively) but enhanced M-CSF production (38+/-4%) by IL-1beta (1 ng ml(-1)) in synovial fibroblasts isolated from patients with osteoarthritis (OA) and rheumatoid arthritis (RA). N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 0-6 interleukin 6 Homo sapiens 68-72 11788581-0 2002 Function and molecular modeling of the interaction between human interleukin 6 and its HNK-1 oligosaccharide ligands. Oligosaccharides 93-108 interleukin 6 Homo sapiens 65-78 28351806-12 2017 Our results showed the strongest significant positive associations for IL-6 with MI, ST and TB in elderly people. Terbium 92-94 interleukin 6 Homo sapiens 71-75 26588227-6 2015 On the other hand, the gene expression of pro-inflammatory cytokines TNF-alpha, IL-6, and IL-1beta was inhibited by PL supplementation. pl 116-118 interleukin 6 Homo sapiens 80-84 11788581-1 2002 Interleukin 6 (IL-6) is endowed with a lectin activity for oligosaccharide ligands possessing the HNK-1 epitope (3-sulfated glucuronic acid) found on some mammalian glycoprotein N-glycans (Cebo, C., Dambrouck, T., Maes, E., Laden, C., Strecker, G., Michalski, J. C., and Zanetta, J. P. (2001) J. Biol. Oligosaccharides 59-74 interleukin 6 Homo sapiens 0-13 26395918-5 2015 Furthermore, fucosterol attenuated CoCl2 induced excess expression of IL-6, IL-1beta and TNF-alpha in HaCaT cells. fucosterol 13-23 interleukin 6 Homo sapiens 70-74 11788581-1 2002 Interleukin 6 (IL-6) is endowed with a lectin activity for oligosaccharide ligands possessing the HNK-1 epitope (3-sulfated glucuronic acid) found on some mammalian glycoprotein N-glycans (Cebo, C., Dambrouck, T., Maes, E., Laden, C., Strecker, G., Michalski, J. C., and Zanetta, J. P. (2001) J. Biol. Oligosaccharides 59-74 interleukin 6 Homo sapiens 15-19 11788581-1 2002 Interleukin 6 (IL-6) is endowed with a lectin activity for oligosaccharide ligands possessing the HNK-1 epitope (3-sulfated glucuronic acid) found on some mammalian glycoprotein N-glycans (Cebo, C., Dambrouck, T., Maes, E., Laden, C., Strecker, G., Michalski, J. C., and Zanetta, J. P. (2001) J. Biol. Glucuronic Acid 124-139 interleukin 6 Homo sapiens 0-13 11788581-1 2002 Interleukin 6 (IL-6) is endowed with a lectin activity for oligosaccharide ligands possessing the HNK-1 epitope (3-sulfated glucuronic acid) found on some mammalian glycoprotein N-glycans (Cebo, C., Dambrouck, T., Maes, E., Laden, C., Strecker, G., Michalski, J. C., and Zanetta, J. P. (2001) J. Biol. Glucuronic Acid 124-139 interleukin 6 Homo sapiens 15-19 26169021-6 2015 RESULTS: We found that the IL-6 -174C/G polymorphism might be associated with decreased risk of TB (C vs. G: OR=0.77, 95% CI=0.64-0.91; CG vs. GG: OR=0.72, 95% CI=0.57-0.90; CC+CG vs. GG: OR=0.71, 95% CI=0.57-0.88). cysteinylglycine 136-138 interleukin 6 Homo sapiens 27-31 29296780-11 2017 In vitro, exogenous IL-6 reduced mitoxantrone-induced apoptosis in cell lines and primary pediatric AML samples. Mitoxantrone 33-45 interleukin 6 Homo sapiens 20-24 11788581-4 2002 Using high affinity oligosaccharide ligands, it is demonstrated that this lectin activity is responsible for the early dephosphorylation of tyrosine residues found on specific proteins induced by interleukin 6 in human resting lymphocytes. Oligosaccharides 20-35 interleukin 6 Homo sapiens 196-209 26169021-6 2015 RESULTS: We found that the IL-6 -174C/G polymorphism might be associated with decreased risk of TB (C vs. G: OR=0.77, 95% CI=0.64-0.91; CG vs. GG: OR=0.72, 95% CI=0.57-0.90; CC+CG vs. GG: OR=0.71, 95% CI=0.57-0.88). cysteinylglycine 177-179 interleukin 6 Homo sapiens 27-31 26169021-8 2015 Moreover, the IL-6 -174 C/G polymorphism was also associated with decreased risk of TB in Asians (C vs. G: OR=0.71, 95% CI=0.54-0.93; CG vs. GG: OR=0.61, 95% CI=0.44-0.85; CC+CG vs. GG: OR=0.63, 95% CI=0.46-0.86). cysteinylglycine 134-136 interleukin 6 Homo sapiens 14-18 11835156-7 2002 DMAEMA (1.6- 6.4 mM) virtually eliminated the acute IL-6 response of these cells to an interleukin-1beta challenge; only at 0.32 mM DMAEMA was the response restored. 2-(dimethylamino)ethyl methacrylate 0-6 interleukin 6 Homo sapiens 52-56 26169021-8 2015 Moreover, the IL-6 -174 C/G polymorphism was also associated with decreased risk of TB in Asians (C vs. G: OR=0.71, 95% CI=0.54-0.93; CG vs. GG: OR=0.61, 95% CI=0.44-0.85; CC+CG vs. GG: OR=0.63, 95% CI=0.46-0.86). cysteinylglycine 175-177 interleukin 6 Homo sapiens 14-18 28323342-8 2017 Higher baseline hs-CRP and IL-6 levels were associated with worse physical performance and gait speed at 12 months independent of age, zoledronic acid use, and comorbidity ( r = 0.25-0.30; all P < .05). Zoledronic Acid 135-150 interleukin 6 Homo sapiens 27-31 26344560-5 2015 RESULTS: HCQ pretreatment reduced the production of pro-inflammatory (TNF-alpha, IL-6, and IL-12) and anti-inflammatory (IL-10 and IL-1 receptor antagonist) cytokines in LPS-stimulated human microglia. Hydroxychloroquine 9-12 interleukin 6 Homo sapiens 81-85 11957164-8 2002 Etomidate, given to lower cortisol during surgery, was associated with significantly decreased IL-6 and IL-10 responses to surgery compared with the placebo group, whereas methylprednisolone alone, given to healthy nonsurgical volunteers, had no effect on these cytokines. Etomidate 0-9 interleukin 6 Homo sapiens 95-99 26238934-0 2015 Pravastatin inhibits fibrinogen- and FDP-induced inflammatory response via reducing the production of IL-6, TNF-alpha and iNOS in vascular smooth muscle cells. Pravastatin 0-11 interleukin 6 Homo sapiens 102-106 28507278-9 2017 We also found that STAT3 inhibitor AG490 decrease expression of CD44v6 by blocking activation of STAT3, even in the presence of IL-6. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 35-40 interleukin 6 Homo sapiens 128-132 28356331-9 2017 Quiescent human prostate stroma exposed to genotoxic agents (e.g., mitoxantrone) in vivo resulted in significant upregulation (2.7- to 5.7-fold; P <= 0.01) of growth factors and cytokines including IL1beta, MMP3, IL6, and IL8. Mitoxantrone 67-79 interleukin 6 Homo sapiens 216-219 11918718-0 2002 Eicosapentaenoic acid, a n-3 polyunsaturated fatty acid differentially modulates TNF-alpha, IL-1alpha, IL-6 and PGE2 expression in UVB-irradiated human keratinocytes. Eicosapentaenoic Acid 0-21 interleukin 6 Homo sapiens 103-107 28697836-6 2017 RESULTS: Compared with the CC genotypes, the IL-6 C-572G G-positive genotype (CG+GG genotype) was significantly associated with an increased susceptibility to moderate to late SPTB (OR=1.35, 95%CI: 1.01-1.80, P=0.04). cysteinylglycine 78-80 interleukin 6 Homo sapiens 45-49 26134265-4 2015 Pre-treatment of TQ inhibited TNF-alpha-induced interleukin-6 (IL-6) and IL-8 production and ICAM-1, VCAM-1, and cadherin-11 (Cad-11) expression in RA-FLS (p<0.01). thymoquinone 17-19 interleukin 6 Homo sapiens 48-61 26134265-4 2015 Pre-treatment of TQ inhibited TNF-alpha-induced interleukin-6 (IL-6) and IL-8 production and ICAM-1, VCAM-1, and cadherin-11 (Cad-11) expression in RA-FLS (p<0.01). thymoquinone 17-19 interleukin 6 Homo sapiens 63-67 26177495-8 2015 After adjusting for BMI and age, IL-6 was positively correlated with HOMA, and SHBG was negatively correlated with HOMA, triglyceride, and LDL. HOMA 69-73 interleukin 6 Homo sapiens 33-37 28669936-7 2017 RESULTS: A 10 mug/m3 increase of NO2 exposure during infancy was associated with a 13.6% (95% confidence interval (CI): 0.8; 28.1%) increase in interleukin-6 (IL-6) levels, as well as with a 27.8% (95% CI: 4.6, 56.2%) increase in IL-10 levels, the latter limited to children with asthma. Nitrogen Dioxide 33-36 interleukin 6 Homo sapiens 144-157 11995475-7 2002 Multiple regression analysis showed that serum levels of interleukin-6 and hepatocyte growth factor on day 0 after surgery were significantly correlated with the postoperative maximum total bilirubin level (P < 0.0001). Bilirubin 190-199 interleukin 6 Homo sapiens 57-70 28669936-7 2017 RESULTS: A 10 mug/m3 increase of NO2 exposure during infancy was associated with a 13.6% (95% confidence interval (CI): 0.8; 28.1%) increase in interleukin-6 (IL-6) levels, as well as with a 27.8% (95% CI: 4.6, 56.2%) increase in IL-10 levels, the latter limited to children with asthma. Nitrogen Dioxide 33-36 interleukin 6 Homo sapiens 159-163 28366867-8 2017 5muM Cd2+ exposure significantly augmented nuclear Nrf2, GSH and GCLC, GCLM, HMOX1, TNFalpha and IL-6 mRNA expression but not GSR, however these upsurges were significantly abrogated by ALA or 1muM Cd2+ pre-treatments. Thioctic Acid 186-189 interleukin 6 Homo sapiens 97-101 25987541-10 2015 IL-1beta-increased IL-6 release was reduced with cytochalasin B, epalrestat, L-NAME or MitoTEMPO treatment (-45%, -62%, -38% and -40%, respectively). MitoTEMPO 87-96 interleukin 6 Homo sapiens 19-23 11995475-8 2002 The maximum interleukin-6 level but not hepatocyte growth factor significantly correlated with the postoperative maximum bilirubin level (P < 0.02). Bilirubin 121-130 interleukin 6 Homo sapiens 12-25 26346655-8 2015 Class B CpG ODNs loaded on the BNNS-PEI complexes enhanced the production of interleukin-6 and tumor necrosis factor-alpha from peripheral blood mononuclear cells compared with CpG ODNs directly loaded on BNNS. bnns 31-35 interleukin 6 Homo sapiens 77-122 11816044-3 2002 This method was combined with H/D off-exchange to identify IL-6 and anti-human IL-6 mouse monoclonal antibody MH166 (150-kDa) binding sites in the IL-6 molecule. mh166 110-115 interleukin 6 Homo sapiens 79-83 26166037-0 2015 Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells. Homoharringtonine 0-17 interleukin 6 Homo sapiens 59-63 27299582-4 2017 RESULTS: In adipocytes from non-obese subjects, palmitic and linoleic acids increased TNF-alpha and IL-6 mRNA expression (p < 0.05), and decreased IL-10 and adiponectin expression (p < 0.05). Linoleic Acids 61-75 interleukin 6 Homo sapiens 100-104 11816044-3 2002 This method was combined with H/D off-exchange to identify IL-6 and anti-human IL-6 mouse monoclonal antibody MH166 (150-kDa) binding sites in the IL-6 molecule. mh166 110-115 interleukin 6 Homo sapiens 79-83 11816044-6 2002 IL-6 was dissociated by using IRMPD, and the interface of IL-6 bound to anti-IL-6 antibody MH166 was determined to analyze the deuterium incorporation level of each fragment ion. mh166 91-96 interleukin 6 Homo sapiens 58-62 26166660-0 2015 Apigenin inhibits indoxyl sulfate-induced endoplasmic reticulum stress and anti-proliferative pathways, CHOP and IL-6/p21, in human renal proximal tubular cells. Indican 18-33 interleukin 6 Homo sapiens 113-117 28214551-3 2017 The BAK effect at 10-4% or 5.10-3% on the gene expressions of interleukin-6 (IL-6), interleukin-8 (IL-8) and matrix metalloproteinase (MMP-9) was investigated using qRT-PCR in 2D and 3D p-hTMC cultures. Benzalkonium Compounds 4-7 interleukin 6 Homo sapiens 62-75 11816044-6 2002 IL-6 was dissociated by using IRMPD, and the interface of IL-6 bound to anti-IL-6 antibody MH166 was determined to analyze the deuterium incorporation level of each fragment ion. mh166 91-96 interleukin 6 Homo sapiens 58-62 28214551-3 2017 The BAK effect at 10-4% or 5.10-3% on the gene expressions of interleukin-6 (IL-6), interleukin-8 (IL-8) and matrix metalloproteinase (MMP-9) was investigated using qRT-PCR in 2D and 3D p-hTMC cultures. Benzalkonium Compounds 4-7 interleukin 6 Homo sapiens 77-81 26166660-1 2015 OBJECTIVE: Indoxyl sulfate (IS) has been reported to induce endoplasmic reticulum (ER) stress in tubular cells and to inhibit the cell proliferation via ER stress and ERK/IL-6/p21 pathways. Indican 11-26 interleukin 6 Homo sapiens 171-175 26166660-1 2015 OBJECTIVE: Indoxyl sulfate (IS) has been reported to induce endoplasmic reticulum (ER) stress in tubular cells and to inhibit the cell proliferation via ER stress and ERK/IL-6/p21 pathways. Indican 28-30 interleukin 6 Homo sapiens 171-175 28214551-5 2017 IL-6 and IL-8 gene expressions increased in presence of BAK in 2D and in 3D p-hTMC cultures. Benzalkonium Compounds 56-59 interleukin 6 Homo sapiens 0-4 11844003-11 2001 CRP and IL-6 were important confounders in the relationship between serum uric acid and overall mortality. Uric Acid 74-83 interleukin 6 Homo sapiens 8-12 28430601-4 2017 We reported the discovery of EVISTA (Raloxifene HCl) as novel inhibitor of IL-6/GP130 protein-protein interactions (PPIs) using multiple ligand simultaneous docking (MLSD) and drug repositioning. Raloxifene Hydrochloride 37-51 interleukin 6 Homo sapiens 75-79 28430601-6 2017 RESULTS: Raloxifene inhibited the P-STAT3 stimulated by IL-6, but not the induction of STAT1 and STAT6 phosphorylation by IFN-gamma, IFN-alpha, and IL-4. Raloxifene Hydrochloride 9-19 interleukin 6 Homo sapiens 56-60 28430601-12 2017 CONCLUSIONS: Our results suggest that Raloxifene is a potent IL-6/GP130 inhibitor and may be a chemoprevention agent for liver cancer by targeting persistent STAT3 signaling. Raloxifene Hydrochloride 38-48 interleukin 6 Homo sapiens 61-65 26020773-7 2015 The production of IL-6, IL-8 and MMP-3 by chondrocytes significantly decreased in chitosan-alginate beads compared to alginate beads. Alginates 91-99 interleukin 6 Homo sapiens 18-22 25961745-8 2015 3-MA, NAC and DPI inhibited HG-induced interleukin-6 production in BMSCs. diphenyleneiodonium 14-17 interleukin 6 Homo sapiens 39-52 11783697-1 2001 To determine whether ceftazidime and imipenem, which target two different penicillin-binding proteins, result in different amounts of endotoxin and cytokine release in patients with gram-negative infection, plasma endotoxin, interleukin-6, and tumor necrosis factor alpha were measured during the first 24 h of antibiotic therapy in 27 patients with gram-negative infection who had been randomized to receive either ceftazidime 2 g t.i.d. Imipenem 37-45 interleukin 6 Homo sapiens 225-238 25984437-2 2015 In the previous study, we reported that protective effect of proline involves the early activation of IL-6/STAT-3 pathway, an anti-inflammatory and regenerative signaling in the liver. Proline 61-68 interleukin 6 Homo sapiens 102-106 28396316-7 2017 Neutralization studies identified IL-6 and CXCL8 as factors secreted by EVTs that induce endothelial cell CCL14 and CXCL6 expression. evts 72-76 interleukin 6 Homo sapiens 34-38 11683039-4 2001 Moreover, HaCaT keratinocytes were incubated with mizolastine under various UV treatment modalities in vitro to study its effect on the release of inflammatory cytokines, i.e. interleukin (IL)-1 alpha, IL-6 and tumor necrosis factor alpha (TNF-alpha). mizolastine 50-61 interleukin 6 Homo sapiens 202-206 28481326-0 2017 The Dose-Response Association between Nitrogen Dioxide Exposure and Serum Interleukin-6 Concentrations. Nitrogen Dioxide 38-54 interleukin 6 Homo sapiens 74-87 28481326-6 2017 We found a positive association with increasing serum IL-6 concentration (geometric mean 1.20 (95% CI: 1.1 to 1.3, p = 0.001) per quartile increase in NO2). Nitrogen Dioxide 151-154 interleukin 6 Homo sapiens 54-58 28481326-8 2017 However, there was some evidence consistent with serum IL-6 being on the causal pathway between NO2 and cardiovascular risk. Nitrogen Dioxide 96-99 interleukin 6 Homo sapiens 55-59 28391993-6 2017 Similarly, the LPS-induced expression of IL-6, which is regulated by IkappaBzeta, was suppressed by NaN3. Sodium Azide 100-104 interleukin 6 Homo sapiens 41-45 25608533-9 2015 EPS-stimulated mRNA expression levels of MYH7, IL-6, and IL-8 correlated negatively with subjects" HbA1c and/or fasting plasma glucose, suggesting an effect linked to the diabetic phenotype. eps 0-3 interleukin 6 Homo sapiens 47-51 25715786-8 2015 In the TEA group, there was significant but transient reduced level of serum epinephrine and a higher level of insulin at 3 and 6 h. In the WIC, there was a significant reduction of interleukin-6 values, especially at 12 h. There was no significant difference observed in the other endpoints. tea 7-10 interleukin 6 Homo sapiens 182-195 11683039-7 2001 An inhibitory effect in vitro of 10 nM mizolastine upon UV-induced cytokine release from HaCaT keratinocytes was observed for IL-1 alpha at 24 h after 10 J/cm2 UVA1, for IL-6 at 48 h after 10 J/cm2 UVA1 and 30 mJ/cm2 UVB, and also for TNF-alpha at 4 h after 10 J/cm2 UVA, 10 J/cm2 UVA1 and 30 mJ/cm2 UVB, respectively. mizolastine 39-50 interleukin 6 Homo sapiens 170-174 25457208-8 2015 Moreover, ethanol (100 mM) and acetaldehyde (100 and 500 muM) increased levels of IL-6 and IFN-gamma, and suppressed autophagy in VA-13 cells, effects which were markedly alleviated by rapamycin. Acetaldehyde 31-43 interleukin 6 Homo sapiens 82-86 27639185-5 2017 VPA and lithium both induce significant down-regulation of group I CD1 expression and secretion of IL-6 during differentiation of human monocyte-derived immature DC, while they differ in the induction of CD83 and CD86 expression, secretion of IL-8, IL-10, and TNF-alpha. Valproic Acid 0-3 interleukin 6 Homo sapiens 99-103 11718104-1 2001 Addition of human recombinant interleukin 6 (IL-6) to culture medium (supplemented MEM without or with 10% fetal calf serum (FCS)) of human skin fibroblasts exerted a stimulating effect in a dose-dependent manner on glycosaminoglycan (GAG) synthesis, including hyaluronic acid (hyaluronan) synthesis, of young (phase-II) skin fibroblasts in concentrations of 1 ng/ml and 10 ng/ml. Glycosaminoglycans 216-233 interleukin 6 Homo sapiens 30-43 28377715-6 2017 Mechanistically, dioscin significantly decreased the protein levels of TLR4, MyD88, TRAF6, TKB1, TRAF3, phosphorylation levels of PI3K, Akt, IkappaBalpha, NF-kappaB, and the mRNA levels of IL-1beta, IL-6, and TNF-alpha against oxidative stress and inflammation (p < 0.05). dioscin 17-24 interleukin 6 Homo sapiens 199-203 25898559-8 2015 RESULTS: DP-M&O decreased the levels of TNF-alpha, IL-1beta, IL-6, and IL-8 and increased that of IL-10 in a concentration-dependent manner. 3-(3,5-dichlorophenyl)-1-methyl-2,5-pyrrolidinedione 9-13 interleukin 6 Homo sapiens 65-69 25973048-14 2015 After the expression of S100A12 in propylene glycol monomethyl ether acetate (PMA) induced human macrophages was silenced, the expression of proinflammatory factor IL-1, IL-6 and TNF-alpha was down-regulated. 2-methoxypropyl-1-acetate 35-76 interleukin 6 Homo sapiens 170-174 25973048-14 2015 After the expression of S100A12 in propylene glycol monomethyl ether acetate (PMA) induced human macrophages was silenced, the expression of proinflammatory factor IL-1, IL-6 and TNF-alpha was down-regulated. 2-methoxypropyl-1-acetate 78-81 interleukin 6 Homo sapiens 170-174 11718104-1 2001 Addition of human recombinant interleukin 6 (IL-6) to culture medium (supplemented MEM without or with 10% fetal calf serum (FCS)) of human skin fibroblasts exerted a stimulating effect in a dose-dependent manner on glycosaminoglycan (GAG) synthesis, including hyaluronic acid (hyaluronan) synthesis, of young (phase-II) skin fibroblasts in concentrations of 1 ng/ml and 10 ng/ml. Glycosaminoglycans 216-233 interleukin 6 Homo sapiens 45-49 26273599-5 2015 Markedly decreased levels of IL-17, retinoid-related orphan receptor C (RORc), and MMP-3 mRNA expression were also observed in IL-6-induced RASFs in the presence of T-614 or MTX compared with those in its absence. T 614 165-170 interleukin 6 Homo sapiens 127-131 11718104-1 2001 Addition of human recombinant interleukin 6 (IL-6) to culture medium (supplemented MEM without or with 10% fetal calf serum (FCS)) of human skin fibroblasts exerted a stimulating effect in a dose-dependent manner on glycosaminoglycan (GAG) synthesis, including hyaluronic acid (hyaluronan) synthesis, of young (phase-II) skin fibroblasts in concentrations of 1 ng/ml and 10 ng/ml. Glycosaminoglycans 235-238 interleukin 6 Homo sapiens 30-43 28057547-6 2017 We have previously shown that a series of 4-alkoxy-6,9-dichloro[1,2,4]triazolo[4,3-a]quinoxalines exhibit potent anti-inflammatory activity, inhibiting the production of TNF-alpha and IL-6. 4-alkoxy-6,9-dichloro[1,2,4]triazolo[4,3-a]quinoxalines 42-97 interleukin 6 Homo sapiens 184-188 11718104-1 2001 Addition of human recombinant interleukin 6 (IL-6) to culture medium (supplemented MEM without or with 10% fetal calf serum (FCS)) of human skin fibroblasts exerted a stimulating effect in a dose-dependent manner on glycosaminoglycan (GAG) synthesis, including hyaluronic acid (hyaluronan) synthesis, of young (phase-II) skin fibroblasts in concentrations of 1 ng/ml and 10 ng/ml. Glycosaminoglycans 235-238 interleukin 6 Homo sapiens 45-49 11718104-1 2001 Addition of human recombinant interleukin 6 (IL-6) to culture medium (supplemented MEM without or with 10% fetal calf serum (FCS)) of human skin fibroblasts exerted a stimulating effect in a dose-dependent manner on glycosaminoglycan (GAG) synthesis, including hyaluronic acid (hyaluronan) synthesis, of young (phase-II) skin fibroblasts in concentrations of 1 ng/ml and 10 ng/ml. Hyaluronic Acid 261-276 interleukin 6 Homo sapiens 30-43 26664829-12 2015 IL6 G-174C GG genotype (2.23 +- 0.14 pg/mL) was 19% greater than CG or CC genotypes. cysteinylglycine 65-67 interleukin 6 Homo sapiens 0-3 11718104-1 2001 Addition of human recombinant interleukin 6 (IL-6) to culture medium (supplemented MEM without or with 10% fetal calf serum (FCS)) of human skin fibroblasts exerted a stimulating effect in a dose-dependent manner on glycosaminoglycan (GAG) synthesis, including hyaluronic acid (hyaluronan) synthesis, of young (phase-II) skin fibroblasts in concentrations of 1 ng/ml and 10 ng/ml. Hyaluronic Acid 261-276 interleukin 6 Homo sapiens 45-49 11718104-1 2001 Addition of human recombinant interleukin 6 (IL-6) to culture medium (supplemented MEM without or with 10% fetal calf serum (FCS)) of human skin fibroblasts exerted a stimulating effect in a dose-dependent manner on glycosaminoglycan (GAG) synthesis, including hyaluronic acid (hyaluronan) synthesis, of young (phase-II) skin fibroblasts in concentrations of 1 ng/ml and 10 ng/ml. Hyaluronic Acid 278-288 interleukin 6 Homo sapiens 30-43 28063793-8 2017 Inhibition of JAK/STAT with AG490 (10muM) or piceatannol (50muM) blocked (P<0.01 10ng/mL IL-6vs. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 28-33 interleukin 6 Homo sapiens 92-96 11718104-1 2001 Addition of human recombinant interleukin 6 (IL-6) to culture medium (supplemented MEM without or with 10% fetal calf serum (FCS)) of human skin fibroblasts exerted a stimulating effect in a dose-dependent manner on glycosaminoglycan (GAG) synthesis, including hyaluronic acid (hyaluronan) synthesis, of young (phase-II) skin fibroblasts in concentrations of 1 ng/ml and 10 ng/ml. Hyaluronic Acid 278-288 interleukin 6 Homo sapiens 45-49 11718104-3 2001 Stimulation with 1 ng/ml and 10 ng/ml IL-6 led to an increase in hyaluronic acid from 48% to 61% (-FCS) and from 77% to 90% (+10% FCS), respectively. Hyaluronic Acid 65-80 interleukin 6 Homo sapiens 38-42 27186953-5 2017 Unexpectedly, NaW further induced IL-6, IL-8, and MCP-1 secretion in both N- and D-RPTEC, together with lower levels of IL-1 RA, IL-4, IL-10, and GM-CSF, suggesting that it may contribute to the extent of renal damage/repair during DKD. naw 14-17 interleukin 6 Homo sapiens 34-38 28064076-7 2017 Drospirenone significantly decreased IL-6, IL-8, VEGF and NGF mRNA expression by ESC. drospirenone 0-12 interleukin 6 Homo sapiens 37-41 26294848-7 2015 Hi-oxLDL induced mannose receptor expression and production of IL-6 and monocyte chemoattractant protein-1, which mostly match the phenotype of M2 macrophages. hi-oxldl 0-8 interleukin 6 Homo sapiens 63-67 25670984-10 2014 The production of IL-6 by LPS-activated moDC was also reduced significantly when eicosapentaenic acid was added as a RAMEA complex as compared to its DMSO-solubilized form or to the other two n-3 fatty acids either complexed or not. Dimethyl Sulfoxide 150-154 interleukin 6 Homo sapiens 18-22 28064076-8 2017 Drospirenone (10-5M) significantly decreased IL-6 secretion and 10-7M drospirenone decreased IL-8 and VEGF secretion. drospirenone 0-12 interleukin 6 Homo sapiens 45-49 11494336-9 2001 Neutralization of IL-6 with neutralizing antibody abrogated DU-145 conditioned media induced promatrilysin expression to baseline levels. du-145 60-66 interleukin 6 Homo sapiens 18-22 29230423-7 2017 The serum IL-6 and IL-10 concentrations were significantly higher among the AR-naive participants compared to the ART-experienced group. Argon 76-78 interleukin 6 Homo sapiens 10-14 27941330-6 2017 BAK alone only increased IL-6 expression. Benzalkonium Compounds 0-3 interleukin 6 Homo sapiens 25-29 28947926-7 2017 The treatment of oleate or MitoTEMPO to palmitate-conditioned myotubes led to inhibition of palmitate-induced mRNA expression of proinflammatory (TNF-alpha and IL6), mitochondrial fission (Drp1 and Fis1), and atrophy markers (myostatin and atrogin1). MitoTEMPO 27-36 interleukin 6 Homo sapiens 160-163 27390295-4 2016 We used dermal fibroblasts from SSc patients and control subjects to evaluate LPA-induced expression of IL-6, and IL-6-induced expression of ATX. lysophosphatidic acid 78-81 interleukin 6 Homo sapiens 104-108 27390295-10 2016 Expression of both ATX and IL-6 was increased in SSc skin, and LPA-induced IL-6 levels and IL-6-induced ATX levels were increased in fibroblasts from SSc patients compared with controls. lysophosphatidic acid 63-66 interleukin 6 Homo sapiens 75-79 27576059-4 2016 Results suggest that treatment with daidzein, raloxifene and E2 increased the levels of OPG and decreased those of RANKL and IL-6. Raloxifene Hydrochloride 46-56 interleukin 6 Homo sapiens 125-129 27267669-5 2016 Nintedanib, a FGF- and PDGF-receptor targeting drug, more efficiently blocked bFGF + PDGF-BB-induced IL-6 and hyaluronan production than dasatinib that only targets PDGF-receptor. nintedanib 0-10 interleukin 6 Homo sapiens 101-105 27491751-0 2016 Poligalen, a new coumarin from Polygala boliviensis, reduces the release of TNF and IL-6 independent of NF-kB downregulation. poligalen 0-9 interleukin 6 Homo sapiens 84-88 27491751-3 2016 Poligalen exhibits immunomodulatory effects, reducing the levels of IL-6 and TNF after LPS stimulation in peritoneal macrophages. poligalen 0-9 interleukin 6 Homo sapiens 68-72 28978005-0 2017 Bazedoxifene enhances the anti-tumor effects of cisplatin and radiation treatment by blocking IL-6 signaling in head and neck cancer. bazedoxifene 0-12 interleukin 6 Homo sapiens 94-98 28978005-5 2017 Our results suggest that BZA inhibits IL-6 signaling by disrupting IL-6R/gp130 protein-protein interactions. bazedoxifene 25-28 interleukin 6 Homo sapiens 38-42 28978005-11 2017 Taken together, our results suggest that targeting IL-6 signaling with bazedoxifene could be an effective treatment strategy for the treatment of HNSCC patients. bazedoxifene 71-83 interleukin 6 Homo sapiens 51-55 27018002-0 2016 9- and 13-Hydroxy-octadecadienoic acids (9+13 HODE) are inversely related to granulocyte colony stimulating factor and IL-6 in runners after 2h running. 9- and 13-hydroxy-octadecadienoic acids 0-39 interleukin 6 Homo sapiens 119-123 27470424-5 2016 The expression levels of c-Fos, nuclear factor kappaB (NFkappaB), interleukin (IL)-6, and tumor necrosis factor (TNF)-alpha were upregulated in myopic eyes and downregulated upon treatment with atropine. Atropine 194-202 interleukin 6 Homo sapiens 66-84 27086282-2 2016 Moreover, lipoic acid treatment for 3 h increased and promoted heat shock-induced interleukin (IL)-6 mRNA and protein levels and that for 24 h downregulated IL-6 mRNA expression, suggesting a dual effect of lipoic acid on IL-6 regulation. Thioctic Acid 10-21 interleukin 6 Homo sapiens 222-226 27086282-2 2016 Moreover, lipoic acid treatment for 3 h increased and promoted heat shock-induced interleukin (IL)-6 mRNA and protein levels and that for 24 h downregulated IL-6 mRNA expression, suggesting a dual effect of lipoic acid on IL-6 regulation. Thioctic Acid 207-218 interleukin 6 Homo sapiens 222-226 27145239-10 2016 LCFA (oleic acid) up-regulated tumor necrosis fator-alpha, monocyte chemoattractant-1 and interleukin-1beta while down-regulated IL-6 and IL-8 secretion to a higher extent than MCFA in mRNA and protein levels. Oleic Acid 6-16 interleukin 6 Homo sapiens 129-133 27018372-0 2016 Evaluation of interleukin-6 and serotonin as biomarkers to predict response to fluoxetine. Fluoxetine 79-89 interleukin 6 Homo sapiens 14-27 26820672-10 2016 In addition, the groups treated with SSP and beta-carotene showed significantly reduced levels of tumor necrosis factor-alpha and interleukin-6 compared with the control group. beta Carotene 45-58 interleukin 6 Homo sapiens 130-143 26432597-3 2016 Based on microarray, TNF and IL6 were among the most highly upregulated genes in both stimulated conditions, each of which was significantly inhibited by preincubation with hydroxychloroquine (HCQ). Hydroxychloroquine 173-191 interleukin 6 Homo sapiens 29-32 26432597-3 2016 Based on microarray, TNF and IL6 were among the most highly upregulated genes in both stimulated conditions, each of which was significantly inhibited by preincubation with hydroxychloroquine (HCQ). Hydroxychloroquine 193-196 interleukin 6 Homo sapiens 29-32 25976322-7 2016 CTQ+ patients also exhibited increased baseline expression of gene transcripts related to inflammatory signaling, and baseline inflammatory markers including c-reactive protein, interleukin (IL)-6, and IL-1 receptor antagonist were positively correlated with depression, fatigue, and stress scores in CTQ+ but not CTQ- patients. cysteine tryptophylquinone 0-3 interleukin 6 Homo sapiens 178-196 26899608-4 2016 Serum interleukin-6 (IL-6) levels were significantly lower in the bilateral-DEX group than in the uni-saline group 6 and 24h postoperatively, and were negatively correlated with total DEX dosage 24h postoperatively. uni-saline 98-108 interleukin 6 Homo sapiens 6-19 26899608-4 2016 Serum interleukin-6 (IL-6) levels were significantly lower in the bilateral-DEX group than in the uni-saline group 6 and 24h postoperatively, and were negatively correlated with total DEX dosage 24h postoperatively. uni-saline 98-108 interleukin 6 Homo sapiens 21-25 27349023-10 2016 In SCF patients, the average serum IL-6 levels (pg/mL) in CG + GG genotype (4.78 +- 0.42) were statistically higher than in CC genotype (3.93 +- 0.36) (p = 0.0000). cysteinylglycine 58-60 interleukin 6 Homo sapiens 35-39 26765462-2 2016 Alpha-lipoic acid (ALA) is well known as a multifunctional antioxidant, helping to protect cells against oxidative stress and inflammatory damage.The aim of this study was to investigate the effects of ALA on intracellular production of reactive oxygen species (ROS), inflammation, and adipogenesis using primary cultured orbital fibroblasts from patients with GO.Intracellular ROS levels and mRNA expressions of proinflammatory cytokines and chemokines including intercellular adhesion molecule-1 (ICAM-1), interleukin (IL)-6, monocyte chemoattractant protein (MCP)-1, and regulated upon activation normal T cell expressed and presumably secreted (RANTES) were measured. Thioctic Acid 0-17 interleukin 6 Homo sapiens 508-526 26765462-2 2016 Alpha-lipoic acid (ALA) is well known as a multifunctional antioxidant, helping to protect cells against oxidative stress and inflammatory damage.The aim of this study was to investigate the effects of ALA on intracellular production of reactive oxygen species (ROS), inflammation, and adipogenesis using primary cultured orbital fibroblasts from patients with GO.Intracellular ROS levels and mRNA expressions of proinflammatory cytokines and chemokines including intercellular adhesion molecule-1 (ICAM-1), interleukin (IL)-6, monocyte chemoattractant protein (MCP)-1, and regulated upon activation normal T cell expressed and presumably secreted (RANTES) were measured. Thioctic Acid 19-22 interleukin 6 Homo sapiens 508-526 26765462-6 2016 Tumor necrosis factor (TNF)alpha-induced mRNA expressions of ICAM-1, IL-6, MCP-1, and RANTES were inhibited by ALA treatment. Thioctic Acid 111-114 interleukin 6 Homo sapiens 69-73 27034587-5 2016 Moreover, TNF-alpha-induced IL-6 was partly but significantly blunted by pravastatin detected by ELISA. Pravastatin 73-84 interleukin 6 Homo sapiens 28-32 27034587-9 2016 Together, these data suggested that pravastatin could suppress IL-6 production via promoting klotho expression in endothelial cells under inflammatory stimuli. Pravastatin 36-47 interleukin 6 Homo sapiens 63-67 26439246-9 2016 Pre-treatment of raloxifene (8 mg/kg) caused marked decrease in serum creatinine, blood urea nitrogen, TNF-alpha and IL-6 levels whereas increase in albumin and IL-10 levels. Raloxifene Hydrochloride 17-27 interleukin 6 Homo sapiens 117-121 26394632-2 2015 iMCD is caused by dysregulated production of IL-6 in the lymph nodes, and is associated with high morbidity, and potentially fatal consequences. imcd 0-4 interleukin 6 Homo sapiens 45-49 26884958-9 2015 Multivariate analysis showed that D/P Cr was independently correlated with IL-6 and negatively correlated with serum albumin (r=-0.369, P=0.045). Chromium 38-40 interleukin 6 Homo sapiens 75-79 26202921-10 2015 MAIN RESULTS AND THE ROLE OF CHANCE: The long chain saturated fatty acids, stearic and palmitic (PA), stimulated the synthesis as well as the release of TNF-alpha, IL-6 and IL-8 by trophoblast cells (2- to 6-fold, P < 0.001). long chain saturated fatty acids 41-73 interleukin 6 Homo sapiens 164-168 26202921-10 2015 MAIN RESULTS AND THE ROLE OF CHANCE: The long chain saturated fatty acids, stearic and palmitic (PA), stimulated the synthesis as well as the release of TNF-alpha, IL-6 and IL-8 by trophoblast cells (2- to 6-fold, P < 0.001). Protactinium 97-99 interleukin 6 Homo sapiens 164-168 25529330-0 2015 Arecoline increases basic fibroblast growth factor but reduces expression of IL-1, IL-6, G-CSF and GM-CSF in human umbilical vein endothelium. Arecoline 0-9 interleukin 6 Homo sapiens 83-87 25753493-2 2015 OBJECTIVE: To assess the effect of alpha-lipoic acid (ALA) supplementation on IL-6, hs-CRP, FBS, anthropometric indices, food intake and blood pressure in male patients with chronic spinal cord injury (SCI). Thioctic Acid 54-57 interleukin 6 Homo sapiens 78-82 25751232-9 2015 Patients in the carbon dioxide group had lower concentrations of serum and BALF interleukin (IL)-1, IL-6, and IL-8, but higher serum concentrations of IL-10, accompanied by reduced numbers of cells and neutrophils as well as lower concentrations of protein in the BALF. Carbon Dioxide 16-30 interleukin 6 Homo sapiens 100-104 26125767-9 2015 We found a positive correlation between IL-6, TNF-alpha, YKL-40, and CRP levels 48 h after CBP treatment. 4,4'-Bis(N-carbazolyl)-1,1'-biphenyl 91-94 interleukin 6 Homo sapiens 40-44 25780881-8 2015 We found a significant reduction in IL-6 mRNA expression ratio of TP(3) to TP(1) following AA application among BDDs. bdds 112-116 interleukin 6 Homo sapiens 36-40 25132247-8 2014 In addition, the Dex group had lower serum CK-MB, IL-6, cTnI and GP-BB concentrations than the control group (P < 0.05). Dextromethorphan 17-20 interleukin 6 Homo sapiens 50-54 25255717-10 2014 ASMC treated with FCCM were immunopositive for IL-8/IL-6 and produced more IL-8/IL-6. fccm 18-22 interleukin 6 Homo sapiens 52-56 25255717-10 2014 ASMC treated with FCCM were immunopositive for IL-8/IL-6 and produced more IL-8/IL-6. fccm 18-22 interleukin 6 Homo sapiens 80-84 25138157-5 2014 Enzyme-linked immunosorbent assay (ELISA) revealed that EC-TC contact has a synergistic effect on the expression of the cytokines interleukin (IL)-8, IL-6, and growth-related oncogene alpha (Gro-alpha). ec-tc 56-61 interleukin 6 Homo sapiens 150-154 24590680-12 2014 Serum IL-6 significantly decreased in bLf-treated women and increased in ferrous sulphate-treated women. ferrous sulfate 73-89 interleukin 6 Homo sapiens 6-10 25046000-5 2014 When delivered in combination with doxorubicin, one of the drugs, vincristine, was also capable of synergistically activating the NLRP3-dependent inflammasome and increasing expression of IL-1beta, IL-6, and CXCL1. Vincristine 66-77 interleukin 6 Homo sapiens 198-202 25046000-7 2014 Three small-molecule inhibitors known to suppress activity of kinases situated upstream of mitogen-activated kinases (MAPKs) inhibited the expression of IL-1beta, IL-6, and CXCL1 when doxorubicin and vincristine were used singly or together, so specific kinase inhibitors may be useful in reducing inflammation in patients receiving chemotherapy. Vincristine 200-211 interleukin 6 Homo sapiens 163-167 25035139-4 2014 In the present study, we found that fluoxetine significantly inhibited lipopolysaccharide (LPS)-induced production of tumor necrosis factor-alpha (TNF-alpha), interleukin- 6 (IL-6) and nitric oxide (NO) and reduced the phosphorylation of transforming growth factor-beta-activated kinase 1 (TAK1) and nuclear factor-kappa B (NF-kappaB) p65 nuclear translocation in microglia. Fluoxetine 36-46 interleukin 6 Homo sapiens 159-173 25035139-4 2014 In the present study, we found that fluoxetine significantly inhibited lipopolysaccharide (LPS)-induced production of tumor necrosis factor-alpha (TNF-alpha), interleukin- 6 (IL-6) and nitric oxide (NO) and reduced the phosphorylation of transforming growth factor-beta-activated kinase 1 (TAK1) and nuclear factor-kappa B (NF-kappaB) p65 nuclear translocation in microglia. Fluoxetine 36-46 interleukin 6 Homo sapiens 175-179 25131477-7 2014 RESULTS: Paired Wilcoxon tests showed that the IL-6, IL-10, and IL-6/IL-10 were significantly higher in ox-LDL medium than in PBS one (all P < 0.01). ox-ldl medium 104-117 interleukin 6 Homo sapiens 47-51 25131477-7 2014 RESULTS: Paired Wilcoxon tests showed that the IL-6, IL-10, and IL-6/IL-10 were significantly higher in ox-LDL medium than in PBS one (all P < 0.01). ox-ldl medium 104-117 interleukin 6 Homo sapiens 64-68 25010330-7 2014 Among patients with ANS dysregulation or PE, the expression frequency of CD4+Foxp3+ increased markedly after milrinone treatment, and was associated with reduction of plasma levels IL-6, IL-8 and IL-10. Milrinone 109-118 interleukin 6 Homo sapiens 181-185 24982360-3 2014 Interleukin-6 polymorphism was detected by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) and analyzed in 3% agarose gel. Sepharose 140-147 interleukin 6 Homo sapiens 0-13 24792438-1 2014 Lysophosphatidic acid (LPA) is a pleiotropic lipid mediator that promotes motility, survival, and the synthesis of chemokines/cytokines such as interleukin-8 (IL-8) and interleukin-6 by human fibroblast-like synoviocytes from patients with rheumatoid arthritis (RAFLS). lysophosphatidic acid 0-21 interleukin 6 Homo sapiens 169-182 24792438-1 2014 Lysophosphatidic acid (LPA) is a pleiotropic lipid mediator that promotes motility, survival, and the synthesis of chemokines/cytokines such as interleukin-8 (IL-8) and interleukin-6 by human fibroblast-like synoviocytes from patients with rheumatoid arthritis (RAFLS). lysophosphatidic acid 23-26 interleukin 6 Homo sapiens 169-182 24927761-6 2014 Staining of CD11b showed that adjudin markedly inhibited microglial activation in both the cortex and the striatum, accompanied by a reduction in the expression and release of cytokines TNF-alpha, IL-1beta and IL-6. 1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide 30-37 interleukin 6 Homo sapiens 210-214 24503057-3 2014 OBJECTIVE: Therefore we investigated whether LPS-induced expression of the pro-inflammatory cytokine interleukin-6 (IL-6) influences hypericin and protoporphyrin IX (PpIX) accumulation, and their photocytotoxicity. hypericin 133-142 interleukin 6 Homo sapiens 101-114 24503057-3 2014 OBJECTIVE: Therefore we investigated whether LPS-induced expression of the pro-inflammatory cytokine interleukin-6 (IL-6) influences hypericin and protoporphyrin IX (PpIX) accumulation, and their photocytotoxicity. hypericin 133-142 interleukin 6 Homo sapiens 116-120 24720974-2 2014 A novel competitive electrochemical immunosensor was then proposed by combining the ERGO-AuPdNPs platform with silver nanoparticles (AgNPs) functionalized polystyrene bionanolabel for the sensitive detection of human interleukin-6 (IL-6). Polystyrenes 155-166 interleukin 6 Homo sapiens 217-230 24720974-2 2014 A novel competitive electrochemical immunosensor was then proposed by combining the ERGO-AuPdNPs platform with silver nanoparticles (AgNPs) functionalized polystyrene bionanolabel for the sensitive detection of human interleukin-6 (IL-6). Polystyrenes 155-166 interleukin 6 Homo sapiens 232-236 24182989-8 2014 Pretreatment with TQ also inhibited the LPS-induced proinflammatory response in LX2 cells as demonstrated by reduced mRNA expression of IL-6 and MCP-1. thymoquinone 18-20 interleukin 6 Homo sapiens 136-140 24576840-7 2014 A significant association between the decrease of indoxyl sulfate and changes of sTWEAK and interleukin-6 was noted. Indican 50-65 interleukin 6 Homo sapiens 92-105 24126150-3 2014 Therefore, the objective of this study was to examine the inhibitory effect of an exogenous GC (dexamethasone, DEX) on leptin- and lipopolysaccharide (LPS)-induced IL-6 production by peripheral blood mononuclear cells (PBMCs) ex vivo in obese subjects compared to normal-weight subjects. Dextromethorphan 111-114 interleukin 6 Homo sapiens 164-168 24126150-9 2014 The suppressive effect of DEX on leptin- and LPS-induced IL-6 production (IC50) was not different between the two groups. Dextromethorphan 26-29 interleukin 6 Homo sapiens 57-61 24372204-4 2014 Both, ectoine and lauryl-ectoine considerably decreased lipopolysaccharide (LPS)-induced interleukin (IL)- 1, IL-6, tumor necrosis factor (TNF)- alpha, and cyclooxygenase (COX)-2 gene expression in macrophages as well as TNF-alpha- induced IL-1, IL-6 and COX-2 expression in RISM cells. ectoine 6-13 interleukin 6 Homo sapiens 110-114 24372204-4 2014 Both, ectoine and lauryl-ectoine considerably decreased lipopolysaccharide (LPS)-induced interleukin (IL)- 1, IL-6, tumor necrosis factor (TNF)- alpha, and cyclooxygenase (COX)-2 gene expression in macrophages as well as TNF-alpha- induced IL-1, IL-6 and COX-2 expression in RISM cells. ectoine 6-13 interleukin 6 Homo sapiens 246-250 24671843-9 2014 In these patients, we observed that the switching from Bic-HD to HFR allowed an improvement of inflammatory as testified by a significant decrement of serum levels of CRP IL-6, IL-1 and TNF- and a significant increase of albumin and pre-albumin. imidazole mustard 55-58 interleukin 6 Homo sapiens 171-175 24757498-2 2014 Recent in vitro and animal studies of valproic acid (VPA) report antioxidative and anti-inflammatory properties, and suppression of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha. Valproic Acid 38-51 interleukin 6 Homo sapiens 132-150 24757498-2 2014 Recent in vitro and animal studies of valproic acid (VPA) report antioxidative and anti-inflammatory properties, and suppression of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha. Valproic Acid 53-56 interleukin 6 Homo sapiens 132-150 24149444-7 2013 Intakes of beta-carotene equivalents and vitamin C were associated with adiponectin; saturated fatty acids (SFA), vitamin A, manganese and selenium with leptin; linoleic acid with PAI-1; and oleic acid and vitamin E with IL-6. beta Carotene 11-24 interleukin 6 Homo sapiens 221-225 24238522-4 2013 The expression and half-life of IL-6 mRNA were then determined in cells that had been treated with actinomycin D. Dactinomycin 99-112 interleukin 6 Homo sapiens 32-36 23632235-8 2013 The mean serum IL-6 level remained unchanged in the CLA group but increased remarkably in the placebo group. Linoleic Acids, Conjugated 52-55 interleukin 6 Homo sapiens 15-19 24241092-7 2013 Supplementation of vitamin E with and without ALA significantly reduced interleukin-6 concentration. Thioctic Acid 46-49 interleukin 6 Homo sapiens 72-85 23916117-8 2013 In 12 invasive cancer NAF samples we found a significant positive linear correlation among aluminium, carbonyls and pro-inflammatory IL-6 cytokine (Y = 64.79x-39.63, r(2) 0.8192, p < 0.0005), as well as pro-inflammatory monocyte chemoattractant MCP-1 cytokine (Y = 2026x-866, r(2) 0.9495, p < 0.0001). Aluminum 91-100 interleukin 6 Homo sapiens 133-137 23618972-7 2013 The network analysis implied that Cr(6+) application strongly induced the IL-6-stimulated inflammatory pathway. CR 6 34-40 interleukin 6 Homo sapiens 74-78 23618972-9 2013 Increased IL-6 modulation of the fucosylation of haptoglobin was also identified in Cr(6+)-treated samples. CR 6 84-90 interleukin 6 Homo sapiens 10-14 23791923-7 2013 Furthermore, based on interference with IL-6 secretion, we show potential (chemical) interactions between dexamethasone and sugammadex. Sugammadex 124-134 interleukin 6 Homo sapiens 40-44 23811089-0 2013 First synthesis and biological evaluation of 4-amino-2-aryl-6,9-dichlorobenzo[g]pteridines as inhibitors of TNF-alpha and IL-6. 4-amino-2-aryl-6,9-dichlorobenzo[g]pteridines 45-90 interleukin 6 Homo sapiens 122-126 25677765-10 2015 Furthermore, wogonoside markedly decreased production of IL-1beta, TNF-alpha and IL-6 and suppressed mRNA expression of pro-IL-1beta and NLRP3 in phorbol myristate acetate (PMA)-differentiated monocytic THP-1 cells via inhibiting the activation of NF-kappaB and NLRP3 inflammasome. wogonoside 13-23 interleukin 6 Homo sapiens 81-85 25451977-5 2015 Both in human myometrium and amnion, OT-induced activation of the canonical NF-kappaB pathway upregulated key inflammatory labour-associated genes including IL-8, CCL5, IL-6 and COX-2. Oxytocin 37-39 interleukin 6 Homo sapiens 169-173 25808165-10 2015 However, most of the metals including (V(+4), V(+5)), (Cr(+3), Cr(+6)), Zn, and Pb inhibited the production of both IL-6 and IL-8. Chromium 55-57 interleukin 6 Homo sapiens 116-120 25808165-10 2015 However, most of the metals including (V(+4), V(+5)), (Cr(+3), Cr(+6)), Zn, and Pb inhibited the production of both IL-6 and IL-8. Chromium 63-65 interleukin 6 Homo sapiens 116-120 25808165-10 2015 However, most of the metals including (V(+4), V(+5)), (Cr(+3), Cr(+6)), Zn, and Pb inhibited the production of both IL-6 and IL-8. Lead 80-82 interleukin 6 Homo sapiens 116-120 24069553-4 2013 in Cancer Cell demonstrate that sphingosine kinase 1 (SphK1)-mediated upregulation of sphingosine-1-phosphate (S1P) drives a persistent NFkappaB/IL-6/STAT3/sphingosine-1-phosphate receptor 1 (S1PR1) amplification loop that is critical to the development of chronic colitis and colitis-associated cancer. sphingosine 1-phosphate 86-109 interleukin 6 Homo sapiens 145-149 24069553-5 2013 FTY720, an antagonist of S1PR1, abolished persistent NFkappaB/IL-6/STAT3 signaling and reduced the development and progression of colitis-associated cancer. Fingolimod Hydrochloride 0-6 interleukin 6 Homo sapiens 62-66 11449408-6 2001 The percentage of IL-6 and TNF-alpha-producing monocytes after 8 h of culture without stimulation revealed significant lower values for monensin-treated than for brefeldin A-treated monocytes. Brefeldin A 162-173 interleukin 6 Homo sapiens 18-22 23980418-0 2013 Formal synthesis of (+)-madindoline A, a potent IL-6 inhibitor, utilizing enzymatic discrimination of quaternary carbon. madindoline A 20-37 interleukin 6 Homo sapiens 48-52 23631691-11 2013 CONCLUSIONS: We found that HP was a stronger inducer of TLR 3, 7, and 8 expression and IL-1beta, IL-6, TNF-alpha, and IFN-gamma production compared to LP and LP-der. histidylproline 27-29 interleukin 6 Homo sapiens 97-101 23626814-11 2013 The concentrations of sIL-2R, IL-6, TNF-alpha, IFN-gamma in COPD patients with TB were significantly higher than those in COPD patients without TB. Terbium 79-81 interleukin 6 Homo sapiens 30-34 25201048-0 2015 Sphingosine-1-phosphate mediates COX-2 expression and PGE2 /IL-6 secretion via c-Src-dependent AP-1 activation. sphingosine 1-phosphate 0-23 interleukin 6 Homo sapiens 60-64 25201048-1 2015 Sphingosine-1-phosphate (S1P) has been shown to regulate cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2 ) expression and IL-6 secretion in various respiratory diseases. sphingosine 1-phosphate 0-23 interleukin 6 Homo sapiens 122-126 25243457-11 2015 Further preclinical study might reveal the potential use of zerumbone as a chemotherapeutic agent for hormone refractory prostate cancer where IL-6/JAK2/STAT3 signaling is aberrantly active and may be combined with PTX. zerumbone 60-69 interleukin 6 Homo sapiens 143-147 11449408-8 2001 The spontaneous intracellular production in molecules of equivalent soluble fluorochrome units (MESF) of IL-1beta, IL-6, and TNF-alpha after 8 h of culture was higher in brefeldin A than in monensin-inhibited monocytes. Brefeldin A 170-181 interleukin 6 Homo sapiens 115-119 26090459-5 2015 33-Hydroxyepigambogic acid and 35-hydroxyepigambogic acid exhibited about 1 muM IC50 values against JAK2/JAK3 kinases and less than 1 muM IC50 values against NCI-H1650 cell which autocrined IL-6. 35-Hydroxyepigambogic acid 31-57 interleukin 6 Homo sapiens 190-194 11449408-9 2001 The LPS-stimulated intracellular production of IL-1beta, IL-6, and TNF-alpha was increased in brefeldin A-inhibited monocytes. Brefeldin A 94-105 interleukin 6 Homo sapiens 57-61 23593388-9 2013 Finally, the chromatin association of CTR9 was specifically controlled by IL-6-induced kinase activity, because a JAK2 kinase inhibitor, AG-490, blocked its association. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 137-143 interleukin 6 Homo sapiens 74-78 11449408-10 2001 In conclusion, for flow cytometric determination of intracellular monocytic cytokines (IL-1beta, IL-6, and TNF-alpha), brefeldin A is a more potent, effective, and less toxic inhibitor of cytokine secretion than monensin. Brefeldin A 119-130 interleukin 6 Homo sapiens 97-101 11389214-2 2001 The present study was undertaken to examine the effects of exercise and carbohydrate (CHO) ingestion on interleukin-6 (IL-6) gene expression in skeletal muscle and plasma IL-6 concentration. CAV protocol 86-89 interleukin 6 Homo sapiens 104-117 25469293-2 2015 In esophageal carcinoma patients undergoing thoracic surgery, TEA combined with general anesthesia during surgery and subsequent postoperative patient-controlled epidural analgesia (PCEA) may improve plasma cortisol (Cor), interleukin (IL)-6 and IL-17 levels and helper T-cell differentiation. tea 62-65 interleukin 6 Homo sapiens 223-241 25469293-8 2015 General anesthesia with TEA more efficiently inhibited the onset of the Th2-dominant status and decreased the plasma levels of Cor and IL-6 compared to general anesthesia alone and PCEA inhibited the Th2-dominant status more efficiently compared to PCIA. tea 24-27 interleukin 6 Homo sapiens 135-139 11389214-2 2001 The present study was undertaken to examine the effects of exercise and carbohydrate (CHO) ingestion on interleukin-6 (IL-6) gene expression in skeletal muscle and plasma IL-6 concentration. CAV protocol 86-89 interleukin 6 Homo sapiens 119-123 23439564-3 2013 PHF, DP and GA could significantly suppress the expression of allergic inflammatory cytokine IL-33-upregulated intercellular adhesion molecule (ICAM)-1, and the release of chemokines CCL2, CCL5, CXCL8 and inflammatory cytokine IL-6 from KU812 cells (all p < 0.05). Gallic Acid 12-14 interleukin 6 Homo sapiens 227-231 23439564-4 2013 With the combined use of dexamethasone (0.01 mug/mL) and GA (10 mug/mL), the suppression of ICAM-1 expression and CCL5 and IL-6 release of IL-33-activated KU812 cells were significantly greater than the use of GA alone (all p < 0.05). Gallic Acid 57-59 interleukin 6 Homo sapiens 123-127 11389214-13 2001 These data demonstrate that CHO ingestion attenuates the plasma IL-6 concentration during both cycling and running exercise. CAV protocol 28-31 interleukin 6 Homo sapiens 64-68 11389214-14 2001 However, because IL-6 mRNA expression was unaffected by CHO ingestion, it is likely that the ingestion of CHO during exercise attenuates IL-6 production by tissues other than skeletal muscle. CAV protocol 106-109 interleukin 6 Homo sapiens 137-141 26725862-3 2015 Interestingly, an MS-like autoimmune disease neuromyelitis optica (NMO) is exclusively resistant to this therapy and mediated by IL-6-dependnet PBs via producing a disease-specific autoantibody against aquaporin 4 (AQP4) on astrocyte. Lead 144-147 interleukin 6 Homo sapiens 129-133 26725862-5 2015 In addition, these PBs exhibited an IL-6-dependent survival in vitro like those in NMO. Lead 19-22 interleukin 6 Homo sapiens 36-40 22766904-12 2013 IL-6 levels were comparable between Groups 2 and 3 (p > 0.05).IL-6 levels showed good correlation with tTg levels in Group 1(p < 0.008, r = 0.471). Hydrotopotecan 106-109 interleukin 6 Homo sapiens 65-69 11278272-0 2001 Hyaluronic acid induces survival and proliferation of human myeloma cells through an interleukin-6-mediated pathway involving the phosphorylation of retinoblastoma protein. Hyaluronic Acid 0-15 interleukin 6 Homo sapiens 85-98 23497664-3 2013 We performed this survey to examine the relationship between pGDM and MS, CRP and IL-6. 9-hydroxy-11,15-dioxo-2,3,18,19-tetranorprost-5-ene-1,20-dioic acid 61-65 interleukin 6 Homo sapiens 82-86 24956549-8 2014 The MNC-derived TNF-alpha and IL-6 responses from MNCs were negatively correlated with insulin sensitivity (P < .03) and positively correlated with testosterone (P < .03) and androstenedione (P < .006) for the combined groups. Androstenedione 181-196 interleukin 6 Homo sapiens 30-34 11357886-3 2001 FK506 potently inhibited IL-6 production from PBMC stimulated with anti-CD3 and anti-CD28 monoclonal antibody (anti-CD3/CD28). Tacrolimus 0-5 interleukin 6 Homo sapiens 25-29 24222427-6 2014 Further, serum IL-6 was increased in fatigued women compared to non-fatigued women (P = 0.03), Using receiver operator curves (ROC) we determined that the posterior insula Glx/NAA ratio was the best predictor of fatigue with an overall area under the receiver operating characteristic curve (AUROC) of 79%, with a sensitivity of 81% and a specificity of 69%. N-acetylaspartate 176-179 interleukin 6 Homo sapiens 15-19 11357886-12 2001 The present study suggests that FK506 is the most effective among the four agents for the suppression of IL-6 production and IL-6-mediated autoantibody production in T cell activation related autoimmune diseases such as RA. Tacrolimus 32-37 interleukin 6 Homo sapiens 105-109 25530926-10 2014 Furthermore, undiluted daily PF latanoprost application significantly increased LDH release and IL-6 secretion as compared to PF tafluprost. pf 29-31 interleukin 6 Homo sapiens 96-100 23328479-1 2013 In this issue of Cancer Cell, Liang and colleagues demonstrated that sphingosine kinase 1, the enzyme that catalyzes formation of the biologically active lipid sphingosine 1-phosphate, drives a malicious amplification loop involving sphingosine 1-phosphate receptor 1 and the NF-kappaB/IL-6/STAT3 pathway. sphingosine 1-phosphate 160-183 interleukin 6 Homo sapiens 286-290 11357886-12 2001 The present study suggests that FK506 is the most effective among the four agents for the suppression of IL-6 production and IL-6-mediated autoantibody production in T cell activation related autoimmune diseases such as RA. Tacrolimus 32-37 interleukin 6 Homo sapiens 125-129 11327082-0 2001 Prostaglandin F2alpha upregulates interleukin-6 production in human gingival fibroblasts. Dinoprost 0-21 interleukin 6 Homo sapiens 34-47 23430672-12 2013 However, levels of IL-1beta, IL6, and IL10 in tears were significantly lower in the DEDG+S versus the DEDG-NS and in the CG+S versus the CG-NS. Sulfur 89-90 interleukin 6 Homo sapiens 29-32 23690673-3 2013 We observed that heme in a concentration range found during hemolytic episodes (3-30 muM) elicits AM to present a proinflammatory profile, stimulating reactive oxygen species (ROS) and nitric oxide (NO) generation and inducing IL-1beta, IL-6, and IL-10 secretion. Heme 17-21 interleukin 6 Homo sapiens 237-241 25086397-6 2014 The treatment of primary splenocytes with 1-GOs and 6-GOs in the presence of concanavalin A, anti-CD3 antibody and lipopolysaccharide, produced significant dose-dependent decreases of cell proliferation and IL-6 levels, revealing weak inflammatory properties of GOs which are favourable for hyperthermia cancer therapy. 6-gos 52-57 interleukin 6 Homo sapiens 207-211 25356148-8 2014 Increased IL-6 levels were correlated with the IL-6 -634G allele carriers (CG+GG genotypes). cysteinylglycine 75-77 interleukin 6 Homo sapiens 10-14 25356148-8 2014 Increased IL-6 levels were correlated with the IL-6 -634G allele carriers (CG+GG genotypes). cysteinylglycine 75-77 interleukin 6 Homo sapiens 47-51 23533638-5 2013 Together, long-acting beta2-agonists increased fluticasone-induced MKP-1 and modulated ASM synthetic function (measured by interleukin 6 (IL-6) and interleukin 8 (IL-8) secretion). Fluticasone 47-58 interleukin 6 Homo sapiens 123-136 11327082-4 2001 PGF2alpha stimulated IL-6 production in a time- and concentration-dependent fashion. Dinoprost 0-9 interleukin 6 Homo sapiens 21-25 23533638-6 2013 As IL-6 expression (like MKP-1) is cAMP/adenylate cyclase-mediated, the long-acting beta2-agonist formoterol increased IL-6 mRNA expression and secretion. Formoterol Fumarate 98-108 interleukin 6 Homo sapiens 3-7 23533638-6 2013 As IL-6 expression (like MKP-1) is cAMP/adenylate cyclase-mediated, the long-acting beta2-agonist formoterol increased IL-6 mRNA expression and secretion. Formoterol Fumarate 98-108 interleukin 6 Homo sapiens 119-123 11327082-5 2001 IL-1beta and tumor necrosis factor alpha (TNFalpha), proinflammatory cytokines, induced IL-6 production in a time-dependent manner, and PGF2alpha synergistically enhanced IL-6 production induced by IL-1beta and TNFalpha. Dinoprost 136-145 interleukin 6 Homo sapiens 171-175 23533638-7 2013 Nevertheless, when added in combination with fluticasone, beta2-agonists significantly repressed IL-6 secretion induced by tumour necrosis factor alpha (TNFalpha). Fluticasone 45-56 interleukin 6 Homo sapiens 97-101 11327082-6 2001 IL-6 mRNA was expressed in PGF2alpha-stimulated HGF, and PGF2alpha increased IL-6 mRNA levels induced by IL-1beta and TNFalpha. Dinoprost 27-36 interleukin 6 Homo sapiens 0-4 24934808-6 2014 Importantly, TAS-117 induced significant cytotoxicity in MM cells even in the presence of BM stromal cells, associated with inhibition of IL6 secretion. 3-amino-1-methyl-3-(4-(3-phenyl-5H- imidazo(1,2-c)pyrido(3,4-e)(1,3)oxazin-2-yl)phenyl)cyclobutanol 13-20 interleukin 6 Homo sapiens 138-141 11327082-6 2001 IL-6 mRNA was expressed in PGF2alpha-stimulated HGF, and PGF2alpha increased IL-6 mRNA levels induced by IL-1beta and TNFalpha. Dinoprost 57-66 interleukin 6 Homo sapiens 77-81 24792436-3 2014 Tylvalosin treatment markedly decreased IL-8, IL-6, IL-1beta, PGE2, TNF-alpha and NO levels in vitro and in vivo. tylvalosin 0-10 interleukin 6 Homo sapiens 46-50 11327082-7 2001 Fluprostenol, a selective FP receptor agonist, could mimic PGF2alpha-induced IL-6 production. Dinoprost 59-68 interleukin 6 Homo sapiens 77-81 11327082-8 2001 Since FP receptors are coupled to elevation of intracellular calcium and activation of protein kinase C (PKC), the mechanism of IL-6 production by PGF2alpha was investigated using TMB-8, an inhibitor of Ca2+ mobilization from intracellular stores, and calphostin C, an inhibitor of PKC. Dinoprost 147-156 interleukin 6 Homo sapiens 128-132 23516523-7 2013 In addition, miR-181a mimics significantly inhibited increase in the levels of inflammatory factors (IL1b, IL6, and TNFa) in these cells. mir-181a 13-21 interleukin 6 Homo sapiens 107-110 11327082-9 2001 TMB-8 significantly suppressed PGF2alpha-induced IL-6 production, whereas calphostin C showed a stimulatory effect on PGF2alpha-induced IL-6 production. Dinoprost 31-40 interleukin 6 Homo sapiens 49-53 24998372-4 2014 RESULTS: Treatment with formoterol and budesonide 72 h before and after RV14 infection reduced RV14 titers and cytokine concentrations, including interleukin (IL)-1beta, IL-6 and IL-8, in supernatants and viral RNA within cells. Formoterol Fumarate 24-34 interleukin 6 Homo sapiens 170-174 11519483-2 2001 We hypothesized that IL1-beta, IL6, transforming growth factor (TGF-beta2 and platelet activating factor could increase macrophage QUIN production. Quinolinic Acid 131-135 interleukin 6 Homo sapiens 31-34 24796665-4 2014 ALA pretreatment significantly reduced apoptotic cell death of the inner and outer hair cells in cisplatin-treated organ of Corti explants and attenuated ototoxicity via marked inhibition of the increase in the expression of IL-1beta and IL-6, the phosphorylation of ERK and p38, the degradation of IkappaBalpha, the increase in intracellular levels of ROS, and the activation of caspase-3 in cisplatin-treated HEI-OC1 cells. Thioctic Acid 0-3 interleukin 6 Homo sapiens 238-242 23596884-13 2013 Isoliquiritigenin, a flavonoid monomer, could inhibited iNOS, COX-2 gene and protein expression and gene expressions of IL-1beta and IL-6, and upside-regulated gene expression of PPAR-gamma. isoliquiritigenin 0-17 interleukin 6 Homo sapiens 133-137 11403239-3 2001 The aim of the present study was to investigate the role of bone cements on IL-6 production by MG63. mg63 95-99 interleukin 6 Homo sapiens 76-80 22909087-7 2012 The DMSO-soluble component curcumin, whose occurrence within the DMSO extract was verified by HPLC/MS, reduced levels of IL-1beta, IL-6, IL-8, MMP1, MMP3 and MMP13 and both caused an up-regulation of TNF-alpha. Dimethyl Sulfoxide 4-8 interleukin 6 Homo sapiens 131-135 22909087-7 2012 The DMSO-soluble component curcumin, whose occurrence within the DMSO extract was verified by HPLC/MS, reduced levels of IL-1beta, IL-6, IL-8, MMP1, MMP3 and MMP13 and both caused an up-regulation of TNF-alpha. Dimethyl Sulfoxide 65-69 interleukin 6 Homo sapiens 131-135 22790403-8 2012 CONCLUSION: Trimetazidine proved to be effective only for reducing interleukin 6 in patients undergoing CABG. Trimetazidine 12-25 interleukin 6 Homo sapiens 67-80 24810615-8 2014 Following PZQ treatment there was an increase in the number of participants producing detectable levels of GST-specific cytokines (TNFalpha, IL-6, IL-8, IFNgamma, IL-12p70, IL-13 and IL-23p19) and also a shift in the GST-specific cytokine response towards a more pro-inflammatory phenotype than that observed before treatment. Praziquantel 10-13 interleukin 6 Homo sapiens 141-145 12094620-7 2001 In addition, interleukin-6 synthesis by these two cell lines was inhibited by genistein or daidzein; production was decreased by approximately 20% compared with the control group (P < 0.05). daidzein 91-99 interleukin 6 Homo sapiens 13-26 23889803-8 2014 In the triamcinolone group, levels of IL-6, IL-17, IP-10, platelet-derived growth factor (PDGF)-AA and VEGF were reduced significantly (p=0.012, p<0.001, p<0.001, p=0.015, and p<0.001, respectively). Triamcinolone 7-20 interleukin 6 Homo sapiens 38-42 22621841-0 2012 Synthesis and biological evaluation of 4-alkoxy-6,9-dichloro[1,2,4]triazolo[4,3-a]quinoxalines as inhibitors of TNF-alpha and IL-6. 4-alkoxy-6,9-dichloro[1,2,4]triazolo[4,3-a]quinoxalines 39-94 interleukin 6 Homo sapiens 126-130 11007619-13 2000 The pharmacologic agents (ciprofloxacin, pentoxifylline, and indomethacin) that can modulate the release of bone resorbing mediators such as PGE(2), TNF-alpha, IL-1, and IL-6 release from human monocytes. Ciprofloxacin 26-39 interleukin 6 Homo sapiens 170-174 24936296-6 2014 Related to this, the production of cytokines such as IL6 and IL10 was increased by the incubation of dendritic cells with sugar moiety. Sugars 122-127 interleukin 6 Homo sapiens 53-56 24964617-6 2014 RESULTS: The section of the IL-6, TNF-alpha, IL-1beta and IL-8 were the highest when THP-1 cells were exposed to NiSO4, DNCB and K2Cr2O7 for 6h, PPDA and TDI for 12h. nickel sulfate 113-118 interleukin 6 Homo sapiens 28-32 24964617-6 2014 RESULTS: The section of the IL-6, TNF-alpha, IL-1beta and IL-8 were the highest when THP-1 cells were exposed to NiSO4, DNCB and K2Cr2O7 for 6h, PPDA and TDI for 12h. Dinitrochlorobenzene 120-124 interleukin 6 Homo sapiens 28-32 24964617-7 2014 The production of IL-6 were approximately 40, 25, 20, 50 and 50 times for five kinds chemical allergens NiSO4, DNCB, K2Cr2O7, PPDA and TDI respectively at the optimum time points and the optimal concentration compared to the control group. nickel sulfate 104-109 interleukin 6 Homo sapiens 18-22 24964617-7 2014 The production of IL-6 were approximately 40, 25, 20, 50 and 50 times for five kinds chemical allergens NiSO4, DNCB, K2Cr2O7, PPDA and TDI respectively at the optimum time points and the optimal concentration compared to the control group. Dinitrochlorobenzene 111-115 interleukin 6 Homo sapiens 18-22 22180563-12 2012 Pre-LPS IL-6 was greater (P = 0.027) in chromium-supplemented steers than in control steers. Chromium 40-48 interleukin 6 Homo sapiens 8-12 22180563-13 2012 Post-LPS IL-6 increased in both treatments and was greater (P < 0.001) in chromium-supplemented than in control steers. Chromium 77-85 interleukin 6 Homo sapiens 9-13 11067924-10 2000 This interaction will tend to retain IL-6 close to its sites of secretion in the tissues by binding to heparin-like glycosaminoglycans, thus favoring a paracrine mode of activity. Glycosaminoglycans 116-134 interleukin 6 Homo sapiens 37-41 22475649-5 2012 G4-OH and Cel/G4-OH suppressed lipopolysaccharide-mediated release of proinflammatory mediators, such as nitric oxide and IL-6, but not TNF-alpha, without reducing microglial cell viability, while Cel/G4-NH(2) potentiated cytotoxicity and cytokine release. N(6)-(1-carboxyethyl)lysine 10-13 interleukin 6 Homo sapiens 122-126 24049649-5 2012 Nevertheless, several parameters participating in oxidative stress (increased ROS production and apoptosis, decreased total thiol content) were observed in IB3-1 cells cultured in hypertonic environment as compared to S9 cells and were inhibited by diphenyleneiodonium (DPI), a well-known inhibitor of NOXs; besides, increased production of the proinflammatory cytokines IL-6 and IL-8 by IB3-1 cells was also inhibited by DPI as compared to S9 cells. diphenyleneiodonium 249-268 interleukin 6 Homo sapiens 371-375 11052920-0 2000 Effect of ciprofloxacin on the activation of the transcription factors nuclear factor kappaB, activator protein-1 and nuclear factor-interleukin-6, and interleukin-6 and interleukin-8 mRNA expression in a human endothelial cell line. Ciprofloxacin 10-23 interleukin 6 Homo sapiens 133-146 24087989-9 2014 The levels of plasma C-reactive protein, interleukin-6, and fibrinogen were significantly decreased in the LMWH group. Heparin, Low-Molecular-Weight 107-111 interleukin 6 Homo sapiens 41-54 11052920-2 2000 We have shown previously that ciprofloxacin decreases the accumulation of interleukin (IL)-6 protein from a human endothelial cell line, whilst IL-8 protein production was increased. Ciprofloxacin 30-43 interleukin 6 Homo sapiens 74-92 24251570-3 2014 In this paper, targeting peptides are conjugated to antisense interleukin-6 via a copper (I) catalyzed alkyne-azide cycloaddition click reaction. cuprous ion 82-92 interleukin 6 Homo sapiens 62-75 24251570-3 2014 In this paper, targeting peptides are conjugated to antisense interleukin-6 via a copper (I) catalyzed alkyne-azide cycloaddition click reaction. alkyne-azide 103-115 interleukin 6 Homo sapiens 62-75 22584760-10 2012 Circulating 1,25-dihydroxyvitamin D was directly related to glomerular filtration rate (R(2) = .227; p < .001) and inversely related to interleukin 6 (R(2) = .105; p = .012). 1,25-dihydroxyvitamin D 12-35 interleukin 6 Homo sapiens 139-152 11052920-6 2000 Ciprofloxacin decreased IL-6 mRNA (P<0.05) and increased IL-8 mRNA (P<0.05) expression. Ciprofloxacin 0-13 interleukin 6 Homo sapiens 24-28 22894740-0 2012 High doses of in vitro beta-carotene, alpha-tocopherol and ascorbic acid induce oxidative stress and secretion of IL-6 in peripheral blood mononuclear cells from healthy donors. beta Carotene 23-36 interleukin 6 Homo sapiens 114-118 11052920-9 2000 The study shows that ciprofloxacin-mediated decreased IL-6 release by a human endothelial cell line is reflected by decreased mRNA expression and decreased NF-IL-6 but not NFkappaB or AP-1 activation. Ciprofloxacin 21-34 interleukin 6 Homo sapiens 54-58 10884313-4 2000 Pretreatment of astrocytes with P2 receptor antagonists, including suramin and periodate oxidized ATP (oATP), resulted in a significant downregulation of IL-1beta-stimulated expression of nitric oxide, tumor necrosis factor (TNFalpha), and IL-6 at both the protein and mRNA levels, without affecting cell viability. Suramin 67-74 interleukin 6 Homo sapiens 240-244 22396222-8 2012 In addition to the interference of artemisinic acid with adipogenesis, artemisinic acid significantly attenuated tumor necrosis factor-alpha-induced secretion of interleukin-6 by undifferentiated hAMSCs, thus influencing insulin resistance and the inflammatory state characterizing obesity. artemisic acid 71-87 interleukin 6 Homo sapiens 162-175 23360079-0 2014 Effects of alpha lipoic acid and its R+ enantiomer supplemented to hyperbaric oxygen therapy on interleukin-6, TNF-alpha and EGF production in chronic leg wound healing. Thioctic Acid 11-28 interleukin 6 Homo sapiens 96-109 11108572-5 2000 Among OA patients in whom remarkable improvement was noted in hydrarthrosis, the synovial fluid IL-6 and IL-8 levels at the initial examination were relatively higher, and were markedly decreased after treatment with sodium hyaluronate (NaHA). Hyaluronic Acid 217-235 interleukin 6 Homo sapiens 96-100 24318992-7 2014 The combined results showed that association between IL-6-174 G/C polymorphism and risk of HCC was significant under additive model (CC vs. GG: OR 0.36; 95% CI, 0.16, 0.85) and recessive model (GG+CG vs. CC: OR 2.82; 95% CI 1.26, 6.28). cysteinylglycine 197-199 interleukin 6 Homo sapiens 53-57 24484680-5 2014 RESULTS: In a linear mixed-effect model adjusted for baseline demographic and clinical parameters, each pg/mL increase in IL-6 over time was associated with a decrease in PA levels of 0.001 /2-y (P = 0.003 for IL-6 x time interaction). Protactinium 171-173 interleukin 6 Homo sapiens 122-126 22267101-8 2012 Additionally, the levels of IL-6 and IL-8 mRNA induced by TNF-alpha were significantly suppressed by the addition of cinobufocini. cinobufocini 141-153 interleukin 6 Homo sapiens 28-32 22412070-10 2012 Intake of sugar-sweetened but not artificially sweetened beverages was significantly associated with increased plasma triglycerides, C-reactive protein, interleukin-6, and tumor necrosis factor receptors 1 and 2 and decreased high-density lipoprotein, lipoprotein(a), and leptin (P<0.02). Sugars 10-15 interleukin 6 Homo sapiens 153-166 24484680-6 2014 PA remained associated with the rate of change in IL-6 even after controlling for extracellular water and fat mass. Protactinium 0-2 interleukin 6 Homo sapiens 50-54 10833370-8 2000 The TPA-induced production of IL-6 was inhibited by 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine and sphyngosine, suggesting the involvement of a protein kinase C-dependent pathway. sphyngosine 103-114 interleukin 6 Homo sapiens 30-34 24484680-7 2014 Changes in PA over time were associated with inverse linear changes in IL-6 (adjusted r = -0.32; P = 0.005) and consequently with mortality risk. Protactinium 11-13 interleukin 6 Homo sapiens 71-75 24198583-14 2012 A significant (P < 0.05) elevation of IL-6 was seen immediately post-exercise and 12 hours post-exercise with both the CHO-alone and 4:1 CHO/PRO solutions. Proline 144-147 interleukin 6 Homo sapiens 41-45 10760560-4 2000 METHODS: We examined, in nine normal volunteers, the in vitro effects of moclobemide on the production of interleukin-6 (IL-6), IL-8, tumor necrosis factor-alpha (TNFalpha), interferon-gamma (IFNgamma), IL-10 and the IL-1 receptor antagonist (IL-1RA) by diluted whole blood stimulated or not with lipopolysaccharide (LPS)+phytohemagglutinin (PHA). Moclobemide 73-84 interleukin 6 Homo sapiens 106-119 22108589-0 2012 Arecoline decreases interleukin-6 production and induces apoptosis and cell cycle arrest in human basal cell carcinoma cells. Arecoline 0-9 interleukin 6 Homo sapiens 20-33 22108589-1 2012 Arecoline, the most abundant areca alkaloid, has been reported to decrease interleukin-6 (IL-6) levels in epithelial cancer cells. Arecoline 0-9 interleukin 6 Homo sapiens 75-88 22108589-1 2012 Arecoline, the most abundant areca alkaloid, has been reported to decrease interleukin-6 (IL-6) levels in epithelial cancer cells. Arecoline 0-9 interleukin 6 Homo sapiens 90-94 22108589-2 2012 Since IL-6 overexpression contributes to the tumorigenic potency of basal cell carcinoma (BCC), this study was designed to investigate whether arecoline altered IL-6 expression and its downstream regulation of apoptosis and the cell cycle in cultured BCC-1/KMC cells. Arecoline 143-152 interleukin 6 Homo sapiens 161-165 22108589-4 2012 After 24h exposure, arecoline inhibited BCC-1/KMC cell growth and decreased IL-6 production in terms of mRNA expression and protein secretion, but had no effect on HaCaT cells. Arecoline 20-29 interleukin 6 Homo sapiens 76-80 22108589-8 2012 This study demonstrates that arecoline has potential for preventing BCC tumorigenesis by reducing levels of the tumor cell survival factor IL-6, increasing levels of the tumor suppressor factor p53, and eliciting cell cycle arrest, followed by apoptosis. Arecoline 29-38 interleukin 6 Homo sapiens 139-143 24405838-7 2014 TNF-alpha, IL-6 and MCP-1 decreased with spironolactone (p=0.002, p=0.02 and p=0.02 vs. baseline, respectively), but not with furosemide. Spironolactone 41-55 interleukin 6 Homo sapiens 11-15 24456369-0 2014 Drug design targeting protein-protein interactions (PPIs) using multiple ligand simultaneous docking (MLSD) and drug repositioning: discovery of raloxifene and bazedoxifene as novel inhibitors of IL-6/GP130 interface. Raloxifene Hydrochloride 145-155 interleukin 6 Homo sapiens 196-200 24456369-0 2014 Drug design targeting protein-protein interactions (PPIs) using multiple ligand simultaneous docking (MLSD) and drug repositioning: discovery of raloxifene and bazedoxifene as novel inhibitors of IL-6/GP130 interface. bazedoxifene 160-172 interleukin 6 Homo sapiens 196-200 24456369-2 2014 We report here the discovery of raloxifene and bazedoxifene as novel inhibitors of IL-6/GP130 protein-protein interactions (PPIs) using multiple ligand simultaneous docking (MLSD) and drug repositioning approaches. Raloxifene Hydrochloride 32-42 interleukin 6 Homo sapiens 83-87 10687873-6 2000 However, 4 microM of fangchinoline and 6 microM of tetrandrine showed 63 and 86% of inhibitions on hIL-6 activity, respectively. tetrandrine 51-62 interleukin 6 Homo sapiens 99-104 24456369-2 2014 We report here the discovery of raloxifene and bazedoxifene as novel inhibitors of IL-6/GP130 protein-protein interactions (PPIs) using multiple ligand simultaneous docking (MLSD) and drug repositioning approaches. bazedoxifene 47-59 interleukin 6 Homo sapiens 83-87 24456369-4 2014 Similarity searches of virtual hits on drug databases identified raloxifene and bazedoxifene as potential inhibitors of IL-6/GP130 interaction. Raloxifene Hydrochloride 65-75 interleukin 6 Homo sapiens 120-124 24456369-4 2014 Similarity searches of virtual hits on drug databases identified raloxifene and bazedoxifene as potential inhibitors of IL-6/GP130 interaction. bazedoxifene 80-92 interleukin 6 Homo sapiens 120-124 24456369-6 2014 The identified drugs represent a new class of lead compounds with piperidine, benzothiophene, and indole scaffolds to inhibit IL-6 induced homodimerization of GP130. piperidine 66-76 interleukin 6 Homo sapiens 126-130 21925926-13 2012 Taken together, LPA may be a potent inducer of osteolytic factor IL-6 and IL-8 in OSCC. lysophosphatidic acid 16-19 interleukin 6 Homo sapiens 65-69 21925926-14 2012 LPA-induced IL-6 and IL-8 exerted propound effects on RANKL expression in osteoblast and thereby promoted osteoclast formation from osteoclast precursors. lysophosphatidic acid 0-3 interleukin 6 Homo sapiens 12-16 10675272-5 2000 In addition to TNF, melanin inhibited production of interleukin (IL)-1beta, IL-6, and IL-10 but not granulocyte-macrophage colony-stimulating factor by the LPS-stimulated monocytes. Melanins 20-27 interleukin 6 Homo sapiens 76-80 22844504-6 2012 In both models MC-12: reversed dose-dependently colonic inflammation; inhibited by up to 47% myeloperoxidase activity; had a minimal effect on cytoplasmic phospholipase A(2); reduced significantly the induced levels of TNF-alpha, IFN-gamma, IL-1beta, IL-6 and IL-10, returning them to baseline. mc-12 15-20 interleukin 6 Homo sapiens 251-255 22086795-7 2011 RESULTS: Among 12 cytokines, IL-6, IL-8, IL-10, and TNF-alpha were significantly elevated in patients with resistance against lamivudine compared with patients maintaining response. Lamivudine 126-136 interleukin 6 Homo sapiens 29-33 24325143-8 2014 aPL-induced inhibition of trophoblast migration was partially reversed by HCQ, even though HCQ significantly increased secretion of pro-migratory IL-6 to greater than baseline. Hydroxychloroquine 91-94 interleukin 6 Homo sapiens 146-150 24325143-10 2014 CONCLUSION: Hydroxychloroquine reversed the aPL-inhibition of trophoblast IL-6 secretion and partially limited aPL-inhibition of cell migration. Hydroxychloroquine 12-30 interleukin 6 Homo sapiens 74-78 24032470-0 2014 Corticosteroids inhibit sphingosine 1-phosphate-induced interleukin-6 secretion from human airway smooth muscle via mitogen-activated protein kinase phosphatase 1-mediated repression of mitogen and stress-activated protein kinase 1. sphingosine 1-phosphate 24-47 interleukin 6 Homo sapiens 56-69 24296301-10 2014 Solvent (DMSO) controls exhibited statistically significantly decreased responses compared with non-treated controls for IL-6 release and IL-8 mRNA expression, but these responses were not consistent across experiments and times. Dimethyl Sulfoxide 9-13 interleukin 6 Homo sapiens 121-125 10675272-6 2000 Melanin was equally effective in inhibiting production of TNF by monocytes stimulated with the purified protein derivative of Mycobacterium tuberculosis and production of IL-6 by IL-1alpha-stimulated human fibroblasts and endothelial cells. Melanins 0-7 interleukin 6 Homo sapiens 171-175 21878375-3 2011 Data showed that DMSO decreased induced IL-6 and MCP-1 secretions in a dose-dependent manner (P<0.05), but not IL-8; these effects were cell development- and stimulus- independent. Dimethyl Sulfoxide 17-21 interleukin 6 Homo sapiens 40-44 21878375-5 2011 DMSO at 0.5% decreased significantly mRNA levels of 14 proteins involved in the inflammatory response (including IL-6, IL-1alpha, IL-1beta, and COX-2). Dimethyl Sulfoxide 0-4 interleukin 6 Homo sapiens 113-117 25530684-7 2014 KEY RESULTS: Treating A549 with EtOH or EtP reduced substantially the cytokine-induced release of IL-8 and IL-6. ethyl pyruvate 40-43 interleukin 6 Homo sapiens 107-111 10619928-6 1999 Exposure of leukocytes to Co2+ ion increased the release of TNF-alpha, IL-6, and PGE2. Cobalt(2+) 26-30 interleukin 6 Homo sapiens 71-75 21910725-13 2011 Among subjects with sarcoidosis there was a significant relation between the spontaneous PBMC production of IL-6, IL-10 and IL-12 and the NAHA levels at home. naha 138-142 interleukin 6 Homo sapiens 108-112 10616194-4 1999 Using synovial cells from patients with rheumatoid arthritis (RA), we demonstrated that CD44 crosslinking and binding to hyaluronan augmented IL-6 production. Hyaluronic Acid 121-131 interleukin 6 Homo sapiens 142-146 21535317-3 2011 In the present study, we report a significant correlation between aPKClambda/iota and IL-6 proteins in prostate cancer tissue by immunohistochemical staining. iota 77-81 interleukin 6 Homo sapiens 86-90 24261780-5 2014 Quantification of serum IL-6 might be useful in diagnosis and evaluation of CPN. cpn 76-79 interleukin 6 Homo sapiens 24-28 25376195-0 2014 Indoxyl sulfate induces IL-6 expression in vascular endothelial and smooth muscle cells through OAT3-mediated uptake and activation of AhR/NF-kappaB pathway. Indican 0-15 interleukin 6 Homo sapiens 24-28 25376195-2 2014 The present study aimed to determine the effects of indoxyl sulfate (IS) on IL-6 expression in vascular cells. Indican 52-67 interleukin 6 Homo sapiens 76-80 25376195-2 2014 The present study aimed to determine the effects of indoxyl sulfate (IS) on IL-6 expression in vascular cells. Indican 69-71 interleukin 6 Homo sapiens 76-80 21640152-13 2011 In the in vitro model, IFN-alpha, IL-1beta, IL-6, IL-10, IP-10 and MIP-1alpha levels were significantly higher when measured at 6 and 24 h in cultures stimulated with Fluvax( ) compared with alternative 2010 TIV preparations. fluvax 167-173 interleukin 6 Homo sapiens 44-48 21051589-9 2011 Results of reporter assays, immunoblot assays, and ELISA revealed that the heat shock protein 90 (Hsp90) inhibitors 17-allyamino-17-demethoxygeldanamycin and geldanamycin blocked IL-6-induced PSA gene expression. 17-allyamino-17-demethoxygeldanamycin 116-153 interleukin 6 Homo sapiens 179-183 10616194-5 1999 Briefly, we found that (a) rheumatoid synovial cells highly expressed CD44; (b) crosslinking of CD44 augmented IL-6 production and its mRNA transcription; (c) hyaluronan, especially when fragmented, also increased IL-6 production; and (d) CD44 activated the transcription factor activator protein-1 and CAMP-responsive element binding protein. Hyaluronic Acid 159-169 interleukin 6 Homo sapiens 214-218 10657523-4 1999 Stimulation of IL-6 by SP occurred in a conventional receptor-mediated manner as demonstrated by its differential release by fragments SP 4-11 and SP 1-4 and by the blockage of IL-6 release with the non-peptide, NK-1 receptor antagonist, CP-99 994. cp-99 238-243 interleukin 6 Homo sapiens 15-19 21345936-6 2011 Polysulphated cyclodextrins MA-CDPS, HP-CDPS, CE-CDPS and CDPS at 5 microg/ml concentrations, on the other hand, significantly induced aggrecan production and repressed IL-6 release by the chondrocytes in culture. ce-cdps 46-53 interleukin 6 Homo sapiens 169-173 21533553-6 2011 Inhibition of COX-2 by NS-398, a selective inhibitor of COX-2, significantly repressed the cytotoxicity, as well as secretion of IL-6 and IL-8 induced by CoCl(2). cocl 154-158 interleukin 6 Homo sapiens 129-133 20158569-8 2011 The standard anti-inflammatory drugs aspirin and indomethacin (Indo) reduced the synergistic IL-6 production by 60%. Indomethacin 49-61 interleukin 6 Homo sapiens 93-97 24564598-6 2014 C-reactive protein (CRP), DAS28, and interleukin (IL)-6 negatively correlated with androstenedione response to ACTH 1-24. Androstenedione 83-98 interleukin 6 Homo sapiens 37-55 20158569-8 2011 The standard anti-inflammatory drugs aspirin and indomethacin (Indo) reduced the synergistic IL-6 production by 60%. Indomethacin 63-67 interleukin 6 Homo sapiens 93-97 10567414-12 1999 In contrast, replacement of the IL-6 NF-kappaB sequence by the IL-2 CD28RE motif strongly reduced the responsiveness of the IL-6 promoter. cd28re 68-74 interleukin 6 Homo sapiens 32-36 21166606-7 2011 The mean serum concentrations of IL-6 and CRP and the ESR had increased 1 year after PTX (p < 0.001, p < 0.01, and p < 0.001, respectively) in parallel with a decrease in cardiac function and an increase in circulating NT-proBNP. ptx 85-88 interleukin 6 Homo sapiens 33-37 20604677-4 2011 The results indicated that beta-eudesmol inhibited the production and expression of interleukin (IL)-6 on phorbol 12-myristate 13-acetate and calcium ionophore A23187-stimulated human mast cell (HMC). beta-eudesmol 27-40 interleukin 6 Homo sapiens 84-102 24104193-7 2013 The results showed that alpinetin inhibited TNF-alpha, IL-6 and IL-1beta expression in LPS-stimulated human THP-1 macrophages in a dose-dependent manner. alpinetin 24-33 interleukin 6 Homo sapiens 55-59 24575132-9 2013 IL-6 reduced significantly in the omega-3 group, but the reduction of IL-6 levels in the CLA group was not significant. Linoleic Acids, Conjugated 89-92 interleukin 6 Homo sapiens 70-74 10567414-12 1999 In contrast, replacement of the IL-6 NF-kappaB sequence by the IL-2 CD28RE motif strongly reduced the responsiveness of the IL-6 promoter. cd28re 68-74 interleukin 6 Homo sapiens 124-128 23618972-10 2013 CONCLUSIONS: These results suggest that Cr(6+) may induce IL-6-mediated inflammatory responses which result in hepatic injury. CR 6 40-46 interleukin 6 Homo sapiens 58-62 10579546-10 1999 The relative decrease in exacerbated patients following haloperidol withdrawal may be indicative of a compensatory response of plasma IL-6 levels to relapse. Haloperidol 56-67 interleukin 6 Homo sapiens 134-138 23650203-1 2013 SCOPE: We aimed to study the effects of free fatty acids (FFAs) alone and combined with the exercise mimetics adrenaline and 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) in the production of IL6, IL15 and Irisin in muscle cells, using a time-sequential model. acadesine 125-170 interleukin 6 Homo sapiens 200-203 23650203-1 2013 SCOPE: We aimed to study the effects of free fatty acids (FFAs) alone and combined with the exercise mimetics adrenaline and 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) in the production of IL6, IL15 and Irisin in muscle cells, using a time-sequential model. acadesine 172-177 interleukin 6 Homo sapiens 200-203 23743311-11 2013 CONCLUSION: Increasing IP-10 and IL-6 production by BAL cells is associated with non-cavitary TB in patients who present with radiographically advanced TB. Terbium 94-96 interleukin 6 Homo sapiens 33-37 23743311-11 2013 CONCLUSION: Increasing IP-10 and IL-6 production by BAL cells is associated with non-cavitary TB in patients who present with radiographically advanced TB. Terbium 152-154 interleukin 6 Homo sapiens 33-37 23743311-12 2013 IP-10 and IL-6 may reflect an effective T-helper 1 immune control pathway for TB, attenuating tuberculous lung destruction. Terbium 78-80 interleukin 6 Homo sapiens 10-14 21348878-4 2011 Accordingly, this review examines how varying degrees of CR-induced weight loss (i.e., >10%, 5-10%, and <5% from baseline) impact plasma levels and expression of adiponectin, leptin, resistin, interleukin 6 (IL-6), interleukin 8 (IL-8), monocyte chemotactic protein 1 (MCP-1), and retinol-binding protein 4 (RBP-4). Chromium 57-59 interleukin 6 Homo sapiens 199-212 21348878-4 2011 Accordingly, this review examines how varying degrees of CR-induced weight loss (i.e., >10%, 5-10%, and <5% from baseline) impact plasma levels and expression of adiponectin, leptin, resistin, interleukin 6 (IL-6), interleukin 8 (IL-8), monocyte chemotactic protein 1 (MCP-1), and retinol-binding protein 4 (RBP-4). Chromium 57-59 interleukin 6 Homo sapiens 214-218 10528891-8 1999 In vitro blocking of an interleukin-6-dependent pathway with either a JAK inhibitor (tyrphostin, AG490) or STAT3 dominant negative (STAT3-DN) reduced expression of Bcl-xL (an antiapoptosis protein), increased spontaneous apoptosis, and enhanced sensitivity to Fas-mediated apoptosis. Tyrphostins 85-95 interleukin 6 Homo sapiens 24-37 22531121-7 2011 The concentrations of IL-6, IL-8, VEGF and MMP-2 protein in the culture supernatant of MKN-45P were significantly higher than those of MKN-45. mkn-45p 87-94 interleukin 6 Homo sapiens 22-26 23564008-0 2013 The concentrations of IL-8 and IL-6 in gingival crevicular fluid during nickel-chromium alloy porcelain crown restoration. Chromium 79-87 interleukin 6 Homo sapiens 31-35 10627728-3 1999 These increased levels of interleukin-6 were associated with a decrease in bone mineral density associated with polyethylene wear and with radiologic osteolysis in some patients. Polyethylene 112-124 interleukin 6 Homo sapiens 26-39 23331485-11 2013 CONCLUSION: The COX inhibitors indomethacin and celecoxib reduce the expression of inflammatory factors, such as COX-2 and IL-6, in FLS from the TMJ via suppression of PGE2 production. Indomethacin 31-43 interleukin 6 Homo sapiens 123-127 23624712-0 2013 4-Chlorobenzoyl berbamine, a novel berbamine derivative, induces apoptosis in multiple myeloma cells through the IL-6 signal transduction pathway and increases FOXO3a-Bim expression. 4-chlorobenzoylberbamine 0-25 interleukin 6 Homo sapiens 113-117 22125636-6 2011 In PBMC from healthy donors, budesonide alone inhibited IP-10 and IL-6 production induced by imiquimod in a concentration-dependent manner and the degree of inhibition was amplified when budesonide and formoterol were used in combination. Formoterol Fumarate 202-212 interleukin 6 Homo sapiens 66-70 21792817-0 2010 Inverse correlation between plasma Beta-carotene and interleukin-6 in patients with advanced coronary artery disease. beta Carotene 35-48 interleukin 6 Homo sapiens 53-66 21054880-5 2010 We have examined whether saturated nonesterified fatty acids (NEFA) and insulin, which increase in concentration with developing insulin resistance, can trigger the production of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha in human monocytes. saturated nonesterified fatty acids 25-60 interleukin 6 Homo sapiens 179-197 23656327-3 2013 Synthetic modifications of the pyrimido[5,4-b]indole scaffold at the carboxamide, N-3, and N-5 positions revealed differential TLR4 dependent production of NFkappaB and type I interferon associated cytokines, IL-6 and interferon gamma-induced protein 10 (IP-10) respectively. 5H-pyrimido[5,4-b]indole 31-52 interleukin 6 Homo sapiens 209-213 10522805-0 1999 The beta-adrenoceptor agonist clenbuterol is a potent inhibitor of the LPS-induced production of TNF-alpha and IL-6 in vitro and in vivo. Clenbuterol 30-41 interleukin 6 Homo sapiens 111-115 23778483-7 2013 RESULTS: We demonstrated that in peripheral blood mononuclear cells from healthy volunteers and in systemic lupus erythematosus and rheumatoid arthritis patients, there was a significant reduction in the IL-6, IL-17 and IL-22 supernatant levels after adding hydroxychloroquine. Hydroxychloroquine 258-276 interleukin 6 Homo sapiens 204-208 23778483-8 2013 CONCLUSIONS Our in vitro results demonstrated that hydroxychloroquine inhibits IL-6, IL-17 and IL-22 production and contributes to a better understanding of the mechanism of action of this medication. Hydroxychloroquine 51-69 interleukin 6 Homo sapiens 79-83 20652679-2 2010 METHODS: IL-6-stimulated expression of the genes for acute-phase response markers serum amyloid A (SAA1, SAA2) and haptoglobin (HP) in the human hepatocarcinoma cell line HepG2 were quantified after modulation of AMPK activity by pharmacological agonists (5-amino-4-imidazole-carboxamideriboside [AICAR], metformin) or by using small interfering (si) RNA transfection. acadesine 297-302 interleukin 6 Homo sapiens 9-13 10522805-1 1999 OBJECTIVE AND DESIGN: To investigate the suppressive effects of the beta-agonist clenbuterol on the release of TNF-alpha and IL-6 in a lipopolysaccharide (LPS)-model of inflammation, both in vitro and in vivo. Clenbuterol 81-92 interleukin 6 Homo sapiens 125-129 10522805-6 1999 CONCLUSIONS: The beta-agonist clenbuterol very potently suppresses the LPS-induced release of the pro-inflammatory cytokines TNF-alpha and IL-6 both in vitro and in vivo. Clenbuterol 30-41 interleukin 6 Homo sapiens 139-143 10405161-2 1999 Hyaluronic acid with a molecular weight above 1.2 MDa (HMW-HA) inhibits the AGE-induced activation of the transcription factor NF-kappaB and the NF-kappaB-regulated cytokines interleukin-1alpha, interleukin-6 and tumor necrosis factor-alpha. Hyaluronic Acid 0-15 interleukin 6 Homo sapiens 195-240 20334961-6 2010 As expected, the addition of IL-6 to the models attenuated the association of serum selenium with RDW, as low antioxidant levels are known to upregulate IL-6. Selenium 84-92 interleukin 6 Homo sapiens 29-33 20334961-6 2010 As expected, the addition of IL-6 to the models attenuated the association of serum selenium with RDW, as low antioxidant levels are known to upregulate IL-6. Selenium 84-92 interleukin 6 Homo sapiens 153-157 20334961-9 2010 CONCLUSION: Serum selenium is an independent predictor of RDW and may potentially mediate effects on RDW through IL-6. Selenium 18-26 interleukin 6 Homo sapiens 113-117 23247631-6 2013 But silymarin combined with antiviral drug or antiviral drug and protection liver drugs significantly reduced the level of serum transaminases, hepatic fibrosis markers and serum TGF-beta1, TNF-alpha, IL-6 versus antiviral drug or protection liver drugs. Silymarin 4-13 interleukin 6 Homo sapiens 201-205 22653750-5 2013 Therefore, we compared the potency of 13 different glucan preparations to induce in vitro production of IL-1beta, IL-6, IL-8 and TNF-alpha in human, whole blood cultures. Glucans 51-57 interleukin 6 Homo sapiens 114-118 10505115-7 1999 Likewise, the CpG oligodeoxynucleotides 1760 (phosphorothioate) and 2059 (unmodified) induced IL-6 synthesis, but the corresponding control oligonucleotides 1908 and 2077 did not CpG DNA and LPS enhanced IL-6 synthesis synergistically. Parathion 46-62 interleukin 6 Homo sapiens 94-98 24348674-0 2013 Modulatory effect of 1,25-dihydroxyvitamin D 3 on IL1 beta -induced RANKL, OPG, TNF alpha , and IL-6 expression in human rheumatoid synoviocyte MH7A. 1,25-dihydroxyvitamin D 21-44 interleukin 6 Homo sapiens 96-100 10505115-7 1999 Likewise, the CpG oligodeoxynucleotides 1760 (phosphorothioate) and 2059 (unmodified) induced IL-6 synthesis, but the corresponding control oligonucleotides 1908 and 2077 did not CpG DNA and LPS enhanced IL-6 synthesis synergistically. Parathion 46-62 interleukin 6 Homo sapiens 204-208 24030317-6 2013 Niflumic acid (NFA), an hCLCA blocker, reduced histamine-induced IL-6 and IL-8 expression. Niflumic Acid 0-13 interleukin 6 Homo sapiens 65-69 24030317-6 2013 Niflumic acid (NFA), an hCLCA blocker, reduced histamine-induced IL-6 and IL-8 expression. Niflumic Acid 15-18 interleukin 6 Homo sapiens 65-69 20615569-10 2010 JTE-013, a specific antagonist for sphingosine 1-phosphate (S1P) 2 receptors, inhibited the excretion of IL-6 from LSECs after the addition of platelets. JTE 013 0-7 interleukin 6 Homo sapiens 105-109 10215814-9 1999 The bile IL-6 concentration on day 1 after operation exhibited a significant negative correlation with the maximum serum total bilirubin concentration after hepatectomy. Bilirubin 127-136 interleukin 6 Homo sapiens 9-13 20306542-7 2010 Following stimulation of human chondrocyte alginate cultures with conditioned media from human synovial fibroblasts derived from arthritis patients, microarray analysis verified the induction of genes related to cartilage destruction (like MMP10, -12) and inflammation (like IL6, -8 and chemokines). Alginates 43-51 interleukin 6 Homo sapiens 275-278 24030317-7 2013 CONCLUSION: Histamine-induced IL-6 and IL-8 production could be attenuated by NFA, an hCLCA blocker. Niflumic Acid 78-81 interleukin 6 Homo sapiens 30-34 10050704-7 1999 Plasma interleukin-6 (measured in a 25% subsample of 196 men and 221 women) correlated significantly with age, fibrinogen, white cell count, plasma and blood viscosity, current smoking, and (in men) with low serum vitamin C levels; but not with other major risk factors or with prevalent cardiovascular disease. Ascorbic Acid 214-223 interleukin 6 Homo sapiens 7-20 24278621-8 2012 The levels of IL-1 in the thymus and spleen; INF-gamma in serum; IL-2, IL-6, and IL-10 in the thymus; and IL-10 and IFN-gamma in the spleen decreased after ZEA administration. Zearalenone 156-159 interleukin 6 Homo sapiens 71-75 23285694-0 2012 Effect of Gly-Gly-His, Gly-His-Lys and their copper complexes on TNF-alpha-dependent IL-6 secretion in normal human dermal fibroblasts. diglycyl-histidine 10-21 interleukin 6 Homo sapiens 85-89 20338972-18 2010 IL-6 level was significantly associated with free indoxyl sulfate level. Indican 50-65 interleukin 6 Homo sapiens 0-4 20423350-5 2010 KEY RESULTS: Pre-incubation with beta(2)-adrenoceptor agonists (salbutamol, salmeterol, formoterol) augmented the release and mRNA expression of IL-6 and IL-8 induced by IL-1beta and IL-1beta plus histamine, whereas NF-kappaB-dependent transcription was significantly repressed, and AP-1-dependent transcription was unaffected. Formoterol Fumarate 88-98 interleukin 6 Homo sapiens 145-149 10667331-1 1999 In HepG2 cells phosphorothioate modified antisense oligonucleotides against a sequence in the Ca2+ binding domain (AS-Ca2+) of type II sPLA2 mRNA restrained IL-6-induced synthesis of sPLA2 protein, sPLA2 mRNA (northern blot), and abolished IL-6 stimulated PGE2 release. Parathion 15-31 interleukin 6 Homo sapiens 157-161 20061317-11 2010 Multivariate analysis showed that MTAC(cr) is independently associated with dialysate IL-6 and serum albumin. Chromium 39-41 interleukin 6 Homo sapiens 86-90 22901274-11 2012 Moreover, the concentrations of TNF-alpha and IL-6 in cell culture supernatants were also significantly higher in the subjects with rs4755453GG genotype than in subjects with CG and CC genotype. cysteinylglycine 175-177 interleukin 6 Homo sapiens 46-50 10667331-1 1999 In HepG2 cells phosphorothioate modified antisense oligonucleotides against a sequence in the Ca2+ binding domain (AS-Ca2+) of type II sPLA2 mRNA restrained IL-6-induced synthesis of sPLA2 protein, sPLA2 mRNA (northern blot), and abolished IL-6 stimulated PGE2 release. Parathion 15-31 interleukin 6 Homo sapiens 240-244 10071758-8 1999 When differentiated U937 cells were incubated with both LPS and the beta-agonist clenbuterol the production of TNF-alpha and IL-6 was significantly reduced. Clenbuterol 81-92 interleukin 6 Homo sapiens 125-129 22714950-8 2012 In contrast, transfection of MSCs with miR-181a oligo enhanced expression of IL-6 and indoleamine 2,3-dioxygenase by activating p38 and JNK signaling pathways, respectively. mir-181a 39-47 interleukin 6 Homo sapiens 77-81 20207143-0 2010 Synthesis and biological evaluation of nitrogen-containing benzophenone analogues as TNF-alpha and IL-6 inhibitors with antioxidant activity. benzophenone 59-71 interleukin 6 Homo sapiens 99-103 9855318-12 1998 CONCLUSION: Indinavir concentrations were altered during IL-2 infusions, possibly by induction of IL-6. Indinavir 12-21 interleukin 6 Homo sapiens 98-102 20646353-11 2010 bLf established iron homeostasis by modulating serum IL-6 and prohepcidin synthesis, whereas ferrous sulfate increased IL-6 and failed to increase hematological parameters and prohepcidin. ferrous sulfate 93-108 interleukin 6 Homo sapiens 119-123 20136701-7 2010 In addition, melatonin significantly reduced the activation of GSK-3beta, the phosphorylation of tau protein, the glial activation and the Abeta-induced increase of TNF-alpha and IL-6 levels. UNII-042A8N37WH 139-144 interleukin 6 Homo sapiens 179-183 22537455-5 2012 We simulated the effect of combining MSD multiplex and R&D singleplex data on the association between sugar sweetened beverage (SSB) intake and IL-6 in the Health Professionals Follow-up Study (HPFS; n=1314). Sugars 106-111 interleukin 6 Homo sapiens 148-152 22537455-10 2012 The association between sugar sweetened beverage intake and IL-6 in the HPFS (+0.16 pg/mL per serving/day, p=0.02, all singleplex) was gradually attenuated as multiplex data made an increasing contribution to the data-set. Sugars 24-29 interleukin 6 Homo sapiens 60-64 9853701-10 1998 A significant correlation was found between IL-6 values and CRP, ALT, total bilirubin, GGT and creatinine, but not amylase. Bilirubin 76-85 interleukin 6 Homo sapiens 44-48 22430974-7 2012 Rilpivirine induced the release of proinflammatory cytokines (interleukin-6 and -8, monocyte chemoattractant protein 1 [MCP-1], plasminogen activator inhibitor type 1 [PAI-1]) only at very high concentrations (10 muM). Rilpivirine 0-11 interleukin 6 Homo sapiens 62-82 19878271-5 2010 In the present study of four myeloma cell lines, namely U266, NOP2, AMO1, and ILKM2, we demonstrated that baicalein not only inhibited IL-6-mediated phosphorylation of signaling proteins, such as Jak, STAT3, MAPK, and Akt, but also inhibited the expression of their target genes, such as bcl-xl. baicalein 106-115 interleukin 6 Homo sapiens 135-139 9840004-8 1998 Increased IL-6 levels were observed in cultures exposed to copper (5-19-fold compared to untreated controls), zinc (16-fold), cobalt (12-fold), nickel (10-fold) and palladium (4-fold). Nickel 144-150 interleukin 6 Homo sapiens 10-14 19878271-10 2010 Our results demonstrate that baicalein is a potent inhibitor of protein phosphorylation induced by IL-6, and thus may be a useful agent for the treatment of MM. baicalein 29-38 interleukin 6 Homo sapiens 99-103 22424696-14 2012 MMP inhibitor (UK370106) inhibited the expression of CCL20 induced by co-stimulation with fAd and IL-6 or TNF-alpha. 3-(((2,2-dimethyl-1-(((2-methoxy-1-phenylethyl)amino)carbonyl)propyl)amino)carbonyl)-6-(3-methyl-4-phenylphenyl)hexanoic acid 15-23 interleukin 6 Homo sapiens 98-102 9846284-3 1998 It is believed that imipenem may yield lower interleukin-6 (IL6) level than cephem antibiotics. Imipenem 20-28 interleukin 6 Homo sapiens 45-58 22305747-8 2012 Exposure of HT-29 colon cancer cells, which express Nox1, to DPI and DTI confirmed their inhibitory effects on steady state ROS levels, and demonstrated decreased Stat, Erk1/2, and Akt signaling mediated by IL-4, IL-6, IL-13, and IL-22, possibly due to a concomitant increase in tumor cell phosphatase activity. diphenyleneiodonium 61-64 interleukin 6 Homo sapiens 213-217 22808498-8 2012 Orthodontic structures made from chromium-cobalt, or chromium-nickel alloys in the oral cavity of these patients increased the levels of MMP-2, IL-1beta and IL-6 in oral fluid. Chromium 33-41 interleukin 6 Homo sapiens 157-161 19629677-8 2010 IL-1beta, IL-6 and TNF-alpha also significantly reduced the BCRP activity as assessed by mitoxantrone uptake experiments. Mitoxantrone 89-101 interleukin 6 Homo sapiens 10-14 9846284-3 1998 It is believed that imipenem may yield lower interleukin-6 (IL6) level than cephem antibiotics. Imipenem 20-28 interleukin 6 Homo sapiens 60-63 9846284-7 1998 Thereafter IL6 decreased gradually in both groups, however, the decrease of IL6 in the imipenem-group was faster and greater than the flomoxef-group resulting in the significantly lower level of IL6 on the 4th day after operation. Imipenem 87-95 interleukin 6 Homo sapiens 11-14 9846284-7 1998 Thereafter IL6 decreased gradually in both groups, however, the decrease of IL6 in the imipenem-group was faster and greater than the flomoxef-group resulting in the significantly lower level of IL6 on the 4th day after operation. Imipenem 87-95 interleukin 6 Homo sapiens 76-79 22193459-8 2012 Mitoxantrone accumulation was also amplified in IL-1beta-, IL-6- or TNF-alpha-treated HeLa cells and in IL-1beta-treated EPG85-257 cells. Mitoxantrone 0-12 interleukin 6 Homo sapiens 59-63 19672095-4 2010 METHODS: Rupatadine (1-50 microM) was used before stimulation by: (1) interleukin (IL)-1 to induce IL-6 from human leukemic mast cells (HMC-1 cells), (2) substance P for histamine, IL-8 and vascular endothelial growth factor release from LAD2 cells, and (3) IgE/anti-IgE for cytokine release from human cord blood-derived cultured mast cells. rupatadine 9-19 interleukin 6 Homo sapiens 99-103 9846284-7 1998 Thereafter IL6 decreased gradually in both groups, however, the decrease of IL6 in the imipenem-group was faster and greater than the flomoxef-group resulting in the significantly lower level of IL6 on the 4th day after operation. Imipenem 87-95 interleukin 6 Homo sapiens 76-79 19672095-6 2010 RESULTS: Rupatadine (10-50 microM) inhibited IL-6 release (80% at 50 microM) from HMC-1 cells, whether added 10 min or 24 h prior to stimulation. rupatadine 9-19 interleukin 6 Homo sapiens 45-49 9681394-11 1998 Upregulation of IL-6 synthesis was significantly inhibited by alphaBCG or Cytochalasin B, indicating that internalization is a prerequisite for BCG-induced upregulation of IL-6 synthesis. Cytochalasin B 74-88 interleukin 6 Homo sapiens 16-20 22101762-10 2012 Formoterol did not induce PDE4D protein at time points between 3 to 72 h, whereas it did induce and increase IL-6 secretion. Formoterol Fumarate 0-10 interleukin 6 Homo sapiens 109-113 9681394-11 1998 Upregulation of IL-6 synthesis was significantly inhibited by alphaBCG or Cytochalasin B, indicating that internalization is a prerequisite for BCG-induced upregulation of IL-6 synthesis. Cytochalasin B 74-88 interleukin 6 Homo sapiens 172-176 9684114-4 1998 RESULTS: Serum IL-6 levels measured before and after PTCD in the slowly decreasing bilirubin group ("poor" group) were significantly higher than those of the rapidly decreasing bilirubin group ("good" group). Bilirubin 83-92 interleukin 6 Homo sapiens 15-19 23018603-0 2012 Novel compound SK-1009 suppresses interleukin-6 expression through modulation of activation of nuclear factor-kappaB pathway. SK-1009 15-22 interleukin 6 Homo sapiens 34-47 23018603-2 2012 In the present study, the underlying mechanisms of a novel chemically synthesized compound SK-1009, which has suppressive properties on IL-6 production in human macrophage cells, were examined. SK-1009 91-98 interleukin 6 Homo sapiens 136-140 23018603-3 2012 SK-1009 suppressed IL-6 mRNA levels in human colon cancer cells. SK-1009 0-7 interleukin 6 Homo sapiens 19-23 23018603-4 2012 Thus, the influence of SK-1009 on transcription factor, nuclear factor-kappaB (NF-kappaB), which is involved in expression of the IL-6 gene was assessed. SK-1009 23-30 interleukin 6 Homo sapiens 130-134 23018603-7 2012 Thus, SK-1009 exerts a potent inhibitory effect on IL-6 expression, apparently mediated by modulation of activation of NF-kappaB transcription factor. SK-1009 6-13 interleukin 6 Homo sapiens 51-55 22284780-11 2012 Specifically, apiegenin, baicalein, curcumin, EGCG, genistein, luteolin, oridonin, quercetin, and wogonin repress NF-kappaB (NF-kappaB, a proinflammatory transcription factor) and inhibit proinflammatory cytokines such as TNF-alpha and IL-6. baicalein 25-34 interleukin 6 Homo sapiens 236-240 19811770-4 2010 Using real-time quantitative PCR and ELISA analysis, we found that pretreatment with selenium (0.5-5uM) inhibited the LPS-induced expression of TGFbeta(1) and VEGF and production of these cytokines and IL-6 by PC3 cells, but did not alter the expression of TLR4 mRNA. Selenium 85-93 interleukin 6 Homo sapiens 202-206 20936184-0 2010 Induction by TNF-alpha of IL-6 and IL-8 in cystic fibrosis bronchial IB3-1 epithelial cells encapsulated in alginate microbeads. Alginates 108-116 interleukin 6 Homo sapiens 26-30 19051261-6 2009 In group B, Cr(VI) caused a decrease in the density of glucocorticoid receptors (GR) on peripheral blood mononuclear cells (PBMC) and a increase of IL-6. Chromium 12-14 interleukin 6 Homo sapiens 148-152 9684114-4 1998 RESULTS: Serum IL-6 levels measured before and after PTCD in the slowly decreasing bilirubin group ("poor" group) were significantly higher than those of the rapidly decreasing bilirubin group ("good" group). Bilirubin 177-186 interleukin 6 Homo sapiens 15-19 9510155-8 1998 FK506 also reduced CD3/CD28-induced production of IL-3, IL-4, IL-10, TNF-alpha, and IL-6 but augmented that of GM-CSF, IL-5, IFN-gamma, and IL-13. Tacrolimus 0-5 interleukin 6 Homo sapiens 84-88 20137596-0 2009 [Effects of preemptive analgesia with flurbiprofen on the blood sugar and interleukin-6 of patients after radical excision of breast cancer]. Flurbiprofen 38-50 interleukin 6 Homo sapiens 74-87 20137596-1 2009 OBJECTIVE: To investigate the effects of preemptive analgesia with flurbiprofen on the blood sugar and Interleukin-6 of patients after radical excision of breast cancer. Flurbiprofen 67-79 interleukin 6 Homo sapiens 103-116 23049614-9 2012 At the molecular level, acacetin significantly reduced IL-6, IL-8, intercellular adhesion molecule-1, and eotaxin-1 in activated BEAS-2B cells. acacetin 24-32 interleukin 6 Homo sapiens 55-59 22157665-5 2012 The CGCG compared to the PGCG showed significantly increased expression of TNF-alpha and IL-6 and decreased expression of IL-1beta by the spindle-shaped cells and increased expression of IL-1beta by the MGCs. cgcg 4-8 interleukin 6 Homo sapiens 89-93 22157665-7 2012 CONCLUSIONS: The proinflammatory cytokines TNF-alpha, IL-6 and IL-1beta seem to be involved in the growth process of PGCG and CGCG of the jaws. cgcg 126-130 interleukin 6 Homo sapiens 54-58 20137596-7 2009 CONCLUSION: Preemptive analgesia with flurbiprofen 100 mg can effectively suppress the elevation of blood sugar and serum interleukin-6 concentration after radical excision of breast cancer, and is better than postoperation analgesia. Flurbiprofen 38-50 interleukin 6 Homo sapiens 122-135 9505142-5 1998 The upregulation of IL-6 production induced by BK was abolished by the anti-inflammatory agent dexamethasone (DEX) and the phospholipase A2 (PLA2) inhibitor 4-bromphenacyl bromide (BPB). 4-bromphenacyl bromide 157-179 interleukin 6 Homo sapiens 20-24 23051896-12 2012 The cabergoline-induced IL-6 release was reduced by sulpiride. Cabergoline 4-15 interleukin 6 Homo sapiens 24-28 9464576-6 1997 Differential modulation of the production of IL-1beta and IL-6 was observed; amrinone and pimobendan enhanced the production of IL-1beta, whereas vesnarinone did not. Amrinone 77-85 interleukin 6 Homo sapiens 58-62 21925926-0 2012 Secretion of IL-6 and IL-8 from lysophosphatidic acid-stimulated oral squamous cell carcinoma promotes osteoclastogenesis and bone resorption. lysophosphatidic acid 32-53 interleukin 6 Homo sapiens 13-17 21925926-6 2012 LPA induced the secretion of IL-6 and IL-8 in oral squamous cell carcinoma (OSCC). lysophosphatidic acid 0-3 interleukin 6 Homo sapiens 29-33 21925926-7 2012 LPA-stimulated secretion of IL-6 and IL-8 is partly dependent on the LPA and EGF receptor (EGFR) pathways. lysophosphatidic acid 0-3 interleukin 6 Homo sapiens 28-32 21925926-8 2012 ERK1/2 and Akt-mediated NF-kappaB and AP-1 were responsible for the LPA-induced IL-6 and IL-8 secretion. lysophosphatidic acid 68-71 interleukin 6 Homo sapiens 80-84 21925926-10 2012 Neutralization against both human IL-6 and IL-8 suppressed osteoclast formation induced by CM derived from the LPA-stimulated OSCC. lysophosphatidic acid 111-114 interleukin 6 Homo sapiens 34-38 19362013-13 2009 The PV/PA ratio of IL-6 was higher in the sufentanil group. Sufentanil 42-52 interleukin 6 Homo sapiens 19-23 19349390-7 2009 In patients with the IL-6 GG genotype, the mean PAP value was significantly higher and PH was more common than in CG or CC patients (adjusted odds ratio, 4.32; 95% confidence interval, 1.96 to 9.54). cysteinylglycine 114-116 interleukin 6 Homo sapiens 21-25 9378980-0 1997 Molecular regulation of IL-6 activation by asbestos in lung epithelial cells: role of reactive oxygen species. Asbestos 43-51 interleukin 6 Homo sapiens 24-28 21925926-11 2012 Direct treatment with recombinant IL-6 (rIL-6) and/or soluble IL-6 receptor (sIL-6R), or IL-8 (rIL-8) reproduced the effect of the CM derived from the LPA-stimulated OSCC on osteoclast formation. lysophosphatidic acid 151-154 interleukin 6 Homo sapiens 34-38 9378980-3 1997 IL-6 induction was dependent on the intracellular redox-oxidative state, since intracellular hydroxyl scavengers and N-acetylcysteine, a precursor of glutathione, abrogated IL-6 secretion by asbestos or H2O2. Asbestos 191-199 interleukin 6 Homo sapiens 0-4 21833041-8 2011 The minor G allele of SNP rs1800796 was associated with lower plasma IL6 (geometric mean (95% CI) = 0.46 (0.41-0.51) ng/l for CG and 0.49 (0.39-0.62) ng/l for GG vs. 0.53 (0.50-0.57) ng/l for CC, P = 0.005). cysteinylglycine 126-128 interleukin 6 Homo sapiens 69-72 19442860-6 2009 Adiponectin level and Gutt"s index decreased, but IL-6 level and ACR increased gradually among NGT, PD and NDDM groups (P<0.01). nddm 107-111 interleukin 6 Homo sapiens 50-54 9378980-3 1997 IL-6 induction was dependent on the intracellular redox-oxidative state, since intracellular hydroxyl scavengers and N-acetylcysteine, a precursor of glutathione, abrogated IL-6 secretion by asbestos or H2O2. Asbestos 191-199 interleukin 6 Homo sapiens 173-177 9378980-6 1997 Stimulation of DNA binding activity to the NF-kappa B and NF-IL-6 binding sites of the IL-6 promoter by asbestos or H2O2 were inhibited by tetramethylthiourea, a hydroxyl radical scavenger. Asbestos 104-112 interleukin 6 Homo sapiens 61-65 9378980-10 1997 Taken together, the results suggest that asbestos-induced oxidative stress is involved in the activation of NF-kappa B and NF-IL-6 transcription factors, which recognize the IL-6 promoter. Asbestos 41-49 interleukin 6 Homo sapiens 126-130 9378738-10 1997 In contrast, the fluoroquinolone antibiotic ciprofloxacin, which is also a phosphodiesterase inhibitor, caused a dose-dependent inhibition of the synthesis of both tumor necrosis factor-alpha and interleukin-6 by titanium-stimulated monocytes, suggesting that ciprofloxacin suppresses the synthesis of interleukin-6 through a mechanism that is independent of cAMP. Ciprofloxacin 44-57 interleukin 6 Homo sapiens 302-315 19241441-5 2009 Evodiamine and rutaecarpine decreased the LIGHT-induced production of ROS, IL-8, monocyte chemoattractant protein-1 (MCP-1), TNF-alpha, and IL-6, as well as the expression of chemokine receptor (CCR) 1, CCR2 and ICAM-1 and the phosphorylation of the ERK 1/2 and p38 MAPK. rutecarpine 15-27 interleukin 6 Homo sapiens 140-144 21710624-10 2011 Indomethacin diminished the accumulation of microglia/macrophages and IL-6 production after H/I. Indomethacin 0-12 interleukin 6 Homo sapiens 70-74 21866460-10 2011 When compared with the control group induced by IL-6, EGCG and AG490(a Stat3 pathway inhibitor) significantly inhibited VEGF expression induced by IL-6 (P<0.01). alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 63-68 interleukin 6 Homo sapiens 48-52 21866460-10 2011 When compared with the control group induced by IL-6, EGCG and AG490(a Stat3 pathway inhibitor) significantly inhibited VEGF expression induced by IL-6 (P<0.01). alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 63-68 interleukin 6 Homo sapiens 147-151 9378738-10 1997 In contrast, the fluoroquinolone antibiotic ciprofloxacin, which is also a phosphodiesterase inhibitor, caused a dose-dependent inhibition of the synthesis of both tumor necrosis factor-alpha and interleukin-6 by titanium-stimulated monocytes, suggesting that ciprofloxacin suppresses the synthesis of interleukin-6 through a mechanism that is independent of cAMP. Ciprofloxacin 260-273 interleukin 6 Homo sapiens 196-209 9112403-4 1997 TSH-stimulated cultured human thyroid cells exposed for 72 h to IL-1beta (0.0002-20 microg/liter = 1-105 IU/liter) exhibited a dose-dependent and reversible inhibition of thyroglobulin and cAMP release and a dose-dependent stimulation of cGMP and IL-6 release. Thyrotropin 0-3 interleukin 6 Homo sapiens 247-251 21047568-8 2011 Zoledronic acid administration triggered increased serum levels of TNFalpha, IFNgamma, IL-6 and CRP in >=70% of study volunteers, whilst characteristic APR symptoms were observed in >50% of participants. Zoledronic Acid 0-15 interleukin 6 Homo sapiens 87-91 19321592-7 2009 Preincubation with fisetin and tricetin strongly attenuated LPS-induced increases in concentrations of TNFalpha in blood from COPD patients [mean (+/- SEM): -41 +/- 4% (fisetin) and -31 +/- 4% (tricetin); P < 0.001] and IL-6 in blood from T2D patients [-31 +/- 5% (fisetin) and -29 +/- 6% (tricetin); P < or = 0.001]. tricetin 31-39 interleukin 6 Homo sapiens 223-227 19288024-10 2009 Moreover, the severity of sleep-disordered breathing (measured by apnea hypopnea index) increased linearly in carriers of the C variant of IL-6 -572G/C polymorphism (14.3+/-5.1, 22.0+/-3.6 and 34.8+/-3.5 for GG, CG and CC, respectively; p=0.012). cysteinylglycine 212-214 interleukin 6 Homo sapiens 139-143 9129099-3 1997 Imipenem and meropenem induced faster killing of E. coli than ceftriaxone at 2 and 6 h. However, imipenem-induced bacterial killing resulted in significantly less IL-6 release compared with meropenem or ceftriaxone. Imipenem 97-105 interleukin 6 Homo sapiens 163-167 19220017-4 2009 We describe herein the synthesis and biological activity of a series of imidazoline-based scaffolds as potent inhibitors of NF-kappaB mediated gene transcription in cell culture as well as inhibitors of TNF-alpha and IL-6 production in interleukin 1 beta (IL-1beta) stimulated human blood. Imidazolines 72-83 interleukin 6 Homo sapiens 217-221 21098014-10 2011 Baseline D/P Cr was correlated with density of CD68-positive macrophages (P < 0.001), IL-6-positive cells (P < 0.001), CD31-positive (P < 0.05) and PAL-E-positive blood vessels (P < 0.05) and serum albumin (P < 0.05). Chromium 13-15 interleukin 6 Homo sapiens 89-93 21640879-10 2011 The interleukin-6 concentration in the GCF at Tb was a significant predictive value for the GCF flow at T52 (P <0.05). Terbium 46-48 interleukin 6 Homo sapiens 4-17 19248247-3 2009 Results demonstrated that pretreatment with dFMGEN decreased the adhesion between vascular endothelial cells and monocytes, reduced the release of E-Selectin, ICAM-1, IL-6 and TNF-alpha in vascular endothelial cells, and down-regulated the expression of NF-kappaB. 7-difluoromethyl-5,4'-dimethoxygenistein 44-50 interleukin 6 Homo sapiens 167-171 9129099-6 1997 Imipenem, which has a greater affinity for penicillin-binding protein (PBP) 2, induced less IL-6 release from blood and endothelial cells than did PBP 3-specific ceftriaxone and meropenem. Imipenem 0-8 interleukin 6 Homo sapiens 92-96 21756812-13 2011 The levels of IL-6 and MDA were significantly lower at T(1)-T(4) in milrinone group. Milrinone 68-77 interleukin 6 Homo sapiens 14-18 18654091-7 2009 Treatment with LQGV, AQGV, or LAGV prevented systemic release of TNF-[alpha] and IL-6 and was associated with reduced TNF-[alpha], IL-6, and E-selectin mRNA transcript levels in the liver. lagv 30-34 interleukin 6 Homo sapiens 81-85 9134225-13 1997 One of the following cytokines (epidermal growth factor, transforming growth factor alpha, interleukin-1 alpha, interleukin-1 beta, interleukin-6, interleukin-8) was required for 1,25(OH)2D3 to suppress clonal growth and induce cell differentiation. 25(oh)2d3 181-190 interleukin 6 Homo sapiens 132-145 18654091-7 2009 Treatment with LQGV, AQGV, or LAGV prevented systemic release of TNF-[alpha] and IL-6 and was associated with reduced TNF-[alpha], IL-6, and E-selectin mRNA transcript levels in the liver. lagv 30-34 interleukin 6 Homo sapiens 131-135 19101624-5 2009 In the present study, using dendritic cells derived from CD34(+) cord blood cells, we showed that both NiSO(4) and CoCl(2) induced the expression of CD86, CD83, HLA-DR and CD40 and the production of IL-6 in human DCs while K(2)Cr(2)O(7) induced only a slight upregulation of CD86. nickel sulfate 103-110 interleukin 6 Homo sapiens 199-203 21866484-8 2011 In vitro and in vivo experiments show that antiepileptic drugs could affect cytokine levels (e.g. valproate significantly inhibited production of TNF- alpha and IL-6 by human monocytic leukaemia cells). Valproic Acid 98-107 interleukin 6 Homo sapiens 161-165 20158569-9 2011 Simvastatin, atorvastatin, fluvastatin or pravastatin reduced the IL-6 production by 53%, 50%, 64% and 60%, respectively. Pravastatin 42-53 interleukin 6 Homo sapiens 66-70 20158569-11 2011 Combination of statins with aspirin and/or Indo resulted in complete inhibition of the synergistic IL-6 production. Indomethacin 43-47 interleukin 6 Homo sapiens 99-103 9119864-5 1997 In addition, TiAlV stimulated significantly more release of the other cell mediators, interleukin-1, tumour necrosis factor and interleukin-6. tialv 13-18 interleukin 6 Homo sapiens 128-141 21303433-7 2011 In the TBX(17.5%) model, jejunal muscle contractility was suppressed and a systemic inflammatory response developed as significant serum elevations in IL-6, keratinocyte cytokine and IL-10 compared to sham. PEMIROLAST POTASSIUM 7-10 interleukin 6 Homo sapiens 151-155 19179025-8 2009 Serum IL-6 concentration in women treated with paroxetine decreased significantly. Paroxetine 47-57 interleukin 6 Homo sapiens 6-10 19179025-11 2009 CONCLUSION: Decrease in IL-6 concentration may be involved in the mechanism of the actions of both paroxetine and kamishoyosan in women with psychological symptoms, and IL-6 may therefore be useful as a marker of treatment. Paroxetine 99-109 interleukin 6 Homo sapiens 24-28 9062617-7 1997 RESULTS: Serum interleukin-6 values were significantly greater at 6 and 12 h (P < 0.05) in those patients who received etomidate. Etomidate 122-131 interleukin 6 Homo sapiens 15-28 18443862-8 2009 For the mucosal IL-6 level, both the open and air groups were significantly higher than the CO(2) group. Carbon Dioxide 92-97 interleukin 6 Homo sapiens 16-20 21448308-9 2011 However, IL-6 and CRP were significantly lower in flurbiprofen group than in control group at the same day (p < 0.05). Flurbiprofen 50-62 interleukin 6 Homo sapiens 9-13 21448308-12 2011 CONCLUSIONS: Patients undergoing thoracotomy showed reduced postoperative pain, mean additional analgesic consumption, and serum IL-6 and CRP levels, when flurbiprofen was added to systemic analgesic therapy. Flurbiprofen 155-167 interleukin 6 Homo sapiens 129-133 21183183-6 2011 Multivariate linear regression analysis indicated that CKD stage (p=0.04), IL-6 (p=0.02) and albumin (p=0.02) were independently associated with plasma cTN-C levels. ctn-c 152-157 interleukin 6 Homo sapiens 75-79 18996370-4 2009 Microarray analysis using a tetracycline-inducible LMX1B expression system in HeLa cells revealed that a subset of NF-kappaB target genes, including IL-6 and IL-8, are upregulated in LMX1B-expressing cells. Tetracycline 28-40 interleukin 6 Homo sapiens 149-153 19278477-0 2008 Changes of aqueous vascular endothelial growth factor and interleukin-6 after intravitreal triamcinolone for branch retinal vein occlusion. Triamcinolone 91-104 interleukin 6 Homo sapiens 58-71 9041915-11 1997 The responses of IL-6 and IL-1 beta in group 1 were striking compared with those in group 2, and they were accompanied by an elevation of the endotoxin concentration and a subsequent elevation of the concentrations of hepatocyte growth factor, hyaluronic acid, lactate, and other factors that reflected graft viability. Hyaluronic Acid 244-259 interleukin 6 Homo sapiens 17-21 19017992-5 2008 This suggested a role for these TLRs in production of TNF and IL-6 from RA which was supported by data from chloroquine, an inhibitor of endosomal acidification (a prerequisite for TLRs 3, 7, 8, and 9 activation) which also inhibited production of these cytokines from RA synovial cultures. Chloroquine 108-119 interleukin 6 Homo sapiens 62-66 20932155-6 2011 Decrease in IL-6 in the SDD group was significantly higher compared to the placebo group at 6 and 9 months in deep pockets (P <0.05), whereas tumor necrosis factor-alpha was significantly reduced in moderately deep pockets (P <0.05). 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt 24-27 interleukin 6 Homo sapiens 12-16 8943271-4 1996 A construct (HSFDT385SH) of the heat shock transcription factor (HSF) was expressed that contains the DNA-binding and trimerization domains, residues 192-385 of HSF, with four additional COOH-terminal residues, GMLC, and then labeled at the COOH-terminal cysteine with fluorescein 5-maleimide to form HSFDT385-Fl. fluorescein 5-maleimide 269-292 interleukin 6 Homo sapiens 32-63 8943271-4 1996 A construct (HSFDT385SH) of the heat shock transcription factor (HSF) was expressed that contains the DNA-binding and trimerization domains, residues 192-385 of HSF, with four additional COOH-terminal residues, GMLC, and then labeled at the COOH-terminal cysteine with fluorescein 5-maleimide to form HSFDT385-Fl. fluorescein 5-maleimide 269-292 interleukin 6 Homo sapiens 65-68 21372495-6 2011 RESULTS: In ex vivo cultures, raloxifene therapy inhibited LPS-stimulated production of IL-1beta, IL-6, IL-12p40, IL-12p70 and TNF-alpha, but not PHA-stimulated production of IL-4 and IFN-gamma. Raloxifene Hydrochloride 30-40 interleukin 6 Homo sapiens 98-102 21372495-7 2011 In in vitro cultures, raloxifene at a concentration (10(-9) M) inhibited LPS-stimulated production of IL-1beta, IL-6 and IL-12p40 and PHA-stimulated production of IFN-gamma. Raloxifene Hydrochloride 22-32 interleukin 6 Homo sapiens 112-116 19107369-6 2008 The IL-6 level in GG+CG group was significantly higher than that in CC group. cysteinylglycine 21-23 interleukin 6 Homo sapiens 4-8 8884530-4 1996 FK506 and CsA inhibit keratinocyte proliferation induced by EGF, TGF-alpha or IL-6. Tacrolimus 0-5 interleukin 6 Homo sapiens 78-82 18657656-2 2008 BACKGROUND: Interleukin-6 (IL-6) and tissue factor (TF) are elevated after myocardial ischemia during dobutamine stress echo (DSE). nabam 126-129 interleukin 6 Homo sapiens 12-25 18657656-2 2008 BACKGROUND: Interleukin-6 (IL-6) and tissue factor (TF) are elevated after myocardial ischemia during dobutamine stress echo (DSE). nabam 126-129 interleukin 6 Homo sapiens 27-31 21372495-8 2011 CONCLUSIONS: Raloxifene therapy decreases the production of IL-1beta, IL-6, IL-12 and TNF-alpha but not that of IL-4 and IFN-gamma, suggesting that modulation of cytokines could play a role in the mechanisms of the osteoprotective effect of raloxifene. Raloxifene Hydrochloride 13-23 interleukin 6 Homo sapiens 70-74 8884530-6 1996 These findings might indicate that the effects of FK506 and CsA on proliferation of cultured normal human keratinocytes are probably related to direct effects on growth regulation of keratinocytes via EGF, TGF-alpha or IL-6 stimulation. Tacrolimus 50-55 interleukin 6 Homo sapiens 219-223 21280192-7 2011 TUDCA treatment decreased nuclear factor kappa B activation and the proinflammatory cytokines interleukin-6 and interleukin-1beta. ursodoxicoltaurine 0-5 interleukin 6 Homo sapiens 94-107 20157364-8 2008 Pravastatin treatment did not affect LPS-stimulated MCP-1 but increased IL-6 modestly. Pravastatin 0-11 interleukin 6 Homo sapiens 72-76 20157364-10 2008 CRP-stimulated production of IL-6, but not MCP-1, was modestly attenuated by short-term treatment with pravastatin. Pravastatin 103-114 interleukin 6 Homo sapiens 29-33 8888069-7 1996 Continuous infusion of aminophylline resulted in elevations of serum macrophage-CSF and interleukin 6. Aminophylline 23-36 interleukin 6 Homo sapiens 88-101 19026125-1 2008 OBJECTIVE: To assess the association of polymorphisms of the IL-6 receptor gene (+24013A/G:Ala31Ala; +48892 A/C:Asp358Ala), the IL-8 receptor gene (+2607G/C:Ser/Thr IL-8RA), and TNF-alpha 238 (G/A) single nucleotide polymorphism (SNP) with Behcet"s disease in patients of German or Turkish origin. ala31ala 91-99 interleukin 6 Homo sapiens 61-65 21194184-0 2011 A multiple-dose pharmacokinetics of polyethylene glycol recombinant human interleukin-6 (PEG-rhIL-6) in rats. peg-rhil-6 89-99 interleukin 6 Homo sapiens 74-87 9816314-9 1996 Therefore, it seems that the early detection of endogenous IL-6 may represent valuable information for monitoring the response to biochemotherapy in patients with MMM. mmm 163-166 interleukin 6 Homo sapiens 59-63 20849904-6 2010 In controls, LL-37 levels inversely correlated with tumor necrosis factor (TNF)-alpha, IL-6, IL-1beta, and IL-22 levels. Cathelicidin 13-18 interleukin 6 Homo sapiens 87-91 20849904-8 2010 LL-37 enhanced IFN-gamma, IL-4, IL-13, and TNF-alpha secretion from CD3/CD28-stimulated T cells, suppressed TNF-alpha, IL-1beta, IL-6, and IL-10 secretion from lipopolysaccharide-stimulated monocytes, and IL-17, IL-22, IL-1beta, IL-6, and IL-10 secretion from CD3/CD28-stimulated T cells. Cathelicidin 0-5 interleukin 6 Homo sapiens 129-133 20849904-8 2010 LL-37 enhanced IFN-gamma, IL-4, IL-13, and TNF-alpha secretion from CD3/CD28-stimulated T cells, suppressed TNF-alpha, IL-1beta, IL-6, and IL-10 secretion from lipopolysaccharide-stimulated monocytes, and IL-17, IL-22, IL-1beta, IL-6, and IL-10 secretion from CD3/CD28-stimulated T cells. Cathelicidin 0-5 interleukin 6 Homo sapiens 229-233 18081851-5 2008 Furthermore, we show that the Mnk inhibitor CGP57380 is capable of inhibiting the phosphorylation of eIF4E in keratinocytes, and that the abolishment of eIF4E phosphorylation dramatically decreases the anisomycin-induced protein release of the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), IL-1beta and IL-6 as well as the IL-1beta-induced protein release of TNF-alpha. CGP 57380 44-52 interleukin 6 Homo sapiens 325-329 8666820-9 1996 They were, however, at least partially charge mediated, since heparin abolished the effects of MBP on IL-1-stimulated cells, and the surrogate cationic molecule poly-L-arginine mimicked the stimulatory effects of MBP on fibroblast IL-6-type cytokine elaboration. polyarginine 161-176 interleukin 6 Homo sapiens 231-235 18601766-0 2008 Zoledronic acid effects interleukin-6 expression in hormone-independent prostate cancer cell lines. Zoledronic Acid 0-15 interleukin 6 Homo sapiens 24-37 18601766-1 2008 OBJECTIVE: To investigate the inhibitory effects of zoledronic acid (ZA) on tumor related growth factor IL-6 in hormone resistant prostate cancer cell lines. Zoledronic Acid 52-67 interleukin 6 Homo sapiens 104-108 18601766-1 2008 OBJECTIVE: To investigate the inhibitory effects of zoledronic acid (ZA) on tumor related growth factor IL-6 in hormone resistant prostate cancer cell lines. Zoledronic Acid 69-71 interleukin 6 Homo sapiens 104-108 17852073-6 2008 Plasma beta-carotene inversely correlated with IL-6 (r = -0.46, p=0.0002) and CRP (r = -0.41, p = 0.001). beta Carotene 7-20 interleukin 6 Homo sapiens 47-51 21792817-5 2010 Beta-carotene significantly inversely correlated with interleukin-6. beta Carotene 0-13 interleukin 6 Homo sapiens 54-67 20881945-6 2010 CTQ total scores were positively correlated with overall change in IL-6 response, as well as the maximum IL-6 concentration during the TSST. cysteine tryptophylquinone 0-3 interleukin 6 Homo sapiens 67-71 20881945-6 2010 CTQ total scores were positively correlated with overall change in IL-6 response, as well as the maximum IL-6 concentration during the TSST. cysteine tryptophylquinone 0-3 interleukin 6 Homo sapiens 105-109 8838671-9 1996 Fibroblasts responded to the addition of dermatan sulfate, heparan sulfate and heparin with a decrease in fibronectin, collagenase and interleukin-6 mRNA. Heparitin Sulfate 59-74 interleukin 6 Homo sapiens 135-148 20095806-0 2010 Long-term effect of high doses glucocorticosteroids on mRNA expression for IL-6 and IL-8 in relapsed multiple sclerosis patients. glucocorticosteroids 31-51 interleukin 6 Homo sapiens 75-79 18543066-7 2008 BC colonization provokes a strong osteoblast inflammatory response marked by increased expression of the pro-inflammatory cytokine IL-6. biochar 0-2 interleukin 6 Homo sapiens 131-135 8592085-3 1996 Transcription of IL-6 mRNA was first detectable 2 h after stimulation with the ester phorbol myristate acetate (PMA) and the calcium ionophore A23187 in both cell lines, as evidenced by semiquantitative reverse transcriptase polymerase chain reaction analysis. Calcimycin 143-149 interleukin 6 Homo sapiens 17-21 8597883-1 1995 We performed an open, between patients, placebo controlled study in order to evaluate the effect of the treatment with the non steroidal anti inflammatory drugs indomethacin, diclofenac and naproxen on the concentrations of the cytokines IL-1 beta and IL-6 and of the neuropeptide substance P in plasma and synovial fluid of 24 rheumatoid arthritis patients. Diclofenac 175-185 interleukin 6 Homo sapiens 252-256 18209570-9 2008 The cardioprotective effects of pravastatin were closely associated with the downregulation of collagen I, transforming growth factor-beta, matrix metalloproteinases-2 and -3, atrial natriuretic factor, interleukin-6, tumor necrosis factor-alpha, ROCK1 gene expression, and the upregulation of endothelial nitric oxide synthase gene expression. Pravastatin 32-43 interleukin 6 Homo sapiens 203-245 20471468-6 2010 In an in vitro cellular model with RAW 264.7 macrophages, GdCl(3) increased the production of TGF-beta1 and IL-6 via the activation of PKC and ERK signaling pathway. gdcl 58-62 interleukin 6 Homo sapiens 108-112 20600219-4 2010 Synergistic release of IL-6 by MALP-2 and NiSO4 was obvious after 8h of co-stimulation and correlated with a late phase accumulation of IL-6 mRNA. nickel sulfate 42-47 interleukin 6 Homo sapiens 23-27 7579410-5 1995 XG1 cells strongly upregulate IL-6 production by MG63 and Saos-2 cells. mg63 49-53 interleukin 6 Homo sapiens 30-34 20600219-4 2010 Synergistic release of IL-6 by MALP-2 and NiSO4 was obvious after 8h of co-stimulation and correlated with a late phase accumulation of IL-6 mRNA. nickel sulfate 42-47 interleukin 6 Homo sapiens 136-140 21328888-1 2010 The paper presents the results of studying the effect of 10% perfluorane (PF) emulsion intravenously injected 1-2 days before surgical treatment for rhegmatogenous retinal detachment on the levels of the cytokines IL-1beta, TNF-alpha, IL-6, and IL-4 in the serum and subretinal fluid of patients. pf 74-76 interleukin 6 Homo sapiens 235-239 21328888-2 2010 PF infusion was found to exert an immunomodulatory effect that favored a short-term increase in the serum level of proinflammatory cytokines (IL- 1beta and IL-6) at week 1 and TNF-alpha on day 1) with their gradual normalization. pf 0-2 interleukin 6 Homo sapiens 156-160 18488162-10 2008 Proinflammatory cytokines such as TNF-alpha and IL-6 may also play a role in pathogenesis of zoledronic acid-related uveitis. Zoledronic Acid 93-108 interleukin 6 Homo sapiens 48-52 18045952-8 2007 In order to understand implications of SOCS-3 regulation by androgen, we used SOCS-3-negative LNCaP-IL-6 cells and stably transfected them with a tetracycline-responsive SOCS-3 Tet-On plasmid. Tetracycline 146-158 interleukin 6 Homo sapiens 100-104 7543732-5 1995 Apigenin also inhibited IL-1 alpha-induced prostaglandin synthesis and TNF-alpha-induced IL-6 and IL-8 production, suggesting that the hydroxyflavones may act as general inhibitors of cytokine-induced gene expression. hydroxyflavones 135-150 interleukin 6 Homo sapiens 89-93 18075971-4 2007 We have investigated whether spironolactone has direct effects on glucose uptake and interleukin-6 secretion in human adipocytes. Spironolactone 29-43 interleukin 6 Homo sapiens 85-98 18075971-7 2007 Spironolactone, but not canrenoic acid, significantly reduced basal interleukin-6 secretion by cultured stromal-vascular cells. Spironolactone 0-14 interleukin 6 Homo sapiens 68-81 21351565-0 2010 [Effect of ginkgolide B on the production of NO, IL-6 and RANTES from astrocytes]. ginkgolide B 11-23 interleukin 6 Homo sapiens 49-53 21351565-1 2010 This study is to explore the effect of ginkgolide B (BN52021) on the production of nitric oxide (NO), interleukin (IL)-6 and regulated upon activation normal T cell expressed and secreted (RANTES) from astrocytes induced by stimulators. ginkgolide B 39-51 interleukin 6 Homo sapiens 102-120 21351565-7 2010 Ginkgolide B at concentrations of 0.1-10 micromol L(-1) were shown to inhibit RANTES secretion, and to inhibit mRNA expression of IL-6 and RANTES at concentration of 10 micromol L(-1). ginkgolide B 0-12 interleukin 6 Homo sapiens 130-134 8556063-7 1995 On the second day of IFN treatment, simultaneous administration of 25 mg diclofenac sodium eliminated the IFN effects on circulating ACTH, cortisol and IL-6 concentrations. Diclofenac 73-90 interleukin 6 Homo sapiens 152-156 21351565-8 2010 Ginkgolide B has inhibitory effect on the production of NO, IL-6 and RANTES from astrocytes treated with inflammatory stimulators. ginkgolide B 0-12 interleukin 6 Homo sapiens 60-64 20463041-7 2010 RESULTS: A 1-g increment in habitual dietary ALA intake was associated with 11.0% lower concentrations of sIL-6R (P = 0.004) but not of IL-6 (P = 0.31), TNF-alpha (P = 0.16), or hsCRP (P = 0.36) after adjustment for energy intake, nutritional factors, known cardiovascular disease risk factors, and medications. alpha-Linolenic Acid 45-48 interleukin 6 Homo sapiens 107-111 20463041-8 2010 After further control for shared genetic and common environmental factors by comparison of brothers within a twin pair, a twin with a 1-g higher ALA intake was likely to have 10.9% (95% CI: 3.7%, 17.6%; P = 0.004) lower sIL-6R concentrations than his co-twin with a low intake, whereas ALA intake was not significantly associated with plasma concentrations of IL-6, TNF-alpha, or hsCRP. alpha-Linolenic Acid 145-148 interleukin 6 Homo sapiens 221-225 17947694-6 2007 We evidenced that EPs down-regulated both at the mRNA and protein levels the proinflammatory TNF-alpha, IL-1beta, and IL-6 expression in LPS-activated monocytes. eps 18-21 interleukin 6 Homo sapiens 118-122 17537833-7 2007 In addition, pretreatment with IL-6 altered the cellular responsiveness in an opposite manner of overexpression of HCE1 and HCE2 toward various ester therapeutic agents (e.g., clopidogrel). Esters 144-149 interleukin 6 Homo sapiens 31-35 7549842-0 1995 Dexamethasone and suramin inhibit cell proliferation and interleukin-6-mediated immunoglobulin secretion in human lymphoid and multiple myeloma cell lines. Suramin 18-25 interleukin 6 Homo sapiens 57-70 7549842-5 1995 This study examines growth inhibition and inhibition of IL-6-mediated secretion of immunoglobulin in human lymphoid and myeloma cell lines by dexamethasone and suramin. Suramin 160-167 interleukin 6 Homo sapiens 56-60 17512458-6 2007 Treatment of placenta and fetal membranes with 15-A(2)-IsoP caused a dose-dependent decrease in LPS-stimulated release of the cytokines IL-1beta, IL-6, IL-8, and TNF-alpha and the prostaglandins PGE(2) and PGF(2)alpha. 15-a(2)-isop 47-59 interleukin 6 Homo sapiens 146-150 16860297-7 2007 Exposure to the photochemically generated products of BD (primarily acrolein, acetaldehyde, formaldehyde, furan and ozone) induced significant increases in cytotoxicity, IL-8, and IL-6 gene expression compared to a synthetic mixture of primary products that was created by injecting the correct concentrations of the detected products from the irradiation experiments. Acetaldehyde 78-90 interleukin 6 Homo sapiens 180-184 20557833-8 2010 The addition of linezolid significantly reduced mRNA levels of IL-1beta, IL-6, IL-8 and TNF-alpha; (p < 0.05) after 2 and 4 h. LPS stimulation also increased levels of IL-6, IL-8 and TNF-alpha between 100 and 1000-fold. Linezolid 16-25 interleukin 6 Homo sapiens 73-77 20557833-8 2010 The addition of linezolid significantly reduced mRNA levels of IL-1beta, IL-6, IL-8 and TNF-alpha; (p < 0.05) after 2 and 4 h. LPS stimulation also increased levels of IL-6, IL-8 and TNF-alpha between 100 and 1000-fold. Linezolid 16-25 interleukin 6 Homo sapiens 171-175 7549842-7 1995 IL-6-mediated immunoglobulin secretion is also inhibited by both dexamethasone and suramin in an additive fashion. Suramin 83-90 interleukin 6 Homo sapiens 0-4 17284733-10 2007 CONCLUSIONS: Increased intakes of dietary ALA elicit antiinflammatory effects by inhibiting IL-6, IL-1beta, and TNF-alpha production in cultured PBMCs. alpha-Linolenic Acid 42-45 interleukin 6 Homo sapiens 92-96 7549842-8 1995 Both dexamethasone and suramin induce apoptosis of lymphoid cell lines, and suramin inhibits the binding of IL-6 to its receptor in a multiple myeloma cell line. Suramin 76-83 interleukin 6 Homo sapiens 108-112 7549842-9 1995 These findings suggest that the synergistic growth inhibitory activities of dexamethasone and suramin may be related to induction of apoptosis by both agents and inhibition of IL-6-mediated autocrine growth stimulation and immunoglobulin production. Suramin 94-101 interleukin 6 Homo sapiens 176-180 17374489-3 2006 This prospective study investigated the association between serum and urine IL-6 and IL-8 levels and acute pyelonephritis confirmed by (99m)Tc-dimercaptosuccinic acid (DMSA) scan. tc-dimercaptosuccinic acid 140-166 interleukin 6 Homo sapiens 76-80 20407805-6 2010 The increasing of hematological values by bLf is related to the decrease of serum IL-6 and the increase of serum hepcidin, detected as prohepcidin, whereas ferrous sulfate increases IL-6 and fails to increase hematological parameters and prohepcidin. ferrous sulfate 156-171 interleukin 6 Homo sapiens 182-186 7704910-5 1995 A cAMP analog (dibutyryl cAMP), a stimulator of adenyl cyclase (forskolin), and phosphodiesterase inhibitors (aminophylline and IBMX) which inhibited the 446-BCDF-induced decrease in intracellular cAMP, inhibited 446-BCDF-induced B cell differentiation, suggesting that the fall in intracellular cAMP was a critical event in this process. Aminophylline 110-123 interleukin 6 Homo sapiens 158-162 7704910-5 1995 A cAMP analog (dibutyryl cAMP), a stimulator of adenyl cyclase (forskolin), and phosphodiesterase inhibitors (aminophylline and IBMX) which inhibited the 446-BCDF-induced decrease in intracellular cAMP, inhibited 446-BCDF-induced B cell differentiation, suggesting that the fall in intracellular cAMP was a critical event in this process. Aminophylline 110-123 interleukin 6 Homo sapiens 217-221 20445007-7 2010 PAM stimulation also induced IL-1beta, IL-6, and IL-8. pam 0-3 interleukin 6 Homo sapiens 39-43 17050345-7 2006 Significant inductions of IL-1beta, TNF-alpha, and Cox-1 and Cox-2 mRNA were observed following exposure to > or =50 ppm acetaldehyde for 4 h. IL-6 and MCP-1 were also induced following a 4-h exposure to 500 ppm acetaldehyde. Acetaldehyde 124-136 interleukin 6 Homo sapiens 146-150 17050345-7 2006 Significant inductions of IL-1beta, TNF-alpha, and Cox-1 and Cox-2 mRNA were observed following exposure to > or =50 ppm acetaldehyde for 4 h. IL-6 and MCP-1 were also induced following a 4-h exposure to 500 ppm acetaldehyde. Acetaldehyde 215-227 interleukin 6 Homo sapiens 146-150 20445007-10 2010 In contrast, delayed DEX addition significantly suppressed PAM-induced IL-1beta, IL-6, or IL-8 and also suppressed LPS-induced IL-1beta and IL-8. pam 59-62 interleukin 6 Homo sapiens 81-85 7654630-4 1995 Monocytes/macrophages incubated on PDMS, silicone rubber and low density polyethylene, LDPE, with or without protein adsorption produced variable levels of IL-1 beta, IL-6 and TNF-alpha dependent on the polymer and adsorbed protein. Polyethylene 73-85 interleukin 6 Homo sapiens 167-171 20219762-0 2010 Associations of toenail selenium levels with inflammatory biomarkers of fibrinogen, high-sensitivity c-reactive protein, and interleukin-6: The CARDIA Trace Element Study. Selenium 24-32 interleukin 6 Homo sapiens 125-138 20646353-10 2010 Ferrous sulfate increased IL-6 (P less than 0.0001) and decreased prohepcidin (P=0.093). ferrous sulfate 0-15 interleukin 6 Homo sapiens 26-30 16793192-7 2006 Promutoxin is also able to stimulate the release of IL-12, TNFalpha, IL-6 and IL-1beta from human monocytes, and induce IL-2, TNFalpha and IL-6 release from T cells, indicating that this snake venom group IIA PLA(2) is actively involved in the inflammatory process in man caused by snake venom poisoning. promutoxin 0-10 interleukin 6 Homo sapiens 69-73 16793192-7 2006 Promutoxin is also able to stimulate the release of IL-12, TNFalpha, IL-6 and IL-1beta from human monocytes, and induce IL-2, TNFalpha and IL-6 release from T cells, indicating that this snake venom group IIA PLA(2) is actively involved in the inflammatory process in man caused by snake venom poisoning. promutoxin 0-10 interleukin 6 Homo sapiens 139-143 16806458-3 2006 Results indicate that a number of the primary carbon/resin materials demonstrate efficient adsorption of the cytokines studied here (TNF, IL-6 and IL-8), comparable to other adsorbents under clinical investigation. Resins, Plant 53-58 interleukin 6 Homo sapiens 138-142 7881384-2 1994 At confluency of HSF cultures, hyaluronan increased the level of HSFEp in a time and dose-dependent fashion. Hyaluronic Acid 31-41 interleukin 6 Homo sapiens 17-20 17122961-6 2006 The PKC inhibitor, GF1090203X, blocked the histamine stimulated IL-6 release. gf1090203x 19-29 interleukin 6 Homo sapiens 64-68 20199352-2 2010 We have investigated if IL-6 and IL-18 levels were related to coenzyme Q(10) (CoQ(10)), an antioxidant and a marker of oxidative stress in the plasma from normotensive and preeclamptic pregnancies. coq 78-81 interleukin 6 Homo sapiens 24-28 7528280-0 1994 FK506, an immunosuppressant, partially inhibits interleukin 6 production by adherent rheumatoid synovial cells. Tacrolimus 0-5 interleukin 6 Homo sapiens 48-61 20044439-0 2010 LPA induces IL-6 secretion from aortic smooth muscle cells via an LPA1-regulated, PKC-dependent, and p38alpha-mediated pathway. lysophosphatidic acid 0-3 interleukin 6 Homo sapiens 12-16 20044439-3 2010 To profile LPA-induced cytokine production in vascular smooth muscle cells (SMCs), we used a cytokine antibody array system and found that LPA prominently induces the secretion of IL-6 and monocyte chemoattractant protein (MCP)-1 from human aortic SMCs (HASMCs). lysophosphatidic acid 11-14 interleukin 6 Homo sapiens 180-184 20044439-6 2010 The present study reveals that LPA induces the expression of IL-6 mRNA and protein in HASMCs as well as the secretion of IL-6 protein in a time-dependent manner. lysophosphatidic acid 31-34 interleukin 6 Homo sapiens 61-65 16814517-4 2006 Ethyl pyruvate also decreases cyclo-oxygenase-2, inducible nitric oxide synthase, and interleukin-6 mRNA expression in the liver, ileal mucosa, and colonic mucosa in animal models with hemorrhagic shock. ethyl pyruvate 0-14 interleukin 6 Homo sapiens 86-99 16820996-8 2006 hs-IL-6 concentrations were statistically significantly associated with peroxy radicals and CRP levels (respectively: P<0.05, r2=0.1; P<0.05, r2=0.14). peroxy radicals 72-87 interleukin 6 Homo sapiens 3-7 20044439-6 2010 The present study reveals that LPA induces the expression of IL-6 mRNA and protein in HASMCs as well as the secretion of IL-6 protein in a time-dependent manner. lysophosphatidic acid 31-34 interleukin 6 Homo sapiens 121-125 20044439-7 2010 Our results demonstrate that LPA-specific receptor 1 (LPA(1)) mediates LPA-induced IL-6 secretion and that LPA induction of IL-6 is independent of the EGF receptor pathway. lysophosphatidic acid 29-32 interleukin 6 Homo sapiens 83-87 20044439-7 2010 Our results demonstrate that LPA-specific receptor 1 (LPA(1)) mediates LPA-induced IL-6 secretion and that LPA induction of IL-6 is independent of the EGF receptor pathway. lysophosphatidic acid 54-57 interleukin 6 Homo sapiens 83-87 20044439-9 2010 Finally, small interfering RNA depletion experiments revealed that p38alpha is specifically responsible for the LPA-induced IL-6 secretion. lysophosphatidic acid 112-115 interleukin 6 Homo sapiens 124-128 16539678-3 2006 We herein report that sulfated polymannuroguluronate (SPMG), a novel anti-acquired immunodeficiency syndrome drug candidate now in a phase II clinical trial, significantly reversed Tat-induced release of pro-inflammatory cytokines [tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta) and IL-6] and dose dependently decreased the accumulation of reactive oxygen species and nitric oxide in THP-1 cells. sulfated polymannuroguluronate 54-58 interleukin 6 Homo sapiens 296-300 20044439-10 2010 The present study profiles the regulatory relationship between LPA and multiple cytokines in vascular SMCs for the first time, provides the first evidence that LPA upregulates IL-6 in vascular SMCs, and reveals the regulatory mechanism of LPA-induced IL-6 production in HASMCs. lysophosphatidic acid 63-66 interleukin 6 Homo sapiens 176-180 7528280-1 1994 OBJECTIVE: To investigate the effect of a new immunosuppressant, FK506, on interleukin 6 (IL-6) production by freshly prepared rheumatoid synovial cells. Tacrolimus 65-70 interleukin 6 Homo sapiens 75-88 20044439-10 2010 The present study profiles the regulatory relationship between LPA and multiple cytokines in vascular SMCs for the first time, provides the first evidence that LPA upregulates IL-6 in vascular SMCs, and reveals the regulatory mechanism of LPA-induced IL-6 production in HASMCs. lysophosphatidic acid 63-66 interleukin 6 Homo sapiens 251-255 20044439-10 2010 The present study profiles the regulatory relationship between LPA and multiple cytokines in vascular SMCs for the first time, provides the first evidence that LPA upregulates IL-6 in vascular SMCs, and reveals the regulatory mechanism of LPA-induced IL-6 production in HASMCs. lysophosphatidic acid 160-163 interleukin 6 Homo sapiens 176-180 7528280-1 1994 OBJECTIVE: To investigate the effect of a new immunosuppressant, FK506, on interleukin 6 (IL-6) production by freshly prepared rheumatoid synovial cells. Tacrolimus 65-70 interleukin 6 Homo sapiens 90-94 20044439-10 2010 The present study profiles the regulatory relationship between LPA and multiple cytokines in vascular SMCs for the first time, provides the first evidence that LPA upregulates IL-6 in vascular SMCs, and reveals the regulatory mechanism of LPA-induced IL-6 production in HASMCs. lysophosphatidic acid 160-163 interleukin 6 Homo sapiens 251-255 20044439-10 2010 The present study profiles the regulatory relationship between LPA and multiple cytokines in vascular SMCs for the first time, provides the first evidence that LPA upregulates IL-6 in vascular SMCs, and reveals the regulatory mechanism of LPA-induced IL-6 production in HASMCs. lysophosphatidic acid 160-163 interleukin 6 Homo sapiens 176-180 16278310-0 2006 Targeting receptor kinases by a novel indolinone derivative in multiple myeloma: abrogation of stroma-derived interleukin-6 secretion and induction of apoptosis in cytogenetically defined subgroups. Oxindoles 38-48 interleukin 6 Homo sapiens 110-123 7528280-7 1994 This spontaneous production of IL-6 was significantly inhibited by FK506 at the concentration of 10(-8) to 10(-6) M in a dose dependent manner. Tacrolimus 67-72 interleukin 6 Homo sapiens 31-35 16393986-9 2006 Thus, PTX-B suppression of IL-6 induced expression of HIV and cellular genes in chronically infected promonocytic cells is strongly correlated to inhibition of AP-1. ptx 6-9 interleukin 6 Homo sapiens 27-31 20044439-10 2010 The present study profiles the regulatory relationship between LPA and multiple cytokines in vascular SMCs for the first time, provides the first evidence that LPA upregulates IL-6 in vascular SMCs, and reveals the regulatory mechanism of LPA-induced IL-6 production in HASMCs. lysophosphatidic acid 160-163 interleukin 6 Homo sapiens 251-255 7528280-8 1994 In the preincubation study, FK506 required more than 12 h to inhibit IL-6 production by synovial cells. Tacrolimus 28-33 interleukin 6 Homo sapiens 69-73 7528280-9 1994 CONCLUSION: These results suggest that FK506 may be beneficial for patients with RA via inhibiting IL-6 production in inflammatory joints. Tacrolimus 39-44 interleukin 6 Homo sapiens 99-103 7800135-6 1994 An antisense phosphorothioate oligonucleotide against IL-6 messenger RNA inhibited both [3H]thymidine uptake and IL-6 secretion by acoustic neuroma cells in culture. Phosphorothioate Oligonucleotides 13-45 interleukin 6 Homo sapiens 54-58 19924017-6 2010 RESULTS: Abdominal insufflation with CO2 before induction of AP caused a significant decrease in ascites volume, cells, and TNF-alpha in the peritoneal cavity and in serum TNF-alpha and IL-6 but not IL-10 levels. Carbon Dioxide 37-40 interleukin 6 Homo sapiens 186-190 16475708-6 2006 Our data showed that primarily IGF-1, TGF beta 1 and IL-6 (up to 25 ng/ml for 48 h) increased PTHrP mRNA expression and modified its perinuclear localization, while zoledronic acid (up to 100 microM for 48 h) inhibited cell proliferation and suppressed PTHrP expression in the MG-63 osteosarcoma cells. Zoledronic Acid 165-180 interleukin 6 Homo sapiens 53-57 7800135-6 1994 An antisense phosphorothioate oligonucleotide against IL-6 messenger RNA inhibited both [3H]thymidine uptake and IL-6 secretion by acoustic neuroma cells in culture. Phosphorothioate Oligonucleotides 13-45 interleukin 6 Homo sapiens 113-117 7811548-5 1994 We have exploited the chimeric fusion toxin DAB389-IL-6, which exerts cellular toxicity only to the cells expressing IL-6R. dab389 44-50 interleukin 6 Homo sapiens 51-55 7811548-7 1994 DAB389-IL-6 inhibited protein synthesis in AIDS-KS-derived spindle cells at very low concentrations (IC50 of 3.4 x 10(-11) M). dab389 0-6 interleukin 6 Homo sapiens 7-11 16169525-4 2005 In addition, LA, ALA, and DHA decreased IL-6, IL-1beta, and TNFalpha gene expression (P < 0.05 for all) and nuclear factor (NF)-kappaB DNA-binding activity, whereas peroxisome proliferator-activated receptor-gamma (PPARgamma) DNA-binding activity was increased. alpha-Linolenic Acid 17-20 interleukin 6 Homo sapiens 40-44 20090836-7 2010 OMV containing MID bound to and activated tonsillar CD19(+) IgD(+) lymphocytes resulting in IL-6 and IgM production in addition to increased surface marker density (HLA-DR, CD45, CD64, and CD86), whereas MID-deficient OMV failed to induce B cell activation. 1-ethylcyclopentyl [(2R,6S,12Z,13aS,14aR,16aS)-2-[(7-methoxy-3-methylquinoxalin-2-yl)oxy]-14a-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl]carbamate 0-3 interleukin 6 Homo sapiens 92-96 7811548-8 1994 Similarly, inhibition of cell viability by DAB389-IL-6 was observed at equivalent dose levels (IC50 of 5 x 10(-11)). dab389 43-49 interleukin 6 Homo sapiens 50-54 7811548-10 1994 Thus, DAB389-IL-6 is a potential agent for the treatment of AIDS-associated KS. dab389 6-12 interleukin 6 Homo sapiens 13-17 15894558-6 2005 Inhibition of STAT3 signaling pathway by either AG-490 (JAK2-specific inhibitor) or overexpression of STAT3Y705F (a dominant-negative STAT3) reverses NSE expression in IL-6- treated NSCLC-NE cells. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 48-54 interleukin 6 Homo sapiens 168-172 7754794-1 1994 It has been reported that lithium salt compounds influence hematopoiesis, which is known to be regulated by a number of cytokines, including tumor necrosis factor (TNF), interleukin-1 (IL-1) and interleukin-6 (IL-6). lithium salt 26-38 interleukin 6 Homo sapiens 195-208 16086584-2 2005 Madindoline A (MadA), isolated from Streptomyces nitrosporeus K93-0711, specifically inhibits the growth of IL-6- and IL-11-dependent cell lines, most likely by interfering with the homodimerization of gp130. madindoline A 0-13 interleukin 6 Homo sapiens 108-112 15836625-12 2005 A selective EP4 receptor antagonist L-161982 was able to suppress IL-6 release, whereas an EP1 receptor antagonist, SC19220, was ineffective. L-161982 36-44 interleukin 6 Homo sapiens 66-70 19466942-9 2009 IL-6 secretion in UPEC-infected A498 cells was decreased by 38% when exposed to the A(2A) receptor agonist CGS 21680. cysteinylglycine 107-110 interleukin 6 Homo sapiens 0-4 19544037-0 2009 Food derived carbonyl compounds affect basal and stimulated secretion of interleukin-6 and -8 in Caco-2 cells. carbonyl compounds 13-31 interleukin 6 Homo sapiens 73-93 7754794-1 1994 It has been reported that lithium salt compounds influence hematopoiesis, which is known to be regulated by a number of cytokines, including tumor necrosis factor (TNF), interleukin-1 (IL-1) and interleukin-6 (IL-6). lithium salt 26-38 interleukin 6 Homo sapiens 210-214 7947242-4 1994 According to previous observations, IL-6 had a stimulatory effect on Epo production by CoCl2-treated Hep3B cells; however, the simultaneous addition of IFN-gamma and IL-6 resulted in a reversal of the stimulatory effects due to IL-6. cobaltous chloride 87-92 interleukin 6 Homo sapiens 36-40 19885628-12 2009 Both AdG and AdFl exert anti-inflammatory activity suppressing IL-6 and MCP-1 production from inflamed adipocytes. Ala-Asp-Gly 5-8 interleukin 6 Homo sapiens 63-67 15701708-7 2005 In addition, AGIX-4207 inhibited cytokine-induced levels of monocyte chemoattractant protein-1, interleukin (IL)-6, and IL-8 from endothelial cells and human fibroblast-like synoviocytes as well as lipopolysaccharide-induced release of TNF-alpha, IL-1beta, and IL-6 from human peripheral blood mononuclear cells. camobucol 13-22 interleukin 6 Homo sapiens 96-114 15701708-7 2005 In addition, AGIX-4207 inhibited cytokine-induced levels of monocyte chemoattractant protein-1, interleukin (IL)-6, and IL-8 from endothelial cells and human fibroblast-like synoviocytes as well as lipopolysaccharide-induced release of TNF-alpha, IL-1beta, and IL-6 from human peripheral blood mononuclear cells. camobucol 13-22 interleukin 6 Homo sapiens 261-265 19009233-6 2009 In addition, trichodimerol blocked IFN-gamma, IL-6 and IL-4 induced activation of Stat1, Stat3 and Stat6 transcription factors by inhibiting serine and tyrosine phosphorylation. trichodimerol 13-26 interleukin 6 Homo sapiens 46-50 7947242-4 1994 According to previous observations, IL-6 had a stimulatory effect on Epo production by CoCl2-treated Hep3B cells; however, the simultaneous addition of IFN-gamma and IL-6 resulted in a reversal of the stimulatory effects due to IL-6. cobaltous chloride 87-92 interleukin 6 Homo sapiens 166-170 19692118-9 2009 Moreover, the coatings synthesized from hydroxyapatite at relatively high bisphosphonate content (7.1% wt) displayed a reduced production of Tumour Necrosis Factor alpha (TNF-alpha) and Interleukin 6 (IL-6), suggesting a down-regulatory role of alendronate on the inflammatory reaction. Durapatite 40-54 interleukin 6 Homo sapiens 186-199 15863947-6 2005 Along with increases in serum catecholamine and urine catecholamine metabolites, his serum interleukin (IL)-6 level was increased to 300 pg/ml, compared with a normal range of 3-12 pg/ml. Catecholamines 30-43 interleukin 6 Homo sapiens 91-109 7947242-4 1994 According to previous observations, IL-6 had a stimulatory effect on Epo production by CoCl2-treated Hep3B cells; however, the simultaneous addition of IFN-gamma and IL-6 resulted in a reversal of the stimulatory effects due to IL-6. cobaltous chloride 87-92 interleukin 6 Homo sapiens 166-170 15863947-6 2005 Along with increases in serum catecholamine and urine catecholamine metabolites, his serum interleukin (IL)-6 level was increased to 300 pg/ml, compared with a normal range of 3-12 pg/ml. Catecholamines 54-67 interleukin 6 Homo sapiens 91-109 19692118-9 2009 Moreover, the coatings synthesized from hydroxyapatite at relatively high bisphosphonate content (7.1% wt) displayed a reduced production of Tumour Necrosis Factor alpha (TNF-alpha) and Interleukin 6 (IL-6), suggesting a down-regulatory role of alendronate on the inflammatory reaction. Durapatite 40-54 interleukin 6 Homo sapiens 201-205 19865006-8 2009 Penetration of morphine metabolites into the central nervous system increased in proportion to the neuroinflammatory response as demonstrated by the positive correlation between cerebrospinal fluid interleukin-6 exposure and the area under the curve cerebrospinal fluid/plasma ratio for morphine-3-glucuronide (r = .49, p < .001) and morphine-6-glucuronide (r = .51, p < .001). morphine-3-glucuronide 287-309 interleukin 6 Homo sapiens 198-211 8263325-3 1994 Within hours after IP administration of liposaccharide, IL-6 mRNA accumulated in the anterior lobe of the pituitary. liposaccharide 40-54 interleukin 6 Homo sapiens 56-60 19671672-7 2009 The growth-inhibiting effects of NAFs were counteracted by the addition of IL-6, and the growth-promoting effects exerted by the CAFs were counteracted by tumor necrosis factor-alpha. Sodium Fluoride 33-37 interleukin 6 Homo sapiens 75-79 18597869-9 2009 AICAR, a direct AMPK activator, had inhibitory effects on TNF-alpha-induced IL-6 production, similar to that of metformin. AICA ribonucleotide 0-5 interleukin 6 Homo sapiens 76-80 15652235-10 2005 PD98059 preferentially inhibited GM-CSF production whereas BAY 11-8702 prevented IL-8 and IL-6 production. bay 11-8702 59-70 interleukin 6 Homo sapiens 90-94 18475583-1 1994 The effect of FK506 and cyclosporin A (CsA) on the production of interleukin 6 (IL-6) in adherent monocytes was studied at a single-cell level by the avidinbiotin- peroxidase complex methods. Tacrolimus 14-19 interleukin 6 Homo sapiens 65-78 15588680-6 2005 The production of IL-6 and IL-8 was dose-dependently inhibited by pretreatment with ZST (0.01-1 mg/ml) on IL-1beta and Abeta-stimulated U373MG cells. UNII-042A8N37WH 119-124 interleukin 6 Homo sapiens 18-22 19321592-8 2009 Moreover, LPS-induced changes in TNFalpha and IL-6 concentrations were positively correlated with the extent of reduction by fisetin and tricetin. tricetin 137-145 interleukin 6 Homo sapiens 46-50 18475583-1 1994 The effect of FK506 and cyclosporin A (CsA) on the production of interleukin 6 (IL-6) in adherent monocytes was studied at a single-cell level by the avidinbiotin- peroxidase complex methods. Tacrolimus 14-19 interleukin 6 Homo sapiens 80-84 18475583-3 1994 Both FK506 and CsA enhanced the percentage of IL-6- producing monocytes stimulated with 100 pg/ml-1 mug/ml of LPS up to values near those obtained with 10 mug/ml of LPS. Tacrolimus 5-10 interleukin 6 Homo sapiens 46-50 19201813-6 2009 In accordance with ozone-induced increases in PGE(2) levels, cyclooxygenase inhibition with indomethacin partially abolished IL-6 secretion. Indomethacin 92-104 interleukin 6 Homo sapiens 125-129 18475583-8 1994 Moreover, pretreatment of monocytes with FK506 and CsA had a significant enhancing effect on LPS-induced IL-6 production, while treatment with FK506 or CsA after LPS stimulation had no effects on IL-6 production, suggesting that the enhancing effect of each drug is exerted before LPS stimulation or at an early stage of the post-receptor pathway after LPS stimulation. Tacrolimus 41-46 interleukin 6 Homo sapiens 105-109 18475583-9 1994 These experiments demonstrate that FK506 and CsA can selectively enhance IL-6 production in monocytes under certain conditions in vitro and, possibly, also in vivo. Tacrolimus 35-40 interleukin 6 Homo sapiens 73-77 7870342-4 1994 In another experiment we observed that the IL-6 production stimulated by serum from patients A could be inhibited by addition of specific monosaccharides. Monosaccharides 138-153 interleukin 6 Homo sapiens 43-47 18953633-7 2009 Although CpG-ODN had no significant effect on the IL-6 production, it was able to induce the increase of TNF-alpha protein expression and this effect was inhibited by CHQ pretreatment. Chloroquine 167-170 interleukin 6 Homo sapiens 50-54 19249598-0 2009 Neodymium-doped yttrium-aluminium-garnet laser irradiation abolishes the increase in interleukin-6 levels caused by peptidoglycan through the p38 mitogen-activated protein kinase pathway in human pulp cells. Neodymium 0-9 interleukin 6 Homo sapiens 85-98 19249598-0 2009 Neodymium-doped yttrium-aluminium-garnet laser irradiation abolishes the increase in interleukin-6 levels caused by peptidoglycan through the p38 mitogen-activated protein kinase pathway in human pulp cells. Aluminum 24-33 interleukin 6 Homo sapiens 85-98 19249598-3 2009 In the present study, to elucidate the mechanism behind the anti-inflammatory effect, we examined the effects of low-power neodymium-doped yttrium-aluminium-garnet (Nd:YAG) laser irradiation on interleukin (IL)-6 expression in human pulp (HP) cells stimulated by peptidoglycan (PGN) and focused on intracellular signaling pathways. Neodymium 123-132 interleukin 6 Homo sapiens 194-212 19249598-3 2009 In the present study, to elucidate the mechanism behind the anti-inflammatory effect, we examined the effects of low-power neodymium-doped yttrium-aluminium-garnet (Nd:YAG) laser irradiation on interleukin (IL)-6 expression in human pulp (HP) cells stimulated by peptidoglycan (PGN) and focused on intracellular signaling pathways. yttrium-aluminium 139-156 interleukin 6 Homo sapiens 194-212 15471896-0 2005 Up-regulation of interleukin-6 in human ovarian cancer cell via a Gi/PI3K-Akt/NF-kappaB pathway by lysophosphatidic acid, an ovarian cancer-activating factor. lysophosphatidic acid 99-120 interleukin 6 Homo sapiens 17-30 15471896-4 2005 To elucidate the pathogenesis of ovarian cancer, this study investigated how LPA affects IL-6 production in ovarian cancer cells. lysophosphatidic acid 77-80 interleukin 6 Homo sapiens 89-93 15471896-5 2005 Experimental results indicated that LPA stimulates IL-6 expression in all ovarian cancer cell lines tested, but not in normal ovarian surface epithelial (NOSE) cells, owing to the lack of LPA-specific Edg4 and/or Edg7 receptors in NOSE cells. lysophosphatidic acid 36-39 interleukin 6 Homo sapiens 51-55 15471896-6 2005 This work demonstrated that LPA transcriptionally activates IL-6 expression, which can be totally blocked by the pertussis toxin, indicating that Gi-mediated signaling is critically involved in inducing IL-6 by LPA. lysophosphatidic acid 28-31 interleukin 6 Homo sapiens 60-64 15471896-6 2005 This work demonstrated that LPA transcriptionally activates IL-6 expression, which can be totally blocked by the pertussis toxin, indicating that Gi-mediated signaling is critically involved in inducing IL-6 by LPA. lysophosphatidic acid 28-31 interleukin 6 Homo sapiens 203-207 15471896-7 2005 Pharmacological and genetic inhibition assays revealed that Gi-mediated PI3K activation phosphorylated downstream Akt and subsequently induced NF-kappaB activation causes the induction of IL-6 by LPA in SK-OV-3 cells. lysophosphatidic acid 196-199 interleukin 6 Homo sapiens 188-192 15471896-8 2005 In summary, data presented here demonstrate that LPA is an important inducer of IL-6 and LPA-regulated IL-6 expression via a Gi/PI3K-Akt/NF-kappaB pathway in ovarian cancer cells, providing molecular therapeutic targets for treating ovarian cancer. lysophosphatidic acid 49-52 interleukin 6 Homo sapiens 80-84 15471896-8 2005 In summary, data presented here demonstrate that LPA is an important inducer of IL-6 and LPA-regulated IL-6 expression via a Gi/PI3K-Akt/NF-kappaB pathway in ovarian cancer cells, providing molecular therapeutic targets for treating ovarian cancer. lysophosphatidic acid 49-52 interleukin 6 Homo sapiens 103-107 15471896-8 2005 In summary, data presented here demonstrate that LPA is an important inducer of IL-6 and LPA-regulated IL-6 expression via a Gi/PI3K-Akt/NF-kappaB pathway in ovarian cancer cells, providing molecular therapeutic targets for treating ovarian cancer. lysophosphatidic acid 89-92 interleukin 6 Homo sapiens 103-107 15607574-3 2005 Physiological concentrations of insulin as well as of catecholamines have been shown to boost adipocyte production of IL-6 dose-dependently. Catecholamines 54-68 interleukin 6 Homo sapiens 118-122 19240160-0 2009 Interleukin-6 increases prostate cancer cells resistance to bicalutamide via TIF2. bicalutamide 60-72 interleukin 6 Homo sapiens 0-13 8309727-7 1993 Among the same family of antibiotics such as macrolides, differences on cytokine modulation were observed: spiramycin and erythromycin increased IL-6 production while roxithromycin did not exert any significant effect. Spiramycin 107-117 interleukin 6 Homo sapiens 145-149 19240160-5 2009 Herein, we explored an association between IL-6 and bicalutamide resistance. bicalutamide 52-64 interleukin 6 Homo sapiens 43-47 19240160-7 2009 The cells from higher passages of LNCaP treated with IL-6 developed resistance to bicalutamide treatment compared with parental LNCaP cells. bicalutamide 82-94 interleukin 6 Homo sapiens 53-57 8325885-4 1993 The p53 mutants Val-135 and Phe-132 up-regulated IL-6 promoter activity in these cells at both 32.5 and 37 degrees C. The temperature-sensitive Val-135 mutant was not only not inhibitory or "wt-like" at the lower temperature, but had gained a transcriptional activator phenotype which was temperature-independent in HeLa cells. Valine 16-19 interleukin 6 Homo sapiens 49-53 19240160-9 2009 Down-regulation of TIF2 expression via short hairpin RNA in IL-6-treated LNCaP cells sensitized these cells to bicalutamide treatment, whereas overexpression of TIF2 in the parental LNCaP cells increased resistance to bicalutamide. bicalutamide 111-123 interleukin 6 Homo sapiens 60-64 19240160-9 2009 Down-regulation of TIF2 expression via short hairpin RNA in IL-6-treated LNCaP cells sensitized these cells to bicalutamide treatment, whereas overexpression of TIF2 in the parental LNCaP cells increased resistance to bicalutamide. bicalutamide 218-230 interleukin 6 Homo sapiens 60-64 19240160-10 2009 Furthermore, overexpression of IL-6 attenuated bicalutamide-mediated blockage of androgen-induced androgen receptor nuclear translocation and recruitment. bicalutamide 47-59 interleukin 6 Homo sapiens 31-35 19240160-11 2009 These results show that overexpression of IL-6 increases the resistance of prostate cancer cells to bicalutamide via TIF2. bicalutamide 100-112 interleukin 6 Homo sapiens 42-46 19240160-12 2009 Overexpression of IL-6 not only plays an important role in prostate cancer progression but also contributes to bicalutamide resistance. bicalutamide 111-123 interleukin 6 Homo sapiens 18-22 19240160-13 2009 Our studies suggest that bicalutamide-IL-6-targeted adjunctive therapy may lead to a more effective intervention than bicalutamide alone. bicalutamide 25-37 interleukin 6 Homo sapiens 38-42 19240160-13 2009 Our studies suggest that bicalutamide-IL-6-targeted adjunctive therapy may lead to a more effective intervention than bicalutamide alone. bicalutamide 118-130 interleukin 6 Homo sapiens 38-42 15533212-0 2004 Regulation of interleukin-6 expression by arecoline in human buccal mucosal fibroblasts is related to intracellular glutathione levels. Arecoline 42-51 interleukin 6 Homo sapiens 14-27 15533212-5 2004 The effects of arecoline, the major areca nut alkaloid, on IL-6 expression in normal human buccal mucosa fibroblasts (BMFs) were measured in vitro. Arecoline 15-24 interleukin 6 Homo sapiens 59-63 15533212-7 2004 To determine whether glutathione (GSH) levels were important in the induction of IL-6 by arecoline, we pretreated cells with 2-oxothiazolidine-4-carboxylic acid (OTZ) to boost GSH levels or with buthionine sulfoximine (BSO) to deplete GSH. Arecoline 89-98 interleukin 6 Homo sapiens 81-85 15533212-9 2004 The exposure of quiescent BMF to arecoline resulted in the elevation of IL-6 mRNA expression in a dose-dependent manner (P < 0.05). Arecoline 33-42 interleukin 6 Homo sapiens 72-76 15533212-10 2004 IL-6 gene regulated by arecoline correlated with intracellular GSH levels in BMF. Arecoline 23-32 interleukin 6 Homo sapiens 0-4 15533212-11 2004 Arecoline at a concentration of 129 muM induced about 2.7-fold IL-6 mRNA levels over the 6-h incubation period. Arecoline 0-9 interleukin 6 Homo sapiens 63-67 15533212-13 2004 In addition, OTZ was found to marginally reduce the arecoline-induced IL-6 expression by about 1.7-fold (P < 0.05). Arecoline 52-61 interleukin 6 Homo sapiens 70-74 15533212-14 2004 CONCLUSIONS: Taken together, these results suggest that IL-6 expression is significantly upregulated in OSF fibroblasts in areca quid chewers and arecoline may be responsible for the enhanced IL-6 expression. Arecoline 146-155 interleukin 6 Homo sapiens 56-60 15533212-14 2004 CONCLUSIONS: Taken together, these results suggest that IL-6 expression is significantly upregulated in OSF fibroblasts in areca quid chewers and arecoline may be responsible for the enhanced IL-6 expression. Arecoline 146-155 interleukin 6 Homo sapiens 192-196 15533212-15 2004 In addition, the regulation of IL-6 expression induced by arecoline is critically dependent on the intracellular GSH concentrations. Arecoline 58-67 interleukin 6 Homo sapiens 31-35 19182377-3 2009 On the other hand, the size of vacuoles formed by OSM, IL-6, DEX/OSM, or DEX/IL-6 was significantly decreased to about 65% by madindoline A (MDL-A), which is a non-peptide antagonist of gp130 and an inhibitor of cytokines, such as IL-6, mediated by gp130 homodimerization, while RU-486 did not affect the size of vacuoles. madindoline A 126-139 interleukin 6 Homo sapiens 55-59 19182377-3 2009 On the other hand, the size of vacuoles formed by OSM, IL-6, DEX/OSM, or DEX/IL-6 was significantly decreased to about 65% by madindoline A (MDL-A), which is a non-peptide antagonist of gp130 and an inhibitor of cytokines, such as IL-6, mediated by gp130 homodimerization, while RU-486 did not affect the size of vacuoles. madindoline A 126-139 interleukin 6 Homo sapiens 77-81 19182377-3 2009 On the other hand, the size of vacuoles formed by OSM, IL-6, DEX/OSM, or DEX/IL-6 was significantly decreased to about 65% by madindoline A (MDL-A), which is a non-peptide antagonist of gp130 and an inhibitor of cytokines, such as IL-6, mediated by gp130 homodimerization, while RU-486 did not affect the size of vacuoles. madindoline A 126-139 interleukin 6 Homo sapiens 77-81 8325885-4 1993 The p53 mutants Val-135 and Phe-132 up-regulated IL-6 promoter activity in these cells at both 32.5 and 37 degrees C. The temperature-sensitive Val-135 mutant was not only not inhibitory or "wt-like" at the lower temperature, but had gained a transcriptional activator phenotype which was temperature-independent in HeLa cells. Valine 144-147 interleukin 6 Homo sapiens 49-53 19607970-6 2009 These findings proved that inhibition of IL-6 function prevented neuropathic pain caused by vincristine. Vincristine 92-103 interleukin 6 Homo sapiens 41-45 8325885-5 1993 The functional DNA target for transcriptional modulation of the IL-6 promoter by p53 species included the multiple cytokine- and second messenger-response element (-173 to -145); point mutations in the transcription factor C/EBP beta-binding site within the second messenger-response element largely blocked the ability of p53 mutants Val-135 and Phe-132 to up-regulate this promoter. Valine 335-338 interleukin 6 Homo sapiens 64-68 19084961-7 2008 Either Pg-LPS or E-LPS stimulated HGF-1 or THP-1 cells to continuously increase the secretion of IL-6 (P<0.01). e-lps 17-22 interleukin 6 Homo sapiens 97-101 8325885-7 1993 In contrast, the p53 mutants Val-135 and Phe-132 further enhanced C/EBP beta-mediated up-regulation of IL-6 promoter constructs. Valine 29-32 interleukin 6 Homo sapiens 103-107 15385498-1 2004 We have previously demonstrated that human gingival fibroblasts rescue butyric acid-induced T-cell apoptosis via proinflammatory cytokines such as interleukin 6 (IL-6) and IL-11, which are produced by fibroblasts stimulated with butyric acid. Butyric Acid 71-83 interleukin 6 Homo sapiens 147-160 15385498-1 2004 We have previously demonstrated that human gingival fibroblasts rescue butyric acid-induced T-cell apoptosis via proinflammatory cytokines such as interleukin 6 (IL-6) and IL-11, which are produced by fibroblasts stimulated with butyric acid. Butyric Acid 71-83 interleukin 6 Homo sapiens 162-166 7685949-0 1993 Effect of FK 506 and cyclosporine on the expression of IL-6 and its receptor on stimulated monocytes. Tacrolimus 10-16 interleukin 6 Homo sapiens 55-59 15385498-1 2004 We have previously demonstrated that human gingival fibroblasts rescue butyric acid-induced T-cell apoptosis via proinflammatory cytokines such as interleukin 6 (IL-6) and IL-11, which are produced by fibroblasts stimulated with butyric acid. Butyric Acid 229-241 interleukin 6 Homo sapiens 147-160 15385498-1 2004 We have previously demonstrated that human gingival fibroblasts rescue butyric acid-induced T-cell apoptosis via proinflammatory cytokines such as interleukin 6 (IL-6) and IL-11, which are produced by fibroblasts stimulated with butyric acid. Butyric Acid 229-241 interleukin 6 Homo sapiens 162-166 19186329-6 2008 Waist circumference (R = 0.491, P = 0.007) and cortisol AUC (R = -0.415, P = 0.03) were significant determinants of the magnitude of 6h changes in plasma IL-6 after the meals. 6H 133-135 interleukin 6 Homo sapiens 154-158 18762411-7 2008 Among the PPARgamma ligands tested in this study, ciglitazone, a synthetic agonist of PPARgamma, effectively inhibited IL-6 production, but while neither rosiglitazone nor 15-deoxy-Delta(12,14)-prostaglandin J2 did. ciglitazone 50-61 interleukin 6 Homo sapiens 119-123 8496855-1 1993 OBJECTIVE: To determine the clinical utility and the effect of sodium aurothiomalate (GSTM) on serum interleukin 6 (IL-6) levels in patients with rheumatoid arthritis (RA). Gold Sodium Thiomalate 63-84 interleukin 6 Homo sapiens 101-114 18632424-0 2008 Pravastatin immunomodulates IL-6 and C-reactive protein, but not IL-1 and TNF-alpha, in cardio-pulmonary bypass. Pravastatin 0-11 interleukin 6 Homo sapiens 28-32 18632424-7 2008 RESULTS: Pravastatin reduced postoperative interleukin-6 (IL-6) levels significantly at 24 and 48 hours, and at seven days. Pravastatin 9-20 interleukin 6 Homo sapiens 43-56 18632424-7 2008 RESULTS: Pravastatin reduced postoperative interleukin-6 (IL-6) levels significantly at 24 and 48 hours, and at seven days. Pravastatin 9-20 interleukin 6 Homo sapiens 58-62 18632424-11 2008 CONCLUSIONS: Pravastatin induced a precocious modulation of IL-6 expression and a later reduction of plasma CRP levels. Pravastatin 13-24 interleukin 6 Homo sapiens 60-64 15469788-0 2004 [Effect of the early administration of pravastatin on C-reactive protein and interleukin-6 levels in the acute phase of myocardial infarction with ST segment elevation]. Pravastatin 39-50 interleukin 6 Homo sapiens 77-90 15469788-2 2004 The aim of this study was to evaluate the effect of early administration of pravastatin on plasma levels of CRP and IL-6 in patients with acute myocardial infarction and ST segment elevation. Pravastatin 76-87 interleukin 6 Homo sapiens 116-120 15229366-8 2004 The aqueous fraction of ROFA also contained potent IL-6 inducing activity in concert with MALP-2, and exposure to several defined metal salts indicated that Ni and, to a lesser extent V, (but not Cu) could synergistically act with MALP-2 to induce IL-6. rofa 24-28 interleukin 6 Homo sapiens 51-55 15229366-8 2004 The aqueous fraction of ROFA also contained potent IL-6 inducing activity in concert with MALP-2, and exposure to several defined metal salts indicated that Ni and, to a lesser extent V, (but not Cu) could synergistically act with MALP-2 to induce IL-6. rofa 24-28 interleukin 6 Homo sapiens 248-252 8496855-1 1993 OBJECTIVE: To determine the clinical utility and the effect of sodium aurothiomalate (GSTM) on serum interleukin 6 (IL-6) levels in patients with rheumatoid arthritis (RA). Gold Sodium Thiomalate 63-84 interleukin 6 Homo sapiens 116-120 18393231-7 2008 Girls with CC genotype of IL-6 -634G/C gene had higher percentage of increase in BMD of total body (P= 0.027) and femoral trochanter (P= 0.028) than those with CG+ GG genotypes. cysteinylglycine 160-162 interleukin 6 Homo sapiens 26-30 8099204-0 1993 Human astrocyte production of tumour necrosis factor-alpha, interleukin-1 beta, and interleukin-6 following exposure to lipopolysaccharide endotoxin. lipopolysaccharide endotoxin 120-148 interleukin 6 Homo sapiens 84-97 18171700-8 2008 The effects of LPA on the expression of IL-6, IL-8, and vascular endothelial growth factor were examined. lysophosphatidic acid 15-18 interleukin 6 Homo sapiens 40-44 18171700-14 2008 LPA induced IL-8 and IL-6 through different pathways. lysophosphatidic acid 0-3 interleukin 6 Homo sapiens 21-25 15460412-9 2004 The IL-6 concentration in ciglitazone groups is lower than that in control group (P<0.01). ciglitazone 26-37 interleukin 6 Homo sapiens 4-8 8510328-6 1993 The growth of S6B45 was definitely inhibited by anti-IL-6 (MH166) or anti-IL-6 receptor (PM1) monoclonal antibodies. mh166 59-64 interleukin 6 Homo sapiens 53-57 15345737-6 2004 RESULTS: The serum beta-carotene concentration was inversely associated with C-reactive protein and interleukin-6 levels. beta Carotene 19-32 interleukin 6 Homo sapiens 100-113 18171700-15 2008 LPA-induced IL-8 and IL-6 increased permeability of human umbilical vein endothelial cell monolayer. lysophosphatidic acid 0-3 interleukin 6 Homo sapiens 21-25 18171700-16 2008 CONCLUSIONS: LPA induces IL-8 and IL-6 expressions through LPA receptors and nuclear factor-kappaB dependent pathways in granulosa-lutein cells. lysophosphatidic acid 13-16 interleukin 6 Homo sapiens 34-38 18171700-18 2008 Large amounts of LPA-induced IL-8 and IL-6 from multiple corpora luteae of stimulated ovaries may be one of the pathophysiological causes of ovarian hyperstimulation syndrome. lysophosphatidic acid 17-20 interleukin 6 Homo sapiens 38-42 15197140-9 2004 Interleukin-6 (P=0.04) and C-reactive protein (P=0.02) decreased more in the repaglinide group than in the glyburide group. repaglinide 77-88 interleukin 6 Homo sapiens 0-13 8381666-2 1993 Exposure of cells to 0.1 U/ml of sphingomyelinase led to the degradation of 75, 55 and 40% of the cellular total sphingomyelin mass in human skin fibroblasts (HSF), Chinese hamster lung fibroblasts (CHLF) and rat liver hepatocytes (RLH), respectively. Sphingomyelins 33-46 interleukin 6 Homo sapiens 159-162 15024019-0 2004 Interleukin 6 mediates the lysophosphatidic acid-regulated cross-talk between stromal and epithelial prostate cancer cells. lysophosphatidic acid 27-48 interleukin 6 Homo sapiens 0-13 18031794-0 2008 Suppression of IL-6 level in human peripheral blood mononuclear cells stimulated with PHA/LPS after occupational exposure to chromium. Chromium 125-133 interleukin 6 Homo sapiens 15-19 1289500-2 1992 In vitro effects of 3-formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-on e (T-614), a novel antiinflammatory compound, on the production of interleukin-1 (IL-1) and/or interleukin-6 (IL-6) by human monocytes and the THP-1 cells of a human monocytic cell line, were examined. 3-formylamino-7-methylsulfonylamino-6-phenoxy-4h-1-benzopyran-4 20-83 interleukin 6 Homo sapiens 182-195 18006645-5 2008 Moreover, exogenously applied LPA induces FLS migration and secretion of IL-8/IL-6, whereas the LPA(3) agonist l-sn-1-O-oleoyl-2-methyl-glyceryl-3-phosphothionate (2S-OMPT) stimulates cytokine synthesis but not cell motility. lysophosphatidic acid 30-33 interleukin 6 Homo sapiens 78-82 15024019-8 2004 Protein analysis demonstrates that treatment of the PS30 cells with LPA induces synthesis of interleukin 6 (IL-6). lysophosphatidic acid 68-71 interleukin 6 Homo sapiens 93-106 15024019-8 2004 Protein analysis demonstrates that treatment of the PS30 cells with LPA induces synthesis of interleukin 6 (IL-6). lysophosphatidic acid 68-71 interleukin 6 Homo sapiens 108-112 14737074-2 2004 We found that the treatment with MAP/ERK kinase 1 (MEK1) inhibitors PD98059 or PD184352 produced a reduction of phosphorylated ERK1/2 (p-ERK1/2) levels in myeloma cells of more than 80% and prevented the increase of p-ERK1/2 induced by interleukin-6 (IL-6). 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide 79-87 interleukin 6 Homo sapiens 236-249 14737074-2 2004 We found that the treatment with MAP/ERK kinase 1 (MEK1) inhibitors PD98059 or PD184352 produced a reduction of phosphorylated ERK1/2 (p-ERK1/2) levels in myeloma cells of more than 80% and prevented the increase of p-ERK1/2 induced by interleukin-6 (IL-6). 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide 79-87 interleukin 6 Homo sapiens 251-255 18234565-6 2008 Baseline values were different between the two groups, but an altered pattern of release was observed for TNFa, IL-6, IL-10 and beta-endorphin levels in patients treated with catecholamines. Catecholamines 175-189 interleukin 6 Homo sapiens 112-116 1289500-2 1992 In vitro effects of 3-formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-on e (T-614), a novel antiinflammatory compound, on the production of interleukin-1 (IL-1) and/or interleukin-6 (IL-6) by human monocytes and the THP-1 cells of a human monocytic cell line, were examined. 3-formylamino-7-methylsulfonylamino-6-phenoxy-4h-1-benzopyran-4 20-83 interleukin 6 Homo sapiens 197-201 17904601-13 2007 In vitro evidence shows that Pb strongly binds to GRP78, induces GRP78 aggregation, and blocks IL-6 secretion in astroglial cells. Lead 29-31 interleukin 6 Homo sapiens 95-99 14977303-7 2004 We conclude that the volatile sulfur compound CH3SH plays a role in activation and modulation of the immune response through its role in production of IL-6. Sulfur 30-36 interleukin 6 Homo sapiens 151-155 1520119-4 1992 Recombinant human interleukin 6 in phosphate-buffered saline at concentrations of 0.1, 0.3, or 1 mg/L was administered immediately after the epithelium was debrided with the n-heptyl alcohol treatment and 2, 4, 6, 8, 10, 18, 20, 22, 24, 26, and 28 hours after debridement. Phosphate-Buffered Saline 35-60 interleukin 6 Homo sapiens 18-31 15630177-3 2004 Surprisingly, zerumbone markedly induced the expression of interleukin (IL)-1alpha, IL-1beta, IL-6, and tumor necrosis factor (TNF)-alpha in each cell line in concentration- and time-dependent manners. zerumbone 14-23 interleukin 6 Homo sapiens 94-98 17823083-0 2007 Influence of the selective oestrogen receptor modulator (raloxifene hydrochloride) on IL-6, TNF-alpha, TGF-beta1 and bone turnover markers in the treatment of postmenopausal osteoporosis. Raloxifene Hydrochloride 57-81 interleukin 6 Homo sapiens 86-90 1505915-0 1992 Differential effects of chenodeoxycholic and ursodeoxycholic acids on interleukin 1, interleukin 6 and tumor necrosis factor-alpha production by monocytes. Ursodeoxycholic Acid 45-66 interleukin 6 Homo sapiens 85-130 17040605-8 2007 Our results showed that IL-5, IL-6 and IL-8 in both the AR and NAR groups were strikingly elevated in comparison with the control group (all p < 0.01 for AR group; p < 0.05, 0.05, 0.01, respectively, for NAR group); and they were even higher in the AR group than those in the NAR group (p < 0.01, 0.05, 0.01, respectively). Argon 56-58 interleukin 6 Homo sapiens 30-34 17395587-3 2007 In this study we investigate the effects of common asthma treatments fluticasone propionate and beta(2) agonists salmeterol and salbutamol on IL-6 production in BEAS-2B and primary bronchial epithelial cells. Fluticasone 69-91 interleukin 6 Homo sapiens 142-146 14755127-3 2004 Divaricatum (Asteraceae) in terms of protection against sunburn, and in prevention of UVB-induced pyrimidine dimer formation and IL-6 mRNA expression in the human keratinocyte cell line, HaCaT. divaricatum 0-11 interleukin 6 Homo sapiens 129-133 17395587-4 2007 Salmeterol and salbutamol enhanced rhinovirus- and IL-1beta-induced IL-6 production; however, fluticasone treatment caused a reduction of IL-6 protein and mRNA. Fluticasone 94-105 interleukin 6 Homo sapiens 138-142 1610348-0 1992 Phosphorylation of interleukin-6 at serine54: an early event in the secretory pathway in human fibroblasts. serine54 36-44 interleukin 6 Homo sapiens 19-32 17346688-3 2007 This study was to determine if selenium can repress IL-6 mediated AR action in PCa progression. Selenium 31-39 interleukin 6 Homo sapiens 52-56 14682409-4 2003 RESULTS: The pleural fluid Levels of IL-6, TNF-alpha and IFN-gamma in TB patients were significantly higher than those with non-TB effusions (P values of <0.001, 0.018 and <0.001, respectively by independent t-test). Terbium 70-72 interleukin 6 Homo sapiens 37-41 1319454-4 1992 IL-6 release over 24 h was stimulated by TSH (5000 microU/ml), by forskolin (0.01 mmol/l), by fetal calf serum (1-20%) and by epidermal growth factor (20 ng/ml). Thyrotropin 41-44 interleukin 6 Homo sapiens 0-4 14556080-7 2003 Cerivastatin also reduced the C5b-9-induced synthesis of the proinflammatory interleukin-6 (IL-6). cerivastatin 0-12 interleukin 6 Homo sapiens 77-90 1730219-3 1992 Native IL-6 was purified from human blood mononuclear cells and the oligosaccharides released, radiolabelled and sequenced by a combination of sequential exoglycosidase digestion using Bio-Gel P-4 high-resolution gel chromatography and acetolysis. Oligosaccharides 68-84 interleukin 6 Homo sapiens 7-11 14556080-7 2003 Cerivastatin also reduced the C5b-9-induced synthesis of the proinflammatory interleukin-6 (IL-6). cerivastatin 0-12 interleukin 6 Homo sapiens 92-96 17218328-4 2007 RESULTS: Inhibition of NF-kappaB by a novel agent, RO100 at a dose of 0.1 microM, exerted significant (P < 0.05) repression of IL-6, MMP-1 and MMP-3 production in OA-SF. ro100 51-56 interleukin 6 Homo sapiens 130-134 14556080-10 2003 The present study in VSMCs shows that cerivastatin inhibits IL-6 synthesis and cell proliferation induced by the terminal complement complex C5b-9. cerivastatin 38-50 interleukin 6 Homo sapiens 60-64 1384862-0 1992 The effects of FK-506 and cyclosporin A on the proliferation of PHA-stimulated T cells in response to IL-2, IL-4 or IL-6. Tacrolimus 15-21 interleukin 6 Homo sapiens 116-120 1790549-1 1991 The effects of the xanthine derivative propentofylline on the production of interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta), and tumor necrosis factor-alpha (TNF-alpha) by human peripheral blood mononuclear cells (PBMCs) were studied. propentofylline 39-54 interleukin 6 Homo sapiens 76-89 1660901-0 1991 Time course of IL1 and IL6 synthesis and release in human bronchial epithelial cell cultures exposed to toluene diisocyanate. Toluene 2,4-Diisocyanate 104-124 interleukin 6 Homo sapiens 23-26 14592603-5 2003 Moreover, chloroquine has immunomodulatory effects, suppressing the production/release of tumour necrosis factor alpha and interleukin 6, which mediate the inflammatory complications of several viral diseases. Chloroquine 10-21 interleukin 6 Homo sapiens 123-136 14523327-2 2003 Catecholamines, used under clinical conditions to maintain adequate cerebral perfusion pressure, induce a sustained IL-6 release. Catecholamines 0-14 interleukin 6 Homo sapiens 116-120 12891120-7 2003 RESULTS: PGE(2) or 11-deoxy-PGE(1) (EP 2/3/4 agonist) reversed partially the indomethacin suppression of IL-6 secretion from explant cultures, whereas butaprost (EP2 receptor agonist) and sulprostone (EP 1/3 receptor agonist) had no effect. Indomethacin 77-89 interleukin 6 Homo sapiens 105-109 17307798-1 2007 CD160 NK cell-activating receptor is a glycosyl-phosphatidylinositol-anchored molecule that, upon specific engagement, triggers both cytotoxicity and a unique cytokine production [IFN-gamma, tumor necrosis factor-alpha (TNF-alpha) and IL-6] through an undefined signaling pathway. Glycosylphosphatidylinositols 39-68 interleukin 6 Homo sapiens 235-239 17078813-10 2007 The results suggest that Cr(VI) activates epithelial cell Lck to signal for prolonged STAT3 activation and transactivation of IL-6, an important immunomodulator of lung disease progression. Chromium 25-27 interleukin 6 Homo sapiens 126-130 17081715-4 2007 During 24-72 h of incubation with a low (2x10(4) HSF cells/mL) density of cells, significant cytotoxicity was observed for methanol and ethyl acetate extracts at concentrations greater than 125 microg/mL. ethyl acetate 136-149 interleukin 6 Homo sapiens 49-52 12732938-8 2003 Total intracellular PL contents were also unchanged; however, IL-6 led to significant changes in PL composition including an increase in phosphatidylethanolamine (PE) and sphingomyelin (SM) and a decrease in phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) ( p<0.05). phosphatidylethanolamine 137-161 interleukin 6 Homo sapiens 62-66 1660901-1 1991 We have previously demonstrated that human bronchial epithelial cells release appreciable amounts of interleukin 1 (IL1) and interleukin 6 (IL6) when exposed to toluene diisocyanate (TDI) in vitro. Toluene 2,4-Diisocyanate 161-181 interleukin 6 Homo sapiens 125-138 12732938-8 2003 Total intracellular PL contents were also unchanged; however, IL-6 led to significant changes in PL composition including an increase in phosphatidylethanolamine (PE) and sphingomyelin (SM) and a decrease in phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) ( p<0.05). phosphatidylethanolamine 163-165 interleukin 6 Homo sapiens 62-66 1660901-1 1991 We have previously demonstrated that human bronchial epithelial cells release appreciable amounts of interleukin 1 (IL1) and interleukin 6 (IL6) when exposed to toluene diisocyanate (TDI) in vitro. Toluene 2,4-Diisocyanate 161-181 interleukin 6 Homo sapiens 140-143 1660901-1 1991 We have previously demonstrated that human bronchial epithelial cells release appreciable amounts of interleukin 1 (IL1) and interleukin 6 (IL6) when exposed to toluene diisocyanate (TDI) in vitro. Toluene 2,4-Diisocyanate 183-186 interleukin 6 Homo sapiens 125-138 1660901-1 1991 We have previously demonstrated that human bronchial epithelial cells release appreciable amounts of interleukin 1 (IL1) and interleukin 6 (IL6) when exposed to toluene diisocyanate (TDI) in vitro. Toluene 2,4-Diisocyanate 183-186 interleukin 6 Homo sapiens 140-143 12762338-0 2003 Fluticasone reduces IL-6 and IL-8 production of cystic fibrosis bronchial epithelial cells via IKK-beta kinase pathway. Fluticasone 0-11 interleukin 6 Homo sapiens 20-24 17326846-7 2007 CONCLUSION: Direct comparisons of manufactured metal oxide nanoparticles and previously studied types of particles and surrogate proinflammatory agonists showed that the metal oxide particles have low potency to induce IL-6 secretion in BEAS-2B cells. metal oxide 170-181 interleukin 6 Homo sapiens 219-223 1660901-3 1991 The epithelial cell-derived IL1 and IL6 can promote T cell activation and proliferation in culture, and if this also happens in vivo they may contribute to the persistence of the inflammatory response of the bronchial mucosa observed in TDI-sensitive asthmatics. Toluene 2,4-Diisocyanate 237-240 interleukin 6 Homo sapiens 36-39 18240867-8 2007 In patients who stopped taking stavudine or zidovudine, the number of TNFalpha- and IL6-expressing cells was lower at month 6 than at month 0, and so was CD68 expression, a macrophage marker. Stavudine 31-40 interleukin 6 Homo sapiens 84-87 1660901-5 1991 In the epithelial cell cultures exposed to TDI, there was a parallel, progressive increase in the expression of IL6 mRNA and in the secretion of IL6 protein between 48 hours and 6 days after exposure. Toluene 2,4-Diisocyanate 43-46 interleukin 6 Homo sapiens 112-115 1660901-5 1991 In the epithelial cell cultures exposed to TDI, there was a parallel, progressive increase in the expression of IL6 mRNA and in the secretion of IL6 protein between 48 hours and 6 days after exposure. Toluene 2,4-Diisocyanate 43-46 interleukin 6 Homo sapiens 145-148 12543059-5 2003 The pre-treatment of cells with pravastatin diminished the capacity of Abeta to induce metalloproteinases, cytokine IL-6 and free radical levels. Pravastatin 32-43 interleukin 6 Homo sapiens 116-120 1759822-5 1991 Spiramycin and, to a lesser extent, erythromycin increased total IL-6 production without affecting IL-1 alpha, IL-1 beta, or tumor necrosis factor alpha production, whereas roxithromycin had no effect. Spiramycin 0-10 interleukin 6 Homo sapiens 65-69 12509619-0 2003 The active metabolite of leflunomide, A77 1726, inhibits the production of prostaglandin E(2), matrix metalloproteinase 1 and interleukin 6 in human fibroblast-like synoviocytes. Leflunomide 25-36 interleukin 6 Homo sapiens 126-139 12509619-10 2003 CONCLUSION: This study shows that some of the beneficial effect of leflunomide in RA patients may be due to the inhibition of PGE(2), IL-6 and MMP-1 production in synoviocytes. Leflunomide 67-78 interleukin 6 Homo sapiens 134-138 17331441-6 2007 Indomethacin significantly inhibited IL-6 and IL-11 production in LPS-stimulated HGF. Indomethacin 0-12 interleukin 6 Homo sapiens 37-41 17023036-8 2006 RESULTS: The IL6 -174 genotype frequencies of CC (19%), CG (50%), and GG (31%) were in Hardy-Weinberg equilibrium and were similar to published frequencies in Caucasian controls. cysteinylglycine 56-58 interleukin 6 Homo sapiens 13-16 1718855-3 1991 Although MH166 completely neutralized hIL-6 activity in vitro, treatment in vivo with hIL-6 and MH166 combined unexpectedly increased both anti-dinitrophenyl (DNP) and anti-sheep red blood cell (SRBC) antibody production more than treatment with IL-6 alone did. mh166 96-101 interleukin 6 Homo sapiens 38-43 2015887-2 1991 Single substitution Met162----Ala and double substitutions Leu159.166----Val resulted in a significant decrease of IL-6 activity in the production of immunoglobulin (Ig) from B-cells. Valine 70-76 interleukin 6 Homo sapiens 115-119 16497336-6 2006 PMF supplementation also reduced TG contents in the liver and heart and was able to regulate adipocytokines by significantly suppressing TNF-alpha, INF-gamma, IL-1beta and IL-6 expression and increasing adiponectin in IR hamsters. Phenylmethylsulfonyl Fluoride 0-3 interleukin 6 Homo sapiens 172-176 12429044-9 2002 The ratio of serum IL-6/TNF was positively correlated with the ratio of serum cortisol/DHEA (R(Rank)=0.472, P=0.041) and serum cortisol/17OH-progesterone (R(Rank)=0.514, P=0.048). 17-alpha-Hydroxyprogesterone 136-153 interleukin 6 Homo sapiens 19-23 12237173-10 2002 Pretreating the cells with the 3-hydroxy-3-methylglutaryl CoA (HMG CoA) reductase inhibitor Cerivastatin reduced IL-6 release. cerivastatin 92-104 interleukin 6 Homo sapiens 113-117 2208809-7 1990 Pretreatment of PBMC with leucine-methyl ester to deplete monocytes reduced the rC5a-induced IL-6 production to background levels. PBMC 16-20 interleukin 6 Homo sapiens 93-97 12242082-4 2002 This study investigated the effect of five days of oral indomethacin treatment (75 mg per day) on the serum concentrations of IL-6, IL-10, IL-12, and TNF-alpha induced by exercising healthy volunteers. Indomethacin 56-68 interleukin 6 Homo sapiens 126-130 16418198-0 2006 Chloroquine inhibits production of TNF-alpha, IL-1beta and IL-6 from lipopolysaccharide-stimulated human monocytes/macrophages by different modes. Chloroquine 0-11 interleukin 6 Homo sapiens 59-63 16322071-6 2006 Gallic acid decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated pro-inflammatory cytokine gene expression and production such as TNF-alpha and IL-6 in human mast cells. Gallic Acid 0-11 interleukin 6 Homo sapiens 178-182 2208809-7 1990 Pretreatment of PBMC with leucine-methyl ester to deplete monocytes reduced the rC5a-induced IL-6 production to background levels. leucine methyl ester 26-46 interleukin 6 Homo sapiens 93-97 12242082-7 2002 During and after strenuous physical exercise, indomethacin treatment blunted serum IL-6, and augmented TNF-alpha and IL-10. Indomethacin 46-58 interleukin 6 Homo sapiens 83-87 2174456-6 1990 Exogenous recombinant IL-6 reduced cyclic AMP production in response to TSH when added to thyroid cell cultures. Thyrotropin 72-75 interleukin 6 Homo sapiens 22-26 12067409-6 2002 Treatment of the cells with actinomycin D inhibited IL-6 expression in response to MG-132, suggesting the transcriptional upregulation of IL-6 under proteasomal inhibition. Dactinomycin 28-41 interleukin 6 Homo sapiens 52-56 12067409-6 2002 Treatment of the cells with actinomycin D inhibited IL-6 expression in response to MG-132, suggesting the transcriptional upregulation of IL-6 under proteasomal inhibition. Dactinomycin 28-41 interleukin 6 Homo sapiens 138-142 15935550-0 2006 Hypericin-mediated photodynamic therapy elicits differential interleukin-6 response in nasopharyngeal cancer. hypericin 0-9 interleukin 6 Homo sapiens 61-74 1715769-3 1990 Oligosaccharide analysis of recombinant IL 6 utilizing tunicamycin and endoglycosidases revealed O- and N-linked glycosylation that is comparable to that of natural IL 6 derived from human monocytes and fibroblasts. Oligosaccharides 0-15 interleukin 6 Homo sapiens 40-44 2194956-5 1990 Diclofenac abolished the urinary interleukin-6 response but reduced the PMNL response and bacterial clearance only at the highest concentrations. Diclofenac 0-10 interleukin 6 Homo sapiens 33-46 16690518-5 2006 In univariate analysis, sIL-2R and IL-6 demonstrated prognostic significance for CR (p = 0.016 and p = 0.048), OS (p = 0.0011 and p = 0.0387) and FFS (p = 0.0001 and p = 0.0363), but multi-variate analysis failed to demonstrate an independent prognostic significance. Chromium 81-83 interleukin 6 Homo sapiens 35-39 16690518-7 2006 In conclusion, sIL-2R and IL-6 serum levels are elevated in high grade NHL and are correlated to CR, OS and FFS, but this study did not support their independent prognostic value. Chromium 97-99 interleukin 6 Homo sapiens 26-30 11929636-6 2002 The levels of secreted cytokines, interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) were both increased by the LPS treatment although exposure to Al decreased the secretion of the former while elevating the levels of the latter. Aluminum 161-163 interleukin 6 Homo sapiens 49-53 12133393-1 2002 OBJECTIVE: To investigate the inhibition of IL-6 antisense oligonucleotide (ASON) on IL-6 expression by retinal pigment epithelium (RPE) cells on the basis of previous study. Oligonucleotides, Antisense 76-80 interleukin 6 Homo sapiens 44-48 2119190-3 1990 Among the agents affecting the signal transduction pathways, forskolin significantly induced PSTI secretion whereas PMA or A23187 did not, suggesting that IL-6 induced PSTI secretion is mediated by cAMP dependent protein kinase A. Calcimycin 123-129 interleukin 6 Homo sapiens 155-159 12133393-1 2002 OBJECTIVE: To investigate the inhibition of IL-6 antisense oligonucleotide (ASON) on IL-6 expression by retinal pigment epithelium (RPE) cells on the basis of previous study. Oligonucleotides, Antisense 76-80 interleukin 6 Homo sapiens 85-89 11842936-3 2002 Indomethacin, a cyclooxygenase inhibitor, significantly enhanced IL-1beta-induced IL-6 production by HGF, although it completely inhibited IL-1beta-induced PGE2 production. Indomethacin 0-12 interleukin 6 Homo sapiens 82-86 16507455-8 2006 The particles showed positive correlation between IL-6 release and the elemental and pyrolyzable carbon fractions, and the strongest correlation involving crustal elements was between IL-6 release and the aluminum:silicon ratio. Aluminum 205-213 interleukin 6 Homo sapiens 184-188 16054696-5 2006 Here, we show that pravastatin and simvastatin prevent the induction of CRP expression in human hepatoma Hep3B cells exposed to proinflammatory cytokines IL-6 and IL-1beta The nitric oxide (NO) donor, sodium nitroprusside, also prevented the induction of CRP expression while the CRP inducers IL-6 and IL-1beta were present with the cells. Pravastatin 19-30 interleukin 6 Homo sapiens 154-158 34332882-0 2022 Prevention of IL-6 signaling ameliorates toluene diisocyanate-induced steroid-resistant asthma. Toluene 2,4-Diisocyanate 41-61 interleukin 6 Homo sapiens 14-18 16054696-5 2006 Here, we show that pravastatin and simvastatin prevent the induction of CRP expression in human hepatoma Hep3B cells exposed to proinflammatory cytokines IL-6 and IL-1beta The nitric oxide (NO) donor, sodium nitroprusside, also prevented the induction of CRP expression while the CRP inducers IL-6 and IL-1beta were present with the cells. Pravastatin 19-30 interleukin 6 Homo sapiens 293-297 16354768-6 2006 Moreover, the JAK2 inhibitor alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide (AG-490) abolished PA-induced IL-1beta and IL-6 release but not TNF-alpha production, which is consistent with the notion that IL-1beta and IL-6 but not TNF-alpha contain a STAT binding element in their promoter region. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 29-74 interleukin 6 Homo sapiens 118-122 16354768-6 2006 Moreover, the JAK2 inhibitor alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide (AG-490) abolished PA-induced IL-1beta and IL-6 release but not TNF-alpha production, which is consistent with the notion that IL-1beta and IL-6 but not TNF-alpha contain a STAT binding element in their promoter region. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 29-74 interleukin 6 Homo sapiens 215-219 16354768-6 2006 Moreover, the JAK2 inhibitor alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide (AG-490) abolished PA-induced IL-1beta and IL-6 release but not TNF-alpha production, which is consistent with the notion that IL-1beta and IL-6 but not TNF-alpha contain a STAT binding element in their promoter region. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 76-82 interleukin 6 Homo sapiens 118-122 16354768-6 2006 Moreover, the JAK2 inhibitor alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide (AG-490) abolished PA-induced IL-1beta and IL-6 release but not TNF-alpha production, which is consistent with the notion that IL-1beta and IL-6 but not TNF-alpha contain a STAT binding element in their promoter region. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 76-82 interleukin 6 Homo sapiens 215-219 11935498-3 2002 An increase in haptoglobin is induced by cytocines like IL-6 und IL-1. cytocines 41-50 interleukin 6 Homo sapiens 56-60 11694529-8 2002 Finally, 1,4-dihydroquinone blocks the induction of TNF-alpha target genes interleukin 1beta and interleukin 6 at both mRNA and protein levels. 1,4-dihydroquinone 9-27 interleukin 6 Homo sapiens 97-110 11916128-7 2002 The histamine-induced up-regulation of IL-6 and IL-8 production, however, was completely abrogated by a combination of pyrilamine and cimetidine. Cimetidine 134-144 interleukin 6 Homo sapiens 39-43 34812477-8 2022 Furthermore, simvastatin administration significantly decreased ROS production and the concentrations of TNF-alpha and IL-6, which were significantly increased in neutrophils isolated from the SP group. Simvastatin 13-24 interleukin 6 Homo sapiens 119-123 11766169-6 2001 Four other 8-ketotrichothecenes, fusarenon X, nivalenol, 3-acetyl DON, and 15-acetyl DON, were also capable of upregulating or suppressing TNF-alpha, IL-6, and IL-8 production at concentrations similar to that of DON. ZINC33650233 75-88 interleukin 6 Homo sapiens 150-154 11739438-17 2001 Similarly, IL-6 correlated negatively with total T (r = -0.39; P = 0.0040) and androstenedione (r = -0.27; P = 0.048) in hypopituitary patients. Androstenedione 79-94 interleukin 6 Homo sapiens 11-15 16477544-0 2006 Chromium chloride inhibits TNFalpha and IL-6 secretion in isolated human blood mononuclear cells exposed to high glucose. chromous chloride 0-17 interleukin 6 Homo sapiens 40-44 16368488-9 2006 CO(2)-pneumoperitoneum increased survival at 48 hours compared with LPS control (P <.05), and decreased interleukin-6 plasma levels at 2 hours (P <.05). Carbon Dioxide 0-5 interleukin 6 Homo sapiens 107-120 34288819-6 2021 Firstly, we found that Anagliptin treatment ameliorated the elevated secretions of tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), and macrophage chemoattractant protein-1 (MCP-1). anagliptin 23-33 interleukin 6 Homo sapiens 124-137 16368488-10 2006 Abdominal insufflation with CO(2) before the performance of a laparotomy contaminated with endotoxin increases survival and attenuates interleukin-6. Carbon Dioxide 28-33 interleukin 6 Homo sapiens 135-148 11903746-12 2001 Interleukin-6 production increased to 288 +/- 48, 1195 +/- 86 and 247 +/- 35 pg/mL per 10(6) cells after ethanol, acetaldehyde and LPS exposure, and increased further with LPS pretreatment in ethanol-exposed cells (680 +/- 23 pg/mL 10(6) cells). Acetaldehyde 114-126 interleukin 6 Homo sapiens 0-13 34288819-6 2021 Firstly, we found that Anagliptin treatment ameliorated the elevated secretions of tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), and macrophage chemoattractant protein-1 (MCP-1). anagliptin 23-33 interleukin 6 Homo sapiens 139-143 16761500-7 2006 After three-months of chloroquine therapy the mean level of IL-6, IL-18 and TNF-alpha decreased significantly. Chloroquine 22-33 interleukin 6 Homo sapiens 60-64 34624172-2 2021 Besides the antimicrobial activities against bacteria, fungi and viruses, Ala has also demonstrated significant anti-inflammatory effects in various models by inhibiting NF-kappaB and MAPKs to decrease the pro-inflammatory cytokines such as IL-1beta, IL-6 and TNF-alpha. alantolactone 74-77 interleukin 6 Homo sapiens 251-255 16393327-6 2005 Fluticasone propionate caused a reduction in symptoms, total leukocyte counts and eosinophils, and abrogation of IL-4, IL-5, IL-6 and IL-13 responses in the filter paper taken in the late phase (P < 0.05 for IL-4 and IL-13, P < 0.01 for IL-5 and IL-6). Fluticasone 0-22 interleukin 6 Homo sapiens 125-129 16393327-6 2005 Fluticasone propionate caused a reduction in symptoms, total leukocyte counts and eosinophils, and abrogation of IL-4, IL-5, IL-6 and IL-13 responses in the filter paper taken in the late phase (P < 0.05 for IL-4 and IL-13, P < 0.01 for IL-5 and IL-6). Fluticasone 0-22 interleukin 6 Homo sapiens 252-256 11349061-8 2001 Glucan (1 microg/ml) stimulated fibroblast NF-kappaB nuclear binding activity and interleukin 6 (IL-6) gene expression in a time-dependent manner. Glucans 0-6 interleukin 6 Homo sapiens 82-95 11349061-8 2001 Glucan (1 microg/ml) stimulated fibroblast NF-kappaB nuclear binding activity and interleukin 6 (IL-6) gene expression in a time-dependent manner. Glucans 0-6 interleukin 6 Homo sapiens 97-101 11349061-9 2001 NF-kappaB was activated at 4, 8, and 12 h, while IL-6 mRNA levels were increased by 48% at 8 h. This is the first report of pattern recognition receptors for glucan on human fibroblasts and the first demonstration of glucan binding sites on cells other than leukocytes. Glucans 158-164 interleukin 6 Homo sapiens 49-53 34562102-10 2021 In addition, IL-1beta and TNF-alpha instead of IL-6 in osteoarthritic IPFP-derived FCM played key roles in cartilage degradation via activating p38MAPK rather than ERK1/2 signaling pathway. ipfp 70-74 interleukin 6 Homo sapiens 47-51 11378323-10 2001 But NiCl2 increased IL-1alpha, IL-6 and IL-8 mRNA levels in HMVEC, while DNCB increased only their IL-6 mRNA levels. Dinitrochlorobenzene 73-77 interleukin 6 Homo sapiens 99-103 16287972-5 2005 Furthermore, AG490, a Jak-specific inhibitor, and dominant negative Stat5 only reduced LPS-induced IL-6 production. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 13-18 interleukin 6 Homo sapiens 99-103 34861664-8 2022 In our experiments, pinitol reduced the production of ROS and expression of IL-6 and MCP-1 induced by ox-LDL. pinitol 20-27 interleukin 6 Homo sapiens 76-80 16216004-8 2005 In patients treated with LMWH, the plasma levels of IL-6, IL-10, IFN-gamma, and P-selectin demonstrated similar correlations with survival. Heparin, Low-Molecular-Weight 25-29 interleukin 6 Homo sapiens 52-56 11399097-1 2001 OBJECTIVE: To characterize the effects of nimesulide (NIM) on basal and induced cyclo-oxygenase-2 (COX-2) gene expression in human synovial fibroblasts (HSF) and to define the intracellular mechanisms that mediate the changes in COX-2 expression and synthesis in response to the drug. nimesulide 42-52 interleukin 6 Homo sapiens 153-156 34677731-7 2021 Eugenol also reduced SARS-CoV-2 spike S1-induced activation of NF-kappaB and the expression of IL-6, IL-1beta and TNFalpha in human A549 lung cells. Eugenol 0-7 interleukin 6 Homo sapiens 95-99 16192836-0 2005 Effect of valproate on plasma levels of interleukin-6 in healthy male humans. Valproic Acid 10-19 interleukin 6 Homo sapiens 40-53 16192836-2 2005 The present study aimed to determine whether there is a treatment effect of valproate on plasma levels of the pro-inflammatory cytokine, interleukin (IL)-6, in healthy male humans. Valproic Acid 76-85 interleukin 6 Homo sapiens 137-155 16192836-3 2005 Plasma levels of IL-6 were measured in 10 healthy male humans before and after 7 days of treatment with 1000 mg per day of valproate (i.e. 500 mg in the morning and 500 mg in the evening). Valproic Acid 123-132 interleukin 6 Homo sapiens 17-21 16192836-9 2005 We found a significant increase in plasma levels of IL-6 after the 7 days of valproate treatment in healthy male subjects. Valproic Acid 77-86 interleukin 6 Homo sapiens 52-56 16192836-10 2005 Furthermore, there was a significant positive correlation between the changes in plasma IL-6 and blood levels of valproic acid. Valproic Acid 113-126 interleukin 6 Homo sapiens 88-92 16192836-11 2005 The findings of this study are consistent with previous studies on subjects with epilepsy, suggesting a modulating effect of valproate on the pro-inflammatory cytokine IL-6 in humans. Valproic Acid 125-134 interleukin 6 Homo sapiens 168-172 11170066-3 2001 Ultra violet-irradiated HSV1 induced the secretion of the IL-6 inducing factor(s) from MNC, whereas heat-inactivated HSV1 did not show this activity. ultra violet 0-12 interleukin 6 Homo sapiens 58-62 34115723-7 2021 The benefit of olaparib and other clinically approved PARP inhibitors has already been demonstrated in several experimental models of human diseases, such as neurodegeneration and neuroinflammation, acute hepatitis, skeletal muscle disorders, aging and acute ischemic stroke, protecting, for example, from the deterioration of the blood-brain barrier, restoring the cellular levels of NAD+, improving mitochondrial function and biogenesis and, among other effects, reducing oxidative stress and pro-inflammatory mediators, such as TNF-alpha, IL1-beta, IL-6 and VCAM1. olaparib 15-23 interleukin 6 Homo sapiens 552-556 11451200-8 2001 The production of interleukin-6, a representative cytoprotective cytokine, from glioma cells stimulated by TNF-alpha was suppressed by the combined use of actinomycin D, but not CDDP. Dactinomycin 155-168 interleukin 6 Homo sapiens 18-31 11250057-9 2001 Thus, our results demonstrate that crocidolite selectively stimulated production of IL-6 and GM-CSF in bronchoepithelial cells. Asbestos, Crocidolite 35-46 interleukin 6 Homo sapiens 84-88 16243232-8 2005 When they were pre-incubated with IL-1beta, IL-6 or OSM, N osteoblasts inhibited AGG synthesis and increased MMP-3 and -13 gene expression by chondrocytes in alginate beads in a same order of magnitude as SC osteoblasts. Alginates 158-166 interleukin 6 Homo sapiens 44-48 34900966-0 2021 Sensitive Colorimetric Detection of Interleukin-6 via Lateral Flow Assay Incorporated Silver Amplification Method. Silver 86-92 interleukin 6 Homo sapiens 36-49 16273626-12 2005 The concentrations of IL-6 and IL-8 in ciglitazone group were lower than those in inflammatory control group (P<0.05). ciglitazone 39-50 interleukin 6 Homo sapiens 22-26 16308450-4 2005 We have found, that pentazocine, SKF 10 047, dextrorphan reduce spontaneous secretion of IL-8, IL-6 and IL-10 and selectively changes synthesis of IL-4 by Jurkat human T lymphocyte cells lines. Pentazocine 20-31 interleukin 6 Homo sapiens 95-99 11216681-16 2001 The transcription inhibitor actinomycin D reduced both procollagen alpha1[I] transcription and interleukin-6 production. Dactinomycin 28-41 interleukin 6 Homo sapiens 95-108 34869089-7 2021 Meanwhile, the level of neutrophil, neutrophil/lymphocyte ratio (NLR), platelet count/lymphocyte ratio (PLR), mean platelet volume/lymphocyte ratio (MPVLR), C-reactive protein (CRP), lactic dehydrogenase (LDH), and interleukin (IL)-6 in the RMPP group was significantly higher (p < 0.01) than those in the NRMPP group. rmpp 241-245 interleukin 6 Homo sapiens 215-233 11050083-8 2001 Rac1N17 also inhibited HSF activation by l-azetidine-2-carboxylic acid, a proline analog, and heavy metals (CdCl)), suggesting that Rac1 may be linked to HSF activation by denaturation of polypeptides in response to various proteotoxic stresses. Proline 74-81 interleukin 6 Homo sapiens 23-26 16408727-5 2005 RESULTS: IL-5, IL-6 and IL-8 levels in both AR and NAR groups were significantly increased (all P < 0.01 for AR group; P < 0.05, 0.05, 0.01, respectively, for NAR group, as compared with normal group), and the levels were much higher in AR group than that in NAR group (P < 0.01, 0.05, 0.01, respectively). Argon 44-46 interleukin 6 Homo sapiens 15-19 34664926-0 2021 Photoelectrochemical IL-6 Immunoassay Manufactured on Multifunctional Catecholate-Modified TiO2 Scaffolds. titanium dioxide 91-95 interleukin 6 Homo sapiens 21-25 16144911-6 2005 Serum proteins were fractionated on Sepharose 4B and the activity to elevate IL-6 production was found in the excluded fractions. Sepharose 36-45 interleukin 6 Homo sapiens 77-81 11050083-8 2001 Rac1N17 also inhibited HSF activation by l-azetidine-2-carboxylic acid, a proline analog, and heavy metals (CdCl)), suggesting that Rac1 may be linked to HSF activation by denaturation of polypeptides in response to various proteotoxic stresses. Proline 74-81 interleukin 6 Homo sapiens 154-157 34664926-5 2021 The catecholate-modified TiO2 photoelectrode is combined with a signal-off direct immunoassay to detect interleukin-6 (IL-6), a key biomarker for diagnosing and monitoring various diseases. titanium dioxide 25-29 interleukin 6 Homo sapiens 104-117 11482910-1 2001 The biosynthesis of interleukin-6 receptor (IL-6R) and gp130 in vitro was blocked using specific antisense oligonucleotides (ASO) in HepG2 liver cells and the efficacy of various ASOs was tested on the generation of IL-6-induced junB mRNA. Oligonucleotides, Antisense 125-128 interleukin 6 Homo sapiens 44-48 34664926-5 2021 The catecholate-modified TiO2 photoelectrode is combined with a signal-off direct immunoassay to detect interleukin-6 (IL-6), a key biomarker for diagnosing and monitoring various diseases. titanium dioxide 25-29 interleukin 6 Homo sapiens 119-123 34726293-9 2022 RESULTS AND DISCUSSION: After 12 weeks, the ethosuximide group showed a statistically and significantly greater reduction in the serum levels of TNF-alpha, IL-6, IL-8, faecal myeloperoxidase and faecal NGAL in comparison with the control group after the treatment. Ethosuximide 44-56 interleukin 6 Homo sapiens 156-160 11847483-1 2001 BACKGROUND: Interleukin-6 (IL-6) secretion is suppressed by glucocorticoids and stimulated by catecholamines. Catecholamines 94-108 interleukin 6 Homo sapiens 12-25 11847483-1 2001 BACKGROUND: Interleukin-6 (IL-6) secretion is suppressed by glucocorticoids and stimulated by catecholamines. Catecholamines 94-108 interleukin 6 Homo sapiens 27-31 16130848-7 2005 Immune modification using local steroids and disease-modifying antirheumatic drugs, such as hydroxychloroquine, are known to inhibit inflammatory cells and cytokines, such as interleukin-1, interleukin-6 and tumor necrosis factor, which are responsible for pain and tissue damage. Hydroxychloroquine 92-110 interleukin 6 Homo sapiens 190-203 16129923-7 2005 Moreover, we found that fluoxetine (10 microM) but not imipramine (3-10 microM) significantly inhibited the LPS-stimulated interleukin-6 (IL-6) production in these cells. Fluoxetine 24-34 interleukin 6 Homo sapiens 138-142 34605100-12 2021 Following induced inflammation, both sexes exhibited an increase in IL-6 concentrations at 24H (BL v 24H: women 0.563 (0.50) v 1.141 (0.65) pg/mL; men 0.385 (0.17) v 1.113 (0.69) pg/mL p<0.05) that returned to near baseline concentrations by 48H (BL v 48H: p>0.05). 9-(3-hydroxy-2-phosphonomethoxypropyl)guanine 101-104 interleukin 6 Homo sapiens 68-72 16000871-0 2005 15-Deoxy-delta12,14-PGJ2 inhibits IL-6-induced Stat3 phosphorylation in lymphocytes. 14-pgj2 17-24 interleukin 6 Homo sapiens 34-38 11104733-5 2000 Moreover, stimulation with PGE(2), forskolin, or dibutyryl cAMP alone increased basal IL-6 secretion in a concentration-dependent manner. Bucladesine 49-63 interleukin 6 Homo sapiens 86-90 11121687-6 2000 In addition, indomethacin reduced the production of thrombin-induced IL-6 and IL-10 (p<0.05) at physiological concentrations. Indomethacin 13-25 interleukin 6 Homo sapiens 69-73 34630655-3 2021 The results of the present study indicated that daidzein significantly inhibited the production of IL-6, but not IL-8. daidzein 48-56 interleukin 6 Homo sapiens 99-103 11121687-7 2000 Indomethacin reduced the production of LPS-induced IL-6, IL-1 beta and IL-10 (p<0.05) at the highest indomethacin concentration tested. Indomethacin 0-12 interleukin 6 Homo sapiens 51-55 11121687-9 2000 It is concluded that indomethacin may reduce the thrombin-induced inflammatory reaction by decreasing IL-6 through inhibition of PGE2 synthesis. Indomethacin 21-33 interleukin 6 Homo sapiens 102-106 11121687-10 2000 This IL-6 reduction may be relevant for the ability of indomethacin to reduce the risk of Alzheimer"s disease. Indomethacin 55-67 interleukin 6 Homo sapiens 5-9 11357999-4 2000 Both the replication of DV and the production of IL-6 and IL-8 by HUVEC after DV infection were inhibited by ribavirin, an antiviral synthetic guanosine analogue. Guanosine 143-152 interleukin 6 Homo sapiens 49-53 15705788-6 2005 Azaspirane inhibits signal transducer activator of transcription 3 (STAT3) and a PI3-K (phosphatidylinositol 3-kinase) target (Akt), but not extracellular signal-regulated kinase 1 and 2 (ERK1/2), inhibits phosphorylation triggered by IL-6, and also inhibits inhibitorkappaBalpha (IkappaBalpha) and nuclear factor kappaB (NFkappaB) p65 phosphorylation triggered by tumor necrosis factor alpha (TNF-alpha). azaspirane 0-10 interleukin 6 Homo sapiens 235-239 15705788-7 2005 Of importance, azaspirane inhibits both IL-6 and vascular endothelial growth factor (VEGF) secretion in BMSCs triggered by MM cell binding and also inhibits angiogenesis on human umbilical vein cells (HUVECs). azaspirane 15-25 interleukin 6 Homo sapiens 40-44 15826602-4 2005 Actinomcyin D markedly reduced the upregulation of IL-6 and IL-8 mRNA. actinomcyin d 0-13 interleukin 6 Homo sapiens 51-55 34630655-5 2021 To elucidate the molecular mechanisms underlying the daidzein-mediated inhibition of IL-6 production, the present study examined the effects of daidzein on the phosphorylation (activation) of NF-kappaB p65, ERK1/2 and p38 MAPK. daidzein 53-61 interleukin 6 Homo sapiens 85-89 34630655-5 2021 To elucidate the molecular mechanisms underlying the daidzein-mediated inhibition of IL-6 production, the present study examined the effects of daidzein on the phosphorylation (activation) of NF-kappaB p65, ERK1/2 and p38 MAPK. daidzein 144-152 interleukin 6 Homo sapiens 85-89 34630655-7 2021 The present study revealed that among the isoflavone derivatives examined (daidzein, genistein and glycitein), daidzein inhibited the production of IL-6, but not IL-8, by IL-1beta-stimulated synovial MH7A cells via the suppression of NF-kappaB p65 and ERK1/2 activation. daidzein 75-83 interleukin 6 Homo sapiens 148-152 10873580-6 2000 Interleukin-6-inducing activities of the active glycolipids from 1,25-dihydroxy vitamin D(3)-differentiated human monocytic leukemia cells, THP-1, were inhibited by anti-CD14 mAbs in a dose-dependent manner. 1,25-dihydroxyvitamin D 65-89 interleukin 6 Homo sapiens 0-13 34630655-7 2021 The present study revealed that among the isoflavone derivatives examined (daidzein, genistein and glycitein), daidzein inhibited the production of IL-6, but not IL-8, by IL-1beta-stimulated synovial MH7A cells via the suppression of NF-kappaB p65 and ERK1/2 activation. daidzein 111-119 interleukin 6 Homo sapiens 148-152 15862962-7 2005 2-MeOEMATE reduced basal aromatase activity in TFs by 87% and completely abrogated the ability of PGE(2), IL-6 plus SR or TNFalpha to stimulate aromatase activity in these fibroblasts. 2-methoxyoestrone-3-O-sulphamate 0-10 interleukin 6 Homo sapiens 106-110 34630655-8 2021 Collectively, these results suggested that daidzein may have potential as a therapeutic agent for the treatment of arthritic disorders through its anti-inflammatory effects via the inhibition of IL-6 production. daidzein 43-51 interleukin 6 Homo sapiens 195-199 10886221-3 2000 A strong inhibition of IL-6 activity evaluated by quantification of C-reactive protein was observed in all patients and was correlated with the high CR rate achieved with this combination therapy. Chromium 149-151 interleukin 6 Homo sapiens 23-27 34754315-10 2021 Molecular docking results showed that quercetin, luteolin, kaempferol, tanshinone IIa, wogonin, naringenin, nobiletin, dihydrotanshinlactone, beta-sitosterol, and salviolone have good affinity with core target proteins IL6, PTGS2, MAPK1, MAPK3, and CGRP1. nobiletin 108-117 interleukin 6 Homo sapiens 219-222 15655130-7 2005 Treatment with irbesartan and/or lipoic acid was associated with statistically significant reductions in plasma levels of interleukin-6 and plasminogen activator-1. Thioctic Acid 33-44 interleukin 6 Homo sapiens 122-135 34768536-5 2021 We found a statistically significant trend for increasing EEV, MEV, IL-6, from group A to D, and a significant correlation between EEV and IL-6. CHEMBL4216801 131-134 interleukin 6 Homo sapiens 139-143 15678256-6 2005 In addition, ALA supplementation resulted in a significant decrease in the serum concentration of serum amyloid A (SAA) (p=0.014), C-reactive protein (CRP) (p=0.013), macrophage colony-stimulating factor (MCSF) (p<0.001), and interleukin (IL)-6 (p=0.028). alpha-Linolenic Acid 13-16 interleukin 6 Homo sapiens 229-247 16164036-7 2005 The PKC inhibitor Dequalinium chloride (DECA) remarkably reduced the production of IL-6, NF-kappaB and the activity of PKC induced by the piliated S. typhi. decabromobiphenyl ether 40-44 interleukin 6 Homo sapiens 83-87 10749745-4 2000 BEAS-2B human bronchial epithelial cells and dorsal root ganglion neurons responded to both ROFA and charged SPMs with an increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) and the release of the proinflammatory cytokine interleukin-6, whereas neutral SPMs bound with polyethylene glycol (0-mV zeta potential) were relatively ineffective. rofa 92-96 interleukin 6 Homo sapiens 231-244 34768536-6 2021 The associations between both EEV and MEV and disease severity, and between EEV and IL-6, suggest a significant interplay between pulmonary disease and inflammation, with non-respiratory cells (endothelial cells and monocytes) involvement, along with the progression of the disease. CHEMBL4216801 76-79 interleukin 6 Homo sapiens 84-88 10805370-8 2000 The enhancement of IL-6 and IL-8 production by MCG was abrogated when MCG were pretreated with the serine protease inhibitor phenylmethylsulfonyl fluoride (PMSF). Phenylmethylsulfonyl Fluoride 125-154 interleukin 6 Homo sapiens 19-23 34712133-9 2021 Concurrently, DIZE-inhibited oxidative stress and nitrosative stress via p38MAPK and NF-kappaB pathways consequently reduced release of pro-inflammatory cytokines such as TNF-alpha, IL-6, and IL-1beta. diminazene aceturate 14-18 interleukin 6 Homo sapiens 182-186 10805370-8 2000 The enhancement of IL-6 and IL-8 production by MCG was abrogated when MCG were pretreated with the serine protease inhibitor phenylmethylsulfonyl fluoride (PMSF). Phenylmethylsulfonyl Fluoride 156-160 interleukin 6 Homo sapiens 19-23 10863963-6 2000 Interestingly, these cAMP-arising reagents and the permeable cAMP analogue, dibutyryl cAMP (dbtcAMP), also increased IL-6 production by HGF. Bucladesine 76-90 interleukin 6 Homo sapiens 117-121 10863963-6 2000 Interestingly, these cAMP-arising reagents and the permeable cAMP analogue, dibutyryl cAMP (dbtcAMP), also increased IL-6 production by HGF. Bucladesine 92-99 interleukin 6 Homo sapiens 117-121 15379866-6 2004 Moreover, indomethacin was demonstrated to increase the expression of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) in a dose-dependent fashion. Indomethacin 10-22 interleukin 6 Homo sapiens 70-83 15379866-6 2004 Moreover, indomethacin was demonstrated to increase the expression of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) in a dose-dependent fashion. Indomethacin 10-22 interleukin 6 Homo sapiens 85-89 34660782-11 2021 This study revealed that SZRD has the characteristics and advantages of "multicomponent, multitarget, and multipathway" in the treatment of PDSD; among these, the combination of the main active components of quercetin and kaempferol with the key targets of AKT1, IL6, MAPK1, TP53, and VEGFA may be one of the important mechanisms. kaempferol 222-232 interleukin 6 Homo sapiens 263-266 15128598-7 2004 BZK induced rapid cell death, IL-1 release, and IL-6 secretion. Benzalkonium Compounds 0-3 interleukin 6 Homo sapiens 48-52 10743792-11 2000 IgG anti-CII positive patients (n = 40) had higher levels of TNF-alpha and IL-6 than negative patients (n = 40) (p < 0.001). N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide 9-12 interleukin 6 Homo sapiens 75-79 10743792-12 2000 Levels of IgG anti-CII correlated well with TNF-alpha (r = 0.617) and IL-6 (r = 0.347). N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide 19-22 interleukin 6 Homo sapiens 70-74 34274310-0 2021 Potential of ephedrine to suppress the gene expression of TNF-alpha, IL-1beta, IL-6 and PGE2: A novel approach towards management of rheumatoid arthritis. Ephedrine 13-22 interleukin 6 Homo sapiens 79-83 10743792-13 2000 CONCLUSION: Increased IgG anti-CII in sera and SF in RA correlated directly with acute phase reactants and the proinflammatory cytokines TNF-alpha and IL-6. N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide 31-34 interleukin 6 Homo sapiens 151-155 10693867-9 2000 Further, in RA, OSM and IL-6 levels correlated strongly with Pyr and Ag KS levels but not with D-Pyr levels, while there were no strong correlations in OA for OSM or IL-6 levels with Pyr, Ag Ks, or D-Pyr levels. Potassium 72-74 interleukin 6 Homo sapiens 24-28 15226473-5 2004 The intake of alpha-linolenic acid was inversely related to plasma concentrations of CRP (beta = -0.55, P = 0.02), Il-6 (beta = -0.36, P = 0.01), and E-selectin (beta = -0.24, P = 0.008) after controlling for age, BMI, physical activity, smoking status, alcohol consumption, and intake of linoleic acid (n-6) and saturated fat. alpha-Linolenic Acid 14-34 interleukin 6 Homo sapiens 115-119 15158360-5 2004 In combination with p65 and/or C/EBPdelta, TAM-67 also synergistically activated the IL-6 promoter, while it inhibited TNF-alpha induced AP-1 activity directing an AP-1-responsive reporter plasmid. tam-67 43-49 interleukin 6 Homo sapiens 85-89 34544857-4 2021 U-13C glucose tracing revealed that IL-6 knockout reduced 3-phosphoserine and serine production in TSC2-deficient cells, implicating IL-6 in de novo serine metabolism. Phosphoserine 58-73 interleukin 6 Homo sapiens 36-40 15024019-9 2004 Antibody neutralization experiments reveal that IL-6 is responsible for the LPA-induced mitogenic signaling and growth of the LNCaP cells. lysophosphatidic acid 76-79 interleukin 6 Homo sapiens 48-52 34566947-12 2021 Protease allergen of nTyr-p3 significantly increased the levels of pro-inflammatory cytokines (IL-6 and TNF-alpha), chemokine (IL-8), and IL-1beta in epithelial cells. ntyr-p3 21-28 interleukin 6 Homo sapiens 95-99 14751542-1 2004 In this study, we examined the signal transduction of dibutyryl cyclic adenosine monophosphate (dBcAMP) to stimulate the release of nitric oxide (NO) and interleukin-6 (IL-6) from J774 macrophages. Bucladesine 54-94 interleukin 6 Homo sapiens 154-167 10603404-9 2000 In contrast to the response to LPS, where TNF-alpha, IL-1beta, IL-6, and IL-8 appear almost simultaneously, the human monocyte response to GBS results in the production of TNF-alpha but delayed appearance of IL-1beta, IL-6, and IL-8. gbs 139-142 interleukin 6 Homo sapiens 218-222 10616000-7 1999 Tau-Cl, but not Tau, inhibited cytokine-triggered synthesis of IL-6 (50% inhibitory concentration [IC50] approximately 225 microM) and IL-8 (IC50 approximately 450 microM) when added simultaneously with the stimuli. tau-cl 0-6 interleukin 6 Homo sapiens 63-67 14751542-1 2004 In this study, we examined the signal transduction of dibutyryl cyclic adenosine monophosphate (dBcAMP) to stimulate the release of nitric oxide (NO) and interleukin-6 (IL-6) from J774 macrophages. Bucladesine 54-94 interleukin 6 Homo sapiens 169-173 34486793-10 2022 Treatment with oXiris membrane provides significant reduction of Il-6, leads to improvement in respiratory status, chest X-ray severity score, and reduction of SOFA score severity. oxiris 15-21 interleukin 6 Homo sapiens 65-69 14751542-1 2004 In this study, we examined the signal transduction of dibutyryl cyclic adenosine monophosphate (dBcAMP) to stimulate the release of nitric oxide (NO) and interleukin-6 (IL-6) from J774 macrophages. Bucladesine 96-102 interleukin 6 Homo sapiens 154-167 14751542-1 2004 In this study, we examined the signal transduction of dibutyryl cyclic adenosine monophosphate (dBcAMP) to stimulate the release of nitric oxide (NO) and interleukin-6 (IL-6) from J774 macrophages. Bucladesine 96-102 interleukin 6 Homo sapiens 169-173 15051033-4 2004 RESULTS: Secretion (mean +/- standard error) of IL-6 was, for control conditions, 1.92 +/- 0.28 fmol/mg wet weight per 3 hours; for PGE(2), 3.57 +/- 0.29 fmol/mg wet weight per 3 hours, P <.01; and for carbacyclin, 3.11 +/- 0.44 fmol/mg wet weight per 3 hours, P <.01. carboprostacyclin 205-216 interleukin 6 Homo sapiens 48-52 10616000-9 1999 In the cells prestimulated with IL-1beta for 24 hours, Tau-Cl still inhibited synthesis of IL-6, but did not affect IL-8 production. tau-cl 55-61 interleukin 6 Homo sapiens 91-95 10602388-4 1999 Dose-response experiments showed a maximal release of IL-6 and IL-8 at a concentration of 5 mM NaF 24 h after addition. Sodium Fluoride 95-98 interleukin 6 Homo sapiens 54-58 10602388-6 1999 Time-course experiments showed a NaF-induced IL-6 response at 5 h, whereas an IL-8 response was observed after 10 h. Cycloheximide treatment completely abolished the NaF-induced cytokine responses. Sodium Fluoride 33-36 interleukin 6 Homo sapiens 45-49 10602388-6 1999 Time-course experiments showed a NaF-induced IL-6 response at 5 h, whereas an IL-8 response was observed after 10 h. Cycloheximide treatment completely abolished the NaF-induced cytokine responses. Sodium Fluoride 166-169 interleukin 6 Homo sapiens 45-49 10602388-7 1999 A marked increase in the mRNA level for IL-6 was observed already 2 h after exposure to 5 mM NaF, and presumably is a prerequisite for the subsequent increase of IL-6. Sodium Fluoride 93-96 interleukin 6 Homo sapiens 40-44 10602388-7 1999 A marked increase in the mRNA level for IL-6 was observed already 2 h after exposure to 5 mM NaF, and presumably is a prerequisite for the subsequent increase of IL-6. Sodium Fluoride 93-96 interleukin 6 Homo sapiens 162-166 34479552-11 2021 CONCLUSIONS: Luteoklin, quercetin, kaempferol and other active compounds in Epicedium can regulate multiple signaling pathways and targets such as IL6, AKT1, and EGF, therefore playing therapeutic roles in depression. kaempferol 35-45 interleukin 6 Homo sapiens 147-150 14670967-2 2004 In the current study, we demonstrated that LPA is a potent inducer of interleukin-6 (IL-6) and interleukin-8 (IL-8) production in ovarian cancer cells. lysophosphatidic acid 43-46 interleukin 6 Homo sapiens 70-83 34347896-8 2021 SERPINBs was positively correlated to IL-6 and TNF-alpha in peri-implantitis patients with PICF. serpinbs 0-8 interleukin 6 Homo sapiens 38-42 14670967-2 2004 In the current study, we demonstrated that LPA is a potent inducer of interleukin-6 (IL-6) and interleukin-8 (IL-8) production in ovarian cancer cells. lysophosphatidic acid 43-46 interleukin 6 Homo sapiens 85-89 14670967-8 2004 Further, the effect of LPA on IL-6 and IL-8 generation is mediated by the Edg LPA receptors as enforced expression of LPA receptors restored LPA-induced IL-6 and IL-8 production in non-responsive cells and enhanced the sensitivity to LPA in responsive cell lines. lysophosphatidic acid 23-26 interleukin 6 Homo sapiens 30-34 14670967-8 2004 Further, the effect of LPA on IL-6 and IL-8 generation is mediated by the Edg LPA receptors as enforced expression of LPA receptors restored LPA-induced IL-6 and IL-8 production in non-responsive cells and enhanced the sensitivity to LPA in responsive cell lines. lysophosphatidic acid 23-26 interleukin 6 Homo sapiens 153-157 14670967-8 2004 Further, the effect of LPA on IL-6 and IL-8 generation is mediated by the Edg LPA receptors as enforced expression of LPA receptors restored LPA-induced IL-6 and IL-8 production in non-responsive cells and enhanced the sensitivity to LPA in responsive cell lines. lysophosphatidic acid 78-81 interleukin 6 Homo sapiens 30-34 14670967-8 2004 Further, the effect of LPA on IL-6 and IL-8 generation is mediated by the Edg LPA receptors as enforced expression of LPA receptors restored LPA-induced IL-6 and IL-8 production in non-responsive cells and enhanced the sensitivity to LPA in responsive cell lines. lysophosphatidic acid 78-81 interleukin 6 Homo sapiens 153-157 14670967-8 2004 Further, the effect of LPA on IL-6 and IL-8 generation is mediated by the Edg LPA receptors as enforced expression of LPA receptors restored LPA-induced IL-6 and IL-8 production in non-responsive cells and enhanced the sensitivity to LPA in responsive cell lines. lysophosphatidic acid 78-81 interleukin 6 Homo sapiens 30-34 14670967-8 2004 Further, the effect of LPA on IL-6 and IL-8 generation is mediated by the Edg LPA receptors as enforced expression of LPA receptors restored LPA-induced IL-6 and IL-8 production in non-responsive cells and enhanced the sensitivity to LPA in responsive cell lines. lysophosphatidic acid 78-81 interleukin 6 Homo sapiens 153-157 14670967-10 2004 These studies elucidate the transcriptional mechanism and the Edg LPA receptors involved in LPA-induced IL-6 and IL-8 production and suggest potential strategies to restrain the expression of these cytokines in ovarian cancer. lysophosphatidic acid 66-69 interleukin 6 Homo sapiens 104-108 10504447-4 1999 The increase of activator protein-2 mRNA was detected at 30 min after stimulation and that of activator protein-2 protein was at 2 h. Their levels were lower than the control levels at 24 h. The interleukin-6-dependent induction of activator protein-2 mRNA was completely blocked by adding actinomycin D, whereas it was approximately 50% affected by cycloheximide. Dactinomycin 290-303 interleukin 6 Homo sapiens 195-208 10513810-3 1999 METHODS: Chondrocytes from human articular cartilage, cultured in agarose, were stimulated with IL-6-type cytokines. Sepharose 66-73 interleukin 6 Homo sapiens 96-100 34448990-10 2022 IL-6 is a marker of intracranial inflammation and plays a role in the pathophysiology of DCVS and DCI after SAH in preclinical animal models and clinical studies. dcvs 89-93 interleukin 6 Homo sapiens 0-4 10456872-7 1999 Interestingly, a 30-base synthetic oligonucleotide containing the palindromic motif GACGTC could stimulate expression of the IL-6 gene and production of its protein in the cells. gacgtc 84-90 interleukin 6 Homo sapiens 125-129 10467171-6 1999 Actinomycin D, cycloheximide, indomethacin, and NS-398 (COX-2 inhibitor) suppressed the production of IL-6 and PGE(2). Dactinomycin 0-13 interleukin 6 Homo sapiens 102-106 10467171-6 1999 Actinomycin D, cycloheximide, indomethacin, and NS-398 (COX-2 inhibitor) suppressed the production of IL-6 and PGE(2). Indomethacin 30-42 interleukin 6 Homo sapiens 102-106 14996410-4 2004 imipramine and venlafaxine (at the higher concentration), 5-HTP (at lower and higher concentrations) and a combination of 5-HTP and fluoxetine (both at the lower concentration) increased the production of IL-6; (2). Fluoxetine 132-142 interleukin 6 Homo sapiens 205-209 14996414-7 2004 In human peripheral blood mononuclear cells (hPBMC), 100-200 microM CQ almost completely abrogated release of both TNF-alpha and IL-6 induced by CpG ODN and LPS, whereas IL-6 release induced by EC DNA was not significantly affected by 50 microM CQ. Chloroquine 68-70 interleukin 6 Homo sapiens 129-133 34456573-0 2021 Tetrandrine Inhibits Epithelial-Mesenchymal Transition in IL-6-Induced HCT116 Human Colorectal Cancer Cells. tetrandrine 0-11 interleukin 6 Homo sapiens 58-62 14991990-0 2003 [Effect of indomethacin on expression of interleukin-6 caused by lipopolysaccharide in rheumatoid arthritic patients" synoviocyte]. Indomethacin 11-23 interleukin 6 Homo sapiens 41-54 14991990-1 2003 AIM: To study the effects of indomethacin on interleukin-6 (IL-6) expression stimulated with lipopolysaccharide (LPS) in rheumatoid arthritic patients" synoviocyte. Indomethacin 29-41 interleukin 6 Homo sapiens 45-58 14991990-1 2003 AIM: To study the effects of indomethacin on interleukin-6 (IL-6) expression stimulated with lipopolysaccharide (LPS) in rheumatoid arthritic patients" synoviocyte. Indomethacin 29-41 interleukin 6 Homo sapiens 60-64 14991990-7 2003 Indomethacin at concentrations of 1 x 10(-7)-1 x 10(-5) mol.L-1 obviously inhibited the protein secretion and mRNA expression of IL-6 in FLS cultured with the supernatant from U937 cell stimulated with LPS, and the inhibitory effects increased as the concentrations of indomethacin increased. Indomethacin 0-12 interleukin 6 Homo sapiens 129-133 14991990-7 2003 Indomethacin at concentrations of 1 x 10(-7)-1 x 10(-5) mol.L-1 obviously inhibited the protein secretion and mRNA expression of IL-6 in FLS cultured with the supernatant from U937 cell stimulated with LPS, and the inhibitory effects increased as the concentrations of indomethacin increased. Indomethacin 269-281 interleukin 6 Homo sapiens 129-133 20654553-10 1999 Chromium extract did not impair TNFalpha release significantly, but inhibited IL-6 release significantly in stimulated PBMC. Chromium 0-8 interleukin 6 Homo sapiens 78-82 14991990-8 2003 CONCLUSION: Indomethacin can inhibit the increase of IL-6 expression caused by supernatant of U937 cells stimulated with LPS in FLS. Indomethacin 12-24 interleukin 6 Homo sapiens 53-57 34456573-9 2021 Tetrandrine inhibited IL-6-induced cell migration and invasion, respectively. tetrandrine 0-11 interleukin 6 Homo sapiens 22-26 10442524-10 1999 In conclusion, budesonide and fluticasone propionate, in concentrations that probably occur in the airway lining fluid during inhalational therapy, inhibited cytokine release from human lung epithelial cells (IL-6, IL-8) and alveolar macrophages (TNF-alpha, IL-6, IL-8). Fluticasone 30-52 interleukin 6 Homo sapiens 209-213 34456573-10 2021 Tetrandrine regulates the expression of migration-related genes in IL-6-stimulated HCT116 cells. tetrandrine 0-11 interleukin 6 Homo sapiens 67-71 10442524-10 1999 In conclusion, budesonide and fluticasone propionate, in concentrations that probably occur in the airway lining fluid during inhalational therapy, inhibited cytokine release from human lung epithelial cells (IL-6, IL-8) and alveolar macrophages (TNF-alpha, IL-6, IL-8). Fluticasone 30-52 interleukin 6 Homo sapiens 258-262 34456573-11 2021 Tetrandrine significantly downregulated the expression and enzyme activity of MMP-2 in IL-6-stimulated HCT116 cells. tetrandrine 0-11 interleukin 6 Homo sapiens 87-91 10652584-6 1999 SA, as well as indomethacin (INDO), reduced the synthesis of IL-6 and -11, at both the protein and mRNA levels, in the two cell lines producing these cytokines (MDA-MB-231 and Hs578T). Indomethacin 15-27 interleukin 6 Homo sapiens 61-73 14519784-3 2003 Subsequently, endothelial cells were activated by treatment with linoleic acid (90 micro mol/L) for 6 h. Zinc chelation by TPEN increased the DNA binding activity of nuclear factor (NF)-kappaB and activator protein (AP)-1, decreased PPARgamma expression and activation as well as up-regulated interleukin (IL)-6 expression and production. N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine 123-127 interleukin 6 Homo sapiens 293-311 34456573-13 2021 Conclusion: The findings of the present study suggested that tetrandrine may inhibit EMT in IL-6-stimulated HCT116 cells; therefore, it may represent a potential drug for CRC. tetrandrine 61-72 interleukin 6 Homo sapiens 92-96 10652584-6 1999 SA, as well as indomethacin (INDO), reduced the synthesis of IL-6 and -11, at both the protein and mRNA levels, in the two cell lines producing these cytokines (MDA-MB-231 and Hs578T). Indomethacin 29-33 interleukin 6 Homo sapiens 61-73 10652584-7 1999 This latter effect seemed to be mediated by PGE2 since SA and INDO reduced PGE2 levels in MDA-MB-231 and Hs578T cells, PGE2 was not detected in MCF-7 and T-47D cells and exogenous PGE2 increased IL-6 and -11 expression by MDA-MB-231 cells. Indomethacin 62-66 interleukin 6 Homo sapiens 195-207 34353059-16 2021 Its active compounds, including quercetin and kaempferol, can exert their therapeutic effects on OA by acting on TNF, PTGS2, MMP2, IL-6, IL-1beta, and other key targets to regulate inflammation, immunity, autophagy, and endocrine-related signaling pathways. kaempferol 46-56 interleukin 6 Homo sapiens 131-135 12963019-3 2003 cDNA array analysis revealed that sodium butyrate augmented ICAM-1 mRNA expression, while it inhibited IL-6 and COX-2 expression in response to LPS stimulation. Butyric Acid 34-49 interleukin 6 Homo sapiens 103-107 34126960-2 2021 We aimed to assess if 25-hydroxyvitamin-D (25OHD) levels are associated with interleukin 6 (IL-6) levels and with disease severity and mortality in COVID-19. 25ohd 43-48 interleukin 6 Homo sapiens 77-90 12970288-10 2003 In conclusion, our data suggest that raloxifene stimulates OPG production and inhibits IL-6 production by hOB. Raloxifene Hydrochloride 37-47 interleukin 6 Homo sapiens 87-91 12953163-0 2003 HMG-CoA reductase inhibitor cerivastatin inhibits interleukin-6 expression and secretion in human adipocytes. cerivastatin 28-40 interleukin 6 Homo sapiens 50-63 10388637-9 1999 Indomethacin also reduced the release of interleukin-1beta (IL-1beta) (from 166 pg/ml to 9.8 pg/ml, p =0.04, n=5) and interleukin-6 (IL-6) (from 119 ng/ml to 57 ng/ml, p=0.028, n=6), but had no effect on monocyte chemotactic protein 1 or matrix metalloproteinase-9 secretion. Indomethacin 0-12 interleukin 6 Homo sapiens 133-137 10388637-11 1999 Indomethacin reduces the production of PGE2, IL-1beta and IL-6, suggesting that cyclo-oxygenase-2 inhibitors may control the inflammation in the aneurysm wall and potentially limit AAA growth. Indomethacin 0-12 interleukin 6 Homo sapiens 58-62 12953163-3 2003 In the current study, we investigated the effect of the HMG-CoA reductase inhibitor, cerivastatin, on the production of IL-6 from cultured human adipocytes. cerivastatin 85-97 interleukin 6 Homo sapiens 120-124 34126960-9 2021 25OHD levels inversely correlated with: i) IL-6 levels (rho - 0.284, p = 0.004); ii) the subsequent need of the ICU admission (relative risk, RR 0.99, 95% confidence interval (95%CI) 0.98-1.00, p = 0.011) regardless of age, gender, presence of at least 1 comorbidity among obesity, diabetes, arterial hypertension, creatinine, IL-6 and lactate dehydrogenase levels, neutrophil cells, lymphocytes and platelets count; iii) mortality (RR 0.97, 95%CI, 0.95-0.99, p = 0.011) regardless of age, gender, presence of diabetes, IL-6 and C-reactive protein and lactate dehydrogenase levels, neutrophil cells, lymphocytes and platelets count. 25ohd 0-5 interleukin 6 Homo sapiens 43-47 12953163-4 2003 Cerivastatin reduced both IL-6 mRNA and secretion in a dose- and time-dependent manner. cerivastatin 0-12 interleukin 6 Homo sapiens 26-30 34126960-9 2021 25OHD levels inversely correlated with: i) IL-6 levels (rho - 0.284, p = 0.004); ii) the subsequent need of the ICU admission (relative risk, RR 0.99, 95% confidence interval (95%CI) 0.98-1.00, p = 0.011) regardless of age, gender, presence of at least 1 comorbidity among obesity, diabetes, arterial hypertension, creatinine, IL-6 and lactate dehydrogenase levels, neutrophil cells, lymphocytes and platelets count; iii) mortality (RR 0.97, 95%CI, 0.95-0.99, p = 0.011) regardless of age, gender, presence of diabetes, IL-6 and C-reactive protein and lactate dehydrogenase levels, neutrophil cells, lymphocytes and platelets count. 25ohd 0-5 interleukin 6 Homo sapiens 327-331 12953163-5 2003 The inhibitory effect on IL-6 mRNA was prevented by the intermediates of the cholesterol synthesis pathway, mevalonate and geranyl-geranyl-phyrophosphate (GGPP) but not by farnesyl-pyrophosphate. Mevalonic Acid 108-118 interleukin 6 Homo sapiens 25-29 34126960-9 2021 25OHD levels inversely correlated with: i) IL-6 levels (rho - 0.284, p = 0.004); ii) the subsequent need of the ICU admission (relative risk, RR 0.99, 95% confidence interval (95%CI) 0.98-1.00, p = 0.011) regardless of age, gender, presence of at least 1 comorbidity among obesity, diabetes, arterial hypertension, creatinine, IL-6 and lactate dehydrogenase levels, neutrophil cells, lymphocytes and platelets count; iii) mortality (RR 0.97, 95%CI, 0.95-0.99, p = 0.011) regardless of age, gender, presence of diabetes, IL-6 and C-reactive protein and lactate dehydrogenase levels, neutrophil cells, lymphocytes and platelets count. 25ohd 0-5 interleukin 6 Homo sapiens 520-524 12953163-6 2003 This suggests the involvement of geranylgeranyl-modified intermediates in the effect of cerivastatin on IL-6. cerivastatin 88-100 interleukin 6 Homo sapiens 104-108 34163151-8 2021 Results: Three phytocompounds including isoorientin, lupeol, and andrographolide have shown strong interactions with the targeted protein IL-6 with least binding energies (-7.1 to -7.7 kcal/mol). homoorientin 40-51 interleukin 6 Homo sapiens 138-142 12953163-8 2003 Our data suggest that cerivastatin exerts an anti-inflammatory effect by down-regulating IL-6 levels in adipocytes, which seems to be mediated by reduced production of GGPP and interference with the NFkappaB pathway. cerivastatin 22-34 interleukin 6 Homo sapiens 89-93 12913930-2 2003 From an observation that gold sodium thiomalate (GSTM) induces monocyte-derived interleukin 6 (IL-6) and IL-10 production in vitro, a hypothesis has been proposed that gold exerts its action mainly as a selective immunostimulator rather than as a general immunosuppressant. sodium thiomalate 30-47 interleukin 6 Homo sapiens 80-93 12913930-2 2003 From an observation that gold sodium thiomalate (GSTM) induces monocyte-derived interleukin 6 (IL-6) and IL-10 production in vitro, a hypothesis has been proposed that gold exerts its action mainly as a selective immunostimulator rather than as a general immunosuppressant. sodium thiomalate 30-47 interleukin 6 Homo sapiens 95-99 34168557-13 2021 Migration of RA-FLS was inhibited and the expression of protein kinase B (AKT1), JUN, caspase 3 (CASP3), TNF receptor 1 and 2 (TNFR1 and TNFR2), interleukin-6 (IL-6), and TNF-alpha was significantly affected by kaempferol. kaempferol 211-221 interleukin 6 Homo sapiens 145-158 12594059-5 2003 Actinomycin D (a transcription inhibitor), dexamethasone, indomethacin, IL-4, and IL-13 (Th(2) type cytokines) inhibited the expression of IL-6 by BK. Dactinomycin 0-13 interleukin 6 Homo sapiens 139-143 12594059-5 2003 Actinomycin D (a transcription inhibitor), dexamethasone, indomethacin, IL-4, and IL-13 (Th(2) type cytokines) inhibited the expression of IL-6 by BK. Indomethacin 58-70 interleukin 6 Homo sapiens 139-143 34168557-13 2021 Migration of RA-FLS was inhibited and the expression of protein kinase B (AKT1), JUN, caspase 3 (CASP3), TNF receptor 1 and 2 (TNFR1 and TNFR2), interleukin-6 (IL-6), and TNF-alpha was significantly affected by kaempferol. kaempferol 211-221 interleukin 6 Homo sapiens 160-164 12540635-5 2003 Subjects with the C-174C genotype of the IL-6 gene had significantly lower energy expenditure than subjects with the G-174C or G-174G genotypes both in fasting (CC 13.68 +/- 1.98, CG 14.73 +/- 1.57, GG 14.81 +/- 2.01 kcal x kg(-1) x min(-1); P = 0.012) and during the euglycemic-hyperinsulinemic clamp (CC 15.24 +/- 2.05, CG 16.62 +/- 2.06, GG 16.66 +/- 2.50 kcal x kg(-1) x min(-1); P = 0.007). cysteinylglycine 180-182 interleukin 6 Homo sapiens 41-45 12540635-5 2003 Subjects with the C-174C genotype of the IL-6 gene had significantly lower energy expenditure than subjects with the G-174C or G-174G genotypes both in fasting (CC 13.68 +/- 1.98, CG 14.73 +/- 1.57, GG 14.81 +/- 2.01 kcal x kg(-1) x min(-1); P = 0.012) and during the euglycemic-hyperinsulinemic clamp (CC 15.24 +/- 2.05, CG 16.62 +/- 2.06, GG 16.66 +/- 2.50 kcal x kg(-1) x min(-1); P = 0.007). cysteinylglycine 322-324 interleukin 6 Homo sapiens 41-45 34168557-14 2021 Thus, this study confirmed kaempferol as the effective component of Tripterygii Radix against RA-FLS and TNF signaling pathway and its involvement in the regulation of AKT1, JUN, CASP3, TNFR1, TNFR2, IL-6, and TNF-alpha expression. kaempferol 27-37 interleukin 6 Homo sapiens 200-204 34086734-12 2021 A linear mixed statistical model showed that cobalt exposure induces increase in IL-6, CXCL8 and CCL2 production over time and whereas increase of IL-6 and a decrease of CCL2 was associated with increasing cobalt chloride concentrations. cobaltous chloride 206-221 interleukin 6 Homo sapiens 147-151 12569167-3 2003 In a trial of an FcR nonbinding humanized anti-CD3 mAb hOKT3gamma1(Ala-Ala) for treatment of patients with type 1 diabetes, we found significant increases in IL-10 and IL-5 in the serum of 63% and 72% of patients, respectively, and TNF-alpha and IL-6 levels that were lower than those previously reported following OKT3 therapy. alanylalanine 67-74 interleukin 6 Homo sapiens 246-250 34063891-8 2021 The dysregulation of chemoresistance-associated genes and the inhibition of cytokines such as IL-6 by the model polymer construct, PEG-BA, holds promise for further exploration in PC treatment. peg-ba 131-137 interleukin 6 Homo sapiens 94-98 35314903-12 2022 Also, the in vitro experiment showed that UA induced epithelial-to-mesenchymal transition (EMT) and production of IL-1, IL-6, and TGF-beta in A549 cells. Uric Acid 42-44 interleukin 6 Homo sapiens 120-124 12502991-10 2003 In patients of the PA + PCEA group in the postoperative period, production of IL-1beta, IL-6, IL-1ra, and IL-10 was significantly less elevated, while IL-2 production was significantly less suppressed. Protactinium 19-21 interleukin 6 Homo sapiens 88-92 35623502-0 2022 Synergistic induction of IL-6 production in human bronchial epithelial cells in vitro by nickel nanoparticles and lipopolysaccharide is mediated by STAT3 and C/EBPbeta. Nickel 89-95 interleukin 6 Homo sapiens 25-29 12519399-10 2003 The positive result of tetracycline hydrochloride treatment was accompanied by certain particularities in the dynamics of studied cytokines and receptors: the concentrations of IL-6, IL-1 beta, TNF-alpha dropped quicker and reached lower levels, and the concentrations of sIL-6R, IL-1RA, sTNFR1 increased faster and reached higher maximum levels in the tetracycline-treated groups. Tetracycline 23-49 interleukin 6 Homo sapiens 177-181 12519399-10 2003 The positive result of tetracycline hydrochloride treatment was accompanied by certain particularities in the dynamics of studied cytokines and receptors: the concentrations of IL-6, IL-1 beta, TNF-alpha dropped quicker and reached lower levels, and the concentrations of sIL-6R, IL-1RA, sTNFR1 increased faster and reached higher maximum levels in the tetracycline-treated groups. Tetracycline 23-35 interleukin 6 Homo sapiens 177-181 35625603-5 2022 CPFX 120 microg/mL induced overexpression of IL-33, CASP-3 and CASP-9 in all cybrids, upregulation of TGF-beta1 and SOD2 in U and J cybrids, respectively, along with decreased expression of IL-6 in J cybrids. Ciprofloxacin 0-4 interleukin 6 Homo sapiens 190-194 12556067-7 2002 When pre-exposed to Bic-PDF and Bic Hi-PDF, TNFa and IL-6 production of PMphi was not significantly different from Lac-PDF. imidazole mustard 20-23 interleukin 6 Homo sapiens 53-57 12239628-0 2002 The IL-6 receptor super-antagonist Sant7 enhances antiproliferative and apoptotic effects induced by dexamethasone and zoledronic acid on multiple myeloma cells. Zoledronic Acid 119-134 interleukin 6 Homo sapiens 4-8 12239628-3 2002 We have investigated whether the IL-6 receptor super-antagonist Sant7 might enhance the antiproliferative and apoptotic effects induced by the combination of dexamethasone (Dex) and zoledronic acid (Zln) on human MM cell lines and primary cells from MM patients. Zoledronic Acid 182-197 interleukin 6 Homo sapiens 33-37 35527664-11 2022 Additionally, through ELISA and RT-qPCR, it was uncovered that Tricin reduced the LPS-induced inflammation through regulating TNF-alpha, IL-1beta and IL-6. tricin 63-69 interleukin 6 Homo sapiens 150-154 12239628-3 2002 We have investigated whether the IL-6 receptor super-antagonist Sant7 might enhance the antiproliferative and apoptotic effects induced by the combination of dexamethasone (Dex) and zoledronic acid (Zln) on human MM cell lines and primary cells from MM patients. Zoledronic Acid 199-202 interleukin 6 Homo sapiens 33-37 12143044-6 2002 The cPLA(2) inhibitor arachidonyl fluorophosphonate (MAFP) and the COX-2 inhibitor NS-398 significantly inhibited HGF- and IL-6-induced release of AA, PG synthesis, and proliferation in SG231 cells as well as two other human cholangiocarcinoma cell lines, HuCCT1 and CC-LP-1 cells. arachidonyl fluorophosphonate 22-51 interleukin 6 Homo sapiens 123-127 35419796-10 2022 CONCLUSIONS: The IL-6 bedside test is an accurate, non-invasive bedside test with 98.6% sensitivity, 94.7% specificity, 97.3% PPV, 97.3% NPV, and 97.3% overall accuracy in detecting chorioamnionitis. DOP protocol 126-129 interleukin 6 Homo sapiens 17-21 12404674-0 2002 Effects of serotonin and catecholamine depletion on interleukin-6 activation and mood in human volunteers. Catecholamines 25-38 interleukin 6 Homo sapiens 52-65 12056853-10 2002 Reducing PGE(2) synthesis by Indomethacin [a cyclo-oxygenase (COX) -1 and -2 inhibitor] reduced IL-6 levels in all osteoarthritic Ob, whereas Naproxen (a more selective COX-2 inhbitor) reduced PGE(2) and IL-6 levels only in the high osteoarthritic group. Indomethacin 29-41 interleukin 6 Homo sapiens 96-100 35277421-0 2022 Chlorzoxazone Alleviates Experimental Autoimmune Encephalomyelitis via Inhibiting IL-6 Secretion of Dendritic Cells. Chlorzoxazone 0-13 interleukin 6 Homo sapiens 82-86 11997833-10 2002 RESULTS: Regarding the peritoneal response, laparotomy versus laparoscopy when performed with CO2 significantly increased PMN and decreased the percentage of macrophages (%MF) up to 48 h. There was a significant increase in interleukin-6, and there was a fourfold increase in MF ROS production. Carbon Dioxide 94-97 interleukin 6 Homo sapiens 224-237 11997833-12 2002 The use of air versus CO2 in laparoscopy, but not in laparotomy, resulted in an increase of peritoneal PMN and a decrease of the %MF up to 48 h. Air increased the local interleukin-6 release in both procedures and increased MF ROS production fourfold. Carbon Dioxide 22-25 interleukin 6 Homo sapiens 169-182 35277421-5 2022 In this study, we reported that chlorzoxazone could ameliorate EAE pathogenesis via inhibiting IL-6 production by DCs. Chlorzoxazone 32-45 interleukin 6 Homo sapiens 95-99 35277421-8 2022 In vitro experiments showed that chlorzoxazone treatment significantly reduced DC-derived IL-6 production. Chlorzoxazone 33-46 interleukin 6 Homo sapiens 90-94 11954986-5 2002 RESULTS: Levels of IL-6 and IL-8 significantly increased in subjects with high urine Cr concentration, but TNF-alpha levels decreased. Chromium 85-87 interleukin 6 Homo sapiens 19-23 35277421-11 2022 We showed that the effect of chlorzoxazone on inhibiting the secretion of IL-6 by DCs may be mediated via the AMP-activated protein kinase pathway. Chlorzoxazone 29-42 interleukin 6 Homo sapiens 74-78 12017180-5 2002 However, indomethacin enhanced the cytokine-stimulated IL-6 mRNA synthesis by approximately 1.7 to approximately 3.4-fold. Indomethacin 9-21 interleukin 6 Homo sapiens 55-59 35364429-7 2022 These vitamins can also modulate genes induced by DAB (IL1B, IL6, IL10, iNOS, COX2, NFkappaB, GSK3B, TNF, and APP) in SH-SY5Y cells. 3,3'-Diaminobenzidine 50-53 interleukin 6 Homo sapiens 61-64 12653178-12 2002 We have also found that n-3 fatty acids plus CoQ can decrease TNF-alpha and IL-6 in AMI which are pro-inflammatory agents. coq 45-48 interleukin 6 Homo sapiens 76-80 35233569-7 2022 Mito-MES reduced production of IL-6 by SARS-CoV-2 infected epithelial cells through its antioxidant properties (Nrf2 agonist, coenzyme Q 10 moiety) and the dTPP moiety. mito-mes 0-8 interleukin 6 Homo sapiens 31-35 35233569-7 2022 Mito-MES reduced production of IL-6 by SARS-CoV-2 infected epithelial cells through its antioxidant properties (Nrf2 agonist, coenzyme Q 10 moiety) and the dTPP moiety. DTPP 156-160 interleukin 6 Homo sapiens 31-35 11824965-11 2002 CONCLUSION: The differential effects of gold salt on cytokine production, with a marked stimulatory effect on IL- 10 and IL-6, indicate that gold salt may act as a relatively selective immunostimulator rather than as a general immunosuppressant. SODIUM ANTHRAQUINONE-1-SULFONATE 141-150 interleukin 6 Homo sapiens 121-125 11741586-0 2001 The effect of beta-carotene on the expression of interleukin-6 and heme oxygenase-1 in UV-irradiated human skin fibroblasts in vitro. beta Carotene 14-27 interleukin 6 Homo sapiens 49-62 11741586-3 2001 Herein, we further show that beta-carotene also strongly promotes the UVA induction of pro-inflammatory interleukin-6 (IL-6) in skin fibroblasts in vitro. beta Carotene 29-42 interleukin 6 Homo sapiens 104-117 35327367-9 2022 Among cytokines, the ratio between IL-10 and IL-6 was found to be strongly associated with DCV (p = 0.009). DyeCycle Violet 91-94 interleukin 6 Homo sapiens 45-49 11741586-3 2001 Herein, we further show that beta-carotene also strongly promotes the UVA induction of pro-inflammatory interleukin-6 (IL-6) in skin fibroblasts in vitro. beta Carotene 29-42 interleukin 6 Homo sapiens 119-123 11741586-4 2001 Singlet oxygen quencher sodium azide abrogated up-regulation of IL-6, and likewise also of HO-1. Sodium Azide 24-36 interleukin 6 Homo sapiens 64-68 10441905-5 1999 The levels of IL-1 alpha and IL-6 mRNA induced by mineral fiber exposure were greatest in AMs exposed to TW, crocidolite, chrysotile and RF1 in that order. Asbestos, Crocidolite 109-120 interleukin 6 Homo sapiens 29-33 35280304-6 2022 Results: Significant differences were identified in the expression levels of interferon-gamma (IFN-gamma) (P < 0.001), interleukin (IL)-6 (P = 0.008) and tumor necrosis factor-alpha (TNF-alpha) (P = 0.036) in the luminal fluid of the ES comparing between the MD and AN groups. Phenobarbital 213-220 interleukin 6 Homo sapiens 119-137 10385244-5 1999 MK-571 strongly enhanced IL-6 expression at mRNA and protein level in lipopolysaccharide (LPS) and interleukin-1 (IL-1) stimulated human monocytes giving rise to 2.0+/-0.4 (x+/-s.d.) verlukast 0-6 interleukin 6 Homo sapiens 25-29 10385244-10 1999 MK-571 mediated upregulation of IL-6 in the presence of IL-1 was partially attenuated by SB203580 and PD98059. verlukast 0-6 interleukin 6 Homo sapiens 32-36 10385244-11 1999 Electrophoretic mobility shift assays demonstrated that MK-571 did not affect the IL-1 induced DNA binding activity of Activator Protein-1 and Nuclear Factor-kappaB but rather enhanced the transactivational activity of an IL-6 promoter construct. verlukast 56-62 interleukin 6 Homo sapiens 222-226 10385244-12 1999 Finally it was shown that the MK-571 mediated effects on IL-6 secretion could not be inhibited by the LT synthesis inhibitor SB203347 or by the anti-oxidant pyrrolidine dithiocarbamate (PDTC). verlukast 30-36 interleukin 6 Homo sapiens 57-61 11484194-8 2001 Cells cultured on hydrogel and polystyrene control showed comparable expression of interleukin (IL) 6, IL-10, and transforming growth factor beta, with higher expression of tumor necrosis factor alpha as determined by reverse transcription-polymerase chain reaction. Polystyrenes 31-42 interleukin 6 Homo sapiens 83-101 11597988-4 2001 We first confirmed that antioxidant N-acetylcysteine, superoxide scavenger Tiron, and DPI suppressed Ang II-induced IL-6 expression. 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt 75-80 interleukin 6 Homo sapiens 116-120 35154692-7 2022 In this study, we found that acetate, propionate, and butyrate decreased IL-1beta-induced production of CXCL2 ex vivo and IL-8 and IL-6 in vitro significantly (p < .05). Acetates 29-36 interleukin 6 Homo sapiens 131-135 11728078-4 2001 Flurbiprofen especially affected the IL-6 levels. Flurbiprofen 0-12 interleukin 6 Homo sapiens 37-41 10416955-5 1999 IL-6 is released by a range of tissues in response to stimulation by the monocyte-derived cytokines interleukin-1 and tumor necrosis factor; by suppressing production of these cytokines, fish oil, alpha-linolenic acid, and pentoxifylline can reduce IL-6 synthesis. alpha-Linolenic Acid 197-217 interleukin 6 Homo sapiens 0-4 2554932-3 1989 In this study, we demonstrated that monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals, and to a lesser extent, hydroxyapatite crystals, increased IL-6 production by synoviocytes and monocytes in vitro. Durapatite 136-150 interleukin 6 Homo sapiens 171-175 10425885-0 1999 [Effect of naproxen sodium on serum concentrations of IL-1, IL-6, and TNF in patients with acute, purulent pharyngo-tonsillitis]. Naproxen 11-26 interleukin 6 Homo sapiens 60-64 10425885-3 1999 OBJECTIVE: Assess the effect of sodium naproxen on the serum concentration of IL-1, IL-6 and TNF in acute infectious process. Naproxen 32-47 interleukin 6 Homo sapiens 84-88 10342040-1 1999 OBJECTIVES: The aim of this study was to investigate the effects of two nonsteroidal anti-inflammatory drugs (NSAIDs), nimesulide and sodium diclofenac, on the production of proteoglycans (PG), prostaglandin E2 (PGE2) and cytokines (IL-6 and IL-8) by human articular chondrocytes in vitro. nimesulide 119-129 interleukin 6 Homo sapiens 233-237 10342040-14 1999 Furthermore, both nimesulide and diclofenac at therapeutic concentrations significantly decreased spontaneous and IL-1 beta-stimulated IL-6 production by human chondrocytes, but did not modify IL-8 production. nimesulide 18-28 interleukin 6 Homo sapiens 135-139 10342040-15 1999 CONCLUSION: From the results of this study we conclude that nimesulide and diclofenac at therapeutic concentrations are potent inhibitors of PGE2 and IL-6 production while they do not modify proteoglycan or IL-8 production. nimesulide 60-70 interleukin 6 Homo sapiens 150-154 10380161-7 1999 In the BL, NO2 exposure caused increases in polymorphonuclear neutrophils (PMNs), interleukin 6 (IL-6), IL-8, alpha1-antitrypsin, and tissue plasminogen activator, and decreases in epithelial cells. Nitrogen Dioxide 11-14 interleukin 6 Homo sapiens 82-95 10380161-7 1999 In the BL, NO2 exposure caused increases in polymorphonuclear neutrophils (PMNs), interleukin 6 (IL-6), IL-8, alpha1-antitrypsin, and tissue plasminogen activator, and decreases in epithelial cells. Nitrogen Dioxide 11-14 interleukin 6 Homo sapiens 97-101 10396075-2 1999 Indo may block production of cytokines such as Il-6 in accessory cells that are critical for B-cell growth, viability and maturation, or it may directly target B cells via PPAR-gamma receptors. Indomethacin 0-4 interleukin 6 Homo sapiens 47-51 12793958-9 1999 CONCLUSIONS: MTX in combination with prednizone decreases blood levels of IL-1 beta and IL-6 and inhibits the intensity of free radical- mediated processes in RA subjects. prednizone 37-47 interleukin 6 Homo sapiens 88-92 9882597-6 1999 BEAS-2B cells exposed to ROFA in calcium-free media failed to demonstrate increases of [Ca2+]i and showed reduced levels of cytokine transcript (i.e., IL-6, IL-8, TNFalpha) and IL-6 release, suggesting that ROFA-stimulated cytokine formation was partially dependent on extracellular calcium sources. rofa 25-29 interleukin 6 Homo sapiens 151-155 9882597-6 1999 BEAS-2B cells exposed to ROFA in calcium-free media failed to demonstrate increases of [Ca2+]i and showed reduced levels of cytokine transcript (i.e., IL-6, IL-8, TNFalpha) and IL-6 release, suggesting that ROFA-stimulated cytokine formation was partially dependent on extracellular calcium sources. rofa 25-29 interleukin 6 Homo sapiens 177-181 9788616-9 1998 The nonsteroidal antiandrogen bicalutamide (Casodex) nearly completely inhibited AR activation by IL-6. bicalutamide 30-42 interleukin 6 Homo sapiens 98-102 9788616-9 1998 The nonsteroidal antiandrogen bicalutamide (Casodex) nearly completely inhibited AR activation by IL-6. bicalutamide 44-51 interleukin 6 Homo sapiens 98-102 9788616-12 1998 Stimulation of prostate-specific antigen protein secretion by IL-6 was antagonized by bicalutamide and inhibitors of protein kinase A and mitogen-activated protein kinase signaling pathways. bicalutamide 86-98 interleukin 6 Homo sapiens 62-66 9651185-8 1998 The IL-6 response was inhibited by the metal chelator deferoxamine and the free radical scavenger N-acetyl-L-cysteine, suggesting that the activation of NF-kappaB may be mediated through reactive oxygen intermediates generated by transition metals found in ROFA. rofa 257-261 interleukin 6 Homo sapiens 4-8 9693575-7 1998 Significant levels of IL-6 were produced by cells stimulated with Escherichia coli lipopolysaccharide B5 (933 pg/ml/10(7) neutrophils) and E. coli lipopolysaccharide B12 (791 pg/ml/10(7) neutrophils) when compared with unstimulated cells (39.31 pg/ml/10(7) cells). lipopolysaccharide b5 83-104 interleukin 6 Homo sapiens 22-26 9648083-9 1998 The concentration of IL-6 in the supernatant of stimulated monocytes was highest with Glu/Bic (1023 +/- 278 pg/ml) and Amino/Bic (776 +/- 296 pg/ml) an lowest with Glu/lac pH 5.5 (46 +/- 22 pg/ml) and Glu-poly/PBS (32 +/- 13 pg/ml). Lead 210-213 interleukin 6 Homo sapiens 21-25 9648083-11 1998 Glu-poly/PBS showed a suppressive effect on IL-6 mRNA expression (ratio IL-6/beta-Actin, 0.4 +/- 0.25 vs. RPMI 1.5 +/- 3.6). Glucans 0-8 interleukin 6 Homo sapiens 44-48 9648083-11 1998 Glu-poly/PBS showed a suppressive effect on IL-6 mRNA expression (ratio IL-6/beta-Actin, 0.4 +/- 0.25 vs. RPMI 1.5 +/- 3.6). Glucans 0-8 interleukin 6 Homo sapiens 72-76 9648083-11 1998 Glu-poly/PBS showed a suppressive effect on IL-6 mRNA expression (ratio IL-6/beta-Actin, 0.4 +/- 0.25 vs. RPMI 1.5 +/- 3.6). Lead 9-12 interleukin 6 Homo sapiens 44-48 9648083-11 1998 Glu-poly/PBS showed a suppressive effect on IL-6 mRNA expression (ratio IL-6/beta-Actin, 0.4 +/- 0.25 vs. RPMI 1.5 +/- 3.6). Lead 9-12 interleukin 6 Homo sapiens 72-76 9516148-2 1998 Several cytokines, including interleukin-6 (IL-6), basic fibroblast growth factor (bFGF), and platelet-derived growth factor (PDGF) may be important for survival of KS cells. Potassium 165-167 interleukin 6 Homo sapiens 29-42 9516148-2 1998 Several cytokines, including interleukin-6 (IL-6), basic fibroblast growth factor (bFGF), and platelet-derived growth factor (PDGF) may be important for survival of KS cells. Potassium 165-167 interleukin 6 Homo sapiens 44-48 9699868-11 1998 Moreover, IL-4 and IL-6 exerted the same regulatory effects on 17beta-HSD activities when testosterone and 4-dione were used as substrates, thus strongly suggesting the expression of the type 2 17beta-HSD ZR-75-1 cells. Androstenedione 107-114 interleukin 6 Homo sapiens 19-23 9678877-8 1998 On the contrary, the different concentrations of chromium extract significantly inhibited the response to PHA stimulation, as shown by the decrease in IL-6 and sIL-2r release, and by the influence on cell viability and DNA synthesis. Chromium 49-57 interleukin 6 Homo sapiens 151-155 9917534-5 1998 The progressive decrease in cytokine concentrations was identical between the two filtration modes and most pronounced with the polyacrylonitrile membrane (reduction 77% for IL-6, 39% for TNF-alpha and 95% for IL-8 after 4 h of hemofiltration). polyacrylonitrile 128-145 interleukin 6 Homo sapiens 174-178 9218512-5 1997 Recombinant human IL-6, LIF, and OSM treatments of primary human fetal pituitary cultures (16-31 wk) increased ACTH secretion by up to 48% (P < 0.05) using doses of 1 nM, and when fetal cultures were cotreated with CRH, ACTH was induced five- to sixfold as compared to CRH alone (three- to fourfold; P = 0.01). acth 111-115 interleukin 6 Homo sapiens 18-22 9218512-5 1997 Recombinant human IL-6, LIF, and OSM treatments of primary human fetal pituitary cultures (16-31 wk) increased ACTH secretion by up to 48% (P < 0.05) using doses of 1 nM, and when fetal cultures were cotreated with CRH, ACTH was induced five- to sixfold as compared to CRH alone (three- to fourfold; P = 0.01). acth 223-227 interleukin 6 Homo sapiens 18-22 9036929-0 1997 L-ascorbic acid inhibits UVA-induced lipid peroxidation and secretion of IL-1alpha and IL-6 in cultured human keratinocytes in vitro. uva 25-28 interleukin 6 Homo sapiens 87-91 9061040-1 1997 Cytomedical therapy for human interleukin-6 transgenic mice (hIL-6 Tgm) was implemented by the intraperitoneal injection of alginate-poly(L)lysine-alginate (APA) membranes microencapsulating SK2 hybridoma cells (APA-SK2 cells) which secrete anti-hIL-6 monoclonal antibodies (SK2 mAb). Alginates 124-132 interleukin 6 Homo sapiens 30-43 9061040-1 1997 Cytomedical therapy for human interleukin-6 transgenic mice (hIL-6 Tgm) was implemented by the intraperitoneal injection of alginate-poly(L)lysine-alginate (APA) membranes microencapsulating SK2 hybridoma cells (APA-SK2 cells) which secrete anti-hIL-6 monoclonal antibodies (SK2 mAb). Alginates 124-132 interleukin 6 Homo sapiens 61-66 9309381-4 1997 Both indomethacin (5 x 10(-8)-5 x 10(-6) M) and SK&F 86002 (5 x 10(-7)-10(-5) M) markedly inhibited the IL6 release and totally inhibited resorption at all concentrations tested. Indomethacin 5-17 interleukin 6 Homo sapiens 108-111 9004165-8 1996 Vesnarinone inhibited IL-6 production and pimobendan slightly decreased IL-6 production, whereas amrinone had no significant effect on IL-6 production. pimobendan 42-52 interleukin 6 Homo sapiens 72-76 9004165-8 1996 Vesnarinone inhibited IL-6 production and pimobendan slightly decreased IL-6 production, whereas amrinone had no significant effect on IL-6 production. pimobendan 42-52 interleukin 6 Homo sapiens 72-76 8914271-0 1996 Complete 1H, 15N and 13C assignments, secondary structure, and topology of recombinant human interleukin-6. 13c 21-24 interleukin 6 Homo sapiens 93-106 8914271-1 1996 Essentially complete backbone and side-chain 1H, 15N and 13C resonance assignments for the 185-amino-acid cytokine interleukin-6 (IL-6) are presented. 13c 57-60 interleukin 6 Homo sapiens 115-128 8914271-1 1996 Essentially complete backbone and side-chain 1H, 15N and 13C resonance assignments for the 185-amino-acid cytokine interleukin-6 (IL-6) are presented. 13c 57-60 interleukin 6 Homo sapiens 130-134 8706672-0 1996 Participation of two Ser-Ser-Phe-Tyr repeats in interleukin-6 (IL-6)-binding sites of the human IL-6 receptor. phenylalanyltyrosine 29-36 interleukin 6 Homo sapiens 48-61 8706672-0 1996 Participation of two Ser-Ser-Phe-Tyr repeats in interleukin-6 (IL-6)-binding sites of the human IL-6 receptor. phenylalanyltyrosine 29-36 interleukin 6 Homo sapiens 63-67 8706672-0 1996 Participation of two Ser-Ser-Phe-Tyr repeats in interleukin-6 (IL-6)-binding sites of the human IL-6 receptor. phenylalanyltyrosine 29-36 interleukin 6 Homo sapiens 96-100 8731145-5 1996 The HA/TCP particles dried at 110 degrees C were the most biologically active, stimulating significant release of interleukin 1 beta (IL-1 beta), IL-6, tumor necrosis factor alpha, and prostaglandin E2 (PGE2), products implicated as important mediators of inflammation in diverse pathologic conditions. Durapatite 4-6 interleukin 6 Homo sapiens 146-150 11859379-8 1996 This inhibition of IL-6 expression by NDGA and indomethacin was dose responsive and also reversible with the addition of exogenous prostaglandin E(2) (PGE(2)) or leukotriene B(4) (LTB(4)). Indomethacin 47-59 interleukin 6 Homo sapiens 19-23 8686529-12 1996 The postoperative maximum of IL-6 in plasma could be due to a release of catecholamines. Catecholamines 73-87 interleukin 6 Homo sapiens 29-33 8686529-14 1996 Increased plasma catecholamine concentrations as well as a damage in the blood-brain barrier due to the surgical trauma with a spill-over of IL-6 from brain tissue into plasma could have contributed to this result. Catecholamines 17-30 interleukin 6 Homo sapiens 141-145 8548766-2 1996 In human K562 erythroleukemic cells, PGA1 induces the synthesis of a M(r) 70,000 hsp (hsp70) by cycloheximide-sensitive activation of heat shock transcription factor (HSF). prostaglandin A1 37-41 interleukin 6 Homo sapiens 134-165 8548766-2 1996 In human K562 erythroleukemic cells, PGA1 induces the synthesis of a M(r) 70,000 hsp (hsp70) by cycloheximide-sensitive activation of heat shock transcription factor (HSF). prostaglandin A1 37-41 interleukin 6 Homo sapiens 167-170 8607149-9 1996 At the time of reactions to RBCs and SDAPs that were reduced before storage, the level of IL-6 was negatively correlated (r = -0.54, p = 0.014) with the duration of storage before transfusion, and there was no correlation between the level of either IL-1 beta or IL-8 and the interval before transfusion. sdaps 37-42 interleukin 6 Homo sapiens 90-94 7595543-3 1995 Complete to nearly complete inhibition of interleukin-1 beta-induced interleukin-6 production was observed with the flavonoids genistein and quercetin, the bisindole alkaloids staurosporine and K-252a, or the tyrphostin AG879. bisindole alkaloids 156-175 interleukin 6 Homo sapiens 69-82 8597883-1 1995 We performed an open, between patients, placebo controlled study in order to evaluate the effect of the treatment with the non steroidal anti inflammatory drugs indomethacin, diclofenac and naproxen on the concentrations of the cytokines IL-1 beta and IL-6 and of the neuropeptide substance P in plasma and synovial fluid of 24 rheumatoid arthritis patients. Naproxen 190-198 interleukin 6 Homo sapiens 252-256 8565026-10 1995 Lastly, serum interleukin 6 levels declined in the HCQ group (14.3 +/- 13.5 U/mL vs 12.0 +/- 16.7 U/mL; P = 0.023) but not in the placebo group (11.3 +/- 8.8 U/mL vs 7.0 +/- 11.7 U/mL); this was coincident with a decrease in serum immunoglobulin (Ig)G (2563 +/- 1352 mg/mL vs 2307 +/- 1372 mg/dL; P = 0.032), compared with the placebo group (2733 +/- 1473 mg/dL vs 2709 +/- 1501 mg/dL). Hydroxychloroquine 51-54 interleukin 6 Homo sapiens 14-27 7611579-19 1995 The elevation of the plasma catecholamines immediately after SNP administration should also be taken into account, because an augmentation of the cAMP in various cell types has been proven to result in increased release of IL-6. Catecholamines 28-42 interleukin 6 Homo sapiens 223-227 9816008-10 1995 These results show that multilamellar vesicle muramyl tripeptide phosphatidylethanolamine administration activates monocyte cytotoxicity and cytokine production (TNF-alpha, IL-6). phosphatidylethanolamine 65-89 interleukin 6 Homo sapiens 173-177 7571025-4 1995 Liposomes containing muramyl tripeptide (MLV MTP-PE) can activate monocytes from cancer patients in vitro and in vivo, making them cytotoxic such as tumor necrosis factor-alpha (TNF-alpha) and Interleukin-6 (IL-6). muramyl tripeptide 21-39 interleukin 6 Homo sapiens 193-206 7571025-4 1995 Liposomes containing muramyl tripeptide (MLV MTP-PE) can activate monocytes from cancer patients in vitro and in vivo, making them cytotoxic such as tumor necrosis factor-alpha (TNF-alpha) and Interleukin-6 (IL-6). muramyl tripeptide 21-39 interleukin 6 Homo sapiens 208-212 7537107-2 1994 In the present study, monoclonal antibodies against human gp80 interleukin-6 receptor (IL-6R) were utilized to study the role of the IL-6R in the control of the IL-6-induced AGP synthesis in the human hepatoma Hep3B cell line. agp 174-177 interleukin 6 Homo sapiens 87-91 7930877-0 1994 A highly enhanced thrombopoietic activity by monomethoxy polyethylene glycol-modified recombinant human interleukin-6. monomethoxypolyethylene glycol 45-76 interleukin 6 Homo sapiens 104-117 7930877-2 1994 We have examined the effects of monomethoxy polyethylene glycol-modified recombinant human interleukin-6 (Peg-IL-6) on thrombopoiesis in vivo. monomethoxypolyethylene glycol 32-63 interleukin 6 Homo sapiens 91-104 7930877-2 1994 We have examined the effects of monomethoxy polyethylene glycol-modified recombinant human interleukin-6 (Peg-IL-6) on thrombopoiesis in vivo. monomethoxypolyethylene glycol 32-63 interleukin 6 Homo sapiens 110-114 7945501-9 1994 Furthermore, IL-6-ASO can prevent the IL-1-induced inhibition of cartilage PG synthesis. Oligonucleotides, Antisense 18-21 interleukin 6 Homo sapiens 13-17 8053406-0 1994 Interleukin-6 antisense deoxyoligonucleotides inhibit bone resorption by giant cells from human giant cell tumors of bone. deoxyoligonucleotides 24-45 interleukin 6 Homo sapiens 0-13 8168148-4 1994 The stimulation of haptoglobin by IL-6 was abolished in the presence of 5 micrograms/ml actinomycin D and was thus likely pretranslational. Dactinomycin 88-101 interleukin 6 Homo sapiens 34-38 8113959-0 1994 Liposomal muramyl tripeptide up-regulates interleukin-1 alpha, interleukin-1 beta, tumor necrosis factor-alpha, interleukin-6 and interleukin-8 gene expression in human monocytes. muramyl tripeptide 10-28 interleukin 6 Homo sapiens 112-125 8276883-5 1994 One such site II mutant protein (with double substitution of Gln-160 with Glu and Thr-163 with Pro) was found to be an antagonist of human IL-6. Proline 95-98 interleukin 6 Homo sapiens 139-143 8003632-4 1994 Levels of IL-6 resulting from OM and IL-1 alpha stimulation could be reduced by indomethacin (10(-6) M) and restored again by also adding PGE2. Indomethacin 80-92 interleukin 6 Homo sapiens 10-14 8190832-1 1994 Interleukin-1 (IL-1) and interleukin-6 (IL-6), and their cognate receptors, are expressed in hippocampal neurons, which are targets for corticosteroid hormones. corticosteroid hormones 136-159 interleukin 6 Homo sapiens 25-38 8190832-1 1994 Interleukin-1 (IL-1) and interleukin-6 (IL-6), and their cognate receptors, are expressed in hippocampal neurons, which are targets for corticosteroid hormones. corticosteroid hormones 136-159 interleukin 6 Homo sapiens 40-44 8393800-5 1993 Furthermore, transcription and production of IL-6 was inducible by addition of dibutyryl cAMP, but not by addition of calcium ionophores or diacylglycerol. Bucladesine 79-93 interleukin 6 Homo sapiens 45-49 8314823-7 1993 In contrast, exposure to cobalt-chromium particles was associated with a decreased release of prostaglandin E2 and interleukin-6, and it had little effect on the release of interleukin-1 and tumor necrosis factor. Chromium 32-40 interleukin 6 Homo sapiens 115-128 8097119-1 1993 The expression of receptors for interleukin-6 (IL-6) on human and rhesus monkey peripheral blood and bone marrow (BM) cells was examined by multiparameter flow cytometry after staining with biologically active, biotin-labeled human IL-6 and phycoerythrin-conjugated streptavidin. Biotin 211-217 interleukin 6 Homo sapiens 32-45 8097119-1 1993 The expression of receptors for interleukin-6 (IL-6) on human and rhesus monkey peripheral blood and bone marrow (BM) cells was examined by multiparameter flow cytometry after staining with biologically active, biotin-labeled human IL-6 and phycoerythrin-conjugated streptavidin. Biotin 211-217 interleukin 6 Homo sapiens 47-51 8097119-5 1993 The IL-6 receptors on granulocytes were only detectable after staining with high concentrations of biotin-IL-6, suggesting that most IL-6 receptors on these cells represent low-affinity sites. Biotin 99-105 interleukin 6 Homo sapiens 4-8 8097119-5 1993 The IL-6 receptors on granulocytes were only detectable after staining with high concentrations of biotin-IL-6, suggesting that most IL-6 receptors on these cells represent low-affinity sites. Biotin 99-105 interleukin 6 Homo sapiens 106-110 8097119-5 1993 The IL-6 receptors on granulocytes were only detectable after staining with high concentrations of biotin-IL-6, suggesting that most IL-6 receptors on these cells represent low-affinity sites. Biotin 99-105 interleukin 6 Homo sapiens 106-110 8097119-6 1993 In contrast, IL-6 receptors on both CD4+ and CD8+ T lymphocytes were detectable at biotin-IL-6 concentrations as low as 10 pmol/L, indicating that these cells bind IL-6 with high affinity. Biotin 83-89 interleukin 6 Homo sapiens 13-17 8097119-6 1993 In contrast, IL-6 receptors on both CD4+ and CD8+ T lymphocytes were detectable at biotin-IL-6 concentrations as low as 10 pmol/L, indicating that these cells bind IL-6 with high affinity. Biotin 83-89 interleukin 6 Homo sapiens 90-94 8097119-6 1993 In contrast, IL-6 receptors on both CD4+ and CD8+ T lymphocytes were detectable at biotin-IL-6 concentrations as low as 10 pmol/L, indicating that these cells bind IL-6 with high affinity. Biotin 83-89 interleukin 6 Homo sapiens 90-94 8514977-3 1993 In 18 patients with subacute thyroiditis (SAT) evaluated within 1-2 weeks after the onset of the disease, serum IL-6 values, as assessed by an ELISA method having a limit of detection of 25 fmol/L, ranged 139.2-543.9 fmol/L (mean +/- SE, 287.2 +/- 28.2 fmol/L). Selenium 234-236 interleukin 6 Homo sapiens 112-116 8425178-5 1993 This effect of IL-6 on ir-ET-1 secretion was inhibited by actinomycin D and cycloheximide, indicating that IL-6 stimulates de novo synthesis of ir-ET-1 at a transcriptional level. Dactinomycin 58-71 interleukin 6 Homo sapiens 15-19 8425178-5 1993 This effect of IL-6 on ir-ET-1 secretion was inhibited by actinomycin D and cycloheximide, indicating that IL-6 stimulates de novo synthesis of ir-ET-1 at a transcriptional level. Dactinomycin 58-71 interleukin 6 Homo sapiens 107-111 1450209-4 1992 In HSF labeled with [3H]cholesterol exposure to 50 mU/ml of sphingomyelinase for 60 min resulted in an increase in labeled cholesteryl ester (CE) at 6 and 24 h of postincubation. Cholesterol Esters 123-140 interleukin 6 Homo sapiens 3-6 1429735-7 1992 Retinol reduced the interleukin 6 production induced by anti-IgM and interleukin 4 after 48 h, whereas the induction of interleukin 6 and tumor necrosis factor by O-tetradecanoylphorbol-13-acetate and ionomycin was less affected. o-tetradecanoylphorbol-13-acetate 163-196 interleukin 6 Homo sapiens 120-133 1394436-13 1992 AG126 enhanced IFN-gamma, IL-1, and IL-6 production in PBM that were costimulated with the stress stimuli heat shock and phenylarsine oxide. AG 127 0-5 interleukin 6 Homo sapiens 36-40 1516259-7 1992 Here it is clearly demonstrated that the kinetics of IL-6 activity post-pristane injection parallels the kinetics of agalactosyl IgG production. pristane 72-80 interleukin 6 Homo sapiens 53-57 1632677-8 1992 When the cyclo-oxygenase inhibitor indomethacin (1 x 10(-5) M) was added to cultures, the PGE2 production was inhibited, and IL-6 production was upregulated (p less than 0.05) in arginine-depleted cultures. Indomethacin 35-47 interleukin 6 Homo sapiens 125-129 1569208-4 1992 To determine the intracellular signals generated in hypoxic or ischemic cells that trigger HSF activation, we examined the effects of glucose deprivation and the metabolic inhibitor rotenone on DNA-binding activity of HSF in cultured C2 myogenic cells grown under normoxic conditions. Rotenone 182-190 interleukin 6 Homo sapiens 218-221 1569208-8 1992 However, 2 x 10(-4) M rotenone induced DNA binding of HSF within 30 min, in association with a fall in ATP to 30% of control levels, and a fall in pHi from 7.3 to 6.9. Rotenone 22-30 interleukin 6 Homo sapiens 54-57 1548355-5 1992 Treatment of decidual cells with actinomycin D or cycloheximide abrogated the increase in IL-6 production induced by IL-1 beta. Dactinomycin 33-46 interleukin 6 Homo sapiens 90-94 1371418-4 1992 The hIL-6-mediated induction of HO mRNA was completely abrogated by simultaneous treatment of cells with actinomycin D, but not with cycloheximide, suggesting that the induction occurs at the level of transcription. Dactinomycin 105-118 interleukin 6 Homo sapiens 4-9 1955561-0 1991 Benzodiazepine anesthesia in humans modulates the interleukin-1 beta, tumor necrosis factor-alpha and interleukin-6 responses of blood monocytes. Benzodiazepines 0-14 interleukin 6 Homo sapiens 102-115 1914167-4 1991 Analytical recovery of IL-6 added to EDTA-treated plasma averaged 25% more than that added to serum. Edetic Acid 37-41 interleukin 6 Homo sapiens 23-27 1814850-2 1991 Indomethacin and Y-9223, a novel cyclo-oxygenase inhibitor, inhibited the increases in the IL-6 level in the culture medium of both mitogen-stimulated adherent cells and non-adherent cells fractionated from mononuclear cells. Indomethacin 0-12 interleukin 6 Homo sapiens 91-95 1814850-2 1991 Indomethacin and Y-9223, a novel cyclo-oxygenase inhibitor, inhibited the increases in the IL-6 level in the culture medium of both mitogen-stimulated adherent cells and non-adherent cells fractionated from mononuclear cells. tilnoprofenic acid 17-23 interleukin 6 Homo sapiens 91-95 1814850-3 1991 Northern blotting showed that the mitogen-induced increase in the expression of IL-6 mRNA was inhibited by indomethacin and Y-9223, indicating that these agents inhibit IL-6 biosynthesis. Indomethacin 107-119 interleukin 6 Homo sapiens 80-84 1814850-3 1991 Northern blotting showed that the mitogen-induced increase in the expression of IL-6 mRNA was inhibited by indomethacin and Y-9223, indicating that these agents inhibit IL-6 biosynthesis. Indomethacin 107-119 interleukin 6 Homo sapiens 169-173 1814850-3 1991 Northern blotting showed that the mitogen-induced increase in the expression of IL-6 mRNA was inhibited by indomethacin and Y-9223, indicating that these agents inhibit IL-6 biosynthesis. tilnoprofenic acid 124-130 interleukin 6 Homo sapiens 80-84 1814850-3 1991 Northern blotting showed that the mitogen-induced increase in the expression of IL-6 mRNA was inhibited by indomethacin and Y-9223, indicating that these agents inhibit IL-6 biosynthesis. tilnoprofenic acid 124-130 interleukin 6 Homo sapiens 169-173 1775266-5 1991 In comparison to polystyrole (724 +/- 34 pg/ml), IL-6 production by PBMC was significantly reduced in the presence of Cuprophan (151 +/- 45 pg/ml), Hemophan (167 +/- 6 pg/ml) and polyacrylonitrile (108 +/- 33 pg/ml). polyacrylonitrile 179-196 interleukin 6 Homo sapiens 49-53 2337412-2 1990 Utilizing classical Michaelis-Menten kinetics, apparent Km and Vmax values for HSF-PLA2 of 1.34 mM and 0.47 mumol [3H]palmitic acid released/min/mg protein were obtained using dipalmitoylphosphatidylcholine (DPPC) as the substrate, and 38.0 microM and 18.8 mumol [3H]arachidonic acid released/min/mg protein with Escherichia coli as a natural substrate. 3h]palmitic acid 115-131 interleukin 6 Homo sapiens 79-82 2335234-4 1990 In organ cultures resembling closely the in vivo system 10(6) chondrocytes incubated with 100 units of interleukin-1 beta per ml of medium led to the release of 6 X 10(3) units of IL-6 within 24 h. Chondrocytes cultured in agarose or as monolayers similarly incubated with IL-1 beta produced even higher amounts of IL-6: 70 X 10(3) units per 10(6) cells within 24 h. The induction of IL-6 synthesis by IL-1 beta was also shown at the mRNA level. Sepharose 223-230 interleukin 6 Homo sapiens 180-184 2107353-7 1990 However, when PDGF-BB or -AB was combined with IL-1 beta or IL-6, prostanoid generation by HMC was synergistically increased up to 222-fold (IL-1 beta) or 12-fold (IL-6) above the control values, with the induction of PGE2 greater than 6-keto-PGF1 alpha greater than PGF2 alpha much greater than TXB2. prostaglandin F1 243-247 interleukin 6 Homo sapiens 60-64 2295801-2 1990 IL-6 alone induced minimal incorporation of [3H]thymidine by unstimulated or Staphylococcus aureus (SA)-stimulated B cells and did not augment proliferation induced by SA and IL-2. 3h]thymidine 45-57 interleukin 6 Homo sapiens 0-4 1688564-9 1990 Further, dose-response studies showed that sodium fluoride (NaF), activator of G-binding proteins, and ouabain, inhibitor of Na+/H+ pump, increased levels of IL-6 mRNA. Sodium Fluoride 43-58 interleukin 6 Homo sapiens 158-162 33793190-4 2021 We demonstrate the ability to detect IL-6 at clinically relevant concentrations in PBS buffer (pH = 7.4) with no significant interference from the similarly sized sepsis-related biomarker procalcitonin (PCT). Lead 83-86 interleukin 6 Homo sapiens 37-41 15888106-6 2005 RESULTS: Indomethacin significantly enhanced IL-1alpha-induced IL-6 production by PDL cells, although it completely inhibited IL-1alpha-induced PGE2 production. Indomethacin 9-21 interleukin 6 Homo sapiens 63-67 8584542-5 1995 When compared to air-exposed cells, NO2 induced increases in IL-6 (23.4-fold) and IL-8 (30.9-fold) mRNA abundance. Nitrogen Dioxide 36-39 interleukin 6 Homo sapiens 61-65 8584542-6 1995 The NO2-dependent increases in mRNA expression reached a maximum between 0 and 1 h post exposure and returned to baseline levels within 24 h. IL-6 and IL-8 proteins as measured by enzyme-linked immunosorbent assays (ELISA) were also elevated in supernatants recovered from NO2-exposed BEAS-2B cells. Nitrogen Dioxide 4-7 interleukin 6 Homo sapiens 142-146 34838595-8 2022 The occupational Pb-exposed group exhibited significantly higher BLL, impaired immunological markers, characterized by a marginal lowering in lymphocyte count, lymphocyte subsets (CD3+, CD4+, CD4+/CD8+ ratio), INF-gamma and IgG levels, while CD8+, IgM, IgA, IgE, and cytokines (IL-4, IL-6, IL-10, and TNF-alpha) exhibited a trend of higher values in comparison to the control group. Lead 17-19 interleukin 6 Homo sapiens 284-288 34864233-0 2022 Fluoxetine modulates the pro-inflammatory process of IL-6, IL-1beta and TNF-alpha levels in individuals with depression: a systematic review and meta-analysis. Fluoxetine 0-10 interleukin 6 Homo sapiens 53-57 34864233-3 2022 Hence, our aim was to perform a meta-analysis and systematic review to understand the interaction of fluoxetine in the IL-1beta, IL-6 and TNF-alpha inflammatory process. Fluoxetine 101-111 interleukin 6 Homo sapiens 129-133 34864233-8 2022 In conclusion, the pooled data suggest that fluoxetine treatment improved depressive symptomatology by the modulation of pro-inflammatory process such as IL-1beta, IL-6 or TNF-alpha. Fluoxetine 44-54 interleukin 6 Homo sapiens 164-168 34981723-0 2021 Lipid Accumulation and IL-6 Production in L02 Hepatocytes Induced by Sodium Oleate: Dose and Time Dependence. osteum 69-82 interleukin 6 Homo sapiens 23-27 34981723-1 2021 To explore interleukin-6 (IL-6) production and characterize lipid accumulation in L02 hepatocytes induced by sodium oleate. osteum 109-122 interleukin 6 Homo sapiens 11-24 34981723-1 2021 To explore interleukin-6 (IL-6) production and characterize lipid accumulation in L02 hepatocytes induced by sodium oleate. osteum 109-122 interleukin 6 Homo sapiens 26-30 34930286-8 2021 Besides, the Lipo-RSV could scavenge ROS and inhibit the NF-kappaB signal and inflammasomes, thereby reducing the pro-inflammatory cytokines IL-1beta, IL-6, and TNF-alpha. lipo-rsv 13-21 interleukin 6 Homo sapiens 151-155 34930972-9 2021 Pre-incubation of the myotubes with IL-6 for 24 h increased oleic acid oxidation but had no effect on glucose metabolism. Oleic Acid 60-70 interleukin 6 Homo sapiens 36-40 34943044-6 2021 We found, in both RAW 264.7 cells and HaCaT cells, MAEO inhibited LPS-stimulated inflammatory mediators such as nitric oxide (NO) and prostaglandin E2 and proinflammatory cytokines, including IL-1beta and IL-6, due to the suppression of COX-2 and iNOS expression. maeo 51-55 interleukin 6 Homo sapiens 205-209 34542838-7 2021 Furthermore, LCZ696 downregulated the excessive release of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) at mRNA and protein levels. sacubitril and valsartan sodium hydrate drug combination 13-19 interleukin 6 Homo sapiens 59-72 34542838-7 2021 Furthermore, LCZ696 downregulated the excessive release of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) at mRNA and protein levels. sacubitril and valsartan sodium hydrate drug combination 13-19 interleukin 6 Homo sapiens 74-78 34687817-8 2021 In vivo pharmacodynamic research showed that TP-Lipo@DMNs significantly reduced knee joint swelling and the level of inflammatory cytokines (TNF-alpha, IL-1beta, IL-6). tp-lipo@dmns 45-57 interleukin 6 Homo sapiens 162-166 34539828-4 2021 ALA/DHLA reduce the levels of pro-inflammatory cytokines (IL-1beta, IL-6, IL-8 and IL-17), while increasing the secretion of anti-inflammatory cytokines (IL-10). Thioctic Acid 0-3 interleukin 6 Homo sapiens 68-72 34528913-4 2021 The elevation of IL-1beta and IL-6 concentrations in synovial fluid following OA induction were dose-dependently (P < 0.05) reduced by LMCP treatment. lmcp 135-139 interleukin 6 Homo sapiens 30-34 34727650-6 2021 Results: Compared with the control group and DMSO group, the expression levels of IL-1beta, IL-6, TNF-alpha in alveolar macrophages decreased significantly in the ATL-I group (P<0.05) , and the expression levels of p-NF-kappaB, the ratio of LC3-II/LC3-I also decreased significantly in the ATL-I group (P<0.05) . Dimethyl Sulfoxide 45-49 interleukin 6 Homo sapiens 92-96 34682865-0 2021 Diosmetin Induces Modulation of Igf-1 and Il-6 Levels to Alter Rictor-Akt-PKCalpha Cascade in Inhibition of Prostate Cancer. diosmetin 0-9 interleukin 6 Homo sapiens 42-46 34496043-5 2022 The inhibition of CYPs by IL-6 was implemented by a semi-mechanistic suppression model and verified against clinical data from COVID-19 patients, treated with LPV/r. lopinavir-ritonavir drug combination 159-164 interleukin 6 Homo sapiens 26-30 34496043-6 2022 Subsequently, the verified model was used to simulate the effect of various clinically observed IL-6 levels on the exposure of LPV/r and midazolam, a CYP3A model drug. lopinavir-ritonavir drug combination 127-132 interleukin 6 Homo sapiens 96-100 34496043-9 2022 Varying IL-6 levels under COVID-19 had only a marginal effect on LPV/r pharmacokinetics according to our model. lopinavir-ritonavir drug combination 65-70 interleukin 6 Homo sapiens 8-12 34391182-0 2021 OGT regulated O-GlcNacylation promotes migration and invasion by activating IL-6/STAT3 signaling in NSCLC cells. o-glcnacylation 14-29 interleukin 6 Homo sapiens 76-80 34513827-5 2021 Further, flubendazole inhibited STAT3 activation by inhibiting its phosphorylation and nuclear localization induced by interleukin-6 (IL-6). flubendazole 9-21 interleukin 6 Homo sapiens 119-132 34513827-5 2021 Further, flubendazole inhibited STAT3 activation by inhibiting its phosphorylation and nuclear localization induced by interleukin-6 (IL-6). flubendazole 9-21 interleukin 6 Homo sapiens 134-138 34483914-3 2021 Remdesivir and cyclosporine also separately reduced IL-6 production induced by HCoV-OC43 in human lung fibroblasts MRC-5 cells with EC50 values of 224 +- 53 nM and 1,292 +- 352 nM, respectively; and synergistically reduced it when combined. remdesivir 0-10 interleukin 6 Homo sapiens 52-56 34393993-5 2021 The aim of the study was to measure the level of plasma butyrate in poorly controlled T2DM and normoglycemic participants and to compare the response of peripheral blood mononuclear cells (PBMCs) to sodium butyrate treatment between the groups by measuring production of the following cytokines: tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, interferon (IFN)-gamma, IL-13, and IL-10. Butyric Acid 199-214 interleukin 6 Homo sapiens 331-349 34152720-5 2021 Our results demonstrated that treatment with baicalein protects T98G cells from H2O2-induced damage, delays cell senescence, inhibits the secretion of SASP (IL-6, IL-8, TNF-alpha, CXCL1, and MMP-1), and inhibits SASP-related pathways NF-kappaB and JAK2/STAT1. baicalein 45-54 interleukin 6 Homo sapiens 157-161 34540745-6 2021 According to the correlation analysis, miR-221-3p in serum was remarkably positively correlated with that in CSF, NIHSS score, HAMD score, IL-6 and TNF-alpha. mir-221-3p 39-49 interleukin 6 Homo sapiens 139-143 34122007-9 2021 Meanwhile, VPA reduced dMCAo-induced elevation of IL-6 at 24 h post-stroke and significantly decreased the number of CD11b-positive microglia within peri-infarct cortex at 7 days. Valproic Acid 11-14 interleukin 6 Homo sapiens 50-54 34093539-5 2021 RDV also inhibited other pro-inflammatory genes including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), IL-12, IL-1beta, and interferon-beta (IFN-beta), leading to the reduction of inflammatory factors release. remdesivir 0-3 interleukin 6 Homo sapiens 99-112 34093539-5 2021 RDV also inhibited other pro-inflammatory genes including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), IL-12, IL-1beta, and interferon-beta (IFN-beta), leading to the reduction of inflammatory factors release. remdesivir 0-3 interleukin 6 Homo sapiens 114-118 34269100-10 2021 In addition, SHR0302 decreased the expression of chemokine receptor CXCR3 on donor T cells and the secretion of cytokines or chemokines including interleukin (IL)-6, interferon gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha), CXCL10, etc. ivarmacitinib 13-20 interleukin 6 Homo sapiens 146-164 35609387-13 2022 In vitro experiments revealed that AU reduced inflammation in LPS-induced HepG2 cells by reducing the inflammatory cytokines TNF-alpha, IL-6, as well as iNOS enzyme activity levels. aucubin 35-37 interleukin 6 Homo sapiens 136-140 35532870-0 2022 MiR-99a-5p Constrains Epithelial-Mesenchymal Transition of Cervical Squamous Cell Carcinoma Via Targeting CDC25A/IL6. mir-99a-5p 0-10 interleukin 6 Homo sapiens 113-116 35532870-9 2022 These findings suggested that miR-99a-5p may play an anti-tumor role in tumor metastasis by targeting CDC25A/IL6 to hamper EMT process, which revealed a novel molecular mechanism in CSCC. mir-99a-5p 30-40 interleukin 6 Homo sapiens 109-112 35499276-10 2022 Additionally, NiSO4 triggered inflammation in HUVECs, increasing the protein and mRNA levels of IL-6 and TNF-alpha and reducing those of TGF-beta. nickel sulfate 14-19 interleukin 6 Homo sapiens 96-100 35255378-7 2022 A strong positive correlation of GSS score was noted with IL-17(r = 0.7), IL-6 (r = 0.7), IL-1b (r = 0.7), and IL-33 (r = 0.6). gss 33-36 interleukin 6 Homo sapiens 74-78 35563697-10 2022 Our multiplex ELISA data revealed that CBD and THC significantly diminished the levels of IL-6, IL-8, and tumor necrosis factor-alpha (TNF-alpha) after LPS treatment in THP-1 macrophages and HBECs. Dronabinol 47-50 interleukin 6 Homo sapiens 90-94 35067649-4 2022 We thus investigated the association between PA and circulating interleukin-6 (IL-6) and moderation of that association by sleep in a sample of women with TMD and sleep difficulties. Protactinium 45-47 interleukin 6 Homo sapiens 64-77 35067649-4 2022 We thus investigated the association between PA and circulating interleukin-6 (IL-6) and moderation of that association by sleep in a sample of women with TMD and sleep difficulties. Protactinium 45-47 interleukin 6 Homo sapiens 79-83 35067649-9 2022 Surprisingly, when sleep was poor, PA predicted greater IL-6. Protactinium 35-37 interleukin 6 Homo sapiens 56-60 35067649-10 2022 CONCLUSIONS: The potential salutary effects of PA on resting IL-6 erode when sleep is poor, underscoring the importance of considering sleep in conceptual and intervention models of TMD. Protactinium 47-49 interleukin 6 Homo sapiens 61-65 35378756-6 2022 Restricted expression of viral gRNA and sgRNA in CD169 + macrophages elicited a pro-inflammatory cytokine expression (TNFalpha, IL-6 and IL-1beta) in a RIG-I, MDA-5 and MAVS-dependent manner, which was suppressed by remdesivir pre- treatment. remdesivir 216-226 interleukin 6 Homo sapiens 128-132 35453325-4 2022 Our objective was to describe the kinetics of four biomarkers related to pro-oxidative processes (nitrite/nitrate, malondialdehyde, 8-oxo-2"-deoxyguanosine, soluble endoglin) compared to four biomarkers of antioxidant processes (the ferric reducing ability of plasma, superoxide dismutase, asymmetric dimethylarginine, mid-regional pro-adrenomedullin) and four inflammatory biomarkers (CRP, IL-6, IL-10 and neopterin). Proline 73-76 interleukin 6 Homo sapiens 391-395 35370629-5 2022 In our previous research, we used computer simulations to design the multifunctional peptide KCF18 that can bind to TNF-alpha, IL-1beta, and IL-6 based on the binding regions of receptors and proinflammatory cytokines. kcf18 93-98 interleukin 6 Homo sapiens 141-145 35370629-7 2022 Cell experiments demonstrated that KCF18 significantly reduced the binding of proinflammatory cytokines to their cognate receptors and inhibited the mRNA and protein expressions of TNF-alpha, IL-1beta, and IL-6. kcf18 35-40 interleukin 6 Homo sapiens 206-210 35104780-0 2022 The DPA-derivative 11S, 17S-dihydroxy 7,9,13,15,19 (Z,E,Z,E,Z)-docosapentaenoic acid inhibits IL-6 production by inhibiting ROS production and ERK/NF-kappaB pathway in keratinocytes HaCaT stimulated with a fine dust PM10. 11s, 17s-dihydroxy 7,9, 19-42 interleukin 6 Homo sapiens 94-98 35222804-7 2022 Intriguingly, the toxic effect of Cr(VI) upon premature senescence of L02 hepatocytes and increased levels of IL-6/FGF23 could be partially reversed by the intracellular Ca2+ chelator BAPTA-AM pretreatment. Chromium 34-36 interleukin 6 Homo sapiens 110-114 35163833-6 2022 When macrophages were stressed by lipopolysaccharides (LPS) exposure and treated by Zopolrestat, an AKR1B10 inhibitor, the LPS-induced production of IL-6, IL-1beta, and TNFalpha is significantly reduced, reinforcing the hypothesis that the pro-inflammatory expression of cytokines is AKR1B10-dependant. zopolrestat 84-95 interleukin 6 Homo sapiens 149-153 35087712-9 2022 Inflammatory cytokines IL-6 and TNF-alpha inhibit IKr and Ito repolarizing potassium currents. Potassium 75-84 interleukin 6 Homo sapiens 23-27 35522875-2 2022 PATIENTS AND METHODS: Materials and methods: in present case-control study160 (cases 86, control 74) volunteers were enrolled in this study 2.5 ml were added to EDTA tube for molecular investigation IL6 (-174), and other 2.5 ml use for measurement of fasted glucose by spectrophotometry and insulin levels as well as IL-6 level by ELISA. Edetic Acid 161-165 interleukin 6 Homo sapiens 199-202 11583705-8 2001 PMPs also induced IL-8, IL-1 beta, and interleukin-6 (IL-6) production by ECs. pmps 0-4 interleukin 6 Homo sapiens 39-52 11583705-8 2001 PMPs also induced IL-8, IL-1 beta, and interleukin-6 (IL-6) production by ECs. pmps 0-4 interleukin 6 Homo sapiens 54-58 11593916-3 2001 Our objective was to assess the effect of naproxen on the serum levels of IL-I, IL-6 and TNF in 18 patients with osteoarthritis. Naproxen 42-50 interleukin 6 Homo sapiens 80-84 11593916-7 2001 RESULTS: Serum IL-I and IL-6 levels were reduced in the group receiving naproxen, suggesting a reduction of the degenerative changes in the patients with osteoarthritis, that may prevent the progression of the disease. Naproxen 72-80 interleukin 6 Homo sapiens 24-28 11369659-9 2001 Actinomycin D and genistein blocked IL-6 production, whereas staurosporine did not, suggesting that CD44-dependent IL-6 production requires gene transcription and tyrosine kinase activity. Dactinomycin 0-13 interleukin 6 Homo sapiens 115-119 11836849-7 2001 Plasma interleukin 6 (IL 6) level showed a sharp peak 9 hours after the onset of the symptoms in TMZ group (116.9 +/- 180.2 pg/ml vs. 45.4 +/- 37.9 pg/ml) and was increased up to 30 hours after the onset of the symptoms. Trimetazidine 97-100 interleukin 6 Homo sapiens 7-20 11836849-7 2001 Plasma interleukin 6 (IL 6) level showed a sharp peak 9 hours after the onset of the symptoms in TMZ group (116.9 +/- 180.2 pg/ml vs. 45.4 +/- 37.9 pg/ml) and was increased up to 30 hours after the onset of the symptoms. Trimetazidine 97-100 interleukin 6 Homo sapiens 22-26 11352498-3 2001 We attempted to interrupt the signal transducing pathway of IL-6 with the help of antisense oligonucleotides (ASOs) designed against the IL-6R. Oligonucleotides, Antisense 110-114 interleukin 6 Homo sapiens 60-64 11007619-7 2000 In contrast to ciprofloxacin, indomethacin was not a potent inhibitor of TNF-alpha production but potentiated IL-6 production in titanium-stimulated monocytes. Indomethacin 30-42 interleukin 6 Homo sapiens 110-114 11084220-1 2000 There are some reports that catecholamines may modulate the production of monocytic cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF alpha). Catecholamines 28-42 interleukin 6 Homo sapiens 102-115 11084220-1 2000 There are some reports that catecholamines may modulate the production of monocytic cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF alpha). Catecholamines 28-42 interleukin 6 Homo sapiens 117-121 11056211-0 2000 Inhibition of interleukin-6 signaling by galiellalactone. galiellalactone 41-56 interleukin 6 Homo sapiens 14-27 11056211-1 2000 A search for inhibitors of the IL-6-mediated signal transduction in HepG2 cells using secreted alkaline phosphatase (SEAP) as reporter gene resulted in the isolation of galiellalactone (1) from fermentations of the ascomycete strain A111-95. galiellalactone 169-184 interleukin 6 Homo sapiens 31-35 11056211-2 2000 Galiellalactone inhibits the IL-6-induced SEAP expression with IC(50) values of 250-500 nM by blocking the binding of the activated Stat3 dimers to their DNA binding sites without inhibiting the tyrosine and serine phosphorylation of the Stat3 transcription factor. galiellalactone 0-15 interleukin 6 Homo sapiens 29-33 11056211-3 2000 Due to its selective activity, galiellalactone may serve as a lead compound for the development of new therapeutic agents for diseases originating from the inappropriate expression of IL-6 and as molecular tool to dissect the JAK/STAT pathways. galiellalactone 31-46 interleukin 6 Homo sapiens 184-188 10975860-0 2000 A SAF binding site in the promoter region of human gamma-fibrinogen gene functions as an IL-6 response element. Safflower Oil 2-5 interleukin 6 Homo sapiens 89-93 10903761-5 2000 Additional studies to determine the specificity of this effect showed that although CQ reduced IL-1beta and IL-6 release, secretion of RANTES was unaffected. Chloroquine 84-86 interleukin 6 Homo sapiens 108-112 10764798-1 2000 Mitogen-activated protein (MAP) kinases stimulated by phorbol 13-myristate 12-acetate (PMA) have been shown to inhibit interleukin-6-induced activation of STAT3 (Sengupta, T. K., Talbot, E. S., Scherle, P. A., and Ivashkiv, L. B. phorbol 13-myristate 12-acetate 54-85 interleukin 6 Homo sapiens 119-132 10847630-4 2000 EMSAs demonstrated that AdiNOS inhibits IL-6-induced Stat3 activation and that this inhibition is reversible in the presence of the NOS inhibitor N(G)-monomethyl-L-arginine (L-NMA). l-nma 174-179 interleukin 6 Homo sapiens 40-44 10847630-5 2000 The induction of beta-fibrinogen mRNA by IL-6, a Stat3 dependent process, is attenuated in AdiNOS-transduced cells and partially reversed by L-NMA. l-nma 141-146 interleukin 6 Homo sapiens 41-45 10781777-2 2000 Despite their lack of proven antiviral activity, macrolide antibiotics may have anti-inflammatory actions, such as inhibition of mucus secretion and production of interleukins 6 and 8 by epithelial cells. macrolide antibiotics 49-70 interleukin 6 Homo sapiens 163-183 10826501-9 2000 ET-1-stimulated IL-6 secretion was also suppressed by diphenylene iodonium (40 microM), an inhibitor of flavon-containing enzymes such as NADH/NADPH oxidase. diphenyleneiodonium 54-74 interleukin 6 Homo sapiens 16-20 10865191-3 2000 Arabinosylated lipoarabinomannan (ARA-LAM) stimulated hyporesponsiveness by reducing TNF-alpha, GM-CSF, G-CSF, IL-10, and IL-6 release similarly to LPS, but caused no changes in IL-8 secretion. lipoarabinomannan 15-32 interleukin 6 Homo sapiens 122-126 10700573-0 2000 Sodium valproate inhibits production of TNF-alpha and IL-6 and activation of NF-kappaB. Valproic Acid 0-16 interleukin 6 Homo sapiens 54-58 10700573-8 2000 VPA significantly inhibited LPS-induced production of TNF-alpha and IL-6 by THP-1 cells, whereas other AEDs did not. Valproic Acid 0-3 interleukin 6 Homo sapiens 68-72 10700573-9 2000 The findings are consistent with the idea that VPA suppresses TNF-alpha and IL-6 production via inhibition of NF-kappaB activation. Valproic Acid 47-50 interleukin 6 Homo sapiens 76-80 10769429-10 2000 D-hormone preparations (alfacalcidol, calcitriol) possess immunoregulatory effects in vitro and in vivo by inhibiting the cytokines IL-1, IL-6, TNF-alpha and particularly IL-12. alfacalcidol 24-36 interleukin 6 Homo sapiens 138-142 10657738-8 1999 Similarly, IL-6 increased the activity of CRH promoter in a dose-dependent fashion, an effect partially reversed by indomethacin. Indomethacin 116-128 interleukin 6 Homo sapiens 11-15 10588509-1 1999 Studies performed on healthy volunteers have revealed that catecholamines down-regulate the lipopolysaccharide (LPS)-induced production of tumor necrosis factor (TNF)alpha, interleukin (IL)-6, and IL-1beta. Catecholamines 59-73 interleukin 6 Homo sapiens 173-191 10588509-7 1999 Correspondingly, in blood of patients with prolonged severe sepsis, TNFalpha was reduced by 67.2% (P < 0.0001) and IL-6 was reduced by 32.9% (P < 0.0001); IL-1beta and IL-10 were not modulated by catecholamines in these patients. Catecholamines 202-216 interleukin 6 Homo sapiens 118-122 10585039-7 1999 Interleukin-1beta and interleukin-6 levels after cardiopulmonary bypass were significantly (p < 0.05) lower in the milrinone group than in the control group. Milrinone 118-127 interleukin 6 Homo sapiens 22-35 10585039-8 1999 Plasma levels of cyclic adenosine monophosphate increased significantly (p < 0.05) after the administration of milrinone and the levels correlated inversely (r = -0.55, p < 0.01) with interleukin-6 levels. Milrinone 114-123 interleukin 6 Homo sapiens 190-203 10393680-8 1999 In explants, indomethacin 10 micromol/L or mefenamic acid 10 micromol/L abolished PGE2 secretion and significantly reduced IL-1beta and IL-6 secretion. Indomethacin 13-25 interleukin 6 Homo sapiens 136-140 10456614-3 1999 Oncostatin-M- and interleukin-6-induced fibrinogen release was inhibited in a dose-dependent manner by ciprofibrate and, to lesser extent, by bezafibrate, fenofibric acid and clofibric acid. Clofibric Acid 175-189 interleukin 6 Homo sapiens 18-31 10362713-9 1999 This cytokine-induced IL-6 production was significantly suppressed by several antioxidants, including dimethyl sulfoxide (DMSO), in airway epithelial cells. Dimethyl Sulfoxide 102-120 interleukin 6 Homo sapiens 22-26 10362713-9 1999 This cytokine-induced IL-6 production was significantly suppressed by several antioxidants, including dimethyl sulfoxide (DMSO), in airway epithelial cells. Dimethyl Sulfoxide 122-126 interleukin 6 Homo sapiens 22-26 10341002-4 1999 We also evaluated the mRNA expression for IL-6 and IL-8 in ESC after C-PAF stimulation using Northern blot analysis. 1-O-hexadecyl-2-N-methylcarbamol -sn-glycerol-3-phosphocholine 69-74 interleukin 6 Homo sapiens 42-46 10198211-0 1999 S-form lipopolysaccharide (LPS), but not lipid A or R-chemo-type LPS, induces interleukin-6 production in vitamin D3-differentiated THP-1 cells. Sulfur 0-1 interleukin 6 Homo sapiens 78-91 10418979-3 1999 In vitro, both raloxifene and estrogen inhibit mammalian osteoclast differentiation and bone resorption activity, but only in the presence of IL-6. Raloxifene Hydrochloride 15-25 interleukin 6 Homo sapiens 142-146 9921985-7 1999 Both IL-6- and OM-mediated effects are inhibited by the treatment of PC-3 with an antisense oligodeoxynucleotide against gp130, the protein kinase inhibitor genistein (GNS), or the monoterpene perillic acid (PA), a posttranslational inhibitor of p21ras isoprenylation. perillic acid 208-210 interleukin 6 Homo sapiens 5-9 12793958-0 1999 Combination of methotrexate and prednizone decreases circulating concentrations of interleukin 1 beta and Interleukin 6 in patients with rheumatoid arthritis. prednizone 32-42 interleukin 6 Homo sapiens 106-119 12793958-7 1999 MTX in combination with prednizone improved patient clinical status that was accompanied by 1.96-, 1.25-, and 1.35-fold decrease in IL-1 beta, IL-6 and TBARs after 6 month treatment (p<0.001), respectively. prednizone 24-34 interleukin 6 Homo sapiens 143-147 9884428-7 1999 In the interleukin-6-positive patients without steroid therapy, serum creatinine increased significantly after 1 year (Deltas-Cr; 1.04 +/- 0.45 mg/dl) and creatinine clearance decreased significantly (DeltaCcr; -11.7 +/- 3.2 ml/min) compared to the interleukin-6-negative patients without steroid therapy. Chromium 126-128 interleukin 6 Homo sapiens 7-20 9804975-6 1998 The IL-6 induced increase in CFI gene expression was inhibited by actinomycin D indicating regulatory effects at the level of transcription. Dactinomycin 66-79 interleukin 6 Homo sapiens 4-8 9858064-4 1998 Both indomethacin and M-5011 augmented interleukin (IL)-2 production, whereas they suppressed IL-6 production both at the protein and mRNA levels. Indomethacin 5-17 interleukin 6 Homo sapiens 94-98 9788898-5 1998 ROS/RNS appear to play a variety of roles that lead to changes in expression of genes such as interleukin-6 and intercellular adhesion molecule 1. Radon 4-7 interleukin 6 Homo sapiens 94-107 9690225-9 1998 RESULTS: Compared to the control group, PBMC from uremic patients on conservative therapy and treated by CU showed a clear reduction in the cytokine release, while PMMA and PA membranes were able to normalize IL-6, IL-8 and MCP-1 protein concentration, which had been reduced by CU treatment. Nylons 173-175 interleukin 6 Homo sapiens 209-213 9651185-6 1998 ROFA stimulated a time- and dose-dependent increase in IL-6 messenger RNA (mRNA), which was preceded by the activation of nuclear proteins binding to the NF-kappaB sequence motif in the IL-6 promoter. rofa 0-4 interleukin 6 Homo sapiens 55-59 9651185-6 1998 ROFA stimulated a time- and dose-dependent increase in IL-6 messenger RNA (mRNA), which was preceded by the activation of nuclear proteins binding to the NF-kappaB sequence motif in the IL-6 promoter. rofa 0-4 interleukin 6 Homo sapiens 186-190 9625068-0 1998 A highly sensitive enzyme-amplified lanthanide luminescence immunoassay for interleukin 6. Lanthanoid Series Elements 36-46 interleukin 6 Homo sapiens 76-89 9917534-7 1998 In conclusion, the reduction in TNF-alpha, IL-6 and IL-8 was most impressive with the polyacrylonitrile membrane after 4 h of hemofiltration and was largely due to adsorption. polyacrylonitrile 86-103 interleukin 6 Homo sapiens 43-47 9449430-6 1997 The non-specific cyclooxygenase inhibitor indomethacin and BF389 only suppressed the IL-6 release by post-mortem astrocyte culture A157. Indomethacin 42-54 interleukin 6 Homo sapiens 85-89 9449430-8 1997 Addition of exogenous PGE2 prevented the inhibitory effect of indomethacin and BF389 on the IL-1beta-activated IL-6 release from A157 astrocytes and largely potentiated the IL-1-induced release of IL-6 from all astrocytes/astroglioma cells tested. Indomethacin 62-74 interleukin 6 Homo sapiens 111-115 22358879-2 1997 In this system, the transcription of hIL-6 gene under the control of PhCMV*-1 promoter composed of tetracycline operator sequences and a minimal promoter is activated by a chimeric transactivator (tTA) composed of tetracycline repressor and transactivating domain of VP16 protein of herpes simplex virus. Tetracycline 99-111 interleukin 6 Homo sapiens 37-42 9394834-9 1997 In spite of the augmented CD86 expression on DC treated with DNCB or NiCl2, these chemicals induced different responses of DC in their expression of CD54 and HLA-DR and the production of IL-6 and tumor necrosis factor (TNF)-alpha. Dinitrochlorobenzene 61-65 interleukin 6 Homo sapiens 187-191 9364409-6 1997 Production of the part anti-inflammatory cytokine IL-6, was significantly increased by therapeutic concentrations of meloxicam, as well as by indomethacin. Indomethacin 142-154 interleukin 6 Homo sapiens 50-54 9272300-0 1997 Two NSAIDs, nimesulide and naproxen, can reduce the synthesis of urokinase and IL-6 while increasing PAI-1, in human OA synovial fibroblasts. nimesulide 12-22 interleukin 6 Homo sapiens 79-83 9272300-0 1997 Two NSAIDs, nimesulide and naproxen, can reduce the synthesis of urokinase and IL-6 while increasing PAI-1, in human OA synovial fibroblasts. Naproxen 27-35 interleukin 6 Homo sapiens 79-83 9246192-6 1997 At the transcriptional level, a slight increase of IL-6 transcripts was already detectable 1 h after irradiation, with maximum levels at 2 h, and a decline to baseline levels between 8 and 24 h. Addition of the transcriptional inhibitor actinomycin D inhibited the inducibility of IL-6 mRNA by TPA and IR. Dactinomycin 237-250 interleukin 6 Homo sapiens 51-55 9246192-6 1997 At the transcriptional level, a slight increase of IL-6 transcripts was already detectable 1 h after irradiation, with maximum levels at 2 h, and a decline to baseline levels between 8 and 24 h. Addition of the transcriptional inhibitor actinomycin D inhibited the inducibility of IL-6 mRNA by TPA and IR. Dactinomycin 237-250 interleukin 6 Homo sapiens 281-285 9547608-6 1997 The addition of n-3 PUFAs in culture medium (100 ug/ml DHA or EPA) significantly reduces the production of IL-6 by unstimulated EC; or stimulated with TNF-alpha; IL-4 pg/ml); LPS or depleted PBL respectively for DHA and EPA, whereas the n-6 PUFAs (Arachidonic acid), even used at the highest concentration, was ineffective. n-6 pufas 237-246 interleukin 6 Homo sapiens 107-111 9002011-0 1997 Chloroquine and hydroxychloroquine equally affect tumor necrosis factor-alpha, interleukin 6, and interferon-gamma production by peripheral blood mononuclear cells. Chloroquine 0-11 interleukin 6 Homo sapiens 79-92 9002011-0 1997 Chloroquine and hydroxychloroquine equally affect tumor necrosis factor-alpha, interleukin 6, and interferon-gamma production by peripheral blood mononuclear cells. Hydroxychloroquine 16-34 interleukin 6 Homo sapiens 79-92 8953156-7 1996 The release of IL-2 and IL-6 by PHA-stimulated PBMC was significantly inhibited by titanium, chromium, and cobalt. Chromium 93-101 interleukin 6 Homo sapiens 24-28 8982336-0 1996 Madindoline, a novel inhibitor of IL-6 activity from Streptomyces sp. madindoline A 0-11 interleukin 6 Homo sapiens 34-38 8982336-5 1996 Madindoline A and B displayed dose-dependent inhibition of MH60 cells, an IL-6-dependent cell line, in presence of 0.1 U/ml IL-6. madindoline A 0-13 interleukin 6 Homo sapiens 74-78 8982336-5 1996 Madindoline A and B displayed dose-dependent inhibition of MH60 cells, an IL-6-dependent cell line, in presence of 0.1 U/ml IL-6. madindoline A 0-13 interleukin 6 Homo sapiens 124-128 8831717-2 1996 Rooperol derivatives inhibited the production of tumour necrosis factor-alpha, interleukin-1 beta and interleukin-6. rooperol 0-8 interleukin 6 Homo sapiens 102-115 8937133-1 1996 UNLABELLED: To investigate the effects of disease modifying antirheumatic drugs (DMARDs) and DEX on production of IL-1 beta, IL-6 and TNF-alpha, synovial cells were observed after IL-1 beta administration in vitro. Dextromethorphan 93-96 interleukin 6 Homo sapiens 125-129 8937133-6 1996 RESULTS: DEX inhibited the production of IL-6. Dextromethorphan 9-12 interleukin 6 Homo sapiens 41-45 8932980-4 1996 The non-metabolizable CPAF was less effective than ET-18-OCH3 and showed the greatest release of IL-6 at the dose of 1 microgram/ml. 1-O-hexadecyl-2-N-methylcarbamol -sn-glycerol-3-phosphocholine 22-26 interleukin 6 Homo sapiens 97-101 8699063-4 1996 GBS III-PS, GB-Ag, and LTA each induced IL-6. gb-ag 12-17 interleukin 6 Homo sapiens 40-44 8699063-5 1996 However, IL-6 release by monocytes was significantly greater after stimulation by GB-Ag than by III-PS or LTA (P < .05). gb-ag 82-87 interleukin 6 Homo sapiens 9-13 8699063-7 1996 GB-Ag is a potent inducer of IL-6 and may play an important role in tissue inflammation during GBS infection. gb-ag 0-5 interleukin 6 Homo sapiens 29-33 8841895-8 1996 Moreover, inclusion of indomethacin caused a 20% reduction in IL-6 production and totally eliminated PGE2 production. Indomethacin 23-35 interleukin 6 Homo sapiens 62-66 8631918-4 1996 In the current study, we demonstrate that the rapid and transient stimulation of interleukin-6 and leukemia inhibitory factor is inhibited by actinomycin D and superinduced by protein synthesis inhibitors, the classical characteristics of an immediate-early gene response. Dactinomycin 142-155 interleukin 6 Homo sapiens 81-94 8625699-4 1996 Flurbiprofen may have reduced interleukin-6 secretion by the tumor, leading to a delayed diagnosis. Flurbiprofen 0-12 interleukin 6 Homo sapiens 30-43 8817534-4 1996 Tenidap, naproxen and meloxicam inhibited the IL-1 beta-induced synthesis of IL-6, whereas ibuprofen, piroxicam, diclofenac and indomethacin had no effect. Naproxen 9-17 interleukin 6 Homo sapiens 77-81 8549666-0 1996 Reversible G1 arrest induced by dimethyl sulfoxide in human lymphoid cell lines: dimethyl sulfoxide inhibits IL-6-induced differentiation of SKW6-CL4 into IgM-secreting plasma cells. Dimethyl Sulfoxide 81-99 interleukin 6 Homo sapiens 109-113 8549666-3 1996 As in the case of Raji, Akata, and Molt-4, the proliferation of SKW6-CL4 was reversibly arrested at the G1 phase by treatment with 2% DMSO for 5 days even in the presence of interleukin-6 (IL-6). Dimethyl Sulfoxide 134-138 interleukin 6 Homo sapiens 174-187 8549666-3 1996 As in the case of Raji, Akata, and Molt-4, the proliferation of SKW6-CL4 was reversibly arrested at the G1 phase by treatment with 2% DMSO for 5 days even in the presence of interleukin-6 (IL-6). Dimethyl Sulfoxide 134-138 interleukin 6 Homo sapiens 189-193 8549666-4 1996 DMSO inhibited spontaneous IgM secretion as well as IL-6-induced IgM production in SKW6-CL4 at a concentration lower than that affecting cell proliferation. Dimethyl Sulfoxide 0-4 interleukin 6 Homo sapiens 52-56 8549666-7 1996 These results indicate that DMSO not only arrests the cell cycle of a human lymphoid cell line SKW6-CL4 at the G1 phase but also inhibits the differentiation into IgM-secreting cells at a concentration lower than that affecting cell proliferation and that DMSO overcomes the effect of IL-6 on terminal differentiation of SKW6-CL4. Dimethyl Sulfoxide 28-32 interleukin 6 Homo sapiens 285-289 8845594-5 1996 Catecholamines also reduced cell proliferation, increased tartrate-resistant acid phosphatase (TRAcP) activity, interleukin 6 (IL-6) production, multi-nuclearity and response to salmon calcitonin (sCT) in undifferentiated FLG 29.1 cells. Catecholamines 0-14 interleukin 6 Homo sapiens 112-125 8845594-5 1996 Catecholamines also reduced cell proliferation, increased tartrate-resistant acid phosphatase (TRAcP) activity, interleukin 6 (IL-6) production, multi-nuclearity and response to salmon calcitonin (sCT) in undifferentiated FLG 29.1 cells. Catecholamines 0-14 interleukin 6 Homo sapiens 127-131 8845594-6 1996 In differentiated FLG 29.1 cells only IL-6 release was induced by catecholamine treatment. Catecholamines 66-79 interleukin 6 Homo sapiens 38-42 8587236-7 1995 Treatment of MC with the cycloxygenase inhibitor indomethacin resulted in partial inhibition (37%) of IL-6 production but had no effect on IL-8 generation. Indomethacin 49-61 interleukin 6 Homo sapiens 102-106 7490793-1 1995 This study aimed to assess the possibility of a direct effect of betel-nut alkaloids arecoline and arecaidine on cell proliferation and interleukin-6 (IL-6) production by cultured fibroblasts from human normal gingiva, buccal mucosa and oral submucous fibrosis (OSF) buccal mucosa in vitro. Arecoline 85-94 interleukin 6 Homo sapiens 136-149 7490793-9 1995 However, two of six individuals" normal buccal mucosa fibroblasts significantly released less IL-6, and some cases of OSF and healthy gingiva exhibited slightly higher levels of IL-6 when cells were exposed to arecoline or arecaidine in cultures. Arecoline 210-219 interleukin 6 Homo sapiens 178-182 7490793-10 1995 Such findings suggests that arecoline and arecaidine can enhance cell proliferation and affect fibroblasts to synthesize IL-6. Arecoline 28-37 interleukin 6 Homo sapiens 121-125 7575694-8 1995 Significant reductions in plasma IL-6 levels were observed at weeks 4, 12, and 24 within the tenidap group, and at week 24 within the hydroxychloroquine-plus-piroxicam-treated group. Hydroxychloroquine 134-152 interleukin 6 Homo sapiens 33-37 7668562-0 1995 Interleukin-6 serum levels in depressed patients before and after treatment with fluoxetine. Fluoxetine 81-91 interleukin 6 Homo sapiens 0-13 8589268-7 1995 Indomethacin (IM) enhanced TNF production in all the eight TCC that were established from a patient with human T lymphotrophic virus type 1 uveitis or pulmonary sarcoidosis, and suppressed IL-6 production in six of the eight TCC, without affecting their low levels of PGE2 production. Indomethacin 0-12 interleukin 6 Homo sapiens 189-193 8589268-7 1995 Indomethacin (IM) enhanced TNF production in all the eight TCC that were established from a patient with human T lymphotrophic virus type 1 uveitis or pulmonary sarcoidosis, and suppressed IL-6 production in six of the eight TCC, without affecting their low levels of PGE2 production. Indomethacin 14-16 interleukin 6 Homo sapiens 189-193 7877083-4 1994 IL-6 secretion from either IL-1 beta- or TNF-alpha-stimulated HGF was enhanced by the inhibition of PGE2 synthesis with indomethacin. Indomethacin 120-132 interleukin 6 Homo sapiens 0-4 7927744-1 1994 Mycoplasma arginini TUH-14 partially purified membrane lipoproteins (TUH-14-pp) directly induce secretion of the cytokines involved in the inflammatory response, namely, interleukin 1 (IL-1), tumor necrosis factor alpha, and IL-6, by human monocytes cultured in the absence of serum. tuh-14 20-26 interleukin 6 Homo sapiens 225-229 7831669-5 1994 Further, PRP incubated with IL-6 showed a dose dependent increase in TXB2 and BTG secretion as measured by RIA and an increased incorporation of actin binding protein, talin, and myosin into the cytoskeletal core (triton insoluble residue) as shown by SDS-PAGE. beta-2'-deoxythioguanosine 78-81 interleukin 6 Homo sapiens 28-32 8013439-6 1994 The addition of a chelating agent, EDTA, to the cultures prevented the suppression of IL-6 secretion. Edetic Acid 35-39 interleukin 6 Homo sapiens 86-90 8161348-4 1994 IL-6 treatment of HepG2 cells increased mRNA for microsomal heme oxygenase, the rate-limiting enzyme in heme catabolism, suggesting that the suppressive effect of IL-6 on CYPIA1 mRNA may be due to a loss of heme. Heme 60-64 interleukin 6 Homo sapiens 0-4 8161348-4 1994 IL-6 treatment of HepG2 cells increased mRNA for microsomal heme oxygenase, the rate-limiting enzyme in heme catabolism, suggesting that the suppressive effect of IL-6 on CYPIA1 mRNA may be due to a loss of heme. Heme 60-64 interleukin 6 Homo sapiens 163-167 8161348-6 1994 These findings suggest that the suppression of P450IA1 mRNA by IL-6 appears to occur, at least in part, from the decline in free heme content as a result of the induction of heme oxygenase. Heme 129-133 interleukin 6 Homo sapiens 63-67 8129795-6 1994 RESULTS: Human chondrocytes in agarose culture expressed messenger RNA (mRNA) for the IL-6 receptor (gp80) and its signal-transducing subunit gp130. Sepharose 31-38 interleukin 6 Homo sapiens 86-90 8301142-9 1994 13-cis-retinoic acid, retinol, retinaldehyde, all-trans etretin, Ro 13-6298, and 9-cis retinoic acid also inhibited IL-1-induced IL-6 production. Retinaldehyde 31-44 interleukin 6 Homo sapiens 129-133 8146977-6 1994 Transfusion of PC containing high levels of IL-6 and TNF-alpha has been associated with febrile transfusion reactions in the recipient and therefore the prestorage leukocyte removal might prevent these febrile transfusion reactions. pc 15-17 interleukin 6 Homo sapiens 44-48 8244994-3 1993 In lipopolysaccharide-stimulated human whole blood, the OH radical scavenger dimethyl sulfoxide (Me2SO) dramatically inhibited (approximately 90%) IL-8 production, but had minimal effects on the production of tumor necrosis factor, interleukin 1 beta (IL-1), and IL-6. Dimethyl Sulfoxide 77-95 interleukin 6 Homo sapiens 263-267 8244453-6 1993 TNF and IL-6 production were suppressed in a dose-dependent manner when macrophages were treated with chloroquine, but not with other anti-malarial drugs. Chloroquine 102-113 interleukin 6 Homo sapiens 8-12 8244453-8 1993 Our results demonstrated that chloroquine-induced inhibition of TNF and IL-6 production is not mediated through a lysosomotropic mechanism, and that chloroquine probably acts on TNF secretion by disrupting iron homeostasis. Chloroquine 30-41 interleukin 6 Homo sapiens 72-76 8354288-5 1993 This complex was stable in SDS and 2-mercaptoethanol at 100 degrees C and was not dissociated by hydroxylamine treatment, indicating the formation of a covalent non-ester bond between the 8-kDa 125I-IL-6-derived peptide and an undetermined acceptor. Mercaptoethanol 35-52 interleukin 6 Homo sapiens 199-203 8354288-5 1993 This complex was stable in SDS and 2-mercaptoethanol at 100 degrees C and was not dissociated by hydroxylamine treatment, indicating the formation of a covalent non-ester bond between the 8-kDa 125I-IL-6-derived peptide and an undetermined acceptor. Esters 165-170 interleukin 6 Homo sapiens 199-203 8503562-0 1993 Changes in cell population and tumor necrosis factor, interleukin-6, and interleukin-8 in malignant pleural effusions after treatment with intrapleural tetracycline. Tetracycline 152-164 interleukin 6 Homo sapiens 54-67 8503562-7 1993 IL-6, IL-8, and TNF were markedly increased on Day 4 after TC intrapleural injection and then decreased to baseline levels on Day 14. Tetracycline 59-61 interleukin 6 Homo sapiens 0-4 8503562-8 1993 The results suggest that TC intrapleural injection induces the release of cytokines (IL-6 and TNF), which are markers of an inflammatory response, and releases IL-8, which attracts neutrophils into the pleural space, which may be the mechanism of the sclerosing effect of TC. Tetracycline 25-27 interleukin 6 Homo sapiens 85-97 8389732-1 1993 1,25-Dihydroxyvitamin D3 (1,25-(OH)2D3) inhibits the proliferation of mitogen-stimulated human mononuclear cells (MNC) as well as the production of a number of proinflammatory cytokines, including interleukin (IL)-1 alpha, IL-6, tumour necrosis factor-alpha, IL-2, interferon-gamma (IFNg) and lymphotoxin (LT). 1,25-dihydroxyvitamin d3 (1,25-(oh)2d3 0-38 interleukin 6 Homo sapiens 223-227 1294780-5 1992 The results were as follows: (1) The production of IL-1 beta, TNF alpha and IL-6 in TB patients was significantly higher than that observed in the healthy control subjects. Terbium 84-86 interleukin 6 Homo sapiens 76-80 1294780-6 1992 (2) The production of IL-1 beta, TNF alpha and IL-6 in TB+DM patients was significantly lower than that observed in the TB patients. Terbium 55-57 interleukin 6 Homo sapiens 47-51 1404130-2 1992 We investigated the effects of an NSAID, flurbiprofen, on production of the cytokines tumor necrosis factor alpha (TNF alpha), interleukin 1 beta (IL-1 beta) and interleukin 6 (IL-6) by human peripheral blood monocytes and by the human cell lines U-937 and THP-1. Flurbiprofen 41-53 interleukin 6 Homo sapiens 162-175 1404130-6 1992 In contrast, flurbiprofen completely abolished IL-6 production by both cell lines and substantially inhibited IL-1 beta and TNF alpha production. Flurbiprofen 13-25 interleukin 6 Homo sapiens 47-51 1389011-1 1992 We investigated the capacity of cellulose cuprophane (CUP) and synthetic polyacrylonitrile dialysis membranes to induce the production of interleukin 1 (IL-1), interleukin 6 (IL-6), and tumor necrosis factor alpha using an in vitro model in which normal whole blood is incubated directly with calibrated membrane fragments. polyacrylonitrile 73-90 interleukin 6 Homo sapiens 160-173 1594325-8 1992 Production of IL-6 protein was inhibited by actinomycin D and the IL-6 mRNA content of monocytes from neonates, as assessed by competitive polymerase chain reaction, was less than that of adult monocytes. Dactinomycin 44-57 interleukin 6 Homo sapiens 14-18 1718855-3 1991 Although MH166 completely neutralized hIL-6 activity in vitro, treatment in vivo with hIL-6 and MH166 combined unexpectedly increased both anti-dinitrophenyl (DNP) and anti-sheep red blood cell (SRBC) antibody production more than treatment with IL-6 alone did. srbc 195-199 interleukin 6 Homo sapiens 86-91 1931864-3 1991 In this study, we have examined the ability of alginates and their components to stimulate human monocytes to produce tumor necrosis factor-alpha, interleukin-6, and interleukin-1. Alginates 47-56 interleukin 6 Homo sapiens 147-160 1680274-4 1991 Using H1 receptor (cetirizin and loderix) and H2 receptor (cimetidine and ranitidine) specific antagonists, an H1-dependent stimulation of IL-6 binding by CESS cells was found. Cimetidine 59-69 interleukin 6 Homo sapiens 139-143 2012982-5 1991 Both Nal and Indo abolished the febrile rises evoked by IFN, TNF, and IL6. Naloxone 5-8 interleukin 6 Homo sapiens 70-73 2012982-5 1991 Both Nal and Indo abolished the febrile rises evoked by IFN, TNF, and IL6. Indomethacin 13-17 interleukin 6 Homo sapiens 70-73 33767774-12 2021 In addition, the TNF-alpha-induced increase in the cell proliferative and migratory rates and the production of IL-6 and IL-1beta were markedly inhibited following miR-23a-5p overexpression. mir-23a-5p 164-174 interleukin 6 Homo sapiens 112-116 33814251-9 2021 Furthermore, patients in the high IL-6 group significantly more frequently received catecholamine therapy (P = 0.005), venoarterial extracorporeal membrane oxygenation (P = 0.029), and artificial respirator support (P = 0.021) in the acute phase of myocarditis. Catecholamines 84-97 interleukin 6 Homo sapiens 34-38 26640530-13 2015 In the DEX group compared with the control group, IL-1beta, IL-6 and CRP levels were markedly decreased at 6 h and 1 day after surgery (P<0.01). Dextromethorphan 7-10 interleukin 6 Homo sapiens 60-64 25394692-11 2015 Intervention with diet plus omega-3 was associated with significant reduction in systolic (< 12.2%) and diastolic (< 8.2%) blood pressure, serum triglyceride concentration (< 21.4%), and insulin resistance (< 13.1%) (p < 0.05), as well as a reduction in serum IL-6 concentration (< 28.5%) (p = 0.034). omega-3 28-35 interleukin 6 Homo sapiens 275-279 9269788-7 1997 Compared with vehicle control, pretreatment with SDZ MRL 953 markedly reduced the release of TNF-alpha, IL-1beta, IL-8, IL-6, and G-CSF, but augmented the increase in granulocyte counts to endotoxin. Sulfadiazine 49-52 interleukin 6 Homo sapiens 120-124 34236247-9 2022 17,18-EpETE significantly inhibited tumor necrosis factor (TNF)-alpha-induced production of interleukin (IL)-6 , IL-8, and mucin from cultured human airway epithelial cells dose dependently, and these antiinflammatory effects on cytokine production were abolished by GW1100, a selective GPR40 antagonist. GW1100 267-273 interleukin 6 Homo sapiens 92-110 34801855-10 2022 Baicalein reduces the production of inflammatory mediators TNF-alpha, MIP-1, IL-6, and diminishes neutrophil influx and severity of endotoxin-mediated ALI. baicalein 0-9 interleukin 6 Homo sapiens 77-81 34981723-5 2021 With extended sodium oleate incubation time, IL-6 levels increased, and free fatty acids decreased. osteum 14-27 interleukin 6 Homo sapiens 45-49 34981723-6 2021 After 24 h incubation, IL-6 levels increased as sodium oleate increased from 37.5 to 300 mumol/L ( P < 0.05 for 37.5 mumol/L, P < 0.01 for 75 mumol/L and P < 0.001 for concentrations 150 mumol/L or higher). osteum 48-61 interleukin 6 Homo sapiens 23-27 34981723-8 2021 Oil Red O staining intensified with incubation time extending beyond 2 h. IL-6 production and lipid accumulation in L02 hepatocytes are influenced by sodium oleate in a dose- and time-dependent manner. osteum 150-163 interleukin 6 Homo sapiens 74-78 34948051-0 2021 Constitutive, Basal, and beta-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled Receptor D Induces Release of the Inflammatory Cytokine IL-6 and Is Dependent on NF-kappaB Signaling. beta-Alanine 25-37 interleukin 6 Homo sapiens 157-161 34948051-5 2021 By stimulating human MRGPRD-expressing HeLa cells with the agonist beta-alanine, we observed a release of IL-6. beta-Alanine 67-79 interleukin 6 Homo sapiens 106-110 34948051-6 2021 beta-alanine-induced signaling through MRGPRD was investigated further by probing downstream signaling effectors along the Galphaq/Phospholipase C (PLC) pathway, which results in an IkB kinases (IKK)-mediated canonical activation of nuclear factor kappa-B (NF-kappaB) and stimulation of IL-6 release. beta-Alanine 0-12 interleukin 6 Homo sapiens 287-291 34948051-9 2021 Consequently, the dynamic range for IL-6 detection as an assay for beta-alanine-mediated activation of MRGPRD is substantially increased by culturing the cells in FBS free medium before treatment. beta-Alanine 67-79 interleukin 6 Homo sapiens 36-40 34427537-6 2021 Additionally, naproxen suppressed the expression of the cytokines IL-6, IL-12, and tumor necrosis factor-alpha (TNF-alpha), and downregulated the expression of vascular endothelial growth factor (VEGF) and tissue factor (TF) induced by IL-1beta. Naproxen 14-22 interleukin 6 Homo sapiens 66-70 34506261-8 2021 Argon increased the proliferation of cardiomyocytes induced by OGD, decreased the release of LDH in cell culture medium, increased miR-21 expression in cells, decreased the expression of miR-21 target proteins PDCD4 and PTEN, decreased the levels of inflammatory factors (interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and interleukin-8 (IL-8)) and oxidative stress factors (ROS and MDA), increased the SOD content, and decreased the cell apoptosis rate. Argon 0-5 interleukin 6 Homo sapiens 302-315 34506261-8 2021 Argon increased the proliferation of cardiomyocytes induced by OGD, decreased the release of LDH in cell culture medium, increased miR-21 expression in cells, decreased the expression of miR-21 target proteins PDCD4 and PTEN, decreased the levels of inflammatory factors (interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and interleukin-8 (IL-8)) and oxidative stress factors (ROS and MDA), increased the SOD content, and decreased the cell apoptosis rate. Argon 0-5 interleukin 6 Homo sapiens 317-321 34879788-4 2021 Generalized estimating equation was used to evaluate the association between exposure to PM2.5 and NO2 and the following serum cytokine levels on the 7 days preceding clinical assessment and serum collection: MCP1, IL-6, IL-8, IL-10, IL-17, IFN-alpha, and TNF-alpha. Nitrogen Dioxide 99-102 interleukin 6 Homo sapiens 215-219 34866927-10 2021 Levels of IL-6 increased significantly with the presence of the mutant 299Gly (G) and 399Ile (T) alleles to reach the highest levels in the Gly299Gly (GG) and the Ile399Ile (TT) genotypes (170 pg/mL (145-208.25) and 112 pg/mL (24-284.75), respectively). gly299gly 140-149 interleukin 6 Homo sapiens 10-14 34858412-0 2021 Matrix Stiffening Enhances DNCB-Induced IL-6 Secretion in Keratinocytes Through Activation of ERK and PI3K/Akt Pathway. Dinitrochlorobenzene 27-31 interleukin 6 Homo sapiens 40-44 34858412-5 2021 Specifically, mechanosensing and signal transduction are coupled with chemical stimuli to regulate cytokine production, and interleukin-6 (IL-6) production is elevated in keratinocytes on stiffer substrates in response to 2,4-dinitrochlorobenzene. Dinitrochlorobenzene 222-246 interleukin 6 Homo sapiens 124-137 34858412-5 2021 Specifically, mechanosensing and signal transduction are coupled with chemical stimuli to regulate cytokine production, and interleukin-6 (IL-6) production is elevated in keratinocytes on stiffer substrates in response to 2,4-dinitrochlorobenzene. Dinitrochlorobenzene 222-246 interleukin 6 Homo sapiens 139-143 34737220-6 2022 Ten proteins were elevated in SA versus MMA in both U-BIOPRED and BIOAIR (alpha-1-antichymotrypsin, apolipoprotein-E, complement component 9, complement factor I, macrophage inflammatory protein-3, interleukin-6, sphingomyelin phosphodiesterase 3, RANK, TGF-beta1, and glutathione S-transferase). mma 40-43 interleukin 6 Homo sapiens 198-211 34127577-8 2021 CLHIV on efavirenz (EFV) had consistently lower TNF-alpha and IL-6 compared with those on ritonavir-boosted lopinavir (LPV/r) at all time points. efavirenz 9-18 interleukin 6 Homo sapiens 62-66 34127577-8 2021 CLHIV on efavirenz (EFV) had consistently lower TNF-alpha and IL-6 compared with those on ritonavir-boosted lopinavir (LPV/r) at all time points. efavirenz 20-23 interleukin 6 Homo sapiens 62-66 34242739-6 2021 RESULTS: Higher IL-6 levels, measured both in plasma and in TLR-2 stimulated blood, was significantly correlated with higher CTQ scores and lower cognitive and social cognitive function. cysteine tryptophylquinone 125-128 interleukin 6 Homo sapiens 16-20 34242739-7 2021 Plasma IL-6 was further observed to partly mediate the association between higher CT scores and lower emotion recognition performance (CTQ total: betaindirect -.0234, 95% CI: -.0573 to -.0074; CTQ physical neglect: betaindirect=-.0316, 95% CI: -.0741 to -.0049). cysteine tryptophylquinone 135-138 interleukin 6 Homo sapiens 7-11 34242739-7 2021 Plasma IL-6 was further observed to partly mediate the association between higher CT scores and lower emotion recognition performance (CTQ total: betaindirect -.0234, 95% CI: -.0573 to -.0074; CTQ physical neglect: betaindirect=-.0316, 95% CI: -.0741 to -.0049). cysteine tryptophylquinone 193-196 interleukin 6 Homo sapiens 7-11 34242739-8 2021 Finally, sequential mediation was observed between plasma IL-6 levels and DMN connectivity in mediating the effects of higher CTQ on lower social cognitive function (betaindirect =-.0618, 95% CI: -.1523 to -0.285). cysteine tryptophylquinone 126-129 interleukin 6 Homo sapiens 58-62 34059950-8 2021 RESULTS: VEGF, MCP-1, IL-8, and IL-6 levels in the aqueous humor of patients with RVO-ME were significantly higher compared with control and were positively correlated with the CRTBT. rvo-me 82-88 interleukin 6 Homo sapiens 32-36 34059950-12 2021 CONCLUSION: VEGF, MCP-1, IL-8, and IL-6 levels were significantly increased in patients with RVO-ME and were positively correlated with ME. rvo-me 93-99 interleukin 6 Homo sapiens 35-39 34476896-4 2021 EVOO decreased TNFalpha and IL6 expression in peripheral blood mononuclear cells, with OO inducing intermediate effects and SO inducing an increase of these proinflammatory markers. evoo 0-4 interleukin 6 Homo sapiens 28-31 34687147-4 2022 In functional assays, pretreatment of EC with simvastatin to inhibit mevalonate metabolism resulted in a dose-dependent reduction in the costimulation of CD45RO+ CD4+ T cell proliferation as well as IL-2, IFNgamma and IL-6 production vs. vehicle-treated EC. Mevalonic Acid 69-79 interleukin 6 Homo sapiens 218-222 34635175-11 2021 The production of inflammatory cytokines (TNF-alpha and IL-6) induced by TNF-alpha and SARS-CoV-2 infection is diminished in the presence of VPA. Valproic Acid 141-144 interleukin 6 Homo sapiens 56-60 34707507-2 2021 We sought to evaluate the role of sIL 6R as a regulator of IL-6-induced vascular remodeling. sil 6r 34-40 interleukin 6 Homo sapiens 59-63 34087397-12 2021 Moreover, as the main bioactive compounds of DSS, paeoniflorin (PF), ferulic acid (FA) and pachymic acid (PA) inhibited IL-6 and TNF-alpha secretion as well as IkappaB-alpha, NF-kappaB (p65), p38 and JNK activation. ferulic acid 69-81 interleukin 6 Homo sapiens 120-124 34639073-1 2021 Our objective is to reveal the molecular mechanism of the anti-inflammatory action of low-molecular-weight heparin (LMWH) based on its influence on the activity of two key cytokines, IFNgamma and IL-6. Heparin, Low-Molecular-Weight 116-120 interleukin 6 Homo sapiens 196-200 34380011-7 2021 Finally, considering the key role played by NF-kappaB in the regulation of inflammation, the effect of STE on the pro-inflammatory cytokines TNF-alpha and IL-6 expression was evaluated. Sterigmatocystin 103-106 interleukin 6 Homo sapiens 155-159 34380011-8 2021 Our results showed the down-regulation of TNF-alpha and IL-6 following STE exposure, suggesting a negative immunomodulatory effect of STE. Sterigmatocystin 71-74 interleukin 6 Homo sapiens 56-60 34380011-8 2021 Our results showed the down-regulation of TNF-alpha and IL-6 following STE exposure, suggesting a negative immunomodulatory effect of STE. Sterigmatocystin 134-137 interleukin 6 Homo sapiens 56-60 34346143-11 2021 Arbutin treatment appreciably reduced the liver marker enzymes, upregulated superoxide dismutase, glutathione peroxidase, total antioxidant capacity, and the hydroxyl scavenging ability, and diminished the tumor necrosis factor-alpha and interleukin-6 levels in the serum of ethanol provoked animals. Arbutin 0-7 interleukin 6 Homo sapiens 238-251 34680642-5 2021 Moreover, the mRNA and protein expression levels of the inflammatory cytokines TNFalpha, IL-6, IL-1beta, and IFNgamma were increased by LPS, but were significantly reduced by AE-GBE treatment. ae-gbe 175-181 interleukin 6 Homo sapiens 89-93 34664888-2 2021 Systemic pro-inflammatory cytokines released from synovial tissues in rheumatoid arthritis, such as interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha, could have direct effects on cardiac electrophysiology, particularly changes in the expression and function of potassium and calcium channels, resulting in QT interval prolongation on surface electrocardiogram (ECG) and an increased predisposition to develop lethal ventricular arrhythmias. Potassium 274-283 interleukin 6 Homo sapiens 124-128 34286801-4 2021 In macrophages, melanoidins significantly suppress the mRNA expression of interleukin (Il)-6, Il-1beta and tumor necrosis factor alpha (Tnf-alpha) with a concomitant inhibitory effect on IL-1beta, IL-6 and TNFalpha secretion, which are increased by ethanol. melanoidin polymers 16-27 interleukin 6 Homo sapiens 197-201 34118221-9 2021 Furthermore, paracrine release of several growth factors like hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), interleukin-6 (IL-6), tumor necrosis factor alpha (TNFalpha), and insulin growth factor (IGF) reinforced the improved response of primary hepatocytes against CCl4 induced hepatotoxicity in the presence of ALA primed ADSCs. Thioctic Acid 342-345 interleukin 6 Homo sapiens 137-150 34118221-9 2021 Furthermore, paracrine release of several growth factors like hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), interleukin-6 (IL-6), tumor necrosis factor alpha (TNFalpha), and insulin growth factor (IGF) reinforced the improved response of primary hepatocytes against CCl4 induced hepatotoxicity in the presence of ALA primed ADSCs. Thioctic Acid 342-345 interleukin 6 Homo sapiens 152-156 34237666-3 2021 Limonoids are a class of triterpenoids known to prevent the release of IL-6, IL-15, IL-1alpha, IL-1beta via TNF and are also known to modulate PI3K/Akt/GSK-3beta, JNK1/2, MAPKp38, ERK1/2, and PI3K/Akt/mTOR signaling pathways and could help to avoid viral infection, persistence, and pathogenesis. Limonins 0-9 interleukin 6 Homo sapiens 71-75 34426617-4 2021 The DMEK group exhibited significantly lower concentrations of several pro-inflammatory cytokines, such as IL-1beta, IL-5, IL-6, IL-10, and IL-8, and granulocyte colony stimulating factor than the BK group. dmek 4-8 interleukin 6 Homo sapiens 123-127 34804428-15 2021 SB203580, PDTC, and alpha-LA reversed the effects of chemerin, reducing IL-6, TNF-alpha, NF-kappaB p-p65, and TGF-beta expression. Thioctic Acid 20-28 interleukin 6 Homo sapiens 72-76 34334139-5 2021 These actions of sodium, potassium and magnesium and other minerals, trace elements and vitamins are likely to be secondary to their action on pro-inflammatory cytokines IL-6, TNF-alpha and IL-17 and metabolism of essential fatty acids that may account for their involvement in the pathobiology of insulin resistance, T2DM, HTN and autoimmune diseases. Potassium 25-34 interleukin 6 Homo sapiens 170-174 34202029-5 2021 We also found that Poly6 inhibits IL-6 production enhanced by SARS-CoV-2 in infected Calu-3 cells at both the transcription and the translation levels, mediated via IL-10 induction in an IFN-I-dependent manner. poly6 19-24 interleukin 6 Homo sapiens 34-38 35274762-7 2022 Additionally, DAPA pretreatment decreased endothelial ROS, IL-6, and TNF-alpha levels in endothelial cells subjected to HG conditions. dapagliflozin 14-18 interleukin 6 Homo sapiens 59-63 35151984-7 2022 The groups treated with GnRHa exhibited a progressive and significant time-dependent decrease in the IL-6 and IL-11 mRNA. gnrha 24-29 interleukin 6 Homo sapiens 101-105 35151984-11 2022 The results showed that ultra-long GnRHa administration can improve outcomes, especially after 3 cycles of GnRHa pretreatment, and endometrial receptivity through IL-6 and IL-11 expression levels of ESC regulated by the miR-124-3p for patients with HRT, who underwent FET cycles. gnrha 35-40 interleukin 6 Homo sapiens 163-167 35503488-11 2022 The IL-6 expression in bulb mucosa was downregulated by the TEA treatment compared to the baseline (P < 0.05). tea 60-63 interleukin 6 Homo sapiens 4-8 35503488-12 2022 CONCLUSIONS: Noninvasive TEA improves gastric accommodation and dyspeptic symptoms, possibly by downregulating the IL-6 expression in duodenal bulb mucosa via the vagal efferent pathway. tea 25-28 interleukin 6 Homo sapiens 115-119 35429917-9 2022 RESULTS: In LMM, a two-fold increase in urinary cesium (Cs) and chromium (Cr) was statistically associated with -35.22% (95% confidence interval (CI): -53.17, -10.40) changes in interleukin 6 (IL-6) and -11.13% (95 %CI: -20.67, -0.44) in IL-8. Chromium 64-72 interleukin 6 Homo sapiens 178-191 35429917-9 2022 RESULTS: In LMM, a two-fold increase in urinary cesium (Cs) and chromium (Cr) was statistically associated with -35.22% (95% confidence interval (CI): -53.17, -10.40) changes in interleukin 6 (IL-6) and -11.13% (95 %CI: -20.67, -0.44) in IL-8. Chromium 64-72 interleukin 6 Homo sapiens 193-197 35429917-9 2022 RESULTS: In LMM, a two-fold increase in urinary cesium (Cs) and chromium (Cr) was statistically associated with -35.22% (95% confidence interval (CI): -53.17, -10.40) changes in interleukin 6 (IL-6) and -11.13% (95 %CI: -20.67, -0.44) in IL-8. Chromium 74-76 interleukin 6 Homo sapiens 178-191 35429917-9 2022 RESULTS: In LMM, a two-fold increase in urinary cesium (Cs) and chromium (Cr) was statistically associated with -35.22% (95% confidence interval (CI): -53.17, -10.40) changes in interleukin 6 (IL-6) and -11.13% (95 %CI: -20.67, -0.44) in IL-8. Chromium 74-76 interleukin 6 Homo sapiens 193-197 35429917-10 2022 Urinary copper (Cu) and selenium (Se) was statistically associated with IL-6 (88.10%, 95%CI: 34.92, 162.24) and tumor necrosis factor-alpha (TNF-alpha) (22.32%, 95%CI: 3.28, 44.12), respectively. Selenium 24-32 interleukin 6 Homo sapiens 72-76 35315502-4 2022 In the present study, the efficacy of co-targeting IL-6 and IL-8 in human ovarian cancer cells by bazedoxifene (Baze) + SCH527123 (SCH) treatment was examined. bazedoxifene 98-110 interleukin 6 Homo sapiens 51-55 35315502-4 2022 In the present study, the efficacy of co-targeting IL-6 and IL-8 in human ovarian cancer cells by bazedoxifene (Baze) + SCH527123 (SCH) treatment was examined. bazedoxifene 112-116 interleukin 6 Homo sapiens 51-55 35315502-8 2022 Compared with the DMSO control, the combination of IL-6/glycoprotein 130 inhibitor Baze and IL-8 inhibitor SCH synergistically inhibited cell viability in ovarian cancer cells. bazedoxifene 83-87 interleukin 6 Homo sapiens 51-55 35625225-6 2022 Furthermore, cefiderocol reduces interleukin-6 (IL-6), interleukin-1beta (IL-1beta) and TNF-alpha release in peripheral blood mononuclear cells (PBMCs) following LPS stimulation in a dose-dependent manner. cefiderocol 13-24 interleukin 6 Homo sapiens 33-46 35625225-6 2022 Furthermore, cefiderocol reduces interleukin-6 (IL-6), interleukin-1beta (IL-1beta) and TNF-alpha release in peripheral blood mononuclear cells (PBMCs) following LPS stimulation in a dose-dependent manner. cefiderocol 13-24 interleukin 6 Homo sapiens 48-52 35101812-4 2022 The balance between omega-3 and omega-6 levels in the cell membrane has a critical role in regulating the equilibrium between proinflammatory and antiinflammatory processes and inducing IL-6 production. omega-3 20-27 interleukin 6 Homo sapiens 186-190 35431807-5 2022 In human whole blood cultures pCF3-diEPP inhibited the LPS-induced secretion of IL-6, TNF-alpha and IL-1beta. pcf3-diepp 30-40 interleukin 6 Homo sapiens 80-84 35456796-8 2022 The anti-inflammatory properties of stevioside were confirmed in vitro by decreasing TNF-alpha, IL-1beta, IL-6 synthesis and inhibiting of NF-kappaB transcription factor, and in vivo by inhibiting NF-kappaB and MAPK in laboratory animals. stevioside 36-46 interleukin 6 Homo sapiens 106-110 35164664-6 2022 Nintedanib reduced the production of pro-inflammatory cytokines interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) in TNF-alpha-induced CHON-001 chondrocytes. nintedanib 0-10 interleukin 6 Homo sapiens 64-77 35164664-6 2022 Nintedanib reduced the production of pro-inflammatory cytokines interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) in TNF-alpha-induced CHON-001 chondrocytes. nintedanib 0-10 interleukin 6 Homo sapiens 79-83 35092909-9 2022 RESULTS: FLA had a significant inhibitory effect on the proliferation of HFLS-RA induced by IL-1beta, which was accompanied by decreased expression levels of TNF-alpha, IL-6, MMP-1, MMP-3, COX-2 and PGE2. fla 9-12 interleukin 6 Homo sapiens 169-173 35231918-14 2022 The target relationship between miR-338-5p and IL-6 was proved. mir-338-5p 32-42 interleukin 6 Homo sapiens 47-51 35168647-4 2022 One, 10 and 100 muM triamcinolone induced significant decrease in the production of IL-6 and IL-8 at 48, 72 and 96 h, adding the time point 12 h for IL-8. Triamcinolone 20-33 interleukin 6 Homo sapiens 84-88 35168647-7 2022 While triamcinolone inhibited the production of IL-6 and IL-8 by LEE cells, PRP induced an increase in these cytokines compared with controls. Triamcinolone 6-19 interleukin 6 Homo sapiens 48-52 35216089-7 2022 In CD biopsies inflammation markers IL-1beta and IL-6 were increased in the enterocytes, and also in Pot-CD before the onset of the intestinal lesion and in GFD-CD. pot-cd 101-107 interleukin 6 Homo sapiens 49-53 35123452-11 2022 A core network containing the pro-inflammatory TNFalpha, IL-6, IL-1beta, MAPKs, and RIG-I receptor signaling pathway was further confirmed as the crucial targets for anti-influenza efficacy of TFA. Trifluoroacetic Acid 193-196 interleukin 6 Homo sapiens 57-61 35127774-7 2021 Levels of acute phase reactant SAA and IL-6 decreased significantly after treatment with GC and leflunomide, while levels of IL-8, IL-18, and CHI3L1 did not change significantly during the follow-up period. Leflunomide 96-107 interleukin 6 Homo sapiens 39-43 35087566-9 2021 Based on the CTD database, PPARG, ADAM12, IL6, SMAD3, and TIMP2 were identified to interact with selenium, sodium selenite, and T-2 toxin. Selenium 97-105 interleukin 6 Homo sapiens 42-45 35181630-0 2022 Technical Note: Bimodal Negative Interference of Biotin in Roche IL-6 Immunoassay. Biotin 49-55 interleukin 6 Homo sapiens 65-69 35181630-5 2022 RESULTS: We observed negative interference of biotin in IL-6 assay but interference was bimodal as maximum negative interference was observed with 100 ng/mL biotin but not with 1000 ng/mL. Biotin 46-52 interleukin 6 Homo sapiens 56-60 35181630-5 2022 RESULTS: We observed negative interference of biotin in IL-6 assay but interference was bimodal as maximum negative interference was observed with 100 ng/mL biotin but not with 1000 ng/mL. Biotin 157-163 interleukin 6 Homo sapiens 56-60 35181630-7 2022 CONCLUSIONS: Biotin showed negative interference with IL-6 assay. Biotin 13-19 interleukin 6 Homo sapiens 54-58 3265388-9 1988 Moreover, glucocorticosteroids potentiate the synergistic effect of IL1 and IL6 on their B lymphocyte target, an effect comparable to that exerted on hepatocytes. glucocorticosteroids 10-30 interleukin 6 Homo sapiens 76-79 2854727-2 1988 AR 12456 enhanced the uptake and degradation of 125 I-LDL in HEP G2, but inhibited this pathway in HSF. Argon 0-2 interleukin 6 Homo sapiens 99-102 3834057-1 1985 The effect of 4-(4"-chlorobenzyloxy)benzoic acid (MII), a metabolite of a new hypolipidemic agent 4-(4"-chlorobenzyloxy)benzyl nicotinate (KCD-232), on lipid synthesis and cell growth was studied in human skin fibroblasts (HSF), mouse skin fibroblasts (MSF) and other rodent-derived cell. Methicillin 50-53 interleukin 6 Homo sapiens 223-226 3834057-7 1985 These results suggested a possibility that the different effects of MII on the growth of HSF and MSF might be due partly to differences in the effect of MII on fatty acid synthesis between human and rodent cells. Methicillin 68-71 interleukin 6 Homo sapiens 89-92 3834057-7 1985 These results suggested a possibility that the different effects of MII on the growth of HSF and MSF might be due partly to differences in the effect of MII on fatty acid synthesis between human and rodent cells. Methicillin 153-156 interleukin 6 Homo sapiens 89-92 6693432-5 1984 These effectors also increased the reactivity of glucocerebrosidase to the inhibitor conduritol B epoxide; HSF alone had no effect (t1/2 = 19 +/- 0.5 min) whereas the maximum rate of inactivation (t1/2 = 4.0 min) by conduritol B epoxide was achieved in the presence of a mixture of PS (1 microgram) and HSF (3 micrograms). conduritol epoxide 85-105 interleukin 6 Homo sapiens 107-110 6601516-3 1983 HSF did not appear to have a serine group(s) in its "active" site since its biologic activity remained intact following treatment with an irreversible serine esterase inhibitor (phenylmethylsulfonyl fluoride). Phenylmethylsulfonyl Fluoride 178-207 interleukin 6 Homo sapiens 0-3 34007158-9 2021 FTY720 reduced the secretion of IL-1beta, IL-6, and IL-8 from TNF-alpha-stimulated MH7A cells in a dose-dependent manner. Fingolimod Hydrochloride 0-6 interleukin 6 Homo sapiens 42-46 33949772-7 2021 Moreover, nintedanib treatment inhibited expression of several cytokines/chemokines, including tumour necrosis factor-alpha, interleukin-1beta and interleukin-6, monocyte chemoattractant protein-1 and prevented infiltration of macrophages to the injured peritoneum. nintedanib 10-20 interleukin 6 Homo sapiens 147-160 33952453-3 2021 In the present study, we combined the PARPi, talazoparib, and the IL-6 inhibitor, bazedoxifene, for the treatment of human ovarian cancer cells. bazedoxifene 82-94 interleukin 6 Homo sapiens 66-70 33847390-13 2021 Moreover, histological and ultrastructural improvements were seen in the rat population treated with BPA and Se, whereas ALT and AST levels were lowered and malondialdehyde (MDA), glutathione peroxidase (GPx), human C reactive protein (hCRP), and the serum levels of interleukin-6 (IL-6) were significantly modulated. Selenium 109-111 interleukin 6 Homo sapiens 267-280 33847390-13 2021 Moreover, histological and ultrastructural improvements were seen in the rat population treated with BPA and Se, whereas ALT and AST levels were lowered and malondialdehyde (MDA), glutathione peroxidase (GPx), human C reactive protein (hCRP), and the serum levels of interleukin-6 (IL-6) were significantly modulated. Selenium 109-111 interleukin 6 Homo sapiens 282-286 33592131-8 2021 The reduction in IL-6 level following treatment with lipo-PGE1 may alleviate inflammation. lipo-pge1 53-62 interleukin 6 Homo sapiens 17-21 33876818-11 2021 Moreover, butyric acid alleviated CIH-induced cell proliferation, lipid formation and inflammatory status and promoted cell apoptosis through regulating related genes including p21, PPARgamma, C/EBPa, IL-1beta, IL-6, TLR4, caspase-8 and caspase-3. Butyric Acid 10-22 interleukin 6 Homo sapiens 211-215 33827267-2 2021 This systematic review and dose-response meta-analysis of randomized controlled trials was performed to summarize the effects of ALA supplementation on inflammatory markers such as C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in adults. Thioctic Acid 129-132 interleukin 6 Homo sapiens 207-220 33827267-10 2021 The findings of the meta-analysis showed that ALA supplementation significantly reduced CRP (WMD: -0.69 mg/L, 95% CI: -1.13, -0.26, P=0.002), IL-6 (WMD: -1.83 pg/ml, 95% CI: -2.90, -0.76, P=0.001), and TNF-alpha concentrations (WMD: -0.45 pg/ml, 95% CI: -0.85, -0.04, P=0.032). Thioctic Acid 46-49 interleukin 6 Homo sapiens 142-146 33556841-9 2021 Melokhanine K and meloyine II showed potent inhibitory activity on the production of nitric oxide, interleukin-6, and tumor necrosis factor-alpha in LPS-induced RAW 264.7 macrophages, whereas epi-scandomelonine and epi-scandomeline exhibited certain cytotoxic activity against MOLT-4 cells with IC50 values 5.2 and 1.5 muM, respectively. melokhanine k 0-13 interleukin 6 Homo sapiens 99-112 33524139-7 2021 Following DAAs therapy, the levels of ROS, IL-1beta, IL-6, IL-8 and TNF-alpha were significantly decreased in the three HCV groups. daas 10-14 interleukin 6 Homo sapiens 53-57 33849098-7 2021 LMWH significantly reduced levels of tumor necrosis factor-alpha, interleukin-6, and D-dimer, and the incidence of multiple organ dysfunction syndrome (MODS), with statistically significant differences. Heparin, Low-Molecular-Weight 0-4 interleukin 6 Homo sapiens 66-79 33545432-9 2021 These results suggest that plasma IL-6 level may be a promising biological marker for predicting the likely treatment response to paroxetine in individual patients with MDD. Paroxetine 130-140 interleukin 6 Homo sapiens 34-38 33602262-7 2021 RESULTS: All the SSRIs, including paroxetine, fluoxetine, sertraline, citalopram, and fluvoxamine, show a visible cytotoxicity within the range of applied doses, and a paradoxical effect on astrocytic inflammatory responses as manifested by the promotion of inducible nitric oxide synthase (iNOS) and/or nitric oxide (NO) and the inhibition of interleukin 6 (IL-6) and/or interleukin 1beta (IL-1beta). Paroxetine 34-44 interleukin 6 Homo sapiens 344-357 33602262-7 2021 RESULTS: All the SSRIs, including paroxetine, fluoxetine, sertraline, citalopram, and fluvoxamine, show a visible cytotoxicity within the range of applied doses, and a paradoxical effect on astrocytic inflammatory responses as manifested by the promotion of inducible nitric oxide synthase (iNOS) and/or nitric oxide (NO) and the inhibition of interleukin 6 (IL-6) and/or interleukin 1beta (IL-1beta). Paroxetine 34-44 interleukin 6 Homo sapiens 359-363 33602262-7 2021 RESULTS: All the SSRIs, including paroxetine, fluoxetine, sertraline, citalopram, and fluvoxamine, show a visible cytotoxicity within the range of applied doses, and a paradoxical effect on astrocytic inflammatory responses as manifested by the promotion of inducible nitric oxide synthase (iNOS) and/or nitric oxide (NO) and the inhibition of interleukin 6 (IL-6) and/or interleukin 1beta (IL-1beta). Fluoxetine 46-56 interleukin 6 Homo sapiens 344-357 33602262-7 2021 RESULTS: All the SSRIs, including paroxetine, fluoxetine, sertraline, citalopram, and fluvoxamine, show a visible cytotoxicity within the range of applied doses, and a paradoxical effect on astrocytic inflammatory responses as manifested by the promotion of inducible nitric oxide synthase (iNOS) and/or nitric oxide (NO) and the inhibition of interleukin 6 (IL-6) and/or interleukin 1beta (IL-1beta). Fluoxetine 46-56 interleukin 6 Homo sapiens 359-363 33359650-5 2021 We demonstrate the ICS fluticasone propionate (FP) and two selective non-steroidal (GRT7) and steroidal (GRT10) glucocorticoid receptor (GR) agonists significantly suppress pro-inflammatory (IL-6 and IL-8) and antiviral (IFN-lambda1) cytokine production and the expression of the interferon-stimulated genes (ISGs) OAS and viperin in RV-infected bronchial epithelial cells, with a consequent increase of viral replication. Fluticasone 23-45 interleukin 6 Homo sapiens 191-195 33427831-5 2021 The Bax/Bcl2 expression ratio was increased up to 11-fold in cells pre-treated with 60 muM limonoids for 48 h. Apart from this, the limonoids also induced the expression of p21, and exhibited anti-inflammatory activity through decreasing the expression of cox-2, NF-kappaB and IL-6. Limonins 91-100 interleukin 6 Homo sapiens 277-281 33044583-11 2021 However, both the 1.8 cineole treatment and alpha-pinene treatments significantly decreased TNF-alpha, IL-1beta, IL-6, and eNOS mRNA expression induced by LPS. alpha-pinene 44-56 interleukin 6 Homo sapiens 113-117 33044583-13 2021 However, 1.8 cineole and alpha-pinene, other major components of MC fruit, ameliorated LPS-induced damage in HUVECs at cellular and biomolecular levels (TNF-alpha, IL-1beta, IL-6, and eNOS). alpha-pinene 25-37 interleukin 6 Homo sapiens 174-178 33321447-0 2021 Effect of chromium supplementation on hs-CRP, TNF-alpha and IL-6 as risk factor for cardiovascular diseases: A meta-analysis of randomized-controlled trials. Chromium 10-18 interleukin 6 Homo sapiens 60-64 33321447-1 2021 BACKGROUND: The objective of this systematic review is to assess the relationship between chromium supplementation and inflammatory biomarkers levels (hs-CRP, TNF-alpha, IL-6) as risk factor for cardiovascular diseases. Chromium 90-98 interleukin 6 Homo sapiens 170-174 33141310-6 2021 In addition, ADU-S100 promoted the secretion of IFNbeta and IL-6, and the activation of TBK1 (TANK-binding kinase 1)/NF-kappaB (nuclear factor kappa-B) pathway. UNII-FMW9ZVF53N 13-21 interleukin 6 Homo sapiens 60-64 33416163-7 2021 Furthermore, addition of IL-6 to ZA-pretreated gefitinib-resistant cell lines abrogated the effect of ZA and restored the cellular resistance to tyrosine kinase inhibitors. Zoledronic Acid 33-35 interleukin 6 Homo sapiens 25-29 33532036-0 2021 Retracted: Hydrostatin-SN10 Ameliorates Pancreatitis-Induced Lung Injury by Affecting IL-6-Induced JAK2/STAT3-Associated Inflammation and Oxidative Stress. hydrostatin-sn10 11-27 interleukin 6 Homo sapiens 86-90 32971524-5 2021 The efficacy of silymarin was assessed by measuring serum C-reactive protein (CRP) (mg/dL), interleukin (IL)-6 (pg/mL), and IL-10 (pg/mL). Silymarin 16-25 interleukin 6 Homo sapiens 92-110 32971524-7 2021 Data analysis showed that compared to the placebo, silymarin could decrease CRP, IL-6, and raise IL-10 significantly (the p values for all variables were <0.001). Silymarin 51-60 interleukin 6 Homo sapiens 81-85 33231425-0 2020 NiCoO2@CeO2 Nanoboxes for Ultrasensitive Electrochemical Immunosensing Based on the Oxygen Evolution Reaction in a Neutral Medium: Application for Interleukin-6 Detection. nicoo2 0-6 interleukin 6 Homo sapiens 147-160 33231425-7 2020 A sandwich-type electrochemical immunosensor using NiCoO2@CeO2 NBs as electrocatalytic labels features a broad linear range for interleukin-6 detection from 2.5 x 10-5 to 10 ng mL-1, with a low detection limit of 7 fg mL-1. nicoo2 51-57 interleukin 6 Homo sapiens 128-141 33231425-7 2020 A sandwich-type electrochemical immunosensor using NiCoO2@CeO2 NBs as electrocatalytic labels features a broad linear range for interleukin-6 detection from 2.5 x 10-5 to 10 ng mL-1, with a low detection limit of 7 fg mL-1. ceric oxide 58-62 interleukin 6 Homo sapiens 128-141 33231425-7 2020 A sandwich-type electrochemical immunosensor using NiCoO2@CeO2 NBs as electrocatalytic labels features a broad linear range for interleukin-6 detection from 2.5 x 10-5 to 10 ng mL-1, with a low detection limit of 7 fg mL-1. Bromosuccinimide 63-66 interleukin 6 Homo sapiens 128-141 33381228-2 2020 Bazedoxifene is a new IL6/GP130 inhibitor recommended by the FDA for clinical use as a selective estrogen receptor modulator. bazedoxifene 0-12 interleukin 6 Homo sapiens 22-25 33193842-4 2020 The low-molecular-weight heparins (LMWH) show anti-coagulant capability as well as reducing levels of inflammatory factors, including interleukin (IL)-6. Heparin, Low-Molecular-Weight 4-33 interleukin 6 Homo sapiens 134-152 32998017-8 2020 Knockdown of miR-370-3p inhibited the expression of HMGB1 and suppressed the proliferation but promoted the apoptosis of HK-2 cells injured by LPS as well as the expression of TNF-alpha, IL-6 and IL-1beta. mir-370-3p 13-23 interleukin 6 Homo sapiens 187-191 33496116-9 2020 The results of molecular docking showed that baicalein,berberine,licochalcone A and 6-gingerol had a high affinity with SRC,STAT3,TNF and IL6. baicalein 45-54 interleukin 6 Homo sapiens 138-141 33244818-5 2021 In RA patients, the levels of IL-6 have been found to be correlated with the disease, and this work focused on detecting IL-6 by its aptamer with the help of a biotin-streptavidin strategy on an interdigitated electrode. Biotin 160-166 interleukin 6 Homo sapiens 121-125 32382733-1 2020 On human lung parenchymal explants, chloroquine concentration clinically achievable in the lung (100 muM) inhibited the lipopolysaccharide-induced release of TNF-alpha (by 76%), IL-6 (by 68%), CCL2 (by 72%) and CCL3 (by 67%). Chloroquine 36-47 interleukin 6 Homo sapiens 178-182 33298879-10 2020 Finally, knockdown of IL-34 in TICs with specific antisense oligonucleotides with: a specific antisesne oligonucleotide decreased IL-6 production and the number of TAMs producing this cytokine. antisesne oligonucleotide 94-119 interleukin 6 Homo sapiens 130-134 32918926-5 2020 Interestingly, we found that lebecetin reduced the levels of the pro-inflammatory cytokines TNF-alpha, IL-6, and IL-8 while it partially increased LPS-induced secretion of the immunomodulatory cytokine IL-10. lebecetin 29-38 interleukin 6 Homo sapiens 103-107 33012543-3 2020 Among those with mortality, an increased concentration of inflammatory biomarkers (interleukin-6 and C-reactive protein) was noted with a lack of response to interleukin-6 blockade, remdesivir, and/or convalescent plasma. remdesivir 182-192 interleukin 6 Homo sapiens 83-96 33048256-14 2021 AMPK activator A769662 reduced IL-6 release. 4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile 15-22 interleukin 6 Homo sapiens 31-35 33023123-5 2020 EVOO supplementation was associated with a reduction in body weight, waist circumference, body mass index (BMI), alanine transaminase and FLI, as well as interleukin (IL)-6, IL-17A, tumor necrosis factor-alpha and IL-1B, while IL-10 increased. evoo 0-4 interleukin 6 Homo sapiens 154-172 32735798-13 2020 All agonists induced the secretion of IL-1ss, IL-8, and TNFalpha in microglia cells while in real-time PCR, LPS and Pam induced the expression of IL-6, IL-1ss and iNOS. pam 116-119 interleukin 6 Homo sapiens 146-150 32794617-4 2020 Uric acid sodium salt induces caspase-1 activation, cell death, and the expression of proinflammatory cytokines, including IL-1alpha, IL-6, and IL-8, in the human keratinocyte HOK-16B cell line. Uric acid sodium salt 0-21 interleukin 6 Homo sapiens 134-138 32863319-11 2020 Furthermore, GLUT4 inhibitor, WZB117, blocked the stimulatory effect of glucose on LPS-induced IL-6 mRNA expression. WZB117 30-36 interleukin 6 Homo sapiens 95-99 32782515-0 2020 Sodium valproate combined with levetiracetam in pediatric epilepsy and its influence on NSE, IL-6, hs-CRP and electroencephalogram improvement. Valproic Acid 0-16 interleukin 6 Homo sapiens 93-97 32782515-1 2020 Efficacy of sodium valproate combined with levetiracetam (LEV) in pediatric epilepsy and its influence on neuron-specific enolase (NSE), interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) as well as electroencephalogram (EEG) improvement were studied. Valproic Acid 12-28 interleukin 6 Homo sapiens 137-150 32782515-8 2020 In the treatment of pediatric epilepsy, sodium valproate combined with LEV produces better efficacy, fewer adverse reactions, significantly improves patients" QOL and notably lowers the content of NSE, IL-6 and hs-CRP with notable EEG improvement, so it is a safe and reliable treatment that is worth popularization. Valproic Acid 40-56 interleukin 6 Homo sapiens 202-206 32797769-3 2020 Moreover, ELISA assay showed that acacetin dose-dependently attenuated LPS-induced increases of TNF-alpha, IL-6 and IL-1beta in PDL cells. acacetin 34-42 interleukin 6 Homo sapiens 107-111 32634445-3 2020 We discovered that inclusion of sodium pyruvate in culture media during infection of mouse bone marrow derived macrophages with influenza A virus impaired cytokine production (IL-6, IL-1beta, and TNF-alpha). SODIUM PYRUVATE 32-47 interleukin 6 Homo sapiens 176-180 33164356-4 2020 The results showed that adenosine, epigoitrin, chlorogenic acid, caffeic acid, cichoric acid, corynoline, baicalin, wogonoside, wogonin and oroxylin A had a certain regulatory effect on inflammatory factor tumor necrosis factor(TNF-alpha), interleukin(IL-1beta) and IL-6 at specific concentrations in a dose-dependent manner. caffeic acid 65-77 interleukin 6 Homo sapiens 266-270 33164356-4 2020 The results showed that adenosine, epigoitrin, chlorogenic acid, caffeic acid, cichoric acid, corynoline, baicalin, wogonoside, wogonin and oroxylin A had a certain regulatory effect on inflammatory factor tumor necrosis factor(TNF-alpha), interleukin(IL-1beta) and IL-6 at specific concentrations in a dose-dependent manner. corynoline 94-104 interleukin 6 Homo sapiens 266-270 33164356-4 2020 The results showed that adenosine, epigoitrin, chlorogenic acid, caffeic acid, cichoric acid, corynoline, baicalin, wogonoside, wogonin and oroxylin A had a certain regulatory effect on inflammatory factor tumor necrosis factor(TNF-alpha), interleukin(IL-1beta) and IL-6 at specific concentrations in a dose-dependent manner. wogonoside 116-126 interleukin 6 Homo sapiens 266-270 32973791-9 2020 These data are the first to show heme-induced IL-6 expression in vivo, suggesting that hemolysis may play a role in the elevated IL-6 and cardiac hypertrophy seen in patients and mice with SCD. Heme 33-37 interleukin 6 Homo sapiens 46-50 32973791-9 2020 These data are the first to show heme-induced IL-6 expression in vivo, suggesting that hemolysis may play a role in the elevated IL-6 and cardiac hypertrophy seen in patients and mice with SCD. Heme 33-37 interleukin 6 Homo sapiens 129-133 32631821-7 2020 In women <=45 years, TFVdp was negatively associated with IL-6 and sCD163, while FTCtp was positively associated with sCD163 and IL-6 in women >=60 years. 5-fluoro-1-(2-hydroxymethyl)-1,3-oxathiolane-5-yl-cytidine-5'-triphosphate 81-86 interleukin 6 Homo sapiens 129-133 32824020-8 2020 The post-intervention TNF-alpha, IL-6, and SAA concentrations were more significantly lower in the HNBP than in the NBP group (p < 0.05). 2,2',4,4',6,6'-Hexanitrobiphenyl 99-103 interleukin 6 Homo sapiens 33-37 32793908-8 2020 TMPRSS2, inflammatory cytokines G-CSF, M- CSF, IL-1a, IL-6 and MCP-1 are suppressed by MEKi alone or in combination with remdesivir. remdesivir 121-131 interleukin 6 Homo sapiens 54-58 32388278-3 2020 By the aid of structure-based drug design, in this study, two series of bazedoxifene based analogues were designed to target GP130 D1 domain and block the IL-6/GP130/STAT3 signaling pathway for antitumor treatment. bazedoxifene 72-84 interleukin 6 Homo sapiens 155-159 32533463-8 2020 In addition, miR-194-5p inhibited the release of COX2 and pro-inflammatory cytokines (TNF-alpha, TGF-beta, IL-1beta and IL-6). mir-194-5p 13-23 interleukin 6 Homo sapiens 120-124 32722537-6 2020 These mapped to ~8700 gene bodies, whose genes functionally controlled organelle synthesis and Th2 pathways (IL6, TSLP). th2 95-98 interleukin 6 Homo sapiens 109-112 32648126-0 2022 Kang-ai Injection () Inhibits Gastric Cancer Cells Proliferation through IL-6/STAT3 Pathway. kang-ai 0-7 interleukin 6 Homo sapiens 73-77 32179099-6 2020 LPA was found to prevent survival of Sa3, a human gingival epithelium-derived tumor cell line, activate Sa3 through Ca2+ mobilization, and release interleukin 6 from Sa3 in vitro. lysophosphatidic acid 0-3 interleukin 6 Homo sapiens 147-160 31887416-0 2020 Increased circulatory IL-6 during 8-week fluoxetine treatment is a risk factor for suicidal behaviors in youth. Fluoxetine 41-51 interleukin 6 Homo sapiens 22-26 32273089-7 2020 Moreover, LIUS ameliorated IL-6/STAT3 inflammatory pathway via inhibiting IL-6-induced STAT3 phosphorylation, DNA binding activity and, the expressions of its downstream effectors in ovarian CSCs while no explicit effect was found in the corresponding bulk cancer cells. lius 10-14 interleukin 6 Homo sapiens 27-31 32273089-7 2020 Moreover, LIUS ameliorated IL-6/STAT3 inflammatory pathway via inhibiting IL-6-induced STAT3 phosphorylation, DNA binding activity and, the expressions of its downstream effectors in ovarian CSCs while no explicit effect was found in the corresponding bulk cancer cells. lius 10-14 interleukin 6 Homo sapiens 74-78 32273089-8 2020 Additional approaches in molecular studies showed that LIUS disrupts CSC features via inhibiting IL-6/STAT3 inflammatory pathway. lius 55-59 interleukin 6 Homo sapiens 97-101 32273089-9 2020 Collectively, our data for the first time elucidate IL-6/STAT3 inflammatory loop as the key CSC or cancer stemness pathway in ovarian cancer by LIUS treatment, providing a novel and potential therapy and a promising target in ovarian cancer. lius 144-148 interleukin 6 Homo sapiens 52-56 32419390-7 2020 In vitro cultures revealed that alginate can dose dependently induce macrophages to secrete TNFalpha, IL-6, IL-1beta, and GM-CSF. Alginates 32-40 interleukin 6 Homo sapiens 102-106 32419390-8 2020 Addition of pCM to the cultures attenuates the secretion of TNFalpha (p = 0.023) and IL-6 (p < 0.0001) by alginate or lipopolysaccharide (LPS) stimulations. Alginates 106-114 interleukin 6 Homo sapiens 85-89 31129702-10 2020 HCY and vitamin B6 correlated with age-corrected RTL (r = - 0.086, p < 0.001; r = 0.04, p = 0.031, respectively), IL-6 (r = 0.148, p < 0.001; r = - 0.249, p < 0.001, respectively), and hs-CRP (r = 0.101, p < 0.001; r = - 0.320, p < 0.001, respectively). Vitamin B 6 8-18 interleukin 6 Homo sapiens 117-121 32343308-6 2020 The simultaneous administration of DEX and sufentanil significantly reduced plasma IL-6 and TNF-alpha concentrations and increased IL-10 level (P < 0.0001, P = 0.0003, and P = 0.0345, respectively), accompanied by better postoperative delirium categories and health statuses of patients (P = 0.024 and P < 0.05, respectively). Sufentanil 43-53 interleukin 6 Homo sapiens 83-87 32477139-10 2020 IL-6 (P < 0.001) levels were lower in the DEX group at T1, and TNF-alpha (P = 0.003) levels were lower in the DEX group at T1 and T3, but IL-1beta levels were similar between the two groups. Dextromethorphan 42-45 interleukin 6 Homo sapiens 0-4 32523885-3 2020 The aim of the present study was to evaluate the effect of CLA supplementation on serum levels of interleukin (IL)-6 and sirtuin1 (SIRT1) in patients with COPD. Linoleic Acids, Conjugated 59-62 interleukin 6 Homo sapiens 98-116 32176561-0 2020 Interleukin-6 Response of C2C12 Myotubes Stimulated with Lipopolysaccharide and Lipoic Acid. Thioctic Acid 80-91 interleukin 6 Homo sapiens 0-13 32176561-1 2020 Our previous study explored the dual effect of lipoic acid on the regulation of IL-6 expression in C2C12 myotubes. Thioctic Acid 47-58 interleukin 6 Homo sapiens 80-84 32176561-12 2020 Moreover, lipoic acid significantly upregulated IL-6, IL-6Ra, and gp130 mRNA expression and significantly increased caspase-3 activity but did not induce apoptotic cell formation. Thioctic Acid 10-21 interleukin 6 Homo sapiens 48-52 32176561-16 2020 Lipoic acid-induced IL-6 mRNA expression may be mediated by IL-6 classical signaling in C2C12 myotubes. Thioctic Acid 0-11 interleukin 6 Homo sapiens 20-24 32176561-16 2020 Lipoic acid-induced IL-6 mRNA expression may be mediated by IL-6 classical signaling in C2C12 myotubes. Thioctic Acid 0-11 interleukin 6 Homo sapiens 60-64 32122212-8 2020 In THP-1 cells, a human monocyte model, FA dose-dependently suppressed DNCB-elicited up-regulation of CD54 and CD86 at cell surface, secretion of pro-inflammatory cytokines IL-6 and TNF-alpha, and NFkappaB signaling activation.Conclusion: Our findings demonstrated that FA could serve as a promising therapeutic agent in AD treatment. Dinitrochlorobenzene 71-75 interleukin 6 Homo sapiens 173-177 2523818-5 1989 The results suggest that human monocyte IL-6 carries O-glycosidically bound carbohydrates with a Gal(beta 1-3)Gal-NAc core to which only sialic acid is bound. N-Acetylneuraminic Acid 137-148 interleukin 6 Homo sapiens 40-44 31974519-4 2020 The production of interleukin (IL)-6 and IL-8 by human epidermal keratinocytes stimulated by heat-killed Cutibacterium acnes was significantly inhibited by ozenoxacin at concentrations from 1 to 30 mug ml-1. ozenoxacin 156-166 interleukin 6 Homo sapiens 18-36 2523818-8 1989 Incubation of monocytes with tunicamycin and 1-deoxymynnojirimycin and treatment of IL-6 with endoglucosaminidase H suggested that the 27.5 kDa form of IL-6 carries at least one N-linked complex-type oligosaccharide chain. type 195-199 interleukin 6 Homo sapiens 152-156 31974519-5 2020 Likewise, the production of IL-6, IL-8, and tumor necrosis factor alpha by stimulated THP-1 cells, a human monocyte cell line, was inhibited by ozenoxacin at concentrations from 1 to 30 mug ml-1. ozenoxacin 144-154 interleukin 6 Homo sapiens 28-32 2572101-1 1989 Skin biopsies from 5 patients with chronic plaque psoriasis were examined to test the effect of topical treatment with a new synthetic vitamin D3 analogue, MC 903, on epidermal interleukin 6 (IL-6) and tumour necrosis factor alpha (TNF alpha). calcipotriene 156-162 interleukin 6 Homo sapiens 177-190 3006091-2 1986 The specific binding and internalization of human 125I-labeled LDL are dose-dependently increased in HSF by CA of the verapamil series (verapamil, anipamil, gallopamil, ronipamil, and diltiazem), but neither by CA of the dihydropyridine series (nifedipine, nitrendipine) nor by flunarizine. anipamil 147-155 interleukin 6 Homo sapiens 101-104 3006091-2 1986 The specific binding and internalization of human 125I-labeled LDL are dose-dependently increased in HSF by CA of the verapamil series (verapamil, anipamil, gallopamil, ronipamil, and diltiazem), but neither by CA of the dihydropyridine series (nifedipine, nitrendipine) nor by flunarizine. Nifedipine 245-255 interleukin 6 Homo sapiens 101-104 32317293-10 2020 ALKS 4230 treatment induced significantly lower levels of proinflammatory cytokines, including tumor necrosis factor alpha, interleukin-6, and interferon gamma relative to rhIL-2. alks 4230 0-9 interleukin 6 Homo sapiens 124-137 3006091-2 1986 The specific binding and internalization of human 125I-labeled LDL are dose-dependently increased in HSF by CA of the verapamil series (verapamil, anipamil, gallopamil, ronipamil, and diltiazem), but neither by CA of the dihydropyridine series (nifedipine, nitrendipine) nor by flunarizine. Flunarizine 278-289 interleukin 6 Homo sapiens 101-104 32214022-1 2020 The aim of this study was to assess the influence of lead (Pb) at low concentrations (imitating Pb levels in human blood in chronic environmental exposure to this metal) on interleukin 1beta (IL-1beta) and interleukin 6 (IL-6) concentrations and the activity and expression of COX-1 and COX-2 in THP-1 macrophages. Lead 59-61 interleukin 6 Homo sapiens 206-219 3966907-4 1985 In HSF and SMC, a delay in 125I-LDL degradation and hydrolysis of 3H-CL was seen in cells treated for 3 to 24 hours with verapamil. 3h-cl 66-71 interleukin 6 Homo sapiens 3-6 32214022-5 2020 Our results indicate that even low concentrations of Pb cause an increase in production of inflammatory interleukins (IL-1beta and IL-6), increases expression of COX-1 and COX-2, and increases thromboxane B2 and prostaglandin E2 concentration in macrophages. Lead 53-55 interleukin 6 Homo sapiens 131-135 32196098-6 2020 Results: Treatment with noncytotoxic concentrations of GS resulted in the dose-dependent inhibition of IL-1beta-induced inflammatory cytokines, including IL-6, IL-8, MCP-1, and COX-2, at both mRNA and protein levels. pregna-4,17-diene-3,16-dione 55-57 interleukin 6 Homo sapiens 154-158 34027995-11 2021 CRP and IL-6 mediated the association between EAA and fatigue (CRP: 95% CI, 0.060-0.279; IL-6: 95% CI, 0.024-0.220). ethyl acetoacetate 46-49 interleukin 6 Homo sapiens 8-12 34027995-11 2021 CRP and IL-6 mediated the association between EAA and fatigue (CRP: 95% CI, 0.060-0.279; IL-6: 95% CI, 0.024-0.220). ethyl acetoacetate 46-49 interleukin 6 Homo sapiens 89-93 34035828-9 2021 Further analysis showed that the HGD activity of quercetin, formononetin, kaempferol, isorhamnetin, and beta-sitosterol ingredients is possible through VEGFA, IL6, TNF, AKT1, and TP53 targets involved in TNF, toll-like receptors, and MAPK-related pathways, which have anti-inflammatory, antiapoptosis, antioxidation, and autophagy effects, relieve renal fibrosis and renal cortex injury, and improve renal function, thus delaying the development of DN. gamma-sitosterol 104-119 interleukin 6 Homo sapiens 159-162 32042418-0 2020 Sulfur-containing amino acids in aged garlic extract inhibit inflammation in human gingival epithelial cells by suppressing intercellular adhesion molecule-1 expression and IL-6 secretion. Sulfur 0-6 interleukin 6 Homo sapiens 173-177 33945347-7 2021 Our results revealed that Evodiamine significantly decreased TNF-alpha, IL-6, and IL-1beta in BEAS-2B cells. evodiamine 26-36 interleukin 6 Homo sapiens 72-76 31785814-5 2020 Interestingly, the combination treatment of VPA and anti-PD-L1 antibody activated IRF1/IRF8 transcriptional axis in MDSCs leading to blockade of their immunosuppressive function by downregulating the expression of IL-10, IL-6, and ARG1 while re-activating CD8+ T-cells for the production of TNFalpha to further enhance anti-tumor immunity. Valproic Acid 44-47 interleukin 6 Homo sapiens 221-225 32955700-8 2021 Subsequent multivariate logistic regression analysis revealed that among these inflammatory cytokines, only IL-6 (P = 0.019) independently predicted higher ASAS 20 response to celecoxib at W12, and it had a fair value for predicting ASAS 20 response to celecoxib at W12 (area under the curve: 0.666, 95% confidence interval: 0.561-0.771) by receiver-operating characteristic curve analysis. Celecoxib 176-185 interleukin 6 Homo sapiens 108-112 31448433-5 2020 Upadacitinib (and tofacitinib) reversibly inhibited IL-6-induced pSTAT3 and IL-7-induced pSTAT5 in a concentration-dependent manner. upadacitinib 0-12 interleukin 6 Homo sapiens 52-56 33962178-6 2021 The impedimetric immunosensor was developed on a BP-PAMI modified laser burned graphene (LBG) to detect interleukin-6 biomarkers using electrochemical impedance spectroscopy (EIS). Graphite 79-87 interleukin 6 Homo sapiens 104-117 32027273-8 2020 At the same time, it acts synergistically with bortezomib, which may be related to mitochondrial pathway, and probably related to the regulating of IL-6, JAK2 and STAT3 gene expression in signal pathway of JAK2/STAT3. bortezomib 47-57 interleukin 6 Homo sapiens 148-152 33890979-8 2021 CD34+ cells from CALR-mutated patients showed increased levels of IL-6 mRNA and p-STAT3, and colony-forming unit-Mk growth was inhibited by either SC144 or TCZ, as well as an IL-6 antibody, supporting cell-autonomous activation of the IL-6 pathway. SC 144 147-152 interleukin 6 Homo sapiens 66-70 33963719-8 2021 Several key targets including AKT1, IL- 6, JUN, TNF and CASP3 were screened for molecular docking, which had good binding activities with berberrubine, epiberberine, stigmasterol and sitosterol. gamma-sitosterol 183-193 interleukin 6 Homo sapiens 36-41 33463223-6 2020 In this work, we hypothesized that new copolymers composed of CPTEG and SA would combine the advantages of both monomers in terms of enhanced thermal properties, maintaining antigenicity of encapsulated proteins following nanoparticle synthesis, and superior cellular internalization and activation by APCs, demonstrated by the upregulation of costimulatory markers CD80, CD86, and CD40, as well as the secretion of proinflammatory cytokines IL-6, IL-1beta, and TNF-alpha. cpteg 62-67 interleukin 6 Homo sapiens 442-446 31764984-6 2021 Tumour necrosis factor-alpha (-20%) and interleukin-6 (-22%) were also reduced with high dialysate Mg treatment (both P < 0.01). Magnesium 99-101 interleukin 6 Homo sapiens 40-53 33936850-4 2021 beta-Glucan was demonstrated to synergistically enhance the VS-stimulated immune response, including the production of interleukin-6, tumor necrosis factor-alpha, and nitric oxide, mainly through the mitogen-activated protein kinase pathway in macrophages. beta-Glucans 0-11 interleukin 6 Homo sapiens 119-132 31971835-11 2020 Al activated extracellular signal-regulated kinase 1/2 and nuclear factor-kappa B (NF-kappaB), resulting in mRNA expression of matrix metalloproteinase-9, myosin light-chain kinase, and inflammatory cytokines [tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6] in HT-29 cells. Aluminum 0-2 interleukin 6 Homo sapiens 285-289 33686490-12 2021 Peak values of IL6, Syndecan-1, sVEGFR1, and sTM all correlated to peak PGI2. Epoprostenol 72-76 interleukin 6 Homo sapiens 15-18 33748269-13 2021 The findings also suggest that several ingredients of ABR such as Baicalien, Copistine, Epiberberine, Kaempferol, and Palmatine have good affinity with IL6, suggesting the promising potential of ABR in treating bone trauma, likely through IL6. copistine 77-86 interleukin 6 Homo sapiens 152-155 31810825-6 2020 RESULTS: Bifidobacteria inhibited LPS- and oleate-induced protein expression of inflammatory cytokines (IL-6, TNF-alpha) concomitantly with decreases in cellular TG and iron concentration. Oleic Acid 43-49 interleukin 6 Homo sapiens 104-108 33516376-0 2021 A novel QCM immunosensor development based on gold nanoparticles functionalized sulfur-doped graphene quantum dot and h-ZnS-CdS NC for Interleukin-6 detection. Graphite 93-101 interleukin 6 Homo sapiens 135-148 33516376-3 2021 A novel quartz crystal microbalance (QCM) immunoassay method was presented for high sensitivity and selectivity detection of interleukin-6 (IL-6) based on gold nanoparticles functionalized sulfur-doped graphene quantum dot (AuNPs/S-GQD) and hollow ZnS-CdS nanocage (h-ZnS-CdS NC). Graphite 202-210 interleukin 6 Homo sapiens 125-138 33516376-3 2021 A novel quartz crystal microbalance (QCM) immunoassay method was presented for high sensitivity and selectivity detection of interleukin-6 (IL-6) based on gold nanoparticles functionalized sulfur-doped graphene quantum dot (AuNPs/S-GQD) and hollow ZnS-CdS nanocage (h-ZnS-CdS NC). Graphite 202-210 interleukin 6 Homo sapiens 140-144 33602249-11 2021 Based on our data, DHA and Insulin diminished the production of all inflammatory cytokines, TNF-alpha, IL-6, and NF-kappaB, in palmitic-treated cells (p < 0.05). Docosahexaenoic Acids 19-22 interleukin 6 Homo sapiens 103-107 33146673-7 2021 RESULTS: The network pharmacology research showed that TCM could decrease IL-6 using several compounds, such as quercetin, ursolic acid, luteolin, and rutin. Rutin 151-156 interleukin 6 Homo sapiens 74-78 33146673-11 2021 Quercetin, ursolic acid, luteolin, and rutin could inhibit COVID-19 by downregulating IL-6. Rutin 39-44 interleukin 6 Homo sapiens 86-90 32341698-7 2020 Analysis of the investigated parameters in the leading group after receiving alpha-lipoic acid for 4 months showed a significant decrease in the concentration of C-Reactive Protein, IL-6 and TNF-alpha. Thioctic Acid 77-94 interleukin 6 Homo sapiens 182-186 33537146-9 2021 Results: Multiplexed cytokine analysis showed rising type I/II IFNs, and IL-6 in BAL post-LTx that decreased following treatment of acute rejection but rebounded with further clinical deterioration. Leukotriene C4 90-93 interleukin 6 Homo sapiens 73-77 32869704-0 2020 Deoxycholic Acid Upregulates the Reprogramming Factors KFL4 and OCT4 Through the IL-6/STAT3 Pathway in Esophageal Adenocarcinoma Cells. kfl4 55-59 interleukin 6 Homo sapiens 81-85 33530554-6 2021 Moreover, polyphenols could modulate microbiota composition, inhibit the NF-kappaB pathway, lower IL-6, and upregulate antioxidant enzymes. Polyphenols 10-21 interleukin 6 Homo sapiens 98-102 31526917-5 2019 CCL2 (p = 0.039), and CCL5 (p = 0.001) levels were significantly higher in fingolimod-treated patients than healthy controls, whereas end-of-study serum levels of IL-6, IL-8, IL-17A, IL-22, IL-23, TNF-alpha, CXCL10, and CXCL13 were comparable to the baseline levels. Fingolimod Hydrochloride 75-85 interleukin 6 Homo sapiens 163-167 33467441-7 2021 Ibrutinib achieves a reduction in the production of TNFalpha, IL1, IL-6 and Monocyte chemo-attractant protein-1 (MCP-1) by neutrophils and macrophages, that are key players in keeping the inflammatory process. ibrutinib 0-9 interleukin 6 Homo sapiens 67-71 33423654-10 2021 Biological importance of poncirin for their anti-inflammatory activity through inhibition of PGE2 and IL-6 production has been investigated in the scientific field. poncirin 25-33 interleukin 6 Homo sapiens 102-106 31174433-8 2019 Lixisenatide inhibits FFA-triggered production of TNF-alpha, IL-6, VCAM-1 and ICAM-1. lixisenatide 0-12 interleukin 6 Homo sapiens 61-65 33520369-5 2021 Mechanistically, cinobufagin simultaneously suppressed the phosphorylation of signal transducer and activator of transcription 3 (STAT3) and blocked the interleukin-6 (IL6)-induced nuclear translocation of STAT3. cinobufagin 17-28 interleukin 6 Homo sapiens 153-166 33520369-5 2021 Mechanistically, cinobufagin simultaneously suppressed the phosphorylation of signal transducer and activator of transcription 3 (STAT3) and blocked the interleukin-6 (IL6)-induced nuclear translocation of STAT3. cinobufagin 17-28 interleukin 6 Homo sapiens 168-171 31515297-11 2019 Notably, combination fenretinide-tocilizumab-reparixin treatment significantly suppressed IL-6 and IL-8 release, stem cell gene expression, and invasion in these diverse CSCE populations. Fenretinide 21-32 interleukin 6 Homo sapiens 90-94 33284859-6 2020 Use of the AT1 receptor antagonist, Candesartan cilexetil, resulted in down-regulation of IL-6/soluble IL-6R release in spike expressing cells. candesartan cilexetil 36-57 interleukin 6 Homo sapiens 90-94 31824305-15 2019 2-HEC, 2-HPC, and GCBD dose-dependently inhibited LPS-induced IL-1beta, TNF-alpha, and IL-6 synthesis. 2-(1-hydroxypentyl)-benzoate 7-12 interleukin 6 Homo sapiens 87-91 33218268-10 2020 In addition, we discovered that the PD-L1 expression promoted by obesity/MetS could be restored by telmisartan, one of the angiotensin II receptor blockers (ARBs) and could affect macrophage polarization, through its selective peroxisome proliferator-activated receptor-gamma (PPARG) activation and NFKB p65 inhibition and therefore downregulates IL6 secretion from M1 macrophage. Telmisartan 99-110 interleukin 6 Homo sapiens 347-350 25905362-12 2000 In the autonomic nervous system, catecholamines have been found to stimulate IL-6 secretion through a beta-adrenergic mechanism showing the immune effects on endocrine system. Catecholamines 33-47 interleukin 6 Homo sapiens 77-81 32949615-10 2020 IL6, TNFalpha,CRP were increased and Apo AI was less while Apo B was increased in OP exposed groups in both population groups SNPs analysis of PON1 showed significant differences in allelic and genotype frequencies of OPs exposed and non-exposed groups. Organophosphates 218-221 interleukin 6 Homo sapiens 0-3 31814911-8 2019 The concentrations of TNF-alpha and IL-6 in cell culture medium of S60 and S30 groups were elevated as compared to S15 and S0 groups (P<0.05). fullerene C60 67-70 interleukin 6 Homo sapiens 36-40 31451183-10 2019 The "C"allele of IL-6 rs1800797 was implicated with higher prevalence of DN (C versus G: P = 0.0001; CC versus GG: P = 0.0003; CC versus GG + CG: P = 0.0227; CC + CG versus GG: P = 0.0001) while IL-6 rs2069837 and rs2069840 were not correlated with the susceptibility to DN. cysteinylglycine 142-144 interleukin 6 Homo sapiens 17-21 32662566-9 2020 beta-TmU had higher IL-8 than their controls while beta-TmN had higher IL-6 and IL-8 than their controls. beta-tmn 51-59 interleukin 6 Homo sapiens 71-75 32916201-7 2020 We found that CCK-8 inhibited METH-induced microglial activation and IL-6 and TNF-alpha generation in vivo and in vitro in a dose-dependent manner. cholecystokinin 8 14-19 interleukin 6 Homo sapiens 69-73 31451183-10 2019 The "C"allele of IL-6 rs1800797 was implicated with higher prevalence of DN (C versus G: P = 0.0001; CC versus GG: P = 0.0003; CC versus GG + CG: P = 0.0227; CC + CG versus GG: P = 0.0001) while IL-6 rs2069837 and rs2069840 were not correlated with the susceptibility to DN. cysteinylglycine 163-165 interleukin 6 Homo sapiens 17-21 33255431-6 2020 IL-6 release was inhibited by P2X7R antagonists A438079, A839977, and AZ10606120, but not the NRTI lamivudine (3TC), P2X1R antagonist NF279, or P2Y1R antagonist MRS2179. A-839977 57-64 interleukin 6 Homo sapiens 0-4 30782093-0 2019 Sphingosine 1 Phosphate (S1P) Increased IL-6 Expression and Cell Growth in Endometriotic Cells. sphingosine 1-phosphate 0-23 interleukin 6 Homo sapiens 40-44 33215957-3 2020 GSSSG prevented the LPS-induced upregulation of interleukin (IL)-1beta, IL-6, and C-C motif chemokine ligand 2 (CCL2) in ARPE-19/primary RPE cells. glutathione trisulfide 0-5 interleukin 6 Homo sapiens 72-76 33215957-5 2020 ERK1/2 inhibition prevented the GSSSG-mediated inhibition of LPS-induced IL-6 and CCL2 upregulation. glutathione trisulfide 32-37 interleukin 6 Homo sapiens 73-77 30782093-10 2019 JTE013, an antagonist for S1PR2, partially suppressed IL-6 induction by S1P ( P < .05). JTE 013 0-6 interleukin 6 Homo sapiens 54-58 33061298-11 2020 Results: The presence of Linagliptin significantly reduced ox-LDL-induced cytokine production (IL-1beta and IL-6) and ROS production. Linagliptin 25-36 interleukin 6 Homo sapiens 108-112 31165327-10 2019 In conclusion, combination of resveratrol and silymarin could significantly inhibit inflammatory effects of histamine on cultured HGFs by reduction of IL-6, IL-8, TPA-1, and TNF-alpha. Silymarin 46-55 interleukin 6 Homo sapiens 151-155 31383729-12 2019 Collectively, this study demonstrates that the anti-inflammatory properties of THC suppress TLR7-induced monocyte secretion of IL-1beta through CB2, which results in decreased astrocyte secretion of MCP-1 and IL-6. Dronabinol 79-82 interleukin 6 Homo sapiens 209-213 32977686-9 2020 Finally, the inflammatory response in the HGF-1 cells after their exposure to GSH-AgNPs was measured as the production of immune markers (interleukins 6 and 8 (IL-6 and IL-8) and tumor necrosis factor-alpha (TNF-alpha)). gsh-agnps 78-87 interleukin 6 Homo sapiens 138-158 32977686-9 2020 Finally, the inflammatory response in the HGF-1 cells after their exposure to GSH-AgNPs was measured as the production of immune markers (interleukins 6 and 8 (IL-6 and IL-8) and tumor necrosis factor-alpha (TNF-alpha)). gsh-agnps 78-87 interleukin 6 Homo sapiens 160-164 31348843-10 2019 Prostate cancer cells increased the expression of interleukin1beta (IL1beta), IL10, and IL6 in monocytes which was inhibited by galiellalactone. galiellalactone 128-143 interleukin 6 Homo sapiens 88-91 32645629-7 2020 We found that DMF significantly improved cell viability and reduced the expression of pro-inflammatory cytokines and chemokines, including IL-6, IL-8, and MCP-1. Dimethyl Fumarate 14-17 interleukin 6 Homo sapiens 139-143 31872639-11 2019 Compared with IR model group,wogonoside not only inhibited the protein expression of inflammatory nuclear transcriptional factors NLRP3,SOCS3,TLR4,NF-kappaB,but also decreased the expression of downstream inflammatory effect factors IL-1beta,IL-6 and TNF-alpha. wogonoside 29-39 interleukin 6 Homo sapiens 242-246 32922141-0 2020 Aliskiren, tadalafil, and cinnamaldehyde alleviate joint destruction biomarkers; MMP-3 and RANKL; in complete Freund"s adjuvant arthritis model: Downregulation of IL-6/JAK2/STAT3 signaling pathway. aliskiren 0-9 interleukin 6 Homo sapiens 163-167 32922141-0 2020 Aliskiren, tadalafil, and cinnamaldehyde alleviate joint destruction biomarkers; MMP-3 and RANKL; in complete Freund"s adjuvant arthritis model: Downregulation of IL-6/JAK2/STAT3 signaling pathway. cinnamaldehyde 26-40 interleukin 6 Homo sapiens 163-167 32922141-7 2020 Treatment with cinnamaldehyde, tadalafil, or aliskiren reduced serum levels of rheumatoid factor, and pro-inflammatory cytokines; tumor necrosis factor-alpha and interleukin-6 (IL-6), along with elevated level of IL-10 which is an anti-inflammatory cytokine. cinnamaldehyde 15-29 interleukin 6 Homo sapiens 162-175 32922141-7 2020 Treatment with cinnamaldehyde, tadalafil, or aliskiren reduced serum levels of rheumatoid factor, and pro-inflammatory cytokines; tumor necrosis factor-alpha and interleukin-6 (IL-6), along with elevated level of IL-10 which is an anti-inflammatory cytokine. cinnamaldehyde 15-29 interleukin 6 Homo sapiens 177-181 31554244-6 2019 Finally, we present preliminary data showing that the cytokine IL-6 cross talks with activation of the c-Jun N-terminal kinase pathway in response to heme-hemopexin in models of hepatocytes. Heme 150-154 interleukin 6 Homo sapiens 63-67 30541065-3 2019 Angiotensin receptor blockers and omega-3 polyunsaturated fatty acids (omega-3) may reduce IL-6 and may potentially improve physical function. omega-3 34-41 interleukin 6 Homo sapiens 91-95 31437155-4 2019 Linear mixed effects models were used to determine whether heavy drinking (self-report augmented by phosphatidylethanol [PEth], an alcohol biomarker) was longitudinally associated with IL-6, sCD14 and D-dimer adjusting for potential confounders (e.g., demographics, HIV factors, comorbid conditions). phosphatidylethanol 100-119 interleukin 6 Homo sapiens 185-189 2472117-2 1989 The relative positions of four half-cystines in human interleukin-6 (IL-6) match four of the five in human granulocyte colony stimulating factor. Cystine 36-44 interleukin 6 Homo sapiens 54-67 2472117-2 1989 The relative positions of four half-cystines in human interleukin-6 (IL-6) match four of the five in human granulocyte colony stimulating factor. Cystine 36-44 interleukin 6 Homo sapiens 69-73 31437155-4 2019 Linear mixed effects models were used to determine whether heavy drinking (self-report augmented by phosphatidylethanol [PEth], an alcohol biomarker) was longitudinally associated with IL-6, sCD14 and D-dimer adjusting for potential confounders (e.g., demographics, HIV factors, comorbid conditions). phosphatidylethanol 121-125 interleukin 6 Homo sapiens 185-189 30836837-8 2019 Post-race catecholamine levels explained 60% of the variance in the IL-6 response (r = 0.77, p = 0.040), which was further increased when the resting autonomic function indices were added to the regression model (R2 > 81%, p < 0.012). Catecholamines 10-23 interleukin 6 Homo sapiens 68-72 2731990-4 1989 By measuring IL-1 TNF-alpha, and IL-6, the interaction of different LPSs or lipid A with human serum could be shown to prevent the activation of human monocytes. lpss 68-72 interleukin 6 Homo sapiens 33-37 31244012-5 2019 Anionic PEI-DGAs induce the secretion of proinflammatory cytokines IL-1beta, TNFalpha, and IL-6 in macrophages and MSCs, whereas cationic PEI-DGAs do not. pei-dgas 8-16 interleukin 6 Homo sapiens 91-95 6440265-6 1984 This behavior of G6PD-deficient HL and HSF is coupled with an increase of the resistance to the cell death induced by benzo(a)pyrene (BP). Benzo(a)pyrene 118-132 interleukin 6 Homo sapiens 39-42 6440265-6 1984 This behavior of G6PD-deficient HL and HSF is coupled with an increase of the resistance to the cell death induced by benzo(a)pyrene (BP). Benzo(a)pyrene 134-136 interleukin 6 Homo sapiens 39-42 6440265-7 1984 This effect is mimicked by the incubation of normal HSF with dehydroepiandrosterone (DEA) which strongly inhibits G6PD. Dehydroepiandrosterone 61-83 interleukin 6 Homo sapiens 52-55 6440265-7 1984 This effect is mimicked by the incubation of normal HSF with dehydroepiandrosterone (DEA) which strongly inhibits G6PD. Dehydroepiandrosterone 85-88 interleukin 6 Homo sapiens 52-55 30593845-9 2019 Addition of miR-26b-5p contributed to secretion of tumor necrosis factor alpha (TNF-alpha), interferon-gamma (IFN-gamma), interleukin-6 (IL-6) and IL-2 in CD4+ and CD8+ cells. mir-26b-5p 12-22 interleukin 6 Homo sapiens 122-135 32856190-7 2021 The changes of interleukin-1beta levels in the FA group and interleukin-6 levels in the DHA group were significantly less than that in the FA + DHA group (P < 0.05). Docosahexaenoic Acids 88-91 interleukin 6 Homo sapiens 60-73 33998910-5 2021 There is accumulating evidence that dietary polyphenols may show therapeutic efficacy in RA through their antioxidant, anti-inflammatory, apoptotic, and immunosuppressant activities and modulation of the tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, mitogen-activated protein kinase (MAPK), IL-1beta, c-Jun N-terminal kinase (JNK), and nuclear factor kappa light-chain-enhancer of activated B cell (NF-kappaB) pathways. Polyphenols 44-55 interleukin 6 Homo sapiens 245-263 30593845-9 2019 Addition of miR-26b-5p contributed to secretion of tumor necrosis factor alpha (TNF-alpha), interferon-gamma (IFN-gamma), interleukin-6 (IL-6) and IL-2 in CD4+ and CD8+ cells. mir-26b-5p 12-22 interleukin 6 Homo sapiens 137-141 31439177-3 2019 IL-6 screening of patients with TB may be useful to monitor the progress of infection and to infer the risk of progression to active disease. Terbium 32-34 interleukin 6 Homo sapiens 0-4 34025070-14 2021 In vivo, SB2035080 attenuated lung histopathological injury, decreased inflammatory activity (TNF-alpha, IL-1beta, IL-6 and myeloperoxidase) and preserved pulmonary function. sb2035080 9-18 interleukin 6 Homo sapiens 115-139 32955700-8 2021 Subsequent multivariate logistic regression analysis revealed that among these inflammatory cytokines, only IL-6 (P = 0.019) independently predicted higher ASAS 20 response to celecoxib at W12, and it had a fair value for predicting ASAS 20 response to celecoxib at W12 (area under the curve: 0.666, 95% confidence interval: 0.561-0.771) by receiver-operating characteristic curve analysis. Celecoxib 253-262 interleukin 6 Homo sapiens 108-112 32955700-9 2021 CONCLUSION: Serum IL-1beta, IL-6, and IL-17A serve as indicators for predicting clinical response to celecoxib in AS patients, which may assist with the optimization of personalized treatment. Celecoxib 101-110 interleukin 6 Homo sapiens 28-32 31059018-7 2019 Additionally, KYS05090S blocked the nuclear translocation of STAT3 and suppressed the signaling of JAK2/STAT3 in interleukin-6-treated SKOV3 cells, as a STAT3 activator. KYS 05090 14-23 interleukin 6 Homo sapiens 113-126 33846227-7 2021 However, at the output of the nucleus, the combination of M-triDAP and LPS synergistically induces expression of a subset of M-triDAP- and LPS-inducible genes, particularly those encoding proinflammatory cytokines (TNF, IL1B, IL6, IL12B, and IL23A). L-Ala-gamma-D-Glu-meso-diaminopimelic acid 59-66 interleukin 6 Homo sapiens 226-229 33981768-6 2021 The MAPK signaling inhibitor, aloesin, partially reversed the effects of IL-6 on MDSCs. aloesin 30-37 interleukin 6 Homo sapiens 73-77 31115521-8 2019 Additionally, IL-6-induced activation of STAT3 target genes (e.g. MCL-1 and BCL-2) was attenuated by TP and homoharringtonine. Homoharringtonine 108-125 interleukin 6 Homo sapiens 14-18 33849824-7 2021 Amentoflavone down-regulated the mRNA expressions of IL-6 and TNF-alpha, up-regulated mRNA expressions of IL-8 and TGF-beta mRNA (P < 0.05), and increased the protein expressions of PPAR-alpha/gamma, Arg-1 and Fizz1. amentoflavone 0-13 interleukin 6 Homo sapiens 53-57 31234944-9 2019 Mechanistically, the JAK2/STAT3 pathway was enhanced by EREG in parallel with increased IL-6 expression, which could be inhibited by the JAK2 inhibitor AG490. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 152-157 interleukin 6 Homo sapiens 88-92 33753770-4 2021 LLL12B selectively inhibited the induction of STAT3 phosphorylation by interleukin-6 but not induction of STAT1 phosphorylation by INF-gamma. lll12b 0-6 interleukin 6 Homo sapiens 71-84 31186039-0 2019 Ilamycin C induces apoptosis and inhibits migration and invasion in triple-negative breast cancer by suppressing IL-6/STAT3 pathway. ilamycin c 0-10 interleukin 6 Homo sapiens 113-117 29382220-6 2019 It was found that gracicleistanthoside (5) and uridine (7) remarkably down-regulated the TNF-alpha-induced synthesis of interleukin-6 (IL-6), a pro-inflammatory cytokine associated with cutaneous inflammation, in HaCaT cells. Gracicleistanthoside 18-38 interleukin 6 Homo sapiens 120-133 33448324-4 2021 The results revealed that miR-101-3p was upregulated in the serum of patients with sepsis-induced cardiomyopathy (SIC) and positively correlated with the levels of pro-inflammatory cytokines (including IL-1beta, IL-6 and TNF-alpha). mir-101-3p 26-36 interleukin 6 Homo sapiens 212-216 29382220-6 2019 It was found that gracicleistanthoside (5) and uridine (7) remarkably down-regulated the TNF-alpha-induced synthesis of interleukin-6 (IL-6), a pro-inflammatory cytokine associated with cutaneous inflammation, in HaCaT cells. Gracicleistanthoside 18-38 interleukin 6 Homo sapiens 135-139 33544929-7 2021 The 18Co-CM-induced increase in CD133+CD44+ cells was attenuated by IL-6- and IL-8-neutralizing antibodies. 18co 4-8 interleukin 6 Homo sapiens 68-72 30945979-8 2019 Preoperative IL-6 levels were not different between the two groups, but the rise (pre- versus postoperative) of IL-6 in the SPLA group was remarkably higher when compared with the 3PLA group (P < .05). spla 124-128 interleukin 6 Homo sapiens 112-116 33639877-13 2021 Eyes with FUS had significantly higher aqueous humor (AH) cytokine levels (VEGF, bFGF, IL-6, IL-8 and IL-10) compared with the control eyes (P < 0.05). fusarubin 10-13 interleukin 6 Homo sapiens 87-91 30843693-6 2019 The Pearson"s correlation coefficient test elucidated that inorganics (EC), organics (OC, PAHs, and alkane), and metals (Cr, Mn, and Sb) were significantly correlated to the dysregulated oncoproteins (VEGF, IL6, MDM2, AKT1, STAT, and P53). Chromium 121-123 interleukin 6 Homo sapiens 207-210 33672354-8 2021 Celecoxib and dexamethasone-loaded nanoparticles reduced the release of different inflammatory mediators (NO, TNF-alpha, IL-1beta, IL-6, PGE2 and IL-10) by lipopolysaccharide (LPS)-stimulated RAW264.7. Celecoxib 0-9 interleukin 6 Homo sapiens 131-135 30721699-3 2019 Our objective in this meta-analysis was to conduct a systematic review and meta-analysis on randomized controlled trials to indicate ALA effects on serum inflammatory mediators concentration such as tumor necrosis factor-alpha (TNF-alpha), c-reactive protein (CRP), and interleukin-6 (IL-6). Thioctic Acid 133-136 interleukin 6 Homo sapiens 270-283 33679785-9 2021 Further analysis showed that monocytes secrete TNF-alpha, IL-6, and IL-10 upon beta-glucan addition. beta-Glucans 79-90 interleukin 6 Homo sapiens 58-62 30721699-3 2019 Our objective in this meta-analysis was to conduct a systematic review and meta-analysis on randomized controlled trials to indicate ALA effects on serum inflammatory mediators concentration such as tumor necrosis factor-alpha (TNF-alpha), c-reactive protein (CRP), and interleukin-6 (IL-6). Thioctic Acid 133-136 interleukin 6 Homo sapiens 285-289 30831022-6 2019 IL-6 was significantly correlated with HULIS (as the main fraction of WSOC with oxygenated carbohydrate structures characteristic), Pb, and endotoxin. Lead 132-134 interleukin 6 Homo sapiens 0-4 33593885-13 2021 OPN, HGF, TIMP-1, VCAM-1, PDGF-AA and IL-6 levels increased with progression on everolimus, while OPN, PlGF, TIMP-1, VEGF, and soluble VEGFR-2 and VCAM-1 increased with progression on sunitinib. Everolimus 80-90 interleukin 6 Homo sapiens 38-42 31019654-7 2019 DHTS deregulated the dynamic equilibrium from non-stem cancer cells to CSCs by dephosphorylating Stat3 and decreasing IL-6 secretion and inhibiting CSC formation. dhts 0-4 interleukin 6 Homo sapiens 118-122 31019654-8 2019 These novel findings showed that DHTS-induced ROS deregulated the Stat3/IL-6 pathway and induced CSC death. dhts 33-37 interleukin 6 Homo sapiens 72-76 31019654-9 2019 NOX5 activation by DHTS inhibits CSC formation through ROS/Stat3/IL-6 signaling, and DHTS may be a promising potential therapeutic agent against breast CSCs. dhts 19-23 interleukin 6 Homo sapiens 65-69 32255011-0 2019 Bead-type polystyrene/nano-CaCO3 (PS/nCaCO3) composite: a high-performance adsorbent for the removal of interleukin-6. Polystyrenes 10-21 interleukin 6 Homo sapiens 104-117 30846730-9 2019 In addition to the angiogenesis-promoting action of PC, it also showed anti-inflammatory activity by reducing TNF-alpha-mediated IL-1beta and IL-6 expression. pc 52-54 interleukin 6 Homo sapiens 142-146 30835597-6 2019 Moreover, carnitine and chromium co-supplementation upregulated gene expression of interleukin-6 (IL-6) (p = 0.02) and tumor necrosis factor alpha (TNF-alpha) (p = 0.02) compared with the placebo. Chromium 24-32 interleukin 6 Homo sapiens 83-96 30835597-6 2019 Moreover, carnitine and chromium co-supplementation upregulated gene expression of interleukin-6 (IL-6) (p = 0.02) and tumor necrosis factor alpha (TNF-alpha) (p = 0.02) compared with the placebo. Chromium 24-32 interleukin 6 Homo sapiens 98-102 30835597-7 2019 CONCLUSION: Overall, the co-administration of carnitine and chromium for 12 weeks to women with PCOS had beneficial effects on mental health parameters, serum total testosterone, mF-G scores, hs-CRP, TAC and MDA levels, and gene expression of IL-6 and TNF-alpha. Chromium 60-68 interleukin 6 Homo sapiens 243-247 28817438-11 2019 Mechanistically, we show that macrophages recruited to burn-stressed subcutaneous WAT (sWAT) undergo alternative activation to induce tyrosine hydroxylase expression and catecholamine production mediated by IL-6, factors required for browning of sWAT. Catecholamines 170-183 interleukin 6 Homo sapiens 207-211 32307149-9 2020 The present results introduce the cytokines IL-6 and IL-10 in patients before and after LTx. Leukotriene C4 88-91 interleukin 6 Homo sapiens 44-48 32445015-12 2020 A significant increase in activation of NF-kappaB and production of pro-inflammatory cytokines IL-6 and IL-8 was observed after treatment with 4-HNE. 4-hydroxy-2-nonenal 143-148 interleukin 6 Homo sapiens 95-99 30823952-12 2019 CONCLUSION: Compared with inhaled glucocorticoid, inhaled glucocorticoid combined with tiotropium bromide treatment can more effectively reduce the serum levels of hs-CRP and IL-6 and is beneficial to control the development of ACOS. Tiotropium Bromide 87-105 interleukin 6 Homo sapiens 175-179 32141013-12 2020 Molecular docking analysis demonstrated strong binding interaction of amlodipine with TNF-alpha, IL-6 and IL-1beta thus providing a good correlation between experimental and theoretical results. Amlodipine 70-80 interleukin 6 Homo sapiens 97-101 30842737-10 2019 GYY4137 and ATB-346 significantly reduced the IM-induced increase in muscular myeloperoxidase (MPO) activity and protein levels of interleukin (IL)-6, IL-1beta and monocyte chemotactic protein 1; the reduction by naproxen was less pronounced and only reached significance for MPO activity and IL-6 levels. 4-anisyltetrazolium blue 12-15 interleukin 6 Homo sapiens 293-297 32170601-4 2020 Primed with oat beta-glucan, the mRNA expression and production of TNF-alpha and IL-6 significantly increased in response to re-stimulation of TLR-4/2 ligands. beta-Glucans 16-27 interleukin 6 Homo sapiens 81-85 30781671-6 2019 Zerumbone has shown its anti-cancer effects by causing significant suppression of proliferation, survival, angiogenesis, invasion, and metastasis through the molecular modulation of different pathways such as NF-kappaB, Akt, and IL-6/JAK2/STAT3 (interleukin-6/janus kinase-2/signal transducer and activator of transcription 3) and their downstream target proteins. zerumbone 0-9 interleukin 6 Homo sapiens 229-233 32170601-6 2020 In addition, inhibiting these enzymes decreased the production of TNF-alpha and IL-6 boosted by oat beta-glucan. beta-Glucans 100-111 interleukin 6 Homo sapiens 80-84 32802081-16 2020 Losartan decreased the release of IL-6 from MSCs. Losartan 0-8 interleukin 6 Homo sapiens 34-38 30781671-6 2019 Zerumbone has shown its anti-cancer effects by causing significant suppression of proliferation, survival, angiogenesis, invasion, and metastasis through the molecular modulation of different pathways such as NF-kappaB, Akt, and IL-6/JAK2/STAT3 (interleukin-6/janus kinase-2/signal transducer and activator of transcription 3) and their downstream target proteins. zerumbone 0-9 interleukin 6 Homo sapiens 246-259 30547263-6 2019 However, in the absence of LPS, IL-6 secretion was significantly increased in response to 2 microM of either cyanidin or chlorogenic acid (both p < 0.0001), as well as the combination treatment (p < 0.01). cyanidin 109-117 interleukin 6 Homo sapiens 32-36 32765941-5 2020 Since PGE2, LXA4 and their precursors AA (arachidonic acid), dihomo-gamma-linolenic acid (DGLA) and gamma-linolenic acid (GLA) inhibit the production of pro-inflammatory IL-6 and TNF-alpha, they could be employed to treat cytokine storm seen in COVID-19, immune check point inhibitory (ICI) therapy, sepsis and ARDS (acute respiratory disease). gamma-Linolenic Acid 68-88 interleukin 6 Homo sapiens 170-174 32635612-5 2020 In cord blood, lower serum levels of both DHA (correlation coefficient -0.40; P = 0.010) and AA (correlation coefficient -0.54; p < 0.001) correlated with higher levels of IL-6. Docosahexaenoic Acids 42-45 interleukin 6 Homo sapiens 172-176 30544066-6 2019 Our results showed that administration of GA significantly increased the expressions of IL-4, and IL-10, while down-regulated IL-1, IL-6, IL-12, IL-17, IL-23, TGF-beta and TNF-alpha expressions compared with a model control group in vitro and in vivo. Gallic Acid 42-44 interleukin 6 Homo sapiens 132-136 31913874-0 2020 Low levels of serum vitamin D in clozapine-treated schizophrenia patients are associated with high levels of the proinflammatory cytokine IL-6. Clozapine 33-42 interleukin 6 Homo sapiens 138-142 30887922-4 2019 At a dose as low as 1- 5 mg per day, naltrexone demonstrates immunomodulatory action i.e. modulates Toll-like receptors signaling, decreases release of proinflammatory cytokines (tumor necrosis factor, interleukin-6, interleukin- 12), inhibits T lymphocyte proliferation, down-regulates the expression of chemokine receptors and adhesion molecules. Naltrexone 37-47 interleukin 6 Homo sapiens 202-215 31913874-10 2020 These results suggest that within clozapine-treated schizophrenia patients, high levels of vitamin D are associated with lower serum levels of the proinflammatory cytokine IL-6. Clozapine 34-43 interleukin 6 Homo sapiens 172-176 31927748-11 2020 There were significant positive correlations between IL-6, IL-8, and CAS, and negative correlation was found between IL-6 level and TED duration before methylprednisolone treatment. Methylprednisolone 152-170 interleukin 6 Homo sapiens 117-121 31336542-6 2019 IL-6 levels correlated with pre-pregnancy body mass index (BMI), fasting blood sugar (FBS) and postprandial sugar (PPBS). Sugars 79-84 interleukin 6 Homo sapiens 0-4 32058033-9 2020 EPA and DHA also significantly lowered production of monocyte chemoattractant protein 1, interleukin (IL)-6 and IL-8. Docosahexaenoic Acids 8-11 interleukin 6 Homo sapiens 89-107 31916050-8 2020 In summary, the study demonstrates that Y-27632 exerts ameliorative effects on colonic inflammation mediated through dual inhibition of the NF-kappaB and IL-6/STAT3 pathways and thus is likely to function as a prospective novel treatment for human ulcerative colitis (UC). Y 27632 40-47 interleukin 6 Homo sapiens 154-158 32029577-10 2020 Cin significantly inhibited IL-1beta-induced interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-alpha (TNF-alpha) release from human synoviocyte cells. cinnamaldehyde 0-3 interleukin 6 Homo sapiens 60-64 32029577-11 2020 The molecular analysis revealed that Cin impaired IL-6-induced janus kinase 2 (JAK2), signal transducer and activator of transcription 1 (STAT1) and STAT3 signaling pathway by inhibiting the phosphorylation of JAK2, STAT1 and STAT3, without affecting NF-kappaB pathway. cinnamaldehyde 37-40 interleukin 6 Homo sapiens 50-54 32319499-0 2020 Correction: Large-sized graphene oxide synergistically enhances parenchymal hepatocyte IL-6 expression monitored by dynamic imaging. graphene oxide 24-38 interleukin 6 Homo sapiens 87-91 32319499-1 2020 Correction for "Large-sized graphene oxide synergistically enhances parenchymal hepatocyte IL-6 expression monitored by dynamic imaging" by Yulong Zhang et al., Nanoscale, 2020, DOI: 10.1039/C9NR10713D. graphene oxide 28-42 interleukin 6 Homo sapiens 91-95 32357521-7 2020 TC-E dramatically reduced lipopolysaccharide (LPS)-induced NO production and the expression of inflammatory genes (inducible NO synthase (iNOS), cyclooxygenase (COX)-2, tumor necrosis factor (TNF)-alpha and interleukin (IL)-6) as determined using RT-PCR. Trichloroethylene 0-4 interleukin 6 Homo sapiens 207-225 32271889-13 2020 Cis-UCA decreased the release of IL-6, IL-8, and LDH in a time-dependent manner when administered to HCE-2 cells after UV-B exposure. cis-Urocanic acid 0-7 interleukin 6 Homo sapiens 33-37 32041779-4 2020 PolyP up-regulated LPS-induced production of the inflammatory cytokines, such as tumor necrosis factor alpha, interleukin-1beta, and interleukin-6, in macrophages, and the effect was polyP dose- and chain length-dependent. poly If 0-5 interleukin 6 Homo sapiens 133-146 32032644-0 2020 Honokiol: A polyphenol neolignan ameliorates pulmonary fibrosis by inhibiting TGF-beta/Smad signaling, matrix proteins and IL-6/CD44/STAT3 axis both in vitro and in vivo. Polyphenols 12-22 interleukin 6 Homo sapiens 123-127 31655158-10 2020 Antagonism of IL-6 signaling by SC144 in vitro led to blockade of IL-6 mediated effects on CD4+ T cells. SC 144 32-37 interleukin 6 Homo sapiens 14-18 31655158-10 2020 Antagonism of IL-6 signaling by SC144 in vitro led to blockade of IL-6 mediated effects on CD4+ T cells. SC 144 32-37 interleukin 6 Homo sapiens 66-70 32005665-8 2020 In hypoxia mimicked by treating MDM with oligomycin (a mitochondrial ATP synthase inhibitor), both 2-DG and glucose starvation strongly suppress TNF and interleukin-6 production, and compromise cell viability. Deoxyglucose 99-103 interleukin 6 Homo sapiens 153-166 32271462-7 2020 Myo-Inositol proved to reduce IL-6 levels in a number of conditions and to mitigate the inflammatory cascade, while being devoid of any significant side effects. Inositol 0-12 interleukin 6 Homo sapiens 30-34 31790890-11 2020 A significant difference in nicotinamide adenine dinucleotide phosphate oxidase 2 concentrations was observed between T0 and T2 only in ADPKD patients treated with ALA (P = 0.039, P = 0.039; respectively), although we did not find a significant difference in interleukin-6, interleukin -1beta, and tumor necrosis factor-alpha concentrations in either group. nicotinamide adenine 28-48 interleukin 6 Homo sapiens 259-272 32088688-0 2020 Prediction of sofosbuvir response using interleukin-6 serum level and single nucleotide polymorphism of interferon lambda- 4. Sofosbuvir 14-24 interleukin 6 Homo sapiens 40-53 31964393-7 2020 Compared to free Bud solution, EAC-Bud-Lip achieved a higher drug uptake in Caco-2 cells and exhibited a stronger inhibition of TNF-alpha and IL-6 secretion in LPS-stimulated Raw264.7 cells. Budesonide 17-20 interleukin 6 Homo sapiens 142-146 31964393-7 2020 Compared to free Bud solution, EAC-Bud-Lip achieved a higher drug uptake in Caco-2 cells and exhibited a stronger inhibition of TNF-alpha and IL-6 secretion in LPS-stimulated Raw264.7 cells. Budesonide 35-38 interleukin 6 Homo sapiens 142-146 31493774-5 2020 RESULTS: IL-6 (beta = -0.136) and VEGF (beta = -0.099) were associated with TBLH BMC, while TNF-alpha (beta = -0.345) and IL-1beta (beta = 0.212) were associated with LS BMC (P < 0.05). tblh bmc 76-84 interleukin 6 Homo sapiens 9-13 32248168-7 2020 The level of IL-6 has significantly decreased, both with the administration of olmesartan (2.7 times) and telmisartan (2.6 times) (p<0.01). olmesartan 79-89 interleukin 6 Homo sapiens 13-17 32248168-7 2020 The level of IL-6 has significantly decreased, both with the administration of olmesartan (2.7 times) and telmisartan (2.6 times) (p<0.01). Telmisartan 106-117 interleukin 6 Homo sapiens 13-17 32248168-9 2020 Telmisartan improves the cardio-metabolic profile of obese and hypertensive patients by increase of adiponectin concentrations and decrease of IL-6 levels. Telmisartan 0-11 interleukin 6 Homo sapiens 143-147 31906036-10 2019 These findings not only provide H2AFJ as a biomarker to predict TMZ therapeutic effectiveness but also suggest a new strategy to combat TMZ-insensitive GBM by targeting the interaction network constructed by TNF-alpha/NF-kappaB, IL-6/STAT3, HDAC3, and H2AFJ. temozolomide 64-67 interleukin 6 Homo sapiens 229-233 31906036-10 2019 These findings not only provide H2AFJ as a biomarker to predict TMZ therapeutic effectiveness but also suggest a new strategy to combat TMZ-insensitive GBM by targeting the interaction network constructed by TNF-alpha/NF-kappaB, IL-6/STAT3, HDAC3, and H2AFJ. temozolomide 136-139 interleukin 6 Homo sapiens 229-233 31407195-12 2019 The levels of plasma inflammatory markers were significantly decreased in BA group after 7 days of intervention in TNF-alpha, IL-1beta, IL-6, IL-8, and PGE2. boswellic acid 74-76 interleukin 6 Homo sapiens 136-140 31849646-7 2019 Ulinastatin also decreased the serum levels of IL-6 (MD = -88.5, 95% CI [-123.97, -53.04], p < 0.00001), TNF-alpha (MD = -56.22, 95% CI [-72.11, -40.33], p < 0.00001), and increased the serum levels of IL-10 (MD = 37.73, 95% CI [16.92, 58.54], p = 0.0004). ulinastatin 0-11 interleukin 6 Homo sapiens 47-51 31323583-7 2019 We found that DEHP at the indicated concentration plus 50.00muM BaP increased cellular and mitochondrial ROS levels, IL-6 and IL-8 secretions at 24 and 48h as well as MDA levels and GSH-Px activities at 48h, compared to the solvent control. Benzo(a)pyrene 64-67 interleukin 6 Homo sapiens 117-121 31499034-6 2019 Molecular analysis revealed that intracellular HSP70 inhibited 4-HNE-induced production of pro-inflammatory cytokines, and 4-HNE exerted proinflammatory effects in RPE cells by enhancing extracellular release of HSP70, as efflux inhibitor Methyl-beta-cyclodextrin (MBC) treatment significantly blocked the release of HSP70 and decreased IL-6 production of RPE cells induced by 4-HNE. 4-hydroxy-2-nonenal 63-68 interleukin 6 Homo sapiens 337-341 31499034-6 2019 Molecular analysis revealed that intracellular HSP70 inhibited 4-HNE-induced production of pro-inflammatory cytokines, and 4-HNE exerted proinflammatory effects in RPE cells by enhancing extracellular release of HSP70, as efflux inhibitor Methyl-beta-cyclodextrin (MBC) treatment significantly blocked the release of HSP70 and decreased IL-6 production of RPE cells induced by 4-HNE. 4-hydroxy-2-nonenal 123-128 interleukin 6 Homo sapiens 337-341 31652453-10 2019 NLRP3 inflammatory body and TXNIP were activated by ketamine, which was supported by the changes in TNF-alpha, IL-6, IL-1 and IL-18 in vivo and in vitro. Ketamine 52-60 interleukin 6 Homo sapiens 111-115 31667008-6 2019 Results: Treatment with IL-6 for 48 hours significantly increased the diffusion rate of FITC-dextran, decreased TEER, and disrupted the distribution of ZO-1 in ARPE-19 cells, which constitutively express the IL-6 transmembrane receptor, and this was reversed with IL-6R blockade. Fluorescein-5-isothiocyanate 88-92 interleukin 6 Homo sapiens 24-28 31615122-1 2019 The novel exchange protein activated by cyclic AMP (EPAC1) activator, I942, induces expression of the suppressor of cytokine signalling 3 (SOCS3) gene, thereby inhibiting interleukin 6 (IL6) inflammatory processes in human umbilical vein endothelial cells (HUVECs). CHEMBL4534834 70-74 interleukin 6 Homo sapiens 171-184 31615122-1 2019 The novel exchange protein activated by cyclic AMP (EPAC1) activator, I942, induces expression of the suppressor of cytokine signalling 3 (SOCS3) gene, thereby inhibiting interleukin 6 (IL6) inflammatory processes in human umbilical vein endothelial cells (HUVECs). CHEMBL4534834 70-74 interleukin 6 Homo sapiens 186-189 31162616-13 2019 Meanwhile, the IBDV-induced mRNA expression levels of IL-6, IFNbeta, and IRF7 were suppressed by betaine consumption. Betaine 97-104 interleukin 6 Homo sapiens 54-58 31162616-14 2019 Furthermore, the hypomethylation effects of IBDV infection to the promoter regions of IL-6 and IRF7 genes were eliminated and relieved by betaine administration. Betaine 138-145 interleukin 6 Homo sapiens 86-90 31700876-9 2019 PQQ can significantly reverse this phenomenon, as evidenced by the decreased levels of proinflammatory cytokines IL-6, IL-1beta and TNF-alpha. PQQ Cofactor 0-3 interleukin 6 Homo sapiens 113-117 31387194-6 2019 BP up-regulated anti-oxidant (NQO1, Txnrd1, Nrf2) and down-regulated inflammatory (TNF-alpha and IL-6) mRNA expressions, in accompany with MAPK signaling inhibition. Benzo(a)pyrene 0-2 interleukin 6 Homo sapiens 97-101 33586783-14 2021 GCF IL-1beta and IL-6 levels were reduced by both doses of ST266 at Day 12 (p<0.05, p<0.01, respectively). st266 59-64 interleukin 6 Homo sapiens 17-21 33586783-15 2021 IL-6 was also significantly reduced in plasma of both ST266 groups (p<0.05). st266 54-59 interleukin 6 Homo sapiens 0-4 33786372-5 2021 Molecular-level investigations reveal that MXene exhibits a strong chemisorption mechanism for immobilizing cytokine interleukin-6 molecules, which is different from activated carbon absorbents. mxene 43-48 interleukin 6 Homo sapiens 117-130 33861459-7 2021 Treatment with MgSO4 results in a significant reduction in serum levels of NGAL, Hb, T.Bill, IL-6, IL-8, SNSE, S100B, EGF, PAF, CRP and IgG. Magnesium Sulfate 15-20 interleukin 6 Homo sapiens 93-97 33861459-9 2021 Moreover, reduction of IL-6, IL-8, SNSE, EGF and APACHE score and increase in RASS score were significantly higher in MgSO4 group compared with placebo. Magnesium Sulfate 118-123 interleukin 6 Homo sapiens 23-27 33303222-5 2021 EPA lowered TNFA (p < 0.001) whereas DHA reduced TNFA (p < 0.001), IL6 (p < 0.02), MCP1 (p < 0.03), and IL10 (p < 0.01). Docosahexaenoic Acids 37-40 interleukin 6 Homo sapiens 67-70 33142636-5 2021 Three NPs greatly promoted the expression and secretion of interleukin-6 (IL-6), tumor necrosis factor (TNF-alpha), and interleukin-1beta (IL-1beta) in DC cells: C2,3,6 chitosan sulfate-HACC (C2,3,6-HACC; 200 kDa), C3,6 chitosan sulfate-HACC (C3,6-HACC; 200 kDa) and C6 chitosan sulfate-HACC (C6-HACC; 50 kDa). c3,6 chitosan sulfate-hacc 215-241 interleukin 6 Homo sapiens 59-72 33197672-4 2021 RS2 might be able to reduce inflammatory mediators, therefore; our aim for this study was indicating RS2 effects on inflammatory mediators such as IL-6, TNF-a, and CRP among healthy and unhealthy subjects. n-hydroxy-2-[4-(4-phenoxy-benzenesulfonyl)-tetrahydro-pyran-4-yl]-acetamide 0-3 interleukin 6 Homo sapiens 147-151 33197672-4 2021 RS2 might be able to reduce inflammatory mediators, therefore; our aim for this study was indicating RS2 effects on inflammatory mediators such as IL-6, TNF-a, and CRP among healthy and unhealthy subjects. n-hydroxy-2-[4-(4-phenoxy-benzenesulfonyl)-tetrahydro-pyran-4-yl]-acetamide 101-104 interleukin 6 Homo sapiens 147-151 33259114-10 2021 In addition, gracillin inhibits IL6-induced nuclear translocation of P-STAT3. gracillin 13-22 interleukin 6 Homo sapiens 32-35 33225679-7 2020 Our data demonstrate that furosemide inhibits the secretion of proinflammatory TNF-alpha, IL-6, and nitric oxide; downregulates the mRNA level of Cd86 and the protein expression of COX-2, iNOS; promotes phagocytic activity; and enhances the expression of anti-inflammatory IL-1RA and arginase. Furosemide 26-36 interleukin 6 Homo sapiens 90-94 33095981-4 2020 Here, we report that ROCK inhibition by Y-27632 reduces levels of IL-1alpha, IL-1beta, IL-6 and IL-8 secreted by senescent normal and dysplastic oral keratinocytes without affecting the permanent cell growth arrest. Y 27632 40-47 interleukin 6 Homo sapiens 87-91 33199994-6 2020 In addition, DMF also decreased the expression of inflammatory factors [including IL-6, IL-8, matrix metalloproteinase (MMP)3 and MMP13] in NP cells. Dimethyl Fumarate 13-16 interleukin 6 Homo sapiens 82-86 33553467-11 2021 The median levels of IL-6 were significantly higher among CCP donors who were hospitalized versus nonhospitalized (P < .0014). ccp 58-61 interleukin 6 Homo sapiens 21-25 33170220-10 2021 Following exposure to deoxynivalenol, the secretion of interleukin (IL)-1beta, IL-6, IL-8, and/or tumor necrosis factor (TNF)-alpha in BEAS-2B cells, as well as EoL-1 cells, increased significantly. deoxynivalenol 22-36 interleukin 6 Homo sapiens 79-83 33225149-11 2020 THP-1 macrophages co-treated with WWL113 and PGD2-G prior to stimulation with lipopolysaccharide exhibited a more pronounced attenuation of pro-inflammatory cytokine levels (interleukin-6 and TNFalpha) than by PGD2-G treatment alone. 1(3)-glyceryl-PGD2 45-51 interleukin 6 Homo sapiens 174-187 32889778-4 2020 Icaritin is a small molecule that has displayed anticancer activities via IL-6/JAK/STAT3 pathways in tumour cells and immune cells including CD8+ T cells, MDSCs, neutrophils and macrophages. icaritin 0-8 interleukin 6 Homo sapiens 74-78 32952647-10 2020 By contrast, double azide caused a significant decrease in the levels of IFN-gamma and IL-6. Azides 20-25 interleukin 6 Homo sapiens 87-91 32952647-11 2020 The results of the present study indicated that mCRP, pCRP, oxLD and possibly azide, individually or in different combinations, had the tendency to upregulate the expression of IL-4 and to downregulate that of the pro-atherogenic cytokines, IFN-gamma and IL-6, suggesting that the intima microenvironment serves a crucial role in atherogenesis. Azides 78-83 interleukin 6 Homo sapiens 255-259 32852592-2 2020 In this study, we investigated the anti-STAT3 mechanism of the dietary polyphenol, biochanin A (BCA), in IL-6-treated macrophages. Polyphenols 71-81 interleukin 6 Homo sapiens 105-109 32649272-7 2020 The National Academy of Medicine"s Standards for Systematic Reviews were independently employed to identify clinical and prospective cohort studies assessing the relationship of magnesium with interleukin-6, a prominent drug target for treating COVID-19. Magnesium 178-187 interleukin 6 Homo sapiens 193-206 33254564-0 2020 Role of inositol to improve surfactant functions and reduce IL-6 levels: A potential adjuvant strategy for SARS-CoV-2 pneumonia? Inositol 8-16 interleukin 6 Homo sapiens 60-64 33254564-5 2020 In addition, myo-inositol has been found able to decrease the levels of IL-6 in several experimental settings, due to an effect on the inositol-requiring enzyme 1 (IRE1)-X-box-binding protein 1 (XBP1) and on the signal transducer and activator of transcription 3 (STAT3) pathways. Inositol 13-25 interleukin 6 Homo sapiens 72-76 33254564-6 2020 In this scenario, treatment with myo-inositol may be able to reduce IL-6 dependent inflammatory response and improve oxygenation in patients with severe ARDS by SARS-CoV-2. Inositol 33-45 interleukin 6 Homo sapiens 68-72 33204262-11 2020 Meanwhile, BR treatment reduced the plasma levels of TNF-alpha, IL-1beta, and IL-6, and increased the level of IL-10(p < 0.05). Bromine 11-13 interleukin 6 Homo sapiens 78-82 33060625-3 2020 We found that calcipotriol decreased CAF proliferation and migration and reduced the release of the pro-tumorigenic factors prostaglandin E2, IL-6, periostin, and leukemia inhibitory factor. calcipotriene 14-26 interleukin 6 Homo sapiens 142-146 31480216-5 2019 Docosahexaenoic acid upregulated filaggrin and loricrin expression at mRNA levels in addition to suppressing overexpression of tumor necrosis factor-alpha (TNF-alpha), interleukin-alpha (IL-1alpha), and interleukin-6 (IL-6) stimulated by polyinosinic-polycytidylic acid (poly I:C) plus lipopolysaccharide (LPS) (stimulation cocktail) in cultured NHEK cells. Docosahexaenoic Acids 0-20 interleukin 6 Homo sapiens 203-216 31480216-5 2019 Docosahexaenoic acid upregulated filaggrin and loricrin expression at mRNA levels in addition to suppressing overexpression of tumor necrosis factor-alpha (TNF-alpha), interleukin-alpha (IL-1alpha), and interleukin-6 (IL-6) stimulated by polyinosinic-polycytidylic acid (poly I:C) plus lipopolysaccharide (LPS) (stimulation cocktail) in cultured NHEK cells. Docosahexaenoic Acids 0-20 interleukin 6 Homo sapiens 218-222 31336542-6 2019 IL-6 levels correlated with pre-pregnancy body mass index (BMI), fasting blood sugar (FBS) and postprandial sugar (PPBS). Sugars 108-113 interleukin 6 Homo sapiens 0-4 31396334-11 2019 Inhibition of IL-6 by its antibody enhanced the killing effects of TMZ both in vivo and in vitro. Temozolomide 67-70 interleukin 6 Homo sapiens 14-18 31396334-12 2019 Overall, our results provided a rational to overcome the TMZ resistant in GBM treatment by targeting IL-6-STAT3-Snail pathway. Temozolomide 57-60 interleukin 6 Homo sapiens 101-105 32905367-2 2020 The present study aimed to explore the clinical efficacy of azithromycin combined with doxycycline in patients with NGU and its effect on serum levels of inflammatory cytokine interleukin-6 (IL-6). Doxycycline 87-98 interleukin 6 Homo sapiens 176-189 32905367-2 2020 The present study aimed to explore the clinical efficacy of azithromycin combined with doxycycline in patients with NGU and its effect on serum levels of inflammatory cytokine interleukin-6 (IL-6). Doxycycline 87-98 interleukin 6 Homo sapiens 191-195 31336542-6 2019 IL-6 levels correlated with pre-pregnancy body mass index (BMI), fasting blood sugar (FBS) and postprandial sugar (PPBS). Polybrominated Biphenyls 115-119 interleukin 6 Homo sapiens 0-4 30640654-9 2019 IL-6 values were significantly lower in the levobupivacaine group 72 hours after surgery (p=0.02). Levobupivacaine 44-59 interleukin 6 Homo sapiens 0-4 33015093-13 2020 Moreover, the stress marker 8-oxo-dG was independently associated with NAFLD after adjustment for mtDNAcn, IL-6, glucose tolerance status, and other conventional NAFLD risk factors (OR = 1.707, 95% CI =1.142-2.550, P = 0.009). 8-ohdg 28-36 interleukin 6 Homo sapiens 107-111 31273548-1 2019 We present an electrolyte-gated graphene field effect transistor (GFET) nanosensor using aptamer for rapid, highly sensitive and specific detection of a lung cancer biomarker interleukin-6 (IL-6) with enhanced stability. Graphite 32-40 interleukin 6 Homo sapiens 175-188 31273548-1 2019 We present an electrolyte-gated graphene field effect transistor (GFET) nanosensor using aptamer for rapid, highly sensitive and specific detection of a lung cancer biomarker interleukin-6 (IL-6) with enhanced stability. Graphite 32-40 interleukin 6 Homo sapiens 190-194 31273548-2 2019 The negatively charged aptamer folds into a compact secondary conformation upon binding with IL-6, thus altering the carrier concentration of graphene and yielding a detectable change in the drain-source current Ids. Graphite 142-150 interleukin 6 Homo sapiens 93-97 31273548-3 2019 Aptamer has smaller size than other receptors (e.g. antibodies), making it possible to bring the charged IL-6 more closely to the graphene surface upon affinity binding, thereby enhancing the sensitivity of the detection. Graphite 130-138 interleukin 6 Homo sapiens 105-109 32622469-5 2020 Inhaled furosemide, a small molecule capable of inhibiting IL-6 and TNFalpha, may be an agent capable of treating the Coronavirus Disease 2019 cytokine storm in both resource-rich and developing countries. Furosemide 8-18 interleukin 6 Homo sapiens 59-63 30627059-11 2018 In face of lipopolysaccharide (LPS) stimulation, Primovist , Omniscan , and Magnevist groups exhibited elevated nitrite/nitrate and suppressed IL-1beta secretion and IL-6 and IL-10 secretion. Gadolinium DTPA 76-85 interleukin 6 Homo sapiens 167-171 32554275-9 2020 Toxicological results revealed that indoor and personal exposure to OC as well as PAH compounds and their derivatives (e.g., Alkyl-PAHs, Oxy-PAHs) induced cell viability reduction and increase in levels of LDH, IL-6, and 8-isoprostane. oxy-pahs 137-145 interleukin 6 Homo sapiens 211-215 32891315-0 2020 miR-515-5p suppresses HCC migration and invasion via targeting IL6/JAK/STAT3 pathway. mir-515-5p 0-10 interleukin 6 Homo sapiens 63-66 32891315-7 2020 Furthermore, overexpression of miR-515-5p inhibited the activation of the JAK/STAT3 signaling pathway, which was rescued by overexpression of IL-6. mir-515-5p 31-41 interleukin 6 Homo sapiens 142-146 30867218-12 2019 CONCLUSIONS: Palbociclib resistance induces endocrine resistance, estrogen receptor downregulation, and alteration of IL6/STAT3 and DNA damage response pathways in cell lines and patient samples. palbociclib 13-24 interleukin 6 Homo sapiens 118-121 31307168-12 2019 Individuals with TC+CC genotype in pre-miR-499 T/C (rs3746444) had greater serum levels of IL-6 and hs-CRP than did patients with the TT genotype. Technetium 17-19 interleukin 6 Homo sapiens 91-95 30733764-8 2018 Kolaviron and selenium also reduced hydrogen peroxide-induced secretion of nitric oxide, TNF-alpha, IL-1 and IL-6 by transformed U937 cells. Selenium 14-22 interleukin 6 Homo sapiens 109-113 31212975-9 2019 U0126 and SB202190 could inhibit the expression of IL-6, IL-8 and MCP-1, but SP600125 could not. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 10-18 interleukin 6 Homo sapiens 51-55 32824426-9 2020 Co-inhibition of ERK and JNK signaling pathways by their specific inhibitors (PD9805 and SP600125, respectively) resulted in the suppression of mRNA and protein levels of IL-6, IL-1beta, and TNFalpha in FLS. pd9805 78-84 interleukin 6 Homo sapiens 171-175 30254184-0 2018 The STAT3 Inhibitor Galiellalactone Reduces IL6-Mediated AR Activity in Benign and Malignant Prostate Models. galiellalactone 20-35 interleukin 6 Homo sapiens 44-47 32742379-5 2020 Further investigation in RAW264.7 macrophages revealed that CAI decreased the production of nitric oxide via decreasing the LPS-stimulated expression of inducible nitric oxide synthase, and downregulated both mRNA and protein expression levels of the cytokines tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-6. carboxyamido-triazole 60-63 interleukin 6 Homo sapiens 318-322 32141013-11 2020 Gene expression level of TNF-alpha, IL-6 and IL-1beta was significantly reduced by amlodipine while an increase in expression level of IL-4 and IL-10 was evident in animals treated with piroxicam and amlodipine. Amlodipine 83-93 interleukin 6 Homo sapiens 36-40 32764938-8 2020 Results: beta-glucan nanoparticles can activate macrophages to produce immune enhancing cytokines (IL-1beta, IL-6, TNF-alpha, IFN-gamma). beta-Glucans 9-20 interleukin 6 Homo sapiens 109-113 30951948-6 2019 After 10 weeks of S-amlodipine treatment, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) levels were significantly lower and eNOS and NO production was significantly higher in the S-amlodipine group compared to the SHR group. Amlodipine 18-30 interleukin 6 Homo sapiens 86-99 30951948-6 2019 After 10 weeks of S-amlodipine treatment, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) levels were significantly lower and eNOS and NO production was significantly higher in the S-amlodipine group compared to the SHR group. Amlodipine 18-30 interleukin 6 Homo sapiens 101-105 30951948-6 2019 After 10 weeks of S-amlodipine treatment, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) levels were significantly lower and eNOS and NO production was significantly higher in the S-amlodipine group compared to the SHR group. Amlodipine 198-210 interleukin 6 Homo sapiens 86-99 31007743-7 2019 The results demonstrated that exogenous H2S reduced serum myocardial enzyme levels, decreased the levels of the inflammatory factors tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, and increased the level of anti-inflammatory IL-10 following CLP. Hydrogen Sulfide 40-43 interleukin 6 Homo sapiens 171-189 30254184-10 2018 Taken together, this finding demonstrates that targeting the IL6/STAT3 pathway with galiellalactone is a viable option to decrease AR activity in prostate tissue that may be applied in a personalized medicine approach. galiellalactone 84-99 interleukin 6 Homo sapiens 61-64 30900815-4 2019 The in vitro study indicates that supplementation of high-dose DHA+EPA induces the greatest decrease of IL-6 production by PBMCs relative to other groups (p = 0.046). Docosahexaenoic Acids 63-66 interleukin 6 Homo sapiens 104-108 30257125-1 2018 Exposures to occupationally relevant ultrafine, zinc- and copper-containing welding fumes cause inflammatory responses involving systemic IL-6, C-reactive protein (CRP) and serum amyloid A (SAA), all associated with elevated risk of cardiovascular events. ultrafine 37-46 interleukin 6 Homo sapiens 138-142 31008484-11 2019 PI3K inhibitor LY294002 and P38 inhibitor SB202190 blocked 17-phenyl-trinor-PGE2-induced IL-1beta and IL-6 output, respectively. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 42-50 interleukin 6 Homo sapiens 102-106 30822454-5 2019 Expression analysis showed a significant effect of tibolone on genes associated with inflammation such as IL6, IL1B and miR155-3p. tibolone 51-59 interleukin 6 Homo sapiens 106-109 32645052-0 2020 Mycophenolic acid and 6-mercaptopurine both inhibit B-cell proliferation in granulomatosis with polyangiitis patients, whereas only mycophenolic acid inhibits B-cell IL-6 production. Mycophenolic Acid 132-149 interleukin 6 Homo sapiens 166-170 32704455-10 2020 Upon treatment with furosemide, LPS-induced production of pro-inflammatory cytokines was reduced, indicating that furosemide suppresses the M1 polarization, including IL-6 and TNF-alpha release. Furosemide 20-30 interleukin 6 Homo sapiens 167-171 32704455-10 2020 Upon treatment with furosemide, LPS-induced production of pro-inflammatory cytokines was reduced, indicating that furosemide suppresses the M1 polarization, including IL-6 and TNF-alpha release. Furosemide 114-124 interleukin 6 Homo sapiens 167-171 32704455-12 2020 Accordingly, we conclude that furosemide is a reasonably potent inhibitor of IL-6 and TNF-alpha that is also safe, inexpensive and well-studied. Furosemide 30-40 interleukin 6 Homo sapiens 77-81 30191990-5 2019 LA, DHA, 12(S)-HETE, and RvD1 elicited mRNA expression of proinflammatory markers; tumor necrosis factor-alpha ( Tnf-alpha), interleukin 6 ( IL-6), chemokine (C-C motif) ligand 2 (Ccl2), and IL-1beta in wild type (WT) and in 12/15LOX -/- macrophages at early time point (4 hr). Docosahexaenoic Acids 4-7 interleukin 6 Homo sapiens 125-138 30487129-7 2018 In 2014, the anti-IL-6 therapy siltuximab became the first iMCD treatment approved by the US Food and Drug Administration, on the basis of a 34% durable response rate; consensus guidelines recommend it as front-line therapy. imcd 59-63 interleukin 6 Homo sapiens 18-22 30191990-5 2019 LA, DHA, 12(S)-HETE, and RvD1 elicited mRNA expression of proinflammatory markers; tumor necrosis factor-alpha ( Tnf-alpha), interleukin 6 ( IL-6), chemokine (C-C motif) ligand 2 (Ccl2), and IL-1beta in wild type (WT) and in 12/15LOX -/- macrophages at early time point (4 hr). Docosahexaenoic Acids 4-7 interleukin 6 Homo sapiens 141-145 30690246-7 2019 The increase of IL-6 showed a statistically significant correlation with myristic acid, to a lesser extent with cis-9-eicosenoic acid and to the least extent with docosahexaenoic acid, inversely with pentadecanoic, gamma-linolenic and stearic acids. Docosahexaenoic Acids 163-183 interleukin 6 Homo sapiens 16-20 30758933-5 2019 On this coculture model, 2D bP may increase anti-inflammatory cytokine generation (i.e., interleukin-10) and inhibit proinflammatory mediators synthesis (i.e., interleukin-6), thus suggesting the opportunity to prevent cancer-related inflammation. Benzo(a)pyrene 28-30 interleukin 6 Homo sapiens 160-173 32490857-6 2020 The polyphenols and their microbial metabolites alleviate IBD through reduction of oxidative stress, inhibition of inflammatory cytokines secretion (TNF-alpha, IL-6, IL-8, and IL-1beta), suppression of NF-kappaB, upregulation of Nrf2, gut barrier protection, and modulation of immune function. Polyphenols 4-15 interleukin 6 Homo sapiens 160-164 30429487-6 2018 In addition, a single intra-discal injection of NTG-101 into the injured IVD-NPs resulted in sustained expression of healthy extra-cellular matrix (ECM) proteins (aggrecan, collagen 2A1) and reduced expression of inflammation associated proteins and molecules (IL-1beta, IL-6, IL-8, MMP-13, Cox-2 and PGE2) as compared to vehicle controls. ntg-101 48-55 interleukin 6 Homo sapiens 271-275 32560222-12 2020 Notably, an increased level of the tumor suppressor, miR-142-3p, whose targets include LGR5, IL-6, and ABCG2, was detected in association with MSI-N1014 treatment. msi-n1014 143-152 interleukin 6 Homo sapiens 93-97 30508574-4 2019 N3 PUFAs (DHA 8.7 muM/EPA14.21 muM) or clozapine (3 muM) significantly reduced poly I:C-induced increase in iNOS, NFkB (p50/p65), IL-6 and nitrite when compared to non-treated cells. Clozapine 39-48 interleukin 6 Homo sapiens 130-134 30427403-6 2018 The presence of DPC in individuals with LR immunoregulated IL-6, IFN-gamma, and IL-4 concentrations. dpc 16-19 interleukin 6 Homo sapiens 59-63 30713340-7 2019 DA treatment delayed the inhibition of interleukin-6 secretion, which is mediated by both COX-dependent and independent pathways. amsonic acid 0-2 interleukin 6 Homo sapiens 39-52 32560222-14 2020 Tumor samples from the MSI-N1014 group showed markedly reduced expressions of LGR5, beta-catenin, IL-6, and mTOR, but increased expression of the tumor suppressor, miR-142-3p, according to qRT-PCR analysis. msi-n1014 23-32 interleukin 6 Homo sapiens 98-102 30427403-7 2018 The presence of DPC decreased serum levels of IL-6 and IL-4 in reactional individuals. dpc 16-19 interleukin 6 Homo sapiens 46-50 30292828-7 2018 AP also inhibited UVA-induced inflammatory mediators such as NF-kappaB, TNF-alpha and IL-6 expression in HaCaT cells. uva 18-21 interleukin 6 Homo sapiens 86-90 32229367-4 2020 Our results revealed that low doses of DON increased the expressions of TNF-alpha and IL-6 in piglets and PAMs, promoted the chemotaxis and phagocytosis of PAMs and transformed macrophages to M1 phenotype (P < 0.05). deoxynivalenol 39-42 interleukin 6 Homo sapiens 86-90 32049375-7 2020 The MCI/MI- or MI- induced secretion of IL-1beta, TNF and IL-6 by PBMC was analysed by flow cytometry. Inositol 8-10 interleukin 6 Homo sapiens 58-62 32049375-7 2020 The MCI/MI- or MI- induced secretion of IL-1beta, TNF and IL-6 by PBMC was analysed by flow cytometry. Inositol 15-17 interleukin 6 Homo sapiens 58-62 31508724-8 2019 An increase in the levels of IL-2, IL-4, IL-6, IL-10 and TNF-alpha was observed in the ATS and CS groups. Astatine 87-90 interleukin 6 Homo sapiens 41-45 29714141-13 2019 Consistently, other IL-6/GP130 inhibitors SC144 and evista showed similar inhibition of IL-6 stimulated cell viability, cell proliferation and glycolysis. SC 144 42-47 interleukin 6 Homo sapiens 20-24 29714141-13 2019 Consistently, other IL-6/GP130 inhibitors SC144 and evista showed similar inhibition of IL-6 stimulated cell viability, cell proliferation and glycolysis. SC 144 42-47 interleukin 6 Homo sapiens 88-92 29987550-8 2018 Two-month treatment with HCQ resulted in significant decrease in SLEDAI-2K (p < 0.001), anti-dsDNA (p < 0.001), IL-1beta (p = 0.003), IL-6 (p < 0.001) and TNF-alpha (p < 0.001) and a significant increase in CH50 levels (p = 0.012). Hydroxychloroquine 25-28 interleukin 6 Homo sapiens 140-144 30466028-6 2019 Moreover, linagliptin suppresses TNF-alpha-induced production of pro-inflammatory and pro-adhesive vascular cytokines including IL-6, IL-8, ICAM-1, and VCAM-1. Linagliptin 10-21 interleukin 6 Homo sapiens 128-132 30574167-9 2018 Results: FP and MP-AzeFlu (all dilutions) and AZE (1:102) significantly reduced IL-6 secretion and eosinophil survival compared with positive controls. azeflu 19-25 interleukin 6 Homo sapiens 80-84 32517881-10 2020 High-dose intravenous methylprednisolone treatment significantly reduced the levels of ET-1 and interleukin (IL)-6 in blood, but significantly increased the serum concentrations of IL-10 in NMOSD patients. Methylprednisolone 22-40 interleukin 6 Homo sapiens 96-114 32474413-7 2020 Thus, early IL-6 blockade may reduce the undesired sequelae of CRS upon bsAb therapy without affecting therapeutic activity, allowing in turn for safe application of effective doses. Antibodies, Bispecific 72-76 interleukin 6 Homo sapiens 12-16 30258361-5 2018 The CHCl3 fraction was found to inhibit CSC-induced IL-6 expression in human airway epithelial cells and to suppress the infiltration of inflammatory cells (neutrophils and macrophages) and secretion of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in the mouse model. Chloroform 4-9 interleukin 6 Homo sapiens 52-56 32316988-5 2020 RESULTS: Exposure to both Si10 and Min-U-Sil induced gene expression and release of CXCL8, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), interleukin-1alpha (IL-1alpha) and interleukin-1beta (IL-1beta) in a concentration-dependent manner. si10 26-30 interleukin 6 Homo sapiens 91-104 32316988-5 2020 RESULTS: Exposure to both Si10 and Min-U-Sil induced gene expression and release of CXCL8, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), interleukin-1alpha (IL-1alpha) and interleukin-1beta (IL-1beta) in a concentration-dependent manner. si10 26-30 interleukin 6 Homo sapiens 106-110 32271889-15 2020 Cis-UCA can prevent the secretion of IL-1beta and IL-18 and therapeutically reduces the levels of IL-6, IL-8, and LDH in UV-B-stressed HCE cells. cis-Urocanic acid 0-7 interleukin 6 Homo sapiens 98-102 30320369-7 2018 The results revealed that Evo dose-dependently reduced the protein and mRNA expression levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-1beta, and inhibited the levels of phosphorylated (p-) inhibitor of NF-kappaBalpha, p-extracellular signal-regulated kinase, p-c-Jun N-terminal kinase and p-p38, and decreased the nuclear translocation of NF-kappaB/p65 in BEAS-2B cells infected with MSSA. evodiamine 26-29 interleukin 6 Homo sapiens 132-150 30360960-6 2018 AlaGln supplementation significantly increased CA-125 appearance rate and ex vivo stimulated IL-6 release. alanylglutamine 0-6 interleukin 6 Homo sapiens 93-97 30390336-0 2018 Icaritin inhibits glioblastoma cell viability and glycolysis by blocking the IL-6/Stat3 pathway. icaritin 0-8 interleukin 6 Homo sapiens 77-81 30258361-5 2018 The CHCl3 fraction was found to inhibit CSC-induced IL-6 expression in human airway epithelial cells and to suppress the infiltration of inflammatory cells (neutrophils and macrophages) and secretion of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in the mouse model. Chloroform 4-9 interleukin 6 Homo sapiens 279-292 30390336-11 2018 Icaritin inhibited the IL-6/Stat3 pathway, which is evidenced by the decreased expressions of p-Stat3 and Bmi-1. icaritin 0-8 interleukin 6 Homo sapiens 23-27 30390336-12 2018 IL-6 treatment induced the phosphorylation of Stat3 and Bmi-1 expression, increased cell viability, as well as elevated glucose consumption, lactate production, and HK2 expression; however, the effects of IL-6 were attenuated by icaritin or S3I-201 treatment. icaritin 229-237 interleukin 6 Homo sapiens 0-4 31773440-6 2020 Results disclosed that ar-turmerone dose-dependently suppressed proliferation, facilitated apoptosis, and reduced TNF-alpha-mediated production of interleukin (IL)-1beta, IL-6, and IL-8 in HaCaT cells. ar-turmerone 23-35 interleukin 6 Homo sapiens 171-175 30258361-5 2018 The CHCl3 fraction was found to inhibit CSC-induced IL-6 expression in human airway epithelial cells and to suppress the infiltration of inflammatory cells (neutrophils and macrophages) and secretion of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in the mouse model. Chloroform 4-9 interleukin 6 Homo sapiens 294-298 30390336-12 2018 IL-6 treatment induced the phosphorylation of Stat3 and Bmi-1 expression, increased cell viability, as well as elevated glucose consumption, lactate production, and HK2 expression; however, the effects of IL-6 were attenuated by icaritin or S3I-201 treatment. icaritin 229-237 interleukin 6 Homo sapiens 205-209 30390336-13 2018 In conclusion, icaritin exerted inhibitory effects on cell viability and glycolysis in GBM cells, which was mediated by the IL-6/Stat3 pathway. icaritin 15-23 interleukin 6 Homo sapiens 124-128 30258361-6 2018 Similarly, each of the seven lignans isolated from the CHCl3 fraction also suppressed the infiltration of inflammatory cells (neutrophils and macrophages) and secretion of inflammatory mediators such as reactive oxygen species (ROS), TNF-alpha, and IL-6 in vivo. Chloroform 55-60 interleukin 6 Homo sapiens 249-253 30051214-9 2018 The serum IL-6 and CRP levels were inversely correlated with the plasma concentration ratios of N-desmethyltramadol to tramadol and of N,O-didesmethyltramadol to O-desmethyltramadol. O,N-didesmethyltramadol 135-158 interleukin 6 Homo sapiens 10-14 32257967-7 2020 Further, the miR-378d mimic suppressed, while its inhibitor enhanced the protein production of IL-1beta, TNF-alpha, IL-6, and Rab10 expression. mir-378d 13-21 interleukin 6 Homo sapiens 116-120 29803716-10 2018 The following compounds showed a significant small to large effect in reducing IL-6 levels: probiotics (-0.68 pg/ml), ARBs (-0.37 pg/ml) and omega-3 (-0.19 pg/ml). omega-3 141-148 interleukin 6 Homo sapiens 79-83 31327083-8 2020 DOXY group exhibited a significant increase in the levels of anti-inflammatory interleukin (IL)-10 and a reduction in IL-8, IFN-y, IL-6, and IL-17 (p < 0.05), significant reduction in periodontal pathogens (p < 0.05), and a lower mean percentage of HbA1C at 3 months (p < 0.05). Doxycycline 0-4 interleukin 6 Homo sapiens 131-135 30080291-0 2018 Esculentoside A suppresses breast cancer stem cell growth through stemness attenuation and apoptosis induction by blocking IL-6/STAT3 signaling pathway. esculentoside A 0-15 interleukin 6 Homo sapiens 123-127 29288248-9 2018 However, blood IL-6 levels were marginally decreased by 0.32 pg/ml (95% CI: -0.71, 0.07; P = 0.11) following CLA supplementation. Linoleic Acids, Conjugated 109-112 interleukin 6 Homo sapiens 15-19 30402044-2 2018 Neostigmine suppressed (p < 0.05) LPS-stimulated synthesis of cytokines such as interleukin- (IL-) 1beta, IL-6, and tumor necrosis factor (TNF) alpha in the POA, and this effect was similar to that induced by the treatment with systemic AChE inhibitor-donepezil (2.5 mg/animal). Neostigmine 0-11 interleukin 6 Homo sapiens 109-113 30119218-6 2018 The presence of loratadine in endothelial culture efficiently suppressed ox-LDL-induced attachment of monocytes to endothelial cells, production of ROS and vascular adhesion molecules, and induction cytokines including VCAM-1, E-selectin, TNF-alpha, IL-6 and IL-8. Loratadine 16-26 interleukin 6 Homo sapiens 250-254 32014904-8 2020 Iodixanol-induced inflammatory cytokines TNFa and IL-6 and inflammatory genes Nrf2 and ICAM-1 were reduced by ELA32 treatment (p<0.01). iodixanol 0-9 interleukin 6 Homo sapiens 50-54 31848666-3 2020 In the present study, we demonstrated for the first time that estimated human daily DON exposure (25 mug/kg bw) for 30 and 90 days caused low-grade inflammatory infiltration around hepatic centrilobular veins, elevated systemic IL-1beta, IL-6 and TNF-alpha and impaired liver function evidenced by increased serum ALT activity. deoxynivalenol 84-87 interleukin 6 Homo sapiens 238-242 29683274-5 2018 Using novel OMV-based drug screening systems, a total of 178 commercially available drugs are primarily screened, and a total of 18 repositioned drug candidates are found to effectively block IL-6 and TNF-alpha production from OMV-stimulated macrophages. 1-ethylcyclopentyl [(2R,6S,12Z,13aS,14aR,16aS)-2-[(7-methoxy-3-methylquinoxalin-2-yl)oxy]-14a-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl]carbamate 12-15 interleukin 6 Homo sapiens 192-196 31979221-7 2020 Conversely, treatment of carboplatin-resistant cells expressing high levels of endogenous IL-6 with the monoclonal anti-IL-6R antibody tocilizumab changed their status to "platinum-sensitive", exhibiting a decreased IC50 value for carboplatin, decreased growth, and significantly higher estrogen metabolism. Estrogens 287-295 interleukin 6 Homo sapiens 90-94 31805184-8 2020 Systemic administration of C-miR146a oligonucleotide alleviated human monocyte-dependent release of IL-1 and IL-6 in a xenotransplanted B-cell lymphoma model without affecting CD19-specific CAR T-cell antitumor activity. c-mir146a oligonucleotide 27-52 interleukin 6 Homo sapiens 109-113 30218674-6 2018 The levels of TNF-alpha and IL-6 were significantly decreased after treatment with Andro, both in vivo and in vitro, due to the inhibition of nuclear transcription factor-kappaB (NF-kappaB) signaling pathway activation. andrographolide 83-88 interleukin 6 Homo sapiens 28-32 30261896-10 2018 In the CSF, methylprednisolone attenuated the interleukin-6 release (p < 0.001), which could be explained by the fall in systemic interleukin-6, and the serum to CSF gradient of IL-6 seen both at baseline and after surgery. Methylprednisolone 12-30 interleukin 6 Homo sapiens 46-59 29683274-6 2018 After excluding the compounds which are previously known to intervene sepsis or which show cytotoxicity to macrophages, the compounds which show dose-dependency in inhibiting the release of IL-6 and TNF-alpha by the OMV-stimulated macrophages in vitro and which reduce OMV-induced SIRS in vivo are selected. 1-ethylcyclopentyl [(2R,6S,12Z,13aS,14aR,16aS)-2-[(7-methoxy-3-methylquinoxalin-2-yl)oxy]-14a-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl]carbamate 216-219 interleukin 6 Homo sapiens 190-194 30261896-10 2018 In the CSF, methylprednisolone attenuated the interleukin-6 release (p < 0.001), which could be explained by the fall in systemic interleukin-6, and the serum to CSF gradient of IL-6 seen both at baseline and after surgery. Methylprednisolone 12-30 interleukin 6 Homo sapiens 133-146 30261896-10 2018 In the CSF, methylprednisolone attenuated the interleukin-6 release (p < 0.001), which could be explained by the fall in systemic interleukin-6, and the serum to CSF gradient of IL-6 seen both at baseline and after surgery. Methylprednisolone 12-30 interleukin 6 Homo sapiens 181-185 32051736-6 2020 Importantly, we also demonstrate the ability of P2X7R antagonism using A804598 to suppress oxidative stress, expression of interleukin (IL)-1beta, IL-6, MMP-1, MMP-3, MMP-13 as well as activation of the Janus family of tyrosine kinase/signal transducer and activator of transcription (JAK1/STAT3) proinflammatory signaling pathway. 2-cyano-1-((1S)-1-phenylethyl)-3-quinolin-5-ylguanidine 71-78 interleukin 6 Homo sapiens 147-151 29683274-6 2018 After excluding the compounds which are previously known to intervene sepsis or which show cytotoxicity to macrophages, the compounds which show dose-dependency in inhibiting the release of IL-6 and TNF-alpha by the OMV-stimulated macrophages in vitro and which reduce OMV-induced SIRS in vivo are selected. 1-ethylcyclopentyl [(2R,6S,12Z,13aS,14aR,16aS)-2-[(7-methoxy-3-methylquinoxalin-2-yl)oxy]-14a-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl]carbamate 269-272 interleukin 6 Homo sapiens 190-194 30333271-7 2018 Alphacalcidol did not decrease IL-6 (p=0.4) and g- IFN (p=0.001), but it increased IL-10 (p=0,005) and decreased IL6/IL10 ratio (p=0.008). alfacalcidol 0-13 interleukin 6 Homo sapiens 113-116 31585097-4 2020 To develop the new IL-6 quantitative detecting kit, a double-antibody sandwich immunofluorescent assay was employed based on europium nanoparticles (Eu-np) combined with lateral flow immunoassay (LFIA). Europium 125-133 interleukin 6 Homo sapiens 19-23 31585097-4 2020 To develop the new IL-6 quantitative detecting kit, a double-antibody sandwich immunofluorescent assay was employed based on europium nanoparticles (Eu-np) combined with lateral flow immunoassay (LFIA). Europium 149-151 interleukin 6 Homo sapiens 19-23 30288187-0 2018 Losartan, but not Enalapril and Valsartan, Inhibits the Expression of IFN-gamma, IL-6, IL-17F and IL-22 in PBMCs from Rheumatoid Arthritis Patients. Losartan 0-8 interleukin 6 Homo sapiens 81-85 31585097-12 2020 The results indicated that the newly-developed strip based on Eu-np combined with LFIA was a facile, fast, highly sensitive, low-cost, reliable biosensor and suitable for rapid and point-of-care test (POCT) for IL-6 in serum. Europium 62-64 interleukin 6 Homo sapiens 211-215 30288187-8 2018 Results: Losartan was able to reduce levels of IFN-gamma (p = 0.0181), IL-6 (p = 0.0056), IL-17F (0.0046) and IL-22 (p = 0.0234) in RA patients. Losartan 9-17 interleukin 6 Homo sapiens 71-75 29229421-2 2018 BA-25 (3-alpha-o-acetoxy-4beta-amino-11-oxo-24-norurs-12-ene) an amino analogue of beta-boswellic acid exhibited inhibition of TNF-alpha and IL-6 in THP-1 cells as demonstrated previously, however, the effect on principal inflammatory mediators such as cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) and the pathways that mediate this function remains unknown. NIOSH/QD9140000 0-5 interleukin 6 Homo sapiens 141-145 30016752-2 2018 The aim of the study was to evaluate the influence of PDT with delta-aminolevulinic acid (ALA-PDT) used in sub-lethal dose on the interleukins secretion (IL-6, IL-8 and IL-10) by the residual colon cancer cells (CCC) under hypoxia-like conditions (addition of cobalt chloride- CoCl2). Aminolevulinic Acid 63-88 interleukin 6 Homo sapiens 154-158 31509822-9 2020 IL-8 and IL-6 clearance were higher with Hemofeel (continuous venovenous hemodiafiltration) than with EMiC2 (continuous venovenous hemodialysis) because the polymethyl methacrylate (PMMA)-based membrane Hemofeel is able to remove these 2 cytokines by adsorption. hemofeel 41-49 interleukin 6 Homo sapiens 9-13 29656207-5 2018 The results demonstrated that the increased expression levels of interleukin-1beta (IL-1beta), interleukin-6(IL-6), tumor necrosis factor-alpha (TNF-alpha) were significantly inhibited by DMY. dihydromyricetin 188-191 interleukin 6 Homo sapiens 95-108 30122920-6 2018 The NIPAM-hemin copolymer induced the production of interferon (IFN)-gamma and interleukin (IL)-6 from peripheral blood mononuclear cells, although hemin and the NIPAM monomer individually did not induce the production of any cytokines. nipam-hemin copolymer 4-25 interleukin 6 Homo sapiens 79-97 31753587-0 2020 Estrogen facilitates gastric cancer cell proliferation and invasion through promoting the secretion of interleukin-6 by cancer-associated fibroblasts. Estrogens 0-8 interleukin 6 Homo sapiens 103-116 29656207-5 2018 The results demonstrated that the increased expression levels of interleukin-1beta (IL-1beta), interleukin-6(IL-6), tumor necrosis factor-alpha (TNF-alpha) were significantly inhibited by DMY. dihydromyricetin 188-191 interleukin 6 Homo sapiens 109-113 31753587-7 2020 ELISA results suggested that CAFs produced interleukin-6 (IL-6) after estrogen treatment in a dose-dependent manner. Estrogens 70-78 interleukin 6 Homo sapiens 43-56 29510260-2 2018 The aim of our study was to investigate how photodynamic therapy with 5-aminolevulinic acid (ALA-PDT) in sublethal doses influences the secretion of interleukins 6, 8 and 10 from colon cancer cells in vitro. 5-amino levulinic acid 70-91 interleukin 6 Homo sapiens 149-173 31753587-7 2020 ELISA results suggested that CAFs produced interleukin-6 (IL-6) after estrogen treatment in a dose-dependent manner. Estrogens 70-78 interleukin 6 Homo sapiens 58-62 31753587-15 2020 Conclusively speaking, estrogen can activate CAFs to produce IL-6, ending up with promotion of GC cell proliferation and invasion. Estrogens 23-31 interleukin 6 Homo sapiens 61-65 30208836-5 2018 SO, ED, and GL stimulated production of pro-inflammatory IFN-gamma, IL-1beta, IL-2, IL-6, IL-8, TNF-alpha and anti-inflammatory IL-10. glycylleucine 12-14 interleukin 6 Homo sapiens 84-88 30123049-6 2018 The secretion of cytokines (IL-6, IL-2 and IFN-gamma) was suppressed in response to ibrutinib. ibrutinib 84-93 interleukin 6 Homo sapiens 28-32 29772762-9 2018 In humans, chloroquine treatment did not affect viremia or clinical parameters during the acute stage of the disease (D1 to D14), but affected the levels of C-reactive Protein (CRP), IFNalpha, IL-6, and MCP1 over time (D1 to D16). Chloroquine 11-22 interleukin 6 Homo sapiens 193-197 29499374-6 2018 BO downregulated the expression of MMP-1, MMP-3, and IL-6, and enhanced TGF-beta1 by modulating activator protein (AP-1) and nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) signaling in UVB-irradiated NHDFs. boron oxide 0-2 interleukin 6 Homo sapiens 53-57 29684500-7 2018 Among the mixed-type cases, the serum IL-6 levels in iMCD with TAFRO were significantly higher than those in iMCD without TAFRO. tafro 63-68 interleukin 6 Homo sapiens 38-42 32345772-6 2020 We found that RSV infection caused a marked increase in interleukin (IL)-6, IL-8, IL-1beta and tumor necrosis factor (TNF)- alpha production and release, which was concentration-dependently attenuated by EPB treatment. ephedrannin B 204-207 interleukin 6 Homo sapiens 56-74 31820601-1 2019 OBJECTIVE: To explore the clinical efficacy of acupuncture combined with Jingtong granule for nerve-root type cervical spondylosis and its effects on serum interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and hemorheological indexes. SELAPINA 82-89 interleukin 6 Homo sapiens 171-175 31820601-12 2019 CONCLUSION: Acupuncture combined with Jingtong granule have significant clinical efficacy for nerve-root type cervical spondylosis, which could reduce the serum levels of IL-6, TNF-alpha and IL-1beta and improve hemorheology. SELAPINA 47-54 interleukin 6 Homo sapiens 171-175 31817563-0 2019 Lemon Peel Polyphenol Extract Reduces Interleukin-6-Induced Cell Migration, Invasiveness, and Matrix Metalloproteinase-9/2 Expression in Human Gastric Adenocarcinoma MKN-28 and AGS Cell Lines. Polyphenols 11-21 interleukin 6 Homo sapiens 38-51 29684500-7 2018 Among the mixed-type cases, the serum IL-6 levels in iMCD with TAFRO were significantly higher than those in iMCD without TAFRO. tafro 122-127 interleukin 6 Homo sapiens 38-42 29728589-8 2018 Furthermore, interference of YAP nuclear translocation using the statin cerivastatin reverses the upregulation of Interleukin 6 (IL-6) and the pro-invasive effect of RA on MDA-MB-231 breast cancer cells and also decreases invasion and viability of MDA-MB-468 breast cancer cells. cerivastatin 72-84 interleukin 6 Homo sapiens 114-127 29663503-10 2018 Apart from these, miR-135a can also modulate inflammation molecules including IL-6, IL-1beta, and TNF-alpha. mir-135a 18-26 interleukin 6 Homo sapiens 78-82 31624951-0 2019 One week of magnesium supplementation lowers IL-6, muscle soreness and increases post-exercise blood glucose in response to downhill running. Magnesium 12-21 interleukin 6 Homo sapiens 45-49 31624951-12 2019 CONCLUSION: Magnesium supplementation reduced the IL-6 response, enhanced recovery of blood glucose, and muscle soreness after strenuous exercise, but did not improve performance or functional measures of recovery. Magnesium 12-21 interleukin 6 Homo sapiens 50-54 29728589-8 2018 Furthermore, interference of YAP nuclear translocation using the statin cerivastatin reverses the upregulation of Interleukin 6 (IL-6) and the pro-invasive effect of RA on MDA-MB-231 breast cancer cells and also decreases invasion and viability of MDA-MB-468 breast cancer cells. cerivastatin 72-84 interleukin 6 Homo sapiens 129-133 31123968-6 2019 Accordingly, LPS-induced increases in IL-1beta and IL-6 mRNA and TNF-alpha release were significantly and synergistically diminished by cilostazol and celecoxib cotreatment. Celecoxib 151-160 interleukin 6 Homo sapiens 51-55 29656890-2 2018 Amongst the evaluated compounds (6-9), bicyclic isoxazolidine (9a) was found to exhibit significant inhibitory potential against LPS induced human IL-6 and TNF-alpha in THP-1 cells. bicyclic isoxazolidine 39-61 interleukin 6 Homo sapiens 147-151 29525220-0 2018 Two new lathyrane-type diterpenoid glycosides with IL-6 production inhibitory activity from the roots of Euphorbia kansui. diterpenoid glycosides 23-45 interleukin 6 Homo sapiens 51-55 29875313-6 2018 Reduced monocyte NOTCH2 expression in nADA+ MS patients was associated with NOTCH2 activation measured by increased expression of Notch-responsive genes, polarization of monocytes toward a nonclassical phenotype, and increased proinflammatory IL-6 production. arachidonyl dopamine 38-42 interleukin 6 Homo sapiens 243-247 31123968-8 2019 Summarizing, cotreatment with cilostazol and celecoxib exhibited a synergistic increase in IL-10 production and SOCS3 expressions, thereby resulted in synergistic decreases in IL-1beta mRNA, IL-6 mRNA expression and TNF-alpha synthesis in association with synergistic decreases in COX-2 and PGE2 protein expression in the RA synovial fibroblasts. Celecoxib 45-54 interleukin 6 Homo sapiens 191-195 31739564-8 2019 At higher DON dosage, interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha mRNA levels were elevated in the intestinal tissues. deoxynivalenol 10-13 interleukin 6 Homo sapiens 46-50 29091301-6 2018 The frequencies of 634C/G genotype of IL-6 promoter were CC 38.29%, CG 46.81%, and GG 14.90%, while CC 59.51%, CG 35.11%, GG 6.38% in the control group (P < 0.01). cysteinylglycine 68-70 interleukin 6 Homo sapiens 38-42 31542660-0 2019 The organochlorine pesticides pentachlorophenol and dichlorodiphenyltrichloroethane increase secretion and production of interleukin 6 by human immune cells. Pentachlorophenol 30-47 interleukin 6 Homo sapiens 121-134 28835131-7 2018 DHA slightly countered the actions of IL-1beta on CCL2, IL6 and ADIPOQ expression, though not on secretion of these adipokines. Docosahexaenoic Acids 0-3 interleukin 6 Homo sapiens 56-59 29715306-11 2018 (PTX+DEX) synergistically decreased LPS- and LPS/ATP-induced TNF, IL-1beta, and IL-6, and R848-induced IL-1beta and interferon-alpha, while (PTX+AZI) synergistically decreased induction of TNF, IL-1beta, and IL-6. Pentoxifylline 1-4 interleukin 6 Homo sapiens 80-84 29715306-11 2018 (PTX+DEX) synergistically decreased LPS- and LPS/ATP-induced TNF, IL-1beta, and IL-6, and R848-induced IL-1beta and interferon-alpha, while (PTX+AZI) synergistically decreased induction of TNF, IL-1beta, and IL-6. Pentoxifylline 1-4 interleukin 6 Homo sapiens 208-212 29618430-7 2018 The ethyl acetate fraction significantly altered LDH levels and reduced IL-6 transcript expression on MCF7 cell line but not in HepG2 cell line which could be specific anti-inflammatory drug in breast cancer cell line. ethyl acetate 4-17 interleukin 6 Homo sapiens 72-76 29721322-5 2018 The interleukin (IL)-6 concentration was higher in the rhGH then in the TV-1106-treated plasma (P < .05). tv-1106 72-79 interleukin 6 Homo sapiens 4-22 31581708-9 2019 MK2206, an Akt inhibitor, impeded the modulation of MIEN1 on NDRG1 and IL-6 expressions. MK 2206 0-6 interleukin 6 Homo sapiens 71-75 31545261-8 2019 The mechanistic studies based on RNA-sequencing analysis revealed that limonin inhibited the gene transcription driven by Stat3 (signal transducer and activator of transcription 3) and an activator of Stat3 (Colivelin or IL-6) rescued the inhibitory effects of limonin. limonin 71-78 interleukin 6 Homo sapiens 221-225 29381560-0 2018 Omega-3 decreases IL-6 levels in HIV and human herpesvirus-8 coinfected patients in Uganda. omega-3 0-7 interleukin 6 Homo sapiens 18-22 30947576-0 2019 ERK-dependent IL-6 positive feedback loop mediates resistance against a combined treatment using danusertib and BKM120 in Burkitt lymphoma cell lines. danusertib 97-107 interleukin 6 Homo sapiens 14-18 29083034-2 2018 Lewis acids include those that can form chalcogen (HSF and HSBr), pnicogen (H2 PF and H2 PBr), and tetrel (H3 SiF and H3 SiBr) bonds, as well as H-bonds and halogen bonds. Lewis Acids 0-11 interleukin 6 Homo sapiens 51-54 29381560-9 2018 Inflammatory cytokine IL-6 concentrations decreased in omega-3 participants (-0.78 pg/ml) but increased in placebo participants (+3.2 pg/ml; P = 0.04). omega-3 55-62 interleukin 6 Homo sapiens 22-26 29381560-10 2018 We observed a trend toward decreased IL-6 after omega-3 supplementation specific to Kaposi sarcoma patients (P = 0.08). omega-3 48-55 interleukin 6 Homo sapiens 37-41 29223372-5 2018 The areas under the curve of the receiver operating characteristic (ROC) curves for discriminating between IPS and unaffected controls at day 7 post-HCT were .8 for ST2, .75 for IL-6, and .68 for TNFR1. IPS 107-110 interleukin 6 Homo sapiens 178-182 31584250-7 2019 In IL-1beta-stimulated cells, AOH (20-40 microm) augments TNF-alpha transcripts while repressing IL-8, IL-6, and IL-1beta transcription as well as IL-8 secretion. alternariol 30-33 interleukin 6 Homo sapiens 103-107 31162616-0 2019 Alleviation of infectious-bursal-disease-virus-induced bursal injury by betaine is associated with DNA methylation in IL-6 and interferon regulatory factor 7 promoter. Betaine 72-79 interleukin 6 Homo sapiens 118-122 29127842-8 2018 Dynamic compliance was significantly improved in the budesonide group on days 3 (p=0.018) and 5 (p=0.011) The levels of CXCL-8 and IL-6 diminished on days 3-5 after start of budesonide (p<0.05). Budesonide 53-63 interleukin 6 Homo sapiens 131-135 29127842-9 2018 CONCLUSION: In COPD patients on MV, nebulized budesonide was associated with reduced BAL CXCL8 and IL-6 levels and neutrophil numbers as well as an improvement in ventilatory mechanics and facilitated weaning. Budesonide 46-56 interleukin 6 Homo sapiens 99-103 31541125-8 2019 Furthermore, the production of IL6 induced by H2O2 was suppressed by the THGP treatment. Propionates 73-77 interleukin 6 Homo sapiens 31-34 29381560-12 2018 CONCLUSION: Omega-3 supplementation decreased IL-6 concentrations among HIV and HHV-8 coinfected Ugandans, which may have clinical benefit for Kaposi sarcoma patients. omega-3 12-19 interleukin 6 Homo sapiens 46-50 31299628-0 2019 A SERS-based lateral flow assay biosensor for quantitative and ultrasensitive detection of interleukin-6 in unprocessed whole blood. sers 2-6 interleukin 6 Homo sapiens 91-104 29587260-10 2018 In a human monocyte THP-1 model, verbascoside could suppress DNCB-induced upregulation of CD86 and CD54 at the cell surface, the secretion of the proinflammatory cytokines TNF-alpha and IL-6, and the activation of NFkappaB signaling in a dose-dependent manner. Dinitrochlorobenzene 61-65 interleukin 6 Homo sapiens 186-190 31299628-2 2019 A surface-enhanced Raman scattering (SERS)-based lateral flow assay (LFA) is developed for the quantitative analysis of IL-6. sers 37-41 interleukin 6 Homo sapiens 120-124 31299628-5 2019 The IL-6 protein can be detected by this method with very low detection limits by monitoring the intensity of the characteristic Raman peak of the IL-6-conjugated SERS tags at 1332 cm-1. sers 163-167 interleukin 6 Homo sapiens 4-8 31299628-5 2019 The IL-6 protein can be detected by this method with very low detection limits by monitoring the intensity of the characteristic Raman peak of the IL-6-conjugated SERS tags at 1332 cm-1. sers 163-167 interleukin 6 Homo sapiens 147-151 29495462-10 2018 For development of a new glaucoma drainage device, the silicones Silbione LSR 4330 and Silbione LSR 4350, in this study, with low cell counts for hTF and low proliferation indices for hSF, and silicone Silastic MDX4-4210, with low cell counts for hSF and low proliferation indices for hTF, have shown the best results in vitro. Silicones 55-63 interleukin 6 Homo sapiens 184-187 28857458-5 2017 Activated B cells cultivated on polystyrene (PS) showed an altered cytokine response indicated by increased IL-10 and decreased IL-6 secretion. Polystyrenes 32-43 interleukin 6 Homo sapiens 128-132 29511440-8 2018 Enzyme-linked immunosorbent assay (ELISA), flow cytometry and western blotting analyses showed that andrographolide could decreased the levels of proinflammatory factors TNF-alpha, IL-1beta, IL-6 and IL-17A in the serum and in the colon tissues, reduced the percentages of Th17 cells in CD4+ cells, and suppressed the levels of IL-23, IL-17A, ROR-gammat (key transcription factor of Th17 cells) and p-STAT3 in the colon tissues. andrographolide 100-115 interleukin 6 Homo sapiens 191-195 28840599-9 2018 The data indicate that BT-induced alterations of IL-6 secretion from immune cells may be a significant consequence of BT exposures that may potentially affect immune competence. benzothiazole 23-25 interleukin 6 Homo sapiens 49-53 28840599-9 2018 The data indicate that BT-induced alterations of IL-6 secretion from immune cells may be a significant consequence of BT exposures that may potentially affect immune competence. benzothiazole 118-120 interleukin 6 Homo sapiens 49-53 31048000-14 2019 The COX-2 specific celecoxib was identified as the most potent drug to reduce IL-6, IL-8 and TNF-alpha formation after SM exposures in vitro. Celecoxib 19-28 interleukin 6 Homo sapiens 78-82 31572383-13 2019 Dexamethasone and budesonide induced sftpd transcription and translation in human type II alveolar epithelial cells in a glucocorticoid receptor and STAT3 (an IL-6 responsive transcription factor) dependent manner. Budesonide 18-28 interleukin 6 Homo sapiens 159-163 28857458-5 2017 Activated B cells cultivated on polystyrene (PS) showed an altered cytokine response indicated by increased IL-10 and decreased IL-6 secretion. Polystyrenes 45-47 interleukin 6 Homo sapiens 128-132 31397158-5 2019 Interleukin (IL)-6 was associated with Oxy-PAHs of 1,8-naphthalic anhydride, xanthone, and benzo[h]quinolone, especially, whereas IL-1beta and tumor necrosis factor (TNF)-alpha were associated with most species. oxy-pahs 39-47 interleukin 6 Homo sapiens 0-18 29946640-5 2018 RESULTS: The concentration of IL-6 and TNF-alpha in serum and GCF of patients with GD+CP group was significantly higher than that in CP group and GD group (P<0.05). Gadolinium 83-85 interleukin 6 Homo sapiens 30-34 29123118-2 2017 Compared with polyester flat substrates having uniformly distributed homogenous pores (2D), three-dimensional polystyrene substrates with randomly oriented and interconnected pores of heterogeneous size (3D) stimulated the stromal secretion of IGF-1 while lessened the production of VEGFR-1, MCP-1 and IL-6. Polystyrenes 110-121 interleukin 6 Homo sapiens 302-306 29946640-5 2018 RESULTS: The concentration of IL-6 and TNF-alpha in serum and GCF of patients with GD+CP group was significantly higher than that in CP group and GD group (P<0.05). Gadolinium 146-148 interleukin 6 Homo sapiens 30-34 29946640-6 2018 The level of IL-6 and TNF-alpha in serum and GCF of patients in GD+CP group and GD group was positively correlated with FT3 and FT4 (P<0.05), and the correlation between GD+CP group was significantly higher than that in GD group. Gadolinium 64-66 interleukin 6 Homo sapiens 13-17 29946640-7 2018 CONCLUSIONS: The level of IL-6 and TNF-alpha in GD+CP group were significantly higher than those in CP group and GD group, indicating that there is an interaction between periodontitis and Graves" disease in immune mechanism. Gadolinium 48-50 interleukin 6 Homo sapiens 26-30 31397158-5 2019 Interleukin (IL)-6 was associated with Oxy-PAHs of 1,8-naphthalic anhydride, xanthone, and benzo[h]quinolone, especially, whereas IL-1beta and tumor necrosis factor (TNF)-alpha were associated with most species. 1,8-naphthalenedicarboxylic acid anhydride 51-75 interleukin 6 Homo sapiens 0-18 31282647-12 2019 Taken together, this series of studies demonstrate that METH-induced neuroinflammation is, at least in part, mediated by TLR4-IL6 signaling within the VTA, which has the downstream effect of elevating dopamine in the NAc shell. nac 217-220 interleukin 6 Homo sapiens 126-129 28892713-7 2017 SA also impairs CAC function and increases pro-inflammatory molecule (IL-1beta, IL-6, IL-8, MCP-1 and TNFalpha) gene expression and secretion in CACs starting from 3 h of incubation. stearic acid 0-2 interleukin 6 Homo sapiens 80-84 31069881-5 2019 Most importantly, 3o also inhibited interleukin-6-induced STAT3 activation and nuclear localization. 3o 18-20 interleukin 6 Homo sapiens 36-49 31028503-7 2019 SBP, HR and serum AQP-4, IL-6, NE, NSE levels, but not CSF AQP-4 levels, were significantly lower in MgSO4 group than in the routine treatment group. Magnesium Sulfate 101-106 interleukin 6 Homo sapiens 25-29 28966223-10 2018 We observed a positive correlation between changes in baPWV and circulating interleukin-6 (IL-6) levels. bapwv 54-59 interleukin 6 Homo sapiens 76-89 28966223-10 2018 We observed a positive correlation between changes in baPWV and circulating interleukin-6 (IL-6) levels. bapwv 54-59 interleukin 6 Homo sapiens 91-95 28966223-11 2018 Furthermore, multiple liner regression analysis revealed that change in baPWV was significantly associated with that in IL-6 levels after consideration of changes in systolic blood pressure and body mass index. bapwv 72-77 interleukin 6 Homo sapiens 120-124 28966223-12 2018 These results suggest that for overweight and obese men, a 12-week period of lifestyle modifications-induced a decrease in circulating cytokine levels (especially IL-6 levels), leads to decreased baPWV. bapwv 196-201 interleukin 6 Homo sapiens 163-167 29320557-10 2018 Two well-known ligands for AHR (TCDD and BaP) induced mRNA expression of IL1B and IL6 in an ERalpha-negative breast tumor cell line. Benzo(a)pyrene 41-44 interleukin 6 Homo sapiens 82-85 31316498-10 2019 Importantly, pre-treatment of cells with the iron-chelating agent deferoxamine completely abolished the hemin-dependent translocation of 5-LOX to the nuclear fraction, and significantly reverted its effect on interleukin-6 overexpression. Deferoxamine 66-78 interleukin 6 Homo sapiens 209-222 28954414-0 2017 Alpha-Lipoic Acid Downregulates IL-1beta and IL-6 by DNA Hypermethylation in SK-N-BE Neuroblastoma Cells. Thioctic Acid 0-17 interleukin 6 Homo sapiens 45-49 31252632-6 2019 At baseline, urinary ADMA, DMA, and SDMA excretion correlated positively with circulating TNF-alpha and IL-6. N,N-dimethylarginine 21-25 interleukin 6 Homo sapiens 104-108 30796902-12 2019 Molecular docking results indicates interaction of cinnamaldehyde and eugenol with key residues of TNF-alpha and IL-6. cinnamaldehyde 51-65 interleukin 6 Homo sapiens 113-117 30029729-8 2018 In summary, evidence from us and others indicates that DHEA may be useful for treating bone diseases through its inhibition of skeletal catabolic IL-6 and stimulation of anabolic IGF-I-mediated mechanisms. Dehydroepiandrosterone 55-59 interleukin 6 Homo sapiens 146-150 28954414-4 2017 These results prompted us to ask whether ALA-induced repression of IL-1b and IL-6 was dependent on DNA methylation. Thioctic Acid 41-44 interleukin 6 Homo sapiens 77-81 31453235-9 2017 Moreover, screening an IL-6-HaloTag -odorant receptor library with allyl phenyl acetate, revealed both known receptors as best responders for this compound. Allyl phenylacetate 67-87 interleukin 6 Homo sapiens 23-27 30902820-6 2019 BI 655064 was associated with greater changes in CD40-CD40L pathway-related markers, including reductions in inflammatory and bone resorption markers (interleukin-6, matrix metalloproteinase-3, receptor activator of nuclear factor-kappaB ligand), concentration of autoantibodies (immunoglobulin [Ig]G rheumatoid factor [RF], IgM RF, IgA RF) and CD95+ activated B-cell subsets. BI 655064 0-9 interleukin 6 Homo sapiens 151-164 28954414-8 2017 These results reinforce previous findings indicating that IL-1b and IL-6 undergo DNA methylation-dependent modulation in neural models and pave the road to study the epigenetic mechanisms triggered by ALA. Thioctic Acid 201-204 interleukin 6 Homo sapiens 68-72 28919708-11 2017 AOS treatment reduced the levels of miR-29b, TLR4, mitogen-activated protein kinase (MAPK), nuclear factor kappa B (NF-kappa B), interleukin 1 (IL-1) beta, and interleukin 6 (IL-6). D-(+)-ALLOSE 0-3 interleukin 6 Homo sapiens 160-173 30324573-5 2019 PGE2 increased at 1 and 2 h in both cell types, and IL6 increased only at 2 and 4 h in HPDFs. hpdfs 87-92 interleukin 6 Homo sapiens 52-55 30324573-8 2019 CONCLUSIONS: CF application on co-cultures of HPDFs and HABOs causes significant changes of TNFA, PTGS2, and IL6 gene expressions and PGE2 and IL6 production in comparison to mono-culture indicating intercellular communication. hpdfs 46-51 interleukin 6 Homo sapiens 109-112 30324573-8 2019 CONCLUSIONS: CF application on co-cultures of HPDFs and HABOs causes significant changes of TNFA, PTGS2, and IL6 gene expressions and PGE2 and IL6 production in comparison to mono-culture indicating intercellular communication. hpdfs 46-51 interleukin 6 Homo sapiens 143-146 28167299-9 2017 Calcipotriol and dexamethasone additively reduced the secretions of IL-6, IFN-gamma, basic FGF and VEGF in TNF-alpha stimulated SSC. calcipotriene 0-12 interleukin 6 Homo sapiens 68-72 28167299-10 2017 The level of IL-6 was still diminished at 10 days after exposure, emphasizing the long-term impact of calcipotriol on SSC. calcipotriene 102-114 interleukin 6 Homo sapiens 13-17 28887458-7 2017 Inhibition of 15-PGDH using either indomethacin or SW033291 significantly reduced the further conversion of 15-epi-LXA4 and MaR1 and regulated expression of IL-6, PDPN and STAT-1. SW033291 51-59 interleukin 6 Homo sapiens 157-161 28919708-11 2017 AOS treatment reduced the levels of miR-29b, TLR4, mitogen-activated protein kinase (MAPK), nuclear factor kappa B (NF-kappa B), interleukin 1 (IL-1) beta, and interleukin 6 (IL-6). D-(+)-ALLOSE 0-3 interleukin 6 Homo sapiens 175-179 28677720-8 2017 Pre-incubation of the EPCs with BAY11 for 1 h followed by treatment with visfatin (150 ng/ml) for 48 h also abolished visfatin-induced apoptosis; it also abolished the promoting effects of visfatin on the expression of caspase-3, Bax, ICAM-1 and IL-6, and its suppressive effects on the protein expression of Bcl-2. bay11 32-37 interleukin 6 Homo sapiens 246-250 28398068-4 2017 Supplementation of HIV-positive subjects with L-GSH for 3 months resulted in a notable increase in the levels of IL-12, IL-2, and IFN-gamma, with a concomitant decrease in the levels of IL-6, IL-10, and free radicals, and stabilization in the levels of TGF-beta, IL-1, and IL-17, compared to their placebo counterparts. l-gsh 46-51 interleukin 6 Homo sapiens 186-190 31159449-5 2019 Our previous studies demonstrated that increased interleukin (IL)-6, epidermal growth factor family ligands, and erbB2 receptor, some of which amplify inflammation and, consequently, induce CID, were induced by IH and were involved in the proliferation of VSMCs. vsmcs 256-261 interleukin 6 Homo sapiens 49-67 28643827-7 2017 We also studied the effect of sulfated alginate on the ability of IL-1beta to stimulate inflammatory genes in human chondrocytes and found decreased expression of the pro-inflammatory markers IL-6 and CXCL8, which inversely correlated with the sulfation degree. Alginates 39-47 interleukin 6 Homo sapiens 192-196 29474306-7 2019 Differences serum HbA1c, plasma total antioxidant capacity values, erythrocyte DHA content, and serum IL-6 levels were all significant in favor of the DHA-supplementation group. Docosahexaenoic Acids 151-154 interleukin 6 Homo sapiens 102-106 28904431-9 2017 IS and IAA showed positive association with MDA/FRAP corrected for uric acid, whereas IS and p-CS showed positive association with IL-6. p-cs 93-97 interleukin 6 Homo sapiens 131-135 28713941-5 2017 Celecoxib and simvastatin alone as well as a combined treatment showed a significant reduction in tumor cell viability, proliferation and secretion of IL-6 and IL-8 compared to the control group. Celecoxib 0-9 interleukin 6 Homo sapiens 151-155 28702667-8 2017 Furthermore, MPTCs secreted higher levels of pro-inflammatory interleukin-6 (IL-6) cytokine and C-reactive protein (CRP) than MPCCs. mptcs 13-18 interleukin 6 Homo sapiens 62-75 27557477-7 2017 By the addition of IL-6, mannitol transport was slightly increased in a concentration-dependent manner in both directions of absorption and efflux. Mannitol 25-33 interleukin 6 Homo sapiens 19-23 28955792-2 2017 Here, we showed a plant polyphenol, kaempferol, attenuated IL-6-induced COX-2 expression in human monocytic THP-1 cells suggesting its beneficial role in chronic inflammation. Polyphenols 24-34 interleukin 6 Homo sapiens 59-63 31249227-8 2019 Supplementation with high-dose Omega 3 resulted in a highly statistically significant decrease in total cholesterol, triglyceride, low-density lipoprotein, interleukin-6, C- reactive protein levels and a highly statistically significant increase in high-density lipoprotein (P <0.001). omega 3 31-38 interleukin 6 Homo sapiens 156-169 31037071-5 2019 Results: beta-Glucan-, oS100A4-, HMBG1-, and HSP90-pretreated monocytes showed increased IL-6 responses to LPS re-stimulation. beta-Glucans 9-20 interleukin 6 Homo sapiens 89-93 28702667-8 2017 Furthermore, MPTCs secreted higher levels of pro-inflammatory interleukin-6 (IL-6) cytokine and C-reactive protein (CRP) than MPCCs. mptcs 13-18 interleukin 6 Homo sapiens 77-81 28702667-9 2017 Treatment of MPCCs with HSC-conditioned culture medium confirmed that HSC secretions mediate the altered phenotype of PHHs observed in MPTCs, partly via IL-6 signaling. mptcs 135-140 interleukin 6 Homo sapiens 153-157 30962499-1 2019 This study aimed to explore the effect of dietary magnesium intake on breast cancer risk both directly and indirectly via its effect on inflammatory markers C-reactive protein (CRP) and interleukin-6 (IL-6). Magnesium 50-59 interleukin 6 Homo sapiens 186-199 30962499-1 2019 This study aimed to explore the effect of dietary magnesium intake on breast cancer risk both directly and indirectly via its effect on inflammatory markers C-reactive protein (CRP) and interleukin-6 (IL-6). Magnesium 50-59 interleukin 6 Homo sapiens 201-205 28811543-0 2017 4-(E)-{(p-tolylimino)-methylbenzene-1,2-diol} (TIMBD) suppresses HIV1-gp120 mediated production of IL6 and IL8 but not CCL5. 4-(E)-((p-tolylimino)-methylbenzene-1,2-diol) 0-44 interleukin 6 Homo sapiens 99-102 28800748-8 2017 High-dose application of taurolidine led to elevated liver enzymes and IL-6 secretion in hepatic organoid. taurolidine 25-36 interleukin 6 Homo sapiens 71-75 28515374-0 2017 Polyphyllin I Overcomes EMT-Associated Resistance to Erlotinib in Lung Cancer Cells via IL-6/STAT3 Pathway Inhibition. polyphyllin I 0-13 interleukin 6 Homo sapiens 88-92 28764778-11 2017 However, PBMC IL-6 and IL-1beta concentrations were increased at 0.05-0.2 mg/ml CLE but decreased at 0.4 mg/ml CLE (p < 0.0001). cle 80-83 interleukin 6 Homo sapiens 14-18 30777439-7 2019 Nanomolar concentrations of 2,8-DHQ significantly induced CYP1A1 expression and, upon cotreatment with cytokines, synergistically induced IL6 expression. 2,8-dihydroxyquinoline 28-35 interleukin 6 Homo sapiens 138-141 28198144-5 2017 The PE of EVOO decreased the frequency of CD69+ cells and the secretion of IFN-gamma, TNF-alpha, IL-6, IL-1beta, and IL-10. evoo 10-14 interleukin 6 Homo sapiens 97-101 30943938-9 2019 The SA group showed higher concentrations of Th1- (IL-6, TNF-alpha, IL-2, IFN-gamma) and Th2- (IL-4, and IL-10) related cytokines than the controls. sa 4-6 interleukin 6 Homo sapiens 51-55 32255011-0 2019 Bead-type polystyrene/nano-CaCO3 (PS/nCaCO3) composite: a high-performance adsorbent for the removal of interleukin-6. Calcium Carbonate 27-32 interleukin 6 Homo sapiens 104-117 30858902-11 2019 In the lipopolysaccharide-stimulated group, butyrate and docosahexaenoic acid attenuated IL-6 mRNA upregulation by lipopolysaccharide. Docosahexaenoic Acids 57-77 interleukin 6 Homo sapiens 89-93 28288151-5 2017 PTX markedly downregulated LPS-induced tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-6 levels in all age groups. Pentoxifylline 0-3 interleukin 6 Homo sapiens 96-100 28349446-2 2017 Hydroxychloroquine (HCQ) is an antimalarial agent and had a notable impact on immune activation by the reduction of circulating activated immune cells that including decreased TLR-expressing cells, reduced IFN-secreting DCs, reduced production of cytokines including IFN-alpha,IL-6 and TNF-alpha. Hydroxychloroquine 0-18 interleukin 6 Homo sapiens 277-281 28794655-10 2017 Further evidence indicated that P2Y12 and P2Y13 receptor-evoked increased gene expression of IL-1beta, IL-6 and TNF-alpha were inhibited by Y-27632 (ROCK inhibitor), SB203580 (P38MAPK inhibitor) and PDTC (NF-kappab inhibitor), respectively. Y 27632 140-147 interleukin 6 Homo sapiens 103-107 28794655-11 2017 Subsequently, P2Y12 and P2Y13 receptor-evoked release of IL-1beta, IL-6 and TNF-alpha, were also inhibited by Y-27632, SB203580 and PDTC, respectively. Y 27632 110-117 interleukin 6 Homo sapiens 67-71 30591403-6 2019 Cigarette smoke chemical components, such as benzo[alpha]pyrene, known as aryl hydrocarbon receptor (AhR) ligands, themselves activated NF-kappaB and induced proinflammatory cytokines, IL-1beta and IL-6. Benzo[alpha]pyrene 45-63 interleukin 6 Homo sapiens 198-202 28349446-2 2017 Hydroxychloroquine (HCQ) is an antimalarial agent and had a notable impact on immune activation by the reduction of circulating activated immune cells that including decreased TLR-expressing cells, reduced IFN-secreting DCs, reduced production of cytokines including IFN-alpha,IL-6 and TNF-alpha. Hydroxychloroquine 20-23 interleukin 6 Homo sapiens 277-281 30378703-10 2019 Significant increases in IL-6 levels were observed 24 hour-aBB (P < 0.001). ABB 59-62 interleukin 6 Homo sapiens 25-29 28740213-7 2017 Both IL-6 and TNF-alpha were lower at 1 h than at 4 h of the peritoneal equilibration test but the reductions in cytokine release were attenuated in AlaGln-supplemented samples. alanylglutamine 149-155 interleukin 6 Homo sapiens 5-9 28637505-7 2017 Salmeterol and formoterol exerted an inhibitory effect on the LPS-induced production of TNF-alpha, IL-6, CCL2, CCL3, and CCL4 in MDMs. Formoterol Fumarate 15-25 interleukin 6 Homo sapiens 99-103 28740213-8 2017 AlaGln-supplemented samples exhibited priming of IL-6-related pathways and downregulation of TNF-alpha upstream elements. alanylglutamine 0-6 interleukin 6 Homo sapiens 49-53 30428424-8 2019 RESULTS: Incubation with EPA and/or DHA attenuated inflammatory response to lipopolysaccharide (LPS) and monocyte co-culture with reduction in post-LPS mRNA expression and protein levels of IL6, CCL2 and CX3CL1. Docosahexaenoic Acids 36-39 interleukin 6 Homo sapiens 190-193 28482384-5 2017 Result: Compared with CVVH, HVHF had the capacity to improve significantly the index of Cdyn(HVHF (2.3+-0.5) vs. CVVH (1.5+-0.5) ml/(cmH(2)O kg), 1 cmH(2)O=0.098 kPa, P<0.05)and Rrs(HVHF (22.0+-1.9) vs.CVVH (29.5+-1.5) cmH(2)O/(L s), P<0.05)at the time of 6 h, and decreased lung water accumulation(index of EVLWI in HVHF (22.7+-2.1) vs.CVVH (39.5+-2.6) ml/m(2,) P<0.01) at the time of 6 h, and the plasma concentration of cytokines(IL-6, IL-10, TNF-alpha)in the HVHF group had an obvious decline compared with those in the CVVH group at the time of 6 h( (200+-55) vs. (280+-61), (74+-17) vs. (102+-21), (54+-13) vs. (73+-21) pg/ml, all P<0.05). cdyn 88-92 interleukin 6 Homo sapiens 442-446 28288142-7 2017 Unbiased large-scale metabolomic analysis and transcriptome-wide mRNA expression profiling identified reduced levels of several metabolites of the amino sugar and nucleotide sugar metabolic pathways, including sialic acid N-acetylneuraminic acid (Neu5Ac), and downregulation of pro-oncogenic cytokines interleukin-6 and 8 (IL-6 and IL-8) as unexpected outcomes of SHMT1 loss. N-Acetylneuraminic Acid 210-221 interleukin 6 Homo sapiens 323-327 28288142-9 2017 Supplementation of culture medium with Neu5Ac stimulated expression of IL-6 and IL-8 and rescued the tumor growth and migratory phenotypes of ovarian cancer cells expressing SHMT1 shRNAs. N-Acetylneuraminic Acid 39-45 interleukin 6 Homo sapiens 71-75 30674728-8 2019 Further, healthy PBMCs treated with IL-6 revealed a reduction in p-STAT3 following the addition of mycophenolic acid (the active metabolite of MMF). Mycophenolic Acid 99-116 interleukin 6 Homo sapiens 36-40 28195362-0 2017 Low-Intensity Ultrasound Enhances Histone Acetylation and Inhibition of Interleukin 6 Messenger RNA Expression by the Histone Deacetylase Inhibitor Sodium Butyrate in Fibroblasts. Butyric Acid 148-163 interleukin 6 Homo sapiens 72-85 30674728-8 2019 Further, healthy PBMCs treated with IL-6 revealed a reduction in p-STAT3 following the addition of mycophenolic acid (the active metabolite of MMF). Mycophenolic Acid 143-146 interleukin 6 Homo sapiens 36-40 28195362-6 2017 Therefore, the facilitative effects of low-intensity ultrasound on histone acetylation and interleukin 6 (IL-6) regulation by sodium butyrate were investigated in this study. Butyric Acid 126-141 interleukin 6 Homo sapiens 91-104 28195362-6 2017 Therefore, the facilitative effects of low-intensity ultrasound on histone acetylation and interleukin 6 (IL-6) regulation by sodium butyrate were investigated in this study. Butyric Acid 126-141 interleukin 6 Homo sapiens 106-110 30634931-13 2019 The increased renal protein or mRNA of TLR4 and proinflammatory mediators (IL-6 and MCP-1) in the unpretreated animals was significantly attenuated in the norfloxacin-pretreated animals. Norfloxacin 155-166 interleukin 6 Homo sapiens 75-79 30687316-11 2018 In addition, elevated level of miR-101-3p was found in AOSD patients with fever, sore throat and arthralgia symptoms; the miR-101-3p was also positively correlated with the levels of IL-6 and TNF-alpha in serum. mir-101-3p 31-41 interleukin 6 Homo sapiens 183-187 28430124-0 2017 Association between Serum Selenium Concentrations and Levels of Proinflammatory and Profibrotic Cytokines-Interleukin-6 and Growth Differentiation Factor-15, in Patients with Alcoholic Liver Cirrhosis. Selenium 26-34 interleukin 6 Homo sapiens 106-119 30687316-11 2018 In addition, elevated level of miR-101-3p was found in AOSD patients with fever, sore throat and arthralgia symptoms; the miR-101-3p was also positively correlated with the levels of IL-6 and TNF-alpha in serum. mir-101-3p 122-132 interleukin 6 Homo sapiens 183-187 31468464-9 2019 Most importantly, the stimulatory effect of ibuprofen on production of inflammatory cytokines (TNF-alpha, IL-6) was inhibited by all tested bromamines. bromamine 140-150 interleukin 6 Homo sapiens 106-110 28430124-2 2017 The aim of this study was to determine the relationship between the concentration of selenium and pro-inflammatory and profibrotic cytokines-interleukin-6 (IL-6) and growth differentiation factor 15 (GDF-15) in patients with alcoholic liver cirrhosis. Selenium 85-93 interleukin 6 Homo sapiens 131-154 28430124-2 2017 The aim of this study was to determine the relationship between the concentration of selenium and pro-inflammatory and profibrotic cytokines-interleukin-6 (IL-6) and growth differentiation factor 15 (GDF-15) in patients with alcoholic liver cirrhosis. Selenium 85-93 interleukin 6 Homo sapiens 156-160 28430124-5 2017 Moreover, the concentration of selenium negatively correlated with the levels of GDF-15 and IL-6. Selenium 31-39 interleukin 6 Homo sapiens 92-96 28019133-8 2017 A relationship was detected between H score, FSH, LH, total testosterone, HDL-C and TG levels and CG + GG genotypes of IL-6. cysteinylglycine 98-100 interleukin 6 Homo sapiens 119-123 30612458-4 2019 In vitro, LSE and its purified compound (-)-epigallocatechin (EGC) dose-dependently inhibited the expressions of pro-inflammatory cytokines and mediators, including tumor necrosis factor (TNF)- alpha , interleukin (IL)-6, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), without affecting cell viability in LPS-stimulated human hepatoma cell line HepG2. gallocatechol 40-60 interleukin 6 Homo sapiens 202-220 30612458-4 2019 In vitro, LSE and its purified compound (-)-epigallocatechin (EGC) dose-dependently inhibited the expressions of pro-inflammatory cytokines and mediators, including tumor necrosis factor (TNF)- alpha , interleukin (IL)-6, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), without affecting cell viability in LPS-stimulated human hepatoma cell line HepG2. gallocatechol 62-65 interleukin 6 Homo sapiens 202-220 30407866-6 2019 On the contrary, challenge with supraphysiological concentrations (10-25 mM), as might be used therapeutically, of propionate or butyrate in combination with TNFalpha resulted in substantially greater IL-6 and CXCL8 release from HLFs and ASM cells than challenge with TNFalpha alone, demonstrating synergistic effects. Propionates 115-125 interleukin 6 Homo sapiens 201-205 28049968-0 2017 Polyacrylic resins regulate transcriptional control of interleukin-6, gp80, and gp130 genes in human gingival fibroblasts. polyacrylic 0-11 interleukin 6 Homo sapiens 55-68 30399404-12 2019 IL-6 response to stress was buffered among high ACE women with high intake of docosahexaenoic acid (DHA) (p = 0.03) and eicosapentaenoic acid (EPA) (p = 0.05). Docosahexaenoic Acids 78-98 interleukin 6 Homo sapiens 0-4 30399404-12 2019 IL-6 response to stress was buffered among high ACE women with high intake of docosahexaenoic acid (DHA) (p = 0.03) and eicosapentaenoic acid (EPA) (p = 0.05). Docosahexaenoic Acids 100-103 interleukin 6 Homo sapiens 0-4 29993265-9 2019 Given that limited trials have focused on EPA or DHA intervention on concentrations of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha, further RCTs should be explored on these inflammatory factors. Docosahexaenoic Acids 49-52 interleukin 6 Homo sapiens 87-105 28704820-7 2017 RESULTS: Subjects who were beta-carotene-deficient (23.1% of the studied children) had higher IL-6 levels than subjects with normal beta-carotene concentrations. beta Carotene 27-40 interleukin 6 Homo sapiens 94-98 31032775-6 2019 RESULTS: Compared with the control group, IL-6, TNF-alpha and Cox-2 significantly increased in BeWo cells which were exposed in 50 nmol/L DON in 3, 12 and 24 h(P<0. DONS 138-141 interleukin 6 Homo sapiens 42-46 28704820-8 2017 The log-IL-6 and log-hs-CRP concentrations, but not the log-TNF-alpha level, were strongly and inversely related to the plasma log-beta-carotene level (taking into account log-age, energy intake, log-triglycerides, gender, log-body mass index, log-beta-carotene intake, energy from lipids and cholesterol as covariables). beta Carotene 131-144 interleukin 6 Homo sapiens 8-12 30516819-11 2018 The synthesis, signaling, and ocular surface cytokine concentration of IL-6 may be related to susceptibility to CIE. chlorimuron ethyl 112-115 interleukin 6 Homo sapiens 71-75 28704820-9 2017 When the 3 inflammatory biomarkers were introduced into the regression model along with the corresponding covariables, only the log-IL-6 level was related to the plasma log-beta-carotene level (beta = -0.505 +- 0.078; p < 0.001). beta Carotene 173-186 interleukin 6 Homo sapiens 132-136 28704820-10 2017 CONCLUSIONS: Inflammatory status, in particular IL-6 levels, appears to be negatively associated with plasma beta-carotene levels in schoolchildren. beta Carotene 109-122 interleukin 6 Homo sapiens 48-52 28785380-6 2017 Ginkgolide B also reduced the levels of platelet endothelial cell adhesion molecule-1, interleukin-6, and monocyte chemotactic protein 1. ginkgolide B 0-12 interleukin 6 Homo sapiens 87-100 30506883-5 2018 Our results demonstrated that ADMA inhibits insulin sensitivity in a concentration-dependent manner by activating inflammation factors tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, and IL-6 in primary hepatocytes. N,N-dimethylarginine 30-34 interleukin 6 Homo sapiens 194-198 28066425-8 2016 Transfecting neonatal monocytes with a let-7b-5p mimic resulted in a reduction of LPS-induced interleukin (IL)-6 and TNF-alpha production, while transfection of a let-7b-5p inhibitor into adult monocytes enhanced IL-6 and TNF-alpha production. let-7b-5p 39-48 interleukin 6 Homo sapiens 213-217 30160053-8 2018 Increased production of IL-6 is observed in the CD11c+ cells isolated from the PPs of P-Fag e 2-fed mice. Pentosan Sulfuric Polyester 79-82 interleukin 6 Homo sapiens 24-28 30160053-8 2018 Increased production of IL-6 is observed in the CD11c+ cells isolated from the PPs of P-Fag e 2-fed mice. p-fag 86-91 interleukin 6 Homo sapiens 24-28 27539101-5 2016 Many significant associations were found between the increase of IL-6, resp. SAA and the amounts of n-6 polyunsaturated fatty acids (namely linoleic, dihomo-gamma-linolenic, docosatetraenoic and docosapentaenoic acid), resp. saturated fatty acids (pentadecanoic, stearic, nonadecanoic) in erythrocyte membranes. dihomo-gamma-linolenic 150-172 interleukin 6 Homo sapiens 65-69 30373255-5 2018 Even better separation of benzene exposed workers and referents was observed for short-term exposure for genes in the Jak-STAT pathway, particularly elevated expression of IL6 and reduced expression of IL19. Benzene 26-33 interleukin 6 Homo sapiens 172-175 27390295-10 2016 Expression of both ATX and IL-6 was increased in SSc skin, and LPA-induced IL-6 levels and IL-6-induced ATX levels were increased in fibroblasts from SSc patients compared with controls. lysophosphatidic acid 63-66 interleukin 6 Homo sapiens 75-79 27680872-9 2016 Furthermore, the expression of IL-6 and IL-8 increased in LPA-stimulated human primary granulosa cells (P < .01). lysophosphatidic acid 58-61 interleukin 6 Homo sapiens 31-35 30347644-5 2018 DHA was more effective in reducing the levels of the DEP-induced release of the cytokines, especially IL-6 after 48 h of DEP exposure in comparison to EPA (p < 0.05), whereas EPA seemed to be more potent in reducing ET-1 levels. Docosahexaenoic Acids 0-3 interleukin 6 Homo sapiens 102-106 27680872-10 2016 Co-stimulation with rPEDF decreased the expression of LPA-induced IL-6 and IL-8 mRNA and protein by 4- and 2- to 5-fold, respectively. lysophosphatidic acid 54-57 interleukin 6 Homo sapiens 66-70 30302278-5 2018 Western blot analysis showed that YL064 inhibited the constitutive activation and IL-6-induced activation of STAT3, reflected by the decreased phosphorylation of STAT3 on Tyr705. yl064 34-39 interleukin 6 Homo sapiens 82-86 27874084-6 2016 Moreover, silymarin attenuated CSE-induced upregulation of inflammatory cytokines TNF-alpha, IL-6 and IL-8 which could also be dampened by ERK/p38 MAPK inhibitors and siRNAs for Beclin-1 and Atg5. Silymarin 10-19 interleukin 6 Homo sapiens 93-97 29983334-5 2018 Here, we show that primary human monocytes stimulated with Shiga toxin 1a (Stx1a) through the glycolipid receptor globotriaosylceramide released larger amounts of proinflammatory molecules (IL-1beta, TNFalpha, IL-6, G-CSF, CXCL8, CCL2, CCL4) than Stx1a-treated neutrophils. globotriaosylceramide 114-135 interleukin 6 Homo sapiens 210-214 27535971-2 2016 We reported Bazedoxifene, which is approved as a selective estrogen modulator by FDA, as a novel inhibitor of IL6/GP130 protein-protein interactions using multiple ligand simultaneous docking and drug repositioning approaches. bazedoxifene 12-24 interleukin 6 Homo sapiens 110-113 29786910-4 2018 Experiments in lipopolysaccharide (LPS)-activated BV2 microglia showed that pretreatment with agathisflavone (5-20 muM) produced significant reduction in the release of tumour necrosis factor-alpha, interleukin-6, interleukin-1beta, NO, and PGE2 from the cells. agathisflavone 94-108 interleukin 6 Homo sapiens 199-212 28761837-7 2017 Interleukin-6 expression was downregulated subsequent to treatment with 316L-SS compared to the control group. 316l-ss 72-79 interleukin 6 Homo sapiens 0-13 27535971-4 2016 Here, we observed Bazedoxifene inhibited STAT3 phosphorylation and STAT3 DNA binding, induced apoptosis, and suppressed tumor growth in pancreatic cancer cells with persistent IL6/GP130/STAT3 signaling in vitro and in vivo In addition, IL6, but not INFgamma, rescued Bazedoxifene-mediated reduction of cell viability. bazedoxifene 18-30 interleukin 6 Homo sapiens 176-179 30022657-4 2018 First, graphene oxides (GO) were loaded with redox probes nile blue (NB), methyl blue (MB), and ferrocene (Fc), followed by covalent attachment of anti-cytokine antibodies for IL-6, IL-1beta, and TNF-alpha, respectively, to obtain Ab2-GO-NB, Ab2-GO-MB, and Ab2-GO-Fc, acting as the signal reporters. graphene oxide 7-22 interleukin 6 Homo sapiens 176-180 30022657-4 2018 First, graphene oxides (GO) were loaded with redox probes nile blue (NB), methyl blue (MB), and ferrocene (Fc), followed by covalent attachment of anti-cytokine antibodies for IL-6, IL-1beta, and TNF-alpha, respectively, to obtain Ab2-GO-NB, Ab2-GO-MB, and Ab2-GO-Fc, acting as the signal reporters. graphene oxide 24-26 interleukin 6 Homo sapiens 176-180 27535971-4 2016 Here, we observed Bazedoxifene inhibited STAT3 phosphorylation and STAT3 DNA binding, induced apoptosis, and suppressed tumor growth in pancreatic cancer cells with persistent IL6/GP130/STAT3 signaling in vitro and in vivo In addition, IL6, but not INFgamma, rescued Bazedoxifene-mediated reduction of cell viability. bazedoxifene 18-30 interleukin 6 Homo sapiens 236-239 27535971-5 2016 Bazedoxifene also inhibited STAT3 phosphorylation induced by IL6 and IL11, but not by OSM or STAT1 phosphorylation induced by INFgamma in pancreatic cancer cells, suggesting that Bazedoxifene inhibits the GP130/STAT3 pathway mediated by IL6 and IL11. bazedoxifene 0-12 interleukin 6 Homo sapiens 61-64 27390979-7 2016 RESULTS: There were significant reduction in the levels of the interleukin-6 and cardiac troponin-I in the trimetazidine-treated group (group 2) compared to the control group (group 1) (P<0.001), after 12h and 24h post-operative. Trimetazidine 107-120 interleukin 6 Homo sapiens 63-76 29784660-5 2018 beta-Cell-specific loss of IL-6 signaling in vivo renders mice more susceptible to oxidative damage and cell death through the selective beta-cell toxins streptozotocin and alloxan. Alloxan 173-180 interleukin 6 Homo sapiens 27-31 28177661-8 2017 Furthermore, DAB suppressed the production of tumor necrosis factor-alpha (TNF-alpha) or interleukin (IL)-6 and the activation of nuclear factor-kappaB (NF-kappaB) or extracellular regulated kinases (ERK) 1/2 by LPS. dabrafenib 13-16 interleukin 6 Homo sapiens 89-107 28558818-10 2017 Transfection of miR-101a into microglia significantly increased the production of IL-6 in response to LPS. mir-101a 16-24 interleukin 6 Homo sapiens 82-86 26771135-11 2016 CONCLUSIONS: Higher levels of TNF-alpha, IL-6, and IL-1beta might predict nonresponse to fluoxetine treatment in children. Fluoxetine 89-99 interleukin 6 Homo sapiens 41-45 28420169-0 2017 Ultrasensitive Label-Free Sensing of IL-6 Based on PASE Functionalized Carbon Nanotube Micro-Arrays with RNA-Aptamers as Molecular Recognition Elements. pase 51-55 interleukin 6 Homo sapiens 37-41 28758428-6 2018 In addition, SDAPR treatment markedly inhibited the levels of TNF-alpha and IL-6. sdapr 13-18 interleukin 6 Homo sapiens 76-80 28420169-3 2017 Nanotube biosensors were functionalized with 1-Pyrenebutanoic Acid Succinimidyl Ester (PASE) conjugated IL-6 aptamers. pase 87-91 interleukin 6 Homo sapiens 104-108 27649298-0 2016 S-Propargyl-Cysteine, a Novel Hydrogen Sulfide Donor, Inhibits Inflammatory Hepcidin and Relieves Anemia of Inflammation by Inhibiting IL-6/STAT3 Pathway. S-propargylcysteine 0-20 interleukin 6 Homo sapiens 135-139 28420169-8 2017 Non-specific BSA did not produce any appreciable shift in the Ids versus Vg suggesting specific interactions of IL-6 on PASE conjugated aptamer surface gave rise to the change in electrical signal. pase 120-124 interleukin 6 Homo sapiens 112-116 29709093-7 2018 Magnesium sulfate administered 1-hour post-LPS inhibited FM secretion of IL-1beta, IL-6, G-CSF, RANTES, and TNFalpha. Magnesium Sulfate 0-17 interleukin 6 Homo sapiens 83-87 29473951-7 2018 By contrast, low concentrations of 4-HNE, niacin and 3-OHBA down-regulated the expression of pro-inflammatory cytokines IL-6 and IL-8. 4-hydroxy-2-nonenal 35-40 interleukin 6 Homo sapiens 120-124 27060359-8 2016 Furthermore, UA significantly downregulated phosphorylated ERK1/2 (where ERK is extracellular signal-regulated kinase) while decreasing interleukin 6 level and elevating PPAR-gamma. 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one 13-15 interleukin 6 Homo sapiens 136-149 29630729-0 2018 Rho-kinase inhibitor Y-27632 downregulates LPS-induced IL-6 and IL-8 production via blocking p38 MAPK and NF-kappaB pathways in human gingival fibroblasts. Y 27632 21-28 interleukin 6 Homo sapiens 55-59 29630729-13 2018 CONCLUSIONS: Rho-kinase inhibitor Y-27632 downregulates LPS-induced IL-6 and IL-8 production by blocking NF-kappaB and p38 MAPK activation in HGFs. Y 27632 34-41 interleukin 6 Homo sapiens 68-72 29635790-0 2018 Popolohuanones G - I, Dimeric Sesquiterpene Quinones with IL-6 Inhibitory Activity from the Marine Sponge Dactylospongia elegans. popolohuanones 0-14 interleukin 6 Homo sapiens 58-62 28242843-11 2017 Furthermore, human peripheral monocytes incubated with HepAD38 (dox-)-exo induced a significantly lower level of IL-6 secretion compared with IL-6 levels from HepAD38 (dox+)-exo. Doxycycline 64-67 interleukin 6 Homo sapiens 113-117 28242843-11 2017 Furthermore, human peripheral monocytes incubated with HepAD38 (dox-)-exo induced a significantly lower level of IL-6 secretion compared with IL-6 levels from HepAD38 (dox+)-exo. Doxycycline 168-171 interleukin 6 Homo sapiens 142-146 28242843-12 2017 Irreversible inhibition of proteasomal activity within exosomes restored higher production of IL-6 by monocytes, suggesting that transmission of proteasome subunit proteins by HepAD38 (dox-)-exo might modulate the production of pro-inflammatory molecules in the recipient monocytes. Doxycycline 185-188 interleukin 6 Homo sapiens 94-98 29635790-0 2018 Popolohuanones G - I, Dimeric Sesquiterpene Quinones with IL-6 Inhibitory Activity from the Marine Sponge Dactylospongia elegans. grayanotoxin I 15-20 interleukin 6 Homo sapiens 58-62 27422559-5 2016 RESULTS: GMSYS significantly inhibited the LPS-induced production of NO, PGE2, TNF-alpha, and IL-6 compared with the vehicle-treated cells. gmsys 9-14 interleukin 6 Homo sapiens 94-98 30083334-8 2018 Notably, necrostatin-1, the specific inhibitor of the RIP3 signaling pathway, and 6-thioguanine (6-TG), the active metabolite of azathioprine, predominantly reduced IL-6 production compared to other cytokines. Azathioprine 129-141 interleukin 6 Homo sapiens 165-169 29861448-7 2018 Data also revealed a reduction in plasma human leukocyte elastase (pHLE) complexes and interleukin-6 (IL-6) expression levels in blood samples of MAG-DHA supplemented CF patients. Docosahexaenoic Acids 150-153 interleukin 6 Homo sapiens 87-100 29861448-7 2018 Data also revealed a reduction in plasma human leukocyte elastase (pHLE) complexes and interleukin-6 (IL-6) expression levels in blood samples of MAG-DHA supplemented CF patients. Docosahexaenoic Acids 150-153 interleukin 6 Homo sapiens 102-106 29861448-8 2018 This pilot study indicates that MAG-DHA supplementation corrects erythrocyte AA/DHA imbalance and may exert anti-inflammatory properties through the reduction of pHLE complexes and IL6 in blood samples of CF patients. Docosahexaenoic Acids 36-39 interleukin 6 Homo sapiens 181-184 28450957-5 2017 Following 131I therapy, the serum levels of IL-6 and CXCL-10 in patients with GD were markedly increased within the first week, gradually decreased to the pretreatment level in the subsequent six months and decreased further at 18 months post-treatment. Iodine-131 10-14 interleukin 6 Homo sapiens 44-48 28450957-6 2017 However, the serum levels of IL-6 and CXCL-10 in patients with GD at 18 months following 131I therapy remained significantly higher than in control subjects (P<0.01). Iodine-131 89-93 interleukin 6 Homo sapiens 29-33 28178994-16 2017 Treatment of breast cancer cells with doxycycline also decreased the translocation of NF-kappaB to the nucleus and the mRNA levels for IL-6 in the presence or absence of lysophosphatidate. Doxycycline 38-49 interleukin 6 Homo sapiens 135-139 26546554-10 2016 Furthermore, aluminum altered TNFalpha, IL1beta, IL6, and IL10 mRNA levels as well. Aluminum 13-21 interleukin 6 Homo sapiens 49-52 27836733-7 2017 BAY11-7028, the inhibitor of NF-kappaB, can mimic the effect of G-1 to suppression of IL-6 and VEGF-A. bay11-7028 0-10 interleukin 6 Homo sapiens 86-90 29477354-6 2018 The transcript levels of IL-6 were significantly lower in the TCE exposure groups including patients and exposure workers as compared to the unexposed controls (P < 0.0001 and P = 0.0008). Trichloroethylene 62-65 interleukin 6 Homo sapiens 25-29 29477354-9 2018 There was a significantly positive correlation between the plasma levels IL-6 and IL-10 in TCE exposed workers. Trichloroethylene 91-94 interleukin 6 Homo sapiens 73-77 29477354-11 2018 Therefore, the elevation of IL-10 level may be a kind of pathogenesis indicator, and the decline in IL-6 level may be a kind of TCE exposure biomarker. Trichloroethylene 128-131 interleukin 6 Homo sapiens 100-104 27102438-6 2016 Furthermore, wogonoside dramatically decreased the secretion and expression of IL-1beta, IL-6 and TNF-alpha as well as the nuclear expression of NF-kappaB in adenomas and surrounding tissues. wogonoside 13-23 interleukin 6 Homo sapiens 89-93 29735019-6 2018 RESULTS: EPA+DHA therapy had a significant lowering effect on levels of IL-6, IL-1beta and TNF-alpha after 4 weeks of therapy and an even greater lowering effect after 8 weeks of therapy. Docosahexaenoic Acids 13-16 interleukin 6 Homo sapiens 72-76 28056977-8 2017 The pro-inflammatory cytokines IL-6 and IL-1beta were greatly decreased in the LPS + Corilagin group both in supernatant and serum (P < 0.01). corilagin 85-94 interleukin 6 Homo sapiens 31-35 26268146-5 2016 The in vitro literature on antidepressants shows that some antidepressants, such as clomipramine and fluoxetine, more consistently decrease pro-inflammatory cytokines (interleukin (IL)-6, interferon (IFN)-gamma, tumour necrosis factor (TNF)-alpha), whilst others (mirtazapine and venlafaxine) tend to increase their levels. Fluoxetine 101-111 interleukin 6 Homo sapiens 168-186 27840060-10 2017 None of these effects were evident in blank LP-exposed cells and non-LP MPA formulation reduced only IL-6 production. leucylproline 69-71 interleukin 6 Homo sapiens 101-105 29674687-10 2018 Similarly, celecoxib prevented IL-1beta-mediated induction of IL-6. Celecoxib 11-20 interleukin 6 Homo sapiens 62-66 29615908-7 2018 Acetate, butyrate and propionate reduced IL-6 and IL-8 levels and the magnitude was dependent on the incubation times. Propionates 22-32 interleukin 6 Homo sapiens 41-45 29615908-12 2018 Conclusion: SCFA, including acetate, butyrate and propionate, influenced LPS- or TNFalpha-induced endothelial activation by inhibiting the production of IL-6 and IL-8, and reducing the expression of VCAM-1 and subsequent cell adhesion. Propionates 50-60 interleukin 6 Homo sapiens 153-157 27090981-8 2016 Furthermore, HM71224 effectively inhibited the production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-1beta by human monocytes, and osteoclast formation by human monocytes. Poseltinib 13-20 interleukin 6 Homo sapiens 96-114 29274621-5 2018 The hypothesis of this study was that cannabinoids anandamide (AEA), HU-308 (CB2R selective agonist), and SMM-189 decrease pro-inflammatory IL-6 and MCP-1 production by primary human periodontal ligament fibroblasts (hPDLFs) stimulated with P. gingivalis LPS, TNF-alpha, or IL-1beta. HU 308 69-75 interleukin 6 Homo sapiens 140-144 29466985-8 2018 Among subjects without insulin resistance there was a positive association between stearic fatty acid and IL-6 (p = 0.032), and a negative association between alpha-linolenic fatty acid and pro-inflammatory biomarkers (p < 0.05). stearic fatty acid 83-101 interleukin 6 Homo sapiens 106-110 28243360-10 2017 Accordingly, polyphenols decreased IL-1beta and IL-6 release in comparison to H controls. Polyphenols 13-24 interleukin 6 Homo sapiens 48-52 32263018-3 2016 This study demonstrated that conjugation of a corticosteroid (triamcinolone) on polyethylene-glycol (PEG)-fabricated multi-walled carbon nanotubes enhances intracellular drug delivery via increased lysosome transport and ultimately suppresses the expression of major pro-inflammatory cytokines (i.e., TNF-alpha, IL-1beta, and IL-6) and matrix metalloproteinase-1 and -3 from fibroblast-like synoviocytes at a very low drug dose. Triamcinolone 62-75 interleukin 6 Homo sapiens 326-330 28217046-7 2017 Furthermore, TNF-alpha, IL-1beta, and IL-6 were significantly reduced after budesonide nebulizations. Budesonide 76-86 interleukin 6 Homo sapiens 38-42 28217046-9 2017 CONCLUSION: Nebulized budesonide improved oxygenation, peak, and plateau airway pressures and significantly reduced inflammatory markers (TNF-alpha, IL-1beta and IL-6) without affecting hemodynamics. Budesonide 22-32 interleukin 6 Homo sapiens 162-166 29117589-6 2018 Additionally, long-term exposure of MC-LR at low concentration remarkably promoted the expression of NF-kappaB p65, COX-2, iNOS, TNF-alpha, IL-1beta, and IL-6 in the cells, suggesting that long-term MC-LR exposure at low concentration can induce inflammatory reaction to HepG2 cells, which might account for MC-induced human hepatitis. cyanoginosin LR 36-41 interleukin 6 Homo sapiens 154-158 26826613-0 2016 Effects of the SLCO1B1 *1 and SLCO1B1 *5 polymorphisms on IL-6 and IL-10 levels in patients under pravastatin treatment prior to inguinal hernia repair. Pravastatin 98-109 interleukin 6 Homo sapiens 58-62 29207018-0 2018 Clinical significance of interleukin-6 and inducible nitric oxide synthase in ketamine-induced cystitis. Ketamine 78-86 interleukin 6 Homo sapiens 25-38 29207018-8 2018 The results indicated that the expression levels of interleukin-6 and inducible nitric oxide synthase (iNOS) were decreased, whereas collagen expression and deposition were increased in ketamine-treated SMCs. Ketamine 186-194 interleukin 6 Homo sapiens 52-65 30303416-8 2018 RESULTS: Serum IL-6 concentrations increased significantly immediately after LBH in all the three groups. SCHEMBL20232415 77-80 interleukin 6 Homo sapiens 15-19 27773804-0 2016 Aliskiren attenuates the effects of interleukin-6 on endothelial nitric oxide synthase and caveolin-1 in human aortic endothelial cells. aliskiren 0-9 interleukin 6 Homo sapiens 36-49 27773804-3 2016 In this study, we examined the effects of pretreatment with aliskiren on the changes of IL-6-induced expression and activation of eNOS and caveolin-1 in cultured HAECs. aliskiren 60-69 interleukin 6 Homo sapiens 88-92 27773804-5 2016 Pretreatment with aliskiren attenuated the inhibitory effects of IL-6 on eNOS phosphorylation and nitric oxide production. aliskiren 18-27 interleukin 6 Homo sapiens 65-69 27773804-7 2016 Pretreatment with aliskiren attenuated the effects of IL-6 on caveolin-1 phosphorylation. aliskiren 18-27 interleukin 6 Homo sapiens 54-58 27773804-10 2016 In conclusion, aliskiren attenuates the inhibitory effects of IL-6 on eNOS phosphorylation and nitric oxide production and IL-6 induced caveolin-1 phosphorylation. aliskiren 15-24 interleukin 6 Homo sapiens 62-66 27773804-11 2016 In addition, aliskiren reverses the effects of IL-6 on the eNOS-caveolin-1 interaction. aliskiren 13-22 interleukin 6 Homo sapiens 47-51 28033321-0 2016 Atorvastatin, Losartan and Captopril Lead to Upregulation of TGF-beta, and Downregulation of IL-6 in Coronary Artery Disease and Hypertension. Losartan 14-22 interleukin 6 Homo sapiens 93-97 26810262-2 2016 Among different compounds screened, compound 4d was emerged as the most potent IL-6 signaling blockers with IC50 value of 5.9 muM which was much better than (+)-Madindoline A (IC50=21 muM), a known inhibitor of IL-6. madindoline A 157-174 interleukin 6 Homo sapiens 79-83 30078834-0 2018 Polyhexamethylene guanidine phosphate induces IL-6 and TNF-alpha expression through JNK-dependent pathway in human lung epithelial cells. polyhexamethyleneguanidine 0-37 interleukin 6 Homo sapiens 46-50 26810262-2 2016 Among different compounds screened, compound 4d was emerged as the most potent IL-6 signaling blockers with IC50 value of 5.9 muM which was much better than (+)-Madindoline A (IC50=21 muM), a known inhibitor of IL-6. madindoline A 157-174 interleukin 6 Homo sapiens 211-215 27782292-5 2016 DMA significantly attenuated the secretion of TNFalpha, IL-6, IL-10, and granulocyte macrophage colony stimulating factor (GM-CSF) from LPS-stimulated RAW 264.7 cells, IL-6 secretion from TNFalpha-stimulated JEG-3 cells and TNFalpha, IL-6, IL-10, GM-CSF and Interleukin-8 (IL-8) from LPS-stimulated human placental explants. dimethylacetamide 0-3 interleukin 6 Homo sapiens 168-172 26673245-5 2016 Furthermore, calprotectin AUCi was positively correlated with IL-6 AUCi and MPO AUCi, even after controlling for BMI. calprotectin auci 13-30 interleukin 6 Homo sapiens 62-66 27358258-8 2016 The effects of particulate beta-glucan induced TLR4 binding were regulatory as blocking TLR4 enhanced pro-inflammatory cytokine IL-23, IL-4, IL-6, and TNF-alpha production. beta-Glucans 27-38 interleukin 6 Homo sapiens 141-145 28914726-10 2018 From pretreatment to posttreatment, CBTI-BP compared with psychoeducation was associated with a nonsignificant, large effect size decrease in IL-6 (z = -1.61, p = .13, d = -0.78) and a nonsignificant, small-medium effect size decrease in sTNF-R2 (z = -0.79, p = .44, d = -0.38). Benzo(a)pyrene 41-43 interleukin 6 Homo sapiens 142-146 30029729-4 2018 Clinical, epidemiological, and experimental studies indicate that DHEA replacement therapy may be beneficial for bone health through its inhibition of skeletal catabolic IL-6 and stimulation of osteoanabolic IGF-I-mediated mechanisms. Dehydroepiandrosterone 66-70 interleukin 6 Homo sapiens 170-174 30029729-7 2018 The in vitro inhibition of IL-6 secretion in hMSCs by DHEA was more consistent and extensive than by estradiol or dihydrotestosterone. Dehydroepiandrosterone 54-58 interleukin 6 Homo sapiens 27-31 29594564-0 2017 Photoelectrochemical immunoassay for human interleukin 6 based on the use of perovskite-type LaFeO3 nanoparticles on fluorine-doped tin oxide glass. stannic oxide 132-141 interleukin 6 Homo sapiens 43-56 28243294-0 2016 Randomized Trial of the Effect of Magnesium Sulfate Continuous Infusion on IL-6 and CRP Serum Levels Following Abdominal Aortic Aneurysm Surgery. Magnesium Sulfate 34-51 interleukin 6 Homo sapiens 75-79 27738630-2 2016 To evaluate the association of -174G/C IL-6 polymorphism with failure in therapeutic response to methotrexate (MTX) or leflunomide (LEF). Leflunomide 132-135 interleukin 6 Homo sapiens 39-43 28243294-4 2016 In this study, we aimed to investigate the impact of Mg loading following AAA surgery on two inflammation markers, IL-6 and CRP, as well as patient"s outcome. Magnesium 53-55 interleukin 6 Homo sapiens 115-127 28243294-10 2016 However, IL-6 level was significantly less in intervention group early after the end of MgSO4 infusion comparing with control group (P = 0.01). Magnesium Sulfate 88-93 interleukin 6 Homo sapiens 9-13 27889747-9 2016 Besides, inflammatory cytokines TNF-alpha, IL-6 levels were markedly inhibited by Alisol A 24-acetate. alisol A 24-acetate 82-101 interleukin 6 Homo sapiens 43-47 28243294-13 2016 According to the results of this study, continuous infusion of MgSO4 after AAA surgery may provide IL-6 suppression. Magnesium Sulfate 63-68 interleukin 6 Homo sapiens 99-103 27324144-8 2016 Angiographic reperfusion (TMPG 0/1 vs 2/3) was associated with changes in median NT-proBNP (2649.3, 1382.7 ng/mL; p = 0.002) and IL-6 (28.7, 15.1; p = 0.040). N(2)-(3-trifluoromethylphenyl)guanine 26-30 interleukin 6 Homo sapiens 129-133 29233145-8 2017 Our study raises caution over the use of anti-IL-6 antibody or pentoxifylline to reduce IL-6 for patient treatment. Pentoxifylline 63-77 interleukin 6 Homo sapiens 88-92 29272001-13 2017 After the intervention of PGE2 and Butaprost, great increases were seen in the cell proliferation rate, invasion capability, and the expression of MMP-9, VEGF, IL-6, and TNF-alpha in EC109 and TE-1 cell strains (p < 0.05), however, the intervention of RNAi could reduce above indexes (p < 0.05). butaprost 35-44 interleukin 6 Homo sapiens 160-164 26613980-5 2016 RESULTS: AMBMP induced the rapid phosphorylation of NFkappaB p65 at Ser(536) and abrogated total IkappaB, accompanied by a subsequent increase in pro-inflammatory cytokine production (TNF, IL-6, IL-12 p40) in otherwise naive monocytes. 2-amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine 9-14 interleukin 6 Homo sapiens 189-193 31608209-8 2017 His signs and symptoms improved after treatment with methylprednisolone and tocilizumab (anti-IL-6 receptor antibody). Methylprednisolone 53-71 interleukin 6 Homo sapiens 94-98 27422754-12 2016 Combined but not single blockade of GM-CSF-receptor-alpha-chain and IL-6 reduced TNFalpha- and ET-1-induced HASMC proliferation and DNA-synthesis. hasmc 108-113 interleukin 6 Homo sapiens 68-72 27422754-14 2016 In conclusion, TNFalpha induces HASMC proliferation via ET-1/GM-CSF/IL-6. hasmc 32-37 interleukin 6 Homo sapiens 68-72 27820923-5 2016 NO2 exposure resulted in a concentration-dependent release of IL-6, but not IL-8 release. Nitrogen Dioxide 0-3 interleukin 6 Homo sapiens 62-66 29132841-6 2017 Pg-3-glc and PGA at 0.08 mumol/L increased the concentration of IL-10 (P<.01 and P<.001, respectively), but there was no effect on tumor necrosis factor-alpha, IL-1beta, IL-6, and IL-8, and there were no effects of the other compounds. pelargonidin-3-glucoside 0-8 interleukin 6 Homo sapiens 176-180 27622570-4 2016 Proinflammatory cytokine IL-6 and TNF-alpha levels in response to stimulation with either the NOD1 agonist Tri-DAP or the NOD2 agonist MDP were significantly reduced after CPB compared with those before CPB, which is consistent with a suppressed inflammatory response postoperatively. L-Ala-gamma-D-Glu-meso-diaminopimelic acid 107-114 interleukin 6 Homo sapiens 25-29 27820923-6 2016 The coexposure of 0.1 ppm NO2 and Der p 1, or 1 ppm NO2 and Der p 1 significantly increased both IL-6 and IL-8 release. Nitrogen Dioxide 26-29 interleukin 6 Homo sapiens 97-101 27458080-6 2016 Dabrafenib suppressed the PolyP-mediated vascular barrier permeability, upregulation of inflammatory biomarkers, adhesion/migration of leukocytes, and activation and/or production of nuclear factor-kappaB, tumor necrosis factor-alpha, and interleukin-6. dabrafenib 0-10 interleukin 6 Homo sapiens 239-252 28477980-11 2017 ROS scavenger N-acetyl-L-cysteine (NAC) and Akt inhibitor MK2206 reduced TNF-alpha-induced mRNA expression of MCP-1 and IL-6 in VAFs. MK 2206 58-64 interleukin 6 Homo sapiens 120-124 28408143-7 2017 Both tetrandrine and methylprednisolone inhibited the secretion of pro-inflammatory cytokines TNFalpha and IL-6 significantly and the combination showed stronger inhibitory ability. Methylprednisolone 21-39 interleukin 6 Homo sapiens 107-111 27820923-6 2016 The coexposure of 0.1 ppm NO2 and Der p 1, or 1 ppm NO2 and Der p 1 significantly increased both IL-6 and IL-8 release. Nitrogen Dioxide 52-55 interleukin 6 Homo sapiens 97-101 27465323-2 2016 We described the clinical features of SLEAP, and discussed the feasibility of plasma exchange (PE) combined with glucocorticosteroids (GC) in short-term prognosis and possible mechanism in reducing serum inflammatory cytokine IL-6 and removing serum lipids. gallocatechol 135-137 interleukin 6 Homo sapiens 226-230 26655640-3 2015 Our results showed that dioscin significantly attenuated hepatic stellate cells (HSCs) activation, improved collagen accumulation, and attenuated inflammation through down-regulating the levels of myeloid differentiation factor 88 (MyD88), nuclear factor kappaB (NF-kappaB), interleukin (IL)-1, IL-6 and tumour necrosis factor-alpha by decreasing Toll-like receptor (TLR)4 expression both in vivo and in vitro. dioscin 24-31 interleukin 6 Homo sapiens 295-332 27163161-8 2016 We show that the hypoxia-IL6-p-STAT3-MIR155-3p-CREBRF-CREB3-ATG5 pathway plays a central role in malignant glioma progression, with blockade of the IL6 receptor by tocilizumab demonstrating a certain level of therapeutic efficacy in a xenograft model in vivo, especially in combination with temozolomide. Temozolomide 291-303 interleukin 6 Homo sapiens 25-28 27163161-8 2016 We show that the hypoxia-IL6-p-STAT3-MIR155-3p-CREBRF-CREB3-ATG5 pathway plays a central role in malignant glioma progression, with blockade of the IL6 receptor by tocilizumab demonstrating a certain level of therapeutic efficacy in a xenograft model in vivo, especially in combination with temozolomide. Temozolomide 291-303 interleukin 6 Homo sapiens 148-151 28736555-3 2017 We show that beta-glucan particle size is a critical factor contributing to the secretion of cytokines from human DC; large beta-glucan-stimulated DC generate significantly more IL-1beta, IL-6, and IL-23 compared to those stimulated with the smaller beta-glucans. beta-Glucans 13-24 interleukin 6 Homo sapiens 188-192 28736555-3 2017 We show that beta-glucan particle size is a critical factor contributing to the secretion of cytokines from human DC; large beta-glucan-stimulated DC generate significantly more IL-1beta, IL-6, and IL-23 compared to those stimulated with the smaller beta-glucans. beta-Glucans 124-135 interleukin 6 Homo sapiens 188-192 29062346-0 2017 Effect of low-dose ketamine on post-operative serum IL-6 production among elective surgical patients: a randomized clinical trial. Ketamine 19-27 interleukin 6 Homo sapiens 52-56 29062346-10 2017 Ketamine suppressed serum IL-6 at PACU with reduced increase at 24 hours. Ketamine 0-8 interleukin 6 Homo sapiens 26-30 26662445-0 2015 Effects of flurbiprofen axetil on postoperative serum IL-2 and IL-6 levels in patients with colorectal cancer. flurbiprofen axetil 11-30 interleukin 6 Homo sapiens 63-67 27768523-2 2017 However, the exercise-induced release of inflammatory cytokines including interleukin-6 (IL-6) may also contribute to the rise in TC by increasing the hypothalamic temperature set point. Technetium 130-132 interleukin 6 Homo sapiens 74-87 27768523-2 2017 However, the exercise-induced release of inflammatory cytokines including interleukin-6 (IL-6) may also contribute to the rise in TC by increasing the hypothalamic temperature set point. Technetium 130-132 interleukin 6 Homo sapiens 89-93 27639185-5 2017 VPA and lithium both induce significant down-regulation of group I CD1 expression and secretion of IL-6 during differentiation of human monocyte-derived immature DC, while they differ in the induction of CD83 and CD86 expression, secretion of IL-8, IL-10, and TNF-alpha. Lithium 8-15 interleukin 6 Homo sapiens 99-103 27207661-4 2016 In this study, we examined the mechanistic effects of a natural prenylflavonoid, icaritin (ICT), on neuroendocrine differentiation in IL-6-induced LNCaP cells and NEPC development in the male transgenic adenocarcinoma of the mouse prostate (TRAMP) model. icaritin 81-89 interleukin 6 Homo sapiens 134-138 27207661-4 2016 In this study, we examined the mechanistic effects of a natural prenylflavonoid, icaritin (ICT), on neuroendocrine differentiation in IL-6-induced LNCaP cells and NEPC development in the male transgenic adenocarcinoma of the mouse prostate (TRAMP) model. icaritin 91-94 interleukin 6 Homo sapiens 134-138 26662445-10 2015 Flurbiprofen axetil promoted the secretion of IL-2 and inhibited IL-6; additionally, flurbiprofen axetil may have a lower incidence of adverse reactions compared to other treatments. flurbiprofen axetil 0-19 interleukin 6 Homo sapiens 65-69 28966794-5 2017 RESULTS: Activation of monocytes from MS subjects produced significantly more IL-6 than healthy controls (49531 +- 20795 vs 10526 +- 4845), and IL-6 production trended higher in MS subjects taking DMF than those taking other DMDs (72186.9 +- 35156.2 vs 32585.8 +- 17135.4). Dimethyl Fumarate 197-200 interleukin 6 Homo sapiens 144-148 26553339-5 2015 In hypoxia and serum-deprived culture conditions, LPA induces CD34(+) cell proliferation without maintaining the their undifferentiating state, and enhances IL-8, IL-6 and G-CSF secretion during the first 12 h compared to non-treated cells. lysophosphatidic acid 50-53 interleukin 6 Homo sapiens 163-167 28491903-3 2017 We noted significant reductions in GM-CSF, TNF-alpha, and IL-6 producing B cells with DMF treatment. Dimethyl Fumarate 86-89 interleukin 6 Homo sapiens 58-62 27310431-0 2016 Correction to "IL-6 Antibody and RGD Peptide Conjugated Poly(amidoamine) Dendrimer for Targeted Drug Delivery of HeLa Cells". poly(amidoamine) dendrimer 56-82 interleukin 6 Homo sapiens 15-19 26999847-4 2015 CONCLUSION: IL-6 and other inflammatory factors may involved pathological physiological process in OSAHS patients sugar metabolic abnormalities; and is associated with the development of OSAHS associated with type 2 diabetes. Sugars 114-119 interleukin 6 Homo sapiens 12-16 26502273-5 2016 Under in vitro conditions graphene and GO cause an increased production of pro-inflammatory cytokines, mainly IL-1, IL-6, IL-10 and TNF-alpha, as a result of the activation of Toll-like receptors in macrophages. Graphite 26-34 interleukin 6 Homo sapiens 116-120 26564171-9 2016 In children, IL-6 levels were also higher in OSA (SMD = 1.27, 95 % CI = 0.29-2.26) and T&A treatment significantly decreased them (SMD = -0.97, 95 % CI = -1.72 to -0.22). t& 87-92 interleukin 6 Homo sapiens 13-17 28663607-2 2017 The aim of this study was to evaluate the effect of preincision single or multiple doses of S(+) ketamine on the pro-inflammatory cytokines, namely tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). Ketamine 92-105 interleukin 6 Homo sapiens 192-205 28663607-7 2017 The study also revealed that a single preincision dose of S(+) ketamine decreased TNF-alpha to reach 1027.04 +- 50.13 mu/ml and IL-6 to reach 506.89 +- 25.35 pg/ml whereas the repeated doses of S(+) ketamine decreased TNF-alpha to reach 905.64 +- 35065 mu/ml and IL-6 to reach 412.79 +- 16.5 pg/ml (P < 0.05). Ketamine 58-71 interleukin 6 Homo sapiens 128-132 26238934-4 2015 In the present study, the effects of pravastatin on fibrinogen- and FDP-induced expression of IL-6, TNF-alpha and iNOS were observed in VSMCs. Pravastatin 37-48 interleukin 6 Homo sapiens 94-98 28663607-7 2017 The study also revealed that a single preincision dose of S(+) ketamine decreased TNF-alpha to reach 1027.04 +- 50.13 mu/ml and IL-6 to reach 506.89 +- 25.35 pg/ml whereas the repeated doses of S(+) ketamine decreased TNF-alpha to reach 905.64 +- 35065 mu/ml and IL-6 to reach 412.79 +- 16.5 pg/ml (P < 0.05). Ketamine 58-71 interleukin 6 Homo sapiens 263-267 32185252-7 2017 Results: Celecoxib led to decrease of both synovial fluid and serum levels of IL-6 (p=0.017 and p=0.003, respectively). Celecoxib 9-18 interleukin 6 Homo sapiens 78-82 32185252-8 2017 In the etoricoxib treated group synovial fluid IL-6 concentration was significantly decreased after treatment (p=0.019). Etoricoxib 7-17 interleukin 6 Homo sapiens 47-51 29235333-10 2016 The polyphenol also potentiated replenishing of intracellular IL-6 and IL-10 concentrations and their secretion into incubation medium. Polyphenols 4-14 interleukin 6 Homo sapiens 62-66 27136576-7 2016 The expression of osteopontin, sclerostin, TNFalpha and IL6, known stimuli for decreasing osteoblast activity, were reduced with the addition of rutin or hyperoside. Rutin 145-150 interleukin 6 Homo sapiens 56-59 26238934-5 2015 The results showed that pravastatin dose-dependently inhibited fibrinogen- and FDP-stimulated expression of IL-6, TNF-alpha and iNOS in VSMCs at the mRNA and protein level. Pravastatin 24-35 interleukin 6 Homo sapiens 108-112 26238934-7 2015 This suggests that pravastatin has the ability to relieve vascular inflammation via inhibiting the generation of IL-6, TNF-alpha and iNOS. Pravastatin 19-30 interleukin 6 Homo sapiens 113-117 26996478-0 2016 Effect of Inhaled Budesonide on Interleukin-4 and Interleukin-6 in Exhaled Breath Condensate of Asthmatic Patients. Budesonide 18-28 interleukin 6 Homo sapiens 50-63 26407865-6 2015 Noteworthy, the migration capacity of PA-MSCs of second passage was significantly improved after stimulation with FGF-2 (P < 0.02), PDGF-BB (P < 0.006), MCP-1 (P < 0.002) and IL-6 (P < 0.03), whereas only TGF-beta enhanced significantly migration process of PA-MSCs of P4 12 h after the treatment (P < 0.02). Protactinium 38-40 interleukin 6 Homo sapiens 184-188 26701099-4 2016 Strikingly, evoxine also inhibits hypercapnic suppression of interleukin-6 and the chemokine CCL2 expression in human THP-1 macrophages. EVOXINE 12-19 interleukin 6 Homo sapiens 61-74 28126596-3 2017 The results of cellular experiments confirmed that the gene expression of most inflammatory factors (IL-1, IL-6 and MCP-1) and growth factors (VEGF, PDGF and EGF) by macrophages were up-regulated to varying degrees by BCP ceramic and its degradation products. hydroxyapatite-beta tricalcium phosphate 218-221 interleukin 6 Homo sapiens 107-111 26104917-8 2015 AG490, an inhibitor of Janus kinase (JAK), abolished IL-6 protection against extracellular Ca(2+) influx, mitochondrial membrane depolarization, neuronal death, and CaN activity impairment induced by NMDA. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 0-5 interleukin 6 Homo sapiens 53-57 25891413-6 2015 RV1088 was also significantly more effective at inhibiting IL-6 and IL-8 production by monocytes and RA synovial fibroblasts compared with Humira. RV1088 0-6 interleukin 6 Homo sapiens 59-63 28089725-9 2017 BCAA stimulated the activation of the redox-sensitive transcription factor NF-kappaB, which resulted in the release of pro-inflammatory molecules, such as interleukin-6, tumor necrosis factor-alpha, intracellular adhesion molecule-1 or CD40L, and the migration of PBMCs. Amino Acids, Branched-Chain 0-4 interleukin 6 Homo sapiens 155-232 28204809-0 2017 Ketamine suppresses the substance P-induced production of IL-6 and IL-8 by human U373MG glioblastoma/astrocytoma cells. Ketamine 0-8 interleukin 6 Homo sapiens 58-62 26711891-0 2016 Analogues of boswellic acids as inhibitors of pro-inflammatory cytokines TNF-alpha and IL-6. boswellic acid 13-28 interleukin 6 Homo sapiens 87-91 26756931-8 2016 Moreover, EDSS correlated positively with the frequencies of TNF-alpha, IL-6 and IL-10 producing B cells after polyclonal stimulation. N,N'-ethylenediamine disuccinic acid 10-14 interleukin 6 Homo sapiens 72-76 25891413-7 2015 Finally, RV1088 was the only inhibitor that was effective in reducing TNF-alpha, IL-6 and IL-8 synthesis in RA synovial membrane cells with low nM IC50 s. CONCLUSIONS AND IMPLICATIONS: This study demonstrates potent anti-inflammatory effect of RV1088, highlighting that distinct signalling pathways drive TNF-alpha, IL-6 and IL-8 production in the different cell types found in RA joints. RV1088 9-15 interleukin 6 Homo sapiens 81-85 28204809-7 2017 Taken together, these observations suggest that ketamine may suppress the SP-induced activation (IL-6 and IL-8 production) of U373MG cells by inhibiting the phosphorylation of signaling molecules (namely ERK1/2, p38 MAPK and NF-kappaB), thereby exerting anti-inflammatory effects. Ketamine 48-56 interleukin 6 Homo sapiens 97-101 25891413-7 2015 Finally, RV1088 was the only inhibitor that was effective in reducing TNF-alpha, IL-6 and IL-8 synthesis in RA synovial membrane cells with low nM IC50 s. CONCLUSIONS AND IMPLICATIONS: This study demonstrates potent anti-inflammatory effect of RV1088, highlighting that distinct signalling pathways drive TNF-alpha, IL-6 and IL-8 production in the different cell types found in RA joints. RV1088 9-15 interleukin 6 Homo sapiens 316-320 26154696-0 2016 Hydrogen Sulfide Attenuates Inflammatory Hepcidin by Reducing IL-6 Secretion and Promoting SIRT1-Mediated STAT3 Deacetylation. Hydrogen Sulfide 0-16 interleukin 6 Homo sapiens 62-66 26072064-8 2015 Dual treatment of pioglitazone and eplerenone demonstrated synergistic effect on reducing ICAM-1 and IL-6 expression and alleviating NF-kappaB activation when compared with their monotherapies in TNF-alpha activated renal tubular cells. Eplerenone 35-45 interleukin 6 Homo sapiens 101-105 26072064-9 2015 PPAR-gamma antagonist, GW9662, significantly attenuated protective effect on ICAM-1, IL-6 and PPAR-gamma expression by pioglitazone, eplerenone and their combined treatment. Eplerenone 133-143 interleukin 6 Homo sapiens 85-89 26984936-4 2017 Perinatal H-I induced selective neuronal death, ventriculomegaly, elevated CNS levels of IL-6 and IL-1alpha, astrogliosis, and fewer proliferating oligodendrocyte progenitors. His-Ile 10-13 interleukin 6 Homo sapiens 89-93 26602157-3 2016 Downregulation of mRNA for IL-6, TLR-8, IL-1 beta and IL-10 was found in THP-1 cells after 4h stimulation with TNF alpha in the presence of manumycin A and downregulated TLR-8 and EGR-1 genes were observed after 8h. manumycin 140-151 interleukin 6 Homo sapiens 27-31 25954992-0 2015 Pre- or post-treatment with ethanol and ethyl pyruvate results in distinct anti-inflammatory responses of human lung epithelial cells triggered by interleukin-6. ethyl pyruvate 40-54 interleukin 6 Homo sapiens 147-160 26602157-5 2016 Furthermore, manumycin A was found to inhibit IL-1beta, IL-6, and IL-8 production in TNF alpha stimulated THP-1 cells and peripheral blood monocytes in a dose dependent manner (0.25-1 muM of manumycin A) without affecting cell viability. manumycin 13-24 interleukin 6 Homo sapiens 56-60 28062289-7 2017 However, IFCD group showed significantly higher IL-4 and IL-6 levels while TNF-alpha was significantly decreased. ifcd 9-13 interleukin 6 Homo sapiens 57-61 28192516-0 2017 Correction: Atorvastatin, Losartan and Captopril Lead to Upregulation of TGF-beta, and Downregulation of IL-6 in Coronary Artery Disease and Hypertension. Losartan 26-34 interleukin 6 Homo sapiens 105-109 26391114-10 2016 Treatment with neat PTTC slightly reduced IL-6 levels and PTTC emulsion significantly reduced IL-6 levels to 92.53 +- 12.74 pg/ml compared to basal levels (141.69 +- 8.41 pg/ml). pttc 20-24 interleukin 6 Homo sapiens 42-46 25954992-8 2015 Treatment of the A549 cells with either EtOH or EtP significantly reduced the IL-6-induced release of IL-8. ethyl pyruvate 48-51 interleukin 6 Homo sapiens 78-82 25954992-10 2015 Similar data was revealed regarding the IL-6-induced neutrophil adhesion to the treated A549 cells, in which pre- and post-treatment with EtOH or EtP decreased the adhesion capacity, however, the results were dependent on the duration of incubation. ethyl pyruvate 146-149 interleukin 6 Homo sapiens 40-44 28187727-11 2017 We also found that ATO combined with CT reversed the upregulated expression of phosphorylated-STAT3Tyr705 stimulated by interleukin-6 and downregulated STAT3 direct target genes and the anti-apoptotic proteins Bcl-2, XIAP, and survivin but obviously upregulated the promoting apoptosis proteins Bak,.In vivo studies showed that ATO combined with CT decreased tumor growth. cryptotanshinone 37-39 interleukin 6 Homo sapiens 120-133 25833826-9 2015 Plasma concentrations of interleukin-6, other biomarkers of inflammation, and markers of oxidative damage to proteins and lipids were elevated, particularly in patients with sepsis, and were inversely related to plasma zinc and selenium concentrations. Selenium 228-236 interleukin 6 Homo sapiens 25-38 28178994-11 2017 RESULTS: Doxycycline decreased plasma lysophosphatidate concentrations, delayed tumor growth and decreased the concentrations of several cytokines/chemokines (IL-1beta, IL-6, IL-9, CCL2, CCL11, CXCL1, CXCL2, CXCL9, G-CSF, LIF, VEGF) in the tumor. Doxycycline 9-20 interleukin 6 Homo sapiens 169-173 27802778-7 2017 Transplantation of these cells significantly decreased OVX-induced serum levels of interleukin 6 and interleukin 1 beta, and receptor activator of nuclear factor kappa B gene expression levels in bone tissue. ovx 55-58 interleukin 6 Homo sapiens 83-96 27190500-3 2016 The supernatant culture medium of the TPC-1 cells that was treated either with 15d-PGJ2 or with vehicle (control) for 24 hours was assessed for IL-6 secretion via CBA assay. 15-deoxy-delta(12,14)-prostaglandin J2 79-87 interleukin 6 Homo sapiens 144-148 27190500-5 2016 TPC-1 cells treated with 15d-PGJ2 decreased the secretion and expression of IL-6 and STAT3, while it increased SOCS1 and SOCS3. 15-deoxy-delta(12,14)-prostaglandin J2 25-33 interleukin 6 Homo sapiens 76-80 27190500-6 2016 Overall, we demonstrated that 15d-PGJ2 downregulated IL-6 signaling pathway and led TPC-1 cells into apoptosis. 15-deoxy-delta(12,14)-prostaglandin J2 30-38 interleukin 6 Homo sapiens 53-57 26396259-11 2015 Moreover, cytosporone B, an NR4A1 agonist, completely reversed cholesterol-induced IL-6 (interleukin 6) and MCP-1 (monocyte chemoattractant protein 1) expression to below basal levels, and knockdown of NR4A1 expression by siRNA not only mimicked, but also exaggerated the effects of cholesterol on inflammatory biomarker up-regulation. cytosporone B 10-23 interleukin 6 Homo sapiens 83-87 26396259-11 2015 Moreover, cytosporone B, an NR4A1 agonist, completely reversed cholesterol-induced IL-6 (interleukin 6) and MCP-1 (monocyte chemoattractant protein 1) expression to below basal levels, and knockdown of NR4A1 expression by siRNA not only mimicked, but also exaggerated the effects of cholesterol on inflammatory biomarker up-regulation. cytosporone B 10-23 interleukin 6 Homo sapiens 89-102 26166660-11 2015 CONCLUSIONS: These results suggest that apigenin may inhibit IS-induced ER stress and expression of IL-6 and p21 proteins in HK-2 cells. Indican 61-63 interleukin 6 Homo sapiens 100-104 26869278-3 2017 METHODS: Human mesothelial cells (Met-5A) were incubated with different concentrations of glucose and mannitol, and the effect of glucose and mannitol on the expression of IL-6 was determined. Mannitol 142-150 interleukin 6 Homo sapiens 172-176 26869278-8 2017 High glucose and mannitol could upregulate IL-6 mRNA expression and IL-6 secretion in mesothelial cells significantly, and there was no difference of its effect between high glucose and mannitol. Mannitol 17-25 interleukin 6 Homo sapiens 43-47 26520687-9 2015 It was also demonstrated that T2DM patients with higher median of urinary 8-OHdG had significantly elevated levels of IL-6, TNF-alpha and HOMA-IR, and decreased IL-10 levels. 8-ohdg 74-80 interleukin 6 Homo sapiens 118-122 25836975-9 2015 IL6 secretion in response to EPS was significantly reduced in CFS compared with control cultures at all time points measured. eps 29-32 interleukin 6 Homo sapiens 0-3 26402162-4 2015 We evaluated the effect of sodium selenite on IL6-induced disruption on deiodinase function. Sodium Selenite 27-42 interleukin 6 Homo sapiens 46-49 26402162-12 2015 In conclusion, although sodium selenite reduces IL6-induced redox imbalance it does not fully repair deiodinase function. Sodium Selenite 24-39 interleukin 6 Homo sapiens 48-51 26869278-8 2017 High glucose and mannitol could upregulate IL-6 mRNA expression and IL-6 secretion in mesothelial cells significantly, and there was no difference of its effect between high glucose and mannitol. Mannitol 17-25 interleukin 6 Homo sapiens 68-72 27321203-9 2017 The TA IL-6 was positively correlated with 8-OHdG levels on the 1st day (r = 0.64, p < 0.05) and 28th day of life (r = 0.76, p < 0.05). 8-ohdg 43-49 interleukin 6 Homo sapiens 7-11 25081498-8 2015 Serum IL-6 levels in G carries (CG + GG) (195.1 +- 11.8 pg/ml) elevated significantly compared to CC homozygotes (167.7 +- 6.7 pg/ml) in EV71-infected patients (p<0.001), but no significant differences were observed in CSF IL-6 levels among different genotypes in patients with EV71 encephalitis. cysteinylglycine 32-34 interleukin 6 Homo sapiens 6-10 28247848-7 2017 Sildenafil administration to patients with elevated pulmonary vascular resistance resulted in improvement of pulmonary blood flow (p = 0.012) and systemic oxygen saturation (p = 0.010), with a decrease in serum interleukin 6 (p = 0.027) and soluble ICAM-1 (p = 0.011). Sildenafil Citrate 0-10 interleukin 6 Homo sapiens 211-224 26555695-8 2015 One such peptide, PN-2921, contained a 40 kDa polyethylene glycol (PEG) moiety and inhibited IL-6-induced pSTAT3 in U937 cells with sub-nM potency and possessed 23, 36, and 59 h PK half-life values in mice, rats, and cynomolgus monkeys, respectively. Peptides 9-16 interleukin 6 Homo sapiens 93-97 26555695-8 2015 One such peptide, PN-2921, contained a 40 kDa polyethylene glycol (PEG) moiety and inhibited IL-6-induced pSTAT3 in U937 cells with sub-nM potency and possessed 23, 36, and 59 h PK half-life values in mice, rats, and cynomolgus monkeys, respectively. PN-2921 18-25 interleukin 6 Homo sapiens 93-97 29204439-8 2017 Further investigation is needed to define the role of IL-6 in TH1/TH2/TH17-regulated signaling pathway in ketamine-induced cystitis. Ketamine 106-114 interleukin 6 Homo sapiens 54-58 26222339-6 2015 In patients with CD, VAT/FM ratio was associated with leptin (P = 0.009) and interleukin 6 (P = 0.032) concentrations, and higher in short-term than in long-term remission (72.6 +- 27.1 mL/kg versus 54.8 +- 16.1 mL/kg, P = 0.079). Fermium 25-27 interleukin 6 Homo sapiens 77-90 25673294-7 2015 We then showed that PLB-Ect down-regulated NiSO4-induced moDC maturation, as witnessed by decreased expression of CD40, CD80, CD83, CD86, PDL-1, and HLA-DR and by decreased levels of IL-1beta, IL-6, TNF-alpha, and IL-12p40 mRNAs. nickel sulfate 43-48 interleukin 6 Homo sapiens 193-197 26556688-4 2015 RESULTS: IL-6 variants rs2066992 and rs10242595 were nominally associated with response to duloxetine (p = 0.047 and p = 0.028, respectively). Duloxetine Hydrochloride 91-101 interleukin 6 Homo sapiens 9-13 29683134-5 2017 DHA administration resulted in approximately a doubling of plasma and red cell phospholipid and adipose tissue DHA content but no change in systemic markers of inflammation, such as circulating C-reactive protein (CRP) or interleukins (IL) 6, 8 and 10 (IL-6, IL-8, IL-10). Docosahexaenoic Acids 0-3 interleukin 6 Homo sapiens 253-257 25861245-0 2015 TNF-alpha and IL-6 inhibit apolipoprotein A-IV production induced by linoleic acid in human intestinal Caco2 cells. caco2 103-108 interleukin 6 Homo sapiens 14-18 27541080-9 2017 Pharmacologic inhibition of AT1R through losartan modulated mRNA transcription of IL-6 and IL-8 in HPLF but not in HGF. Losartan 41-49 interleukin 6 Homo sapiens 82-86 26556688-7 2015 CONCLUSION: Our findings tentatively suggest that IL-6 variants play a role in duloxetine and placebo response, which warrants further investigation. Duloxetine Hydrochloride 79-89 interleukin 6 Homo sapiens 50-54 26472156-5 2015 Ex vivo, Gamma secretase inhibitor (GSI) (inhibitor of Notch receptor processing) significantly diminished the PGN+poly(I:C)-induced secretion of M1- and M2-associated cytokines in decidual macrophages, and of proinflammatory cytokines (IFN-gamma, TNF-alpha and IL-6) and chemokines (MIP-1beta) in decidual and placental cells. 2-(5-Chlorothiophen-2-Yl)-N-[(3s)-1-(4-{2-[(Dimethylamino)methyl]-1h-Imidazol-1-Yl}-2-Fluorophenyl)-2-Oxopyrrolidin-3-Yl]ethanesulfonamide 36-39 interleukin 6 Homo sapiens 262-266 27541080-11 2017 CONCLUSION: These results suggest that AT1R knockdown and AT1R pharmacologic blockade by losartan may differently control balance of inflammatory cytokines, such as IL-6 and IL-8, in primary human periodontal fibroblasts. Losartan 89-97 interleukin 6 Homo sapiens 165-169 25763062-2 2014 A strong over expression of IL-6, IL-8, IFNalpha and IFNgamma was observed in bursa at 3 days post inoculation together with an increase in splenic NO2 release. Nitrogen Dioxide 148-151 interleukin 6 Homo sapiens 28-32 27718369-7 2017 Ketamine significantly increased IL-6 levels and significantly decreased sTNFR1 levels. Ketamine 0-8 interleukin 6 Homo sapiens 33-37 28033321-10 2016 DISCUSSION: According to the results it seems that Atorvastatin, Losartan and Captopril have reduced inflammation in in vivo conditions via downregulation of IL-6 and upregulation of TGF-beta. Losartan 65-73 interleukin 6 Homo sapiens 158-162 26468083-7 2015 RESULTS: We found that Everolimus significantly inhibited the differentiation of OCs and their in vitro bone-resorbing activity, and also found decreases of both mRNA and secreted pro-OC factors such as M-CSF, IL-6, and IL-1beta, whose lower ELISA levels paralleled the defective phosphorylation of NFkB pathway effectors. Everolimus 23-33 interleukin 6 Homo sapiens 210-214 26202107-6 2015 Norethisterone oenanthate users had significantly higher IL-6, IL-8, and RANTES concentrations. norethindrone enanthate 0-25 interleukin 6 Homo sapiens 57-61 25665607-17 2015 CONCLUSIONS: LMWH, which was given early in sepsis, can significantly down-regulate the expression of CD62p, D-dimmer, IL-6 and TNF-alpha, and reduce the incidence of MODS. Heparin, Low-Molecular-Weight 13-17 interleukin 6 Homo sapiens 119-123 26378384-5 2015 Ammonia correlated positively with IL-1 and IL-6. Ammonia 0-7 interleukin 6 Homo sapiens 44-48 26340264-7 2015 The adipose tissue and placenta of treated women exhibited a significant decrease in TLR4 adipose and placental expression as well as IL6, IL8, and TNFalpha In vitro, EPA and DHA suppressed the activation of TLR4, IL6, IL8 induced by palmitate in culture of adipose and trophoblast cells. Docosahexaenoic Acids 175-178 interleukin 6 Homo sapiens 134-137 26340264-7 2015 The adipose tissue and placenta of treated women exhibited a significant decrease in TLR4 adipose and placental expression as well as IL6, IL8, and TNFalpha In vitro, EPA and DHA suppressed the activation of TLR4, IL6, IL8 induced by palmitate in culture of adipose and trophoblast cells. Docosahexaenoic Acids 175-178 interleukin 6 Homo sapiens 214-217 26252649-11 2015 UC groups were compared and women treated with azathioprine showed reduction of total protein, globulin, ESR, and lymphocytes, with increased IL-6, TNF, IL-10, and TGF-beta. Azathioprine 47-59 interleukin 6 Homo sapiens 142-146 27733566-8 2016 WMH accounted for 30% attenuation in the relationship between higher sustained IL-6 levels and slower gait speed (p = 0.043) in the mediation analyses. 1-methyl-1H-1,2,3-triazole 0-3 interleukin 6 Homo sapiens 79-83 28670189-3 2016 The aim of our study was to investigate, through assessment of plasma ACTH, serum IL-6, and salivary/serum cortisol levels, if chronic magnesium supplementation might reduce damaging stress effects in amateur rugby players. Magnesium 135-144 interleukin 6 Homo sapiens 82-86 28670189-9 2016 Our results revealed that magnesium completely abolished the increase in IL-6 level noted in control group on Day1 and Day3 vs. Day-1 (p < 0.01) and also diminished the rise in neutrophil/lymphocyte ratio in intervention group vs. control group (p < 0.01). Magnesium 26-35 interleukin 6 Homo sapiens 73-77 26609631-4 2016 Here, we show that benzo[a]pyrene diol epoxide (BPDE, the active metabolite of cigarette smoke carcinogen benzo[a]pyrene)-induced human bronchial epithelial cell (HBEC) transformation was enhanced by IL-6 in vitro. Benzo(a)pyrene 19-33 interleukin 6 Homo sapiens 200-204 27488030-0 2016 Reactive Oxygen Stimulation of Interleukin-6 Release in the Human Trophoblast Cell Line HTR-8/SVneo by the Trichlorethylene Metabolite S-(1,2-Dichloro)-l-Cysteine. Trichloroethylene 107-123 interleukin 6 Homo sapiens 31-44 26652682-5 2015 We found that K2EDTA mean plasma concentrations of both IL-6 and CRP were not significantly different from concentrations in plasma processed immediately; this was observed for tubes stored up to 48 hours pre-processing at either temperature. k2edta 14-20 interleukin 6 Homo sapiens 56-60 27488030-7 2016 Moreover, 10 and 20 muM DCVC increased mRNA expression and release of interleukin-6 (IL-6) after 24-h exposure, and these responses were inhibited by the cysteine conjugate beta-lyase inhibitor aminooxyacetic acid and by treatments with antioxidants (alpha-tocopherol and deferoxamine), suggesting that DCVC-stimulated IL-6 release in HTR-8/SVneo cells is dependent on beta-lyase metabolic activation and increased generation of ROS. S-(1,2-dichlorovinyl)cysteine 24-28 interleukin 6 Homo sapiens 70-83 27488030-7 2016 Moreover, 10 and 20 muM DCVC increased mRNA expression and release of interleukin-6 (IL-6) after 24-h exposure, and these responses were inhibited by the cysteine conjugate beta-lyase inhibitor aminooxyacetic acid and by treatments with antioxidants (alpha-tocopherol and deferoxamine), suggesting that DCVC-stimulated IL-6 release in HTR-8/SVneo cells is dependent on beta-lyase metabolic activation and increased generation of ROS. S-(1,2-dichlorovinyl)cysteine 24-28 interleukin 6 Homo sapiens 85-89 27488030-7 2016 Moreover, 10 and 20 muM DCVC increased mRNA expression and release of interleukin-6 (IL-6) after 24-h exposure, and these responses were inhibited by the cysteine conjugate beta-lyase inhibitor aminooxyacetic acid and by treatments with antioxidants (alpha-tocopherol and deferoxamine), suggesting that DCVC-stimulated IL-6 release in HTR-8/SVneo cells is dependent on beta-lyase metabolic activation and increased generation of ROS. S-(1,2-dichlorovinyl)cysteine 24-28 interleukin 6 Homo sapiens 319-323 27488030-7 2016 Moreover, 10 and 20 muM DCVC increased mRNA expression and release of interleukin-6 (IL-6) after 24-h exposure, and these responses were inhibited by the cysteine conjugate beta-lyase inhibitor aminooxyacetic acid and by treatments with antioxidants (alpha-tocopherol and deferoxamine), suggesting that DCVC-stimulated IL-6 release in HTR-8/SVneo cells is dependent on beta-lyase metabolic activation and increased generation of ROS. Deferoxamine 272-284 interleukin 6 Homo sapiens 85-89 27488030-7 2016 Moreover, 10 and 20 muM DCVC increased mRNA expression and release of interleukin-6 (IL-6) after 24-h exposure, and these responses were inhibited by the cysteine conjugate beta-lyase inhibitor aminooxyacetic acid and by treatments with antioxidants (alpha-tocopherol and deferoxamine), suggesting that DCVC-stimulated IL-6 release in HTR-8/SVneo cells is dependent on beta-lyase metabolic activation and increased generation of ROS. S-(1,2-dichlorovinyl)cysteine 303-307 interleukin 6 Homo sapiens 85-89 27488030-9 2016 The present study demonstrates that DCVC stimulated ROS generation in the human placental cell line HTR-8/SVneo and provides new evidence of mechanistic linkage between DCVC-stimulated ROS and increase in proinflammatory cytokine IL-6. S-(1,2-dichlorovinyl)cysteine 36-40 interleukin 6 Homo sapiens 230-234 24764451-7 2015 RN486 significantly inhibited macrophage IL-6 production induced by Fc receptor and CD40 ligation. RN486 0-5 interleukin 6 Homo sapiens 41-45 25801692-6 2015 However, overall significant decreases in MCP-1, PAI-1, MMP-9, IL-18 and IL-6, and increases in adropin and osteocrin plasma concentrations occurred after T&A. t& 155-160 interleukin 6 Homo sapiens 73-77 27488030-9 2016 The present study demonstrates that DCVC stimulated ROS generation in the human placental cell line HTR-8/SVneo and provides new evidence of mechanistic linkage between DCVC-stimulated ROS and increase in proinflammatory cytokine IL-6. S-(1,2-dichlorovinyl)cysteine 169-173 interleukin 6 Homo sapiens 230-234 27145783-4 2016 AOPP-FR and AOPP-HOCl were able to induce the activation of the gene transcription of NF-kappaB, COX-2, and IL-6 in HEK 293 cells. aopp-fr 0-7 interleukin 6 Homo sapiens 108-112 27145783-6 2016 AOPP-FR induces the activation of the gene transcription of NF-kappaB, COX-2, and IL-6 and may represent a novel pathogenic mediator of inflammation in kidney. aopp-fr 0-7 interleukin 6 Homo sapiens 82-86 25864742-0 2015 Effect of trimetazidine on serum interleukin-6 and C-reactive protein concentrations in patients with stable coronary artery disease. Trimetazidine 10-23 interleukin 6 Homo sapiens 33-46 27272805-6 2016 C-reactive protein (CRP) and interleukin-6 (IL-6) correlated with each other and exhibited positive correlation with age, body-mass index (BMI), leukocyte count, platelet count, kynurenine, kynurenine/tryptophan ratio and urinary neopterin and a negative correlation with vitamin D and retinol. Neopterin 230-239 interleukin 6 Homo sapiens 29-42 27272805-6 2016 C-reactive protein (CRP) and interleukin-6 (IL-6) correlated with each other and exhibited positive correlation with age, body-mass index (BMI), leukocyte count, platelet count, kynurenine, kynurenine/tryptophan ratio and urinary neopterin and a negative correlation with vitamin D and retinol. Neopterin 230-239 interleukin 6 Homo sapiens 44-48 25852008-7 2015 The intracellular calcium chelator BAPTA-AM blunted l-C16 carnitine-mediated IL-6 production by >65%. -c16 carnitine 53-67 interleukin 6 Homo sapiens 77-81 25864742-10 2015 Three-month trimetazidine treatment increased IL-6 concentrations (1.64 vs 2.23 pg/mL, p < 0.05). Trimetazidine 12-25 interleukin 6 Homo sapiens 46-50 25910532-2 2015 The aim of this study was to determine whether the addition of ketamine reduces remifentanil-induced hyperalgesia; improves its analgesic effect; and alters interleukin 6 (IL-6), IL-8, and IL-10 levels. Ketamine 63-71 interleukin 6 Homo sapiens 157-170 26687339-9 2016 RESULTS: The combination of ezetimibe plus rosuvastatin decreased total cholesterol, low-density lipoprotein cholesterol, hsCRP, IL-6, and MMP-9 levels at six and 12 months after treatment. Ezetimibe 28-37 interleukin 6 Homo sapiens 129-133 25864742-14 2015 Moreover, it resulted in the reduction of CRP concentration The increase of IL-6 concentration after three-month trimetazidine treatment and the lack of changes of its concentration after TET is associated with yet another mechanism of trimetazidine. Trimetazidine 113-126 interleukin 6 Homo sapiens 76-80 25910532-2 2015 The aim of this study was to determine whether the addition of ketamine reduces remifentanil-induced hyperalgesia; improves its analgesic effect; and alters interleukin 6 (IL-6), IL-8, and IL-10 levels. Ketamine 63-71 interleukin 6 Homo sapiens 172-176 25864742-14 2015 Moreover, it resulted in the reduction of CRP concentration The increase of IL-6 concentration after three-month trimetazidine treatment and the lack of changes of its concentration after TET is associated with yet another mechanism of trimetazidine. Trimetazidine 236-249 interleukin 6 Homo sapiens 76-80 26204360-10 2015 RESULTS: Histology, serum IL-6, and ALT release revealed that HADMSC treatment attenuated liver injury compared with control animals. hadmsc 62-68 interleukin 6 Homo sapiens 26-30 25903726-5 2015 Ketamine suppressed the production of the only established depression-relevant proinflammatory cytokines, IL-6 and TNFalpha. Ketamine 0-8 interleukin 6 Homo sapiens 106-123 24862236-4 2015 The present study has evaluated the effect of 1 microM arsenite [As(III)], 0.1 microM MMA(III) and 1 microM DMA(III) upon the release of cytokines [interleukin-6 (IL6), IL8, tumor necrosis factor alpha (TNFalpha)], using a compartmentalized co-culture model with differentiated Caco-2 cells in the apical compartment and peripheral blood mononuclear cells in the basolateral compartment. N-myristoyl-alaninol 108-111 interleukin 6 Homo sapiens 148-161 26963242-0 2016 Benzo(a)pyrene induces interleukin (IL)-6 production and reduces lipid synthesis in human SZ95 sebocytes via the aryl hydrocarbon receptor signaling pathway. Benzo(a)pyrene 0-14 interleukin 6 Homo sapiens 23-41 25653478-6 2015 We found that THC suppressed the release of proinflammatory factors, including tumor necrosis factor alpha (TNF-alpha), interleukin- (IL-) 1beta, IL-6, and IL-8, decreased nuclear factor-kappaB (NF-kappaB) expression, and inhibited the upregulation of cofilin-1 protein in the LPS-stimulated MG-63 cells. Dronabinol 14-17 interleukin 6 Homo sapiens 146-150 26467187-7 2016 Cannabinoid receptor activation by the specific synthetic agonists ACEA and JWH-133 (but not the endogenous agonist 2-arachidonoylglycerol) markedly inhibits LPS-induced production of vascular endothelial growth factor-A, vascular endothelial growth factor-C, and angiopoietins and modestly affects IL-6 secretion. arachidonyl-2-chloroethylamide 67-71 interleukin 6 Homo sapiens 299-303 25647267-10 2015 While Y-27632 alone lowered IL-6 level, it increased leptin and TNF-alpha concentration without altering resistin and adiponectin. Y 27632 6-13 interleukin 6 Homo sapiens 28-32 26150866-0 2015 Effects of Ringer"s sodium pyruvate solution on serum tumor necrosis factor-alpha and interleukin-6 upon septic shock. SODIUM PYRUVATE 20-35 interleukin 6 Homo sapiens 86-99 25203937-6 2015 IL-6, IFNgamma, and IL-17A levels were significantly reduced after methylprednisolone treatment (p = 0.02, 0.03, and 0.03, respectively) in Severe Persistent Asthma (SPA) and in Moderate Persistent Asthma (MPA), (p = 0.007, 0.01, and 0.007, respectively). Methylprednisolone 67-85 interleukin 6 Homo sapiens 0-4 26947457-5 2016 The new compound murrayakonine A (), O-methylmurrayamine A () and murrayanine () were proven to be the most active, efficiently inhibiting TNF-alpha and IL-6 release in a dose-dependent manner and showing decreased LPS induced TNF-alpha and IL-6 production in human PBMCs [corrected]. Murrayakonine A 17-32 interleukin 6 Homo sapiens 153-157 26947457-5 2016 The new compound murrayakonine A (), O-methylmurrayamine A () and murrayanine () were proven to be the most active, efficiently inhibiting TNF-alpha and IL-6 release in a dose-dependent manner and showing decreased LPS induced TNF-alpha and IL-6 production in human PBMCs [corrected]. Murrayakonine A 17-32 interleukin 6 Homo sapiens 241-245 25203937-8 2015 CONCLUSION: Methylprednisolone downregulated IL-6, IL17A, and IFNgamma, but not IL-22, in stimulated PBMCs from asthmatic children indicating that methylprednisolone has no effect on IL-22 production by PBMCs. Methylprednisolone 12-30 interleukin 6 Homo sapiens 45-49 26150866-1 2015 OBJECTIVE: To study the effects of Ringer"s sodium pyruvate solution on tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) upon septic shock. SODIUM PYRUVATE 44-59 interleukin 6 Homo sapiens 116-129 26319019-4 2016 Our observations showed that pretreatment with PQQ significantly inhibited the expression of matrix metalloproteinase (MMP)-1 and MMP-3 and suppressed the production of proinflammatory mediators such as TNF-alpha and IL-6 in IL-1beta-treated SW982 cells. PQQ Cofactor 47-50 interleukin 6 Homo sapiens 217-221 26150866-1 2015 OBJECTIVE: To study the effects of Ringer"s sodium pyruvate solution on tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) upon septic shock. SODIUM PYRUVATE 44-59 interleukin 6 Homo sapiens 131-135 25463072-9 2014 Blocking experiments with IL-1-receptor antagonist showed that IL-1 decisively contributed to the 25-hydroxycholesterol-induced synergistic IL-6 and MCP-1 production. Hydroxycholesterols 101-119 interleukin 6 Homo sapiens 140-144 26518637-5 2016 Moreover, an allele of IL6 rs2961298 was associated with higher cg01770232 methylation (p = 2.55 x 10(-7) ). cg01770232 64-74 interleukin 6 Homo sapiens 23-26 25976322-7 2016 CTQ+ patients also exhibited increased baseline expression of gene transcripts related to inflammatory signaling, and baseline inflammatory markers including c-reactive protein, interleukin (IL)-6, and IL-1 receptor antagonist were positively correlated with depression, fatigue, and stress scores in CTQ+ but not CTQ- patients. ctq+ 0-4 interleukin 6 Homo sapiens 178-196 27063305-0 2016 [The effect of calcium hydroxide on IL-6 and TNF-alpha expression of osteoblast in periapical tissues]. Calcium Hydroxide 15-32 interleukin 6 Homo sapiens 36-40 25277671-11 2015 Finally, Sildenafil administration significantly reduced serum levels of interleukin 6 (IL6, -0.82 pg/ml; 95% CI -1.58 to -0.07). Sildenafil Citrate 9-19 interleukin 6 Homo sapiens 73-86 25277671-11 2015 Finally, Sildenafil administration significantly reduced serum levels of interleukin 6 (IL6, -0.82 pg/ml; 95% CI -1.58 to -0.07). Sildenafil Citrate 9-19 interleukin 6 Homo sapiens 88-91 25277671-13 2015 Chronic Sildenafil administration seems to improve hemodynamic (FMD) and serum pro-inflammatory makers (IL6) in diabetic men. Sildenafil Citrate 8-18 interleukin 6 Homo sapiens 104-107 24130267-2 2015 Activation of kainate (KA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors (GluRs) increase interleukin-6 (IL-6) release and cause arthritic pain, respectively. Kainic Acid 14-21 interleukin 6 Homo sapiens 132-145 24130267-2 2015 Activation of kainate (KA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors (GluRs) increase interleukin-6 (IL-6) release and cause arthritic pain, respectively. Kainic Acid 14-21 interleukin 6 Homo sapiens 147-151 27063305-6 2016 CONCLUSIONS: Calcium hydroxide placed in different position of the root canal could increase periapical pH value and reduce IL- 6, TNF-alpha expression of periapical osteoblasts. Calcium Hydroxide 13-30 interleukin 6 Homo sapiens 124-129 25218635-3 2014 Simplexin, a daphnane diterpene ester, was identified for the first time from this genus and caused an increase in the production of cytokines (IFNgamma, IL1beta, IL6, and IL13) by peripheral blood mononuclear cells. diterpene ester 22-37 interleukin 6 Homo sapiens 163-166 25273676-14 2014 Ki16425, another LPA1 antagonist, also suppressed IL-6 production by LPA-stimulated RA FLSs. 3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid 0-7 interleukin 6 Homo sapiens 50-54 26873192-6 2016 We also observed that ATS inhibited IL-6 driven STAT-3-DNA binding activity with comparable potency to S3I-201 in a cell free system. Artesunate 22-25 interleukin 6 Homo sapiens 36-40 25977597-3 2015 In this study, we wanted to assess the efficacy of both low and high doxycycline doses in modulating IL-8, TNF-alpha, and IL-6 gene expression in HaCaT cells stimulated with LPS. Doxycycline 69-80 interleukin 6 Homo sapiens 122-126 25092526-8 2014 RESULTS: Mannan, beta-glucans (curdlan), chitosan, and zymosan induced the secretion of interleukin (IL)-1beta, IL-6, IL-23, IL-10, and tumor necrosis factor-alpha by PBMCs. beta-Glucans 17-29 interleukin 6 Homo sapiens 112-116 25275309-3 2014 Exposure of cells to sphingosine 1-phosphate induced pro-inflammatory responses characterized by interleukin-6, interleukin-8, and cyclooxygenase-2 up-regulations, as observed by ELISA and Western blot. sphingosine 1-phosphate 21-44 interleukin 6 Homo sapiens 97-110 25407340-9 2014 RESULTS: In peripheral blood mononuclear cells (PBMCs) derived from GOS-treated foals at day 28, a standardized lipopolysaccharide challenge resulted in significantly lower relative mRNA expression levels of the pro-inflammatory cytokines interferon-gamma and interleukin-6 compared with PBMCs of control foals. D-Glucitol-1,6-bisphosphate 68-71 interleukin 6 Homo sapiens 260-273 25522414-8 2014 Unexpectedly, sertraline and DHA had pro-inflammatory effects, with sertraline increasing IFN-alpha and IL-6 and DHA increasing IL-15, IL-1RA, IFN-alpha, and IL-6, though these changes were also associated with a decrease in NF-kB activity, suggesting distinct modes of action. Docosahexaenoic Acids 29-32 interleukin 6 Homo sapiens 158-162 26270575-6 2015 RESULTS: DHA significantly attenuated IL-1beta induced proinflammatory IL-8 and IL-6 protein and mRNA in fetal H4, NEC-IEC, and mature Caco2, NCM460 IEC, compared to control and PAL treatment. Docosahexaenoic Acids 9-12 interleukin 6 Homo sapiens 80-84 25587326-7 2014 In addition, LCE also decreased the TNF-alpha, IL-1beta and IL-6 levels in UVB-irradiated HaCaT cells. LCE 13-16 interleukin 6 Homo sapiens 60-64 26541096-7 2015 Additionally, butyrate and propionate inhibited the expression of lipopolysaccharide (LPS)-induced cytokines such as IL-6 and IL-12p40 showing a strong anti-inflammatory effect. Propionates 27-37 interleukin 6 Homo sapiens 117-121 26407654-9 2015 Regarding inflammatory parameters, barnidipine reduced TNF-a, IL-6, and Hs-CRP, both in monotherapy, and after simvastatin addition. mepirodipine 35-46 interleukin 6 Homo sapiens 62-66 24803294-0 2014 Andrographolide suppresses IL-6/Stat3 signaling in peripheral blood mononuclear cells from patients with chronic rhinosinusitis with nasal polyps. andrographolide 0-15 interleukin 6 Homo sapiens 27-31 24803294-6 2014 Andrographolide significantly inhibited IL-6 and IL-17 production, suppressed p-Stat3 expression, and inhibited Th17 differentiation of PBMCs in vitro. andrographolide 0-15 interleukin 6 Homo sapiens 40-44 24274595-5 2014 Compared with macrophages from healthy subjects, CCPA macrophages showed unrestrained rises in IL1A, IL1B, IL6, IRAK2 and TRAF6 throughout the experiment, and a lack of expression of TGFB1 at 9 h. Single nucleotide polymorphisms (SNPs) associated with CCPA were found in IL1B (n = 2), IL1RN and IL15 (n = 3). 2-chloro-N(6)cyclopentyladenosine 49-53 interleukin 6 Homo sapiens 107-110 25029008-7 2014 In the acute phase, DHA significantly reduced the serum CK (12.5%) and the IL-6 response (32%) but did not affect STR or DOMS. Docosahexaenoic Acids 20-23 interleukin 6 Homo sapiens 75-79 24811262-8 2014 Flavopiridol NPs significantly decreased inflammatory factor synthesis by astrocytes, including TNF-alpha, IL-1beta, and IL-6, while the IL-10 expression was elevated. alvocidib 0-12 interleukin 6 Homo sapiens 121-125 26472417-9 2015 Patients in Boolean and SDAI remissions had significantly higher serum ICTP, resistin, and IL-6 levels in comparison with the controls. sdai 24-28 interleukin 6 Homo sapiens 91-95 26376676-0 2015 A novel anti-cancer agent Icaritin suppresses hepatocellular carcinoma initiation and malignant growth through the IL-6/Jak2/Stat3 pathway. icaritin 26-34 interleukin 6 Homo sapiens 115-119 26376676-5 2015 We also found that Icaritin reduced expression of Interleukin-6 Receptors (IL-6Rs), attenuated both constitutive and IL-6-induced phosphorylation of Janus-activated kinases 2 (Jak2) and Signal transducer and activator of transcription 3 (Stat3), and inhibited Stat3 downstream genes, such as Bmi-1 and Oct4. icaritin 19-27 interleukin 6 Homo sapiens 75-79 24742998-4 2014 METHODS AND RESULTS: We showed that VPA inhibited the production of IFN-alpha and the proinflammatory cytokines TNF-alpha and IL-6 by CpG-activated PDC. Valproic Acid 36-39 interleukin 6 Homo sapiens 126-130 25781052-9 2015 After MAG-DHA treatments, messenger RNA transcript levels for MUC5AC, IL-6, and IL-8 were markedly reduced in LPS-treated CFTR siRNA bronchi. docosahexaenoic acid monoacylglyceride 6-13 interleukin 6 Homo sapiens 70-74 24831018-10 2014 RESULTS: Both H2S sources led to significant reductions in NO, PGE-2, IL6 and MMP13 released by the cells and at the protein level. Hydrogen Sulfide 14-17 interleukin 6 Homo sapiens 70-73 24803181-5 2014 Nevertheless, there is a large body of data which indicates that under certain experimental conditions lithium also exhibits pro-inflammatory properties (e.g., induction of IL-4, IL-6 and other pro-inflammatory cytokines synthesis). Lithium 103-110 interleukin 6 Homo sapiens 179-183 26465888-11 2015 The expression levels of IL-6 and IL-8 were reduced when cells were seeded on graphene foam as compared to Ti and graphene film. Graphite 78-86 interleukin 6 Homo sapiens 25-29 26465888-11 2015 The expression levels of IL-6 and IL-8 were reduced when cells were seeded on graphene foam as compared to Ti and graphene film. Graphite 114-122 interleukin 6 Homo sapiens 25-29 25429809-11 2014 After CPFA was performed for the first time, the plasma levels of TNF-alpha, IL-1beta, and IL-6 from site D were significantly lower than those from site C before CPFA was performed for the first time (with t values respectively 5.48, 2. cpfa 6-10 interleukin 6 Homo sapiens 91-95 25958167-7 2015 Bates-Jensen wound assessment tool severity scorings, proinflammatory cytokines (tumor necrosis factor-alpha, interleukin 1beta, and interleukin 6), and matrix metalloproteinase-8 were significantly decreased in response to CTI. titanium carbide 224-227 interleukin 6 Homo sapiens 133-146 25174381-18 2014 Compared with those detected before treatment, the levels of TNF-alpha, IL-6, and IL-8 in serum of group BP at PTH 24 and 48 were significantly decreased (with P values below 0.01). Benzo(a)pyrene 105-107 interleukin 6 Homo sapiens 72-76 24405885-7 2014 The levels of PGE2 and GA were significantly decreased 1 month after starting linagliptin therapy, whereas the IL-6 levels were significantly decreased 6 months after starting linagliptin therapy. Linagliptin 176-187 interleukin 6 Homo sapiens 111-115 25429809-14 2014 The plasma levels of TNF-alpha, IL-1beta, and IL-6 from site B after CPFA was performed for the second time were significantly lower than those from site A before CPFA was performed for the second time (with t values from 1.87 to 5.93, P <0.05 or P <0.01). cpfa 69-73 interleukin 6 Homo sapiens 46-50 24363043-8 2014 Treatment with PKA selective 6-Bnz-cAMP or Epac selective 8-CPT-2Me-cAMP cAMP analogs revealed a predominant role for PKA in cAMP-mediated induction of IL-6. 8-cpt-2me-camp camp 58-77 interleukin 6 Homo sapiens 152-156 24258317-3 2014 We also demonstrate reduced LPS-induced pro-inflammatory interleukin-6 and tumor necrosis factor alpha in human peripheral blood mononuclear cells preincubated with fluoxetine. Fluoxetine 165-175 interleukin 6 Homo sapiens 57-70 24672701-14 2014 IL-6 levels of lornoxicam group were statistical significant lower at 1st postoperative day compared to them of control group (113+-49 and 177+-20 respectively, P=0.008). lornoxicam 15-25 interleukin 6 Homo sapiens 0-4 26233874-7 2015 SES decreased inflammation, lowering tumor necrosis factor-alpha (P = 0.0006) and interleukin-6 levels (P = 0.0112), decreasing polymorphonuclear cells and preventing nuclear factor-kappaB activity (P = 0.0259). ses 0-3 interleukin 6 Homo sapiens 82-95 24713927-6 2014 Combining MLN4924 with the proteasome inhibitor bortezomib induces synergistic apoptosis in MM cell lines which can overcome the prosurvival effects of growth factors such as interleukin-6 and insulin-like growth factor-1. pevonedistat 10-17 interleukin 6 Homo sapiens 175-221 26334856-9 2015 CONCLUSIONS: This study demonstrates that methylprednisolone is effective for ensuring better myocardial protection during cardiac surgery by suppressing the inflammatory response via decreasing the levels of IL-6 and by increasing anti-inflammatory activity through IL-10. Methylprednisolone 42-60 interleukin 6 Homo sapiens 209-213 24788721-9 2014 Immuno-suppressive effects of ZEA were further revealed through the suppression of lipopolysaccharide (LPS)-induced expression of pro-inflammatory cytokines (IL-6, IL-8 and IL-1beta). Zearalenone 30-33 interleukin 6 Homo sapiens 158-162 24013551-5 2014 The up regulation in nitrite release, cell proliferation, and release of IL-6 and IL-1 beta in LPS stimulated human astrocytoma cells were dose-dependently inhibited by co-treatment with guggulipid. guggulu extract 187-197 interleukin 6 Homo sapiens 73-77 24408019-7 2014 Overall, a significant association between IL6 -634C/G polymorphism and LC susceptibility was observed for GG + CG vs. CC (OR = 1.33, 95% CI 1.20-1.47, P < 0.00001). cysteinylglycine 112-114 interleukin 6 Homo sapiens 43-46 24600548-7 2014 IL-6 within 73-96 h after TBI was significantly lower in the epoprostenol group compared to the placebo group (p = 0.04). Epoprostenol 61-73 interleukin 6 Homo sapiens 0-4 24600548-10 2014 CONCLUSIONS: Administration of the prostacyclin analogue epoprostenol significantly decreased CRP and, to some extent, IL-6 levels in patients with severe TBI compared to placebo. Epoprostenol 35-47 interleukin 6 Homo sapiens 119-123 24600548-10 2014 CONCLUSIONS: Administration of the prostacyclin analogue epoprostenol significantly decreased CRP and, to some extent, IL-6 levels in patients with severe TBI compared to placebo. Epoprostenol 57-69 interleukin 6 Homo sapiens 119-123 25727025-8 2015 Positive significant correlations were detected between serum neopterin and ESR, TNF-alpha, IL-6, MCP-1, and JADAS-27 (p<0.05). Neopterin 62-71 interleukin 6 Homo sapiens 92-96 24440572-11 2014 Inflammation was observed in the congestive liver, and there was an increase in interleukin-6, which also induced hepcidin and was induced by free heme and hemoglobin via Toll-like receptor 4. Heme 147-151 interleukin 6 Homo sapiens 80-93 25738314-7 2015 Furthermore, the data suggested that the functions of miR-125b in arteriosclerosis obliterans may be associated with transgelin, lectin-type oxidized LDL receptor-1, vascular endothelial-cadherin, intercellular adhesion molecule-1, interleukin-6 and monocyte chemotactic protein-1. mir-125b 54-62 interleukin 6 Homo sapiens 232-245 24396446-9 2014 The following parameters were found to be reduced following the use of methylprednisolone: Interleukin (IL)-6 immediately following surgery and on postoperative days (PODs) 1 and 3; IL-8 immediately following surgery; and PaO2/FiO2 on POD 3. Methylprednisolone 71-89 interleukin 6 Homo sapiens 91-109 24414739-10 2014 The high FeNO group also was found to have an elevation in IL-5 (p = 0.04), IL-6 (p = 0.003), IL-10 (p = 0.002), and total serum IgE (p < 0.001), after adjustment by age, sex, height, body mass index, and atopy and asthma status. feno 9-13 interleukin 6 Homo sapiens 76-80 24164087-7 2014 Budesonide also reduced the concentrations of tumour necrosis factor-alpha, interleukin-1beta, interleukin-6 and interleukin-8 in bronchoalveolar lavage fluid, but increased interleukin-10 30 min after re-expansion (p < 0.05 for all measures). Budesonide 0-10 interleukin 6 Homo sapiens 95-108 26110640-14 2015 Dh404 significantly decreased production of cytokines/chemokines including IL-1beta, IL-6, IFN-gamma and MCP-1. dh404 0-5 interleukin 6 Homo sapiens 85-89 24405838-9 2014 Changes in TNF-alpha, IL-6 and MCP-1 levels after spironolactone treatment were significantly correlated with changes in HOMA-IR (r=0.61, r=0.55 and r=0.65, respectively; p=0.01, p=0.03 and p=0.01, respectively). Spironolactone 50-64 interleukin 6 Homo sapiens 22-26 24572452-16 2014 Regarding to cytokines levels, the levels of IL6 were significantly decreased and IL10 were significantly increased in Alfacalcidol group in comparison with the control group. alfacalcidol 119-131 interleukin 6 Homo sapiens 45-48 25230323-5 2015 Compared with placebo, DHEA administration raised levels of testosterone, androstenedione, and DHEA-sulfate (DHEA-S), and increased the percent change from baseline in fasting IL-6 mRNA, IL-6 release, plasma IL-6, and CRP and MMP-2 protein. Dehydroepiandrosterone 23-27 interleukin 6 Homo sapiens 176-180 25230323-5 2015 Compared with placebo, DHEA administration raised levels of testosterone, androstenedione, and DHEA-sulfate (DHEA-S), and increased the percent change from baseline in fasting IL-6 mRNA, IL-6 release, plasma IL-6, and CRP and MMP-2 protein. Dehydroepiandrosterone 23-27 interleukin 6 Homo sapiens 187-191 25230323-5 2015 Compared with placebo, DHEA administration raised levels of testosterone, androstenedione, and DHEA-sulfate (DHEA-S), and increased the percent change from baseline in fasting IL-6 mRNA, IL-6 release, plasma IL-6, and CRP and MMP-2 protein. Dehydroepiandrosterone 23-27 interleukin 6 Homo sapiens 187-191 25907222-0 2015 The reduction of circulating levels of IL-6 in pregnant women with preeclampsia by magnesium sulphate and nifedipine: In vitro evidence for potential mechanisms. Magnesium Sulfate 83-101 interleukin 6 Homo sapiens 39-43 25907222-0 2015 The reduction of circulating levels of IL-6 in pregnant women with preeclampsia by magnesium sulphate and nifedipine: In vitro evidence for potential mechanisms. Nifedipine 106-116 interleukin 6 Homo sapiens 39-43 25907222-8 2015 RESULTS: Circulating levels of IL-6 in preeclampsia were reduced significantly following administration of MgSO4. Magnesium Sulfate 107-112 interleukin 6 Homo sapiens 31-35 24877120-6 2014 rSLURP-2 inhibited IL-1 beta-induced secretion of IL-6 and TLR4- and TLR9-dependent induction of CXCL10 and IL-8, respectively, in CCL-241. Cefaclor 131-134 interleukin 6 Homo sapiens 50-54 24261754-8 2014 Multivariate Cox regression analysis identified low serum IL-6 and normalisation of MMP-3 levels at cessation of TCZ as independent predictive markers for longer duration of LDA. lda 174-177 interleukin 6 Homo sapiens 58-62 24314116-6 2013 RESULTS: There was a statistically significant association between first and last-day average PM2.5 and 8-OHdG (21% increase, 95% CI: 2, 42%) and first and last-day average OC and IL-6 levels (18% increase 95% CI: 1, 37%) per IQR in exposure. 8-ohdg 104-110 interleukin 6 Homo sapiens 180-184 24149444-8 2013 Selenium was inversely associated with adiponectin, whereas magnesium was positively associated with IL-6. Magnesium 60-69 interleukin 6 Homo sapiens 101-105 25907222-9 2015 In vitro, MgSO4 reversed the activation of endothelial cells induced by IL-6 but not by necrotic trophoblastic debris. Magnesium Sulfate 10-15 interleukin 6 Homo sapiens 72-76 24269928-6 2014 Carbachol concentration-dependently enhanced the production of IL-1beta-induced IL-6 and IL-8, which was blocked by the simultaneous addition of tiotropium. Tiotropium Bromide 145-155 interleukin 6 Homo sapiens 80-84 25907222-10 2015 The effect of MgSO4 in reversing the IL-6 induced activation of endothelial cells was not dependent upon nitric oxide synthetase. Magnesium Sulfate 14-19 interleukin 6 Homo sapiens 37-41 25907222-11 2015 Treating placental explants with MgSO4 prevented the production of necrotic trophoblastic debris induced by IL-6. Magnesium Sulfate 33-38 interleukin 6 Homo sapiens 108-112 25907222-12 2015 DISCUSSION: we demonstrated that IL-6 levels drop following treatment with MgSO4 and nifedipine in vivo, and have identified several mechanisms by which this positive effect on IL-6 may occur in vitro. Magnesium Sulfate 75-80 interleukin 6 Homo sapiens 33-37 24298938-4 2013 We found that andrographolide pretreatment significantly restored the glutathione level in CSE-exposed A549 cells, coupled with reduced inhibitor kappaB (IkappaB)-alpha phosphorylation and p65 nuclear translocation and interleukin (IL)-8 and IL-6 secretion. andrographolide 14-29 interleukin 6 Homo sapiens 242-246 25004875-4 2014 In addition, pretreatment with baicalein inhibited LPS-induced early (e.g., tumor necrosis factor-alpha (TNF-alpha) and interleukin-6) and late (e.g., high mobility group box 1 (HMGB1) pro-inflammatory cytokine release, inducible nitric oxide synthase (iNOS) expression and NO production. baicalein 31-40 interleukin 6 Homo sapiens 120-133 24298938-8 2013 In contrast, miR-218 silencing enhanced IkappaB-alpha phosphorylation and p65 nuclear accumulation in cells with andrographolide pretreatment and reversed andrographolide-mediated reduction of IL-6 and IL-8 production. andrographolide 113-128 interleukin 6 Homo sapiens 193-197 24298938-8 2013 In contrast, miR-218 silencing enhanced IkappaB-alpha phosphorylation and p65 nuclear accumulation in cells with andrographolide pretreatment and reversed andrographolide-mediated reduction of IL-6 and IL-8 production. andrographolide 155-170 interleukin 6 Homo sapiens 193-197 24088862-1 2013 The Verigene Clostridium difficile Nucleic Acid test (Verigene CDF test) (Nanosphere, Northbrook, IL) is a multiplex qualitative PCR assay that utilizes a nanoparticle-based array hybridization method to detect C. difficile tcdA and tcdB in fecal specimens. tcda 224-228 interleukin 6 Homo sapiens 63-66 25907222-12 2015 DISCUSSION: we demonstrated that IL-6 levels drop following treatment with MgSO4 and nifedipine in vivo, and have identified several mechanisms by which this positive effect on IL-6 may occur in vitro. Magnesium Sulfate 75-80 interleukin 6 Homo sapiens 177-181 25907222-12 2015 DISCUSSION: we demonstrated that IL-6 levels drop following treatment with MgSO4 and nifedipine in vivo, and have identified several mechanisms by which this positive effect on IL-6 may occur in vitro. Nifedipine 85-95 interleukin 6 Homo sapiens 33-37 25907222-12 2015 DISCUSSION: we demonstrated that IL-6 levels drop following treatment with MgSO4 and nifedipine in vivo, and have identified several mechanisms by which this positive effect on IL-6 may occur in vitro. Nifedipine 85-95 interleukin 6 Homo sapiens 177-181 25722071-9 2015 Budesonide was also able to reduce the release of IL-6 and TNF-alpha by PBMC of asthmatics. Budesonide 0-10 interleukin 6 Homo sapiens 50-54 24088862-1 2013 The Verigene Clostridium difficile Nucleic Acid test (Verigene CDF test) (Nanosphere, Northbrook, IL) is a multiplex qualitative PCR assay that utilizes a nanoparticle-based array hybridization method to detect C. difficile tcdA and tcdB in fecal specimens. trimethylaminocarboxyldihydroboran 233-237 interleukin 6 Homo sapiens 63-66 24488902-10 2014 Tiopronin can reduce the levels of ET, leptin, IL-6 and IL-8 for treatment of NAFLD. Tiopronin 0-9 interleukin 6 Homo sapiens 47-51 24231099-11 2013 In Study 2, PQQ supplementation resulted in significant decreases in the levels of plasma C-reactive protein, IL-6 and urinary methylated amines such as trimethylamine N-oxide, and changes in urinary metabolites consistent with enhanced mitochondria-related functions. PQQ Cofactor 12-15 interleukin 6 Homo sapiens 110-114 25722071-11 2015 This event is associated to the decreased release of IL-6 and TNF-alpha in PBMC treated with budesonide. Budesonide 93-103 interleukin 6 Homo sapiens 53-57 25903726-2 2015 At 24h, ketamine dose-dependently (100-500 muM) decreased IL-6 and TNFalpha production and gene expression and, at clinically relevant concentration (100 muM), augmented IL-beta release and gene expression in both unstimulated and cytokine-stimulated cells. Ketamine 8-16 interleukin 6 Homo sapiens 58-62 25515776-6 2015 Poly(dA:dT) induced the expression of pro-inflammatory cytokine genes including IFN-beta, TNF-alpha, IL-6 and IL-8 as well, whereas the pro-inflammatory cytokine production was suppressed by RIG-I siRNA, but not by AIM2 siRNA. amsonic acid 5-7 interleukin 6 Homo sapiens 101-105 24822073-7 2014 Reduced IL-6 levels in the serum also indicate the effects of ectoine on systemic inflammation. ectoine 62-69 interleukin 6 Homo sapiens 8-12 25461668-11 2015 Incubation of cells with IL6 led to tetranucleotide frameshifts, the signature for EMAST. tetranucleotide 36-51 interleukin 6 Homo sapiens 25-28 25002916-11 2013 Deferoxamine significantly reduced cytotoxicity and IL-6 and IL-8 secretion whereas Polymyxin B did not. Deferoxamine 0-12 interleukin 6 Homo sapiens 52-56 23981042-6 2013 Also, that APDs inhibited the production of LPS-stimulated macrophages IL-6 and IL-8 suggests that risperidone and clozapine may inhibit inflammation. Clozapine 115-124 interleukin 6 Homo sapiens 71-75 24312369-6 2013 RESULTS: We observed lower baseline levels of IL-6 (p = 0.041), GCSF (p = 0.036) and LBP (p = 0.016) in TB-IRIS patients. Terbium 104-106 interleukin 6 Homo sapiens 46-50 24640096-6 2013 The presence of chromium-cobalt or chromium-nickel constructions leads to an increase of MMP-2, IL-lf and IL-6 content in oral fluid. chromium-cobalt 16-31 interleukin 6 Homo sapiens 106-110 25547897-7 2015 Hcy exposure also significantly increased the mRNA levels of tumor necrosis factor alpha, interleukin (IL)-6, and IL-1beta, as well as the level of Hcy-inducible endoplasmic reticulum (ER) stress protein, a marker of ER stress, in Hcy-exposed cultures compared with controls. Homocysteine 0-3 interleukin 6 Homo sapiens 90-108 25637769-6 2015 Pre-exposure of PZ-DHA ester was more effective in reducing tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and cyclooxygenase-2 (COX-2) protein levels compared to DHA and nimesulide. Docosahexaenoic Acids 19-22 interleukin 6 Homo sapiens 101-114 25637769-6 2015 Pre-exposure of PZ-DHA ester was more effective in reducing tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and cyclooxygenase-2 (COX-2) protein levels compared to DHA and nimesulide. Docosahexaenoic Acids 19-22 interleukin 6 Homo sapiens 116-120 25201048-4 2015 S1P also induced PGE2 and IL-6 secretion which were reduced by the inhibitors of COX-2 (NS-398 and celecoxib). Celecoxib 99-108 interleukin 6 Homo sapiens 26-30 24640096-6 2013 The presence of chromium-cobalt or chromium-nickel constructions leads to an increase of MMP-2, IL-lf and IL-6 content in oral fluid. nichrome 35-50 interleukin 6 Homo sapiens 106-110 23084463-9 2013 Moreover, there was a significant positive correlation between serum IL-6 levels and plasma ammonia levels (r=0.58, P<0.05) in cirrhotic patients with OHE, but not in patients without OHE (r=0.42, P>0.05) or healthy controls (r=0.27, P>0.05). Ammonia 92-99 interleukin 6 Homo sapiens 69-73 23084463-10 2013 The correlation between IL-6 and ammonia was independent of infectious precipitating factors. Ammonia 33-40 interleukin 6 Homo sapiens 24-28 24056475-12 2013 One-year traffic-NO2 exposure was associated with higher IL-6 levels with each additional IL6-174C allele, and 1-year heating-SO2 exposure with higher levels of TNF-alpha in TNF-308AA homozygotes versus -308G carriers. Nitrogen Dioxide 17-20 interleukin 6 Homo sapiens 57-61 23084463-11 2013 CONCLUSIONS: The results of the present study suggest that IL-6 might be involved in the mechanism by which ammonia contributes to the pathogenesis of OHE. Ammonia 108-115 interleukin 6 Homo sapiens 59-63 25835116-9 2015 Furthermore, patients on both rifaximin and norfloxacin therapies showed a statistically significant decrease in TNF-alpha and IL-6 serum levels compared with their baseline levels (p=0.000 and p=0.000, respectively). Norfloxacin 44-55 interleukin 6 Homo sapiens 127-131 25104172-0 2015 Serum interleukin-6 is a predictive biomarker for ketamine"s antidepressant effect in treatment-resistant patients with major depression. Ketamine 50-58 interleukin 6 Homo sapiens 6-19 24062615-7 2013 RESULTS: We have demonstrated that budesonide concentration-dependently (10(-10)-10(-7) M) inhibited IL-6, IL-8, MMP-1, and MMP-3 release by HFL-1 cells in response to IL-1beta plus TNF-alpha. Budesonide 35-45 interleukin 6 Homo sapiens 101-105 24056475-12 2013 One-year traffic-NO2 exposure was associated with higher IL-6 levels with each additional IL6-174C allele, and 1-year heating-SO2 exposure with higher levels of TNF-alpha in TNF-308AA homozygotes versus -308G carriers. Nitrogen Dioxide 17-20 interleukin 6 Homo sapiens 90-93 23538947-4 2013 Sphingosine-1-phosphate (S1P) induces various cytokine secretions including IL-6 in different cell types. sphingosine 1-phosphate 0-23 interleukin 6 Homo sapiens 76-80 25760537-4 2015 Formation of alpha-hydroxytriazolam catalyzed by CYP3A was decreased by IL-1beta and IL-6. alpha-hydroxytriazolam 13-35 interleukin 6 Homo sapiens 85-89 23538947-4 2013 Sphingosine-1-phosphate (S1P) induces various cytokine secretions including IL-6 in different cell types. sphingosine 1-phosphate 25-28 interleukin 6 Homo sapiens 76-80 25880052-6 2015 RESULTS: Pentoxifylline administration did not significantly affect troponin-T (p=0.68), but it reduced tumor necrosis factor-alpha (p=0.01) and interleukin-6 (p=0.01). Pentoxifylline 9-23 interleukin 6 Homo sapiens 145-158 23936533-6 2013 Administration of pharmacologic agents that increase STAT3 phosphorylation/activation (Valproic Acid) or increase STAT3 levels (Interleukin 6) also significantly enhanced oHSV replication. ohsv 171-175 interleukin 6 Homo sapiens 128-141 23538947-8 2013 IL-6 secretion was completely inhibited via inhibitor of transcription (Actinomycin D) or protein synthesis (Cycloheximide) confirming that IL-6 releases constitutively from BeWo cells. Dactinomycin 72-85 interleukin 6 Homo sapiens 0-4 25824798-5 2015 HT-29 cells demonstrated significantly increased RIPK1, RIPK3 and MLKL expression in response to cobalt chloride plus z-VAD treatment, which was accompanied by drastically increased IL1alpha and IL6 expression, substantiating the notion that necrosis can induce profound immune reactions. z-vad 118-123 interleukin 6 Homo sapiens 195-198 23538947-8 2013 IL-6 secretion was completely inhibited via inhibitor of transcription (Actinomycin D) or protein synthesis (Cycloheximide) confirming that IL-6 releases constitutively from BeWo cells. Dactinomycin 72-85 interleukin 6 Homo sapiens 140-144 23939801-6 2013 Moreover, (R)-naringenin significantly reduced proinflammatory cytokine levels such as those of TNF-alpha and, with less potency, IL-6. (R)-naringenin 10-24 interleukin 6 Homo sapiens 130-134 23777448-10 2013 Moreover, DMC suppressed LPS-induced IL-6 production, thereby blocking subsequent Stat3 activation. demethoxycurcumin 10-13 interleukin 6 Homo sapiens 37-41 23278857-6 2013 Shift-and-persist partially mediated the interaction of SES and role models on IL-6. ses 56-59 interleukin 6 Homo sapiens 79-83 25420194-6 2015 We found that the infarct and border zones of rat myocardium treated with h-AECs had higher expression levels of the human-origin cytokines ANG, EGF, IL-6, and MCP-1 compared to the tissues of saline-treated rats. h-aecs 74-80 interleukin 6 Homo sapiens 150-154 23874068-1 2013 UNLABELLED: The present study aimed to assess the effect of supplementation of omega-3 and/or vitamin C on serum interleukin-6 and high sensitivity C-reactive protein concentration and depression scores among shift workers in Shahid Tondgoyan oil refinery. omega-3 79-86 interleukin 6 Homo sapiens 113-126 25858261-0 2015 Dengue Patients Treated with Doxycycline Showed Lower Mortality Associated to a Reduction in IL-6 and TNF Levels. Doxycycline 29-40 interleukin 6 Homo sapiens 93-97 23807226-0 2013 Hypericin-photodynamic therapy leads to interleukin-6 secretion by HepG2 cells and their apoptosis via recruitment of BH3 interacting-domain death agonist and caspases. hypericin 0-9 interleukin 6 Homo sapiens 40-53 25858261-6 2015 Moreover, administration of doxycycline resulted in a significant (p<0.01) decrease in levels of TNF and IL-6 versus controls in the tests performed during follow-up (day 3, 5 and 7). Doxycycline 28-39 interleukin 6 Homo sapiens 108-112 25126764-7 2014 The blockage of CD44 expression by siRNA resulted in the attenuation of IL-6 and chemokines expression in LMW HA treated NHDF suggesting the involvement of CD44 in LMW HA mediated NHDF activation. nhdf 121-125 interleukin 6 Homo sapiens 72-76 25126764-7 2014 The blockage of CD44 expression by siRNA resulted in the attenuation of IL-6 and chemokines expression in LMW HA treated NHDF suggesting the involvement of CD44 in LMW HA mediated NHDF activation. nhdf 180-184 interleukin 6 Homo sapiens 72-76 23945326-0 2013 [A case of bladder cancer producing granulocyte colony-stimulating factor and interleukin-6 causing respiratory failure treated with neoadjuvant systemic chemotherapy along with sivelestat]. sivelestat 178-188 interleukin 6 Homo sapiens 78-91 23617551-10 2013 Inhaled budesonide significantly reduced LPS-induced IL-1beta, IL-6, IL-8 and TNF-alpha secretion, while inhaled formoterol had no such effect; however when combined, the inhibitory effect of budesonide was significantly increased by formoterol. Budesonide 8-18 interleukin 6 Homo sapiens 63-67 23541634-6 2013 Tubastatin, a potent human HDAC6 inhibitor with an IC50 of 11 nM showed significant inhibition of TNF-alpha and IL-6 in LPS stimulated human THP-1 macrophages with an IC50 of 272 nM and 712 nM respectively. tubastatin 0-10 interleukin 6 Homo sapiens 112-116 23602068-9 2013 Methylprednisolone significantly lowered concentrations of proinflammatory cytokines IL-6 and IL-8 and raised levels of anti-inflammatory IL-10. Methylprednisolone 0-18 interleukin 6 Homo sapiens 85-89 23485680-10 2013 Further, 4-ME significantly ameliorated the upregulated non-enzymatic inflammatory markers like TNF-alpha, IL-1beta, IL-6, COX-2 and PGE2. 4-methylesculetin 9-13 interleukin 6 Homo sapiens 117-121 25126764-8 2014 The importance of pro-inflammatory mediators produced by LMW HA triggered NHDF was evaluated by significant activation of blood leukocytes exhibited as increased production of IL-6 and TNF-alpha. nhdf 74-78 interleukin 6 Homo sapiens 176-180 25352622-6 2014 Transient expression of pUL7 induced phosphorylation of STAT3 and ERK1/2 MAP kinases and production of proangiogenic factors, including IL-6. pul7 24-28 interleukin 6 Homo sapiens 136-140 23734999-6 2013 By contrast, treatments with beta-caryophyllene dose-dependently inhibited mRNA expression of inducible nitric oxide synthetase, interleukin (IL)-1beta, IL-6, and cyclooxygenase 2 in C6 microglial cells, and decreased the level of nitric oxide and prostaglandin E2 at a 100 muM concentration. caryophyllene 29-47 interleukin 6 Homo sapiens 153-157 23631691-12 2013 HP enhanced production of TNF-alpha, IL-1beta, and IL-6 in PBMCs following CL097-stimulation more than LP and LP-der, whereas LP enhanced the secretion of TNF-alpha and IL-1beta in poly(I:C)- and CL097-stimulated PAMs. histidylproline 0-2 interleukin 6 Homo sapiens 51-55 24705131-5 2014 RESULTS: The presence of MIAC, HCA, or the coexistence of both was associated with higher amniotic fluid concentrations of IL-6 in both a crude and adjusted analysis. miac 25-29 interleukin 6 Homo sapiens 123-127 24705131-5 2014 RESULTS: The presence of MIAC, HCA, or the coexistence of both was associated with higher amniotic fluid concentrations of IL-6 in both a crude and adjusted analysis. hca 31-34 interleukin 6 Homo sapiens 123-127 23488631-3 2013 SI, AD, and DM reduced a mean phorbol-12-myristate-13-acetate/ionomycin (PMA/I)-stimulated release of the pro-inflammatory interleukins IL-6 and IL-8 by more than 50% (p < 0.05). ad 4-6 interleukin 6 Homo sapiens 136-140 23603911-6 2013 To assess the proinflammatory potency of pnLTA, we generated a (lipopeptide-free) Deltalgt mutant of strain D39Deltacps, isolated its pnLTA, and showed that it is capable of inducing IL-6 release in human mononuclear cells, independent of TLR2 activation. pnlta 41-46 interleukin 6 Homo sapiens 183-187 22727544-8 2013 Taurolidine inhibited immunoglobulin (IL)-6, IL-8 and tumor necrosis factor-alpha expression in a dose dependent-fashion in both, pediatric oncology patients and healthy controls. taurolidine 0-11 interleukin 6 Homo sapiens 22-43 23562757-7 2013 These results demonstrate that AEE and 2Ph affect the stimulation of DCs and their ability to stimulate allogeneic CD4(+) T cells by reducing the production of IFN-gamma, IL-12 p40, IL-6 and IL-23. UNII-H4K6WCP5DQ 39-42 interleukin 6 Homo sapiens 182-186 25128276-7 2014 ALO attenuated CCI induced up-regulation of expressions of NF-kappaB, TNF-alpha, IL-6, IL-1beta at the dose of 80mg/kg (i.p.). CCI 15-18 interleukin 6 Homo sapiens 81-85 23459983-0 2013 Selenium is inversely associated with interleukin-6 in the elderly. Selenium 0-8 interleukin 6 Homo sapiens 38-51 25074847-8 2014 Artesunate also produced significant inhibition of TNFalpha and IL-6 production in activated BV2 microglia. Artesunate 0-10 interleukin 6 Homo sapiens 64-68 23047422-6 2013 In contrast, clonidine at <10(-9) M increased IL-6, while at >10(-5) M increased IL-1beta and decreased TNF-alpha levels. Clonidine 13-22 interleukin 6 Homo sapiens 49-53 23459983-3 2013 In this study, we aim to investigate the association between serum selenium and the inflammatory cytokine interleukin-6 in the elderly living in long-term care facilities in Taiwan. Selenium 67-75 interleukin 6 Homo sapiens 106-119 24818664-7 2014 EhMIF induced interleukin-6 (IL-6) production. ehmif 0-5 interleukin 6 Homo sapiens 14-27 23459983-7 2013 Multiple logistic and linear regression analyses were used to examine the relationships between selenium deficiency and interleukin-6 (divided into quartiles). Selenium 96-104 interleukin 6 Homo sapiens 120-133 24818664-7 2014 EhMIF induced interleukin-6 (IL-6) production. ehmif 0-5 interleukin 6 Homo sapiens 29-33 23459983-9 2013 After adjusting for potential confounders using multiple logistic regression analysis, interleukin-6 quartiles were significantly associated with selenium deficiency. Selenium 146-154 interleukin 6 Homo sapiens 87-100 23376248-3 2013 A benzothiazole core scaffold containing compound, 9, was identified as an inhibitor of IL-6/STAT3 signaling with an IC50 of 3.567 muM. benzothiazole 2-15 interleukin 6 Homo sapiens 88-92 23459983-10 2013 Compared to the interleukin-6 quartile I, the adjusted odds ratios of having selenium deficiency for interleukin-6 quartile II, III, IV were 1.00(0.50~2.01), 1.24 (0.62~2.50), and 2.35(1.15~4.83), respectively. Selenium 77-85 interleukin 6 Homo sapiens 101-114 24970858-16 2014 Significant adjusted differences were found between DHA and control for both gingival crevicular fluid hsCRP (-5.3 ng/mL, standard error [SE] = 2.4, p = .03) and IL-1beta (-20.1 pg/mL, SE = 8.2, p = .02) but not IL-6 (0.02 pg/mL, SE = 0.71, p = .98) or systemic hsCRP (-1.19 mg/L, SE = 0.90, p = .20). Docosahexaenoic Acids 52-55 interleukin 6 Homo sapiens 212-216 23459983-11 2013 The increasing odds ratios for selenium deficiency in higher interleukin-6 quartiles revealed dose-response effects (p < 0.05). Selenium 31-39 interleukin 6 Homo sapiens 61-74 23459983-12 2013 Moreover, multiple linear regression analysis showed that serum selenium was significantly inversely associated with interleukin-6 after adjusting for potential confounders. Selenium 64-72 interleukin 6 Homo sapiens 117-130 23459983-13 2013 CONCLUSIONS: Serum selenium was inversely associated with inflammatory cytokine interleukin-6 among elderly living in long-term care facilities in Taiwan. Selenium 19-27 interleukin 6 Homo sapiens 80-93 24854955-9 2014 The mRNA for interleukin-6 and tumor necrosis factor-alpha was higher with AEA but lower with DHA and docosahexaenoyl ethanolamide (DHEA), supporting previous findings that the EC AEA supports activation of the COX system. Dehydroepiandrosterone 132-136 interleukin 6 Homo sapiens 13-58 23235712-0 2013 Effects of telmisartan therapy on interleukin-6 and tumor necrosis factor-alpha levels: a meta-analysis of randomized controlled trials. Telmisartan 11-22 interleukin 6 Homo sapiens 34-47 23235712-2 2013 Therefore, telmisartan would be expected to reduce interleukin-6 (IL-6) or tumor necrosis factor-alpha (TNF-alpha). Telmisartan 11-22 interleukin 6 Homo sapiens 51-64 22764197-10 2013 Selenium supplementation also hindered an increase in IL-6 levels compared with the placebo group (P = 0.016). Selenium 0-8 interleukin 6 Homo sapiens 54-58 23235712-2 2013 Therefore, telmisartan would be expected to reduce interleukin-6 (IL-6) or tumor necrosis factor-alpha (TNF-alpha). Telmisartan 11-22 interleukin 6 Homo sapiens 66-70 23235712-3 2013 To determine whether telmisartan reduces IL-6 or TNF-alpha, we performed the first meta-analysis of randomized controlled trials of telmisartan therapy. Telmisartan 21-32 interleukin 6 Homo sapiens 41-45 24968069-3 2014 Although most patients treated with clozapine do not develop agranulocytosis, most do have an immune response with an increase in inflammatory cytokines such as IL-6 and a release of immature neutrophils with neutrophilia rather than agranulocytosis. Clozapine 36-45 interleukin 6 Homo sapiens 161-165 22740381-5 2013 Mechanistically, LfcinB attenuated the effects of IL-1beta and FGF-2 on the expression of cartilage-degrading enzymes (MMP-1, MMP-3, and MMP-13), destructive cytokines (IL-1beta and IL-6), and inflammatory mediators (iNOS and TLR2). LFcinB 17-23 interleukin 6 Homo sapiens 182-186 24799081-6 2014 The IC50 value of A. paniculata extract was significantly higher than that of andrographolide on IL-1alpha, IL-1beta, and IL-6 (p < 0.001) release. andrographolide 78-93 interleukin 6 Homo sapiens 122-126 24799081-7 2014 The IC50 values of andrographolide for IL-1alpha, IL-1beta, and IL-6 were significantly higher (p < 0.001) than that of dexamethasone. andrographolide 19-34 interleukin 6 Homo sapiens 64-68 24998372-4 2014 RESULTS: Treatment with formoterol and budesonide 72 h before and after RV14 infection reduced RV14 titers and cytokine concentrations, including interleukin (IL)-1beta, IL-6 and IL-8, in supernatants and viral RNA within cells. Budesonide 39-49 interleukin 6 Homo sapiens 170-174 23325450-6 2013 RESULTS: Compared to placebo, IPE 4 g/day significantly decreased Ox-LDL (13 %, p < 0.0001, ANCHOR), Lp-PLA(2) (14 %, p < 0.001, MARINE; 19 %, p < 0.0001, ANCHOR), and hsCRP levels (36 %, p < 0.01, MARINE; 22 %, p < 0.001, ANCHOR), but did not significantly change ICAM-1 and IL-6 levels. eicosapentaenoic acid ethyl ester 30-33 interleukin 6 Homo sapiens 291-295 23150523-7 2013 HIV(+) human macrophages treated with sulfated dehydroepiandrosterone (DHEA-S) showed suppression of inflammatory gene (IL-1beta, IL-6, TNF-alpha) expression. Dehydroepiandrosterone 47-69 interleukin 6 Homo sapiens 130-134 23150523-7 2013 HIV(+) human macrophages treated with sulfated dehydroepiandrosterone (DHEA-S) showed suppression of inflammatory gene (IL-1beta, IL-6, TNF-alpha) expression. Dehydroepiandrosterone 71-77 interleukin 6 Homo sapiens 130-134 23781253-8 2013 Remarkably, DXM decreased the LPS-induced surface expression of CD80, CD83, and HLA-DR and the secretion of IL-6 and IL-12 in human monocyte-derived dendritic cells (MDDCs). Dextromethorphan 12-15 interleukin 6 Homo sapiens 108-112 23261363-3 2013 Procyanidin C1 inhibited inducible nitric oxide synthase-mediated nitric oxide production and the release of pro-inflammatory cytokines (interleukin-6 and tumor necrosis factor-alpha) in lipopolysaccharide (LPS)-induced macrophages. Procyanidin C1 0-14 interleukin 6 Homo sapiens 137-182 24696473-5 2014 EBV infection also activated the mitogen-activated protein kinase (MAPK) p38 and NF-kappaB, and the inhibition of these two pathways with SB202190 and SN50 almost abrogated TNF-alpha and IL-6 production and inhibited IDO production. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 138-146 interleukin 6 Homo sapiens 187-191 23674892-10 2013 CpG oligodeoxynucleotides loaded onto BNNS-CS complexes significantly enhanced production of interleukin-6 and tumor necrosis factor-alpha by peripheral blood mononuclear cells compared with CpG oligodeoxynucleotides directly loaded onto BNNS, or when Lipofectamine 2000 was used as the carrier. bnns-cs 38-45 interleukin 6 Homo sapiens 93-138 24361422-1 2014 An ultrasensitive electrochemical immunoassay was developed for rapid detection of interleukin-6 (IL-6) and matrix metallopeptidase-9 (MMP-9); the method utilized PS@PDA-metal nanocomposites based on graphene nanoribbon (GNR)-modified heated screen-printed carbon electrode (HSPCE). Graphite 200-208 interleukin 6 Homo sapiens 83-96 24964617-6 2014 RESULTS: The section of the IL-6, TNF-alpha, IL-1beta and IL-8 were the highest when THP-1 cells were exposed to NiSO4, DNCB and K2Cr2O7 for 6h, PPDA and TDI for 12h. 4-(2'-pyridyldithio)benzyldiazoacetate 145-149 interleukin 6 Homo sapiens 28-32 24964617-7 2014 The production of IL-6 were approximately 40, 25, 20, 50 and 50 times for five kinds chemical allergens NiSO4, DNCB, K2Cr2O7, PPDA and TDI respectively at the optimum time points and the optimal concentration compared to the control group. 4-(2'-pyridyldithio)benzyldiazoacetate 126-130 interleukin 6 Homo sapiens 18-22 23275042-9 2013 High-dose octreotide administration within 48h after AP onset may efficiently reduce the risk of SAP developing and partly attenuate SAP through raising plasma SST to a normal level and decreasing IL-6 and TNF-alpha. Octreotide 10-20 interleukin 6 Homo sapiens 197-201 23674892-10 2013 CpG oligodeoxynucleotides loaded onto BNNS-CS complexes significantly enhanced production of interleukin-6 and tumor necrosis factor-alpha by peripheral blood mononuclear cells compared with CpG oligodeoxynucleotides directly loaded onto BNNS, or when Lipofectamine 2000 was used as the carrier. bnns 38-42 interleukin 6 Homo sapiens 93-138 24722289-9 2014 Ruboxistaurin significantly attenuated gut damage and decreased the serum levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). ruboxistaurin 0-13 interleukin 6 Homo sapiens 128-141 24030317-0 2013 Niflumic acid reduces histamine-induced interleukin-6 and -8 expression in human conjunctival epithelial cells. Niflumic Acid 0-13 interleukin 6 Homo sapiens 40-60 24722289-9 2014 Ruboxistaurin significantly attenuated gut damage and decreased the serum levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). ruboxistaurin 0-13 interleukin 6 Homo sapiens 143-147 24370115-0 2014 Ultrasensitive IL-6 electrochemical immunosensor based on Au nanoparticles-graphene-silica biointerface. Graphite 75-83 interleukin 6 Homo sapiens 15-19 22516310-0 2012 Effect of celecoxib add-on treatment on symptoms and serum IL-6 concentrations in patients with major depressive disorder: randomized double-blind placebo-controlled study. Celecoxib 10-19 interleukin 6 Homo sapiens 59-63 22516310-1 2012 BACKGROUND: It has been proposed that the mechanism of the antidepressant effect of celecoxib is linked to its anti-inflammatory action and particularly its inhibitory effect on pro-inflammatory cytokines (e.g. interleukin-6(IL-6)). Celecoxib 84-93 interleukin 6 Homo sapiens 211-224 23350010-6 2013 Interestingly, production of IL-6 at 6 hours by THP-1 cells stimulated with live M. leprae and M. bovis BCG was dependent on pretreatment with 1,25-dihydroxyvitamin D(3) (VD). 1,25-dihydroxyvitamin D 143-166 interleukin 6 Homo sapiens 29-33 22516310-1 2012 BACKGROUND: It has been proposed that the mechanism of the antidepressant effect of celecoxib is linked to its anti-inflammatory action and particularly its inhibitory effect on pro-inflammatory cytokines (e.g. interleukin-6(IL-6)). Celecoxib 84-93 interleukin 6 Homo sapiens 225-229 22516310-2 2012 We measured changes in serum IL-6 concentrations and depressive symptoms following administration of celecoxib in patients with major depressive disorder (MDD). Celecoxib 101-110 interleukin 6 Homo sapiens 29-33 22516310-5 2012 RESULTS: The celecoxib group showed significantly greater reduction in serum IL-6 concentrations (mean difference (95%CI)=0.42(0.30 to 0.55) pg/ml, t(35)=6.727, P<0.001) as well as Ham-D scores (mean difference (95%CI)=3.35(1.08 to 5.61), t(38)=2.99, P=0.005) than the placebo group. Celecoxib 13-22 interleukin 6 Homo sapiens 77-81 24370115-1 2014 An Interleukin-6 (IL-6) electrochemical immunosensor was fabricated based on the Au nanoparticles (AuNP)-graphene-silica sol-gel as immobilization biointerface and AuNP-polydopamine (PDA)@carbon nanotubes (CNT) as the label of HRP-bound antibodies. Graphite 105-113 interleukin 6 Homo sapiens 3-16 24370115-1 2014 An Interleukin-6 (IL-6) electrochemical immunosensor was fabricated based on the Au nanoparticles (AuNP)-graphene-silica sol-gel as immobilization biointerface and AuNP-polydopamine (PDA)@carbon nanotubes (CNT) as the label of HRP-bound antibodies. Graphite 105-113 interleukin 6 Homo sapiens 18-22 24576911-7 2014 3-fold that of the control, which could be partly explained by the increased uptake of Mn(2+) due to the up-regulation of ZIP14 by IL-6. Manganese(2+) 87-93 interleukin 6 Homo sapiens 131-135 22516310-10 2012 CONCLUSIONS: We showed that the antidepressant activity of celecoxib might be linked to its capability of reducing IL-6 concentrations. Celecoxib 59-68 interleukin 6 Homo sapiens 115-119 23327913-18 2012 The contents of TNF-alpha and IL-6 in supernatants of normal fibroblasts and scar fibroblasts in 2.00 and 4.00 mmol/L oleic acid groups were obviously higher than those in corresponding BC and EC groups (with F(TNF-alpha) values respectively 6.911, 3.818, F(IL-6) values respectively 16.939, 11.600,P < 0.05 or P < 0.01). Oleic Acid 118-128 interleukin 6 Homo sapiens 30-34 24166363-3 2014 So far, the IL-6-rezeptor-antibody tocilizumab (TCZ, RoActemtra ) is the only approved drug for the treatment of IL-6-mediated disease, including rheumatoid arthritis (RA), systemic juvenile idiopathic (sJIA) and polyarticular juvenile arthritis (pJiA), as well as Castleman"s disease (in Japan only). roactemtra 53-63 interleukin 6 Homo sapiens 12-16 24166363-3 2014 So far, the IL-6-rezeptor-antibody tocilizumab (TCZ, RoActemtra ) is the only approved drug for the treatment of IL-6-mediated disease, including rheumatoid arthritis (RA), systemic juvenile idiopathic (sJIA) and polyarticular juvenile arthritis (pJiA), as well as Castleman"s disease (in Japan only). roactemtra 53-63 interleukin 6 Homo sapiens 113-117 24415057-2 2014 We found that local cationic anesthetics such as procaine, lidocaine and tetracaine greatly facilitated the electroporation of AT2 rat prostate carcinoma cells and human skin fibroblasts (HSF). Procaine 49-57 interleukin 6 Homo sapiens 188-191 22871993-10 2012 H(2)O(2)-induced overexpression of IL-6 by melanocytes may be a molecular linkage for the oxidative stress and inflammatory/autoimmune reactions in vitiligo and may provide a novel target for the treatment of vitiligo. o(2) 4-8 interleukin 6 Homo sapiens 35-39 23327913-18 2012 The contents of TNF-alpha and IL-6 in supernatants of normal fibroblasts and scar fibroblasts in 2.00 and 4.00 mmol/L oleic acid groups were obviously higher than those in corresponding BC and EC groups (with F(TNF-alpha) values respectively 6.911, 3.818, F(IL-6) values respectively 16.939, 11.600,P < 0.05 or P < 0.01). Oleic Acid 118-128 interleukin 6 Homo sapiens 256-262 22576985-7 2012 Using ELISA assays, lithium was demonstrated to induce production of pro-inflammatory cytokines, IL-6 and TNF-alpha, while inhibiting release of anti-inflammation-related IL-2 and IL-10 in a dose-dependent fashion. Lithium 20-27 interleukin 6 Homo sapiens 97-101 24590544-10 2014 CONCLUSIONS: Our investigation suggests that the molecular action of lithium is mediated in part by its effects on the cellular and immune response to stimulus and stress followed by the interleukin 6, inhibitor of differentiation, and methane metabolism pathways. Lithium 69-76 interleukin 6 Homo sapiens 187-200 22648519-0 2012 Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling. isoliquiritigenin 0-17 interleukin 6 Homo sapiens 71-75 24589612-3 2014 RESULTS: The diabetic patients with MS had higher BMI, HbA1c, FBG, FINS, IRI, TG, TC, and SBP than those without MS. Serum IL-6 level was higher but adiponectin level was lower in patients with MS than in those without MS. Technetium 82-84 interleukin 6 Homo sapiens 123-127 22648519-6 2012 Taken together, our findings suggested that ISL could inhibit the growth of MM via blocking IL-6 signaling and might serve as a promising therapeutic agent for treatment of MM. isoliquiritigenin 44-47 interleukin 6 Homo sapiens 92-96 22105312-12 2012 DHA at low concentrations (1, 3, and 10 muM) did not afford protection, whereas at 30 muM, it caused deleterious effects, presumably by enhancing the production of NO, ROS, IL-1beta, and IL-6 and altering the intracellular calcium dynamics. Docosahexaenoic Acids 0-3 interleukin 6 Homo sapiens 187-191 22709338-7 2012 CONCLUSIONS: The results demonstrate the role of reactive oxygen and nitrogen species in the signaling pathways of IL-6. reactive oxygen and nitrogen species 49-85 interleukin 6 Homo sapiens 115-119 23045481-9 2012 TcdA/TcdB exposure increased the expression of a number of inflammatory mediators associated with human CDI, including interleukin-6 (IL-6), gamma interferon (IFN-gamma), and IL-1beta. trimethylaminocarboxyldihydroboran 5-9 interleukin 6 Homo sapiens 119-132 24296978-0 2014 Inhibition of IL-6 expression in LNCaP prostate cancer cells by a combination of atorvastatin and celecoxib. Celecoxib 98-107 interleukin 6 Homo sapiens 14-18 24296978-1 2014 In the present study, we investigated the effect of a combination of atorvastatin and celecoxib on the formation of interleukin (IL)-6, a cytokine that is increased during the progression of LNCaP tumors from androgen dependence to androgen independence. Celecoxib 86-95 interleukin 6 Homo sapiens 116-134 24296301-9 2014 Antioxidant treatments (deferoxamine mesylate, (+-)alpha-tocopherol, or tempol) suppressed BDE-47-stimulated IL-6 release by 54.1%, 56.3% and 37.7%, respectively, implicating a role for ROS in the regulation of inflammatory pathways in HTR-8/SVneo cells. Deferoxamine 24-45 interleukin 6 Homo sapiens 109-113 23045481-9 2012 TcdA/TcdB exposure increased the expression of a number of inflammatory mediators associated with human CDI, including interleukin-6 (IL-6), gamma interferon (IFN-gamma), and IL-1beta. trimethylaminocarboxyldihydroboran 5-9 interleukin 6 Homo sapiens 134-138 22823162-2 2012 In this study, we demonstrate that the Toll-like receptor-2 agonist Pam2Cys, when administered intranasally, triggers a cascade of inflammatory and innate immune signals, acting as an immunostimulant by attracting neutrophils and macrophages and inducing secretion of IL-2, IL-6, IL-10, IFN-gamma, MCP-1 and TNF-alpha. S-(2,3-bis(palmitoyloxy)propyl)cysteine 68-75 interleukin 6 Homo sapiens 274-278 23041168-11 2012 In conclusions, it is suggested that IL-1beta, IL-6, IL-8 and TNF-alpha were associated with TCE-induced hypersensitivity dermatitis. Trichloroethylene 93-96 interleukin 6 Homo sapiens 47-51 23041168-12 2012 TCOH induced IL-6 expression through activation of the NF-kappaB pathway in HaCaT cells and may play an integral role in TCE-induced skin hypersensitivity. Trichloroethylene 121-124 interleukin 6 Homo sapiens 13-17 25159306-0 2014 Antioxidant response of osteoblasts to doxycycline in an inflammatory model induced by C-reactive protein and interleukin-6. Doxycycline 39-50 interleukin 6 Homo sapiens 110-123 25530682-6 2014 The addition of the p38 MAPK inhibitor SB202190 significantly decreased IL-6 and TNF-alpha production upon LPS or LTA stimulation. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 39-47 interleukin 6 Homo sapiens 72-76 22213519-7 2012 After ADT, in contrast to the pretreatment relationship, interleukin-6 levels were positively correlated with total-testosterone concentrations (rs = 0.343, P = 0.003), and were positively correlated also with levels of androstenedione (rs = 0.351, P = 0.002) and estoradiol (rs = 0.335, P = 0.004). Androstenedione 220-235 interleukin 6 Homo sapiens 57-70 22213519-7 2012 After ADT, in contrast to the pretreatment relationship, interleukin-6 levels were positively correlated with total-testosterone concentrations (rs = 0.343, P = 0.003), and were positively correlated also with levels of androstenedione (rs = 0.351, P = 0.002) and estoradiol (rs = 0.335, P = 0.004). estoradiol 264-274 interleukin 6 Homo sapiens 57-70 24222216-6 2013 The optical densities in MTT assay of the activated, inactivated, and control groups was 1.35 +- 0.11, 1.01 +- 0.09, and 0.29 +- 0.01, respectively, which correlated positively with the initial IL-6 level in the supernatant of the VSMCs (r = 0.63, P < 0.05). vsmcs 231-236 interleukin 6 Homo sapiens 194-198 22740511-10 2012 Additionally, IL-6-induced migration was significantly diminished by phosphatidyl inositol 3-phosphate kinase (PI3K) inhibitor (wortamannin) and beta-catenin inhibitor FH535. FH535 168-173 interleukin 6 Homo sapiens 14-18 22213519-9 2012 CONCLUSIONS: Posttreatment interleukin-6 levels had a strong positive correlation with total-testosterone, androstenedione, and estradiol levels, suggesting that a regulation loop may emerge between these sex steroids and interleukin-6 during ADT. Androstenedione 107-122 interleukin 6 Homo sapiens 27-40 23564008-1 2013 We explored gum irritation and cytotoxicity caused by nickel-chromium (Ni-Cr) alloy porcelain by interleukin-8 (IL-8), interleukin-6 (IL-6) and gingival crevicular fluid (GCF) volumes at different time points peri-crown restoration. nichrome 54-69 interleukin 6 Homo sapiens 134-138 23564008-5 2013 The total amount and concentrations of IL-8 and IL-6 per site, GCF volumes increased after nickel-chromium (Ni-Cr) alloy-porcelain crown restoration, and reached its peak at the third month as the GCF volume increased by 52.20 %, the total amount and concentrations of IL-8 increased by 112.11 and 22.75 %; the total amount and concentrations of IL-6 increased by 77.66 and 17.17 % when compared to baseline. nichrome 91-106 interleukin 6 Homo sapiens 48-52 23564008-7 2013 The increase in the total amount and the concentrations of IL-8 and IL-6 and GCF volume may be related to the cytotoxicity induced by Ni-Cr alloy. nichrome 134-139 interleukin 6 Homo sapiens 68-72 22644591-4 2012 The effect of pre-treatment with Cxb formulations was evaluated for expression of prostaglandin-E2 (PGE(2)) and Interleukin-6 (IL-6) after exposure of xylene using MD. Celecoxib 33-36 interleukin 6 Homo sapiens 112-125 22464230-0 2012 Kojic acid-induced IL-6 production in human keratinocytes plays a role in its anti-melanogenic activity in skin. kojic acid 0-10 interleukin 6 Homo sapiens 19-23 22644591-4 2012 The effect of pre-treatment with Cxb formulations was evaluated for expression of prostaglandin-E2 (PGE(2)) and Interleukin-6 (IL-6) after exposure of xylene using MD. Celecoxib 33-36 interleukin 6 Homo sapiens 127-131 23331485-11 2013 CONCLUSION: The COX inhibitors indomethacin and celecoxib reduce the expression of inflammatory factors, such as COX-2 and IL-6, in FLS from the TMJ via suppression of PGE2 production. Celecoxib 48-57 interleukin 6 Homo sapiens 123-127 22522122-0 2012 Diet-derived polyphenols inhibit angiogenesis by modulating the interleukin-6/STAT3 pathway. Polyphenols 13-24 interleukin 6 Homo sapiens 64-77 23639230-8 2013 PTX alters tumor microenvironment by limiting IL-6 secretion and also by disrupting VEGF-VEGFR2 autocrine/paracrine signaling. Pentoxifylline 0-3 interleukin 6 Homo sapiens 46-50 22464230-6 2012 RESULTS: Kojic acid increased interleukin (IL)-6 and IL-8 production in melanocyte/keratinocyte co-cultures; however, IL-6 directly inhibited melanogenesis whereas IL-8 did not. kojic acid 9-19 interleukin 6 Homo sapiens 30-48 22522122-4 2012 The objectives of the current study are to investigate the inhibitory effects of these polyphenols on angiogenesis triggered by an inflammatory cytokine (IL-6) and to determine the mechanisms underlying this action. Polyphenols 87-98 interleukin 6 Homo sapiens 154-158 22522122-5 2012 We found that, among the tested polyphenols, apigenin and luteolin were the most potent angiogenesis inhibitors through their inhibitory effect on the inflammatory cytokine IL-6/STAT3 pathway. Polyphenols 32-43 interleukin 6 Homo sapiens 173-177 22464230-7 2012 In melanocyte monocultures, kojic acid did not increase IL-6 production whereas in keratinocyte monocultures it significantly up-regulated IL-6 gene and protein expression. kojic acid 28-38 interleukin 6 Homo sapiens 139-143 22522122-7 2012 Interestingly, these polyphenols also modulated the expression of IL-6 signal transducing receptor (IL-6Ralpha) and the secretion of the extracellular matrix degrading enzyme MMP-2 as well as the expression of suppressor of cytokine signaling (SOCS3) protein. Polyphenols 21-32 interleukin 6 Homo sapiens 66-70 22464230-8 2012 Therefore, the up-regulation of IL-6 in melanocyte/keratinocyte co-cultures seems to be originated from kojic acid-induced changes in keratinocytes. kojic acid 104-114 interleukin 6 Homo sapiens 32-36 24371477-10 2013 The multiple regression analysis indicated that the ALAnerv treatment was responsible for the significant decrease of IL-6 level (P = 0.008). alanerv 52-59 interleukin 6 Homo sapiens 119-123 22464230-9 2012 Anti-IL-6 antibody treatment antagonized the anti-melanogenic effect of kojic acid on the co-cultures. kojic acid 72-82 interleukin 6 Homo sapiens 5-9 22464230-10 2012 CONCLUSIONS: The pharmacological mechanism of kojic acid to explain clinically effective anti-melanogenic activity on hyper-pigmented skin is associated with the kojic acid-induced IL-6 production in keratinocytes. kojic acid 46-56 interleukin 6 Homo sapiens 181-185 22464230-10 2012 CONCLUSIONS: The pharmacological mechanism of kojic acid to explain clinically effective anti-melanogenic activity on hyper-pigmented skin is associated with the kojic acid-induced IL-6 production in keratinocytes. kojic acid 162-172 interleukin 6 Homo sapiens 181-185 23499806-0 2013 Acute peripheral administration of synthetic human GLP-1 (7-36 amide) decreases circulating IL-6 in obese patients with type 2 diabetes mellitus: a potential role for GLP-1 in modulation of the diabetic pro-inflammatory state? Amides 63-68 interleukin 6 Homo sapiens 92-96 22817337-7 2012 In most cases, oat beta-glucan resulted in a dose-dependent increase in pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) in lung and peritoneal macrophages with and without exposure to HSV-1 infection. beta-Glucans 19-30 interleukin 6 Homo sapiens 110-114 22808498-8 2012 Orthodontic structures made from chromium-cobalt, or chromium-nickel alloys in the oral cavity of these patients increased the levels of MMP-2, IL-1beta and IL-6 in oral fluid. Chromium 53-61 interleukin 6 Homo sapiens 157-161 23361365-0 2013 Docosahexaenoic acid and eicosapentaenoic acid reduce C-reactive protein expression and STAT3 activation in IL-6-treated HepG2 cells. Docosahexaenoic Acids 0-20 interleukin 6 Homo sapiens 108-112 22471285-5 2012 Interleukin (IL)-6 and IL-8 mRNA expression and protein secretion in LPS-stimulated cells were inhibited significantly by the lipophilic statin pitavastatin and the hydrophilic statin pravastatin. Pravastatin 184-195 interleukin 6 Homo sapiens 0-18 23361365-4 2013 The aims of this study were to examine the effect of the n-3 PUFAs, docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA), on the modulation of IL-6-induced CRP expression and to explore its possible mechanisms. Docosahexaenoic Acids 68-88 interleukin 6 Homo sapiens 150-154 23361365-4 2013 The aims of this study were to examine the effect of the n-3 PUFAs, docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA), on the modulation of IL-6-induced CRP expression and to explore its possible mechanisms. Docosahexaenoic Acids 90-93 interleukin 6 Homo sapiens 150-154 23361365-5 2013 We demonstrated that DHA and EPA inhibited IL-6-induced CRP protein and mRNA expression, as well as reduced CRP promoter activity in HepG2 cells. Docosahexaenoic Acids 21-24 interleukin 6 Homo sapiens 43-47 23361365-7 2013 Gel electrophoresis mobility shift assays (EMSA) showed that pretreatment with DHA and EPA decreased IL-6-induced STAT3 DNA binding activity but not C/EBPbeta. Docosahexaenoic Acids 79-82 interleukin 6 Homo sapiens 101-105 23361365-8 2013 By western blot analysis, DHA and EPA inhibited IL-6-induced STAT3 phosphorylation but not ERK1/2 or C/EBPbeta. Docosahexaenoic Acids 26-29 interleukin 6 Homo sapiens 48-52 23498057-1 2013 To investigate the effects of the commonly-used immunomodulators l-glutamine, l-alanine, and the combination of both l-alanyl-l-glutamine (Dipeptamin( )) on intracellular expression of IL-6, IL-8, and TNF-alpha during endotoxemia, lipopolysaccharide (LPS)-stimulated human monocytes in a whole blood system were investigated by flow cytometry. alanylglutamine 117-137 interleukin 6 Homo sapiens 185-189 23498057-1 2013 To investigate the effects of the commonly-used immunomodulators l-glutamine, l-alanine, and the combination of both l-alanyl-l-glutamine (Dipeptamin( )) on intracellular expression of IL-6, IL-8, and TNF-alpha during endotoxemia, lipopolysaccharide (LPS)-stimulated human monocytes in a whole blood system were investigated by flow cytometry. alanylglutamine 139-149 interleukin 6 Homo sapiens 185-189 22471522-8 2012 MitoSOX Red staining showed that IL-6 treatment attenuated late mitochondrial oxidant production in irradiated myeloma cells. MitoSox Red 0-11 interleukin 6 Homo sapiens 33-37 22611240-4 2012 Short-term exposure to a clinically effective MgSO(4) concentration in vitro substantially reduced the frequency of neonatal monocytes producing TNF-alpha and IL-6 under constitutive and TLR-stimulated conditions, decreasing cytokine gene and protein expression, without influencing cell viability or phagocytic function. Magnesium Sulfate 46-53 interleukin 6 Homo sapiens 159-163 21416238-7 2012 IL-6 in the plasma increased in the SRP group, but slightly decreased in the SRP+minocycline group (0.469 pg/ml, p = 0.172). L-seryl-AMP 36-39 interleukin 6 Homo sapiens 0-4 22345170-4 2012 Everolimus led to inhibition of protein translation, activation of p38 MAPK, and the release of proinflammatory cytokines (eg, IL-6, TNFalpha) and chemokines (eg, MCP1, Rantes) before induction of autophagic death. Everolimus 0-10 interleukin 6 Homo sapiens 127-131 23816766-8 2013 Of the cytokines released from Th2 cells, interleukin (IL)-6 was present in higher concentrations in the magnesium group at time points 2 and 3 (p<0.05). Magnesium 105-114 interleukin 6 Homo sapiens 42-60 23816766-10 2013 The IFN-gamma /IL-6, IFN-gamma /IL-4 and IFN-gamma /IL-10 ratios were lower in the magnesium group after allograft reperfusion. Magnesium 83-92 interleukin 6 Homo sapiens 15-19 21416238-7 2012 IL-6 in the plasma increased in the SRP group, but slightly decreased in the SRP+minocycline group (0.469 pg/ml, p = 0.172). L-seryl-AMP 77-80 interleukin 6 Homo sapiens 0-4 22366983-10 2012 The present study showed that patients who received sivelestat had reduced release of HMGB1, and that IL-6 levels decreased more rapidly in patients treated with sivelestat than in those who received the placebo. sivelestat 162-172 interleukin 6 Homo sapiens 102-106 22330084-0 2012 Zerumbone inhibits interleukin-6 and induces apoptosis and cell cycle arrest in ovarian and cervical cancer cells. zerumbone 0-9 interleukin 6 Homo sapiens 19-32 22277266-9 2012 Compared to controls, Quixil-treated patients demonstrated a reduction in post-tonsillectomy circulating leukocytes (29.2% vs. 45.4%, p<0.05), neutrophiles (28.3% vs. 42.1%, p<0.05), IL-6 (+1% vs. +42%, p<0.05), and TNF-alpha (+8% vs. +26%, p<0.05. quixil 22-28 interleukin 6 Homo sapiens 189-193 23859389-11 2013 CONCLUSION: Inhalation and intravenous infusion of ketamine before OLV are equally effective in lowering the serum levels of IL-6, IL-8 and sICAM-1. Ketamine 51-59 interleukin 6 Homo sapiens 125-129 22330084-2 2012 Therefore, the current study was designed to investigate the role of IL-6 and IL6 receptors in the cytotoxic effects of zerumbone in ovarian and cervical cancer cell lines (Caov-3 and HeLa, respectively). zerumbone 120-129 interleukin 6 Homo sapiens 69-73 23335506-5 2013 p38 MAPK was activated in endothelial cells upon growth factor stimulation, with inhibition by LY2228820 dimesylate treatment causing a significant decrease in VEGF-, bFGF-, EGF-, and IL-6-induced endothelial cord formation and an even more dramatic decrease in tumor-driven cord formation. ralimetinib 95-104 interleukin 6 Homo sapiens 184-188 22052073-10 2012 Furthermore, 8-OHdG/creatinine correlated with TNF-alpha, sTNF-R1, sTNF-R2 (P < 0.0001), and with IL-6 (P < 0.05). 8-ohdg 13-19 interleukin 6 Homo sapiens 101-105 22330084-2 2012 Therefore, the current study was designed to investigate the role of IL-6 and IL6 receptors in the cytotoxic effects of zerumbone in ovarian and cervical cancer cell lines (Caov-3 and HeLa, respectively). zerumbone 120-129 interleukin 6 Homo sapiens 78-81 22330084-9 2012 However, membrane-bound IL-6 receptor is still intact after zerumbone treatment as demonstrated using an immune-fluorescence technique. zerumbone 60-69 interleukin 6 Homo sapiens 24-28 22539447-11 2013 Significant associations between neopterin and IFN-gamma (r = 0.41, p < 0.0001) and IL-6 (r = 0.35, p = 0.0006) levels were found. Neopterin 33-42 interleukin 6 Homo sapiens 84-88 22330084-10 2012 This study concludes that the compound, zerumbone inhibits both cancer cell growth through the induction of apoptosis, arrests cell cycle at G2/M phase and inhibits the secretion levels of IL-6 in both cancer cells. zerumbone 40-49 interleukin 6 Homo sapiens 189-193 21780211-3 2012 DcE inhibited the production of IL-6, IL-8 and MCP-1 in THP-1 cells and the release of IL-6 and MCP-1 in EoL-1 cells after treatment with house dust mite extract. ethylene dichloride 0-3 interleukin 6 Homo sapiens 87-91 22452847-8 2012 In contrast, dbcAMP significantly increased LPS-induced IL-6, IL-8, and PGE2 production. Bucladesine 13-19 interleukin 6 Homo sapiens 56-60 22315307-8 2012 SkMCs released IL-6, IL-8, and monocyte chemoattractant protein-1 on Hsp60 stimulation. skmcs 0-5 interleukin 6 Homo sapiens 15-19 21835900-8 2012 Treatment with methylprednisolone, compared with placebo, was associated with a statistically significant reduction in plasma IL-6 and IL-8, a significant increase in plasma IL-10, and a significant reduction in postoperative IL-1ra and IL-6, but not IL-8 in BAL fluid obtained 1 day after surgery. Methylprednisolone 15-33 interleukin 6 Homo sapiens 126-130 21835900-8 2012 Treatment with methylprednisolone, compared with placebo, was associated with a statistically significant reduction in plasma IL-6 and IL-8, a significant increase in plasma IL-10, and a significant reduction in postoperative IL-1ra and IL-6, but not IL-8 in BAL fluid obtained 1 day after surgery. Methylprednisolone 15-33 interleukin 6 Homo sapiens 237-241 23527073-10 2013 Clozapine also significantly induced the production of proinflammatory cytokines IL-6, GM-CSF and IL12-p70, and this response was particularly robust in the monocyte cell line. Clozapine 0-9 interleukin 6 Homo sapiens 81-85 22192353-10 2012 Ciglitazone induced IL-6 messenger RNA expression, an effect that was suppressed by GW9662 pretreatment. ciglitazone 0-11 interleukin 6 Homo sapiens 20-24 24204381-5 2013 When co-stimulated with 15d-PGJ2 and activin, 15d-PGJ2 inhibited the activin-induced increases in ActR and Smad expression, and decreased activin-induced IL-6 production. 15-deoxy-delta(12,14)-prostaglandin J2 24-32 interleukin 6 Homo sapiens 154-158 24204381-5 2013 When co-stimulated with 15d-PGJ2 and activin, 15d-PGJ2 inhibited the activin-induced increases in ActR and Smad expression, and decreased activin-induced IL-6 production. 15-deoxy-delta(12,14)-prostaglandin J2 46-54 interleukin 6 Homo sapiens 154-158 22362242-7 2012 It was recently highlighted the role of inflammation and IL-6 in the non-osmotic ADH release. adh 81-84 interleukin 6 Homo sapiens 57-61 21907687-12 2012 Pyridoxamine and aminoguanidine inhibited the endogenous CML formation and the increased RAGE, PAI-1, IL-8, IL-6, and CRP expression. Pyridoxamine 0-12 interleukin 6 Homo sapiens 108-112 24204381-8 2013 These results suggest that 15d-PGJ2 suppresses activin-induced ActR and Smad expression, down-regulates IL-6 production, and up-regulates IL-8 production via suppression of NF- kappa B and MAPK signaling pathway in HepG2 cells. 15-deoxy-delta(12,14)-prostaglandin J2 27-35 interleukin 6 Homo sapiens 104-108 22109853-5 2012 We also demonstrated that tyrosine hydroxylase (TH), the rate-limiting enzyme for synthesis of catecholamine, was reduced after exposure to IL-6, which was accompanied by JAK-STAT3 pathway activation. Catecholamines 95-108 interleukin 6 Homo sapiens 140-144 23045481-9 2012 TcdA/TcdB exposure increased the expression of a number of inflammatory mediators associated with human CDI, including interleukin-6 (IL-6), gamma interferon (IFN-gamma), and IL-1beta. tcda 0-4 interleukin 6 Homo sapiens 119-132 23045481-9 2012 TcdA/TcdB exposure increased the expression of a number of inflammatory mediators associated with human CDI, including interleukin-6 (IL-6), gamma interferon (IFN-gamma), and IL-1beta. tcda 0-4 interleukin 6 Homo sapiens 134-138 21972215-8 2012 The migration distance of BAEC on PU-Au 43.5 ppm was greater than that of HSF, and was significantly reduced by LY294002 or Y-27632 but not SU-1498. Y 27632 124-131 interleukin 6 Homo sapiens 74-77 21088047-11 2012 Inhibition of lipolysis by orlistat or CAY10499 reduced LPS-induced IL-6 and IL-8 mRNA expression. CAY 10499 39-47 interleukin 6 Homo sapiens 68-72 22983102-1 2012 BACKGROUND AND OBJECTIVES: In this study we assesed the effect of a small dose of ketamine on the production of TNFalpha, IL-1beta and IL-6 and the postoperative pain in patients undergoing laparoscopic cholecystectomy. Ketamine 82-90 interleukin 6 Homo sapiens 135-139 22983102-10 2012 CONCLUSIONS: The addition of a small-dose of ketamine in patiens undergoing laparoscopic cholecystectomy resulted in attenuation of secretion of TNFalpha, IL-1beta, IL-6 and reduction of postoperative pain. Ketamine 45-53 interleukin 6 Homo sapiens 165-169 23064268-6 2012 In addition, PGF(2alpha)-stimulated IL-6 release in human osteoblasts was also inhibited by compound C. The IL-6 mRNA expression induced by PGF(2alpha) was markedly reduced by compound C. Downregulation of the AMPK alpha1-subunit by short interfering RNA (siRNA) significantly suppressed the PGF(2alpha)-stimulated IL-6 release. Prostaglandins F 13-16 interleukin 6 Homo sapiens 36-40 23064268-6 2012 In addition, PGF(2alpha)-stimulated IL-6 release in human osteoblasts was also inhibited by compound C. The IL-6 mRNA expression induced by PGF(2alpha) was markedly reduced by compound C. Downregulation of the AMPK alpha1-subunit by short interfering RNA (siRNA) significantly suppressed the PGF(2alpha)-stimulated IL-6 release. Prostaglandins F 140-143 interleukin 6 Homo sapiens 36-40 23064268-6 2012 In addition, PGF(2alpha)-stimulated IL-6 release in human osteoblasts was also inhibited by compound C. The IL-6 mRNA expression induced by PGF(2alpha) was markedly reduced by compound C. Downregulation of the AMPK alpha1-subunit by short interfering RNA (siRNA) significantly suppressed the PGF(2alpha)-stimulated IL-6 release. Prostaglandins F 140-143 interleukin 6 Homo sapiens 36-40 22563483-6 2012 Human PD pathways previously identified by expression analysis, concordant with VMB pathways identified in our study were axonal guidance signaling, Wnt/beta-catenin signaling, IL-6 signaling, ephrin receptor signaling, TGF-beta signaling, PPAR signaling and G-protein coupled receptor signaling. vmb 80-83 interleukin 6 Homo sapiens 177-181 22987052-12 2012 In local circulation, clonidine decreases IL-6 (P = 0.044) but does not influence IL-1beta (P = 0.113). Clonidine 22-31 interleukin 6 Homo sapiens 42-46 23086244-7 2012 Supplement of octreotide also accompanied with reduction in plasma levels of tumor necrosis factor alpha and IL-6. Octreotide 14-24 interleukin 6 Homo sapiens 109-113 21273029-9 2011 The changes in endotoxin obtained by PMX-F treatment were correlated with those in HMGB1, sRAGE, and IL-6. pmx-f 37-42 interleukin 6 Homo sapiens 101-105 21779090-6 2011 However, higher level of PL dairy fatty acids was associated with lower IL-6 among all adolescents. pl dairy fatty acids 25-45 interleukin 6 Homo sapiens 72-76 22005258-7 2011 In addition, CKS decreased UVA-induced expression of the inflammatory cytokines IL-1beta and IL-6. uva 27-30 interleukin 6 Homo sapiens 93-97 21771657-3 2011 In this paper, we discuss the evidence that doxycycline and related non-antibiotic chemically modified tetracyclines (e.g., CMT-3) can effectively reduce cytokine (TNF-alpha, IL-6, and MCP-1) production by human mononuclear inflammatory cells when stimulated either by endotoxin (LPS) or by a complex of C-reactive protein/oxidized LDL cholesterol relevant to the pathogenesis of periodontal disease and ASCVD, respectively. Doxycycline 44-55 interleukin 6 Homo sapiens 175-179 21771657-6 2011 In other studies, a non-antimicrobial formulation of doxycycline (SDD) has been found to dramatically reduce hsCRP, IL-6 and MMP-9 levels in plasma of ACS patients, and SDD has also been found to significantly increase serum levels of both cardio-protective HDL cholesterol and its core molecule apolipoprotein A-I in ASCVD-vulnerable patients with periodontitis. Doxycycline 53-64 interleukin 6 Homo sapiens 116-120 22915474-6 2012 Here, we demonstrate that melamine can activate mitogen-activated protein kinases, NFkappaB, and reactive oxygen species, which results in the upregulation of interleukin-6, monocyte chemoattractant protein-1, vascular cell adhesion molecule-1, and TGF-beta1 in HK-2 cells. melamine 26-34 interleukin 6 Homo sapiens 159-172 22915762-6 2012 cDNA microarray results showed that GD-induced UPR activation promoted upregulation of a number of proangiogenic mediators (VEGF, FGF-2, IL-6, etc.) Gadolinium 36-38 interleukin 6 Homo sapiens 137-141 21784451-6 2011 BMIz was associated with elevated triglycerides (beta = 0.13), CRP (beta = 0.58), and interleukin-6 (beta= 0.14) and low high-density lipoprotein cholesterol (beta = -0.09; all P < .01). bmiz 0-4 interleukin 6 Homo sapiens 86-99 22013115-6 2011 This shift was confined to the SVC fraction, in which secretion of Th1 cytokines (IL-6, MCP-1, and TNF-alpha) was blocked by DHA. Docosahexaenoic Acids 125-128 interleukin 6 Homo sapiens 82-86 22054420-6 2011 The aluminum adjuvant increased the population of both specific ASCs (P < 0.01) and total ASCs(P < 0.05), with a proportional rise in concentrations of CD19+CD27+ (P < 0.05), as well as levels of IL-6, IL-10 (P < 0.05) in splenic lymphocytes. aluminum adjuvant 4-21 interleukin 6 Homo sapiens 205-209 23036591-16 2012 Exposure to BaP affected mo-DC function as demonstrated by decreased IL6 expression induced by PolyI:C, without affecting indoleamine 2,3 dioxygenase (IDO)1 expression. Benzo(a)pyrene 12-15 interleukin 6 Homo sapiens 69-72 22212269-9 2011 Although TNF-alpha and CRP, except for IL-6, showed a tendency to increase in CG, all three tended to decrease in EG after 8 weeks. cysteinylglycine 78-80 interleukin 6 Homo sapiens 39-43 22826531-3 2012 In this systematic review we examined the effect of perioperative ketamine administration on postoperative inflammation as assessed by concentrations of the biomarker interleukin-6 (IL-6). Ketamine 66-74 interleukin 6 Homo sapiens 167-180 22133036-12 2011 Our results were further supported by a negative correlation of methotrexate polyglutamate concentrations and the mRNA expression of the pro-inflammatory cytokines IL-6 and IL-12A. methotrexate polyglutamate 64-90 interleukin 6 Homo sapiens 164-168 22826531-3 2012 In this systematic review we examined the effect of perioperative ketamine administration on postoperative inflammation as assessed by concentrations of the biomarker interleukin-6 (IL-6). Ketamine 66-74 interleukin 6 Homo sapiens 182-186 21796149-3 2011 beta-Glucan stimulation significantly increased IL-8, IL-6, and IL-1alpha production by NHEKs. beta-Glucans 0-11 interleukin 6 Homo sapiens 54-58 21672624-6 2011 Higher adult serum concentrations of interleukin (IL)-6 were associated with lower SES in early childhood (years 1-2) (beta=-.05, p<.05), associations that were independent of adult age, personal income, educational attainment, gender, race, body mass index, and physical activity. Selenium 83-86 interleukin 6 Homo sapiens 37-55 22826531-13 2012 Using postoperative IL-6 concentrations as an outcome, ketamine had an anti-inflammatory effect; the meta-analysis showed a mean preoperative-postoperative IL-6 concentration difference (95% confidence interval) of -71 (-101 to -41) pg/mL. Ketamine 55-63 interleukin 6 Homo sapiens 20-24 22826531-13 2012 Using postoperative IL-6 concentrations as an outcome, ketamine had an anti-inflammatory effect; the meta-analysis showed a mean preoperative-postoperative IL-6 concentration difference (95% confidence interval) of -71 (-101 to -41) pg/mL. Ketamine 55-63 interleukin 6 Homo sapiens 156-160 22826531-14 2012 CONCLUSIONS: It can be concluded that intraoperative administration of ketamine significantly inhibits the early postoperative IL-6 inflammatory response. Ketamine 71-79 interleukin 6 Homo sapiens 127-131 21873375-7 2011 By real-time PCR, we report the first evidences for a DON-induced central inflammation, attested by the strong upregulation of interleukin-1beta, interleukin-6, tumor necrosis factor-alpha, cyclooxygenase-2, and microsomal prostaglandin synthase-1 (mPGES-1) messenger RNA. deoxynivalenol 54-57 interleukin 6 Homo sapiens 146-188 21821055-0 2011 Dimethyl sulphoxide and dimethyl sulphone are potent inhibitors of IL-6 and IL-8 expression in the human chondrocyte cell line C-28/I2. Dimethyl Sulfoxide 0-19 interleukin 6 Homo sapiens 67-71 23006534-9 2012 RESULTS: Incubation with LPS, LTA or TCS significantly increased TNF-alpha, IL-1beta, IL-6, IL-8, IFN-gamma and IL-2 in comparison to incubation with RPMI alone. Technetium 37-40 interleukin 6 Homo sapiens 86-90 21821055-2 2011 Since thiols could be potent inhibitors of the production of cytokines, the effects of dimethyl sulphoxide (DMSO) and dimethyl sulphone (DMS) on constitutive and IL-1beta-induced IL-6 and IL-8 expression in the human chondrocyte cell line C-28/I2 were evaluated. Dimethyl Sulfoxide 87-106 interleukin 6 Homo sapiens 179-183 23023382-6 2012 RESULTS: BSO and NAC significantly decreased IL-6 and TNF-alpha levels at 14 days of differentiation, whereas, NAC decreased the levels of IL-8 at days 2 and 14 of differentiation. nac 17-20 interleukin 6 Homo sapiens 45-49 21930594-5 2011 Moreover, we found that loratadine and chlorpromazine, histamine 1 receptor (H1R) antagonists, more effectively impair the production of LPS-induced IL-6 than that of other inflammatory cytokines in Ahr(-/-) macrophages. Loratadine 24-34 interleukin 6 Homo sapiens 149-153 21934447-6 2011 Poly (inosinic acid:cytidylic acid) by itself stimulated the release of IL-6 (305 pg/mL) and enhanced IL-8 production (2.8 ng/mL). Cytidine Monophosphate 20-34 interleukin 6 Homo sapiens 72-76 21821055-8 2011 Long-term exposure of cells to DMSO (1%) or DMS (100mM) led to a dramatic downregulation of IL-6 and IL-8 expression which was accompanied by the deactivation of ERK1/2. Dimethyl Sulfoxide 31-35 interleukin 6 Homo sapiens 92-96 21821055-10 2011 SIGNIFICANCE: In this study, we demonstrate that both DMSO and DMS represent strong anti-inflammatory properties by blocking constitutive as well as IL-1beta-induced IL-6 and IL-8 expression in the human chondrocyte cell line C-28/I2. Dimethyl Sulfoxide 54-58 interleukin 6 Homo sapiens 166-170 21420233-6 2011 This results in combinatorial inhibition of NFkappaB activity by gallic acid, which results in potent inhibition of NFkappaB target genes involved in inflammation, metastasis, anti-apoptosis and angiogenesis, such as IL-6, IL-8, COX2, CXCR4, XIAP, bcl2, VEGF. Gallic Acid 65-76 interleukin 6 Homo sapiens 217-221 21643893-5 2011 After the inflammatory human bronchial epithelial cell line BEAS-2B was treated with dehydroepiandrosterone, levels of proinflammatory cytokines and chemokines were inhibited, including IL-6, IL-8, CCL11, and CCL24. Dehydroepiandrosterone 85-107 interleukin 6 Homo sapiens 186-190 22137266-9 2012 Co-culture of DHA-enriched macrophages with adipocytes attenuated IL-6 and TNFalpha secretion while enhancing IL-10 secretion. Docosahexaenoic Acids 14-17 interleukin 6 Homo sapiens 66-70 20946124-9 2011 BK-induced release of IL-6, but not of IL-8, was partially inhibited by indomethacin (10 microM) and nordihydroguaiaretic acid (10 microM). Indomethacin 72-84 interleukin 6 Homo sapiens 22-26 22733812-5 2012 We show that DMF inhibits DC maturation by reducing inflammatory cytokine production (IL-12 and IL-6) and the expression of MHC class II, CD80, and CD86. Dimethyl Fumarate 13-16 interleukin 6 Homo sapiens 96-100 21111593-7 2011 Whereas stigmasterol blunted aggregated LDL (agLDL) induced increases in tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-1beta secretion, sitosterol exacerbated these effects. agldl 45-50 interleukin 6 Homo sapiens 108-126 21365246-7 2011 The activation of FUT1, FUT2 and FUT4 by IL-1beta is through the NF-kappaB pathway and the down-regulation of FUT3 and FUT5 by IL-6 is through the gp130/STAT-3 pathway, since they are inhibited specifically by panepoxydone and AG490, respectively. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 227-232 interleukin 6 Homo sapiens 127-131 21752263-11 2011 Following FcgammaR stimulation, PCI-32765 inhibited TNFalpha, IL-1beta and IL-6 production in primary monocytes (IC(50) = 2.6, 0.5, 3.9 nM, respectively). ibrutinib 32-41 interleukin 6 Homo sapiens 75-79 22170858-3 2012 The triterpene acid mixture inhibited the production of tumor necrosis factor-alpha and IL-6 with estimated IC50 values in the range 35-56 microg/mL, the Th1 cytokines interferon-gamma and IL-2 (IC50 values 10-20 microg/mL) and the antiinflammatory cytokine IL-10 (IC50 values 18-21 microg/mL). triterpene acid 4-19 interleukin 6 Homo sapiens 88-92 21461372-3 2011 In this study, we evaluated the effectiveness of doxycycline and tetracycline to modulate serum levels of IL-6, IL-1B, and TNF and cytokine receptor/receptor antagonist TNF-R1 and IL-1RA in patients with DF or DHF. Tetracycline 65-77 interleukin 6 Homo sapiens 106-110 22592163-12 2012 Chelerythrine decreased the level of IL-6 mRNA by a factor of 1.6 (p<0.001). chelerythrine 0-13 interleukin 6 Homo sapiens 37-41 22343219-3 2012 In the present study, we demonstrate that cell-surface beta-glucan components of Pneumocystis (PCBG) stimulate human dendritic cells (DCs) to secrete IL-23 and IL-6. beta-Glucans 55-66 interleukin 6 Homo sapiens 160-164 21586579-0 2011 IL-6-independent association of elevated serum neopterin levels with prevalent frailty in community-dwelling older adults. Neopterin 47-56 interleukin 6 Homo sapiens 0-4 21586579-4 2011 The objective of this study was to evaluate IL-6-independent association of serum neopterin levels with prevalent frailty. Neopterin 82-91 interleukin 6 Homo sapiens 44-48 21586579-8 2011 Pearson correlation and multivariate linear regression analysis was performed to assess the relationship between log(neopterin) and log(IL-6). Neopterin 117-126 interleukin 6 Homo sapiens 136-140 21586579-15 2011 Log(neopterin) correlated with log(IL-6) (correlation coefficient = 0.19, P < 0.05). Neopterin 4-13 interleukin 6 Homo sapiens 35-39 23798918-1 2012 BACKGROUND: This study aimed to investigate whether magnesium supplementation might affect serum magnesium, high sensitive C-reactive protein (hs-CRP), plasma fibrinogen, and interleukin 6 (IL-6) levels in healthy middle-aged overweight women. Magnesium 52-61 interleukin 6 Homo sapiens 175-188 20861644-9 2011 PGN- and Pam(3)CSK(4)-induced mast cell IL-6, but not IL-1beta, production was dependent on adenylyl cyclase activity and could be partially inhibited by the cyclooxygenase inhibitor naproxen. Naproxen 183-191 interleukin 6 Homo sapiens 40-44 23798918-1 2012 BACKGROUND: This study aimed to investigate whether magnesium supplementation might affect serum magnesium, high sensitive C-reactive protein (hs-CRP), plasma fibrinogen, and interleukin 6 (IL-6) levels in healthy middle-aged overweight women. Magnesium 52-61 interleukin 6 Homo sapiens 190-194 23798918-9 2012 Mean concentration of IL-6 was significantly increased in the magnesium group comparing the baseline value(P=0.001). Magnesium 62-71 interleukin 6 Homo sapiens 22-26 21586579-16 2011 Moreover, OR for participants in the top neopterin tertile remained significant after adjusting for IL-6 (OR = 3.97, 95% CI = 1.15-13.72, P < 0.05). Neopterin 41-50 interleukin 6 Homo sapiens 100-104 21586579-17 2011 CONCLUSION: elevated neopterin levels had IL-6-independent association with prevalent frailty, suggesting potential monocyte/macrophage-mediated immune activation in the frail elderly. Neopterin 21-30 interleukin 6 Homo sapiens 42-46 22577451-6 2011 RESULTS: Dietary intakes of "choline"/"choline and betaine" were not significantly associated with CVD risk; however, the higher intakes of choline and betaine were associated with higher serum concentrations of CRP, IL-6 and TNF-alpha. Betaine 152-159 interleukin 6 Homo sapiens 217-221 26105220-1 2012 Treatment with magnesium sulphate reduced the serum level of IL-6in preeclamptic women. Magnesium Sulfate 15-33 interleukin 6 Homo sapiens 61-65 21139503-0 2011 Effects of magnetic resonance imaging contrast agents on human umbilical vein endothelial cells and evaluation of magnetic resonance imaging contrast media-triggered transforming growth factor-beta induction in dermal fibroblasts (HSF) as a model for nephrogenic systemic fibrosis. magnetic resonance imaging contrast media 114-155 interleukin 6 Homo sapiens 231-234 26105220-5 2012 OBJECTIVES: Although a RCT compared magnesium supplementation with placebo suggested there is no effect on the incidence of preeclampsia, a study showed treatment with MgSO4 reduced the level of IL-6 secretion in maternal circulation of preeclamptic placenta not fetal side [1]. Magnesium Sulfate 168-173 interleukin 6 Homo sapiens 195-199 26105220-6 2012 In addition, a most recent study suggests that treatment with MgSO4 inhibited inflammatory cytokines such as IL-6 secretion induced by LPS [2]. Magnesium Sulfate 62-67 interleukin 6 Homo sapiens 109-113 26105220-7 2012 Taken together these data suggest MgSO4 may be able to normalise IL-6 actions and secretion. Magnesium Sulfate 34-39 interleukin 6 Homo sapiens 65-69 26105220-8 2012 IL-6 level is elevated in preeclamtic women, therefore in this study we investigated whether maternal MgSO4 treatment inhibit IL-6 secretion in women with preeclampsia. Magnesium Sulfate 102-107 interleukin 6 Homo sapiens 0-4 26105220-8 2012 IL-6 level is elevated in preeclamtic women, therefore in this study we investigated whether maternal MgSO4 treatment inhibit IL-6 secretion in women with preeclampsia. Magnesium Sulfate 102-107 interleukin 6 Homo sapiens 126-130 26105220-13 2012 RESULTS: The serum level of IL-6 in preeclamptic women (24.59pg/ml) was significantly increased before MgSO4 administration compared to gestation matched health pregnant women (11.1pg/ml). Magnesium Sulfate 103-108 interleukin 6 Homo sapiens 28-32 26105220-14 2012 However the serum level of IL-6 was significantly reduced after MgSO4 administration (19.8pg/ml), but sill higher than gestation matched health pregnant women. Magnesium Sulfate 64-69 interleukin 6 Homo sapiens 27-31 26105220-15 2012 CONCLUSION: Although the mechanism of magnesium sulphate is incompletely understood, our date consist with recent findings and suggest that it may act through the regulation of the level of IL-6 secretion which plays an important role in the pathogenesis of preeclampsia. Magnesium Sulfate 38-56 interleukin 6 Homo sapiens 190-194 21733822-7 2011 Celecoxib significantly reduced plasma c-reactive protein and interleukin-6 mRNA and protein and increased 15(S)-hydroxy-eicosatetraenoic acid levels in bronchoalveolar lavage (BAL) samples. Celecoxib 0-9 interleukin 6 Homo sapiens 62-75 21262066-8 2011 On day 60, urinary iodine correlated with C-reactive protein (r 0 461, P = 0 018), and free triiodothyronine correlated with IL-6 (r - 0 429, P = 0 025). Triiodothyronine 92-108 interleukin 6 Homo sapiens 125-129 22121382-8 2011 Salmeterol increased, while dexamethasone and fluticasone decreased RV-induced IL-6 and IL-8 (P<0.05). Fluticasone 46-57 interleukin 6 Homo sapiens 79-83 21181220-14 2011 Significant positive correlation was observed between IL-17 and IL-1beta (r = 0.38, p < 0.005), IL-17 and IL-6 (r = 0.659, p < 0.0001), and IL-1beta and IL-6 (r = 0.391, p < 0.0001) in ReA and uSpA group. uspa 202-206 interleukin 6 Homo sapiens 109-113 22664467-3 2012 We have reported that low doses of ketamine administrated to patients before incision significantly reduced post-operative inflammation as reflected by reduced interleukin-6 (IL-6) sera-levels. Ketamine 35-43 interleukin 6 Homo sapiens 160-173 21042414-1 2010 5-Androstene-3beta,7beta,17beta-triol (beta-AET), an active metabolite of dehydroepiandrosterone (DHEA), reversed glucocorticoid (GC)-induced suppression of IL-6, IL-8 and osteoprotegerin production by human osteoblast-like MG-63 cells and promoted osteoblast differentiation of human mesenchymal stem cells (MSCs). 5-androstene-3,7,17-triol 39-47 interleukin 6 Homo sapiens 157-161 22664467-3 2012 We have reported that low doses of ketamine administrated to patients before incision significantly reduced post-operative inflammation as reflected by reduced interleukin-6 (IL-6) sera-levels. Ketamine 35-43 interleukin 6 Homo sapiens 175-179 22664467-5 2012 Similar to what we have observed in operated patients, the levels of TNF-alpha and IL-6 in ketamine-treated rats were significantly lower than in septic animals not treated with ketamine. Ketamine 91-99 interleukin 6 Homo sapiens 83-87 21605007-5 2011 Following ozone exposure, these purines remained correlated with IL-6, IL-8, and TNF-alpha (r = 0.37-0.68). Purines 32-39 interleukin 6 Homo sapiens 65-69 20698827-5 2010 Interestingly, exposure of DS-HSF to dibutyryl-cAMP, a permanent derivative of cAMP, stimulated ANT, AK and ATPase activities, whereas H89, a specific PKA (protein kinase A) inhibitor, suppressed this cAMPdependent activation, indicating an involvement of the cAMP/PKA-mediated signalling pathway in the ATPase, ANT and AK deficit. Bucladesine 37-51 interleukin 6 Homo sapiens 30-33 20880395-5 2010 KEY RESULTS: We found that TQ inhibited both constitutive and IL-6-inducible STAT3 phosphorylation which correlated with the inhibition of c-Src and JAK2 activation. thymoquinone 27-29 interleukin 6 Homo sapiens 62-66 21397587-7 2011 We found that celecoxib inhibits IL-6-induced and persistent STAT3 phosphorylation and inhibits cell viability in human rhabdomyosarcoma cells. Celecoxib 14-23 interleukin 6 Homo sapiens 33-37 21674161-7 2012 Peptides 34059, 34060, 34295 and 34297 induced IL-6 levels in PBMCs (EC50=3.4, 3.3, 0.5, 0.5 muM, respectively) at higher potency than peptide 11389 (EC50=5.8 muM). Peptides 0-8 interleukin 6 Homo sapiens 47-51 20223497-6 2010 RESULTS: Administration of taurolidine in crystalloid cardioplegia patients resulted in a significant decrease in serum IL-6 and an increase in serum IL-10 at 24 hours postaortic unclamping compared to placebo (P < .0001). taurolidine 27-38 interleukin 6 Homo sapiens 120-124 22499992-6 2012 In monocytic cell line induced by phorbol 12-myristate 13-acetate or ex vivo culture obtained from human aneurysmal tissues, 2-deoxyglucose abrogated the matrix metalloproteinase-9 activity and interleukin-6 expression in these cells/tissues. Deoxyglucose 125-139 interleukin 6 Homo sapiens 194-207 22345573-5 2012 Rho kinase inhibitor Y-27632 suppressed the synergistic effect of 18% CS on IL-6-induced EC monolayer disruption but did not alter the IL-6 effects on static EC culture. Y 27632 21-28 interleukin 6 Homo sapiens 76-80 21321193-4 2011 We also demonstrate that interleukin 6 (IL-6), shown to be increased in NMO, enhanced the survival of PB as well as their AQP4-Ab secretion, whereas the blockade of IL-6 receptor (IL-6R) signaling by anti-IL-6R antibody reduced the survival of PB in vitro. pladienolide B 102-104 interleukin 6 Homo sapiens 25-38 21321193-4 2011 We also demonstrate that interleukin 6 (IL-6), shown to be increased in NMO, enhanced the survival of PB as well as their AQP4-Ab secretion, whereas the blockade of IL-6 receptor (IL-6R) signaling by anti-IL-6R antibody reduced the survival of PB in vitro. pladienolide B 102-104 interleukin 6 Homo sapiens 40-44 21321193-4 2011 We also demonstrate that interleukin 6 (IL-6), shown to be increased in NMO, enhanced the survival of PB as well as their AQP4-Ab secretion, whereas the blockade of IL-6 receptor (IL-6R) signaling by anti-IL-6R antibody reduced the survival of PB in vitro. pladienolide B 244-246 interleukin 6 Homo sapiens 25-38 21321193-4 2011 We also demonstrate that interleukin 6 (IL-6), shown to be increased in NMO, enhanced the survival of PB as well as their AQP4-Ab secretion, whereas the blockade of IL-6 receptor (IL-6R) signaling by anti-IL-6R antibody reduced the survival of PB in vitro. pladienolide B 244-246 interleukin 6 Homo sapiens 40-44 22345573-6 2012 18% CS also increased IL-6-induced ICAM-1 expression by pulmonary EC and neutrophil adhesion, which was attenuated by Y-27632. Y 27632 118-125 interleukin 6 Homo sapiens 22-26 22345573-9 2012 Intravenous injection of Y-27632 suppressed IL6/HTV-induced lung injury. Y 27632 25-32 interleukin 6 Homo sapiens 44-47 20592333-10 2010 Multivariate regression analysis, including sex, age, body mass index, hypercholesterolaemia, smoking, hypertension diabetes, identified CG + CC genotype as the only independent predictor of preoperative CRP and IL-6 levels. cysteinylglycine 137-139 interleukin 6 Homo sapiens 212-216 22415150-0 2012 Elevated tear interleukin-6 and interleukin-8 levels associated with silicone hydrogel and conventional hydrogel contact lens wear. Silicones 69-77 interleukin 6 Homo sapiens 14-27 21352574-9 2011 The combination of 10(-5) M desloratadine and 10(-9) M mometasone reduced IL-6 secretion (48 +- 11%, p < 0.05) greater extent than mometasone alone (68 +- 10%) compared to control (100%). Mometasone Furoate 55-65 interleukin 6 Homo sapiens 74-78 20047993-4 2010 Indoxyl sulfate stimulated tumour necrosis factor-alpha, interleukin-6 (IL-6), and IL-1beta mRNA expression in THP-1 cells as quantified by RT-PCR. Indican 0-15 interleukin 6 Homo sapiens 57-70 21257314-7 2011 This is the first report of the inhibitory activity of endogenous fatty acid amides and their analogues on the production of nitric oxide, cytokines (IL-1beta, IL-6, and TNF-alpha) and the chemokine MDC. Amides 77-83 interleukin 6 Homo sapiens 160-164 20880729-8 2011 Ezetimibe was associated with a significant reduction in aortic wall MMP-9 (p = 0.02) and aortic wall IL-6 (p = 0.02), associated with a reduction in plasma lipids. Ezetimibe 0-9 interleukin 6 Homo sapiens 102-106 21968012-0 2012 Pentoxifylline decreases serum levels of tumor necrosis factor alpha, interleukin 6 and C-reactive protein in hemodialysis patients: results of a randomized double-blind, controlled clinical trial. Pentoxifylline 0-14 interleukin 6 Homo sapiens 70-83 21968012-6 2012 CONCLUSIONS: Pentoxifylline significantly decreased serum concentrations of TNF-alpha, IL-6 and CRP compared to placebo. Pentoxifylline 13-27 interleukin 6 Homo sapiens 87-91 22182511-3 2012 Comparison of two MEK inhibitors, the specific, widely used U0126 and the more selective PD0325901, in different MC models revealed severe differences on SF-induced expression of proinflammatory cytokines IL-6 and TNF-alpha as well as the transcription factor Kruppel-like factor 2 (KLF2). mirdametinib 89-98 interleukin 6 Homo sapiens 205-209 20047993-4 2010 Indoxyl sulfate stimulated tumour necrosis factor-alpha, interleukin-6 (IL-6), and IL-1beta mRNA expression in THP-1 cells as quantified by RT-PCR. Indican 0-15 interleukin 6 Homo sapiens 72-76 21224438-5 2011 The release of proinflammatory cytokines (tumor necrosis factor alpha, interleukin-6, and interleukin-8) was reduced by 1:1 and 1:2 DHA/AA ratios (P < .01 to P < .001) but increased by 1:4 and 1:7 DHA/AA ratios (P < .01 to P < .001) vs control. Docosahexaenoic Acids 132-135 interleukin 6 Homo sapiens 71-84 22531121-7 2011 The concentrations of IL-6, IL-8, VEGF and MMP-2 protein in the culture supernatant of MKN-45P were significantly higher than those of MKN-45. mkn-45 87-93 interleukin 6 Homo sapiens 22-26 20044210-4 2010 Catecholamines and cortisol in plasma and lipopolysaccharide (LPS) stimulated levels of TNF-alpha and IL-6 by peripheral leucocytes were assessed along with severity of obsessive-compulsive symptoms, disgust, and anxiety levels using Visual Analogue Scales prior, during and after a provocation paradigm. Catecholamines 0-14 interleukin 6 Homo sapiens 102-106 21921982-4 2011 We have previously shown that cis-UCA can suppress UV-B-induced interleukin-6 and -8 secretion and cytotoxicity in human corneal epithelium (HCE) cells. cis-Urocanic acid 30-37 interleukin 6 Homo sapiens 64-84 22781322-17 2012 Serum content of IL-6 of patients in SS group decreased gradually from PBD 13, but that in SD group increased continuously at the same time points. H-SER-SER-OH 37-39 interleukin 6 Homo sapiens 17-21 22781322-19 2012 Serum contents of IL-6 of patients in SS group [(300 +- 33) pg/mL on PBD 13] were obviously lower than those in SD group [(338 +- 22) pg/mL on PBD 13, q test, P < 0.05] from PBD 13. H-SER-SER-OH 38-40 interleukin 6 Homo sapiens 18-22 20108153-11 2010 Subgroup comparisons showed significantly higher levels of TNF-alpha and IL-6 with NOTES-CO(2) than with LX-AIR on POD 1 (p = 0.022) and POD 2 (p = 0.002). Carbon Dioxide 89-94 interleukin 6 Homo sapiens 73-77 22414048-8 2012 RESULTS: Multiple inflammatory mediators were inhibited by methoxyphenols, including: CCL2, CCL5, IL-6, IL-8, ICAM-1, MIF, CXCL1, CXCL10, and Serpin E1. Guaiacol 59-73 interleukin 6 Homo sapiens 98-102 20921085-4 2011 IL-6 was higher in the statin-treated patients (p<0.05 versus methylprednisolone). Methylprednisolone 65-83 interleukin 6 Homo sapiens 0-4 20484173-5 2010 Intake of flavonols, especially of isorhamnetin, kaempferol, and quercetin, was inversely associated with serum IL-6 concentrations (highest versus lowest flavonol intake quartile, 1.80 versus 2.20 pg/mL) and high-risk (OR, 0.51; 95% CI, 0.26-0.98) and advanced adenoma recurrence (OR, 0.17; 95% CI, 0.06-0.50). 3-methylquercetin 35-47 interleukin 6 Homo sapiens 112-116 22125636-6 2011 In PBMC from healthy donors, budesonide alone inhibited IP-10 and IL-6 production induced by imiquimod in a concentration-dependent manner and the degree of inhibition was amplified when budesonide and formoterol were used in combination. Budesonide 29-39 interleukin 6 Homo sapiens 66-70 20712259-15 2010 CONCLUSION: Obese women with a low PA tertile have high fat mass with a secondary high level of glucose, HOMA, IL-6 and leptin. Protactinium 35-37 interleukin 6 Homo sapiens 111-115 22125636-6 2011 In PBMC from healthy donors, budesonide alone inhibited IP-10 and IL-6 production induced by imiquimod in a concentration-dependent manner and the degree of inhibition was amplified when budesonide and formoterol were used in combination. Budesonide 187-197 interleukin 6 Homo sapiens 66-70 21779360-4 2011 Our findings showed that pretreatment of HaCaT cells with NaHS (a donor of H(2)S) for 30 min before exposure to CoCl(2) for 24 h significantly attenuated CoCl(2)-induced injuries and inflammatory responses, evidenced by increases in cell viability and GSH level and decreases in ROS generation and secretions of IL-1beta, IL-6 and IL-8. Hydrogen Sulfide 75-80 interleukin 6 Homo sapiens 322-326 20507639-1 2010 BACKGROUND: Our previous study showed that, in basal cell carcinoma cells, arecoline reduces levels of the tumor cell survival factor interleukin-6 (IL-6), increases levels of tumor suppressor factor p53, and elicits cell cycle arrest, followed by apoptosis. Arecoline 75-84 interleukin 6 Homo sapiens 134-147 21136335-0 2010 Inhibition of NF-kappaB and AP-1 by dimethylfumarate correlates with down-regulated IL-6 secretion and proliferation in human lung fibroblasts. Dimethyl Fumarate 36-52 interleukin 6 Homo sapiens 84-88 21136335-10 2010 PDGF-BB and TNF-alpha induced IL-6 secretion by lung fibroblasts and this was inhibited by DMF in a dose-dependent manner. Dimethyl Fumarate 91-94 interleukin 6 Homo sapiens 30-34 21136335-14 2010 CONCLUSIONS: Our data suggest that DMF down-regulates TNF-alpha-induced IL-6 secretion and proliferation by inhibiting NF-kB and AP-1 activity, indicating its potential beneficial use for the treatment of inflammatory lung diseases. Dimethyl Fumarate 35-38 interleukin 6 Homo sapiens 72-76 20507639-1 2010 BACKGROUND: Our previous study showed that, in basal cell carcinoma cells, arecoline reduces levels of the tumor cell survival factor interleukin-6 (IL-6), increases levels of tumor suppressor factor p53, and elicits cell cycle arrest, followed by apoptosis. Arecoline 75-84 interleukin 6 Homo sapiens 149-153 20414027-10 2010 In this case, vitamin B6 seemed to be effective to control HSF and allow continuation of capecitabine + docetaxel combination therapy. Vitamin B 6 14-24 interleukin 6 Homo sapiens 59-62 20827028-6 2010 Serum tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and monocyte chemoattractant protein (MCP)-1 levels were significantly decreased with losartan (P<0.05). Losartan 147-155 interleukin 6 Homo sapiens 41-59 20130114-10 2010 In human adipocytes isolated from noninflamed adipose tissue, LPS and Pam(3)Cys, but not MALP-2, are potent inducers of IL-6 and MCP-1. (3)cys 73-79 interleukin 6 Homo sapiens 120-124 20725963-4 2010 We demonstrate herein that a commercially available analogue of these amphiphilic siloxane species, the rake copolymer GP226, decreases collagen synthesis on exposure to cultures of fibroblasts derived from HSF. Siloxanes 82-90 interleukin 6 Homo sapiens 207-210 20004742-5 2010 While inhibition of the expression of the TNF-alpha gene was mediated predominantly by the alpha-bungarotoxin sensitive nAChRs, that of the IL-6 and IL-18 genes-by the mecamylamine-sensitive nAChRs. Mecamylamine 168-180 interleukin 6 Homo sapiens 140-144 20961405-3 2010 Earlier we reported that Dimethylfumarate (DMF) inhibits platelet-derived growth factor (PDGF)-BB induced mitogen and stress activated kinase (MSK)-1 and CREB activity as well as IL-6 secretion by ASMC. Dimethyl Fumarate 25-41 interleukin 6 Homo sapiens 179-183 20961405-3 2010 Earlier we reported that Dimethylfumarate (DMF) inhibits platelet-derived growth factor (PDGF)-BB induced mitogen and stress activated kinase (MSK)-1 and CREB activity as well as IL-6 secretion by ASMC. Dimethyl Fumarate 43-46 interleukin 6 Homo sapiens 179-183 20601112-6 2010 DHEA and EPEA were found to decrease LPS induced adipocyte IL-6 and MCP-1 levels. Dehydroepiandrosterone 0-4 interleukin 6 Homo sapiens 59-63 19506792-7 2010 After adjusting for age, the IL6 -634G > C (rs1800796) allele showed association with osteoporosis (odds ratio (OR) for CC + CG = 2.51, p = 0.0047)), independent of statin use or smoking status. cysteinylglycine 128-130 interleukin 6 Homo sapiens 29-32 20601112-7 2010 Results of combined incubations with PPAR-gamma and CB2 antagonists suggest a role of these receptors in mediating the reduction of IL-6 by DHEA. Dehydroepiandrosterone 140-144 interleukin 6 Homo sapiens 132-136 20961828-5 2010 RESULTS: Compared with the control group, the IT group had smaller increases in plasma concentrations of tumor necrosis factor alpha, interleukin 1beta (IL-1beta), IL-6, and cTnI, and had a more pronounced increase in IL-10 levels after the initiation of CPB. Isoleucyl-Threonine 46-48 interleukin 6 Homo sapiens 164-168 19647363-7 2010 Treatment of the cells with curcumin inhibited LPA-induced IL-6 and IL-8 secretion and STAT3 phosphorylation, leading to blocked ovarian cancer cell motility. lysophosphatidic acid 47-50 interleukin 6 Homo sapiens 59-63 20814329-0 2010 Clozapine mobilizes CD34+ hematopoietic stem and progenitor cells and increases plasma concentration of interleukin 6 in patients with schizophrenia. Clozapine 0-9 interleukin 6 Homo sapiens 104-117 20814329-5 2010 A transversal investigation of 12 clozapine-monotreated long-term patients and 10 controls revealed a 1.3-fold elevation of plasma interleukin 6 levels in patients on clozapine (P = 0.017). Clozapine 34-43 interleukin 6 Homo sapiens 131-144 20814329-5 2010 A transversal investigation of 12 clozapine-monotreated long-term patients and 10 controls revealed a 1.3-fold elevation of plasma interleukin 6 levels in patients on clozapine (P = 0.017). Clozapine 167-176 interleukin 6 Homo sapiens 131-144 20000589-3 2010 Screening of indole metabolites has identified indoxyl 3-sulfate (I3S) as a potent endogenous ligand that selectively activates the human AHR at nanomolar concentrations in primary human hepatocytes, regulating transcription of multiple genes, including CYP1A1, CYP1A2, CYP1B1, UGT1A1, UGT1A6, IL6, and SAA1. indoxyl 3-sulfate 47-64 interleukin 6 Homo sapiens 294-297 20814329-6 2010 In conclusion, clozapine treatment results in an initial mobilization of CD34(+) stem and progenitor cells into the peripheral blood and in a slight long-term elevation of interleukin 6. Clozapine 15-24 interleukin 6 Homo sapiens 172-185 20040350-15 2010 HD patients with the HADS-A positive for anxiety showed higher IL-6 production (p = 0.026), while IL-1beta levels were not associated with symptoms of depression. hads-a 21-27 interleukin 6 Homo sapiens 63-67 20799759-7 2010 As a phosphodiesterase inhibitor, pentoxifylline downregulates pro-inflammatory cytokines such as tumor necrosis factor-alpha, interleukin-6, and interferon-gamma. Pentoxifylline 34-48 interleukin 6 Homo sapiens 127-140 20379953-4 2010 These results suggest that blocking of IL-6-induced signal transduction is partially due to the sustained activation of ERK1/2 by kansuinine A and B, which in turn results in an increase of Stat3 serine phosphorylation and SOCS-3 expression. kansuinine a and b 130-148 interleukin 6 Homo sapiens 39-43 20379953-5 2010 Treatment with kansuinine A and B represents a novel method to block these IL-6-induced effects. kansuinine a and b 15-33 interleukin 6 Homo sapiens 75-79 19805306-0 2009 aPKClambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6. iota 11-15 interleukin 6 Homo sapiens 118-131 20416859-10 2010 Anti-IL6 seem to increase total and LDL-cholesterol; however these changes are associated with an improvement in the TC/HDL-C ratio. Technetium 117-119 interleukin 6 Homo sapiens 5-8 19805306-8 2009 We conclude that aPKClambda/iota promotes the growth of hormone independent prostate cancer cells by stimulating IL-6 production in an autocrine manner. iota 28-32 interleukin 6 Homo sapiens 113-117 19723085-6 2009 We found that omega-3 fatty acids, such as docosahexaenoic acid (DHA) and alpha-linolenic acid (ALA), suppressed the expression of inflammatory cytokines (IL-1beta, IL-6) and inhibited the activation of transcription factor activator protein-1 in cerulein-stimulated pancreatic acinar cells. alpha-Linolenic Acid 74-94 interleukin 6 Homo sapiens 165-169 21442031-0 2010 Andrographolide, an herbal medicine, inhibits interleukin-6 expression and suppresses prostate cancer cell growth. andrographolide 0-15 interleukin 6 Homo sapiens 46-59 21442031-2 2010 Through drug screening using human prostate cancer cells expressing IL-6 autocrine loop, we found that andrographolide, a diterpenoid lactone isolated from a traditional Chinese and Indian medicinal plant Andrographis paniculata, could inhibit IL-6 expression and suppress IL-6-mediated signals. andrographolide 103-118 interleukin 6 Homo sapiens 68-72 21442031-2 2010 Through drug screening using human prostate cancer cells expressing IL-6 autocrine loop, we found that andrographolide, a diterpenoid lactone isolated from a traditional Chinese and Indian medicinal plant Andrographis paniculata, could inhibit IL-6 expression and suppress IL-6-mediated signals. andrographolide 103-118 interleukin 6 Homo sapiens 244-248 19723085-6 2009 We found that omega-3 fatty acids, such as docosahexaenoic acid (DHA) and alpha-linolenic acid (ALA), suppressed the expression of inflammatory cytokines (IL-1beta, IL-6) and inhibited the activation of transcription factor activator protein-1 in cerulein-stimulated pancreatic acinar cells. alpha-Linolenic Acid 96-99 interleukin 6 Homo sapiens 165-169 21442031-2 2010 Through drug screening using human prostate cancer cells expressing IL-6 autocrine loop, we found that andrographolide, a diterpenoid lactone isolated from a traditional Chinese and Indian medicinal plant Andrographis paniculata, could inhibit IL-6 expression and suppress IL-6-mediated signals. andrographolide 103-118 interleukin 6 Homo sapiens 244-248 21442031-3 2010 Andrographolide inhibits IL-6 expression at both mRNA and protein levels in a dose-dependent manner. andrographolide 0-15 interleukin 6 Homo sapiens 25-29 19635391-4 2009 Exposure of BE(2)-C cells to the heavy metals CdCl(2) and HgCl(2) and to the mitochondrial complex I inhibitor rotenone inhibited interleukin-6, interferon-gamma and ciliary neurotrophic factor-mediated Jak/STAT signaling, reduced Jak1 and Jak2 auto-phosphorylation and induced Jak tyrosine nitration. Rotenone 111-119 interleukin 6 Homo sapiens 130-143 21442031-4 2010 Andrographolide suppresses both IL-6 autocrine loop- and paracrine loop-induced cell signaling including Stat3 and Erk phosphorylation. andrographolide 0-15 interleukin 6 Homo sapiens 32-36 21442031-6 2010 Moreover, treatment of andrographolide to mice bearing castration-resistant DU145 human prostate tumors that express constitutive IL-6 autocrine loop significantly suppresses tumor growth. andrographolide 23-38 interleukin 6 Homo sapiens 130-134 21442031-7 2010 Taken together, these results demonstrate that andrographolide could be developed as a therapeutic agent to treat both androgen-stimulated and castration-resistant prostate cancer possibly by suppressing IL-6 expression and IL-6-induced signaling. andrographolide 47-62 interleukin 6 Homo sapiens 204-208 21442031-7 2010 Taken together, these results demonstrate that andrographolide could be developed as a therapeutic agent to treat both androgen-stimulated and castration-resistant prostate cancer possibly by suppressing IL-6 expression and IL-6-induced signaling. andrographolide 47-62 interleukin 6 Homo sapiens 224-228 20307681-4 2010 Formoterol enhanced and budesonide inhibited IL-6, CXCL8 and CXCL1 release from LPS-stimulated neutrophils. Budesonide 24-34 interleukin 6 Homo sapiens 45-49 19483309-4 2009 In the present study, we investigate the effect of Columbianetin on the production of histamine, interleukin (IL)-1beta, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha and expression of cyclooxygenase-2 (COX-2) by using the human mast cell line (HMC-1). columbianetin 51-64 interleukin 6 Homo sapiens 121-125 20461739-0 2010 Tea polyphenols inhibit IL-6 production in tumor necrosis factor superfamily 14-stimulated human gingival fibroblasts. Polyphenols 4-15 interleukin 6 Homo sapiens 24-28 19328000-0 2009 Structural-activity relationship study of highly-functionalized imidazolines as potent inhibitors of nuclear transcription factor-kappaB mediated IL-6 production. Imidazolines 64-76 interleukin 6 Homo sapiens 146-150 20482831-9 2010 RESULTS: Pretreatment with DMF decreased synthesis of the proinflammatory mediators iNOS, TNF-alpha, IL-1beta and IL-6 at the RNA level in activated microglia and astrocytes in vitro, associated with a decrease in ERK phosphorylation in microglia. Dimethyl Fumarate 27-30 interleukin 6 Homo sapiens 114-118 19328000-2 2009 The structure-activity relationship of various substituents on an imidazoline core structure was evaluated for the ability to inhibit NF-kappaB mediated IL-6 production. Imidazolines 66-77 interleukin 6 Homo sapiens 153-157 19011039-5 2009 In MDA PCa 2b cells, growth stimulation by IL-6 was reversed by administration of either the non-steroidal anti-androgen bicalutamide or the inhibitor of the mitogen-activated protein kinase pathway PD98059. bicalutamide 121-133 interleukin 6 Homo sapiens 43-47 19965584-8 2010 Decreased IL-6 and IL-1(beta) levels correlated with decreased PGF(2alpha) levels. Prostaglandins F 63-66 interleukin 6 Homo sapiens 10-14 19011039-10 2009 In addition, bicalutamide showed an inhibitory effect on IL-6-regulated growth in vivo. bicalutamide 13-25 interleukin 6 Homo sapiens 57-61 19248856-9 2009 Serum interleukin-6 was inversely associated with intakes of legumes, vegetables, beta carotene, and vitamin C. beta Carotene 82-95 interleukin 6 Homo sapiens 6-19 20395894-9 2010 ADMA levels were related to the total Sequential Organ Failure Assessment (SOFA) scores and arginine levels, and inversely related to IL-6 and CRP levels. N,N-dimethylarginine 0-4 interleukin 6 Homo sapiens 134-138 20395894-11 2010 The ADMA/SDMA ratio was inversely related to IL-6 levels. N,N-dimethylarginine 4-8 interleukin 6 Homo sapiens 45-49 19443940-2 2009 Previous studies have revealed that therapy with leflunomide causes decreased production of mediators such as IL-1beta, IL-6, and TNF-alpha, which are involved in inflammatory process. Leflunomide 49-60 interleukin 6 Homo sapiens 120-124 19823118-0 2010 Lipoteichoic acid-induced TNF-alpha and IL-6 gene expressions and oxidative stress production in macrophages are suppressed by ketamine through downregulating Toll-like receptor 2-mediated activation oF ERK1/2 and NFkappaB. Ketamine 127-135 interleukin 6 Homo sapiens 40-44 19443940-3 2009 The aim of the present study was to examine whether the polymorphisms in genes IL1B, IL6, and TNF may affect treatment outcomes in RA patients treated with leflunomide. Leflunomide 156-167 interleukin 6 Homo sapiens 85-88 19823118-3 2010 In this study, we further evaluated the effects of ketamine on the regulation of LTA-induced TNF-alpha and IL-6 gene expressions and oxidative stress production in macrophages and its possible mechanisms. Ketamine 51-59 interleukin 6 Homo sapiens 107-111 19234585-2 2009 The purpose of this study was to evaluate the effects of supplementing older adults with alpha-linolenic acid (ALA) during a resistance training program, based on the hypothesis that ALA decreases the plasma concentration of the inflammatory cytokine tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, which in turn would improve muscle size and strength. alpha-Linolenic Acid 89-109 interleukin 6 Homo sapiens 289-307 19823118-4 2010 Exposure of macrophages to a therapeutic concentration of ketamine (100 microM) inhibited LTA-induced TNF-alpha and IL-6 expressions at protein or mRNA levels. Ketamine 58-66 interleukin 6 Homo sapiens 116-120 19823118-8 2010 Cotreatment with ketamine and PD98059 synergistically suppressed the LTA-induced translocation and transactivation of NFkappaB and biosyntheses of TNF-alpha and IL-6 mRNA. Ketamine 17-25 interleukin 6 Homo sapiens 161-165 19823118-10 2010 Cotreatment with ketamine and TLR2 siRNA synergistically lowered TNF-alpha and IL-6 mRNA syntheses in LTA-activated macrophages. Ketamine 17-25 interleukin 6 Homo sapiens 79-83 19234585-2 2009 The purpose of this study was to evaluate the effects of supplementing older adults with alpha-linolenic acid (ALA) during a resistance training program, based on the hypothesis that ALA decreases the plasma concentration of the inflammatory cytokine tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, which in turn would improve muscle size and strength. alpha-Linolenic Acid 183-186 interleukin 6 Homo sapiens 289-307 19234585-5 2009 Males supplementing with ALA decreased IL-6 concentration over the 12 weeks (62 +/- 36% decrease; p = 0.003), with no other changes in inflammatory cytokines. alpha-Linolenic Acid 25-28 interleukin 6 Homo sapiens 39-43 19234585-8 2009 ALA supplementation lowers the IL-6 concentration in older men but not women, but had minimal effect on muscle mass and strength during resistance training. alpha-Linolenic Acid 0-3 interleukin 6 Homo sapiens 31-35 18443862-7 2009 RESULTS: Open laparotomy resulted in significant elevation of serum IL-6 level when compared to the laparoscopic procedures in the descending order of open > air > CO(2) groups. Carbon Dioxide 170-175 interleukin 6 Homo sapiens 68-72 20222014-10 2010 Furthermore, the induction of Th17 cells was dependent on increased IL-6 production from major histocompatibility complex class II-expressing AC-treated MSC under osteogenic differentiation. Charcoal 142-144 interleukin 6 Homo sapiens 68-72 18461289-10 2009 Finally, the administration of ZA to patients with bone metastases induced a statistically significant increase of serum IL-6 and Cyst C only PCa patients with bone metastasis. Zoledronic Acid 31-33 interleukin 6 Homo sapiens 121-125 20218918-5 2010 RESULTS: In the patients with PTF, maximum mean plasma IL-6 and IL-8 values were found, respectively at 24 h (45.12 pg/mL) and 6 hours (21.7 pg/mL) postoperatively. Benzyl methyl sulfide 30-33 interleukin 6 Homo sapiens 55-59 18780777-5 2008 Taking advantage of these highly developed contractile C(2)C(12) myotubes, we identified myotube-derived factors responsive to EPS-evoked contraction, including the CXC chemokines CXCL1/KC and CXCL5/LIX, as well as IL-6, previously reported to be upregulated in contracting muscles in vivo. eps 127-130 interleukin 6 Homo sapiens 215-219 20222982-8 2010 HgCl2 also stimulated significant VEGF release (360 +/- 100 pg/106 cells at 1 microM, n = 5, p < 0.05) from hCBMCs compared to control cells (182 +/- 57 pg/106 cells), and IL-6 release (466 +/- 57 pg/106 cells at 0.1 microM) compared to untreated cells (13 +/- 25 pg/106 cells, n = 5, p < 0.05). Mercuric Chloride 0-5 interleukin 6 Homo sapiens 175-179 20222982-9 2010 Addition of HgCl2 (0.1 microM) to SP (5 microM) further increased IL-6 release. Mercuric Chloride 12-17 interleukin 6 Homo sapiens 66-70 18764842-2 2008 OBJECTIVES: The aim of this study was to evaluate whether 3 months of monotherapy with chloroquine influences the mRNA skin expression of interleukin (IL)-1beta, IL-6 and tumour necrosis factor-alpha (TNF-alpha) in nonirradiated and locally ultraviolet B (UVB) irradiated nondiseased skin of patients with systemic lupus erythematosus (SLE). Chloroquine 87-98 interleukin 6 Homo sapiens 162-166 19926874-6 2010 In contrast, secondary necrotic VSMCs release both IL-1alpha and caspase-activated IL-1beta, augmenting IL-6 and MCP-1 production. vsmcs 32-37 interleukin 6 Homo sapiens 104-108 18764842-7 2008 Significantly lower expression of IL-1beta, IL-6 and TNF-alpha mRNAs was noted in irradiated skin samples after 3 months of chloroquine treatment. Chloroquine 124-135 interleukin 6 Homo sapiens 44-48 19903755-4 2010 RESULTS: After adjustment for age, ethnicity, clinical center, time of blood draw, smoking, alcohol, physical activity, energy intake, BMI, and diabetes status, magnesium intake was inversely associated with hs-CRP (P for linear trend = 0.003), IL-6 (P < 0.0001), TNF-alpha-R2 (P = 0.0006), and sVCAM-1 (P = 0.06). Magnesium 161-170 interleukin 6 Homo sapiens 245-249 19903755-6 2010 Multivariable-adjusted geometric means across increasing quintiles of magnesium intake were 3.08, 2.63, 2.31, 2.53, and 2.16 mg/l for hs-CRP (P = 0.005); 2.91, 2.63, 2.45, 2.27, and 2.26 pg/ml for IL-6 (P = 0.0005); and 707, 681, 673, 671, and 656 ng/ml for sVCAM-1 (P = 0.04). Magnesium 70-79 interleukin 6 Homo sapiens 197-201 19903755-7 2010 An increase of 100 mg/day magnesium was inversely associated with hs-CRP (-0.23 mg/l +/- 0.07; P = 0.002), IL-6 (-0.14 +/- 0.05 pg/ml; P = 0.004), TNF-alpha-R2 (-0.04 +/- 0.02 pg/ml; P = 0.06), and sVCAM-1 (-0.04 +/- 0.02 ng/ml; P = 0.07). Magnesium 26-35 interleukin 6 Homo sapiens 107-111 20184800-10 2010 AG-1478 dual effects on IL-6 secretion induced by BK alone or BK plus EGF were also observed in cells treated with genistein, a tyrosine kinase inhibitor, and AG-825, an ErbB-2 inhibitor. tyrphostin AG825 159-165 interleukin 6 Homo sapiens 24-28 18633341-6 2008 Only IL-6 levels and age were found to be independent correlates in these growth hormone-induced variations in plasma potassium and blood amino acids. Potassium 118-127 interleukin 6 Homo sapiens 5-9 19583958-7 2009 SB202190 blunted IL-6, PGE2, and PGF2alpha production in a dose-dependent manner in co-culture. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 0-8 interleukin 6 Homo sapiens 17-21 19583958-10 2009 SB202190 successfully suppressed IL-6, IL-8, PGE2, and PGF2alpha secretion in macrophage-exposed AF cells in response to TNF-alpha. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 0-8 interleukin 6 Homo sapiens 33-37 18834270-0 2008 Tiopronin monolayer-protected silver nanoparticles modulate IL-6 secretion mediated by Toll-like receptor ligands. Tiopronin 0-9 interleukin 6 Homo sapiens 60-64 19878981-4 2009 Let-7 directly inhibits IL6 expression, resulting in higher levels of IL6 than achieved by NF-kappaB activation. let-7 0-5 interleukin 6 Homo sapiens 24-27 19878981-4 2009 Let-7 directly inhibits IL6 expression, resulting in higher levels of IL6 than achieved by NF-kappaB activation. let-7 0-5 interleukin 6 Homo sapiens 70-73 18577366-4 2008 The IL-6 in the serum sample is allowed to react immunologically with the immobilized anti-IL-6 and biotin-labeled second antibodies specific to IL-6. Biotin 100-106 interleukin 6 Homo sapiens 4-8 18615482-7 2008 RESULTS: Selective zinc deficiency induced by the membrane-permeable zinc chelator N,N,N",N"-tetrakis(2-pyridylmethyl)-ethylenediamine (TPEN) increases activation of NF-kappaB and up-regulates expression of the NF-kappaB controlled pro-angiogenic and pro-metastatic cytokines VEGF, IL-6 and IL-8 in androgen-independent PC-3 and DU-145 prostate cancer cells. N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine 136-140 interleukin 6 Homo sapiens 282-286 19701194-7 2009 The miR-26 family of miRNAs targets IL-6, and the addition of terminal uridines to the miR-26 3" end abrogates IL-6 repression. Uridine 71-79 interleukin 6 Homo sapiens 36-40 19701194-7 2009 The miR-26 family of miRNAs targets IL-6, and the addition of terminal uridines to the miR-26 3" end abrogates IL-6 repression. Uridine 71-79 interleukin 6 Homo sapiens 111-115 18449539-8 2008 Furthermore, multiple regression analysis revealed that the IL-6 level was independently predicted by the BMI and the myocardial uptake of (123)I-MIBG during the delayed phase. i-mibg 144-150 interleukin 6 Homo sapiens 60-64 19443277-5 2009 Dual treatment of rosiglitazone and losartan provided synergistic effect in reducing ICAM-1, IL-6 and ATR1 expression and NF-kappaB and ERK1/2 activation induced by the conditioned media when compared with monotherapy. Losartan 36-44 interleukin 6 Homo sapiens 93-97 19885014-5 2009 Results showed that EPA, DHA, or troglitazone significantly reduced COX-2 expression, NF-kappaB luciferase activity, and PGE(2) and IL-6 production in a dose-dependent fashion. Docosahexaenoic Acids 25-28 interleukin 6 Homo sapiens 132-136 18698233-5 2008 METHODS AND RESULTS: In cells expressing the 299D-399T TLR4, LPS activated the transcription factor NFkappaB and increased the expression of interleukin-6 and tumor necrosis factor-alpha, and these effects were reduced by pretreatment of the cells with pravastatin or simvastatin. Pravastatin 253-264 interleukin 6 Homo sapiens 141-186 19520090-7 2009 The expressions of MMPs, mast cell proteases, TNF-alpha, IL-6, SCF and pro-collagen I were lower in the nifedipine group than in the control group (P<0.05). Nifedipine 104-114 interleukin 6 Homo sapiens 57-61 18270326-4 2008 Functional AhR is responsible for the biologic activity of VAF347 because (1) other AhR agonists display an identical activity profile in vitro, (2) gene silencing of wild-type AhR expression or forced overexpression of a trans-dominant negative AhR ablates VAF347 activity to inhibit cytokine induced IL-6 expression in a human monocytic cell line, and (3) AhR-deficient mice are resistant to the compound"s ability to block allergic lung inflammation in vivo. VAF347 59-65 interleukin 6 Homo sapiens 302-306 19670170-10 2009 A significant increase in both hsCRP (p <0.05) and IL-6 (p=0.02) occurring 1 week after TC insertion was observed. Technetium 91-93 interleukin 6 Homo sapiens 54-58 19670170-11 2009 Elevation of the IL-6 levels appeared to be sustained 1 month after TC insertion, although this finding was not statistically significant (p=0.68), whereas the hsCRP levels returned to baseline within 1 month. Technetium 68-70 interleukin 6 Homo sapiens 17-21 18662595-2 2008 In this study, the association of osteoporosis with three IL-6 gene markers (a CA dinucleotide repeat and two single nucleotide polymorphisms [SNPs]: G-174C and G-572C) was tested in the Mexican population. ca dinucleotide 79-94 interleukin 6 Homo sapiens 58-62 19373973-0 2009 Randomized study of the effect of pentoxifylline or octreotide on serum levels of TNF-alpha and IL-6 after endoscopic retrograde cholangiopancreatography. Pentoxifylline 34-48 interleukin 6 Homo sapiens 96-100 19373973-0 2009 Randomized study of the effect of pentoxifylline or octreotide on serum levels of TNF-alpha and IL-6 after endoscopic retrograde cholangiopancreatography. Octreotide 52-62 interleukin 6 Homo sapiens 96-100 20157364-7 2008 Oral administration of pravastatin, 40mg daily for 2 days, decreased CRP-stimulated IL-6 production by approximately 20% (P = 0.02) 6 hours after incubation, but did not affect MCP-1 production (P = 0.69). Pravastatin 23-34 interleukin 6 Homo sapiens 84-88 19373973-1 2009 OBJECTIVES: To study the effect of pentoxifylline and octreotide administration on serum levels of TNF-alpha and IL-6, in patients who underwent endoscopic retrograde cholangiopancreatography (ERCP), whether they developed pancreatitis or not. Octreotide 54-64 interleukin 6 Homo sapiens 113-117 18523665-12 2008 An addition of AG-490, a selective inhibitor of the JAK2-STAT3 pathway, significantly inhibited PDGF-mediated STAT3 induction and cell growth and migration in HSF. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 15-21 interleukin 6 Homo sapiens 159-162 19241441-5 2009 Evodiamine and rutaecarpine decreased the LIGHT-induced production of ROS, IL-8, monocyte chemoattractant protein-1 (MCP-1), TNF-alpha, and IL-6, as well as the expression of chemokine receptor (CCR) 1, CCR2 and ICAM-1 and the phosphorylation of the ERK 1/2 and p38 MAPK. evodiamine 0-10 interleukin 6 Homo sapiens 140-144 21983371-9 2012 On days 3 and 7, methylprednisolone decreased interleukin-6 and increased protein C levels (all p < .0001) compared with control subjects. Methylprednisolone 17-35 interleukin 6 Homo sapiens 46-59 18237545-5 2008 These antibodies also decreased the basal PA-activity of HT-29 cells and neutralized their cytokines (Interleukin-1beta+Interleukin-6)-enhanced PA-activity. Protactinium 144-146 interleukin 6 Homo sapiens 120-133 21983371-11 2012 Methylprednisolone decreased interleukin-6 by days 3 and 7 in patients with pulmonary causes of acute respiratory distress syndrome but only at day 3 in those with extrapulmonary causes of acute respiratory distress syndrome. Methylprednisolone 0-18 interleukin 6 Homo sapiens 29-42 22015639-10 2012 H(2)S-induced expression of IL-6, IL-8 and COX-2 was completely blocked by specific inhibitors of p38 and ERK1/2 MAPK and NF-kappaB. Hydrogen Sulfide 0-5 interleukin 6 Homo sapiens 28-32 19245380-9 2009 The mean plasma IL-6 concentration at 24 hours was 25.41 pg/mL in the SES group versus 17.44 pg/mL in the BMS group (P = 0.17). ses 70-73 interleukin 6 Homo sapiens 16-20 18389318-8 2009 However, the rise in IL-6 and CRP in OP group was significantly more robust than in LP group. leucylproline 84-86 interleukin 6 Homo sapiens 21-25 18415826-0 2008 Effect of budesonide and formoterol on IL-6 and IL-8 release from primary bronchial epithelial cells. Formoterol Fumarate 25-35 interleukin 6 Homo sapiens 39-43 19567096-4 2009 RESULTS: The serum MIF, TNF-alpha, and IL-6 levels of the DM, DPN, and DPNP groups were all significantly higher than those of the control group (P < 0. di-n-pentyl phthalate 71-75 interleukin 6 Homo sapiens 39-43 19220089-8 2009 Patients in the PTX group had lower postoperative plasma levels of TNF-alpha (0.27 pg/mL (0.06/0.74) v 3.35 pg/mL (0.83/6.41)) (median (25%/75%), P < 0.0001) and IL-6 (35.4 +/- 21.1 pg/mL (range 12-100) v 60.4 +/- 16.7 pg/mL (range 38-100), mean +/- standard deviation, P < 0.001) compared with the placebo receivers. Pentoxifylline 16-19 interleukin 6 Homo sapiens 165-169 21760473-9 2012 However, the decreases in UAE, serum HMGB1 and serum IL-6 were significantly greater in the telmisartan group than in the enalapril group at 6 months (P < 0.05, P < 0.01 and P < 0.01, respectively) and 12 months (all, P < 0.05). Telmisartan 92-103 interleukin 6 Homo sapiens 53-57 18415826-4 2008 Formoterol increased the IL-6 release but did not influence the IL-8 release. Formoterol Fumarate 0-10 interleukin 6 Homo sapiens 25-29 22419431-13 2012 The IL-6 production induced by UVB was lower in beta-thujaplicin treated fibroblasts than in the controls. beta-thujaplicin 48-64 interleukin 6 Homo sapiens 4-8 17915188-0 2008 Lysophosphatidic acid-stimulated interleukin-6 and -8 synthesis through LPA1 receptors on human osteoblasts. lysophosphatidic acid 0-21 interleukin 6 Homo sapiens 33-53 19027837-6 2009 An induction of the mRNA expression of IL-6 by DON was evident only at 3h, whereas the supernatant concentrations of LPS stimulated PAM incubated with 500nM DON were significantly decreased at most time points. deoxynivalenol 47-50 interleukin 6 Homo sapiens 39-43 17915188-4 2008 The expression of IL-6 and IL-8 mRNAs was maximal at 1-3h, and the increase in IL-6 and IL-8 synthesis in response to lysophosphatidic acid (1-10 microM) occurred in a concentration-dependent manner. lysophosphatidic acid 118-139 interleukin 6 Homo sapiens 18-22 23023149-7 2012 In vitro tests showed that when PTX was released more slowly from crosslinked scaffolds, PTX became more effective in suppressing macrophage cells from releasing IL-6 and TNF-alpha. Pentoxifylline 32-35 interleukin 6 Homo sapiens 162-166 23023149-7 2012 In vitro tests showed that when PTX was released more slowly from crosslinked scaffolds, PTX became more effective in suppressing macrophage cells from releasing IL-6 and TNF-alpha. Pentoxifylline 89-92 interleukin 6 Homo sapiens 162-166 19799786-11 2009 IL-6 was elevated in ATA-positive and ARA-positive patients, but not in ACA-positive patients. Arabinose 38-41 interleukin 6 Homo sapiens 0-4 17915188-4 2008 The expression of IL-6 and IL-8 mRNAs was maximal at 1-3h, and the increase in IL-6 and IL-8 synthesis in response to lysophosphatidic acid (1-10 microM) occurred in a concentration-dependent manner. lysophosphatidic acid 118-139 interleukin 6 Homo sapiens 79-83 17915188-7 2008 The pretreatment of SaM-1 cells with U-73122, a phospholipase C (PLC) inhibitor, and 2-APB also inhibited the increase in IL-6 and IL-8 synthesis in response to LPA. lysophosphatidic acid 161-164 interleukin 6 Homo sapiens 122-126 17915188-8 2008 These findings suggest that extracellular LPA-induced IL-6 and IL-8 synthesis occurred through Edg-2 (LPA(1) receptor) and the activation of PLC and IP(3)-mediated intracellular calcium release in SaM-1 cells. lysophosphatidic acid 42-45 interleukin 6 Homo sapiens 54-58 22121485-9 2012 In comparison to AVFs, the presence of a TC was associated with significantly higher levels of CRP (P = 0.03), IL-6 (P = 0.07), and IP-10 (P = 0.03). Technetium 41-43 interleukin 6 Homo sapiens 111-115 19164258-7 2009 beta-Cryptoxanthin, lycopene, and lutein/zeaxanthin concentrations were inversely related to interleukin-6 concentrations. Lutein 34-40 interleukin 6 Homo sapiens 93-106 17922475-9 2008 IL-6 production was stimulated by PMA in both C and T2D patients; this effect was prevented by rosiglitazone in a Sr202-inhibitable manner. mifobate 114-119 interleukin 6 Homo sapiens 0-4 22013105-9 2012 The plasma concentrations of monocyte chemoattractant protein-1, matrix metalloproteinase-9, serum amyloid A, and IL-6 were suppressed after 12 wk exenatide treatment by 15 +- 7, 20 +- 11, 16 +- 7, and 22 +- 12%, respectively (P < 0.05 for all). Exenatide 147-156 interleukin 6 Homo sapiens 114-118 22420547-7 2012 A decrease in Il-6 level after application of Cisplatin and Methotrexate and a 5-10 fold increase in the level of Il-6 after application of Etoposide, Carboplatin, Cytarabine, and Gemcitabine were registered in the medium with ganglioneuroblastoma. Cytarabine 164-174 interleukin 6 Homo sapiens 114-118 18835660-12 2009 In conclusion, increase of BMI appears to be related to clozapine"s and olanzapine"s similar effects on cytokine systems, whilst drug-induced fever appears to be related to clozapine"s differential effects on interleukin-6. Clozapine 173-182 interleukin 6 Homo sapiens 209-222 18557135-7 2008 We here show that exposure to IL-1 and IL-6 significantly increased the levels of DCF-detectable ROS in cells cultured in physiologic concentrations of Mg, but not in Mg-deprived cells. 2',7'-dichlorofluorescein 82-85 interleukin 6 Homo sapiens 39-43 19459427-8 2009 Losartan in both groups had an antihypertensive effect, stabilized LV hypertrophy, improved clinical symptoms leading to cytokines expression decline: TNF alpha by 9.8%, IL-1--by 6.1%, IL-6--by 6.7%. Losartan 0-8 interleukin 6 Homo sapiens 185-189 22302924-0 2012 Intraperitoneal IL-6 signaling in incident patients treated with icodextrin and glucose bicarbonate/lactate-based peritoneal dialysis solutions. glucose-bicarbonate 80-99 interleukin 6 Homo sapiens 16-20 18217720-25 2008 Madindoline A binds to gp130 selectively and inhibits IL-6 activity. madindoline A 0-13 interleukin 6 Homo sapiens 54-58 21693690-6 2011 Stimulation of NOD1 with a synthetic ligand Tri-DAP induces proinflammatory chemokine MCP-1, RANTES, and cytokine TNF-alpha and MIP-2 (human IL-8 homolog) and IL-6 mRNA expression in 3T3-L1 adipocytes in a time- and dose-dependent manner. L-Ala-gamma-D-Glu-meso-diaminopimelic acid 44-51 interleukin 6 Homo sapiens 159-163 19206545-7 2008 Furthermore, at 4 nm thick per layer, orders of magnitude thinner than conventional drug delivery coatings, these dexamethasone-copolymer mixtures (PolyDex) suppressed in vitro expression of the inflammatory cytokines/signaling elements interleukin 6 (IL-6), interleukin 12 (IL-12), tumor necrosis factor alpha (TNFalpha), inducible nitric oxide synthase (iNOS), and interferon gamma inducible protein (IP-10). copolymer 128-137 interleukin 6 Homo sapiens 237-250 21798957-10 2011 CONCLUSIONS: According to the current results, acute phase reactants such as IL6 and CFB are associated with fasting glucagon in metabolically compromised subjects. Glucagon 117-125 interleukin 6 Homo sapiens 77-80 19092349-9 2008 RESULTS: After methylprednisolone treatment, steroid plasma levels were significantly higher (P < 0.05), and a significant decrease in soluble interleukins, monocyte chemotactic protein-1, interleukin-2, interleukin-6, tumor necrosis factor-alpha, and inducible protein-10 was observed. Methylprednisolone 15-33 interleukin 6 Homo sapiens 207-249 18975348-9 2008 In vitro, treatment with fasudil or Y27632 decreased production of tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and IL-6 by synovial membrane cells, peripheral blood mononuclear cells, and fibroblast-like synoviocytes from patients with active RA. Y 27632 36-42 interleukin 6 Homo sapiens 141-145 21929671-2 2011 GOAL: To determine the effect of ketamine on IL-6 levels in liver resections patients with a temporary porto-arterial occlusion (Pringle manoeuvre). Ketamine 33-41 interleukin 6 Homo sapiens 45-49 19206545-7 2008 Furthermore, at 4 nm thick per layer, orders of magnitude thinner than conventional drug delivery coatings, these dexamethasone-copolymer mixtures (PolyDex) suppressed in vitro expression of the inflammatory cytokines/signaling elements interleukin 6 (IL-6), interleukin 12 (IL-12), tumor necrosis factor alpha (TNFalpha), inducible nitric oxide synthase (iNOS), and interferon gamma inducible protein (IP-10). copolymer 128-137 interleukin 6 Homo sapiens 252-256 18758908-7 2008 Girls with CC genotype of IL-6 -634G/C gene had higher percentage accrual in BMD of total body (P = 0.032) and femoral trochanter (P = 0.048) than their CG + GG counterparts. cysteinylglycine 153-155 interleukin 6 Homo sapiens 26-30 21809148-1 2011 PURPOSE: We hypothesized that patients who received ketamine during thoracic surgery would benefit from suppression of the inflammatory cascade, represented by lower interleukin (IL)-6 and C-reactive protein (CRP) plasma levels. Ketamine 52-60 interleukin 6 Homo sapiens 166-184 19060982-7 2008 At all three test times, the medians for CRP and IL-6 were significantly more elevated in the CS and PS groups, while the medians for TNF-alpha were abnormal only in the CS group. ps 101-103 interleukin 6 Homo sapiens 49-53 19205364-13 2008 In vitro valproate inhibits TNFa and IL-6 production, whereas in epileptic patients this drug enhances IL-1, IL-6 and IL-5 concentration. Valproic Acid 9-18 interleukin 6 Homo sapiens 37-41 18771379-7 2008 RESULTS: The secretion of IL-1beta and -8 and TNF-alpha by macrophages decreased significantly (P <0.05) when they were pretreated with 2 microM doxycycline, whereas a concentration of 10 microM was required to significantly reduce IL-6 secretion. Doxycycline 148-159 interleukin 6 Homo sapiens 235-239 21119093-5 2011 Bezafibrate treatment normalized monocyte release of MCP-1, interleukin-6, TNF-alpha, and interleukin-1beta and also normalized plasma hsCRP levels in mixed dyslipidemic subjects, whereas in IFG individuals the drug reduced only MCP-1 and interleukin-6 release. Bezafibrate 0-11 interleukin 6 Homo sapiens 60-73 21119093-5 2011 Bezafibrate treatment normalized monocyte release of MCP-1, interleukin-6, TNF-alpha, and interleukin-1beta and also normalized plasma hsCRP levels in mixed dyslipidemic subjects, whereas in IFG individuals the drug reduced only MCP-1 and interleukin-6 release. Bezafibrate 0-11 interleukin 6 Homo sapiens 239-252 17548183-4 2007 After controlling for demographic factors and other covariates (age, gender, race, body mass index and white blood cell count), hierarchical regression analyses revealed an inverse association between trait PA and stimulated production of IL-6 (DeltaR(2)=.03, b=-.18, p <.04) and IL-10 (DeltaR(2)=.09; b =-.32, p <.01), with the latter association obtained only in men. Protactinium 207-209 interleukin 6 Homo sapiens 239-243 21979989-7 2011 OCT inhibited PBMC proliferation in a dose-dependent manner and decreased the secretion of interleukin-6 (IL-6), interleukin-10 (IL-10), and interferon-gamma (IFN-gamma). Octreotide 0-3 interleukin 6 Homo sapiens 91-104 21979989-7 2011 OCT inhibited PBMC proliferation in a dose-dependent manner and decreased the secretion of interleukin-6 (IL-6), interleukin-10 (IL-10), and interferon-gamma (IFN-gamma). Octreotide 0-3 interleukin 6 Homo sapiens 106-110 18468661-10 2008 CONCLUSIONS: The IL-6 levels had decreased significantly after antibiotic therapy in patients with CP/CPPS, suggesting a bacterial inflammatory character. cpps 102-106 interleukin 6 Homo sapiens 17-21 18580215-10 2008 Significant increases in systemic IL-6 and IL-8 values were measured only in patients undergoing DAP and SP. dap 97-100 interleukin 6 Homo sapiens 34-38 17446059-6 2007 EGCG significantly inhibited the IL-1beta+Abeta (25-35)-induced IL-6, IL-8, vascular endothelial growth factor (VEGF) and prostaglandin (PG)E(2) production at 24 h (P<.01). UNII-042A8N37WH 42-47 interleukin 6 Homo sapiens 64-68 21333270-7 2011 In vitro results also suggested that stimulation of Tca-8113 cells with TLR-9 agonist CpG-ODN could significantly increase tumour cell proliferation as well as subsequent IL-1alpha and IL-6 secretions (P<0.01), which could be partially inhibited by usage of anti-TLR-9 protein. Trichloroacetic Acid 52-55 interleukin 6 Homo sapiens 185-189 18566387-9 2008 cis-UCA also increased cytokine protein production such as that of TNF-alpha, IL-6, and IL-8 in a dose-dependent manner. cis-Urocanic acid 0-7 interleukin 6 Homo sapiens 78-82 17590218-9 2007 Both after a single or repeated administration, nimesulide significantly reduced the synovial fluid concentrations of SP and IL-6. nimesulide 48-58 interleukin 6 Homo sapiens 125-129 18541548-8 2008 Changes in the DHA and EPA concentrations were negatively associated with changes in IL-1beta and IL-6 release for all subjects. Docosahexaenoic Acids 15-18 interleukin 6 Homo sapiens 98-102 18541548-11 2008 CONCLUSION: AD patients treated with DHA-rich n-3 FAs supplementation increased their plasma concentrations of DHA (and EPA), which were associated with reduced release of IL-1beta, IL-6, and granulocyte colony-stimulating factor from PBMCs. Docosahexaenoic Acids 37-40 interleukin 6 Homo sapiens 182-186 18541548-11 2008 CONCLUSION: AD patients treated with DHA-rich n-3 FAs supplementation increased their plasma concentrations of DHA (and EPA), which were associated with reduced release of IL-1beta, IL-6, and granulocyte colony-stimulating factor from PBMCs. Docosahexaenoic Acids 111-114 interleukin 6 Homo sapiens 182-186 21700754-10 2011 The increase from baseline in adiponectin levels and the decreases from baseline in interleukin 6 and tumour necrosis factor alpha levels were significantly greater in the telmisartan group at 8 months. Telmisartan 172-183 interleukin 6 Homo sapiens 84-130 20854895-5 2011 Pretreatment of DC with DHA prevented LPS-induced DC maturation, maintaining an immature phenotype characterized by low expression of costimulatory molecules and lack of proinflammatory cytokine production (IL-12p70, IL-6, and IL-23). Docosahexaenoic Acids 24-27 interleukin 6 Homo sapiens 217-221 17118622-8 2007 In addition, DNCB and NiSO(4) augmented CD1a expression and production of IL-6, respectively. Dinitrochlorobenzene 13-17 interleukin 6 Homo sapiens 74-78 21566261-7 2011 DHEA replacement improved glucose tolerance in participants who had abnormal GT initially, reduced plasma triglycerides, and the inflammatory cytokines IL6 and TNFalpha. Dehydroepiandrosterone 0-4 interleukin 6 Homo sapiens 152-155 18412147-4 2008 However, pretreatment with Daesiho significantly inhibited the secretion of pro-inflammatory cytokines, including TNF-alpha, IL-1beta, and IL-6, in stimulated PBMCs and THP-1/M cells. daesiho 27-34 interleukin 6 Homo sapiens 139-143 18371939-10 2008 RT-PCR analysis manifested a downregulation of mRNA expression of TNF-alpha, IL-6 and MMP-9 in both NSCs groups, but further decrease in DFX-treated NSCs group. Deferoxamine 137-140 interleukin 6 Homo sapiens 77-81 17565849-3 2007 Then ELISA was conducted to examine the levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNFalpha) Bicinchoninic acid method was used to standardize the cell total protein level. bicinchoninic acid 114-132 interleukin 6 Homo sapiens 65-102 18191973-0 2008 Ketamine inhibits tumor necrosis factor-alpha and interleukin-6 gene expressions in lipopolysaccharide-stimulated macrophages through suppression of toll-like receptor 4-mediated c-Jun N-terminal kinase phosphorylation and activator protein-1 activation. Ketamine 0-8 interleukin 6 Homo sapiens 50-63 18387391-0 2008 Urinary epidermal growth factor and interleukin-6 levels in patients with painful bladder syndrome/interstitial cystitis treated with cyclosporine or pentosan polysulfate sodium. Pentosan Sulfuric Polyester 150-177 interleukin 6 Homo sapiens 36-49 18266269-4 2008 PPG 1200 was the most potent inhibitor tested, shown for TNF, IL-1beta, IL-6, IL-8, IL-10 and TGF-beta induction, and displayed no cytotoxic effects. ppg 1200 0-8 interleukin 6 Homo sapiens 72-76 21172926-8 2011 Treatment with SB202190 (p38-MAPK inhibitor) or PD98059 (ERK inhibitor) inhibited AGE-BSA-induced IL-6 and IL-8 expression. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 15-23 interleukin 6 Homo sapiens 98-102 21406101-11 2011 Interleukin (IL)-6 and C-reactive protein (CRP) showed a significantly quicker decrease after 24 h of treatment among patients treated with MPDN. Methylprednisolone 140-144 interleukin 6 Homo sapiens 0-18 21358504-1 2011 OBJECTIVE: To examine the effect of ingestion of omega-3 (N-3) fatty acids on the production of interleukin (IL) 6, tumor necrosis factor (TNF) alpha, prostaglandin (PG) E2, lactate dehydrogenase (LDH), creatine kinase (CK), and myoglobin (Mb) during an eccentric exercise program. omega-3 (n-3) fatty acids 49-74 interleukin 6 Homo sapiens 96-114 18209571-6 2008 IL-6 promoter activity was diminished by U0126 or SB202190, but not by SP600125. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 50-58 interleukin 6 Homo sapiens 0-4 17284733-7 2007 RESULTS: IL-6, IL-1beta, and TNF-alpha production by PBMCs and serum TNF-alpha concentrations were lower (P < 0.05 and P < 0.08, respectively) with the ALA diet than with the LA diet or AAD. alpha-Linolenic Acid 158-161 interleukin 6 Homo sapiens 9-13 17325741-6 2007 Our results strongly suggest that SPARC exerts a dual inhibitory effect on LPA-induced mesothelial-ovarian cancer cell crosstalk through the regulation of both LPA-induced IL-6 production and function. lysophosphatidic acid 75-78 interleukin 6 Homo sapiens 172-176 17956865-5 2007 Both IL-6-inducible gamma-FBG reporter gene and endogenous mRNA expression are significantly decreased after CDK9 inhibition using the potent CDK inhibitor, flavopiridol (FP), or specific CDK9 siRNA. alvocidib 157-169 interleukin 6 Homo sapiens 5-9 17956865-5 2007 Both IL-6-inducible gamma-FBG reporter gene and endogenous mRNA expression are significantly decreased after CDK9 inhibition using the potent CDK inhibitor, flavopiridol (FP), or specific CDK9 siRNA. alvocidib 171-173 interleukin 6 Homo sapiens 5-9 21779488-5 2011 The authors have previously identified andrographolide as an inhibitor of interleukin-6, which can suppress tumor growth of prostate cancer cells by screening compounds from the Prestwick Natural compound library. andrographolide 39-54 interleukin 6 Homo sapiens 74-87 20632303-4 2011 Treatment of Mono Mac 6 cells with the residue of a crude dichloromethane extract of rose hip powder significantly and concentration dependently inhibited the lipopolysaccharide induced interleukin-6 release. Methylene Chloride 58-73 interleukin 6 Homo sapiens 186-199 17325741-6 2007 Our results strongly suggest that SPARC exerts a dual inhibitory effect on LPA-induced mesothelial-ovarian cancer cell crosstalk through the regulation of both LPA-induced IL-6 production and function. lysophosphatidic acid 160-163 interleukin 6 Homo sapiens 172-176 18036359-4 2007 After 8 months of follow-up, only the telmisartan group showed significant decreases in interleukin-6 and tumor necrosis factor-alpha. Telmisartan 38-49 interleukin 6 Homo sapiens 88-133 17308162-17 2006 Finally, raloxifene decreases the vascular cell adhesion molecules and the inflammatory cytokines TNF-alpha and IL-6. Raloxifene Hydrochloride 9-19 interleukin 6 Homo sapiens 112-116 17720876-6 2007 A 5-10% dilution of FLDE stimulated a significant release of IL-6 and IL-8 at 6-24 h in a PKC-dependent manner vs. control medium-treated cells. flde 20-24 interleukin 6 Homo sapiens 61-65 21242686-9 2011 A significant reduction in plasma CRP and IL-6 levels was observed in the Vit E PS group: CRP from 6.7 +- 4.8 to 4.8 +- 2.2 mg/l (p < 0.001) and IL-6 from 12.1 +- 1.4 to 7.5 +- 0.4 pg/ml (p < 0.05). vit 74-77 interleukin 6 Homo sapiens 42-46 21242686-9 2011 A significant reduction in plasma CRP and IL-6 levels was observed in the Vit E PS group: CRP from 6.7 +- 4.8 to 4.8 +- 2.2 mg/l (p < 0.001) and IL-6 from 12.1 +- 1.4 to 7.5 +- 0.4 pg/ml (p < 0.05). vit 74-77 interleukin 6 Homo sapiens 148-152 17089010-0 2006 Comano"s (Trentino) thermal water interferes with interleukin-6 production and secretion and with cytokeratin-16 expression by cultured human psoriatic keratinocytes: further potential mechanisms of its anti-psoriatic action. trentino 10-18 interleukin 6 Homo sapiens 50-63 17338907-5 2006 The mean IL-6 concentration increased from 3 pg/ml in both groups pre-operatively to 78.5 pg/ml (PL group) vs 74.8 pg/ml (MIS group) at 6 hours post-operatively and reached a maximum of 100 pg/ml (PL group) vs 90.5 pg/ml pg/ml (MIS group) after 24 hours. pl 97-99 interleukin 6 Homo sapiens 9-13 21182500-16 2011 Increased expression of IL-6 in PP skin lesions may explain the effects of doxycycline in terms of its anti-inflammatory properties. Doxycycline 75-86 interleukin 6 Homo sapiens 24-28 21430794-0 2011 Increase in IL-6 levels among major depressive disorder patients after a 6-week treatment with duloxetine 60 mg/day: a preliminary observation. Duloxetine Hydrochloride 95-105 interleukin 6 Homo sapiens 12-16 21430794-9 2011 Nonetheless, the trend of increasing IL-6 levels observed in responder patients treated with duloxetine should prompt further controlled, extended studies with larger samples, with the specific aim of better assessing a putative differential role of norepinephrinergic antidepressant stimulation of serotonergic reuptake inhibition in determining modifications in IL-6 levels. Duloxetine Hydrochloride 93-103 interleukin 6 Homo sapiens 37-41 17531241-8 2007 Atazanavir increased the cytoplasmic levels of HuR and enhanced the binding of HuR to 3"-UTR of TNF-alpha and IL-6. Atazanavir Sulfate 0-10 interleukin 6 Homo sapiens 110-114 17531241-9 2007 Down regulation of HuR expression by siRNA prevented atazanavir-induced increase of TNF-alpha and IL-6. Atazanavir Sulfate 53-63 interleukin 6 Homo sapiens 98-102 18030179-7 2007 RESULTS: PMX-F treatment significantly increased systolic and diastolic blood pressures (P = 0.0004 for both) and significantly reduced heart rate (P < 0.0001), the blood endotoxin level (P = 0.0011), blood IL-6 level (P = 0.039), C-reactive protein level (P < 0.0001), and white blood cell count (P < 0.0001). pmx-f 9-14 interleukin 6 Homo sapiens 210-214 21430794-9 2011 Nonetheless, the trend of increasing IL-6 levels observed in responder patients treated with duloxetine should prompt further controlled, extended studies with larger samples, with the specific aim of better assessing a putative differential role of norepinephrinergic antidepressant stimulation of serotonergic reuptake inhibition in determining modifications in IL-6 levels. Duloxetine Hydrochloride 93-103 interleukin 6 Homo sapiens 364-368 17338907-5 2006 The mean IL-6 concentration increased from 3 pg/ml in both groups pre-operatively to 78.5 pg/ml (PL group) vs 74.8 pg/ml (MIS group) at 6 hours post-operatively and reached a maximum of 100 pg/ml (PL group) vs 90.5 pg/ml pg/ml (MIS group) after 24 hours. pl 197-199 interleukin 6 Homo sapiens 9-13 17130674-5 2006 2-APB [(2-aminoethoxy)diphenylborane], an inositol 1,4,5-trisphosphate (IP(3))-receptor antagonist, inhibited UTP-induced IL-6 mRNA expression; and the action of A23187, a Ca(2+) ionophore, resembled the action of UTP. 2-aminoethoxydiphenylborane 7-36 interleukin 6 Homo sapiens 122-126 22180363-3 2011 The purpose of this study is to assess the correlation between concentration of neopterin and IL-6 in the CSF and serum, and the course of HSE. Neopterin 80-89 interleukin 6 Homo sapiens 94-98 22180363-8 2011 Negative correlations between concentration of IL-6 and neopterin and patient condition assessed by Glasgow Coma Scale (GCS) were observed. Neopterin 56-65 interleukin 6 Homo sapiens 47-51 17729120-8 2007 Statins and Y27632 also further increased the interleukin-6 secretion in the LT-treated 3T3-L1 adipocytes. Y 27632 12-18 interleukin 6 Homo sapiens 46-59 17572062-3 2007 Protein profiling showed that benzene metabolites can stimulate the production of chemokines, the proinflammatory cytokines TNF-alpha and IL-6, and the Th2 cytokines IL-4 and IL-5. Benzene 30-37 interleukin 6 Homo sapiens 138-142 17253943-7 2006 Co-incubation with LPA attenuated the LPS-induced production of IL-6, without significantly affecting IL-10 secretion or the ability of DC to promote T cell proliferation. lysophosphatidic acid 19-22 interleukin 6 Homo sapiens 64-68 17876544-10 2007 Inhibitors for ERK (PD98059 and U0216) and p38 MAPK (SB203580) significantly reduced the IL-17F-induced IL-6, IL-8, LIF, MMP-1, and MMP-3 secretion. u0216 32-37 interleukin 6 Homo sapiens 104-108 21162728-12 2010 A p38 inhibitor (SB202190) strongly reduced DEP-induced expression of IL-6, IL-8 and COX-2, but only moderately affected the expression of CYP1A1. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 17-25 interleukin 6 Homo sapiens 70-74 20953204-7 2010 H-89, an inhibitor of cAMP-dependent protein kinase (PKA), abolished the inhibitory effects of rimonabant on TNF-alpha induced IL-6 production. N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide 0-4 interleukin 6 Homo sapiens 127-131 17122970-1 2006 OBJECTIVE AND DESIGN: In this ex vivo laboratory study, we investigated the effects of E5564 (eritoran), a toll-like receptor 4-directed endotoxin antagonist, on intracellular expression of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha in lipopolysaccharide (LPS)-stimulated human monocytes assessed by flow cytometry. E5564 87-92 interleukin 6 Homo sapiens 190-208 20953204-10 2010 CONCLUSION: Rimonabant had anti-inflammatory effects on endothelial cells and inhibited TNF-alpha-induced IKKalpha/beta phosphorylation, IkappaB-alpha degradation and IL-6 production in HUVEC. Rimonabant 12-22 interleukin 6 Homo sapiens 167-171 20725963-1 2010 The formation of hypertrophic scars (HSF) is a frequent medical outcome of wound repair and often requires further therapy with treatments such as silicone gel sheets (SGS) or apoptosis-inducing agents, including bleomycin. Silicones 147-155 interleukin 6 Homo sapiens 37-40 17689974-4 2007 IL-6 had positive relations with CRP, fibrinogen, ox-LDL and PGF(2alpha). Prostaglandins F 61-64 interleukin 6 Homo sapiens 0-4 17122970-5 2006 RESULTS: Our investigation showed that E5564 (0.03 ng/ml up to 10 ng/ml) caused a dose-dependent inhibitory effect on IL-6 and TNF-alpha production in LPS-stimulated human monocytes. E5564 39-44 interleukin 6 Homo sapiens 118-122 17122970-6 2006 CONCLUSIONS: The results of this investigation led us to conclude that E5564 has a remarkable LPS inhibitory activity manifested via down-regulation of the intracellular generation of pro-inflammatory cytokines IL-6 and TNF-alpha in human monocytes. E5564 71-76 interleukin 6 Homo sapiens 211-215 21991036-5 2006 In the present investigation, LMWH-treated patients exhibited a faster decline in levels of serum IL-6 (within 12 days) than control. Heparin, Low-Molecular-Weight 30-34 interleukin 6 Homo sapiens 98-102 17433832-10 2007 LPS-stimulated IL-6, TNF-alpha, PGE(2) and PGF(2alpha) release was significantly suppressed by treatment with all concentrations of SB202190, whereas ILS-stimulated IL-1beta release was only significantly inhibited in the presence of 50 microM SB202190 and there was no effect of SB202190 on LPS-stimulated IL-8 release. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 132-140 interleukin 6 Homo sapiens 15-19 17588396-8 2007 Methylprednisolone attenuated postoperative tumor necrosis factor-alpha, interleukin 6, interleukin 8, and C-reactive protein levels while increasing interleukin 10 release. Methylprednisolone 0-18 interleukin 6 Homo sapiens 73-86 20959795-5 2010 In addition, we observed that the plasma levels of interleukin (IL)-6 were higher in the DSS-treated group than in the control group, but these increased levels were reduced by the administration of vanillic acid. Vanillic Acid 199-212 interleukin 6 Homo sapiens 51-69 19004529-5 2010 The negative association between higher homocysteine and immediate recall was strongest in persons with a high level of IL-6. Homocysteine 40-52 interleukin 6 Homo sapiens 120-124 17314215-2 2007 In this study, we explored the effect of artesunate, an artemisinin derivative, on tumour necrosis factor (TNF)-alpha-induced production of interleukins, IL-1beta, IL-6 and IL-8, in human rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS), and further investigated the signal mechanism by which this compound modulates those cytokines" production. Artesunate 41-51 interleukin 6 Homo sapiens 164-168 17028376-7 2006 An increase in loge selenium was associated with a reduced risk of anemia (odds ratio per 1 SD increase = 0.63, 95% confidence interval = 0.47-0.84), adjusting for age, education, chronic diseases, iron status, and serum interleukin-6. Selenium 20-28 interleukin 6 Homo sapiens 221-234 17314215-6 2007 RESULTS: Artesunate decreased the secretion of IL-1beta, IL-6 and IL-8 from TNF-alpha-stimulated RA FLS in a dose-dependent manner. Artesunate 9-19 interleukin 6 Homo sapiens 57-61 17314215-9 2007 These observations suggest that artesunate inhibits production of IL-1beta, IL-6 and IL-8 through inhibition of NF-kappaB signalling pathway. Artesunate 32-42 interleukin 6 Homo sapiens 76-80 17569118-7 2007 Propionate dose-dependently suppressed IL-6 mRNA and protein release from colon organ cultures and comparative studies revealed that propionate and butyrate at 30 mmol/L caused a strong inhibition of immune-related gene expression, whereas acetate was less effective. Propionates 0-10 interleukin 6 Homo sapiens 39-43 17569118-7 2007 Propionate dose-dependently suppressed IL-6 mRNA and protein release from colon organ cultures and comparative studies revealed that propionate and butyrate at 30 mmol/L caused a strong inhibition of immune-related gene expression, whereas acetate was less effective. Propionates 133-143 interleukin 6 Homo sapiens 39-43 20734355-4 2010 When cocultured with GMSCs, macrophages acquired an anti-inflammatory M2 phenotype characterized by an increased expression of mannose receptor (MR; CD206) and secretory cytokines interleukin (IL)-10 and IL-6, a suppressed production of tumor necrosis factor (TNF)-alpha, and decreased ability to induce Th-17 cell expansion. gmscs 21-26 interleukin 6 Homo sapiens 204-208 20715974-0 2010 Magnesium sulfate normalizes placental interleukin-6 secretion in preeclampsia. Magnesium Sulfate 0-17 interleukin 6 Homo sapiens 39-52 20715974-8 2010 However, exposure of preeclamptic placentas to MgSO(4) resulted in decreased IL-6 levels in the maternal circulations (1.7 +- 0.3 pg/mL/g cotyledon), when compared with the control group (P < 0.05). Magnesium Sulfate 47-54 interleukin 6 Homo sapiens 77-81 16418198-2 2006 The anti-rheumatic drug chloroquine has been shown to inhibit TNF-alpha, IL-1 and IL-6 production from mononuclear phagocytes. Chloroquine 24-35 interleukin 6 Homo sapiens 82-86 20598594-8 2010 The concentration of IL-6 was significantly higher in the OSCC group (mean 20.1+/-36.3 pg/mL) than in the control subjects (0.6+/-0.8 pg/mL; P=.003). oscc 58-62 interleukin 6 Homo sapiens 21-25 19086502-11 2007 Furosemide caused a dose dependent decrease in IL-6 (421 +/- 31, 534 +/- 33 vs. 662 +/- 41 pg mL(-1) p < 0.05). Furosemide 0-10 interleukin 6 Homo sapiens 47-51 16418198-9 2006 In contrast, chloroquine-induced inhibition of IL-1beta and IL-6 release was accompanied by a decrease in their steady-state mRNA levels. Chloroquine 13-24 interleukin 6 Homo sapiens 60-64 16418198-10 2006 The transcription rates of the IL-1beta and IL-6 genes were not changed by chloroquine, whereas the stability of IL-1beta and IL-6 mRNA was decreased by chloroquine. Chloroquine 153-164 interleukin 6 Homo sapiens 126-130 17341596-3 2007 We found that C-type natriuretic peptide and the NO donor Deta-NONOate induced IL-6 mRNA expression in primary human osteoblasts, an effect mimicked by the membrane-permeable cGMP analog 8-chlorophenylthio-cGMP (8-CPT-cGMP). 8-cpt 212-217 interleukin 6 Homo sapiens 79-83 20347984-2 2010 The aim of this study was to evaluate the effect in cell culture of the third generation DHP-CA Manidipine on the release of interleukin-6 (IL-6) and interleukin-8 (IL-8) from human endothelial cells and human macrophages, in response to different pro-inflammatory signals. dhp-ca manidipine 89-106 interleukin 6 Homo sapiens 125-138 20347984-2 2010 The aim of this study was to evaluate the effect in cell culture of the third generation DHP-CA Manidipine on the release of interleukin-6 (IL-6) and interleukin-8 (IL-8) from human endothelial cells and human macrophages, in response to different pro-inflammatory signals. dhp-ca manidipine 89-106 interleukin 6 Homo sapiens 140-144 16418198-12 2006 CONCLUSIONS: Our results indicate that chloroquine-mediated inhibition of TNF-alpha, IL-1beta and IL-6 synthesis occurs through different modes in lipopolysaccharide-stimulated human monocytes/macrophages: it blocks the conversion of cell-associated TNF-alpha precursor to mature soluble protein, whereas it reduces the levels of IL-1beta and IL-6 mRNA, at least in part, by decreasing their stability and by a pH-dependent mechanism. Chloroquine 39-50 interleukin 6 Homo sapiens 98-102 20603050-6 2010 Gene-gene analysis showed that a 3-factor model comprising the IL-6 C-174G, the IL-2 G-330T SNPs and the HLA-B*3501 allele was predictive for the occurrence of DUs in our population (testing accuracy=66.9%; p<0.0001, permutation testing). 2'-Deoxy-5'-O-Sulfouridine 160-163 interleukin 6 Homo sapiens 63-67 17652834-9 2007 Additionally, we found that baseline IL-6 levels were higher in: smokers as compared with nonsmokers (p < 0.001), patients with total cholesterol (TC) to high density lipoprotein (HDL)-cholesterol ratio (TC/HDL-ch ratio) above 5 as compared with subjects with TC/HDL-ch < or = 5 (p = 0.001), and in patients who did not report any statin therapy in comparison with patients undergoing statin treatment (p = 0.023). Technetium 150-152 interleukin 6 Homo sapiens 37-41 17652834-9 2007 Additionally, we found that baseline IL-6 levels were higher in: smokers as compared with nonsmokers (p < 0.001), patients with total cholesterol (TC) to high density lipoprotein (HDL)-cholesterol ratio (TC/HDL-ch ratio) above 5 as compared with subjects with TC/HDL-ch < or = 5 (p = 0.001), and in patients who did not report any statin therapy in comparison with patients undergoing statin treatment (p = 0.023). Technetium 207-209 interleukin 6 Homo sapiens 37-41 16418198-12 2006 CONCLUSIONS: Our results indicate that chloroquine-mediated inhibition of TNF-alpha, IL-1beta and IL-6 synthesis occurs through different modes in lipopolysaccharide-stimulated human monocytes/macrophages: it blocks the conversion of cell-associated TNF-alpha precursor to mature soluble protein, whereas it reduces the levels of IL-1beta and IL-6 mRNA, at least in part, by decreasing their stability and by a pH-dependent mechanism. Chloroquine 39-50 interleukin 6 Homo sapiens 343-347 20603050-7 2010 CONCLUSION: Biological interpretation via Petri net showed that IL-6 is a key factor in determining DUs occurrence and that this cytokines may synergise with HLA-B*3501 to determine DUs onset. 2'-Deoxy-5'-O-Sulfouridine 100-103 interleukin 6 Homo sapiens 64-68 16381797-3 2006 Because inositol-1,4,5-trisphosphate (IP(3))-mediated slow Ca(2+) signals evoked by depolarization of skeletal myotubes appears to play a role in the regulation of gene expression, we examined its involvement on IL-6 transcription. Inositol 1,4,5-Trisphosphate 8-36 interleukin 6 Homo sapiens 212-216 17031641-4 2007 NeuAc-TNFalpha reduced activities in the up-regulation of serum levels of IL-6 and NOx, but comparable activity as native TNFalpha in the down-regulation of the serum level of glucose. N-Acetylneuraminic Acid 0-5 interleukin 6 Homo sapiens 74-78 16381797-3 2006 Because inositol-1,4,5-trisphosphate (IP(3))-mediated slow Ca(2+) signals evoked by depolarization of skeletal myotubes appears to play a role in the regulation of gene expression, we examined its involvement on IL-6 transcription. Inositol 1,4,5-Trisphosphate 38-43 interleukin 6 Homo sapiens 212-216 16781858-4 2007 Pretreatment with 100 microM EPA and DHA significantly decreased lipopolysaccharide (LPS)-stimulated THP-1 macrophage tumor necrosis factor (TNF) alpha, interleukin (IL) 1beta and IL-6 production (P<.02), compared to control cells. Docosahexaenoic Acids 37-40 interleukin 6 Homo sapiens 180-184 20370329-7 2010 In vitro tests showed that, with the reduction of PTX release rates, PTX became more effective in inhibiting TNF-alpha and IL-6 production from activated macrophages. Pentoxifylline 50-53 interleukin 6 Homo sapiens 123-127 16381797-5 2006 Inhibitors of IP(3)-dependent Ca(2+) signals, like 2-aminoethoxydiphenyl borate (2-APB) and U-73122, decreased activation of IL-6 gene expression as did Ca(2+) signals inhibitor BAPTA-AM, whereas ryanodine, a fast Ca(2+) transient inhibitor, had no effect on IL-6 induction. Inositol 1,4,5-Trisphosphate 14-19 interleukin 6 Homo sapiens 125-129 20370329-7 2010 In vitro tests showed that, with the reduction of PTX release rates, PTX became more effective in inhibiting TNF-alpha and IL-6 production from activated macrophages. Pentoxifylline 69-72 interleukin 6 Homo sapiens 123-127 16381797-5 2006 Inhibitors of IP(3)-dependent Ca(2+) signals, like 2-aminoethoxydiphenyl borate (2-APB) and U-73122, decreased activation of IL-6 gene expression as did Ca(2+) signals inhibitor BAPTA-AM, whereas ryanodine, a fast Ca(2+) transient inhibitor, had no effect on IL-6 induction. Inositol 1,4,5-Trisphosphate 14-19 interleukin 6 Homo sapiens 259-263 20200221-8 2010 Exposure to 4-OPA significantly elevated IL-8, IL-6, GM-CSF, and TNF-alpha while glutaraldehyde caused significant elevations in IL-6, IL-8, and TNF-alpha. Glutaral 81-95 interleukin 6 Homo sapiens 129-133 17090648-1 2007 Chaetocin, a thiodioxopiperazine natural product previously unreported to have anticancer effects, was found to have potent antimyeloma activity in IL-6-dependent and -independent myeloma cell lines in freshly collected sorted and unsorted patient CD138(+) myeloma cells and in vivo. chaetocin 0-9 interleukin 6 Homo sapiens 148-152 16381797-8 2006 Our results provide evidence for involvement of IP(3)-mediated Ca(2+) signals on IL-6 transcription in skeletal muscle cells. Inositol 1,4,5-Trisphosphate 48-53 interleukin 6 Homo sapiens 81-85 16683059-7 2006 Treatment with glucocorticoids together with DETA-NO 1 hr pre and 4 hr post BPDOE-CDLs reduced serum amylase, lipase, C-reactive protein, IL-6, IL-10, hsp72, and 8-isoprostane as well as pancreatic and lung myeloperoxidase. 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene 45-52 interleukin 6 Homo sapiens 138-142 17097222-0 2007 Sulfatide increases adiponectin and decreases TNF-alpha, IL-6, and IL-8 in human adipose tissue in vitro. Sulfoglycosphingolipids 0-9 interleukin 6 Homo sapiens 57-61 21049628-17 2010 CONCLUSION: The serum concentrations of TNF-alpha, IL-6, D-Di and PLC level were significantly increased in peroperative period, These results seem to indicate that the Tong Mai Decoctions & Lornoxicam may play an important role in inhibiting the release of TNF-alpha, IL-6, D-Di and PLC into the blood stream and decreasing the incunabula complication at early traumatic stage. lornoxicam 195-205 interleukin 6 Homo sapiens 51-55 21049628-17 2010 CONCLUSION: The serum concentrations of TNF-alpha, IL-6, D-Di and PLC level were significantly increased in peroperative period, These results seem to indicate that the Tong Mai Decoctions & Lornoxicam may play an important role in inhibiting the release of TNF-alpha, IL-6, D-Di and PLC into the blood stream and decreasing the incunabula complication at early traumatic stage. lornoxicam 195-205 interleukin 6 Homo sapiens 273-277 20482831-0 2010 Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1beta, TNF-alpha and IL-6 in an in-vitro model of brain inflammation. Dimethyl Fumarate 0-16 interleukin 6 Homo sapiens 135-139 16343471-12 2006 CONCLUSIONS: 6 weeks after pravastatin therapy could significant modify the lipid profile and decrease the inflammatory markers including CRP and IL-6 in patients with hyperlididemia. Pravastatin 27-38 interleukin 6 Homo sapiens 146-150 20191310-9 2010 Furthermore, in vitro tests showed that when PTX was slowly released from the scaffolds, it became more effective in suppressing the production of TNF-alpha and IL-6 by stimulated macrophage cells. Pentoxifylline 45-48 interleukin 6 Homo sapiens 161-165 20157051-6 2010 AT(2) receptor-coupled signaling leading to reduced interleukin 6 levels involved inhibition of nuclear factor kappaB, activation of protein phosphatases, and synthesis of epoxyeicosatrienoic acid. epoxyeicosatrienoic acid 172-196 interleukin 6 Homo sapiens 52-65 17243915-4 2007 The aim of this study was to investigate whether plasma concentrations of interleukin-6, interleukin-8, C-reactive protein, and monocyte chemoattractant protein-1 are increased with higher plasma homocysteine concentrations and whether decreasing homocysteine by vitamin supplementation decreases the concentration of these markers. Homocysteine 196-208 interleukin 6 Homo sapiens 74-87 17723764-0 2006 Flow-injection immuno-bioassay for interleukin-6 in humans based on gold nanoparticles modified screen-printed graphite electrodes. Graphite 111-119 interleukin 6 Homo sapiens 35-48 17723764-2 2006 The immunosensor was prepared by entrapping horseradish peroxidase (HRP)-labeled IL-6 antibody into gold nanoparticles-modified composite membrane at a screen-printed graphite electrode. Graphite 167-175 interleukin 6 Homo sapiens 81-85 16511915-9 2006 These effects of simvastatin on IL-6 and IL-8 production and cell proliferation were reversed in the presence of mevalonic acid or geranylgeranyl-pyrophosphate, but not with farnesyl-pyrophosphate. Mevalonic Acid 113-127 interleukin 6 Homo sapiens 32-36 16220550-6 2006 In the present study, we report that tetracycline and minocycline dose-dependently reduce TNF-alpha and IL-6 release by adult human microglia upon stimulation with a combination of Abeta, SAP, and C1q. Tetracycline 37-49 interleukin 6 Homo sapiens 104-108 17109502-10 2006 The biliary IL-6 and TNF-alpha levels were positively correlated with serum DBIL, TBA and gamma-GT levels in IHS subjects. dbil 76-80 interleukin 6 Homo sapiens 12-16 17153635-6 2006 Both TRD and TRD-Cl, more effectively than TauCl, inhibited the production of IL-6 by stimulated macrophages. taurolidine 5-8 interleukin 6 Homo sapiens 78-82 19002880-6 2006 Specific production rates of interleukin-6 (IL-6) and tumor necrosis factor (TNF-alpha) from T cell were higher as 1.16 x 10(-4) and 1.86 x 10(-4 )pg/cell, respectively, in the purified compound, compared to 1.38 x 10(-4) and 2.22 x 10(-4 )pg/cell, respectively, by adding 0.5 g/L of the dichloromethane fraction. Methylene Chloride 288-303 interleukin 6 Homo sapiens 29-42 19002880-6 2006 Specific production rates of interleukin-6 (IL-6) and tumor necrosis factor (TNF-alpha) from T cell were higher as 1.16 x 10(-4) and 1.86 x 10(-4 )pg/cell, respectively, in the purified compound, compared to 1.38 x 10(-4) and 2.22 x 10(-4 )pg/cell, respectively, by adding 0.5 g/L of the dichloromethane fraction. Methylene Chloride 288-303 interleukin 6 Homo sapiens 44-48 19919624-10 2010 tumor necrosis factor-alpha (P < 0.04) and IL-8 were less (P < 0.001) in the plasma from the PVS group, while IL-6 and IL-8 were less (P < 0.04) in the lung tissue from ventilated lungs in the PVS group. 2-(phenylsulfonyl)ethanethiol 99-102 interleukin 6 Homo sapiens 116-120 20118567-8 2010 Nifedipine inhibited production of IL-1alpha, IL-6, and IFN-gamma. Nifedipine 0-10 interleukin 6 Homo sapiens 46-50 16306311-6 2006 Participants with the highest serum levels of alpha-carotene, total carotenoids, and selenium were significantly less likely to be in the highest tertile of serum IL-6 at baseline (p < 0.0001). Selenium 85-93 interleukin 6 Homo sapiens 163-167 16803639-6 2006 RGD-targeted adenovirus delivered the dnIkappaB via alphavbeta3 to become functionally expressed, leading to complete abolishment of TNF-alpha-induced up-regulation of E-selectin, ICAM-1, VCAM-1, IL-6, IL-8, VEGF-A and Tie-2. dnikappab 38-47 interleukin 6 Homo sapiens 196-200 21175000-4 2010 Results showed that PCB77 induced the expression of proinflammatory cytokines including IL-6 and TNFalpha and induced U937 adhesion to HUVEC cells consistent with increased NFkappaB transcription activity. 3,4,3',4'-tetrachlorobiphenyl 20-25 interleukin 6 Homo sapiens 88-92 21175000-6 2010 In conclusion, PCB77 showed the potential to induce the expression of proinflammatory cytokines including IL-6, which has been shown to be powerful independent risk predictor of CVD. 3,4,3',4'-tetrachlorobiphenyl 15-20 interleukin 6 Homo sapiens 106-110 17112855-1 2006 Pentoxifylline (PTX) is a nonselective phosphodiesterase inhibitor that inhibits the production of TNFalpha and IL6 and IL-10 cytokines. Pentoxifylline 0-14 interleukin 6 Homo sapiens 112-115 17112855-1 2006 Pentoxifylline (PTX) is a nonselective phosphodiesterase inhibitor that inhibits the production of TNFalpha and IL6 and IL-10 cytokines. Pentoxifylline 16-19 interleukin 6 Homo sapiens 112-115 16526817-8 2006 Treating PPG with glinides improves IMT as well as interleukin-6 and C-reactive protein levels, while treating PPG with rapid-acting insulin analogues is also associated with improvements in endothelial dysfunction. ppg 9-12 interleukin 6 Homo sapiens 51-64 17066155-7 2006 The level of IL-6 peaked on admission day in both groups, but in patients with SABP, the obtained values were higher. sabp 79-83 interleukin 6 Homo sapiens 13-17 17066155-12 2006 The most consistent difference between the two groups was that the levels of IL-6 were significantly higher in patients with SABP throughout the study. sabp 125-129 interleukin 6 Homo sapiens 77-81 19474802-6 2009 Treatment with cis-UCA increased prostaglandin E(2) (PGE(2)), tumor necrosis factor-alpha (TNF-alpha), and IL-6 secretion, whereas 5-HT only stimulated IL-6 production. cis-Urocanic acid 15-22 interleukin 6 Homo sapiens 107-111 17160447-14 2006 In Conclusion, in our pre-dialysis elderly patients, markers of a poor nutritional status (SGA and albumin) and inflammation (IL-6 and TNF-alpha) independently predicted the use of higher doses of darbepoietin to correct anaemia. darbepoietin 197-209 interleukin 6 Homo sapiens 126-130 19474802-6 2009 Treatment with cis-UCA increased prostaglandin E(2) (PGE(2)), tumor necrosis factor-alpha (TNF-alpha), and IL-6 secretion, whereas 5-HT only stimulated IL-6 production. cis-Urocanic acid 15-22 interleukin 6 Homo sapiens 152-156 19753313-0 2009 Cis-urocanic acid suppresses UV-B-induced interleukin-6 and -8 secretion and cytotoxicity in human corneal and conjunctival epithelial cells in vitro. cis-Urocanic acid 0-17 interleukin 6 Homo sapiens 42-62 19753313-9 2009 Treatment with 100 microg/ml cis-UCA completely suppressed IL-6 and IL-8 secretion, decreased caspase-3 activity, and improved cell viability against UV-B irradiation. cis-Urocanic acid 29-36 interleukin 6 Homo sapiens 59-63 17197726-5 2006 However, aziridine 2 had no effect on the resting lymphocyte proliferation in the absence of mitogens, at any concentration used, reduced Con A-stimulated T lymphocyte proliferation and LPS- stimulated B lymphocyte proliferation in a dose dependent manner and diminished IL-2 and IL-6 production. aziridine 2 9-20 interleukin 6 Homo sapiens 280-284 16386181-4 2005 RESULTS: Both APACHE II and IL-6 levels in LMWH group decreased with passage of time, the differences were significant between the results on day 7 and that of pretreatment (both P<0.05). Heparin, Low-Molecular-Weight 43-47 interleukin 6 Homo sapiens 28-32 16949834-9 2006 These results are possibly attributable to the inhibitory effect of IL6 on deiodination of T(3) and imply a role for IL6 in determining thyroxine replacement dose among these patients. Triiodothyronine 91-95 interleukin 6 Homo sapiens 68-71 17144099-12 2006 The tubular expressions of mRNA for IL-6 and TGF-gamma 1 in biopsies with acute rejection obtained from patients treated with MMF were significantly lower than in biopsies obtained from patients treated with azathioprine. Azathioprine 208-220 interleukin 6 Homo sapiens 36-40 16364386-5 2006 Significantly increased IL-6 and IL-1beta intracellular protein and mRNA expression was also observed in PBMC treated with DON (500 ng/ml) which were also partially p38-dependent. deoxynivalenol 123-126 interleukin 6 Homo sapiens 24-28 19655189-6 2009 10 mcirog/ml of TRF and all tocotrienol isoforms significantly inhibited the production of interleukin-6 and nitric oxide. Tocotrienols 28-39 interleukin 6 Homo sapiens 91-104 19523965-5 2009 Repetitive adult exposure to the NMDA-R antagonist ketamine increases the levels of the proinflammatory cytokine interleukin-6 in brain which, through activation of the superoxide-producing enzyme NADPH oxidase (Nox2), leads to the loss of the GABAergic phenotype of PV-interneurons and to decreased inhibitory activity in prefrontal cortex. Ketamine 51-59 interleukin 6 Homo sapiens 113-126 16155293-1 2005 We previously demonstrated that trans-10, cis-12 conjugated linoleic acid (CLA) reduced the triglyceride content of human adipocytes by activating mitogen-activated protein kinase kinase/extracellular signal-related kinase (MEK/ERK) signaling via interleukins (IL) 6 and 8. Linoleic Acids, Conjugated 75-78 interleukin 6 Homo sapiens 247-272 19465513-7 2009 TNFalpha-induced eotaxin, RANTES, and IL-6 as well as PDGF-BB-induced IL-6 expression was inhibited by DMF and by dexamethasone from asthmatic and nonasthmatic ASMC, but the combination of both drugs showed no glucocorticoid sparing effect in either of the two groups. Dimethyl Fumarate 103-106 interleukin 6 Homo sapiens 38-42 16793604-11 2006 Ketamine can inhibit the production of TNF-alpha and IL-6 but not IL-10. Ketamine 0-8 interleukin 6 Homo sapiens 53-57 16371321-8 2005 Freshly dissolved Abeta(1-40) (5-60 microM) resulted in a dose-dependent decrease in cell viability, along with a dose-dependent increase in IL-6 release. UNII-042A8N37WH 18-23 interleukin 6 Homo sapiens 141-145 16616662-7 2006 Both ketamine doses decreased the serum IL-6 response at ICU arrival and POD 1 compared with placebo (p < 0.05). Ketamine 5-13 interleukin 6 Homo sapiens 40-44 16616662-11 2006 CONCLUSION: Low-dose ketamine (0.5 mg/kg) attenuates increases in CRP, IL-6, and IL-10 while decreasing vasodilatation after CPB. Ketamine 21-29 interleukin 6 Homo sapiens 71-75 19465513-7 2009 TNFalpha-induced eotaxin, RANTES, and IL-6 as well as PDGF-BB-induced IL-6 expression was inhibited by DMF and by dexamethasone from asthmatic and nonasthmatic ASMC, but the combination of both drugs showed no glucocorticoid sparing effect in either of the two groups. Dimethyl Fumarate 103-106 interleukin 6 Homo sapiens 70-74 19185299-4 2009 METHODS: Cross-sectional associations of C-reactive protein (CRP) and Interleukin-6 (Il-6) with docosahexaenoic acid (DHA) and eicosapentaenoic acid (EHA) were evaluated in multivariable linear regression models adjusted for demographics, cardiovascular risk factors, medication use, exercise capacity, body-mass index, and waist-to-hip ratio. Docosahexaenoic Acids 96-116 interleukin 6 Homo sapiens 70-83 19185299-4 2009 METHODS: Cross-sectional associations of C-reactive protein (CRP) and Interleukin-6 (Il-6) with docosahexaenoic acid (DHA) and eicosapentaenoic acid (EHA) were evaluated in multivariable linear regression models adjusted for demographics, cardiovascular risk factors, medication use, exercise capacity, body-mass index, and waist-to-hip ratio. Docosahexaenoic Acids 96-116 interleukin 6 Homo sapiens 85-89 19185299-4 2009 METHODS: Cross-sectional associations of C-reactive protein (CRP) and Interleukin-6 (Il-6) with docosahexaenoic acid (DHA) and eicosapentaenoic acid (EHA) were evaluated in multivariable linear regression models adjusted for demographics, cardiovascular risk factors, medication use, exercise capacity, body-mass index, and waist-to-hip ratio. Docosahexaenoic Acids 118-121 interleukin 6 Homo sapiens 70-83 16175498-6 2005 In addition the proinflammatory cytokine, IL-6 is also activated, probably via catecholamines. Catecholamines 79-93 interleukin 6 Homo sapiens 42-46 19185299-4 2009 METHODS: Cross-sectional associations of C-reactive protein (CRP) and Interleukin-6 (Il-6) with docosahexaenoic acid (DHA) and eicosapentaenoic acid (EHA) were evaluated in multivariable linear regression models adjusted for demographics, cardiovascular risk factors, medication use, exercise capacity, body-mass index, and waist-to-hip ratio. Docosahexaenoic Acids 118-121 interleukin 6 Homo sapiens 85-89 19185299-4 2009 METHODS: Cross-sectional associations of C-reactive protein (CRP) and Interleukin-6 (Il-6) with docosahexaenoic acid (DHA) and eicosapentaenoic acid (EHA) were evaluated in multivariable linear regression models adjusted for demographics, cardiovascular risk factors, medication use, exercise capacity, body-mass index, and waist-to-hip ratio. eha 150-153 interleukin 6 Homo sapiens 70-83 19185299-4 2009 METHODS: Cross-sectional associations of C-reactive protein (CRP) and Interleukin-6 (Il-6) with docosahexaenoic acid (DHA) and eicosapentaenoic acid (EHA) were evaluated in multivariable linear regression models adjusted for demographics, cardiovascular risk factors, medication use, exercise capacity, body-mass index, and waist-to-hip ratio. eha 150-153 interleukin 6 Homo sapiens 85-89 19185299-5 2009 RESULTS: After multivariable adjustment, n-3 fatty acid levels (DHA+EPA) were inversely associated with CRP and IL-6. Docosahexaenoic Acids 64-67 interleukin 6 Homo sapiens 112-116 16434692-7 2006 In contrast, LMW-APM reduces LPS-mediated IL-6 release and furthermore, stimulates IL-10 secretion, most likely by reducing the abundance of inhibitor of nuclear factor (NF)-kappaB kinase beta, leading to a diminished nuclear translocation of NF-kappaB p65. lmw-apm 13-20 interleukin 6 Homo sapiens 42-46 16708557-12 2005 We suggest that -174 IL-6 promoter polymorphism may be a genetic risk factor determining the effectiveness of RA treatement with methotrexate and glucocorticosteroids. glucocorticosteroids 146-166 interleukin 6 Homo sapiens 21-25 16499573-10 2006 We also observed that throughout C. trachomatis persistence induced by doxycycline (Dox) treatment, IL-1beta, IL-6, IL-8 and TNF-alpha expression was reduced, whereas the synthesis of IL-10 and IL-12p70 remained unchanged but not sustained. Doxycycline 84-87 interleukin 6 Homo sapiens 110-114 16111494-5 2005 Indomethacin, a common nonsteroidal anti-inflammatory drug (NSAID), had no effect on microglial chemotaxis or phagocytosis, but did significantly inhibit the enhanced production of IL-6 after Abeta opsonization. Indomethacin 0-12 interleukin 6 Homo sapiens 181-185 16234304-5 2006 Adjusting for age, sex, and major confounders, lower arachidonic and docosahexaenoic acids were associated with significantly higher IL-6 and IL-1ra and significantly lower TGFbeta. Docosahexaenoic Acids 69-90 interleukin 6 Homo sapiens 133-137 17192125-6 2006 In the EUTOPIA (EUropean Trial on Olmesartan and Pravastatin in Inflammation and Atherosclerosis) trial, olmesartan medoxomil significantly reduced serum levels of high-sensitivity C-reactive protein, high-sensitivity TNFalpha, IL-6, and MCP-1, all of which are involved in promoting atherosclerosis. olmesartan 105-115 interleukin 6 Homo sapiens 228-232 19953908-6 2009 ROK inhibitor Y27632 reduced the secretion of TNFalpha, IL-1beta and IL-6 in RA SF monocytic cells, but had no effect upon the secretion of IL-10, an anti-inflammatory cytokine. Y 27632 14-20 interleukin 6 Homo sapiens 69-73 19468304-8 2009 Studies conducted with pentoxifylline and neutralizing antibodies revealed that the Leishmania-dependent augmentation in HIV-1 replication is due to a higher secretion of IL-6 and TNF-alpha. Pentoxifylline 23-37 interleukin 6 Homo sapiens 171-175 17192125-6 2006 In the EUTOPIA (EUropean Trial on Olmesartan and Pravastatin in Inflammation and Atherosclerosis) trial, olmesartan medoxomil significantly reduced serum levels of high-sensitivity C-reactive protein, high-sensitivity TNFalpha, IL-6, and MCP-1, all of which are involved in promoting atherosclerosis. medoxomil 116-125 interleukin 6 Homo sapiens 228-232 15854645-5 2005 The induction of TNF-alpha, IL-6 and interferon alpha (IFN-alpha) was chloroquine-sensitive and dependent more likely on endosomal Toll-like receptor signaling in particular TLR8. Chloroquine 70-81 interleukin 6 Homo sapiens 28-32 17042956-8 2006 Upon examination of signaling pathways involved in PGE2 and IL-6 production, we found that HNE-induced PGE2 release was abrogated by SB202190, a p38 mitogen-activated protein kinase (MAPK) inhibitor. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 133-141 interleukin 6 Homo sapiens 60-64 19211919-6 2009 cAMP-responsive element-binding protein (CREB) might be involved in ERK1/2-induced IL-6 expression because phosphorylation of CREB was observed after angiotensin II treatment, which was reversed by losartan and the ERK1/2 inhibitor. Losartan 198-206 interleukin 6 Homo sapiens 83-87 15850408-4 2005 Pravastatin inhibited the overproduction of monocyte chemoattractant protein 1, IL6 and IL8 and the enhanced expression of intercellular adhesion molecule 1 but had no effect on platelet-endothelial cell adhesion molecule 1 expression. Pravastatin 0-11 interleukin 6 Homo sapiens 80-83 19126823-7 2009 DISCUSSION: We postulate that the elevation in CRP levels and the subsequent fever were caused by the effects of clozapine on the cytokine system via interleukin-6 and tumor necrosis factor-alpha, resulting in an inflammatory response with an acute phase reaction. Clozapine 113-122 interleukin 6 Homo sapiens 150-195 19439980-9 2009 RESULTS: Budesonide inhibited the release of TNF-alpha, IL-6 and IL-8 from sPLA(2)-stimulated macrophages in a concentration-dependent manner. Budesonide 9-19 interleukin 6 Homo sapiens 56-60 16464786-5 2006 The aim of this study was to investigate whether individuals with increased plasma homocysteine concentrations have altered levels of serum CRP and IL-6. Homocysteine 83-95 interleukin 6 Homo sapiens 148-152 16464786-11 2006 CONCLUSIONS: These data suggest that enhanced inflammation may be associated with homocysteine-related cardiovascular disease, possibly involving IL-6-related mechanisms. Homocysteine 82-94 interleukin 6 Homo sapiens 146-150 16286017-2 2005 Here, we showed that IL-6-STAT3 signaling reduced intracellular MHCII alphabeta dimmer, Ii, and H2-DM levels in DCs. h2-dm 96-101 interleukin 6 Homo sapiens 21-25 16286017-4 2005 Importantly, cathepsin S inhibitors blocked reduction of MHCII alphabeta dimer, Ii, and H2-DM in the IL-6-treated DCs. h2-dm 88-93 interleukin 6 Homo sapiens 101-105 15713433-7 2005 TNF-alpha, IL-1beta, and IL-6 released from splenocytes collected 2 weeks after TFA-S100 inoculation were increased resembling the elevated serum cytokines reported in patients with autoimmune hepatitis (AIH). Trifluoroacetic Acid 80-83 interleukin 6 Homo sapiens 25-29 16286017-5 2005 Overexpression of cystatin C suppressed IL-6-STAT3-mediated increase of cathepsin S activity and reduction of MHCII alphabeta dimer, Ii, and H2-DM levels in DCs. h2-dm 141-146 interleukin 6 Homo sapiens 40-44 16286017-8 2005 Thus, IL-6-STAT3-mediated increase of cathepsin S activity reduces the MHCII alphabeta dimer, Ii, and H2-DM levels in DCs, and suppresses CD4(+) T cell-mediated immune responses. h2-dm 102-107 interleukin 6 Homo sapiens 6-10 19249543-12 2009 There were significantly lower tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, interferon (IFN)-gamma, IL-6, and MIP-1beta productions from the OptiPrep-based density gradient group. iodixanol 155-163 interleukin 6 Homo sapiens 114-118 15652404-2 2005 Abeta(1-42) (5 microM) applied for 8 h induced the expression and increased the production of the pro-inflammatory cytokines IL-6, IL-1beta, TNF-alpha, the inducible enzyme COX-2 and chemokine IL-8. UNII-042A8N37WH 0-5 interleukin 6 Homo sapiens 125-129 19890745-8 2009 We demonstrated significant reduction (P < 0.05) in levels of procalcitonin and interleukin-6 in the preoperative clonidine group compared with the preoperative levobupivacaine and control groups. Clonidine 117-126 interleukin 6 Homo sapiens 83-96 16091484-2 2005 In vitro DHEA has been shown to enhance IL-2 release from T lymphocytes, whereas it inhibits IL-6 secretion. Dehydroepiandrosterone 9-13 interleukin 6 Homo sapiens 93-97 16155367-9 2005 The two new PPAR-gamma agonists and 15d-PGJ2 also inhibited TNF-alpha-induced interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) production in supernatants of TNF-alpha-stimulated ECs, whereas ciglitazone and DIM-C-pPhCH(3) did not decrease TNF-alpha-induced expression of these two proteins. 15-deoxy-delta(12,14)-prostaglandin J2 36-44 interleukin 6 Homo sapiens 78-91 16155367-9 2005 The two new PPAR-gamma agonists and 15d-PGJ2 also inhibited TNF-alpha-induced interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) production in supernatants of TNF-alpha-stimulated ECs, whereas ciglitazone and DIM-C-pPhCH(3) did not decrease TNF-alpha-induced expression of these two proteins. 15-deoxy-delta(12,14)-prostaglandin J2 36-44 interleukin 6 Homo sapiens 93-97 15606619-5 2005 We show that by inhibiting the mevalonate pathway, nBPs induce rapid and copious production of TNFalpha and IL6 by peripheral blood gammadelta T cells. Mevalonic Acid 31-41 interleukin 6 Homo sapiens 108-111 16169525-4 2005 In addition, LA, ALA, and DHA decreased IL-6, IL-1beta, and TNFalpha gene expression (P < 0.05 for all) and nuclear factor (NF)-kappaB DNA-binding activity, whereas peroxisome proliferator-activated receptor-gamma (PPARgamma) DNA-binding activity was increased. Docosahexaenoic Acids 26-29 interleukin 6 Homo sapiens 40-44 16273650-7 2005 IL-6 concentrations were significantly lower on the 6(th) postoperative day in the Ala-Gln group than those in the Conv group in patients with APACHE II <=6, whereas no difference was noted in patients with APACHE II >6. alanylglutamine 83-90 interleukin 6 Homo sapiens 0-4 16273650-10 2005 A significant inverse correlation was noted between plasma IL-6 levels and cumulative nitrogen balance postoperatively in the Ala-Gln group, whereas no such correlation was observed in the Conv group. alanylglutamine 126-133 interleukin 6 Homo sapiens 59-63 18583119-0 2008 Novel leads from Heliotropium ovalifolium, 4,7,8-trimethoxy-naphthalene-2-carboxylic acid and 6-hydroxy-5,7-dimethoxy-naphthalene-2-carbaldehyde show specific IL-6 inhibitory activity in THP-1 cells and primary human monocytes. 6-hydroxy-5,7-dimethoxy-naphthalene-2-carbaldehyde 94-144 interleukin 6 Homo sapiens 159-163 18583119-5 2008 Bioassay guided fractionation identified two compounds 4,7,8-trimethoxy-naphthalene-2-carboxylic acid and 6-hydroxy-5,7-dimethoxy-naphthalene-2-carbaldehyde with an IC(50) of 2.4 and 2.0 microM for IL-6 inhibition and an IC(50) of 15.6 and 7.0 microM for tumor necrosis factor-alpha (TNF-alpha) inhibition in THP-1 cells. 6-hydroxy-5,7-dimethoxy-naphthalene-2-carbaldehyde 106-156 interleukin 6 Homo sapiens 198-202 19016938-8 2008 Adjusted mean IL-6 at month 12 was 8.5% (0.21 pg/mL) higher in the SA than the PA group. sa 67-69 interleukin 6 Homo sapiens 14-18 15528032-2 2004 We examined the hypothesis that 17beta-estradiol and trivalent chromium inhibit secretion of the pro-inflammatory cytokine interleukin (IL)-6 and oxidative stress in monocytes exposed to high glucose (HG). Chromium 63-71 interleukin 6 Homo sapiens 123-141 18502114-2 2008 The biosensors operating at 747.7 MHz and 1.586 GHz were functionalized by immobilizing the monoclonal IL-6 antibody onto the ZnO biosensor surface both through direct surface adsorption and through covalent binding on gluteraldehyde. Glutaral 219-233 interleukin 6 Homo sapiens 103-107 16223437-5 2005 Additionally, the IL-6 and mPGES levels rose with the increase of HCY in a dose-dependent manner (p<0.01 and p<0.05, respectively). Homocysteine 66-69 interleukin 6 Homo sapiens 18-22 16223437-7 2005 In conclusion, HCY can increase the expression of IL-6 and mPGES, while PPAR-gamma activator can inhibit the increase of IL-6 and mPGES induced by HCY. Homocysteine 15-18 interleukin 6 Homo sapiens 50-54 16223437-7 2005 In conclusion, HCY can increase the expression of IL-6 and mPGES, while PPAR-gamma activator can inhibit the increase of IL-6 and mPGES induced by HCY. Homocysteine 147-150 interleukin 6 Homo sapiens 121-125 18937599-2 2008 Oxalate and other stone precursors have been shown to increase IL-6 production in proximal tubular epithelial cells in vitro. Oxalates 0-7 interleukin 6 Homo sapiens 63-67 15528032-7 2004 Thus, 17beta-estradiol+Cr(3+) inhibits oxidative stress, IL-6 secretion, and monocytic adhesion to endothelial cells, risk factors in the development of heart disease. Chromium 23-25 interleukin 6 Homo sapiens 57-61 15579764-0 2004 Raloxifene modulates interleukin-6 and tumor necrosis factor-alpha synthesis in vivo: results from a pilot clinical study. Raloxifene Hydrochloride 0-10 interleukin 6 Homo sapiens 21-66 18632990-4 2008 DHA-treated, mature DCs showed inhibition of IL-6 expression and IL-10 and IL-12 secretion, and their lymphoproliferative stimulation capacity was impaired. Docosahexaenoic Acids 0-3 interleukin 6 Homo sapiens 45-49 19967068-2 2008 In the present study, we found that specific tyrphostin inhibitors of ErbB2 (AG825 and AG879), but not ErbB1 inhibitor (AG1478), suppressed IL-6-induced tyrosine phosphorylation of STAT3 in schwannoma cells. tyrphostin AG825 77-82 interleukin 6 Homo sapiens 140-144 16002475-6 2005 Induction of IL-1alpha, IL-6, IL-11, and FGF-9 mRNA by MEP and benzo(a)pyrene was concentration and time dependent. Benzo(a)pyrene 63-77 interleukin 6 Homo sapiens 24-28 16002475-8 2005 Treatment with MEP or benzo(a)pyrene increased IL-6 and IL-11 releases to CL5 cell medium. Benzo(a)pyrene 22-36 interleukin 6 Homo sapiens 47-51 16145309-5 2005 In a minority of patients, estrogen-progestogen associations and tibolone increased IL-6 levels and induced unfavorable changes on inflammation markers (CRP: +93% +/- 8%, intracellular adhesion molecule: -3% +/- 2%, vascular cell adhesion molecule: -5% +/- 2%, E-selectin: +6% +/- 2%, s-thrombomodulin: +5% +/- 2%, IL-6: +12% +/- 4%; percent changes compared with baseline). tibolone 65-73 interleukin 6 Homo sapiens 315-319 15844657-8 2004 Previous studies have also shown that atiprimod treatment reduced production of IL-6, VEGF and inhibited activation of Stat3, a constitutively activated protein in majority of human cancers. azaspirane 38-47 interleukin 6 Homo sapiens 80-84 15717324-9 2005 In addition, the effects of IL-6 on cardiomyocyte hypertrophy and fibroblast proliferation were inhibited by addition of the AT-1 receptor antagonist, losartan. Losartan 151-159 interleukin 6 Homo sapiens 28-32 18482990-6 2008 Moreover, by combining a range of C. albicans glycosylation mutants with receptor-specific blocking and cytokine production assays, we determined that N-linked mannan but not O-linked or phosphomannan is the fungal carbohydrate structure specifically recognized by both C-type lectins on human DCs and directly influences the production of the proinflammatory cytokine IL-6. n-linked mannan 151-166 interleukin 6 Homo sapiens 369-373 15610530-9 2004 Treatment with AG490 (Janus tyrosine kinase [JAK] inhibitor) and LY294002 (PI3-Kinase inhibitor) inhibited IL-6-mediated upregulation of bFGF mRNA and protein secretion. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 15-20 interleukin 6 Homo sapiens 107-111 18341600-2 2008 This study aimed to investigate the effect of chlorhexidine (CHX) solution on circulating levels of lipopolysaccharide (LPS) and interleukin-6 (IL-6) when used as an irrigant during ultrasonic debridement in patients with periodontitis. Chlorhexidine 46-59 interleukin 6 Homo sapiens 129-142 18341600-2 2008 This study aimed to investigate the effect of chlorhexidine (CHX) solution on circulating levels of lipopolysaccharide (LPS) and interleukin-6 (IL-6) when used as an irrigant during ultrasonic debridement in patients with periodontitis. Chlorhexidine 46-59 interleukin 6 Homo sapiens 144-148 18341600-2 2008 This study aimed to investigate the effect of chlorhexidine (CHX) solution on circulating levels of lipopolysaccharide (LPS) and interleukin-6 (IL-6) when used as an irrigant during ultrasonic debridement in patients with periodontitis. Chlorhexidine 61-64 interleukin 6 Homo sapiens 129-142 18341600-2 2008 This study aimed to investigate the effect of chlorhexidine (CHX) solution on circulating levels of lipopolysaccharide (LPS) and interleukin-6 (IL-6) when used as an irrigant during ultrasonic debridement in patients with periodontitis. Chlorhexidine 61-64 interleukin 6 Homo sapiens 144-148 18400717-7 2008 RESULTS: In Caco-2 cells, IL-6 secretion was significantly decreased by troglitazone, DHA, EPA, and GLA. Docosahexaenoic Acids 86-89 interleukin 6 Homo sapiens 26-30 15762036-0 2004 Effects of 17beta-estradiol, tamoxifen and raloxifene on the protein and mRNA expression of interleukin-6, transforming growth factor-beta1 and insulin-like growth factor-1 in primary human osteoblast cultures. Raloxifene Hydrochloride 43-53 interleukin 6 Homo sapiens 92-105 18400717-7 2008 RESULTS: In Caco-2 cells, IL-6 secretion was significantly decreased by troglitazone, DHA, EPA, and GLA. gamma-Linolenic Acid 100-103 interleukin 6 Homo sapiens 26-30 18415826-5 2008 Budesonide attenuated the IL-6 and IL-8 release, an inhibiting effect that was sustained, but not reinforced, by formoterol. Budesonide 0-10 interleukin 6 Homo sapiens 26-30 15762036-6 2004 In conclusion, the effects of estradiol or tamoxifen on bone metabolism do not appear to be mediated through the regulation of osteoblast IL-6 release or synthesis, but raloxifene produces a decrease in mRNA IL-6 expression. Raloxifene Hydrochloride 169-179 interleukin 6 Homo sapiens 208-212 15115713-7 2004 RESULTS: Mean (SEM) serum levels of IFNgamma were significantly reduced after leflunomide treatment (baseline 43 (10) pg/ml; 1 year 29 (7) (p = 0.015), but there was no change in IL6 levels (baseline 158 (41), 1 year 151 (48)). Leflunomide 78-89 interleukin 6 Homo sapiens 179-182 18426661-7 2008 In addition, both hFOBs and BM-MSC expressed SCF, IL-6, and SDF-1alpha mRNA, but only hFOBs could express GM-CSF and G-CSF. hfobs 18-23 interleukin 6 Homo sapiens 50-54 15115713-11 2004 CONCLUSION: The differential effect on IFNgamma and IL6 production supports the hypothesis that activated T cells are preferentially inhibited by leflunomide. Leflunomide 146-157 interleukin 6 Homo sapiens 52-55 15159225-7 2004 Interleukin 6 concentrations were lower after consumption of the oleic acid diet than after consumption of the LMP, TFA, and STE diets. Oleic Acid 65-75 interleukin 6 Homo sapiens 0-13 18062909-6 2008 Thrombin-mediated IL-6 production was attenuated by thrombin inhibitor (PPACK), phospholipase C inhibitor (U73122), protein kinase C alpha inhibitor (Ro320432), Src inhibitor (PP2), NF-kappaB inhibitor (PDTC), I kappa B protease inhibitor (TPCK), or NF-kappaB inhibitor peptide. ro320432 150-158 interleukin 6 Homo sapiens 18-22 15159225-7 2004 Interleukin 6 concentrations were lower after consumption of the oleic acid diet than after consumption of the LMP, TFA, and STE diets. stearic acid 125-128 interleukin 6 Homo sapiens 0-13 18444445-7 2008 RESULTS: The pattern of postoperative secretion of the proinflammatory cytokines IL-1beta and IL-6 and that of the anti-inflammatory cytokine IL-10 differed significantly between patients receiving SDFA and those receiving IDFA and LDFA, but was similar between the last two groups. sdfa 198-202 interleukin 6 Homo sapiens 94-98 15109670-4 2004 A preliminary SAR study suggested that the hydrochloride of the CEFG-ring portion is an active pharmacophore for suppressing the growth of interleukin-6-dependent MH60 cells. cefg 64-68 interleukin 6 Homo sapiens 139-152 15010462-4 2004 Conversely, inhibition of Src family tyrosine kinases by the pyrazolopyrimidine PP2, as in kinase-inactive Hck mutants, significantly reduces IL-6-triggered activation of extracellular signal-regulated kinase and AKT-1, leading to significant reduction of multiple myeloma cell proliferation and survival. 1H-pyrazolo[4,3-d]pyrimidine 61-79 interleukin 6 Homo sapiens 142-146 18946510-6 2008 Applying a whole blood assay, IC(50) values of pro-inflammatory cytokine release (TNF-alpha, IL-6, IL-8, IL-1beta) were found to be positively correlated with the K(i)-values of the aforementioned polyphenols. Polyphenols 197-208 interleukin 6 Homo sapiens 93-97 17988365-0 2007 An imbalance in the production of IL-1beta and IL-6 by monocytes of bipolar patients: restoration by lithium treatment. Lithium 101-108 interleukin 6 Homo sapiens 47-51 14749354-6 2004 The induction by DHT or IL-6 or forskolin or their combinations was inhibited by antiandrogen, casodex, in a dose-dependent manner, indicating that a functional androgen receptor was required for the action of any of these three agents. bicalutamide 95-102 interleukin 6 Homo sapiens 24-28 17450584-10 2007 PGE2 and IL-6 secretion by fibroblasts have been significantly increased in the presence of Ti particles or SP. ti particles 92-104 interleukin 6 Homo sapiens 9-13 15041999-8 2004 Pretreatment of the ovarian cancer cells with the pertussis toxin completely inhibited lysophosphatidic acid-stimulated production of interleukin-6, interleukin-8 and tumor necrosis factor-alpha. lysophosphatidic acid 87-108 interleukin 6 Homo sapiens 134-147 14706622-6 2004 Western immunoblotting and indirect cellular immunofluorescence showed that indomethacin and ibuprofen induce Hsc70 nuclear translocation at concentrations previously shown to induce HSF DNA-binding activity. Indomethacin 76-88 interleukin 6 Homo sapiens 183-186 17681970-3 2007 We have assessed the effect of preoperative administration of a sub-anaesthetic dose of ketamine on the mitogen response and production of interleukin (IL)-1beta, IL-2, IL-6, and tumour necrosis factor (TNF)-alpha by peripheral blood mononuclear cells (PBMCs), as well as natural killer cell cytotoxicity (NKCC) in patients undergoing abdominal surgery. Ketamine 88-96 interleukin 6 Homo sapiens 169-173 17681970-8 2007 RESULTS: Four hours after operation, the cells from patients in the ketamine group showed a significantly suppressed production of IL-6 (P < 0.01) compared with controls. Ketamine 68-76 interleukin 6 Homo sapiens 131-135 17681970-11 2007 CONCLUSIONS: Addition of small doses of ketamine before induction of anaesthesia resulted in attenuation of secretion of the proinflammatory cytokines IL-6 and TNF-alpha, and in preservation of IL-2 production at its preoperative level. Ketamine 40-48 interleukin 6 Homo sapiens 151-155 15044820-7 2004 Supplementation with alfacalcidol significantly decreased serum concentration of sTNFR-II from 23.8 +/- 4.38 to 19.7 +/- 3.93 ng/ml (p < 0.001) but did not alter serum IL-6 concentration. alfacalcidol 21-33 interleukin 6 Homo sapiens 171-175 15581058-3 2004 The pathogenesis of AIDS-related KS is related to a system of cytokines (e.g., interleukin-6) driven by autocrine and paracrine loops. Potassium 33-35 interleukin 6 Homo sapiens 79-92 17178209-13 2007 Given its preliminary nature due to the limited available data, this quantitative review showed a positive association between cancer-related fatigue and circulating levels of IL-6, IL-1 ra and neopterin. Neopterin 194-203 interleukin 6 Homo sapiens 176-180 17346688-0 2007 Sodium selenite inhibits interleukin-6-mediated androgen receptor activation in prostate cancer cells via upregulation of c-Jun. Sodium Selenite 0-15 interleukin 6 Homo sapiens 25-38 17346688-4 2007 METHODS: Cell proliferation, prostate-specific antigen, gene transfer, and Western blot assays were used to study the effects of sodium selenite and methylseleninic acid on IL-6 mediated AR action on an AR expressing human prostate cancer cell line, LNCaP. Sodium Selenite 129-144 interleukin 6 Homo sapiens 173-177 17346688-5 2007 RESULTS: We found that sodium selenite, but not methylseleninic acid, significantly (p<0.05) inhibited IL-6-induced trans-activating activity of AR and cell proliferation in LNCaP cells. Sodium Selenite 23-38 interleukin 6 Homo sapiens 106-110 12955521-2 2004 Both circulating catecholamine levels and exercise intensity have been related to the exercise-derived IL-6. Catecholamines 17-30 interleukin 6 Homo sapiens 103-107 17346688-8 2007 CONCLUSIONS: Taken together, our results suggest that sodium selenite not methylseleninic acid can inhibit IL-6-mediated AR activation by increased c-Jun in LNCaP cells. Sodium Selenite 54-69 interleukin 6 Homo sapiens 107-111 17346688-9 2007 Sodium selenite may be a proper selenium form for further testing its potency on intervening IL-6-mediated PCa progression. Sodium Selenite 0-15 interleukin 6 Homo sapiens 93-97 12955521-4 2004 Therefore, hypoxia offers a unique opportunity to study the effect of catecholamines and intensity on exercise-derived IL-6. Catecholamines 70-84 interleukin 6 Homo sapiens 119-123 17062603-2 2007 Some of the macrophages appear to be enriched with free cholesterol (FCMphis), and we have shown that this process induces the synthesis and secretion of inflammatory cytokines, including TNF-alpha and IL-6. fcmphis 69-76 interleukin 6 Homo sapiens 202-206 14651779-0 2003 Fever after zoledronic acid administration is due to increase in TNF-alpha and IL-6. Zoledronic Acid 12-27 interleukin 6 Homo sapiens 79-83 17958722-9 2007 Serum NE activities and serum concentrations of IL-1beta, IL-6, and HMGB1 were significantly suppressed in the Sivelestat-treated group. sivelestat 111-121 interleukin 6 Homo sapiens 58-62 14651779-2 2003 The aim of this study was to define the role of the main cytokines of the acute-phase reaction interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) involved in the pathogenesis of zoledronic acid-induced fever. Zoledronic Acid 192-207 interleukin 6 Homo sapiens 95-108 14651779-2 2003 The aim of this study was to define the role of the main cytokines of the acute-phase reaction interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) involved in the pathogenesis of zoledronic acid-induced fever. Zoledronic Acid 192-207 interleukin 6 Homo sapiens 110-114 17710582-8 2007 There was a reduction in IL-10, TNF-alpha, and IL-6 production with increasing doses of clonidine and hydralazine by placentas in preeclampsia. Clonidine 88-97 interleukin 6 Homo sapiens 47-51 17710582-9 2007 IL-10, TNF-alpha, and IL-6 production from preeclamptic placenta and PBMCs were inhibited by diazoxide and furosemide. Furosemide 107-117 interleukin 6 Homo sapiens 22-26 14651779-7 2003 IL-6 levels increased significantly 1 day after the infusion (p = 0.007), returning to values similar to the median basal values 2 days after zoledronic acid administration. Zoledronic Acid 142-157 interleukin 6 Homo sapiens 0-4 14651779-10 2003 Our results show that zoledronic acid induces transient TNF-alpha and IL-6 increases and that these increases are higher in patients who have developed fever, suggesting that these cytokines could be responsible for fever pathogenesis. Zoledronic Acid 22-37 interleukin 6 Homo sapiens 70-74 13678786-8 2003 Conversely, wild-type cells respond to db-cAMP with a severalfold increase in magnitude and rate of IL-6 production, whereas mutant strains remain essentially unresponsive. Bucladesine 39-46 interleukin 6 Homo sapiens 100-104 17169411-9 2007 CRC patients had a positive correlation between IL-6 and CRP (r=0.7638, p<0.01) and between sP-selectin and IL-6 (r=0.5633, p<0.03). sp-selectin 95-106 interleukin 6 Homo sapiens 111-115 12888915-0 2003 IL-6 is a key factor in growth inhibition of human myeloma cells induced by pravastatin, an HMG-CoA reductase inhibitor. Pravastatin 76-87 interleukin 6 Homo sapiens 0-4 17161616-11 2006 Several pro-inflammatory/resorptive cytokines including IL-6, IL-4, IFN-gamma, macrophage inhibitory factor (MIF) were down-regulated not only by DEX but also by DHEA. Dehydroepiandrosterone 162-166 interleukin 6 Homo sapiens 56-60 12888915-7 2003 Indeed, rhIL-6 abolished pravastatin-induced growth inhibition in KMS-21BM cells which did not express IL-6. Pravastatin 25-36 interleukin 6 Homo sapiens 10-14 16896935-11 2006 CONCLUSIONS/INTERPRETATION: Homocysteine upregulates the MMP-TIMP pathway and IL6 release, the effect being stronger in the presence of high glucose. Homocysteine 28-40 interleukin 6 Homo sapiens 78-81 16896785-6 2006 The combination reduced IL-6 (from 7.93+/-1.9 to 5.59+/-1.2 pg/mL, p=0.008 vs. placebo and p=0.007 vs. amlodipine) and TC (from 4.3+/-0.5 to 3.6+/-0.4 mmol/L, p=0.008 vs. placebo and vs. amlodipine). Amlodipine 103-113 interleukin 6 Homo sapiens 24-28 12970288-0 2003 Raloxifene concurrently stimulates osteoprotegerin and inhibits interleukin-6 production by human trabecular osteoblasts. Raloxifene Hydrochloride 0-10 interleukin 6 Homo sapiens 64-77 12970288-9 2003 In addition, raloxifene inhibited expression of the bone-resorbing cytokine IL-6 by 25-45% (P < 0.001). Raloxifene Hydrochloride 13-23 interleukin 6 Homo sapiens 76-80 16790487-9 2006 Further computational and biochemical analyses show that cyfluthrin and chlorpyrifos upregulate certain targets of the interferon-gamma and insulin-signaling pathways and that they increase the protein levels of activated extracellular signal-regulated kinase 1/2, a key component of insulin signaling; interleukin 6, a key inflammatory mediator; and glial fibrillary acidic protein, a marker of inflammatory astrocyte activation. cyfluthrin 57-67 interleukin 6 Homo sapiens 303-316 12873450-8 2003 Baicalin did not suppress IL-1beta-induced IL-6 and IL-8 production, but dexamethasone, baicalein, and wogonin, significantly suppressed IL-6 and IL-8 production. baicalein 88-97 interleukin 6 Homo sapiens 137-141 16790487-9 2006 Further computational and biochemical analyses show that cyfluthrin and chlorpyrifos upregulate certain targets of the interferon-gamma and insulin-signaling pathways and that they increase the protein levels of activated extracellular signal-regulated kinase 1/2, a key component of insulin signaling; interleukin 6, a key inflammatory mediator; and glial fibrillary acidic protein, a marker of inflammatory astrocyte activation. Chlorpyrifos 72-84 interleukin 6 Homo sapiens 303-316 16793604-8 2006 The levels of TNF-alpha in ketamine group between T(2) and T(7) were significantly lower than that in the control group, and the IL-6 level between T(2) and T(5) were also significantly lower in ketamine group. Ketamine 195-203 interleukin 6 Homo sapiens 129-133 12807426-5 2003 We found that VPA dose-dependently inhibited SP-induced IL-6 synthesis which was seen with pre-incubation periods of 30 min, 3, 7 and 14 days, whereas carbamazepine and lithium showed no inhibitory effect. Valproic Acid 14-17 interleukin 6 Homo sapiens 56-60 16631683-8 2006 Subgroup analysis revealed a significantly greater elevation in IL-6, IL-8, and IL-10 levels in PGF patients (all p < 0.01) versus PLTRE. Prostaglandins F 96-99 interleukin 6 Homo sapiens 64-68 16631683-10 2006 CONCLUSIONS: Patients with PLTRE and PGF exhibited graded increases in IL-6, IL-8, and IL-10 concentrations. Prostaglandins F 37-40 interleukin 6 Homo sapiens 71-75 12801316-10 2003 Moreover, 10-5 M pranlukast and MK-571 inhibited LPS-induced IL-6 production in PBMC by about 65% and 15%, respectively. verlukast 32-38 interleukin 6 Homo sapiens 61-65 16520738-4 2006 Buddlejasaponin IV inhibited the LPS-induced activation of nuclear factor-kappaB (NF-kappaB), a transcription factor necessary for proinflammatory mediators, iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 expression. buddlejasaponin 0-15 interleukin 6 Homo sapiens 195-199 12818406-0 2003 Dietary alpha-linolenic acid decreases C-reactive protein, serum amyloid A and interleukin-6 in dyslipidaemic patients. alpha-Linolenic Acid 8-28 interleukin 6 Homo sapiens 79-92 16612254-8 2006 There was a stepwise reduction in production of TNF-alpha and IL-6 with increasing doses of diazoxide, hydralazine and furosemide by placentas and PBMCs from these women with normal pregnancies. Furosemide 119-129 interleukin 6 Homo sapiens 62-66 16612254-9 2006 CONCLUSION: Our data suggest that the antihypertensive drugs clonidine and hydralazine can stimulate production of the circulating anti-inflammatory cytokine IL-10, whereas furosemide and diazoxide inhibit the production of this cytokine and the proinflammatory cytokines TNF-alpha and IL-6 by placentas and PBMCs. Clonidine 61-70 interleukin 6 Homo sapiens 286-290 16612254-9 2006 CONCLUSION: Our data suggest that the antihypertensive drugs clonidine and hydralazine can stimulate production of the circulating anti-inflammatory cytokine IL-10, whereas furosemide and diazoxide inhibit the production of this cytokine and the proinflammatory cytokines TNF-alpha and IL-6 by placentas and PBMCs. Furosemide 173-183 interleukin 6 Homo sapiens 286-290 12818406-9 2003 RESULTS: Dietary supplementation with ALA decreased significantly CRP, SAA and IL-6 levels. alpha-Linolenic Acid 38-41 interleukin 6 Homo sapiens 79-83 12818406-13 2003 CONCLUSIONS: Dietary supplementation with ALA for 3 months decreases significantly CRP, SAA and IL-6 levels in dyslipidaemic patients. alpha-Linolenic Acid 42-45 interleukin 6 Homo sapiens 96-100 16536800-15 2006 Cells incubated in 0.1 mmol L(-1) CaCl2 showed increased secretion of IL-6 over time, consistent with NF-kappaB activation. Calcium Chloride 34-39 interleukin 6 Homo sapiens 70-74 12797394-7 2003 Ofloxacin-treated patients showed increased endotoxin neutralizing capacity (ENC) 30 min after clamping compared to controls (15.8+/-15 vs 262.8+/-709 p=0.005) and increased IL-6 levels preoperatively and 30 min after clamping. Ofloxacin 0-9 interleukin 6 Homo sapiens 174-178 16536800-16 2006 The addition of AM to cells incubated with 0.1 mmol L(-1) CaCl2 showed a rapid decrease in IL-6 secretion after only 6 h. However, 1 mmol L(-1) CaCl2 did not induce secretion of IL-6 and the addition of AM did not affect the result. Calcium Chloride 58-63 interleukin 6 Homo sapiens 91-95 16536800-16 2006 The addition of AM to cells incubated with 0.1 mmol L(-1) CaCl2 showed a rapid decrease in IL-6 secretion after only 6 h. However, 1 mmol L(-1) CaCl2 did not induce secretion of IL-6 and the addition of AM did not affect the result. Calcium Chloride 58-63 interleukin 6 Homo sapiens 178-182 16536800-18 2006 Cells differentiated with 0.1 mmol L(-1) CaCl2 are still capable of generating an inflammatory response, showing signs of late NF-kappaB activation and IL-6 secretion that can be inhibited by AM. Calcium Chloride 41-46 interleukin 6 Homo sapiens 152-156 16536800-19 2006 However, cells differentiated with 1 mmol L(-1) CaCl2 lose their ability to secrete IL-6 but not AM, which could be acting as an antimicrobial peptide. Calcium Chloride 48-53 interleukin 6 Homo sapiens 84-88 12797394-11 2003 Oral ofloxacin prophylaxis may influence the ENC and IL-6 plasma levels but had no effect on complications, endotoxin and other inflammatory mediators. Ofloxacin 5-14 interleukin 6 Homo sapiens 53-57 16547239-3 2006 2) The tetC(+) PC subset contained a fraction of cycling cells, expressed high levels of DR, CD138, and CD126, and responded to IL-6 by improving their survival and Ig secretion; in contrast, the tetC(-) PC showed higher CXCR4 and lower DR and CD138, did not respond to IL-6, and contained a fraction of apoptotic cells. tetc 7-11 interleukin 6 Homo sapiens 128-132 12841342-0 2003 The effect of early treatment by cerivastatin on the serum level of C-reactive protein, interleukin-6, and interleukin-8 in the patients with unstable angina and non-Q-wave myocardial infarction. cerivastatin 33-45 interleukin 6 Homo sapiens 88-101 16499718-6 2006 DX-9065a inhibited FXa-induced IL-6 mRNA expression and NF-kappaB activation. (2S)-2-(4-(((3S)-1-acetimidoyl-3-pyrrolidinyl)oxy)phenyl)-3-(7-amidino-2-naphtyl)propanoic acid 0-8 interleukin 6 Homo sapiens 31-35 16690518-6 2006 In the intermediate group risk defined by IPI, patients presenting high level of sIL-2R or IL-6 demonstrated lower CR rate and survival than those with low level. diprotin A 42-45 interleukin 6 Homo sapiens 91-95 16690518-7 2006 In conclusion, sIL-2R and IL-6 serum levels are elevated in high grade NHL and are correlated to CR, OS and FFS, but this study did not support their independent prognostic value. CHEMBL1198227 108-111 interleukin 6 Homo sapiens 26-30 16553947-0 2006 Beta-(1-->3)-D-glucan modulates DNA binding of nuclear factors kappaB, AT and IL-6 leading to an anti-inflammatory shift of the IL-1beta/IL-1 receptor antagonist ratio. beta-(1-->3)-d-glucan 0-24 interleukin 6 Homo sapiens 81-85 12841342-1 2003 The aim of our study was to evaluate whether a single dose of cerivastatin at the time of admission of patients with unstable angina pectoris (UAP) or non-Q-wave myocardial infarction (NQMI) can influence the serum level of C-reactive protein (CRP), interleukin-6 (IL-6) and interleukin-8 (IL-8) 24 h later. cerivastatin 62-74 interleukin 6 Homo sapiens 250-263 12841342-1 2003 The aim of our study was to evaluate whether a single dose of cerivastatin at the time of admission of patients with unstable angina pectoris (UAP) or non-Q-wave myocardial infarction (NQMI) can influence the serum level of C-reactive protein (CRP), interleukin-6 (IL-6) and interleukin-8 (IL-8) 24 h later. cerivastatin 62-74 interleukin 6 Homo sapiens 265-269 16527606-4 2006 IL-6 and IL-8 secretion was greater in coincubates of aCTL cells with 13-06-ISP and 13-06-CSP immunoselected cells than those with 13-06-MG parental cells. 13-06-isp 70-79 interleukin 6 Homo sapiens 0-4 12841342-9 2003 Our results suggest that early treatment with cerivastatin can decrease the serum level of CRP and IL-6 in patients with UAP/NQMI; this might positively influence their prognosis. cerivastatin 46-58 interleukin 6 Homo sapiens 99-103 12453911-13 2002 The AGE- and CML-dependent activation of NF-kappaBp65 and NF-kappaB-dependent IL-6 expression could be inhibited using the soluble form of the receptor for AGEs (RAGE) (soluble RAGE [sRAGE]), RAGE-specific antibody, or the antioxidant thioctic acid. Thioctic Acid 235-248 interleukin 6 Homo sapiens 78-82 16607071-4 2006 The odds ratio for myocardial infarction increased progressively across the four quarters of the homocysteine distribution, after adjusting for only age and sex or for the full adjustment (age, sex, smoking, systolic blood pressure, total cholesterol, fibrinogen, C-reactive protein and interleukin-6). Homocysteine 97-109 interleukin 6 Homo sapiens 287-300 17002794-13 2006 On day seven, IL-6 was directly correlated with ADMA levels (p = 0.006). N,N-dimethylarginine 48-52 interleukin 6 Homo sapiens 14-18 15931619-0 2005 Association of plasma homocysteine with serum interleukin-6 and C-peptide levels in patients with type 2 diabetes. Homocysteine 22-34 interleukin 6 Homo sapiens 46-59 15931619-6 2005 Elevated plasma Hcy levels correlated significantly with serum IL-6 ( r = 0.25, P < .001), C-peptide ( r = 0.22, P < .01), and the number of abnormal metabolic factors ( r = 0.20, P < .01), but not with C-reactive protein. Homocysteine 16-19 interleukin 6 Homo sapiens 63-67 15931619-7 2005 Multiple linear regression analysis revealed that log-transformed IL-6, serum C-peptide, vitamin B12 , and creatinine were significant determinants of plasma Hcy levels. Homocysteine 158-161 interleukin 6 Homo sapiens 66-70 15931619-9 2005 The association between plasma Hcy and serum IL-6 levels supports the hypothesis that the activation of innate immunity is involved in the pathogenesis of arteriosclerosis in patients with diabetes mellitus who are homozygous for the TT genotype of C677T MTHFR. Homocysteine 31-34 interleukin 6 Homo sapiens 45-49 15836625-13 2005 Moreover, a protein kinase C inhibitor, calphostin C, dramatically suppressed IL-6 release, whereas a protein kinase A inhibitor H-89 and a Ca2+ chelator EGTA failed. calphostin C 40-52 interleukin 6 Homo sapiens 78-82 16308450-4 2005 We have found, that pentazocine, SKF 10 047, dextrorphan reduce spontaneous secretion of IL-8, IL-6 and IL-10 and selectively changes synthesis of IL-4 by Jurkat human T lymphocyte cells lines. 1,2,3,4-tetrahydroisoquinoline-7-sulfonamide 33-36 interleukin 6 Homo sapiens 95-99 12429044-10 2002 In conclusion, dissociation of cortisol relative to DHEA, DHEAS or 17OH-progesterone appears very early during a systemic inflammatory response which is associated with an increase of IL-6 relative to TNF. 17-alpha-Hydroxyprogesterone 67-84 interleukin 6 Homo sapiens 184-188 16278782-6 2005 In human adipocytes, ritonavir at therapeutic concentrations inhibited insulin-stimulated lipogenesis, reduced GLUT4 mRNA, fatty acid synthase and adiponectin expression, while increasing IL-6 mRNA expression. Ritonavir 21-30 interleukin 6 Homo sapiens 188-192 15781640-2 2005 In order to clarify the effect of DHEA on myeloma cells, we investigated whether DHEA and DHEA-S could inhibit interleukin-6 (IL-6) production of bone marrow mononuclear cells and the proliferation of myeloma cells from patients with myeloma. Dehydroepiandrosterone 81-85 interleukin 6 Homo sapiens 111-124 15781640-2 2005 In order to clarify the effect of DHEA on myeloma cells, we investigated whether DHEA and DHEA-S could inhibit interleukin-6 (IL-6) production of bone marrow mononuclear cells and the proliferation of myeloma cells from patients with myeloma. Dehydroepiandrosterone 81-85 interleukin 6 Homo sapiens 126-130 12433058-2 2002 Inhibition of glutathione-oxidized disulfide reductase, which recycles GSSG --> 2GSH, by the action of 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) augmented LPS-dependent secretion of interleukin (IL)-1beta, IL-6 and tumor necrosis factor (TNF)-alpha. Carmustine 106-143 interleukin 6 Homo sapiens 212-216 15781640-3 2005 DHEA-S and DHEA suppressed IL-6 production from a bone marrow stromal cell line, KM-102, as well as in bone marrow mononuclear cells from patients with myeloma. Dehydroepiandrosterone 0-4 interleukin 6 Homo sapiens 27-31 15781640-6 2005 DHEA up-regulated the expression of peroxisome proliferator-activated receptor (PPAR), PPAR beta, but not PPARgamma or PPARalpha, and the expression of IkappaBalpha gene in myeloma cells and bone marrow stromal cells, which could explain the suppressive effect of DHEA on IL-6 production through the down-regulation of NF-kappaB activity. Dehydroepiandrosterone 0-4 interleukin 6 Homo sapiens 272-276 15781640-7 2005 Therefore, these data revealed that DHEA-S, as well as DHEA, had a direct effect on myeloma and bone marrow stromal cells to inhibit their proliferation and IL-6 production, respectively. Dehydroepiandrosterone 36-40 interleukin 6 Homo sapiens 157-161 15550066-5 2004 Effects of PD98059, SB202190 and SP600125 (inhibitors of ERK, p38 and JNK, respectively) on IL-1beta-induced secretion of IL-6 and IL-8, and on IL-1beta-induced expression of cyclo-oxygenase-2 (COX-2) in endometriotic cells were studied. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 20-28 interleukin 6 Homo sapiens 122-126 15550066-8 2004 Both SB202190 and SP600125 suppressed IL-1beta-induced secretion of IL-6 and IL-8, and PD98059 suppressed IL-1beta-induced secretion of IL-8. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 5-13 interleukin 6 Homo sapiens 68-72 15913932-8 2005 DFX also induced IL-6 production and HIF-1alpha expression in the inner ear. Deferoxamine 0-3 interleukin 6 Homo sapiens 17-21 15913932-9 2005 We demonstrated the regulatory effects of MAPK, HIF-1alpha, and NF-kappaB on DFX-induced IL-6 production in a HEI-OC1 for the first time. Deferoxamine 77-80 interleukin 6 Homo sapiens 89-93 15913932-10 2005 In conclusion, these data indicate that regulation of inflammatory cytokine IL-6 by DFX, through mimicking hypoxic conditions, might explain its beneficial effect in the treatment of hypoxia-induced inner ear diseases. Deferoxamine 84-87 interleukin 6 Homo sapiens 76-80 15914040-5 2005 TC productions of IL-6, IL-8, and IL-10 were measured by enzyme-linked immunosorbent assay (ELISA). Technetium 0-2 interleukin 6 Homo sapiens 18-22 16085044-6 2005 There was a stepwise reduction of TNF-alpha (23.6-97.5% reduction) and IL-6 (13.7-71% reduction) with increasing doses of betamethasone and methyl-prednisolone from placentas of women with preeclampsia and normal pregnancy. Methylprednisolone 140-159 interleukin 6 Homo sapiens 71-75 12165438-1 2002 We describe the development of a robust and sensitive assay system (detection limit <500 pg/ml biotin-IL-6, K(d)=75 ng/ml), using Luminex-100 microspheres, that could effectively screen for neutralizing antibody whenever a soluble form of the receptor for a target molecule is available. Biotin 98-104 interleukin 6 Homo sapiens 105-109 16087976-5 2005 RESULTS: After adjustment for multiple potential confounders, interleukin 1 receptor antagonist (IL-1ra) and interleukin 6 (IL-6) concentrations were significantly (P < 0.001) associated with plasma homocysteine concentrations in older (>65 y) populations. Homocysteine 202-214 interleukin 6 Homo sapiens 109-122 16087976-5 2005 RESULTS: After adjustment for multiple potential confounders, interleukin 1 receptor antagonist (IL-1ra) and interleukin 6 (IL-6) concentrations were significantly (P < 0.001) associated with plasma homocysteine concentrations in older (>65 y) populations. Homocysteine 202-214 interleukin 6 Homo sapiens 124-128 16087976-6 2005 Compared with participants in the lowest IL-6 tertile, those in the highest tertile had a higher risk of having homocysteine concentrations that were high (>30 micromol/L; odds ratio: 2.6; 95% CI: 1.1, 5.6; P = 0.024) or in the intermediate range 15-30 micromol/L (odds ratio: 1.6; 95% CI: 1.2, 2.2; P = 0.0014). Homocysteine 112-124 interleukin 6 Homo sapiens 41-45 16087976-8 2005 CONCLUSIONS: High circulating concentrations of IL-1ra and IL-6 are independent correlates of hyperhomocysteinemia and may explain, at least in part, the association between homocysteine and atherosclerosis. Homocysteine 99-111 interleukin 6 Homo sapiens 59-63 15567770-5 2004 In clozapine group, the levels of IL-2 after 4 weeks and IL-6 and IL-18 after 6 months were lowered significantly (P<0.01 or 0.05). Clozapine 3-12 interleukin 6 Homo sapiens 57-61 15567770-12 2004 CONCLUSION: Clozapine and risperidone have similar immunosuppression actions and may affect serum IL-6 levels in patients with paranoid schizophrenia, in the psychopathology of which the cytokines play their roles of various importance. Clozapine 12-21 interleukin 6 Homo sapiens 98-102 15519185-11 2004 Low-dose of methylprednisolone (5 mg/kg) effectively reduced the increase in TNF-alpha and IL-6 secretion (P<0.05 compared to control group) after release of the cross-clamp. Methylprednisolone 12-30 interleukin 6 Homo sapiens 91-95 12165438-2 2002 As an example, we coupled a recombinant human interleukin-6 soluble receptor to a Luminex carboxylated microsphere and used a biotin-labeled recombinant human interleukin-6 as a probe to assess binding competition. Biotin 126-132 interleukin 6 Homo sapiens 159-172 15316561-0 2004 Abrogation of IL-6-mediated JAK signalling by the cyclopentenone prostaglandin 15d-PGJ(2) in oral squamous carcinoma cells. cyclopentenone 50-64 interleukin 6 Homo sapiens 14-18 16096456-12 2005 Addition of DHEA to the culture medium, however, significantly improved the release of interleukin-1beta and tumor necrosis factor-alpha and stimulated the interleukin-6 release capacity of PBMC. Dehydroepiandrosterone 12-16 interleukin 6 Homo sapiens 156-169 12473263-4 2002 Paraformaldehyde (0.1% for 2min) or actinomycin-D (1 microg/ml for 24h) pre-treatment of the F-spheroids abolished the monocyte IL-6 co-culture response. Dactinomycin 36-49 interleukin 6 Homo sapiens 128-132 16014026-0 2005 Oxalate stimulates IL-6 production in HK-2 cells, a line of human renal proximal tubular epithelial cells. Oxalates 0-7 interleukin 6 Homo sapiens 19-23 16014026-5 2005 In the present study, we investigated the role of oxalate, a major constituent of calcium oxalate kidney stone disease, in the production of IL-6 in normal human HK-2 kidney cells. Oxalates 50-57 interleukin 6 Homo sapiens 141-145 15342284-7 2004 IL-6 was decreased 17% by enalapril and 20% by losartan. Losartan 47-55 interleukin 6 Homo sapiens 0-4 15342284-9 2004 In these high producers of IL-6, release of IL-6 was decreased 51% by enalapril (adjusted p = 0.001) and 32% by losartan (adjusted p = 0.068). Losartan 112-120 interleukin 6 Homo sapiens 27-31 15342284-9 2004 In these high producers of IL-6, release of IL-6 was decreased 51% by enalapril (adjusted p = 0.001) and 32% by losartan (adjusted p = 0.068). Losartan 112-120 interleukin 6 Homo sapiens 44-48 16014026-11 2005 Oxalate increased the secretion of IL-6 protein in HK-2 cells in a concentration-dependent fashion. Oxalates 0-7 interleukin 6 Homo sapiens 35-39 12353854-6 2002 IL-6 was higher in intestinal samples of the short-chain fatty acid group (P = 0.05), with the ileum having a greater abundance of IL-6 than the jejunum (P < 0.005). short 45-50 interleukin 6 Homo sapiens 0-4 16014026-12 2005 Oxalate exposure to HK-2 cells also induced transcriptional up-regulation of the IL-6 gene, as determined by the increased level of IL-6 mRNA expression following treatment with oxalate. Oxalates 0-7 interleukin 6 Homo sapiens 81-85 16014026-12 2005 Oxalate exposure to HK-2 cells also induced transcriptional up-regulation of the IL-6 gene, as determined by the increased level of IL-6 mRNA expression following treatment with oxalate. Oxalates 0-7 interleukin 6 Homo sapiens 132-136 16014026-12 2005 Oxalate exposure to HK-2 cells also induced transcriptional up-regulation of the IL-6 gene, as determined by the increased level of IL-6 mRNA expression following treatment with oxalate. Oxalates 178-185 interleukin 6 Homo sapiens 81-85 16014026-12 2005 Oxalate exposure to HK-2 cells also induced transcriptional up-regulation of the IL-6 gene, as determined by the increased level of IL-6 mRNA expression following treatment with oxalate. Oxalates 178-185 interleukin 6 Homo sapiens 132-136 16014026-13 2005 Moreover, the effects of oxalate on IL-6 expression were time- and concentration-dependent. Oxalates 25-32 interleukin 6 Homo sapiens 36-40 16014026-14 2005 This is the first report demonstrating the regulation of IL-6 by oxalate. Oxalates 65-72 interleukin 6 Homo sapiens 57-61 15591651-2 2004 Pentoxifylline (PTX) has the property of inhibiting TNF-alpha, IL-1, and IL-6 production. Pentoxifylline 0-14 interleukin 6 Homo sapiens 73-77 15591651-2 2004 Pentoxifylline (PTX) has the property of inhibiting TNF-alpha, IL-1, and IL-6 production. Pentoxifylline 16-19 interleukin 6 Homo sapiens 73-77 12080442-8 2002 Both catecholamines increased IL-6 and leptin secretion. Catecholamines 5-19 interleukin 6 Homo sapiens 30-34 15271731-6 2004 For patients in the clonidine group, production of IL-1RA, IL-6, and IL-8 was significantly less increased at the end of the surgical procedure and at 12 and 24 h after surgery. Clonidine 20-29 interleukin 6 Homo sapiens 59-63 16014026-15 2005 CONCLUSION: This study provides the first direct evidence that oxalate up-regulates the expression and secretion of IL-6 in renal epithelial cells. Oxalates 63-70 interleukin 6 Homo sapiens 116-120 12080442-9 2002 The effects of dexamethasone and catecholamines on IL-6 and leptin were abrogated by RU486 and propranolol, respectively. Catecholamines 33-47 interleukin 6 Homo sapiens 51-55 15840591-7 2005 Inhibition was not specific for IL-10, as induction of STAT activation by IFN-gamma and IL-6 was also inhibited by 15d-PGJ2. 15-deoxy-delta(12,14)-prostaglandin J2 115-123 interleukin 6 Homo sapiens 88-92 12111578-4 2002 Only ofloxacin showed a significant inhibitory influence on the endotoxin-induced IL-6 production of PBMNC. Ofloxacin 5-14 interleukin 6 Homo sapiens 82-86 15158790-3 2004 The levels at which these compounds inhibit the function of nuclear factor kappa B (NF-kappaB) and potentiate heat shock factor (HSF) are reported and the possible relevance of these studies concerning the antiviral and anti-inflammatory activities of the cyclopentenone prostanoids is discussed. cyclopentenone 256-270 interleukin 6 Homo sapiens 110-127 15158790-3 2004 The levels at which these compounds inhibit the function of nuclear factor kappa B (NF-kappaB) and potentiate heat shock factor (HSF) are reported and the possible relevance of these studies concerning the antiviral and anti-inflammatory activities of the cyclopentenone prostanoids is discussed. cyclopentenone 256-270 interleukin 6 Homo sapiens 129-132 12027072-0 2002 Azelastine is more potent than olopatadine n inhibiting interleukin-6 and tryptase release from human umbilical cord blood-derived cultured mast cells. olopatadine n 31-44 interleukin 6 Homo sapiens 56-69 15155869-7 2004 Serum IL-6 >/=17 pg/mL was associated with an abnormal CUS in infants >28 wk GA (OR 3.36, p = 0.023) but not </=28 wk GA. CSF concentrations of IL-6 >/=6.5 pg/mL and TNF-alpha >/=3 pg/mL were associated with abnormal CUS in infants </=28 wk GA (IL-6 OR 3.0; TNF-alpha OR 3.5; p < 0.05 each case) but not >/=28 wk GA. cus 58-61 interleukin 6 Homo sapiens 6-10 15155869-7 2004 Serum IL-6 >/=17 pg/mL was associated with an abnormal CUS in infants >28 wk GA (OR 3.36, p = 0.023) but not </=28 wk GA. CSF concentrations of IL-6 >/=6.5 pg/mL and TNF-alpha >/=3 pg/mL were associated with abnormal CUS in infants </=28 wk GA (IL-6 OR 3.0; TNF-alpha OR 3.5; p < 0.05 each case) but not >/=28 wk GA. cus 58-61 interleukin 6 Homo sapiens 153-157 15155869-7 2004 Serum IL-6 >/=17 pg/mL was associated with an abnormal CUS in infants >28 wk GA (OR 3.36, p = 0.023) but not </=28 wk GA. CSF concentrations of IL-6 >/=6.5 pg/mL and TNF-alpha >/=3 pg/mL were associated with abnormal CUS in infants </=28 wk GA (IL-6 OR 3.0; TNF-alpha OR 3.5; p < 0.05 each case) but not >/=28 wk GA. cus 58-61 interleukin 6 Homo sapiens 153-157 15155869-7 2004 Serum IL-6 >/=17 pg/mL was associated with an abnormal CUS in infants >28 wk GA (OR 3.36, p = 0.023) but not </=28 wk GA. CSF concentrations of IL-6 >/=6.5 pg/mL and TNF-alpha >/=3 pg/mL were associated with abnormal CUS in infants </=28 wk GA (IL-6 OR 3.0; TNF-alpha OR 3.5; p < 0.05 each case) but not >/=28 wk GA. cus 232-235 interleukin 6 Homo sapiens 6-10 12010778-7 2002 8-Bromo cyclic AMP and dibutyryl cyclic AMP, cyclic AMP analogues, mimicked the effects of PGE(2) on IL-6, M-CSF, and VEGF production by OA fibroblasts. Bucladesine 23-43 interleukin 6 Homo sapiens 101-105 11953371-8 2002 In contrast, IL-6 and IL-11 significantly suppressed butyric acid- or Fas-induced apoptosis in a dose-dependent fashion. Butyric Acid 53-65 interleukin 6 Homo sapiens 13-17 14996842-9 2004 The mRNA for ligands of the gp130-JAK/STAT3 signaling pathway, interleukin-6, leukemia inhibitory factor, and oncostatin M were elevated prior to activation of STAT3 and induction of astrogliosis; neuroprotection with nomifensine blocked these effects of MPTP. Nomifensine 218-229 interleukin 6 Homo sapiens 63-76 11953371-10 2002 These results suggest that the proinflammatory cytokines such as IL-6 and IL-11, produced in fibroblasts stimulated with butyric acid, are involved in the attenuation of T-cell apoptosis by gingival fibroblasts. Butyric Acid 121-133 interleukin 6 Homo sapiens 65-69 11981085-7 2002 There was an association between symptoms and increased levels of mycophenolic acid (MPA) acyl glucuronide and serum interleukin-6, suggesting the induction of inflammatory cytokines by MPA acyl glucuronide as the cause of the syndrome. Glucuronides 95-106 interleukin 6 Homo sapiens 117-130 11788581-1 2002 Interleukin 6 (IL-6) is endowed with a lectin activity for oligosaccharide ligands possessing the HNK-1 epitope (3-sulfated glucuronic acid) found on some mammalian glycoprotein N-glycans (Cebo, C., Dambrouck, T., Maes, E., Laden, C., Strecker, G., Michalski, J. C., and Zanetta, J. P. (2001) J. Biol. dambrouck 199-208 interleukin 6 Homo sapiens 0-13 11788581-1 2002 Interleukin 6 (IL-6) is endowed with a lectin activity for oligosaccharide ligands possessing the HNK-1 epitope (3-sulfated glucuronic acid) found on some mammalian glycoprotein N-glycans (Cebo, C., Dambrouck, T., Maes, E., Laden, C., Strecker, G., Michalski, J. C., and Zanetta, J. P. (2001) J. Biol. dambrouck 199-208 interleukin 6 Homo sapiens 15-19 11835156-8 2002 MEHQ (1.6-16 microM) reduced the IL-6 response by >50%. mequinol 0-4 interleukin 6 Homo sapiens 33-37 11950021-10 2002 ACECLO, DICLO, INDO, NIM significantly inhibited basal and IL-1beta stimulated IL-6 production; CELE and IBUP only inhibited IL-1beta stimulated IL-6 production; and ROFE and PIROX had no significant effects. Indomethacin 15-19 interleukin 6 Homo sapiens 79-83 11950021-10 2002 ACECLO, DICLO, INDO, NIM significantly inhibited basal and IL-1beta stimulated IL-6 production; CELE and IBUP only inhibited IL-1beta stimulated IL-6 production; and ROFE and PIROX had no significant effects. nimesulide 21-24 interleukin 6 Homo sapiens 79-83 11920401-4 2002 However, in RA and ReA patients compared with healthy subjects, levels of ACTH, cortisol, ASD, DHEAS, and 17-OH-progesterone were markedly lower in relation to levels of IL-6 and TNF. 17-alpha-Hydroxyprogesterone 106-124 interleukin 6 Homo sapiens 170-174 12090904-6 2002 The effects of fluvastatin on IL-6 expression were completely reversed in the presence of mevalonate or geranylgeranyl-pyrophosphate, but not squalene. Mevalonic Acid 90-100 interleukin 6 Homo sapiens 30-34 11882700-3 2002 This study shows that treatment of human intestinal epithelial T84 cells with Etx induces expression of IL-6, IL-10, IL-1R antagonist, as well as IL-1alpha and IL-1beta and low levels of IL-8. 2-ethoxyethanol 78-81 interleukin 6 Homo sapiens 104-108 12436208-1 2002 The effect of taurine (Tau) and taurine chloramine (Tau-Cl) on the production of TNF- alpha, IL-1 beta, and IL-6 by peripheral blood mononuclear cells of healthy volunteers was examined. tau-cl 52-58 interleukin 6 Homo sapiens 108-112 12436208-4 2002 In LPS-stimulated cells Tau-Cl inhibited both the secreted and cell-associated IL-1 beta and IL-6, while exerted dual effect on TNF- alpha production: raising it slightly at low and reducing at higher concentration. tau-cl 24-30 interleukin 6 Homo sapiens 93-97 12230916-7 2002 In human PAECs, IL-6 and TXA(2) release induced by LPS (0-1 microg/ml) or CCPA (0-1 microM) at high doses was significantly reduced by the selective A(1) adenosine receptor antagonist, 8-cyclopentyl-1,3-dipropylxanthine (DPCPX; 1 microM). 1,3-dipropyl-8-cyclopentylxanthine 185-219 interleukin 6 Homo sapiens 16-20 12230916-7 2002 In human PAECs, IL-6 and TXA(2) release induced by LPS (0-1 microg/ml) or CCPA (0-1 microM) at high doses was significantly reduced by the selective A(1) adenosine receptor antagonist, 8-cyclopentyl-1,3-dipropylxanthine (DPCPX; 1 microM). 1,3-dipropyl-8-cyclopentylxanthine 221-226 interleukin 6 Homo sapiens 16-20 11751424-11 2001 This study also determined the level of 8-hydroxydeoxyguanosine (8-OH-dGua), an indicator for oxidative DNA lesions in IL-6-treated or mcl-1-overexpressed AGS cells after treatment with H(2)O(2). 8-oh-dgua 65-74 interleukin 6 Homo sapiens 119-123 11751424-12 2001 Notably, our results indicate that a majority of the 8-OH-dGua is efficiently removed in the AGS cells without IL-6 treatment, whereas only approximately 50% of the 8-OH-dGua was repaired in the IL-6-treated AGS cells after 24 h. Similarly, approximately 60-70% of the 8-OH-dGua also failed to repair and was retained in the genomic DNA of the mcl-1 transfectants. 8-oh-dgua 165-174 interleukin 6 Homo sapiens 195-199 11751424-12 2001 Notably, our results indicate that a majority of the 8-OH-dGua is efficiently removed in the AGS cells without IL-6 treatment, whereas only approximately 50% of the 8-OH-dGua was repaired in the IL-6-treated AGS cells after 24 h. Similarly, approximately 60-70% of the 8-OH-dGua also failed to repair and was retained in the genomic DNA of the mcl-1 transfectants. 8-oh-dgua 165-174 interleukin 6 Homo sapiens 195-199 12536495-1 2001 OBJECTIVE: To explore the influence of low-molecular weight heparin (LMWH) on interleukin-6 (IL-6) in patients with proliferative glomerulonephritis, 24 patients which had been distinctly diagnosed by renal biopsy were randomly divided into a control group (n = 12) and a treatment group (n = 12). Heparin, Low-Molecular-Weight 69-73 interleukin 6 Homo sapiens 78-91 12536495-1 2001 OBJECTIVE: To explore the influence of low-molecular weight heparin (LMWH) on interleukin-6 (IL-6) in patients with proliferative glomerulonephritis, 24 patients which had been distinctly diagnosed by renal biopsy were randomly divided into a control group (n = 12) and a treatment group (n = 12). Heparin, Low-Molecular-Weight 69-73 interleukin 6 Homo sapiens 93-97 11597988-4 2001 We first confirmed that antioxidant N-acetylcysteine, superoxide scavenger Tiron, and DPI suppressed Ang II-induced IL-6 expression. diphenyleneiodonium 86-89 interleukin 6 Homo sapiens 116-120 11518271-14 2001 Hydroxyapatite particles yielded a 30-fold increase in interleukin-6 secretion compared to unstimulated controls, which was also greater than three times the levels produced by cobalt chromium, titanium, or HA/TCP. Durapatite 0-14 interleukin 6 Homo sapiens 55-68 15111165-8 2004 The IL-6 and IL-8 levels were significantly lower in group P and group H than in group N. CONCLUSIONS: The PMEA coating was superior to heparin coating and noncoating in preserving platelets, and was equivalent to heparin coating in terms of the perioperative clinical course and inhibition of inflammatory cytokines, but slightly inferior in reducing complement activation. poly(2-methoxyethylacrylate) 107-111 interleukin 6 Homo sapiens 4-8 14984727-2 2004 Pentoxifylline, a xanthin-derived agent, is known to inhibit the production of TNF-alpha and IL-6. Pentoxifylline 0-14 interleukin 6 Homo sapiens 93-97 14711936-4 2004 Here, we report that celecoxib, one of the new class of selective COX-2 inhibitors, has the potential to reverse tumor-mediated wasting and associated humoral factors such as interleukin (IL)-6 and hypercalcemia in preclinical models of cachexia. Celecoxib 21-30 interleukin 6 Homo sapiens 175-193 15062036-7 2004 The levels of IL-6, ICAM-1 and P-selectin in serum were not found any difference between LTx group and PLC group, while the levels of IL-6, ICAM-1 and P-selectin in serum shown significant difference between LTx and healthy groups (P = 0.048, 0.000 and 0.025, respectively). Leukotriene C4 208-211 interleukin 6 Homo sapiens 134-138 15071991-2 2004 For the patients with CTBD quite high metabolic activity of neutrophils according to data of spontaneous test with nitroblue tetrazolium (NBT-test), reduction of IgA content in the initial period, significant raising of interleukin-6 (IL-6) level on the first postoperative day are characteristic. ctbd 22-26 interleukin 6 Homo sapiens 220-233 15071991-2 2004 For the patients with CTBD quite high metabolic activity of neutrophils according to data of spontaneous test with nitroblue tetrazolium (NBT-test), reduction of IgA content in the initial period, significant raising of interleukin-6 (IL-6) level on the first postoperative day are characteristic. ctbd 22-26 interleukin 6 Homo sapiens 235-239 14671038-0 2004 Effects of mycophenolic acid on IL-6 expression of human renal proximal and distal tubular cells in vitro. Mycophenolic Acid 11-28 interleukin 6 Homo sapiens 32-36 14671038-4 2004 Until now no data about the effect of the immunosuppressant drug mycophenolic acid (MPA) on IL-6 expression were available. Mycophenolic Acid 65-82 interleukin 6 Homo sapiens 92-96 14671038-4 2004 Until now no data about the effect of the immunosuppressant drug mycophenolic acid (MPA) on IL-6 expression were available. Mycophenolic Acid 84-87 interleukin 6 Homo sapiens 92-96 16190383-5 2005 Celecoxib reduced IL-6 and MMP-9 secretion level of monocytes from ACS patients up to 48% and 50% respectively (all P < 0.05), in a concentration-dependent manner. Celecoxib 0-9 interleukin 6 Homo sapiens 18-22 16396302-6 2005 Complex treatment with zonal ultraviolet irradiation and methylprednisolone aceponatatis proved to be effective and normalized indices of Interleukin-6 and its receptor in blood serum of patients with psoriasis. Methylprednisolone 57-75 interleukin 6 Homo sapiens 138-151 15942148-9 2005 Increased levels of IL-6 were associated with decreased levels of TC (r = -0.266, p = 0.019), LDL-C (r = -0.376, p = 0.001) and apolipoprotein AI (apo AI) (r = -0.495, p < 0.001) in all IDC patients. Technetium 66-68 interleukin 6 Homo sapiens 20-24 15876336-7 2005 RESULTS: IL-6 levels were increased in the acute phase of stroke compared with healthy controls (P = 0.002) and correlated with larger stroke volume (P = 0.012) and less favorable prognosis after 1 year, measured by ESS (P = 0.014) and BI (P = 0.006). ESS 216-219 interleukin 6 Homo sapiens 9-13 16130059-0 2005 Effects of ketamine on serum and tracheobronchial aspirate interleukin-6 levels in infants undergoing cardiac surgery. Ketamine 11-19 interleukin 6 Homo sapiens 59-72 16130059-3 2005 In the present study, the authors aimed to compare the effects of ketamine anesthesia and isoflurane anesthesia with respect to serum and tracheobronchial aspirate (TBA) IL-6 levels in infants undergoing CPB for cardiac surgery. Ketamine 66-74 interleukin 6 Homo sapiens 170-174 15925303-3 2005 EPA, DHA, and AA have negative feedback control on tumor necrosis factor-alpha and IL-6 synthesis. Docosahexaenoic Acids 5-8 interleukin 6 Homo sapiens 83-87 15925303-4 2005 Hence, EPA, DHA, and AA deficiencies induced by an energy-dense diet increase generation of tumor necrosis factor-alpha and interleukin-6, markers of inflammation that in turn decrease production of endothelial nitric oxide and adiponectin to induce insulin resistance in maternal and fetal tissues. Docosahexaenoic Acids 12-15 interleukin 6 Homo sapiens 124-137 15963050-5 2005 Treatment of bone marrow-derived DCs with GD(3) before lipopolysaccharide-induced maturation decreased the production of interleukin-6 (IL-6), IL-10, IL-12 and tumor necrosis factor-alpha as well as reduced the alloreactivity in mixed leucocyte reaction (MLR). Gadolinium 42-44 interleukin 6 Homo sapiens 121-134 15963050-5 2005 Treatment of bone marrow-derived DCs with GD(3) before lipopolysaccharide-induced maturation decreased the production of interleukin-6 (IL-6), IL-10, IL-12 and tumor necrosis factor-alpha as well as reduced the alloreactivity in mixed leucocyte reaction (MLR). Gadolinium 42-44 interleukin 6 Homo sapiens 136-140 15777635-0 2005 Interleukin-6 and osteoprotegerin systems in Paget"s disease of bone: relationship to risedronate treatment. Risedronic Acid 86-97 interleukin 6 Homo sapiens 0-13 15655130-7 2005 Treatment with irbesartan and/or lipoic acid was associated with statistically significant reductions in plasma levels of interleukin-6 and plasminogen activator-1. Irbesartan 15-25 interleukin 6 Homo sapiens 122-135 15367426-6 2005 Importantly, stimulation of cells from patients with MM, either with IL-6 or by adherence to BMSCs, enhanced the anti-proliferative and proapoptotic effects of patupilone. epothilone B 160-170 interleukin 6 Homo sapiens 69-73 15502050-3 2004 We investigated the hypothesis that preincisional IV pentoxifylline (PTX) treatment could attenuate the release of proinflammatory (tumor necrosis factor, interleukin (IL)-1beta, IL-6, and IL-8) and antiinflammatory (IL-1 receptor antagonist) cytokines in patients who underwent elective colorectal cancer surgery. Pentoxifylline 53-67 interleukin 6 Homo sapiens 179-183 15502050-3 2004 We investigated the hypothesis that preincisional IV pentoxifylline (PTX) treatment could attenuate the release of proinflammatory (tumor necrosis factor, interleukin (IL)-1beta, IL-6, and IL-8) and antiinflammatory (IL-1 receptor antagonist) cytokines in patients who underwent elective colorectal cancer surgery. Pentoxifylline 69-72 interleukin 6 Homo sapiens 179-183 15634571-2 2004 METHODS: The hHSF gene was obtained by overlapping PCR and cloned into the vector pET30a to yield pET30a-hHSF, which was transformed into E. coli BL21(DE3) and expressed with IPTG induction. Isopropyl Thiogalactoside 175-179 interleukin 6 Homo sapiens 13-17 15634571-2 2004 METHODS: The hHSF gene was obtained by overlapping PCR and cloned into the vector pET30a to yield pET30a-hHSF, which was transformed into E. coli BL21(DE3) and expressed with IPTG induction. Isopropyl Thiogalactoside 175-179 interleukin 6 Homo sapiens 105-109 14997289-6 2004 The frequencies of the different IL-6 genotypes were 27.5% (GG), 47.9% (GC), 24.6% (CC). gallocatechol 72-74 interleukin 6 Homo sapiens 33-37 15727386-0 2004 Effect of pentoxifylline on tumor necrosis factor-alpha and interleukin-6 levels in neonatal sepsis. Pentoxifylline 10-24 interleukin 6 Homo sapiens 60-73 15188490-3 2004 HHcy unleashes mediators of inflammation such as NFkappaB, IL-1beta, IL-6, and IL-8, increases production of intracellular superoxide anion causing oxidative stress and reducing intracellular level of nitric oxide (NO), and induces endoplasmic reticulum (ER) stress which can explain many processes of Hcy-promoted cell injury such as apoptosis, fat accumulation, and inflammation. Homocysteine 1-4 interleukin 6 Homo sapiens 69-73 15173725-9 2004 CONCLUSIONS: The polysulfon filter showed a filtration profile for inflammatory mediators superior to that of the polyamid filter for interleukin 6, tumor necrosis factor, and interleukin 10. polysulfon 17-27 interleukin 6 Homo sapiens 134-170 15298427-12 2004 CONCLUSION: In this study, we have found that preoperative administration of methylprednisolone has decreased TNF-alpha, IL-6 and IL-8 release, and increased the perfusing IL-10 levels after CPB. Methylprednisolone 77-95 interleukin 6 Homo sapiens 121-125 14754879-7 2004 Conversely, TGF-beta1 inhibition of cytokine-mediated induction of iNOS and IL-6 expression was completely blocked in Smad3-deficient VSMCs. vsmcs 134-139 interleukin 6 Homo sapiens 76-80 15180356-7 2004 Fexofenadine significantly inhibited IL6 (p < 0.004) and TNFalpha (p < 0.004) levels in comparison with placebo. fexofenadine 0-12 interleukin 6 Homo sapiens 37-40 15180356-9 2004 Fexofenadine reduces TNFalpha and IL6 levels only. fexofenadine 0-12 interleukin 6 Homo sapiens 34-37 14704253-0 2004 Inhibition of amniotic interleukin-6 and prostaglandin E2 release by ampicillin. Ampicillin 69-79 interleukin 6 Homo sapiens 23-36 14704253-1 2004 OBJECTIVE: To test the effect of ampicillin on amniotic interleukin-6 (IL-6) and prostaglandin E2 (PGE2) release. Ampicillin 33-43 interleukin 6 Homo sapiens 56-69 14704253-1 2004 OBJECTIVE: To test the effect of ampicillin on amniotic interleukin-6 (IL-6) and prostaglandin E2 (PGE2) release. Ampicillin 33-43 interleukin 6 Homo sapiens 71-75 14704253-5 2004 RESULTS: At doses ranging from 10-7 to 10-4 M, ampicillin decreased IL-6 release from Wistar Institute Susan Hayflick cells. Ampicillin 47-57 interleukin 6 Homo sapiens 68-72 14704253-8 2004 Finally, IL-6 levels measured in amniotic fluid of patients sampled 4 hours after ampicillin administration proved strongly and significantly reduced when compared with those sampled either before or 12 hours after treatment (P <.001). Ampicillin 82-92 interleukin 6 Homo sapiens 9-13 14704253-9 2004 CONCLUSION: The capacity of ampicillin to directly decrease amniotic IL-6 and PGE2 release should be considered in the management of bacterial and nonbacterial inflammatory complications of pregnancy mediated by the cytokine and prostanoid interaction. Ampicillin 28-38 interleukin 6 Homo sapiens 69-73 14503991-6 2003 RESULTS: Interleukin-6 production by human saphenous vein endothelial cells was significantly stimulated following a 24-h treatment with homocysteine, whilst IL-8 concentrations were inhibited after both 4- and 24-h treatments. Homocysteine 137-149 interleukin 6 Homo sapiens 9-22 12889010-10 2003 Titanium dioxide-coated silicone inhibited IL-6 production by 77% compared to uncoated silicone. Silicones 24-32 interleukin 6 Homo sapiens 43-47 14616867-7 2003 RESULTS: Ebastine inhibited T cell proliferation and the production of IL-4, IL-5, IL-6, and TNF-alpha by T cells under each co-stimulatory condition tested, whereas it exhibited no effect on the production of IL-2 or IFN-gamma. ebastine 9-17 interleukin 6 Homo sapiens 83-87 14616867-8 2003 In addition, T cell migration and the production of such pro-inflammatory cytokines as TNF-alpha and IL-6 by macrophages were inhibited by ebastine. ebastine 139-147 interleukin 6 Homo sapiens 101-105 11312479-14 2001 Increases in interleukin-6, leukocyte count, and oxygen uptake index, all of which developed after CPB, were significantly less in the milrinone group than in the control group. Milrinone 135-144 interleukin 6 Homo sapiens 13-26 14586407-3 2003 We further demonstrate that IL-6 protects an esophageal carcinoma cell line CE48T/VGH from apoptosis induced by staurosporine. ce48t 76-81 interleukin 6 Homo sapiens 28-32 12821113-6 2003 In addition, DFX significantly increased the production of IL-6, IL-8, and TNF-alpha in HMC-1 (P<0.05). Deferoxamine 13-16 interleukin 6 Homo sapiens 59-63 12853969-6 2003 IL-6 activation by TGF-beta1 was accompanied by nuclear translocation of NF-kappaB, which was blocked by the p38 inhibitors SB202190 and SB203580 or by IkappaBalphaDeltaN transfection, indicating the crucial role for the p38-NF-kappaB signaling in TGF-beta1 induction of IL-6. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 124-132 interleukin 6 Homo sapiens 0-4 12915102-8 2003 It was found that the increase in IL-6 protein and mRNA by the PA coal was completely eliminated by the pretreatment of both cell types with PD98059, a specific MEK1 inhibitor, and SB202190, a p38 kinase inhibitor. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 181-189 interleukin 6 Homo sapiens 34-38 11298095-5 2001 Cultured tumour cells showed IL-6 protein synthesis, and nonsteroidal anti-inflammatory drugs such as naproxen and indomethacin directly inhibited IL-6 release. Naproxen 102-110 interleukin 6 Homo sapiens 147-151 12794024-7 2003 RESULTS: After reperfusion, systemic levels of TNF-alpha were significantly less increased in the PTX group (peak, 2.8 vs. 1.3 ng/mL; P <.05), as were interleukin-6 values (peak, 68 vs. 22 pg/mL; P <.02) and lipopolysaccharide-binding protein plasma levels (peak, 215 vs. 105 micro g/mL; P <.03). Pentoxifylline 98-101 interleukin 6 Homo sapiens 154-167 12829649-3 2003 Statistically significant hazard ratios of developing diabetes for those in the fourth (versus first) quartile of inflammation markers, adjusted for age, sex, ethnicity, study center, parental history of diabetes, and hypertension, ranged from 1.9 to 2.8 for sialic acid, orosomucoid, interleukin-6, and C-reactive protein. N-Acetylneuraminic Acid 259-270 interleukin 6 Homo sapiens 285-298 11298095-5 2001 Cultured tumour cells showed IL-6 protein synthesis, and nonsteroidal anti-inflammatory drugs such as naproxen and indomethacin directly inhibited IL-6 release. Indomethacin 115-127 interleukin 6 Homo sapiens 147-151 12892382-14 2003 CONCLUSION: These results may suggest that the severity of AMI is reflected by the blood IL-6 and MMP-1 levels and that pretreatment with Mg administration protects the myocardium of patients with AMI from reperfusion injury induced by IL-6 and MMP-1. Magnesium 138-140 interleukin 6 Homo sapiens 89-93 12562454-4 2003 Dehydroepiandrosterone inhibits nuclear factor-kappaB and the secretion of interleukin-6 and interleukin-12 via the peroxisome proliferator-activated receptor alpha. Dehydroepiandrosterone 0-22 interleukin 6 Homo sapiens 75-88 12892382-14 2003 CONCLUSION: These results may suggest that the severity of AMI is reflected by the blood IL-6 and MMP-1 levels and that pretreatment with Mg administration protects the myocardium of patients with AMI from reperfusion injury induced by IL-6 and MMP-1. Magnesium 138-140 interleukin 6 Homo sapiens 236-240 11298095-6 2001 These results indicate that the effects of naproxen in vivo were due, at least in part, to direct suppression of IL-6 secretion from the tumour. Naproxen 43-51 interleukin 6 Homo sapiens 113-117 11344824-9 2001 Acetaldehyde markedly increased TNF-alpha and IL-8 expression, stimulated IL-1 beta and IL-8 secretion, increased lipid peroxidation damage and decreased catalase activity, while LPS exposure induced the expression of TNF-alpha, TGF-beta 1, IL-6 and IL-8, the secretion of TGF-beta 1, IL-1 beta, IL-6 and IL-8, and a decrease in catalase activity. Acetaldehyde 0-12 interleukin 6 Homo sapiens 241-245 12944727-9 2003 PMX-F treatment reduced plasma endotoxin (p < 0.01) and IL-6 levels (p < 0.01) and increased the ratio of branched-chain amino acids to aromatic amino acids (p < 0.01). pmx-f 0-5 interleukin 6 Homo sapiens 59-63 12736519-3 2003 DFX significantly increased interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-alpha production compared with the control in a time-dependent manner (p<0.05), but did not affect IL-1alpha production and mRNA expression. Deferoxamine 0-3 interleukin 6 Homo sapiens 28-46 12720588-12 2003 The threshold of EPA+DHA intake that results in decreased IL-6 production is between 0.44 and 0.94 g/d. Docosahexaenoic Acids 21-24 interleukin 6 Homo sapiens 58-62 12509619-8 2003 The inhibition of MMP-1 and IL-6 production was due to the known inhibitory effect of A77 1726 on pyrimidine synthesis, as it was reversed by the addition of uridine. Uridine 158-165 interleukin 6 Homo sapiens 28-32 11344824-9 2001 Acetaldehyde markedly increased TNF-alpha and IL-8 expression, stimulated IL-1 beta and IL-8 secretion, increased lipid peroxidation damage and decreased catalase activity, while LPS exposure induced the expression of TNF-alpha, TGF-beta 1, IL-6 and IL-8, the secretion of TGF-beta 1, IL-1 beta, IL-6 and IL-8, and a decrease in catalase activity. Acetaldehyde 0-12 interleukin 6 Homo sapiens 296-300 11104703-6 2000 In related experiments, the protein tyrosine phosphatase inhibitor Na(3)VO(4) also antagonized the inhibitory effect of IL-1beta on the activation of STAT1 by IL-6. na(3)vo(4) 67-77 interleukin 6 Homo sapiens 159-163 12635880-1 2002 Our objective was to evaluate the effect of intravenous magnesium sulphate administration to patients with preterm labour on maternal serum and amniotic fluid IL-1beta, IL-6, IL-10 and TNFalpha concentrations. Magnesium Sulfate 56-74 interleukin 6 Homo sapiens 169-173 12429044-9 2002 The ratio of serum IL-6/TNF was positively correlated with the ratio of serum cortisol/DHEA (R(Rank)=0.472, P=0.041) and serum cortisol/17OH-progesterone (R(Rank)=0.514, P=0.048). Dehydroepiandrosterone 87-91 interleukin 6 Homo sapiens 19-23 12433059-4 2002 As expected, LPS induced the secretion of substantial amounts of all measured parameters, whereas only minor amounts of TNFalpha, IL-6, and IL-10 were induced by beta-glucan itself. beta-Glucans 162-173 interleukin 6 Homo sapiens 130-134 12433059-7 2002 On the other hand, soluble beta-glucan strongly primed LPS stimulation of all parameters, including TNFalpha and IL-6. beta-Glucans 27-38 interleukin 6 Homo sapiens 113-117 12576419-0 2003 Flavopiridol-related proinflammatory syndrome is associated with induction of interleukin-6. alvocidib 0-12 interleukin 6 Homo sapiens 78-91 12576419-10 2003 Moreover, IL-6 elevation had a direct correlation with flavopiridol peak plasma concentration, flavopiridol area under the curve, and plasma C-Reactive protein levels. alvocidib 55-67 interleukin 6 Homo sapiens 10-14 12576419-10 2003 Moreover, IL-6 elevation had a direct correlation with flavopiridol peak plasma concentration, flavopiridol area under the curve, and plasma C-Reactive protein levels. alvocidib 95-107 interleukin 6 Homo sapiens 10-14 12576419-14 2003 CONCLUSION: Biochemical analysis of plasma in patients undergoing infusional flavopiridol found a significant dose-dependent induction of IL-6. alvocidib 77-89 interleukin 6 Homo sapiens 138-142 12576419-15 2003 IL-6 elevation could be a marker for the process leading to the appearance of the proinflammatory syndrome observed in patients treated with infusional flavopiridol. alvocidib 152-164 interleukin 6 Homo sapiens 0-4 11007619-13 2000 The pharmacologic agents (ciprofloxacin, pentoxifylline, and indomethacin) that can modulate the release of bone resorbing mediators such as PGE(2), TNF-alpha, IL-1, and IL-6 release from human monocytes. Indomethacin 61-73 interleukin 6 Homo sapiens 170-174 12576419-16 2003 The mechanism(s) underlying IL-6 induction and its significance are still unknown but may influence strategies to modulate flavopiridol"s clinical effects. alvocidib 123-135 interleukin 6 Homo sapiens 28-32 10971321-4 2000 RESULTS: DBcAMP stimulated keratinocyte proliferation through increased interleukin (IL)-6 production by fibroblasts, and transiently enhanced production of transforming growth factor (TGF)-beta1 by fibroblasts at an early stage of incubation. Bucladesine 9-15 interleukin 6 Homo sapiens 72-90 12478000-6 2002 There was a correlation between the patients with high risk according to the IPI criteria and high levels of serum cytokines (IL-2, IL-6, IL-10). diprotin A 77-80 interleukin 6 Homo sapiens 132-136 12070216-4 2002 This increase in PKC is observed with 15 min of HDE treatment, and kinase activity reaches peak activity by 1-2 h of HDE treatment before returning to baseline PKC levels between 6 and 24 h. The classic PKC inhibitor, calphostin C, blocks HDE-stimulated PKC activity and associated IL-8 and IL-6 release. calphostin C 218-230 interleukin 6 Homo sapiens 291-295 12052568-9 2002 In conclusion, the levels of the well known proinflammatory cytokines TNF-alpha, IL-1beta and IL-6 increased in the V. vulnificus septicemic patients" sera, and the levels of TNF-alpha and IL-1beta decreased significantly after doxycycline treatment. Doxycycline 228-239 interleukin 6 Homo sapiens 94-98 10971321-5 2000 DBcAMP also stimulated fibroblast proliferation, resulting in further increases in IL-6 and TGF-beta1. Bucladesine 0-6 interleukin 6 Homo sapiens 83-87 12067409-6 2002 Treatment of the cells with actinomycin D inhibited IL-6 expression in response to MG-132, suggesting the transcriptional upregulation of IL-6 under proteasomal inhibition. Magnesium 83-85 interleukin 6 Homo sapiens 52-56 12431386-5 2002 IL-6 activates transcription mediated by nuclear factor of activated T cells (NFAT) leading to production of IL-4 by nai;ve CD4(+) T cells and their differentiation into effector Th2 cells. Sodium Iodide 117-120 interleukin 6 Homo sapiens 0-4 12067409-6 2002 Treatment of the cells with actinomycin D inhibited IL-6 expression in response to MG-132, suggesting the transcriptional upregulation of IL-6 under proteasomal inhibition. Magnesium 83-85 interleukin 6 Homo sapiens 138-142 10922312-2 2000 Several inflammatory cytokines involved in malnutrition, including interleukin-1, interleukin-6, and tumor necrosis factor-alpha, are modulated by 1,25-dihydroxyvitamin D(3) [1,25-(OH)(2)D(3)], of which synthesis is impaired in end-stage renal disease. 1,25-dihydroxyvitamin D 147-170 interleukin 6 Homo sapiens 82-95 12220910-4 2002 During the study period, we found significant higher levels of acute phase proteins, IL-6 and -8 in patients >30% TBSA. tbsa 117-121 interleukin 6 Homo sapiens 85-96 10922477-1 2000 Prior activation of mitogen-activated protein kinases by phorbol 13-myristate 12-acetate (PMA) results in an inhibition of interleukin (IL)-6-induced activation of the Janus kinase/signal transducer and activator of transcription (STAT) signaling pathway which is most likely mediated by the induction of suppressor of cytokine signaling-3 and requires the specific SHP2 binding site Y759 of the IL-6 signal transducer gp130. phorbol 13-myristate 12-acetate 57-88 interleukin 6 Homo sapiens 123-141 12073659-2 2002 Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulphate (DHEA)--the major androgen products of the adrenal gland--have immunosuppressive effect inhibiting interleukin-6 production and substantially determining acute phase reaction. Dehydroepiandrosterone 0-22 interleukin 6 Homo sapiens 165-178 12073659-2 2002 Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulphate (DHEA)--the major androgen products of the adrenal gland--have immunosuppressive effect inhibiting interleukin-6 production and substantially determining acute phase reaction. Dehydroepiandrosterone 24-28 interleukin 6 Homo sapiens 165-178 12073659-2 2002 Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulphate (DHEA)--the major androgen products of the adrenal gland--have immunosuppressive effect inhibiting interleukin-6 production and substantially determining acute phase reaction. Dehydroepiandrosterone 67-71 interleukin 6 Homo sapiens 165-178 12208756-7 2002 PTK787 enhances the inhibitory effect of dexamethasone on growth of MM cells and can overcome the protective effect of interleukin 6 (IL-6) against dexamethasone-induced apoptosis. vatalanib 0-6 interleukin 6 Homo sapiens 119-132 10922477-1 2000 Prior activation of mitogen-activated protein kinases by phorbol 13-myristate 12-acetate (PMA) results in an inhibition of interleukin (IL)-6-induced activation of the Janus kinase/signal transducer and activator of transcription (STAT) signaling pathway which is most likely mediated by the induction of suppressor of cytokine signaling-3 and requires the specific SHP2 binding site Y759 of the IL-6 signal transducer gp130. phorbol 13-myristate 12-acetate 57-88 interleukin 6 Homo sapiens 396-400 12208756-7 2002 PTK787 enhances the inhibitory effect of dexamethasone on growth of MM cells and can overcome the protective effect of interleukin 6 (IL-6) against dexamethasone-induced apoptosis. vatalanib 0-6 interleukin 6 Homo sapiens 134-138 12208756-10 2002 These findings therefore demonstrate that PTK787 both acts directly on MM cells and inhibits paracrine IL-6-mediated MM cell growth in the bone marrow milieu. vatalanib 42-48 interleukin 6 Homo sapiens 103-107 12143044-7 2002 Thus, PGs alone can induce cholangiocarcinoma growth, and the HGF- and IL-6-induced proliferation is mediated, at least in part, by PGs. Phosphatidylglycerols 132-135 interleukin 6 Homo sapiens 71-75 11916764-0 2002 A randomized trial of supplementation with docosahexaenoic acid-rich tuna oil and its effects on the human milk cytokines interleukin 1 beta, interleukin 6, and tumor necrosis factor alpha. Docosahexaenoic Acids 43-63 interleukin 6 Homo sapiens 142-155 11108572-5 2000 Among OA patients in whom remarkable improvement was noted in hydrarthrosis, the synovial fluid IL-6 and IL-8 levels at the initial examination were relatively higher, and were markedly decreased after treatment with sodium hyaluronate (NaHA). naha 237-241 interleukin 6 Homo sapiens 96-100 11888843-4 2002 Furthermore, we tested the predictive role of serum tumour necrosis factor (TNF) and interleukin-6 (IL-6) for a change of serum levels of DHEA in relation to other adrenal hormones. Dehydroepiandrosterone 138-142 interleukin 6 Homo sapiens 85-98 11108572-6 2000 Among those in whom no improvement was noted in hydrarthrosis, the synovial fluid IL-6 and IL-8 levels at the time of initial examination were relatively lower, and hydrarthrosis was not significantly improved even after treatment with NaHA. naha 236-240 interleukin 6 Homo sapiens 82-86 11888843-4 2002 Furthermore, we tested the predictive role of serum tumour necrosis factor (TNF) and interleukin-6 (IL-6) for a change of serum levels of DHEA in relation to other adrenal hormones. Dehydroepiandrosterone 138-142 interleukin 6 Homo sapiens 100-104 11888843-7 2002 A multiple linear regression analysis revealed that elevated serum levels of TNF were associated with a high ratio of serum levels of DHEA/ASD in all groups (for IL-6 in patients with an acute inflammatory stressful disease state only), and, similarly, elevated serum levels of TNF were associated with a high ratio of serum levels of DHEAS/DHEA only in IBD (for IL-6 only in healthy subjects). Dehydroepiandrosterone 134-138 interleukin 6 Homo sapiens 162-166 12175093-1 2002 Ketamine may be advantageous for anesthesia of patients with sepsis caused by gram-negative bacteria, because ketamine may suppress LPS-induced production of proinflammatory cytokines, such as TNFalpha and IL-6. Ketamine 0-8 interleukin 6 Homo sapiens 206-210 12175093-1 2002 Ketamine may be advantageous for anesthesia of patients with sepsis caused by gram-negative bacteria, because ketamine may suppress LPS-induced production of proinflammatory cytokines, such as TNFalpha and IL-6. Ketamine 110-118 interleukin 6 Homo sapiens 206-210 11108572-9 2000 In low-grade cases, as determined by X-ray findings, there was a significant decrease in IL-6 levels in synovial fluid after treatment with NaHA. naha 140-144 interleukin 6 Homo sapiens 89-93 11842936-6 2002 11-deoxy-PGE1, a selective EP2/EP3/EP4 agonist, and butaprost, a selective EP2 agonist, inhibited IL-1beta-induced IL-6 production, although butaprost was less potent than 11-deoxy-PGE1. butaprost 52-61 interleukin 6 Homo sapiens 115-119 10834930-0 2000 Catecholamines up-regulate lipopolysaccharide-induced IL-6 production in human microvascular endothelial cells. Catecholamines 0-14 interleukin 6 Homo sapiens 54-58 11799073-6 2002 One of signaling pathways by which GSA activates VSMCs appears to be via nuclear factor kappaB activation, leading to induction of MCP-1 and IL-6 gene expression, comparable to the effects of lipopolysaccharide, TNF-alphaa, and IL-1alphab. vsmcs 49-54 interleukin 6 Homo sapiens 141-145 11799073-9 2002 Incubation of VSMCs with the antioxidant N-acetylcysteine suppressed GSA-elicited mRNA induction of MCP-1 and IL-6. vsmcs 14-19 interleukin 6 Homo sapiens 110-114 12100143-0 2002 Manumycin inhibits farnesyltransferase and induces apoptosis of drug-resistant interleukin 6-producing myeloma cells. manumycin 0-9 interleukin 6 Homo sapiens 79-92 12100143-3 2002 Based on our previous demonstration that IL-6-producing myeloma cells are refractory to drug-induced apoptosis, we have analysed the effect of manumycin, a natural FTase inhibitor, on IL-6-producing myeloma cells resistant to Fas-, dexamethasone- and doxorubicin-induced apoptosis. manumycin 143-152 interleukin 6 Homo sapiens 184-188 10834930-2 2000 Whereas catecholamines decrease the LPS-induced production of IL-6 by leukocytes, serum levels of IL-6 are dramatically increased by the catecholamine epinephrine in animal endotoxemia models. Catecholamines 8-22 interleukin 6 Homo sapiens 62-66 11872748-7 2002 Moreover, PS-1145 blocks the protective effect of IL-6 against Dex-induced apotosis. PS1145 10-17 interleukin 6 Homo sapiens 50-54 10834930-4 2000 Furthermore, these catecholamines could even potentiate the LPS-induced IL-6 protein production. Catecholamines 19-33 interleukin 6 Homo sapiens 72-76 11872748-9 2002 Moreover, PS-1145 inhibits both IL-6 secretion from BMSCs triggered by MM cell adhesion and proliferation of MM cells adherent to BMSCs. PS1145 10-17 interleukin 6 Homo sapiens 32-36 12375150-4 2002 Pentoxifylline (PTX) is also known to inhibit such inflammatory mediators as tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6. Pentoxifylline 0-14 interleukin 6 Homo sapiens 129-142 10834930-6 2000 The catecholamine-induced IL-6 stimulation is based on increased IL-6 mRNA levels. Catecholamines 4-17 interleukin 6 Homo sapiens 26-30 12375150-4 2002 Pentoxifylline (PTX) is also known to inhibit such inflammatory mediators as tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6. Pentoxifylline 16-19 interleukin 6 Homo sapiens 129-142 10834930-6 2000 The catecholamine-induced IL-6 stimulation is based on increased IL-6 mRNA levels. Catecholamines 4-17 interleukin 6 Homo sapiens 65-69 11766169-4 2001 In the absence of LPS, DON at 500 or 1,000 ng/ml upregulated TNF-alpha production as early as 3 h and up to 6 h, whereas 100 to 1,000 ng/ml of DON significantly increased production of IL-6 from 3 to 24 h and IL-8 from 6 to 48 h. In cells costimulated with 0.2 microg/ml LPS, DON at 500 or 1000 ng/ml markedly superinduced TNF-alpha and IL-8 production. DONS 143-146 interleukin 6 Homo sapiens 185-189 11766169-5 2001 Although 100 ng/ml of DON also potentiated LPS-induced IL-6 production, 500 or 1,000 ng/ ml of the toxin suppressed the LPS-induced IL-6 response. DONS 22-25 interleukin 6 Homo sapiens 55-59 10834930-10 2000 Thus, endothelial cells might be a possible source of increased IL-6 production observed in situations such as stress or septic shock, in which catecholamines are elevated due to endogenous production or exogenous application. Catecholamines 144-158 interleukin 6 Homo sapiens 64-68 12102472-0 2002 Clodronate treatment reduces serum levels of interleukin-6 soluble receptor in Paget"s disease of bone. Clodronic Acid 0-10 interleukin 6 Homo sapiens 45-58 12102472-5 2002 The aim of this study was to evaluate the modification in the serum levels of IL-6, sIL-6R and osteotropic hormones (parathormone, 25OHD3 and 1,25(OH)2D3) as a in long-term response to clodronate treatment in patients with PDB. Clodronic Acid 185-195 interleukin 6 Homo sapiens 78-82 10935448-5 2000 In contrast, beta-catenin protein levels were reduced markedly in NTera2-N cells by exposure to dbcAMP, EGF or bFGF, and in U-373MG cells by treatment with dbcAMP or PMA, but were unaffected in any cell lines by BDNF, TNF-alpha, IL-1beta, IL-6, IFN-gamma or TGF-beta1. Bucladesine 156-162 interleukin 6 Homo sapiens 239-243 12102472-11 2002 Eight weeks after treatment, the maximal pharmacological response to clodronate was associated with a significant reduction of sIL-6R serum levels in all patients, without a significant variation in serum IL-6 and osteotropic hormone levels. Clodronic Acid 69-79 interleukin 6 Homo sapiens 128-132 11970975-6 2002 In contrast, both prostanoids and IL-6 were found to contribute to the TDSN-induced inhibition of DC differentiation from CD34(+) precursor cells. tdsn 71-75 interleukin 6 Homo sapiens 34-38 11934726-6 2002 Patients treated with methylprednisolone had progressive and sustained reductions of TNF-alpha, IL-1beta, IL-6, ACTH, and cortisol concentrations over time. Methylprednisolone 22-40 interleukin 6 Homo sapiens 106-110 11739520-4 2001 IL-1beta and TNF-alpha, and to a lesser degree IL-6, accelerate facilitated glucose transport as measured by [(3)H]2-deoxyglucose uptake. Deoxyglucose 115-129 interleukin 6 Homo sapiens 47-51 11814313-2 2001 We tested the hypothesis that IL-6 secretion by human marrow cells and a line of marrow stromal cells (KM101) is inhibited by dehydroepiandrosterone (DHEA), dihydrotestosterone (DHT) and 17beta-oestradiol (E(2)). Dehydroepiandrosterone 126-148 interleukin 6 Homo sapiens 30-34 11814313-2 2001 We tested the hypothesis that IL-6 secretion by human marrow cells and a line of marrow stromal cells (KM101) is inhibited by dehydroepiandrosterone (DHEA), dihydrotestosterone (DHT) and 17beta-oestradiol (E(2)). Dehydroepiandrosterone 150-154 interleukin 6 Homo sapiens 30-34 11814313-6 2001 DHEA suppressed IL-6 more consistently than DHT or E(2): DHEA significantly suppressed IL-6 in 84% of cultures, DHT suppressed IL-6 in 58%, and E(2)did so in 50%. Dehydroepiandrosterone 0-4 interleukin 6 Homo sapiens 16-20 11814313-6 2001 DHEA suppressed IL-6 more consistently than DHT or E(2): DHEA significantly suppressed IL-6 in 84% of cultures, DHT suppressed IL-6 in 58%, and E(2)did so in 50%. Dehydroepiandrosterone 0-4 interleukin 6 Homo sapiens 87-91 11814313-6 2001 DHEA suppressed IL-6 more consistently than DHT or E(2): DHEA significantly suppressed IL-6 in 84% of cultures, DHT suppressed IL-6 in 58%, and E(2)did so in 50%. Dehydroepiandrosterone 0-4 interleukin 6 Homo sapiens 87-91 11687457-6 2001 Our clinical studies have shown that methylprednisolone is capable of reducing the levels of TNF-alpha, IL-1 beta, and IL-6 in ARDS patients. Methylprednisolone 37-55 interleukin 6 Homo sapiens 119-123 10802521-3 2000 The aims of this study were to determine the time course of immediate changes in biochemical markers of bone turnover after PTX and whether circulating IL-6 is involved in the immediate changes of bone turnover after PTX. ptx 217-220 interleukin 6 Homo sapiens 152-156 11687457-13 2001 We have also shown that steady-state mRNA levels of TNF-alpha, IL-1 beta, and IL-6 in LPS-activated cells were reduced by treatment of such cells with methylprednisolone, in a concentration-dependent manner. Methylprednisolone 151-169 interleukin 6 Homo sapiens 78-82 11749774-12 2001 After administration of methylprednisolone or aprotinin, leukocyte CD11b expression, plasma IL-6, IL-8, C-reactive protein levels, and MPO activity decreased by different extent. Methylprednisolone 24-42 interleukin 6 Homo sapiens 92-96 11986591-11 2002 The interleukin 8 level was significantly lower, and the interleukin 6 level had a tendency to be lower in the DHCA group compared with levels in the LF group. dhca 111-115 interleukin 6 Homo sapiens 57-70 10772282-1 2000 The in vitro effect of indomethacin (IM) on the production of interleukin (IL)-1beta, IL-6 and tumor necrosis factor (TNF)alpha by cord blood mononuclear cells (CBMC) from preterm newborns was compared to that of peripheral blood MC of adults (PBMC). Indomethacin 37-39 interleukin 6 Homo sapiens 86-90 11922699-4 2002 IgG secretion was, however, correlated with the secretions of IL-5 and IL-6 in MG. Magnesium 79-81 interleukin 6 Homo sapiens 71-75 11805217-9 2002 Simultaneous inhibition of PDE5, 6, and 9 (zaprinast), purported to specifically elevate intracellular cGMP, reduced, in a dose-independent manner, IL-6 and TNF-alpha biosynthesis. zaprinast 43-52 interleukin 6 Homo sapiens 148-152 11805217-10 2002 Finally, nonselective inhibition of PDE by pentoxifylline suppressed LPS-mediated secretion of IL-6 and TNF-alpha. Pentoxifylline 43-57 interleukin 6 Homo sapiens 95-99 11603453-10 2001 CONCLUSIONS: Preoperative administration of methylprednisolone blunted the increase of IL-6, TNF-alpha, and E-selectin levels after CPB but had no measurable effect on postoperative recovery. Methylprednisolone 44-62 interleukin 6 Homo sapiens 87-91 11583728-3 2001 Interleukin-6 (IL-6) suppresses the activity of lipoprotein lipase, which modulates the metabolism of triglycerides and HDL-C. To determine whether a reduction of IL-6 contributes to the improvement of lipid profiles, we prospectively investigated the effect of cilostazol (n=16, 100 mg, twice daily) on the changes of lipid profiles and on the association with the changes of IL-6 compared with those of pentoxifylline (n=16, 400 mg, bid) in patients with IC. Pentoxifylline 405-419 interleukin 6 Homo sapiens 0-13 11583728-3 2001 Interleukin-6 (IL-6) suppresses the activity of lipoprotein lipase, which modulates the metabolism of triglycerides and HDL-C. To determine whether a reduction of IL-6 contributes to the improvement of lipid profiles, we prospectively investigated the effect of cilostazol (n=16, 100 mg, twice daily) on the changes of lipid profiles and on the association with the changes of IL-6 compared with those of pentoxifylline (n=16, 400 mg, bid) in patients with IC. Pentoxifylline 405-419 interleukin 6 Homo sapiens 15-19 11727828-3 2001 Pretreatment of cells with the p38MAPK-specific inhibitor SB202190 downregulates the induction of SOCS3-mRNA expression by IL-6. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 58-66 interleukin 6 Homo sapiens 123-127 11766169-0 2001 Differential upregulation of TNF-alpha, IL-6, and IL-8 production by deoxynivalenol (vomitoxin) and other 8-ketotrichothecenes in a human macrophage model. deoxynivalenol 85-94 interleukin 6 Homo sapiens 40-44 11766169-4 2001 In the absence of LPS, DON at 500 or 1,000 ng/ml upregulated TNF-alpha production as early as 3 h and up to 6 h, whereas 100 to 1,000 ng/ml of DON significantly increased production of IL-6 from 3 to 24 h and IL-8 from 6 to 48 h. In cells costimulated with 0.2 microg/ml LPS, DON at 500 or 1000 ng/ml markedly superinduced TNF-alpha and IL-8 production. DONS 23-26 interleukin 6 Homo sapiens 185-189 10823386-3 2000 MAIN RESULTS: Catecholamines (epinephrine, norepinephrine, isoproterenol, and dopamine) in general inhibit tumor necrosis factor-alpha (TNF) production and may enhance interleukin-6 (IL-6) and IL-10 production. Catecholamines 14-28 interleukin 6 Homo sapiens 168-181 11766169-4 2001 In the absence of LPS, DON at 500 or 1,000 ng/ml upregulated TNF-alpha production as early as 3 h and up to 6 h, whereas 100 to 1,000 ng/ml of DON significantly increased production of IL-6 from 3 to 24 h and IL-8 from 6 to 48 h. In cells costimulated with 0.2 microg/ml LPS, DON at 500 or 1000 ng/ml markedly superinduced TNF-alpha and IL-8 production. DONS 143-146 interleukin 6 Homo sapiens 185-189 11814313-6 2001 DHEA suppressed IL-6 more consistently than DHT or E(2): DHEA significantly suppressed IL-6 in 84% of cultures, DHT suppressed IL-6 in 58%, and E(2)did so in 50%. Dehydroepiandrosterone 57-61 interleukin 6 Homo sapiens 87-91 11814313-6 2001 DHEA suppressed IL-6 more consistently than DHT or E(2): DHEA significantly suppressed IL-6 in 84% of cultures, DHT suppressed IL-6 in 58%, and E(2)did so in 50%. Dehydroepiandrosterone 57-61 interleukin 6 Homo sapiens 87-91 11814313-7 2001 The magnitude of IL-6 inhibition was also greater for DHEA (group mean, treated/control of 62%) compared to DHT (81%) and E(2)(76%). Dehydroepiandrosterone 54-58 interleukin 6 Homo sapiens 17-21 11814313-8 2001 In cultures from subjects receiving ERT, DHEA and DHT suppressed IL-6 in some, whereas E(2)did not suppress IL-6 secretion. Dehydroepiandrosterone 41-45 interleukin 6 Homo sapiens 65-69 11814313-10 2001 In summary, in marrow cultured from postmenopausal women, DHEA suppressed IL-6 secretion more consistently and to a greater degree than did DHT and E(2). Dehydroepiandrosterone 58-62 interleukin 6 Homo sapiens 74-78 11687457-4 2001 In addition, we have shown that the intracellular milieu of phagocytic cells that are exposed to supraoptimal concentrations of TNF-alpha, IL-1 beta, and IL-6 or lipopolysaccharide (LPS) favors survival and replication of ingested bacteria. supraoptimal 97-109 interleukin 6 Homo sapiens 154-158 11546726-1 2001 PURPOSE: To investigate the efficacy of S(+)-ketamine and R(-)-ketamine on staphylococcal enterotoxin B (SEB)-induced tumour necrosis factor (TNF)-, interleukin (IL)-6, and IL-8 production in human whole blood in vitro. Ketamine 40-53 interleukin 6 Homo sapiens 118-167 11546726-6 2001 Ketamine isomers at concentrations exceeding 100 microM also significantly suppressed SEB-induced IL-6 production. Ketamine 0-8 interleukin 6 Homo sapiens 98-102 11546726-9 2001 CONCLUSION: This study demonstrated that ketamine isomers suppressed SEB-induced TNF-, IL-6, and IL-8 production in human whole blood. Ketamine 41-49 interleukin 6 Homo sapiens 87-91 11509812-5 2001 Our results showed that dexamethasone, budesonide and rIL-10 significantly inhibited both IL-6 and TNF-alpha production in the THP-1 cell line stimulated by lipopolysaccharide and Ureaplasma urealyticum antigen. Budesonide 39-49 interleukin 6 Homo sapiens 90-94 10823386-3 2000 MAIN RESULTS: Catecholamines (epinephrine, norepinephrine, isoproterenol, and dopamine) in general inhibit tumor necrosis factor-alpha (TNF) production and may enhance interleukin-6 (IL-6) and IL-10 production. Catecholamines 14-28 interleukin 6 Homo sapiens 183-187 11268388-5 2000 The catecholamines and serotonin also synergistically stimulate IL-6 release in the presence of IL-1 beta. Catecholamines 4-18 interleukin 6 Homo sapiens 64-68 11408847-0 2001 The effects of intrapartum magnesium sulfate therapy on fetal serum interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha at delivery: a randomized, placebo-controlled trial. Magnesium Sulfate 27-44 interleukin 6 Homo sapiens 87-133 11408847-3 2001 The purpose of this study was to determine whether intrapartum magnesium sulfate therapy has an effect on the umbilical venous concentrations of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha at delivery. Magnesium Sulfate 63-80 interleukin 6 Homo sapiens 164-210 11699068-7 2001 PGE2, TNF-alpha and IL-6 levels were elevated perioperatively in T. versus C. Neopterin, a metabolite of activated monocytes and macrophages, was significantly activated on days -1 (C: 7.6 +/- 1.2 versus T: 20.5 +/- 2.4 nmol/mL; P < 0.001), day 1 (C: 8.3 +/- 1.4 nmol/mL versus T: 24.9 +/- 2.8 nmol/mL; P < 0.001), and day 4 (C: 9.5 +/- 1.1 nmol/mL versus T: 16.0 +/- 1.8 nmol/mL; P < 0.05). Neopterin 78-87 interleukin 6 Homo sapiens 20-24 11520766-10 2001 During the second 10-20 day phase, the level of both IL-6 and IL-8 decreased significantly in the presence of pentoxifylline, the relation between these two cytokines being the inverse of that observed in the absence of the drug. Pentoxifylline 110-124 interleukin 6 Homo sapiens 53-57 11520766-12 2001 CONCLUSION: The addition of pentoxifylline to organ culture media leads, ultimately, to a suppression of IL-6 and IL-8 secretion by corneal tissue. Pentoxifylline 28-42 interleukin 6 Homo sapiens 105-109 11453524-6 2001 Serum levels of IL-6, sIL-6R and IL-8 were markedly elevated in patients with GD before treatment with methimazole (p<0.0001 for IL-6, p<0.006 for sIL-6R, p<0.004 for IL-8) and after 8 weeks of therapy (p<0.011 for IL-6, p<0.04 for IL-8). Methimazole 103-114 interleukin 6 Homo sapiens 16-20 10620064-0 1999 Zoledronate is a potent inhibitor of myeloma cell growth and secretion of IL-6 and MMP-1 by the tumoral environment. Zoledronic Acid 0-11 interleukin 6 Homo sapiens 74-78 11453524-9 2001 Serum levels of tri-iodothyronine in patients with GD positively correlated with serum concentrations of IL-6 (r = 0.35, p<0.025) and sIL-6R (r = 0.31, p<0.047), while no correlation was found between thyroxine and cytokines. Triiodothyronine 16-33 interleukin 6 Homo sapiens 105-109 11311010-4 2001 In this study we have investigated the capacity of a range of different DBM preparations, and ECl dilutions, to induce the production of three pro-inflammatory cytokines, interleukin-6 (IL-6), interleukin-1beta (IL-1beta), and tumour necrosis factor alpha (TNF-alpha) from human peripheral blood mononuclear cells (PBMNCs). dbm 72-75 interleukin 6 Homo sapiens 171-184 11434990-8 2001 Short-term treatment of PHA-stimulated lymphocytes with DON (100, 200 and 400 ng/ml) modulated the kinetics of IL-2, IL-4 and IL-6 production. deoxynivalenol 56-59 interleukin 6 Homo sapiens 126-130 10620064-10 1999 In conclusion, the apoptosis of myeloma cells and BMSCs and the inhibition of both IL-6 and MMP-1 production induced by bisphosphonates, mainly zoledronate, could have antitumoral effects in patients with MM. Zoledronic Acid 144-155 interleukin 6 Homo sapiens 83-87 11434990-10 2001 IL-4 levels were only slightly elevated and IL-6 levels were slightly inhibited by these DON concentrations. deoxynivalenol 89-92 interleukin 6 Homo sapiens 44-48 11434990-13 2001 Consistent with earlier experiments, IL-6 levels were slightly suppressed by DON at this concentration. deoxynivalenol 77-80 interleukin 6 Homo sapiens 37-41 11356073-5 2001 In a mouse model of acute liver failure induced by d-galactosamine administration, a single low dose of a hyper-IL-6-encoding adenoviral vector, in contrast to an adeno-IL-6 vector, maintained liver function, prevented the progression of liver necrosis, and induced liver regeneration, leading to dramatically enhanced survival. Galactosamine 51-66 interleukin 6 Homo sapiens 112-116 10361345-5 1999 Indomethacin diminished secretion of PGE2, IL-1beta and IL-6 by AAA explants (see Table below). Indomethacin 1-13 interleukin 6 Homo sapiens 57-61 11167994-0 2001 Preliminary studies on the effect of dehydroepiandrosterone (DHEA) on both constitutive and phytohaemagglutinin (PHA)-inducible IL-6 and IL-2 mRNA expression and cytokine production in human spleen mononuclear cell suspensions in vitro. Dehydroepiandrosterone 37-59 interleukin 6 Homo sapiens 128-132 11327259-6 2001 In addition, treatment with 10 microg/ml doxycycline resulted in 2.2-fold upregulation of transforming growth factor (TGF-beta3) and a significant decrease of interleukin 1alpha (IL-1alpha), IL-1beta, and IL-6 mRNA. Doxycycline 41-52 interleukin 6 Homo sapiens 205-209 11289656-10 2001 Hymenialdisine inhibited IL-6 production and reduced IL-8 production dependent on synovial cell strains. hymenialdisine 0-14 interleukin 6 Homo sapiens 25-29 11167994-0 2001 Preliminary studies on the effect of dehydroepiandrosterone (DHEA) on both constitutive and phytohaemagglutinin (PHA)-inducible IL-6 and IL-2 mRNA expression and cytokine production in human spleen mononuclear cell suspensions in vitro. Dehydroepiandrosterone 61-65 interleukin 6 Homo sapiens 128-132 10361345-8 1999 Indomethacin reduces PGE2, IL-1beta and IL-6 synthesis in aneurysm tissue and NSAIDs appear to reduce AAA growth. Indomethacin 1-13 interleukin 6 Homo sapiens 41-45 11167994-1 2001 In order to gain further insight into the potential immunological benefits of oral administration of DHEA we have examined its effects on the constitutive and PHA-inducible expression by human spleen cell suspensions in vitro of IL-6 and IL-2. Dehydroepiandrosterone 101-105 interleukin 6 Homo sapiens 229-233 11042186-7 2001 Treatment of cells with deoxyspergualin, which exhibits high affinity to Hsps, the putative inhibitors of HSF, strongly increased only OS-induced hsp68 expression. gusperimus 24-39 interleukin 6 Homo sapiens 106-109 10385244-0 1999 Interleukin-6 production by activated human monocytic cells is enhanced by MK-571, a specific inhibitor of the multi-drug resistance protein-1. verlukast 75-81 interleukin 6 Homo sapiens 0-13 11007619-10 2000 Pentoxifylline potentiated IL-6 and IL-1 production in monocytes exposed to titanium particles and had a biphasic effect on the PGE(2) production. Pentoxifylline 0-14 interleukin 6 Homo sapiens 27-31 11080198-5 2000 Simultaneous addition of NPY at 10(-9) M: and the alpha-2-adrenergic agonist p-aminoclonidine further inhibited IL-6 secretion (p < 0.05). apraclonidine 77-93 interleukin 6 Homo sapiens 112-116 11084220-4 2000 The results show that noradrenaline, 10(-5) M, significantly suppressed the production of IL-6; noradrenaline, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA and TNF alpha; clonidine, 10(-5) M, significantly suppressed the production of TNF alpha; and yohimbine, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA. Clonidine 197-206 interleukin 6 Homo sapiens 90-94 11076827-7 2000 5-HT induced IL-6 production by VSMCs in a time- and dose-dependent manner, with increased IL-6 mRNA accumulation and nuclear factor-kappaB activation. vsmcs 32-37 interleukin 6 Homo sapiens 13-17 11046056-3 2000 We analyzed the effects of the inflammatory and stress agents, IL-1, TNF-alpha, LPS, sorbitol, and H(2)O(2), on signaling by IL-6 and IL-10, pleiotropic cytokines that activate the Jak-Stat signaling pathway and have both pro- and anti-inflammatory actions. Sorbitol 85-93 interleukin 6 Homo sapiens 125-129 10364906-5 1999 RESULTS: After hydroxychloroquine treatment, salivary IL6 concentrations decreased from 13.2 (1.2) to 7.3 (1.1) pg/ml (mean (SEM)) (p < 0.0001). Hydroxychloroquine 15-33 interleukin 6 Homo sapiens 54-57 10920220-3 2000 This study showed that exposure of MG-63 osteoblast-like cells to titanium particles at a concentration of 0.30% v/v resulted in a 15-fold increase in IL-6 release into the culture medium after 24 hours, when compared with cells without particles. Magnesium 35-37 interleukin 6 Homo sapiens 151-155 10920220-4 2000 Northern blots revealed that exposure of MG-63 cells to titanium particles at a concentration of 0.30% v/v for 24 hours increased IL-6 mRNA signal levels by 9.6-fold, when compared with control cultures. Magnesium 41-43 interleukin 6 Homo sapiens 130-134 10920220-5 2000 Pretreatment of MG-63 cells with cytochalasin B prevented the particle-induced increase of IL-6 expression but did not alter the basal level of IL-6 release from cells cultured in the absence of particles. Magnesium 16-18 interleukin 6 Homo sapiens 91-95 11037876-0 2000 The mechanism of taurine chloramine inhibition of cytokine (interleukin-6, interleukin-8) production by rheumatoid arthritis fibroblast-like synoviocytes. chloramine 25-35 interleukin 6 Homo sapiens 60-73 10220287-1 1999 We previously reported that SK2 hybridoma cells that secreted anti-human interleukin-6 (hIL-6) monoclonal antibodies (SK2 mAb) were microencapsulated within alginate-poly(L)lysine-alginate (APA) membranes (APA-SK2 cells) for immunoisolation, and a single intraperitoneal injection of these APA-SK2 cells remarkably improved IgG1 plasmacytosis in hIL-6 transgenic mice (hIL-6 Tgm). Alginates 157-165 interleukin 6 Homo sapiens 88-93 11027495-0 2000 Inhibition of interleukin-6 signaling and Stat3 activation by a new class of bioactive cyclopentenone derivatives. cyclopentenone 87-101 interleukin 6 Homo sapiens 14-27 10915744-5 2000 Four- and 10-fold activation of stress protein was detected by a consensus heat shock factor (HSF) sequence binding probe, with AFB and BP treatments, respectively. Benzo(a)pyrene 136-138 interleukin 6 Homo sapiens 75-92 10915744-5 2000 Four- and 10-fold activation of stress protein was detected by a consensus heat shock factor (HSF) sequence binding probe, with AFB and BP treatments, respectively. Benzo(a)pyrene 136-138 interleukin 6 Homo sapiens 94-97 10066641-8 1999 We observed an increased IL-1beta-, IL-6-, IL-8- and TNF-alpha-specific mRNA expression of particle or fibre exposed AM, which was decreased after an additional NO2 exposure. Nitrogen Dioxide 161-164 interleukin 6 Homo sapiens 36-47 10899931-11 2000 OSM-induced IL-6 mRNA and protein expression is inhibited by the mitogen-activated protein kinase (MAPK) inhibitors U0126 and SB202190, suggesting a requirement for the MAPKs ERK1/2 and p38 in this response. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 126-134 interleukin 6 Homo sapiens 12-16 10873580-6 2000 Interleukin-6-inducing activities of the active glycolipids from 1,25-dihydroxy vitamin D(3)-differentiated human monocytic leukemia cells, THP-1, were inhibited by anti-CD14 mAbs in a dose-dependent manner. Glycolipids 48-59 interleukin 6 Homo sapiens 0-13 10996844-4 2000 Removal of doxycycline from the culture medium elevated gp130 expression and increased the responsiveness of a STAT-responsive promoter-luciferase construct to IL-6 complexed with its soluble receptor (IL-6+sIL-6R), but diminished the responsiveness to oncostatin M (OSM). Doxycycline 11-22 interleukin 6 Homo sapiens 160-164 10996844-4 2000 Removal of doxycycline from the culture medium elevated gp130 expression and increased the responsiveness of a STAT-responsive promoter-luciferase construct to IL-6 complexed with its soluble receptor (IL-6+sIL-6R), but diminished the responsiveness to oncostatin M (OSM). Doxycycline 11-22 interleukin 6 Homo sapiens 202-206 10971177-14 2000 PS was improved in those cases in which the degree of IL-6 increase was suppressed by MPA, and many such cases showed low IL-6 levels prior to MPA therapy. ps 0-2 interleukin 6 Homo sapiens 54-58 9915315-7 1999 Venous and hepatic venous endotoxin and the interleukin 6 concentration were reduced significantly in the milrinone group. Milrinone 106-115 interleukin 6 Homo sapiens 44-57 10971177-14 2000 PS was improved in those cases in which the degree of IL-6 increase was suppressed by MPA, and many such cases showed low IL-6 levels prior to MPA therapy. ps 0-2 interleukin 6 Homo sapiens 122-126 10742653-7 2000 Clozapine 10(-4)M significantly suppressed the unstimulated production of IL-6 and IL-1RA and the stimulated production of IL-6, IL-10, IFNgamma and IL-1RA. Clozapine 0-9 interleukin 6 Homo sapiens 74-78 10825337-6 2000 In the comparison study between the control group and the clonidine group, there was a significant decrease in IL-6 level 3 h after the start of surgery and IL-1beta at preinduction time in the clonidine group, whereas there were no changes in tumor necrosis factor-alpha, cortisol, and ACTH levels. Clonidine 194-203 interleukin 6 Homo sapiens 111-115 10825337-7 2000 These results show that clonidine modulates the IL-6 response related to surgical stress. Clonidine 24-33 interleukin 6 Homo sapiens 48-52 10825337-9 2000 Clonidine 0.15 mg given as oral premedication resulted in the reduced Interleukin-6 production in response to total abdominal hysterectomy. Clonidine 0-9 interleukin 6 Homo sapiens 70-83 10880753-11 2000 GD1a-induced increases of IL-6 and IL-10 production in monocytes were both blocked by Ca(2)+/calmodulin (CaM)-dependent phosphodiesterase (PDE) inhibitors, 8-methoxymethyl-3-isobutyl-1-methylxanthine and vinpocetin, but not by other signal-transducing enzyme inhibitors. vinpocetine 204-214 interleukin 6 Homo sapiens 26-30 10863963-8 2000 Adenosine-induced IL-6 production was suppressed by protein kinase A (PKA) inhibitor, H89, indicating that cAMP/PKA pathway is involved in the induction. N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide 86-89 interleukin 6 Homo sapiens 18-22 10742653-7 2000 Clozapine 10(-4)M significantly suppressed the unstimulated production of IL-6 and IL-1RA and the stimulated production of IL-6, IL-10, IFNgamma and IL-1RA. Clozapine 0-9 interleukin 6 Homo sapiens 123-127 9920026-2 1999 METHODS: HSF were incubated with NIM (0.3, 3, and 30 microg/ml), NAP (15, 30, and 90 microg/ml), and dexamethasone (DEX; 0.01, 0.1, and 1 microM) on a time- and dose-dependent basis. Naproxen 65-68 interleukin 6 Homo sapiens 9-12 10865191-3 2000 Arabinosylated lipoarabinomannan (ARA-LAM) stimulated hyporesponsiveness by reducing TNF-alpha, GM-CSF, G-CSF, IL-10, and IL-6 release similarly to LPS, but caused no changes in IL-8 secretion. ara-lam 34-41 interleukin 6 Homo sapiens 122-126 10734320-6 2000 A pyrimidazole compound, SB203580, a specific inhibitor of p38 MAPK, inhibits production and gene expression of IL-6. pyrimidazole 2-14 interleukin 6 Homo sapiens 112-116 10719304-13 2000 GQ1b-induced increases in IL-6 and IL-10 production of T cells were both blocked by PKC inhibitors, calphostin C and staurosporine. calphostin C 100-112 interleukin 6 Homo sapiens 26-30 9843988-4 1998 IL-6 does not induce conventional maturation of dendritic cells but alters the pH of peripheral, early endosomal compartments and renders the cells more susceptible to killing by chloroquine. Chloroquine 179-190 interleukin 6 Homo sapiens 0-4 10619350-9 1999 RESULTS: There was a significant reduction in levels of TNF-alpha and IL-6 at a furosemide concentration of 0.5 x 10(-2) M and a reduction in IL-8 levels at 10(-2) M. This inhibition was comparable to that found with equivalent molar concentrations of hydrocortisone. Furosemide 80-90 interleukin 6 Homo sapiens 70-74 10632522-13 1999 However, CsA synergizes with IL-1beta to further upregulate IL-6 secretion, and this effect is shared by phenytoin and nifedipine. Nifedipine 119-129 interleukin 6 Homo sapiens 60-64 10602388-8 1999 The fluoride-induced effects on IL-6 and IL-8 release were strongly reduced by pretreatment with deferoxamine (an Al3+-chelator), and enhanced by addition of Al3+. Deferoxamine 97-109 interleukin 6 Homo sapiens 32-36 10602388-8 1999 The fluoride-induced effects on IL-6 and IL-8 release were strongly reduced by pretreatment with deferoxamine (an Al3+-chelator), and enhanced by addition of Al3+. ALUMINUM ION 114-118 interleukin 6 Homo sapiens 32-36 10602388-8 1999 The fluoride-induced effects on IL-6 and IL-8 release were strongly reduced by pretreatment with deferoxamine (an Al3+-chelator), and enhanced by addition of Al3+. ALUMINUM ION 158-162 interleukin 6 Homo sapiens 32-36 10729217-5 2000 Serum IL-6 concentration demonstrated a significant increase in the luteal phase of the MC and was elevated when serum dehydroepiandrosterone (DHEA) was low and vice versa. Dehydroepiandrosterone 119-141 interleukin 6 Homo sapiens 6-10 10729217-5 2000 Serum IL-6 concentration demonstrated a significant increase in the luteal phase of the MC and was elevated when serum dehydroepiandrosterone (DHEA) was low and vice versa. Dehydroepiandrosterone 143-147 interleukin 6 Homo sapiens 6-10 10729217-6 2000 DHEA decreased LPS-induced IL-6 secretion at six of seven time points during the MC (DHEA, p = .047). Dehydroepiandrosterone 0-4 interleukin 6 Homo sapiens 27-31 10704258-9 2000 The production of IL-1alpha, and IL-6 was inhibited by amlodipine in a concentration-dependent manner and was significantly decreased at a concentration of 10 micromol/l. Amlodipine 55-65 interleukin 6 Homo sapiens 33-37 10704258-12 2000 The unique property of amlodipine to inhibit the production of IL-1alpha, IL-1beta and IL-6 may contribute to its beneficial effects in heart failure patients. Amlodipine 23-33 interleukin 6 Homo sapiens 87-91 9629296-6 1998 In addition, catecholamines induce the production of IL-6 by leukocytes of these patients, via triggering of alpha 1-adrenergic receptors. Catecholamines 13-27 interleukin 6 Homo sapiens 53-57 10716475-8 2000 CONCLUSIONS: These findings suggest that 14 weeks of treatment with an Ang II type 1 receptor antagonist (candesartan cilexetil) decreased plasma levels of the immune markers such as TNFalpha, IL-6, sICAM-1 and sVCAM-1 and that it improved the biological compensatory action of endogenous cardiac natriuretic peptides in patients with mild to moderate CHF. candesartan cilexetil 106-127 interleukin 6 Homo sapiens 193-197 10613737-6 2000 [(3)H]Taurocholate ([(3)H]TC) uptake decreased in WIF-B cells exposed to either TNF-alpha (54% of control), IL-1beta (78%), IL-6 (55%) as single additives, or in triple combination (TCC) (43%). Technetium 26-28 interleukin 6 Homo sapiens 124-128 10613737-10 2000 Blocking antibodies against TNF-alpha, IL-1beta, and IL-6 restored the diminished [(3)H]TC uptake in cells exposed to TCC and CM to 87% and 107% of controls, respectively. Technetium 88-90 interleukin 6 Homo sapiens 53-57 10566657-0 1999 Effect of radioactive iodine therapy on cytokine production in Graves" disease: transient increases in interleukin-4 (IL-4), IL-6, IL-10, and tumor necrosis factor-alpha, with longer term increases in interferon-gamma production. radioactive iodine 10-28 interleukin 6 Homo sapiens 125-129 9593038-3 1998 The combination of GBS and lactate also enhanced the secretion of interleukin (IL)-1beta and IL-6. gbs 19-22 interleukin 6 Homo sapiens 93-97 10541915-8 1999 RESULTS: Concentrations of ILs were significantly elevated after exposure to 200 ppm 1,1,1-trichloroethane (IL-1beta 82.4 vs. 28.8 pg/ml (medians), P=0.003; IL-6 12.2 vs. 7.2 pg/ml, P=0. 1,1,1-trichloroethane 85-106 interleukin 6 Homo sapiens 157-161 10537331-8 1999 In conclusion, we show that: (a) native myeloma cells and human myeloma cell lines release sIL-6Ralpha by two distinct mechanisms: alternative splicing and proteolytic cleavage of the membrane IL-6Ralpha; and (b) the release of the sIL-6Ralpha, which is an agonist of IL-6, correlates with disease progression, explaining in part its strong prognostic value in vivo. sil-6ralpha 232-243 interleukin 6 Homo sapiens 92-96 9575969-3 1998 Chloroquine revealed a dose-dependent inhibitory effect on endotoxin-induced secretion of tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 that was associated with reduced cytokine mRNA expression. Chloroquine 0-11 interleukin 6 Homo sapiens 143-156 10479148-5 1999 Ampicillin was bacteriostatic in unstimulated cells but modestly bactericidal in cells treated with IFN-gamma and IL-6. Ampicillin 0-10 interleukin 6 Homo sapiens 114-118 10475301-10 1999 IMPLICATIONS: We found that ketamine suppressed lipopolysaccharide-induced tumor necrosis factor alpha, interleukin (IL)-6, and IL-8 production and recombinant human tumor necrosis factor-induced IL-6 and IL-8 production in human whole blood. Ketamine 28-36 interleukin 6 Homo sapiens 104-122 10475301-10 1999 IMPLICATIONS: We found that ketamine suppressed lipopolysaccharide-induced tumor necrosis factor alpha, interleukin (IL)-6, and IL-8 production and recombinant human tumor necrosis factor-induced IL-6 and IL-8 production in human whole blood. Ketamine 28-36 interleukin 6 Homo sapiens 196-200 9616381-8 1998 Preincubation with cycloheximide inhibited IL-6 but not IL-8 transcription, and incubation of stimulated cells with actinomycin D stabilized IL-8 and also IL-6 mRNA. Dactinomycin 116-129 interleukin 6 Homo sapiens 155-159 10437800-2 1999 In human mononuclear leucocytes, gal-cer but not sulfatide induced significantly increased amounts of interleukin (IL)-1beta, IL-6 and tumor necrosis factor (TNF) mRNA. Galactosylceramides 33-40 interleukin 6 Homo sapiens 126-130 10442524-10 1999 In conclusion, budesonide and fluticasone propionate, in concentrations that probably occur in the airway lining fluid during inhalational therapy, inhibited cytokine release from human lung epithelial cells (IL-6, IL-8) and alveolar macrophages (TNF-alpha, IL-6, IL-8). Budesonide 15-25 interleukin 6 Homo sapiens 209-213 10442524-10 1999 In conclusion, budesonide and fluticasone propionate, in concentrations that probably occur in the airway lining fluid during inhalational therapy, inhibited cytokine release from human lung epithelial cells (IL-6, IL-8) and alveolar macrophages (TNF-alpha, IL-6, IL-8). Budesonide 15-25 interleukin 6 Homo sapiens 258-262 10487414-0 1999 Intractable hypercalcemia due to a metastatic carcinoid secreting parathyroid hormone-related peptide and interleukin-6: response to octreotide. Octreotide 133-143 interleukin 6 Homo sapiens 106-119 10487414-4 1999 Plasma PTHrP and IL-6 fell with the octreotide but remained elevated above the upper limit of normal. Octreotide 36-46 interleukin 6 Homo sapiens 17-21 10475301-8 1999 At concentrations >100 microg/mL, ketamine also significantly suppressed both LPS-induced and rhTNF-induced IL-6 and IL-8 production. Ketamine 37-45 interleukin 6 Homo sapiens 111-115 10475301-9 1999 In this study, we demonstrated that ketamine directly inhibits the production of proinflammatory cytokines such as TNF-alpha, IL-6, and IL-8 in human whole blood. Ketamine 36-44 interleukin 6 Homo sapiens 126-130 10457265-4 1999 Treatment with 5alpha-dihydrotestosterone (DHT) dose-dependently inhibited constitutive and TNF-alpha/IL-1beta-stimulated IL-6 mRNA steady-state levels in hFOB/AR-6 cells by 70-80% at 10-7 M. In addition, testosterone also suppressed TNF-alpha/IL-1beta-stimulated IL-6 mRNA levels by 57%, while the adrenal androgen dehydroepiandrosterone had no effect. hfob 155-159 interleukin 6 Homo sapiens 122-126 10457265-4 1999 Treatment with 5alpha-dihydrotestosterone (DHT) dose-dependently inhibited constitutive and TNF-alpha/IL-1beta-stimulated IL-6 mRNA steady-state levels in hFOB/AR-6 cells by 70-80% at 10-7 M. In addition, testosterone also suppressed TNF-alpha/IL-1beta-stimulated IL-6 mRNA levels by 57%, while the adrenal androgen dehydroepiandrosterone had no effect. hfob 155-159 interleukin 6 Homo sapiens 264-268 10393680-8 1999 In explants, indomethacin 10 micromol/L or mefenamic acid 10 micromol/L abolished PGE2 secretion and significantly reduced IL-1beta and IL-6 secretion. Mefenamic Acid 43-57 interleukin 6 Homo sapiens 136-140 10397679-6 1999 Angiotensin II concentration-dependently (1 nmol/L to 1 micromol/L) stimulated IL-6 production by SMCs via activation of the angiotensin II type 1 receptor (demonstrated by the inhibitory action of the receptor antagonist losartan). Losartan 222-230 interleukin 6 Homo sapiens 79-83 10226093-1 1999 BACKGROUND: Calcium channel blockers (CCB) of all subclasses: the dihydropyridines, benzothiazepines, and phenylalkylamines, at nanomolar concentrations, have been shown to up-regulate interleukin-6 (IL-6) mRNA. phenylalkylamines 106-123 interleukin 6 Homo sapiens 185-198 9666567-5 1998 IL-2, IL-3, IL-6, and INF-alpha are able to directly stimulate glucocorticoid production by zona fasciculata and zona reticularis cells, whereas IL-1 exerts an analogous effect through an indirect mechanism involving the stimulation of catecholamine release by chromaffin cells and/or the activation of the intramedullary CRH/ACTH system; again, TNF-alpha depresses glucocorticoid synthesis. Catecholamines 236-249 interleukin 6 Homo sapiens 12-16 10226093-1 1999 BACKGROUND: Calcium channel blockers (CCB) of all subclasses: the dihydropyridines, benzothiazepines, and phenylalkylamines, at nanomolar concentrations, have been shown to up-regulate interleukin-6 (IL-6) mRNA. phenylalkylamines 106-123 interleukin 6 Homo sapiens 200-204 10226093-2 1999 We investigated the underlying molecular mechanism responsible for IL-6 induction in response to the CCB amlodipine, diltiazem, and verapamil in primary human vascular smooth muscle cells (VSMC). Amlodipine 105-115 interleukin 6 Homo sapiens 67-71 10456614-3 1999 Oncostatin-M- and interleukin-6-induced fibrinogen release was inhibited in a dose-dependent manner by ciprofibrate and, to lesser extent, by bezafibrate, fenofibric acid and clofibric acid. Bezafibrate 142-153 interleukin 6 Homo sapiens 18-31 10224600-7 1998 RESULTS: Both forms of PGPS and LPS stimulated IL-6 and IL-8 production by human fetal membranes. pgps 23-27 interleukin 6 Homo sapiens 47-51 10450786-11 1999 In stimulated monocytic cells (THP-1), lornoxicam showed a marked inhibition of IL-6 formation (IC50 54 microM) while the formation ofTNF-alpha, IL-1beta and IL-8 was only moderately affected. lornoxicam 39-49 interleukin 6 Homo sapiens 80-84 10450786-13 1999 The equipotent COX-isoenzyme inhibition by lornoxicam is complemented by a marked inhibition of IL-6 production and of iNOS-derived NO formation. lornoxicam 43-53 interleukin 6 Homo sapiens 96-100 10416955-0 1999 Interleukin-6 as a central mediator of cardiovascular risk associated with chronic inflammation, smoking, diabetes, and visceral obesity: down-regulation with essential fatty acids, ethanol and pentoxifylline. Pentoxifylline 194-208 interleukin 6 Homo sapiens 0-13 10416955-5 1999 IL-6 is released by a range of tissues in response to stimulation by the monocyte-derived cytokines interleukin-1 and tumor necrosis factor; by suppressing production of these cytokines, fish oil, alpha-linolenic acid, and pentoxifylline can reduce IL-6 synthesis. Pentoxifylline 223-237 interleukin 6 Homo sapiens 0-4 9464576-6 1997 Differential modulation of the production of IL-1beta and IL-6 was observed; amrinone and pimobendan enhanced the production of IL-1beta, whereas vesnarinone did not. pimobendan 90-100 interleukin 6 Homo sapiens 58-62 10321674-1 1999 OBJECTIVE: To evaluate the influence of the methylxanthine derivative, pentoxifylline, on plasma levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, and IL-6 in prematurely delivered infants with generalized bacterial infections and to assess the effect of this immunomodulating drug on the clinical outcome in newborns with sepsis. methylxanthine 44-58 interleukin 6 Homo sapiens 166-170 9351880-16 1997 In vitro, an increase in TNF alpha and a mild increase in IL-6 was seen with all bisphosphonates, with the greatest effects seen with the highest concentration of both pamidronate and zoledronate. Zoledronic Acid 184-195 interleukin 6 Homo sapiens 58-62 10321674-1 1999 OBJECTIVE: To evaluate the influence of the methylxanthine derivative, pentoxifylline, on plasma levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, and IL-6 in prematurely delivered infants with generalized bacterial infections and to assess the effect of this immunomodulating drug on the clinical outcome in newborns with sepsis. Pentoxifylline 71-85 interleukin 6 Homo sapiens 166-170 10321674-12 1999 Mean plasma IL-6 levels, which were measured in the pentoxifylline group on the 6th day of the study, were significantly lower compared with respective data obtained in the placebo group. Pentoxifylline 52-66 interleukin 6 Homo sapiens 12-16 10321674-15 1999 CONCLUSION: Pentoxifylline significantly affects the synthesis of TNF and IL-6 as well as reduces the mortality rate in premature infants with sepsis. Pentoxifylline 12-26 interleukin 6 Homo sapiens 74-78 10230950-8 1999 MEASUREMENTS AND MAIN RESULTS: After CPB, the concentration of the proinflammatory cytokines, interleukin-6 and interleukin-8, was significantly less in the methylprednisolone group. Methylprednisolone 157-175 interleukin 6 Homo sapiens 94-107 9396157-5 1997 All the thiazolidines examined also inhibited IL-1 alpha-induced IL-6 production with IC50 values of 10 nM order. Thiazolidines 8-21 interleukin 6 Homo sapiens 65-69 10029602-0 1999 The somatostatin analog octreotide inhibits growth of interleukin-6 (IL-6)-dependent and IL-6-independent human multiple myeloma cell lines. Octreotide 24-34 interleukin 6 Homo sapiens 54-67 10029602-0 1999 The somatostatin analog octreotide inhibits growth of interleukin-6 (IL-6)-dependent and IL-6-independent human multiple myeloma cell lines. Octreotide 24-34 interleukin 6 Homo sapiens 69-73 10029602-0 1999 The somatostatin analog octreotide inhibits growth of interleukin-6 (IL-6)-dependent and IL-6-independent human multiple myeloma cell lines. Octreotide 24-34 interleukin 6 Homo sapiens 89-93 10029602-6 1999 Octreotide inhibited the growth of both the interleukin-6 (IL-6)-dependent and the IL-6-independent MM cell lines. Octreotide 0-10 interleukin 6 Homo sapiens 44-57 10029602-6 1999 Octreotide inhibited the growth of both the interleukin-6 (IL-6)-dependent and the IL-6-independent MM cell lines. Octreotide 0-10 interleukin 6 Homo sapiens 59-63 9888462-5 1999 We have found that, although MCC is a potent inducer of IL-12 and IL-6 synthesis in monocytes and macrophages either in vitro or in vivo, it is unable to induce the synthesis of either IL-12, IL-6 or granulocyte-macrophage colony-stimulating factor (GM-CSF) by the human transitional bladder cancer cell lines HT-1197 and HT-1376. mcc 29-32 interleukin 6 Homo sapiens 66-70 10464849-1 1999 The aim of this study was to investigate the effects of pentoxifylline (PTX) on the production of TNF-alpha, IL-1 beta, IL-6 and GM-CSF by lipopolysaccharide (LPS)-stimulated alveolar macrophages (AM). Pentoxifylline 56-70 interleukin 6 Homo sapiens 120-124 10464849-1 1999 The aim of this study was to investigate the effects of pentoxifylline (PTX) on the production of TNF-alpha, IL-1 beta, IL-6 and GM-CSF by lipopolysaccharide (LPS)-stimulated alveolar macrophages (AM). Pentoxifylline 72-75 interleukin 6 Homo sapiens 120-124 10029602-6 1999 Octreotide inhibited the growth of both the interleukin-6 (IL-6)-dependent and the IL-6-independent MM cell lines. Octreotide 0-10 interleukin 6 Homo sapiens 83-87 22358879-2 1997 In this system, the transcription of hIL-6 gene under the control of PhCMV*-1 promoter composed of tetracycline operator sequences and a minimal promoter is activated by a chimeric transactivator (tTA) composed of tetracycline repressor and transactivating domain of VP16 protein of herpes simplex virus. Tetracycline 214-226 interleukin 6 Homo sapiens 37-42 10208387-5 1999 In addition, a significant difference in serum IL-6 on admission was also found (p < 0.05) between patients with TBSA of greater or less than 50%. tbsa 116-120 interleukin 6 Homo sapiens 47-51 9885879-9 1998 Plasma concentrations of EPO and IL-6 in patients with septic shock decreased significantly after PMX-F treatment (EPO, nonsurviving: 320+/-28 mlU/ml, p < 0.05; survivors: 26+/-8 mlU/ ml, p < 0.001; IL-6, nonsurviving: 3860+/-840 pg/ml, p < 0.01; survivors: 84+/-20 pg/ml, p < 0.001). pmx-f 98-103 interleukin 6 Homo sapiens 33-37 9885879-9 1998 Plasma concentrations of EPO and IL-6 in patients with septic shock decreased significantly after PMX-F treatment (EPO, nonsurviving: 320+/-28 mlU/ml, p < 0.05; survivors: 26+/-8 mlU/ ml, p < 0.001; IL-6, nonsurviving: 3860+/-840 pg/ml, p < 0.01; survivors: 84+/-20 pg/ml, p < 0.001). pmx-f 98-103 interleukin 6 Homo sapiens 205-209 22358879-5 1997 In the presence of tetracycline, the tTA transactivators can not bind to PhCMV*-1 promoter, therefore, the expression of hIL-6 and tTA gene is suppressed, and the pX will not activate basal transcription. Tetracycline 19-31 interleukin 6 Homo sapiens 121-126 9885879-10 1998 CONCLUSIONS: Plasma concentrations of EPO and IL-6 may be prognostic indicators in patients with septic shock: PMX-F treatment may be effective in reducing the plasma concentrations of EPO and IL-6 in patients with septic shock. pmx-f 111-116 interleukin 6 Homo sapiens 193-197 22358879-8 1997 Furthermore, the hIL-6 production is stringently regulated by tetracycline. Tetracycline 62-74 interleukin 6 Homo sapiens 17-22 9401927-4 1997 This IL-1 alpha, IL-1 beta, or TNF-alpha-induced IL-6 production was enhanced, but the cAMP accumulation they induced was inhibited by the addition of indomethacin. Indomethacin 151-163 interleukin 6 Homo sapiens 49-53 10052826-10 1999 The intraoperative peak values of IL-6 in LP were significantly lower than those in the OP group (P < .01). leucylproline 42-44 interleukin 6 Homo sapiens 34-38 9344885-7 1997 NHBE cells exposed to ROFA produced significant amounts of IL-8, IL-6, and TNF, as well as mRNAs coding for these cytokines. rofa 22-26 interleukin 6 Homo sapiens 65-69 9933267-10 1999 The intrathecal levels of sbcl-2 were significantly decreased during the first 3 days after stroke onset and at the same time were positively correlated with the levels of IL-6 and tumor necrosis factor-alpha. sbcl-2 26-32 interleukin 6 Homo sapiens 172-208 9719251-6 1998 Her serum interleukin 6 level was 57,359 pg/ml before PTCD, and gradually decreased to 10 pg/ml after PTCD. ptcd 54-58 interleukin 6 Homo sapiens 10-23 9719251-6 1998 Her serum interleukin 6 level was 57,359 pg/ml before PTCD, and gradually decreased to 10 pg/ml after PTCD. ptcd 102-106 interleukin 6 Homo sapiens 10-23 9719251-7 1998 Bile interleukin 6 level was 10 pg/ml before PTCD, 8997 pg/ ml 3 h after PTCD and gradually decreased there after. ptcd 45-49 interleukin 6 Homo sapiens 5-18 9719251-7 1998 Bile interleukin 6 level was 10 pg/ml before PTCD, 8997 pg/ ml 3 h after PTCD and gradually decreased there after. ptcd 73-77 interleukin 6 Homo sapiens 5-18 9385480-8 1997 Interleukin-6 and serum immunoglobulin G levels were significantly reduced in the HCQ group but not in the ZDV group. Hydroxychloroquine 82-85 interleukin 6 Homo sapiens 0-13 9671211-8 1998 Tat-induced increase in IL-6 mRNA was abolished in the presence on PK-A inhibitor H-89, demonstrating that activation of PK-A is necessary and sufficient for the increase in IL-6 production by these cells. N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide 82-86 interleukin 6 Homo sapiens 24-28 9671211-8 1998 Tat-induced increase in IL-6 mRNA was abolished in the presence on PK-A inhibitor H-89, demonstrating that activation of PK-A is necessary and sufficient for the increase in IL-6 production by these cells. N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide 82-86 interleukin 6 Homo sapiens 174-178 9651185-8 1998 The IL-6 response was inhibited by the metal chelator deferoxamine and the free radical scavenger N-acetyl-L-cysteine, suggesting that the activation of NF-kappaB may be mediated through reactive oxygen intermediates generated by transition metals found in ROFA. Deferoxamine 54-66 interleukin 6 Homo sapiens 4-8 9921985-7 1999 Both IL-6- and OM-mediated effects are inhibited by the treatment of PC-3 with an antisense oligodeoxynucleotide against gp130, the protein kinase inhibitor genistein (GNS), or the monoterpene perillic acid (PA), a posttranslational inhibitor of p21ras isoprenylation. monoterpene perillic acid 181-206 interleukin 6 Homo sapiens 5-9 12818091-4 1999 A significant reduction in sIL-6R (8 weeks) and IL-6 (18 months) was noted after therapy with methimazole. Methimazole 94-105 interleukin 6 Homo sapiens 28-32 9256485-5 1997 In a clone of M1 cells that did not express p53, vincristine or doxorubicin induced protease activation and apoptosis that were not suppressed by protease inhibitors, but were suppressed by interleukin 6. Vincristine 49-60 interleukin 6 Homo sapiens 190-203 10602444-11 1999 In control samples methylprednisolone considerably reduced stimulated and unstimulated IL-6 and TNF-alpha production in all SLE patients, irrespective of the disease state, and in all healthy controls. Methylprednisolone 19-37 interleukin 6 Homo sapiens 87-91 10440571-1 1999 We investigated the effect of FUT-175, a serine protease inhibitor, on the production of pro-inflammatory cytokines, interleukin-6 (IL-6) and interleukin-8 (IL-8), by monocytes stimulated with lipopolysaccharide (LPS). nafamostat 30-37 interleukin 6 Homo sapiens 117-130 9879973-3 1998 Whole bacterial cells and isolated PG from these strains, grown in the presence of oxacillin, showed a significantly reduced stimulation of tumour necrosis factor-alpha, interleukin (IL)-1beta and IL-6 release by human monocytes in a concentration-dependent fashion. Oxacillin 83-92 interleukin 6 Homo sapiens 197-201 10440571-1 1999 We investigated the effect of FUT-175, a serine protease inhibitor, on the production of pro-inflammatory cytokines, interleukin-6 (IL-6) and interleukin-8 (IL-8), by monocytes stimulated with lipopolysaccharide (LPS). nafamostat 30-37 interleukin 6 Homo sapiens 132-136 9253958-7 1997 TNF-alpha, interleukin-6 and interleukin-8 synthesis was maximally inhibited by 3 nM delta9-tetrahydrocannabinol but stimulated by 3 microM delta9-tetrahydrocannabinol, as was interleukin-8 and interferon-gamma synthesis. Dronabinol 85-112 interleukin 6 Homo sapiens 11-24 9646301-9 1998 Oral/enteral supplementation of EPA ethyl ester (1.8 g/d) significantly reduced the postoperative IL-6 production (P < 0.05 at 1, 2, and 6 h after operation), and improved cell-mediated immune function 3 wk after operation (P = 0.05). eicosapentaenoic acid ethyl ester 32-47 interleukin 6 Homo sapiens 98-102 9184643-1 1997 In human glioblastoma A172 cells, interleukin-6 (IL-6) production was induced by interleukin-1 beta (IL-1 beta) and dibutyryl cyclic AMP. Bucladesine 116-136 interleukin 6 Homo sapiens 34-47 9546416-5 1998 After 6 hr of high-dose PTX treatment, TNF and IL-6 levels significantly decreased while an increase in TNF and IL-6 levels was seen after 6 hr of low-dose PTX or placebo treatment (P < 0.01). Pentoxifylline 24-27 interleukin 6 Homo sapiens 47-51 9546416-5 1998 After 6 hr of high-dose PTX treatment, TNF and IL-6 levels significantly decreased while an increase in TNF and IL-6 levels was seen after 6 hr of low-dose PTX or placebo treatment (P < 0.01). Pentoxifylline 156-159 interleukin 6 Homo sapiens 112-116 9546416-7 1998 We conclude that 40 mg/kg/day of PTX reduces plasma levels of TNF, IL-6, and TNF-receptor in patients with severe malaria. Pentoxifylline 33-36 interleukin 6 Homo sapiens 67-71 9481022-13 1998 In part 2 (DTaP was substituted for DTwP), there were no elevations of IL-6 or CRP, thus indicating that whole-cell pertussis component of DTwP was responsible for IL-6 and CRP elevations. dtwp 139-143 interleukin 6 Homo sapiens 164-168 9184643-1 1997 In human glioblastoma A172 cells, interleukin-6 (IL-6) production was induced by interleukin-1 beta (IL-1 beta) and dibutyryl cyclic AMP. Bucladesine 116-136 interleukin 6 Homo sapiens 49-53 9112422-5 1997 Furthermore, we showed that specific inhibition of the cyclooxygenase pathway by indomethacin completely blocked the steroidogenic effect of IL-6 while the effect of IL-3 was not affected. Indomethacin 81-93 interleukin 6 Homo sapiens 141-145 9506463-2 1998 However DHEA (10[-9] M or 10[-12] M) in association with LPS (0.2 ng/ml) did induce the release of IL-6 and TNF. Dehydroepiandrosterone 8-12 interleukin 6 Homo sapiens 99-111 9506463-4 1998 Monocytes activated by both DHEA (10[-9] M or 1O[-12] M) and LPS (1 microg/ml) secreted IL-6 and TNF at a higher level than that observed for monocytes activated only by LPS (1 microg/ml) alone. Dehydroepiandrosterone 28-32 interleukin 6 Homo sapiens 88-92 9129099-3 1997 Imipenem and meropenem induced faster killing of E. coli than ceftriaxone at 2 and 6 h. However, imipenem-induced bacterial killing resulted in significantly less IL-6 release compared with meropenem or ceftriaxone. Meropenem 13-22 interleukin 6 Homo sapiens 163-167 9144567-3 1997 Furthermore, IL-6 mRNA accumulation stimulated by cycloheximide or anisomycin is almost completely inhibited in the presence of actinomycin D, indicating that this effect occurs mainly through the activation of the transcriptional machinery. Dactinomycin 128-141 interleukin 6 Homo sapiens 13-17 20492795-0 1998 [The response of methylprednisolon therapy to interleukin-6 release in spinal injuries.]. Methylprednisolone 17-34 interleukin 6 Homo sapiens 46-59 20492795-3 1998 We followed the influence of Methylprednisolon (Solumedrol, UpJohn) therapy to the IL-6 level in blood and liquor, as the supposed selective mediator for spinal trauma. Methylprednisolone 29-46 interleukin 6 Homo sapiens 83-87 9129911-0 1997 Left ventricular myxoma presenting with constitutional symptoms and raised serum interleukin-6 both suppressed by naproxen. Naproxen 114-122 interleukin 6 Homo sapiens 81-94 9506876-2 1998 Spontaneous and IL-1 + TNF-alpha stimulated IL-6 release was measured in supernatants of cultures of human osteoblastic osteosarcoma cells MG-63, pretreated for 4 hours with different doses of etidronate, clodronate or alendronate using a specific bioassay. Clodronic Acid 205-215 interleukin 6 Homo sapiens 44-48 9361128-1 1997 Flow cytometry was used to investigate the participation of reactive oxygen species, other than singlet oxygen, in the cytotoxic effect of photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) in vitro in A-431 squamous cell carcinoma (SCC) cells and human skin fibroblasts (HSF). 5-amino levulinic acid 171-192 interleukin 6 Homo sapiens 314-317 9488193-10 1997 In this respect, we demonstrate that amlodipine increases expression of the cytokine interleukin-6 by directly activating the respective gene promoter in human VSMC. Amlodipine 37-47 interleukin 6 Homo sapiens 85-98 9361128-1 1997 Flow cytometry was used to investigate the participation of reactive oxygen species, other than singlet oxygen, in the cytotoxic effect of photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) in vitro in A-431 squamous cell carcinoma (SCC) cells and human skin fibroblasts (HSF). 5-amino levulinic acid 194-197 interleukin 6 Homo sapiens 314-317 9398733-10 1997 In contrast, IL-6 caused significant increases in plasma glucagon levels, which peaked between 120 and 150 min after the IL-6 injection. Glucagon 57-65 interleukin 6 Homo sapiens 13-17 9398733-10 1997 In contrast, IL-6 caused significant increases in plasma glucagon levels, which peaked between 120 and 150 min after the IL-6 injection. Glucagon 57-65 interleukin 6 Homo sapiens 121-125 9361128-3 1997 Our data support the importance of the incubation time with ALA in the selectivity of PDT with ALA against SCC cells, inducing minimum damage on normal HSF. 5-amino levulinic acid 60-63 interleukin 6 Homo sapiens 152-155 9361128-3 1997 Our data support the importance of the incubation time with ALA in the selectivity of PDT with ALA against SCC cells, inducing minimum damage on normal HSF. 5-amino levulinic acid 95-98 interleukin 6 Homo sapiens 152-155 9408318-6 1997 IL-6 value increased ten fold on the first postoperative day (52.8 pg/ml) in the OC group with a return to baseline value by the fourth postoperative day. oc 81-83 interleukin 6 Homo sapiens 0-4 9282937-5 1997 Although the nonselective analogue 2-chloroadenosine (2CA) increased IL-6 secretion to a similar extent, the A1-selective agonist N6-cyclopentyladenosine or the A2a agonist CGS-21680 had only a marginal effect on IL-6 secretion. 2-Chloroadenosine 35-52 interleukin 6 Homo sapiens 69-73 8998126-1 1997 OBJECTIVE: The authors investigate the role of a variety of essential polyunsaturated fatty acids on the spontaneous and interleukin-6 stimulated production of acute phase proteins by isolated human hepatocytes. essential polyunsaturated fatty acids 60-97 interleukin 6 Homo sapiens 121-134 9323354-5 1997 Treatment with clozapine significantly increased plasma sCD8, IL-6, CC16 and IL-1RA concentrations. Clozapine 15-24 interleukin 6 Homo sapiens 62-66 9323354-6 1997 The clozapine-induced increments in plasma IL-6 and CC16 appeared during the first 2 weeks of treatment, whereas the increases in plasma sCD8 and IL-1RA appeared after 5 weeks. Clozapine 4-13 interleukin 6 Homo sapiens 43-47 9280289-3 1997 Furthermore, generating singlet oxygen outside the cells by irradiation of rose bengal-coated resin particles with visible light (lambda > 450 nm) results in the induction of interstitial collagenase, IL-1 and IL-6, similar to the response observed with UVA irradiation. Rose Bengal 75-86 interleukin 6 Homo sapiens 213-217 9002011-7 1997 RESULTS: We observed that chloroquine and hydroxychloroquine equally inhibit PHA induced TNF-alpha and IFN-gamma production, and LPS induced TNF-alpha and IL-6 production, while PHA induced IL-6 production was not affected. Chloroquine 26-37 interleukin 6 Homo sapiens 190-194 9252483-4 1997 The plasma concentrations of interleukin (IL)-6 increased from 0.75 +/- 0.19 (preexercise) to 5.02 +/- 0.96 pg/ml (2 h postexercise) in the control trial and in the BCAA supplementation trial from 1.07 +/- 0.41 to 4.15 +/- 1.21 pg/ml. Amino Acids, Branched-Chain 165-169 interleukin 6 Homo sapiens 29-47 9002011-7 1997 RESULTS: We observed that chloroquine and hydroxychloroquine equally inhibit PHA induced TNF-alpha and IFN-gamma production, and LPS induced TNF-alpha and IL-6 production, while PHA induced IL-6 production was not affected. Hydroxychloroquine 42-60 interleukin 6 Homo sapiens 190-194 9246192-7 1997 As the IL-6 promoter contains multiple binding sites for activated glucocorticoid receptors within the 5" regulatory region, the potential modulation of IL-6 expression by the corticosteroids hydrocortisone, dexamethasone and mometasone furoate was included in our study to modify the radiation-induced stress response. Mometasone Furoate 226-244 interleukin 6 Homo sapiens 7-11 9246192-7 1997 As the IL-6 promoter contains multiple binding sites for activated glucocorticoid receptors within the 5" regulatory region, the potential modulation of IL-6 expression by the corticosteroids hydrocortisone, dexamethasone and mometasone furoate was included in our study to modify the radiation-induced stress response. Mometasone Furoate 226-244 interleukin 6 Homo sapiens 153-157 9169347-8 1997 Pretreatment of cells with 17 beta-estradiol (17 beta-E2) antagonized IL-1-stimulated IL-6 production. 17 beta-e2 46-56 interleukin 6 Homo sapiens 86-90 9061040-1 1997 Cytomedical therapy for human interleukin-6 transgenic mice (hIL-6 Tgm) was implemented by the intraperitoneal injection of alginate-poly(L)lysine-alginate (APA) membranes microencapsulating SK2 hybridoma cells (APA-SK2 cells) which secrete anti-hIL-6 monoclonal antibodies (SK2 mAb). alginate-polylysine-alginate 133-155 interleukin 6 Homo sapiens 61-66 9052874-11 1996 Our study discloses a novel biologic effect of the hIL-6/hsIL-6R complex, which is clearly distinct from that of hIL-6 alone. hsil-6r 57-64 interleukin 6 Homo sapiens 51-56 9309381-2 1997 IL6 is another cytokine important in the mechanisms of bone resorption and could be a target for the actions of SK&F 86002. amicloral 112-118 interleukin 6 Homo sapiens 0-3 9309381-4 1997 Both indomethacin (5 x 10(-8)-5 x 10(-6) M) and SK&F 86002 (5 x 10(-7)-10(-5) M) markedly inhibited the IL6 release and totally inhibited resorption at all concentrations tested. amicloral 48-54 interleukin 6 Homo sapiens 108-111 9309381-6 1997 In human osteoblastic cells (SaOS2) both basal and TNF alpha-stimulated IL6 production were inhibited in a concentration-related manner by SK&F 86002 but not by indomethacin. amicloral 139-145 interleukin 6 Homo sapiens 72-75 9309381-7 1997 The effect of SK&F 86002 was greatest in 6 h cultures where relatively low levels of IL6 are produced and progressively less in 24 and 48 h cultures which produce higher levels of IL6. amicloral 14-20 interleukin 6 Homo sapiens 89-92 9309381-7 1997 The effect of SK&F 86002 was greatest in 6 h cultures where relatively low levels of IL6 are produced and progressively less in 24 and 48 h cultures which produce higher levels of IL6. amicloral 14-20 interleukin 6 Homo sapiens 184-187 9309381-9 1997 Therefore, SK&F 86002 may inhibit IL6 production in osteoblastic cells via a more direct mechanism, possibly involving inhibition of the p38 MAP kinase, the mechanism proposed for its inhibition of IL 1 beta and TNF alpha release. amicloral 11-17 interleukin 6 Homo sapiens 38-41 9076951-5 1997 Co-culture with 0.25% Iodosorb, Iodosorb conditioned medium or 20 micrograms/ml iodine enhanced TNF alpha secretion (48 +/- 3% cytotoxicity in L929 bioassay to 78 +/- 2% cytotoxicity, +/-SD) by U937 cells stimulated with sub-optimal concentrations of LPS (0.25 ng/ml) and inhibited secretion of IL-6 from cells stimulated with 10 ng/ml LPS (> 750 pg/ml to 267 +/- 52 pg/ml, +/-SD, n = 4). cadexomer iodine 22-30 interleukin 6 Homo sapiens 295-299 8982123-2 1996 In healthy individuals, catecholamines can inhibit the production of pro-inflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) via interaction with beta 2-adrenergic receptors. Catecholamines 24-38 interleukin 6 Homo sapiens 101-114 9076951-5 1997 Co-culture with 0.25% Iodosorb, Iodosorb conditioned medium or 20 micrograms/ml iodine enhanced TNF alpha secretion (48 +/- 3% cytotoxicity in L929 bioassay to 78 +/- 2% cytotoxicity, +/-SD) by U937 cells stimulated with sub-optimal concentrations of LPS (0.25 ng/ml) and inhibited secretion of IL-6 from cells stimulated with 10 ng/ml LPS (> 750 pg/ml to 267 +/- 52 pg/ml, +/-SD, n = 4). cadexomer iodine 32-40 interleukin 6 Homo sapiens 295-299 8982123-2 1996 In healthy individuals, catecholamines can inhibit the production of pro-inflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) via interaction with beta 2-adrenergic receptors. Catecholamines 24-38 interleukin 6 Homo sapiens 116-120 8982123-3 1996 In contrast, we show here that catecholamines can stimulate the production of the interleukin-6 (IL-6) in children with the chronic inflammatory disease polyarticular juvenile rheumatoid arthritis (JRA). Catecholamines 31-45 interleukin 6 Homo sapiens 82-95 9048875-4 1996 Using lipopolysaccharide (LPS)-stimulated cells, sulphatide increased the IL-2 production (163 +/- 17% of controls without sulphatide, p = 0.02), and gal-cer increased the IL-1 alpha production (145 +/- 13%, p = 0.006), whereas neither gal-cer nor sulphatide had an effect on the production of IL-6, IL-10 or TNF alpha. Galactosylceramides 150-157 interleukin 6 Homo sapiens 294-298 8982123-3 1996 In contrast, we show here that catecholamines can stimulate the production of the interleukin-6 (IL-6) in children with the chronic inflammatory disease polyarticular juvenile rheumatoid arthritis (JRA). Catecholamines 31-45 interleukin 6 Homo sapiens 97-101 8914955-4 1996 The specific uptake of 125I-7S globulin at 37 degrees C was a curvilinear function of time, and achieved equilibrium after 6 and 12 h in HSF and Hep G2 cells, respectively. 125i-7s 23-30 interleukin 6 Homo sapiens 137-140 9048875-5 1996 When stimulating cells with phytohaemagglutinin (PHA), sulphatide decreased the production of IL-6 (88 +/- 5%, p = 0.009), IL-10 (66 +/- 3%, p = 0.000003), and TNF alpha (75 +/- 9% p = 0.02). Sulfoglycosphingolipids 55-65 interleukin 6 Homo sapiens 94-98 8887280-12 1996 RNA stability experiments using actinomycin D revealed that the half life of IL-6 mRNA (hours) was increased from 2.8 hours in control cells to 6.7 and 9.4 in HPMC exposed to PDE and IL-1 beta, respectively. Dactinomycin 32-45 interleukin 6 Homo sapiens 77-81 9172015-0 1996 (+/-)-3-[4-(2-dimethylamino-1-methylethoxy)-phenyl]-1H-pyrazolo[3,4- B]pyridine-1-acetic acid (Y-25510) stimulates production of IL-1 beta and IL-6 at the level of messenger RNA expression in cultured human monocytes. Y 25510 0-93 interleukin 6 Homo sapiens 143-147 9172015-5 1996 In contrast, the stimulation of mRNA expression for IL-6 by Y-25510 was not suppressed by cycloheximide but suppressed by N alpha-p-tosyl-L-phenylalanine chloromethyl ketone (TPCK), an inhibitor of nuclear transcription factor-kappa B (NF-kappa B) activation, in the presence of LPS, suggesting that the stimulation requires NF-kappa activation. Y 25510 60-67 interleukin 6 Homo sapiens 52-56 9172015-6 1996 These results demonstrate that Y-25510 stimulates the mRNA expression for IL-1 beta and IL-6 by different mechanisms. Y 25510 31-38 interleukin 6 Homo sapiens 88-92 9172015-8 1996 The result indicates that Y-25510 stimulates the mRNA expression for IL-1 beta and IL-6 by different mechanisms from those of LPS. Y 25510 26-33 interleukin 6 Homo sapiens 83-87 9172017-0 1996 Differential regulation of TNF alpha, IL-1 beta, IL-6, IL-8, TNF beta, and IL-10 by pentoxifylline. Pentoxifylline 84-98 interleukin 6 Homo sapiens 49-53 9706914-0 1998 Ketamine attenuates the interleukin-6 response after cardiopulmonary bypass. Ketamine 0-8 interleukin 6 Homo sapiens 24-37 9706914-4 1998 In the present study, we compared the effects of adding ketamine 0.25 mg/kg to general anesthesia on serum IL-6 levels during and after elective coronary artery bypass grafting (CABG). Ketamine 56-64 interleukin 6 Homo sapiens 107-111 9706914-8 1998 Ketamine suppressed the serum IL-6 response immediately after CPB and 4, 24, and 48 h postoperatively (P < 0.05). Ketamine 0-8 interleukin 6 Homo sapiens 30-34 9706914-9 1998 During the first 7 days after surgery, the serum IL-6 levels in the ketamine group were significantly lower than those in the control group (P < 0.05). Ketamine 68-76 interleukin 6 Homo sapiens 49-53 9706914-11 1998 A single dose of ketamine 0.25 mg/kg administered before CPB suppresses the increase of serum IL-6 during and after CABG. Ketamine 17-25 interleukin 6 Homo sapiens 94-98 9172017-3 1996 We investigated PTX effects on production and mRNA expression of TNF alpha, IL-1 beta, IL-6, IL-8, TNF beta and IL-10. Pentoxifylline 16-19 interleukin 6 Homo sapiens 87-91 9706914-12 1998 IMPLICATIONS: In this randomized, double-blind, prospective study of patients during and after coronary artery bypass surgery, we examined whether small-dose ketamine added to general anesthesia before cardiopulmonary bypass suppresses the increase of the serum interleukin-6 (IL-6) concentration. Ketamine 158-166 interleukin 6 Homo sapiens 262-275 9706914-12 1998 IMPLICATIONS: In this randomized, double-blind, prospective study of patients during and after coronary artery bypass surgery, we examined whether small-dose ketamine added to general anesthesia before cardiopulmonary bypass suppresses the increase of the serum interleukin-6 (IL-6) concentration. Ketamine 158-166 interleukin 6 Homo sapiens 277-281 9706914-14 1998 Ketamine suppresses the increase of serum IL-6 during and after coronary artery bypass surgery. Ketamine 0-8 interleukin 6 Homo sapiens 42-46 9172017-7 1996 Moreover, we observed that depending on the way of activating cells, PTX induced an up- or a down-regulation (in PMA + PHA or LPS stimulated cells, respectively) for IL-1 and IL-6 release. Pentoxifylline 69-72 interleukin 6 Homo sapiens 175-179 9172017-8 1996 We also noted that the effects of PTX on IL-6, IL-8 and IL-10 production were different in WB and in PBMC culture. Pentoxifylline 34-37 interleukin 6 Homo sapiens 41-45 8822942-6 1996 Importantly, culture of MM cells with RB antisense, but not RB sense, oligonucleotide (ODN) triggered IL-6 secretion and proliferation in MM cells; however, proliferation was only partially inhibited by neutralizing anti-IL-6 monoclonal antibody (MoAb). Rubidium 38-40 interleukin 6 Homo sapiens 102-106 8729095-8 1996 In further studies, DHA dose- and time-dependently reduced also the expression of E-selectin, Intercellular Adhesion Molecule-1, interleukin (IL)-6 and IL-8, in response to IL-1, IL-4, tumor-necrosis factor, or bacterial endotoxin. Docosahexaenoic Acids 20-23 interleukin 6 Homo sapiens 129-147 9742554-7 1998 In lyophilizates containing a crystallized excipient such as glycine or mannitol, IL-6 suffered destabilization, which was less pronounced if an additional amorphous excipient was present. Mannitol 72-80 interleukin 6 Homo sapiens 82-86 9626133-0 1998 Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence. Dehydroepiandrosterone 6-28 interleukin 6 Homo sapiens 90-103 9626133-0 1998 Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence. Dehydroepiandrosterone 6-28 interleukin 6 Homo sapiens 105-109 9012164-4 1996 Interleukin-6 (IL-6) was increased only together with fever and showed a significant positive correlation with clozapine-induced fever. Clozapine 111-120 interleukin 6 Homo sapiens 0-13 8822942-6 1996 Importantly, culture of MM cells with RB antisense, but not RB sense, oligonucleotide (ODN) triggered IL-6 secretion and proliferation in MM cells; however, proliferation was only partially inhibited by neutralizing anti-IL-6 monoclonal antibody (MoAb). Rubidium 38-40 interleukin 6 Homo sapiens 221-225 9012164-4 1996 Interleukin-6 (IL-6) was increased only together with fever and showed a significant positive correlation with clozapine-induced fever. Clozapine 111-120 interleukin 6 Homo sapiens 15-19 8843757-0 1996 Exercise stimulates interleukin-6 secretion: inhibition by glucocorticoids and correlation with catecholamines. Catecholamines 96-110 interleukin 6 Homo sapiens 20-33 8843757-1 1996 In experimental animals, stress and catecholamines stimulate endogenous interleukin-6 (IL-6) secretion, whereas glucocorticoids inhibit it. Catecholamines 36-50 interleukin 6 Homo sapiens 72-85 7595543-5 1995 Calphostin C, an inhibitor of protein kinase C, also completely inhibited interleukin-6 production. calphostin C 0-12 interleukin 6 Homo sapiens 74-87 9609548-0 1998 Interleukin-6 and epidermal growth factor promote anchorage-independent growth of immortalized human prostatic epithelial cells treated with N-methyl-N-nitrosourea. Methylnitrosourea 141-163 interleukin 6 Homo sapiens 0-13 8843757-1 1996 In experimental animals, stress and catecholamines stimulate endogenous interleukin-6 (IL-6) secretion, whereas glucocorticoids inhibit it. Catecholamines 36-50 interleukin 6 Homo sapiens 87-91 9609548-3 1998 METHODS: Using growth in soft agar as an index of transformation, we examined the effect of EGF and IL-6 on the enhancement of N-methyl-N-nitrosourea (MNU)-initiated transformation of immortalized, nontumorigenic prostatic epithelial cell lines (PWR-1E and RWPE-1) developed in our laboratory. Methylnitrosourea 127-149 interleukin 6 Homo sapiens 100-104 9609548-3 1998 METHODS: Using growth in soft agar as an index of transformation, we examined the effect of EGF and IL-6 on the enhancement of N-methyl-N-nitrosourea (MNU)-initiated transformation of immortalized, nontumorigenic prostatic epithelial cell lines (PWR-1E and RWPE-1) developed in our laboratory. Methylnitrosourea 151-154 interleukin 6 Homo sapiens 100-104 8843757-6 1996 These findings suggest that IL-6 secretion is stimulated during exercise, possibly by catecholamines, whereas exogenous glucocorticoids attenuate this effect without affecting the catecholamine levels. Catecholamines 86-100 interleukin 6 Homo sapiens 28-32 9609548-4 1998 The effect of EGF and IL-6 on the growth of MNU-induced transformants isolated from soft agar was assessed both in monolayer culture and in a soft agar. Methylnitrosourea 44-47 interleukin 6 Homo sapiens 22-26 9609548-6 1998 Addition of EGF or IL-6 significantly increased colony formation in soft agar of both immortalized prostatic epithelial cell lines initiated with MNU (P < 0.001-0.05). Methylnitrosourea 146-149 interleukin 6 Homo sapiens 19-23 8843757-6 1996 These findings suggest that IL-6 secretion is stimulated during exercise, possibly by catecholamines, whereas exogenous glucocorticoids attenuate this effect without affecting the catecholamine levels. Catecholamines 86-99 interleukin 6 Homo sapiens 28-32 9609548-9 1998 Furthermore, as compared to the parental cell lines, growth response of MNU-transformants to 5alpha-dihydrotestosterone (5alpha-DHT), EGF, or IL-6 in monolayer culture was better in 5 of 8, 6 of 8, and 7 of 8 cell lines, respectively. Methylnitrosourea 72-75 interleukin 6 Homo sapiens 142-146 8575836-8 1995 Pretreatment of monocytes with rTNF enhanced, while pretreatment with PTX decreased, PPD-induced IL-6 production. Pentoxifylline 70-73 interleukin 6 Homo sapiens 97-101 9609548-11 1998 However, the degree of responsiveness to EGF or IL-6 in soft agar varied among the MNU-transformants. Methylnitrosourea 83-86 interleukin 6 Homo sapiens 48-52 8813652-6 1996 Indomethacin increased mucosal injury and enhanced the TNF generation but reduced the release of IL-6 from the gastric mucosa. Indomethacin 0-12 interleukin 6 Homo sapiens 97-101 9506551-3 1998 The activation of these pathways, one activated by IFNgamma and the other by the combination TNFalpha/IL-2/IL-6, is independent from myelin antigens and precedes by 2 weeks phases of disease activity (eg, clinical relapses and/or appearance of gadolinium-enhancing lesions on brain magnetic resonance imaging scans during 1 year of follow-up). Gadolinium 244-254 interleukin 6 Homo sapiens 107-111 7561108-9 1995 Pretreatment of EC with the tyrosine kinase inhibitor, herbimycin A, inhibited LPS-stimulated protein tyrosine phosphorylation and LPS-mediated lactic dehydrogenase release from BBMEC and IL-6 release from HBMEC in a dose-dependent manner. herbimycin 55-67 interleukin 6 Homo sapiens 188-192 8724299-4 1996 While all cytokines were markedly stimulated by IL-1 alpha), co-addition of the cyclooxygenase inhibitor indomethacin enhanced IL-8 and GMCSF levels, but caused a reduction in IL-6 expression. Indomethacin 105-117 interleukin 6 Homo sapiens 176-180 8844339-10 1995 IL-6 levels were significantly correlated with those of neopterin, whereas no correlation was found between neopterin and IL-10 values. Neopterin 56-65 interleukin 6 Homo sapiens 0-4 8576944-3 1995 Here we demonstrate that the four Ca(2+)-channel blockers, Amlodipine, Felodipine, Isradipine and Manidipine, at nanomolar concentrations, activate the transcription of the genes encoding IL-6 and IL-8 in primary human VSMC and fibroblasts. Amlodipine 59-69 interleukin 6 Homo sapiens 188-192 9452133-8 1998 There was an inverse relationship between TC and IL-6 levels, with r = -0.51 for the entire curve and r = -0.90 for the cholesterol nadir with the IL-6 peak. Technetium 42-44 interleukin 6 Homo sapiens 49-53 9452133-8 1998 There was an inverse relationship between TC and IL-6 levels, with r = -0.51 for the entire curve and r = -0.90 for the cholesterol nadir with the IL-6 peak. Technetium 42-44 interleukin 6 Homo sapiens 147-151 9452133-11 1998 There is a significant inverse correlation between TC and IL-6, suggesting a possible role of IL-6 in postoperative changes in serum lipoproteins. Technetium 51-53 interleukin 6 Homo sapiens 58-62 9452133-11 1998 There is a significant inverse correlation between TC and IL-6, suggesting a possible role of IL-6 in postoperative changes in serum lipoproteins. Technetium 51-53 interleukin 6 Homo sapiens 94-98 8528601-5 1995 When preincubated with the cells, DEL dose-dependently suppressed IL-6 release by up to 40% and IL-8 release by up to 50%. del 34-37 interleukin 6 Homo sapiens 66-70 8724299-5 1996 The addition of PGE2 to cultures stimulated with IL-1 alpha and indomethacin resulted increases in IL-6 mRNA and protein expression while causing a concomitant reduction in GMCSF protein and mRNA expression. Indomethacin 64-76 interleukin 6 Homo sapiens 99-103 8689410-7 1996 RESULTS: Significant increases in HSF binding to [32P]labeled HSE were found at 30 minutes in nuclear extract and at 4 hours in both nuclear and cytosol extracts. 5-demethylbupranolol 62-65 interleukin 6 Homo sapiens 34-37 9485518-4 1997 ONO-5046.Na significantly inhibited the production of IL-1 beta and IL-6 at the doses between 10(-9) and 10(-7) M, and TNF-alpha at the doses between 10(-9) and 10(-4) M. These results suggest that ONO-5046.Na at clinically available concentrations can inhibit the cytokine production by monocytes. sivelestat 0-8 interleukin 6 Homo sapiens 68-72 11859379-4 1996 IL-1 treatment of chondrocytes cultured in alginate resulted in increased synthesis of IL-6 and prostaglandins, but not leukotrienes. Alginates 43-51 interleukin 6 Homo sapiens 87-91 9353425-5 1997 Antibodies against IL-6 were subsequently shown to permit the development of tumoricidal function in alveolar macrophages stimulated with interferon gamma + lipopolysaccharide while IL-6 protein was shown to inhibit the stimulatory action of allogeneic lymphocytes on the development of tumoricidal function in the same alveolar macrophages. gamma + lipopolysaccharide 149-175 interleukin 6 Homo sapiens 19-23 8592085-3 1996 Transcription of IL-6 mRNA was first detectable 2 h after stimulation with the ester phorbol myristate acetate (PMA) and the calcium ionophore A23187 in both cell lines, as evidenced by semiquantitative reverse transcriptase polymerase chain reaction analysis. Esters 79-84 interleukin 6 Homo sapiens 17-21 9353425-7 1997 These results show that IL-6 can regulate the ability of alveolar macrophages from lung cancer patients to be stimulated by interferon gamma + lipopolysaccharide to develop significant tumoricidal function. gamma + lipopolysaccharide 135-161 interleukin 6 Homo sapiens 24-28 8838503-12 1996 Naproxen only slightly reduced the LPS induced expression of IL-6, while enhancing the IL-1 beta expression. Naproxen 0-8 interleukin 6 Homo sapiens 61-65 9383257-8 1997 For the dose of 10(-4) M histamine, a 50% inhibition of IL-6 secretion was obtained for a dose of DCL equal to 2.6 x 10(-12) M whereas the same magnitude of effects were only reached for a higher concentration of L (0.3 x 10[-6] M). des(ethoxycarbonyl)loratadine 98-101 interleukin 6 Homo sapiens 56-60 9368513-3 1997 Antithyroid drugs such as methimazole inhibit IL-6 production by thyrocytes but the effects of glucocorticoids and oestrogen have not been investigated. Methimazole 26-37 interleukin 6 Homo sapiens 46-50 8747002-7 1996 Exposure for 30 min to NO2 induced a significant decrease of LPS-stimulated IL-1 Beta, IL-6, IL-8, and TNF-alpha (p < .05). Nitrogen Dioxide 23-26 interleukin 6 Homo sapiens 87-91 9378738-9 1997 Phosphodiesterase inhibitors, such as isobutyryl methylxanthine and pentoxifylline, which increase intracellular levels of cAMP, caused a decrease in the production of tumor necrosis factor-alpha and an increase in the production of interleukin-6. Pentoxifylline 68-82 interleukin 6 Homo sapiens 233-246 8747002-10 1996 NO2 exposure of LPS-stimulated AM resulted in a functional impairment of AM after NO2 exposure regarding IL-1 beta, IL-6, IL-8, and TNF-alpha. Nitrogen Dioxide 0-3 interleukin 6 Homo sapiens 116-120 19856299-1 1997 This study demonstrates the changing levels of leukotrieneB4 (LTB4) and leukotrieneC4 (LTC4) generated by human white blood cells primed with different human interleukins IL-3, IL-5, IL-6, IL-8 and with human hematopoietic growth factor granulocyte-macrophage colony stimulating factor (GM-CSF). Leukotriene C4 72-85 interleukin 6 Homo sapiens 183-187 8963837-5 1996 The LCE group showed a significantly lower stress response with respect to interleukin 1 beta, interleukin 6, epinephrine, norepinephrine and glucose. LCE 4-7 interleukin 6 Homo sapiens 95-108 21432455-6 1997 Thus the change rate of sialic acids (SA) increased significantly in both the IL-6 unchanged and increased groups. N-Acetylneuraminic Acid 38-40 interleukin 6 Homo sapiens 78-82 7499316-7 1995 Similarly, increased expression of RA301 in supporting a neurotrophic function of astrocytes was suggested by inhibition of interleukin-6 elaboration, a neuroprotective cytokine, in the presence of antisense oligonucleotide for RA301. ra301 35-40 interleukin 6 Homo sapiens 124-137 9207618-2 1997 OBJECTIVES: We sought to determine whether the beneficial effects of amlodipine in heart failure may be mediated by a reduction in tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) levels. Amlodipine 69-79 interleukin 6 Homo sapiens 175-188 9207618-2 1997 OBJECTIVES: We sought to determine whether the beneficial effects of amlodipine in heart failure may be mediated by a reduction in tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) levels. Amlodipine 69-79 interleukin 6 Homo sapiens 190-194 9207618-12 1997 However, IL-6 levels were significantly lower at 26 weeks in patients treated with amlodipine versus placebo (p = 0.007 by the Wilcoxon signed-rank test). Amlodipine 83-93 interleukin 6 Homo sapiens 9-13 9207618-14 1997 CONCLUSIONS: Amlodipine lowers plasma IL-6 levels in patients with CHF. Amlodipine 13-23 interleukin 6 Homo sapiens 38-42 9207618-15 1997 The beneficial effect of amlodipine in CHF may be due to a reduction of cytokines such as IL-6. Amlodipine 25-35 interleukin 6 Homo sapiens 90-94 8597883-1 1995 We performed an open, between patients, placebo controlled study in order to evaluate the effect of the treatment with the non steroidal anti inflammatory drugs indomethacin, diclofenac and naproxen on the concentrations of the cytokines IL-1 beta and IL-6 and of the neuropeptide substance P in plasma and synovial fluid of 24 rheumatoid arthritis patients. Indomethacin 161-173 interleukin 6 Homo sapiens 252-256 8520508-3 1995 Indomethacin, a potent inhibitor of cyclo-oxygenase and of PGE2 synthesis, significantly inhibits IL-6 production (but not IL-1 production) by 35% to 90% depending on the different MM patients studied and concurrently to that of PGE2. Indomethacin 0-12 interleukin 6 Homo sapiens 98-102 9155955-0 1997 Anthralin (dithranol) in vitro inhibits human monocytes to secrete IL-6, IL-8 and TNF-alpha, but not IL-1. Anthralin 0-9 interleukin 6 Homo sapiens 67-71 7704454-1 1995 The objective of this paper was to study the effects of interleukin 4 (IL-4) and interleukin 6 (IL-6) on cartilage matrix degradation, the production of chondroitin-4-sulphate (C4S) and chondroitin-6-sulphate (C6S), metalloproteinase (stromelysin 1 = MMP-3) and metalloproteinase inhibitor (TIMP-1) production. c6s 210-213 interleukin 6 Homo sapiens 96-100 9155955-0 1997 Anthralin (dithranol) in vitro inhibits human monocytes to secrete IL-6, IL-8 and TNF-alpha, but not IL-1. Anthralin 11-20 interleukin 6 Homo sapiens 67-71 9155955-9 1997 The results show a dose-dependent inhibition of MO IL-6, IL-8, and TNF-alpha release with a half-maximal inhibitory concentration of 0.25-0.6 microgram/ml of anthralin. Anthralin 158-167 interleukin 6 Homo sapiens 51-55 9089567-1 1997 The age-related increase in circulating IL-6 levels in humans which has been attributed to a decline in DHEA production by the adrenal gland is currently attracting attention because of its possible relevance to the aetiology and management of a number of age-related clinical disorders. Dehydroepiandrosterone 104-108 interleukin 6 Homo sapiens 40-44 9089567-2 1997 The potential importance of these observations and suggestions has prompted us to perform more detailed studies on the relationship between IL-6 and DHEA. Dehydroepiandrosterone 149-153 interleukin 6 Homo sapiens 140-144 7532586-4 1995 Actinomycin D blocked the action of IL-6, suggesting that IL-6 regulated the H1, H2, H3 gene expression. Dactinomycin 0-13 interleukin 6 Homo sapiens 36-40 9089567-3 1997 Using immunoassay techniques we have found in normal healthy individuals over the age of 40 an inverse relationship between plasma DHEA levels and the presence of detectable levels of IL-6 (more than 1 pg/ml). Dehydroepiandrosterone 131-135 interleukin 6 Homo sapiens 184-188 9089567-4 1997 In vitro, studies also revealed that low dose (10(-6)-10(-8) M) of DHEA and DHEAS inhibited the production of IL-6 in unstimulated human spleen cell suspension cultures whilst enhancing its release by explant cultures of the same tissue. Dehydroepiandrosterone 67-71 interleukin 6 Homo sapiens 110-114 9089567-4 1997 In vitro, studies also revealed that low dose (10(-6)-10(-8) M) of DHEA and DHEAS inhibited the production of IL-6 in unstimulated human spleen cell suspension cultures whilst enhancing its release by explant cultures of the same tissue. Dehydroepiandrosterone 76-81 interleukin 6 Homo sapiens 110-114 9089567-6 1997 These studies suggest that there is a real, but complex relationship between IL-6 production and DHEA levels which warrants further investigation. Dehydroepiandrosterone 97-101 interleukin 6 Homo sapiens 77-81 7532586-4 1995 Actinomycin D blocked the action of IL-6, suggesting that IL-6 regulated the H1, H2, H3 gene expression. Dactinomycin 0-13 interleukin 6 Homo sapiens 58-62 7818810-7 1994 Anti-TNF-alpha and anti-IL-6 neutralizing monoclonal antibodies inhibit by over 61% SE-induced HIV replication. Selenium 84-86 interleukin 6 Homo sapiens 24-28 9189010-3 1997 The purpose of the study was to examine the serum IL-6 levels between the patients with Graves" disease (N = 47) and without (N = 29) ophthalmopathy in respect of the presence of inflammatory eye signs and thyroiditis, thyroid function and radioiodine or medical treatments. Iodine-131 240-251 interleukin 6 Homo sapiens 50-54 9048875-4 1996 Using lipopolysaccharide (LPS)-stimulated cells, sulphatide increased the IL-2 production (163 +/- 17% of controls without sulphatide, p = 0.02), and gal-cer increased the IL-1 alpha production (145 +/- 13%, p = 0.006), whereas neither gal-cer nor sulphatide had an effect on the production of IL-6, IL-10 or TNF alpha. Sulfoglycosphingolipids 49-59 interleukin 6 Homo sapiens 294-298 7811548-7 1994 DAB389-IL-6 inhibited protein synthesis in AIDS-KS-derived spindle cells at very low concentrations (IC50 of 3.4 x 10(-11) M). Potassium 48-50 interleukin 6 Homo sapiens 7-11 7811548-10 1994 Thus, DAB389-IL-6 is a potential agent for the treatment of AIDS-associated KS. Potassium 76-78 interleukin 6 Homo sapiens 13-17 7914487-9 1994 The N/O-glycosylated IL-6 was clearly as sensitive to cathepsin-G- and gamma-GT-related activities as the unglycosylated IL-6 from Escherichia coli, thus indicating that the sugar chains did not protect the cleavage sites of the two proteases on the IL-6 molecule. Sugars 174-179 interleukin 6 Homo sapiens 21-25 8986637-3 1996 Hammerhead-type ribozymes targeted against IL-6 mRNA sequences were prepared, and in vitro analyses were used to demonstrate that these molecules catalyzed the cleavage of IL-6 mRNA poly- nucleotide fragments. Polynucleotides 182-198 interleukin 6 Homo sapiens 43-47 8986637-3 1996 Hammerhead-type ribozymes targeted against IL-6 mRNA sequences were prepared, and in vitro analyses were used to demonstrate that these molecules catalyzed the cleavage of IL-6 mRNA poly- nucleotide fragments. Polynucleotides 182-198 interleukin 6 Homo sapiens 172-176 7914487-9 1994 The N/O-glycosylated IL-6 was clearly as sensitive to cathepsin-G- and gamma-GT-related activities as the unglycosylated IL-6 from Escherichia coli, thus indicating that the sugar chains did not protect the cleavage sites of the two proteases on the IL-6 molecule. Sugars 174-179 interleukin 6 Homo sapiens 121-125 7914487-9 1994 The N/O-glycosylated IL-6 was clearly as sensitive to cathepsin-G- and gamma-GT-related activities as the unglycosylated IL-6 from Escherichia coli, thus indicating that the sugar chains did not protect the cleavage sites of the two proteases on the IL-6 molecule. Sugars 174-179 interleukin 6 Homo sapiens 121-125 8041811-2 1994 We here provide evidence that UVA-induced IL-1 alpha and IL-1 beta play a central role in the induction of the synthesis both of IL-6 and collagenase/MMP-1. uva 30-33 interleukin 6 Homo sapiens 129-149 8889915-7 1996 However, increases in TNF-alpha and sIL-2r levels were more pronounced in patients with clozapine-induced fever who showed in addition increased plasma IL-6 levels and granulocyte counts. Clozapine 88-97 interleukin 6 Homo sapiens 152-156 7511596-10 1994 Cimetidine and ranitidine, H2 receptor antagonists structurally unrelated to each other, completely reversed the histamine-mediated increase in IL-1 alpha-induced IL-6 synthesis. Cimetidine 0-10 interleukin 6 Homo sapiens 163-167 8898426-2 1996 The aim of this study was to investigate serum neopterin, a useful in vivo marker of macrophage activation, in mild and severe AP and its relationship with other markers of leukocyte activation, such as interleukin-6 (IL-6) and tumor necrosis factor (TNF). Neopterin 47-56 interleukin 6 Homo sapiens 203-216 8898426-2 1996 The aim of this study was to investigate serum neopterin, a useful in vivo marker of macrophage activation, in mild and severe AP and its relationship with other markers of leukocyte activation, such as interleukin-6 (IL-6) and tumor necrosis factor (TNF). Neopterin 47-56 interleukin 6 Homo sapiens 218-222 8198453-0 1994 [Fluticasone propionate reduced the production of GM-CSF, IL-6 and IL-8 generated from cultured nasal epithelial cells]. Fluticasone 1-23 interleukin 6 Homo sapiens 58-62 8880895-4 1996 However, the addition of IL-6 to a medium containing LPS, IL-1 beta, or TNF alpha significantly inhibited the stimulatory effect of those substances on PGI2 production. Epoprostenol 152-156 interleukin 6 Homo sapiens 25-29 8666148-4 1996 Both IL-6 and TNF-alpha mRNA levels and immunoreactivity were significantly increased by treatment with 33 mmol/l glucose compared with treatment with 11 mmol/l glucose or 11 mmol/l glucose with 22 mmol/l mannitol. Mannitol 205-213 interleukin 6 Homo sapiens 5-9 7614991-6 1995 Also, the release of IL-6, but not of TNF-alpha, by PP EC was significantly increased. pp ec 52-57 interleukin 6 Homo sapiens 21-25 7870342-0 1994 Interleukin-6 production induced in peripheral blood mononuclear cells by a serum factor from IgA nephropathy patients is inhibited in vitro by specific sugars. Sugars 153-159 interleukin 6 Homo sapiens 0-13 7733868-6 1995 Addition of sorbitol to the hypotonic medium abolished HSF activation. Sorbitol 12-20 interleukin 6 Homo sapiens 55-58 7733868-7 1995 Hypo-osmotic stress-induced HSF binding could also be demonstrated in HeLa cells maintained in simple sorbitol solution by decreasing the sorbitol concentration from 300 mM to 200 mM or less. Sorbitol 102-110 interleukin 6 Homo sapiens 28-31 8355691-5 1993 HSF activation in response to treatment with sodium arsenite or the proline analog azetidine was also depressed in hsp70-expressing cells relative to that in the nontransfected control cells. Proline 68-75 interleukin 6 Homo sapiens 0-3 7733868-7 1995 Hypo-osmotic stress-induced HSF binding could also be demonstrated in HeLa cells maintained in simple sorbitol solution by decreasing the sorbitol concentration from 300 mM to 200 mM or less. Sorbitol 138-146 interleukin 6 Homo sapiens 28-31 7695204-4 1995 IL-6 and TNF-alpha levels of culture supernatants incubated with 22 mM or 33 mM glucose showed considerable increase over basal levels incubated with 11 mM glucose, whereas those levels incubated with high concentration of mannitol showed no increase. Mannitol 223-231 interleukin 6 Homo sapiens 0-4 8548203-4 1995 Administration of PTX to septic patients resulted in the normalization of TNF synthesis and in a moderate decrease in IL-6 production. Pentoxifylline 18-21 interleukin 6 Homo sapiens 118-122 8796788-1 1996 The objective of this study was to characterize interleukin-1, -6, and -8 (IL-1-, IL-6-, and IL-8)-induced prostacyclin (PGI2 as 6-keto PGF1 alpha) and prostaglandin E2 (PGE2) production in primary cultures of human myometrial cells. Epoprostenol 107-119 interleukin 6 Homo sapiens 82-86 8796788-1 1996 The objective of this study was to characterize interleukin-1, -6, and -8 (IL-1-, IL-6-, and IL-8)-induced prostacyclin (PGI2 as 6-keto PGF1 alpha) and prostaglandin E2 (PGE2) production in primary cultures of human myometrial cells. Epoprostenol 121-125 interleukin 6 Homo sapiens 82-86 8652370-8 1996 Among the cytokines produced by KM-101 cells, it was postulated that IL-6 mediated this inhibitory effect because anti-IL-6 monoclonal antibody (MoAb) and anti-IL-6 receptor MoAb significantly reversed the inhibition. km-101 32-38 interleukin 6 Homo sapiens 69-73 8652370-8 1996 Among the cytokines produced by KM-101 cells, it was postulated that IL-6 mediated this inhibitory effect because anti-IL-6 monoclonal antibody (MoAb) and anti-IL-6 receptor MoAb significantly reversed the inhibition. km-101 32-38 interleukin 6 Homo sapiens 119-123 8652370-8 1996 Among the cytokines produced by KM-101 cells, it was postulated that IL-6 mediated this inhibitory effect because anti-IL-6 monoclonal antibody (MoAb) and anti-IL-6 receptor MoAb significantly reversed the inhibition. km-101 32-38 interleukin 6 Homo sapiens 119-123 8336306-0 1993 Selective regulation of cytokine secretion by hydroxychloroquine: inhibition of interleukin 1 alpha (IL-1-alpha) and IL-6 in human monocytes and T cells. Hydroxychloroquine 46-64 interleukin 6 Homo sapiens 117-121 8973087-6 1996 Initial elevation and steady decline of IL-6 concentrations were seen after surgical injury, and this response related significantly to post-operative norepinephrine and glucagon levels throughout the study period, and to insulin levels only at the end of surgery. Glucagon 170-178 interleukin 6 Homo sapiens 40-44 7818568-12 1995 CONCLUSION: Tenidap was differentiated from piroxicam by lower levels of acute-phase proteins, ESR, and IL-6 after tenidap treatment. Piroxicam 44-53 interleukin 6 Homo sapiens 104-108 8336306-3 1993 Hydroxychloroquine inhibited production of IL-1-alpha (monocytes) and IL-6 (T cells and monocytes). Hydroxychloroquine 0-18 interleukin 6 Homo sapiens 70-74 7974717-1 1994 Reverse transcriptase-polymerase chain reaction showed that interleukin 3, IL-4, IL-5, IL-6, interferon-gamma and stem cell factor mRNA expression were higher in 15-deoxyspergualin-treated spleen cells than in control spleen cells. gusperimus 165-180 interleukin 6 Homo sapiens 87-91 8476047-8 1993 When the cyclooxygenase inhibitor indomethacin (10 microM) was added to cultures, the production of PGE2 by KC was prevented, and in arginine-depleted cultures, IL-1 and IL-6 production was upregulated (P < 0.05). Indomethacin 34-46 interleukin 6 Homo sapiens 170-174 8967788-5 1996 Il-6 levels were slightly elevated in the supernatants obtained from psoriatic and control keratinocyte cultures after lithium treatment, but IFN gamma and Il-2 levels were elevated only in the lithium-treated cocultures with psoriatic keratinocytes. Lithium 119-126 interleukin 6 Homo sapiens 0-4 8496855-1 1993 OBJECTIVE: To determine the clinical utility and the effect of sodium aurothiomalate (GSTM) on serum interleukin 6 (IL-6) levels in patients with rheumatoid arthritis (RA). gstm 86-90 interleukin 6 Homo sapiens 101-114 7515809-3 1994 Herbimycin A and genistein, inhibitors of tyrosine kinases, markedly attenuated LPS-induced tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) protein and mRNA production. herbimycin 0-12 interleukin 6 Homo sapiens 136-149 7515809-3 1994 Herbimycin A and genistein, inhibitors of tyrosine kinases, markedly attenuated LPS-induced tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) protein and mRNA production. herbimycin 0-12 interleukin 6 Homo sapiens 151-155 8496855-1 1993 OBJECTIVE: To determine the clinical utility and the effect of sodium aurothiomalate (GSTM) on serum interleukin 6 (IL-6) levels in patients with rheumatoid arthritis (RA). gstm 86-90 interleukin 6 Homo sapiens 116-120 8509668-6 1993 Amniotic fluid concentrations of TNF-alpha, IL-1 beta and IL-6 in cases of term elective C/S were 22.8 +/- 19.2 pg/ml, 8.1 +/- 5.2 pg/ml and 166.8 +/- 126.1 pg/ml, respectively. Sulfur 91-92 interleukin 6 Homo sapiens 58-62 8583822-11 1996 Interleukin-6 levels decreased more significantly 12 and 24 hours after declamping in patients undergoing heart transplantation, probably related to methylprednisolone therapy. Methylprednisolone 149-167 interleukin 6 Homo sapiens 0-13 8372675-12 1993 Urinary IL-6 levels were significantly elevated in KD patients with pyuria and/or proteinuria (156.6 +/- 77.7 pg/mg Cr) and undetectable in the group without pyuria and proteinuria and controls during the first week. Chromium 116-118 interleukin 6 Homo sapiens 8-12 8834013-7 1996 Reductions in circulating IL-6 and sIL-2R concentrations have also been observed with cyclosporin and corticosteroids, whereas azathioprine reduces IL-6 but not sIL-2R. Azathioprine 127-139 interleukin 6 Homo sapiens 148-152 8722494-11 1996 MK-886 also inhibited synovial production of two other pleiotrophic cytokines which it regulates, IL-6 and IL-8. MK-886 0-6 interleukin 6 Homo sapiens 98-102 8015309-2 1994 Although pentoxifylline (PTX) is known to attenuate endotoxin and tumor necrosis factor (TNF)-induced lung injury, as well as decrease interleukin-6 (IL-6) levels following hemorrhage and resuscitation, it remains unknown if this agent has any beneficial effects against O2-induced lung injury. Pentoxifylline 9-23 interleukin 6 Homo sapiens 135-148 8015309-2 1994 Although pentoxifylline (PTX) is known to attenuate endotoxin and tumor necrosis factor (TNF)-induced lung injury, as well as decrease interleukin-6 (IL-6) levels following hemorrhage and resuscitation, it remains unknown if this agent has any beneficial effects against O2-induced lung injury. Pentoxifylline 9-23 interleukin 6 Homo sapiens 150-154 8015309-2 1994 Although pentoxifylline (PTX) is known to attenuate endotoxin and tumor necrosis factor (TNF)-induced lung injury, as well as decrease interleukin-6 (IL-6) levels following hemorrhage and resuscitation, it remains unknown if this agent has any beneficial effects against O2-induced lung injury. Pentoxifylline 25-28 interleukin 6 Homo sapiens 150-154 8015309-8 1994 The supernatant LDH activity, protein content, pleural fluid accumulation, and IL-6 concentration were significantly decreased (P < 0.05) in those animals pretreated with PTX prior to exposure to hyperoxia compared to those animals exposed to hyperoxia and not treated. Pentoxifylline 174-177 interleukin 6 Homo sapiens 79-83 8128185-6 1994 Similar to target-binding of untreated LAK cells, the binding between IL-6-treated LAK cells and target cells is dependent on Mg++. Magnesium 126-130 interleukin 6 Homo sapiens 70-74 8128185-10 1994 However, MoAbs to CD11a/CD18 and CD54 reduce both target-conjugation and cytotoxicity of IL-6-enhanced LAK cells to the same level as control LAK cells treated with the MoAbs. Antibodies, Monoclonal 9-14 interleukin 6 Homo sapiens 89-93 8523572-6 1996 IL-6 induction by EBV was inhibited with the PKC-specific inhibitor bisindolylmaleimide or the protein tyrosine kinase inhibitors methyl 2,5-dihydroxycinnamate and herbimycin A, indicating that the induction of IL-6 following CD21 cross-linking is mediated through PKC- and protein tyrosine kinase-dependent pathways. herbimycin 164-176 interleukin 6 Homo sapiens 0-4 8408066-4 1993 Surprisingly, IL-6 carrying a COOH-terminal extension of the amino acids Lys-Asp-Glu-Leu (KDEL) was not completely retained in the endoplasmic reticulum (ER). kdel 90-94 interleukin 6 Homo sapiens 14-18 8440709-2 1993 Recombinant human 125I-interleukin-6 (IL-6) was cross-linked with the homobifunctional reagent disuccinimidyl suberate to human hepatoma cells (HepG2). disuccinimidyl 95-109 interleukin 6 Homo sapiens 18-36 8819279-6 1996 The comparative monitoring of systemic cytokine and cytokine antagonist levels, in particular the liberation of IL-1ra and IL-6 may provide useful parameters for the development of new liver preservation theories for LTx. Leukotriene C4 217-220 interleukin 6 Homo sapiens 123-127 7575694-8 1995 Significant reductions in plasma IL-6 levels were observed at weeks 4, 12, and 24 within the tenidap group, and at week 24 within the hydroxychloroquine-plus-piroxicam-treated group. Piroxicam 158-167 interleukin 6 Homo sapiens 33-37 8440709-2 1993 Recombinant human 125I-interleukin-6 (IL-6) was cross-linked with the homobifunctional reagent disuccinimidyl suberate to human hepatoma cells (HepG2). disuccinimidyl 95-109 interleukin 6 Homo sapiens 38-42 8311921-4 1993 Consequently, the present study was designed to determine the relative contribution of the TC and VC compartments to placental IL-6 production. Technetium 91-93 interleukin 6 Homo sapiens 127-131 8311921-10 1993 Although production rates of IL-6 were 8.4-fold higher in TC compared to VC (P < .05), steady-state IL-6 mRNA expression was 3.5-fold higher in freshly isolated VC compared to TC (P < .0001) and 13-fold higher in VC compared to TC (P < .01) after 24 h in culture. Technetium 58-60 interleukin 6 Homo sapiens 29-33 8380280-6 1993 After stimulation with LPS-S, the largest quantity of TNF-alpha and IL-1 alpha released was less than that obtained after stimulation with LPS-R at the same concentration, while the quantity of IL-6 released was found to be slightly higher than that obtained after stimulation with porins or LPS-R. LPS-S (1 microgram/ml) induces IFN-gamma release from lymphocytes in notably smaller quantities than that obtained with LPS-R and slightly larger quantities than that obtained with porins. Sulfur 25-26 interleukin 6 Homo sapiens 194-198 8311921-11 1993 CONCLUSIONS: These results demonstrate that: (1) the placenta can produce large quantities of immunoreactive IL-6 in vitro, (2) TC produce significantly more IL-6 than VC although both compartments contribute to placental IL-6 production, (3) placental IL-6 production and secretion are probably posttranscriptionally regulated since steady-state IL-6 mRNA expression in VC and TC compartments did not correlate with IL-6 production. Technetium 128-130 interleukin 6 Homo sapiens 109-113 8311921-11 1993 CONCLUSIONS: These results demonstrate that: (1) the placenta can produce large quantities of immunoreactive IL-6 in vitro, (2) TC produce significantly more IL-6 than VC although both compartments contribute to placental IL-6 production, (3) placental IL-6 production and secretion are probably posttranscriptionally regulated since steady-state IL-6 mRNA expression in VC and TC compartments did not correlate with IL-6 production. Technetium 128-130 interleukin 6 Homo sapiens 158-162 8311921-11 1993 CONCLUSIONS: These results demonstrate that: (1) the placenta can produce large quantities of immunoreactive IL-6 in vitro, (2) TC produce significantly more IL-6 than VC although both compartments contribute to placental IL-6 production, (3) placental IL-6 production and secretion are probably posttranscriptionally regulated since steady-state IL-6 mRNA expression in VC and TC compartments did not correlate with IL-6 production. Technetium 128-130 interleukin 6 Homo sapiens 158-162 8311921-11 1993 CONCLUSIONS: These results demonstrate that: (1) the placenta can produce large quantities of immunoreactive IL-6 in vitro, (2) TC produce significantly more IL-6 than VC although both compartments contribute to placental IL-6 production, (3) placental IL-6 production and secretion are probably posttranscriptionally regulated since steady-state IL-6 mRNA expression in VC and TC compartments did not correlate with IL-6 production. Technetium 128-130 interleukin 6 Homo sapiens 158-162 8311921-11 1993 CONCLUSIONS: These results demonstrate that: (1) the placenta can produce large quantities of immunoreactive IL-6 in vitro, (2) TC produce significantly more IL-6 than VC although both compartments contribute to placental IL-6 production, (3) placental IL-6 production and secretion are probably posttranscriptionally regulated since steady-state IL-6 mRNA expression in VC and TC compartments did not correlate with IL-6 production. Technetium 128-130 interleukin 6 Homo sapiens 158-162 8311921-11 1993 CONCLUSIONS: These results demonstrate that: (1) the placenta can produce large quantities of immunoreactive IL-6 in vitro, (2) TC produce significantly more IL-6 than VC although both compartments contribute to placental IL-6 production, (3) placental IL-6 production and secretion are probably posttranscriptionally regulated since steady-state IL-6 mRNA expression in VC and TC compartments did not correlate with IL-6 production. Technetium 128-130 interleukin 6 Homo sapiens 158-162 8845742-4 1995 in the human microglia cells ammonia decreased the constitutive secretion of interleukin-6, but it enhanced the stimulated (interleukin-1 alpha, tumor necrosis factor-alpha, gamma-interferon and gamma-interferon + tumor necrosis factor-alpha) secretion of interleukin-8. Ammonia 29-36 interleukin 6 Homo sapiens 77-90 7642293-5 1995 The synthesis of IL-6 and IL-8 was also stimulated by 10 and 100 micrograms of both LPSs per ml, but IL-8 synthesis was not stimulated with E-LPS at 1 microgram/ml. lpss 84-88 interleukin 6 Homo sapiens 17-21 7581271-2 1995 Herbimycin A and H-7, inhibitors of tyrosine kinases and protein kinase C (PKC), markedly inhibited IL-6 production, gene expression, and tyrosine and serine/threonine phosphorylation of proteins. herbimycin 0-12 interleukin 6 Homo sapiens 100-104 8393800-4 1993 This induction of IL-6 production could be achieved by reagents known to increase intracellular levels of cAMP, such as forskolin, prostaglandin E or pentoxifylline. Pentoxifylline 150-164 interleukin 6 Homo sapiens 18-22 1332971-1 1992 Transcription of interleukin-6 (IL-6) gene in human HepG2 and HeLa cells was induced by treatment with interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-alpha), phorbol 12-myristate 13-acetate, or dibutyryl cyclic AMP. Bucladesine 202-222 interleukin 6 Homo sapiens 17-30 7505000-3 1993 The expression of tumour necrosis factor (TNF)alpha, TNF beta interleukin (IL)-2 and interferon (IFN)gamma was inhibited by PTX in a dose-dependent manner, whereas expression of IL-1 alpha, IL-1 beta, and IL-6 was unaffected at concentrations up to 300 microM of PTX. Pentoxifylline 124-127 interleukin 6 Homo sapiens 205-209 7551718-0 1995 Dehydroepiandrosterone modulates the spontaneous and IL-6 stimulated fibrinogen production of human hepatoma cells. Dehydroepiandrosterone 0-22 interleukin 6 Homo sapiens 53-57 7551718-1 1995 The role of an androgen, dehydroepiandrosterone (DHEA) has been studied on the constitutive and IL-6 induced fibrinogen production of HepG-2 cells. Dehydroepiandrosterone 25-47 interleukin 6 Homo sapiens 96-100 7551718-1 1995 The role of an androgen, dehydroepiandrosterone (DHEA) has been studied on the constitutive and IL-6 induced fibrinogen production of HepG-2 cells. Dehydroepiandrosterone 49-53 interleukin 6 Homo sapiens 96-100 1332971-1 1992 Transcription of interleukin-6 (IL-6) gene in human HepG2 and HeLa cells was induced by treatment with interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-alpha), phorbol 12-myristate 13-acetate, or dibutyryl cyclic AMP. Bucladesine 202-222 interleukin 6 Homo sapiens 32-36 7664026-7 1995 Patients treated with MTX or IMG presented an increased level of IL-10 and decreased amounts of IL-6, as compared to those treated with NSAID only. wyosine 29-32 interleukin 6 Homo sapiens 96-100 8500916-0 1993 Production of interleukin-6 by human and murine mononuclear leukocytes stimulated with Plasmodium antigens is enhanced by pentoxifylline, and tumor necrosis factor secretion is reduced. Pentoxifylline 122-136 interleukin 6 Homo sapiens 14-27 8500916-1 1993 When pentoxifylline was present during stimulation of human mononuclear leukocytes with Plasmodium falciparum exogenous antigens, an increase in interleukin-6 production was observed simultaneously with a reduction of tumor necrosis factor secretion. Pentoxifylline 5-19 interleukin 6 Homo sapiens 145-158 1331181-3 1992 At a concentration of 1% (vol/vol), DMSO blocked IL-8 release by approximately 90% in the presence of 1 microgram/ml LPS at a 24-h time point, but did not affect cell viability or reduce the production of tumor necrosis factor (TNF), interleukin 6, or interleukin-1 beta (IL-1 beta). Dimethyl Sulfoxide 36-40 interleukin 6 Homo sapiens 234-247 1630586-8 1992 CLO also suppressed IL-6-induced CRF release with a minimal effective dose of 10(-9) M. Suppression was complete at 10(-7) and 10(-5) M.(ABSTRACT TRUNCATED AT 250 WORDS) clo 0-3 interleukin 6 Homo sapiens 20-24 8699873-15 1995 In the PTX group the following variables were improved compared with the placebo group: CD11b expression on PMNs, elastase released from PMNs, fibrinogen, CRP, TNF-alpha, and IL6 in plasma. Pentoxifylline 7-10 interleukin 6 Homo sapiens 175-178 7731159-9 1995 Under these conditions short term exposure to PDF pH 5.2 followed by "in vitro dialysis" resulted in significant inhibition of cytokine stimulated IL-6 (69.6 +/- 18.2 vs. 96.7 +/- 27.9 pg/microgram, N = 13; P < 0.020 for IL-1 beta) and 6-keto-PGF1 alpha (197.5 +/- 89.2 vs. 289.6 +/- 114.5 pg/microgram, N = 13; P < 0.020 for IL-1 beta) and 6-keto-PGF1 alpha (197.5 +/- 89.2 vs. 289.6 +/- 114.5 pg/microgram, N = 13; P < 0.003) release when compared to cells incubated in control medium. pdf 46-49 interleukin 6 Homo sapiens 147-151 7623608-1 1995 The effects of elevated glucose and eicosapentaenoic acid (EPA, C20:5 omega 3) on myo-inositol uptake in human skin fibroblasts (HSF) were evaluated. Inositol 82-94 interleukin 6 Homo sapiens 129-132 1330331-2 1992 Eriochrome Blue SE was employed to visualize the subcellular distribution of Mg2+ following co-incubation of Human Foreskin Fibroblasts (HSF) with Mg2+ alone or with the Mg2+/poly r(A-U) combination. eriochrome blue 0-15 interleukin 6 Homo sapiens 137-140 1424334-3 1992 Serial studies of serum IL-6 levels in two patients revealed the increase before the exacerbation of clinical symptoms of edema, and pleural or cardiac effusion, and the fall after the treatment by high dose pulsed methylprednisolone. Methylprednisolone 215-233 interleukin 6 Homo sapiens 24-28 1569208-10 1992 Conversely, in studies that lowered ATP stores at normal pH (high K+/nigericin) we found induction of HSF-DNA binding activity. Nigericin 69-78 interleukin 6 Homo sapiens 102-105 1400875-6 1992 Additionally, treatment of chorion cells with IL-1 beta in combination with actinomycin-D or cycloheximide attenuated the stimulatory action of IL-1 beta on IL-6 production. Dactinomycin 76-89 interleukin 6 Homo sapiens 157-161 1367012-3 1991 The KEX2-type processing signal, Lys-Arg, is recognized and cleaved efficiently by an enzyme present in A. nidulans resulting in the secretion of an authentic mature hIL-6 protein at levels of up to 5 mg/l. Lys-Arg 33-40 interleukin 6 Homo sapiens 166-171 7962549-7 1994 We conclude that the expression of human IL-6 in the airways of transgenic mice results in a CD4+, MHC class II+, B220+ lymphocytic infiltrate surrounding large and mid-sized airways that does not alter basal respiratory resistance, but does diminish airway reactivity to methacholine. Methacholine Chloride 272-284 interleukin 6 Homo sapiens 41-45 7930619-9 1994 Furthermore, only 2-chloroadenosine, but not NECA, strongly inhibited cytokine-induced IL-6 and IL-8 production. 2-Chloroadenosine 18-35 interleukin 6 Homo sapiens 87-91 1505915-0 1992 Differential effects of chenodeoxycholic and ursodeoxycholic acids on interleukin 1, interleukin 6 and tumor necrosis factor-alpha production by monocytes. chenodeoxycholic 24-40 interleukin 6 Homo sapiens 85-130 7835945-0 1994 Pentoxifylline in vivo down-regulates the release of IL-1 beta, IL-6, IL-8 and tumour necrosis factor-alpha by human peripheral blood mononuclear cells. Pentoxifylline 0-14 interleukin 6 Homo sapiens 64-68 7835945-2 1994 There is also recent evidence that PTX may influence other inflammatory cytokines, such as interleukin-1 (IL-1) and IL-6. Pentoxifylline 35-38 interleukin 6 Homo sapiens 116-120 2049864-3 1991 In three patients with Castleman"s disease, in whom serum interleukin 6 (IL-6) levels were elevated, agalactosyl species of serum IgG oligosaccharides were markedly increased as compared to those of normal healthy controls. agalactosyl species 101-120 interleukin 6 Homo sapiens 58-71 2049864-3 1991 In three patients with Castleman"s disease, in whom serum interleukin 6 (IL-6) levels were elevated, agalactosyl species of serum IgG oligosaccharides were markedly increased as compared to those of normal healthy controls. agalactosyl species 101-120 interleukin 6 Homo sapiens 73-77 7835945-3 1994 Due to the therapeutic implications, the present study addressed the in vivo effects of PTX on the release of TNF-alpha, IL-1 beta, IL-6 and IL-8 by human peripheral blood mononuclear cells (PBMC). Pentoxifylline 88-91 interleukin 6 Homo sapiens 132-136 1642659-3 1992 METHODS: Anti-IL-6 IgG autoantibodies were measured by the 125I-IL-6 binding activity of IgG, which was isolated from serum by protein A-Sepharose. Sepharose 137-146 interleukin 6 Homo sapiens 14-18 7835945-4 1994 When PBMC were obtained from healthy volunteers ingesting 5 x 400 mg PTX orally for 2 days, the ability of PBMC cultured for 24 hr to release TNF-alpha was significantly reduced, while secretion of IL-1 beta, IL-6 and IL-8 was not affected. Pentoxifylline 69-72 interleukin 6 Homo sapiens 209-213 7835945-8 1994 Under these conditions, only TNF-alpha was found to be reduced by PTX, while IL-1 beta and IL-8 were not affected, IL-6 was even enhanced. Pentoxifylline 66-69 interleukin 6 Homo sapiens 115-119 7835945-9 1994 However, when PBMC were incubated with PTX for 24 hr, PTX removed thereafter by medium change and cells further cultured, the production not only of TNF-alpha but also of IL-1 beta, IL-6 and IL-8 was reduced, demonstrating that PTX exerts diverse (inhibitory) effects on cytokine release by PBMC. Pentoxifylline 39-42 interleukin 6 Homo sapiens 182-186 7835945-9 1994 However, when PBMC were incubated with PTX for 24 hr, PTX removed thereafter by medium change and cells further cultured, the production not only of TNF-alpha but also of IL-1 beta, IL-6 and IL-8 was reduced, demonstrating that PTX exerts diverse (inhibitory) effects on cytokine release by PBMC. Pentoxifylline 54-57 interleukin 6 Homo sapiens 182-186 7835945-9 1994 However, when PBMC were incubated with PTX for 24 hr, PTX removed thereafter by medium change and cells further cultured, the production not only of TNF-alpha but also of IL-1 beta, IL-6 and IL-8 was reduced, demonstrating that PTX exerts diverse (inhibitory) effects on cytokine release by PBMC. Pentoxifylline 54-57 interleukin 6 Homo sapiens 182-186 2031968-8 1991 In patients with monoclonal gammopathies including MGUS, serum IL-6 levels correlated with neopterin, tumor necrosis factor alpha and beta 2-microglobulin. Neopterin 91-100 interleukin 6 Homo sapiens 63-67 33793190-2 2021 SPEs are functionalized with antibodies specific for IL-6 through electrodeposition of a diazonium linking group and N"-ethylcarbodiimide hydrochloride (EDC) coupling, which was tracked through the use of cyclic voltammetry and Raman spectroscopy. ethylene dichloride 153-156 interleukin 6 Homo sapiens 53-57 1729367-5 1992 Indeed, an increase in IL-6 production was observed after exposure to naproxen. Naproxen 70-78 interleukin 6 Homo sapiens 23-27 33822828-4 2021 Age-stratified analyses of uninfected, asymptomatic Malian individuals before the malaria season revealed that monocytes of adults produced lower levels of inflammatory cytokines (IL-1beta, IL-6 and TNF) in response to Pf-iRBC stimulation compared to monocytes of Malian children and malaria-naive U.S. adults. pf-irbc 219-226 interleukin 6 Homo sapiens 190-194 33822828-5 2021 Moreover, monocytes of Malian children produced lower levels of IL-1beta and IL-6 following Pf-iRBC stimulation compared to 4-6-month-old infants. pf-irbc 92-99 interleukin 6 Homo sapiens 77-81 21559655-0 1994 The selective anticancer agent pb-100 inhibits interleukin-6 induced enhancement of glioblastoma cell-proliferation in-vitro. flavopereirine 31-37 interleukin 6 Homo sapiens 47-60 21559655-8 1994 PB-100 should therefore find its place in therapies requiring control of IL-6 production. flavopereirine 0-6 interleukin 6 Homo sapiens 73-77 1294622-6 1992 Among the lincosamides, clindamycine notably stimulated the release of TNF and IL-6, while lincomycine induced a notable increment of IL-4 from monocytes. Clindamycin 24-36 interleukin 6 Homo sapiens 79-83 8067274-6 1994 We conclude that: (a) schizophrenia in younger people is accompanied by increased IL-6 and sIL-2R secretion; and (b) subchronic treatment with clozapine increases sIL-2R levels. Clozapine 143-152 interleukin 6 Homo sapiens 82-86 7914751-0 1994 Interference of circulating azathioprine but not methotrexate or sulfasalazine with measurements of interleukin-6 bioactivity. Azathioprine 28-40 interleukin 6 Homo sapiens 100-113 33237143-8 2020 In addition, vinpocetine decreased the production of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-6 and IL-1beta. vinpocetine 13-24 interleukin 6 Homo sapiens 129-147 1761639-7 1991 Monocyte interleukin-6 downregulation by interleukin-4 is dose dependent and occurs whether Fc gamma RI cross-linking, muramyl dipeptide, indomethacin plus muramyl dipeptide, or interferon-gamma plus muramyl dipeptide is the interleukin-6 inducing stimulus. Indomethacin 138-150 interleukin 6 Homo sapiens 9-22 24440992-10 2014 In vitro, HU-308, a selective CB2R agonist, inhibited IL-1beta-induced proliferation of RA-FLS as well as IL-1beta-induced production of MMP-3, MMP-13 and IL-6 in RA-FLS in a dose-dependent manner. HU 308 10-16 interleukin 6 Homo sapiens 155-159 34088250-0 2022 NSAIDs/Nitazoxanide/Azithromycin Repurposed for COVID-19: Potential Mitigation of the Cytokine Storm Interleukin-6 Amplifier via Immunomodulatory Effects. nitazoxanide 7-19 interleukin 6 Homo sapiens 101-114 7906214-7 1994 In the CVI group elevated IL-6 levels were significantly associated to reduced numbers of CD4+ and CD19+ lymphocytes, elevated levels of neopterin and sCD8 antigen, and occurrence of splenomegaly and bronchiectasis. Neopterin 137-146 interleukin 6 Homo sapiens 26-30 1956868-3 1991 The incorporation of [14C]acetate into cholesterol in HSF was inhibited by AR 12463 and AR 12456, but not by trapidil. [14c]acetate 21-33 interleukin 6 Homo sapiens 54-57 7908651-1 1994 Porphyromonas gingivalis fimbriae as well as synthetic peptides that mimic the fimbrial subunit protein, which includes the amino acid sequence XLTXXLTXXNXX, induced high production of proinflammatory cytokines such as interleukin-1 beta, interleukin-6, interleukin-8, tumor necrosis factor-alpha in human peripheral blood monocyte/macrophage cultures. Peptides 55-63 interleukin 6 Homo sapiens 239-252 34988139-10 2021 In addition, SGDL granule + doxycycline effectively inhibited IBV replication and stopped IBV propagation from the trachea to the lung; modulated the mRNA expressions of IL-1beta, IL-6, TNF-alpha, and IFN-gamma; and extenuated the histopathology lesions in trachea and lung. Doxycycline 28-39 interleukin 6 Homo sapiens 180-184 8258685-4 1993 It is shown that LPS induced a 12- to 16-fold increase in IL-1 beta, IL-6, and TNF-alpha mRNA levels, and this was completely or more than 80% blocked by the protein tyrosine kinase specific inhibitors herbimycin A and genistein at the concentrations of 1.7 and 37 microM, respectively. herbimycin 202-214 interleukin 6 Homo sapiens 69-73 1956868-3 1991 The incorporation of [14C]acetate into cholesterol in HSF was inhibited by AR 12463 and AR 12456, but not by trapidil. Argon 75-77 interleukin 6 Homo sapiens 54-57 8258685-8 1993 In addition to cytokine mRNA levels, LPS-induced IL-6 protein synthesis and IL-6 bioactivity were also reduced to baseline levels by the PTK inhibitors herbimycin A and genistein. herbimycin 152-164 interleukin 6 Homo sapiens 49-53 8258685-8 1993 In addition to cytokine mRNA levels, LPS-induced IL-6 protein synthesis and IL-6 bioactivity were also reduced to baseline levels by the PTK inhibitors herbimycin A and genistein. herbimycin 152-164 interleukin 6 Homo sapiens 76-80 1956868-3 1991 The incorporation of [14C]acetate into cholesterol in HSF was inhibited by AR 12463 and AR 12456, but not by trapidil. Argon 88-90 interleukin 6 Homo sapiens 54-57 34281463-5 2021 Firstly, the decreased cell viability, elevated release of lactate dehydrogenase (LDH), and excessively released inflammatory factors tumor necrosis factor-alpha (TNF-alpha), interleukin- 6 (IL-6), and transforming growth factor-beta (TGF)-beta in bronchial BEAS-2B epithelial cells induced by stimulation with LPS were significantly reversed by the introduction of Telmisartan. Telmisartan 366-377 interleukin 6 Homo sapiens 175-189 34281463-5 2021 Firstly, the decreased cell viability, elevated release of lactate dehydrogenase (LDH), and excessively released inflammatory factors tumor necrosis factor-alpha (TNF-alpha), interleukin- 6 (IL-6), and transforming growth factor-beta (TGF)-beta in bronchial BEAS-2B epithelial cells induced by stimulation with LPS were significantly reversed by the introduction of Telmisartan. Telmisartan 366-377 interleukin 6 Homo sapiens 191-195 1715769-1 1990 The cDNA for human interleukin 6 (IL 6) was stably expressed at high levels in the three mammalian cell lines COS-7, PA317, and GH3 to yield IL 6 proteins of 25 to 27, 26, 22 to 24, and 23 kDa molecular mass. pa317 117-122 interleukin 6 Homo sapiens 19-32 1715769-1 1990 The cDNA for human interleukin 6 (IL 6) was stably expressed at high levels in the three mammalian cell lines COS-7, PA317, and GH3 to yield IL 6 proteins of 25 to 27, 26, 22 to 24, and 23 kDa molecular mass. pa317 117-122 interleukin 6 Homo sapiens 34-38 8219232-6 1993 The responsive cell line, CCL 185, secretes IL-6 after being incubated with rhIL-4. Cefaclor 26-29 interleukin 6 Homo sapiens 44-48 2252806-6 1990 IL-6 production was significantly reduced in the presence of Cuprophan (151 +/- 45 pg/ml), Hemophan (167 +/- 6 pg/ml), and polyacrylonitrile (108 +/- 33 pg/ml) when compared with polystyrole (724 +/- 34 pg/ml). polyacrylonitrile 123-140 interleukin 6 Homo sapiens 0-4 34678604-11 2021 Compound 11n was investigated for its ability to reduce Interleukin 6 and TNF-alpha. 1-[1'-(3-phenylacryloyl)spiro[1-benzofuran-3,4'-piperidin]-5-yl]methanamine 9-12 interleukin 6 Homo sapiens 56-69 1693429-5 1990 The IL-6-R was functional, as [3H]thymidine incorporation by AIDS-KS cells increased significantly after exposure to human recombinant IL-6 (hrIL-6) at greater than 10 units/ml. Potassium 66-68 interleukin 6 Homo sapiens 4-8 34666302-11 2021 Although the mean serum levels of interleukin-6 (IL-6) and glutathione changed significantly after 5 days in the PTX group (P = 0.03 and p = 0.04), ICU admission, intubation, and hospital stay did not differ between the two groups. Pentoxifylline 113-116 interleukin 6 Homo sapiens 34-47 34666302-11 2021 Although the mean serum levels of interleukin-6 (IL-6) and glutathione changed significantly after 5 days in the PTX group (P = 0.03 and p = 0.04), ICU admission, intubation, and hospital stay did not differ between the two groups. Pentoxifylline 113-116 interleukin 6 Homo sapiens 49-53 7764298-8 1993 To obtain mature hIL6, a sequence encoding the KEX2 cleavage-site (Lys-Arg) was inserted between glucoamylase and hIL6 sequences. Lys-Arg 67-74 interleukin 6 Homo sapiens 17-21 7764298-8 1993 To obtain mature hIL6, a sequence encoding the KEX2 cleavage-site (Lys-Arg) was inserted between glucoamylase and hIL6 sequences. Lys-Arg 67-74 interleukin 6 Homo sapiens 114-118 34666302-13 2021 Although PTX had a beneficial effect on IL-6 and showed an acceptable safety profile, it did not offer any clinical benefit for COVID-19 complications. Pentoxifylline 9-12 interleukin 6 Homo sapiens 40-44 1693429-11 1990 These results show that both IL-6 and IL-6-R are produced by AIDS-KS cells and that IL-6 is required for optimal AIDS-KS cell proliferation, and they suggest that IL-6 is an autocrine growth factor for AIDS-KS cells. Potassium 66-68 interleukin 6 Homo sapiens 29-33 34697842-3 2021 Results of ELISA experiments revealed that Garcinia kola extract (6.25, 12.5, and 25 mug/ml) and garcinoic acid (1.25, 2.5, and 5 muM) significantly reduced SARS-CoV-2 spike protein S1-induced secretion of TNFalpha, IL-6, IL-1beta, and IL-8 in PBMCs. garcinoic acid 97-111 interleukin 6 Homo sapiens 216-220 8227350-9 1993 In addition, IL-6 secretion by HCs was markedly augmented by TNF. Homocysteine 31-34 interleukin 6 Homo sapiens 13-17 1693429-11 1990 These results show that both IL-6 and IL-6-R are produced by AIDS-KS cells and that IL-6 is required for optimal AIDS-KS cell proliferation, and they suggest that IL-6 is an autocrine growth factor for AIDS-KS cells. Potassium 66-68 interleukin 6 Homo sapiens 38-42 1693429-11 1990 These results show that both IL-6 and IL-6-R are produced by AIDS-KS cells and that IL-6 is required for optimal AIDS-KS cell proliferation, and they suggest that IL-6 is an autocrine growth factor for AIDS-KS cells. Potassium 66-68 interleukin 6 Homo sapiens 38-42 2318977-2 1990 In this report, we provide evidence that human recombinant IL-6 increased platelet production in mice, as measured by both peripheral platelet levels and [75Se]selenomethionine (75SeM) incorporation into newly forming platelets. Selenomethionine 160-176 interleukin 6 Homo sapiens 59-63 8393676-6 1993 Both treatments induced decreases in IL-6 concentrations, but circulating AZA (or its metabolites) appears to interfere with the measurement of IL-6 bioactivity. Azathioprine 74-77 interleukin 6 Homo sapiens 144-148 8354288-4 1993 Prolonged incubation of 8-kDa 125I-IL-6 fragments with purified U937 plasma membranes, led to a complete loss of IL-6 activity related to the transformation of the 8-kDa forms into a higher-molecular-mass complex (16 kDa). 8-kda 24-29 interleukin 6 Homo sapiens 35-39 8354288-4 1993 Prolonged incubation of 8-kDa 125I-IL-6 fragments with purified U937 plasma membranes, led to a complete loss of IL-6 activity related to the transformation of the 8-kDa forms into a higher-molecular-mass complex (16 kDa). 8-kda 24-29 interleukin 6 Homo sapiens 113-117 8156173-2 1993 Exposure to beta-naphthoflavone and benz(a)anthracene resulted in a higher copy number of IL-1 alpha and IL-6 mRNA while lower level of IL-1 beta mRNA was detected in these cells. beta-Naphthoflavone 12-31 interleukin 6 Homo sapiens 105-109 34893117-10 2021 QPCR and Western blot showed that the arsenous acid, artesunate, and their combination treatment could inhibit the expression of mRNA and protein of cell proliferation-related factors interleukin-6 and vascular endothelial growth factor (P<0.05), inhibit apoptosis-related factor BCL-xl and promote the expression of mRNA and protein of Bax (P<0.05), and reduce the protein expression of p-PI3K and p-AKT in PI3K/AKT signaling pathway (P<0.05). Artesunate 53-63 interleukin 6 Homo sapiens 184-197 34959801-9 2021 Higher IL-6 concentrations at delivery were associated with the probability of delivering after 37 weeks, and higher-dose DHA supplementation increased the probability of greater increases in IL-6 concentrations between enrollment and delivery. Docosahexaenoic Acids 122-125 interleukin 6 Homo sapiens 192-196 2301010-0 1990 Evidence that glucocorticosteroids block expression of the human interleukin-6 gene by accessory cells. glucocorticosteroids 14-34 interleukin 6 Homo sapiens 65-78 34959801-10 2021 These data provide a proposed mechanistic explanation of how a higher dose of DHA during pregnancy provides immunomodulatory regulation in the initiation of parturition by influencing sRAGE and IL-6 levels, which may explain its ability to reduce the risk of preterm birth. Docosahexaenoic Acids 78-81 interleukin 6 Homo sapiens 194-198 34877026-12 2021 RESULTS: The concentration of IL-6 was significantly different at D3 post epigastric pain in both the MAP group and MSAP group with P = 0.001 and P = 0.013 respectively, in a multiplex assay. msap 116-120 interleukin 6 Homo sapiens 30-34 1394624-3 1992 We report here the in vitro activation of HSF by treating at 0 degrees C a HeLa cell-free system with the aldehyde 4-hydroxynonenal (HNE), a highly cytotoxic product of lipid peroxidation. 4-hydroxy-2-nonenal 115-131 interleukin 6 Homo sapiens 42-45 1394624-3 1992 We report here the in vitro activation of HSF by treating at 0 degrees C a HeLa cell-free system with the aldehyde 4-hydroxynonenal (HNE), a highly cytotoxic product of lipid peroxidation. 4-hydroxy-2-nonenal 133-136 interleukin 6 Homo sapiens 42-45 1324279-6 1992 The tyrosine kinase inhibitor herbimycin A blocked the induction of IL-6 by oncostatin M in HEC. herbimycin 30-42 interleukin 6 Homo sapiens 68-72 2301010-7 1990 We herein describe the effects of glucocorticosteroids on IL-6 synthesis. glucocorticosteroids 34-54 interleukin 6 Homo sapiens 58-62 34715784-5 2021 IL-6 and IL-8 as pro-inflammatory cytokines released during surgery, were lowered in mean 28-fold and 52-fold during the Catuvab procedure, respectively, whereas Catumaxomab antibody was detected in 8 of 16 of the final EC products at a considerable decreased and uncritical residual amount (37 ng in mean). catuvab 121-128 interleukin 6 Homo sapiens 0-4 2301010-8 1990 We provide evidence that glucocorticosteroids prevent IL-6 gene transcription in human peripheral blood mononuclear cells. glucocorticosteroids 25-45 interleukin 6 Homo sapiens 54-58 34746302-16 2021 The hub components possibly include quercetin, stigmasterol, kaempferol, and beta-sitosterol and act through pairing with hub targets, such as AKT1, VEGFA, and IL6, to regulate neuronal death, G protein-coupled amine receptor activity, reactive oxygen species metabolic process, membrane raft, MAPK signaling pathway, and cellular senescence for the treatment of PD. gamma-sitosterol 77-92 interleukin 6 Homo sapiens 160-163 1322305-11 1992 These results suggest a role for endogenous TNF and IL-6 in the triggering or aggravation of psoriasis in lithium-treated patients. Lithium 106-113 interleukin 6 Homo sapiens 52-56 29101672-9 2018 Similarly, an association between hydroxychloroquine consumption and low concentrations of IL-6 was found (p 0.005). Hydroxychloroquine 34-52 interleukin 6 Homo sapiens 91-95 34768873-8 2021 Graphene exposure (10 microg/mL) for 24 h significantly increased levels of pro-inflammatory cytokines IFNgamma, IL-8, IL-17, IL-6, IL-9, MIP-1alpha, and Eotaxin. Graphite 0-8 interleukin 6 Homo sapiens 126-130 34710437-8 2022 An IQR increase in salivary IL-6 concentration was associated with significantly increased FeNO by 28.8% (4.3%-53.4%). feno 91-95 interleukin 6 Homo sapiens 28-32 34681602-5 2021 Further, 2-IPMA inhibited the production of pro-inflammatory cytokines, including IL-6 and TNF-alpha, which were upregulated by PM2.5. 2-isopropylmalic acid 9-15 interleukin 6 Homo sapiens 82-86 1385797-0 1992 Differential effects of pentoxifylline on the production of tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) by monocytes and T cells. Pentoxifylline 24-38 interleukin 6 Homo sapiens 105-118 1385797-0 1992 Differential effects of pentoxifylline on the production of tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) by monocytes and T cells. Pentoxifylline 24-38 interleukin 6 Homo sapiens 120-124 1385797-2 1992 In this study, we found that PTX differentially regulates the production of TNF-alpha and interleukin-6 (IL-6). Pentoxifylline 29-32 interleukin 6 Homo sapiens 90-103 1385797-2 1992 In this study, we found that PTX differentially regulates the production of TNF-alpha and interleukin-6 (IL-6). Pentoxifylline 29-32 interleukin 6 Homo sapiens 105-109 1385797-3 1992 Indeed, PTX at high concentrations triggers the production of IL-6 but not of TNF-alpha by peripheral blood mononuclear cells (PBMC). Pentoxifylline 8-11 interleukin 6 Homo sapiens 62-66 1385797-4 1992 Further experiments indicated that monocytes are responsible for this PTX-induced IL-6 production. Pentoxifylline 70-73 interleukin 6 Homo sapiens 82-86 1385797-8 1992 In addition, the in vivo administration of PTX in transplant patients receiving the first dose of OKT3 allowed to decrease the systemic release of TNF-alpha but not of IL-6. Pentoxifylline 43-46 interleukin 6 Homo sapiens 168-172 1385797-10 1992 In this system, PTX was found to inhibit the secretion of both TNF-alpha and IL-6 by T cells. Pentoxifylline 16-19 interleukin 6 Homo sapiens 77-81 1385797-11 1992 We suggest that cAMP could be involved in these differential effects of PTX on production of TNF-alpha and of IL-6. Pentoxifylline 72-75 interleukin 6 Homo sapiens 110-114 34599734-7 2022 We calculated Pearson"s and partial correlations between sP-selectin, S100B and IL-6. sp-selectin 57-68 interleukin 6 Homo sapiens 80-84 34599734-8 2022 After controlling for potential confounders, sP-selectin positively correlated with S100B (r=0.31, p=0.004) and IL-6 (r=0.28, P=0.046). sp-selectin 45-56 interleukin 6 Homo sapiens 112-116 1294020-6 1992 IL-6 transcripts were nearly undetectable by blotting in keratinocytes grown in low-calcium serum-free medium, but low levels could be induced by treatment with 1.8 mM CaCl2. Calcium Chloride 168-173 interleukin 6 Homo sapiens 0-4 34710437-10 2022 We estimated that 13.2%-22.2% of the associations of PM2.5 exposure measured 1 day prior with FeNO and C-ACT scores were mediated by salivary IL-6. feno 94-98 interleukin 6 Homo sapiens 142-146 34250720-9 2021 What is more, hypaphorine attenuated the expression of inflammatory factors (IL-1beta, IL-6, TNF-alpha, and IL-18) and inactivated the p38/JNK signaling pathway through upregulating DUSP1 in a dose-dependent manner. lenticin 14-25 interleukin 6 Homo sapiens 87-91 34848238-3 2022 Besides, feruloylated AX (50-1000 mug/mL) markedly downregulated the mRNA expressions of NO, IL-1beta, TNF-alpha, IL-6, and IL-23a, and reduced the phosphorylation levels of p38, ERK, and JNK in M1. arabinoxylan 22-24 interleukin 6 Homo sapiens 114-118 34293392-13 2021 BA applications were more effective than BX on U-87MG cell line in terms of increasing MDA levels, SOD and CAT enzyme activities, and decreasing Interleukin-1alpha, Interleukin-6 and Tumor necrosis factor- alpha (TNF- alpha) levels. boric acid 0-2 interleukin 6 Homo sapiens 165-178 1340532-0 1992 Study of pentoxifylline induced modulation of TNF alpha and interleukin-6 secretion in healthy and septic patients by the use of an ex-vivo model on whole blood. Pentoxifylline 9-23 interleukin 6 Homo sapiens 60-73 1340532-1 1992 The aim of this work is to reinvestigate the pentoxifylline (PTX) action on TNF alpha and IL-6 production using a whole blood ex-vivo model. Pentoxifylline 45-59 interleukin 6 Homo sapiens 90-94 1340532-1 1992 The aim of this work is to reinvestigate the pentoxifylline (PTX) action on TNF alpha and IL-6 production using a whole blood ex-vivo model. Pentoxifylline 61-64 interleukin 6 Homo sapiens 90-94 1340532-4 1992 This inhibition is nearly complete for a PTX concentration of 10(-3) M. More surprisingly a suppressive activity of PTX on IL-6 secretion has been found both in controls and septic patients. Pentoxifylline 116-119 interleukin 6 Homo sapiens 123-127 34346720-4 2021 In their study, COVID-19 patients with indeterminate QuantiFERON-TB Gold Plus results trended toward decreased survival as well as increased serum IL-6 and IL-10 levels, though the differences were not statistically significant. quantiferon-tb gold 53-72 interleukin 6 Homo sapiens 147-151 34719371-5 2021 In particular, ALA is able to reduce inflammasome activity, the pro-inflammatory cytokine levels, such as TNF-alpha, IL-1beta, IL-6, IL-18 and IL-17, interferon (INF)-gamma as well as the production of Vascular and Intercellular cell adhesion protein (VCAM-1 and ICAM-1). Thioctic Acid 15-18 interleukin 6 Homo sapiens 127-131 34526064-8 2021 Before ketamine treatment, GM-CSF and IL-6 levels were higher in the pain group than in the non-pain and HC groups. Ketamine 7-15 interleukin 6 Homo sapiens 38-42 1933885-5 1991 The correlation between interleukin-6 and neopterin was weak but significant (Spearman"s rank correlation coefficient, 0.38; P = 0.019). Neopterin 42-51 interleukin 6 Homo sapiens 24-37 34976809-5 2021 Recent, some inhibitors of IL-6/STAT3 have been development, such as S31-201 or IL-6 neutralizing monoclonal antibody (IL-6 mAb), Madindoline A (Inhibits the dimerization of IL-6/IL-6R/gpl30 trimeric complexes), C188-9 and Curcumin (Inhibits STAT3 phosphorylation), etc. madindoline A 130-143 interleukin 6 Homo sapiens 174-178 1695009-5 1990 Up to 85% of the cells in a culture of human diploid dermal fibroblasts (HSF-55 cells) could be accumulated in G2 phase by placing cells presynchronized in early-S phase in medium containing Hoechst 33342 at 0.1 micrograms/ml for 10 hr. bisbenzimide ethoxide trihydrochloride 191-204 interleukin 6 Homo sapiens 73-76 34076332-6 2021 Furthermore ELISA and real time PCR reaction determined that brucine were down regulated inflammatory (TNF-alpha, NF-kB, IL-6 & COX-2) cell proliferation (Cyclin D1) and apoptotic marker Bax, caspase-3, PI3K (phosphoinosital 3 kinase), AKT, mTOR (mammalian target of rapamycin) and over expression Bcl-2, associated death promoter. brucine 61-68 interleukin 6 Homo sapiens 121-125 34090139-5 2021 IL-6 is critical for mediating hypophagia and weight loss effects of a GLP-1 analog, exendin-4, a clinically utilized drug. Exenatide 85-94 interleukin 6 Homo sapiens 0-4 34886812-12 2021 Simultaneously, acacetin reduced mesothelial cell-induced transcripts and production of pro-inflammatory cytokine IL-6 and IL-8 in ovarian cancer cells. acacetin 16-24 interleukin 6 Homo sapiens 114-118 34445685-4 2021 Celecoxib and GS alone or co-incubated with IL-1beta significantly reduced expression and release of cyclooxygenase (COX)-2, prostaglandin (PG)E2, IL-1beta, IL-6, tumor necrosis factor (TNF)-alpha, and MMPs, while it increased Col2a1, compared to baseline or IL-1beta. Celecoxib 0-9 interleukin 6 Homo sapiens 157-161 1968555-0 1990 Differential effect of oxpentifylline on tumour necrosis factor and interleukin-6 production. Pentoxifylline 23-37 interleukin 6 Homo sapiens 68-81 33773263-6 2021 Aryl thioether derivative 7f significantly reduced STAT3 phosphorylation (23%) and its nuclear localisation (16%) at 10 muM in tumorigenic LPCs, implicating the IL-6/JAK/STAT3 axis is central in the mode of action of our derivatives. aryl 0-4 interleukin 6 Homo sapiens 161-165 34725715-7 2021 RESULTS: Isoprenaline and formoterol (both beta2 agonists) induced IL-6, but not IL-8, release, which could be inhibited by ICI 118,551 (beta2 antagonist). Formoterol Fumarate 26-36 interleukin 6 Homo sapiens 67-71 34867458-15 2021 Conclusion: Our findings showed that combination EX + CR intervention effectively decreased CRP, IL-6, and TNF-alpha in overweight and obese adults with active lifestyles, but not with sedentary lifestyle behavior. Chromium 54-56 interleukin 6 Homo sapiens 97-101 33811859-9 2021 Furthermore, a partial antagonist of alpha7-nAChR, bupropion, rescued IL-6 but not GRO-alpha or I-309 production. Bupropion 51-60 interleukin 6 Homo sapiens 70-74 33808148-4 2021 Indeed, it was found in keratinocytes that carotenoids and polyphenols inhibit UVB-induced NFkappaB activity and release of cytokine IL-6. Polyphenols 59-70 interleukin 6 Homo sapiens 133-137 34421307-7 2021 Results: Arachidonyl-2"-chloroethylamide (ACEA) 10 nM, a persistent selective CB1 receptor agonist, promotes IL-6 gene expression in a time-dependent manner. arachidonyl-2-chloroethylamide 9-40 interleukin 6 Homo sapiens 109-113 34421307-7 2021 Results: Arachidonyl-2"-chloroethylamide (ACEA) 10 nM, a persistent selective CB1 receptor agonist, promotes IL-6 gene expression in a time-dependent manner. arachidonyl-2-chloroethylamide 42-46 interleukin 6 Homo sapiens 109-113 34421307-10 2021 Conclusion: For the first time, a unique link between ACEA and IL-6 up-regulation has been established; IL-6 up-regulation generated by ACEA is mediated in skeletal muscle through cannabinoid CB1 receptor activation. arachidonyl-2-chloroethylamide 54-58 interleukin 6 Homo sapiens 63-67 34421307-10 2021 Conclusion: For the first time, a unique link between ACEA and IL-6 up-regulation has been established; IL-6 up-regulation generated by ACEA is mediated in skeletal muscle through cannabinoid CB1 receptor activation. arachidonyl-2-chloroethylamide 136-140 interleukin 6 Homo sapiens 104-108 33779714-8 2021 At the same time, fasudil led to the reduction of IL-1beta, TNF-alpha, IL-6 and IL-8 mRNA levels in insulin-treated cells. fasudil 18-25 interleukin 6 Homo sapiens 71-75 34869089-7 2021 Meanwhile, the level of neutrophil, neutrophil/lymphocyte ratio (NLR), platelet count/lymphocyte ratio (PLR), mean platelet volume/lymphocyte ratio (MPVLR), C-reactive protein (CRP), lactic dehydrogenase (LDH), and interleukin (IL)-6 in the RMPP group was significantly higher (p < 0.01) than those in the NRMPP group. nrmpp 306-311 interleukin 6 Homo sapiens 215-233 34180293-6 2021 Rodent studies provided strong support for ketamine-induced decreases in pro-inflammatory cytokines, namely in interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha and indicated anti-inflammatory effects on TRP metabolism, including decreases in the enzyme indoleamine 2,3-dioxygenase (IDO). Ketamine 43-51 interleukin 6 Homo sapiens 135-139 34795863-6 2021 A subsequent functional assay using the MDA-MB-231 cell line demonstrated that the d-galactal-benzimidazole hybrid and the analogous galactoside derivative reduced the secretion of the proinflammatory cytokines interleukin-6 (IL-6) and IL-8 in a dose-dependent manner. Galactosides 133-144 interleukin 6 Homo sapiens 211-224 34361571-4 2021 Our results show that CM544 and FAB1020 are selective and decrease cytotoxicity, IL-6 secretion and LPS-stimulated monocyte migration. fab1020 32-39 interleukin 6 Homo sapiens 81-85 33774704-10 2021 Compared with healthy controls, clozapine-treated patients" BMI, blood glucose, and proinflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) increased significantly. Clozapine 32-41 interleukin 6 Homo sapiens 121-125 33774704-11 2021 In clozapine-treated patients, a higher clozapine daily dosage was associated with higher levels of the proinflammatory cytokines IL-1beta and IL-6, and a significant positive correlation was observed between blood glucose levels and the proinflammatory cytokines IL-6 and TNF-alpha. Clozapine 3-12 interleukin 6 Homo sapiens 143-147 33774704-11 2021 In clozapine-treated patients, a higher clozapine daily dosage was associated with higher levels of the proinflammatory cytokines IL-1beta and IL-6, and a significant positive correlation was observed between blood glucose levels and the proinflammatory cytokines IL-6 and TNF-alpha. Clozapine 3-12 interleukin 6 Homo sapiens 264-268 34795863-6 2021 A subsequent functional assay using the MDA-MB-231 cell line demonstrated that the d-galactal-benzimidazole hybrid and the analogous galactoside derivative reduced the secretion of the proinflammatory cytokines interleukin-6 (IL-6) and IL-8 in a dose-dependent manner. Galactosides 133-144 interleukin 6 Homo sapiens 226-230 33774704-11 2021 In clozapine-treated patients, a higher clozapine daily dosage was associated with higher levels of the proinflammatory cytokines IL-1beta and IL-6, and a significant positive correlation was observed between blood glucose levels and the proinflammatory cytokines IL-6 and TNF-alpha. Clozapine 40-49 interleukin 6 Homo sapiens 143-147 33774704-11 2021 In clozapine-treated patients, a higher clozapine daily dosage was associated with higher levels of the proinflammatory cytokines IL-1beta and IL-6, and a significant positive correlation was observed between blood glucose levels and the proinflammatory cytokines IL-6 and TNF-alpha. Clozapine 40-49 interleukin 6 Homo sapiens 264-268 34256854-14 2021 CONCLUSIONS: CD90low gaMSCs could increase FOXS1 expression in glioma cells by IL-6 secretion, thereby activating epithelial-mesenchymal transition and resistance to TMZ in glioma cells. Temozolomide 166-169 interleukin 6 Homo sapiens 79-83 34656268-4 2021 Irisin, IL-6 and TNF levels were measured in EDTA plasma through ELISA. Edetic Acid 45-49 interleukin 6 Homo sapiens 8-12 34143369-1 2022 This is a comprehensive systematic review and dose-response meta-analysis evaluating the effects of oral magnesium supplementation on inflammatory biomarkers including C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) among adults. Magnesium 105-114 interleukin 6 Homo sapiens 194-207 34143369-1 2022 This is a comprehensive systematic review and dose-response meta-analysis evaluating the effects of oral magnesium supplementation on inflammatory biomarkers including C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) among adults. Magnesium 105-114 interleukin 6 Homo sapiens 209-213 33806019-6 2021 We demonstrated that through interfering with NCOR2 suppressive activity, BQ favours the binding of ER to IL-6 promoter and the binding of NF-kB to IL-6 receptor (IL-6R) promoter, leading to the up-regulation of both IL-6 and IL-6R and thus the activation of STAT3. bulaquine 74-76 interleukin 6 Homo sapiens 106-110 33806019-6 2021 We demonstrated that through interfering with NCOR2 suppressive activity, BQ favours the binding of ER to IL-6 promoter and the binding of NF-kB to IL-6 receptor (IL-6R) promoter, leading to the up-regulation of both IL-6 and IL-6R and thus the activation of STAT3. bulaquine 74-76 interleukin 6 Homo sapiens 148-152 34772314-7 2021 CONCLUSION: Analysis of IL-6 levels in EDTA-treated plasma samples centrifuged within 1 hour and stored on ice can be performed within 90 minutes of short-term storage if the analytical method has a sensitivity in the range of 10 fg/mL. Edetic Acid 39-43 interleukin 6 Homo sapiens 24-28 33588937-10 2021 Stimulation by ThCM clearly changed the metabolic profile of both RASF and OASF by inducing a shift towards aerobic glycolysis with strongly increased lactate production together with a rise in IL-6 and MMP3 secretion. thcm 15-19 interleukin 6 Homo sapiens 194-198 34199278-4 2021 Here, we explored whether the mRNA expression of IL-1beta and IL-6, induced by the combination of DON and PCV2, would depend on the MAPK signaling pathway. deoxynivalenol 98-101 interleukin 6 Homo sapiens 62-66 34199278-7 2021 The results showed that PK-15 cells treated with DON or PCV2 induced the mRNA expression of IL-1beta and IL-6 in a time- and dose-dependent manner. deoxynivalenol 49-52 interleukin 6 Homo sapiens 105-109 34199278-8 2021 The combination of DON and PCV2 has an additive effect on inducing the mRNA expression of IL-1beta and IL-6. deoxynivalenol 19-22 interleukin 6 Homo sapiens 103-107 34754315-10 2021 Molecular docking results showed that quercetin, luteolin, kaempferol, tanshinone IIa, wogonin, naringenin, nobiletin, dihydrotanshinlactone, beta-sitosterol, and salviolone have good affinity with core target proteins IL6, PTGS2, MAPK1, MAPK3, and CGRP1. Salviolone 163-173 interleukin 6 Homo sapiens 219-222 34199278-9 2021 Additionally, both DON and PCV2 could induce the mRNA expression of IL-1beta and IL-6 via the ERK and the p38 MAPK signal pathways, while PCV2 could induce it via the JNK signal pathway. deoxynivalenol 19-22 interleukin 6 Homo sapiens 81-85 31213927-10 2019 Conclusion: High levels of serum IL-6, high levels of serum hepcidin and CD4 count <350 cells/microL were risk factors for ACD in HIV patients with cARV therapy. carv 151-155 interleukin 6 Homo sapiens 33-37 34590104-0 2021 Photoelectrochemical immunoassay of interleukin-6 based on covalent reaction-triggered photocurrent polarity switching of ZnO@fullerenol. fullerenol 126-136 interleukin 6 Homo sapiens 36-49 26335632-8 2015 IL-6 and IFNgamma were downregulated in HMGECs treated for 72 h with DHA and EPA. Docosahexaenoic Acids 69-72 interleukin 6 Homo sapiens 0-4 26335632-9 2015 In general, TNFalpha, IFNgamma and IL-6 levels were decreased after 72 h compared to 24 h in serum containing medium with or without DHA or EPA. Docosahexaenoic Acids 133-136 interleukin 6 Homo sapiens 35-39 34944461-6 2021 RESULTS: NTZ exerts an inhibitory effect on the cell proliferation of T lymphocytes stimulated with anti-CD3 and anti-CD28 antibodies without modifying cell viability, and significant decreases in the supernatant concentrations of interleukin (IL)-1beta, IL-2, IL-6, IL-10, and IL-12. nitazoxanide 9-12 interleukin 6 Homo sapiens 261-265 34149863-13 2021 SCDP key active ingredients are mainly quercetin, wogonin, baicalein, acacetin, oroxylin A, and beta-sitosterol, which function mainly by regulating targets, such as PTGS2, CASP3, TP53, IL-6, TNF, and AKT1, and are associated with multiple signaling pathways as pathways in cancer, PI3K-Akt signaling pathway, apoptosis, IL-17 signaling pathways. gamma-sitosterol 96-111 interleukin 6 Homo sapiens 186-190 34078370-0 2021 Cryptolepine inhibits hepatocellular carcinoma growth through inhibiting interleukin-6/STAT3 signalling. cryptolepine 0-12 interleukin 6 Homo sapiens 73-86 34078370-3 2021 This study aimed to establish the effect of cryptolepine, which is the main bioactive alkaloid in the medicinal plant Cryptolepis sanguinolenta, on the IL-6/STAT3 signalling pathway. cryptolepine 44-56 interleukin 6 Homo sapiens 152-156 34078370-4 2021 METHODS: First, the effect of cryptolepine on the IL-6/STAT3 pathway in human hepatoma cells (HepG2 cells) was screened using the Cignal Finder Multi-Pathway Reporter Array. cryptolepine 30-42 interleukin 6 Homo sapiens 50-54 34078370-5 2021 Next, to confirm the effect of cryptolepine on the IL-6/STAT3 signalling pathway, the pathway was activated using 200 ng/mL IL-6 in the presence of 0.5-2 muM cryptolepine. cryptolepine 31-43 interleukin 6 Homo sapiens 51-55 34704081-4 2021 A serial mediation model utilizing a large epidemiologic dataset (final N = 527) supported our central hypothesis that the direct effect of childhood maltreatment on IL-6 was fully serially statistically mediated by SA symptoms and low PA (but not high negative affect). Protactinium 236-238 interleukin 6 Homo sapiens 166-170 34078370-7 2021 RESULTS: Cryptolepine downregulated 12 signalling pathways including the IL-6/STAT3 signalling pathway and upregulated 17 signalling pathways. cryptolepine 9-21 interleukin 6 Homo sapiens 73-77 34078370-8 2021 Cryptolepine, in the presence of IL-6, decreased the levels of p-STAT3 and IL-23 in a dose-dependent fashion. cryptolepine 0-12 interleukin 6 Homo sapiens 33-37 34078370-9 2021 CONCLUSION: Our results demonstrated that cryptolepine inhibits the IL-6/STAT3 signalling pathway, and therefore cryptolepine-based remedies such as Cryptolepis sanguinolenta could potentially be used as an effective immunotherapeutic agent for hepatocellular carcinoma and other cancers. cryptolepine 42-54 interleukin 6 Homo sapiens 68-72 34078370-9 2021 CONCLUSION: Our results demonstrated that cryptolepine inhibits the IL-6/STAT3 signalling pathway, and therefore cryptolepine-based remedies such as Cryptolepis sanguinolenta could potentially be used as an effective immunotherapeutic agent for hepatocellular carcinoma and other cancers. cryptolepine 113-125 interleukin 6 Homo sapiens 68-72 34704172-6 2021 ROCK is activated in the synovial of rheumatoid arthritis patients, while the blocking of ROCK with fasudil could also decrease IL-6, TNF-alpha, and IL-1. fasudil 100-107 interleukin 6 Homo sapiens 128-132 34877356-12 2021 The decreased degree of IL-6 and TNF-alpha in CTG was higher than that in RTG (p < 0.05). ezogabine 74-77 interleukin 6 Homo sapiens 24-28 34704081-6 2021 Trait mindfulness moderated the association between low PA and IL-6, to the exclusion of any paths related to negative affect. Protactinium 56-58 interleukin 6 Homo sapiens 63-67 34704081-8 2021 Overall, we conclude that childhood maltreatment and SA symptoms have a significant influence on IL-6, albeit indirectly via low PA, and the influence of PA on IL-6 may be uniquely susceptible to influence by individual differences in mindfulness. Protactinium 129-131 interleukin 6 Homo sapiens 97-101 34853573-10 2021 Olmesartan significantly decreased ASDAS, BASDAI, BASFI, ESR, CRP, IL-6, TNF-alpha, and SCORE as compared with placebo. olmesartan 0-10 interleukin 6 Homo sapiens 67-71 34704081-8 2021 Overall, we conclude that childhood maltreatment and SA symptoms have a significant influence on IL-6, albeit indirectly via low PA, and the influence of PA on IL-6 may be uniquely susceptible to influence by individual differences in mindfulness. Protactinium 154-156 interleukin 6 Homo sapiens 160-164 34148304-6 2021 Additionally, ginkgetin suppressed HG-evoked transcript and release of inflammatory cytokine TNF-alpha, IL-1beta and IL-6. ginkgetin 14-23 interleukin 6 Homo sapiens 117-121 35504209-2 2022 In this study, a series of benzobis(imidazole) derivatives were identified as STAT3 signal inhibitors, among which compound 24 showed significant inhibition of IL-6 induced JAK/STAT3 signalling pathway activation. imidazole 36-45 interleukin 6 Homo sapiens 160-164 34817840-5 2022 In addition, CCP transfusion caused a significant reduction in the overall inflammatory status of the patients regardless of the severity of disease or outcome, as evidenced by decreasing C-reactive protein, IL6 and ferritin levels. ccp 13-16 interleukin 6 Homo sapiens 208-211 34817840-7 2022 We also observed that IL-6 may be a suitable laboratory parameter for patient selection and monitoring of CCP therapy effectiveness. ccp 106-109 interleukin 6 Homo sapiens 22-26 34630611-8 2021 After treatment, the levels of NSE, MBP, TNF-alpha, and IL-6 in the two groups decreased, and the levels of BDNF increased, and the LEV group changed significantly compared with the VPA group (P < 0.05). Valproic Acid 182-185 interleukin 6 Homo sapiens 56-60 34830070-13 2021 Moreover, clofazimine significantly increased the production of IL-6 in human macrophages that were stimulated with iH37Rv-Mtb. Clofazimine 10-21 interleukin 6 Homo sapiens 64-68 35427919-0 2022 Peripheral lower triiodothyronine levels related to interleukin-6 in patients with first-episode schizophrenia. Triiodothyronine 17-33 interleukin 6 Homo sapiens 52-65 34286801-4 2021 In macrophages, melanoidins significantly suppress the mRNA expression of interleukin (Il)-6, Il-1beta and tumor necrosis factor alpha (Tnf-alpha) with a concomitant inhibitory effect on IL-1beta, IL-6 and TNFalpha secretion, which are increased by ethanol. melanoidin polymers 16-27 interleukin 6 Homo sapiens 74-92 34374416-8 2021 This 9-ARG signature was also significantly associated with the enrichment of cancer hallmarks, including angiogenesis, IL6-KJAK-STAT3 signalling, reactive oxygen species pathway and oxidative phosphorylation. 9-arg 5-10 interleukin 6 Homo sapiens 120-123 35624084-8 2022 As a potential mechanism, we suggest that protoporphyrin IX and/or protoheme from Prevotella participates in hepatic injury, and that endogenous hydrogen sulfide increases serum IL-6 level in P patients. Hydrogen Sulfide 145-161 interleukin 6 Homo sapiens 178-182 35570279-5 2022 RESULTS: HRV-Cs infect and propagate in fully differentiated HBE cells and significantly increase the secretion of IFN-lambda1, CCL5, IP10, IL-6, IL-8, and MCP-1. hrv-cs 9-15 interleukin 6 Homo sapiens 140-144 34871221-7 2021 All outcomes were measured after 10-day treatment.After treatment, patients who received AC exerted better improvements in erythrocyte sedimentation rate (P < .01), C-reactive protein (P < .01), serum lactate dehydrogenase (P < .01), interleukin 6 (P < .01), fever clearance time (P < .01), time of cough disappearance (P < .01), time of rale disappearance (P < .01), and time of signs disappeared by X-ray (P < .01), than those in patients who received EAS. Charcoal 89-91 interleukin 6 Homo sapiens 234-247 34901384-0 2021 Ultrasensitive Detection of Dopamine, IL-6 and SARS-CoV-2 Proteins on Crumpled Graphene FET Biosensor. Graphite 79-87 interleukin 6 Homo sapiens 38-42 35532870-8 2022 CDC25A overexpression or IL-6 treatment could attenuate inhibiting impact of miR-99a-5p overexpression on epithelial-mesenchymal transition (EMT). mir-99a 77-84 interleukin 6 Homo sapiens 25-29 34445405-3 2021 The FDA-approved drug Bazedoxifene is a novel inhibitor of protein-protein interactions between IL-6 and GP130. bazedoxifene 22-34 interleukin 6 Homo sapiens 96-100 35600853-8 2022 PN-G also reduced the levels of interleukin-6 (IL-6) and interleukin-1 beta (IL-1beta), in a dose dependent manner, in inflamed human macrophagic THP-1 cells, thereby, reaffirming its anti-inflammatory property at cytosafe concentrations. pn-g 0-4 interleukin 6 Homo sapiens 32-45 35600853-8 2022 PN-G also reduced the levels of interleukin-6 (IL-6) and interleukin-1 beta (IL-1beta), in a dose dependent manner, in inflamed human macrophagic THP-1 cells, thereby, reaffirming its anti-inflammatory property at cytosafe concentrations. pn-g 0-4 interleukin 6 Homo sapiens 47-51 34628222-4 2021 In particular, corniculatolide B significantly inhibited the protein expression of COX-2 and the mRNA expressions of TNF-alpha, IL-1beta and IL-6 by inhibiting of NF-kappaB signaling in intestinal epithelial cells induced by lipopolysaccharide treatment. corniculatolide b 15-32 interleukin 6 Homo sapiens 141-145 34241784-4 2021 Characellide A induces a concentration- and time-dependent CXCL8, IL-6 and TNF-alpha release from PBMC. characellide a 0-14 interleukin 6 Homo sapiens 66-70 34499917-8 2021 Hcy exposure increased CBS protein expression, hydrogen sulfide levels and pro-inflammatory cytokines, modulating CBS by silencing did not alter H2S levels, but inhibition of CSE with PAG inhibited H2S production and decreased cytokine (IL-6 and IL-8) levels. Homocysteine 0-3 interleukin 6 Homo sapiens 237-241 35506423-6 2022 Secondly, Everolimus significantly reduced the expressions of the pro-inflammatory cytokines interleukin (IL)-6, tumor necrosis factor-alpha (TNF-alpha), and IL-8. Everolimus 10-20 interleukin 6 Homo sapiens 93-111 35529923-5 2022 Gandakang tablets plus methylprednisolone resulted in significantly lower SLEDAI scores and lower levels of IgG, IgM, IgA, tumor necrosis factor-alpha (TNF-alpha), interleukin-4 (IL-4), and interleukin-6 (IL-6) versus single medication of methylprednisolone (P < 0.05). Methylprednisolone 23-41 interleukin 6 Homo sapiens 190-203 35529923-5 2022 Gandakang tablets plus methylprednisolone resulted in significantly lower SLEDAI scores and lower levels of IgG, IgM, IgA, tumor necrosis factor-alpha (TNF-alpha), interleukin-4 (IL-4), and interleukin-6 (IL-6) versus single medication of methylprednisolone (P < 0.05). Methylprednisolone 23-41 interleukin 6 Homo sapiens 205-209 34790130-0 2021 Beta-Lapachone Attenuates BMSC-Mediated Neuroblastoma Malignant Transformation by Inhibiting Gal-3/Gal-3BP/IL6 Axis. beta-lapachone 0-14 interleukin 6 Homo sapiens 107-110 34369925-6 2021 Similar percent drops in metabolic activity of the iHCEC and pHCEC occurred after exposure to BAK, H2O2, or SDS, and the most significant changes in cytokine release occurred for IL-6 and IL-8. Benzalkonium Compounds 94-97 interleukin 6 Homo sapiens 179-183 34790130-4 2021 Beta-Lapachone (ARQ-501, LPC), an ortho-naphthoquinone natural product, significantly prevented the iBMSC-induced malignant transformation effect on NB cells through suppressing the expression and secretion of IL6 from iBMSC in vitro and in vivo. beta-lapachone 0-14 interleukin 6 Homo sapiens 210-213 34390919-10 2021 The peptide MTADV (but not scrambled TMVAD) significantly inhibited the release of pro-inflammatory cytokines IL-6 and IL-1beta from SAA-activated human fibroblasts, THP-1 monocytes and peripheral blood mononuclear cells. mtadv 12-17 interleukin 6 Homo sapiens 110-114 35484857-4 2022 HPS-50 significantly decreased the levels of ALT, AST, MPO, and MDA, increased the activities of SOD, CAT, and GSH, and suppressed the LPS/D-GalN-triggered production of TNF-alpha, IL-1beta, and IL-6 (p < .05). Galactosamine 139-145 interleukin 6 Homo sapiens 195-199 34201934-7 2021 It was found that treatment with DHM suppressed the levels of inflammatory cytokines TNF-alpha and IL-6 in DNP-IgE-sensitized KU812 cells. dihydromyricetin 33-36 interleukin 6 Homo sapiens 99-103 35385549-10 2022 Based on the stability of the complexes, the high interactions rate of each ligand with the key residues of IL-6/IL-6Ralpha, and the low binding free energy calculation, two compounds ZINC83804241 and ZINC02997430, were identified as the most potential IL-6 inhibitor candidates. zinc02997430 201-213 interleukin 6 Homo sapiens 108-112 35385549-10 2022 Based on the stability of the complexes, the high interactions rate of each ligand with the key residues of IL-6/IL-6Ralpha, and the low binding free energy calculation, two compounds ZINC83804241 and ZINC02997430, were identified as the most potential IL-6 inhibitor candidates. zinc02997430 201-213 interleukin 6 Homo sapiens 253-257 35212163-3 2022 We initially found that the glycolytic inhibitor 2-deoxy-d-glucose (2-DG), a simple monosaccharide, attenuated cellular responses to IL-6 by inhibiting N-linked glycosylation of the IL-6 receptor gp130. Deoxyglucose 68-72 interleukin 6 Homo sapiens 182-186 34771643-4 2021 Tris DBA decreased cell viability, increased apoptosis, and inhibited IL-6 induced/constitutive activation of STAT3, JAK1, JAK2, and Src in HCC and MM cells. Tromethamine 0-4 interleukin 6 Homo sapiens 70-74 34682144-10 2021 RSS significantly correlated with TA percent CD4+IL-6+ cells. RSS 0-3 interleukin 6 Homo sapiens 49-53 34500843-9 2021 Moreover, 2-IPMA inhibited proinflammatory cytokine production, i.e., IL-6 and TNF-alpha, induced by PM2.5 in RPE cells. 2-isopropylmalic acid 10-16 interleukin 6 Homo sapiens 70-74 35104780-0 2022 The DPA-derivative 11S, 17S-dihydroxy 7,9,13,15,19 (Z,E,Z,E,Z)-docosapentaenoic acid inhibits IL-6 production by inhibiting ROS production and ERK/NF-kappaB pathway in keratinocytes HaCaT stimulated with a fine dust PM10. docosapentaenoic acid 4-7 interleukin 6 Homo sapiens 94-98 34350239-11 2021 Results: We observed decreased cell viability, increased apoptosis, and increased inflammatory factors such as IL-1beta, IL-6, and TNF-alpha in the MPP+ induced PD model. mangion-purified polysaccharide (Candida albicans) 148-151 interleukin 6 Homo sapiens 121-125 35104780-5 2022 We demonstrated that DoPE suppressed PM10-induced expressions of IL-6 mRNA and protein in human HaCaT keratinocytes. docosapentaenoic acid 21-25 interleukin 6 Homo sapiens 65-69 35197546-0 2022 Ibrutinib reverses IL-6-induced osimertinib resistance through inhibition of Laminin alpha5/FAK signaling. ibrutinib 0-9 interleukin 6 Homo sapiens 19-23 35197546-7 2022 Next, using a large-scale compound screening, we identify ibrutinib as a potent inhibitor of IL-6 and Laminin alpha5/FAK signaling, which shows synergy with osimertinib in osimertinib-resistant cells with high IL-6 levels, but not in those with low IL-6 levels. ibrutinib 58-67 interleukin 6 Homo sapiens 93-97 35197546-7 2022 Next, using a large-scale compound screening, we identify ibrutinib as a potent inhibitor of IL-6 and Laminin alpha5/FAK signaling, which shows synergy with osimertinib in osimertinib-resistant cells with high IL-6 levels, but not in those with low IL-6 levels. ibrutinib 58-67 interleukin 6 Homo sapiens 210-214 35197546-7 2022 Next, using a large-scale compound screening, we identify ibrutinib as a potent inhibitor of IL-6 and Laminin alpha5/FAK signaling, which shows synergy with osimertinib in osimertinib-resistant cells with high IL-6 levels, but not in those with low IL-6 levels. ibrutinib 58-67 interleukin 6 Homo sapiens 249-253 34483461-2 2021 The objective of our study is to unravel the binding mechanism of the Food and Drug Administration (FDA)-approved dexamethasone (Dex) and boceprevir (Boc) drugs with selected COVID-19 protein targets SARS-CoV-2 spike protein C-terminal domain (spike-CTD), main protease (Mpro), and interleukin-6 (IL-6). N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide 138-148 interleukin 6 Homo sapiens 282-295 34483461-2 2021 The objective of our study is to unravel the binding mechanism of the Food and Drug Administration (FDA)-approved dexamethasone (Dex) and boceprevir (Boc) drugs with selected COVID-19 protein targets SARS-CoV-2 spike protein C-terminal domain (spike-CTD), main protease (Mpro), and interleukin-6 (IL-6). N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide 138-148 interleukin 6 Homo sapiens 297-301 34483461-2 2021 The objective of our study is to unravel the binding mechanism of the Food and Drug Administration (FDA)-approved dexamethasone (Dex) and boceprevir (Boc) drugs with selected COVID-19 protein targets SARS-CoV-2 spike protein C-terminal domain (spike-CTD), main protease (Mpro), and interleukin-6 (IL-6). N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide 150-153 interleukin 6 Homo sapiens 282-295 34483461-2 2021 The objective of our study is to unravel the binding mechanism of the Food and Drug Administration (FDA)-approved dexamethasone (Dex) and boceprevir (Boc) drugs with selected COVID-19 protein targets SARS-CoV-2 spike protein C-terminal domain (spike-CTD), main protease (Mpro), and interleukin-6 (IL-6). N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide 150-153 interleukin 6 Homo sapiens 297-301 34466023-9 2021 The concentrations of IL-6, procalcitonin (PCT), FBG, and tacrolimus (TAC) in the first month postoperatively were significantly higher in the NODM group than in the NO-NODM group. nodm 143-147 interleukin 6 Homo sapiens 22-26 35197546-9 2022 Taken together, we conclude that Laminin alpha5/FAK signaling is responsible for IL-6-induced osimertinib resistance, which could be reversed by combination of ibrutinib and osimertinib. ibrutinib 160-169 interleukin 6 Homo sapiens 81-85 35130850-9 2022 After treatment, the CG exhibited decreased levels of IL-1(ng/mL), IL-6 (ng/mL), and TNF-alpha (ng/mL) compared with the MG. Spearman correlation analysis revealed that IL-1, IL-6, and TNF-alpha were negatively correlated with clinical efficacy. cg 21-23 interleukin 6 Homo sapiens 67-71 35130850-9 2022 After treatment, the CG exhibited decreased levels of IL-1(ng/mL), IL-6 (ng/mL), and TNF-alpha (ng/mL) compared with the MG. Spearman correlation analysis revealed that IL-1, IL-6, and TNF-alpha were negatively correlated with clinical efficacy. cg 21-23 interleukin 6 Homo sapiens 175-179 34467691-5 2021 The results revealed that the main compounds of Euodiae Fructus, such as berberine and rutaecarpine, participated in the biological processes(such as neurotransmitter receptor activity) by regulating C-reactive protein(CRP), estrogen receptor 1(ESR1), 5-hydroxytryptamine(5-HT) receptor, and interleukin-6(IL-6) to exert sedative, anxiolytic, and antidepressant effects. rutecarpine 87-99 interleukin 6 Homo sapiens 306-310 34099595-7 2022 LUA treatment dramatically reduced LPS-stimulated reactive oxygen species (ROS) and mRNA levels of pro-inflammatory mediators such as IL-1beta, IL-6, IL-8 and IFN-beta. lua 0-3 interleukin 6 Homo sapiens 144-148 35057010-7 2022 Luteolin and rutin inhibit NFkappaB activation, reducing IL-6 production. Rutin 13-18 interleukin 6 Homo sapiens 57-61 34378863-0 2022 Efficacy of High versus Conventional Dose of Ergocalciferol Supplementation on Serum 25-Hydroxyvitamin D and Interleukin-6 Levels among Hemodialysis Patients with Vitamin D Deficiency: a Multicenter, Randomized, Controlled Study. Ergocalciferols 45-59 interleukin 6 Homo sapiens 109-122 34334139-5 2021 These actions of sodium, potassium and magnesium and other minerals, trace elements and vitamins are likely to be secondary to their action on pro-inflammatory cytokines IL-6, TNF-alpha and IL-17 and metabolism of essential fatty acids that may account for their involvement in the pathobiology of insulin resistance, T2DM, HTN and autoimmune diseases. Magnesium 39-48 interleukin 6 Homo sapiens 170-174 34349610-5 2021 Cerulein, a cholecystokinin analog, induces calcium (Ca2+) overload, oxidative stress, and IL-6 expression in pancreatic acinar cells, which are hallmarks of acute pancreatitis. Cholecystokinin 12-27 interleukin 6 Homo sapiens 91-95 35347345-6 2022 For M1 macrophage polarization, sodium butyrate significantly intensified the antiinflammatory function of PSLs, inhibiting LPS-induced proinflammatory genes expression, cytokines and enzyme release (tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, and inducible nitric oxide synthase), as well as CD86 (M1 marker) expression. Butyric Acid 32-47 interleukin 6 Homo sapiens 253-257 34285296-6 2021 Inflammatory markers induced by TNF-alpha, including IL-1, IL-6, MCP-1 and RANTES, were also suppressed following administration of clodronate. Clodronic Acid 132-142 interleukin 6 Homo sapiens 59-63 34110682-3 2021 Here, an intelligent aptameric dual channel graphene-TWEEN 80 field effect transistor (DGTFET) biosensing device for on-site detection of IFN-gamma, TNF-alpha, and IL-6 within 7 min with limits of detection (LODs) of 476 x 10-15 , 608 x 10-15 , or 611 x 10-15 m respectively in biofluids is presented. Graphite 44-52 interleukin 6 Homo sapiens 164-168 34979511-12 2022 miR-3622b-5p overexpression increased chondrocyte proliferation, inhibited chondrocyte apoptosis, and enhanced the expression of IL-6 and TNF-alpha in chondrocytes. mir-3622b-5p 0-12 interleukin 6 Homo sapiens 129-133 35521772-11 2022 Moreover, oleic acid stimulation upregulated the transcription levels of IL-6 and IL-8 via ERK1/2 signaling pathways in KGN cells. Oleic Acid 10-20 interleukin 6 Homo sapiens 73-77 35563819-10 2022 The infiltration of T cells into the epidermis was reduced when ALA was added to the culture medium, and significant decreases in the levels of inflammatory cytokines and chemokines such as CXCL1, interleukin-6 (IL-6) and interleukin-8 (IL-8) were consequently measured in psoriatic substitutes supplemented with this n-3 PUFA. alpha-Linolenic Acid 64-67 interleukin 6 Homo sapiens 197-210 34204056-3 2021 The ellagitannins (1 and 2) were evaluated on its inhibitory activities of the enzyme 5alpha-reductase and tumor necrosis factor (TNF)-alpha, its interleukin (IL)-1beta, IL-6, and IL-8 production, and its anti-proliferation and apoptosis induction in prostate cells that show hypertrophy (RWPE-1 cell). Hydrolyzable Tannins 4-17 interleukin 6 Homo sapiens 170-174 34090451-2 2021 The aim of this study was to investigate the effects of betaine supplementation on tumor necrosis factor alpha (TNF-alpha), interleukins-1 beta (IL-1beta), - 6 (IL-6) and the complete blood cell (CBC) count in professional youth soccer players during a competitive season. Betaine 56-63 interleukin 6 Homo sapiens 161-165 35563819-10 2022 The infiltration of T cells into the epidermis was reduced when ALA was added to the culture medium, and significant decreases in the levels of inflammatory cytokines and chemokines such as CXCL1, interleukin-6 (IL-6) and interleukin-8 (IL-8) were consequently measured in psoriatic substitutes supplemented with this n-3 PUFA. alpha-Linolenic Acid 64-67 interleukin 6 Homo sapiens 212-216 35471556-3 2022 MV treatment also decreased the production of pro-inflammatory cytokines, such as interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha in C6 glial cells stimulated by LPS/IFN-gamma. mv 0-2 interleukin 6 Homo sapiens 112-116 34075738-7 2021 Our data confirmed that Ononin could alleviate TNF-alpha-induced RA-FLS and MH7A cells viability, increase cell apoptosis, decrease the production of pro-inflammatory cytokines like interleukin-1beta (IL-1beta) and interleukin 6 (IL-6), and further inhibit the abnormal activation of NF-kappaB and MAPK pathways. calycosin-7-O-beta-D-glucoside 24-30 interleukin 6 Homo sapiens 215-228 34075738-7 2021 Our data confirmed that Ononin could alleviate TNF-alpha-induced RA-FLS and MH7A cells viability, increase cell apoptosis, decrease the production of pro-inflammatory cytokines like interleukin-1beta (IL-1beta) and interleukin 6 (IL-6), and further inhibit the abnormal activation of NF-kappaB and MAPK pathways. calycosin-7-O-beta-D-glucoside 24-30 interleukin 6 Homo sapiens 230-234 34136506-8 2021 For serum IL-6 levels, the SDAI (R 2 = 0.208) followed by the HUPI model (R 2 = 0.205). sdai 27-31 interleukin 6 Homo sapiens 10-14 35272139-9 2022 BromAc acted on IL-6, demonstrating a reduction in G-CSF and VEGF-D at concentrations of 125 and 250 microg. bromac 0-6 interleukin 6 Homo sapiens 17-21 35453017-10 2022 (3) based on canonical correlation analysis, the exposure to p-cymene, benzene, and styrene in PM2.5 was most likely associated with the toxicity effects (CAT, IL-6, and TNF-alpha), which in turn caused the observed toxicity. Benzene 71-78 interleukin 6 Homo sapiens 160-164 35351591-7 2022 Furthermore, DON increased NNMT to reduce pro-inflammatory cytokines, including interleukin (IL)-1beta, IL-11 and IL-6, and thus increased IGF-1 and cell viability, alleviating the cell growth inhibition induced by DON. deoxynivalenol 13-16 interleukin 6 Homo sapiens 114-118 35365723-6 2022 IL-8, IL-6 and TNF-alpha secretion was induced by LPA in MDA-MB-468 cells. lysophosphatidic acid 50-53 interleukin 6 Homo sapiens 6-10 35624727-6 2022 In a dose-dependent manner, concomitant administration of kinetin with cisplatin significantly restored testicular oxidative stress parameters, corrected the distorted sperm quality parameters and histopathological changes, enhanced levels of serum testosterone and testicular StAR protein expression, as well as reduced the up-regulation of testicular TNF-alpha, IL-1beta, Il-6, and caspase-3, caused by cisplatin. Kinetin 58-65 interleukin 6 Homo sapiens 374-378 35182801-9 2022 The mediating effect of IL-6 and generalized inflammation factor between MEHP exposure and depressive symptoms were 15.96% (95%CI=0.0288-0.1971) and 14.25% (95%CI = 0.0167-0.1899). mono-(2-ethylhexyl)phthalate 73-77 interleukin 6 Homo sapiens 24-28 35388303-9 2022 The key active ingredients were mainly quercetin, beta-estradiol, berberine, wogonin, and beta-sitosterol, and the key targets were also identified, including IL-6, AKT1, MAPK3, PIK3CA, and TNF. gamma-sitosterol 90-105 interleukin 6 Homo sapiens 159-163 35093493-8 2022 CTQ total and emotional abuse scores were significantly correlated with smaller IL-6 diurnal variation as indexed by lower standard deviation across the measurement times (p=0.024 and p=0.008, respectively). cysteine tryptophylquinone 0-3 interleukin 6 Homo sapiens 80-84 35184641-7 2022 The TNF-alpha-induced production of interleukin (IL)-6 and IL-8 in HC-A cells were mitigated by butorphanol tartrate. Butorphanol 96-116 interleukin 6 Homo sapiens 36-54 35104780-8 2022 Collectively, our results demonstrated that DoPE inhibited IL-6 expression by reducing ROS generation, suppressing ERK phosphorylation, and inhibiting translocation of NF-kB p65 and NF-kB activity in PM10-stimulated HaCaT cells, suggesting that DoPE can be useful for the resolution of the inflammation caused by IL-6. docosapentaenoic acid 44-48 interleukin 6 Homo sapiens 59-63 35104780-8 2022 Collectively, our results demonstrated that DoPE inhibited IL-6 expression by reducing ROS generation, suppressing ERK phosphorylation, and inhibiting translocation of NF-kB p65 and NF-kB activity in PM10-stimulated HaCaT cells, suggesting that DoPE can be useful for the resolution of the inflammation caused by IL-6. docosapentaenoic acid 44-48 interleukin 6 Homo sapiens 313-317 35093493-9 2022 Individuals with emotional abuse, as defined by a cut-off score of CTQ, showed flatter IL-6 rhythm than those without (p=0.031). cysteine tryptophylquinone 67-70 interleukin 6 Homo sapiens 87-91 35014680-9 2022 Notably, the effects of TGM2 siRNAs on T-cell lymphoma cells were attenuated by IL-6 and accelerated by IL-6/JAK/STAT3 inhibitor AG490. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 129-134 interleukin 6 Homo sapiens 104-108 35090964-3 2022 Moreover, apoptosis and inflammatory response were promoted after the co-exposure of ZEA and DON, indicated by the increased expression of BAX, Caspase-3, IL-1beta and IL-6 genes. deoxynivalenol 93-96 interleukin 6 Homo sapiens 168-172 35090964-3 2022 Moreover, apoptosis and inflammatory response were promoted after the co-exposure of ZEA and DON, indicated by the increased expression of BAX, Caspase-3, IL-1beta and IL-6 genes. Zearalenone 85-88 interleukin 6 Homo sapiens 168-172 34843183-0 2022 The mineralocorticoid receptor blocker spironolactone lowers plasma interferon-gamma and interleukin-6 in patients with type 2 diabetes and treatment-resistant hypertension. Spironolactone 39-53 interleukin 6 Homo sapiens 89-102 34289046-7 2022 Indeed, we also show that IL-6 cytokine is significantly increased when lung epithelial cells are exposed to Pneumocystis beta-glucans, and that this response could be blocked with preincubation with a specific antibody to EphA2. beta-Glucans 122-134 interleukin 6 Homo sapiens 26-30 35087566-9 2021 Based on the CTD database, PPARG, ADAM12, IL6, SMAD3, and TIMP2 were identified to interact with selenium, sodium selenite, and T-2 toxin. Sodium Selenite 107-122 interleukin 6 Homo sapiens 42-45 34843183-6 2022 RESULTS: Spironolactone significantly reduced plasma IFN-gamma and IL-6 while IL-17A, TNF-alpha, IL-1beta and IL-10 were unchanged. Spironolactone 9-23 interleukin 6 Homo sapiens 67-71 31964198-9 2022 A significant discriminative role of interleukin-6, presepsin and pentraxin-3 for presence of L-PrE, with cutoff values of 39.74 pg/mL, 309.88 mg/L and 34.96 ng/mL, respectively, were reported in a ROC curve analysis. l-pre 94-99 interleukin 6 Homo sapiens 37-50 34843183-7 2022 IL-6 was more sensitive to higher doses of spironolactone. Spironolactone 43-57 interleukin 6 Homo sapiens 0-4 34843183-12 2022 In macrophages in vitro, spironolactone suppressed lipopolysaccharide (LPS)-induced TNF-alpha, IL-6, IL-1beta and IL-10 levels. Spironolactone 25-39 interleukin 6 Homo sapiens 95-99 34843183-13 2022 CONCLUSION: The antihypertensive action of spironolactone in resistant hypertensive patients is associated with suppressed IFN-gamma and IL-6 and not IL-17A. Spironolactone 43-57 interleukin 6 Homo sapiens 137-141 3062144-5 1988 IL-1, TNF alpha and IL-6 also affect changes in metabolism by changing levels of circulating insulin, glucagon and corticosterone. Glucagon 102-110 interleukin 6 Homo sapiens 20-24 2573434-2 1989 Calcitriol inhibited the proliferation of T lymphocytes stimulated in the absence of monocytes with phytohemagglutinin (PHA) and either a monocytic culture supernatant or a combination of monocyte-derived interleukin 1 and interleukin 6. Calcitriol 0-10 interleukin 6 Homo sapiens 188-236 2572101-1 1989 Skin biopsies from 5 patients with chronic plaque psoriasis were examined to test the effect of topical treatment with a new synthetic vitamin D3 analogue, MC 903, on epidermal interleukin 6 (IL-6) and tumour necrosis factor alpha (TNF alpha). Cholecalciferol 135-145 interleukin 6 Homo sapiens 177-190 2851586-7 1988 As this fused protein had a Phe-Arg-Ala sequence at the junction of hIL-2 and BSF-2, it was possible to process mature BSF-2 from the fused BSF-2 by treatment with kallikrein and aminopeptidase P. From 1 liter of E. coli culture, 45 mg of mature BSF-2 was purified; it had a relative biological activity equal to that of natural BSF-2 purified from T cells. Phenylalanine 28-31 interleukin 6 Homo sapiens 78-83 2851586-7 1988 As this fused protein had a Phe-Arg-Ala sequence at the junction of hIL-2 and BSF-2, it was possible to process mature BSF-2 from the fused BSF-2 by treatment with kallikrein and aminopeptidase P. From 1 liter of E. coli culture, 45 mg of mature BSF-2 was purified; it had a relative biological activity equal to that of natural BSF-2 purified from T cells. Phenylalanine 28-31 interleukin 6 Homo sapiens 119-124 2851586-7 1988 As this fused protein had a Phe-Arg-Ala sequence at the junction of hIL-2 and BSF-2, it was possible to process mature BSF-2 from the fused BSF-2 by treatment with kallikrein and aminopeptidase P. From 1 liter of E. coli culture, 45 mg of mature BSF-2 was purified; it had a relative biological activity equal to that of natural BSF-2 purified from T cells. Phenylalanine 28-31 interleukin 6 Homo sapiens 119-124 2851586-7 1988 As this fused protein had a Phe-Arg-Ala sequence at the junction of hIL-2 and BSF-2, it was possible to process mature BSF-2 from the fused BSF-2 by treatment with kallikrein and aminopeptidase P. From 1 liter of E. coli culture, 45 mg of mature BSF-2 was purified; it had a relative biological activity equal to that of natural BSF-2 purified from T cells. Phenylalanine 28-31 interleukin 6 Homo sapiens 119-124 3278321-6 1988 CDF is first enriched by three successive chromatographic procedures that utilize anion exchange, hydroxyapatite, and phenyl-Superose. phenyl-superose 118-133 interleukin 6 Homo sapiens 0-3 3006091-2 1986 The specific binding and internalization of human 125I-labeled LDL are dose-dependently increased in HSF by CA of the verapamil series (verapamil, anipamil, gallopamil, ronipamil, and diltiazem), but neither by CA of the dihydropyridine series (nifedipine, nitrendipine) nor by flunarizine. Diltiazem 184-193 interleukin 6 Homo sapiens 101-104 6352808-3 1983 The inhibitors of methyltransferase, SIBA, adenosine, or HEH showed a dose-dependent inhibitory effect not only on phospholipid methylation but also on serine esterase activation and on BCDF-induced IgG production; DFP inhibited IgG production but not phospholipid methylation. 2-hydroxyethylhydrazine 57-60 interleukin 6 Homo sapiens 186-190 33930279-5 2021 IL-1beta, IL-6 and osteopontin (OPN) were more strongly inhibited by SAC than in colchicine. Colchicine 81-91 interleukin 6 Homo sapiens 10-14 33903806-9 2021 Significant positive correlations were observed between metabolites (including pseudouridine, l-phenylalanine, and p-hydroxyphenylacetic acid) and IL-6 levels only in ESRD group. Phenylalanine 94-109 interleukin 6 Homo sapiens 147-151 33856733-7 2021 Plasma IL-6 decreased significantly in the crocin group at the end of week 12 compared to baseline (p = .037), whereas no significant change was observed in the placebo group. crocin 43-49 interleukin 6 Homo sapiens 7-11 33851329-8 2022 We found that IL-6, TNF-alpha, IFN-gamma, and LC3II contents increased with the increase in Cr(VI) concentration. chromium hexavalent ion 92-98 interleukin 6 Homo sapiens 14-18 33936205-13 2021 It was reported that four out of six sites in the cytosine phosphate guanine (CpG) island IL6 promoter had a lower degree of methylation, and two other sites in patients with RAS had greater methylation compared with control, but not statistically significant. cytosine phosphate guanine 50-76 interleukin 6 Homo sapiens 90-93 33549578-6 2021 Data from the enzyme-linked immunosorbent assay (ELISA) showed that both coelonin (10 and 20 mug/ml) and militarine (5 and 10 mug/ml) mitigated PM2.5-induced inflammation by reducing the generation of inflammatory factors, including interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha). militarine 105-115 interleukin 6 Homo sapiens 233-246 33549578-6 2021 Data from the enzyme-linked immunosorbent assay (ELISA) showed that both coelonin (10 and 20 mug/ml) and militarine (5 and 10 mug/ml) mitigated PM2.5-induced inflammation by reducing the generation of inflammatory factors, including interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha). militarine 105-115 interleukin 6 Homo sapiens 248-252 33578085-8 2021 The colloidal mercuric formulation upregulated the expression of TGF-beta, IL-6 and TNF-alpha, due to the presence of arsenic and other organic compounds such as piperine. piperine 162-170 interleukin 6 Homo sapiens 75-79 33516901-4 2021 TCS at concentrations between 0.05-5 microM consistently increased the secretion of IL-1beta, IL-6, and TNFalpha within 24 h of exposure and the increases often maintained out to 6 days of exposure. Triclosan 0-3 interleukin 6 Homo sapiens 94-98 3085988-1 1986 Sequential extraction of human spleen membranes with sodium cholate and n-butanol removes endogenous lipids and renders glucocerebrosidase activity dependent upon exogenous acidic lipids (e.g., phosphatidylserine, gangliosides) and a heat-stable activator protein (HSF). 1-Butanol 72-81 interleukin 6 Homo sapiens 265-268 33927068-9 2021 After 10 mumol/L PDTC treatment, the mRNA and protein expressions of IL-6, IL-1beta, and TNF-alpha were detected by RT-qPCR and ELISA. prolinedithiocarbamate 17-21 interleukin 6 Homo sapiens 69-73 33927068-16 2021 The mRNA and protein expressions of IL-6, IL-1beta, and TNF-alpha in the LPS+PDTC (10 mumol/L) group were lower than those in the LPS group (all P<0.05). prolinedithiocarbamate 77-81 interleukin 6 Homo sapiens 36-40 33550900-6 2021 miR-138 overexpression rescued the migratory and invasive ability of HTR-8/SVneo and JEG-3 cells inhibited by LPS stimulation, and decreased LPS-induced TNF-alpha and IL-6 levels. mir-138 0-7 interleukin 6 Homo sapiens 167-171 2511437-7 1989 The 23-bp oligonucleotide designated AR1 from within the IL-6 enhancer region (-173 to -151) contains a CGTCA motif and bound nuclear proteins that also associated with c-fos oligonucleotides containing either an intact SRE or AP-1-like site. 23-bp oligonucleotide 4-25 interleukin 6 Homo sapiens 57-61 2789018-7 1989 Combined immunoprecipitation, immunoblotting, and immunoaffinity chromatography experiments reveal additional IL-6 species with mobilities in sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reducing conditions corresponding to molecular masses 17-19 kDa and 45 kDa, suggesting that this cytokine undergoes further alterations. polyacrylamide 165-179 interleukin 6 Homo sapiens 110-114 2422035-8 1986 Besides glucocorticoids and triiodothyronine a non-dialyzable factor (HSF) derived from rat Kupffer cells or human peripheral blood monocytes was found to be able to stimulate alpha 2-macroglobulin synthesis in hepatocytes. Triiodothyronine 28-44 interleukin 6 Homo sapiens 70-73 2472117-2 1989 The relative positions of four half-cystines in human interleukin-6 (IL-6) match four of the five in human granulocyte colony stimulating factor. half- 31-36 interleukin 6 Homo sapiens 54-67 2472117-2 1989 The relative positions of four half-cystines in human interleukin-6 (IL-6) match four of the five in human granulocyte colony stimulating factor. half- 31-36 interleukin 6 Homo sapiens 69-73 2472117-3 1989 Labeling experiments of recombinant interleukin-6 with tritiated iodoacetate confirmed that the molecule forms two intramolecular disulfide bonds and contains no detectable level of free sulfhydryls. tritiated iodoacetate 55-76 interleukin 6 Homo sapiens 36-49 33854710-12 2021 ITIID&CP had the highest IL-6 and IL-1beta/IL-10 ratios. itiid&cp 0-8 interleukin 6 Homo sapiens 25-29 4084549-5 1985 Of special interest, tyrosine A, phenylalanine A, tryptophan B1, and tryptophan B2 were found to be located close to a cluster of aliphatic residues, indicating that the hydrophobic site of the HSF is conformationally rigid and its tertiary structure very compact. tyrosine a 21-31 interleukin 6 Homo sapiens 194-197 33625693-0 2021 Correction to: Citrate high volume on-line hemodiafiltration modulates serum Interleukin-6 and Klotho levels: the multicenter randomized controlled study "Hephaestus". Citric Acid 15-22 interleukin 6 Homo sapiens 77-90 3131326-6 1988 "Uninduced" human FS-4 fibroblasts as well as those induced with interleukin-1 alpha, tumor necrosis factor, or bacterial lipopolysaccharide secrete at least five forms of IFN-beta 2 of apparent molecular mass in the range from 23 to 30 kDa which can be resolved by polyacrylamide gel electrophoresis under denaturing and reducing conditions. polyacrylamide 266-280 interleukin 6 Homo sapiens 172-182 3131326-10 1988 Human monocytes induced with bacterial lipopolysaccharide also secrete several distinct forms of IFN-beta 2 in the size range from 23 to 30 kDa which co-migrate in polyacrylamide gels with those obtained from FS-4 cells. polyacrylamide 164-178 interleukin 6 Homo sapiens 97-107 3276786-4 1988 We observed that the IFN-beta 2 gene is transcribed at a low level in uninduced FS-4 cells and that this transcriptional activity is increased 2- to 3-fold in cycloheximide-treated cells, 20- to 35-fold in IL-1 alpha-treated cells, and 5- to 15-fold in TNF-treated cells. Cycloheximide 159-172 interleukin 6 Homo sapiens 21-31 3276786-6 1988 The enhancing effect of IL-1 alpha on IFN-beta 2 gene transcription, but not that of TNF, PDGF, or IFN-beta 1, is inhibited by cycloheximide, suggesting that newly-synthesized protein is involved in the increase in IFN-beta 2 transcription in response to IL-1 alpha but not in the response to the other stimuli. Cycloheximide 127-140 interleukin 6 Homo sapiens 38-48 3276786-6 1988 The enhancing effect of IL-1 alpha on IFN-beta 2 gene transcription, but not that of TNF, PDGF, or IFN-beta 1, is inhibited by cycloheximide, suggesting that newly-synthesized protein is involved in the increase in IFN-beta 2 transcription in response to IL-1 alpha but not in the response to the other stimuli. Cycloheximide 127-140 interleukin 6 Homo sapiens 215-225 33291049-7 2021 Furthermore, in patients with PT, salivary IL-6 levels were inversely associated (P-trend) with the number of teeth (p < 0.001), and directly associated with the proportional extent of PT (CAL, p = 0.006; PPD, p = 0.009; FMBS, p < 0.001). fmbs 221-225 interleukin 6 Homo sapiens 43-47 33022353-6 2021 Overexpression of duIKKalpha dramatically increased NF-kappaB activity and induced the expression of duck cytokines IFN-beta, IL-1beta, IL-6, IL-8 and RANTES in DEFs. duikkalpha 18-28 interleukin 6 Homo sapiens 136-140 6946268-8 1981 Prostacyclin production in response to bradykinin drops in HSF as they are obtained from individuals of increasing chronologic age. Epoprostenol 0-12 interleukin 6 Homo sapiens 59-62 3496595-1 1987 A 26-kDa protein, originally described in human fibroblasts superinduced for interferon beta (IFN-beta) production, and termed IFN-beta 2 by other investigators, is induced by cycloheximide and by a 22-kDa, interleukin 1 (IL-1)-related factor. Cycloheximide 176-189 interleukin 6 Homo sapiens 127-137 6573232-6 1983 Monocytes (but not lymphocytes) incubated with supernatants containing HSF increased their production of prostaglandin E2, F2 alpha, and thromboxane B2 by 169, 53, and 49%, respectively. Thromboxane B2 137-151 interleukin 6 Homo sapiens 71-74 6573232-9 1983 Collectively, these data suggest that HSF-mediated inhibition of lymphocyte proliferation may occur in part through the augmented production of prostaglandins and/or thromboxane B2 by human monocytes. Thromboxane B2 166-180 interleukin 6 Homo sapiens 38-41 33336605-11 2021 Conclusion: Pretreatment with azithromycin decreased the expression of IL-6 and IL-8 mRNA and the release of IL-8 in bronchial epithelial cells exposed to cigarette smoke. Azithromycin 30-42 interleukin 6 Homo sapiens 71-75 34058440-0 2021 Network pharmacology identifies IL6 as an important hub and target of tibolone for drug repurposing in traumatic brain injury. tibolone 70-78 interleukin 6 Homo sapiens 32-35 33146673-7 2021 RESULTS: The network pharmacology research showed that TCM could decrease IL-6 using several compounds, such as quercetin, ursolic acid, luteolin, and rutin. Luteolin 137-145 interleukin 6 Homo sapiens 74-78 33146673-11 2021 Quercetin, ursolic acid, luteolin, and rutin could inhibit COVID-19 by downregulating IL-6. Luteolin 25-33 interleukin 6 Homo sapiens 86-90 34058440-8 2021 Thus, we identified IL6 as a cellular node which we then validated using molecular mechanics-generalized born surface area (MMGBSA) and docking to explore which tibolone metabolite might interact with this protein. tibolone 161-169 interleukin 6 Homo sapiens 20-23 33300903-7 2021 The weaned piglets of the HMSeBA group had lower serum IL-1beta and IL-6 than the piglets of the control group at 2 h of LPS challenge. 2-hydroxy-4-methylselenobutanoic acid 26-32 interleukin 6 Homo sapiens 68-72 6164058-5 1980 Both are induced by poly(rI.rC), but IFN-beta 2 mRNA is induced to about 10% in cells by cycloheximide treatment alone whereas under these conditions IFN-beta 1 is not induced. Cycloheximide 89-102 interleukin 6 Homo sapiens 37-47 34058440-10 2021 In conclusion, our study demonstrates key hubs involved in TBI pathology which indicates IL6 as a target molecule of tibolone as drug repurposing for TBI therapy. tibolone 117-125 interleukin 6 Homo sapiens 89-92 34018029-11 2021 Among patients with IRRs, those receiving ibrutinib-obinutuzumab had lower post-obinutuzumab increases in IL-6, IL-8, IL-10, and MCP-1 (P < 0.04) than patients receiving chlorambucil-obinutuzumab. ibrutinib 42-51 interleukin 6 Homo sapiens 106-110 34053084-6 2021 The procoagulant effect of IL-6 was inhibited by colchicine, which blocks neutrophil degranulation. Colchicine 49-59 interleukin 6 Homo sapiens 27-31 32951264-10 2021 In addition, crocin/crocetin at low concentrations caused an elevation in mRNA expression of anti-inflammatory cytokines (transforming growth factor-beta, interleukin-10 [IL-10], and IL-4), while at higher doses (25 and 50 microM) they led to lowering inflammatory cytokines (IL-1beta, IL-6, IL-17, and interferon gamma). crocin 13-19 interleukin 6 Homo sapiens 286-290 32951264-10 2021 In addition, crocin/crocetin at low concentrations caused an elevation in mRNA expression of anti-inflammatory cytokines (transforming growth factor-beta, interleukin-10 [IL-10], and IL-4), while at higher doses (25 and 50 microM) they led to lowering inflammatory cytokines (IL-1beta, IL-6, IL-17, and interferon gamma). crocetin 20-28 interleukin 6 Homo sapiens 286-290 33986196-3 2021 We found that beta-glucan-trained miR-9-5p-/- monocytes showed decreased IL-1beta, IL-6, and TNF-alpha production after LPS stimulation. beta-Glucans 14-25 interleukin 6 Homo sapiens 83-87 32674107-2 2021 LMT-28 suppresses the activation of the IL-6-mediated signaling by direct targeting of gp130. LMT-28 0-6 interleukin 6 Homo sapiens 40-44 32674107-12 2021 CONCLUSION: Combination treatment with LMT-28 and metformin significantly ameliorates arthritic symptoms in CIA by suppressing Th17 differentiation and IL-6 signaling. LMT-28 39-45 interleukin 6 Homo sapiens 152-156 34051020-9 2021 Azilsartan reduced AGEs-induced production of proinflammatory cytokines, such as IL-1alpha, TNF-beta, and IL-6. azilsartan 0-10 interleukin 6 Homo sapiens 106-110 34035828-10 2021 The molecular docking results showed that quercetin, formononetin, kaempferol, isorhamnetin, beta-sitosterol had a good binding activity with VEGFA, IL6, TNF, AKT1, and TP53. gamma-sitosterol 93-108 interleukin 6 Homo sapiens 149-152 34048811-17 2021 miR-30 targeted IL-6 and induced apoptosis. mir-30 0-6 interleukin 6 Homo sapiens 16-20 33365026-6 2020 In vitro treatment with 1,25(OH)2D3 reduced proinflammatory cytokines (IL-6, CCL-2, IL-23A, IL-15) whereas anti-inflammatory cytokines (IL-10 and PD-L1) rose both in APS-type 1 diabetes and APS-Addison s disease. Calcitriol 24-35 interleukin 6 Homo sapiens 71-75 34012440-8 2021 Results: Iron impaired microglial function in vitro regarding phagocytosis and markers of inflammation; this was regulated by clozapine, reflected in reduced release of IL-6 and normalization of neuronal phagocytosis. Clozapine 126-135 interleukin 6 Homo sapiens 169-173 32977089-1 2020 A massively parallel single particle sensing method based on core-satellite formation of Au nanoparticles was introduced for the detection of interleukin 6 (IL-6). Gold 89-91 interleukin 6 Homo sapiens 142-155 32977089-1 2020 A massively parallel single particle sensing method based on core-satellite formation of Au nanoparticles was introduced for the detection of interleukin 6 (IL-6). Gold 89-91 interleukin 6 Homo sapiens 157-161 32977089-3 2020 In this method, the hue (color) value of thousands of 67 nm Au nanoparticles immobilized on a glass coverslip surface is analyzed by a Matlab code before and after the addition of reporter nanoparticles containing IL-6 as target protein. Gold 60-62 interleukin 6 Homo sapiens 214-218 33713324-5 2021 In the present study, we observed that FK866 (a specific noncompetitive NAMPT inhibitor) dose-dependently inhibited lipopolysaccharide (LPS)-induced proinflammatory mediator (interleukin (IL)-6, IL-1beta, inducible nitric oxide synthase, nitric oxide and reactive species) level increase in BV2 microglia cultures. N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide 39-44 interleukin 6 Homo sapiens 175-193 33946744-8 2021 Altered mRNA expression, including activated PIM kinase and c-Myc, was identified in Apitolisib resistant cells (H1975GR) by an IL-6/STAT3 pathway array and validated by Western blot. 1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one 85-95 interleukin 6 Homo sapiens 128-132 33520015-11 2020 Finally, 6 key proteins of TNF, IL-10, IL-2, IL-6, STAT1 and CCL2 were selected and successfully docked with 4 active ingredients of quercetin, luteolin, wogonin and kaempferol. Luteolin 144-152 interleukin 6 Homo sapiens 45-49 33520015-11 2020 Finally, 6 key proteins of TNF, IL-10, IL-2, IL-6, STAT1 and CCL2 were selected and successfully docked with 4 active ingredients of quercetin, luteolin, wogonin and kaempferol. wogonin 154-161 interleukin 6 Homo sapiens 45-49 33460754-8 2021 RESULTS: MSW reduced the joint swelling rate in gouty arthritis model and inhibited MSU induced up-regulation of IL-1beta, TNF-alpha, and IL-6 protein levels in serum and synovial fluid. [(1s)-2-(Methoxycarbonylamino)-1-Phenyl-Ethoxy]-Propyl-Phosphinic Acid 9-12 interleukin 6 Homo sapiens 138-142 33129099-8 2020 After treatment with Nano-curcumin, a significant decrease in IL-6 expression and secretion in serum and in supernatant (P = 0.0003, 0.0038, and 0.0001, respectively) and IL-1beta gene expression and secretion level in serum and supernatant (P = 0.0017, 0.0082, and 0.0041, respectively) was observed. nano-curcumin 21-34 interleukin 6 Homo sapiens 62-66 33911154-6 2021 Of the ten cytokines assayed, IL6, IL10, and TGFB1 increased with progression of PCB. pcb 81-84 interleukin 6 Homo sapiens 30-33 34056329-5 2021 Interestingly, Telmisartan inhibited TNF-alpha-induced expression and secretions of proinflammatory mediators such as interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and monocyte chemotactic protein 1 (MCP-1). Telmisartan 15-26 interleukin 6 Homo sapiens 148-161 33901737-8 2021 Furthermore, LPS-induced nitrite and IL6 production by peritoneal macrophages is inhibited by 7HF in a Ca2+-dependent manner. 7-hydroxyfrullanolide 94-97 interleukin 6 Homo sapiens 37-40 33901737-11 2021 Finally, intraperitoneal administration of 7HF lowers serum inflammatory cytokines, IFNgamma and IL6, and reduces the effects of DSS-induced colitis with respect to colon length and colon damage. 7-hydroxyfrullanolide 43-46 interleukin 6 Homo sapiens 97-100 33105404-5 2020 There were significant negative associations among firefighters between perfluorodecanoic acid (PFDeA) and total cholesterol and PFUA and interleukin-6. perfluorodecanoic acid 72-94 interleukin 6 Homo sapiens 138-151 34056329-5 2021 Interestingly, Telmisartan inhibited TNF-alpha-induced expression and secretions of proinflammatory mediators such as interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and monocyte chemotactic protein 1 (MCP-1). Telmisartan 15-26 interleukin 6 Homo sapiens 163-167 33105404-5 2020 There were significant negative associations among firefighters between perfluorodecanoic acid (PFDeA) and total cholesterol and PFUA and interleukin-6. perfluorodecanoic acid 96-101 interleukin 6 Homo sapiens 138-151 33850164-5 2021 Cromolyn and a new fluorinated analog dramatically reduced the secretion of a wide spectrum of inflammatory mediators, which included cytokines such as IL-1beta, IL-6, IL-8 and IFN-gamma, and chemokines such as CXCL10, CCL2, CCL3 and CCL4. Cromolyn Sodium 0-8 interleukin 6 Homo sapiens 162-166 33180478-7 2020 VPP and IPP reduced the protein levels of IL-6 to 227.34 +- 10.56 and 273.84 +- 22.28 pg/mL, of IL-1beta protein to 131.56 +- 23.18 and 221.14 +- 13.8 pg/mL, and of MCP-1 to 301.48 +- 19.75 and 428.68 +- 9.59 pg/mL. isoleucyl-prolyl-proline 8-11 interleukin 6 Homo sapiens 42-46 33255431-6 2020 IL-6 release was inhibited by P2X7R antagonists A438079, A839977, and AZ10606120, but not the NRTI lamivudine (3TC), P2X1R antagonist NF279, or P2Y1R antagonist MRS2179. 3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine 48-55 interleukin 6 Homo sapiens 0-4 33255431-6 2020 IL-6 release was inhibited by P2X7R antagonists A438079, A839977, and AZ10606120, but not the NRTI lamivudine (3TC), P2X1R antagonist NF279, or P2Y1R antagonist MRS2179. NF 279 134-139 interleukin 6 Homo sapiens 0-4 33255431-7 2020 P2X7R-mediated IL-6 release required extracellular Ca2+ and was blocked by Ca2+ chelator BAPTA. 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid 89-94 interleukin 6 Homo sapiens 15-19 33864624-1 2021 : "Comment on: Comparative Population Pharmacokinetics of Darunavir in SARS-CoV-2 Patients vs. HIV Patients: The Role of Interleukin6". Darunavir 58-67 interleukin 6 Homo sapiens 121-133 33864625-0 2021 Comment on "Comparative Population Pharmacokinetics of Darunavir in SARS-CoV-2 Patients vs. HIV Patients: The Role of Interleukin-6". Darunavir 55-64 interleukin 6 Homo sapiens 118-131 34055214-1 2021 We identified nitazoxanide (NTZ) as a moderate STAT3 pathway inhibitor through immunoblot analysis and a cell-based IL-6/JAK/STAT3 pathway activation assay. nitazoxanide 14-26 interleukin 6 Homo sapiens 116-120 33937285-5 2021 Among such class of drugs, azithromycin is described as azalide and is well-known for its ability to decrease the production of pro-inflammatory cytokines, including matrix metalloproteinases, tumor necrosis factor-alpha, interleukin (IL)-6, and IL-8. Azithromycin 27-39 interleukin 6 Homo sapiens 222-240 33204288-12 2020 Molecular docking showed that quercetin, kaempferol, baicalein, and wogonin have good binding activity with IL6, VEGFA, EGFR, and NFKBIA targets. wogonin 68-75 interleukin 6 Homo sapiens 108-111 33216119-9 2020 By completely inhibiting these mediators, verteporfin may be more efficacious in ameliorating LPA and/or IL6 trans-signaling-induced ocular hypertensive phenotypes in hTM cells. Verteporfin 42-53 interleukin 6 Homo sapiens 105-108 32746708-7 2021 GO and MGO increased production of pro-inflammatory such as interleukin (IL)-1beta and IL-6) and MUC5AC/5B. Pyruvaldehyde 7-10 interleukin 6 Homo sapiens 87-91 34055214-1 2021 We identified nitazoxanide (NTZ) as a moderate STAT3 pathway inhibitor through immunoblot analysis and a cell-based IL-6/JAK/STAT3 pathway activation assay. nitazoxanide 28-31 interleukin 6 Homo sapiens 116-120 32746708-9 2021 Whether ERK1/2, p38 MAPK, and NF-kappaB signaling pathway were involved in GO and MGO-induced production of pro-inflammatory cytokines (IL-1beta and IL-6) and MUC5AC/5B, we used specific inhibitors and siRNA transfection. Pyruvaldehyde 82-85 interleukin 6 Homo sapiens 149-153 33123835-9 2021 The levels of TNF-alpha and IL-6 were inhibited in IL-1beta-treated NP cells transfected with miR-125b-5p inhibitor. mir-125b 94-102 interleukin 6 Homo sapiens 28-32 32746708-10 2021 These significantly repressed GO- and MGO-induced expression of pro-inflammatory cytokines (IL-1beta and IL-6) and MUC5AC/5B. Pyruvaldehyde 38-41 interleukin 6 Homo sapiens 105-109 33497843-11 2021 The production of IL-6 by HSC-2 cells stimulated with adenine nucleotides was significantly inhibited by P2R antagonists and a p38 mitogen-activated protein kinase inhibitor, but not by extracellular signal-related kinase or c-Jun N-terminal kinase inhibitors. Adenine Nucleotides 54-73 interleukin 6 Homo sapiens 18-22 33126239-6 2020 At high concentrations (100-200 mug/ml), GA also suppressed the production of Th17-differentiation cytokines (interleukin-1beta and interleukin-6) by lipopolysaccharide (LPS)-activated dendritic cells (DCs). Glatiramer Acetate 41-43 interleukin 6 Homo sapiens 132-145 33493945-10 2021 Myo-inositol down-regulates the expression of IL-6 by phosphatidyl-inositol-3-kinase (PI3K) pathway. Inositol 0-12 interleukin 6 Homo sapiens 46-50 32404441-10 2020 Median IL-6 levels were 53.0 pg/mL in HEs and 21.0 pg/mL in HUs (p=0.07). Helium 38-41 interleukin 6 Homo sapiens 7-11 32856282-7 2020 In SARS-CoV-2 patients (n = 30), interleukin (IL)-6 and body surface area were covariates associated with darunavir oral clearance (CL/F) and volume of distribution (Vd), respectively; no covariates were identified in HIV patients (n = 25). Darunavir 106-115 interleukin 6 Homo sapiens 33-51 33155234-13 2020 CONCLUSIONS: In the treatment of children, viral encephalitis has naloxone combined with ganciclovir had a more significant effect on the decrease of levels of serum IL-1 and IL-6; naloxone combined with acyclovir in the treatment of children viral encephalitis had better effects, lower adverse reactions and lower prevalence of sequelae compared with sole medication, which is worth clinical promotion. Ganciclovir 89-100 interleukin 6 Homo sapiens 175-179 32706883-7 2020 RESULTS: Greater IL-6 reactivity to stress, measured with baseline-adjusted area under the curve, predicted 12-month decrease in flow-mediated dilatation of the brachial artery (P = 0.0005), a measure of endothelial-dependent vascular function, but not in endothelial-independent function measured with nitroglycerin-mediated dilatation (P = 0.17). Nitroglycerin 303-316 interleukin 6 Homo sapiens 17-21 33598775-6 2021 RESULTS: FCX significantly decreased LPS-induced interleukin (Il)6, Il1b, and tumor necrosis factor alpha (Tnf) mRNA abundance and TNFalpha secretion. fucoxanthin 9-12 interleukin 6 Homo sapiens 49-66 33336605-9 2021 When cells were pretreated with azithromycin and exposed to 5% CSE for 3 h, there was a significant dose-dependent decrease in the expression of IL-6 mRNA. Azithromycin 32-44 interleukin 6 Homo sapiens 145-149 33336605-10 2021 A final concentration of 9 microg/mL of azithromycin was sufficient to decrease IL-6, IL-8 mRNA, and extracellular IL-8 levels. Azithromycin 40-52 interleukin 6 Homo sapiens 80-84 33537800-12 2021 IL-6, TNF-alpha, NF-kappaB and IFN-gamma levels were negatively correlated with miR-125b expression, and were inhibited by miR-125b in PBMCs. mir-125b 80-88 interleukin 6 Homo sapiens 0-4 33175424-7 2021 Also, papaverine resulted in significant increase of the levels in BDNF, pCREB, IL-10 and GSH along with significant decrease of TNF-alpha, IL-6 and TBARS in different brain areas of PAE group. Papaverine 6-16 interleukin 6 Homo sapiens 140-144 33278444-9 2021 Moreover, quercetin-glycyrrhizin nanogels were more effective in down-regulating the inflammation-related gene expression of tumor necrosis factor-alpha, interleukin-6, inducible nitric oxide synthase and monocyte chemotactic protein-1. Glycyrrhizic Acid 20-32 interleukin 6 Homo sapiens 154-167 32755990-11 2020 DHT pre-treatment significantly decreased IFNgamma-induced expression of HLA-DR, mRNA expression of iNOS, COX2 and MCP1, and secretion of IL1, IL2, IL5, IL6, MCP1 and GCSF. Dihydrotestosterone 0-3 interleukin 6 Homo sapiens 153-156 32898315-10 2020 DGLA and ETA (10 muM) decreased EC production of sICAM-1, MCP-1, RANTES and IL-6. 8,11,14-Eicosatrienoic Acid 0-4 interleukin 6 Homo sapiens 76-80 33537800-14 2021 RAF1 reversed the role of miR-125b in attenuating IL-6, TNF-alpha, NF-kappaB and IFN-gamma levels in PBMCs. mir-125b 26-34 interleukin 6 Homo sapiens 50-54 32363977-3 2020 Therefore in the current study, phloretin was formulated in microemulsion of 11 nm size, and its in vitro anti-inflammatory properties were explored using histamine and IL-6 release inhibition assays, protease inhibition assay, and membrane stabilization potential. Phloretin 32-41 interleukin 6 Homo sapiens 169-173 32363977-5 2020 Results proved that both phloretin and phloretin microemulsion significantly inhibited the release of the inflammatory mediators histamine and IL-6, inhibited protease action, and exhibited membrane stabilization potential. Phloretin 25-34 interleukin 6 Homo sapiens 143-147 32363977-5 2020 Results proved that both phloretin and phloretin microemulsion significantly inhibited the release of the inflammatory mediators histamine and IL-6, inhibited protease action, and exhibited membrane stabilization potential. Phloretin 39-48 interleukin 6 Homo sapiens 143-147 33584719-6 2020 Lung injury observed by histopathologic changes and magnetic resonance imaging at 24 h indicated that increased TNF-alpha and IL-6 may initiate CSS in the lung, resulting in the continual production of inflammatory cytokines. thiocysteine 144-147 interleukin 6 Homo sapiens 126-130 33584719-7 2020 We hypothesize that TNF-alpha and IL-6 may contribute to the occurrence of CSS in COVID-19. thiocysteine 75-78 interleukin 6 Homo sapiens 34-38 33537800-16 2021 Thus, it was suggested that miR-125b served important roles in the occurrence and development of TB by decreasing the levels of IL-6, TNF-alpha, NF-kappaB and IFN-gamma by inhibiting RAF1. mir-125b 28-36 interleukin 6 Homo sapiens 128-132 33786819-5 2021 KEY RESULTS: Oxoglaucine suppressed the expression of pro-inflammatory and apoptosis-related cytokines, such as TNF-alpha, IL-6, IL-1beta, MMP-13, CASP-3, BAX, and prevented matrix degradation in OA chondrocytes. oxoglaucine 13-24 interleukin 6 Homo sapiens 123-127 33489875-5 2020 At all three time points, Emodin (50 mg/kg) reduced inflammatory cell (i.e. CD11b+ and F4/80+) recruitment, cytokine (i.e. TNFalpha, IL1alpha/beta, IL6, CCL2, CXCL5) and pro-inflammatory enzymes (i.e. COX-2, NOS2) expression in the tumor microenvironment, while promoting recruitment of CD3+ T lymphocytes at 14 weeks. Emodin 26-32 interleukin 6 Homo sapiens 148-151 32967203-9 2020 We found that piperine inhibited NF-kappaB by the activation of Nrf-2, blocking downstream inflammatory mediators/cytokines (TNF-alpha, IL-6, IL-1beta, Cox-2, PGE-2, iNOS, NO, MPO), triggering an antioxidant response machinery (HO-1, NQO-1, GSH, GR, GPx, CAT, SOD), scavenging ROS, and decreasing lipid peroxidation. piperine 14-22 interleukin 6 Homo sapiens 136-140 33855019-8 2021 When additionally stimulating macrophages with the ionophore nigericin, we observed an enhanced formation of the NLRP3 inflammasome, increased levels of cell death, and higher secreted protein levels of IL-1beta and IL-6 on compliant substrates. Nigericin 61-70 interleukin 6 Homo sapiens 216-220 32907591-0 2020 Caffeine supplementation induces higher IL-6 and IL-10 plasma levels in response to a treadmill exercise test. Caffeine 0-8 interleukin 6 Homo sapiens 40-44 32907591-3 2020 The aim of this study was to determine the effects of caffeine supplementation on plasma levels of cytokines, mainly IL-10 and IL-6, in response to exercise. Caffeine 54-62 interleukin 6 Homo sapiens 127-131 32907591-11 2020 Caffeine supplementation influenced only IL-6 (3.04 +- 0.40 vs. 3.89 +- 0.62 pg mL- 1, p = 0.003) and IL-10 (2.42 +- 0.54 vs. 3.47 +- 0.72 pg mL- 1, p = 0.01) levels, with higher concentrations after exercise in the supplemented condition. Caffeine 0-8 interleukin 6 Homo sapiens 41-45 32907591-13 2020 CONCLUSIONS: The results of the present study indicate a significant influence of caffeine supplementation increasing the response to exercise of two essential cytokines such as IL-6 and IL-10. Caffeine 82-90 interleukin 6 Homo sapiens 178-182 33505216-6 2021 The anti-inflammatory mechanism of GL and GA is realized via cytokines like interferon-gamma, tumor necrotizing factor-alpha, interleukin- (IL-) 1beta, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, and IL-17. gl 35-37 interleukin 6 Homo sapiens 164-168 33540416-12 2021 RESULTS: 1,25 Dihydroxycholecalciferol (1,25 (OH)2 D3) significantly reduced TNF-alpha production in LPS-activated ESCs and TNF-alpha and IL-6 production by LTA-stimulated WECs. Calcitriol 9-38 interleukin 6 Homo sapiens 138-142 33668814-7 2021 In addition, polyphenols cause immunomodulatory effects against allergic reaction and autoimmune disease by inhibition of autoimmune T cell proliferation and downregulation of pro-inflammatory cytokines (interleukin-6 (IL-6), IL-1, interferon-gamma (IFN-gamma)). Polyphenols 13-24 interleukin 6 Homo sapiens 204-217 33540416-12 2021 RESULTS: 1,25 Dihydroxycholecalciferol (1,25 (OH)2 D3) significantly reduced TNF-alpha production in LPS-activated ESCs and TNF-alpha and IL-6 production by LTA-stimulated WECs. Calcitriol 40-53 interleukin 6 Homo sapiens 138-142 31912578-9 2020 Furthermore, emodin positively regulated TUG1 expression and TUG1 silencing could reverse the efficacy of emodin on IL-6 and MCP-1 expressions. Emodin 106-112 interleukin 6 Homo sapiens 116-120 32726647-4 2020 OxLDL priming induced a proinflammatory memory with increased production of inflammatory cytokines such as IL-6, IL-8 and MCP-1 in response to PAM3cys4 restimulation. pam3cys4 143-151 interleukin 6 Homo sapiens 107-111 33179090-9 2021 Co-treatment with apelin-36 alleviated LPS-induced lung injury and pulmonary edema, reduced the levels of pro-inflammatory cytokines, including interleukin-6, monocyte chemoattractant protein-1 and tumor necrosis factor-alpha, in BALF, and inhibited apoptosis in the lung tissues. APELIN-36 18-27 interleukin 6 Homo sapiens 144-157 33668814-7 2021 In addition, polyphenols cause immunomodulatory effects against allergic reaction and autoimmune disease by inhibition of autoimmune T cell proliferation and downregulation of pro-inflammatory cytokines (interleukin-6 (IL-6), IL-1, interferon-gamma (IFN-gamma)). Polyphenols 13-24 interleukin 6 Homo sapiens 219-223 33354576-4 2020 Our results illustrated that HG levels induced IL-1beta, IL-6, TGF-beta1, and VEGF expression and that tangeretin significantly reduced HG-induced IL-1beta, IL-6, TGF-beta1, and VEGF expression in human RPE cells. Mercury 136-138 interleukin 6 Homo sapiens 157-161 32832542-6 2020 Simultaneously, emodin downregulated H2O2-induced inflammatory factors, including IL-6, NO, and TNF-alpha, and alleviated H2O2-induced oxidative stress and mitochondrial dysfunction in SH-SY5Y cells. Emodin 16-22 interleukin 6 Homo sapiens 82-86 33644593-6 2021 In addition, feprazone prevented FFA-induced expression and secretion of proinflammatory cytokines and chemokines, such as chemokine ligand 5 (CCL5), interleukin-6 (IL-6), and interleukin-8 (IL-8). Feprazone 13-22 interleukin 6 Homo sapiens 150-163 31142476-0 2020 Analysis of IL-6 measurement in patients with GCA treated with tocilizumab should consider concomitant treatment with prednisone. Prednisone 118-128 interleukin 6 Homo sapiens 12-16 33287198-4 2020 According to the results, PGFE suppressed pro-inflammatory cytokines such as tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-6, and pro-inflammatory mediators such as inducible nitric oxide synthase and cyclooxygenase-2 through heme oxygenase-1 expression in human periodontal ligament cells stimulated with Porphyromonas gingivalis lipopolysaccharide (PG-LPS). pgfe 26-30 interleukin 6 Homo sapiens 134-138 32781854-7 2020 Moreover, KM6 reduced the levels of inflammation markers PGE2, COX2, IL-1beta and IL6 and metastasis markers MMP-2 and MMP-9. km6 10-13 interleukin 6 Homo sapiens 82-85 33644593-6 2021 In addition, feprazone prevented FFA-induced expression and secretion of proinflammatory cytokines and chemokines, such as chemokine ligand 5 (CCL5), interleukin-6 (IL-6), and interleukin-8 (IL-8). Feprazone 13-22 interleukin 6 Homo sapiens 165-169 33557199-7 2021 IL-6, MMP1, and MMP10 levels were also increased in the efOA-CPs. efoa-cps 56-64 interleukin 6 Homo sapiens 0-4 32535321-0 2020 Immunomodulatory activity of a novel polysaccharide extracted from Huangshui on THP-1 cells through NO production and increased IL-6 and TNF-alpha expression. Polysaccharides 37-51 interleukin 6 Homo sapiens 128-132 32676868-3 2020 The aim of this study was to assess the effect of colchicine as anti-inflammatory drug on the serum levels of the inflammatory markers (CRP) and (IL-6) in patients with chronic (RHD). Colchicine 50-60 interleukin 6 Homo sapiens 146-150 32676868-10 2020 Mean (IL-6) level was 113.57 +- 37.4 ng/l before and became 45.57 +- 20.39 ng/l 1 month after colchicine therapy (P = 0.001). Colchicine 94-104 interleukin 6 Homo sapiens 6-10 34046187-5 2021 IL-6 and AGEs panel had AUC 0.795 for differentiating DM-SD from DM-DD (90.6% sensitivity). dm-sd 54-59 interleukin 6 Homo sapiens 0-4 32676868-11 2020 CONCLUSION: In this pilot study, using colchicine as anti-inflammatory drug in patients with chronic (RHD) significantly reduced the serum inflammatory markers (CRP) and (IL-6), thus helping in ameliorating their chronic inflammatory state. Colchicine 39-49 interleukin 6 Homo sapiens 171-175 32440348-3 2020 GlcN and GlcNAc (0.5 mM each) alone did not suppress IL-6 production, whereas Cit (0.5 mM) did significantly suppress IL-6 production. Citrulline 78-81 interleukin 6 Homo sapiens 118-122 32440348-4 2020 Furthermore, the combined effect of Cit, GlcNAc and GlcN was examined; Cit + GlcN and Cit + GlcNAc significantly suppressed not only IL-6 production, but also phosphorylation of ERK1/2. Citrulline 71-74 interleukin 6 Homo sapiens 133-137 32440348-4 2020 Furthermore, the combined effect of Cit, GlcNAc and GlcN was examined; Cit + GlcN and Cit + GlcNAc significantly suppressed not only IL-6 production, but also phosphorylation of ERK1/2. Glucosamine 52-56 interleukin 6 Homo sapiens 133-137 32440348-4 2020 Furthermore, the combined effect of Cit, GlcNAc and GlcN was examined; Cit + GlcN and Cit + GlcNAc significantly suppressed not only IL-6 production, but also phosphorylation of ERK1/2. Citrulline 71-74 interleukin 6 Homo sapiens 133-137 32440348-5 2020 Similarly, combination of GlcN + GlcNAc significantly suppressed IL-6 production and phosphorylation of ERK1/2. Glucosamine 26-30 interleukin 6 Homo sapiens 65-69 32687403-0 2020 SABA use could be a confounding factor for interpreting increased IL-6. 3-(2-(4-azidobenzamidino)ethyl)-5-hydroxyindole 0-4 interleukin 6 Homo sapiens 66-70 33575081-4 2021 Moreover, we found that IL-6 from dbcAMP- or temozolomide (TMZ)-induced senescent cells facilitates the glycolytic phenotype of GBM cells and that inhibiting the IL-6-related pathway hinders the proglycolytic effect of either agent. Temozolomide 45-57 interleukin 6 Homo sapiens 24-28 32141427-5 2020 Using a loss-of-function assay and inhibitor treatment, we found that AGT knockdown inhibited the increase of IL-1beta, matrix metalloproteinase (MMP)-13 and nitrite in IL-6-induced chondrocytes through blocking the renin-angiotensin system (RAS). Nitrites 158-165 interleukin 6 Homo sapiens 169-173 32959231-13 2020 CONCLUSION: In conclusion, HCMV-induced miR-34c or miR-138 involves in the activation of IL6/STAT3 signaling. mir-138 51-58 interleukin 6 Homo sapiens 89-92 32760206-7 2020 The drugs triciribine and kinetin riboside activate ACE2 expression or inhibit IL-6 production in macrophages to some extent. kinetin riboside 26-42 interleukin 6 Homo sapiens 79-83 33575081-4 2021 Moreover, we found that IL-6 from dbcAMP- or temozolomide (TMZ)-induced senescent cells facilitates the glycolytic phenotype of GBM cells and that inhibiting the IL-6-related pathway hinders the proglycolytic effect of either agent. Temozolomide 45-57 interleukin 6 Homo sapiens 162-166 32458964-6 2020 In addition, Nar significantly counteracted MTX-induced increases in hepatic interleukin-6 and tumor necrosis factor-alpha. naringin 13-16 interleukin 6 Homo sapiens 77-90 32920000-6 2020 Chloroquine/hydroxychloroquine + azithromycin interacted with 6 genes (CCL2, CTSB, CXCL8, IL1B, IL6 and TNF), whereas chloroquine and azithromycin affected two additional genes (BCL2L1 and CYP3A4), which might be a reason behind a greater number of consequential diseases. Azithromycin 33-45 interleukin 6 Homo sapiens 96-99 33575081-4 2021 Moreover, we found that IL-6 from dbcAMP- or temozolomide (TMZ)-induced senescent cells facilitates the glycolytic phenotype of GBM cells and that inhibiting the IL-6-related pathway hinders the proglycolytic effect of either agent. Temozolomide 59-62 interleukin 6 Homo sapiens 24-28 32920000-7 2020 In contrast to lopinavir/ritonavir, chloroquine/hydroxychloroquine + azithromycin downregulated the expression of TNF and IL6. Azithromycin 69-81 interleukin 6 Homo sapiens 122-125 33575081-4 2021 Moreover, we found that IL-6 from dbcAMP- or temozolomide (TMZ)-induced senescent cells facilitates the glycolytic phenotype of GBM cells and that inhibiting the IL-6-related pathway hinders the proglycolytic effect of either agent. Temozolomide 59-62 interleukin 6 Homo sapiens 162-166 33575081-5 2021 In patient-derived GBM xenograft models, a specific antibody targeting the IL-6 receptor tocilizumab (TCZ) significantly prolongs the survival time of TMZ-treated mice. Temozolomide 151-154 interleukin 6 Homo sapiens 75-79 32758621-10 2020 Moreover, choline markedly enhanced the concentrations of inflammatory factors including LPS, CRP, IL-6, TNF-alpha, and CXCL1 in H. pylori-infected mice. Choline 10-17 interleukin 6 Homo sapiens 99-103 32528052-7 2020 For the pro-inflammatory markers, a moderate group effect was found between PG and HCG which was mainly caused by IL-6. pg 76-78 interleukin 6 Homo sapiens 114-118 33406371-11 2021 Vancomycin was associated with a reduction in inflammatory proteins from treated tendon supernatants (IL-6; P < .05). Vancomycin 0-10 interleukin 6 Homo sapiens 102-106 32407430-6 2020 Here we report for the first time that while stimulation with pGr alone does not directly induce cytokine secretion by bone-marrow derived macrophages (BMDMs), it programs them for enhanced secretion of proinflammatory cytokines (IL-6, TNF-alpha) and a concomitant decrease in production of the regulatory cytokine, IL-10 after Toll-like receptor (TLR) ligand stimulation. pgr 62-65 interleukin 6 Homo sapiens 230-234 32528464-7 2020 Incubation of healthy and SSc dendritic cells with etoposide, a carnitine transporter inhibitor, inhibited the production of pro-inflammatory cytokines such as IL-6 through inhibition of fatty acid oxidation. Carnitine 64-73 interleukin 6 Homo sapiens 160-164 33066009-0 2020 Choline Intake as Supplement or as a Component of Eggs Increases Plasma Choline and Reduces Interleukin-6 without Modifying Plasma Cholesterol in Participants with Metabolic Syndrome. Choline 0-7 interleukin 6 Homo sapiens 92-105 33066009-11 2020 In contrast, interleukin-6 was reduced, with both sources of choline compared to baseline, while eggs also had an effect on lowering C-reactive protein, insulin, and insulin resistance compared to baseline. Choline 61-68 interleukin 6 Homo sapiens 13-26 33466819-6 2021 Inflammation in the abdominal sepsis model, assessed by cytokine measurements, indicated exacerbation by DFX and DFO for plasma Interleukin (IL)-6 and reductions to near-control levels for DIBI and DFP. Deferoxamine 113-116 interleukin 6 Homo sapiens 128-146 33050250-2 2020 Royal jelly (RJ) modulates inflammation by regulating the levels of tumor necrosis factor (TNF)-alpha, transforming growth factor (TGF)-beta, and interleukin (IL)-6 produced by macrophages. royal jelly 0-11 interleukin 6 Homo sapiens 146-164 33050250-2 2020 Royal jelly (RJ) modulates inflammation by regulating the levels of tumor necrosis factor (TNF)-alpha, transforming growth factor (TGF)-beta, and interleukin (IL)-6 produced by macrophages. royal jelly 13-15 interleukin 6 Homo sapiens 146-164 31796217-8 2020 Interleukin 1beta, monocyte chemoattractant protein 1, and IL-6 messenger RNA expression were considerably downregulated in the small intestine of the GAL group. galactomannan 151-154 interleukin 6 Homo sapiens 59-63 31796217-9 2020 In addition, GAL treatment significantly prevented plasma interleukin 6 and monocyte chemoattractant protein 1 upregulation and diminished nitrate and nitrite levels after 3 h of intestinal reperfusion. galactomannan 13-16 interleukin 6 Homo sapiens 58-71 33092789-5 2020 TAMs increase EZH2 stability by stimulating PRMT1-mediated meR342-EZH2 formation through the secretion of interleukin-6 (IL-6) cytokine. mer342 59-65 interleukin 6 Homo sapiens 106-119 32370100-8 2020 Cell cycle analysis demonstrated that K562 cells treated with Br-Ell-SO3Na were arrested in the phase S. Moreover, the production of IL-6 increased and the expression of IL-8 was inhibited in the human PBMC treated with Br-Ell-SO3Na. br-ell-so3na 62-74 interleukin 6 Homo sapiens 133-137 32370100-8 2020 Cell cycle analysis demonstrated that K562 cells treated with Br-Ell-SO3Na were arrested in the phase S. Moreover, the production of IL-6 increased and the expression of IL-8 was inhibited in the human PBMC treated with Br-Ell-SO3Na. br-ell-so3na 220-232 interleukin 6 Homo sapiens 133-137 33011734-12 2020 Postoperative serum GFAP and IL-6 were lower and IL-10 higher in the LPV group. Lopinavir 69-72 interleukin 6 Homo sapiens 29-33 32580099-4 2020 The sustained release of the copper ions from Cu-EGCG was demonstrated in vitro, and biocompatible Cu-EGCG can scavenge intracellular ROS, reduce cell death in the presence of cytotoxic levels of ROS, and decrease the expression of pro-inflammatory cytokines (TNF-alpha, IL-6). cu-egcg 99-106 interleukin 6 Homo sapiens 271-275 32856282-11 2020 Increasing IL-6 levels affected darunavir concentration versus time simulated profiles. Darunavir 32-41 interleukin 6 Homo sapiens 11-15 33092789-5 2020 TAMs increase EZH2 stability by stimulating PRMT1-mediated meR342-EZH2 formation through the secretion of interleukin-6 (IL-6) cytokine. mer342 59-65 interleukin 6 Homo sapiens 121-125 32856282-12 2020 We hypothesized that increases in IL-6 levels associated with severe SARS-CoV-2 disease may downregulate the cytochrome P450 (CYP) 3A4-mediated metabolism of darunavir. Darunavir 158-167 interleukin 6 Homo sapiens 34-38 32022261-7 2020 RESULTS: Treatment with APG-157 resulted in circulating concentrations of curcumin and analogs peaking at 3 hours with reduced IL-1beta, IL-6, and IL-8 concentrations in the salivary supernatant fluid of patients with cancer. apg 24-27 interleukin 6 Homo sapiens 137-141 33490193-6 2020 The high level of IL-6 enhanced C2C12 myotube atrophy through the activation of JAK/STAT3, while inhibiting JAK/STAT3 pathway by ruxolitinib (a JAK1/2 inhibitor) or C188-9 (a STAT3 inhibitor) significantly attenuated C2C12 myotube atrophy induced by IL-6. C188-9 165-171 interleukin 6 Homo sapiens 18-22 32905367-2 2020 The present study aimed to explore the clinical efficacy of azithromycin combined with doxycycline in patients with NGU and its effect on serum levels of inflammatory cytokine interleukin-6 (IL-6). Azithromycin 60-72 interleukin 6 Homo sapiens 176-189 32905367-2 2020 The present study aimed to explore the clinical efficacy of azithromycin combined with doxycycline in patients with NGU and its effect on serum levels of inflammatory cytokine interleukin-6 (IL-6). Azithromycin 60-72 interleukin 6 Homo sapiens 191-195 32755990-8 2020 DHT pre-treatment inhibited LPS induced-mRNA expression of several pro-inflammatory mediators (i.e. COX2, IL6, IL12A and IFNgamma), effect significantly blunted by AR antagonist bicalutamide. Dihydrotestosterone 0-3 interleukin 6 Homo sapiens 106-109 33324265-5 2020 Results: The results showed that schizophrenia patients treated with olanzapine or clozapine (both MetS and non-MetS groups) had significantly higher plasma levels of IL-6, IL-10, and TNF-alpha compared to normal controls (all P < 0.05). Clozapine 83-92 interleukin 6 Homo sapiens 167-171 30961342-11 2020 After conventional therapy, levels of IL-6 (P=0.001) and IL-8 (P=0.001) significantly decreased in caffeine citrate prevention group compared with those in caffeine citrate treatment group. caffeine citrate 99-115 interleukin 6 Homo sapiens 38-42 32701561-0 2020 Icaritin inhibits lung cancer-induced osteoclastogenesis by suppressing the expression of IL-6 and TNF-a and through AMPK/mTOR signaling pathway. icaritin 0-8 interleukin 6 Homo sapiens 90-94 32489023-14 2020 Compared with the model control group, the high and low doses of Compound Qinlan Oral Liquid significantly reduced lung tissue viral load(P<0.01), increased cross blood CD4~+ T lymphocytes, CD8~+ T lymphocytes and total B lymphocyte percentage(P<0.01), reduced serum motilin content(P<0.01), reduced IL-6, IL-10, TNF-alpha and IFN-gamma levels in lungs(P<0.01) and reduced lung tissue inflammation. qinlan 74-80 interleukin 6 Homo sapiens 300-304 32538490-11 2020 There was a non-significant positive correlation between IL-6 levels and PROMs for xerostomia (r=0.31; p=0.06) and OHIP-14 (r=0.07; p=0.68) in pSS patients. ohip 115-119 interleukin 6 Homo sapiens 57-61 32975739-5 2021 After the intervention, the D-P group had between-group increases in mean change in the osteocalcin (P = 0.007) and IL-6 (P = 0.033), and decreases in the RBC (P < 0.001), Hb (P < 0.001), Hct (P < 0.001), and MCV (P = 0.001), compared with the D-Fe group. d-p 28-31 interleukin 6 Homo sapiens 116-120 33520867-13 2020 Conclusions: L-carnitine supplementation was associated with lowering of CRP, IL-6, TNF-alpha, and MDA, and increasing SOD levels, but did not affect other inflammatory and oxidative stress biomarkers. Carnitine 13-24 interleukin 6 Homo sapiens 78-82 32091090-6 2020 Additionally, naringin restored endothelial barrier integrity by preventing VE-cadherin disassembly and F-actin remodeling, and downregulated pro-inflammatory factors like IL-1beta, IL-6, and IL-18, in the HUVECs. naringin 14-22 interleukin 6 Homo sapiens 182-186 32701561-9 2020 Furthermore, ICT decreased the levels of IL-6 and TNF-alpha in osteoclasts, while the AMPK inhibitor compound C significantly abolished the inhibitory effects of ICT on IL-6 and TNF-alpha. icaritin 13-16 interleukin 6 Homo sapiens 41-45 32182743-7 2020 Macrophage interaction with CSnp-treated biofilm reduced proinflammatory markers (nitric oxide, TNF-alpha, IL-1beta, and IL-6), increased anti-inflammatory marker (TGF-beta1) and enhanced cell survival and spreading over time (p < 0.01 at 72 h). csnp 28-32 interleukin 6 Homo sapiens 121-125 32701561-9 2020 Furthermore, ICT decreased the levels of IL-6 and TNF-alpha in osteoclasts, while the AMPK inhibitor compound C significantly abolished the inhibitory effects of ICT on IL-6 and TNF-alpha. icaritin 162-165 interleukin 6 Homo sapiens 169-173 32042418-8 2020 On the other hand, the TNF-alpha-induced IL-6 secretion was attenuated by SAC and SAMC in a dose-dependent manner, whereas S1PC was ineffective. S-allylcysteine 74-77 interleukin 6 Homo sapiens 41-45 32963505-7 2020 Glycyrrhizin significantly prevented TNF-alpha-induced expression of HMGB1 (691.5 +- 136.4 vs 142.8 +- 57.3 pg/mL), IL-6 (388.1 +- 85.2 vs 189.4 +- 61.2 pg/mL) and IL-1beta (176.3 +- 47.2 vs 53.9 +- 25.7 pg/mL) in hPDLSC. Glycyrrhizic Acid 0-12 interleukin 6 Homo sapiens 116-120 33011534-0 2020 Novel tetrazole-based selective COX-2 inhibitors: Design, synthesis, anti-inflammatory activity, evaluation of PGE2, TNF-alpha, IL-6 and histopathological study. 1H-tetrazole 6-15 interleukin 6 Homo sapiens 128-132 32899782-0 2020 1,25-Dihydroxyvitamin D3 Inhibits Lipopolysaccharide-Induced Interleukin-6 Production by C2C12 Myotubes. Calcitriol 0-24 interleukin 6 Homo sapiens 61-74 32899782-9 2020 However, the IL-6 concentration was significantly lower in C2C12 myotubes following 1,25(OH)2D3 treatment than in C2C12 myotubes without 1,25(OH)2D3 treatment (p < 0.001). Calcitriol 84-95 interleukin 6 Homo sapiens 13-17 32899782-9 2020 However, the IL-6 concentration was significantly lower in C2C12 myotubes following 1,25(OH)2D3 treatment than in C2C12 myotubes without 1,25(OH)2D3 treatment (p < 0.001). ,25(oh)2d3 85-95 interleukin 6 Homo sapiens 13-17 32121312-6 2020 Risperidone and haloperidol both reduced the levels of IL-1alpha, IL-1beta, IL-2, and IL-17, and increased the levels of IL-6, IL-10, INF-gamma, and TNF-alpha. Risperidone 0-11 interleukin 6 Homo sapiens 121-125 32889778-10 2020 Icaritin treatment-induced dynamics of serum cytokines IL-6, IL-8, IL-10 and TNF-alpha, and soluble immune checkpoint proteins TIM3, LAG3, CD28, CD80, and CTLA-4 were assessed. icaritin 0-8 interleukin 6 Homo sapiens 55-59 32024920-0 2020 Author Correction: Novel Indole-fused benzo-oxazepines (IFBOs) inhibit invasion of hepatocellular carcinoma by targeting IL-6 mediated JAK2/STAT3 oncogenic signals. indole 25-31 interleukin 6 Homo sapiens 121-125 32899782-13 2020 1,25(OH)2D3 inhibited increases in IL-6 protein concentrations in muscle cells stimulated by LPS, suggesting that 1,25(OH)2D3 inhibits inflammation in muscle cells. Calcitriol 0-11 interleukin 6 Homo sapiens 35-39 32899782-13 2020 1,25(OH)2D3 inhibited increases in IL-6 protein concentrations in muscle cells stimulated by LPS, suggesting that 1,25(OH)2D3 inhibits inflammation in muscle cells. Calcitriol 114-125 interleukin 6 Homo sapiens 35-39 32899782-14 2020 The findings suggest that 1,25(OH)2D3 can prevent or improve sarcopenia, which is associated with IL-6. Calcitriol 26-37 interleukin 6 Homo sapiens 98-102 32461931-0 2020 Comparison of Efficacy between Clopidogrel and Ticagrelor in Patients with Acute Coronary Syndrome after Interventional Treatment and Their Effects on IL-6. Ticagrelor 47-57 interleukin 6 Homo sapiens 151-155 32759267-8 2020 ATV/RTV also impaired virus-induced enhancement of IL-6 and TNF-alpha levels. Atazanavir Sulfate 0-3 interleukin 6 Homo sapiens 51-55 32461931-1 2020 Background: We aimed to compare the efficacy between clopidogrel and ticagrelor in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI) and their effects on IL-6. Ticagrelor 69-79 interleukin 6 Homo sapiens 195-199 32759267-8 2020 ATV/RTV also impaired virus-induced enhancement of IL-6 and TNF-alpha levels. Ritonavir 4-7 interleukin 6 Homo sapiens 51-55 31651714-6 2020 In this study, we demonstrate that mangiferin interferes with inflammation, lipid and calcium signaling which selectively inhibits multiple NFkB target genes including interleukin-6, tumor necrosis factor, interferon gamma, vascular endothelial growth factor receptor 2, plasminogen activator urokinase, matrix metalloprotease 19, C-C Motif Chemokine Ligand 2 and placental growth factor. mangiferin 35-45 interleukin 6 Homo sapiens 168-181 32874136-8 2020 Additionally, in both the rabbit trauma model and cellular injury model, CAA combined with high-dosage of VB6 inhibited the expression of inflammatory factors (IL-6, TNF-alpha and IL-1beta) and proteins (HMGB1, TLR4 and p-p65) in HMGB1/TLR4/NF-kappaB pathway. caa 73-76 interleukin 6 Homo sapiens 160-164 32634441-8 2020 We found that COB-187 significantly reduced, at the protein and mRNA levels, cytokines induced by LPS (e.g. IL-6, TNF-alpha, IL-1beta, CXCL10, and IFN-beta). cob-187 14-21 interleukin 6 Homo sapiens 108-112 32417162-8 2020 Our results showed that STA significantly suppressed IL-1beta-induced inflammation with decreased levels of inflammatory mediators and cytokines including NO, PGE2, iNOS, COX-2, TNF-alpha and IL-6. stachydrine 24-27 interleukin 6 Homo sapiens 192-196 31106659-5 2020 In addition, serum level of IL-6 was decreased significantly in omega-3, vitamin D3, and cosupplementation groups compared with baseline. Cholecalciferol 73-83 interleukin 6 Homo sapiens 28-32 32828308-6 2020 Subsequentially, it demethylated N6-methyladenosine (m6A) modification of IL6 mRNA and inhibited its nuclear export. N-methyladenosine 33-51 interleukin 6 Homo sapiens 74-77 31777561-8 2019 TPL also decreased the TGF-beta1-induced production of IL-6 and reduced the upregulation of ColIalpha, ColIII, FAK, p-FAK, and inhibited the decrease of calpain 1 and calpain 2 induced by TGF-beta1. triptolide 0-3 interleukin 6 Homo sapiens 55-59 31777561-9 2019 In addition, the FAK inhibitor acted synergistically with TPL to decrease TGF-beta1-induced production of IL-6 and attenuate TGF-beta1-induced synthesis of ColIalpha and ColIII, while calpeptin had an antagonistic effect on the function of TPL. triptolide 58-61 interleukin 6 Homo sapiens 106-110 32534189-4 2020 In vitro studies have demonstrated the capacity of azithromycin in reducing production of pro-inflammatory cytokines such as IL-8, IL-6, TNF alpha, reduce oxidative stress, and modulate T-helper functions. Azithromycin 51-63 interleukin 6 Homo sapiens 131-135 32461554-8 2020 Colchicine decreased concentrations of multiple inflammatory molecules, including C-reactive protein, interleukin 6, and resistin, in addition to vascular-related proteins (e.g., oxidized low-density lipoprotein receptor, phosphodiesterase 5A). Colchicine 0-10 interleukin 6 Homo sapiens 102-115 32828308-6 2020 Subsequentially, it demethylated N6-methyladenosine (m6A) modification of IL6 mRNA and inhibited its nuclear export. N-methyladenosine 53-56 interleukin 6 Homo sapiens 74-77 32461554-11 2020 Further research is warranted to investigate whether colchicine"s IL-6 suppressive effects may be beneficial in COVID-19. Colchicine 53-63 interleukin 6 Homo sapiens 66-70 32922141-7 2020 Treatment with cinnamaldehyde, tadalafil, or aliskiren reduced serum levels of rheumatoid factor, and pro-inflammatory cytokines; tumor necrosis factor-alpha and interleukin-6 (IL-6), along with elevated level of IL-10 which is an anti-inflammatory cytokine. aliskiren 45-54 interleukin 6 Homo sapiens 162-175 32765941-5 2020 Since PGE2, LXA4 and their precursors AA (arachidonic acid), dihomo-gamma-linolenic acid (DGLA) and gamma-linolenic acid (GLA) inhibit the production of pro-inflammatory IL-6 and TNF-alpha, they could be employed to treat cytokine storm seen in COVID-19, immune check point inhibitory (ICI) therapy, sepsis and ARDS (acute respiratory disease). 8,11,14-Eicosatrienoic Acid 61-88 interleukin 6 Homo sapiens 170-174 32765941-5 2020 Since PGE2, LXA4 and their precursors AA (arachidonic acid), dihomo-gamma-linolenic acid (DGLA) and gamma-linolenic acid (GLA) inhibit the production of pro-inflammatory IL-6 and TNF-alpha, they could be employed to treat cytokine storm seen in COVID-19, immune check point inhibitory (ICI) therapy, sepsis and ARDS (acute respiratory disease). 8,11,14-Eicosatrienoic Acid 90-94 interleukin 6 Homo sapiens 170-174 32500755-0 2021 Naringin inhibits titanium particles-induced up-regulation of TNF-alpha and IL-6 via the p38 MAPK pathway in fibroblasts from hip periprosthetic membrane. naringin 0-8 interleukin 6 Homo sapiens 76-80 32500755-9 2021 RESULTS: Naringin or SB203580 pretreatment significantly suppressed the secretion of TNF-alpha and IL-6 induced by titanium particles in fibroblasts, while inhibition of ERK or JNK pathways showed no effect on production of TNF-alpha and IL-6. naringin 9-17 interleukin 6 Homo sapiens 99-103 32500755-9 2021 RESULTS: Naringin or SB203580 pretreatment significantly suppressed the secretion of TNF-alpha and IL-6 induced by titanium particles in fibroblasts, while inhibition of ERK or JNK pathways showed no effect on production of TNF-alpha and IL-6. naringin 9-17 interleukin 6 Homo sapiens 238-242 31668400-10 2019 In addition, lactoferrin reduced gene expression of IL-6, while it increased gene expression of Lgr5 and Wnt/beta-catenin. ITLN1 protein, human 13-24 interleukin 6 Homo sapiens 52-56 31738650-5 2021 When these LPS + LBP-stimulated cells were exposed to DHT for 2 days, it was found that DHT suppressed the secretion of IL-6, IL-10, IL-1beta, VEGF-A cytokines in corneal epithelial cells; TNF-alpha, IL-6, IL-1beta, VEGF-A cytokines in conjunctival epithelial cells; and IL-6, IL-1beta, VEGF-A cytokines in meibomian gland epithelial cells.Conclusion: LPS + LBP is shown to induce the secretion of certain proinflammatory cytokines from ocular surface and adnexal epithelial cells. Dihydrotestosterone 88-91 interleukin 6 Homo sapiens 120-124 31466050-10 2019 Moreover, genipin pretreatment alleviated LPS-induced inflammation, indicating by blockade of nuclear factor kappa b (NF-kappaB) signaling activation and reduced tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1beta, and IL-6 levels in the lung and bronchoalveolar lavage fluid. genipin 10-17 interleukin 6 Homo sapiens 231-235 32922141-7 2020 Treatment with cinnamaldehyde, tadalafil, or aliskiren reduced serum levels of rheumatoid factor, and pro-inflammatory cytokines; tumor necrosis factor-alpha and interleukin-6 (IL-6), along with elevated level of IL-10 which is an anti-inflammatory cytokine. aliskiren 45-54 interleukin 6 Homo sapiens 177-181 32560222-12 2020 Notably, an increased level of the tumor suppressor, miR-142-3p, whose targets include LGR5, IL-6, and ABCG2, was detected in association with MSI-N1014 treatment. mir-142-3p 53-63 interleukin 6 Homo sapiens 93-97 32922141-12 2020 Collectively, these findings led to the assumption that the downregulation of IL-6/JAK2/STAT3 signaling by cinnamaldehyde, tadalafil, and aliskiren could alleviate joint destruction by MMP-3 and RANKL, reduce iNOS, and enhance eNOS expressions. cinnamaldehyde 107-121 interleukin 6 Homo sapiens 78-82 32922141-12 2020 Collectively, these findings led to the assumption that the downregulation of IL-6/JAK2/STAT3 signaling by cinnamaldehyde, tadalafil, and aliskiren could alleviate joint destruction by MMP-3 and RANKL, reduce iNOS, and enhance eNOS expressions. aliskiren 138-147 interleukin 6 Homo sapiens 78-82 32223462-2 2020 Positive effects of drug beta-d-mannuronic acid (M2000) were proven on their expression in the HEK-Blue hTLR2 cell line, and results of its phase III clinical trial on RA patients were encouraging.Objective: This research aimed to investigate the effects of M2000 on expression of these genes and serum levels of IL-6 and TNF-alpha as pro-inflammatory cytokines in RA patients.Material and methods: In this study (Trial Registration Number: IRCT2017100213739N10), 12 RA patients (according to the American College of Rheumatology criteria) and 12 healthy subjects (as control group) were selected. mannuronic acid 25-47 interleukin 6 Homo sapiens 313-317 31741772-11 2019 TAM-derived IL-6 could be a potential therapeutic target for peritoneal dissemination of GC. TAM protocol 0-3 interleukin 6 Homo sapiens 12-16 32531710-7 2020 C-BF and NFN treatment decreased (P < 0.05) IL-6, IL-8, IL-22, IL-10 and transforming growth factor-beta (TGF-beta) production in the jejunum and ileum compared with the control group. nfn 9-12 interleukin 6 Homo sapiens 44-48 31795791-13 2020 The present study demonstrates that serum HIF-1alpha, hepcidin and IL-6 levels were significantly higher in TPD group than uncomplicated group. N,N'-Bis(3-methylphenyl)-N,N'-bis(phenyl)benzidine 108-111 interleukin 6 Homo sapiens 67-71 30874442-5 2019 Key contributions from COPDGene include identification of DNA methylation effects from smoking and genetic variation, new transcriptomic signatures in the blood, identification of protein biomarkers associated with severity and progression (e.g., sRAGE [soluble receptor for advanced glycosylation end products], inflammatory cytokines IL-6 and IL-8), and identification of small molecules (ceramides and sphingomyelin) that may be pathogenic. copdgene 23-31 interleukin 6 Homo sapiens 336-340 32219875-9 2020 Cocultivation of pDCs and B cells increased the RNA-IC-stimulated IFN-alpha and TNF levels, while only IL-6 production was enhanced in the DSR-6434-stimulated cocultures. dsr 139-142 interleukin 6 Homo sapiens 103-107 32711743-4 2020 RESULTS: In analyses adjusted for age and sex, each log-unit greater IL-6 was significantly associated in the Pulmonary Arterial Hypertension Biobank cohort with greater pulmonary vascular resistance indices, lower odds of having idiopathic PAH or treatment with prostacyclin, and greater odds of having PAH associated with a repaired congenital shunt. Epoprostenol 263-275 interleukin 6 Homo sapiens 69-73 31897949-6 2020 Also, the patients receiving vitamin D3 yielded a marginally significant lower IL-6 serum concentration (76.43 ng/L) compared to placebo (93.10 ng/L) (P value:0.055). Cholecalciferol 29-39 interleukin 6 Homo sapiens 79-83 31450894-0 2019 IL-6 Impairs the Activity of Vitamin D3 in the Regulation of Epithelial-Mesenchymal Transition in Triple Negative Breast Cancer. Cholecalciferol 29-39 interleukin 6 Homo sapiens 0-4 31450894-12 2019 Conclusion: The presence of IL-6 in the breast tumor microenvironment may impair theactivity of vitamin D3 signaling, limiting its anti-tumor effects in TNBC. Cholecalciferol 96-106 interleukin 6 Homo sapiens 28-32 32060401-2 2020 MEDI2228, more effectively than its anti-tubulin MMAF-ADC homolog, induces cytotoxicity against MM cells regardless of drug resistance, BCMA levels, p53 status, and the protection conferred by bone marrow stromal cells and IL-6. medi2228 0-8 interleukin 6 Homo sapiens 223-227 30919933-7 2019 High levels of D-fructose compared to D-glucose led to activation of DCs in vitro by promoting interleukin (IL)-6 and IL-1beta production. Fructose 15-25 interleukin 6 Homo sapiens 95-113 31085401-3 2019 Herein, a highly sensitive and selective aptasensor for quantitative detection of interleukin-6 was developed by using a glassy carbon electrode modified with p-aminobenzoic acid, p-aminothiophenol and gold nanoparticles. 4-aminothiophenol 180-197 interleukin 6 Homo sapiens 82-95 32057949-10 2020 Furthermore, silencing of AL049437 alleviated MPP+-induced neuroinflammation and oxidative stress, as indicated by the reduction in tumor necrosis factor-alpha and interleukin-6 levels and reactive oxygen species production. Ephrin-A5 26-34 interleukin 6 Homo sapiens 164-177 32004600-3 2020 In the present study, we generated the active-targeted hyaluronate (HA) recoated N, N, N-trimethyl chitosan (TMC) nanoparticles (NPs) to deliver IL-6- and STAT3-specific small interfering RNAs (siRNAs) to the CD44-expressing cancer cells. Choline 87-98 interleukin 6 Homo sapiens 145-149 32251441-1 2020 BACKGROUND & AIMS: In our previous study, a Seesaw model was proposed for the fluctuation of crucial anti- (IL-10) and pro-inflammatory (Il-6 & IL-17A) cytokines through vitamin D3. Cholecalciferol 170-180 interleukin 6 Homo sapiens 137-141 31085401-4 2019 A thio-terminated aptamer specific for interleukin-6 was immobilized on the surface of the modified electrode via the formation of gold-sulfur bonds. thio 2-6 interleukin 6 Homo sapiens 39-52 32714547-12 2020 In contrast, IL-6 at 24 h was significantly lower in the ketamine group compared with the control group (mean difference, -7.3 pg ml-1; 95% confidence interval, -14.4 to -0.2; P=0.04). Ketamine 57-65 interleukin 6 Homo sapiens 13-17 30895589-11 2019 Apart from a massive airway inflammation indicated by elevated numbers of total cells and neutrophils, the CBA analysis showed increased levels of IL-6 and IL-8 (p < 0.01). cba 107-110 interleukin 6 Homo sapiens 147-151 31212975-9 2019 U0126 and SB202190 could inhibit the expression of IL-6, IL-8 and MCP-1, but SP600125 could not. U 0126 0-5 interleukin 6 Homo sapiens 51-55 32251441-7 2020 In addition, the plasma levels of IL-27, TGF-beta1, IL-10, IL-17A, and IL-6 significantly changed following the administration of vitamin D3. Cholecalciferol 130-140 interleukin 6 Homo sapiens 71-75 32295417-7 2020 Among 280 PCI subjects in a nested inflammatory biomarker substudy, the primary biomarker end point, change in interleukin-6 concentrations did not differ between groups 1-hour post-PCI but increased less 24 hours post-PCI in the colchicine (n=141) versus placebo group (n=139; 76% [-6 to 898] versus 338% [27 to 1264], P=0.02). Colchicine 230-240 interleukin 6 Homo sapiens 111-124 32295417-9 2020 CONCLUSIONS: Acute preprocedural administration of colchicine attenuated the increase in interleukin-6 and high-sensitivity C-reactive protein concentrations after PCI when compared with placebo but did not lower the risk of PCI-related myocardial injury. Colchicine 51-61 interleukin 6 Homo sapiens 89-102 31231214-6 2019 Moreover, immunohistochemistry and enzyme-linked immunosorbent assays showed that DAC reduced the release of tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-6 in vivo. deacylcynaropicrin 82-85 interleukin 6 Homo sapiens 166-170 31927051-8 2020 The result showed that nifedipine inhibited the expression of matrix metalloprotein(MMP)-13, interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha, cyclooxygenase (COX)-2, inducible nitric oxide (NO) synthase (iNOS), and prostaglandin E2 (PGE2), as well as reduced ROS production in human OA chondrocytes, which was partially reversed by BR. Nifedipine 23-33 interleukin 6 Homo sapiens 117-121 31165299-12 2019 The anti-IL-6 receptor tocilizumab was, therefore, administered with a rapid improvement of her active psoriatic arthritis that remained dependent on low prednisone dosage. Prednisone 154-164 interleukin 6 Homo sapiens 9-13 30615197-8 2019 Together, these data demonstrate that these novel small molecule IL-6 inhibitors have the potential to shift the Teff : Treg balance, which may provide a novel therapeutic strategy for ameliorating disease progression in MS. teff 113-117 interleukin 6 Homo sapiens 65-69 32004536-5 2020 In addition, measurements of blood cytokine levels after repeat injection indicate that reduced levels of inflammatory cytokines (IL-6, IFN-gamma,TNFalpha) are elicited in response to lipoplexes coated with lactose as compared to PEG. Lactose 207-214 interleukin 6 Homo sapiens 130-134 32256716-2 2020 Aim: The aim of this research was to investigate the effect of 6-week aerobic exercise with moderate intensity and consumption of nano-curcumin on IL-6, IL-10 and BDNF in 60-65 year females with metabolic syndrome (MS). nano-curcumin 130-143 interleukin 6 Homo sapiens 147-151 32648126-9 2022 Furthermore, 48-h treatment with KAI decreased the phosphorylation level of STAT3, inhibited the mRNA and protein expressions of IL-6 (all P<0.01). Kainic Acid 33-36 interleukin 6 Homo sapiens 129-133 32308723-7 2020 However, all of 5 selected polysaccharides significantly (P < 0.05) decreased proinflammatory (IL-1beta + IL-6 + TNF-alpha)/anti-inflammatory (IL-10) cytokine secretion ratios by LPS-stimulated macrophages, exhibiting that all of the 5 selected polysaccharides, particularly GSPS, have anti-inflammatory potential. Polysaccharides 27-42 interleukin 6 Homo sapiens 106-110 30835899-4 2019 Treatment with iron (ferric ammonium citrate, FAC) led to increased expression levels of M1 markers: CCL2, CD14, iNOS, IL-1beta, IL-6, and TNF-alpha; it also increased protein levels of CD68, TNF-alpha, IL-1beta, and IL-6 by flow cytometry. ferric ammonium citrate 21-44 interleukin 6 Homo sapiens 129-133 30835899-4 2019 Treatment with iron (ferric ammonium citrate, FAC) led to increased expression levels of M1 markers: CCL2, CD14, iNOS, IL-1beta, IL-6, and TNF-alpha; it also increased protein levels of CD68, TNF-alpha, IL-1beta, and IL-6 by flow cytometry. ferric ammonium citrate 21-44 interleukin 6 Homo sapiens 217-221 32314492-0 2020 Doxycycline, a widely used antibiotic in dermatology with a possible anti-inflammatory action against IL-6 in COVID-19 outbreak. Doxycycline 0-11 interleukin 6 Homo sapiens 102-106 30992036-4 2019 RESULTS: On multivariate logistic regression analysis adjusted for age and gender, predictors of high H3Cit (>= 7.36 ng/mL, upper quartile) were: glycated hemoglobin (HbA1c) >= 7.0% and interleukin-6. Citric Acid 102-107 interleukin 6 Homo sapiens 192-205 32192288-9 2020 Conclusion: Serum T-25 (OH) D level was negatively correlated with CDAI, serum IL-6 level and inflammatory markers in patients with CD, and it was lower in active CD patients with infection than those without infection. t-25 (oh) d 18-29 interleukin 6 Homo sapiens 79-83 31648047-5 2020 We found that rifampicin pretreatment suppressed the gene expression of IL-1beta and IL-6 via inhibiting activation of JNK after rotenone induction, but the anti-inflammatory effect of rifampicin was reversed by chloroquine. Rifampin 14-24 interleukin 6 Homo sapiens 85-89 32706089-6 2020 Pentoxifylline, a non-specific phosphodiesterase inhibitor widely used to improve the rheological properties of blood, has beneficial anti-inflammatory properties and can significantly reduce the serum levels of pro-inflammatory cytokines such as interleukin (IL)-6, IL-1, tumour necrosis factor-alpha, C-reactive protein and other immunoregulators. Pentoxifylline 0-14 interleukin 6 Homo sapiens 247-265 31887898-2 2020 The results demonstrated that, at high concentrations, carrageenans have substantial ability to modulate PGE2 synthesis and stimulate IL-1beta and IL-6 synthesis. Carrageenan 55-67 interleukin 6 Homo sapiens 147-151 30110560-9 2019 Collectively, our study reveals that miR-204-5p inhibits the inflammation and chemokine generation in renal tubular epithelial cells by modulating the IL6/IL6R axis. mir-204-5p 37-47 interleukin 6 Homo sapiens 151-154 30647133-7 2019 Pregnenolone and its metabolites suppressed the secretion of tumor necrosis factor alpha and interleukin-6 mediated through TLR2 and TLR4 signaling. Pregnenolone 0-12 interleukin 6 Homo sapiens 93-106 32416450-6 2020 BCP exhibited anti-inflammatory activity with decreased levels of TNF-alpha, IL-1beta, IL-6 in HG-induced MCs. caryophyllene 0-3 interleukin 6 Homo sapiens 87-91 30690246-7 2019 The increase of IL-6 showed a statistically significant correlation with myristic acid, to a lesser extent with cis-9-eicosenoic acid and to the least extent with docosahexaenoic acid, inversely with pentadecanoic, gamma-linolenic and stearic acids. pentadecanoic 200-213 interleukin 6 Homo sapiens 16-20 30690246-7 2019 The increase of IL-6 showed a statistically significant correlation with myristic acid, to a lesser extent with cis-9-eicosenoic acid and to the least extent with docosahexaenoic acid, inversely with pentadecanoic, gamma-linolenic and stearic acids. gamma-linolenic 215-230 interleukin 6 Homo sapiens 16-20 30690246-7 2019 The increase of IL-6 showed a statistically significant correlation with myristic acid, to a lesser extent with cis-9-eicosenoic acid and to the least extent with docosahexaenoic acid, inversely with pentadecanoic, gamma-linolenic and stearic acids. Stearic Acids 235-248 interleukin 6 Homo sapiens 16-20 30887238-1 2019 A physiologically based pharmacokinetic (PBPK) model was used to simulate the impact of elevated levels of interleukin (IL)-6 on the exposure of several orally administered cytochrome P450 (CYP) probe substrates (caffeine, S-warfarin, omeprazole, dextromethorphan, midazolam, and simvastatin). Caffeine 213-221 interleukin 6 Homo sapiens 107-125 30918802-7 2019 The concentrations of IL-6, IL-8 and MCP-1 in the culture medium reduced to 66% (for IL-6 and MCP-1) and 56% (for IL-8) of the levels without zeaxanthin. Zeaxanthins 142-152 interleukin 6 Homo sapiens 22-26 32015381-5 2020 The results of the in vitro examination revealed a significant decrease in TER in the group treated with IL-6 alone compared with the placebo-vehicle group (p < 0.05) and the group treated with IL-6 and rebamipide (p < 0.01). rebamipide 203-213 interleukin 6 Homo sapiens 105-109 31680128-5 2020 RESULTS: Fipronil treatment increased pro-inflammatory cytokine interleukin (IL)-1beta, IL-6, IL-8, and MUC5AC expression in human primary nasal epithelial cells. fipronil 9-17 interleukin 6 Homo sapiens 88-92 31680128-9 2020 CONCLUSIONS: Fipronil induced pro-inflammatory cytokine IL-1beta, IL-6, IL-8, and MUC5AC expression via ERK1/2 MAPK, p38 MAPK, and NF-kB in human primary nasal epithelial cells. fipronil 13-21 interleukin 6 Homo sapiens 66-70 32569211-4 2020 Meanwhile, MIR103 and MIR107 were negatively correlated with acute pathologic and chronic health evaluation (APACHE) II score, sequential organ failure assessment (SOFA) score, serum creatinine, C-reactive protein, tumor necrosis factor, interleukin 1beta, interleukin 6 and interleukin 8, while positively correlated with albumin in sepsis patients. mir103 11-17 interleukin 6 Homo sapiens 257-270 32144909-14 2020 Compared with the FTS group, the level of CRP on 3 d and the levels of N, CRP, IL-6 on 6 d in the FTS+LEAS group were significantly decreased (P<0.05). leas 102-106 interleukin 6 Homo sapiens 79-83 32203968-0 2020 Vitamin D3 Supplementation in Diarrhea-Predominant Irritable Bowel Syndrome Patients: The Effects on Symptoms Improvement, Serum Corticotropin-Releasing Hormone, and Interleukin-6 - A Randomized Clinical Trial. Cholecalciferol 0-10 interleukin 6 Homo sapiens 166-179 30838176-8 2019 In line with these results, ERK (U0126) and p38 MAPK (SB203580) specific signaling inhibitors suppressed hIL-6 expression and attenuated cell growth in PEL cells. U 0126 33-38 interleukin 6 Homo sapiens 105-110 32560222-9 2020 MSI-N1014 treatment led to decreased expressions of oncogenic markers, including mammalian target of rapamycin (mTOR), EGFR, and IL-6 and stemness markers such as CD44, beta-catenin, and LGR5. msi-n1014 0-9 interleukin 6 Homo sapiens 129-133 30357602-4 2019 After 72 h of incubation of PBMCs from eRA patients with 1,25(OH)2D3, the levels of IFN- , TNF-alpha, IL-2, IL-6, and IL-17 significantly decreased compared to those of the control. Calcitriol 57-68 interleukin 6 Homo sapiens 108-112 32203968-12 2020 CONCLUSION: Our findings indicate that vitamin D3 supplementation can modulate the serum level of CRH and IL-6 and can improve symptoms in IBS-D patients. Cholecalciferol 39-49 interleukin 6 Homo sapiens 106-110 32560222-10 2020 More importantly, MSI-N1014 treatment suppressed the transformation of CAFs, and was associated with decreased secretion of IL-6 and vascular endothelial growth factor (VEGF) by CAFs. msi-n1014 18-27 interleukin 6 Homo sapiens 124-128 30357602-9 2019 The present study demonstrated that 1,25(OH)2D3 inhibited the synthesis of specific cytokines: Th1 (IFN- ) and Th17 (IL-17, IL-22, IL-6, TNF-alpha) might upregulated Th2 cytokine (IL-4), which indicated the possible immunoregulatory roles and bone-sparing effects of 1,25(OH)2D3 in eRA through modulation of the Th1 and Th17 cytokine balance. Calcitriol 36-47 interleukin 6 Homo sapiens 131-135 32582685-9 2020 Notably, the increase in interleukin 6 (IL6) protein, as well as the increase in mir-125b (that targets IL6 receptor) was especially relevant. mir-125b 81-89 interleukin 6 Homo sapiens 104-107 30811143-5 2019 More importantly, when compared with another direct AR antagonist, enzalutamide, clascoterone was significantly better at inhibiting IL-6 synthesis from DHT-stimulated primary cultures of human scalp DPC. Dihydrotestosterone 153-156 interleukin 6 Homo sapiens 133-137 32406319-10 2020 The level of interleukin 6 was reduced in desloratadine-treated cells, while upregulation of interleukin 6 significantly abolished the anticancer activity of desloratadine in cell invasion and Bcl-2, Bax, Beclin1, LC3-I/II, N-cadherin, and E-cadherin expression in EJ cells. desloratadine 42-55 interleukin 6 Homo sapiens 13-26 32406319-10 2020 The level of interleukin 6 was reduced in desloratadine-treated cells, while upregulation of interleukin 6 significantly abolished the anticancer activity of desloratadine in cell invasion and Bcl-2, Bax, Beclin1, LC3-I/II, N-cadherin, and E-cadherin expression in EJ cells. desloratadine 158-171 interleukin 6 Homo sapiens 93-106 32406319-11 2020 Taken together, our data suggest a potential anticancer activity of desloratadine on cell growth and invasion for bladder cancer, which may be mediated by diminishing the epithelial-to-mesenchymal transition and interleukin 6. desloratadine 68-81 interleukin 6 Homo sapiens 212-225 32582685-10 2020 These results suggest a potential involvement of EV-CDCs in the regulation of the IL6/IL6R axis, with implications in inflammatory-mediated diseases. Chenodeoxycholate 3-sulphate 52-56 interleukin 6 Homo sapiens 82-85 31949464-11 2019 Granule of BU-XIN RUAN-MAI significantly improved oxidation stress by increasing PPARalpha expression, and it inhibited inflammation by downregulating expression and contents of IL-6, IL-1beta, and TNF-alpha. poly-5-bromouridylic acid 11-22 interleukin 6 Homo sapiens 178-182 32503178-6 2020 Fermentation of media supplemented with native and enzyme-treated oat beta-glucans increased the relative abundance of Enterococcus and attenuated pro-inflammatory cytokine production (IL-1beta, IL-6, TNFalpha) in immature dendritic cells. beta-Glucans 70-82 interleukin 6 Homo sapiens 195-199 31852517-13 2019 The gamma-hexalactone only at 5.15 muM induced increase in the levels of IL-6 (~ 60%), TNF-alpha (~ 68%) and IFN-gamma (~ 29%), but decreased IL-10 (~ 46%) in comparison with the negative control (p < 0.05). 4-hexanolide 4-21 interleukin 6 Homo sapiens 73-77 30551507-4 2019 The results suggested that ACY-1215 can markedly suppress the expression of inflammatory factors, including IL-1beta and IL-6 in human primary chondrocytes and C28/I2 cells. ricolinostat 27-35 interleukin 6 Homo sapiens 121-125 28967799-7 2019 Interleukin (IL)-6 was increased by caffeinated coffee compared with placebo in one of four coffee trials, and by caffeine in three out of five studies. Caffeine 114-122 interleukin 6 Homo sapiens 0-18 32199223-6 2020 Pretreatment of THP-1 monocytes with DHA effectively inhibited Abeta-induced activation and markedly suppressed protein expression of necroptosis (RIPK1, RIPK3, MLKL) and pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6). Docosahexaenoic Acids 37-40 interleukin 6 Homo sapiens 220-224 30273577-8 2019 The involvement of sphingolipids in the cooperative stimulation by palmitate and LPS on cytokine expression was indicated by the findings that the inhibitor of CER de novo synthesis or SM hydrolysis attenuated the stimulation of IL-6 expression by palmitate and LPS. Sphingolipids 19-32 interleukin 6 Homo sapiens 229-233 30507116-8 2018 The benzopyrene directionally led the bronchial epithelium to present observable cell shrinkage, cytoskeleton disintegration, Caspase-3 activation, overproduction of reactive oxygen species, and various inflammatory cytokine (TNF-alpha, IL-6, and IL-8) secretion, suggesting its significant inflammatory and cytotoxic effects on respiratory system. Benzopyrenes 4-15 interleukin 6 Homo sapiens 237-241 30369518-15 2018 And we found that 786-O RCC cells secrete high IL-6 levels after low dose stimulation with the TKIs sorafenib, sunitinib and pazopanib, inducing activation of AKT-mTOR pathway, NFkappaB, HIF-2alpha and VEGF expression. Sunitinib 111-120 interleukin 6 Homo sapiens 47-51 31811113-4 2019 RESULTS Cells predisposed to MG demonstrated an increase in oxidative stress with augmented (P<0.01) inflammatory cytokines such as cyclooxygenase (COX)-2, chemokine receptor CXCR4, interleukin (IL)-6, IL-8, monocyte chemoattractant protein-1 (MCP-1), and intercellular adhesion molecule 1 (ICAM-1) genes. Pyruvaldehyde 29-31 interleukin 6 Homo sapiens 185-203 31791385-12 2019 Treatment of GBM cells with MC4040 and MC4041 also impaired the GBM pro-inflammatory phenotype, with a significant decrease of TGF-beta, TNF-alpha, and IL-6, joined to an increase of the anti-inflammatory cytokine IL-10. antibiotic complex 4041 39-45 interleukin 6 Homo sapiens 152-156 30942641-10 2019 Our results indicate that saxagliptin significantly inhibited LPS-induced expression and secretions of tumour necrosis factor alpha (TNF-alpha), interleukin (IL)-1beta and IL-6 in HDPCs. saxagliptin 26-37 interleukin 6 Homo sapiens 172-176 32248516-14 2020 The new sesquiterpene was evaluated for the luciferase assay on 14 main cancer-related signaling pathways and showed selective inhibition of STAT3/IL6, and Smad/ TGF-beta transcription factors. Sesquiterpenes 8-21 interleukin 6 Homo sapiens 147-150 31730488-11 2019 Conditioned medium of IPTD-MSCs treated with a combination of DMOG and TNF-alpha contained higher levels of pro-angiogenic (VEGF, IL-6, and IL-8) compared to controls, promoting angiogenesis of human endothelial cells in vitro. Glyprothiazol 22-26 interleukin 6 Homo sapiens 130-134 30627059-11 2018 In face of lipopolysaccharide (LPS) stimulation, Primovist , Omniscan , and Magnevist groups exhibited elevated nitrite/nitrate and suppressed IL-1beta secretion and IL-6 and IL-10 secretion. gadodiamide 61-69 interleukin 6 Homo sapiens 167-171 30272289-12 2018 In addition, pretreatment with TCSGs inhibited the NF-kappaB signaling pathway by blocking the degradation of the inhibitor of nuclear factor kappaBalpha (IkappaBalpha), thereby reducing the expression and nuclear translocation of NF-kappaB, as well as reducing the expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2). tcsgs 31-36 interleukin 6 Homo sapiens 321-334 30272289-12 2018 In addition, pretreatment with TCSGs inhibited the NF-kappaB signaling pathway by blocking the degradation of the inhibitor of nuclear factor kappaBalpha (IkappaBalpha), thereby reducing the expression and nuclear translocation of NF-kappaB, as well as reducing the expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2). tcsgs 31-36 interleukin 6 Homo sapiens 336-340 31708994-9 2019 Treatment of senescent SF with the senolytic drug fenofibrate normalized IL6, CXCL8 and CCL2 mRNA expression. Fenofibrate 50-61 interleukin 6 Homo sapiens 73-76 31129702-10 2020 HCY and vitamin B6 correlated with age-corrected RTL (r = - 0.086, p < 0.001; r = 0.04, p = 0.031, respectively), IL-6 (r = 0.148, p < 0.001; r = - 0.249, p < 0.001, respectively), and hs-CRP (r = 0.101, p < 0.001; r = - 0.320, p < 0.001, respectively). Homocysteine 0-3 interleukin 6 Homo sapiens 117-121 32251963-5 2020 OA-DHZ was found to inhibit the carrageenan-induced edema and leukocyte migration, acetic acid-induced increase in vascular permeability and lipopolysaccharide-induced pro-inflammatory cytokines like TNF-alpha, IL-6, and IL-1beta. Acetic Acid 83-94 interleukin 6 Homo sapiens 211-215 31545873-6 2019 In addition, in serum and brain tissue, GA also dramatically inhibited the secretion of inflammatory cytokines, including interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha. Glycyrrhizic Acid 40-42 interleukin 6 Homo sapiens 152-189 30221352-11 2018 Sr2+ reversed LPS-stimulated proinflammatory cytokine expressions such as tumor necrosis factor alpha, interleukin (IL)-1beta, IL-6 and IL-8. strontium cation 0-4 interleukin 6 Homo sapiens 127-131 30144574-6 2018 Our results suggest an immunostimulatory role for the iodine substituted ZnPc on macrophages based on the changes in pro-inflammatory cytokine production levels (TNFalpha, IL1beta and IL6). zinc(II) phthalocyanine trisulfonic acid 73-77 interleukin 6 Homo sapiens 184-187 32037273-11 2020 Methylprednisolone reduced the proinflammatory cytokines interleukin-6 and interleukin-8 and increased the anti-inflammatory cytokine interleukin-10 postoperatively. Methylprednisolone 0-18 interleukin 6 Homo sapiens 57-70 30485517-10 2018 The production of inflammatory cytokines, including tumor necrosis factor alpha, interleukin (IL)- 6, and IL-8, was reduced by carvacrol in LPS-induced RA-FLSs. carvacrol 127-136 interleukin 6 Homo sapiens 81-100 31408726-8 2019 Furthermore, exposure of primary human monocyte-derived DCs (moDC) to 8-oxoG base resulted in significantly enhanced expression of cell surface molecules (CD40, CD86, CD83, HLA-DQ) and augmented the secretion of pro-inflammatory mediators IL-6, TNF and IL-8, whereas it did not considerably influence the production of the anti-inflammatory cytokine IL-10. 8-oxog base 70-81 interleukin 6 Homo sapiens 239-243 32356241-0 2020 Synthetic antiprotozoal thiazolide drug induced apoptosis in colorectal cancer cells: implications of IL-6/JAK2/STAT3 and p53/caspases-dependent signaling pathways based on molecular docking and in vitro study. thiazolide 24-34 interleukin 6 Homo sapiens 102-106 30975599-9 2019 IL-6 levels were higher in patients with a Clavien-Dindo >= III complication (634[309-1489] vs. 297 [171-680], p = 0.034) and POPF grade B/C (994 [534-3265] vs. 334 [173-704], p = 0.003). clavien-dindo > 43-60 interleukin 6 Homo sapiens 0-4 31553934-7 2019 CBDV attenuates, in a TRPA1-antagonist sensitive manner, DNBS-induced signs of inflammation including neutrophil infiltration, intestinal permeability, and cytokine (i.e. IL-1beta, IL-6 and the chemokine MCP-1) production. dinitrobenzenesulfonic acid 57-61 interleukin 6 Homo sapiens 181-185 30533524-5 2018 Results: Vitamin D3 affected the levels of IL-17A, IL-10, and IL-6 among the 3 groups (p < 0.001 for all). Cholecalciferol 9-19 interleukin 6 Homo sapiens 62-66 30533524-8 2018 Conclusions: Although supplementation with vitamin D3 reduced the mRNA expression levels of IL-17A and IL-6, it increased the mRNA expression level of IL-10 in all groups. Cholecalciferol 43-53 interleukin 6 Homo sapiens 103-107 30533524-10 2018 Of interest, in a deficiency state of serum vitamin D3, IL-17A expression had a positive feedback effect on the expression of IL-6. Cholecalciferol 44-54 interleukin 6 Homo sapiens 126-130 32356241-7 2020 The current in vitro work on a human HCT116 cell line displayed that NTZ had lower IC50 value (11.20 microM) than 5-flurouracil (23.78 microM), and NTZ induced a statistically significant down-regulation of IL6/JAK2/STAT3. nitazoxanide 69-72 interleukin 6 Homo sapiens 207-210 31737185-10 2019 At the molecular level, saxagliptin suppresses OGD/R-induced expression of pro-inflammatory cytokines and production of vascular adhesion molecules including tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, monocyte chemoattractant protein 1 (MCP-1), vascular cellular adhesion molecule 1 (VCAM-1), and E-selectin. saxagliptin 24-35 interleukin 6 Homo sapiens 199-217 32356241-7 2020 The current in vitro work on a human HCT116 cell line displayed that NTZ had lower IC50 value (11.20 microM) than 5-flurouracil (23.78 microM), and NTZ induced a statistically significant down-regulation of IL6/JAK2/STAT3. nitazoxanide 148-151 interleukin 6 Homo sapiens 207-210 31502760-7 2019 Highly localized SA delivery results in a significant decrease in cytokine (tumor necrosis factor alpha and interleukin 6) levels after lipopolysaccharide stimulation. Salicylic Acid 17-19 interleukin 6 Homo sapiens 108-121 29939445-14 2018 Ruxolitinib also significantly inhibited the production of IL-6, TNF-alpha and MCP-1 as induced by A23817 and substance P. Selective STAT5 inhibition with pimozide resulted in diminished degranulation and inhibition of cytokine production as induced by A23817 and substance P. CONCLUSIONS & CLINICAL RELEVANCE: This study demonstrates that the JAK1/JAK2 inhibitor ruxolitinib can inhibit MCactivity, possibly through prevention of STAT5 activation. a23817 99-105 interleukin 6 Homo sapiens 59-63 32356241-11 2020 In conclusion, our findings provided a novel evidence that NTZ could be a dual potential IL6/JAK2/STAT3 signaling inhibitor and p53/caspases-dependent pathway activator in CRC cell line. nitazoxanide 59-62 interleukin 6 Homo sapiens 89-92 30125779-4 2018 Our data suggested that the treatment of chronically induced THP-1 macrophages and N9 microglial cells with sAbeta1-42 can suppress the major inflammatory cytokine TNF-alpha without affecting the level of IL-6. sabeta1-42 108-118 interleukin 6 Homo sapiens 205-209 32423164-7 2020 Increased concentration of individual polyphenols was directly associated with improved ability of sprouts for radical scavenging and reduction of tumor necrosis factor alpha and interleukin 6 in macrophages. Polyphenols 38-49 interleukin 6 Homo sapiens 179-192 30376894-8 2018 The mAb from clone KH4-8 effectively inhibited increases in interleukin-6 (IL-6) and IL-8 expression in recombinant adiponectin-stimulated human osteoblasts and human umbilical vein endothelial cells. kh4-8 19-24 interleukin 6 Homo sapiens 60-73 30376894-8 2018 The mAb from clone KH4-8 effectively inhibited increases in interleukin-6 (IL-6) and IL-8 expression in recombinant adiponectin-stimulated human osteoblasts and human umbilical vein endothelial cells. kh4-8 19-24 interleukin 6 Homo sapiens 75-79 32802107-8 2019 Administration of calcitriol in patients with non-ST-segment elevation acute coronary syndromes undergoing elective PCI can attenuate the increase in serum inflammatory biomarkers in the serum (hs-CRP and hs-IL-6) and thus decrease the inflammatory reaction caused by PCI. Calcitriol 18-28 interleukin 6 Homo sapiens 208-212 31778176-9 2019 The utilization of extracellular choline by the four Legionella species leads to changes not only in the lipid components but also in proteins, and the interactions between these components lead to changes in cell surface properties, which result in a decline in induction of proinflammatory cytokines (TNF-alpha and IL-6). Choline 33-40 interleukin 6 Homo sapiens 317-321 31011875-6 2019 Histological and biochemical analyses showed that the VOB-treated wounds exhibited a significant increase of granular tissue and controlled inflammatory response by modulation of the release of pro-inflammatory cytokines TNF-alpha, IL-6 and IL-1. vob 54-57 interleukin 6 Homo sapiens 232-236 32312819-7 2020 Furthermore, glutamine deprivation, as well as the antimetabolic drugs 2-deoxyglucose and metformin, also promoted the release of IL-6 and IL-8. Deoxyglucose 71-85 interleukin 6 Homo sapiens 130-134 31173888-6 2019 In AA-derived CD4+ T-cell cultures, 1,25(OH)2D3 was less efficient at inhibiting IL-5, IL-6 and IL-17 production, and up regulating IL-10 release, as those from healthy subjects. Calcitriol 36-47 interleukin 6 Homo sapiens 87-91 30348950-9 2018 Azithromycin showed the same effect in imitated SLE macrophages, with distinct Akt phosphorylation at 30 min and 12 h. After inhibiting Akt phosphorylation by LY294002, the down-regulation of CD80, IL-1beta, IL-6, and TNF-alpha caused by azithromycin raised again, meanwhile, the up-regulation of CD206, Arg-1, Fizz-1, and IL-10 due to azithromycin was abolished. Azithromycin 0-12 interleukin 6 Homo sapiens 208-212 32205228-12 2020 Among obese participants (n = 108), benzene, lead, and cadmium were each positively associated with CK18 M30, IL-1beta, IL-6, and IL-8. Benzene 36-43 interleukin 6 Homo sapiens 120-124 30406037-8 2018 However, the levels of interleukins [IL-6, IL-10, granulocyte colony stimulating factor (GCSF), and transforming growth factor beta1 (TGFbeta1)] were higher in patients with AP-ALA, whereas in patients with R-ALA, higher levels of interferon gamma (IFNgamma) were detected. ap-ala 174-180 interleukin 6 Homo sapiens 37-41 30218778-8 2018 A substantially increased inflammatory response to CoA-based ES was observed, with upregulation of IL-6 expression and a significant M2 macrophage presence. Einsteinium 61-63 interleukin 6 Homo sapiens 99-103 31472054-12 2019 Treatment of HCT116 cells with sesamolin significantly and dose-dependently reduced the levels of IL-6-induced expressions of MMP-1, MMP-2 and MMP-9 (p &lt; 0.05). sesamolin 31-40 interleukin 6 Homo sapiens 98-102 32176561-11 2020 Notably, the exogenous pyrogen lipopolysaccharide (LPS) significantly promoted IL-6 mRNA expression and caspase-3 activity but did not induce apoptotic cell formation. pyrogen lipopolysaccharide 23-49 interleukin 6 Homo sapiens 79-83 31239367-10 2019 miR-142-3p inhibitor significantly decreased the cell viability, the number of cell clones, the migration rate, the number of invasive cells, the contents and expression of IL-6 and MMP-3, and increased the apoptosis rate and the expressions of Bax and Bad, and decreased Bcl-2 expression of TNF-alpha-treated RA-HFLSs. mir-142-3p 0-10 interleukin 6 Homo sapiens 173-177 30324111-14 2018 Regarding inflammatory cytokines, genistein and L-carnitine had less effect on TNF-alpha than on IL-6. Carnitine 48-59 interleukin 6 Homo sapiens 97-101 30298070-8 2018 In anemic pregnant and non-pregnant women with minor beta-thalassemia, presenting undetectable hepcidin levels, differently from ferrous sulfate management, bLf decreased IL-6 (from 25 +- 8 to 6 +- 3 pg/ml) and increased total serum iron (TSI) (from 54 +- 17 to 80 +- 9 mug/dl). CHEMBL2024323 157-160 interleukin 6 Homo sapiens 171-175 32365773-0 2020 Sildenafil Reduces Expression and Release of IL-6 and IL-8 Induced by Reactive Oxygen Species in Systemic Sclerosis Fibroblasts. Sildenafil Citrate 0-10 interleukin 6 Homo sapiens 45-49 30922625-6 2019 To investigate the role of Stat3 in endometrial cancer invasive capacity, we used Stat3 inhibitor Stattic and found that Stattic significantly inhibited the migration and invasion of endometrial cancer cells elevated by IL-6. stattic 121-128 interleukin 6 Homo sapiens 220-224 30233647-10 2018 The performance confirmation of these last results with the validation dataset, indicated that the highest sensitivity, accuracy, and NPV (99.44%, 99.44%, and 96.88, respectively) were attained with HSF+SSF-like or HSF+SSF-like+MES for donor sites and SSF-like (92.63%, 92.65%, and 84.44, respectively) for acceptor sites. 2-(N-morpholino)ethanesulfonic acid 228-231 interleukin 6 Homo sapiens 199-202 32365773-5 2020 Treatment with sildenafil significantly reduced dermal fibroblast gene expression and cellular release of IL-6, known to play a central role in the pathogenesis of tissue damage in SSc and IL-8, directly induced by ROS. Sildenafil Citrate 15-25 interleukin 6 Homo sapiens 106-110 30233647-10 2018 The performance confirmation of these last results with the validation dataset, indicated that the highest sensitivity, accuracy, and NPV (99.44%, 99.44%, and 96.88, respectively) were attained with HSF+SSF-like or HSF+SSF-like+MES for donor sites and SSF-like (92.63%, 92.65%, and 84.44, respectively) for acceptor sites. 2-(N-morpholino)ethanesulfonic acid 228-231 interleukin 6 Homo sapiens 215-218 31987922-7 2020 Moreover, Nano-DOX also suppressed stimulated activation of STAT3 and IL-6 induced by temozolomide, a first-line anti-GBM chemotherapy, resistance to which critically involves STAT3 activation. temozolomide 86-98 interleukin 6 Homo sapiens 70-74 30109169-12 2018 The increased IL-6 may contribute to sunitinib resistance either via VEGF-mediated angiogenesis or through shifting of the Bcl2/Bax balance in favour of anti-apoptosis. Sunitinib 37-46 interleukin 6 Homo sapiens 14-18 30042932-7 2018 Inhibition of Notch signaling by gamma-secretase inhibitor DAPT impairs TLR4-stimulated accumulation of NF-kappaB subunits p65 in the nucleus and subsequently reduces LPS- and infection-mediated IL-6 production. dapt 59-63 interleukin 6 Homo sapiens 195-199 30690080-11 2019 AM did not affect the secretion of IL-6 or IL-8 by EC but stimulated the secretion of IL-6 by ASMC. asmc 94-98 interleukin 6 Homo sapiens 86-90 30792116-5 2019 Terpinolene and alpha-phellandrene significantly increased the migration and proliferation of fibroblasts and suppressed the pro-inflammatory cytokines IL-6 and TNF-alpha in a dose-dependent manner. terpinolene 0-11 interleukin 6 Homo sapiens 152-156 31114197-8 2019 Encapsulated calcitriol diminished mRNA gene levels of TNF-, NF-B, MCP-1 and IL-6, while upregulating IL-10. Calcitriol 13-23 interleukin 6 Homo sapiens 77-81 32228672-8 2020 RESULTS: Ibrutinib was able to reduce the production of the profibrotic hallmark cytokines IL-6 and TNF-alpha mainly from the effector B cell population in patients with SSc. ibrutinib 9-18 interleukin 6 Homo sapiens 91-95 30597391-8 2019 Elevated blood Pb, urinary 2-hydroxynaphthalene (2-OHNap) and SigmaOHFlu levels were associated with higher levels of IL-6, IL-12p70, IP-10, CD4+ T cell percentages, neutrophil and monocyte counts. 2-naphthol 27-47 interleukin 6 Homo sapiens 118-122 30728070-9 2019 The HDAC6-selective inhibitors ACY-1215 (ricolinostat) and ACY-241 (citarinostat) decreased Th2 cytokine production (i.e. IL-4, IL-5, IL-6, IL-10 and IL-13). ricolinostat 31-39 interleukin 6 Homo sapiens 134-138 29955370-13 2018 The most powerful correlations to PtGDA was observed with p-albumin (rho=-0.42), IL-6 (rho=0.30) and TNF-alpha (rho=0.29). ptgda 34-39 interleukin 6 Homo sapiens 81-85 32292492-7 2020 Methylprednisolone group, compared to Cytosorb and Control had significantly lower levels of TNF-alpha (until the end of surgery, p < 0.001), IL-6 (until 48 h after surgery, p < 0.001), and IL-8 (until 24 h after surgery, p < 0.016). Methylprednisolone 0-18 interleukin 6 Homo sapiens 142-146 29496539-9 2018 Furthermore, sabutoclax effectively eliminated the CSC subpopulation and reduced sphere formation of drug-resistant cells through down-regulation of the IL-6/STAT3 signaling pathway. 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5-(2-phenylpropyl)-N5'-(2-phenylpropyl)-2,2'-binaphthyl-5,5'-dicarboxamide 13-23 interleukin 6 Homo sapiens 153-157 29496539-11 2018 Our findings indicate that sabutoclax partially overcomes the drug resistance phenotype of breast cancer cells by reactivation of apoptosis, mediated by the inhibition of several anti-apoptotic BCL-2 family proteins, and eliminates CSCs by abolition of the IL-6/STAT3 pathway. 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5-(2-phenylpropyl)-N5'-(2-phenylpropyl)-2,2'-binaphthyl-5,5'-dicarboxamide 27-37 interleukin 6 Homo sapiens 257-261 30630559-18 2019 CONCLUSION: Compared with midazolam-remifentanil intravenous anaesthesia, the dezocine-remifentanil method has a better analgesic effect, shorter wake-up time, and can effectively regulate the expression of inflammatory cytokines TNF-&alpha; and IL-6. Remifentanil 87-99 interleukin 6 Homo sapiens 250-254 30630560-10 2019 CONCLUSION: Compared with fentanyl combined anesthesia, the remifentanil combined anesthesia can significantly reduce serum levels of cytokines IL-8, IL-6, CRP, TNF- &alpha; and oxidative stress level, and is, therefore, more secure for patients undergoing laparoscopic surgery for colon cancer. Remifentanil 60-72 interleukin 6 Homo sapiens 150-154 31931060-4 2020 PPI network analysis in combination with KEGG pathways as well as the western blot and functional verification assays indicated that NF-kappaB and STATs were the key regulators modulating the expressions of core gene TNF-alpha and IL-6 individually, and the transposition activation of NF-kappaB was identified as an early event in macrophage activation induced by RAMPtp. ramptp 365-371 interleukin 6 Homo sapiens 231-235 29235373-8 2018 IL-6 was significantly associated with glycerol in all models (p < .05), with glycerol levels increasing by 106% in individuals with AGM after AP (p <.05) compared to a 30.3% increase in individuals with normal glucose metabolism (NGM) (p >.05). Arctigenin mustard 136-139 interleukin 6 Homo sapiens 0-4 30713180-1 2018 AIM: Evaluation of the effect of glucosamine-chondroitin combination, tramadol, and sodium hyaluronic acid in temporomandibular joint (TMJ) disorders and its impact on the expression of various cytokines such as IL-6, IL-1beta, TNF-alpha, and PGE2. Glucosamine 33-44 interleukin 6 Homo sapiens 212-216 29533840-10 2018 RESULTS: In adjusted models, we observed positive relationships between PBDEs and pro-inflammatory cytokines (IL-6 and TNF-alpha). Halogenated Diphenyl Ethers 72-77 interleukin 6 Homo sapiens 110-114 29533840-11 2018 A doubling in PBDEs was associated with a 15.26% (95% CI 1.24, 31.22) and 3.74% (95% CI -0.19, 7.82) increase in IL-6 and TNF-alpha, respectively. Halogenated Diphenyl Ethers 15-20 interleukin 6 Homo sapiens 114-118 31952790-2 2020 Studies suggest that estrogen can inhibit IL-6/gp130 signaling and reduce the risk of coronary artery disease, but the precise mechanism is unclear. Estrogens 21-29 interleukin 6 Homo sapiens 42-46 29349683-5 2018 PMS (20 and 40 mug/ml) decreased the expression levels of MUC5AC, IL-6, and IL-1beta, which were induced by LPS treatment. plantamajoside 0-3 interleukin 6 Homo sapiens 66-70 29644527-4 2018 In human hepatoma cells, gemcabene inhibited IL-6 plus IL-1beta-induced CRP production in a concentration-dependent manner, reaching 70% inhibition at 2 mM. gemcabene 25-34 interleukin 6 Homo sapiens 45-49 32182747-8 2020 However, a significant effect was observed in IL1beta (p = 0.011) and IL6 (p = 0.009), which showed significantly lower values after DHA consumption than after placebo ingestion. Docosahexaenoic Acids 133-136 interleukin 6 Homo sapiens 70-73 30591798-7 2018 The results from RT-PCR analysis revealed a significant reduction in the expression of genes involved in inflammation including, HMGB1, IL-6 and IL-8 on treatment of DU-145 cells with crocetin. crocetin 184-192 interleukin 6 Homo sapiens 136-140 29431349-3 2018 The aim of our study was to evaluate the effect of active vitamin D3 (VD) on the expression of pro-inflammatory and anti-inflammatory cytokines (IL-6, IL-8, IL-10 and IL-12) in human gingival fibroblasts (hGF) and human periodontal ligament cells (hPDLc) triggered by Porphyromonas gingivalis and Streptococcus pyogenes. Cholecalciferol 58-68 interleukin 6 Homo sapiens 145-149 32327953-2 2020 The aim of this article was to demonstrate the effects of grape polyphenols on the selected inflammatory mediators, such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-a), and high-sensitivity C-reactive protein (hs-CRP). Polyphenols 64-75 interleukin 6 Homo sapiens 124-137 29862139-10 2018 Furthermore, TcES-treated eyes were shown to have increased IL-10 expression, with a corresponding reduction in IL-6 and COX-2 expression as well as reduction in NF-kappaB phosphorylation. tces 13-17 interleukin 6 Homo sapiens 112-116 30077906-7 2018 MCN, MCN-PVP and MCN-PEG promoted the differentiation and maturation of the DCs, while the levels of secreted TNF-alpha and IL-6 were significantly suppressed by MCN-PVP and MCN-PEG. mcn 0-3 interleukin 6 Homo sapiens 124-128 30114464-6 2018 Of note, the mRNA levels of IL-6 and IL-8 were approximately two-fold higher when cells were stimulated with 3 x 107 CFU/ml of r-SP for 3 h, while the protein levels of IL-6 and IL-8 were approximately five-fold higher after stimulation with 3 x 107 CFU/ml of r-SP for 24 h. Furthermore, r-SP exhibited potent activation of Toll-like receptor 2 compared with h-SP or f-SP. r-sp 127-131 interleukin 6 Homo sapiens 28-32 32142484-13 2020 DISCUSSION: Sequential administration of parecoxib and celecoxib in patients with predicted SAP obtained about half-reduction of SAP occurrence through decreasing serum levels of TNF-alpha and IL-6. Celecoxib 55-64 interleukin 6 Homo sapiens 193-197 30114464-6 2018 Of note, the mRNA levels of IL-6 and IL-8 were approximately two-fold higher when cells were stimulated with 3 x 107 CFU/ml of r-SP for 3 h, while the protein levels of IL-6 and IL-8 were approximately five-fold higher after stimulation with 3 x 107 CFU/ml of r-SP for 24 h. Furthermore, r-SP exhibited potent activation of Toll-like receptor 2 compared with h-SP or f-SP. r-sp 127-131 interleukin 6 Homo sapiens 169-173 30114464-6 2018 Of note, the mRNA levels of IL-6 and IL-8 were approximately two-fold higher when cells were stimulated with 3 x 107 CFU/ml of r-SP for 3 h, while the protein levels of IL-6 and IL-8 were approximately five-fold higher after stimulation with 3 x 107 CFU/ml of r-SP for 24 h. Furthermore, r-SP exhibited potent activation of Toll-like receptor 2 compared with h-SP or f-SP. r-sp 260-264 interleukin 6 Homo sapiens 28-32 30114464-6 2018 Of note, the mRNA levels of IL-6 and IL-8 were approximately two-fold higher when cells were stimulated with 3 x 107 CFU/ml of r-SP for 3 h, while the protein levels of IL-6 and IL-8 were approximately five-fold higher after stimulation with 3 x 107 CFU/ml of r-SP for 24 h. Furthermore, r-SP exhibited potent activation of Toll-like receptor 2 compared with h-SP or f-SP. r-sp 260-264 interleukin 6 Homo sapiens 28-32 29410184-0 2018 Interleukin-6 potentiates FcepsilonRI-induced PGD2 biosynthesis and induces VEGF from human in situ-matured skin mast cells. Prostaglandin D2 46-50 interleukin 6 Homo sapiens 0-13 29410184-8 2018 RESULTS: IL-6 significantly potentiated FcepsilonRI-induced PGD2 biosynthesis, but had no effect on degranulation. Prostaglandin D2 60-64 interleukin 6 Homo sapiens 9-13 29410184-10 2018 Mechanistically, IL-6 enhanced FcepsilonRI-induced COX-2 expression, PGD2 biosynthesis, and VEGF production in a STAT3 dependent manner. Prostaglandin D2 69-73 interleukin 6 Homo sapiens 17-21 29410184-11 2018 CONCLUSION: Here, we demonstrate that IL-6 is a potentiator of FcepsilonRI-induced PGD2 biosynthesis, and can induce or enhance production of pro-angiogenesis factors VEGF and IL-8 from human in situ-matured skin mast cells. Prostaglandin D2 83-87 interleukin 6 Homo sapiens 38-42 29410184-12 2018 GENERAL SIGNIFICANCE: These findings from this study indicate that IL-6 contributes to human allergic disease by enhancing the production of inflammatory PGD2 from tissue-resident mast cells. Prostaglandin D2 154-158 interleukin 6 Homo sapiens 67-71 31802565-12 2020 Estrogen increased the proliferation and mobility of iheESCs and lipopolysaccharides (LPS) induced the IL-1beta and IL-6 promoting inflammatory response. Estrogens 0-8 interleukin 6 Homo sapiens 116-120 29715306-10 2018 AZI inhibited R848-induced TNF, IL-1beta, IL-6 and IL-10, and LPS-induced IL-1beta and IL-10. Azithromycin 0-3 interleukin 6 Homo sapiens 42-46 29852392-4 2018 Total glucosides of paeony (TGP) significantly improves the immunomodulatory function of MSCs by inhibiting IL-6 and TNF-alpha expression and increasing TGF-beta and IL-10 expression. Glucosides 6-16 interleukin 6 Homo sapiens 108-112 29760703-9 2018 Furthermore, an AAT inhibitor l-aspartate-beta-hydroxamate (HDX), which blocked the upregulation of endogenous SO2/AAT generation induced by CSE knockdown, aggravated CSE knockdown-activated nuclear factor-kappaB pathway in the endothelial cells and its downstream inflammatory factors including ICAM-1, TNF-alpha, and IL-6. ({3-Hydroxy-2-Oxo-4-[2-(Phosphonooxy)ethyl]pyridin-1(2h)-Yl}methyl)phosphonic Acid 60-63 interleukin 6 Homo sapiens 319-323 31655524-1 2020 INTRODUCTION/OBJECTIVES: Tumor necrosis factor inhibitors (TNFi) and anti-interleukin 6 (anti-IL-6) therapies are increasingly being used in Takayasu?s Arteritis (TA) patients unresponsive to corticosteroids +- conventional immunosuppressive agents. Adrenal Cortex Hormones 192-207 interleukin 6 Homo sapiens 94-98 30701854-9 2018 CONCLUSION: In patients with PD (both colchicin-resistant and colchicin-sensitive) increased serum concentration of IL-10 was accompanied by an increased level of IL-6 in serum. Colchicine 38-47 interleukin 6 Homo sapiens 163-167 29906742-6 2018 The levels of TNF-alpha, IL-1ss and IL-6 in kidney tissues were suppressed by xanthohumol. xanthohumol 78-89 interleukin 6 Homo sapiens 36-40 29976395-0 2018 Mulberry leaf extract inhibit hepatocellular carcinoma cell proliferation via depressing IL-6 and TNF-alpha derived from adipocyte. mulberry leaf 0-13 interleukin 6 Homo sapiens 89-93 31690224-5 2020 In vitro experiments in 16 HBE cells revealed that CTS attenuated CAM-1 and IL-6 expression. cryptotanshinone 51-54 interleukin 6 Homo sapiens 76-80 29946898-6 2018 IL-6 affected also the mitochondrial membrane potential together with elevated mitochondrial superoxide generation, and glycogen deposition was reduced. Glycogen 120-128 interleukin 6 Homo sapiens 0-4 29635790-3 2018 All the five compounds showed no cytotoxic activity against five human cancer cell lines, while popolohuanone H (2) showed potent inhibitory activity against IL-6, an inflammatory cytokine, at the concentration of 10 mum. popolohuanone h (2) 96-115 interleukin 6 Homo sapiens 158-162 30701854-9 2018 CONCLUSION: In patients with PD (both colchicin-resistant and colchicin-sensitive) increased serum concentration of IL-10 was accompanied by an increased level of IL-6 in serum. Colchicine 62-71 interleukin 6 Homo sapiens 163-167 29651140-0 2018 Novel Indole-fused benzo-oxazepines (IFBOs) inhibit invasion of hepatocellular carcinoma by targeting IL-6 mediated JAK2/STAT3 oncogenic signals. indole 6-12 interleukin 6 Homo sapiens 102-106 30972761-12 2020 Laryngomalacia could be an inflammatory disease due to 25(OH)-vitamin D deficiency as evidenced by the high level of IL-6. 25(oh) 55-61 interleukin 6 Homo sapiens 117-121 29532895-5 2018 The benzoxazole derivatives significantly reduced the expression of interleukin (IL)-1beta, IL-6, IL-13, tumor necrosis factor-alpha, perilipin (PLIN) 2, and PLIN3 in BMMCs treated with LPS. Benzoxazoles 4-15 interleukin 6 Homo sapiens 92-96 32467682-6 2020 In patients with psoriasis alone, the IL-6 serum concentration correlated positively with the concentrations of TC and LDL-c and with erythrocyte sedimentation rates (ESRs). Technetium 112-114 interleukin 6 Homo sapiens 38-42 28862770-7 2018 CONCLUSIONS: Both strategies alleviated symptoms in short term, but the patients treated with GS benefited more than those with placebo in long term, which may be due to the suppression of IL-1beta and IL-6 and the stimulation of TGF-beta. Glucosamine 94-96 interleukin 6 Homo sapiens 202-206 29405435-7 2018 High IL-6 levels measured within 24 hours of transplantation were associated with longer time on ICU and time to hospital discharge; and increased prevalence of PGD grade 3. Prostaglandins D 161-164 interleukin 6 Homo sapiens 5-9 29589999-11 2018 The IL-1beta-induced hyaluronan production and mRNA expression of IL-6, cyclooxygenase-2, and intercellular adhesion molecule-1 were also significantly suppressed after metformin or phenformin co-treatment. Phenformin 182-192 interleukin 6 Homo sapiens 66-70 32019154-9 2020 However, only individuals with the TT genotype presented reduced levels of Hcy, TNF-alpha, IL-6, and IL-1beta (p < 0.001). Thymine 35-37 interleukin 6 Homo sapiens 91-95 29515108-4 2018 Our studies reveal that sunitinib triggers two resistance-promoting signaling pathways in RCC cells, which emanate from the endoplasmic reticulum (ER) stress response: a PERK-driven ER stress response that induces expression of the pro-tumorigenic cytokines IL-6, IL-8, and TNF-alpha, and a TRAF2-mediated NF-kappaB survival program that protects tumor cells against cell death. Sunitinib 24-33 interleukin 6 Homo sapiens 258-262 29515108-5 2018 PERK blockade completely prevents sunitinib-induced expression of IL-6, IL-8 and TNF-alpha, whereas NF-kappaB inhibition reinstates sensitivity of RCC cells to sunitinib both in vitro and in vivo. Sunitinib 34-43 interleukin 6 Homo sapiens 66-70 29389973-7 2018 In addition, leptin, IL-6 and TNFalpha, at concentrations reflecting plasma concentrations in obese patients, decreased the anti-proliferative efficacy of 4-hydroxytamoxifen (a major active metabolite of Tx). hydroxytamoxifen 155-173 interleukin 6 Homo sapiens 21-25 29471675-8 2018 Moreover, these patients" cells had elevated basal IL-6 secretion that was enhanced by muramyl dipeptide (MDP) stimulation. Acetylmuramyl-Alanyl-Isoglutamine 87-104 interleukin 6 Homo sapiens 51-55 32430154-9 2020 LDL-c and TC levels inversely correlated with C-reactive protein and interleukin-6, and positively correlated with the number of lymphocytes in patients. Technetium 10-12 interleukin 6 Homo sapiens 69-82 29471675-8 2018 Moreover, these patients" cells had elevated basal IL-6 secretion that was enhanced by muramyl dipeptide (MDP) stimulation. Acetylmuramyl-Alanyl-Isoglutamine 106-109 interleukin 6 Homo sapiens 51-55 29168867-8 2018 In this study, we found that phloretin significantly inhibited the IL-1beta-induced production of NO, PGE2, TNF-alpha, and IL-6, the expression of COX-2, iNOS, MMP-3, MMP-13, and ADAMTS-5, and the degradation of aggrecan and collagen-II in human OA chondrocytes. Phloretin 29-38 interleukin 6 Homo sapiens 123-127 29491712-5 2018 In addition, BGW supplementation prevented the increase in tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 induced by T2DM. 1-(4-(benzothiazol-2-yloxy)benzyl)piperidine-4-carboxylic acid 13-16 interleukin 6 Homo sapiens 97-115 29568771-6 2018 Lower serum IL-6 was detected in the triclosan group at 4 weeks and 3 months. Triclosan 37-46 interleukin 6 Homo sapiens 12-16 31718146-5 2019 Additionally, results demonstrated that the inflammatory responses of cells stimulated by gas pollution (formaldehyde (FA) and benzene (Ben) as models) from gas phase were more obvious than those induced by gas pollution from solution, especially the increment of interleukin-2 (IL-2), IL-6 and tumor necrosis factor alpha (TNF-alpha) was almost 2 times larger than that induced by gas pollution from solution. Benzene 136-139 interleukin 6 Homo sapiens 286-290 29938621-0 2018 A Novel Combination of omega-3 Fatty Acids and Nano-Curcumin Modulates Interleukin-6 Gene Expression and High Sensitivity C-reactive Protein Serum Levels in Patients with Migraine: A Randomized Clinical Trial Study. nano-curcumin 47-60 interleukin 6 Homo sapiens 71-84 29938621-6 2018 RESULTS: The results showed that both of omega-3 and nano-curcumin down-regulated IL-6 mRAN and significantly decreased the serum concentration. nano-curcumin 53-66 interleukin 6 Homo sapiens 82-86 29419731-9 2018 Moreover, levels of interleukin (IL)-6, one of the most important cytokines in chronic inflammation, in cultured supernatants were higher in PP and MPM patients compared with HD. mpm 148-151 interleukin 6 Homo sapiens 20-38 31824138-0 2019 Cinobufagin Suppresses The Characteristics Of Osteosarcoma Cancer Cells By Inhibiting The IL-6-OPN-STAT3 Pathway. cinobufagin 0-11 interleukin 6 Homo sapiens 90-94 29128404-10 2018 No differences in ZO-1 relative expression patterns were observed in cultured cells, with increased expression in IL-6 in cells exposed to nTg milk than controls, with the Tg group being similar to all groups. Nitroglycerin 139-142 interleukin 6 Homo sapiens 114-118 29359392-6 2018 In this study, we report that the interaction of HBD-3 with PI(4,5)P2 is important for PI3K-Akt-NF-kappaBeta-mediated induction of tumor necrosis factor and interleukin-6. pi(4,5)p2 60-69 interleukin 6 Homo sapiens 157-170 29594564-5 2017 Graphical abstract Schematic of a novel photoelectochemical immunoassay for the measurement of IL-6 based on perovskite-type LaFeO3 nanoparticles. type lafeo3 120-131 interleukin 6 Homo sapiens 95-99 31824138-16 2019 From a mechanistic point of view, cinobufagin was shown to inhibit IL-6-OPN-STAT3 signaling pathway. cinobufagin 34-45 interleukin 6 Homo sapiens 67-71 30380555-12 2018 We found a decrease of p-cresyl sulfate (PCS) of 3 studies with 125 subjects (P = 0.01, SMD -0.57, 95% CI, -0.99 to -0.14, I2 = 25%) and an increase of IL-6 in 3 studies with 134 subjects (P = 0.03, 95% CI, SMD 0.37, 0.03 to 0.72, I2 = 0%) in the probiotics groups. 4-cresol sulfate 41-44 interleukin 6 Homo sapiens 152-156 31824138-18 2019 Conclusion: Collectively, our data demonstrated that cinobufagin inhibited the viability and tumorigenesis capability of osteosarcoma cells by blocking IL-6- OPN-STAT3 signaling pathway. cinobufagin 53-64 interleukin 6 Homo sapiens 152-156 31789935-1 2019 OBJECTIVES: Inflammation-associated microsatellite alterations (also known as elevated microsatellite alterations at selected tetranucleotide repeats [EMAST]) result from IL-6-induced nuclear-to-cytosolic displacement of the DNA mismatch repair (MMR) protein MSH3, allowing frameshifts of dinucleotide or longer microsatellites within DNA. tetranucleotide 126-141 interleukin 6 Homo sapiens 171-175 30029729-7 2018 The in vitro inhibition of IL-6 secretion in hMSCs by DHEA was more consistent and extensive than by estradiol or dihydrotestosterone. Dihydrotestosterone 114-133 interleukin 6 Homo sapiens 27-31 28900748-8 2017 The pain VAS score (r = 0.22, p = 0.02) and serum IL-6 level (r = 0.31, p < 0.01) were independently associated with the SDS score of all early-stage knee OA patients (Kellgren-Lawrence [K/L] grade 2). sds 124-127 interleukin 6 Homo sapiens 50-54 28900748-9 2017 However, only the serum IL-6 level was independently associated with the SDS scores of advanced-stage knee OA patients (K/L grades 3 and 4, r = 0.36, p < 0.01). sds 73-76 interleukin 6 Homo sapiens 24-28 28900748-10 2017 A logistic regression analysis revealed that serum IL-6 level was the variable for the SDS score [odds ratio 1.41 (95% confidence interval 1.03-1.94, p < 0.03)]. sds 87-90 interleukin 6 Homo sapiens 51-55 29024522-8 2017 Rather, application of Kappa carrageenan significantly increased TEER and suppressed interleukin 6 (IL-6) secretion in ALI cultures from CRS patients. Carrageenan 23-40 interleukin 6 Homo sapiens 85-98 31646767-3 2019 We applied the models to simulate methylprednisolone dosages resulting in the desired IL-6 and -10 exposures, known mediators of CPB-induced inflammation. Methylprednisolone 34-52 interleukin 6 Homo sapiens 86-98 29024522-8 2017 Rather, application of Kappa carrageenan significantly increased TEER and suppressed interleukin 6 (IL-6) secretion in ALI cultures from CRS patients. Carrageenan 23-40 interleukin 6 Homo sapiens 100-104 29024522-10 2017 Kappa carrageenan increased TEER and decreased IL-6 production in CRS patients, indicating positive effects on epithelial barrier function in vitro. Carrageenan 6-17 interleukin 6 Homo sapiens 47-51 28864214-4 2017 Moreover, levels of serum miR-218 positively correlated with FEV1/FVC% and negatively correlated with levels of serum IL-6 and IL-8. mir-218 26-33 interleukin 6 Homo sapiens 118-122 31646767-5 2019 Methylprednisolone plasma exposure following a single 10 mg/kg intravenous dose inhibited IL-6 and stimulated IL-10 production when compared with placebo. Methylprednisolone 0-18 interleukin 6 Homo sapiens 90-94 28743324-3 2017 Triptolide pretreatment significantly inhibited tumor necrosis factor-alpha-induced expression of the interleukin (IL)-1beta, IL-6, and IL-8 genes in MH7A cells. triptolide 0-10 interleukin 6 Homo sapiens 126-130 28649040-6 2017 The OPAO assay showed the best correlation with the production of intracellular reactive oxygen species by NCI-H292 cell line assessed by DCFH oxidation and with the expression of anti-oxidant genes (superoxide dismutase 2, heme-oxygenase-1) as well as the proinflammatory response (Interleukin 6) when exposed from 1 to 10 mug/cm2. opao 4-8 interleukin 6 Homo sapiens 283-296 31759770-10 2019 LPS-stimulated production of IL-6 correlated negatively with the parenteral dose of eicosapentaenoic acid + docosahexaenoic acid. Docosahexaenoic Acids 108-128 interleukin 6 Homo sapiens 29-33 28901512-7 2017 Treatment with gambogic acid suppressed the activities of interleukin (IL)-1beta and IL-6, promoted the protein expression of phosphorylated (p)-Akt serine/threonine kinase (Akt), p-mammalian target protein of rapamycin (mTOR) and inhibited hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression in RA rats. gambogic acid 15-28 interleukin 6 Homo sapiens 85-89 28535933-11 2017 Additional ex vivo studies confirmed reduced induction of IL-6 (P = 0.017) and CXCL8/IL-8 (P = 0.005) with azithromycin. Azithromycin 107-119 interleukin 6 Homo sapiens 58-62 31493545-6 2019 It was found as expected that AgNP induced significant release of IL-1beta, IL-6, IL-8 and TNF-alpha in THP1 monocytes more than the basal level. agnp 30-34 interleukin 6 Homo sapiens 76-80 28371277-7 2017 The miR-138 mimic and LY294002 groups showed decreased concentrations of TNF-alpha, IL-6, IL-8 and NO and reduced activities of LDH and eNOS, while opposite trends were observed in the miR-138 inhibitor group. mir-138 4-11 interleukin 6 Homo sapiens 84-88 29084133-6 2017 In addition, senescence/inflammation markers such as IL-6 and metalloprotease secretion, and Ciclooxigenase type 2 (COX-2) and alpha-smooth-actin levels were reduced by phenol treatments. Phenol 169-175 interleukin 6 Homo sapiens 53-77 31542660-4 2019 Immune cells exposed to PCP at 0.05-5 muM and DDT at 0.025-2.5 muM showed increased secretion of IL-6 when the cell preparations contained either T lymphocytes or monocytes. Pentachlorophenol 24-27 interleukin 6 Homo sapiens 97-101 28346799-3 2017 Lipopolysaccharides (LPS), a polysaccharide in the outer membrane of Gram-negative bacteria, elicit strong immune responses, which was often applied to activate macrophages, resulting in a proinflammatory M1 phenotype, and the release of proinflammatory cytokines, including tumor necrosis factor alpha (TNFalpha), interleukin (IL)-1, and IL-6. Polysaccharides 4-18 interleukin 6 Homo sapiens 339-343 28300071-5 2017 The present results showed that three cytosine-phosphate-guanine (CpG) sites of IL-6 promoter CpG island had different lower methylation in EH group compared with controls, but only CpG2 (58.43+-7.53 versus 62.34+-9.65, P=0.004) and CpG3 (51.52+-6.18 versus 57.45+-8.29, P<0.001) had statistical difference. cytosine-phosphate-guanine 38-64 interleukin 6 Homo sapiens 80-84 31542660-5 2019 Increased IL-6 secretion was due to PCP and DDT induced cellular production of the cytokine and was dependent on MAP kinase signaling pathways (in the case of PCP). Pentachlorophenol 36-39 interleukin 6 Homo sapiens 10-14 28914813-5 2017 In pregnant women, affected by AI, bLf oral administration decreases IL-6 and increases hematological parameters. CHEMBL2024323 35-38 interleukin 6 Homo sapiens 69-73 31542660-7 2019 Thus, both PCP and DDT have the potential to produce chronic inflammation by stimulating production of IL-6 by immune cells. Pentachlorophenol 11-14 interleukin 6 Homo sapiens 103-107 30856080-10 2019 These studies demonstrated that vitamin E, especially tocotrienol, was able to alleviate IL-1, IL-6, RANKL, iNOS and hs-CRP levels in relation to bone metabolism. Tocotrienols 54-65 interleukin 6 Homo sapiens 95-99 28652177-0 2017 Inhibition of IL-6 and IL-8 production in LPS-stimulated human gingival fibroblasts by glycyrrhizin via activating LXRalpha. Glycyrrhizic Acid 87-99 interleukin 6 Homo sapiens 14-18 28652177-5 2017 The results showed that glycyrrhizin significantly inhibited LPS-induced IL-6 and IL-8 production, as well as COX-2 and iNOS expression. Glycyrrhizic Acid 24-36 interleukin 6 Homo sapiens 73-77 28652177-8 2017 In addition, the inhibition of glycyrrhizin on IL-6 and IL-8 production was reversed by LXRalpha inhibitor GGPP. Glycyrrhizic Acid 31-43 interleukin 6 Homo sapiens 47-51 28636034-6 2017 However, zinc(ii)-protoporphyrin IX (ZnPPIX), a selective inhibitor of HO-1, restored the GHP-mediated suppression of ROS production and NOX2, TNF-alpha, IL-1beta, IL-6 and iNOS expression. znppix 37-43 interleukin 6 Homo sapiens 164-168 28369685-8 2017 KEY RESULTS: Isorhapontigenin concentration-dependently inhibited IL-6 and CXCL8 release, with IC50 values at least twofold lower than those of resveratrol. isorhapontigenin 13-29 interleukin 6 Homo sapiens 66-70 31012803-7 2019 Also, significant changes were observed in interleukin (IL)-6 levels in magnesium and choline-magnesium groups (p < 0.05). Magnesium 72-81 interleukin 6 Homo sapiens 43-61 28444964-11 2017 The interleukin 6 level was significantly lower on days 3 and 5 after surgery in the landiolol group (P = 0 001 and P = 0 002 respectively). landiolol 85-94 interleukin 6 Homo sapiens 4-17 28713932-10 2017 In addition, adecline in the levels of the inflammatory cytokines, TNF-alpha and IL-6, and the oxidative activities, reflected by an increase in SOD and a decrease in MDA (P<0.05, vs. LPS group) were observed. adecline 13-21 interleukin 6 Homo sapiens 81-85 27557477-0 2017 Effect of proinflammatory cytokine IL-6 on efflux transport of rebamipide in Caco-2 cells. rebamipide 63-73 interleukin 6 Homo sapiens 35-39 31012803-7 2019 Also, significant changes were observed in interleukin (IL)-6 levels in magnesium and choline-magnesium groups (p < 0.05). Magnesium 94-103 interleukin 6 Homo sapiens 43-61 27557477-2 2017 Effect of IL-6, a pro-inflammatory cytokine, on efflux transport of rebamipide, an antiulcer drug, was investigated in Caco-2 cells. rebamipide 68-78 interleukin 6 Homo sapiens 10-14 31012803-9 2019 When adjusted for potential confounders, inflammation and endothelial factors (IL-6 and VCAM-1) decreased significantly in the choline-magnesium group as compared to other groups (p < 0.05). Magnesium 135-144 interleukin 6 Homo sapiens 79-83 28693192-3 2017 The results demonstrated that QNZ and regorafenib significantly reduced the expression and secretion levels of the angiogenesis- and metastasis-associated proteins vascular endothelial growth factor, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, matrix metalloproteinase (MMP)-2 and MMP-9, NF-kappaB activation and cell invasion. regorafenib 38-49 interleukin 6 Homo sapiens 253-257 31689825-0 2019 Polyphyllin I induces cell cycle arrest in prostate cancer cells via the upregulation of IL6 and P21 expression. polyphyllin I 0-13 interleukin 6 Homo sapiens 89-92 28133767-10 2017 In contrast, deletion of mIndy completely prevented the stimulating effect of IL-6 on citrate uptake and reduced hepatic lipogenesis. Citric Acid 86-93 interleukin 6 Homo sapiens 78-82 31689825-9 2019 Further studies showed that the upregulation of p21 expression induced by Polyphyllin I via the upregulation of IL6 expression. polyphyllin I 74-87 interleukin 6 Homo sapiens 112-115 28808406-13 2017 SUMMARY: Peimine inhibited the production of pro-inflammatory cytokines, such as IL-6, IL-8, and TNF-alphaPeimine reduced MAPKs phosphorylation and the nuclear NF-kappaB expression in PMACI-induced HMC-1Peimine decreased PCA reactions in ratsPeimine has anti-allergic effect through regulation of pro-inflammatory mechanism on mast cell. alphapeimine 101-113 interleukin 6 Homo sapiens 81-85 31689825-10 2019 CONCLUSION: Polyphyllin I could induce cell cycle arrest in G0/G1 phase in prostate cancer cells by upregulating the expression of P21 and IL6. polyphyllin I 12-25 interleukin 6 Homo sapiens 139-142 31594856-7 2019 Antibody-mediated blockade of GPIbalpha or of its receptor, Mac-1 integrin, inhibited the secretion of PGE2, IL-1beta, and IL-6 in MDP + Tc CM-activated monocytes, whereas recombinant GPIbalpha protein increased PGE2 production by MDP-treated monocytes. Technetium 137-139 interleukin 6 Homo sapiens 123-127 28402274-3 2017 Meantime, GM attenuated serum and HepG2 cell supernatant levels of TNF-alpha, IL-6, IL-1beta, SOD and MDA. gm 10-12 interleukin 6 Homo sapiens 78-82 28903416-7 2017 786-O RCC cells secrete high IL-6 levels after low dose stimulation with the TKIs sorafenib, sunitinib and pazopanib, inducing activation of AKT-mTOR pathway, NFkappaB, HIF-2alpha and VEGF expression. Sunitinib 93-102 interleukin 6 Homo sapiens 29-33 31515600-5 2019 The objective of this work was to investigate the molecular toxicology and local activation of BaP and PhIP in the presence of IL-6. Benzo(a)pyrene 95-98 interleukin 6 Homo sapiens 127-131 28501579-5 2017 Concomitantly, MAG-EPA also abolished LPS-induced inflammation in PBMCs by reducing IL-1beta, IL-6, and TNFalpha cytokines at protein and transcript levels. 1-eicosapentaenoylglycerol 15-22 interleukin 6 Homo sapiens 94-98 28288142-7 2017 Unbiased large-scale metabolomic analysis and transcriptome-wide mRNA expression profiling identified reduced levels of several metabolites of the amino sugar and nucleotide sugar metabolic pathways, including sialic acid N-acetylneuraminic acid (Neu5Ac), and downregulation of pro-oncogenic cytokines interleukin-6 and 8 (IL-6 and IL-8) as unexpected outcomes of SHMT1 loss. Amino Sugars 147-158 interleukin 6 Homo sapiens 323-327 28503530-7 2017 When compared the changes between groups (postvalues minus prevalues), there was lower glucose in CAF group when compared to CHO group (CAF= 5.0+-10.4 vs. CHO=27.8+-20 vs. P=15.1+-14, P=0.031) and higher IL-6 levels (CAF=11.9+-9.2 vs. CHO=-2.4+-1.7 vs. P=4.3+- 11.7, P=0.017). Caffeine 98-101 interleukin 6 Homo sapiens 204-208 28431555-11 2017 After 40 h exposure, EDTMP coated MOx show significant decreases of neutrophil counts, lactate dehydrogenase (LDH) release, MCP-1, LIX and IL-6 in bronchoalveolar lavage fluid (BALF), compared to uncoated particles. (ethylenedinitrilo)-tetramethylenephosphonic acid 21-26 interleukin 6 Homo sapiens 139-143 29798960-6 2017 In this study, we attempted to evaluate the effect of an alkaline phosphatase inhibitor, levamisole on expression of CD138, and level of interleukin-6 (IL-6) in human MM cell lines RPMI 8226 and U266 B1. rpmi 181-185 interleukin 6 Homo sapiens 137-150 31515600-12 2019 These data show that BaP- and PhIP-induced DNA damage in mammary cells is potentiated by the inflammatory cytokine IL-6 and that inflammation-induced CYP expression, specifically CYP1B1 via miR27b, is responsible for this effect. Benzo(a)pyrene 21-24 interleukin 6 Homo sapiens 115-119 29798960-6 2017 In this study, we attempted to evaluate the effect of an alkaline phosphatase inhibitor, levamisole on expression of CD138, and level of interleukin-6 (IL-6) in human MM cell lines RPMI 8226 and U266 B1. rpmi 181-185 interleukin 6 Homo sapiens 152-156 28299617-6 2017 In particular, methyl caffeate down-regulated SASP factors such as IL-1alpha, IL-1beta, IL-6, IL-8, GM-CSF, CXCL1, MCP-2, and MMP-3. methyl caffeate 15-30 interleukin 6 Homo sapiens 88-92 31540502-7 2019 EPDA suppressed the production of monocyte chemoattractant protein-1 (MCP-1), and interleukin-6 (IL-6) in both cell lines, and nitric oxide (NO), and macrophage-inflammatory protein-3alpha (MIP3A) in RAW 264.7 macrophages. epda 0-4 interleukin 6 Homo sapiens 82-95 28210968-10 2017 The secretions of cytokines (interleukin-6 and tumor necrosis factor-alpha) in critical-sized UHMWPE-ALN group were significantly lower than those in critical-sized UHMWPE group due to the released ALN. Alendronate 101-104 interleukin 6 Homo sapiens 29-74 28535046-3 2017 Pretreatment with piceatannol also inhibited TNF-alpha-induced expression of interleukin-6 (IL-6) and MCP-1 at both mRNA and protein levels in the 3T3-L1 adipocytes. 3,3',4,5'-tetrahydroxystilbene 18-29 interleukin 6 Homo sapiens 77-90 28535046-3 2017 Pretreatment with piceatannol also inhibited TNF-alpha-induced expression of interleukin-6 (IL-6) and MCP-1 at both mRNA and protein levels in the 3T3-L1 adipocytes. 3,3',4,5'-tetrahydroxystilbene 18-29 interleukin 6 Homo sapiens 92-96 31540502-7 2019 EPDA suppressed the production of monocyte chemoattractant protein-1 (MCP-1), and interleukin-6 (IL-6) in both cell lines, and nitric oxide (NO), and macrophage-inflammatory protein-3alpha (MIP3A) in RAW 264.7 macrophages. epda 0-4 interleukin 6 Homo sapiens 97-101 30541065-0 2019 Effect of Losartan and Fish Oil on Plasma IL-6 and Mobility in Older Persons. Losartan 10-18 interleukin 6 Homo sapiens 42-46 28655995-4 2017 The higher IL-6 expression was not related to transcriptional but posttranscriptional regulation as the IL-6 expression was affected by the addition of cycloheximide but not actinomycin. Cycloheximide 152-165 interleukin 6 Homo sapiens 11-15 28183591-8 2017 GO-CS/CpG ODNs complexes further resulted in an enhanced interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) production compared with that of free CpG ODNs and GO/CpG ODNs complexes. go-cs 0-5 interleukin 6 Homo sapiens 57-70 31397158-5 2019 Interleukin (IL)-6 was associated with Oxy-PAHs of 1,8-naphthalic anhydride, xanthone, and benzo[h]quinolone, especially, whereas IL-1beta and tumor necrosis factor (TNF)-alpha were associated with most species. xanthone 77-85 interleukin 6 Homo sapiens 0-18 28183591-8 2017 GO-CS/CpG ODNs complexes further resulted in an enhanced interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) production compared with that of free CpG ODNs and GO/CpG ODNs complexes. go-cs 0-5 interleukin 6 Homo sapiens 72-76 28655995-4 2017 The higher IL-6 expression was not related to transcriptional but posttranscriptional regulation as the IL-6 expression was affected by the addition of cycloheximide but not actinomycin. Cycloheximide 152-165 interleukin 6 Homo sapiens 104-108 31286307-5 2019 We also investigated whether preoperative administration of methylprednisolone decreased postoperative serum IL-6 levels in cancer patients in a randomized clinical study. Methylprednisolone 60-78 interleukin 6 Homo sapiens 109-113 28343970-0 2017 Phenylmethimazole and a thiazole derivative of phenylmethimazole inhibit IL-6 expression by triple negative breast cancer cells. phenyl methimazole 0-17 interleukin 6 Homo sapiens 73-77 28343970-0 2017 Phenylmethimazole and a thiazole derivative of phenylmethimazole inhibit IL-6 expression by triple negative breast cancer cells. phenyl methimazole 47-64 interleukin 6 Homo sapiens 73-77 28343970-2 2017 We previously reported that phenylmethimazole (C10) reduces IL-6 expression in several cancer cell lines. phenyl methimazole 28-45 interleukin 6 Homo sapiens 60-64 27484035-10 2017 Subsequent targeting studies demonstrated the importance of this lncRNA in controlling both proliferation and IL-6 release in ASMCs from patients with severe asthma. asmcs 126-131 interleukin 6 Homo sapiens 110-114 28063793-8 2017 Inhibition of JAK/STAT with AG490 (10muM) or piceatannol (50muM) blocked (P<0.01 10ng/mL IL-6vs. 3,3',4,5'-tetrahydroxystilbene 45-56 interleukin 6 Homo sapiens 92-96 28063793-9 2017 IL-6 plus AG490 or piceatannol) IL-6-induced increases in SPA and StAR mRNA. 3,3',4,5'-tetrahydroxystilbene 19-30 interleukin 6 Homo sapiens 32-36 31004874-8 2019 Cells transfected with HSD3B1-targeting small interfering RNA or treated with an HSD3B1 inhibitor (trilostane) had decreased IL-6 expression and secretion. trilostane 99-109 interleukin 6 Homo sapiens 125-129 28035387-13 2017 In conclusion, prednisone, ibuprofen and betamethasone may prevent OA by suppressing the expression of IL-6 and IL-8, subsequently inactivating NF-kappaB and STAT3 pathways, and ultimately, leading to decreased levels of collagen I, MMP-1, and MMP-13. Prednisone 15-25 interleukin 6 Homo sapiens 103-107 28537665-9 2017 Furthermore, overexpression of miR-138 suppressed the protein levels of p65, COX-2 and IL6 in human OA chondrocytes and chondrogenic SW1353 cells. mir-138 31-38 interleukin 6 Homo sapiens 87-90 31567972-6 2019 Levels of IL-6, IL-7, and monocyte chemoattractant protein 1 were higher with 5-aminosalicylic acid (5-ASA) + Azathioprine therapy than controls (P < .05). Azathioprine 110-122 interleukin 6 Homo sapiens 10-14 28372647-11 2017 Plasma IL-6 level at the end of surgery was significantly lower in the landiolol group compared with the control group, but the other plasma cytokines levels were similar between the two groups during the entire study period. landiolol 71-80 interleukin 6 Homo sapiens 7-11 27736317-6 2017 OACs in coculture with AMs expressed significantly higher levels of MMP-1, MMP-3, MMP-9, MMP-13, IL-1beta, TNF-alpha, IL-6, IL-8, and IFN-gamma compared to OACs in mono-culture, indicating that proinflammatory macrophages may intensify the abnormal matrix degradation and cytokine secretion already associated with OACs. oacs 0-4 interleukin 6 Homo sapiens 118-122 31005727-8 2019 In presence of OSCC an increased concentration of IL-8(p = 0.004), IL-6(p = 0.005), VEGF(p = 0.014), MIP-1ss(p = 0.033), IP-10(p = 0.047), IL-1beta(p = 0.049) was observed; conversely the concentration of IFN-gamma(p = 0.036) and IL-5(P = 0.048) decreased. oscc 15-19 interleukin 6 Homo sapiens 67-71 27832944-9 2017 The results indicated that CAPE inhibits LPS-induced IL-6, IL-8, iNOS, and COX-2 production in a dose-dependent manner. caffeic acid phenethyl ester 27-31 interleukin 6 Homo sapiens 53-57 27237221-13 2017 Levels of inflammatory markers were elevated, and there were no significant differences between ICA and CFA groups, with an exception of interleukin 6 (IL-6) levels, which was higher in the ICA group (3.2+-2.5 ng/L vs. 1.8+-1.3 ng/L, p<0.05). isocyanic acid 190-193 interleukin 6 Homo sapiens 137-150 27237221-13 2017 Levels of inflammatory markers were elevated, and there were no significant differences between ICA and CFA groups, with an exception of interleukin 6 (IL-6) levels, which was higher in the ICA group (3.2+-2.5 ng/L vs. 1.8+-1.3 ng/L, p<0.05). isocyanic acid 190-193 interleukin 6 Homo sapiens 152-156 28438224-8 2017 IL-6 was significantly higher in MSA-C patients with the lowest grade of HCBS compared with those with the highest grade. hcbs 73-77 interleukin 6 Homo sapiens 0-4 28428736-10 2017 Blood IL-6 increased significantly after exercise only in subjects supplemented with fructose. Fructose 85-93 interleukin 6 Homo sapiens 6-10 31250861-3 2019 In addition, DPA also inhibited the abnormal production and mRNA expression of pro-inflammatory cytokines, namely tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 and improved the production and expression of an anti-inflammatory cytokine, IL-10. docosapentaenoic acid 13-16 interleukin 6 Homo sapiens 176-180 27988893-3 2017 Here, we demonstrate a new IPC compound, N-acetylglutaminoyl-S-farnesyl-L-cysteine (SIG-1191), which inhibits UVB-induced inflammation blocking pro-inflammatory cytokine interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) production. ipc 27-30 interleukin 6 Homo sapiens 170-183 27245499-6 2017 The kynurenine pathway is also critically regulated by cytokines, and, indeed, the pro-inflammatory cytokines interleukin (IL)-1beta and IL-6 are elevated in schizophrenia and bipolar disorder and stimulate the production of kynurenic acid. Kynurenic Acid 225-239 interleukin 6 Homo sapiens 137-141 31396302-9 2019 IL-6 was an independent predictor of L-arginine/ADMA, VEGF-A of ADMA, G-CSF of L-arginine/SDMA, and GM-CSF of L-citrulline and SDMA. N,N-dimethylarginine 48-52 interleukin 6 Homo sapiens 0-4 27286739-3 2016 In this study, we examine the expression of the interleukin-6/Janus kinase/STAT3 (IL-6/JAK/STAT3) pathway components in PA and ca-ex-PA. ca-ex-pa 127-135 interleukin 6 Homo sapiens 48-61 27286739-3 2016 In this study, we examine the expression of the interleukin-6/Janus kinase/STAT3 (IL-6/JAK/STAT3) pathway components in PA and ca-ex-PA. ca-ex-pa 127-135 interleukin 6 Homo sapiens 82-86 27988893-3 2017 Here, we demonstrate a new IPC compound, N-acetylglutaminoyl-S-farnesyl-L-cysteine (SIG-1191), which inhibits UVB-induced inflammation blocking pro-inflammatory cytokine interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) production. ipc 27-30 interleukin 6 Homo sapiens 185-189 29382220-6 2019 It was found that gracicleistanthoside (5) and uridine (7) remarkably down-regulated the TNF-alpha-induced synthesis of interleukin-6 (IL-6), a pro-inflammatory cytokine associated with cutaneous inflammation, in HaCaT cells. Uridine 47-54 interleukin 6 Homo sapiens 120-133 27905107-5 2017 Subsequently, PAC suppress the LPS-induced secretion of interleukin-6 (IL-6) and IL-12p70, while enhancing secretion of IL-10. Proanthocyanidins 14-17 interleukin 6 Homo sapiens 56-69 27905107-5 2017 Subsequently, PAC suppress the LPS-induced secretion of interleukin-6 (IL-6) and IL-12p70, while enhancing secretion of IL-10. Proanthocyanidins 14-17 interleukin 6 Homo sapiens 71-75 27161894-11 2016 Serum concentration of IL-6 and CRP decreased from 8.1 +- 6.6 pg/mL to 4.6 +- 4.1 pg/mL (p < 0.05) and from 0.50 (0.10-1.27) mg/dL to 0.28 (0.09-0.62) mg/dL (p < 0.05), respectively only in the cholecalciferol group. Cholecalciferol 200-215 interleukin 6 Homo sapiens 23-27 29382220-6 2019 It was found that gracicleistanthoside (5) and uridine (7) remarkably down-regulated the TNF-alpha-induced synthesis of interleukin-6 (IL-6), a pro-inflammatory cytokine associated with cutaneous inflammation, in HaCaT cells. Uridine 47-54 interleukin 6 Homo sapiens 135-139 31213851-0 2019 Deferoxamine-induced high expression of TfR1 and DMT1 enhanced iron uptake in triple-negative breast cancer cells by activating IL-6/PI3K/AKT pathway. Deferoxamine 0-12 interleukin 6 Homo sapiens 128-132 27779898-7 2016 The active form of VD is 1,25(OH)2D3 that produces biological effects via the nuclear hormone receptor named VD receptor (VDR), which may interfere with the immune cells and macrophages leading to the suppression of the inflammatory process by decreasing the release of TNF-alpha, IL-1, IL-6, and IL-8, IL-12, and IL-23. Calcitriol 25-36 interleukin 6 Homo sapiens 287-291 27927986-4 2017 Moreover, GlcN suppressed LPS-induced up-regulation of COX-2, IL-6, and TNF-alpha mRNAs under 25 mm glucose conditions yet did not inhibit up-regulation under 5 mm glucose conditions. Glucosamine 10-14 interleukin 6 Homo sapiens 62-66 31213851-9 2019 For the possible regulatory mechanism, we found that DFO treatment could promote a high expression level of IL-6 in aggressive MDA-MB-231 cells. Deferoxamine 53-56 interleukin 6 Homo sapiens 108-112 31213851-11 2019 Conclusion: We demonstrated that DFO could upregulate expression of TfR1 and DMT1 , which enhanced iron uptake via activating IL-6/PI3K/AKT signaling pathway in aggressive TNBCs. Deferoxamine 33-36 interleukin 6 Homo sapiens 126-130 28114138-13 2017 CONCLUSIONS: Even though pGSN was inversely correlated with age, CRP and IL-6, suggesting that inflammation may influence pGSN, lower pGSN levels were not associated with hospitalization, all-cause and cardio-vascular mortality in this patient population. pgsn 25-29 interleukin 6 Homo sapiens 73-77 28480382-8 2017 The paired analysis comparing pre- and post-exercise, with and without caffeine showed that IL-6 presented higher post-exercise values in the GC group. Caffeine 71-79 interleukin 6 Homo sapiens 92-96 28480382-11 2017 However, the caffeine effect on IL-6 level and muscle hypertrophy increase should be better investigated in future studies. Caffeine 13-21 interleukin 6 Homo sapiens 32-36 31156337-0 2019 TNF-alpha and IL-6 as Biomarkers of Impaired Lung Functions in Dimethylacetamide Exposure. dimethylacetamide 63-80 interleukin 6 Homo sapiens 14-18 27664570-3 2016 We found that AZM down-regulated CD80, CD86, and HLA-DR expression in lipopolysaccharide (LPS)-stimulated DCs and suppressed interleukin (IL)-6, IL-10, IL-12, and tumor necrosis factor-alpha production in these cells. Azithromycin 14-17 interleukin 6 Homo sapiens 125-143 27286739-8 2016 CONCLUSION: The IL-6/JAK/STAT3 pathway is overexpressed in PA, and this overexpression was even more pronounced in ca-ex-PA, with a shift in the JAKs mediating STAT3 phosphorylation. ca-ex-pa 115-123 interleukin 6 Homo sapiens 16-20 27286739-9 2016 Future studies are needed to clarify whether PA and ca-ex-PA could be treated with targeted therapy directed against components of the IL-6/JAK/STAT3 pathway. ca-ex-pa 52-60 interleukin 6 Homo sapiens 135-139 31053727-7 2019 Furthermore, transfected chondrocytes with miR-125b mimic in the presence of IL-1beta also showed marked inhibition in the secretion of several proinflammatory cytokines, chemokines and growth factors including IL-6, IL-8, INF-gamma, TGF-beta1, IGFBP-1 and PGDF-BB. mir-125b 43-51 interleukin 6 Homo sapiens 211-215 27566315-9 2016 The serum IL-6 level was correlated with the plasma concentration of oxycodone and inversely with the metabolic ratio to noroxycodone. noroxycodone 121-133 interleukin 6 Homo sapiens 10-14 27693124-11 2016 In conclusion, rhEndostatin inhibited HSF proliferation via G0/G1 and/or G2/M phase arrest of the cell cycle, which was partially due to the down-regulation of cyclinD1, CDK4 and PCNA. rhendostatin 15-27 interleukin 6 Homo sapiens 38-41 26491028-9 2016 IL-6 levels significantly increased the risperidone-induced expression of AKT1, DICER1, DROSHA, and COMT mRNA. Risperidone 40-51 interleukin 6 Homo sapiens 0-4 28028949-0 2016 Clarithromycin Decreases IL-6 Concentration in Serum and BAL Fluid in Patients with Cryptogenic Organizing Pneumonia. Clarithromycin 0-14 interleukin 6 Homo sapiens 25-29 28028949-9 2016 Clarithromycin treatment resulted in a significantly lower mean value of serum IL-6 responders than non-responders. Clarithromycin 0-14 interleukin 6 Homo sapiens 79-83 28028949-10 2016 CONCLUSIONS: In COP patients, response to clarithromycin treatment was associated with decreases in serum concentrations of IL-6, IL-8 and TGF-beta, and of rations, and of the BAL-f concentration of IL-6. Clarithromycin 42-56 interleukin 6 Homo sapiens 124-128 28028949-10 2016 CONCLUSIONS: In COP patients, response to clarithromycin treatment was associated with decreases in serum concentrations of IL-6, IL-8 and TGF-beta, and of rations, and of the BAL-f concentration of IL-6. Clarithromycin 42-56 interleukin 6 Homo sapiens 199-203 27693124-12 2016 These findings suggest that rhEndostatin may reduce scar hypertrophy in vivo via inhibition of HSF proliferation and may be a novel agent for HS treatment. rhendostatin 28-40 interleukin 6 Homo sapiens 95-98 31092431-8 2019 CONCLUSION: Plasmatic doses of ASA and celecoxib altered the expression of IL6 and the gene expression of chemokines (ligands and receptors) and cytokines in a dose- and time-dependent manner. Celecoxib 39-48 interleukin 6 Homo sapiens 75-78 27517515-0 2016 Mangiferin inhibits lipopolysaccharide-induced production of interleukin-6 in human oral epithelial cells by suppressing toll-like receptor signaling. mangiferin 0-10 interleukin 6 Homo sapiens 61-74 27353644-4 2016 RESULTS: The urinary IL-6 concentrations increased from uACR <10 (97.2+-26.4pg/ml) to uACR 10-30 (113.6+-28.0pg/ml) and to uACR >30mg/g creatinine (163.5+-25.6pg/ml) (P<0.05 and P<0.001, respectively) patients. uacr 56-60 interleukin 6 Homo sapiens 21-25 30867059-19 2019 Administration of hADSCs to the mice that received siltuximab (human IL-6 blocker) did not cause an influx of the M2 macrophages, and the number of capillaries formed was at the level of the control group, as in contrast to the mice that received only the hADSCs. hadscs 18-24 interleukin 6 Homo sapiens 69-73 27697591-6 2016 Finally, our results showed that pharmacological inhibitors for MAPK and NFkappaB significantly reduced IL-6 secretion stimulated by Pg LPS and IL-1beta, indicating that the MyD88-dependent MAPK and NFkappaB signaling pathways are essential for the upregulation of proinflammatory cytokine expression by Pg LPS and IL-1beta. pg 133-135 interleukin 6 Homo sapiens 104-108 30682488-8 2019 Mechanistically, our studies demonstrated that evodiamine inhibited the activation of IL-6 -induced STAT3 signaling activation, and the inhibitory effect was likely due to the upregulation of phosphatase shatterproof 2 (SHP-2), a negative feedback regulator of IL-6/STAT3. evodiamine 47-57 interleukin 6 Homo sapiens 86-90 27793087-12 2016 Presence of lipoproteins was found to modulate the MAMP-induced cytokine release by primary human monocytes measured as changes in the release of IL-6, TNFalpha, GM-CSF and IFNgamma. Acebutolol 51-55 interleukin 6 Homo sapiens 146-150 27776166-7 2016 Furthermore, GlcN suppressed the expression of proinflammatory cytokine genes (such as IL-6, IL-8, IL-24 and TNF-alpha genes). Glucosamine 13-17 interleukin 6 Homo sapiens 87-91 26794005-11 2016 Consistent with this increase in STAT3 phosphorylation, pre-treatment of HepG2 cells with PTE enhanced IL-6-induced STAT3 phosphorylation and attenuated oleic acid-induced steatosis in a STAT3-dependent manner. pte 90-93 interleukin 6 Homo sapiens 103-107 27314537-9 2016 Following treatment with bath-PUVA therapy, we observed a significant decrease in TNF-alpha and IL-6 mRNA levels in PBMCs (p=0.031, p=0.035, respectively). puva 30-34 interleukin 6 Homo sapiens 96-100 30682488-8 2019 Mechanistically, our studies demonstrated that evodiamine inhibited the activation of IL-6 -induced STAT3 signaling activation, and the inhibitory effect was likely due to the upregulation of phosphatase shatterproof 2 (SHP-2), a negative feedback regulator of IL-6/STAT3. evodiamine 47-57 interleukin 6 Homo sapiens 261-265 30682488-9 2019 Blockage of SHP-2 through small interference RNA (siRNA) abolished the evodiamine -induced IL-6/STAT3 signaling inhibition. evodiamine 71-81 interleukin 6 Homo sapiens 91-95 28352827-1 2016 This study retrospectively analyzed the efficacy of hydrogen water in the treatment of neonatal hypoxic-ischemic encephalopathy (HIE) and its effect on serum neuron-specific enolase (NSE), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) levels. hydrogen water 52-66 interleukin 6 Homo sapiens 189-202 30682488-11 2019 In summary, our results implied evodiamine as a promising anti-cancer agent in the treatment of CCA, and the mechanism is likely due to the inhibition of IL-6/STAT3 signaling with upregulating the expression levels of SHP-2. evodiamine 32-42 interleukin 6 Homo sapiens 154-158 26491028-12 2016 Increased IL-6 levels may prime the expression of genes (AKT1, DICER1, DROSHA, and COMT) in response to risperidone, suggesting that cytokine x treatment x gene interactions may improve cell function profiles. Risperidone 104-115 interleukin 6 Homo sapiens 10-14 26616855-6 2016 Suppression of STAT3, MAPK and Akt pathways were also observed as a consequence of diacerein-mediated upstream inhibition of IL-6/IL-6R. diacerein 83-92 interleukin 6 Homo sapiens 125-129 30548082-7 2019 Hinokitiol could inhibited NF-kappaB activation and IL-6 and TNF-alpha upregulation in liver tissues. beta-thujaplicin 0-10 interleukin 6 Homo sapiens 52-56 26616855-11 2016 Taken together, diacerein offered a novel blueprint for cancer therapy by hampering IL-6/IL-6R/STAT3/MAPK/Akt network. diacerein 16-25 interleukin 6 Homo sapiens 84-88 27150832-2 2016 Glycogen availability is a potent stimulator of IL-6 secretion. Glycogen 0-8 interleukin 6 Homo sapiens 48-52 27729872-8 2016 In summary, this study showed that muscle IL-6, IL-8, and MCP-1 mRNA expression after 75-km cycling was unrelated to glycogen depletion and muscle damage, with change in muscle glycogen related to plasma IL-6, and changes in serum myoglobin and cortisol related to the chemotactic cytokines IL-8 and MCP-1. Glycogen 177-185 interleukin 6 Homo sapiens 204-208 30548082-12 2019 Moreover, hinokitiol attenuated H/R-stimulated NF-kappaB activation and reduced the levels of IL-6 and TNF-alpha mRNAs, suggesting that hinokitiol can protect hepatocytes from H/R injury. beta-thujaplicin 10-20 interleukin 6 Homo sapiens 94-98 30548082-12 2019 Moreover, hinokitiol attenuated H/R-stimulated NF-kappaB activation and reduced the levels of IL-6 and TNF-alpha mRNAs, suggesting that hinokitiol can protect hepatocytes from H/R injury. beta-thujaplicin 136-146 interleukin 6 Homo sapiens 94-98 29336891-7 2019 DMEC showed a significant reduction of feed intake, ROS and NO, 3-NT, IL-6 and eNOS vs. DM (P < 0.05). dmec 0-4 interleukin 6 Homo sapiens 70-74 27481191-7 2016 Diketopiperazine suppressed the PolyP-mediated vascular barrier permeability, upregulation of inflammatory biomarkers, adhesion/migration of leukocytes, and activation and/or production of nuclear factor-kappaB, tumor necrosis factor-alpha, and interleukin-6. Diketopiperazines 0-16 interleukin 6 Homo sapiens 245-258 26891591-5 2016 Results indicated that some urolithins and ellagic acid were able to reduce the adhesion of THP-1 monocytes to human umbilical vein endothelial cells (HUVECs) and the secretion of a cellular adhesion molecule (sVCAM-1) and pro-inflammatory cytokine (IL-6). urolithins 28-38 interleukin 6 Homo sapiens 250-254 27145239-10 2016 LCFA (oleic acid) up-regulated tumor necrosis fator-alpha, monocyte chemoattractant-1 and interleukin-1beta while down-regulated IL-6 and IL-8 secretion to a higher extent than MCFA in mRNA and protein levels. lcfa 0-4 interleukin 6 Homo sapiens 129-133 27494773-7 2016 Whole blood from nilotinib-treated CML patients, demonstrated increased platelet adhesion ex vivo under flow, increased plasma soluble P- and E-selectin, sICAM-1, sVCAM-1, TNF-alpha, IL-6 levels and endogenous thrombin potential (ETP) levels in vivo, despite being on daily low-dose aspirin. nilotinib 17-26 interleukin 6 Homo sapiens 183-187 27140063-3 2016 EGC isolated from CD and control patients showed similar expression of glial markers and EGC-derived soluble factors (IL6, TGF-beta, proEGF, GSH) but CD EGC failed to increase IEB resistance and healing. (-)-Epigallocatechin 0-3 interleukin 6 Homo sapiens 118-121 27234962-7 2016 Furthermore, treatment with 24,25-[OH]2D3 increased IL-1beta, IL-6, and IL-8 expression by HepG2 cells. 24,25-Dihydroxyvitamin D 3 28-41 interleukin 6 Homo sapiens 62-66 30393274-8 2019 Cantharidin obviously inhibited the expression of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), and also the level of IL-6 and TNF-alpha in culture supernatants. Cantharidin 0-11 interleukin 6 Homo sapiens 50-63 26616855-0 2016 Diacerein-mediated inhibition of IL-6/IL-6R signaling induces apoptotic effects on breast cancer. diacerein 0-9 interleukin 6 Homo sapiens 33-37 26616855-5 2016 Further molecular investigations indicated that diacerein instigated apoptosis was associated with inhibition of IL-6/IL-6R autocrine signaling axis. diacerein 48-57 interleukin 6 Homo sapiens 113-117 26961818-6 2016 The results suggested that, compared with observed clinical data, changes in systemic exposure to multiple CYP substrates by anti-IL-6 treatment in virtual RA patients have been reasonably captured by the PBPK model, as manifested by modulations in area under plasma concentration versus time curves for midazolam, omeprazole, S-warfarin, and caffeine. Caffeine 343-351 interleukin 6 Homo sapiens 130-134 26794222-7 2016 RESULTS: Human corneal epithelial cells (HCEC) expressed the vitamin D receptor (VDR) and retinoid x receptor (RXR) and were responsive to 1,25- dihydroxyvitamin D3, as shown by induction of the 1,25- dihydroxyvitamin D3 responsive gene cyp-24A1 and slightly reduced abundance of IL-6 mRNA. Calcitriol 139-164 interleukin 6 Homo sapiens 280-284 26593276-5 2016 We found that lithium chloride (LiCl), a widely used GSK3 inhibitor and the mainstay treatment for bipolar disorder, reinforced the LPS adaptive response by enhancing both downregulation of pro-inflammatory genes (inducible nitric oxide synthase, interleukin 1beta, interleukin 6, tumor necrosis factor alpha), and upregulation of genes typically associated to anti-inflammatory functions (interleukin 10 and MRC1). Lithium Chloride 14-30 interleukin 6 Homo sapiens 266-308 30393274-8 2019 Cantharidin obviously inhibited the expression of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), and also the level of IL-6 and TNF-alpha in culture supernatants. Cantharidin 0-11 interleukin 6 Homo sapiens 65-69 26593276-5 2016 We found that lithium chloride (LiCl), a widely used GSK3 inhibitor and the mainstay treatment for bipolar disorder, reinforced the LPS adaptive response by enhancing both downregulation of pro-inflammatory genes (inducible nitric oxide synthase, interleukin 1beta, interleukin 6, tumor necrosis factor alpha), and upregulation of genes typically associated to anti-inflammatory functions (interleukin 10 and MRC1). Lithium Chloride 32-36 interleukin 6 Homo sapiens 266-308 26825457-6 2016 Furthermore, AZO more effectively reduced TSLP, IL-6, IL-8, and TNF-alpha levels than ZO-NP. anthrone 13-16 interleukin 6 Homo sapiens 48-52 30393274-8 2019 Cantharidin obviously inhibited the expression of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), and also the level of IL-6 and TNF-alpha in culture supernatants. Cantharidin 0-11 interleukin 6 Homo sapiens 138-142 30321637-7 2019 After treated by Tri-DAP or MDP, the levels of IL-6 and TNF-alpha in peripheral blood were significantly lower in preterm and term newborns when comparing to adults. L-Ala-gamma-D-Glu-meso-diaminopimelic acid 17-24 interleukin 6 Homo sapiens 47-51 26811545-9 2016 Concordantly, the ERK inhibitor U0126 significantly decreased IL1B-induced IL6, CXCL8, CCL2 and PTGS2 mRNA abundance; IL6, CXCL8, CCL2 and PGF2 alpha release; and NF-kappaB activation. U 0126 32-37 interleukin 6 Homo sapiens 75-78 26947457-5 2016 The new compound murrayakonine A (), O-methylmurrayamine A () and murrayanine () were proven to be the most active, efficiently inhibiting TNF-alpha and IL-6 release in a dose-dependent manner and showing decreased LPS induced TNF-alpha and IL-6 production in human PBMCs [corrected]. murrayanine 66-77 interleukin 6 Homo sapiens 153-157 26839145-8 2016 RESULTS: Patients with an IL6 rs2069837 G allele treated with FOLFIRI plus bevacizumab had an inferior PFS than those with the A/A genotype in TRIBE [9.4 vs. 11.1 months; HR = 1.53; 95% confidence interval (CI), 1.12-2.10; P = 0.004] and FIRE-3 (8.8 vs. 10.9 months; HR = 1.40; 95% CI, 1.06-1.85; P = 0.015). FOLFIRI regimen 62-69 interleukin 6 Homo sapiens 26-29 26947457-5 2016 The new compound murrayakonine A (), O-methylmurrayamine A () and murrayanine () were proven to be the most active, efficiently inhibiting TNF-alpha and IL-6 release in a dose-dependent manner and showing decreased LPS induced TNF-alpha and IL-6 production in human PBMCs [corrected]. murrayanine 66-77 interleukin 6 Homo sapiens 241-245 30584292-7 2018 The FEV1%, PImax, TNF-alpha, IL-6, and total CCQ score differed significantly in the FDBT group in the post-experimental period as compared to those in the SDBT group. fdbt 85-89 interleukin 6 Homo sapiens 29-33 26943970-8 2016 Most importantly, the activated microglia exposed to vitamin D3 had reduced expression of pro-inflammatory cytokines, IL-6, IL-12, and TNFalpha, and increased expression of IL-10. Cholecalciferol 53-63 interleukin 6 Homo sapiens 118-122 27399105-3 2016 Variant genotype (GG+GC) of the IL-6 -572C>G polymorphism was higher in the control group (P = 0.042).We observed that high GWG may be an important predictor factor for the afterward BW, being positively correlated with FM, TBW, BMR, metabolic age of the mothers, and negatively with the mother"s smoking status. tbw 227-230 interleukin 6 Homo sapiens 32-36 30193843-3 2018 The purpose of this double-blind, randomized study was therefore to investigate the effects of short-term DHEA administration (100 mg/day/4 weeks) on neuroendocrine (i.e., beta-endorphin and prolactin) and inflammatory (i.e., interleukin-6 and TNF-alpha) parameters in 10 young healthy female volunteers with regular sports practice. Dehydroepiandrosterone 106-110 interleukin 6 Homo sapiens 226-239 26986507-6 2016 Notably, we also found that miR-218 inhibited the expression of cell cycle regulatory protein cyclin A1 and invasion-related matrix metalloproteinase-9 protein induced by IL-6, and impeded the accelerative effect of IL-6 on LNCaP-IL-6+ cell proliferation, cell cycle progression and cell invasion. mir-218 28-35 interleukin 6 Homo sapiens 171-175 26986507-6 2016 Notably, we also found that miR-218 inhibited the expression of cell cycle regulatory protein cyclin A1 and invasion-related matrix metalloproteinase-9 protein induced by IL-6, and impeded the accelerative effect of IL-6 on LNCaP-IL-6+ cell proliferation, cell cycle progression and cell invasion. mir-218 28-35 interleukin 6 Homo sapiens 216-220 26986507-6 2016 Notably, we also found that miR-218 inhibited the expression of cell cycle regulatory protein cyclin A1 and invasion-related matrix metalloproteinase-9 protein induced by IL-6, and impeded the accelerative effect of IL-6 on LNCaP-IL-6+ cell proliferation, cell cycle progression and cell invasion. mir-218 28-35 interleukin 6 Homo sapiens 216-220 26986507-7 2016 Moreover, our results confirmed that miR-218 directly targets LGR4 and modulated the PI3K/Akt and Wnt/beta-catenin pathways in the LNCaP-IL-6+ cells. mir-218 37-44 interleukin 6 Homo sapiens 137-141 27007849-7 2016 The ER stress inducers thapsigargin and dithiothreitol trigger production of the pro-inflammatory cytokine IL-6 in a NOD1/2-dependent fashion. Dithiothreitol 40-54 interleukin 6 Homo sapiens 107-111 26453114-6 2016 In patients" plasma, a negative correlation associated IL-6 with circulating nitrites (r = -0.33). Nitrites 77-85 interleukin 6 Homo sapiens 55-59 26615574-6 2016 RESULTS: These results showed that farrerol inhibited LPS-induced IL-6 and IL-8 production in a dose dependent manner. farrerol 35-43 interleukin 6 Homo sapiens 66-70 26615574-9 2016 CONCLUSION: These results indicated that farrerol attenuated IL-6 and IL-8 production by inhibition of PI3K and AKT phosphorylation, resulting in an inhibition of NF-kappaB activation. farrerol 41-49 interleukin 6 Homo sapiens 61-65 26930567-5 2016 The active form of vitamin D (calcitriol) restored the SLE MAC phenotype towards that of healthy subjects with reduced IL-6 secretion, and normalised surface marker expression. Calcitriol 30-40 interleukin 6 Homo sapiens 119-123 30481900-7 2018 In all patients with TA, serum 25-OH-D correlated negatively with interleukin (IL)-6 (r=-0.296, P=0.023). 25-oh-d 31-38 interleukin 6 Homo sapiens 66-84 26329367-0 2016 Veratric Acid Inhibits LPS-Induced IL-6 and IL-8 Production in Human Gingival Fibroblasts. veratric acid 0-13 interleukin 6 Homo sapiens 35-39 26329367-6 2016 The results showed that veratric acid inhibited LPS-induced IL-6 and IL-8 production, as well as iNOS and COX-2 expression. veratric acid 24-37 interleukin 6 Homo sapiens 60-64 30481900-10 2018 The serum 25-OH-D level were negatively correlated with IL-6. 25-oh-d 10-17 interleukin 6 Homo sapiens 56-60 26572747-2 2016 We herein report the case of a 52-year-old woman presenting with severe multiple typical IHCA that regressed dramatically on treatment with fenofibrate, a PPAR agonist known to prevent IL6-induced inflammation experimentally and in humans. Fenofibrate 140-151 interleukin 6 Homo sapiens 185-188 30175388-6 2018 In THP-1 derived macrophages, AOH (1-20 microM) was found to suppress lipopolysaccharide (LPS)-induced NF-kappaB pathway activation, decrease secretion of the proinflammatory cytokines IL-8, IL-6, TNF-alpha and to induce secretion of the anti-inflammatory IL-10. alternariol 30-33 interleukin 6 Homo sapiens 191-195 26410851-5 2016 Our results demonstrated that piperine attenuated LPS-induced MPO activity, lung edema, and inflammatory cytokines TNF-alpha, IL-6, and IL-1beta production. piperine 30-38 interleukin 6 Homo sapiens 126-130 26878794-7 2016 PCB 126 exposure increased the expression of vascular inflammatory mediators, including interleukin (IL)-6, C-reactive protein, intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and IL-1alpha/beta, which were prevented by pretreatment with EGCG. Polychlorinated Biphenyls 0-3 interleukin 6 Homo sapiens 88-106 26454413-11 2016 Adding rIL-37 suppressed TNF-alpha, IL-1beta and IL-6 production in IS cells. ril-37 7-13 interleukin 6 Homo sapiens 49-53 30014900-4 2018 Our results demonstrate that PCCVC but not Calbuco ash particles induce cytotoxicity on human conjunctival epithelial cells viewed as a decrease in cell proliferation and the transmembrane mucin MUC1 expression; a pro-inflammatory response mediated by IL-6 and IL-8; and an imbalance of the redox environment leading to protein oxidative damage. pccvc 29-34 interleukin 6 Homo sapiens 252-256 26987326-3 2016 The present study was performed to assess the correlation between concentrations of IL-1beta, IL-6, IL-8, and TGF-beta1 in the serum with response to clarithromycin (CAM) treatment in patients with COP. Clarithromycin 150-164 interleukin 6 Homo sapiens 94-98 26987326-9 2016 We conclude that IL-6, IL-8, and TGF-beta1 may play a role in the pathogenesis of COP, as their decreased concentrations were associated with a positive response to CAM treatment. Clarithromycin 165-168 interleukin 6 Homo sapiens 17-21 26884290-7 2016 In turn, the effect of fenofibrate, alone or in combination with simvastatin, on TNF-alpha, interleukin-6, and hsCRP, but not on interleukin-1beta and MCP-1, was stronger in patients aged between 50 and 75 years, and correlated with an improvement in insulin sensitivity only in this age group. Fenofibrate 23-34 interleukin 6 Homo sapiens 92-105 26949603-7 2016 RESULTS: Triptolide inhibited the zymosan-induced release of IL-6, IL-8, and MCP-1 from HCFs in a concentration- and time-dependent manner. triptolide 9-19 interleukin 6 Homo sapiens 61-65 26949603-7 2016 RESULTS: Triptolide inhibited the zymosan-induced release of IL-6, IL-8, and MCP-1 from HCFs in a concentration- and time-dependent manner. Zymosan 34-41 interleukin 6 Homo sapiens 61-65 29964299-0 2018 Catechol derived from aronia juice through lactic acid bacteria fermentation inhibits breast cancer stem cell formation via modulation Stat3/IL-6 signaling pathway. catechol 0-8 interleukin 6 Homo sapiens 141-145 26531764-8 2016 CONCLUSION: In our study, naive patients starting tenofovir/emtricitabine or abacavir/lamivudine plus efavirenz showed after 48 weeks a significant and comparable decrease in serum concentrations of IL-6, TNF-alpha, ICAM-1, VCAM-1, Eselectin and P-selectin, while the mean level of hs-CRP did not change significantly in any group. abacavir 77-85 interleukin 6 Homo sapiens 199-203 26562044-9 2016 None of the other cytokine levels were associated with either cord blood or current blood mercury concentrations, except that cord blood mercury was negatively associated with IL-6. Mercury 137-144 interleukin 6 Homo sapiens 176-180 26677330-11 2015 CONCLUSION: These results demonstrate that serum levels of interleukin-6, interleukin-8, and macrophage inflammatory protein-1beta as potential blood biomarkers could be utilized to identify the responsiveness of patients to serotonin and norepinephrine reuptake inhibitor like milnacipran, or to identify those patients who may experience AEs strong enough to warrant discontinuation of treatment. aes 340-343 interleukin 6 Homo sapiens 59-72 29964299-10 2018 These findings support the novel utilization of catechol for breast cancer therapy via the Stat3/IL-6 signaling pathway. catechol 48-56 interleukin 6 Homo sapiens 97-101 29964299-12 2018 Catechol inhibited Stat3 signaling by reducing Stat3 expression and secreted IL-6, a CSC survival factor. catechol 0-8 interleukin 6 Homo sapiens 77-81 29964299-13 2018 These findings support the novel utilization of catechol for breast cancer therapy via Stat3/IL-6 signaling. catechol 48-56 interleukin 6 Homo sapiens 93-97 30064906-4 2018 In LPS-induced sepsis model in vivo, administration of KPT330 increased survival rate and ameliorated LPS-induced lung injury, with suppressed levels of TNF-alpha, IL-6 and HMGB1 in the circulation and decreased macrophage and PMN subpopulations in peritoneal cavity. selinexor 55-61 interleukin 6 Homo sapiens 164-168 26423306-8 2016 PHE/TYR was positively correlated with interleukin (IL)-1beta (r = 0.37, p = 0.011) and IL-6 (r = 0.33, p = 0.025). Phenylalanine 0-3 interleukin 6 Homo sapiens 88-92 27697238-10 2016 PHE significantly decreases large artery elasticity index and increases inflammatory IL-6 level. Phenylalanine 0-3 interleukin 6 Homo sapiens 85-89 30064906-5 2018 In vitro investigations showed that KPT330 dose-dependently inhibited LPS-triggered proinflammatory cytokines production including TNF-alpha, IL-6 and HMGB1 in macrophages. selinexor 36-42 interleukin 6 Homo sapiens 142-146 26808720-9 2016 (R)-(+)-limonene derivatives decreased IL-6 production from normal cells in media with or without LPS (30.2% and 13.9%, respectively), while (-)-alpha-pinene derivatives induced IL-6 (verbenone had the strongest effect, 60.2% and 29.1% above control, respectively). verbenone 184-193 interleukin 6 Homo sapiens 178-182 30064906-6 2018 Furthermore, KPT330 treatment significantly suppressed TNF-alpha and IL-6 mRNA expression and inhibited HMGB1 necleocytoplasmic translocation by inhibiting CRM1 distribution. selinexor 13-19 interleukin 6 Homo sapiens 69-73 26396142-6 2015 Mechanistic studies have shown that calcitriol-active form of vitamin D-influences inflammatory processes involved in cancer progression, including the enzyme cyclooxygenase 2, the NF-kappaB pathway, and the expression of the cytokines TNFalpha, IL1beta, IL6, IL8, IL17, and TGFbeta1. Calcitriol 36-46 interleukin 6 Homo sapiens 255-258 29663176-3 2018 Serum magnesium was inversely associated with many CVD risk factors including prevalent atrial fibrillation, lung function (FEV1) and markers of inflammation (IL-6), endothelial dysfunction (vWF) and cardiac dysfunction [NT-proBNP and cardiac troponin T (cTnT)]. Magnesium 6-15 interleukin 6 Homo sapiens 159-163 26453510-7 2015 In IL-32-induced macrophages, acteoside significantly reduced LPS-induced TNF-alpha, IL-1beta, IL-6, and IL-8 production. acteoside 30-39 interleukin 6 Homo sapiens 95-99 26590114-7 2015 Fisetin also inhibited the production of NO, PGE2 IL-1beta, IL-6, expression of iNOS and COX-2, and activation of NF-kappaB in HaCaT cells treated with TNF-alpha. fisetin 0-7 interleukin 6 Homo sapiens 60-64 30054832-6 2018 We demonstrated that cryptotanshinone, as a dual inhibitor of p-STAT5 and p-STAT3, can effectively block IL-6-mediated STAT3 activation and reverse BCR-ABL kinase-independent drug resistance. cryptotanshinone 21-37 interleukin 6 Homo sapiens 105-109 26407807-7 2015 Activation of AMPK, using two pharmacologically distinct compounds, AICAR or phenformin, significantly suppressed LPS- or IL-1beta-induced gene expression and secretion of pro-inflammatory cytokine IL-6, the chemokines IL-8 and MCP-1, and COX-2 and subsequent prostaglandin release from adipose tissue and skeletal muscle. Phenformin 77-87 interleukin 6 Homo sapiens 198-202 30151063-11 2018 The treatment of cells with linagliptin at all concentrations significantly inhibited the LPS-stimulated IL-6 and TNF-alpha production. Linagliptin 28-39 interleukin 6 Homo sapiens 105-109 26472707-5 2015 Results indicates that pretreatment with Cucurbitacins significantly reduced the pro-inflammatory cytokine (TNF-alpha, IL-1beta and IL-6) and attenuated iNOS and COX-2 expression in TLR 2/4 agonists-stimulated microglia. Cucurbitacins 41-54 interleukin 6 Homo sapiens 132-136 30110934-3 2018 The 2-(4-morpholinyl)-ethyl ester of CF3-substituted mollugin (compound 15c) showed good water solubility, improved metabolic and plasma stability, and greater inhibitory activity than mesalazine in both the TNF-alpha- and IL-6-induced colonic epithelial cell adhesion assays, suggesting that 15c is a potential anti-inflammatory agent. 2-(4-morpholinyl)-ethyl ester 4-33 interleukin 6 Homo sapiens 223-227 26566386-10 2015 TsV alone, at 50 and 100 mug/mL, did not induce peripheral blood mononuclear cell proliferation, but elicited the production and release of IL-6, a proinflammatory cytokine that plays an important role in innate and adaptive immune responses. (2r,6s,12z,13as,14ar,16as)-6-[(Tert-Butoxycarbonyl)amino]-14a-[(Cyclopropylsulfonyl)carbamoyl]-5,16-Dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-Hexadecahydrocyclopropa[e]pyrrolo[1,2-A][1,4]diazacyclopentadecin-2-Yl 4-Fluoro-2h-Isoindole-2-Carboxylate 0-3 interleukin 6 Homo sapiens 140-144 26473447-0 2015 The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression. AZD1208 75-82 interleukin 6 Homo sapiens 129-132 29388713-8 2018 Moreover, IL-6 was highly expressed in peripheral blood and colonic mucosa samples genotyped as CC compared to those in TT and TC groups, furthermore, IL-6 was highly expressed in peripheral blood and colonic mucosa samples from participants with enteritis than without enteritis, whereas let-7 was highly expressed in peripheral blood and colonic mucosa samples genotyped as TT and TC compared to those in CC groups. Technetium 127-129 interleukin 6 Homo sapiens 10-14 26381871-10 2015 1,25(OH)2D3 decreased intracellular free cholesterol and polarized macrophages to M2 phenotype with decreased expression of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6 under lipopolysaccharide stimulation. Calcitriol 0-11 interleukin 6 Homo sapiens 172-185 29388713-8 2018 Moreover, IL-6 was highly expressed in peripheral blood and colonic mucosa samples genotyped as CC compared to those in TT and TC groups, furthermore, IL-6 was highly expressed in peripheral blood and colonic mucosa samples from participants with enteritis than without enteritis, whereas let-7 was highly expressed in peripheral blood and colonic mucosa samples genotyped as TT and TC compared to those in CC groups. Technetium 127-129 interleukin 6 Homo sapiens 151-155 29388713-8 2018 Moreover, IL-6 was highly expressed in peripheral blood and colonic mucosa samples genotyped as CC compared to those in TT and TC groups, furthermore, IL-6 was highly expressed in peripheral blood and colonic mucosa samples from participants with enteritis than without enteritis, whereas let-7 was highly expressed in peripheral blood and colonic mucosa samples genotyped as TT and TC compared to those in CC groups. Technetium 383-385 interleukin 6 Homo sapiens 10-14 25600905-11 2015 Aerobic training alone or in combination with L-carnitine had favorable effect on serum Il-6 and Hs-CRP levels as markers of inflammation in studied subjects. Carnitine 46-57 interleukin 6 Homo sapiens 88-92 29388713-8 2018 Moreover, IL-6 was highly expressed in peripheral blood and colonic mucosa samples genotyped as CC compared to those in TT and TC groups, furthermore, IL-6 was highly expressed in peripheral blood and colonic mucosa samples from participants with enteritis than without enteritis, whereas let-7 was highly expressed in peripheral blood and colonic mucosa samples genotyped as TT and TC compared to those in CC groups. Technetium 383-385 interleukin 6 Homo sapiens 151-155 29113582-12 2018 CONCLUSIONS: In the human placenta, MgSO4 blocks the increase in the proteins levels of NF-kappaB, IL-6, ACTH, and NOS in response to inflammatory stimuli. Magnesium Sulfate 36-41 interleukin 6 Homo sapiens 99-103 26539118-9 2015 In addition, nuciferine decreased TNF-a, IL-6 and IL-8 as well as the siRNA PASK group. nuciferine 13-23 interleukin 6 Homo sapiens 41-45 30061611-7 2018 Co-administration of Fc-apelin significantly attenuated serum ALT elevation, diminished LPS-induced apoptosis and ROS production in the liver and in Huh-7 cells, mitigated hepatic macrophage infiltration, and reduced TNFalpha and IL-6 gene expression. fc-apelin 21-30 interleukin 6 Homo sapiens 230-234 26160521-10 2015 Furthermore, a heptane-soluble (non-polar) extract of DEP induced both IL-6 and CXCL8 release, whereas a PBS-soluble (highly polar) extract induced only IL-6. Heptanes 15-22 interleukin 6 Homo sapiens 71-75 29229421-2 2018 BA-25 (3-alpha-o-acetoxy-4beta-amino-11-oxo-24-norurs-12-ene) an amino analogue of beta-boswellic acid exhibited inhibition of TNF-alpha and IL-6 in THP-1 cells as demonstrated previously, however, the effect on principal inflammatory mediators such as cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) and the pathways that mediate this function remains unknown. boswellic acid 83-102 interleukin 6 Homo sapiens 141-145 29435996-9 2018 The IL-6 plasma concentration was lower in the CECC group at 24 hours (P = 0.026, vs. MiECC). cecc 47-51 interleukin 6 Homo sapiens 4-8 26622531-5 2015 The overexpression of miR-181b resulted in the induction of an increment in interleukin (IL)-6 levels. mir-181b 22-30 interleukin 6 Homo sapiens 76-94 26196837-7 2015 We found, however, a significant association between EA levels and IL-6 concentrations, when newly changing EA levels were referred to subsequent changes in IL-6 concentrations (P < 0.05). ea 53-55 interleukin 6 Homo sapiens 67-71 26196837-7 2015 We found, however, a significant association between EA levels and IL-6 concentrations, when newly changing EA levels were referred to subsequent changes in IL-6 concentrations (P < 0.05). ea 108-110 interleukin 6 Homo sapiens 67-71 26196837-8 2015 Increasing EA levels were followed by a 90% increase of subsequent IL-6 concentrations during the next 24 to 48 h, whereas decreasing/stable EA levels were associated with slightly decreasing IL-6 concentrations (P < 0.05). ea 11-13 interleukin 6 Homo sapiens 67-71 29881256-11 2018 Plasma IL-6 levels decreased significantly only in the DHA group. Docosahexaenoic Acids 55-58 interleukin 6 Homo sapiens 7-11 26690867-0 2015 Doxorubicin-Hyaluronan Conjugated Super-Paramagnetic Iron Oxide Nanoparticles (DOX-HA-SPION) Enhanced Cytoplasmic Uptake of Doxorubicin and Modulated Apoptosis, IL-6 Release and NF-kappaB Activity in Human MDA-MB-231 Breast Cancer Cells. dox-ha 79-85 interleukin 6 Homo sapiens 161-165 26079696-7 2015 Moreover, we detected increased levels of interleukin (IL)-6 and IL-8 released in the 3 aldehyde exposure groups. Aldehydes 88-96 interleukin 6 Homo sapiens 42-60 29875665-10 2018 The GLPG and/or SHB treatments restored the inhibitory effects of acetate on IL-6 and IL-8 production and the inhibitory effects of butyrate or propionate on IL-6 production, but not on IL-8. Propionates 144-154 interleukin 6 Homo sapiens 158-162 29496671-6 2018 ERK1/2 reactivation in ibrutinib-treated BTKCys481Ser cells was accompanied by release of many prosurvival and inflammatory cytokines, including interleukin-6 (IL-6) and IL-10 that were also blocked by ERK1/2 inhibition. ibrutinib 23-32 interleukin 6 Homo sapiens 145-158 26177100-5 2015 Our second aim was to find a possible association between ACE gene polymorphism and inflammatory mediators (as interleukin (IL)-6) and/or cellular cytotoxicity induced by serum nitrite (as a breakdown product of the cytotoxic nitric oxide) in vitiligo patients. Nitrites 177-184 interleukin 6 Homo sapiens 111-129 29496671-6 2018 ERK1/2 reactivation in ibrutinib-treated BTKCys481Ser cells was accompanied by release of many prosurvival and inflammatory cytokines, including interleukin-6 (IL-6) and IL-10 that were also blocked by ERK1/2 inhibition. ibrutinib 23-32 interleukin 6 Homo sapiens 160-164 29715108-0 2018 2-Phenylnaphthyridin-4-one Derivative LYF-11 Inhibits Interleukin-6-mediated Epithelial-to-Mesenchymal Transition via the Inhibition of JAK2/STAT3 Signaling Pathway in MCF-7 Cells. LYF-11 0-26 interleukin 6 Homo sapiens 54-67 25929446-4 2015 Phloretin treatment decreased the production of IL-6, IL-8, CCL5, MDC, and TARC. Phloretin 0-9 interleukin 6 Homo sapiens 48-52 25852008-3 2015 Differentiated C2C12 myotubes treated with l-C14, C16, C18, and C18:1 carnitine displayed dose-dependent increases in IL-6 production with a concomitant rise in markers of cell permeability and death, which was not observed for shorter chain lengths. Carnitine 70-79 interleukin 6 Homo sapiens 118-122 29715108-0 2018 2-Phenylnaphthyridin-4-one Derivative LYF-11 Inhibits Interleukin-6-mediated Epithelial-to-Mesenchymal Transition via the Inhibition of JAK2/STAT3 Signaling Pathway in MCF-7 Cells. LYF-11 38-44 interleukin 6 Homo sapiens 54-67 29715108-8 2018 LYF-11 effectively inhibited IL-6-induced EMT phenotype and tumor-initiating ability via the inhibition of Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway. LYF-11 0-6 interleukin 6 Homo sapiens 29-33 25824337-9 2015 On the basis of our results, we concluded that calcitriol abrogated the IL6-induced aggressive tumor behavior and MDSC recruitment to inhibit esophageal tumor promotion. Calcitriol 47-57 interleukin 6 Homo sapiens 72-75 29228352-6 2018 Exposure of VSMCs to uraemic serum or recombinant TNF-alpha lead to a strong upregulation of IL-6 mRNA expression and protein secretion, which was mediated by activator protein 1 (AP-1)/c-FOS-pathway signalling. vsmcs 12-17 interleukin 6 Homo sapiens 93-97 25746333-9 2015 We also found that lower viral replication after LiCl treatment was associated with the reduced mRNA levels of pro-inflammatory IL-8, IL-6, IL-1 beta, tumor necrosis factor alpha and decreased NF-kappaB nuclear translocation. Lithium Chloride 49-53 interleukin 6 Homo sapiens 134-138 29223817-11 2018 IL-6 was associated negatively with systolic blood pressure, pulse pressure and HDL, and positively associated with TG, Tc/HDL and LDL/HDL. Technetium 120-122 interleukin 6 Homo sapiens 0-4 25662545-0 2015 Effects of glucosamine-chondroitin combination on synovial fluid IL-1beta, IL-6, TNF-alpha and PGE2 levels in internal derangements of temporomandibular joint. Glucosamine 11-22 interleukin 6 Homo sapiens 75-79 25662545-14 2015 CONCLUSIONS: In conclusion, these results might suggest that glucosamine-chondroitin combination significantly increases the MMO and decreases the synovial fluid IL1beta and IL6 levels in internal derangements of TMJ compared to tramadol. Glucosamine 61-72 interleukin 6 Homo sapiens 174-177 29467509-4 2018 After activation, both pro-inflammatory and anti-inflammatory cytokines were down-regulated at the mRNA level and certain cytokines (IL-1beta, IL-6 and IL-10) were decreased in the cell supernatant with the addition of magnesium. Magnesium 219-228 interleukin 6 Homo sapiens 143-147 25619393-8 2015 Pretreatment of the cells with DTT (500 mumol/L) or GSH (500 mumol/L) eliminated the inhibitory effects of bigelovin on the IL-6-induced and the constitutive STAT3 activation. Dithiothreitol 31-34 interleukin 6 Homo sapiens 124-128 26122215-4 2015 Deficiency of vitamin B1 may cause beriberi, dysfunction of the nervous system, neuroinflammation, T cell infiltration, chemokine CCL2 activation, over expression of proinflammatory cytokines, such as IL-1, TNF, IL-6, and arachidonic acid products, and induces expression of CD40 by the microglia and CD40L by astrocytes which provoke the death of neurons. Thiamine 14-24 interleukin 6 Homo sapiens 212-216 25659498-11 2015 AMPK activators AICAR, phenformin and A769662 significantly decreased IL-6 and IL-8 stimulated by LPS, flagellin and poly(I:C). Phenformin 23-33 interleukin 6 Homo sapiens 70-74 25499441-6 2015 Mangiferin treatment attenuated the expressions of TXNIP and NLRP3 and reduced IL-1beta and IL-6 production, demonstrating its inhibitory effects on TXNIP/NLRP3 inflammasome activation. mangiferin 0-10 interleukin 6 Homo sapiens 92-96 25480923-7 2015 Enzyme activities of CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, and CYP3A4 were reduced upon 48-72 hours exposure to IL-6 in PHH and HepaRG. 4,5,6,7-tetrachlorophthalide 123-126 interleukin 6 Homo sapiens 115-119 25480923-7 2015 Enzyme activities of CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, and CYP3A4 were reduced upon 48-72 hours exposure to IL-6 in PHH and HepaRG. heparg 131-137 interleukin 6 Homo sapiens 115-119 25868343-2 2015 The effect of different concentrations of the polysaccharide on production of TNF-alpha, IL-1beta and IL-6 was studied. Polysaccharides 46-60 interleukin 6 Homo sapiens 102-106 26664829-14 2015 Differences in baseline CK and IL-6 plasma protein concentrations are associated with genetics, sex, ethnicity, and the use of oral contraceptives, caffeine, and protein supplements in this young and athletic population. Caffeine 148-156 interleukin 6 Homo sapiens 31-35 26113783-4 2015 In our study, we first found that, after CAS, the serum IL-1beta, IL-6, TGF-beta, and MMP-9 levels were significantly increased, but only MMP-9 level was elevated no less than 3 months. cas 41-44 interleukin 6 Homo sapiens 66-70 25227591-5 2015 Circadian use of low-dose, long-term prednisone, by using night-release formulations (ingested at 10 to 11 p.m.) especially in early RA patients, appears characterized by a significantly superior efficacy on decreasing morning stiffness and IL-6 serum levels, compared to conventional daytime immediate-release prednisone. Prednisone 37-47 interleukin 6 Homo sapiens 241-245 25227901-12 2015 [Lancet 2008;371:205-214] reported CAPRA-1, which documented that modified-release prednisone or prednisolone taken at bedtime led to lower morning stiffness and IL-6 levels compared to usual morning prednisone. Prednisone 83-93 interleukin 6 Homo sapiens 162-166 25281570-7 2014 The results demonstrated that, compared with controls, 24-h pretreatment with TNF-alpha, IL-6, or endothelin-1 increased reactivity and Ca(2+) sensitivity of HPAs as revealed by agonist challenges with 80 mM KCl, 1 muM serotonin (5-hydroxytryptamine), 30 nM U-46619, and 1 muM phorbol 12,13-dibutyrate. Phorbol 12,13-Dibutyrate 277-301 interleukin 6 Homo sapiens 89-93 25092526-8 2014 RESULTS: Mannan, beta-glucans (curdlan), chitosan, and zymosan induced the secretion of interleukin (IL)-1beta, IL-6, IL-23, IL-10, and tumor necrosis factor-alpha by PBMCs. Zymosan 55-62 interleukin 6 Homo sapiens 112-116 25283329-10 2014 Myriocin or fumonisin B1 significantly lowered these cytokine levels and suppressed the gene expression of TNF-alpha and MCP-1 in RAW and of IL-6 and MCP-1 in L1. fumonisin B1 12-24 interleukin 6 Homo sapiens 141-145 24346482-10 2014 pHEs were also characterized by higher interleukin-6 levels and a slightly higher neuronal density . Phenylalanine 0-4 interleukin 6 Homo sapiens 39-52 25255717-9 2014 RESULTS: Fibrocytes did not affect ASMC proliferation and expression of TGF-beta1, eotaxin, alpha-SMA and MLCK; however, ASMC production of IL-8 and IL-6 was increased in the co-culture and transwell culture by FC. asmc 121-125 interleukin 6 Homo sapiens 149-153 25255717-10 2014 ASMC treated with FCCM were immunopositive for IL-8/IL-6 and produced more IL-8/IL-6. asmc 0-4 interleukin 6 Homo sapiens 52-56 25255717-10 2014 ASMC treated with FCCM were immunopositive for IL-8/IL-6 and produced more IL-8/IL-6. asmc 0-4 interleukin 6 Homo sapiens 80-84 25255717-11 2014 Furthermore, siRNA silencing of NF-kappaB-p65 or ERK1/2 in transwell cultures of asthmatic ASMC with normal subject FC decreased IL-8 and IL-6 production. asmc 91-95 interleukin 6 Homo sapiens 138-142 25255717-12 2014 CONCLUSIONS AND CLINICAL RELEVANCE: Fibrocytes promoted IL-8 and IL-6 production by ASMC, demonstrating a proinflammatory role for FC and a possible mechanism of the inflammatory phenotype in asthma. asmc 84-88 interleukin 6 Homo sapiens 65-69 25566616-8 2014 On the day of OPU levels of VEGF and IL-6 also significantly decreased (P < 0.05). opu 14-17 interleukin 6 Homo sapiens 37-41 25107704-4 2014 Archazolid (10nM) markedly reduced the release of pro-inflammatory (TNF-alpha, interleukin-6 and -8) but also of anti-inflammatory (interleukin-10) cytokines in monocytes stimulated with LPS, without affecting cell viability up to 1000nM. archazolid 0-10 interleukin 6 Homo sapiens 79-99 24590680-12 2014 Serum IL-6 significantly decreased in bLf-treated women and increased in ferrous sulphate-treated women. CHEMBL2024323 38-41 interleukin 6 Homo sapiens 6-10 25034231-11 2014 Importantly, suppression of osteoclastogenesis by GA was mediated through IL-6 inhibition. gambogic acid 50-52 interleukin 6 Homo sapiens 74-78 25216247-8 2014 RESULTS: ALD coating of MWCNTs with Al2O3 enhanced IL-1beta secretion by THP-1 and PBMC in vitro, yet reduced protein levels of IL-6, TNF-alpha, and OPN production by THP-1 cells. Aluminum Oxide 36-41 interleukin 6 Homo sapiens 128-132 24969824-17 2014 Urolithin C was the only compound inhibiting IL-6 production (at 0.625 muM 13.9+-2.2% of inhibition). urolithin C 0-11 interleukin 6 Homo sapiens 45-49 24796369-7 2014 In addition, the combined use of sabiporide and sodium bicarbonate had more profound reduction in interleukin (IL)-6 and IL-10, compared to sabiporide alone. sabiporide 33-43 interleukin 6 Homo sapiens 98-116 24796369-7 2014 In addition, the combined use of sabiporide and sodium bicarbonate had more profound reduction in interleukin (IL)-6 and IL-10, compared to sabiporide alone. Sodium Bicarbonate 48-66 interleukin 6 Homo sapiens 98-116 24793913-5 2014 Nucleotides such as ATP and UTP themselves also significantly increased IL-6 production in the cells. Uridine Triphosphate 28-31 interleukin 6 Homo sapiens 72-76 26267747-8 2015 Although the procedure induced a significant increase in high-sensitivity C-reactive protein, tumor necrosis factor alpha, and interleukin 6 levels, the values were significantly lower in the lipo-PGE1 group than those in the control group at 24 h after PCI (P<0.05). Alprostadil 197-201 interleukin 6 Homo sapiens 127-140 26342289-8 2015 RESULTS: Markers of TLR-activation increased following AZD8848 administration (CXCL10, TNFalpha, IL-6, IFNgamma). AZD8848 55-62 interleukin 6 Homo sapiens 97-101 25495336-7 2015 The LPS-induced increase in IL-6 and CXCL1 transcripts was attenuated by vitamin D3 (30 ng/mL). Cholecalciferol 73-83 interleukin 6 Homo sapiens 28-32 25495336-8 2015 Treatment with vitamin D3 (3-300 ng/mL) for 24 h reduced the LPS-evoked increase in PDL cell IL-6 protein by about 50%. Cholecalciferol 15-25 interleukin 6 Homo sapiens 93-97 25749777-10 2015 In addition, clarithromycin significantly alleviated IL-6-induced FoxA2 suppression and decreased MUC5AC expression in vitro (P<0.05). Clarithromycin 13-27 interleukin 6 Homo sapiens 53-57 26105582-8 2015 Fenofibrate, alone and in combination with pioglitazone, significantly decreased triacylglycerol, hs-CRP, IL-6, fetuin A and increased sirtuin 1 levels (P<0.001) which suggests that it can be used to delay the complications of obesity and T2DM. Fenofibrate 0-11 interleukin 6 Homo sapiens 106-110 25307474-8 2015 In addition, pectinase-driven hydrolysis in polysaccharides significantly increased TPS-induced Interleukin 6 (IL-6) production in macrophages. Polysaccharides 44-59 interleukin 6 Homo sapiens 96-109 25307474-8 2015 In addition, pectinase-driven hydrolysis in polysaccharides significantly increased TPS-induced Interleukin 6 (IL-6) production in macrophages. Polysaccharides 44-59 interleukin 6 Homo sapiens 111-115 25908506-7 2015 In stratified analyses, participants randomized to vitamin D3 who lost 5% to 10% of baseline weight, versus participants who gained weight/had no weight-loss, had significantly greater decreases in levels of IL6 compared with those randomized to placebo: absolute change -0.75 pg/mL (-17.2%), placebo versus -1.77 pg/mL (-37.3%), vitamin D, P = 0.004. Cholecalciferol 51-61 interleukin 6 Homo sapiens 208-211 25908506-11 2015 In conclusion, vitamin D3 supplementation in combination with weight-loss of at least 5% of baseline weight was associated with significant reductions in levels of IL6. Cholecalciferol 15-25 interleukin 6 Homo sapiens 164-167 26170842-10 2015 CONCLUSIONS: Peripheral blood levels of both hs-CRP and IL-6 were associated with TCFAs, as detected by OCT. tcfas 82-87 interleukin 6 Homo sapiens 56-60 25996641-4 2015 Phloretin inhibited levels of prostaglandin E2, decreased COX-2 expression, and suppressed IL-8, monocyte chemotactic protein 1, and IL-6 production. Phloretin 0-9 interleukin 6 Homo sapiens 133-137 25824337-0 2015 1alpha,25-Dihydroxyvitamin D3 Inhibits Esophageal Squamous Cell Carcinoma Progression by Reducing IL6 Signaling. Calcitriol 0-29 interleukin 6 Homo sapiens 98-101 25824337-7 2015 Supplementation with calcitriol attenuated the level of IL6, the induction of MDSCs, and the incidence of 4-NQO-induced invasive tumors. Calcitriol 21-31 interleukin 6 Homo sapiens 56-59 25087735-7 2015 While free ODN and PSA-TMC nanoparticles coated with scrambled ODNs did not have substantial impacts on the inflammatory response, the decoy ODN-coated PSA-TMC nanoparticles were able to reduce the secretion of interleukin-6 and interleukin-8, pro-inflammatory mediators of CF, by the epithelial cells, particularly at longer time points. trimethylchlorosilane 156-159 interleukin 6 Homo sapiens 211-224 25660969-3 2015 In this study, we investigated whether MAMP alone can induce IL-6 production in a human basophil cell line, KU812. 4-methylaminopyridine 39-43 interleukin 6 Homo sapiens 61-65 26018278-1 2015 OBJECTIVE: To explore the effects of different concentrations of putrescine on the proliferation, migration and apoptosis of human skin fibroblasts (HSF). Putrescine 65-75 interleukin 6 Homo sapiens 149-152 26018278-3 2015 RESULTS: Compared with the control cells, HSF cultured with 0.5, 1.0, 5.0, and 10 microg/ putrescine showed significantly increased cell proliferation (P<0.01), and the effect was the most obvious with 1 microg/ putrescine, whereas 500 and 1000 microg/ putrescine significantly reduced the cell proliferation (P<0.01); 50 and 100 microg/ did not obviously affect the cell proliferation (P>0.05). Putrescine 90-100 interleukin 6 Homo sapiens 42-45 26018278-3 2015 RESULTS: Compared with the control cells, HSF cultured with 0.5, 1.0, 5.0, and 10 microg/ putrescine showed significantly increased cell proliferation (P<0.01), and the effect was the most obvious with 1 microg/ putrescine, whereas 500 and 1000 microg/ putrescine significantly reduced the cell proliferation (P<0.01); 50 and 100 microg/ did not obviously affect the cell proliferation (P>0.05). Putrescine 215-225 interleukin 6 Homo sapiens 42-45 26018278-3 2015 RESULTS: Compared with the control cells, HSF cultured with 0.5, 1.0, 5.0, and 10 microg/ putrescine showed significantly increased cell proliferation (P<0.01), and the effect was the most obvious with 1 microg/ putrescine, whereas 500 and 1000 microg/ putrescine significantly reduced the cell proliferation (P<0.01); 50 and 100 microg/ did not obviously affect the cell proliferation (P>0.05). Putrescine 215-225 interleukin 6 Homo sapiens 42-45 26018278-6 2015 CONCLUSION: Low concentrations of putrescine can obviously enhance the proliferation ability and maintain normal migration ability of HSF in vitro, but at high concentrations, putrescine can obviously inhibit the cell migration and proliferation and induce cells apoptosis, suggesting the different roles of different concentrations of putrescine in wound healing. Putrescine 34-44 interleukin 6 Homo sapiens 134-137 25449047-11 2015 Levels of IL-6 in CTEPH patients were significantly higher than that in the controls. cteph 18-23 interleukin 6 Homo sapiens 10-14 24806810-5 2015 RESULTS: P. gingivalis LPS induced cytokine/chemokine (IL-6, IL-8, MCP-1, and GRO) protein production in HGFs, and this effect was suppressed by azithromycin at all concentrations tested. Azithromycin 145-157 interleukin 6 Homo sapiens 55-59 25614225-8 2015 Citrulline levels below the median at day +7 were associated with higher spontaneous production of IL-6 and TNF-alpha as well as higher in vitro stimulated production of IL-17A at day +21. Citrulline 0-10 interleukin 6 Homo sapiens 99-103 25435060-8 2015 An IQR increase in triclosan (TCS) was associated with 31% higher serum concentrations of IL-6 (p=0.007), a pro-inflammatory cytokine. Triclosan 19-28 interleukin 6 Homo sapiens 90-94 25435060-8 2015 An IQR increase in triclosan (TCS) was associated with 31% higher serum concentrations of IL-6 (p=0.007), a pro-inflammatory cytokine. Triclosan 30-33 interleukin 6 Homo sapiens 90-94 25675297-0 2015 p21-activated kinase 1 determines stem-like phenotype and sunitinib resistance via NF-kappaB/IL-6 activation in renal cell carcinoma. Sunitinib 58-67 interleukin 6 Homo sapiens 93-97 24993495-8 2014 Importantly, co-injection of IL-6 with the methionine analogue azido-homoalanine (AHA), to assess nascently synthesized proteins, revealed an increase in CREB containing AHA in the sciatic nerve 2 hrs post injection, indicating retrograde transport of nascently synthesized CREB. azidohomoalanine 170-173 interleukin 6 Homo sapiens 29-33 24901054-5 2014 We found that wogonin significantly decreased the secretion and expression of IL-6 and IL-1beta, reduced cell proliferation and nuclear expression of NF-kappaB in adenomas and surrounding tissues and promoted Nrf2 nuclear translocation in surrounding tissues, although overexpressed Nrf2 in tumor tissues was independent of wogonin administration. wogonin 14-21 interleukin 6 Homo sapiens 78-82 24932134-9 2014 RESULTS: In DU145 cells glucosamine reduced the N-glycosylation of gp130, decreased IL-6 binding to cells and impaired the phosphorylation of JAK2, SHP2 and STAT3. Glucosamine 24-35 interleukin 6 Homo sapiens 84-88 25675297-7 2015 Furthermore, nuclear factor-kappaB (NF-kappaB)/interleukin-6 (IL-6) activation was found to be responsible for PAK1-mediated stem-like phenotype following sunitinib treatment. Sunitinib 155-164 interleukin 6 Homo sapiens 47-60 29511456-11 2018 Our results demonstrated that expression of IL-6 and COX-2 were remarkably up-regulated in peripheral blood of DMCI patients compared with that in normal control group. dmci 111-115 interleukin 6 Homo sapiens 44-48 24172719-12 2014 Carbohydrate and caffeine consumption before endurance cycling significantly increased the IL-6 release and leukocytosis, and the additional ingredients in ED seem to have further augmented these responses. Caffeine 17-25 interleukin 6 Homo sapiens 91-95 29670468-8 2018 Results: SAA-stimulated levels of released IL-6, IL-8, and sVCAM-1 from HCAEC were significantly attenuated by methotrexate, fluvastatin, and etoricoxib. Etoricoxib 142-152 interleukin 6 Homo sapiens 43-47 24728972-8 2015 Both groups of CS patients (AS > 0 and AS = 0) had elevated trunk fat mass and IL-6 compared to reference values. as > 28-34 interleukin 6 Homo sapiens 82-86 26136131-5 2015 Simvastatin, fenofibrate, and simvastatin/fenofibrate combination therapy reduced monocyte release of TNF-alpha, inteleukin-1beta, interleukin-6, and MCP-1, with no difference between the treatment groups. Fenofibrate 13-24 interleukin 6 Homo sapiens 131-144 29027990-3 2018 In the present study, we demonstrated that GSIs, such as MK-0752 and RO4929097, inhibit breast tumor growth, but increase the breast cancer stem cell (BCSC) population in Notch3-expressing breast cancer cells, in a process that is coupled with IL6 induction and is blocked by the IL6R antagonist Tocilizumab (TCZ). 3-(4-((4-chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid 57-64 interleukin 6 Homo sapiens 244-247 26136131-5 2015 Simvastatin, fenofibrate, and simvastatin/fenofibrate combination therapy reduced monocyte release of TNF-alpha, inteleukin-1beta, interleukin-6, and MCP-1, with no difference between the treatment groups. Fenofibrate 42-53 interleukin 6 Homo sapiens 131-144 26136131-7 2015 The effect of simvastatin/fenofibrate combination therapy on monocyte release of interleukin-6 and MCP-1 was more pronounced in the male population. Fenofibrate 26-37 interleukin 6 Homo sapiens 81-94 23612780-5 2014 However, 100 nM of vitamin D3 significantly increased the release of IL-10, but suppressed the production of IL-2, IL-6, interferon gamma and TNF alpha in the culture supernatants of both groups. Cholecalciferol 19-29 interleukin 6 Homo sapiens 115-119 29027990-4 2018 IL6 induction results from inhibition of Notch3-Hey2 signaling through MK-0752. 3-(4-((4-chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid 71-78 interleukin 6 Homo sapiens 0-3 29216514-5 2018 The 50% Herceptin -NP conjugate group with short PEG modification to Herceptin showed the best reduction in immune cell uptake by 82% along with the reduction by >50% for proinflammatory cytokine response (TNF-alpha and IL-6). herceptin -np 8-21 interleukin 6 Homo sapiens 224-228 24664110-0 2014 The pneumococcal polysaccharide capsule and pneumolysin differentially affect CXCL8 and IL-6 release from cells of the upper and lower respiratory tract. Polysaccharides 17-31 interleukin 6 Homo sapiens 88-92 26247040-6 2015 Moreover, Det-DOC enhance the DC capacity to differentiate CD4(+)CD161(+)CD196(+) Th17-cells by upregulating IL-6 secretion. det-doc 10-17 interleukin 6 Homo sapiens 109-113 25281899-2 2014 In the present paper, it is shown that alpha7-specific agonists PNU282987 (130nM) or choline (1.6mM) attenuated the interleukin-6 (IL-6) production stimulated by bacterial lipopolysaccharide in monocyte-derived U937 and astrocyte-derived U373 cell lines. Choline 85-92 interleukin 6 Homo sapiens 116-129 29207166-7 2018 In addition, PPS treatment significantly inhibited HG-stimulated p38 MAPK and nuclear factor-kappaB activation, and reduced the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-6. Pentosan Sulfuric Polyester 13-16 interleukin 6 Homo sapiens 234-238 25281899-2 2014 In the present paper, it is shown that alpha7-specific agonists PNU282987 (130nM) or choline (1.6mM) attenuated the interleukin-6 (IL-6) production stimulated by bacterial lipopolysaccharide in monocyte-derived U937 and astrocyte-derived U373 cell lines. Choline 85-92 interleukin 6 Homo sapiens 131-135 24595168-4 2014 METHODOLOGY/PRINCIPAL FINDINGS: We have shown here that caffeine up-regulates the tumor suppressor proteins p16, p21, p53 and Cav-1, and reduces the expression/secretion of various cytokines (IL-6, TGF-beta, SDF-1 and MMP-2), and down-regulates alpha-SMA. Caffeine 56-64 interleukin 6 Homo sapiens 192-196 29260441-12 2018 DHA significantly decreased the high levels of IL-6, IL-18, and NF-kappaB expression observed in the HIV-1Tg EtOH group. Docosahexaenoic Acids 0-3 interleukin 6 Homo sapiens 47-51 24458953-6 2014 Interleukin-6, systolic blood pressure and standard deviation of wall thickness (WT) at baseline were independently positively associated with 18-FDG uptake (mean of maximum [MeanMax] TBR change over 6 months). Fluorodeoxyglucose F18 143-149 interleukin 6 Homo sapiens 0-13 24471583-0 2014 Electronic structure of H2S, SF2, and HSF and implications for hydrogen-substituted hypervalent sulfur fluorides. sulfur fluoride 96-112 interleukin 6 Homo sapiens 38-41 26155130-11 2014 CONCLUSIONS: Twelve weeks, calcitriol supplementation maintained IL-10, had no effects on hs- CRP and had no additional benefit compared to calcium carbonate in reducing serum IL-6 except in non-diabetics. Calcitriol 27-37 interleukin 6 Homo sapiens 176-180 25390653-5 2014 Simplexide induces a concentration- and time-dependent release of IL-6, CXCL8, TNF-alpha and IL-10 and increases the expression of IL6, CXCL8 and IL10 mRNA. simplexide 0-10 interleukin 6 Homo sapiens 66-70 25390653-5 2014 Simplexide induces a concentration- and time-dependent release of IL-6, CXCL8, TNF-alpha and IL-10 and increases the expression of IL6, CXCL8 and IL10 mRNA. simplexide 0-10 interleukin 6 Homo sapiens 131-134 25173056-0 2014 Low-level mercury in children: associations with sleep duration and cytokines TNF-alpha and IL-6. Mercury 10-17 interleukin 6 Homo sapiens 92-96 30205379-10 2018 Moreover, the PTX group showed a statistically significantly greater reduction in the serum levels of TNF-alpha, IL-6, IL-10, and 8-OHdG along with a statistically significant increase in the levels of BDNF and serotonin in comparison with the control group after the treatment. Pentoxifylline 14-17 interleukin 6 Homo sapiens 113-117 24609838-4 2014 In this article, we characterized hypoxia or P. gingivalis lipopolysaccharide (Pg LPS) induced tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1beta, and IL-6 expression by human periodontal ligament (hPDL) cells. pg 79-81 interleukin 6 Homo sapiens 164-168 24096876-10 2014 mRNA and protein expression of TNF-alpha, IL-8, and IL-6 in cells treated with DCA alone were up-regulated, and intra-cellular ROS and p-NF-kappaB p65 protein levels were also increased. Deoxycholic Acid 79-82 interleukin 6 Homo sapiens 52-56 28863031-4 2017 Magnesium has been shown to attenuate interleukin 6-mediated fever in animal models. Magnesium 0-9 interleukin 6 Homo sapiens 38-51 24509399-6 2014 RESULTS: IL- 6 increased significantly at both 5 and further at 24 h after surgery (3.2, 4.5 and 5.1 base-line, 5 and 24-h respectively), the IL-6 increase showed different patterns between the 2 groups; IL-6 was significantly increased in the control group of patients between preoperative baseline and 24 h after surgery (p = 0.008) also between 5 h and 24 h, (p = 0.006) after surgery while the AAI-group had only minor non-significant changes. aai 398-401 interleukin 6 Homo sapiens 9-14 24877691-6 2014 ZO-NP was found to inhibit the productions and mRNA expressions of inflammatory cytokines such as interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha on the phorbol 12-myristate 13-acetate plus A23187 (PMACI)-stimulated human mast cell line, HMC-1 cells. zo-np 0-5 interleukin 6 Homo sapiens 122-159 24844442-7 2014 Overall, our results indicate that Si50-induced IL-6 and CXCL8 responses in BEAS-2B cells were regulated through combined activation of several pathways, including NF-kappaBeta and p38/TACE/TGF-alpha/EGFR signalling. si50 35-39 interleukin 6 Homo sapiens 48-52 24693279-6 2014 Fenofibrate treatment at 10, 30, and 100 mg/kg for twenty-five days was found to be neuroprotective and improved cognitive impairment in MPTP-induced PD model as evident from behavioral, biochemical (MDA, GSH, TNF- alpha , and IL-6), immunohistochemistry (TH), and DNA fragmentation (TUNEL positive cells) studies. Fenofibrate 0-11 interleukin 6 Homo sapiens 227-231 29065971-2 2017 KHG26792 attenuated the Abeta-induced production of inflammatory mediators such as IL-6, IL-1beta, TNF-alpha, and nitric oxide. 3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride 0-8 interleukin 6 Homo sapiens 83-87 24232460-5 2013 Sunitinib promoted Th1-inducing and pro-inflammatory phenotypes (IL-12, IFN-gamma and IL-6) in DCs at the expense of Th2 inducing phenotype (IL-13) and regulatory phenotype (PD-L1, IDO). Sunitinib 0-9 interleukin 6 Homo sapiens 86-90 24951586-2 2014 Previous literature has implicated sphingolipids in the regulation of cytokines such as interleukin-6 (IL-6), but the specific sphingolipid pathways and mechanisms involved in inflammatory signaling need to be further elucidated. Sphingolipids 35-48 interleukin 6 Homo sapiens 88-101 24951586-2 2014 Previous literature has implicated sphingolipids in the regulation of cytokines such as interleukin-6 (IL-6), but the specific sphingolipid pathways and mechanisms involved in inflammatory signaling need to be further elucidated. Sphingolipids 35-48 interleukin 6 Homo sapiens 103-107 24951586-2 2014 Previous literature has implicated sphingolipids in the regulation of cytokines such as interleukin-6 (IL-6), but the specific sphingolipid pathways and mechanisms involved in inflammatory signaling need to be further elucidated. Sphingolipids 35-47 interleukin 6 Homo sapiens 88-101 24951586-2 2014 Previous literature has implicated sphingolipids in the regulation of cytokines such as interleukin-6 (IL-6), but the specific sphingolipid pathways and mechanisms involved in inflammatory signaling need to be further elucidated. Sphingolipids 35-47 interleukin 6 Homo sapiens 103-107 29115971-7 2017 However, local anaesthetics alone or in combination with morphine and/or MgSO4 reduced cell viability and increased the gene expression of IL-1beta, IL-6 or TNF-alpha. Magnesium Sulfate 73-78 interleukin 6 Homo sapiens 149-153 24880571-9 2014 Conversely, corticosterone, prednisone, and dexamethasone similarly inhibited cell invasion and expression of related genes, including MMP-9, VEGF, and IL-6, in GR-positive lines. Corticosterone 12-26 interleukin 6 Homo sapiens 152-156 24880571-9 2014 Conversely, corticosterone, prednisone, and dexamethasone similarly inhibited cell invasion and expression of related genes, including MMP-9, VEGF, and IL-6, in GR-positive lines. Prednisone 28-38 interleukin 6 Homo sapiens 152-156 28509297-0 2013 AP-VAS 2012 case report: a case of ANCA-negative pauci-immune crescentic glomerulonephritis associated with IL-6-producing adenosquamous cell carcinoma of the lung. ap-vas 0-6 interleukin 6 Homo sapiens 108-112 29068698-4 2017 Polyphenols influence the inflammatory process by controlling and inhibiting pro-inflammatory cytokines such as IL-1beta, IL-6, IL-8, and TNF-alpha, and cyclooxygenase-2 (COX-2) enzyme involved in the metabolism of arachidonic acid. Polyphenols 0-11 interleukin 6 Homo sapiens 122-126 22952245-3 2013 The objective of this study was to test whether concentrations of circulating inflammatory markers (C-reactive protein (CRP), interleukin-6 (IL-6) and interleukin 1 receptor antagonist (IL-1Ra)) were predictive for DCI following SAH. dci 215-218 interleukin 6 Homo sapiens 126-139 22952245-10 2013 In primary analyses the rate of change of IL-6 was associated with DCI (OR 2.3 (95% CI 1.1 to 5.0); p=0.03). dci 67-70 interleukin 6 Homo sapiens 42-46 23981042-6 2013 Also, that APDs inhibited the production of LPS-stimulated macrophages IL-6 and IL-8 suggests that risperidone and clozapine may inhibit inflammation. Risperidone 99-110 interleukin 6 Homo sapiens 71-75 23824148-6 2014 IL-1 alpha, IL-1beta and IL-6 levels were reduced by 1,25(OH) 2D3 at higher concentrations in all cell populations. (oh) 2d3 57-65 interleukin 6 Homo sapiens 25-29 29031393-9 2017 An analysis of possible relationships between DHA and the concentrations of different cytokines revealed negative correlation between maternal plasmatic IL-6 and DHA (higher plasmatic DHA corresponded to lower IL-6). Docosahexaenoic Acids 46-49 interleukin 6 Homo sapiens 153-157 23952046-3 2014 Cranberry proanthocyanidins (PACs) inhibit IL-1beta-stimulated IL-6 production, but specific mechanisms are unclear. Proanthocyanidins 10-27 interleukin 6 Homo sapiens 63-67 23952046-3 2014 Cranberry proanthocyanidins (PACs) inhibit IL-1beta-stimulated IL-6 production, but specific mechanisms are unclear. Proanthocyanidins 29-33 interleukin 6 Homo sapiens 63-67 24909288-8 2014 Over-expression of miR-155 significantly reversed the down-regulation of TNF-alpha and IL-6 by TPT in monocytes. triptolide 95-98 interleukin 6 Homo sapiens 87-91 23512917-10 2013 Serum concentrations of resistin and IL6 increased slightly in placebo and decreased slightly with PGX . PolyGlycoplex 99-102 interleukin 6 Homo sapiens 37-40 23578198-2 2013 Our present study revealed that sunitinib-treated RCC cells exhibit senescence characteristics including increased SA-beta-gal activity, DcR2 and Dec1 expression, and senescence-associated secretary phenotype (SASP) such as proinflammatory cytokines interleukin (IL)-1alpha, IL-6 and IL-8 secretion. Sunitinib 32-41 interleukin 6 Homo sapiens 275-279 25177524-7 2014 Biliverdin (50 muM) significantly decreased the LPS-mediated gene expression of IL-1beta, IL-6, IFN-gamma, IL-1Ra and IL-8 (P<0.05). Biliverdine 0-10 interleukin 6 Homo sapiens 90-94 29031393-9 2017 An analysis of possible relationships between DHA and the concentrations of different cytokines revealed negative correlation between maternal plasmatic IL-6 and DHA (higher plasmatic DHA corresponded to lower IL-6). Docosahexaenoic Acids 162-165 interleukin 6 Homo sapiens 153-157 29031393-9 2017 An analysis of possible relationships between DHA and the concentrations of different cytokines revealed negative correlation between maternal plasmatic IL-6 and DHA (higher plasmatic DHA corresponded to lower IL-6). Docosahexaenoic Acids 162-165 interleukin 6 Homo sapiens 210-214 24303127-5 2013 Tulobuterol reduced the RV14 titers and RNA levels; the concentrations of cytokines, including interleukin (IL)-1beta, IL-6, and IL-8, in the supernatants; and susceptibility to RV14 infection. tulobuterol 0-11 interleukin 6 Homo sapiens 119-123 29031393-9 2017 An analysis of possible relationships between DHA and the concentrations of different cytokines revealed negative correlation between maternal plasmatic IL-6 and DHA (higher plasmatic DHA corresponded to lower IL-6). Docosahexaenoic Acids 162-165 interleukin 6 Homo sapiens 153-157 29031393-9 2017 An analysis of possible relationships between DHA and the concentrations of different cytokines revealed negative correlation between maternal plasmatic IL-6 and DHA (higher plasmatic DHA corresponded to lower IL-6). Docosahexaenoic Acids 162-165 interleukin 6 Homo sapiens 210-214 24730521-9 2014 DCs stimulated with rIL-37 showed a decreased expression of IL-6, IL-1beta and TNF-alpha, and a higher production of IL-27. ril-37 20-26 interleukin 6 Homo sapiens 60-64 28701056-7 2017 Treatment of IL-1beta stimulated fibroblasts in combination with PHMG-P or CHX at concentrations of 0.000045 or 0.0.00009% resulted in significantly decreased PGE2, IL-6, IL-8 and MMP-1 levels. polyhexamethyleneguanidine 65-71 interleukin 6 Homo sapiens 165-169 25098998-6 2014 For IL-6 (-597) frequency of genotype GA/AA (P = 0.04) and allele A (P = 0.01) was lower in CHPDM group, and for TNF-alpha -308 the frequency of genotype GA (P = 0.01) and allele A (P = 0.01) was higher in CHP subjects when compared with controls. chpdm 92-97 interleukin 6 Homo sapiens 4-8 23583258-3 2013 This report concerns the marked up-regulation in differentiated CaCo-2 colonic epithelial cells of two key inflammatory interleukins, IL-6 and IL-8, caused by a mixture of oxysterols representative of a high cholesterol diet. Oxysterols 172-182 interleukin 6 Homo sapiens 134-138 23511701-0 2013 Concomitant increase in muscle strength and bone mineral density with decreasing IL-6 levels after combination therapy with alendronate and calcitriol in postmenopausal women. Alendronate 124-135 interleukin 6 Homo sapiens 81-85 23511701-0 2013 Concomitant increase in muscle strength and bone mineral density with decreasing IL-6 levels after combination therapy with alendronate and calcitriol in postmenopausal women. Calcitriol 140-150 interleukin 6 Homo sapiens 81-85 28701056-7 2017 Treatment of IL-1beta stimulated fibroblasts in combination with PHMG-P or CHX at concentrations of 0.000045 or 0.0.00009% resulted in significantly decreased PGE2, IL-6, IL-8 and MMP-1 levels. Chlorhexidine 75-78 interleukin 6 Homo sapiens 165-169 28663336-7 2017 PGE2, PGI2, and PGA2 exhibited the most potent barrier-enhancing effects and most efficient attenuation of thrombin-induced EC permeability and contractile response, whereas PGI2 effectively suppressed thrombin-induced permeability but was less efficient in the attenuation of prolonged EC hyperpermeability caused by interleukin-6 or bacterial wall lipopolysaccharide, LPS. prostaglandin A2 16-20 interleukin 6 Homo sapiens 318-331 23629517-6 2013 Analysis shows that CAS induced the release of IL8 and IL6. cas 20-23 interleukin 6 Homo sapiens 55-58 24631089-0 2014 As a genetic adjuvant, CTA improves the immunogenicity of DNA vaccines in an ADP-ribosyltransferase activity- and IL-6-dependent manner. crotonic acid 23-26 interleukin 6 Homo sapiens 114-118 24370115-0 2014 Ultrasensitive IL-6 electrochemical immunosensor based on Au nanoparticles-graphene-silica biointerface. Gold 58-60 interleukin 6 Homo sapiens 15-19 28584977-10 2017 AD treatment significantly reduced the production of serum anti-CII, TNFalpha, IL-1beta, and IL-6. andrographolide 0-2 interleukin 6 Homo sapiens 93-97 24370115-1 2014 An Interleukin-6 (IL-6) electrochemical immunosensor was fabricated based on the Au nanoparticles (AuNP)-graphene-silica sol-gel as immobilization biointerface and AuNP-polydopamine (PDA)@carbon nanotubes (CNT) as the label of HRP-bound antibodies. Gold 81-83 interleukin 6 Homo sapiens 3-16 24370115-1 2014 An Interleukin-6 (IL-6) electrochemical immunosensor was fabricated based on the Au nanoparticles (AuNP)-graphene-silica sol-gel as immobilization biointerface and AuNP-polydopamine (PDA)@carbon nanotubes (CNT) as the label of HRP-bound antibodies. Gold 81-83 interleukin 6 Homo sapiens 18-22 24521260-5 2014 After treatment of normal human epidermal keratinocytes with TCDD or PCBs, IL-6 and IL-8 production were increased. Polychlorinated Biphenyls 69-73 interleukin 6 Homo sapiens 75-79 23521530-6 2013 The expression of matrix metalloproteinases (MMP)-1, MMP-2, IL-1, IL-6, TNF-alpha and type 1 collagen was significantly higher in I-GMSCs than in N-GMSCs. i-gmscs 130-137 interleukin 6 Homo sapiens 66-70 28760413-6 2017 Increased hydrogen sulfide and substance P levels in septic patients were associated with increased levels of inflammatory mediators - procalcitonin, C-reactive protein and interleukin-6. Hydrogen Sulfide 10-26 interleukin 6 Homo sapiens 173-186 23199585-7 2013 CAM and AZM induced a dose-dependent suppression of spontaneous TNF-alpha, sTNFR2, IL-6, IL-8 and CCL18 production (p<0.05). Clarithromycin 0-3 interleukin 6 Homo sapiens 83-87 23199585-7 2013 CAM and AZM induced a dose-dependent suppression of spontaneous TNF-alpha, sTNFR2, IL-6, IL-8 and CCL18 production (p<0.05). Azithromycin 8-11 interleukin 6 Homo sapiens 83-87 23199585-10 2013 CAM also inhibited the LPS-stimulated TNF-alpha, IL-1beta, IL-6 and IL-10 production. Clarithromycin 0-3 interleukin 6 Homo sapiens 59-63 24338998-6 2014 Additionally, phloretin inhibited monocyte secretion of MCP-1, IL-6 and IL-8 responsible for pro-inflammatory activity of thrombin inducing endothelial CD40. Phloretin 14-23 interleukin 6 Homo sapiens 63-67 28345770-5 2017 The objectives were to determine the effects of 1,25D3 or a non-calcemic analog, 20-hydroxyvitamin D3 -20(OH)D3 or 20D3-on IL-1beta-stimulated IL-6 and IL-8 production, and NF-kappaB and MAPK/AP-1 activation, by human gingival fibroblasts. 20-hydroxyvitamin d3 -20(oh)d3 81-111 interleukin 6 Homo sapiens 143-147 24415766-4 2014 Two classes of IL-6 SOMAmers were isolated from modified DNA libraries containing 40 random positions and either 5-(N-benzylcarboxamide)-2"-deoxyuridine (Bn-dU) or 5-[N-(1-naphthylmethyl)carboxamide]-2"-deoxyuridine (Nap-dU) replacing dT. 5-[n-(1-naphthylmethyl)carboxamide]-2"-deoxyuridine 164-215 interleukin 6 Homo sapiens 15-19 24415767-5 2014 Here, we report the co-crystal structure of a high affinity SOMAmer (Kd = 0.20 nm) modified at the 5-position of deoxyuridine in a complex with IL-6. Deoxyuridine 113-125 interleukin 6 Homo sapiens 144-148 24395296-11 2014 We have observed that some evidence of interactions of the IL-6 polymorphism and have shown statistical significant association with elevated BMI, Lipid profile and total bilurubin in the study subjects. bilurubin 171-180 interleukin 6 Homo sapiens 59-63 24010298-15 2013 When the mercury concentration was over 1.23 mg x L(-1), Zhuhong ointment showed toxicity to HSF. Mercury 9-16 interleukin 6 Homo sapiens 93-96 24010298-16 2013 At 1.23, 0.62, 0.31 mg x L(-1) of mercury concentration, it increased MMP-1 expression by HSF, and at 1.23, 0.62 mg x L(-1), decreased MMP-2 expression. Mercury 34-41 interleukin 6 Homo sapiens 90-93 23698162-3 2013 In summary, dietary fatty acids, in particular saturated fatty acids and the omega-3 and omega-6 polyunsaturated fatty acids, impact the expression of the cytokine genes TNFA and IL-6, and alter TNFalpha and IL-6 production. dietary fatty acids 12-31 interleukin 6 Homo sapiens 179-183 24456369-6 2014 The identified drugs represent a new class of lead compounds with piperidine, benzothiophene, and indole scaffolds to inhibit IL-6 induced homodimerization of GP130. indole 98-104 interleukin 6 Homo sapiens 126-130 28975158-2 2017 We found that PA-MSHA had a strong ability to activate pro-inflammatory cytokines such as IL-1beta, IL-6 and TNF-alpha. pa-msha 14-21 interleukin 6 Homo sapiens 100-104 24117378-4 2014 We demonstrated that girolline inhibits signaling through both MyD88-dependent and -independent TLRs (i.e., TLR2, 3, 4, 5, and 7) and reduces cytokine (IL-6 and IL-8) production in human peripheral blood mononuclear cells and macrophages. girolline 21-30 interleukin 6 Homo sapiens 152-156 23698162-3 2013 In summary, dietary fatty acids, in particular saturated fatty acids and the omega-3 and omega-6 polyunsaturated fatty acids, impact the expression of the cytokine genes TNFA and IL-6, and alter TNFalpha and IL-6 production. dietary fatty acids 12-31 interleukin 6 Homo sapiens 208-212 23592365-0 2013 Synthesis of epoxyisoprostanes: effects in reducing secretion of pro-inflammatory cytokines IL-6 and IL-12. epoxyisoprostanes 13-30 interleukin 6 Homo sapiens 92-96 28738524-10 2017 miR-125b overexpression statistically increased the expression of TNF-alpha, IL-6, IL-1beta and p-p65 (P<0.05 or P<0.01), but markedly decreased IkappaB-alpha (P<0.05). mir-125b 0-8 interleukin 6 Homo sapiens 77-81 23562757-7 2013 These results demonstrate that AEE and 2Ph affect the stimulation of DCs and their ability to stimulate allogeneic CD4(+) T cells by reducing the production of IFN-gamma, IL-12 p40, IL-6 and IL-23. aspirin eugenol ester 31-34 interleukin 6 Homo sapiens 182-186 23086036-3 2013 Acute IL-6 exposure increased glycogen synthesis, glucose uptake, and signal transducer and activator of transcription 3 (STAT3) phosphorylation in cultured myotubes from normal glucose tolerant subjects. Glycogen 30-38 interleukin 6 Homo sapiens 6-10 24296301-9 2014 Antioxidant treatments (deferoxamine mesylate, (+-)alpha-tocopherol, or tempol) suppressed BDE-47-stimulated IL-6 release by 54.1%, 56.3% and 37.7%, respectively, implicating a role for ROS in the regulation of inflammatory pathways in HTR-8/SVneo cells. tempol 72-78 interleukin 6 Homo sapiens 109-113 23944957-14 2014 Furthermore, miR-221 regulates the hyperproliferation and IL-6 release of ASMCs from patients with severe asthma, but does not regulate corticosteroid insensitivity. asmcs 74-79 interleukin 6 Homo sapiens 58-62 28738247-7 2017 In vivo, asiatic acid significantly inhibited LPS-induced IL-6 and IL-8 expression levels in gingival tissues. asiatic acid 9-21 interleukin 6 Homo sapiens 58-62 24998588-11 2014 The results showed that interleukin-6 (IL-6)-induced JAK/STAT3 activation in KKU-M156 cells was suppressed by treatment with luteolin. Luteolin 125-133 interleukin 6 Homo sapiens 24-37 24998588-11 2014 The results showed that interleukin-6 (IL-6)-induced JAK/STAT3 activation in KKU-M156 cells was suppressed by treatment with luteolin. Luteolin 125-133 interleukin 6 Homo sapiens 39-43 23336518-3 2013 The results showed that chlorogenic acid, 3, 4-dicaffeoylquinic acid, 3, 5-dicaffeoylquinic acid and 4, 5-dicaffeoylquinic acid significantly inhibited the prostaglandin E(2) (PGE(2)) release and reversed the interleukin-6 (IL-6) secretion of macrophages (p < 0.05). 3,4-di-O-caffeoylquinic acid 42-68 interleukin 6 Homo sapiens 209-222 28738247-8 2017 In vitro, LPS-induced PGE2, NO, IL-6, and IL-8 production was significantly attenuated by asiatic acid. asiatic acid 90-102 interleukin 6 Homo sapiens 32-36 23336518-3 2013 The results showed that chlorogenic acid, 3, 4-dicaffeoylquinic acid, 3, 5-dicaffeoylquinic acid and 4, 5-dicaffeoylquinic acid significantly inhibited the prostaglandin E(2) (PGE(2)) release and reversed the interleukin-6 (IL-6) secretion of macrophages (p < 0.05). 3,4-di-O-caffeoylquinic acid 42-68 interleukin 6 Homo sapiens 224-228 23336518-3 2013 The results showed that chlorogenic acid, 3, 4-dicaffeoylquinic acid, 3, 5-dicaffeoylquinic acid and 4, 5-dicaffeoylquinic acid significantly inhibited the prostaglandin E(2) (PGE(2)) release and reversed the interleukin-6 (IL-6) secretion of macrophages (p < 0.05). 4,5-dicaffeoyl quinic acid 101-127 interleukin 6 Homo sapiens 209-222 28738247-11 2017 Furthermore, GW9662, a PPAR-gamma inhibitor, attenuated the inhibitory effect of asiatic acid on PGE2, NO, IL-6, and IL-8 production. asiatic acid 81-93 interleukin 6 Homo sapiens 107-111 23336518-3 2013 The results showed that chlorogenic acid, 3, 4-dicaffeoylquinic acid, 3, 5-dicaffeoylquinic acid and 4, 5-dicaffeoylquinic acid significantly inhibited the prostaglandin E(2) (PGE(2)) release and reversed the interleukin-6 (IL-6) secretion of macrophages (p < 0.05). 4,5-dicaffeoyl quinic acid 101-127 interleukin 6 Homo sapiens 224-228 24500009-0 2014 A citrus flavonoid, 6-demethoxytangeretin, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase and mitogen-activated protein kinase pathways. 6-demethoxytangeretin 20-41 interleukin 6 Homo sapiens 88-101 24500009-6 2014 6-Demethoxytangeretin suppresses interleukin-6 production, tumor necrosis factor-alpha gene expression, ALK and MAPKs in HMC-1 cells stimulated by PMA plus A23187. 6-demethoxytangeretin 0-21 interleukin 6 Homo sapiens 33-46 28532672-1 2017 In this study, we found that catechins found in green tea (EGCG, EGC, and EC) differentially interfere with the IL-1beta signaling pathway which regulates the expression of pro-inflammatory mediators (IL-6 and IL-8) and Cox-2 in primary human rheumatoid arthritis synovial fibroblasts (RASFs). gallocatechol 59-62 interleukin 6 Homo sapiens 201-205 25159306-8 2014 RESULTS: The yields of DHT from 14C-testosterone showed 2-fold and 1.8-fold- inhibition in response to IL-6 and CRP respectively and 28% stimulation in response to Dox, via the 5-alpha reductase pathway. Dihydrotestosterone 23-26 interleukin 6 Homo sapiens 103-107 25159306-9 2014 The combination of IL-6 + CRP showed a 2-fold reduction in the yields of DHT, elevated to control values when combined with Dox (n=8; p<0.001). Dihydrotestosterone 73-76 interleukin 6 Homo sapiens 19-23 25159306-11 2014 CONCLUSIONS: Inhibition of DHT synthesis in osteoblasts by IL-6 and CRP was overcome by doxycycline. Dihydrotestosterone 27-30 interleukin 6 Homo sapiens 59-63 23037942-7 2013 Importantly, contraction-dependent IL-6 up-regulation was markedly suppressed in the presence of high levels of glucose along with increased glycogen accumulations. Glycogen 141-149 interleukin 6 Homo sapiens 35-39 23037942-8 2013 Experimental manipulation of intracellular glycogen contents by modulating available glucose or pyruvate during a certain EPS period further established the suppressive effect of glycogen accumulations on contraction-induced IL-6 up-regulation, which appeared to be independent of calcineurin activity. Glycogen 43-51 interleukin 6 Homo sapiens 225-229 23037942-8 2013 Experimental manipulation of intracellular glycogen contents by modulating available glucose or pyruvate during a certain EPS period further established the suppressive effect of glycogen accumulations on contraction-induced IL-6 up-regulation, which appeared to be independent of calcineurin activity. Glycogen 179-187 interleukin 6 Homo sapiens 225-229 22951300-4 2012 Treatment with rDDT increased levels of phosphorylated ERK1/2, but not p38, in SGBS cells, and rDDT-induced IL-6 mRNA expression was attenuated by pretreatment with an ERK inhibitor, U0126. U 0126 183-188 interleukin 6 Homo sapiens 108-112 25159306-12 2014 Oxidative actions of IL-6 and CRP; and antioxidant actions of Dox are reinforced by the metabolic yields of DHT in response to agents tested. Dihydrotestosterone 108-111 interleukin 6 Homo sapiens 21-25 28532672-1 2017 In this study, we found that catechins found in green tea (EGCG, EGC, and EC) differentially interfere with the IL-1beta signaling pathway which regulates the expression of pro-inflammatory mediators (IL-6 and IL-8) and Cox-2 in primary human rheumatoid arthritis synovial fibroblasts (RASFs). ec 74-76 interleukin 6 Homo sapiens 201-205 28532672-2 2017 EGCG and EGC inhibited IL-6, IL-8, and MMP-2 production and selectively inhibited Cox-2 expression. gallocatechol 0-3 interleukin 6 Homo sapiens 23-27 25144177-10 2014 Initial findings suggest paralyzed skeletal muscle releases IL-6 in response to FES-evoked contractions. fes 80-83 interleukin 6 Homo sapiens 60-64 28656263-8 2017 In addition, Y-27632 and 3-AB diminished extracellular signal-related kinase (ERK) phosphorylation and the production of tumor necrosis factor alpha and interleukin 6. Y 27632 13-20 interleukin 6 Homo sapiens 153-166 22632542-5 2012 RESULTS: Colchicine significantly modulated monosodium urate-induced IL-1beta release, LPS-stimulated LDH release, and basal transcript levels of TNF-alpha and IL-6 in healthy controls and BD colchicine responders, but not in BD colchicine nonresponders. Colchicine 9-19 interleukin 6 Homo sapiens 160-164 29050266-6 2017 The IL-6-stimulated activation of STAT3 and its downstream genes Cyclin D1, survivin, and Bcl-xL was also repressed by Physapubescin B. physapubescin B 119-134 interleukin 6 Homo sapiens 4-8 22381051-9 2012 The level of IL-6 at the end of surgery was lower for sevoflurane (69.5 [35.9-121.0] pg/mL) than propofol-remifentanil (128.2 [92.8-163.8] pg/mL, p = 0.03), but this difference was not maintained 24 hours after surgery. Remifentanil 106-118 interleukin 6 Homo sapiens 13-17 21986708-11 2012 Additionally, rSAA stimulated the secretion of proinflammatory cytokines interleukin 6 and tumor necrosis factor alpha, and upregulated SAA3 mRNA expression during adipogenesis. rsaa 14-18 interleukin 6 Homo sapiens 73-118 25026798-8 2014 Quantitative analysis of urinary IL-6, IL-8, and VEGF levels in patients with SDS may be used to evaluate tubulointerstitial inflammation and to predict the development of interstitial fibrosis. sds 78-81 interleukin 6 Homo sapiens 33-37 23763486-4 2013 This was confirmed in cell culture systems - acrolein stimulated the production of IL-6 in mouse neuroblastoma Neuro-2a cells, mouse macrophage-like J774.1 cells, and human umbilical vein endothelial cells (HUVEC), and IL-6 in turn stimulated the production of CRP in human hepatocarcinoma cells. Acrolein 45-53 interleukin 6 Homo sapiens 219-223 28511912-8 2017 The KDM4A inhibitor ML324 showed similar actions on IL-6 production and colitis induction. ML324 20-25 interleukin 6 Homo sapiens 52-56 23988651-9 2013 In contrast, in aged DCs, LiCl reduced the secretion of TNF-alpha and IL-6 in LPS stimulated DCs but did not increase IL-10. Lithium Chloride 26-30 interleukin 6 Homo sapiens 70-74 22964618-2 2012 This enzyme deficiency results in an accumulation of sphingolipids in the cells of GD patients, which may contribute to the dysregulation of the immune system, B-cell dysfunction and expression of specific cytokines such as interleukin (IL) -1, IL-6, IL-8, IL-10, and tumor necrosis factor (TNF). Sphingolipids 53-66 interleukin 6 Homo sapiens 245-249 28454101-4 2017 In the present study, we found insoluble beta-glucan from the cell wall of Candida albicans (CaIG) was able to increase the production of of IL-6 and TNFalpha through Dectin-1-Syk-NF-kappaB and p38MAPK pathway. beta-Glucans 41-52 interleukin 6 Homo sapiens 141-145 21829163-11 2012 IL-6 concentrations were significantly and directly related to dihomo-gamma-linolenic acid (DGLA) in normal weight (P=0.01) and obese participants (P<0.001), but the scale of increase across tertiles was greater in obese adults. 8,11,14-Eicosatrienoic Acid 63-90 interleukin 6 Homo sapiens 0-4 21829163-11 2012 IL-6 concentrations were significantly and directly related to dihomo-gamma-linolenic acid (DGLA) in normal weight (P=0.01) and obese participants (P<0.001), but the scale of increase across tertiles was greater in obese adults. 8,11,14-Eicosatrienoic Acid 92-96 interleukin 6 Homo sapiens 0-4 24143215-5 2013 Herein we report that miR-329 plays a pivotal role in mediating PDG-induced trophoblast apoptosis and inhibition of IL-6 mRNA expression by targeting the NF-kappaB subunit, p65. mir-329 22-29 interleukin 6 Homo sapiens 116-120 29062346-12 2017 CONCLUSION: Low-dose ketamine attenuated early serum IL-6 levels due to surgical response with reduced 24 hour increase, but the difference was not statistically significant and we recommend more studies. Ketamine 21-29 interleukin 6 Homo sapiens 53-57 22709487-5 2012 In peptidoglycan/polysaccharide-induced polyarthritis, proteasome inhibitors limit the overall inflammation, reduce NF-kappaB activation, decrease cellular adhesion molecule expression, inhibit nitric oxide synthase, attenuate circulating levels of proinflammatory cytokine interleukin-6 and reduce the arthritis index and swelling in the joints of the animals. Polysaccharides 17-31 interleukin 6 Homo sapiens 274-287 28337636-3 2017 Our results showed that EVO effectively suppressed both protein and mRNA expression of interleukin-1beta, interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in vitro. evodiamine 24-27 interleukin 6 Homo sapiens 106-119 22421411-8 2012 IL-6 slightly enhanced the sensitivity of RPMI-8226 cells to erufosine, thus emphasizing the heterogeneity of MM. rpmi 42-46 interleukin 6 Homo sapiens 0-4 23662915-7 2013 RESULTS: Rebamipide could suppress polyI:C-induced cytokine production and the expression of mRNAs for CXCL10, CXCL11, RANTES, MCP-1, and IL-6 in human conjunctival epithelial cells. rebamipide 9-19 interleukin 6 Homo sapiens 138-142 23890848-4 2013 RESULTS: A combination of EPA and DHA significantly reduced the concentration of IL-8 and IL-6 released into the supernatant compared to untreated controls (p<0.001). Dihydroalprenolol 34-37 interleukin 6 Homo sapiens 90-94 22559798-5 2012 Clarithromycin treatment decreased the levels of eosinophilic cationic protein only in non-allergic patients (p < 0.05), and decreased the level of interleukin 6 only in allergic patients (p < 0.05). Clarithromycin 0-14 interleukin 6 Homo sapiens 151-164 28337636-3 2017 Our results showed that EVO effectively suppressed both protein and mRNA expression of interleukin-1beta, interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in vitro. evodiamine 24-27 interleukin 6 Homo sapiens 121-125 28337636-5 2017 In vivo, treatment with EVO markedly decreased TNF-alpha and IL-6 levels in plasma. evodiamine 24-27 interleukin 6 Homo sapiens 61-65 28257794-3 2017 Hinokitiol treatment inhibited LPS-mediated up-regulation of proinflammatory factors including tumor necrosis factor alpha, IL-6, and prostaglandin E2 (PGE2). beta-thujaplicin 0-10 interleukin 6 Homo sapiens 124-128 22387385-6 2012 Moreover, vitamin D3 significantly reduced the levels of proinflammatory cytokines (TNF-alpha, IL-6, IL-12p70 and IL-1beta) produced by infected U937 cells. Cholecalciferol 10-20 interleukin 6 Homo sapiens 95-99 23299767-1 2013 PURPOSE: The objective of this study is as follows: 1) to determine the effects of caffeine supplementation on the inflammatory response (IL-6 and IL-10 levels and leukocyte numbers) induced by a 15-km run competition and 2) to examine the effect of caffeine supplementation on the energetic metabolites as well as on the exercise-induced oxidative stress. Caffeine 83-91 interleukin 6 Homo sapiens 138-142 23299767-12 2013 CONCLUSION: Caffeine supplementation induced higher levels of IL-6 and IL-10 in response to exercise, enhancing the anti-inflammatory response. Caffeine 12-20 interleukin 6 Homo sapiens 62-66 23299767-13 2013 The caffeine-induced increase in adrenaline could be responsible for the higher increase in IL-6 levels, as well as for the increased lactate levels. Caffeine 4-12 interleukin 6 Homo sapiens 92-96 23826152-7 2013 Additionally, OXA caused concentration-dependent P2X7 receptor activation, increased chromatin condensation and caspase-3 activation associated with TNF-alpha and IL-6 release. Oxaliplatin 14-17 interleukin 6 Homo sapiens 163-167 22454545-5 2012 Cells exposed to PBDEs released significantly less pro-inflammatory cytokines (TNF-alpha and IL-6) and PGE(2) compared with controls; IL-1beta and IL-10 were not detected in the culture medium. Halogenated Diphenyl Ethers 17-22 interleukin 6 Homo sapiens 93-97 28106314-10 2017 CONCLUSION: Patients who were treated with clozapine for the first time have an increased rate of developing a fever, and IL-6 might have a specific role in the interaction effect between treatment duration and fever development. Clozapine 43-52 interleukin 6 Homo sapiens 122-126 22385289-10 2012 In the GO group, significant positive correlation was found between CAS and the release of IL-6 and PAI-1 into tears (r=0.27, p<0.05 and r=0.24, p<0.05, respectively). cas 68-71 interleukin 6 Homo sapiens 91-95 23161900-11 2013 Finally, DAPT significantly decreased VEGF/Ang2 induced IL-6, IL-8, MMP2 and 9 expressions in RA synovial explants. dapt 9-13 interleukin 6 Homo sapiens 56-60 28492559-8 2017 The combination of bufalin with MK2206 reduced the secretion of IL-6 in U266 cells. MK 2206 32-38 interleukin 6 Homo sapiens 64-68 23698162-3 2013 In summary, dietary fatty acids, in particular saturated fatty acids and the omega-3 and omega-6 polyunsaturated fatty acids, impact the expression of the cytokine genes TNFA and IL-6, and alter TNFalpha and IL-6 production. omega-6 polyunsaturated fatty acids 89-124 interleukin 6 Homo sapiens 179-183 23698162-3 2013 In summary, dietary fatty acids, in particular saturated fatty acids and the omega-3 and omega-6 polyunsaturated fatty acids, impact the expression of the cytokine genes TNFA and IL-6, and alter TNFalpha and IL-6 production. omega-6 polyunsaturated fatty acids 89-124 interleukin 6 Homo sapiens 208-212 23698162-5 2013 When interactions between dietary fatty acids and TNFA and IL-6 SNPs on obesity and serum lipid were analyzed, both the quantity and quality of dietary fatty acids modulated the relationship between TNFA and IL-6 SNPs on obesity and serum lipid profiles, thereby impacting the association between phenotype and genotype. dietary fatty acids 144-163 interleukin 6 Homo sapiens 59-63 23698162-5 2013 When interactions between dietary fatty acids and TNFA and IL-6 SNPs on obesity and serum lipid were analyzed, both the quantity and quality of dietary fatty acids modulated the relationship between TNFA and IL-6 SNPs on obesity and serum lipid profiles, thereby impacting the association between phenotype and genotype. dietary fatty acids 144-163 interleukin 6 Homo sapiens 208-212 22169009-8 2012 Immunohistochemistry showed that calcitriol and paricalcitol reduced MCP-1 and IL-6 in podocytes and tubular cells as well as glomerular infiltration by macrophages, glomerular cell NF-kappaB activation, apoptosis, and extracellular matrix deposition. Calcitriol 33-43 interleukin 6 Homo sapiens 79-83 22169009-9 2012 In cultured podocytes, paricalcitol and calcitriol at concentrations in the physiological and clinically significant range prevented the increase in MCP-1, IL-6, renin, and fibronectin mRNA expression and the secretion of MCP-1 to the culture media induced by high glucose. Calcitriol 40-50 interleukin 6 Homo sapiens 156-160 28589165-9 2017 RESULTS: In both murine and human astrocytes, DMF, but not MMF, significantly reduced secretion of IL-6, CXCL10, and CCL2; neither fumarate promoted a robust increase in antioxidant gene expression, although both MMF and DMF prevented intracellular ROS production. Dimethyl Fumarate 46-49 interleukin 6 Homo sapiens 99-103 22868800-6 2012 MDA/TBARS positively correlated with IL-6 and SOD-1 and negatively with catalase. Thiobarbituric Acid Reactive Substances 4-9 interleukin 6 Homo sapiens 37-41 22868800-7 2012 IL-6 and SOD-1 explained 24% in MDA/TBARS variability. Thiobarbituric Acid Reactive Substances 36-41 interleukin 6 Homo sapiens 0-4 23666007-8 2013 Furthermore, veratric acid had inhibitory effects on the UVB-induced release of the inflammatory mediators such as IL-6 and prostaglandin-E2. veratric acid 13-26 interleukin 6 Homo sapiens 115-119 28072760-5 2017 RESULTS: Whether added 2 h pre-, simultaneously to, or 2 h post-TLR stimulation, PTX inhibited TLR-mediated cytokine production in a concentration-dependent manner, with greater efficacy and potency in newborn blood, decreasing intracellular TNF and IL-1beta with relative preservation of IL-10 and IL-6. Pentoxifylline 81-84 interleukin 6 Homo sapiens 299-303 23186593-5 2013 The levels of IL-6, IL-8 and ICAM were significantly lower in the GL group. gl 66-68 interleukin 6 Homo sapiens 14-18 21726210-6 2012 KEY RESULTS: Azithromycin (1.5-50 microM) dose-dependently inhibited gene expression and/or release of M1 macrophage markers (CCR7, CXCL 11 and IL-12p70), but enhanced CCL2, without altering TNF-alpha or IL-6. Azithromycin 13-25 interleukin 6 Homo sapiens 204-208 23562757-6 2013 In contrast, as compared with control, the secretion of IL-12p40, IL-23 and IL-6 was lower from AEE-DCs and 2Ph-CDs and allogeneic CD4(+) T cells co-cultured with these DCs secreted lower levels of IFN-gamma and IL-10 but the same levels of IL-17. aspirin eugenol ester 96-99 interleukin 6 Homo sapiens 76-80 28188160-10 2017 H2S inhibited the expression of CAPs, NF-kappaB activation and the production of interleukin (IL)-1beta, IL-6 and tumor necrosis factor alpha (TNFalpha) in cultured USMCs. Hydrogen Sulfide 0-3 interleukin 6 Homo sapiens 105-109 23083515-2 2013 The present study aimed to discover the effects of 1a,25-dihydroxyvitamin D3 (1,25D) on the expressions of interleukin (IL)-6 and IL-8 in human periodontal ligament cells (hPDLCs) stimulated with Porphyromonas gingivalis (P. gingivalis) W83. Calcitriol 51-76 interleukin 6 Homo sapiens 107-125 21161531-6 2012 Furthermore, IL-6 and IL-8 expression was quantified by real-time polymerase chain reaction (RT-PCR) and ELISAs from cells which were exposed to SB203580, U0126 and NaHS and stimulated by IL-1beta. U 0126 155-160 interleukin 6 Homo sapiens 13-17 22003087-9 2012 TGF-beta(1) upregulated release of IL-6 into the supernatant of ASMC from all subjects. asmc 64-68 interleukin 6 Homo sapiens 35-39 28218703-5 2017 The anti-inflammatory (tumor necrosis factor-alpha [TNF-alpha] and interleukin-6 [IL-6]) activities of the polyphenol fractions of the blueberries were investigated by using lipopolysaccharide (LPS) induced RAW 264.7 macrophages. Polyphenols 107-117 interleukin 6 Homo sapiens 67-80 22085605-9 2012 IL-6 levels were directly correlated with di-Tyr and inversely correlated with GPx activity. dityrosine 42-48 interleukin 6 Homo sapiens 0-4 23480345-7 2013 In particular, remifentanil decreased activation of intracellular signaling pathways, including p38 and ERK1/2, and expression of pro-inflammatory cytokines, including TNF-alpha, IL-6 and IL-8. Remifentanil 15-27 interleukin 6 Homo sapiens 179-183 28218703-5 2017 The anti-inflammatory (tumor necrosis factor-alpha [TNF-alpha] and interleukin-6 [IL-6]) activities of the polyphenol fractions of the blueberries were investigated by using lipopolysaccharide (LPS) induced RAW 264.7 macrophages. Polyphenols 107-117 interleukin 6 Homo sapiens 82-86 23268743-5 2013 In the TNF-alpha-induced 3T3-L1 adipocyte model, garcinol and pterostilbene significantly decreased the mRNA expression of COX-2, iNOS, IL-6, and IL-1beta and IL-6 secretion by suppressing phosphorylation of p-IkappaBalpha and p-p65. pterostilbene 62-75 interleukin 6 Homo sapiens 136-140 23268743-5 2013 In the TNF-alpha-induced 3T3-L1 adipocyte model, garcinol and pterostilbene significantly decreased the mRNA expression of COX-2, iNOS, IL-6, and IL-1beta and IL-6 secretion by suppressing phosphorylation of p-IkappaBalpha and p-p65. pterostilbene 62-75 interleukin 6 Homo sapiens 159-163 23268743-6 2013 In a coculture model of 3T3-L1 adipocytes and RAW 264.7 macrophages, pterostilbene suppressed IL-6 and TNF-alpha secretion and proinflammatory mRNA expression and also reduced the migration of macrophages toward adipocytes. pterostilbene 69-82 interleukin 6 Homo sapiens 94-98 23268743-7 2013 In the RAW 264.7 macrophage-derived conditioned medium (RAW-CM)-induced 3T3-L1 adipocyte and 3T3-CM-induced RAW 264.7 macrophage models, pterostilbene significantly decreased IL-6 and TNF-alpha secretion and proinflammatory mRNA expression (COX-2, iNOS, IL-6, TNF-alpha, PAI-1, CRP, MCP-1, resistin, and leptin). pterostilbene 137-150 interleukin 6 Homo sapiens 175-179 23268743-7 2013 In the RAW 264.7 macrophage-derived conditioned medium (RAW-CM)-induced 3T3-L1 adipocyte and 3T3-CM-induced RAW 264.7 macrophage models, pterostilbene significantly decreased IL-6 and TNF-alpha secretion and proinflammatory mRNA expression (COX-2, iNOS, IL-6, TNF-alpha, PAI-1, CRP, MCP-1, resistin, and leptin). pterostilbene 137-150 interleukin 6 Homo sapiens 254-258 22330622-6 2012 CONCLUSION: CAS was associated with a significant increase in plasma CRP, IL-6 and TNF-alpha. cas 12-15 interleukin 6 Homo sapiens 74-78 27776235-6 2017 Furthermore, the results indicated that EGCG inhibited the production of reactive oxygen species (ROS), tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6) in MC-LR-stimulated HUVECs. cyanoginosin LR 173-178 interleukin 6 Homo sapiens 149-162 22339105-11 2012 Findings indicated that effective application of FIR decreased the serum level of IL-6 and ET-1, which represent the subjective indicator of pain. fir 49-52 interleukin 6 Homo sapiens 82-86 23183108-5 2013 In human peripheral blood mononuclear cells, AS1940477 inhibited lipopolysaccharide (LPS)- or phytohemagglutinin A (PHA)-induced production of proinflammatory cytokines, including TNFalpha, IL-1beta, and IL-6 at low concentrations (LPS/TNFalpha, IC(50)=0.45n M; PHA/TNFalpha, IC(50)=0.40 nM). 6-(2-(4-fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo(1,5-a)pyrimidin-3-yl)-2-(2-methylphenyl)pyridazin-3(2H)-one 45-54 interleukin 6 Homo sapiens 204-208 23183108-6 2013 In addition, equivalent concentrations of AS1940477 that inhibited cytokine production also inhibited TNFalpha- and IL-1 beta-induced production of IL-6, PGE(2), and MMP-3 in human synovial stromal cells. 6-(2-(4-fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo(1,5-a)pyrimidin-3-yl)-2-(2-methylphenyl)pyridazin-3(2H)-one 42-51 interleukin 6 Homo sapiens 148-152 27776235-6 2017 Furthermore, the results indicated that EGCG inhibited the production of reactive oxygen species (ROS), tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6) in MC-LR-stimulated HUVECs. cyanoginosin LR 173-178 interleukin 6 Homo sapiens 164-168 24348674-4 2013 MH7A cells were stimulated with IL1 beta and then treated with different concentrations of 1,25(OH)2D3 for 48 h. A significantly elevated OPG/RANKL ratio and markedly decreased levels of IL-6 and TNF beta mRNA expression in cells and IL-6 protein in supernatants were observed in IL1 beta -induced MH7A in the presence of 1,25(OH)2D3 compared with those in the absence of it. Calcitriol 91-102 interleukin 6 Homo sapiens 187-191 24348674-4 2013 MH7A cells were stimulated with IL1 beta and then treated with different concentrations of 1,25(OH)2D3 for 48 h. A significantly elevated OPG/RANKL ratio and markedly decreased levels of IL-6 and TNF beta mRNA expression in cells and IL-6 protein in supernatants were observed in IL1 beta -induced MH7A in the presence of 1,25(OH)2D3 compared with those in the absence of it. Calcitriol 91-102 interleukin 6 Homo sapiens 234-238 22131344-7 2012 Azithromycin, added 2 h before activation of iDCs with LPS, enhanced IL-10 release and inhibited IL-6, IL-12p40, CXCL10, CXCL11, and CCL22 release. Azithromycin 0-12 interleukin 6 Homo sapiens 97-101 27913418-6 2017 Subsequently, we demonstrated that DG-EPS displays immunostimulating properties by enhancing the gene expression of the proinflammatory cytokines tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6), and particularly that of the chemokines IL-8 and CCL20, in the human monocytic cell line THP-1. dg-eps 35-41 interleukin 6 Homo sapiens 190-203 22190977-4 2012 Blockage of Notch signaling by a gamma-secretase inhibitor (DAPT) inhibited IL-6 secretion of RA FLSs in response to TNF-alpha while treatment with recombinant fusion protein of Notch ligand Delta-like 1 promoted such response. dapt 60-64 interleukin 6 Homo sapiens 76-80 21972215-9 2012 The expressions of p-FAK, p-RhoA, p-Rac/Cdc42, MMP2, and alpha5beta3 integrin induced by PU-Au 43.5 ppm were more pronounced in BAEC versus HSF. pu-au 89-94 interleukin 6 Homo sapiens 140-143 22610152-3 2013 Monocyte-expressed heat shock protein 72 (HSP72) and plasma thiobarbituric acid reactive substances (TBARS) were significantly attenuated in BICARB compared to PLAC (p = 0.04 and p = 0.039, respectively), however total anti-oxidant capacity, the ratio of oxidised to total glutathione, cortisol, interleukin 6 and interleukin 8 were not significantly induced by the exercise. Sodium Bicarbonate 141-147 interleukin 6 Homo sapiens 296-309 27913418-6 2017 Subsequently, we demonstrated that DG-EPS displays immunostimulating properties by enhancing the gene expression of the proinflammatory cytokines tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6), and particularly that of the chemokines IL-8 and CCL20, in the human monocytic cell line THP-1. dg-eps 35-41 interleukin 6 Homo sapiens 205-209 27818020-9 2017 Levels of soluble IL-6 in HUVEC supernatants were significantly lower after pre-incubation with ezetimibe. Ezetimibe 96-105 interleukin 6 Homo sapiens 18-22 23054013-3 2013 The polysaccharide obtained from these bacteria induces the expression of interleukin (IL)-1 beta, tumor necrosis factor, and IL-6. Polysaccharides 4-18 interleukin 6 Homo sapiens 126-130 21881585-0 2012 Dihydrotestosterone-inducible IL-6 inhibits elongation of human hair shafts by suppressing matrix cell proliferation and promotes regression of hair follicles in mice. Dihydrotestosterone 0-19 interleukin 6 Homo sapiens 30-34 21881585-3 2012 IL-6 was upregulated 3 hours after 10-100 nM DHT treatment, and ELISA showed that IL-6 was secreted from balding DP cells in response to DHT. Dihydrotestosterone 47-50 interleukin 6 Homo sapiens 0-4 21881585-3 2012 IL-6 was upregulated 3 hours after 10-100 nM DHT treatment, and ELISA showed that IL-6 was secreted from balding DP cells in response to DHT. Dihydrotestosterone 139-142 interleukin 6 Homo sapiens 84-88 27974457-9 2017 Although DMF treatment (both in vivo and in vitro) minimally impacted B cell IL-10 expression, it strongly reduced B cell expression of GM-CSF, IL-6, and TNF-alpha, resulting in a significant anti-inflammatory shift of B cell response profiles. Dimethyl Fumarate 9-12 interleukin 6 Homo sapiens 144-148 21881585-7 2012 Taken together, our data strongly suggest that DHT-inducible IL-6 inhibits hair growth as a paracrine mediator from the DP. Dihydrotestosterone 47-50 interleukin 6 Homo sapiens 61-65 22677645-10 2012 We conclude that the sexual dimorphism in adipose tissue behavior in humans extends to adipose tissue sphingolipid content its association with adiponectin, IL-6 and insulin resistance. Sphingolipids 102-114 interleukin 6 Homo sapiens 157-161 23285694-9 2012 GGH, GHK, CuCl2 and their copper complexes decreased TNF-alpha-dependent IL-6 secretion in fibroblasts. cupric chloride 10-15 interleukin 6 Homo sapiens 73-77 27717503-7 2017 This role is impaired in ATB patients manifested by low expression of HLA-DR and low production of IL-6. atb 25-28 interleukin 6 Homo sapiens 99-103 22955917-4 2012 Importantly, FK866 in a dose-dependent fashion triggered cytotoxicity in MM cells resistant to conventional and novel anti-MM therapies and overcomes the protective effects of cytokines (IL-6, IGF-1) and bone marrow stromal cells. N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide 13-18 interleukin 6 Homo sapiens 187-191 22526597-8 2012 The decreased activation of RelA by calcitriol was confirmed by decreased release of RelA-inducible molecules, including IL-5, IL-6 and IL-8, by HBSMCs upon calcitriol treatment. Calcitriol 36-46 interleukin 6 Homo sapiens 127-131 22051322-11 2011 RESULTS: In macrophages and PBL, RHP and GLGPG inhibited NO and PGE(2) production and reduced the secretion of cytokines (TNF-alpha, IFN-gamma, IL-1beta, IL-6, IL-12) and chemokines (CCL5/RANTES, CXCL10/IP-10). glgpg 41-46 interleukin 6 Homo sapiens 154-158 22110192-7 2011 GO-Y78 also 14-fold more potently inhibited IL-6 production. go-y78 0-6 interleukin 6 Homo sapiens 44-48 21757746-8 2011 Using a luciferase reporter, we demonstrated that LPS treatment induced IL6 promoter-driven luciferase which was suppressed using MEK/ERK pharmacologic inhibitors (PD98059 or U0126) and RNAi-induced depletion of N-Ras. U 0126 175-180 interleukin 6 Homo sapiens 72-75 22526597-8 2012 The decreased activation of RelA by calcitriol was confirmed by decreased release of RelA-inducible molecules, including IL-5, IL-6 and IL-8, by HBSMCs upon calcitriol treatment. Calcitriol 157-167 interleukin 6 Homo sapiens 127-131 27569681-10 2017 IL-6 correlated inversely with VA in young (r=-0.376; P=0.022) but not older adults (p>0.05), while IL-8 correlated with VA in older but not young adults (r>=0.378, P<=0.027). Vanillic Acid 31-33 interleukin 6 Homo sapiens 0-4 22580716-9 2012 As compared with endotoxin-negative TAs, endotoxin-positive TAs demonstrated significantly greater tumor necrosis factor (TNF), interleukin (IL)-6, IL-10, and serpin peptidase inhibitor, clade E, member 1 (SERPINE1) mRNA, and IL-10, TNF, and IL-1beta protein. tas 60-63 interleukin 6 Homo sapiens 128-146 23060925-9 2012 Treg and IL-6 levels decreased following GEM monochemotherapy, IL-17A levels decreased after GEMOX, and IL-6 levels were reduced subsequent to BEV+CAPE+RT treatment. Capecitabine 147-151 interleukin 6 Homo sapiens 104-108 20817712-6 2011 Serum IL-6 and TNF decreased during prednisone therapy in TB-IRIS patients. Prednisone 36-46 interleukin 6 Homo sapiens 6-10 27872213-7 2017 Specifically, type I IFNs promote Ag presentation on MHC I molecules, CD86 and CD40 expression, and the production of IL-12 p70, IL-2, IL-6, and TNF-alpha by beta-glucan-stimulated DCs. beta-Glucans 158-169 interleukin 6 Homo sapiens 135-139 21343371-0 2011 IL6-STAT3-HIF signaling and therapeutic response to the angiogenesis inhibitor sunitinib in ovarian clear cell cancer. Sunitinib 79-88 interleukin 6 Homo sapiens 0-3 22562653-8 2012 Pretreatment with DHT inhibited NF-kappaB activation and suppressed secretion of several inflammatory/growth factors, with the most pronounced effects on IL8, IL6, and bFGF. Dihydrotestosterone 18-21 interleukin 6 Homo sapiens 159-162 21350317-9 2011 Our results showed that calcitriol can effectively suppress iPTH secretion, reduce inflammatory markers (CRP and IL-6) and oxidative stress. Calcitriol 24-34 interleukin 6 Homo sapiens 113-117 29098203-5 2017 Results: The levels of SaFA, including palmitic (16:0) and stearic (18:0) acid were enriched in HIV+ participants (pre- and post-ART), and SaFA levels were often positively correlated with levels of immune activation (ie, IL-6, sCD14, and TNFR1) at baseline and week 48. safa 23-27 interleukin 6 Homo sapiens 222-226 21352574-8 2011 In mucosa and polyp epithelial cells, mometasone inhibited this induced secretion while desloratadine inhibited IL-6 and IL-8. desloratadine 88-101 interleukin 6 Homo sapiens 112-116 21352574-9 2011 The combination of 10(-5) M desloratadine and 10(-9) M mometasone reduced IL-6 secretion (48 +- 11%, p < 0.05) greater extent than mometasone alone (68 +- 10%) compared to control (100%). desloratadine 28-41 interleukin 6 Homo sapiens 74-78 22434859-4 2012 The sodium salt of IQ-1 inhibited LPS-induced TNF-alpha and IL-6 production in MonoMac-6 cells with IC(50) values of 0.25 and 0.61 muM, respectively. sodium salt 4-15 interleukin 6 Homo sapiens 60-64 27539101-5 2016 Many significant associations were found between the increase of IL-6, resp. SAA and the amounts of n-6 polyunsaturated fatty acids (namely linoleic, dihomo-gamma-linolenic, docosatetraenoic and docosapentaenoic acid), resp. saturated fatty acids (pentadecanoic, stearic, nonadecanoic) in erythrocyte membranes. docosapentaenoic acid 195-216 interleukin 6 Homo sapiens 65-69 22547654-8 2012 This suggests that BCDT improved disease progression, at least partly, by eliminating IL-6-producing B cells in MS patients. bcdt 19-23 interleukin 6 Homo sapiens 86-90 21345222-8 2011 OPN301 significantly decreased Pam3CSK4-induced cytokine production of tumour necrosis factor alpha (TNF-alpha), IL-1beta, IL-6, interferon (IFN)-gamma and IL-8 compared to IgG control in RA PBMCs and SFMCs cultures (all P < 0.05). opn301 0-6 interleukin 6 Homo sapiens 123-127 27658890-8 2016 Compared with placebo, myo-inositol intervention significantly reduced IL6 levels in BAL over 6 months (P = 0.03). Inositol 23-35 interleukin 6 Homo sapiens 71-74 21131394-3 2011 An important effect of TGF-beta on ASMC inflammatory responses is the induction of IL-6 release. asmc 35-39 interleukin 6 Homo sapiens 83-87 22319029-5 2012 The effects of overnight incubation with the highly specific NAMPT inhibitor FK866 on the GH-stimulated monocyte chemotactic protein-1 and IL-6 expression in mature SCA were evaluated. N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide 77-82 interleukin 6 Homo sapiens 139-143 27992360-8 2016 CKD serum/homocysteine/CD40L/increased TNF-alpha/IL-6/IFN-gamma-induced CD40/CD40 intermediate monocyte in peripheral blood monocyte. Homocysteine 10-22 interleukin 6 Homo sapiens 49-53 21954917-4 2012 Treatment with the HO-1 inducer CoPP (cobalt protoporphyrin IX) counteracted the stimulatory effects of IL-1beta on IL-6, nitrite, PGE2 (prostaglandin E2), TGF (transforming growth factor) beta2, TGFbeta3 and osteocalcin. cobaltiprotoporphyrin 38-62 interleukin 6 Homo sapiens 116-120 21308460-5 2011 Specific antiretroviral agents (eg, abacavir) have been associated with higher rates of myocardial infarctions and elevations in markers of inflammation such as interleukin-6 and D-dimer in persons with CHD events. abacavir 36-44 interleukin 6 Homo sapiens 161-174 21274876-8 2011 Patients with abnormal PHES had higher CRP (17 +- 22 vs 7 +- 6, P < 0.01), IL6 (32 +- 54 vs 12 +- 13, P < 0.05) and TNFalpha (17 +- 8 vs 11 +- 7, P < 0.001) levels than those with normal PHES. Phenylalanine 23-27 interleukin 6 Homo sapiens 78-81 27713966-0 2016 Hydroxysafflor yellow A inhibits IL-1beta-induced release of IL-6, IL-8, and MMP-1 via suppression of ERK, NF-kappaB and AP-1 signaling in SW982 human synovial cells. hydroxysafflor yellow A 0-23 interleukin 6 Homo sapiens 61-65 20672290-11 2011 The effect of LiCl on IL-6/IL-8/IL-10 secretion in iDC is mediated through inhibition of GSK-3beta. Lithium Chloride 14-18 interleukin 6 Homo sapiens 22-26 21497499-0 2012 Piceatannol inhibits migration and invasion of prostate cancer cells: possible mediation by decreased interleukin-6 signaling. 3,3',4,5'-tetrahydroxystilbene 0-11 interleukin 6 Homo sapiens 102-115 21497499-10 2012 Interleukin-6 treatment was also shown to enhance the secretion of uPA and VEGF, STAT3 phosphorylation and the migration of DU145 cells; these increases were suppressed by piceatannol. 3,3',4,5'-tetrahydroxystilbene 172-183 interleukin 6 Homo sapiens 0-13 21497499-11 2012 These results demonstrate that the inhibition of IL-6/STAT3 signaling may constitute a mechanism by which piceatannol regulates the expression of proteins involved in regulating the migration and invasion of DU145 cells. 3,3',4,5'-tetrahydroxystilbene 106-117 interleukin 6 Homo sapiens 49-53 27713966-7 2016 These results indicate that the inhibitory effects of HSYA on IL-1beta-induced IL-6, IL-8 and MMP-1 release might be mediated via suppression of ERK, nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1) signaling pathways. hydroxysafflor yellow A 54-58 interleukin 6 Homo sapiens 79-83 22324945-11 2012 Mitogen-activated protein kinase (MAPK)/extracellular signal-related kinase (ERK) kinase (MEK)1/2 inhibitor U0126 inhibited the effect of IL-6/sIL-6R on ADAMTS-4 mRNA expression in FLS. U 0126 108-113 interleukin 6 Homo sapiens 138-142 21628878-2 2011 SA significantly inhibited phorbol myristate acetate (PMA) plus A23187-induced the production and expression of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha in human mast cell (HMC)-1 cells. saikosaponin D 0-2 interleukin 6 Homo sapiens 112-130 26968431-2 2016 This was explored by measuring AgNP-stimulated gene expression of the pro-inflammatory cytokines interleukin-1 (IL-1), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) in THP-1 monocytes. agnp 31-35 interleukin 6 Homo sapiens 119-132 22040886-3 2011 We found that a potent androgen, 5alpha-dihydrotestosterone (DHT) inhibits IL-1alpha-induced production and mRNA expression of IL-8, IL-6 and IL-1beta from RA patient-derived fibroblast-like synovial cell line MH7A. Dihydrotestosterone 33-59 interleukin 6 Homo sapiens 133-137 22040886-3 2011 We found that a potent androgen, 5alpha-dihydrotestosterone (DHT) inhibits IL-1alpha-induced production and mRNA expression of IL-8, IL-6 and IL-1beta from RA patient-derived fibroblast-like synovial cell line MH7A. Dihydrotestosterone 61-64 interleukin 6 Homo sapiens 133-137 22993937-3 2012 The treatment with azithromycin, in addition to the high eradication rates, was also evident of its effect on the cytokine levels in the patients, that was characteristic of a significant increase of the IFN-gamma level and a decrease of the IL-1beta and IL-6 levels in the blood. Azithromycin 19-31 interleukin 6 Homo sapiens 255-259 22284780-11 2012 Specifically, apiegenin, baicalein, curcumin, EGCG, genistein, luteolin, oridonin, quercetin, and wogonin repress NF-kappaB (NF-kappaB, a proinflammatory transcription factor) and inhibit proinflammatory cytokines such as TNF-alpha and IL-6. Luteolin 63-71 interleukin 6 Homo sapiens 236-240 26968431-2 2016 This was explored by measuring AgNP-stimulated gene expression of the pro-inflammatory cytokines interleukin-1 (IL-1), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) in THP-1 monocytes. agnp 31-35 interleukin 6 Homo sapiens 134-138 21496413-11 2011 Bosentan significantly reduced IL-2, IL-6, IL-8 and IFN- gamma levels in SSc patients, probably slowing progression to fibrosis and vascular damage. Bosentan 0-8 interleukin 6 Homo sapiens 37-41 26968431-4 2016 The aims of the study were to clearly demonstrate that AgNP can significantly up-regulate pro-inflammatory cytokine gene expression of IL-1, IL-6 and TNF-alpha in both THP-1 cells and primary blood monocytes thus indicating a rapid response to AgNP in circulation. agnp 55-59 interleukin 6 Homo sapiens 141-145 26968431-4 2016 The aims of the study were to clearly demonstrate that AgNP can significantly up-regulate pro-inflammatory cytokine gene expression of IL-1, IL-6 and TNF-alpha in both THP-1 cells and primary blood monocytes thus indicating a rapid response to AgNP in circulation. agnp 244-248 interleukin 6 Homo sapiens 141-145 21050239-0 2010 Vitamin D3 treatment of Crohn"s disease patients increases stimulated T cell IL-6 production and proliferation. Cholecalciferol 0-10 interleukin 6 Homo sapiens 77-81 22761540-3 2012 Clarithromycin (CAM), which is an antimicrobial agent and is also known as an immunomodulator, significantly suppressed RSV-induced production of interleukin-6, interleukin-8, and regulated on activation, normal T-cell expressed and secreted (RANTES). Clarithromycin 0-14 interleukin 6 Homo sapiens 146-159 22761540-3 2012 Clarithromycin (CAM), which is an antimicrobial agent and is also known as an immunomodulator, significantly suppressed RSV-induced production of interleukin-6, interleukin-8, and regulated on activation, normal T-cell expressed and secreted (RANTES). Clarithromycin 16-19 interleukin 6 Homo sapiens 146-159 21050239-6 2010 Vitamin D3 treatment increased interleukin-6 production (delta = 188 pg/mL, range: -444 to 4071) compared with a decrease in the placebo group (delta = -896 pg/mL, range: -3841 to 1323) (P < 0.02, Wilcoxon rank sum test). Cholecalciferol 0-10 interleukin 6 Homo sapiens 31-44 27650973-7 2016 NE-induced IL-6 was significantly inhibited by p38 inhibitor, SB203580, suggesting that NE-induced phosphorylation of p38 via ARbeta enhances IL-6 production in SSc fibroblasts. arbeta 126-132 interleukin 6 Homo sapiens 11-15 21050239-8 2010 CONCLUSIONS: Vitamin D3 treatment of Crohn"s disease patients increased the IL-6 levels. Cholecalciferol 13-23 interleukin 6 Homo sapiens 76-80 20961405-3 2010 Earlier we reported that Dimethylfumarate (DMF) inhibits platelet-derived growth factor (PDGF)-BB induced mitogen and stress activated kinase (MSK)-1 and CREB activity as well as IL-6 secretion by ASMC. asmc 197-201 interleukin 6 Homo sapiens 179-183 27650973-7 2016 NE-induced IL-6 was significantly inhibited by p38 inhibitor, SB203580, suggesting that NE-induced phosphorylation of p38 via ARbeta enhances IL-6 production in SSc fibroblasts. arbeta 126-132 interleukin 6 Homo sapiens 142-146 20379953-0 2010 Kansuinine A and Kansuinine B from Euphorbia kansui L. inhibit IL-6-induced Stat3 activation. kansuinin A 0-12 interleukin 6 Homo sapiens 63-67 20379953-2 2010 We found that two diterpenoids, kansuinine A and B, from E. KANSUI have an inhibitory effect on IL-6-induced Stat3 activation by activating ERK1/2. kansuinin A 32-44 interleukin 6 Homo sapiens 96-100 22029859-8 2011 Tumor necrosis factor-alpha and interleukin-6 release was clearly increased by DC incubated with H-1PV-induced SK29-Mel tumor cell lysates (TCL) and was also high with DC-CTL co-cultures incubated with H-1PV-induced TCL. Triclosan 140-143 interleukin 6 Homo sapiens 32-45 27260851-7 2016 Besides, DHEA inhibited the anchorage-independent growth on agar and decreased the size of spheroids, and also reduced the secretion of IL-1alpha, IL-6, IL-8, and TNF-alpha in all cell lines. Dehydroepiandrosterone 9-13 interleukin 6 Homo sapiens 147-151 21967801-10 2011 Furthermore, by using public datasets that included a total of 684 breast cancer patients, we found that the combined high expression of TG2 and IL-6 was associated with shorter DMFS, compared with the high expression of IL-6 only (P = 0.013). dmfs 178-182 interleukin 6 Homo sapiens 145-149 20379953-3 2010 Inhibition of MEK significantly blocked the effects of kansuinine A and B on IL-6-induced Stat3 activation and tyrosine phosphorylation. kansuinin A 55-67 interleukin 6 Homo sapiens 77-81 20553837-4 2010 Further, AexU prevented phosphorylation of c-Jun, JNK and IkappaBalpha and inhibited IL-6 and IL-8 secretion from HeLa cells. aexu 9-13 interleukin 6 Homo sapiens 85-89 28390203-10 2016 The addition of stannous fluoride suppressed production of TNF-a, IFN-g, IL12p70, IL10, IL-1b, IL2, and IL-6, and also increased secretion of Il-8 in dose response fashion. Tin Fluorides 16-33 interleukin 6 Homo sapiens 104-108 20043171-7 2010 Upregulation of IL-6 and TNF-alpha in immunohistochemistry, and increase in RNA amplification for IL-6 and TNF-alpha were observed after addition of DHT compared with the control. Dihydrotestosterone 149-152 interleukin 6 Homo sapiens 16-20 20043171-7 2010 Upregulation of IL-6 and TNF-alpha in immunohistochemistry, and increase in RNA amplification for IL-6 and TNF-alpha were observed after addition of DHT compared with the control. Dihydrotestosterone 149-152 interleukin 6 Homo sapiens 98-102 21275990-7 2011 Conditioned medium from UCB-challenged neurons, although down-regulating tumor necrosis factor-alpha and interleukin-1beta promoted the release of interleukin-6 and nitric oxide, the activation of matrix metalloproteinase-9, and cell death, as compared with UCB-direct effects on microglia. ucb 24-27 interleukin 6 Homo sapiens 147-160 21276586-5 2011 Simvastatin and fenofibrate decreased monocyte release of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and monocyte chemoattractant protein-1 and lymphocyte release of interleukin-2, interferon-gamma, and tumor necrosis factor-alpha, which was accompanied by a decrease in plasma C-reactive protein levels. Fenofibrate 16-27 interleukin 6 Homo sapiens 106-119 21161336-3 2011 The current study examines whether difluorinated-curcumin (CDF), a novel analog of the dietary ingredient of curcumin, in combination with 5-fluorouracil and oxaliplatin (5-FU + Ox), the mainstay of colon cancer chemotherapeutic, would be effective in eliminating colon CSCs. Oxaliplatin 158-169 interleukin 6 Homo sapiens 59-62 26682953-3 2016 Previously, we and others showed that the effects of DHEA on the skeleton may be conferred partly by their ability to inhibit skeletal catabolic agents, for example, bone resorptive cytokine IL-6. Dehydroepiandrosterone 53-57 interleukin 6 Homo sapiens 191-195 21345194-0 2011 Effects of ulinastatin and docataxel on breast tumor growth and expression of IL-6, IL-8, and TNF-alpha. docataxel 27-36 interleukin 6 Homo sapiens 78-82 20663020-8 2011 RESULTS: Pretreatment of PBMCs with alendronate promoted lipid A-induced production of IL-1beta and IL-6, but decreased lipid A-induced IL-8 and MCP-1 production. Alendronate 36-47 interleukin 6 Homo sapiens 100-104 20421217-8 2010 In addition, MS-275 and SAHA suppressed lipopolysaccharide (LPS)-induced NF-kappaB p65 nuclear accumulation, IL-6, IL-18 and nitric oxide (NO) secretion as well as down-regulated pro-angiogenic VEGF and MMP-2 and MMP-9 production in E11 cells at sub-micromolar levels. entinostat 13-19 interleukin 6 Homo sapiens 109-113 20461739-3 2010 In this study, we investigated the mechanisms by which EGCG, ECG, and TFDG inhibit tumor necrosis factor superfamily 14 (TNFSF14)-induced IL-6 production in HGFs. epicatechin gallate 61-64 interleukin 6 Homo sapiens 138-142 20461739-6 2010 EGCG, ECG, and TFDG prevented TNFSF14-mediated IL-6 production in HGFs. epicatechin gallate 6-9 interleukin 6 Homo sapiens 47-51 20663020-9 2011 In human gingival fibroblasts, alendronate pretreatment increased lipid A-induced production of IL-6 and IL-8, and increased NF-kappaB activation in gingival fibroblasts but not PBMCs stimulated with lipid A. Alendronate 31-42 interleukin 6 Homo sapiens 96-100 26682953-7 2016 This study adds information to indicate that DHEA may be useful for treating bone diseases through its inhibition of skeletal catabolic IL-6 and stimulation of anabolic IGF-I-mediated mechanisms. Dehydroepiandrosterone 45-49 interleukin 6 Homo sapiens 136-140 20663020-11 2011 Finally, SIS3 inhibited alendronate-augmented IL-6 and IL-8 production by human gingival fibroblasts but up-regulated alendronate-decreased IL-8 production by PBMCs. Alendronate 24-35 interleukin 6 Homo sapiens 46-50 27385686-11 2016 Under hypoxic culture conditions, IL-6 gene expression was significantly increased by HIF-1alpha activation using deferoxamine and inhibited by HIF-1alpha inhibition using HIF-1 siRNA. Deferoxamine 114-126 interleukin 6 Homo sapiens 34-38 21426773-1 2011 OBJECTIVE: To evaluate the effect of non-surgical periodontal therapy on periodontal status, glycemic control and the level of serum interleukin (IL)-6 in type 2 diabetic patients with chronic periodontitis (DMCP). Dimyristoylphosphatidylcholine 208-212 interleukin 6 Homo sapiens 133-151 22254128-11 2011 The CBA reproducibility after frozen storage was examined to be most accurate for MCP1 (P = 0.91) > VEGF (P = 0.68) > IL-6 (P = 0.49). cba 4-7 interleukin 6 Homo sapiens 124-128 22371766-4 2010 RESULTS: It was determined that 4-NP significantly up-regulated proinflammatory cytokine expression (toll-like-receptor [TLR]-6, TLR-10, interleukin [IL]-1, IL-5, IL-6, IL-17C, IL-23A, IL-8RB, IL-receptor-associated-kinase [IRAK-2], tumor-necrosis-factor-receptor [TNFR]-5, and TNFR-10). 4-nonylphenol 32-36 interleukin 6 Homo sapiens 163-167 20307528-5 2010 The RT-PCR, real-time PCR, and ELISA analyses demonstrated that LPS-induced mRNAs encoding IL-6 and IL-8 and the subsequent secretion of IL-6 and IL-8 were inhibited by glucosamine treatment. Glucosamine 169-180 interleukin 6 Homo sapiens 91-95 27131739-7 2016 Treating EpCAM+/CD133+ cancer stem cells with IL6 receptor blocking antibody or c-Met inhibitor SU11274 both reduced the increase in motility; however SU11274 had greater effect on relieving protection from sorafenib-induced apoptosis. ((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide) 151-158 interleukin 6 Homo sapiens 46-49 20307528-5 2010 The RT-PCR, real-time PCR, and ELISA analyses demonstrated that LPS-induced mRNAs encoding IL-6 and IL-8 and the subsequent secretion of IL-6 and IL-8 were inhibited by glucosamine treatment. Glucosamine 169-180 interleukin 6 Homo sapiens 137-141 20451499-5 2010 SB202129 and U0126 also significantly attenuated thrombin-mediated release of IL-6 and CXCL8 proteins from HAoSMC. U 0126 13-18 interleukin 6 Homo sapiens 78-82 21430794-1 2011 BACKGROUND: Immune modifications, including changes in interleukin (IL)-6 levels, have often been observed in major depressive disorder (MDD) during treatment with selective serotonin reuptake inhibitors (SSRIs) or the serotonin norepinephrine reuptake inhibitor (SNRI) venlafaxine. Venlafaxine Hydrochloride 270-281 interleukin 6 Homo sapiens 55-73 20337818-12 2010 For PUVA, we observed a significant reduction in TNF-alpha, IL-6 and CRP, and a significant increase in adiponectin. puva 4-8 interleukin 6 Homo sapiens 60-64 27170049-10 2016 Orbital fibroblasts expressed HRH1 and loratadine and SC-514 both blocked histamine-induced IL-6, IL-8 and CCL2 production by orbital fibroblasts. Loratadine 39-49 interleukin 6 Homo sapiens 92-96 20535794-9 2010 IL-6 was significantly higher in patients still requiring prednisone (mean +/- SD 29 +/- 45 versus 13 +/- 17 pg/ml; P = 0.008), and TNFalpha correlated with cumulated prednisone dose (r = 0.292, P = 0.04). Prednisone 58-68 interleukin 6 Homo sapiens 0-4 20535794-9 2010 IL-6 was significantly higher in patients still requiring prednisone (mean +/- SD 29 +/- 45 versus 13 +/- 17 pg/ml; P = 0.008), and TNFalpha correlated with cumulated prednisone dose (r = 0.292, P = 0.04). Prednisone 167-177 interleukin 6 Homo sapiens 0-4 20656891-9 2010 We conclude that extracellular acidification stimulates IL-6 production and Ca(2+) mobilization through proton-sensing OGR1 receptors/G(q/11) proteins in human ASMCs. asmcs 160-165 interleukin 6 Homo sapiens 56-60 27025651-0 2016 MiR-26 down-regulates TNF-alpha/NF-kappaB signalling and IL-6 expression by silencing HMGA1 and MALT1. mir-26 0-6 interleukin 6 Homo sapiens 57-61 20615550-9 2010 In addition, triptolide (20ng/ml) in vitro was able to down-regulate the IL-6/STAT3 pathway and reduce IL-17 expression in cultured colonic explants from patients with Crohn"s disease (CD). triptolide 13-23 interleukin 6 Homo sapiens 73-77 20507366-5 2010 RESULTS: Ex vivo human whole blood assays indicated that triclosan significantly down-regulated the LPS-stimulated expression of Toll-like receptor signalling molecules and other multiple inflammatory molecules including IL-1 and IL-6 and the dampening of signals that activate the T-helper type 1 acquired immune response via suppression of CD70 with concomitant up-regulation of growth factors related to bone morphogenetic protein (BMP)2 and BMP6 synthesis. Triclosan 57-66 interleukin 6 Homo sapiens 230-234 26970310-4 2016 Furthermore, a knockdown of MTA1 by siRNA in the human fibroblast-like synovial cell line MH7A was found to impair the 4-hydroxynonenal (4-HNE)-induced transcriptional expression levels of certain proinflammatory cytokines including IL-1beta, TNF-alpha and IL-6. 4-hydroxy-2-nonenal 119-135 interleukin 6 Homo sapiens 257-261 22966296-0 2010 Down-regulation of IL-6, IL-8, TNF-alpha and IL-1beta by glucosamine in HaCaT cells, but not in the presence of TNF-alpha There is considerable evidence that glucosamine exerts an inhibitory effect on inflammatory cytokine expression in cells. Glucosamine 57-68 interleukin 6 Homo sapiens 19-23 22966296-0 2010 Down-regulation of IL-6, IL-8, TNF-alpha and IL-1beta by glucosamine in HaCaT cells, but not in the presence of TNF-alpha There is considerable evidence that glucosamine exerts an inhibitory effect on inflammatory cytokine expression in cells. Glucosamine 158-169 interleukin 6 Homo sapiens 19-23 22966296-5 2010 Our data showed that the expression of IL-6, IL-8, TNF-alpha and IL-1beta was decreased by glucosamine treatment in the HaCaT cells. Glucosamine 91-102 interleukin 6 Homo sapiens 39-43 22966296-9 2010 Our data indicated that glucosamine induced the down-regulation of IL-6, IL-8, TNF-alpha and IL-1beta expression in the HaCaT cells. Glucosamine 24-35 interleukin 6 Homo sapiens 67-71 20649610-7 2010 Moreover, iloprost dose dependently inhibited the secretion of TNF-alpha, IL-6, IL-8 and IL-12p70 in mDCs, while it enhanced IL-10 production. Iloprost 10-18 interleukin 6 Homo sapiens 74-78 26774572-5 2016 In addition, the anti-inflammatory properties of the modified Co-Cr surfaces were assessed by measuring IL-8 and IL-6 expression levels in human endothelial cell cultures. co-cr 62-67 interleukin 6 Homo sapiens 113-117 20206356-2 2010 The aim of this study was to test the effects of a short-course, high-dose oral prednisone on the release of interleukin-6 (IL-6) and tumour necrosis factor (TNF)-alpha from circulating monocytes and on the neointimal growth that follows bare metal stent (BMS) implantation. Prednisone 80-90 interleukin 6 Homo sapiens 109-122 20206356-2 2010 The aim of this study was to test the effects of a short-course, high-dose oral prednisone on the release of interleukin-6 (IL-6) and tumour necrosis factor (TNF)-alpha from circulating monocytes and on the neointimal growth that follows bare metal stent (BMS) implantation. Prednisone 80-90 interleukin 6 Homo sapiens 124-128 20206356-7 2010 RESULTS: Plasma concentrations of prednisone correlated inversely with IL-6 and TNF-alpha release (R2=0.45, p=0.04 and R2=0.69, p=0.005, respectively) and NF-kappaB activation from monocytes (R2=0.58, p=0.01). Prednisone 34-44 interleukin 6 Homo sapiens 71-75 20545201-8 2010 The levels of TNF-alpha and IL-6 were significantly higher than those of the control group after 1.0, 5.0, 10.0 mmol x L(-1) of polysaccharides of snakegourd root stimulation on the human PBMC at 8 hours (P < 0.05). Polysaccharides 128-143 interleukin 6 Homo sapiens 28-32 20545201-11 2010 The high levels of TNF-alpha and IL-6 are secreted after the polysaccharides of snakegourd root stimulation on the human PBMC, which lays a foundation for further elucidating the immunocompetence effects and mechanism of the polysaccharide of snakegourd root. Polysaccharides 61-76 interleukin 6 Homo sapiens 33-37 20545201-11 2010 The high levels of TNF-alpha and IL-6 are secreted after the polysaccharides of snakegourd root stimulation on the human PBMC, which lays a foundation for further elucidating the immunocompetence effects and mechanism of the polysaccharide of snakegourd root. Polysaccharides 61-75 interleukin 6 Homo sapiens 33-37 26929256-0 2016 Effects of Icodextrin and Glucose Bicarbonate/Lactate-Buffered Peritoneal Dialysis Fluids on Effluent Cell Population and Biocompatibility Markers IL-6 and CA125 in Incident Peritoneal Dialysis Patients. glucose-bicarbonate 26-45 interleukin 6 Homo sapiens 147-151 19645854-5 2010 Pretreatment with zileuton partially prevented the AA-induced LTB(4) and IL-6 release and increased neutral lipid content. zileuton 18-26 interleukin 6 Homo sapiens 73-77 19645854-6 2010 IL-6 release and neutral lipid content were also reduced under long-term zileuton treatment. zileuton 73-81 interleukin 6 Homo sapiens 0-4 21055228-8 2010 CONCLUSIONS: Free bile acids (CA, DCA and CDCA) can inhibit the expression of IL-6 and the cell viability, while glycine conjugates (GCA, GDCA and GCDCA) can promote the expression of IL-6 and the cell viability. Deoxycholic Acid 34-37 interleukin 6 Homo sapiens 78-82 26705248-9 2016 Post-exercise IL-6 differed between TC and HC, with significantly greater increases observed following HC (p < 0.05). Technetium 36-38 interleukin 6 Homo sapiens 14-18 20224557-8 2010 In addition, monocytes from hypertensive women homozygous for the 249Ser allele showed a lower release of tumor necrosis factor-alpha and interleukin-6 in response to zymosan (TLR6 agonist), but not to lipopolysaccharide (TLR4 agonist). Zymosan 167-174 interleukin 6 Homo sapiens 138-151 20061429-10 2010 Fenofibrate markedly decreased plasma high-sensitivity C-reactive protein by 49.5 +/- 8% (P = 0.005) and IL-6 by 29.8 +/- 7% (P = 0.03) vs. placebo. Fenofibrate 0-11 interleukin 6 Homo sapiens 105-109 26869854-10 2016 Noteworthy, the impaired TCA cycle in HT-1080 cells were associated with high mTORC1 activity, negligible protein level and activity of mTORC2, high expression of interleukin-1beta, interleukin-6 and heme oxygenase-1 which may contribute to the compensatory mechanism of TCA deficiency. Trichloroacetic Acid 25-28 interleukin 6 Homo sapiens 182-195 20145551-5 2010 We observed that BMDC, matured with a cytokine cocktail (tumor necrosis factor-alpha, interleukin-beta, interleukin-6, prostaglandin E2), strongly expressed CCR7. bmdc 17-21 interleukin 6 Homo sapiens 104-117 20056108-4 2010 We found that transfecting TE-5 and TE-9 cells with REG I Ialpha and Ibeta led to significantly increased expression of interleukin (IL)-6 mRNA and protein, but it had little or no effect on expression of IL-2, IL-4, IL-5, IL-10, IL-12, IL-13, IL-17A, interferon-gamma, tumor necrosis factor-alpha, granulocyte-colony stimulating factor or transforming growth factor-beta1. ibeta 69-74 interleukin 6 Homo sapiens 120-138 26788115-6 2016 DHA alone attenuated the secretion of pro-inflammatory adipokines such as chemerin, interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1/CCL2), whereas AC suppressed only the latter two. Docosahexaenoic Acids 0-3 interleukin 6 Homo sapiens 84-97 20439185-0 2010 Vitamin D derivatives: calcitriol and tacalcitol inhibits interleukin-6 and interleukin-8 expression in human nasal polyp fibroblast cultures. 1 alpha,24-dihydroxyvitamin D3 38-48 interleukin 6 Homo sapiens 58-71 20439185-3 2010 The purpose of this study was to investigate the influence of 1alpha,25-dihydroxyvitamin D3 (calcitriol) and 1alpha,24(R)-dihydroxyvitamin D3 (tacalcitol) on the secretion of IL-6 and IL-8 by fibroblasts derived from NP. Calcitriol 62-91 interleukin 6 Homo sapiens 175-179 20439185-3 2010 The purpose of this study was to investigate the influence of 1alpha,25-dihydroxyvitamin D3 (calcitriol) and 1alpha,24(R)-dihydroxyvitamin D3 (tacalcitol) on the secretion of IL-6 and IL-8 by fibroblasts derived from NP. 1 alpha,24-dihydroxyvitamin D3 109-141 interleukin 6 Homo sapiens 175-179 20439185-8 2010 RESULTS: Treatment with calcitriol or tacalcitol inhibits the synthesis of both IL-6 and IL-8 compared to the control group. Calcitriol 24-34 interleukin 6 Homo sapiens 80-84 20836843-9 2010 The capacity of P-Dex to suppress inflammation was confirmed in monocyte-macrophage cultures in which P-Dex treatment resulted in suppression of lipopolysaccharide-induced IL-6 and TNFalpha release. p-dex 16-21 interleukin 6 Homo sapiens 172-176 26788115-6 2016 DHA alone attenuated the secretion of pro-inflammatory adipokines such as chemerin, interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1/CCL2), whereas AC suppressed only the latter two. Docosahexaenoic Acids 0-3 interleukin 6 Homo sapiens 99-103 20836843-9 2010 The capacity of P-Dex to suppress inflammation was confirmed in monocyte-macrophage cultures in which P-Dex treatment resulted in suppression of lipopolysaccharide-induced IL-6 and TNFalpha release. p-dex 102-107 interleukin 6 Homo sapiens 172-176 20439185-8 2010 RESULTS: Treatment with calcitriol or tacalcitol inhibits the synthesis of both IL-6 and IL-8 compared to the control group. 1 alpha,24-dihydroxyvitamin D3 38-48 interleukin 6 Homo sapiens 80-84 20439185-12 2010 CONCLUSIONS: The present study demonstrates that calcitriol and tacalcitol are capable of affecting pro-inflammatory cytokine (IL-6 and IL-8) levels in NP cultures. Calcitriol 49-59 interleukin 6 Homo sapiens 127-131 26154696-8 2016 By promoting SIRT1 expression and stabilizing SIRT1-STAT3 interactions, H2S ameliorated IL-6-induced STAT3 acetylation, resulting in reduced hepcidin production. Hydrogen Sulfide 72-75 interleukin 6 Homo sapiens 88-92 20439185-12 2010 CONCLUSIONS: The present study demonstrates that calcitriol and tacalcitol are capable of affecting pro-inflammatory cytokine (IL-6 and IL-8) levels in NP cultures. 1 alpha,24-dihydroxyvitamin D3 64-74 interleukin 6 Homo sapiens 127-131 20514780-7 2010 The enhanced IL-6 values in group I, and maintained IL-6 values within reference range in group II, are the result of continuous tramadol chloride opiate analgesia, which turned out to be more efficient and safer. tramadol chloride 129-146 interleukin 6 Homo sapiens 13-17 20514780-7 2010 The enhanced IL-6 values in group I, and maintained IL-6 values within reference range in group II, are the result of continuous tramadol chloride opiate analgesia, which turned out to be more efficient and safer. tramadol chloride 129-146 interleukin 6 Homo sapiens 52-56 20571235-8 2010 A significantly positive correlation was observed between the IL-6 levels and conjugated dienes with the stage of breast carcinoma; whilst a significantly negative correlation was observed between the levels of conjugated dienes and superoxide dismutase and superoxide dismutase levels with the disease staging. dienes 89-95 interleukin 6 Homo sapiens 62-66 26391114-10 2016 Treatment with neat PTTC slightly reduced IL-6 levels and PTTC emulsion significantly reduced IL-6 levels to 92.53 +- 12.74 pg/ml compared to basal levels (141.69 +- 8.41 pg/ml). pttc 58-62 interleukin 6 Homo sapiens 94-98 19915063-5 2009 We found that iloprost inhibited IFN-gamma- and IL-6-induced MCP-1, IL-8, RANTES, and TNF-alpha production in monocytes, indicating wide-ranging anti-inflammatory action. Iloprost 14-22 interleukin 6 Homo sapiens 48-52 27980357-0 2016 Fermented Herbal Formulas KIOM-MA128 Ameliorate IL-6-Induced Intestinal Barrier Dysfunction in Colon Cancer Cell Line. ma128 31-36 interleukin 6 Homo sapiens 48-52 19810018-5 2009 Furthermore, naringin suppressed TNF-alpha-mediated release of interleukin-6 and -8 (IL-6 and IL-8). naringin 13-21 interleukin 6 Homo sapiens 63-83 19810018-5 2009 Furthermore, naringin suppressed TNF-alpha-mediated release of interleukin-6 and -8 (IL-6 and IL-8). naringin 13-21 interleukin 6 Homo sapiens 85-89 20840057-7 2010 Results demonstrate that the isolated Cyclo-pentano phenanthrenol inhibits TNF-alpha, IL-1beta and IL-6 expression, NO release via iNOS suppression, prostaglandin biosynthesis via PLA2 and COX-2 inhibition and the activation of intracellular targets, MAPK and NF-kappaB. cyclo-pentano phenanthrenol 38-65 interleukin 6 Homo sapiens 99-103 19051261-11 2009 The lymphocyte mitogen-induced proliferation, GR receptor on PBMC, and IL-6 plasma levels may represent a discriminating element between Cr(VI)-induced stress and other kinds of stress. chromium hexavalent ion 137-143 interleukin 6 Homo sapiens 71-75 27980357-7 2016 Interleukin-6 resulted in a dose-dependent decrease in the TER and an increase in the FITC-dextran permeability; however, pretreatment with 400 microg/ml KIOM-MA/MA128 resulted in a significant increase in the TER and a decrease in the FITC-dextran permeability via IL-6 induction. ma128 162-167 interleukin 6 Homo sapiens 0-13 27980357-7 2016 Interleukin-6 resulted in a dose-dependent decrease in the TER and an increase in the FITC-dextran permeability; however, pretreatment with 400 microg/ml KIOM-MA/MA128 resulted in a significant increase in the TER and a decrease in the FITC-dextran permeability via IL-6 induction. ma128 162-167 interleukin 6 Homo sapiens 266-270 25559945-9 2015 Plasma magnesium was positively correlated with catalase and glutathione peroxidase activities and with concentrations of interleukin-6 and tumor necrosis factor alpha. Magnesium 7-16 interleukin 6 Homo sapiens 122-167 20014600-0 2009 The effects of prostaglandin E1 on interleukin-6, pulmonary function and postoperative recovery in oesophagectomised patients. Alprostadil 15-31 interleukin 6 Homo sapiens 35-48 20014600-2 2009 We evaluated the effects of intraoperative infusion of prostaglandin E1 (PGE1) on interleukin-6 (IL-6) levels, (A-a) DO2, pulmonary function and complications. Alprostadil 55-71 interleukin 6 Homo sapiens 82-95 20014600-8 2009 Postoperatively, IL-6 levels were significantly higher in the placebo group than in the PGE1 group. Alprostadil 88-92 interleukin 6 Homo sapiens 17-21 20014600-10 2009 The findings indicate that infusion of PGE1 attenuates the increase in serum levels of IL-6 in patients undergoing esophagectomy and improves the (A-a) DO2. Alprostadil 39-43 interleukin 6 Homo sapiens 87-91 19535686-6 2009 S1P induced release of IL-6, a cytokine known to promote development of functionally mature MC(TC)s, from cord blood cultures containing adherent macrophages, and from highly purified macrophages, but not from macrophage-depleted CB-MCs. cb-mcs 230-236 interleukin 6 Homo sapiens 23-27 19575453-7 2009 In hepatocytes, insulin-stimulated glycogen synthesis and insulin-dependent phosphorylation of Akt-kinase were attenuated synergistically by prior incubation with IL-6 and/or PGE(2) while insulin receptor autophosphorylation was barely affected. Glycogen 35-43 interleukin 6 Homo sapiens 163-167 26467057-7 2015 The anti-inflammatory effect of TCE was mediated via reduction of the pro-inflammatory cytokines such as: IL-1beta, TNF-alpha, IL-6, and IL-17; the frequency of IL-17-producing T cells; and the production of chemokines such as RANTES. Trichloroethylene 32-35 interleukin 6 Homo sapiens 127-131 19779119-9 2009 Indeed, administration of neoadjuvant TAS appeared to bring about a marked elevation of IL-1beta and IL-6 and a significant reduction in TGFbeta when compared to patients receiving xRT alone. tas 38-41 interleukin 6 Homo sapiens 101-105 20214221-7 2009 Lovastatin administration resulted in the significant decrease of the pro-inflammatory cytokines IL-6 and TNF-alfa, while that of fluvastatin brought about the significant decrease of the serum levels of IL-6, IL-8 and TNF-alfa. Lovastatin 0-10 interleukin 6 Homo sapiens 97-101 20214221-10 2009 CONCLUSIONS: Lovastatin and fluvastatin, significantly decrease the level of viremia, of IL-6 and TNF-alpha in the patients with chronic hepatitis C. Lovastatin 13-23 interleukin 6 Homo sapiens 89-93 19779119-10 2009 CONCLUSION: The precise mechanisms underlying this TAS-related increase of the proinflammatory cytokines IL-1beta and IL-6 and decrease of the profibrotic cytokine TGFbeta remain unclear. tas 51-54 interleukin 6 Homo sapiens 118-122 26589393-11 2015 CONCLUSIONS: Serum levels of TNF-alpha, IL-6 and IL-18 were altered in chronic ketamine abusers which may play a role in schizophrenia-like symptoms in chronic ketamine abusers. Ketamine 79-87 interleukin 6 Homo sapiens 40-44 19465513-7 2009 TNFalpha-induced eotaxin, RANTES, and IL-6 as well as PDGF-BB-induced IL-6 expression was inhibited by DMF and by dexamethasone from asthmatic and nonasthmatic ASMC, but the combination of both drugs showed no glucocorticoid sparing effect in either of the two groups. asmc 160-164 interleukin 6 Homo sapiens 70-74 19783680-11 2009 Costimulation of monocytes with LPS and muramyl dipeptide induced an enhanced IL-6 response that was suppressed by siMAIL. Acetylmuramyl-Alanyl-Isoglutamine 40-57 interleukin 6 Homo sapiens 78-82 28793669-10 2015 Of great interest, the glutaraldehyde-crosslinked chitosan-coated collagen membranes promoted chondrocyte adhesion, growth, and interleukin (IL)-6 secretion. Glutaral 23-37 interleukin 6 Homo sapiens 128-146 19647751-3 2009 KEY FINDINGS: We showed that gAd induces the expression of a number of genes using PCR arrays, including MCP-1, VCAM-1, E-selectin, IL-6, and IL-8, all of which have been previously shown to be associated with adiponectin, as well as SOD2, PAI-1, and CSF2, which is a new finding. ganoderic acid D 29-32 interleukin 6 Homo sapiens 132-136 18640731-7 2009 SR maintenance was associated with lower baseline MDA values and faster decrease in IL-6, sICAM-1 and NT levels within the first 2 weeks following SR restoration. Strontium 0-2 interleukin 6 Homo sapiens 84-88 26358138-10 2015 Combination therapy of deferoxamine with pegylated interferon-alpha further improved all previous markers, ameliorated IL-6 elevation, as well as increased hepcidin expression. Deferoxamine 23-35 interleukin 6 Homo sapiens 119-123 19255163-8 2009 In addition, patients with DTS had significantly higher levels of IL-1beta, IL-6, TNF-alpha, and TGF-beta1 mRNA transcripts in their conjunctival epithelia than did the control subjects. dibenzyl trisulfide 27-30 interleukin 6 Homo sapiens 76-80 19501915-4 2009 The effects of calcitriol on synthesis of mRNAs encoding interleukin-6 (IL-6), interferon-gamma (IFN-gamma), and TNF-alpha were measured by real time RT-PCR. Calcitriol 15-25 interleukin 6 Homo sapiens 57-70 19501915-4 2009 The effects of calcitriol on synthesis of mRNAs encoding interleukin-6 (IL-6), interferon-gamma (IFN-gamma), and TNF-alpha were measured by real time RT-PCR. Calcitriol 15-25 interleukin 6 Homo sapiens 72-76 19307820-11 2009 Multivariate logistic regression comparing IL-6 and TBARS in terms of the relative risk for neonatal sepsis demonstrated that TBARS was a better predictor, being independently associated with neonatal sepsis. Thiobarbituric Acid Reactive Substances 126-131 interleukin 6 Homo sapiens 43-47 20436887-7 2009 Long-term treatment with Zileuton directly reduced the content of neutral lipids and interleukin-6 release from SZ95 seb ocytes. zileuton 25-33 interleukin 6 Homo sapiens 85-98 19321592-7 2009 Preincubation with fisetin and tricetin strongly attenuated LPS-induced increases in concentrations of TNFalpha in blood from COPD patients [mean (+/- SEM): -41 +/- 4% (fisetin) and -31 +/- 4% (tricetin); P < 0.001] and IL-6 in blood from T2D patients [-31 +/- 5% (fisetin) and -29 +/- 6% (tricetin); P < or = 0.001]. fisetin 19-26 interleukin 6 Homo sapiens 223-227 19101624-10 2009 IL-6 production induced by NiSO(4) and CoCl(2) strongly depended on all MAPKs. niso 27-31 interleukin 6 Homo sapiens 0-4 26390417-0 2015 Everolimus Improves Microcirculatory Derangements in Experimental Postischemic Pancreatitis Modulating the Expression of Vascular Endothelial Growth Factor, Interleukin 6, and Toll-Like Receptor 4. Everolimus 0-10 interleukin 6 Homo sapiens 157-170 18992869-5 2009 RESULTS: Tear concentrations of IL-6, IL-8 and TNF-alpha were significantly higher in DTS with and without MGD and EGF was significantly reduced in the DTS without MGD group compared with the control group. dibenzyl trisulfide 86-89 interleukin 6 Homo sapiens 32-36 19437484-4 2009 PEITC inhibited both constitutive and IL-6-induced STAT3 activity in DU145 cells. phenethyl isothiocyanate 0-5 interleukin 6 Homo sapiens 38-42 19437484-5 2009 IL-6-stimulated phosphorylation of JAK2, an STAT3 upstream kinase, was also attenuated by PEITC. phenethyl isothiocyanate 90-95 interleukin 6 Homo sapiens 0-4 19437484-6 2009 Moreover, an antioxidant reagent, N-acetyl-L-cysteine (NAC) which suppresses reactive oxygen species (ROS) generation, reversed the early inhibitory effects of PEITC on cell proliferation, constitutive or IL-6-mediated JAK-STAT3 phosphorylation in PCa cells. phenethyl isothiocyanate 160-165 interleukin 6 Homo sapiens 205-209 19437484-7 2009 Taken together, our data demonstrated that PEITC can inhibit the activation of the JAK-STAT3 signal-cascade in prostate cancer cells and the underlying mechanism may be partially involved with blocking cellular ROS production during the early stage of the signaling activation by IL-6. phenethyl isothiocyanate 43-48 interleukin 6 Homo sapiens 280-284 26460736-9 2015 Neutrophils treated with a2NTD (a2Neuphi) showed increased secretion of IL-1RA, IL-10, CCL-2 and IL-6 that are important mediators in cancer related inflammation. a2ntd 25-30 interleukin 6 Homo sapiens 97-101 19084239-14 2009 At every time point, circulating tumor necrosis factor alph, IL-1beta, and IL-6 were lower in animals receiving PG. pg 112-114 interleukin 6 Homo sapiens 75-79 19236332-6 2009 Therefore, cell-wall components of bacteria (lipopolysaccharide, muramyl dipeptide, diamino pimelic acid) stimulate IL-6 production in normal and tumoral pituitary. Acetylmuramyl-Alanyl-Isoglutamine 65-82 interleukin 6 Homo sapiens 116-120 19799786-11 2009 IL-6 was elevated in ATA-positive and ARA-positive patients, but not in ACA-positive patients. Aurintricarboxylic Acid 21-24 interleukin 6 Homo sapiens 0-4 26313265-7 2015 The WF harvested from patients underwent NAC showed significant higher profiles of interleukin-1beta (IL-1beta), IL-4, IL-6, IL-17F, IL-21, IL-23, IL-25, IL-31, Interferon gamma (IFNgamma), CD40 ligand (CD40L), tumor necrosis factor alpha (TNFalpha), CXCL1, CXCL2, CXCL5, CCL3, CCL7 and CCL20. nac 41-44 interleukin 6 Homo sapiens 119-123 19012752-6 2009 Concomitant inhibition of basal and interleukin-6-induced STAT3 activation was observed following pre-treatment with MGO. Pyruvaldehyde 117-120 interleukin 6 Homo sapiens 36-49 19285424-4 2009 OPN and IL-6 release in medium was increased in FCS with respect to RPMI (OPN: 13.9+/-2.9 vs. 2.3+/-0.8 microg/ml, p=0.0011; IL-6: 304.2+/-64.7 vs. 42.0+/-10.1 ng/ml, p<0.0006) as well as intima thickness, that positively correlated with OPN production (r=0.81). rpmi 68-72 interleukin 6 Homo sapiens 8-12 19321592-8 2009 Moreover, LPS-induced changes in TNFalpha and IL-6 concentrations were positively correlated with the extent of reduction by fisetin and tricetin. fisetin 125-132 interleukin 6 Homo sapiens 46-50 18515973-7 2009 Instead, this oxysterol slowed degradation of IL-6 mRNA and increased the amount of cytoplasmic HuR. Oxysterols 14-23 interleukin 6 Homo sapiens 46-50 26271488-0 2015 AZ17: a new bispecific drug targeting IL-6 and IL-23 with potential clinical use--improves psoriasis in a human xenograft transplantation model. az17 0-4 interleukin 6 Homo sapiens 38-42 19164258-7 2009 beta-Cryptoxanthin, lycopene, and lutein/zeaxanthin concentrations were inversely related to interleukin-6 concentrations. Zeaxanthins 41-51 interleukin 6 Homo sapiens 93-106 19444716-13 2009 RBC putrescine correlated with IL-6 and IL-10, and spermine correlated with CRP. Putrescine 4-14 interleukin 6 Homo sapiens 31-35 19434815-0 2009 Treatment with levamisole and colchicine can result in a significant reduction of IL-6, IL-8 or TNF-alpha level in patients with mucocutaneous type of Behcet"s disease. Colchicine 30-40 interleukin 6 Homo sapiens 82-86 18575957-1 2009 Aim The present study sought insight into the effects of remifentanyl and fentanyl on LPS-induced release of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and IL-10 in human whole blood. Remifentanil 57-69 interleukin 6 Homo sapiens 109-122 26445552-13 2015 Homozygous IL-6 -174C/C genotype carriers required higher doses of opioids than GG or GC carriers. gallocatechol 86-88 interleukin 6 Homo sapiens 11-15 18575957-4 2009 IL-6, TNF-alpha and IL-10 concentrations in activation groups treated with remifentanyl or fentanyl were significantly lower than those in LPS treated group (P < 0.05). Remifentanil 75-87 interleukin 6 Homo sapiens 0-4 18575957-6 2009 Conclusion Remifentanyl or fentanyl alone has no effects on IL-6, TNF-alpha and IL-10 production, but could attenuate LPS-induced IL-6,TNF-alpha and IL-10 production in human whole blood. Remifentanil 11-23 interleukin 6 Homo sapiens 130-134 18575957-7 2009 Remifentanyl and fentanyl could inhibit the expressions of IL-6, TNF-alpha and IL-10 induced by LPS. Remifentanil 0-12 interleukin 6 Homo sapiens 59-63 18951912-10 2009 Acrolein treatment led to activation and nuclear translocation of the transcription factor NF-kappaB and an increase in TNF-alpha, IL-6 and IL-8, but not MCP-1, mRNA. Acrolein 0-8 interleukin 6 Homo sapiens 131-135 26007240-5 2015 METHODS: The antiinflammation and antiproliferative activities of Di-cis-Py+ photoactivated was measured by myeloperoxidase (MPO) and N-acetyl-beta-d-glucosaminidase (NAG) enzyme activity assay, measurement of IL-6, IL-1beta and TNF-alpha levels, evaluation of proliferating cell nuclear antigen (PCNA) levels by immunohistochemistry and by Western blot. di-cis-py+ 66-76 interleukin 6 Homo sapiens 210-214 18848616-8 2008 In contrast, there were marked synergistic effects on IL-6 secretion when DC were cultured with DNBS and flagellin. dinitrobenzenesulfonic acid 96-100 interleukin 6 Homo sapiens 54-58 19068205-0 2008 [Effects of bisoprolol on serum interleukin-6 and tumor necrosis factor-alpha level in patients with congestive heart failure]. Bisoprolol 12-22 interleukin 6 Homo sapiens 32-45 19068205-7 2008 The level of serum IL-6 and TNF-alpha were decreased more significantly in the bisoprolol group than in the routine group (P<0.05 ) . Bisoprolol 79-89 interleukin 6 Homo sapiens 19-23 18998053-9 2009 Additionally, IL-6 concentrations were increased in both STB (median = 4.1 pg/ml, range 0.5-24) and MDRTB (median = 5.1 pg/ml, range 0.5-12) groups in relation to controls (p < 0.001). stb 57-60 interleukin 6 Homo sapiens 14-18 19139198-11 2009 The results demonstrate that C. jejuni surface polysaccharides induce IL-6 secretion from intestinal epithelial cells via TLR-2 in a MyD88-independent manner. Polysaccharides 47-62 interleukin 6 Homo sapiens 70-74 18654091-7 2009 Treatment with LQGV, AQGV, or LAGV prevented systemic release of TNF-[alpha] and IL-6 and was associated with reduced TNF-[alpha], IL-6, and E-selectin mRNA transcript levels in the liver. lqgv 15-19 interleukin 6 Homo sapiens 81-85 18654091-7 2009 Treatment with LQGV, AQGV, or LAGV prevented systemic release of TNF-[alpha] and IL-6 and was associated with reduced TNF-[alpha], IL-6, and E-selectin mRNA transcript levels in the liver. lqgv 15-19 interleukin 6 Homo sapiens 131-135 26285213-3 2015 To investigate whether IL-6 -174 G>C and TNF-alpha -376 G>A polymorphisms could be correlated to the incidence of FLS, and whether an anti-inflammatory/antipyretic therapy may influence FLS development, a prospective observational study was performed in 190 treatment naive, multiple sclerosis patients who started IM IFNbeta-1a 30mcg once weekly. CHEMBL1232769 120-123 interleukin 6 Homo sapiens 23-27 18835437-7 2009 In the vaccine/stress group, participants with larger IL-6 responses had heightened systolic blood pressure responses to tasks and elevated post-stress salivary levels of the noradrenaline metabolite 3-methoxy-phenyl glycol (MHPG) and cortisol. Methoxyhydroxyphenylglycol 225-229 interleukin 6 Homo sapiens 54-58 18804287-0 2008 Downregulation of IL-17 and IL-6 in the central nervous system by glatiramer acetate in experimental autoimmune encephalomyelitis. Glatiramer Acetate 66-84 interleukin 6 Homo sapiens 28-32 18804287-3 2008 We demonstrate that GA downregulates the expression of both IL-17 and IL-6 in two different EAE models. Glatiramer Acetate 20-22 interleukin 6 Homo sapiens 70-74 25384728-7 2015 In the T1DM group, IL6-174CC carriers showed higher concentrations of glycated hemoglobin (p = 0.029), albumin-to-creatinine ratio (p = 0.021), total cholesterol (p = 0.010), and LDL-cholesterol (p = 0.002), when compared with GG+GC carriers. gallocatechol 230-232 interleukin 6 Homo sapiens 19-22 18753925-8 2008 At baseline in a subset of patients with biomarker data, high sensitivity-C-reactive protein and interleukin-6 were 27% (P = 0.02) and 16% (P = 0.02) higher for patients receiving abacavir (N = 175) compared with those receiving other NRTIs (N = 500). abacavir 180-188 interleukin 6 Homo sapiens 97-110 19121950-12 2009 Overall results showed that exogenous farnesol promoted epithelial cell defense against C. albicans infection through the involvement of TLR2, IL-6, and human beta-defensin 2. Farnesol 38-46 interleukin 6 Homo sapiens 143-147 18948577-5 2009 SNX-2112 inhibits cytokine-induced Akt and extracellular signal-related kinase (ERK) activation and also overcomes the growth advantages conferred by interleukin-6, insulin-like growth factor-1, and bone marrow stromal cells. SNX 2112 0-8 interleukin 6 Homo sapiens 150-163 18689371-1 2008 BACKGROUND: Vitamin K modulates cytokines involved in bone turnover, including interleukin-6 (IL-6) and osteoprotegerin in vitro. Vitamin K 12-21 interleukin 6 Homo sapiens 79-92 26198966-9 2015 CONCLUSION: Intravenous injection of small-dose lidocaine and ketamine during the operation can reduce the incidence of POCD in elderly patients undergoing surgeries for gastrointestinal tumors possibly in relation to decreased serum S-100beta, NSE and IL-6 levels. Ketamine 62-70 interleukin 6 Homo sapiens 253-257 18689371-1 2008 BACKGROUND: Vitamin K modulates cytokines involved in bone turnover, including interleukin-6 (IL-6) and osteoprotegerin in vitro. Vitamin K 12-21 interleukin 6 Homo sapiens 94-98 18689371-2 2008 OBJECTIVE: The objective of this study was to assess 1) associations between measures of vitamin K status [plasma phylloquinone and serum percentage of undercarboxylated osteocalcin (%ucOC)] and IL-6, osteoprotegerin, and C-reactive protein (CRP) concentrations and 2) the effect of daily 500 mug phylloquinone supplementation for 3 y on cytokine concentrations. Vitamin K 89-98 interleukin 6 Homo sapiens 195-199 19136631-4 2009 Strong antigenic stimulation of T cells up-regulated CD40L expression, which in concert with certain microbial stimuli (i.e., cytosine phosphate guanine, curdlan, and zymosan) synergistically increased dendritic cell (DC) IL-6 production and Th17 polarization. cytosine phosphate guanine 126-152 interleukin 6 Homo sapiens 222-226 26942065-4 2016 Upon ibrutinib treatment, LPS-treated DCs displayed lower synthesis of TNF-alpha and nitric oxide (NO) and higher induction of IL-6, TGF-beta, IL-10 and IL-18. ibrutinib 5-14 interleukin 6 Homo sapiens 127-131 18797920-3 2009 The CBA detected IL-6 in 63% of pre-exercise samples and 84% of post-exercise samples; the ELISA detected IL-6 in all samples. cba 4-7 interleukin 6 Homo sapiens 17-21 18797920-6 2009 The CBA provided concordant IL-6 concentrations at rest, when detected, but underestimated exercise-induced increases in IL-6 versus the ELISA method. cba 4-7 interleukin 6 Homo sapiens 28-32 18797920-6 2009 The CBA provided concordant IL-6 concentrations at rest, when detected, but underestimated exercise-induced increases in IL-6 versus the ELISA method. cba 4-7 interleukin 6 Homo sapiens 121-125 18621420-6 2008 BK-mediated IL-6 production was attenuated by phospholipase C inhibitor (U73122), protein kinase Cdelta inhibitor (rottlerin), NF-kappaB inhibitor (PDTC), IkappaB protease inhibitor (TPCK) and NF-kappaB inhibitor peptide. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 73-79 interleukin 6 Homo sapiens 12-16 18424438-1 2008 In this study, we demonstrate that treatment of human lung adenocarcinoma H460 cells with farnesol induces the expression of a number of immune response and inflammatory genes, including IL-6, CXCL3, IL-1alpha, and COX-2. Farnesol 90-98 interleukin 6 Homo sapiens 187-191 26043379-7 2015 A negative correlation existed between the polyphenol concentration of the extracts and pro-inflammatory cytokines: Interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), prostaglandin (PGE2), and cyclooxygenase-2 (COX-2) enzyme. Polyphenols 43-53 interleukin 6 Homo sapiens 116-129 17869082-4 2008 Similar results were also found in cultured 3T3-L1 adipocytes; in addition, calcitriol also up-regulated macrophage colony-stimulating factor, macrophage inflammatory protein, interleukin-6 (IL-6) as well as monocyte chemoattractant protein-1 expression in 3T3-L1 adipocytes and stimulated tumor necrosis factor as well as IL-6 expression in RAW 264 macrophages. Calcitriol 76-86 interleukin 6 Homo sapiens 176-189 18717824-7 2008 Results Calcitriol decreased the adhesion molecules expression, as well as the LPS-induced mRNA expressions of RAGE and IL-6 and LPS induced IL-6 secretion. Calcitriol 8-18 interleukin 6 Homo sapiens 120-124 18717824-7 2008 Results Calcitriol decreased the adhesion molecules expression, as well as the LPS-induced mRNA expressions of RAGE and IL-6 and LPS induced IL-6 secretion. Calcitriol 8-18 interleukin 6 Homo sapiens 141-145 18717824-11 2008 CONCLUSIONS: The decreased NFkappaB and p38 activities followed by calcitriol treatment may explain the anti-inflammatory/atherosclerotic properties of calcitriol that were observed previously and were emphasized in this study, demonstrating the inhibitory effect of calcitriol on the pro-inflammatory parameters: adhesion molecules, RAGE and IL-6. Calcitriol 152-162 interleukin 6 Homo sapiens 343-347 18580350-0 2008 Combined therapeutic hypothermia and barbiturate coma reduces interleukin-6 in the cerebrospinal fluid after aneurysmal subarachnoid hemorrhage. barbituric acid 37-48 interleukin 6 Homo sapiens 62-75 17869082-4 2008 Similar results were also found in cultured 3T3-L1 adipocytes; in addition, calcitriol also up-regulated macrophage colony-stimulating factor, macrophage inflammatory protein, interleukin-6 (IL-6) as well as monocyte chemoattractant protein-1 expression in 3T3-L1 adipocytes and stimulated tumor necrosis factor as well as IL-6 expression in RAW 264 macrophages. Calcitriol 76-86 interleukin 6 Homo sapiens 191-195 18569862-4 2008 In the present study, we show that human peripheral blood mononuclear cells (PBMC) co-cultured with PG, in the presence of the inflammatory activator lipopolysaccharide, secreted higher amounts of pro-inflammatory and pro-angiogenic cytokines, such as interleukin (IL)-1beta, IL-6 and IL-8. pg 100-102 interleukin 6 Homo sapiens 276-280 26043379-7 2015 A negative correlation existed between the polyphenol concentration of the extracts and pro-inflammatory cytokines: Interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), prostaglandin (PGE2), and cyclooxygenase-2 (COX-2) enzyme. Polyphenols 43-53 interleukin 6 Homo sapiens 131-135 25840995-0 2015 TGF-beta-induced IL-6 prevents development of acute lung injury in influenza A virus-infected F508del CFTR-heterozygous mice. f508del 94-101 interleukin 6 Homo sapiens 17-21 18271757-0 2008 Prostaglandin E1 inhibits IL-6-induced MCP-1 expression by interfering specifically in IL-6-dependent ERK1/2, but not STAT3, activation. Alprostadil 0-16 interleukin 6 Homo sapiens 26-30 18271757-0 2008 Prostaglandin E1 inhibits IL-6-induced MCP-1 expression by interfering specifically in IL-6-dependent ERK1/2, but not STAT3, activation. Alprostadil 0-16 interleukin 6 Homo sapiens 87-91 18500730-8 2008 Additionally, IL-6 mRNA and protein expression was assessed both in qualitative (by in situ hybridization and immunohistochemistry) and in quantitative (by real-time PCR and Western blot) approaches, in control and hypoplastic lungs (nitrofen and CDH groups). nitrofen 234-242 interleukin 6 Homo sapiens 14-18 18500730-11 2008 Although more exacerbated in CDH, both nitrofen-exposed lungs presented significant IL-6 mRNA and protein over-expression throughout all studied gestational ages. nitrofen 39-47 interleukin 6 Homo sapiens 84-88 26205020-13 2015 Changes in IL-6 levels positively and significantly correlated with change in neopterin levels. Neopterin 78-87 interleukin 6 Homo sapiens 11-15 17869082-4 2008 Similar results were also found in cultured 3T3-L1 adipocytes; in addition, calcitriol also up-regulated macrophage colony-stimulating factor, macrophage inflammatory protein, interleukin-6 (IL-6) as well as monocyte chemoattractant protein-1 expression in 3T3-L1 adipocytes and stimulated tumor necrosis factor as well as IL-6 expression in RAW 264 macrophages. Calcitriol 76-86 interleukin 6 Homo sapiens 323-327 18271757-7 2008 In the present study, we have investigated the inhibitory activity of PGE(1) (prostaglandin E(1)) on IL-6-induced MCP-1 expression and have elucidated the underlying molecular mechanism. Alprostadil 70-76 interleukin 6 Homo sapiens 101-105 18271757-7 2008 In the present study, we have investigated the inhibitory activity of PGE(1) (prostaglandin E(1)) on IL-6-induced MCP-1 expression and have elucidated the underlying molecular mechanism. Alprostadil 78-96 interleukin 6 Homo sapiens 101-105 18434350-7 2008 A comparison between conventional end point assays and real-time measurement showed similar effects for dexamethasone and hydrocortisone, with a less effective inhibition of IL-6 seen with corticosterone. Corticosterone 189-203 interleukin 6 Homo sapiens 174-178 18205904-13 2008 CONCLUSION: In human colon carcinoma cells derived from well and moderately differentiated tumours, IL-6 expression is low and only marginally affected, if at all, by PGE2, 1,25-dihydroxyvitamin D3, and 17beta-estradiol. Calcitriol 173-197 interleukin 6 Homo sapiens 100-104 25873160-6 2015 H2S inhibited the production of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in a concentration-dependent manner; it was most effective at the two highest concentrations used. Hydrogen Sulfide 0-3 interleukin 6 Homo sapiens 32-45 18209571-6 2008 IL-6 promoter activity was diminished by U0126 or SB202190, but not by SP600125. U 0126 41-46 interleukin 6 Homo sapiens 0-4 17920534-3 2007 While SA981 partially inhibited IL-1beta-induced VEGF production at concentrations of 10 to 100 microM (10.1% and 14.2% inhibition of total VEGF production under IL-1beta coexistence condition, respectively), it failed to inhibit IL-1beta-induced IL-6 production at the same concentrations. bucillamine disulfide 6-11 interleukin 6 Homo sapiens 247-251 17561367-3 2007 When cells were exposed to SR, syringin, or isofraxidin, only isofraxidin had significant inhibitory effects on cell growth, although a slight inhibition was observed at the highest concentration of SR. SR suppressed the production of IL-6 at lower concentrations than syringin and isofraxidin. Strontium 27-29 interleukin 6 Homo sapiens 235-239 18353875-8 2008 The parallel elevation of interleukin-6 mRNA in the presence of AGE-HSA was also blunted by calcitriol. Calcitriol 92-102 interleukin 6 Homo sapiens 26-39 25873160-6 2015 H2S inhibited the production of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in a concentration-dependent manner; it was most effective at the two highest concentrations used. Hydrogen Sulfide 0-3 interleukin 6 Homo sapiens 47-51 18471410-8 2008 The plasma levels of IL-1alpha, IL-6 and TNF-alpha in low-protein diet plus alpha-keto acid group were decreased as compared with the routine-protein diet group, but there were no significant differences. alpha-keto acid 76-91 interleukin 6 Homo sapiens 32-36 17561367-3 2007 When cells were exposed to SR, syringin, or isofraxidin, only isofraxidin had significant inhibitory effects on cell growth, although a slight inhibition was observed at the highest concentration of SR. SR suppressed the production of IL-6 at lower concentrations than syringin and isofraxidin. Strontium 199-201 interleukin 6 Homo sapiens 235-239 17561367-5 2007 SR was more potent than syringin and isofraxidin at inhibiting the expression of IL-1beta, IL-6, cyclooxygenase (COX)-2 and matrix metalloproteinases (MMP)-1 mRNA, but was less potent than syringin at inhibiting the expression of MMP-2. Strontium 0-2 interleukin 6 Homo sapiens 91-95 18062909-6 2008 Thrombin-mediated IL-6 production was attenuated by thrombin inhibitor (PPACK), phospholipase C inhibitor (U73122), protein kinase C alpha inhibitor (Ro320432), Src inhibitor (PP2), NF-kappaB inhibitor (PDTC), I kappa B protease inhibitor (TPCK), or NF-kappaB inhibitor peptide. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 107-113 interleukin 6 Homo sapiens 18-22 25873160-7 2015 This effect was associated with a decrease in histone H3 acetylation at the IL-6 and TNF-alpha promoters in the cells exposed to H2S or H2S + LPS. Hydrogen Sulfide 129-132 interleukin 6 Homo sapiens 76-80 25873160-7 2015 This effect was associated with a decrease in histone H3 acetylation at the IL-6 and TNF-alpha promoters in the cells exposed to H2S or H2S + LPS. Hydrogen Sulfide 136-139 interleukin 6 Homo sapiens 76-80 26604933-17 2015 Clodronate at small doses (2 mg) could also have protective effects on cartilage (introduction of intra-articular formulation is expected) and at 10-100 fold higher doses it has certainly anti-inflammatory effects and more specifically antimacrophage and anticytokine effects (IL-1, IL-6, TNFalpha, PGE). Clodronic Acid 0-10 interleukin 6 Homo sapiens 283-287 17346285-0 2008 Interleukin-6 and its mRNA responses in exercise and recovery: relationship to muscle glycogen. Glycogen 86-94 interleukin 6 Homo sapiens 0-13 17346285-1 2008 Increases in circulating interleukin-6 (IL-6) during exhaustive exercise have been suggested to be related to declining muscle glycogen. Glycogen 127-135 interleukin 6 Homo sapiens 25-38 17346285-1 2008 Increases in circulating interleukin-6 (IL-6) during exhaustive exercise have been suggested to be related to declining muscle glycogen. Glycogen 127-135 interleukin 6 Homo sapiens 40-44 17346285-2 2008 We addressed two hypotheses: (a) exhaustive exercise on two occasions will result in similar decreases in glycogen and increases in circulating IL-6 and its muscle mRNA; (b) increasing the rate of glycogen restoration via high-carbohydrate feeding in recovery will be associated with more rapid declines in muscle mRNA and circulating IL-6. Glycogen 197-205 interleukin 6 Homo sapiens 335-339 18510246-13 2008 These inhibitory effects were significant at both the mRNA and protein levels (protein of IL-6: t1h = 7.9154, t2h = 10.863, t4h = 8.2451, t8h = 13.5063. protein of IL-8: t1h = 8.5663, t2h = 20.5169, t4h = 25.1580, t8h = 34.8699. mRNA of IL-6: t1h = 12.0235, t2h = 13.2894, t4h = 24.0799, t8h = 27.2261. mRNA of IL-8: t1h = 20.9424, t2h = 24.1314, t4h = 29.8580, t8h = 47.9442. t8h 138-141 interleukin 6 Homo sapiens 90-94 18510246-13 2008 These inhibitory effects were significant at both the mRNA and protein levels (protein of IL-6: t1h = 7.9154, t2h = 10.863, t4h = 8.2451, t8h = 13.5063. protein of IL-8: t1h = 8.5663, t2h = 20.5169, t4h = 25.1580, t8h = 34.8699. mRNA of IL-6: t1h = 12.0235, t2h = 13.2894, t4h = 24.0799, t8h = 27.2261. mRNA of IL-8: t1h = 20.9424, t2h = 24.1314, t4h = 29.8580, t8h = 47.9442. t8h 214-217 interleukin 6 Homo sapiens 90-94 17867636-9 2007 This anti-inflammatory effect of alpha-terpineol on IL-6 formation was verified by quantitative real-time reverse transcription Polymerase Chain Reaction experiments in which alpha-terpineol inhibited the gene expression of the IL-6 receptor. alpha-terpineol 33-48 interleukin 6 Homo sapiens 52-56 17867636-9 2007 This anti-inflammatory effect of alpha-terpineol on IL-6 formation was verified by quantitative real-time reverse transcription Polymerase Chain Reaction experiments in which alpha-terpineol inhibited the gene expression of the IL-6 receptor. alpha-terpineol 33-48 interleukin 6 Homo sapiens 228-232 17867636-9 2007 This anti-inflammatory effect of alpha-terpineol on IL-6 formation was verified by quantitative real-time reverse transcription Polymerase Chain Reaction experiments in which alpha-terpineol inhibited the gene expression of the IL-6 receptor. alpha-terpineol 175-190 interleukin 6 Homo sapiens 52-56 17867636-9 2007 This anti-inflammatory effect of alpha-terpineol on IL-6 formation was verified by quantitative real-time reverse transcription Polymerase Chain Reaction experiments in which alpha-terpineol inhibited the gene expression of the IL-6 receptor. alpha-terpineol 175-190 interleukin 6 Homo sapiens 228-232 17617741-4 2007 In these studies, the effect of 5alpha-dihydrotestosterone (DHT) on the expression levels of IL-6 and IL-8 was investigated. Dihydrotestosterone 32-58 interleukin 6 Homo sapiens 93-97 17617741-4 2007 In these studies, the effect of 5alpha-dihydrotestosterone (DHT) on the expression levels of IL-6 and IL-8 was investigated. Dihydrotestosterone 60-63 interleukin 6 Homo sapiens 93-97 17617741-8 2007 Furthermore, DHT enhanced IL-6 and IL-8 secretion. Dihydrotestosterone 13-16 interleukin 6 Homo sapiens 26-30 25546398-11 2015 In summary, we found that A2A and P2X7 activation is necessary for IL-10, MCP-1, and IL-6 release by macrophages exposed to GL-CM, which, in turn, modulates the macrophages to M2-phenotype. glycylleucine 124-126 interleukin 6 Homo sapiens 85-89 17617741-10 2007 IL-6- or IL-8-induced cell proliferation was completely blocked by their specific neutralizing antibodies, which partially inhibited DHT-induced cell growth. Dihydrotestosterone 133-136 interleukin 6 Homo sapiens 0-13 17363741-10 2007 IL-6 also increased skeletal muscle glucose incorporation into glycogen, as well as glucose oxidation (1.5- and 1.3-fold, respectively; P < 0.05). Glycogen 63-71 interleukin 6 Homo sapiens 0-4 18075466-0 2007 Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity. Tacrine 54-61 interleukin 6 Homo sapiens 37-50 18075466-13 2007 CONCLUSION: The IL6 genotype may act as a predisposing factor for tacrine transaminitis. Tacrine 66-73 interleukin 6 Homo sapiens 16-19 25626894-9 2015 The present findings suggest that GEN protects HCY-induced endothelial cell inflammatory injury may through reducing the release of ROS, inhibiting NF-kB activation, down-regulating the expression of cytokine IL-6 and adhesion molecules ICAM-1, avoiding inflammatory cells and platelet adhesion, accordingly, leading to a balance of endothelial cell proliferation and apoptosis. Homocysteine 47-50 interleukin 6 Homo sapiens 209-213 17636246-3 2007 In this work, we showed that NiSO(4) induced the expression of HLA-DR, CD83, CD86, and CD40 and the production of interleukin (IL)-8, IL-6, and IL-12p40 in human DCs, whereas DNCB induced mainly the expression of CD83 and CD86 and the production of IL-8. niso 29-33 interleukin 6 Homo sapiens 134-138 25995631-0 2015 Oxidative stress by layered double hydroxide nanoparticles via an SFK-JNK and p38-NF-kappaB signaling pathway mediates induction of interleukin-6 and interleukin-8 in human lung epithelial cells. double 28-34 interleukin 6 Homo sapiens 132-145 17615159-7 2007 Pharmacological activation of AMPK with 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside upregulated IL-6 mRNA expression, which was blocked by knockdown of AMPK alpha(1) and alpha(2) using small, interfering RNA (siRNA) oligonucleotides. 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside 40-94 interleukin 6 Homo sapiens 107-111 17453721-10 2007 The decreased serum concentration of IL-6, APP and SLEDAI score observed during applied therapy with small dose of quinagolide confirms the hypothesis that quinagolide may become a valuable and safe drug in the therapy of patients with mild SLE. quinagolide 115-126 interleukin 6 Homo sapiens 37-41 17453721-10 2007 The decreased serum concentration of IL-6, APP and SLEDAI score observed during applied therapy with small dose of quinagolide confirms the hypothesis that quinagolide may become a valuable and safe drug in the therapy of patients with mild SLE. quinagolide 156-167 interleukin 6 Homo sapiens 37-41 17652834-0 2007 Influence of preventive therapy with quinapril on IL-6 level in patients with chronic stable angina. Quinapril 37-46 interleukin 6 Homo sapiens 50-54 17652834-2 2007 For that reason, we have investigated the influence of short-term administration of quinapril on serum IL-6 concentration. Quinapril 84-93 interleukin 6 Homo sapiens 103-107 26117985-6 2015 IL-6 concentrations were significantly higher in the VH group than the TLH group (p=0.00 1). CHEMBL4454335 71-74 interleukin 6 Homo sapiens 0-4 17652834-7 2007 We observed that quinapril reduced serum IL-6 concentration in almost all studied subgroups of patients (p < 0.001). Quinapril 17-26 interleukin 6 Homo sapiens 41-45 17652834-10 2007 In conclusion, quinapril may interfere with cytokine release by lowering IL-6 levels, which may be of particular importance for secondary prevention of stable CAD. Quinapril 15-24 interleukin 6 Homo sapiens 73-77 17584482-9 2007 This study showed that application of ZBUF is more effective to decrease the level of inflammatory mediators including TNF-alpha, IL-6, and IL-8 than administration of MP after pediatric CPB. zbuf 38-42 interleukin 6 Homo sapiens 130-134 17453721-0 2007 Selected acute phase proteins and interleukin-6 in systemic lupus erythematosus patients treated with low doses of quinagolide. quinagolide 115-126 interleukin 6 Homo sapiens 34-47 25502581-10 2015 Losartan can also enhance adiponectin (P<0.05) and decrease TNF-alpha (P<0.05) and IL-6 (P<0.01) secretion, while amlodipine can not. Losartan 0-8 interleukin 6 Homo sapiens 89-93 17394854-6 2007 sTNFRI, IL-1Ra and ICAM-1 early showed significantly higher levels in relation with serum creatinine, and these and also IL-6 in those with PO2 below 60 mmHg. PO-2 140-143 interleukin 6 Homo sapiens 121-125 17353005-7 2007 Further study shows that the apoE isoform-dependent variations of TNF-alpha and IL-6 expression/secretion in macrophages are diminished in the presence of ERK1/2 inhibitor U0126. U 0126 172-177 interleukin 6 Homo sapiens 80-84 16860297-7 2007 Exposure to the photochemically generated products of BD (primarily acrolein, acetaldehyde, formaldehyde, furan and ozone) induced significant increases in cytotoxicity, IL-8, and IL-6 gene expression compared to a synthetic mixture of primary products that was created by injecting the correct concentrations of the detected products from the irradiation experiments. Acrolein 68-76 interleukin 6 Homo sapiens 180-184 17078813-9 2007 Inhibition with siRNA (small interfering RNA) targeting the SFK Lck, but not dominant-negative JAK (Janus kinase), prevented Cr(VI)-stimulated phosphorylation of both STAT3 isoforms and induction of IL-6. chromium hexavalent ion 125-131 interleukin 6 Homo sapiens 199-203 17326846-2 2007 This study measured cytotoxicity and the release of the proinflammatory cytokines IL-6 and IL-8 by human bronchial epithelial cells treated with manufactured nano- and micron-sized particles of Al2O3, CeO2, Fe2O3, NiO, SiO2, and TiO2, with soil-derived particles from fugitive dust sources, and with the positive controls LPS, TNF-alpha, and VOSO4. Aluminum Oxide 194-199 interleukin 6 Homo sapiens 82-86 24584621-6 2015 The HD modality (standard beta = 0.57, p < 0.001) and dialysis vintage (standard beta = 0.12, p = 0.02) were independent predictors of serum 8-OHdG in a multivariable linear regression model including age, sex, body mass index, dialysis modality (HD or PD), preceding time on dialysis (dialysis vintage), PEW, comorbidity score, IL-6, and use of angiotensin converting-enzyme inhibitors or angiotensin II receptor blockers or statins. 8-ohdg 144-150 interleukin 6 Homo sapiens 332-336 16530440-1 2007 Anti-inflammatory effect of desloratadine (DL), including, but not limited to depression of production of IL-4, IL-6 and IL-8, has been shown in several in vitro experiments but only a few in vivo studies refer to this findings. desloratadine 28-41 interleukin 6 Homo sapiens 112-116 16530440-1 2007 Anti-inflammatory effect of desloratadine (DL), including, but not limited to depression of production of IL-4, IL-6 and IL-8, has been shown in several in vitro experiments but only a few in vivo studies refer to this findings. desloratadine 43-45 interleukin 6 Homo sapiens 112-116 17286808-8 2007 In addition, secretion of proinflammatory mediators such as the cytokines interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF alpha), IL-6 and IL-8 were inhibited in the presence of physiological doses of OMZ. Oxymetazoline 216-219 interleukin 6 Homo sapiens 145-149 17130674-7 2006 However, AG1478, an epidermal growth factor (EGF)-receptor inhibitor, partially decreased UTP-induced ERK phosphorylation and IL-6 expression. Uridine Triphosphate 90-93 interleukin 6 Homo sapiens 126-130 17130674-8 2006 These results suggest that UTP-induced IL-6 production is in part mediated via phosphorylation of ERK through G(q/11)/IP(3)/[Ca(2+)](i) and transactivation of the EGF receptor. Uridine Triphosphate 27-30 interleukin 6 Homo sapiens 39-43 16945991-4 2006 IL-6 increased glucose incorporation into glycogen, glucose uptake, lactate production, and fatty acid uptake and oxidation, concomitant with increased phosphorylation of AMP-activated protein kinase (AMPK), signal transducer and activator of transcription 3, and ERK1/2. Glycogen 42-50 interleukin 6 Homo sapiens 0-4 16945991-8 2006 In summary, IL-6 increases glycogen synthesis via a PI3-kinase-dependent mechanism and enhances lipid oxidation via an AMPK-dependent mechanism in skeletal muscle. Glycogen 27-35 interleukin 6 Homo sapiens 12-16 16945991-9 2006 Thus, IL-6 directly promotes skeletal muscle differentiation and regulates muscle substrate utilization, promoting glycogen storage and lipid oxidation. Glycogen 115-123 interleukin 6 Homo sapiens 6-10 18040816-5 2006 Suppression of IL-6, but not IL-12, production by EtOH was found to be mediated by corticosterone. Corticosterone 83-97 interleukin 6 Homo sapiens 15-19 25263526-5 2015 During the 5 days preceding delivery, median CRP, WBC, and IL-6 levels were significantly higher in the HCA than in no-HCA group (P < 0.001). hca 104-107 interleukin 6 Homo sapiens 59-63 17014550-11 2006 In the HVHF group there was a positive association between the IL-6 levels at 6 h with the SOFA scores at day 1 (r = 0.392, P = 0.001) but not at day 7. hvhf 7-11 interleukin 6 Homo sapiens 63-67 16954375-11 2006 These results indicate that AUF1 binds to the AU-rich element in vivo and promotes IL-6 mRNA degradation. Gold 28-30 interleukin 6 Homo sapiens 83-87 26817117-5 2015 STUDY RESULTS: In overall, the results of this work suggest that long-term, for 12 months, losartan usage in a daily dose of 50 mg in the complex therapy of patients with NASH is followed by a significant decrease in the levels of tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) in serum and improvement in 13C-metathetin breath test results. Losartan 91-99 interleukin 6 Homo sapiens 275-288 16924534-5 2006 In contrast, PGD(2) induced a marked stimulation of IL-6 and MCP-1 expression; with IL-6, this was rapid, the mRNA level increasing by >50-fold by 1 h. The rise in mRNA was accompanied by an increase in IL-6 and MCP-1 release (up to 100- and 6.5-fold, respectively). Prostaglandin D2 13-19 interleukin 6 Homo sapiens 84-88 16924534-6 2006 The effects of PGD(2) were generally mirrored by PGJ(2) and Delta(12)-PGJ(2); Delta(12)-PGJ(2) was a particularly strong stimulator of IL-6 production. Prostaglandins D 15-18 interleukin 6 Homo sapiens 135-139 16936090-10 2006 CONCLUSIONS: Triptolide inhibits the LPS-induced expression of IL-6, chemokines (G-CSF, MCP-1, IL-8), and ICAM-1 in cultured human corneal fibroblasts. triptolide 13-23 interleukin 6 Homo sapiens 63-67 16936090-6 2006 Triptolide and dexamethasone each inhibited in a concentration-dependent manner the LPS-induced release of IL-6, G-CSF, MCP-1, and IL-8 by corneal fibroblasts. triptolide 0-10 interleukin 6 Homo sapiens 107-111 16952593-8 2006 Taurine level in group GT was higher than in group G. Arginine and citrulline levels in groups G and GT were lower than in group C. Taurine level in the small intestine was greater in group GT than in group G. Citrulline concentration was lower in group G than in groups GT and C. Endotoxin level in portal blood and cytokine (tumor necrosis factor alpha, interleukin-1beta, and interleukin-6) levels in blood tended to be lower for group GT than for group G, but no significant differences were noted. Citrulline 210-220 interleukin 6 Homo sapiens 379-392 26817117-5 2015 STUDY RESULTS: In overall, the results of this work suggest that long-term, for 12 months, losartan usage in a daily dose of 50 mg in the complex therapy of patients with NASH is followed by a significant decrease in the levels of tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) in serum and improvement in 13C-metathetin breath test results. Losartan 91-99 interleukin 6 Homo sapiens 290-294 26328657-5 2015 After switching from AZ to MMF, her symptoms of NPSLE completely resolved with marked improvement of the IL-6 level in her spinal fluid, suggesting that MMF was effective. Azathioprine 21-23 interleukin 6 Homo sapiens 105-109 16769764-0 2006 IL-6 and IL-8 release is mediated via multiple signaling pathways after stimulating dendritic cells with lysophospholipids. Lysophospholipids 105-122 interleukin 6 Homo sapiens 0-4 18603920-9 2006 Recently, another substance known as Cytokines e.g. IL-6, Tumour necrosis factor (TNF), have also been labelled to be responsible for depressed excretory function of liver and may lead to increase in SB level without rise in liver enzymes. Antimony 200-202 interleukin 6 Homo sapiens 52-56 16532021-6 2006 The p38 inhibitor SB203580 and the PKC inhibitors Calphostin C and Go6976 completely inhibited IL-1-induced IL-6 production. Go 6976 67-73 interleukin 6 Homo sapiens 108-112 26328657-5 2015 After switching from AZ to MMF, her symptoms of NPSLE completely resolved with marked improvement of the IL-6 level in her spinal fluid, suggesting that MMF was effective. Mycophenolic Acid 27-30 interleukin 6 Homo sapiens 105-109 16532021-7 2006 Quercetin 1-100 microM inhibited IL-1-induced IL-6 secretion, p38 and PKC-theta phosphorylation in a dose-dependent manner. quercetin 1 0-11 interleukin 6 Homo sapiens 46-50 16501050-8 2006 Zymosan induced the expression of tumor necrosis factor alpha (TNF-alpha), TNF-beta, IL-10, IL-6, and MCP-2/CCL8, whereas the cytokine signature of C3bi-coated zymosan also included interferon-inducible protein 10/CXC chemokine ligand 10, platelet-derived growth factor-BB, and I-309/CCL1. Zymosan 0-7 interleukin 6 Homo sapiens 92-96 16765939-1 2006 We examined whether the 22beta-methoxyolean-12-ene-3beta,24(4beta)-diol (ME3738)-mediated selective induction of interleukin-6 increased alpha1-acid glycoprotein and serum amyloid A expression, and whether these proteins protected against liver injury in vitro and in vivo. 22beta-methoxyolean-12-ene-3beta 24-56 interleukin 6 Homo sapiens 113-126 24806275-2 2015 The goal of this study was to investigate the potential for Mn(2+), via its pro-oxidative properties, to activate production of pro-inflammatory cytokines/chemokines IL-1beta, IL-6, IL-8, IFNgamma, TNFalpha, and G-CSF by human monocyte-derived macrophages in vitro. Manganese(2+) 60-66 interleukin 6 Homo sapiens 176-180 16859116-4 2006 CONCLUSION: Xipayi mouth rinse can inhibit the secretion of IL-6 from HGF induced by LPS, suggesting the anti-inflammatory effect of xipayi mouth rinse to treat and prevent periodontal diseases. xipayi mouth rinse 12-30 interleukin 6 Homo sapiens 60-64 16354768-0 2006 Janus kinase-signal transducer and activator of transcription mediates phosphatidic acid-induced interleukin (IL)-1beta and IL-6 production. Phosphatidic Acids 71-88 interleukin 6 Homo sapiens 124-128 16354768-2 2006 In the present study, we provide evidence of the PA-mediated activation of the Janus tyrosine kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway, which results in the production of interleukin (IL)-1beta and IL-6. Phosphatidic Acids 49-51 interleukin 6 Homo sapiens 244-248 16539678-3 2006 We herein report that sulfated polymannuroguluronate (SPMG), a novel anti-acquired immunodeficiency syndrome drug candidate now in a phase II clinical trial, significantly reversed Tat-induced release of pro-inflammatory cytokines [tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta) and IL-6] and dose dependently decreased the accumulation of reactive oxygen species and nitric oxide in THP-1 cells. polymannuroguluronate 31-52 interleukin 6 Homo sapiens 296-300 16278310-3 2006 Both, in the absence and presence of myeloma-stroma cell contacts, BIBF 1000 abrogated BMSC-derived secretion of interleukin-6 (IL-6). BIBF 1000 67-76 interleukin 6 Homo sapiens 113-126 16278310-3 2006 Both, in the absence and presence of myeloma-stroma cell contacts, BIBF 1000 abrogated BMSC-derived secretion of interleukin-6 (IL-6). BIBF 1000 67-76 interleukin 6 Homo sapiens 128-132 16354768-7 2006 The knockdown of JAK2 in macrophages by small interfering RNA significantly attenuated PA-induced IL-1beta and IL-6 production. Phosphatidic Acids 87-89 interleukin 6 Homo sapiens 111-115 16354768-5 2006 Of the inflammatory cytokines, IL-1beta, IL-6, and tumor necrosis factor (TNF)-alpha were detected in media from macrophages stimulated with PA. Phosphatidic Acids 141-143 interleukin 6 Homo sapiens 41-45 24939558-8 2015 The serum levels of IL-2, IL-10, IL-21, IL-22 and TNF-alpha were not significantly different between the two groups (p > 0.05), but the level of IL-6 was higher in JA group (p < 0.001). jiangrine A 167-169 interleukin 6 Homo sapiens 148-152 16354768-6 2006 Moreover, the JAK2 inhibitor alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide (AG-490) abolished PA-induced IL-1beta and IL-6 release but not TNF-alpha production, which is consistent with the notion that IL-1beta and IL-6 but not TNF-alpha contain a STAT binding element in their promoter region. Phosphatidic Acids 94-96 interleukin 6 Homo sapiens 118-122 16354768-6 2006 Moreover, the JAK2 inhibitor alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide (AG-490) abolished PA-induced IL-1beta and IL-6 release but not TNF-alpha production, which is consistent with the notion that IL-1beta and IL-6 but not TNF-alpha contain a STAT binding element in their promoter region. Phosphatidic Acids 94-96 interleukin 6 Homo sapiens 215-219 16354768-9 2006 Together, our data demonstrate that PA-activated macrophages produce IL-1beta and IL-6 and that these processes require the activation of the JAK2-STAT1/3 or JAK2-Akt-STAT signaling pathways. Phosphatidic Acids 36-38 interleukin 6 Homo sapiens 82-86 16317058-8 2006 In addition, DHT inhibited mRNA expression of IL-6, MCP-1, CD40, TLR4, PAI-1, and Cox-2 and the release of cytokines and chemokines such as GRO, granulocyte-macrophage colony-stimulating factor, and TNF. Dihydrotestosterone 13-16 interleukin 6 Homo sapiens 46-50 24939558-9 2015 The serum level of IL-6 might have a correlation with JA secondary to SLE. jiangrine A 54-56 interleukin 6 Homo sapiens 19-23 25522414-8 2014 Unexpectedly, sertraline and DHA had pro-inflammatory effects, with sertraline increasing IFN-alpha and IL-6 and DHA increasing IL-15, IL-1RA, IFN-alpha, and IL-6, though these changes were also associated with a decrease in NF-kB activity, suggesting distinct modes of action. Docosahexaenoic Acids 29-32 interleukin 6 Homo sapiens 104-108 16414084-0 2006 Human endothelial cells express NOD2/CARD15 and increase IL-6 secretion in response to muramyl dipeptide. Acetylmuramyl-Alanyl-Isoglutamine 87-104 interleukin 6 Homo sapiens 57-61 16414084-7 2006 Functional responses were assessed by measuring IL-6 release from endothelial cells treated with muramyl dipeptide (MDP), synthetic lipopeptide (Pam3CSK4) and lipopolysaccharide (LPS). Acetylmuramyl-Alanyl-Isoglutamine 97-114 interleukin 6 Homo sapiens 48-52 25035127-7 2014 H2S ratio was positively correlated with St. George"s Respiratory Questionnaire score, sputum neutrophils and IL-6 and IL-8 levels in sputum and serum (p<0.01) but inversely correlated with sputum macrophages (%), FEV1%predicted and FEV1/FVC (p<0.01). Hydrogen Sulfide 0-3 interleukin 6 Homo sapiens 110-114 16414084-7 2006 Functional responses were assessed by measuring IL-6 release from endothelial cells treated with muramyl dipeptide (MDP), synthetic lipopeptide (Pam3CSK4) and lipopolysaccharide (LPS). Acetylmuramyl-Alanyl-Isoglutamine 116-119 interleukin 6 Homo sapiens 48-52 16607077-3 2006 The presence of the C allele was associated with greater absolute reduction of IL-6 levels (P=0.04) following fenofibrate treatment. Fenofibrate 110-121 interleukin 6 Homo sapiens 79-83 16607077-5 2006 A relationship between the -174 G/C IL-6 polymorphism and the anti-inflammatory action of fenofibrate reported might be useful in the optimization of the treatment regimen in patients receiving this class of drugs. Fenofibrate 90-101 interleukin 6 Homo sapiens 36-40 16204306-5 2006 Furthermore, PACAP38 inhibits myeloma cell growth directly and may also indirectly by suppressing production of the growth factor, IL-6, from bone marrow stromal cells, that is stimulated by adhesion of myeloma cells. pacap38 13-20 interleukin 6 Homo sapiens 131-135 16399110-8 2006 The preoperative administration of GM (GM group) substantially alleviated hepatic I/R injury compared with the untreated control group; postoperative serum transaminase levels were significantly decreased in association with marked suppression of IL-6 levels in blood circulation during surgery. gm 35-37 interleukin 6 Homo sapiens 247-251 16399110-8 2006 The preoperative administration of GM (GM group) substantially alleviated hepatic I/R injury compared with the untreated control group; postoperative serum transaminase levels were significantly decreased in association with marked suppression of IL-6 levels in blood circulation during surgery. gm 39-41 interleukin 6 Homo sapiens 247-251 25016365-7 2014 RESULTS: Irbesartan reduced concentrations of IL-6, IL-8, CCL2, CXCL5, OPG, OPN and CXCL16 in both atheroma and primary vascular cell culture supernatants. Irbesartan 9-19 interleukin 6 Homo sapiens 46-50 16387930-1 2006 Clarithromycin (CM) has been found to inhibit the production of the intercellular adhesion molecule (ICAM)-1 and the secretion of interleukin (IL)-6 and IL-8, which may have beneficial effects on the pathophysiological changes related to rhinovirus (RV) infection. Clarithromycin 0-14 interleukin 6 Homo sapiens 130-148 16387930-1 2006 Clarithromycin (CM) has been found to inhibit the production of the intercellular adhesion molecule (ICAM)-1 and the secretion of interleukin (IL)-6 and IL-8, which may have beneficial effects on the pathophysiological changes related to rhinovirus (RV) infection. Clarithromycin 16-18 interleukin 6 Homo sapiens 130-148 16005905-6 2005 Patients using cellulose acetate showed a chronic increase in tumor necrosis factor-alpha serum levels, while those using polysulfone showed a chronic increase in interleukin 6. polysulfone P 1700 122-133 interleukin 6 Homo sapiens 163-176 16357489-12 2006 In addition, DAAE decreased TNF-alpha and IL-6 gene expression and production in human mast cells stimulated by phorbol-12-myristate-13-acetate (PMA) plus calcium ionophore A23187. diazoacetic ester 13-17 interleukin 6 Homo sapiens 42-46 16357489-13 2006 The inhibitory effect of DAAE on the TNF-alpha and IL-6 expression was NF-kappaB dependent. diazoacetic ester 25-29 interleukin 6 Homo sapiens 51-55 16420762-12 2006 Taking 1,25(OH)2D3 and reducing the level of IL-1beta, IL-6, TNFalpha may be very important in preventing and treating HBD. Calcitriol 7-18 interleukin 6 Homo sapiens 55-59 24947163-0 2014 Terpinen-4-ol and alpha-terpineol (tea tree oil components) inhibit the production of IL-1beta, IL-6 and IL-10 on human macrophages. terpinenol-4 0-13 interleukin 6 Homo sapiens 96-100 16095891-2 2005 We evaluated the effect of an in vivo weekly iloprost treatment on TNF-alpha and IL6 monocyte production (evaluated by ELISA), on monocyte apoptosis (Annexin V/uptake of propidium iodide by flow cytometry) and on peripheral blood mononuclear cell (PBMC) TNF-alpha receptors (TNF-RI and TNF-RII) mRNA expression (RT-PCR) in 14 atherosclerotic critical limb ischemia patients. Iloprost 45-53 interleukin 6 Homo sapiens 81-84 16494031-4 2005 RESULT: Compared with the control group, the levels of EGF, TGF-alpha, IL-1beta, IL-6 and IL-8 were significantly increased by treatment with Aloe coarse polysaccharide (P < 0.05, P < 0.01) and in a dose dependent manner, and the levels of TGF-beta1 and TNF were also increased but no statistical significance. Polysaccharides 154-168 interleukin 6 Homo sapiens 81-85 24488604-3 2014 In this study, TC was found to significantly inhibit hypoxia-induced cytotoxicity as well as the release of proinflammatory cytokines, including IL-1beta, TNF-alpha, and IL-6, through activation of BV2 microglia following hypoxic exposure (1 % O2, 24 h). caryophyllene 15-17 interleukin 6 Homo sapiens 170-174 16494031-5 2005 CONCLUSION: Aloe coarse polysaccharide may promote keratinocytes to secrete EGF, TGF-alpha, IL-1beta, IL-6 and IL-8. Polysaccharides 24-38 interleukin 6 Homo sapiens 102-106 16003000-8 2005 Furthermore, in the presence of U0126 and PD-98059, selective inhibitors of MEK1/2, IL-17-induced IL-6 production was significantly attenuated. U 0126 32-37 interleukin 6 Homo sapiens 98-102 16046706-7 2005 Disrupting mitogen-activated protein kinase/Erk kinase (MEK) and protein kinase C (PKC) activity with U0126 and Bisindolylmaleimide (Bis), respectively, suppressed palmitate-induced IL-6 expression (P < 0.05), but had no effect on NF-kappaB reporter gene activity (P > 0.05). U 0126 102-107 interleukin 6 Homo sapiens 182-186 16363279-7 2005 Therapy with iloprost produced a reduction in IL-1beta, L-selectin (CD 62 L) and IL-6. Iloprost 13-21 interleukin 6 Homo sapiens 81-85 24408146-12 2014 CONCLUSIONS: ADMA increased significantly after SAH, and the increase in ADMA started after the pro-inflammatory markers (CRP and IL-6) had peaked. N,N-dimethylarginine 73-77 interleukin 6 Homo sapiens 130-134 15913932-7 2005 Increased IL-6 production was partially inhibited by treatment of iron (HIF-1 inhibitor) or pyrriolidine-dithiocarbamate (PDTC, NF-kappaB inhibitor). prolinedithiocarbamate 122-126 interleukin 6 Homo sapiens 10-14 15985720-3 2005 The aim of our study was to assess the effect of fenofibrate, a commonly used hypolipidemic drug, on the release of interleukin 1beta (IL-1beta), interleukin 6 (IL-6) and monocyte chemoattractant protein 1 (MCP-1) by monocytes from patients with combined hyperlipidemia. Fenofibrate 49-60 interleukin 6 Homo sapiens 146-159 15985720-3 2005 The aim of our study was to assess the effect of fenofibrate, a commonly used hypolipidemic drug, on the release of interleukin 1beta (IL-1beta), interleukin 6 (IL-6) and monocyte chemoattractant protein 1 (MCP-1) by monocytes from patients with combined hyperlipidemia. Fenofibrate 49-60 interleukin 6 Homo sapiens 161-165 24990982-10 2014 Treatment with luzindole, a melatonin-receptor antagonist, reversed melatonin-stimulated ASIC3 expression and IL-6 production. luzindole 15-24 interleukin 6 Homo sapiens 110-114 15985720-10 2005 Thirty-day fenofibrate treatment decreased the release of IL-1beta by 43% (143.9 +/- 6.5 vs. 86.2 +/- 5.9 pg/ml), of IL-6 by 22% (8212 +/- 285 vs. 6330 +/- 234 pg/ml), and of MCP-1 by 29% (19.6 +/- 0.9 vs. 14.0 +/- 0.8 ng/ml). Fenofibrate 11-22 interleukin 6 Homo sapiens 117-121 15886721-11 2005 In all, 12 weeks of risperidone treatment significantly decreased elevated cortisol and improved negative symptoms, but produced similar effects on IL-2 and IL-6 as well as on positive symptoms compared to haloperidol. Risperidone 20-31 interleukin 6 Homo sapiens 157-161 16000871-0 2005 15-Deoxy-delta12,14-PGJ2 inhibits IL-6-induced Stat3 phosphorylation in lymphocytes. 15-deoxy-delta12 0-16 interleukin 6 Homo sapiens 34-38 25237633-0 2014 Acute Effect of Intravenous Administration of Magnesium Sulfate on Serum Levels of Interleukin-6 and Tumor Necrosis Factor-alpha in Patients Undergoing Elective Coronary Bypass Graft With Cardiopulmonary Bypass. Magnesium Sulfate 46-63 interleukin 6 Homo sapiens 83-96 15613495-3 2005 Stretch-induced IKK activation and IL-6 secretion were inhibited by application of alpha(5)beta(1) integrin-inhibitory peptide (GRGDNP), phosphatidylinositol 3-kinase inhibitor (LY-294002), phospholipase C-gamma inhibitor (U-73122), or protein kinase C inhibitor (H7). 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 223-230 interleukin 6 Homo sapiens 35-39 16021860-12 2005 IL-6 was positively correlated with BDR (r = 0.53; p < 0.04). bis-2,4-dinitrobenzenesulfonyl rhodamine 36-39 interleukin 6 Homo sapiens 0-4 16021860-14 2005 IL-6 was positively related to the BDR. bis-2,4-dinitrobenzenesulfonyl rhodamine 35-38 interleukin 6 Homo sapiens 0-4 25237633-5 2014 This study aimed to assess the effect of an IV MgSO4 infusion during elective CABG (with CBP) on the blood levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha). Magnesium Sulfate 47-52 interleukin 6 Homo sapiens 117-130 15304377-2 2004 Because 1) IL-6 mRNA expression in contracting skeletal muscle is enhanced by low muscle glycogen content, and 2) IL-6 increases lipolysis and oxidation of fatty acids, we hypothesized that regular exercise training, associated with increased levels of resting muscle glycogen and enhanced capacity to oxidize fatty acids, would lead to a less-pronounced increase of skeletal muscle IL-6 mRNA in response to acute exercise. Glycogen 102-110 interleukin 6 Homo sapiens 24-28 25237633-5 2014 This study aimed to assess the effect of an IV MgSO4 infusion during elective CABG (with CBP) on the blood levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha). Magnesium Sulfate 47-52 interleukin 6 Homo sapiens 132-136 25073269-12 2014 The serum level of IL-6 in the DM group was significantly lower than that in the control group at 3 and 24 hours after operation (P < 0.05), and than that in the mannitol group at 3, 24, and 48 hours after operation (P < 0.05). Mannitol 165-173 interleukin 6 Homo sapiens 19-23 15496611-6 2004 IL-1 beta, IL-6, IL-8 and TNF-alpha were significantly associated with lactate/choline in the DGN (p = 0.03, 0.02, 0.03, and 0.01 respectively), but not in the WS (all p > 0.1). Choline 79-86 interleukin 6 Homo sapiens 11-15 15514570-7 2004 Elevation of pro-inflammatory cytokines, such as tumor necrosis factor-alpha and interleukin-6, induced by oxaliplatin, may represent the relevant causal links involved in the cascade of events which have led to the immune-mediated demyelination in the peripheral nervous system in this patient. Oxaliplatin 107-118 interleukin 6 Homo sapiens 81-94 15557085-10 2005 Expression of the intercellular adhesion molecule-1 (ICAM-1) and production of IL-6, both important molecules in lung inflammation, was downregulated in EC treated with Syk small interfering RNA or Syk inhibitor piceatannol. 3,3',4,5'-tetrahydroxystilbene 212-223 interleukin 6 Homo sapiens 79-83 15652280-5 2005 When CYSST (1mg/ml) was added, the production of tumor necrosis factor-alpha, interleukin (IL)-6, and IL-8 was significantly inhibited about 37, 33.6, and 48%, respectively on phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated HMC-1 cells. cysst 5-10 interleukin 6 Homo sapiens 78-96 24576880-6 2014 The cell types tested, except HSF, are able to convert inactive 25-hydroxyvitamin D3 (25[OH]D3) into active 1,25-hydroxyvitamin D3 (1,25[OH]2D3). 1,25-hydroxyvitamin d3 108-130 interleukin 6 Homo sapiens 30-33 15652990-8 2005 Activation of mGluR3 with DCG-IV (but not of mGluR5 with DHPG) enhanced, in the presence of IL-1beta, the release of IL-6 in a dose dependent manner in astrocytes cultured under conditions (+EGF) in which the mGluR expression is known to be upregulated. dcg 26-29 interleukin 6 Homo sapiens 117-121 15567770-4 2004 RESULT: In patients treated with risperidone, the levels of serum IL-6 and IL-2 after 4 weeks, TNFalpha after 8 weeks, and IL-18 after 6 months were all significantly lowered in comparison with the pretreatment levels (P<0.01 or 0.05). Risperidone 33-44 interleukin 6 Homo sapiens 66-70 15567770-12 2004 CONCLUSION: Clozapine and risperidone have similar immunosuppression actions and may affect serum IL-6 levels in patients with paranoid schizophrenia, in the psychopathology of which the cytokines play their roles of various importance. Risperidone 26-37 interleukin 6 Homo sapiens 98-102 15345683-0 2004 Altering dietary nutrient intake that reduces glycogen content leads to phosphorylation of nuclear p38 MAP kinase in human skeletal muscle: association with IL-6 gene transcription during contraction. Glycogen 46-54 interleukin 6 Homo sapiens 157-161 24576880-6 2014 The cell types tested, except HSF, are able to convert inactive 25-hydroxyvitamin D3 (25[OH]D3) into active 1,25-hydroxyvitamin D3 (1,25[OH]2D3). methyl 5-methyl-3-(1,2-oxazol-5-yl)-1H-pyrazole-4-carboxylate 140-143 interleukin 6 Homo sapiens 30-33 15527794-8 2004 HaCaTs secreted interleukin-6 in response to AM, which was significantly attenuated by the NF-kappaB inhibitor SN-50. SN-50 111-116 interleukin 6 Homo sapiens 16-29 24370115-2 2014 The AuNP-graphene-silica sol-gel film was prepared in situ and modified on the ITO electrode, providing a stable network for the immobilization of antibody and exhibiting a dynamic working range of 1-40 pg/mL with a low detection limit of 0.3 pg/mL IL-6 (at 3s). Graphite 9-17 interleukin 6 Homo sapiens 249-253 24631985-8 2014 Neopterin IL-6 and IL-8 levels significantly increased first at the fourth hour after the surgery. Neopterin 0-9 interleukin 6 Homo sapiens 10-14 15378516-9 2004 Furthermore, lovastatin is able to suppress microglial tumor necrosis factor-alpha, interleukin (IL)-beta1 and IL-6 production promoted either by IFN-gamma or by Abeta peptide challenge in the presence of CD40 cross-linking. Lovastatin 13-23 interleukin 6 Homo sapiens 111-115 15591791-0 2004 Vanadate stimulates monocytic differentiation activity of IL-6 by enhancing actin filament polymerization in HL-60 cells. Vanadates 0-8 interleukin 6 Homo sapiens 58-62 15591791-4 2004 In the presence of vanadate (10 microM), a PTP inhibitor, IL-6 induced pronounced G0/G1 cell cycle arrest; this effect was associated with CD14+ monocytic differentiation as well as F-actin filament polymerization. Vanadates 19-27 interleukin 6 Homo sapiens 58-62 15591791-5 2004 Furthermore, vanadate potentiated IL-6-signaling pathway by increasing the tyrosine phosphorylated levels of STAT3 (Tyr705), and Lyn. Vanadates 13-21 interleukin 6 Homo sapiens 34-38 15591791-7 2004 Vanadate also cooperated with IL-6 to form a protein complex containing Lyn and an actin-associated protein, AFAP110. Vanadates 0-8 interleukin 6 Homo sapiens 30-34 15591791-9 2004 In conclusion, inhibition of PTP by vanadate promotes hematopoietic differentiation activity of IL-6 through modulating multiple signalings, particularly actin filament polymerization. Vanadates 36-44 interleukin 6 Homo sapiens 96-100 15345332-4 2004 U-73122, a phospholipase C (PLC) inhibitor, suppressed BK-induced IL-6 and PGE(2) synthesis in SaM-1 cells. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 0-7 interleukin 6 Homo sapiens 66-70 24296978-2 2014 Culturing LNCaP cells in androgen-depleted (AD) medium increased the levels of IL-6 and survivin, and treatment of the cells in AD medium with a combination of atorvastatin and celecoxib strongly inhibited the increase in IL-6 and survivin which is one of the downstream targets of the IL-6 signaling pathway. Celecoxib 177-186 interleukin 6 Homo sapiens 79-83 15533212-9 2004 The exposure of quiescent BMF to arecoline resulted in the elevation of IL-6 mRNA expression in a dose-dependent manner (P < 0.05). BMF 26-29 interleukin 6 Homo sapiens 72-76 24296978-2 2014 Culturing LNCaP cells in androgen-depleted (AD) medium increased the levels of IL-6 and survivin, and treatment of the cells in AD medium with a combination of atorvastatin and celecoxib strongly inhibited the increase in IL-6 and survivin which is one of the downstream targets of the IL-6 signaling pathway. Celecoxib 177-186 interleukin 6 Homo sapiens 222-226 15316561-0 2004 Abrogation of IL-6-mediated JAK signalling by the cyclopentenone prostaglandin 15d-PGJ(2) in oral squamous carcinoma cells. prostaglandin 15d-pgj 65-86 interleukin 6 Homo sapiens 14-18 24296978-2 2014 Culturing LNCaP cells in androgen-depleted (AD) medium increased the levels of IL-6 and survivin, and treatment of the cells in AD medium with a combination of atorvastatin and celecoxib strongly inhibited the increase in IL-6 and survivin which is one of the downstream targets of the IL-6 signaling pathway. Celecoxib 177-186 interleukin 6 Homo sapiens 222-226 15474068-10 2004 The NF-kappaB inhibitor (TPCK) and MAPK inhibitor (U0126) blocked the TNF-alpha-induced IL-6 expression. U 0126 51-56 interleukin 6 Homo sapiens 88-92 24296978-3 2014 Addition of recombinant IL-6 partially abrogated the combined effect of atorvastatin and celecoxib on apoptosis in LNCaP cells cultured in AD medium. Celecoxib 89-98 interleukin 6 Homo sapiens 24-28 15474071-2 2004 DESIGN: The effects of IL-1alpha, IL-1 receptor antagonist (IL-1RA), C2-ceramide, and C6-ceramide on the production of IL-6, IL-8, and M-CSF by ESC. N-acetylsphingosine 69-80 interleukin 6 Homo sapiens 119-123 24296978-6 2014 Our results indicate that decreases in IL-6 and survivin levels by atorvastatin and celecoxib administration are associated with increased apoptosis in LNCaP cells treated with this drug combination. Celecoxib 84-93 interleukin 6 Homo sapiens 39-43 15169741-14 2004 IL-6 was significantly less in the PGE1 group at the end of the operation and 2 h after the operation. Alprostadil 35-39 interleukin 6 Homo sapiens 0-4 24296978-7 2014 Our in vivo studies indicate that the inhibitory effect of a combination of atorvastatin and celecoxib on the progression of androgen-dependent LNCaP xenograft tumors to androgen independence is associated with inhibition of the increase in IL-6 and survivin that occurs when androgen-dependent LNCaP prostate tumors become androgen-independent. Celecoxib 93-102 interleukin 6 Homo sapiens 241-245 24392463-11 2014 Correlation between serum TNF-a and IL6 levels with healthy donors were statistically significant in 1h (0.004), 2h (0.001), 24h (0.001) and 48h (0.001 and 0.001) postoperatively, respectively. 48H 141-144 interleukin 6 Homo sapiens 36-39 15169741-15 2004 CONCLUSIONS: Intraoperative PGE1 reduced IL-6 production in patients undergoing oesophagectomy and oxygenation was better in the postoperative period. Alprostadil 28-32 interleukin 6 Homo sapiens 41-45 15249454-15 2004 IL-6-mediated systemic inflammatory cascades may be involved in the regulation of peripheral vascular tone after PTE. pte 113-116 interleukin 6 Homo sapiens 0-4 15332711-3 2004 Secretion of IL-1beta and TNF-a were significantly inhibited (P<0.002) whereas secretion of IL-6 and IL-10 were significantly increased (P<0.003) by rifampicin treated mononuclear cells. Rifampin 155-165 interleukin 6 Homo sapiens 95-99 15258595-3 2004 Dendrimer glucosamine inhibited Toll-like receptor 4-mediated lipopolysaccharide induced synthesis of pro-inflammatory chemokines (MIP-1 alpha, MIP-1 beta, IL-8) and cytokines (TNF-alpha, IL-1 beta, IL-6) from human dendritic cells and macrophages but allowed upregulation of the costimulatory molecules CD25, CD80, CD83 and CD86. Glucosamine 10-21 interleukin 6 Homo sapiens 199-203 23855381-13 2014 We found a correlation between sP-selectin and IL-6 (rho=0.57, p=0.0004), TPO and IL-6 (rho=0.46, p=0.001) as well as sP-selectin and TPO (rho=0.36, p=0.043), and sP-selectin and PDGF (rho=0.36, p=0.03). sp-selectin 31-42 interleukin 6 Homo sapiens 47-51 15274277-3 2004 In this study, we tested the effects of calcitriol (1alpha,25-dihydroxy-vitamin-D3) and the bisphosphonate pamidronate on titanium-particle- and TNF-alpha-induced release of interleukin-6 and suppression of osteoblast-specific gene expressions in bone-marrow-derived stromal cells with an osteoblastic phenotype. Calcitriol 40-50 interleukin 6 Homo sapiens 174-187 15274277-3 2004 In this study, we tested the effects of calcitriol (1alpha,25-dihydroxy-vitamin-D3) and the bisphosphonate pamidronate on titanium-particle- and TNF-alpha-induced release of interleukin-6 and suppression of osteoblast-specific gene expressions in bone-marrow-derived stromal cells with an osteoblastic phenotype. Calcitriol 52-82 interleukin 6 Homo sapiens 174-187 15196211-4 2004 In response to zymosan and flagellin, pathogen-associated molecular patterns (PAMP) that are recognized by TLR2 and TLR5 respectively, ECC-1 cells secreted significantly more IL-8, MCP-1 and IL-6 than in response to other TLR agonists. Zymosan 15-22 interleukin 6 Homo sapiens 191-195 15532722-8 2004 Both the fever and the increased levels of IL-1beta, IL-6, and TNF-alpha in supernatant fluids obtained from the SEA-stimulated PBMC were decreased by incubating SEA-PBMC with either PDTC, Pyri, NAC, or Cur. pyrithione 189-193 interleukin 6 Homo sapiens 53-57 24754180-5 2014 Compared to the human leukemia NOD/SCID mouse model group with the treatments of APS, Ara-c and APS + Ara-c, We found that severe liver damage and pathological changes of the liver were able to alleviate: First, the number of white blood cells in the peripheral blood was significantly lower and with less transplanted K562 leukemia cells; Second, liver function damage was alleviated as liver function tests showed that alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBiL) were significantly reduced, while the albumin (Alb) was notably increased; Third, liver antioxidant ability was improved as the activities of the antioxidant enzymes glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were significantly increased, and the contents of GSH and malonaldehyde (MDA) were decreased significantly in the liver; Fourth, the inflammation of the liver was relieved as the level of IL-1beta and IL-6, the inflammatory cytokines, were decreased significantly in the liver. Cytarabine 102-107 interleukin 6 Homo sapiens 943-947 15059966-10 2004 At POST, however, IL-6 mRNA appeared predominantly in type 2 fibers, which also had higher glycogen content (P<0.05). Glycogen 91-99 interleukin 6 Homo sapiens 18-22 24141626-7 2013 Patients with increased IL-6 and IL-2R had a significantly higher risk of early relapse and death, a finding that remained significant even after IPS-based risk stratification. IPS 146-149 interleukin 6 Homo sapiens 24-28 15294041-5 2004 The IL-6 gene is rapidly activated during exercise, and the activation of this gene is further enhanced when muscle glycogen content is low. Glycogen 116-124 interleukin 6 Homo sapiens 4-8 15059966-5 2004 Total fluorescence (PRE vs. POST) and glycogen-dependent fluorescence (LOW vs. HIGH) of IL-6 protein were quantitated using Metamorph software. Glycogen 38-46 interleukin 6 Homo sapiens 88-92 15059966-8 2004 At POST, IL-6 protein was greater (P<0.05) in HIGH compared with LOW glycogen fibers, which coincided with type 2 fibers. Glycogen 72-80 interleukin 6 Homo sapiens 9-13 24080355-4 2013 Moreover, BbV was able to stimulate neutrophil release of proinflammatory mediators such as IL-8 and IL-6 as well as PGE2 and NETs liberation. BENZYL 2-ACETAMIDO-2-DEOXY-ALPHA-D-GLUCOPYRANOSIDE 10-13 interleukin 6 Homo sapiens 101-105 15059919-2 2004 Previously, we have reported that the pleiotropic cytokine, interleukin (IL)-6, inhibited dihydrotestosterone-mediated expression of prostate-specific antigen in LNCaP cells (Jia et al., Mol Can Res 2003;1:385-92). Dihydrotestosterone 90-109 interleukin 6 Homo sapiens 60-78 14608461-3 2004 Glycogen deficiency is associated with increased expression of local cytokines (interleukin-6, IL-6), decreased expression of glucose transporters, increased cortisol and decreased insulin secretion and beta-adrenergic stimulation. Glycogen 0-8 interleukin 6 Homo sapiens 80-93 15033490-6 2004 Either adiponectin or inhibition of ERK1/2 with U0126 diminished the induction of IL6 by LPS (P<0.05), but the combination of adiponectin and the inhibitor did not further reduce IL6 production. U 0126 48-53 interleukin 6 Homo sapiens 82-85 24324713-4 2013 Icaritin inhibited both constitutive and IL-6-induced phospho-STAT3 (STAT3(Y705)) and reduced the level of STAT3-regulated proteins Bcl-xL, Mcl-1, Survivin, and CyclinD1 in a dose-dependent manner. icaritin 0-8 interleukin 6 Homo sapiens 41-45 15034930-0 2004 Superinduction of IL-6 by cycloheximide is associated with mRNA stabilization and sustained activation of p38 map kinase and NF-kappaB in cultured caco-2 cells. Cycloheximide 26-39 interleukin 6 Homo sapiens 18-22 15034930-6 2004 Treatment of Caco-2 cells with cycloheximide (10 microg/ml) increased IL-6 mRNA and protein levels in IL-1beta-treated cells and this was associated with increased mRNA stabilization. Cycloheximide 31-44 interleukin 6 Homo sapiens 70-74 15034930-9 2004 Our results suggest that superinduction of IL-6 by cycloheximide in enterocytes results from both increased mRNA stabilization and upregulated transcriptional activity mediated by prolonged activation of the p38 MAP kinase and NF-kappaB. Cycloheximide 51-64 interleukin 6 Homo sapiens 43-47 14608461-3 2004 Glycogen deficiency is associated with increased expression of local cytokines (interleukin-6, IL-6), decreased expression of glucose transporters, increased cortisol and decreased insulin secretion and beta-adrenergic stimulation. Glycogen 0-8 interleukin 6 Homo sapiens 95-99 14717786-0 2004 The effects of selective cytokine inhibitory drugs (CC-10004 and CC-1088) on VEGF and IL-6 expression and apoptosis in myeloma and endothelial cell co-cultures. CC-1088 65-72 interleukin 6 Homo sapiens 86-90 24245570-6 2013 In vitro, incubation with increasing concentrations of Fe(III)-citrate-induced inflammation in pre-adipocyte cultures as witnessed by increased IL-6 secretion at 30 mum Fe(III)-citrate vs. control (500 +- 98 pg/mL vs. 194 +- 31 pg/mL, P = 0 03). fe(iii) citrate 55-70 interleukin 6 Homo sapiens 144-148 14996410-4 2004 imipramine and venlafaxine (at the higher concentration), 5-HTP (at lower and higher concentrations) and a combination of 5-HTP and fluoxetine (both at the lower concentration) increased the production of IL-6; (2). Venlafaxine Hydrochloride 15-26 interleukin 6 Homo sapiens 205-209 15307384-8 2004 The results suggest, that in patients following THA with the elevated level of IL-6, the inflammatory process was present. Tacrine 48-51 interleukin 6 Homo sapiens 79-83 15312472-0 2004 [Changes in plasma levels of LPS, TNFalpha and IL-6 in burn patients with severe infection treated with Imipenem or Cefoperazone]. Cefoperazone 116-128 interleukin 6 Homo sapiens 47-51 15312472-1 2004 OBJECTIVE: To observe the changes in plasma levels of lipopolysaccharide (LPS), tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) in burn patients with severe infection treated with Imipenem or Cefoperazone. Cefoperazone 209-221 interleukin 6 Homo sapiens 139-143 15078004-0 2004 Effect of multiple doses of clarithromycin and amoxicillin on IL-6, IFNgamma and IL-10 plasma levels in patients with community acquired pneumonia. Clarithromycin 28-42 interleukin 6 Homo sapiens 62-66 15078004-7 2004 Clarithromycin significantly decreased plasma levels of IL-6 and significantly increased those of IFNgamma and IL-10 at the 3rd and 7th day in comparison to basal levels. Clarithromycin 0-14 interleukin 6 Homo sapiens 56-60 24245570-6 2013 In vitro, incubation with increasing concentrations of Fe(III)-citrate-induced inflammation in pre-adipocyte cultures as witnessed by increased IL-6 secretion at 30 mum Fe(III)-citrate vs. control (500 +- 98 pg/mL vs. 194 +- 31 pg/mL, P = 0 03). fe(iii) citrate 169-184 interleukin 6 Homo sapiens 144-148 23349129-10 2013 GNF351 inhibited the recruitment of AHR to the promoters of IL1B and IL6 confirming occupancy of AHR at these promoters is required for enhanced inflammatory signalling. N-(2-(3H-indol-3-yl)ethyl)-9-isopropyl-2-(5-methyl-3-pyridyl)purin-6-amine 0-6 interleukin 6 Homo sapiens 69-72 14979481-4 2004 IL-6-induced proliferation in CD45+ U266 cells was inhibited by vanadate, a potent protein tyrosine phosphatase inhibitor. Vanadates 64-72 interleukin 6 Homo sapiens 0-4 14532843-6 2003 Subsequently the dose dependent effect of dihydrotestosterone (DHT) on BCG induced IL-6 expression and NF-kappaB signaling was evaluated. Dihydrotestosterone 42-61 interleukin 6 Homo sapiens 83-87 15633585-2 2004 Since muscle metabolism in elderly subjects relies on glycogen more than younger subjects, it is possible that aging is associated with an altered production of muscle-derived IL-6 during exercise. Glycogen 54-62 interleukin 6 Homo sapiens 176-180 12937023-3 2003 IL-6 was released from the leg already after 10 min of exercise in the glycogen-depleted state, whereas no significant release was observed at any time in the loaded state. Glycogen 71-79 interleukin 6 Homo sapiens 0-4 14532843-6 2003 Subsequently the dose dependent effect of dihydrotestosterone (DHT) on BCG induced IL-6 expression and NF-kappaB signaling was evaluated. Dihydrotestosterone 63-66 interleukin 6 Homo sapiens 83-87 23613464-0 2013 Mediatory role of interleukin-6 in alpha smooth muscle actin induction and myofibroblast formation around silicone tissue expander. Silicones 106-114 interleukin 6 Homo sapiens 18-31 14532843-9 2003 DHT suppressed BCG induced, NF-kappaB mediated signaling and IL-6 expression in a dose dependent manner. Dihydrotestosterone 0-3 interleukin 6 Homo sapiens 61-65 14532843-10 2003 DHT decreased mRNA levels of IL-6, expression of the full-length IL-6 promoter construct and expression of an NF-kappaB specific reporter construct in response to BCG relative to controls. Dihydrotestosterone 0-3 interleukin 6 Homo sapiens 29-33 14532843-10 2003 DHT decreased mRNA levels of IL-6, expression of the full-length IL-6 promoter construct and expression of an NF-kappaB specific reporter construct in response to BCG relative to controls. Dihydrotestosterone 0-3 interleukin 6 Homo sapiens 65-69 14532843-12 2003 CONCLUSIONS: DHT down-regulates NF-kappaB mediated IL-6 expression by human TCC lines in response to BCG. Dihydrotestosterone 13-16 interleukin 6 Homo sapiens 51-55 12937023-7 2003 After 60 min of exercise in the glycogen-depleted state, individual values of alpha2-AMPK activity correlated significantly (r = 0.87, P < 0.006) with individual values of IL-6 release as well as with average IL-6 release over the entire 60 min (r = 0.86, P < 0.006). Glycogen 32-40 interleukin 6 Homo sapiens 175-179 12937023-7 2003 After 60 min of exercise in the glycogen-depleted state, individual values of alpha2-AMPK activity correlated significantly (r = 0.87, P < 0.006) with individual values of IL-6 release as well as with average IL-6 release over the entire 60 min (r = 0.86, P < 0.006). Glycogen 32-40 interleukin 6 Homo sapiens 212-216 12937023-9 2003 Alternatively, both AMPK and IL-6 are independent sensors of a low muscle glycogen concentration during exercise. Glycogen 74-82 interleukin 6 Homo sapiens 29-33 24035274-8 2013 The PGI2 analogue enhanced the activation of STAT3 in response to IL-6, whereas it decreased STAT5 activation in response to IL-2. Epoprostenol 4-8 interleukin 6 Homo sapiens 66-70 14636306-0 2003 Inhibition of intracellular tumour necrosis factor (TNF)-alpha and interleukin (IL)-6 production in human monocytes by iloprost. Iloprost 119-127 interleukin 6 Homo sapiens 67-85 14636306-1 2003 BACKGROUND: To investigate the effects of iloprost as a stable prostacyclin analogue on intracellular expression of IL-6 and TNF-alpha of lipopolysaccharide (LPS)-stimulated human monocytes in a whole blood system assessed by flow cytometry. Iloprost 42-50 interleukin 6 Homo sapiens 116-120 14636306-4 2003 RESULTS: Our investigations showed, for the first time, that iloprost (0.1 nm up to 100 nm) caused a dose-dependent inhibitory effect of IL-6 production in human monocytes stimulated with LPS (10 ng mL(-1)), which was even more obvious in monocytes stimulated with lower concentrated LPS (0.2 ng mL(-1)). Iloprost 61-69 interleukin 6 Homo sapiens 137-141 14636306-6 2003 CONCLUSIONS: Apart from the vasodilatory and antithrombotic effects, iloprost may also down-regulate the intracellular expression of IL-6 and TNF-alpha in human monocytes. Iloprost 69-77 interleukin 6 Homo sapiens 133-137 14559242-6 2003 Telithromycin selectively inhibited the IL-6 and IL-8 production from Stx-stimulated (but not LPS-stimulated) monocytes. telithromycin 0-13 interleukin 6 Homo sapiens 40-44 12691958-6 2003 The stimulatory effect of UTP, but not ATP, in A549 cells is attenuated by preincubation with interleukin-1beta and interleukin-6, but not tumor necrosis factor-alpha. Uridine Triphosphate 26-29 interleukin 6 Homo sapiens 116-129 23817417-7 2013 Combined celecoxib and TNF-alpha blockade more effectively suppressed the proinflammatory loop than did single treatment, as shown by lower IL-6, IL-8, matrix metalloproteinase-1 and matrix metalloproteinase-3 production. Celecoxib 9-18 interleukin 6 Homo sapiens 140-144 19180800-4 2003 Purple bamboo salt (1 mg/mL) inhibited phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 secretion, by 67.04% +/- 0.08%, 68.01% +/- 1.85%, and 69.48% +/- 0.54%, respectively. bamboo salt 0-18 interleukin 6 Homo sapiens 180-184 14669830-2 2003 In addition, intravenous or oral pulse calcitriol treatment suppresses interleukin 6 (IL6) and interleukin1beta (IL1beta) in hemodialysis patients. Calcitriol 39-49 interleukin 6 Homo sapiens 71-84 14669830-2 2003 In addition, intravenous or oral pulse calcitriol treatment suppresses interleukin 6 (IL6) and interleukin1beta (IL1beta) in hemodialysis patients. Calcitriol 39-49 interleukin 6 Homo sapiens 86-89 23538947-11 2013 Pretreatment of cells with specific Rho-kinase inhibitor (Y27632) and Rac1 inhibitor (NSC23766) drastically inhibited S1P-induced IL-6 secretion. Y 27632 58-64 interleukin 6 Homo sapiens 130-134 12832117-6 2003 In mice immunized with X4064(pCH1A+pYL3E) significantly higher sera IgG and IgA titers for lipopolysaccharide (LPS) were found compared to mice immunized with X4064(pCH1A) and a hIL-6-negative control strain. Sodium orotate 23-28 interleukin 6 Homo sapiens 178-183 12794182-2 2003 During exercise, muscle IL-6 mRNA levels and plasma IL-6 levels are increased and further augmented when intramuscular glycogen levels are low. Glycogen 119-127 interleukin 6 Homo sapiens 24-28 12810609-8 2003 Statistically significant correlations between IL-6 and both 8-iso-PGF2alpha (r=0.63, P<0.001) and 11-dehydro-TXB2 (r=0.51, P<0.01) were observed. 11-dehydro-thromboxane B2 102-117 interleukin 6 Homo sapiens 47-51 23602849-5 2013 Functional characterization of sbIL-6P was performed by cloning sbIL-6P into a luciferase expression vector and by transfecting it into L6 muscle cells, a mammalian cell line shown previously to express IL-6 in response to pro-inflammatory stimuli. sbil-6p 64-71 interleukin 6 Homo sapiens 33-37 12858333-0 2003 1,25-Dihydroxyvitamin D3 inhibits ultraviolet B-induced apoptosis, Jun kinase activation, and interleukin-6 production in primary human keratinocytes. Calcitriol 0-24 interleukin 6 Homo sapiens 94-107 12962573-5 2003 GA-specific TCLs produce dominantly IL-2, IL-4, IFN-gamma and IL-10, but low levels of IL-6. Glatiramer Acetate 0-2 interleukin 6 Homo sapiens 87-91 23361365-10 2013 Taken together, our results demonstrate that DHA and EPA are able to reduce IL-6-induced CRP expression in HepG2 cells via an inhibition of STAT3 activation. Docosahexaenoic Acids 45-48 interleukin 6 Homo sapiens 76-80 12885386-7 2003 Treatment with alendronate increased LPS-induced secretion of IL-1beta, IL-6 and TNF-alpha from RAW 264 macrophages 2.4-, 1.4- and 1.8-fold, respectively. Alendronate 15-26 interleukin 6 Homo sapiens 72-76 23504656-5 2013 IL-6 was elevated in the NL and OL groups compared with the NH group, as well as the OL group compared with the OH group. ol 32-34 interleukin 6 Homo sapiens 0-4 12782111-9 2003 BEAS-2B cells exposed to carboxyl-SPM responded with significant increases in [Ca(2+)](i), and IL-6 release relative to uncharged SPM or diamino-SPM. carboxyl-spm 25-37 interleukin 6 Homo sapiens 95-99 12782111-11 2003 Although both diamino and carboxyl-SPM groups stimulated increases in IL-6 transcript, only the more electronegatively charged carboxyl-SPM stimulated mRNA-VR1 receptor. carboxyl-spm 26-38 interleukin 6 Homo sapiens 70-74 12792728-9 2003 In order to investigate the direct relationship between butyrate and IL-6, n-sodium butyrate (n-BT) was added to the NPC cells in an in vitro study, and marked increase of IL-6 expression was detected in n-BT-treated cells. n-bt 94-98 interleukin 6 Homo sapiens 172-176 12792728-9 2003 In order to investigate the direct relationship between butyrate and IL-6, n-sodium butyrate (n-BT) was added to the NPC cells in an in vitro study, and marked increase of IL-6 expression was detected in n-BT-treated cells. n-bt 204-208 interleukin 6 Homo sapiens 172-176 12727366-6 2003 Prolonged incubation of both serum-opsonized and -unopsonized zymosan particles with HUVEC induced increased secretion of the proinflammatory cytokines IL-6 and IL-8 to the cell culture supernatants, but had no effect on production of oxygen radicals. Zymosan 62-69 interleukin 6 Homo sapiens 152-156 23628149-7 2013 Compared with E group, EC group showed renal tissue IL-1beta, IL-6, TNF-alpha and NF-KB expression decreased significantly, respectively (p < 0.05). ec 23-25 interleukin 6 Homo sapiens 62-66 12505790-3 2003 Treatment with the p38 inhibitor SB-203580, the MEK1 and MEK2 inhibitor U-0126, or the translational inhibitor cycloheximide inhibited the induction of C/EBP beta and IL-6 by IFN-gamma, whereas the MEK1 inhibitor PD-98059 or the tyrosine kinase inhibitor genistein had no effect. U 0126 72-78 interleukin 6 Homo sapiens 167-171 12753408-0 2003 Regulation of 1-alpha, 25-dihydroxyvitamin D3 on interleukin-6 and interleukin-8 induced by sulfur mustard (HD) on human skin cells. Calcitriol 14-45 interleukin 6 Homo sapiens 49-62 12938820-18 2003 Upon short exposure to a single GDP, MCs react with enhanced cytotoxic damage and a proinflammatory response, evidenced by increased VCAM-1 expression and elevated production of IL-6 and IL-8. mcs 37-40 interleukin 6 Homo sapiens 178-182 23637950-4 2013 PRINCIPAL FINDINGS: Serum-differentiated macrophages stimulated with beta-glucans showed a low production of TNFalpha and IL-1beta, a high production of IL-6 and IL-23, and a delayed induction of cyclooxygenase-2 and PGE2 biosynthesis that resembled the responses elicited by crystals and those produced when phagosomal degradation of the phagocytic cargo increases ligand access to intracellular pattern recognition receptors. beta-Glucans 69-81 interleukin 6 Homo sapiens 153-157 12653788-7 2003 The correlation analysis revealed a significant correlation of IL-6 and/or IL-8 to age, total fructose, immunoglobulin G (IgG) concentration and leucocyte count. Fructose 94-102 interleukin 6 Homo sapiens 63-67 12653788-8 2003 The significant correlation of IL-6 and fructose levels indicates that also the seminal vesicles take part in the production of seminal IL-6. Fructose 40-48 interleukin 6 Homo sapiens 136-140 12505790-3 2003 Treatment with the p38 inhibitor SB-203580, the MEK1 and MEK2 inhibitor U-0126, or the translational inhibitor cycloheximide inhibited the induction of C/EBP beta and IL-6 by IFN-gamma, whereas the MEK1 inhibitor PD-98059 or the tyrosine kinase inhibitor genistein had no effect. Cycloheximide 111-124 interleukin 6 Homo sapiens 167-171 12736434-7 2003 Recombinant hIL-6 treatment to DMBA-treated IL-6-null mice suppressed the occurrence of the skin damage, indicating. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 31-35 interleukin 6 Homo sapiens 12-17 23235712-9 2013 In conclusion, based on a meta-analysis of nine randomized controlled trials, telmisartan therapy is likely effective in reducing IL-6 and TNF-alpha levels. Telmisartan 78-89 interleukin 6 Homo sapiens 130-134 23660101-11 2013 In both groups, IL-6 values and APACHEII score showed a positive correlation (r=0.930, P=0.003; r=0.964, P=0.000), and also between IL-6 values and CTSI (r=0.915, P=0.000; r=0.921, P=0.005) at 48 hours. ctsi 148-152 interleukin 6 Homo sapiens 16-20 12522661-3 2003 The aim of this study was to evaluate the effect of etidronate (10-4-10-9 M) and alendronate (10-7-10-12 M) on the production of IL-6 and IL-11 using human osteoblast cultures. Alendronate 81-92 interleukin 6 Homo sapiens 129-133 12595852-6 2003 PGE1 administration for 7 days resulted in a significant decrease in the MCP-1 level, from 263.8 +/- 52.8 to 196.1 +/- 25.5 pg/mL (P =.02), whereas levels of IL-6, hs-CRP, and ET-1 and the activity of vWF were not affected. Alprostadil 0-4 interleukin 6 Homo sapiens 158-162 12672196-6 2003 Normal ESR, CRP, and IL-6 levels persisted after the suspension of infliximab and prednisone during the followup period, paralleling the clinical remission. Prednisone 82-92 interleukin 6 Homo sapiens 21-25 12719662-4 2003 Microglial production of nitrite, interleukin-6 and tumor necrosis factor-alpha was induced by Abeta40, but not Abeta42. Nitrites 25-32 interleukin 6 Homo sapiens 34-79 23497105-11 2013 Treatment with 10 mug/ml MeOHGCM6 extract during differentiation of U937 cells significantly inhibited TNF-alpha response level and TNF-alpha and IL-6 gene expression. meohgcm6 25-33 interleukin 6 Homo sapiens 146-150 12690457-2 2003 The transcription rate for IL-6 in muscle nuclei isolated from muscle biopsies during exercise is very high and is enhanced further when muscle glycogen content is low. Glycogen 144-152 interleukin 6 Homo sapiens 27-31 14506330-0 2003 Preoperative administration of rebamipide significantly lowers body temperature and circulating interleukin-6 in gastric cancer patients after gastrectomy. rebamipide 31-41 interleukin 6 Homo sapiens 96-109 23397947-3 2013 In this study we investigated whether nicotinamide (NCT), the amide form of vitamin B3, might have a protective function in reducing the expression of interleukin (IL)-1beta, IL-6, IL-8, IL-10, monocyte chemoattractant protein (MCP)-1 and tumour necrosis factor (TNF)-alpha in UV-irradiated keratinocytes. Amides 45-50 interleukin 6 Homo sapiens 175-179 14506330-14 2003 CONCLUSION: Preoperative administration of rebamipide significantly decreased postoperative body temperatures and circulating IL-6 in gastric cancer patients after gastrectomy to levels similar to those of patients with LADG. rebamipide 43-53 interleukin 6 Homo sapiens 126-130 12544908-6 2003 RESULTS: Increases in IL-8, IL-6, and IL-10 were greater in patients resuscitated with PRBCs. prbcs 87-92 interleukin 6 Homo sapiens 28-32 12651911-8 2003 Substantial qualitative and quantitative differences in PSA expression and AR occupancy of the PSA enhancer were observed when DHT-induced and ligand-independent activations of the AR were compared; forskolin stimulated PSA mRNA and protein expression, whereas IL-6 inhibited both DHT- and forskolin-stimulated expression. Dihydrotestosterone 127-130 interleukin 6 Homo sapiens 261-265 12574335-6 2003 Analysis of supernatants revealed that rNef treatment induced the release of macrophage inflammatory proteins 1alpha and 1beta, IL-1beta, IL-6, and TNF-alpha. rnef 39-43 interleukin 6 Homo sapiens 138-142 12384353-3 2002 Azithromycin decreased the tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6 production from Stx-treated human peripheral mononuclear cells or monocytes to a greater extent than did clarithromycin. Azithromycin 0-12 interleukin 6 Homo sapiens 102-106 23398903-14 2013 Combination of Aspirin and Docosahexaenoic Acid showed augmentation in total Glutathione production during TLR-7 stimulation as well as a reduction in IL-6, TNF-alpha and Nitric Oxide. Docosahexaenoic Acids 27-47 interleukin 6 Homo sapiens 151-155 12234873-1 2002 The antibiotic telithromycin was examined for its effect on secretion of interleukin-1alpha (IL-1alpha), IL-1beta, IL-6, IL-10, and tumor necrosis factor alpha (TNF-alpha) by lipopolysaccharide (LPS)-stimulated monocytes of eight human donors. telithromycin 15-28 interleukin 6 Homo sapiens 115-119 12623273-5 2003 When azithromycin was added to infected cultures of FSC at 0 or 48 h after infection, the level of IL-6 production was very low. Azithromycin 5-17 interleukin 6 Homo sapiens 99-103 23374147-8 2013 CONCLUSIONS: The increase in the Th1 response in the TIVA-TCI group and the reduction in Tregs in the BAL group seem to balance the immunosuppressive effect induced by IL-6. tci 58-61 interleukin 6 Homo sapiens 168-172 12483712-4 2003 PMMA had a negative effect on osteoblasts, whereas PMMA+alpha-TCP enhanced production of ALP, PICP, OC and TGFbeta-1, and reduced IL-6 levels. calcium phosphate 56-65 interleukin 6 Homo sapiens 130-134 23682327-0 2013 Comparison between preoperative administration of methylprednisolone with its administration before and during congenital heart surgery on serum levels of IL-6 and IL-10. Methylprednisolone 50-68 interleukin 6 Homo sapiens 155-159 12452837-0 2002 Inflammatory cytokine (interleukin 6 and tumour necrosis factor alpha) release in a human whole blood system in response to Streptococcus pneumoniae serotype 14 and its capsular polysaccharide. Polysaccharides 178-192 interleukin 6 Homo sapiens 23-69 12195834-5 2002 IL-6 was higher in all three patients groups but only in the BILD group it was significantly higher than the control group (P < 0.05). bild 61-65 interleukin 6 Homo sapiens 0-4 12101275-7 2002 Inhibition was specific for IL-6, as induction of STAT activation by IFN-gamma, IFN-alpha, and vanadate was not inhibited. Vanadates 95-103 interleukin 6 Homo sapiens 28-32 23682327-2 2013 OBJECTIVES: This study was performed to compare effectiveness of preoperative and intraoperative methylprednisolone (MP) to preoperative methylprednisolone alone in post bypass inflammatory (IL-6) and anti-inflammatory (IL-10) factors. Methylprednisolone 97-115 interleukin 6 Homo sapiens 191-195 12453891-8 2002 Finally, a 1.5-h preincubation of primary hepatocytes with IL-6 inhibits insulin-induced glycogen synthesis by 75%. Glycogen 89-97 interleukin 6 Homo sapiens 59-63 23682327-2 2013 OBJECTIVES: This study was performed to compare effectiveness of preoperative and intraoperative methylprednisolone (MP) to preoperative methylprednisolone alone in post bypass inflammatory (IL-6) and anti-inflammatory (IL-10) factors. Methylprednisolone 117-119 interleukin 6 Homo sapiens 191-195 23013513-0 2013 Effects of simvastatin and ezetimibe on interleukin-6 and high-sensitivity C-reactive protein. Ezetimibe 27-36 interleukin 6 Homo sapiens 40-53 22884251-7 2013 Furthermore, a significant increase in the number of CD4(+) T cells, a significant decrease in the percentage of Tregs in the CD4(+) T-cell population, and a significant decrease in the serum IL-6 and IL-10 levels 24 hours after PMX-F therapy were observed in septic shock survivors compared with nonsurvivors. pmx-f 229-234 interleukin 6 Homo sapiens 192-196 12436367-9 2002 Circulating nitrate levels also correlated to the serum interleukin-6 levels. Nitrates 12-19 interleukin 6 Homo sapiens 56-69 12411982-6 2002 We found a striking inverse relationship between both TNF-alpha and IL-6 plasma concentrations and the activity of CYP2C19; metabolism of caffeine (CYP1A2) also had a negative association with IL-6 plasma concentrations. Caffeine 138-146 interleukin 6 Homo sapiens 193-197 12119487-0 2002 Effect of mizoribine on IL-6 release by peripheral blood mononuclear cells. mizoribine 10-20 interleukin 6 Homo sapiens 24-28 12119487-2 2002 This study was conducted to investigate whether the efficacy of MZB on IgAN is exerted by suppression of interleukin-6 (IL-6) release. mizoribine 64-67 interleukin 6 Homo sapiens 105-118 12119487-2 2002 This study was conducted to investigate whether the efficacy of MZB on IgAN is exerted by suppression of interleukin-6 (IL-6) release. mizoribine 64-67 interleukin 6 Homo sapiens 120-124 12119487-8 2002 10 mg/ml of MZB suppressed the release of IL-6 in both IgAN patients (median decrease in IL-6 release 39.3%) and controls (median 43.2%), with statistical significance (p < 0.05 and p < 0.01, respectively). mizoribine 12-15 interleukin 6 Homo sapiens 42-46 12119487-8 2002 10 mg/ml of MZB suppressed the release of IL-6 in both IgAN patients (median decrease in IL-6 release 39.3%) and controls (median 43.2%), with statistical significance (p < 0.05 and p < 0.01, respectively). mizoribine 12-15 interleukin 6 Homo sapiens 89-93 23032719-4 2013 We found that evodiamine suppressed both constitutive and interleukin-6 (IL-6)-induced activation of STAT3 tyrosine 705 (Tyr(705)) effectively. evodiamine 14-24 interleukin 6 Homo sapiens 58-71 11891214-6 2002 Selective MAP kinase kinase (MEK)1/2 inhibitors, PD98059 and U0126, inhibited, in a dose-dependent manner, ML-1-induced expression of IL-6 and IL-8. U 0126 61-66 interleukin 6 Homo sapiens 134-138 12225373-5 2002 Stimulation with zymosan and LPS readily induced interleukin (IL)-6 and IL-8 cytokine production in the placenta cultures, whereas TLR2 and TLR4 mRNA and protein expression remained at the same high level as in unstimulated explants. Zymosan 17-24 interleukin 6 Homo sapiens 49-67 23032719-4 2013 We found that evodiamine suppressed both constitutive and interleukin-6 (IL-6)-induced activation of STAT3 tyrosine 705 (Tyr(705)) effectively. evodiamine 14-24 interleukin 6 Homo sapiens 73-77 12099927-6 2002 Interestingly, we observed a significant negative correlation between IL-6 and nitrite/nitrate levels in the CSF in the total MS group. Nitrites 79-86 interleukin 6 Homo sapiens 70-74 11741878-0 2002 MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels. Gold 12-14 interleukin 6 Homo sapiens 85-98 23032719-6 2013 Interestingly, treatment of cells with sodium pervanadate abrogated the inhibition of evodiamine on IL-6-induced STAT3 (Tyr(705)) activation indicating the involvement of protein tyrosine phosphatases. evodiamine 86-96 interleukin 6 Homo sapiens 100-104 11805217-8 2002 Blockading PDE5 (4-[[3",4"-(methylenedioxy)benzyl] amino]-6-methoxyquinazoline) showed a high potency in reducing IL-6 production, but in a manner similar to the inhibition of PDE4, exhibited a biphasic effect on TNF-alpha biosynthesis. 4-[[3",4"-(methylenedioxy)benzyl] amino]-6-methoxyquinazoline 17-78 interleukin 6 Homo sapiens 114-118 12099927-6 2002 Interestingly, we observed a significant negative correlation between IL-6 and nitrite/nitrate levels in the CSF in the total MS group. Nitrates 87-94 interleukin 6 Homo sapiens 70-74 12137744-5 2002 The inhibitors SB203580, PD98059, SN50, cycloheximide and D-ribofuranosylbenzimidazole each reduced the basal and TNFalpha-stimulated secretion of IL-1beta and also reduced IL-6 secretion with the exception of SN50. Cycloheximide 40-53 interleukin 6 Homo sapiens 173-177 23032719-8 2013 Moreover, inhibition of SHP-1 gene by small interference RNA abolished the ability of evodiamine to inhibit IL-6-induced STAT3 (Tyr(705)) activation. evodiamine 86-96 interleukin 6 Homo sapiens 108-112 12067409-4 2002 MG-132 increased the expression of IL-6 mRNA and protein;and this effect was abolished by the pretreatment of the cells with U0126, an inhibitor of MAP or ERK kinases (MEK 1/2). U 0126 125-130 interleukin 6 Homo sapiens 35-39 12137803-3 2002 In this investigation, we showed that RU486, already proved to be an active anti-glucocorticoid and anti-progesterone agent, blocked the inhibition of tumor necrosis factor (TNF)-alpha-stimulated interleukin-6 (IL-6) production by the PPARalpha activator fenofibrate in human umbilical vein ECs. Fenofibrate 255-266 interleukin 6 Homo sapiens 196-209 11755467-0 2002 Interferon-alpha 2b and vesnarinone influence levels of tumor necrosis factor-alpha, apoptosis, or interleukin 6 in ESKOL, a hairy cell leukemic cell line. vesnarinone 24-35 interleukin 6 Homo sapiens 99-112 22424556-8 2013 Under hypoxia, betaine also reduced the mRNA level of the pro-inflammatory markers IL-6 and TNF-alpha. Betaine 15-22 interleukin 6 Homo sapiens 83-87 11899364-6 2002 Serum IL-6 levels correlated with sVEGF levels and with the calculated VEGF/pl. svegf 34-39 interleukin 6 Homo sapiens 6-10 12030972-8 2002 The results indicated that dihydrotestosterone simultaneously downregulates the production of IL-6 and upregulates the cell proliferation. Dihydrotestosterone 27-46 interleukin 6 Homo sapiens 94-98 23744413-4 2013 Numerous studies report that treatment with clozapine (doses 37.5-600 mg) or olanzapine (doses 10-25 mg) or the use of these drugs in polytherapy cause pyrexia between 37.8-40.6 C. Additionally, levels of proinflammatory interleukins such as IL-6, IL-1,TNF-alpha were increased. Clozapine 44-53 interleukin 6 Homo sapiens 243-247 11746782-10 2002 Moreover, addition of IL-6 to three-dimensional brain cell cultures treated with 3 x 10(-7) M of MeHgCl prevented the decrease in immunostaining of the neuronal markers MAP-2 and neurofilament-M. IL-6 administered to three-dimensional cultures in the absence of MeHgCl caused astrogliosis, as indicated by increased GFAP immunoreactivity. methylmercuric chloride 262-268 interleukin 6 Homo sapiens 196-200 23326479-9 2013 Additionally, DON significantly induced the expression of genes involved in the differentiation of Th17 cells (STAT3, IL-17A, IL-6, IL-1beta) at the expenses of the pathway of regulatory T cells (Treg) (FoxP3, RALDH1). deoxynivalenol 14-17 interleukin 6 Homo sapiens 126-130 11814313-7 2001 The magnitude of IL-6 inhibition was also greater for DHEA (group mean, treated/control of 62%) compared to DHT (81%) and E(2)(76%). Dihydrotestosterone 108-111 interleukin 6 Homo sapiens 17-21 11814313-8 2001 In cultures from subjects receiving ERT, DHEA and DHT suppressed IL-6 in some, whereas E(2)did not suppress IL-6 secretion. Dihydrotestosterone 50-53 interleukin 6 Homo sapiens 65-69 11687509-0 2001 Transcriptional activation of the IL-6 gene in human contracting skeletal muscle: influence of muscle glycogen content. Glycogen 102-110 interleukin 6 Homo sapiens 34-38 11840366-6 2002 The passage to CD membrane was followed by a progressive new increase in the IL-6 PBMC release (332.3 +/- 30.7 after 3 months, and 351.2 +/- 35.8 pg/mL after 6 months, respectively) that, however, remained significantly (P < 0.05) lower than CU. cellulose diacetate 15-17 interleukin 6 Homo sapiens 77-81 22985912-5 2013 The secretion of proinflammatory products was strongly stimulated by sequential incubation of EC with iodixanol and TNFalpha (p<0.00001 for all tested molecules, namely TNFalpha, IL-8, sVCAM-1, MCP-1, and IL-6). iodixanol 102-111 interleukin 6 Homo sapiens 208-212 11818704-2 2002 In this prospective randomized study, we aimed to compare the effect of oral and intravenous (IV) pulse calcitriol on serum levels of IL-1 beta and IL-6. Calcitriol 104-114 interleukin 6 Homo sapiens 148-152 11818704-8 2002 Oral and IV calcitriol caused a significant fall in IL-1 beta (p = 0.02 and p = 0.03, respectively) and IL-6 levels (p = 0.02 and p < 0.001, respectively) at the 6th month of treatment. Calcitriol 12-22 interleukin 6 Homo sapiens 104-108 11799073-4 2002 GSA increased expression of early response genes, c-fos and c-jun, and inflammatory genes, monocyte chemoattractant peptide (MCP-1), and interleukin (IL)-6. gsa 0-3 interleukin 6 Homo sapiens 137-155 11799073-6 2002 One of signaling pathways by which GSA activates VSMCs appears to be via nuclear factor kappaB activation, leading to induction of MCP-1 and IL-6 gene expression, comparable to the effects of lipopolysaccharide, TNF-alphaa, and IL-1alphab. gsa 35-38 interleukin 6 Homo sapiens 141-145 11687509-4 2001 Increases in plasma IL-6 during exercise were significantly higher (P<0.05) in the low-glycogen (16-fold) trial verses the control (10-fold) trial. Glycogen 90-98 interleukin 6 Homo sapiens 20-24 11687509-5 2001 Transcriptional activation of the IL-6 gene in skeletal muscle was also higher in the low-glycogen trial; it increased by about 40-fold after 90 min of exercise and about 60-fold after 180 min of exercise. Glycogen 90-98 interleukin 6 Homo sapiens 34-38 11687509-6 2001 Muscle IL-6 mRNA followed a similar but delayed pattern, increasing by more than 100-fold in the low-glycogen trial and by about 30-fold in the control trial. Glycogen 101-109 interleukin 6 Homo sapiens 7-11 11687509-7 2001 These data demonstrate that exercise activates transcription of the IL-6 gene in working skeletal muscle, a response that is dramatically enhanced when glycogen levels are low. Glycogen 152-160 interleukin 6 Homo sapiens 68-72 11799073-9 2002 Incubation of VSMCs with the antioxidant N-acetylcysteine suppressed GSA-elicited mRNA induction of MCP-1 and IL-6. gsa 69-72 interleukin 6 Homo sapiens 110-114 11687509-8 2001 These findings also support the hypothesis that IL-6 may be produced by contracting myofibers when glycogen levels become critically low as a means of signaling the liver to increase glucose production. Glycogen 99-107 interleukin 6 Homo sapiens 48-52 23062767-12 2012 CONCLUSIONS: A high simvastatin dose or the combination of a low-dose simvastatin with ezetimibe reduce to a similar extent TLR2, TLR4 membrane expression and LPS-induced IL-6 and IL-1beta production in monocytes of hypercholesterolemic patients. Ezetimibe 87-96 interleukin 6 Homo sapiens 171-175 11766169-6 2001 Four other 8-ketotrichothecenes, fusarenon X, nivalenol, 3-acetyl DON, and 15-acetyl DON, were also capable of upregulating or suppressing TNF-alpha, IL-6, and IL-8 production at concentrations similar to that of DON. nivalenol 46-55 interleukin 6 Homo sapiens 150-154 22933321-8 2012 In addition, the increases in the levels of IL-6 or TGFbeta1 in conditioned media from endothelial cells following phagocytosis of NTD were significantly reduced by nifedipine. Nifedipine 165-175 interleukin 6 Homo sapiens 44-48 11814313-2 2001 We tested the hypothesis that IL-6 secretion by human marrow cells and a line of marrow stromal cells (KM101) is inhibited by dehydroepiandrosterone (DHEA), dihydrotestosterone (DHT) and 17beta-oestradiol (E(2)). Dihydrotestosterone 157-176 interleukin 6 Homo sapiens 30-34 11814313-2 2001 We tested the hypothesis that IL-6 secretion by human marrow cells and a line of marrow stromal cells (KM101) is inhibited by dehydroepiandrosterone (DHEA), dihydrotestosterone (DHT) and 17beta-oestradiol (E(2)). Dihydrotestosterone 178-181 interleukin 6 Homo sapiens 30-34 11786660-8 2001 After 3 months of CAM treatment, serum levels of IL-6 significantly decreased. Clarithromycin 18-21 interleukin 6 Homo sapiens 49-53 11531018-4 2001 Co-administration of PepG (10 microg/mL) or muramyl dipeptide (MDP, 1 microg/mL) with LPS (10 ng/mL) caused significantly elevated values of TNF-alpha and IL-6 in the blood that could not be obtained by the sum of the values obtained by each stimulant alone, or by 3-fold higher doses of either bacterial component alone. Acetylmuramyl-Alanyl-Isoglutamine 44-61 interleukin 6 Homo sapiens 155-159 11531018-4 2001 Co-administration of PepG (10 microg/mL) or muramyl dipeptide (MDP, 1 microg/mL) with LPS (10 ng/mL) caused significantly elevated values of TNF-alpha and IL-6 in the blood that could not be obtained by the sum of the values obtained by each stimulant alone, or by 3-fold higher doses of either bacterial component alone. Acetylmuramyl-Alanyl-Isoglutamine 63-66 interleukin 6 Homo sapiens 155-159 11459775-3 2001 We therefore examined the effects of the PPARalpha activator fenofibrate and the GR activator dexamethasone on TNFalpha-stimulated expression of IL-6 and vascular cell adhesion molecule-1 in vascular endothelial cells. Fenofibrate 61-72 interleukin 6 Homo sapiens 145-149 11786660-11 2001 Furthermore, CAM-treated patients whose serum IL-6 levels were decreased after 3 months of treatment survived longer: there was a statistically significant correlation between the decrease in serum IL-6 and survival time. Clarithromycin 13-16 interleukin 6 Homo sapiens 46-50 11786660-11 2001 Furthermore, CAM-treated patients whose serum IL-6 levels were decreased after 3 months of treatment survived longer: there was a statistically significant correlation between the decrease in serum IL-6 and survival time. Clarithromycin 13-16 interleukin 6 Homo sapiens 198-202 11459775-4 2001 Both fenofibrate and dexamethasone reduced TNFalpha-induced IL-6 production in human vascular endothelial cells, but only fenofibrate reduced TNFalpha-stimulated vascular cell adhesion molecule-1 expression in these cells. Fenofibrate 5-16 interleukin 6 Homo sapiens 60-64 22646055-0 2012 Relationship between interleukin-6 and ammonia in patients with minimal hepatic encephalopathy due to liver cirrhosis. Ammonia 39-46 interleukin 6 Homo sapiens 21-34 11459775-6 2001 EMSA demonstrated that both fenofibrate and dexamethasone reduced nuclear factor-kappaB binding to its recognition site on the IL-6 promoter, but only fenofibrate reduced such binding to the vascular cell adhesion molecule-1 promoter. Fenofibrate 28-39 interleukin 6 Homo sapiens 127-131 11267862-7 2001 LiCl, a potent inhibitor of Glycogen Synthase Kinase 3beta (GSK3beta) activity, abrogated the IL-6-induced inhibition of wild-type beta-catenin. Lithium Chloride 0-4 interleukin 6 Homo sapiens 94-98 22646055-8 2012 Moreover, there was a significant correlation between circulating levels of IL-6 and those of ammonia in patients with MHE (r = 0.61, P < 0.05), and a positive additive interaction was found between IL-6 and ammonia on the presence of MHE, with a significant synergy index of 1.51 (95% confidence interval = 1.12-3.46). Ammonia 94-101 interleukin 6 Homo sapiens 76-80 11331038-6 2001 Cycloheximide (CHX) alone increased both gp130 and IL-6 transcripts in the BMSC. Cycloheximide 0-13 interleukin 6 Homo sapiens 51-55 11295678-2 2001 In vitro studies have shown that desloratadine inhibits the release or generation of multiple inflammatory mediators, including IL-4, IL-6, IL-8, IL-13, PGD(2), leukotriene C(4), tryptase, histamine, and the TNF-alpha-induced chemokine RANTES. desloratadine 33-46 interleukin 6 Homo sapiens 134-138 11331038-6 2001 Cycloheximide (CHX) alone increased both gp130 and IL-6 transcripts in the BMSC. Cycloheximide 15-18 interleukin 6 Homo sapiens 51-55 22646055-8 2012 Moreover, there was a significant correlation between circulating levels of IL-6 and those of ammonia in patients with MHE (r = 0.61, P < 0.05), and a positive additive interaction was found between IL-6 and ammonia on the presence of MHE, with a significant synergy index of 1.51 (95% confidence interval = 1.12-3.46). Ammonia 94-101 interleukin 6 Homo sapiens 202-206 22646055-8 2012 Moreover, there was a significant correlation between circulating levels of IL-6 and those of ammonia in patients with MHE (r = 0.61, P < 0.05), and a positive additive interaction was found between IL-6 and ammonia on the presence of MHE, with a significant synergy index of 1.51 (95% confidence interval = 1.12-3.46). Ammonia 211-218 interleukin 6 Homo sapiens 76-80 22646055-9 2012 CONCLUSION: The present study demonstrates a significant correlation and a positive additive interaction between IL-6 and ammonia in cirrhotic patients with MHE, suggesting that IL-6 may have a potential synergistic relationship with ammonia in the induction of MHE. Ammonia 124-131 interleukin 6 Homo sapiens 180-184 24387017-0 2001 Mizoribine, an inhibitor of inosine monophosphate dehydrogenase, inhibits interleukin-6 production by freshly prepared rheumatoid synovial cells. mizoribine 0-10 interleukin 6 Homo sapiens 74-87 11283429-7 2001 IL-6 was elevated at 15 min and 2 h after AN-TS (P < 0.01 to SMT and Co-Day) but only slightly 2 h after SMT (P < 0.01 to Co-Day). S-Methylisothiourea hemisulfate 64-67 interleukin 6 Homo sapiens 0-4 22646055-9 2012 CONCLUSION: The present study demonstrates a significant correlation and a positive additive interaction between IL-6 and ammonia in cirrhotic patients with MHE, suggesting that IL-6 may have a potential synergistic relationship with ammonia in the induction of MHE. Ammonia 236-243 interleukin 6 Homo sapiens 115-119 24387017-3 2001 To further characterize the mechanism of the antirheumatic action of this drug, we examined the effect of mizoribine on the production of interleukin (IL)-6, a major inflammatory cytokine in rheumatoid synovia, by freshly prepared rheumatoid synovial cells (RSC). mizoribine 106-116 interleukin 6 Homo sapiens 138-156 24387017-4 2001 Mizoribine (1.25-5 mug/ml) was able to inhibit the spontaneous production of IL-6 by fresh RSC in a dose-response fashion. mizoribine 0-10 interleukin 6 Homo sapiens 77-81 22646055-9 2012 CONCLUSION: The present study demonstrates a significant correlation and a positive additive interaction between IL-6 and ammonia in cirrhotic patients with MHE, suggesting that IL-6 may have a potential synergistic relationship with ammonia in the induction of MHE. Ammonia 236-243 interleukin 6 Homo sapiens 180-184 24387017-6 2001 In addition, mizoribine inhibited the enhanced production of IL-6 by the IL-1alpha and/or tumor necrosis factor alpha-stimulated RSC. mizoribine 13-23 interleukin 6 Homo sapiens 61-65 22738124-5 2012 The black currant extract and cyanidin-3-O-glucoside also inhibited the LPS-induced secretion of interleukin-6 by human macrophages. cyanidin-3-o-glucoside 30-52 interleukin 6 Homo sapiens 97-110 24387017-9 2001 These data suggest that mizoribine inhibits IL-6 production by fresh RSC, possibly owing to the depletion of intracellular GMP, and that this inhibitory effect of the drug on rheumatoid synovial cells may be related to its efficacy in RA. mizoribine 24-34 interleukin 6 Homo sapiens 44-48 11256129-8 2001 Whereas under BIA, the concentrations of IL-6 were found to be significantly elevated during the course of the study, the release of the soluble IL-2R alpha and the production of IL-1RA were reduced in this patient group in comparison to the TIVA group. bia 14-17 interleukin 6 Homo sapiens 41-45 11037761-6 2000 None or weakly toxic concentrations of Ni and Co chloride induced IL-6 and IL-8 release by a factor of 5-10 compared to controls. co chloride 46-57 interleukin 6 Homo sapiens 66-70 23132229-8 2012 Exogenous H(2)S inhibited the TNF-alpha-mediated upregulation of NO, IL-6 and IL-8 in a dose-dependent manner. Hydrogen Sulfide 10-15 interleukin 6 Homo sapiens 69-73 11007863-0 2000 Changing relationships between serum IL-1, IL-6, and TNF-alpha and dynamic tests of parathyroid gland function in haemodialysis patients with severe hyperparathyroidism in response to calcitriol therapy. Calcitriol 184-194 interleukin 6 Homo sapiens 43-47 11022123-8 2000 Moreover, there were highly significant correlations between nitrate and IL-6 serum levels (p < 0.05), nitrate and sTNFr-I (p < 0.05), nitrate and sTNFr-II (p < 0.05), and between IL-6 and IL-10 (p < 0.05), respectively. Nitrates 61-68 interleukin 6 Homo sapiens 73-77 11022123-8 2000 Moreover, there were highly significant correlations between nitrate and IL-6 serum levels (p < 0.05), nitrate and sTNFr-I (p < 0.05), nitrate and sTNFr-II (p < 0.05), and between IL-6 and IL-10 (p < 0.05), respectively. Nitrates 61-68 interleukin 6 Homo sapiens 189-193 11053984-0 2000 Oxaliplatin-induced fever and release of IL-6. Oxaliplatin 0-11 interleukin 6 Homo sapiens 41-45 11053984-10 2000 CONCLUSION: Our data suggest a clear- cut correlation between fever, the release of IL-6 and oxaliplatin administration. Oxaliplatin 93-104 interleukin 6 Homo sapiens 84-88 22688551-9 2012 Vildagliptin treatment was associated with a stronger decrease in nitrotyrosine (P < 0.01), IL-6 (P < 0.05), and IL-18 (P < 0.05) than sitagliptin treatment. Vildagliptin 0-12 interleukin 6 Homo sapiens 95-99 11053984-11 2000 Whether IL-6 release is directly triggered by the application of oxaliplatin or is a bystander phenomenon, however, remains unclear at the moment. Oxaliplatin 65-76 interleukin 6 Homo sapiens 8-12 10873159-7 2000 Release of IL-6 elicited by TNF-alpha was significantly inhibited by dexamethasone, cycloheximide, and nordihydroguaiaretic acid (NDGA). Cycloheximide 84-97 interleukin 6 Homo sapiens 11-15 10816606-7 2000 Inhibition of the de novo synthesis of NF-IL-6 by cycloheximide or an antisense oligonucleotide reduced the enhancement of NF-IL-6 binding to the CAAT box and inhibited stimulation of IL-6 transcription by forskolin. Cycloheximide 50-63 interleukin 6 Homo sapiens 42-46 10924340-4 2000 In parallel, IL-6 decreases both rifampicin- and phenobarbital-mediated induction of CYP2B6, CYP2C8, CYP2C9, and CYP3A4. Rifampin 33-43 interleukin 6 Homo sapiens 13-17 22677362-3 2012 As in humans, cantharidin (12.5 mug/ear) generated macrophage-inflammatory protein (MIP)-2, monocyte chemoattractant protein (MCP)-1, keratinocyte-derived chemokine (KC), interleukin (IL)-6, IL-1beta, and myeloperoxidase (MPO) production, as well as neutrophil accumulation in mouse ear tissue. Cantharidin 14-25 interleukin 6 Homo sapiens 171-189 10921541-13 2000 CONCLUSIONS: PGE1 suppressed the production of IL-6 and IL-8 but not IL-10, IL-1ra, sTNF RI, or sTNF RII. Alprostadil 13-17 interleukin 6 Homo sapiens 47-51 10679281-3 2000 The PolyG-MDP was found to trigger the secretion of higher levels of interleukin-6, interleukin-1alpha, TNF-alpha, and nitric oxide in comparison to free MDP. Acetylmuramyl-Alanyl-Isoglutamine 10-13 interleukin 6 Homo sapiens 69-82 10774110-2 2000 The levels of IL-6 were measured in follicular fluid of 15 patients undergone to in vitro fertilization and embryo transfer and correlated with the values of seric estradiol and progesterone. seric estradiol 158-173 interleukin 6 Homo sapiens 14-18 10839761-4 2000 Azithromycin reduced a global rank sum score of 4 inflammatory markers (C-reactive protein [CRP], interleukin [IL]-1, IL-6, tumor necrosis factor-alpha; P=.011) and a global rank sum change score (+/-SD) (from 535+/-201 to 587+/-190; P=.027) at 6 (but not 3) months. Azithromycin 0-12 interleukin 6 Homo sapiens 118-122 22561121-10 2012 LPS induced the mRNA expressions of IL-1beta, TNF-alpha, IL-6, CCL2, iNOS, and COX-2, and although zaprinast significantly induced the expressions of all except IL-6 and iNOS, these inductions were far less than those induced by LPS. zaprinast 99-108 interleukin 6 Homo sapiens 161-165 10853849-6 2000 There were significant (p<0.05) pre- to post-exposure increases in total cells, neutrophils, IL-6 and IL-8 in both the azithromycin and placebo arms. Azithromycin 122-134 interleukin 6 Homo sapiens 96-100 10631097-0 2000 Low-density lipoprotein-induced expression of interleukin-6, a marker of human mesangial cell inflammation: effects of oxidation and modulation by lovastatin. Lovastatin 147-157 interleukin 6 Homo sapiens 46-59 10631097-7 2000 Lovastatin markedly inhibited mesangial cell expression of IL-6 mRNA and reduced IL-6 secretion. Lovastatin 0-10 interleukin 6 Homo sapiens 59-63 22460770-11 2012 Asymmetric dimethylarginine was inversely correlated with organ dysfunction by Pediatric Logistic Organ Dysfunction score (r = -0.50, p = .009), interleukin-6 (r = -0.55, p = .01), and interleukin-8 (r = -0.52, p = .03) on admission. dimethylarginine 11-27 interleukin 6 Homo sapiens 145-158 10631097-7 2000 Lovastatin markedly inhibited mesangial cell expression of IL-6 mRNA and reduced IL-6 secretion. Lovastatin 0-10 interleukin 6 Homo sapiens 81-85 10623435-5 2000 Moreover, we have previously demonstrated that 5-fluorouracile (5-FU) resistant HSC require a combination of interleukin 12 (IL-12), IL-6 and SCF for the production of morphologically recognizable clonogenic elements at day 14 in semisolid medium. 5-fluorouracile 47-62 interleukin 6 Homo sapiens 133-137 10787131-5 2000 RESULTS: The Cd-B correlated closely with Cd-U, and both Cd-B and Cd-U with Cd-F, on an individual basis (n = 607), on an SS basis (n = 30) and on a regional basis (n = 7). cd-u 66-70 interleukin 6 Homo sapiens 76-80 22743898-1 2012 BACKGROUND: Several studies have reported adverse immunological effects of silicone due to their ability to induce proinflammatory molecules, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). Silicones 75-83 interleukin 6 Homo sapiens 194-207 10705937-3 2000 RESULTS: Production of TNF-alpha, IL-1alpha, IL-1beta and IL-6 by PBMC and TNF-alpha by PBM were significantly lower in the patients with PD as compared to the control groups. phytobacteriomycin 66-69 interleukin 6 Homo sapiens 58-62 10692240-2 2000 Spontaneous and PHA-stimulated IL-6 release inversely correlated with height velocity, bone age, IGF-I, and IGFBP-3 SDS. sds 116-119 interleukin 6 Homo sapiens 31-35 10772337-1 2000 DM650, a soluble human IL-6Ralpha mutant with mutation of C277D/H280I, was previously shown to exhibit an antagonism to IL-6, which resulted in growth-inhibition of human multiple myeloma cell line AF-10 autocrining as the growth-stimulating factor. dm650 0-5 interleukin 6 Homo sapiens 23-27 10585421-5 1999 The inhibitory effect of PE on IL-6 activation of STAT3 was also abolished by the tyrosine phosphatase inhibitor sodium vanadate, indicating involvement of protein tyrosine phosphatases. Vanadates 113-128 interleukin 6 Homo sapiens 31-35 10602388-6 1999 Time-course experiments showed a NaF-induced IL-6 response at 5 h, whereas an IL-8 response was observed after 10 h. Cycloheximide treatment completely abolished the NaF-induced cytokine responses. Cycloheximide 117-130 interleukin 6 Homo sapiens 45-49 22743898-1 2012 BACKGROUND: Several studies have reported adverse immunological effects of silicone due to their ability to induce proinflammatory molecules, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). Silicones 75-83 interleukin 6 Homo sapiens 209-213 10504447-4 1999 The increase of activator protein-2 mRNA was detected at 30 min after stimulation and that of activator protein-2 protein was at 2 h. Their levels were lower than the control levels at 24 h. The interleukin-6-dependent induction of activator protein-2 mRNA was completely blocked by adding actinomycin D, whereas it was approximately 50% affected by cycloheximide. Cycloheximide 350-363 interleukin 6 Homo sapiens 195-208 22743898-10 2012 Silicone microparticles at 100 mug/ml, however, significantly induced the production and gene expression of TNF-alpha, IL-6, and IFN-gamma by peripheral blood mononuclear cells. Silicones 0-8 interleukin 6 Homo sapiens 119-123 10824456-5 2000 The amounts of drained TNF-alpha and IL-6 in the lymph peaked at 2-4 hr and 4-8 hr after zymosan administration, respectively. Zymosan 89-96 interleukin 6 Homo sapiens 37-41 22391335-0 2012 12(S)-Hydroxyheptadeca-5Z,8E,10E-trienoic acid suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity. 12(s)-hydroxyheptadeca-5z,8e,10e-trienoic acid 0-46 interleukin 6 Homo sapiens 69-73 10769429-10 2000 D-hormone preparations (alfacalcidol, calcitriol) possess immunoregulatory effects in vitro and in vivo by inhibiting the cytokines IL-1, IL-6, TNF-alpha and particularly IL-12. Calcitriol 38-48 interleukin 6 Homo sapiens 138-142 10555884-5 1999 RESULTS: A significant decrease of IL-1, IL-6, TNF-alpha, and beta2m was observed after 30 days, persisting after 90 days in the AL group, but with no significant variation in the placebo group. Alendronate 129-131 interleukin 6 Homo sapiens 41-45 10500532-0 1999 [Doxifluridine decreases serum levels of interleukin-6 in a cancer cachexia model]. doxifluridine 1-14 interleukin 6 Homo sapiens 41-54 10500532-5 1999 Oral administration of doxifluridine (5"-DFUR, 60 mg/kg or 120 mg/kg) significantly inhibited the growth of KPL-4 tumors, reduced the tissue levels of IL-6, and alleviated body weight loss. doxifluridine 23-36 interleukin 6 Homo sapiens 151-155 10500532-5 1999 Oral administration of doxifluridine (5"-DFUR, 60 mg/kg or 120 mg/kg) significantly inhibited the growth of KPL-4 tumors, reduced the tissue levels of IL-6, and alleviated body weight loss. doxifluridine 38-45 interleukin 6 Homo sapiens 151-155 10500532-8 1999 We suggest that 5"-DFUR suppresses cancer cachexia by lowering IL-6 levels in the tumor tissues and serum. doxifluridine 16-23 interleukin 6 Homo sapiens 63-67 10467171-6 1999 Actinomycin D, cycloheximide, indomethacin, and NS-398 (COX-2 inhibitor) suppressed the production of IL-6 and PGE(2). Cycloheximide 15-28 interleukin 6 Homo sapiens 102-106 10467171-8 1999 In addition, stimulation with 17-phenyl-PGE(2), a PGE receptor-1 (EP-1 receptor) agonist, led to the expression of IL-6 mRNA after pretreatment with IL-1beta. 17-phenyl-pge 30-43 interleukin 6 Homo sapiens 115-119 10226093-1 1999 BACKGROUND: Calcium channel blockers (CCB) of all subclasses: the dihydropyridines, benzothiazepines, and phenylalkylamines, at nanomolar concentrations, have been shown to up-regulate interleukin-6 (IL-6) mRNA. Dihydropyridines 66-82 interleukin 6 Homo sapiens 185-198 22366389-8 2012 CONCLUSIONS: Methylprednisolone used in preoperative period could degrade the bilirubin and IL-6 level safely and effectively after operation but does not reduce the mortality and the average hospital stay for liver sclerotic patients with normal liver function with slight side effects; it may have positive clinical effects for marginal liver patients. Methylprednisolone 13-31 interleukin 6 Homo sapiens 92-96 10226093-1 1999 BACKGROUND: Calcium channel blockers (CCB) of all subclasses: the dihydropyridines, benzothiazepines, and phenylalkylamines, at nanomolar concentrations, have been shown to up-regulate interleukin-6 (IL-6) mRNA. Dihydropyridines 66-82 interleukin 6 Homo sapiens 200-204 10226093-2 1999 We investigated the underlying molecular mechanism responsible for IL-6 induction in response to the CCB amlodipine, diltiazem, and verapamil in primary human vascular smooth muscle cells (VSMC). Diltiazem 117-126 interleukin 6 Homo sapiens 67-71 10099541-2 1999 Quantitative reconstitution of the native disulfide bonds of hIL-6 from the fully denatured E. coli extracts could be performed by glutathione-assisted oxidation in a completely denaturating condition (6M guanidinium chloride) at protein concentrations higher than 1 mg/mL, preventing aggregation of reduced hIL-6. Guanidine 205-225 interleukin 6 Homo sapiens 61-66 10523023-7 1999 Most interestingly, IL-6-producing CD4+ and CD8+ T cells could only be detected in cultures with 1alpha,25-(OH)2D3, reaching a plateau after 14 days. Calcitriol 97-114 interleukin 6 Homo sapiens 20-24 10457265-4 1999 Treatment with 5alpha-dihydrotestosterone (DHT) dose-dependently inhibited constitutive and TNF-alpha/IL-1beta-stimulated IL-6 mRNA steady-state levels in hFOB/AR-6 cells by 70-80% at 10-7 M. In addition, testosterone also suppressed TNF-alpha/IL-1beta-stimulated IL-6 mRNA levels by 57%, while the adrenal androgen dehydroepiandrosterone had no effect. Dihydrotestosterone 15-41 interleukin 6 Homo sapiens 122-126 10457265-4 1999 Treatment with 5alpha-dihydrotestosterone (DHT) dose-dependently inhibited constitutive and TNF-alpha/IL-1beta-stimulated IL-6 mRNA steady-state levels in hFOB/AR-6 cells by 70-80% at 10-7 M. In addition, testosterone also suppressed TNF-alpha/IL-1beta-stimulated IL-6 mRNA levels by 57%, while the adrenal androgen dehydroepiandrosterone had no effect. Dihydrotestosterone 15-41 interleukin 6 Homo sapiens 264-268 10457265-4 1999 Treatment with 5alpha-dihydrotestosterone (DHT) dose-dependently inhibited constitutive and TNF-alpha/IL-1beta-stimulated IL-6 mRNA steady-state levels in hFOB/AR-6 cells by 70-80% at 10-7 M. In addition, testosterone also suppressed TNF-alpha/IL-1beta-stimulated IL-6 mRNA levels by 57%, while the adrenal androgen dehydroepiandrosterone had no effect. Dihydrotestosterone 43-46 interleukin 6 Homo sapiens 122-126 10457265-4 1999 Treatment with 5alpha-dihydrotestosterone (DHT) dose-dependently inhibited constitutive and TNF-alpha/IL-1beta-stimulated IL-6 mRNA steady-state levels in hFOB/AR-6 cells by 70-80% at 10-7 M. In addition, testosterone also suppressed TNF-alpha/IL-1beta-stimulated IL-6 mRNA levels by 57%, while the adrenal androgen dehydroepiandrosterone had no effect. Dihydrotestosterone 43-46 interleukin 6 Homo sapiens 264-268 10457265-6 1999 Consistent with the Northern analyses, treatment with 5alpha-DHT, testosterone, and hydroxyflutamide also inhibited IL-6 protein production by 79%, 62%, and 71%, respectively (p < 0.001), while these agents had no effect on IL-6 soluble receptor levels. Dihydrotestosterone 54-64 interleukin 6 Homo sapiens 116-120 10457265-6 1999 Consistent with the Northern analyses, treatment with 5alpha-DHT, testosterone, and hydroxyflutamide also inhibited IL-6 protein production by 79%, 62%, and 71%, respectively (p < 0.001), while these agents had no effect on IL-6 soluble receptor levels. Dihydrotestosterone 54-64 interleukin 6 Homo sapiens 227-231 21913190-7 2012 Interleukin-6 production by MSC at physiologically low O(2) concentrations might be one of the factors mediating this effect. o(2) 55-59 interleukin 6 Homo sapiens 0-13 10449154-3 1999 We report that the endogenous CS hydrocortisone and the synthetic CS clobetasol-17-propionate strongly inhibited the production of the inflammatory mediators interleukin (IL)-12 p70, tumor necrosis factor alpha (TNF-alpha), and IL-6 by lipopolysaccharide (LPS)-stimulated monocyte-derived immature DC (iDC) in vitro. cs hydrocortisone 30-47 interleukin 6 Homo sapiens 228-232 10456614-3 1999 Oncostatin-M- and interleukin-6-induced fibrinogen release was inhibited in a dose-dependent manner by ciprofibrate and, to lesser extent, by bezafibrate, fenofibric acid and clofibric acid. ciprofibrate 103-115 interleukin 6 Homo sapiens 18-31 9808582-11 1998 Third, the use of vanadate, a potent inhibitor of protein tyrosine phosphatase (PTP), abrogated the IL-6-induced proliferation in the CD45(+) myeloma cells. Vanadates 18-26 interleukin 6 Homo sapiens 100-104 9659617-2 1998 Incubation of macrophages with cobalt chromium led to release of tumor necrosis factor-alpha (TNF-alpha) and prostaglandin E2 (PGE2), but did not lead to release of interleukin-1 beta (IL-1 beta) or interleukin 6 (IL-6). cobalt chromium 31-46 interleukin 6 Homo sapiens 199-212 9659617-2 1998 Incubation of macrophages with cobalt chromium led to release of tumor necrosis factor-alpha (TNF-alpha) and prostaglandin E2 (PGE2), but did not lead to release of interleukin-1 beta (IL-1 beta) or interleukin 6 (IL-6). cobalt chromium 31-46 interleukin 6 Homo sapiens 214-218 22340011-3 2012 For example, norzoanthamine inhibits interleukin-6, the key mediator of bone resorption in osteoporosis, providing a promising drug candidate for a disease that affects more than 10 million people over age 50 in the United States. norzoanthamine 13-27 interleukin 6 Homo sapiens 37-50 9687383-1 1998 We show that the coumeromycin antibiotic novobiocin, a potent inhibitor of ADP ribosylation, prevents lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF-alpha), interleukin-1 (IL-1), IL-6, and IL-10 secretion in human peripheral blood mononuclear cells. coumeromycin 17-29 interleukin 6 Homo sapiens 198-202 10397515-4 1999 METHODS: The effects of the androgens, T and DHT, on IL-6 production were measured in vitro in serum-free, phenol red-free medium. Dihydrotestosterone 45-48 interleukin 6 Homo sapiens 53-57 9922315-6 1999 Forskolin mimicked the stimulatory effects of these neurotransmitters on IL-6 secretion, and the protein kinase inhibitor6-22 amide abolished the actions of VIP, CGRP, and norepinephrine, but not that of human recombinant IL-1beta, on IL-6 secretion. -22 amide 122-131 interleukin 6 Homo sapiens 235-239 21848430-9 2012 However, in presence of doxycycline, inhibition of cytokines (IL-1beta and IL-6) was only observed in stimulated cells from fertile women with primary C. trachomatis infection. Doxycycline 24-35 interleukin 6 Homo sapiens 75-79 10221415-5 1999 The results with IL-6 and TNF-alpha in the clarithromycin studies were most striking. Clarithromycin 43-57 interleukin 6 Homo sapiens 17-21 9716376-7 1998 The HSF activation by proteasome inhibitors was completely blocked in the presence of the protein synthesis inhibitor cycloheximide. Cycloheximide 118-131 interleukin 6 Homo sapiens 4-7 9648083-9 1998 The concentration of IL-6 in the supernatant of stimulated monocytes was highest with Glu/Bic (1023 +/- 278 pg/ml) and Amino/Bic (776 +/- 296 pg/ml) an lowest with Glu/lac pH 5.5 (46 +/- 22 pg/ml) and Glu-poly/PBS (32 +/- 13 pg/ml). Lactose 168-171 interleukin 6 Homo sapiens 21-25 21902578-6 2012 IL-6 levels remained a significant outcome predictor also including IPI as a covariate (p = 0.006 for progression-free survival). diprotin A 68-71 interleukin 6 Homo sapiens 0-4 9655393-8 1998 In hyperlipidaemic patients, fenofibrate treatment decreases the plasma concentrations of interleukin-6, fibrinogen and C-reactive protein. Fenofibrate 29-40 interleukin 6 Homo sapiens 90-103 9581864-2 1998 In the present study, we investigated the effect of tiludronate, a bisphosphonate known to inhibit bone resorption, on the PGF2alpha- and PGE1-induced IL-6 synthesis in these cells. Alprostadil 138-142 interleukin 6 Homo sapiens 151-155 10022397-6 1999 Compared with controls (IL-6, 1.1 +/- 0.3 ng/L; IL-8, 3.2 +/- 0.8 ng/L), untreated patients with GD and TNG had elevated IL-6 (GD, 7.11 +/- 0.88 ng/L; TNG, 7.30 +/- 0.77 ng/L; P < 0.001) and IL-8 (GD, 10.3 +/- 1.23 ng/L; TNG, 9.81 +/- 1.27 ng/L; P < 0.001). Nitroglycerin 104-107 interleukin 6 Homo sapiens 24-28 9884428-7 1999 In the interleukin-6-positive patients without steroid therapy, serum creatinine increased significantly after 1 year (Deltas-Cr; 1.04 +/- 0.45 mg/dl) and creatinine clearance decreased significantly (DeltaCcr; -11.7 +/- 3.2 ml/min) compared to the interleukin-6-negative patients without steroid therapy. deltas 119-125 interleukin 6 Homo sapiens 7-20 9874511-8 1998 IL-6 completely abolished detectable expression of BMP-2 mRNA, which was also greatly reduced by IL-1beta, retinoic acid and 1,25(OH)2 vitamin D3. Calcitriol 125-145 interleukin 6 Homo sapiens 0-4 21161531-0 2012 Inhibitors of p38 and ERK1/2 MAPkinase and hydrogen sulphide block constitutive and IL-1beta-induced IL-6 and IL-8 expression in the human chondrocyte cell line C-28/I2. Hydrogen Sulfide 43-60 interleukin 6 Homo sapiens 101-105 9564285-13 1998 The removal of IL-6 and IL-8 by CVVH after initial stimulation correlates with clinical improvement, which was demonstrated by significantly improved oxygenation and hemodynamics from 2 hours after the initiation of CVVH onward. cvvh 32-36 interleukin 6 Homo sapiens 15-19 22119537-9 2012 High oxHDL did not predict all-cause mortality; however, it was significantly associated with CVD-related mortality and composite CVD events, particularly with concomitant high IL-6. oxhdl 5-10 interleukin 6 Homo sapiens 177-181 9865496-5 1998 Our present data show a correlation between the production of nitrite + nitrate (NO2- + NO3-) and that of circulating cytokines IFN and IL-6. Nitrites 62-69 interleukin 6 Homo sapiens 136-140 9865496-5 1998 Our present data show a correlation between the production of nitrite + nitrate (NO2- + NO3-) and that of circulating cytokines IFN and IL-6. Nitrates 72-79 interleukin 6 Homo sapiens 136-140 9584910-1 1998 The effect of the dentifrice ingredient triclosan (2,4,4"-trichloro-2"-hydroxyldiphenyl ether) on the production of interleukin (IL)-1beta and IL-6 was studied in human gingival fibroblasts challenged with tumor necrosis factor alpha (TNFalpha) in vitro. Triclosan 40-49 interleukin 6 Homo sapiens 143-147 22063737-8 2012 We investigated whether EJG inhibits the release of cycloxygenase (COX), 5-lipoxygenase (5-LOX), interleukin-6 (IL-6) and nuclear factor kappa B (NF-kappaB) in LPS stimulated human peripheral blood mononuclear cells (hPBMCs). ejg 24-27 interleukin 6 Homo sapiens 97-110 9475357-1 1998 Whole-cell pertussis found in diphtheria-tetanus-pertussis (DTP) vaccine can produce symptoms reminiscent of biological responses to circulating proinflammatory monokines such as IL-6, IL-1beta, and TNFalpha. dtp 60-63 interleukin 6 Homo sapiens 179-183 9722934-3 1998 In the present study we investigated whether the androgen dihydrotestosterone (DHT) affects the expression and regulation of IL-6 in gingival fibroblasts. Dihydrotestosterone 58-77 interleukin 6 Homo sapiens 125-129 9722934-3 1998 In the present study we investigated whether the androgen dihydrotestosterone (DHT) affects the expression and regulation of IL-6 in gingival fibroblasts. Dihydrotestosterone 79-82 interleukin 6 Homo sapiens 125-129 9722934-4 1998 Using a "capture" ELISA assay, it was found that increasing DHT concentrations progressively reduced IL-6 production by gingival cells from normal individuals and from patients with gingival inflammation and gingival hyperplasia. Dihydrotestosterone 60-63 interleukin 6 Homo sapiens 101-105 9722934-8 1998 Moreover, semi-quantitative RT-PCR showed that DHT acted at the level of transcription of the IL-6 gene, causing a marked reduction in the relative level of IL-6 mRNA in the gingival cells. Dihydrotestosterone 47-50 interleukin 6 Homo sapiens 94-98 22063737-9 2012 Results shows that EJG dose dependently inhibited LPS-activated COX, 5-LOX, IL-6, and NF-kappaB in hPBMCs. ejg 19-22 interleukin 6 Homo sapiens 76-80 9722934-8 1998 Moreover, semi-quantitative RT-PCR showed that DHT acted at the level of transcription of the IL-6 gene, causing a marked reduction in the relative level of IL-6 mRNA in the gingival cells. Dihydrotestosterone 47-50 interleukin 6 Homo sapiens 157-161 9506876-2 1998 Spontaneous and IL-1 + TNF-alpha stimulated IL-6 release was measured in supernatants of cultures of human osteoblastic osteosarcoma cells MG-63, pretreated for 4 hours with different doses of etidronate, clodronate or alendronate using a specific bioassay. Alendronate 219-230 interleukin 6 Homo sapiens 44-48 9506876-3 1998 Etidronate [from 10(-4) to 10(-8) M] or alendronate [from 10(-6) to 10(-11) M] inhibited in a dose-dependent manner the cytokine-induced IL-6 secretion [60+/-9.5% at 10(-5) M and 65+/-12% at 10(-7) M, respectively; p < 0.01]. Alendronate 40-51 interleukin 6 Homo sapiens 137-141 22969169-15 2012 Serum neopterin correlated with hsCRP (r = 0.285, P = 0.002), IL-6 (r = 0.212, P = 0.034), and IFN-gamma (r = 0.32, P = 0.001) but not with TNF-alpha. Neopterin 6-15 interleukin 6 Homo sapiens 62-66 9625031-6 1998 RESULTS: An interesting effect on proinflammatory monokines was observed: in this study, we demonstrate that the calcium antagonist diltiazem enhances interleukin-1beta and slightly reduces interleukin-6 production in MLC, but it has no effect on tumor necrosis factor-alpha levels. Diltiazem 132-141 interleukin 6 Homo sapiens 190-203 9850935-6 1998 PGE1 and PGE2, but not PGD2 and PGF2 alpha, led to a rapid and transient induction of astrocytic IL-6 mRNA, followed by IL-6 protein synthesis. Alprostadil 0-4 interleukin 6 Homo sapiens 97-101 9455080-0 1997 [Effects of olprinone on IL-6 and IL-10 production during and after cardiac surgery]. olprinone 12-21 interleukin 6 Homo sapiens 25-29 9850935-6 1998 PGE1 and PGE2, but not PGD2 and PGF2 alpha, led to a rapid and transient induction of astrocytic IL-6 mRNA, followed by IL-6 protein synthesis. Alprostadil 0-4 interleukin 6 Homo sapiens 120-124 22661192-8 2012 The ability of R-11 to affect interleukin- 6 (IL-6) production was determined in the whole human blood cell culture. trichlorofluoromethane 15-19 interleukin 6 Homo sapiens 30-44 9449430-3 1997 In this study we investigated at cellular level the influence of two anti-inflammatory drugs-dexamethasone and indomethacin--and an experimental specific cyclooxygenase-2 inhibitor, BF389, on the production of the pro-inflammatory cytokine IL-6 and the inflammatory mediator PGE2 by human astrocytes. Biofor 389 182-187 interleukin 6 Homo sapiens 240-244 9449430-6 1997 The non-specific cyclooxygenase inhibitor indomethacin and BF389 only suppressed the IL-6 release by post-mortem astrocyte culture A157. Biofor 389 59-64 interleukin 6 Homo sapiens 85-89 9449430-8 1997 Addition of exogenous PGE2 prevented the inhibitory effect of indomethacin and BF389 on the IL-1beta-activated IL-6 release from A157 astrocytes and largely potentiated the IL-1-induced release of IL-6 from all astrocytes/astroglioma cells tested. Biofor 389 79-84 interleukin 6 Homo sapiens 111-115 9449430-8 1997 Addition of exogenous PGE2 prevented the inhibitory effect of indomethacin and BF389 on the IL-1beta-activated IL-6 release from A157 astrocytes and largely potentiated the IL-1-induced release of IL-6 from all astrocytes/astroglioma cells tested. Biofor 389 79-84 interleukin 6 Homo sapiens 197-201 9359864-6 1997 D609, an inhibitor of ceramide production by acidic but not neutral sphingomyelinases, substantially inhibited induction of CRP and SAA by IL-6+IL-1beta. tricyclodecane-9-yl-xanthogenate 0-4 interleukin 6 Homo sapiens 139-143 9455080-3 1997 We investigated the effect of a new PDEI-III agent, olprinone, on IL-6 and IL-10 production during and after coronary bypass graft surgery (CABG). olprinone 52-61 interleukin 6 Homo sapiens 66-70 9390345-7 1997 Reverse transcription-polymerase chain reaction (RT-PCR) detected IL-6 mRNA in the lesional skin in all cases, levels of which were decreased after the effective intralesional steroid therapy, but which were unchanged after ineffective topical photochemotherapy (PUVA). puva 263-267 interleukin 6 Homo sapiens 66-70 9061040-1 1997 Cytomedical therapy for human interleukin-6 transgenic mice (hIL-6 Tgm) was implemented by the intraperitoneal injection of alginate-poly(L)lysine-alginate (APA) membranes microencapsulating SK2 hybridoma cells (APA-SK2 cells) which secrete anti-hIL-6 monoclonal antibodies (SK2 mAb). apa 157-160 interleukin 6 Homo sapiens 30-43 9061040-1 1997 Cytomedical therapy for human interleukin-6 transgenic mice (hIL-6 Tgm) was implemented by the intraperitoneal injection of alginate-poly(L)lysine-alginate (APA) membranes microencapsulating SK2 hybridoma cells (APA-SK2 cells) which secrete anti-hIL-6 monoclonal antibodies (SK2 mAb). apa 157-160 interleukin 6 Homo sapiens 61-66 9061040-1 1997 Cytomedical therapy for human interleukin-6 transgenic mice (hIL-6 Tgm) was implemented by the intraperitoneal injection of alginate-poly(L)lysine-alginate (APA) membranes microencapsulating SK2 hybridoma cells (APA-SK2 cells) which secrete anti-hIL-6 monoclonal antibodies (SK2 mAb). apa 157-160 interleukin 6 Homo sapiens 246-251 9373220-6 1997 Excess levels of the FK-506 analogue ascomycin reversed the antagonistic effect of rapamycin on IL-6 mediated growth suppression, suggesting that this biological action of rapamycin is mediated by a rapamycin/immunophilin complex. immunomycin 37-46 interleukin 6 Homo sapiens 96-100 22661192-8 2012 The ability of R-11 to affect interleukin- 6 (IL-6) production was determined in the whole human blood cell culture. trichlorofluoromethane 15-19 interleukin 6 Homo sapiens 46-50 22661192-11 2012 Supplementary experiments showed that R-11 was not toxic with regard to human peripheral blood mononuclear cells (PBMC) and that it upregulated IL-6 production in blood cell culture stimulated with lipopolysaccharide (LPS). trichlorofluoromethane 38-42 interleukin 6 Homo sapiens 144-148 22208783-11 2011 Early decreases in IL-6 serum levels with piroxicam correlated with better muscle performance at week 2. Piroxicam 42-51 interleukin 6 Homo sapiens 19-23 9495792-5 1997 However, in the activated microglia (amoeboid microglia) stimulated with Zymosan A, radiation-induced IL-6 mRNA expression was increased about two-fold in comparison with non-irradiation. Zymosan 73-82 interleukin 6 Homo sapiens 102-106 9378738-4 1997 Dibutyryl cAMP enhanced the synthesis of interleukin-6 by titanium-stimulated monocytes and resulted in a marked increase (maximum, seventyfold) in the synthesis of interleukin-6 even in the absence of titanium particles. dibutyryl 0-9 interleukin 6 Homo sapiens 41-54 9378738-4 1997 Dibutyryl cAMP enhanced the synthesis of interleukin-6 by titanium-stimulated monocytes and resulted in a marked increase (maximum, seventyfold) in the synthesis of interleukin-6 even in the absence of titanium particles. dibutyryl 0-9 interleukin 6 Homo sapiens 165-178 9135559-5 1997 The basal as well as IL-4, IL-6, IFN-gamma, TNF-alpha and TGF-beta-driven levels of HLA-ABC Ag were significantly diminished by calcitriol. Calcitriol 128-138 interleukin 6 Homo sapiens 27-31 9309381-6 1997 In human osteoblastic cells (SaOS2) both basal and TNF alpha-stimulated IL6 production were inhibited in a concentration-related manner by SK&F 86002 but not by indomethacin. saos2 29-34 interleukin 6 Homo sapiens 72-75 9172015-5 1996 In contrast, the stimulation of mRNA expression for IL-6 by Y-25510 was not suppressed by cycloheximide but suppressed by N alpha-p-tosyl-L-phenylalanine chloromethyl ketone (TPCK), an inhibitor of nuclear transcription factor-kappa B (NF-kappa B) activation, in the presence of LPS, suggesting that the stimulation requires NF-kappa activation. Cycloheximide 90-103 interleukin 6 Homo sapiens 52-56 21642586-0 2011 Fungal allergen beta-glucans trigger p38 mitogen-activated protein kinase-mediated IL-6 translation in lung epithelial cells. beta-Glucans 16-28 interleukin 6 Homo sapiens 83-87 9004165-8 1996 Vesnarinone inhibited IL-6 production and pimobendan slightly decreased IL-6 production, whereas amrinone had no significant effect on IL-6 production. vesnarinone 0-11 interleukin 6 Homo sapiens 22-26 9269644-15 1997 Il-6 release: Amino/Bic, 33.0 +/- 6.6%; Glu/Bic, 65.5 +/- 10.3%; Glu/Lac, 1.5 +/- 0.7% referred to RPMI). Lactose 69-72 interleukin 6 Homo sapiens 0-4 9269644-15 1997 Il-6 release: Amino/Bic, 33.0 +/- 6.6%; Glu/Bic, 65.5 +/- 10.3%; Glu/Lac, 1.5 +/- 0.7% referred to RPMI). rpmi 99-103 interleukin 6 Homo sapiens 0-4 21642586-4 2011 However, upon exposure of the lungs to fungal allergens, the direct contact of beta-glucans present in the fungus cell wall with lung epithelial cells is sufficient to trigger the rapid synthesis and secretion of IL-6 protein. beta-Glucans 79-91 interleukin 6 Homo sapiens 213-217 9253958-3 1997 Palmitoylethanolamide inhibited interleukin-4, interleukin-6, interleukin-8 synthesis and the production of p75 TNF-alpha soluble receptors at concentrations similar to those of anandamide but failed to influence TNF-alpha and interferon-gamma production. palmidrol 0-21 interleukin 6 Homo sapiens 47-60 8980876-2 1996 If added to cells activated by interferon gamma and lipopolysaccharide, radicicol analogue A not only inhibited the secretion of IL-1 beta but also induced an extremely rapid degradation of IL-1 beta, IL-6 and TNF-alpha mRNA to undetectable levels within 5-8 h. This degradation is independent of translation and of the signal inducing transcription. monorden 72-81 interleukin 6 Homo sapiens 201-205 21872324-4 2011 MAA beads decreased the expression of osteopontin (OPN) compared to poly(methyl methacrylate) (PMMA) and untreated cells, and increased the expression of IL-1beta, IL-6 and TNF-alpha over the 24-96 h of the experiment. monomethylarsonic acid 0-3 interleukin 6 Homo sapiens 164-168 16844037-7 1996 Treatment with neutralizing anti-human IL-6 antibodies reduced plasma IL-6 and G-CSF levels and significantly increased host carcass weight (16%) and fat mass (353%). carcass 125-132 interleukin 6 Homo sapiens 39-43 19856299-1 1997 This study demonstrates the changing levels of leukotrieneB4 (LTB4) and leukotrieneC4 (LTC4) generated by human white blood cells primed with different human interleukins IL-3, IL-5, IL-6, IL-8 and with human hematopoietic growth factor granulocyte-macrophage colony stimulating factor (GM-CSF). Leukotriene B4 47-60 interleukin 6 Homo sapiens 183-187 9184081-6 1997 An increase in cyclin B1 expression was also observed in irradiated HSF cells (synchronous and asynchronous), which decreased when the cells were treated with staurosporine or caffeine. Caffeine 176-184 interleukin 6 Homo sapiens 68-71 8774705-5 1996 The protein synthesis inhibitor cycloheximide is also a fairly strong inducer of IL-6 in these cells. Cycloheximide 32-45 interleukin 6 Homo sapiens 81-85 8774705-9 1996 Finally, when MCF-7 cells were treated with IL-1 beta or TNF-alpha in the presence of cycloheximide, transcription of IL-6 mRNA from the endogenous IL-6 gene was observed. Cycloheximide 86-99 interleukin 6 Homo sapiens 118-122 8774705-9 1996 Finally, when MCF-7 cells were treated with IL-1 beta or TNF-alpha in the presence of cycloheximide, transcription of IL-6 mRNA from the endogenous IL-6 gene was observed. Cycloheximide 86-99 interleukin 6 Homo sapiens 148-152 9161704-5 1997 DM650 antagonized IL-6 perfectly, resulting in the growth-inhibition of human myeloma AF-10 cells. dm650 0-5 interleukin 6 Homo sapiens 18-22 21320026-0 2011 Inhibitory effects of chelidonic acid on IL-6 production by blocking NF-kappaB and caspase-1 in HMC-1 cells. chelidonic acid 22-37 interleukin 6 Homo sapiens 41-45 9144567-0 1997 Protein synthesis inhibitors cycloheximide and anisomycin induce interleukin-6 gene expression and activate transcription factor NF-kappaB. Cycloheximide 29-42 interleukin 6 Homo sapiens 65-78 9144567-1 1997 In two human cell lines, MDA-MB-231 and HeLa, the inducible expression of the interleukin-6 (IL-6) gene by two protein synthesis inhibitors, cycloheximide and anisomycin, was compared with the induction by the most potent physiological inducer of IL-6 described to date, interleukin-1beta (IL-1beta). Cycloheximide 141-154 interleukin 6 Homo sapiens 78-91 9144567-2 1997 In cycloheximide or anisomycin treated cells, the accumulation of the IL-6 message and the activation of transcription factors required for IL-6 gene expression occurs at an extent similar to that obtained with IL-1beta. Cycloheximide 3-16 interleukin 6 Homo sapiens 70-74 9144567-2 1997 In cycloheximide or anisomycin treated cells, the accumulation of the IL-6 message and the activation of transcription factors required for IL-6 gene expression occurs at an extent similar to that obtained with IL-1beta. Cycloheximide 3-16 interleukin 6 Homo sapiens 140-144 11859379-8 1996 This inhibition of IL-6 expression by NDGA and indomethacin was dose responsive and also reversible with the addition of exogenous prostaglandin E(2) (PGE(2)) or leukotriene B(4) (LTB(4)). Leukotriene B4 162-175 interleukin 6 Homo sapiens 19-23 11859379-8 1996 This inhibition of IL-6 expression by NDGA and indomethacin was dose responsive and also reversible with the addition of exogenous prostaglandin E(2) (PGE(2)) or leukotriene B(4) (LTB(4)). Leukotriene B4 180-183 interleukin 6 Homo sapiens 19-23 8548766-2 1996 In human K562 erythroleukemic cells, PGA1 induces the synthesis of a M(r) 70,000 hsp (hsp70) by cycloheximide-sensitive activation of heat shock transcription factor (HSF). Cycloheximide 96-109 interleukin 6 Homo sapiens 134-165 8548766-2 1996 In human K562 erythroleukemic cells, PGA1 induces the synthesis of a M(r) 70,000 hsp (hsp70) by cycloheximide-sensitive activation of heat shock transcription factor (HSF). Cycloheximide 96-109 interleukin 6 Homo sapiens 167-170 21600592-8 2011 RESULTS: Preoperative plasma levels of the inflammatory cytokine interleukin-6 were reduced by 2-fold (P < .001) in the 2-dose methylprednisolone group, consistent with the anti-inflammatory effects of methylprednisolone. Methylprednisolone 130-148 interleukin 6 Homo sapiens 65-78 8689424-4 1996 Platelet-rich plasma (PRP) specimens from bolus IL-6-treated patients demonstrated an increased incorporation of actin-binding protein and myosin in the cytoskeletal core (triton insoluble residue) as shown by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) in comparison to control specimens. polyacrylamide 233-247 interleukin 6 Homo sapiens 48-52 7473161-5 1995 LY303870 antagonized in vitro NK-1 receptor effects as demonstrated by blockade of SP-stimulated phosphoinositide turnover in UC-11 MG human astrocytoma cells (Ki = 1.5 nM) and interleukin-6 secretion from U-373 MG human astrocytoma cells (Ki = 5 nM). sp 83-85 interleukin 6 Homo sapiens 177-190 9187959-8 1997 Pretreatment of EC with the protein synthesis inhibitor cycloheximide before their exposure to PAF resulted, after washout of the cycloheximide, in a markedly augmented production of IL-6, suggesting a synergy between augmented IL-6 mRNA accumulation by PAF and IL-6 mRNA superinduction by cycloheximide. Cycloheximide 56-69 interleukin 6 Homo sapiens 183-187 9187959-8 1997 Pretreatment of EC with the protein synthesis inhibitor cycloheximide before their exposure to PAF resulted, after washout of the cycloheximide, in a markedly augmented production of IL-6, suggesting a synergy between augmented IL-6 mRNA accumulation by PAF and IL-6 mRNA superinduction by cycloheximide. Cycloheximide 56-69 interleukin 6 Homo sapiens 228-232 9187959-8 1997 Pretreatment of EC with the protein synthesis inhibitor cycloheximide before their exposure to PAF resulted, after washout of the cycloheximide, in a markedly augmented production of IL-6, suggesting a synergy between augmented IL-6 mRNA accumulation by PAF and IL-6 mRNA superinduction by cycloheximide. Cycloheximide 56-69 interleukin 6 Homo sapiens 228-232 8576941-4 1995 Vesnarinone [OPC-8212; 3,4-dihydro-6-(4-(3,4-dimethoxybenzoil)-1-piperazinyl)-2(1H)- quinolinone] at 26 mumol/l significantly suppressed the production of IL-6, granulocyte macrophage colony stimulating factor (GM-CSF) and granulocyte colony stimulating factor (G-CSF) induced by IL-1 beta. vesnarinone 0-11 interleukin 6 Homo sapiens 155-159 8576941-4 1995 Vesnarinone [OPC-8212; 3,4-dihydro-6-(4-(3,4-dimethoxybenzoil)-1-piperazinyl)-2(1H)- quinolinone] at 26 mumol/l significantly suppressed the production of IL-6, granulocyte macrophage colony stimulating factor (GM-CSF) and granulocyte colony stimulating factor (G-CSF) induced by IL-1 beta. vesnarinone 13-21 interleukin 6 Homo sapiens 155-159 9363644-0 1997 Interleukin-1 beta and interleukin-6 stimulate 2-methylaminoisobutyric acid uptake in HepG2 cells. 2,2-dimethyl-beta-alanine 47-75 interleukin 6 Homo sapiens 23-36 21600592-8 2011 RESULTS: Preoperative plasma levels of the inflammatory cytokine interleukin-6 were reduced by 2-fold (P < .001) in the 2-dose methylprednisolone group, consistent with the anti-inflammatory effects of methylprednisolone. Methylprednisolone 205-223 interleukin 6 Homo sapiens 65-78 9363644-5 1997 Interleukin-1 beta and interleukin-6 (1000 U/ml) stimulated methylaminoisobutyric acid uptake by 36 +/- 6 and 41 +/- 4%, respectively (per cent +/- SD, n > or = 6). 2,2-dimethyl-beta-alanine 60-86 interleukin 6 Homo sapiens 23-36 9363644-9 1997 These data demonstrate that, in our culture conditions, interleukin-1 beta and interleukin-6 indirectly exert a stimulatory effect on methylaminoisobutyric acid transport in HepG2 cells. 2,2-dimethyl-beta-alanine 134-160 interleukin 6 Homo sapiens 79-92 21979989-9 2011 OCT inhibited PBMC proliferation and PBMC secretion of IL-6, IL-10 and IFN-gamma stimulated by GH. Octreotide 0-3 interleukin 6 Homo sapiens 55-59 7496871-9 1995 Zileuton reduced TNF and IL-6 release, but enhanced IL-1 release. zileuton 0-8 interleukin 6 Homo sapiens 25-29 20592661-4 2011 The angiotensin-converting enzyme inhibitors like captopril and enalapril as well as the angiotensin II receptor antagonist losartan indicated in HF exerted reducing effects on the inflammatory cytokines such as tumor necrosis factor-alpha and interleukin-6 at experimental and clinical levels. Losartan 124-132 interleukin 6 Homo sapiens 244-257 9138479-5 1997 On the other hand, PGE1 significantly increased type I collagenase activity and IL-8 production in the SDF culture supernatants and it increased IL-6 and TGF-beta(1) production in both types of fibroblasts. Alprostadil 19-23 interleukin 6 Homo sapiens 145-149 7627386-0 1995 Ranitidine reduces postoperative interleukin-6 induced C-reactive protein synthesis. Ranitidine 0-10 interleukin 6 Homo sapiens 33-46 21490132-0 2011 Celecoxib inhibits interleukin-6/interleukin-6 receptor-induced JAK2/STAT3 phosphorylation in human hepatocellular carcinoma cells. Celecoxib 0-9 interleukin 6 Homo sapiens 19-46 7627386-4 1995 STUDY DESIGN: The effect of perioperative ranitidine on postoperative change in plasma interleukin-6 (IL-6) and serum C-reactive protein (CRP) levels was assessed in 23 women undergoing elective abdominal hysterectomy. Ranitidine 42-52 interleukin 6 Homo sapiens 87-100 7627386-4 1995 STUDY DESIGN: The effect of perioperative ranitidine on postoperative change in plasma interleukin-6 (IL-6) and serum C-reactive protein (CRP) levels was assessed in 23 women undergoing elective abdominal hysterectomy. Ranitidine 42-52 interleukin 6 Homo sapiens 102-106 7627386-11 1995 However, the reduced CRP level in ranitidine-treated patients suggests that H2RAs modulate IL-6 signal transduction in hepatic cells. Ranitidine 34-44 interleukin 6 Homo sapiens 91-95 9350477-7 1997 Besides the gamma-carboxylation of osteocalcin vitamin K may also affect other parameters of bone metabolism, such as calcium hemostasis, and prostaglandin E2 and interleukin 6 production. Vitamin K 47-56 interleukin 6 Homo sapiens 163-176 21490132-5 2011 We also explored whether the anticancer effects of celecoxib, an anti-inflammatory drug, may be due to the inhibition of the IL-6/STAT3 pathway in HCC cells. Celecoxib 51-60 interleukin 6 Homo sapiens 125-129 21490132-7 2011 Celecoxib could also block exogenous IL-6-induced STAT3 phosphorylation and nuclear translocation. Celecoxib 0-9 interleukin 6 Homo sapiens 37-41 21490132-10 2011 Celecoxib may be a candidate for HCC therapy through blocking IL-6/STAT3 pathway and can be combined with other anticancer drugs to reduce drug resistance caused by IL-6/STAT3 signals. Celecoxib 0-9 interleukin 6 Homo sapiens 62-66 8824277-0 1996 Inhibition of NFkappaB activity through maintenance of IkappaBalpha levels contributes to dihydrotestosterone-mediated repression of the interleukin-6 promoter. Dihydrotestosterone 90-109 interleukin 6 Homo sapiens 137-150 8824277-4 1996 In a series of co-transfection assays, we found that 5alpha-dihydrotestosterone, through the androgen receptor, repressed activation of the interleukin-6 promoter, in part, by inhibiting NFkappaB activity. Dihydrotestosterone 53-79 interleukin 6 Homo sapiens 140-153 7643018-4 1995 Fc epsilon RII was also triggered by IFN-gamma, TNF-alpha, and IL-6 on all the cell lines, an effect blocked by calcitriol. Calcitriol 112-122 interleukin 6 Homo sapiens 63-67 21490132-10 2011 Celecoxib may be a candidate for HCC therapy through blocking IL-6/STAT3 pathway and can be combined with other anticancer drugs to reduce drug resistance caused by IL-6/STAT3 signals. Celecoxib 0-9 interleukin 6 Homo sapiens 165-169 21388428-7 2011 Addition of the p38 MAP kinase inhibitor SB202190 decreased MO IL-6/TNF-alpha production upon OK-432 stimulation in a dose-dependent manner. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 41-49 interleukin 6 Homo sapiens 63-67 8573814-5 1995 In addition, glucose metabolism, urea synthesis, P450 dependent verapamil metabolism using high performance liquid chromatography, and interleukin-6 induced "acute phase" reaction by sulfodesoxysalicylic acid-polyacrylamide gel electrophoresis detected changes of albumin synthesis were determined in primary hepatocytes and in established liver cells. polyacrylamide 209-223 interleukin 6 Homo sapiens 135-148 8695842-3 1996 In M1mycer cells, when endogenous c-myc expression has been suppressed following stimulation by interleukin-6 (IL-60), treatment with estrogen and cycloheximide results in induction of ODC transcripts. Cycloheximide 147-160 interleukin 6 Homo sapiens 96-109 22140321-0 2011 IL-6-induced pathophysiology during pre-eclampsia: potential therapeutic role for magnesium sulfate? Magnesium Sulfate 82-99 interleukin 6 Homo sapiens 0-4 8832295-8 1996 This reduction in Cd-B was related to the reduction in Cd-F (GM for Cd-F was 38.0 micrograms/day in the 1980 study and 30.0 micrograms/day in the 1990 study). cd-b 18-22 interleukin 6 Homo sapiens 55-59 8832295-8 1996 This reduction in Cd-B was related to the reduction in Cd-F (GM for Cd-F was 38.0 micrograms/day in the 1980 study and 30.0 micrograms/day in the 1990 study). cd-b 18-22 interleukin 6 Homo sapiens 68-72 8523572-5 1996 Induction of IL-6 in B cells by EBV could be mimicked by treatment with the protein kinase C (PKC) activator phorbol 12,13-dibutyrate but not with the calcium ionophore ionomycin. Phorbol 12,13-Dibutyrate 109-133 interleukin 6 Homo sapiens 13-17 7621072-5 1995 The functional significance of this ligand pairing was demonstrated by triggering CD11b and CD11c on monocytes with either recombinant CD23 or anti-CD11b and anti-CD11c MAbs to cause a marked increase in nitrite-oxidative products and pro-inflammatory cytokines (IL-1 beta, IL-6, and TNF alpha). Nitrites 204-211 interleukin 6 Homo sapiens 274-278 7674091-5 1995 Both IL-6 at 100 ng/ml and soluble IL-6 receptor protein in the absence of exogenous IL-6 inhibited the stimulatory effect of 1,25(OH)2 vitamin D3. Calcitriol 126-146 interleukin 6 Homo sapiens 5-9 22140321-7 2011 The focus of this review is to discuss the cascade of events leading to cytokines, specifically interleukin-6 (IL-6), in stimulating vasoactive substances such as AT1-AA (Figure 1) and to examine the mechanism whereby administration of magnesium sulfate can be beneficial during pre-eclampsia. Magnesium Sulfate 236-253 interleukin 6 Homo sapiens 96-109 7674091-5 1995 Both IL-6 at 100 ng/ml and soluble IL-6 receptor protein in the absence of exogenous IL-6 inhibited the stimulatory effect of 1,25(OH)2 vitamin D3. Calcitriol 126-146 interleukin 6 Homo sapiens 35-39 7674091-5 1995 Both IL-6 at 100 ng/ml and soluble IL-6 receptor protein in the absence of exogenous IL-6 inhibited the stimulatory effect of 1,25(OH)2 vitamin D3. Calcitriol 126-146 interleukin 6 Homo sapiens 35-39 22140321-7 2011 The focus of this review is to discuss the cascade of events leading to cytokines, specifically interleukin-6 (IL-6), in stimulating vasoactive substances such as AT1-AA (Figure 1) and to examine the mechanism whereby administration of magnesium sulfate can be beneficial during pre-eclampsia. Magnesium Sulfate 236-253 interleukin 6 Homo sapiens 111-115 7594457-8 1995 The transcription factor NF-kappa B appears to play a central role in CD40-mediated activation of the IL-6 gene; NF-kappa B mobilization directly preceded CD40-mediated IL-6 production, and suppression of NF-kappa B mobilization with the metabolic inhibitor D609 also suppressed the IL-6 response. tricyclodecane-9-yl-xanthogenate 258-262 interleukin 6 Homo sapiens 102-106 22140321-9 2011 Another potential area of benefit with magnesium sulfate administration may be to decrease inflammatory responses or decrease cardiovascular mechanisms stimulated by overexpression of inflammatory cytokines in response to placental ischemia or animal models of elevated IL-6 during pregnancy. Magnesium Sulfate 39-56 interleukin 6 Homo sapiens 270-274 21362045-7 2011 A significant, positive correlation was seen between TNF-alpha and IL-6 and between blood ammonia and TNF-alpha, IL-6, and brain glutamine. Ammonia 90-97 interleukin 6 Homo sapiens 113-117 8592949-6 1995 Alendronate exhibited dose-dependent inhibition of the production of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) by activated monocytes. Alendronate 0-11 interleukin 6 Homo sapiens 101-114 8592949-6 1995 Alendronate exhibited dose-dependent inhibition of the production of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) by activated monocytes. Alendronate 0-11 interleukin 6 Homo sapiens 116-120 7669718-4 1995 Treatment with IL-6 increased the susceptibility of these cells to induction of apoptosis by Adriamycin or cycloheximide, but treatment with DEX or with IL-6 and DEX did not. Cycloheximide 107-120 interleukin 6 Homo sapiens 15-19 7729284-5 1995 Furthermore, immunofluorescent microscopic study of active IBD specimens showed more conspicuous staining of IL-6 in infiltrating LPMC (mostly CD68+ cells) and colonic epithelial cells. lpmc 130-134 interleukin 6 Homo sapiens 109-113 7558422-4 1995 Exposure to IL-6 markedly decreased dihydrotestosterone (DHT)-induced apo-D and GCDFP-15 release, with a half-maximal effect measured at 13 U/ml. Dihydrotestosterone 36-55 interleukin 6 Homo sapiens 12-16 21605007-4 2011 RESULTS: At baseline, the purines AMP and hypoxanthine correlated with multiple inflammatory markers including neutrophil counts and the cytokines interleukin (IL)-6, IL-8, tumor necrosis factor alpha (TNF-alpha), and IL-1beta (r ranged from 0.41 to 0.66, all P < 0.05). Purines 26-33 interleukin 6 Homo sapiens 147-165 7558422-4 1995 Exposure to IL-6 markedly decreased dihydrotestosterone (DHT)-induced apo-D and GCDFP-15 release, with a half-maximal effect measured at 13 U/ml. Dihydrotestosterone 57-60 interleukin 6 Homo sapiens 12-16 7530507-4 1995 We have analyzed the prognostic significance of serum immunoreactive IL-6, as measured by a sensitive immunosorbent assay, in 210 patients with newly diagnosed MM subsequently treated with intermittent melphalan and prednisone. Prednisone 216-226 interleukin 6 Homo sapiens 69-73 20466551-8 2011 Significant correlations were found between intraarticular IL-6 concentrations and KSS and WOMAC scores at the first month according to the Pearson correlation test, but no correlations were found between serum IL-6 and CRP levels and KSS and WOMAC scores. KSS 83-86 interleukin 6 Homo sapiens 59-63 7780040-6 1995 In contrast, the known translational inhibitor cycloheximide did not demonstrate selectivity for IL-6; this agent decreased the GM-CSF-induced increase in total translational activity in parallel with its effects on IL-6. Cycloheximide 47-60 interleukin 6 Homo sapiens 216-220 7619053-9 1995 Although pretreatment with cycloheximide inhibits 125I-IL-6 binding, IFN-alpha does not cause a selective decrease in the levels of gp130 or IL-6 receptor mRNA at times when 125I-IL-6 binding is inhibited. Cycloheximide 27-40 interleukin 6 Homo sapiens 55-59 7605904-6 1995 The level of interleukin-6 (IL-6) in the culture supernatants was significantly increased one day after the addition of 1.0 microgram/ml UBX. N-[(S)-({[(Benzyloxy)carbonyl]amino}methyl)(Hydroxy)phosphoryl]-N-Methyl-L-Leucinamide 137-140 interleukin 6 Homo sapiens 13-26 22282962-8 2011 Nigericin also decreased the concentrations of IL-4 and IL-6 with IC50 values of less than 1 ng/ml. Nigericin 0-9 interleukin 6 Homo sapiens 56-60 7605904-6 1995 The level of interleukin-6 (IL-6) in the culture supernatants was significantly increased one day after the addition of 1.0 microgram/ml UBX. N-[(S)-({[(Benzyloxy)carbonyl]amino}methyl)(Hydroxy)phosphoryl]-N-Methyl-L-Leucinamide 137-140 interleukin 6 Homo sapiens 28-32 7829668-2 1994 They are able to produce cytokines like interleukin 6 (IL-6) and depolarize substantially after stimulation by lipopolysaccharides (LPS) or leukotriene B4 (LTB4). Leukotriene B4 140-154 interleukin 6 Homo sapiens 55-59 7926489-7 1994 CONCLUSIONS: Because 3H release reflects [3H]norepinephrine release, our results show that IL-6 exerts a dual effect on norepinephrine release. [3H]norepinephrine 41-59 interleukin 6 Homo sapiens 91-95 8617376-4 1995 Treatment with nitrogranulogen (NG), a derivative of cyclophosphamide, changes the isoenzyme pattern in line 59 and decreases severalfold IL6 production, while in similarly treated line 63 cells isoenzyme pattern remains unaffected but the production of IL6 is significantly increases. Mechlorethamine 15-30 interleukin 6 Homo sapiens 138-141 21385538-7 2011 CONCLUSIONS: Our study demonstrates significantly higher serum levels of IL-6 and TNF-alpha in patients with MC+HCV and MC+AT compared to healthy controls. mc+hcv 109-115 interleukin 6 Homo sapiens 73-77 8617376-4 1995 Treatment with nitrogranulogen (NG), a derivative of cyclophosphamide, changes the isoenzyme pattern in line 59 and decreases severalfold IL6 production, while in similarly treated line 63 cells isoenzyme pattern remains unaffected but the production of IL6 is significantly increases. Mechlorethamine 15-30 interleukin 6 Homo sapiens 254-257 8617376-4 1995 Treatment with nitrogranulogen (NG), a derivative of cyclophosphamide, changes the isoenzyme pattern in line 59 and decreases severalfold IL6 production, while in similarly treated line 63 cells isoenzyme pattern remains unaffected but the production of IL6 is significantly increases. Mechlorethamine 32-34 interleukin 6 Homo sapiens 138-141 8617376-4 1995 Treatment with nitrogranulogen (NG), a derivative of cyclophosphamide, changes the isoenzyme pattern in line 59 and decreases severalfold IL6 production, while in similarly treated line 63 cells isoenzyme pattern remains unaffected but the production of IL6 is significantly increases. Mechlorethamine 32-34 interleukin 6 Homo sapiens 254-257 7993580-4 1994 IL-6 together with wtAcMNPV DNAs were transferred into cultured lepidopteran insect cells (Sf9) by calcium phosphate coprecipitation procedure. calcium phosphate 99-116 interleukin 6 Homo sapiens 0-4 8049434-5 1994 Of various cytokines tested, tumor necrosis factor-alpha (TNF-alpha) alone counteracted GM2- and GM3-induced inhibitions of Ig production and thymidine uptake, whereas other cytokines including IL-1 beta, IL-3, IL-5, IL-6, and interferon-gamma each failed to do so. gm2 88-91 interleukin 6 Homo sapiens 217-221 21385538-8 2011 Furthermore, the study first shows a significant increase in circulating IL-6 observed in MC+AT patients with respect to MC+HCV. mc+hcv 121-127 interleukin 6 Homo sapiens 73-77 21461372-3 2011 In this study, we evaluated the effectiveness of doxycycline and tetracycline to modulate serum levels of IL-6, IL-1B, and TNF and cytokine receptor/receptor antagonist TNF-R1 and IL-1RA in patients with DF or DHF. Doxycycline 49-60 interleukin 6 Homo sapiens 106-110 7982993-3 1994 Using HeLa cells as an example, we demonstrated that dithiothreitol (DTT,2mM) inhibited the heat (42 degrees C) induced increase in the synthesis of heat shock proteins (HSPs), abundance of mRNA of hsp 70, hsp 70 gene promoter activity, and the heat shock factor (HSF) DNA binding activity. Dithiothreitol 53-67 interleukin 6 Homo sapiens 245-262 7982993-3 1994 Using HeLa cells as an example, we demonstrated that dithiothreitol (DTT,2mM) inhibited the heat (42 degrees C) induced increase in the synthesis of heat shock proteins (HSPs), abundance of mRNA of hsp 70, hsp 70 gene promoter activity, and the heat shock factor (HSF) DNA binding activity. Dithiothreitol 53-67 interleukin 6 Homo sapiens 264-267 7982993-3 1994 Using HeLa cells as an example, we demonstrated that dithiothreitol (DTT,2mM) inhibited the heat (42 degrees C) induced increase in the synthesis of heat shock proteins (HSPs), abundance of mRNA of hsp 70, hsp 70 gene promoter activity, and the heat shock factor (HSF) DNA binding activity. Dithiothreitol 69-72 interleukin 6 Homo sapiens 245-262 20557713-7 2011 Results of Live/Dead and pro-inflammatory cytokine expression analyses showed that the exposure of ARPE-19 cultures to the test materials cross-linked with a concentration >=0.1 mmol EDC/mg GM induces significant cytotoxicity and high levels of interleukin-1beta and interleukin-6. ethylene dichloride 186-189 interleukin 6 Homo sapiens 270-283 7982993-3 1994 Using HeLa cells as an example, we demonstrated that dithiothreitol (DTT,2mM) inhibited the heat (42 degrees C) induced increase in the synthesis of heat shock proteins (HSPs), abundance of mRNA of hsp 70, hsp 70 gene promoter activity, and the heat shock factor (HSF) DNA binding activity. Dithiothreitol 69-72 interleukin 6 Homo sapiens 264-267 7982993-7 1994 Analysis of the effects of DTT on the regulation and function of HSF suggests that DTT blocked an early and important step in the activation process without having a direct effect on the HSF protein. Dithiothreitol 27-30 interleukin 6 Homo sapiens 65-68 7982993-7 1994 Analysis of the effects of DTT on the regulation and function of HSF suggests that DTT blocked an early and important step in the activation process without having a direct effect on the HSF protein. Dithiothreitol 83-86 interleukin 6 Homo sapiens 65-68 7982993-8 1994 Thus, DTT inhibited the heat-induced trimerization, phosphorylation, and nuclear translocation of HSF and was also effective against a number of other reagents that are known to activate HSF. Dithiothreitol 6-9 interleukin 6 Homo sapiens 98-101 7982993-8 1994 Thus, DTT inhibited the heat-induced trimerization, phosphorylation, and nuclear translocation of HSF and was also effective against a number of other reagents that are known to activate HSF. Dithiothreitol 6-9 interleukin 6 Homo sapiens 187-190 7628063-3 1994 The effect to increase plasma corticosterone was consonant with the well-known action of IL-6 on the hypothalamus-pituitary-adrenal cortex. Corticosterone 30-44 interleukin 6 Homo sapiens 89-93 7628063-4 1994 IL-6 produced a transient increase in plasma glucagon that was mirrored by elevated plasma glucose and a depletion of hepatic glycogen. Glycogen 126-134 interleukin 6 Homo sapiens 0-4 8000705-6 1994 Following PGE1 treatment, IL-1 alpha and TGF alpha from HDFs remained undetectable while IL-6 production was enhanced markedly. Alprostadil 10-14 interleukin 6 Homo sapiens 89-93 8000705-13 1994 These results indicate that fibroblasts are more sensitive than keratinocytes in response to PGE1 and that, upon PGE1 stimulation, HDF-derived IL-6 may play an essential role in NHK cell proliferation which may at least partly account for the beneficial effects of PGE1 in the treatment of cutaneous ulcerations. Alprostadil 113-117 interleukin 6 Homo sapiens 143-147 8000705-13 1994 These results indicate that fibroblasts are more sensitive than keratinocytes in response to PGE1 and that, upon PGE1 stimulation, HDF-derived IL-6 may play an essential role in NHK cell proliferation which may at least partly account for the beneficial effects of PGE1 in the treatment of cutaneous ulcerations. Alprostadil 113-117 interleukin 6 Homo sapiens 143-147 8206884-6 1994 Recombinant hIL-6 carries one O-linked carbohydrate chain, and Thr139 is fully O-glycosylated. linked carbohydrate 32-51 interleukin 6 Homo sapiens 12-17 8206884-7 1994 A portion of recombinant hIL-6 protein carries one N-linked sialooligosaccharide chain, and the N-glycosylation occurs at Asn46. n-linked sialooligosaccharide 51-80 interleukin 6 Homo sapiens 25-30 20832949-12 2011 Previous studies in experimental models of cirrhosis and cirrhotic patients have demonstrated that long-term administration of oral antibiotics such as trimethoprim-sulfamethoxazole, norfloxacin, and rifaximin can reduce bacterial translocation and circulating levels of endotoxin, TNF-alpha, IL-6, and NO. Trimethoprim, Sulfamethoxazole Drug Combination 152-181 interleukin 6 Homo sapiens 293-297 8106631-12 1994 Treatment of 2 such patients with prednisone was associated with a dramatic reduction and prompt normalization of IL-6 and thyroid hormone values. Prednisone 34-44 interleukin 6 Homo sapiens 114-118 7523165-4 1994 The combination of bFGF, interleukin-3 (IL-3), IL-6, and stem cell factor (SCF) resulted in a transduction efficiency of 37 and 35% for G418-resistant colony-forming units-granulocyte/macrophage (CFU-GM) and mixed colonies multipotent colony-forming units (CFU-GEMM), respectively, which was significantly higher than the corresponding figures obtained with IL-3, IL-6, and SCF. antibiotic G 418 136-140 interleukin 6 Homo sapiens 47-51 7927744-1 1994 Mycoplasma arginini TUH-14 partially purified membrane lipoproteins (TUH-14-pp) directly induce secretion of the cytokines involved in the inflammatory response, namely, interleukin 1 (IL-1), tumor necrosis factor alpha, and IL-6, by human monocytes cultured in the absence of serum. tuh-14-pp 69-78 interleukin 6 Homo sapiens 225-229 20832949-12 2011 Previous studies in experimental models of cirrhosis and cirrhotic patients have demonstrated that long-term administration of oral antibiotics such as trimethoprim-sulfamethoxazole, norfloxacin, and rifaximin can reduce bacterial translocation and circulating levels of endotoxin, TNF-alpha, IL-6, and NO. Norfloxacin 183-194 interleukin 6 Homo sapiens 293-297 7927744-3 1994 Upon stimulation with either TUH-14-pp or lipopolysaccharide, most tumor necrosis factor alpha and IL-6 is secreted in the extracellular compartment, whereas a significant amount of IL-1 remains cell associated. tuh-14-pp 29-38 interleukin 6 Homo sapiens 99-103 8202627-0 1994 Inhibition of IL-6 and IL-8 production in human fibroblast cell lines by 1,25 (OH)2 vitamin D3 and two of its analogs with lower calcemic activity. Calcitriol 73-94 interleukin 6 Homo sapiens 14-18 7529912-4 1994 Agents which mimicked (dibutyryl cAMP) or stimulated (isoproterenol and forskolin) cAMP formation were found to induce IL-6 release and their effects could be potentiated by 3-isobutyl-1-methylxanthine (IBMX), a phosphodiesterase inhibitor. dibutyryl 23-32 interleukin 6 Homo sapiens 119-123 20798552-7 2011 Following inhibition of p38 MAPK with the specific inhibitor SB-202190, levels of TNF-alpha and IL-6 significantly decreased in neonatal and adult blood, whereas pharmacological inhibition of NF-kappaB with SC-514 showed no significant effect on cytokine expression. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 61-70 interleukin 6 Homo sapiens 96-100 8069925-7 1994 PGE1, a cAMP agonist, caused a 30-fold induction of IL-6 secretion. Alprostadil 0-4 interleukin 6 Homo sapiens 52-56 7970084-7 1994 Cycloheximide inhibited IL-6 production without irreversible cell toxicity, indicating de-novo synthesis. Cycloheximide 0-13 interleukin 6 Homo sapiens 24-28 20729385-7 2010 Pretreatment with budesonide, a currently used inhaled corticosteroid, decreased LPS-induced expression of TNF-alpha, IL-6, and IL-8, and reduced LPS-induced neutrophilia by ~84%. Budesonide 18-28 interleukin 6 Homo sapiens 118-122 8247258-3 1993 It has been shown that DBI33-50, in concentration between 10(-6)-10(-8) M, enhances the LPS-induced secretion of IL-6, as determined by specific bioassay for this monokine. dbi33 23-28 interleukin 6 Homo sapiens 113-117 8047839-10 1994 Incubation of GEC with recombinant (r) IL-6 resulted in a dose dependent increase in 3H thymidine incorporation indicating that IL-6 acts as an autocrine growth factor for GEC. 3h thymidine 85-97 interleukin 6 Homo sapiens 39-43 8047839-10 1994 Incubation of GEC with recombinant (r) IL-6 resulted in a dose dependent increase in 3H thymidine incorporation indicating that IL-6 acts as an autocrine growth factor for GEC. 3h thymidine 85-97 interleukin 6 Homo sapiens 128-132 7831669-2 1994 Platelet-rich plasma (PRP) incubated with IL-6 showed a dose dependent enhancement of agonist induced maximum aggregation (AIMA) and secretion of thromboxane B2 (TXB2) as measured by RIA, in short term incubations. Thromboxane B2 146-160 interleukin 6 Homo sapiens 42-46 20807870-7 2010 Consistently, magnesium intake was significantly inversely associated with hs-CRP, IL-6, fibrinogen, and HOMA-IR, and serum magnesium levels were inversely correlated with hs-CRP and HOMA-IR. Magnesium 14-23 interleukin 6 Homo sapiens 83-87 7938085-5 1994 Here the authors present data which suggests that PGs including thromboxane B2 (TXB2) and their precursors such as dihomo-gamma linolenic acid (DGLA), arachidonic acid (AA) and eicosapentaenoic acid (EPA) can inhibit T-cell proliferation and influence their ability to secrete IL-2, IL-4, IL-6 and TNF in vitro. Thromboxane B2 64-78 interleukin 6 Homo sapiens 289-293 7938085-5 1994 Here the authors present data which suggests that PGs including thromboxane B2 (TXB2) and their precursors such as dihomo-gamma linolenic acid (DGLA), arachidonic acid (AA) and eicosapentaenoic acid (EPA) can inhibit T-cell proliferation and influence their ability to secrete IL-2, IL-4, IL-6 and TNF in vitro. 8,11,14-Eicosatrienoic Acid 115-142 interleukin 6 Homo sapiens 289-293 8307982-8 1994 By using the protein synthesis inhibitor cycloheximide, it was shown that G(Anh)MTetra-induced IL-6 mRNA expression depends on the synthesis of new protein, whereas G(Anh)MTetra-induced IL-1 beta mRNA accumulation does not. Cycloheximide 41-54 interleukin 6 Homo sapiens 95-99 8326131-5 1993 This antiserum was found to block, in a dose-dependent manner, 1) zymosan-induced neutrophil chemotaxis, 2) C5a-induced enzyme release from neutrophils, and 3) C5a-induced cytokine production (IL-6 and IL-8) from human monocytes in vitro. Zymosan 66-73 interleukin 6 Homo sapiens 193-197 8425178-5 1993 This effect of IL-6 on ir-ET-1 secretion was inhibited by actinomycin D and cycloheximide, indicating that IL-6 stimulates de novo synthesis of ir-ET-1 at a transcriptional level. Cycloheximide 76-89 interleukin 6 Homo sapiens 15-19 8425178-5 1993 This effect of IL-6 on ir-ET-1 secretion was inhibited by actinomycin D and cycloheximide, indicating that IL-6 stimulates de novo synthesis of ir-ET-1 at a transcriptional level. Cycloheximide 76-89 interleukin 6 Homo sapiens 107-111 8289985-4 1993 Calcitriol therapy resulted in significant increases in the phorbol myristate acetate (PMA)-induced secretion of IL-1 and IL-6 (p = 0.04 and 0.03, respectively). Calcitriol 0-10 interleukin 6 Homo sapiens 122-126 21124781-10 2010 Only aliskiren was able to significantly reduce stroke-induced gene expression of CXC chemokine ligand 1, interleukin-6 and tumor necrosis factor-alpha in the ischemic core. aliskiren 5-14 interleukin 6 Homo sapiens 106-151 1493924-4 1992 Further, 1,25(OH)2D3 inhibited the release of IL-6 in cultures of PHA-activated PBMC, whereas it stimulated IL-6 with the addition of PMA in these cultures. Calcitriol 9-20 interleukin 6 Homo sapiens 46-50 1493924-4 1992 Further, 1,25(OH)2D3 inhibited the release of IL-6 in cultures of PHA-activated PBMC, whereas it stimulated IL-6 with the addition of PMA in these cultures. Calcitriol 9-20 interleukin 6 Homo sapiens 108-112 1493924-5 1992 In contrast to the PHA-activated cells, 1,25(OH)2D3 increased IL-6 release in OKT3-activated cells. Calcitriol 40-51 interleukin 6 Homo sapiens 62-66 1431212-0 1992 Cytokine-stimulated human dermal microvascular endothelial cells produce interleukin 6--inhibition by hydrocortisone, dexamethasone, and calcitriol. Calcitriol 137-147 interleukin 6 Homo sapiens 73-86 1431212-5 1992 The effects of hydrocortisone, dexamethasone, calcitriol, acitretin, and cyclosporin A on TNF- or IL-1 beta-induced IL-6 production by HDMEC were determined by ELISA. Calcitriol 46-56 interleukin 6 Homo sapiens 116-120 1431212-9 1992 As IL-6 seems to play a key role in the pathogenesis of psoriasis, the beneficial effects of corticosteroids and calcitriol in this disease may partly be explained by their ability to inhibit HDMEC-derived IL-6 production. Calcitriol 113-123 interleukin 6 Homo sapiens 206-210 8020547-3 1994 Binding experiments with 125I-labeled IL-6 showed that IL-6R were expressed at a high density on RPMI-8226 cells (15 000 receptors/cell), but no specific binding was detected on XG-1 cells, whose growth depends on the presence of exogenous IL-6. rpmi 97-101 interleukin 6 Homo sapiens 55-59 8020547-5 1994 Treatment of RPMI-8226 cells with IL-6 reduced the number of IL-6R without changing their affinity. rpmi 13-17 interleukin 6 Homo sapiens 34-38 8244994-3 1993 In lipopolysaccharide-stimulated human whole blood, the OH radical scavenger dimethyl sulfoxide (Me2SO) dramatically inhibited (approximately 90%) IL-8 production, but had minimal effects on the production of tumor necrosis factor, interleukin 1 beta (IL-1), and IL-6. oh radical 56-66 interleukin 6 Homo sapiens 263-267 8244994-3 1993 In lipopolysaccharide-stimulated human whole blood, the OH radical scavenger dimethyl sulfoxide (Me2SO) dramatically inhibited (approximately 90%) IL-8 production, but had minimal effects on the production of tumor necrosis factor, interleukin 1 beta (IL-1), and IL-6. me2so 97-102 interleukin 6 Homo sapiens 263-267 20953204-0 2010 Rimonabant inhibits TNF-alpha-induced endothelial IL-6 secretion via CB1 receptor and cAMP-dependent protein kinase pathway. Rimonabant 0-10 interleukin 6 Homo sapiens 50-54 8403509-11 1993 Exposure of PBMC to SMX-HA resulted in a modest increase in the production of IL-6, IL-1 beta and TNF-alpha, although no major difference was detected between subjects with or without hypersensitivity. Sulfamethoxazole 20-23 interleukin 6 Homo sapiens 78-82 1327803-0 1992 Leukotriene B4 transcriptionally activates interleukin-6 expression involving NK-chi B and NF-IL6. Leukotriene B4 0-14 interleukin 6 Homo sapiens 43-56 1548355-5 1992 Treatment of decidual cells with actinomycin D or cycloheximide abrogated the increase in IL-6 production induced by IL-1 beta. Cycloheximide 50-63 interleukin 6 Homo sapiens 90-94 20953204-4 2010 RESULTS: Rimonabant at 1 and 10 mumol/L significantly inhibited TNF-alpha-induced IL-6 production when added 15, 30 and 60 minutes before TNF-alpha treatment. Rimonabant 9-19 interleukin 6 Homo sapiens 82-86 8216257-3 1993 In addition, vesnarinone inhibits production of TNF-alpha and IL-6 by human peripheral blood mononucleated cells stimulated with LPS. vesnarinone 13-24 interleukin 6 Homo sapiens 62-66 21037437-2 2010 BACKGROUND: Recent experimental data suggest that PTX, a tumor necrosis factor (TNF) alpha inhibitor, enhances liver regeneration and reduces ischemic injury through activation of the interleukin-6 (IL-6) signaling pathway. Pentoxifylline 50-53 interleukin 6 Homo sapiens 184-197 8376548-6 1993 We found detectable levels of IL-6 in the CSF of 57% of GBS, 43% of CIDP, 60% of IND, 75% of BT, and 4% of NIND. indole 81-84 interleukin 6 Homo sapiens 30-34 8376548-8 1993 Serum IL-6 levels were increased in six of 23 (26%) GBS, in one of 39 (3%) NIND, and in one of seven (14%) IND, but in none of the CIDP or BT patients. indole 76-79 interleukin 6 Homo sapiens 6-10 1303974-5 1992 Cd-B correlated significantly with Cd-F when compared on a regional mean basis. cd-b 0-4 interleukin 6 Homo sapiens 35-39 21037437-2 2010 BACKGROUND: Recent experimental data suggest that PTX, a tumor necrosis factor (TNF) alpha inhibitor, enhances liver regeneration and reduces ischemic injury through activation of the interleukin-6 (IL-6) signaling pathway. Pentoxifylline 50-53 interleukin 6 Homo sapiens 199-203 1665302-0 1991 Leukotriene B4 up-regulates IL-6 rather than IL-1 synthesis in human monocytes. Leukotriene B4 0-14 interleukin 6 Homo sapiens 28-32 21037437-10 2010 There was a 3.6-fold stronger induction of IL-6 mRNA for the PTX group (P < 0.001). Pentoxifylline 61-64 interleukin 6 Homo sapiens 43-47 7682456-2 1993 The effect of stem cell factor (SCF), interleukin-6 (IL-6), and basic fibroblast growth factor (bFGF) on myeloid colony proliferation of PBHP was determined. 21-amino-6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-1,4,7,10,13,16,19-heptazacyclotricosane-2,5,8,11,14,17,20-heptone;sulfuric acid 137-141 interleukin 6 Homo sapiens 53-57 1665302-1 1991 Leukotriene B4 (LTB4) preferentially induced IL-6 mRNA accumulation and IL-6 protein release as assessed by ELISA and the B9 cell bioassay. Leukotriene B4 0-14 interleukin 6 Homo sapiens 45-49 21037437-15 2010 The study demonstrates beneficial effects of PTX on regeneration of small remnant livers (RLBW ratio <= 1.2%) that seems to be mediated by IL-6. Pentoxifylline 45-48 interleukin 6 Homo sapiens 142-146 1665302-1 1991 Leukotriene B4 (LTB4) preferentially induced IL-6 mRNA accumulation and IL-6 protein release as assessed by ELISA and the B9 cell bioassay. Leukotriene B4 0-14 interleukin 6 Homo sapiens 72-76 7681633-6 1993 These effects were dose dependent with a concentration of 2 x 10(-9) M PGE1, 5 x 10(-6) M forskolin, 5 x 10(-4) M DBcAMP, and 1 x 10(-3) M IBMX decreasing rIL-1 alpha (2.5 ng/ml)-induced IL-6 production by approximately 50%. Alprostadil 71-75 interleukin 6 Homo sapiens 187-191 21042414-1 2010 5-Androstene-3beta,7beta,17beta-triol (beta-AET), an active metabolite of dehydroepiandrosterone (DHEA), reversed glucocorticoid (GC)-induced suppression of IL-6, IL-8 and osteoprotegerin production by human osteoblast-like MG-63 cells and promoted osteoblast differentiation of human mesenchymal stem cells (MSCs). 17beta-triol 25-37 interleukin 6 Homo sapiens 157-161 7681633-10 1993 Nuclear run-on analysis demonstrated that the inhibitory effects of PGE1 were associated with a comparable decrease in IL-6 transcription. Alprostadil 68-72 interleukin 6 Homo sapiens 119-123 1879927-5 1991 The number of TNF-alpha- and IL-6-secreting cells in either lipopolysaccharide- or muramyl dipeptide-stimulated mononuclear cells from tuberculin-positive healthy subjects and patients was significantly higher than that in cells from the tuberculin-negative healthy subjects. Acetylmuramyl-Alanyl-Isoglutamine 83-100 interleukin 6 Homo sapiens 29-33 8472015-1 1993 The effects of synthetic alkyl ((alkyl 6-deoxy-a-D-gluco-heptopyranosyluronate) 6-deoxy-a-D-gluco-heptopyranoside) uronates, a novel type of mirror pseudo cord factor, on the in vitro modulation of interleukin-6 production and T-cell proliferation in human peripheral blood mononuclear cells, were investigated. alkyl ((alkyl 6-deoxy-a-d-gluco-heptopyranosyluronate) 6-deoxy-a-d-gluco-heptopyranoside) uronates 25-123 interleukin 6 Homo sapiens 198-211 21042414-1 2010 5-Androstene-3beta,7beta,17beta-triol (beta-AET), an active metabolite of dehydroepiandrosterone (DHEA), reversed glucocorticoid (GC)-induced suppression of IL-6, IL-8 and osteoprotegerin production by human osteoblast-like MG-63 cells and promoted osteoblast differentiation of human mesenchymal stem cells (MSCs). Dehydroepiandrosterone 74-96 interleukin 6 Homo sapiens 157-161 1864979-2 1991 We investigated the IL-6 requirements for the growth of two human myeloma cell lines, U 266 and RPMI 8226. rpmi 96-100 interleukin 6 Homo sapiens 20-24 21042414-1 2010 5-Androstene-3beta,7beta,17beta-triol (beta-AET), an active metabolite of dehydroepiandrosterone (DHEA), reversed glucocorticoid (GC)-induced suppression of IL-6, IL-8 and osteoprotegerin production by human osteoblast-like MG-63 cells and promoted osteoblast differentiation of human mesenchymal stem cells (MSCs). Dehydroepiandrosterone 98-102 interleukin 6 Homo sapiens 157-161 20668435-4 2010 The results of this study showed that DHA reduced expressions of tumor necrosis factor-alpha, interleukin-6, nitric oxide synthase, and cyclo-oxygenase-2, induced by interferon-gamma, and induced upregulation of heme oxygenase-1 (HO-1) in BV-2 microglia. Docosahexaenoic Acids 38-41 interleukin 6 Homo sapiens 94-107 1721559-6 1991 The stimulation of iE adhesion to HSF induced by kE as well as kE binding to the cells could be inhibited by lactose and laminin but not by Arg-Gly-Asp-Ser(RGDS) peptides. Lactose 109-116 interleukin 6 Homo sapiens 34-37 1382861-8 1992 This enhancement is abrogated by pretreatment of effector cells with cycloheximide, suggesting that protein synthesis is required for IL-6 to enhance LAK cell activity. Cycloheximide 69-82 interleukin 6 Homo sapiens 134-138 1281784-5 1992 The most potent combination of growth factors that we examined, interleukin 1 (IL-1)/IL-3/IL-6/MGF, resulted in the conferral of G418 resistance to 45% of progenitors and long-term culture-initiating cells. antibiotic G 418 129-133 interleukin 6 Homo sapiens 90-94 1394624-3 1992 We report here the in vitro activation of HSF by treating at 0 degrees C a HeLa cell-free system with the aldehyde 4-hydroxynonenal (HNE), a highly cytotoxic product of lipid peroxidation. Aldehydes 106-114 interleukin 6 Homo sapiens 42-45 2050135-4 1991 Solubilization of the protein with 6 M guanidine hydrochloride and refolding in the presence of a reduction/oxidation system results in a quantitative recovery of recombinant human interleukin-6. Guanidine 39-62 interleukin 6 Homo sapiens 181-194 20696864-4 2010 Surprisingly, however, whereas mRNA expression and cellular release of TNF-alpha, the beta form of pro-IL-1 (IL-1beta), and IL-6 were inhibited by the leptomycin B-induced nuclear IkappaBalpha, IL-8 mRNA expression and cellular release were not significantly affected. leptomycin B 151-163 interleukin 6 Homo sapiens 124-128 2033081-2 1991 The 25-kDa O-glycosylated IL-6 (which contains only Ser- or Thr-GalNAc-Gal-NeuNAc and thus should not bind wheat germ or lentil lectins) bound to and was eluted from a wheat germ lectin affinity column by GlcNAc and from a lentil lectin affinity column by methyl-alpha-D-Man suggesting that the 25-kDa IL-6 species formed heteromeric complexes with the N-glycosylated 30-kDa IL-6. 2-acetamido-2-deoxy-4-O-(beta-2-acetamid-2-deoxyglucopyranosyl)glucopyranose 205-211 interleukin 6 Homo sapiens 26-30 1323342-0 1992 Leukotriene B4 enhances interleukin-6 (IL-6) production and IL-6 messenger RNA accumulation in human monocytes in vitro: transcriptional and posttranscriptional mechanisms. Leukotriene B4 0-14 interleukin 6 Homo sapiens 24-37 1323342-0 1992 Leukotriene B4 enhances interleukin-6 (IL-6) production and IL-6 messenger RNA accumulation in human monocytes in vitro: transcriptional and posttranscriptional mechanisms. Leukotriene B4 0-14 interleukin 6 Homo sapiens 39-43 1323342-0 1992 Leukotriene B4 enhances interleukin-6 (IL-6) production and IL-6 messenger RNA accumulation in human monocytes in vitro: transcriptional and posttranscriptional mechanisms. Leukotriene B4 0-14 interleukin 6 Homo sapiens 60-64 1294020-7 1992 IL-6 transcripts were strongly superinduced after cycloheximide treatment, suggesting that a labile protein regulates IL-6 mRNA levels in these cells. Cycloheximide 50-63 interleukin 6 Homo sapiens 0-4 1710480-1 1991 The regulation of granulocyte-colony stimulating factor (G-CSF) and interleukin-6 (IL-6) mRNA was studied in human adherent monocytes in response to the protein kinase C activator, oleolyl-acetylglycerol (OAG), the calcium-ionophore A23187 and the cyclic AMP elevating agents, dibutyryl c-AMP (DBcAMP), cholera toxin and isobutyl-methylxanthine (IBMX). oleolyl-acetylglycerol 181-203 interleukin 6 Homo sapiens 68-81 20843335-3 2010 The aim of this study was to evaluate the effects of PHT and its metabolite, 5-(p-hydroxyphenyl-), 5-phenylhydantoin (HPPH) on LPS-elicited MMP, TIMP, TNF-alpha and IL-6 levels in macrophages. hydroxyphenytoin 77-116 interleukin 6 Homo sapiens 165-169 1710480-1 1991 The regulation of granulocyte-colony stimulating factor (G-CSF) and interleukin-6 (IL-6) mRNA was studied in human adherent monocytes in response to the protein kinase C activator, oleolyl-acetylglycerol (OAG), the calcium-ionophore A23187 and the cyclic AMP elevating agents, dibutyryl c-AMP (DBcAMP), cholera toxin and isobutyl-methylxanthine (IBMX). oleolyl-acetylglycerol 181-203 interleukin 6 Homo sapiens 83-87 1294020-7 1992 IL-6 transcripts were strongly superinduced after cycloheximide treatment, suggesting that a labile protein regulates IL-6 mRNA levels in these cells. Cycloheximide 50-63 interleukin 6 Homo sapiens 118-122 1294622-4 1992 Among the beta-lactams the most active were the cephalosporins (cephalexin, cefamandol, ceftazidin, and a sulbactam-ampicillin combination) in inducing the release of TNF, IL-1 alpha, and IL-6 from monocytes, and releasing IL-4 and IFN-tau from lymphocytes. beta-Lactams 10-22 interleukin 6 Homo sapiens 188-192 20843335-3 2010 The aim of this study was to evaluate the effects of PHT and its metabolite, 5-(p-hydroxyphenyl-), 5-phenylhydantoin (HPPH) on LPS-elicited MMP, TIMP, TNF-alpha and IL-6 levels in macrophages. hydroxyphenytoin 118-122 interleukin 6 Homo sapiens 165-169 1339917-4 1992 As compared to the controls, IL-6 production induced by PHA and ConA on Day 4 of the culture was suppressed by an average 60-70% when methyl B12 (80-8,000 ng/ml) was added to the medium. mecobalamin 134-144 interleukin 6 Homo sapiens 29-33 1885209-9 1991 Inhibition of production and function of IL-6 may therefore be involved in 1,25-(OH)2D3-mediated regulation of lymphocyte functions in vitro. Calcitriol 75-87 interleukin 6 Homo sapiens 41-45 21073054-9 2010 The levels of IL-6 and Wolbachia DNA in the plasma were significantly lower in the doxycycline group. Doxycycline 83-94 interleukin 6 Homo sapiens 14-18 1871801-6 1991 Both, CsA and high doses of diltiazem caused an increase of IL-6 mRNA. Diltiazem 28-37 interleukin 6 Homo sapiens 60-64 20185740-6 2010 Compared with weight loss alone, ezetimibe plus weight loss significantly (all P < 0.05) decreased IHTG content (-18%), plasma hs-CRP (-53%), interleukin-6 (-24%), LDL cholesterol (-18%), campesterol (-59%), and apoB-100 (-14%) levels, with a significant increase in plasma lathosterol concentrations (+43%). Ezetimibe 33-42 interleukin 6 Homo sapiens 145-158 1710149-3 1991 However, the addition of IL-1 alpha to CD34+ DR+ cultures containing IL-6 resulted in the appearance of CFU-MK-derived colonies, suggesting that IL-6 requires the presence of IL-1 alpha to exhibit its MK colony-stimulating activity (MK-CSA). mk-csa 233-239 interleukin 6 Homo sapiens 145-149 1710149-5 1991 The addition of either anti-IL-6, anti-IL-1 alpha, or anti-IL-3 antisera to cultures containing both IL-6 and IL-1 alpha totally abolished the MK-CSA of the IL-6/IL-1 alpha combination. mk-csa 143-149 interleukin 6 Homo sapiens 28-32 1710149-5 1991 The addition of either anti-IL-6, anti-IL-1 alpha, or anti-IL-3 antisera to cultures containing both IL-6 and IL-1 alpha totally abolished the MK-CSA of the IL-6/IL-1 alpha combination. mk-csa 143-149 interleukin 6 Homo sapiens 101-105 1710149-5 1991 The addition of either anti-IL-6, anti-IL-1 alpha, or anti-IL-3 antisera to cultures containing both IL-6 and IL-1 alpha totally abolished the MK-CSA of the IL-6/IL-1 alpha combination. mk-csa 143-149 interleukin 6 Homo sapiens 101-105 1680274-4 1991 Using H1 receptor (cetirizin and loderix) and H2 receptor (cimetidine and ranitidine) specific antagonists, an H1-dependent stimulation of IL-6 binding by CESS cells was found. Ranitidine 74-84 interleukin 6 Homo sapiens 139-143 2002092-4 1991 IL-6 was found in the CSF of 29% of MS, 7% of NIND, and 47% of IND patients. indole 47-50 interleukin 6 Homo sapiens 0-4 2002092-6 1991 CSF IL-6 and TNF alpha levels were significantly higher in MS and IND than in NIND. indole 66-69 interleukin 6 Homo sapiens 4-8 2002092-13 1991 Our results indicate that increased CSF levels of the cytokines IL-6 and TNF alpha occur frequently in MS and IND, but there is no obvious relationship to intrathecal Ig synthesis. indole 110-113 interleukin 6 Homo sapiens 64-68 20388003-8 2010 Budesonide significantly attenuated the release and expression of IL-6 and IL-8 after exposure. Budesonide 0-10 interleukin 6 Homo sapiens 66-70 1846109-5 1991 Human IL-1 beta and human IL-6 also showed a stimulatory effect on corticosterone production, whereas human IL-2 was inactive in this system. Corticosterone 67-81 interleukin 6 Homo sapiens 26-30 2048428-5 1991 rIL-1 alpha, PTH, and 1,25-(OH)2D3 induced IL-6 release by calvariae. Calcitriol 22-34 interleukin 6 Homo sapiens 43-47 2048428-4 1991 IL-6 did not affect resorption stimulated by human recombinant IL-1 alpha (rIL-1 alpha) but inhibited resorption stimulated by parathyroid hormone (PTH) and 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]. Calcitriol 157-181 interleukin 6 Homo sapiens 0-4 2048428-4 1991 IL-6 did not affect resorption stimulated by human recombinant IL-1 alpha (rIL-1 alpha) but inhibited resorption stimulated by parathyroid hormone (PTH) and 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]. Calcitriol 183-195 interleukin 6 Homo sapiens 0-4 20388003-11 2010 Budesonide reduced IL-6 and IL-8 production and enhanced expression of TLR2 in PBECs only in the presence of a proinflammatory stimulus. Budesonide 0-10 interleukin 6 Homo sapiens 19-23 1987687-1 1991 Serum interleukin 6 (IL-6) levels were utilized as an immunologic marker of activation of T cells and macrophages in renal allograft recipients treated with a cyclosporine and prednisone immunosuppressive regimen. Prednisone 176-186 interleukin 6 Homo sapiens 21-25 20351184-6 2010 The NF-kappaB pathway inhibitor BAY-11, JNK inhibitor JNKi II, and p38 inhibitor SB203580 suppressed the synergistic effect of IL-6 and IL-17 on IL-6 expression. bay-11 32-38 interleukin 6 Homo sapiens 127-131 2347366-4 1990 IL 6 from the culture medium of transfected NIH/3T3 cells exhibited at least eight bands on Western blots after sodium dodecyl sulfate-polyacrylamide gel electrophoresis, indicating that human IL 6 expressed in NIH/3T3 cells shows a complex glycosylation pattern. polyacrylamide 135-149 interleukin 6 Homo sapiens 193-197 2269476-3 1990 Lipopylosaccharide (LPS) or Borrelia burgdorferi spirochetes (Bb) were used to induce TNF-alpha and IL-6 production in cultures. lipopylosaccharide 0-18 interleukin 6 Homo sapiens 100-104 2081193-3 1990 The combination of IL-3 plus IL-6 consistently produced significantly higher levels of G418-resistant colonies (50-60%) than any of the other combinations of HGF tested. antibiotic G 418 87-91 interleukin 6 Homo sapiens 29-33 20351184-6 2010 The NF-kappaB pathway inhibitor BAY-11, JNK inhibitor JNKi II, and p38 inhibitor SB203580 suppressed the synergistic effect of IL-6 and IL-17 on IL-6 expression. bay-11 32-38 interleukin 6 Homo sapiens 145-149 19823118-12 2010 Thus, this study shows that one possible mechanism involved in ketamine-induced inhibition of LTA-induced TNF-alpha and IL-6 gene expressions and oxidative stress production is through downregulating TLR2-mediated phosphorylation of ERK1/2 and the subsequent translocation and transactivation of NFkappaB. Ketamine 63-71 interleukin 6 Homo sapiens 120-124 1693528-6 1990 Furthermore, mRNA for IL-6 and IL-1 beta was dramatically superinduced by the combination of cycloheximide and TNF alpha. Cycloheximide 93-106 interleukin 6 Homo sapiens 22-26 2154372-6 1990 On the contrary, both quantitative and qualitative changes in the alpha binding can be detected with extracts from uninduced cells or from cells treated with IL-6 or IL-6 + cycloheximide. Cycloheximide 173-186 interleukin 6 Homo sapiens 166-170 20102371-3 2010 A short heptapeptide that selectively binds to IL-6R and which inhibits the effect of IL-6 was coupled to the magnetic resonance imaging (MRI) contrast agent gadolinium (Gd)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and the fluorescent dye rhodamine. Gadolinium 158-170 interleukin 6 Homo sapiens 47-51 1688564-7 1990 Cycloheximide (CHX), inhibitor of protein synthesis, also markedly increased levels of IL-6 mRNA. Cycloheximide 0-13 interleukin 6 Homo sapiens 87-91 1688564-7 1990 Cycloheximide (CHX), inhibitor of protein synthesis, also markedly increased levels of IL-6 mRNA. Cycloheximide 15-18 interleukin 6 Homo sapiens 87-91 1716487-2 1990 In this study, we report the effects of prostaglandin E2 (PGE2), and two other cAMP-elevating agents, dibutyryl cAMP and 3-isobutyl-1-methyl-xanthine, on the in vitro LPS-induced production of IL 6, IL 1 alpha, IL 1 beta and TNF alpha by human monocytes. dibutyryl 102-111 interleukin 6 Homo sapiens 193-197 2105993-0 1990 Human polysaccharide-specific B cells are responsive to pokeweed mitogen and IL-6. Polysaccharides 6-20 interleukin 6 Homo sapiens 77-81 20229495-6 2010 Significantly higher values of cytokines in monocell cultures were measured in the PFH group compared to the control group (IL-6 = 139.32 +/- 80.84 pg/ml versus 14.30 +/- 12.97 pg/ml, p < 0.001 and TNF-a = 39.91 +/- 11.80 pg/ml versus 8.65 +/- 4.35 pg/ml, p < 0.001). N-n-Propyl-N-formylhydrazine 83-86 interleukin 6 Homo sapiens 124-128 2105993-11 1990 Finally, anti-IL-6 antibody blocked PWM-induced total and polysaccharide-specific antibody production. Polysaccharides 58-72 interleukin 6 Homo sapiens 14-18 2105993-12 1990 We conclude that human polysaccharide-specific B cells are responsive to PWM and IL-6. Polysaccharides 23-37 interleukin 6 Homo sapiens 81-85 33971977-6 2021 RESULTS: Pre-incubating WI-38 cells with low and medium concentrations GA protected LPS-induced cell death, apoptosis and inflammatory protein productions of IL-6 and MCP-1. gambogic acid 71-73 interleukin 6 Homo sapiens 158-162 33146542-6 2021 Exposing hPACs and PAC 266-6 to pro-inflammatory cytokines (hyper IL-6, TNF-alpha, and IL-1beta) was found to lead to a significant inhibition in thiamin uptake. Thiamine 146-153 interleukin 6 Homo sapiens 66-70 1690177-1 1990 We studied IL-6 gene expression in human monocytes stimulated by muramyl dipeptide (MDP), a synthetic immunomodulator derived from mycobacterial cell walls. Acetylmuramyl-Alanyl-Isoglutamine 65-82 interleukin 6 Homo sapiens 11-15 20470305-0 2010 Pentoxifylline improves haemoglobin and interleukin-6 levels in chronic kidney disease. Pentoxifylline 0-14 interleukin 6 Homo sapiens 40-53 29600943-11 2018 Daily prednisone dose had an inverse association with lower serum IL-4, IL6, IL-17A, IL-17E, IL-22 and IL-23. Prednisone 6-16 interleukin 6 Homo sapiens 72-75 10862623-1 2000 Modulation of HSF by vanadate and wortmannin. Vanadates 21-29 interleukin 6 Homo sapiens 14-17 34078115-6 2022 IL-6 inhibitors (sirukumab, tocilizumab, sarilumab) significantly enhance metabolism via CYP2C9 (s-warfarin), CYP2C19 (omeprazole), and CYP3A4 (simvastatin, midazolam) and reduce metabolism via CYP1A2 (caffeine). Caffeine 202-210 interleukin 6 Homo sapiens 0-4 34843717-0 2022 Luxeptinib Disables NLRP3 Inflammasome-Mediated IL-1beta release and Pathways Required for Secretion of Inflammatory Cytokines IL-6 and TNFalpha. Luxeptinib 0-10 interleukin 6 Homo sapiens 127-131 34843717-6 2022 The aim of this study was to determine the extent to which luxeptinib interferes with the release of IL-1beta, IL-6 and TNFalpha from THP-1 monocytes and bone marrow-derived macrophages following endotoxin exposure and priming of the NLRP3 inflammasome. Luxeptinib 59-69 interleukin 6 Homo sapiens 111-115 22792085-6 2012 Our results showed that fenofibrate inhibited transforming growth factor-beta (TGF-beta) and IL-6-induced differentiation of Th17 cells in vitro. Fenofibrate 24-35 interleukin 6 Homo sapiens 93-97 20470305-1 2010 AIM: To assess whether pentoxifylline improves anaemia of chronic kidney disease (CKD) via suppression of interleukin-6 (IL-6) and improved iron mobilization. Pentoxifylline 23-37 interleukin 6 Homo sapiens 106-119 34843717-10 2022 Implications: The ability of luxeptinib to inhibit the NLRP3-mediated release of IL-1beta and pathways involved in the release of IL-6 and TNFalpha at concentrations which are well-tolerated in patients makes it a candidate for the treatment of inflammatory diseases and inflammation-associated resistance in cancer. Luxeptinib 29-39 interleukin 6 Homo sapiens 130-134 20470305-1 2010 AIM: To assess whether pentoxifylline improves anaemia of chronic kidney disease (CKD) via suppression of interleukin-6 (IL-6) and improved iron mobilization. Pentoxifylline 23-37 interleukin 6 Homo sapiens 121-125 34088250-0 2022 NSAIDs/Nitazoxanide/Azithromycin Repurposed for COVID-19: Potential Mitigation of the Cytokine Storm Interleukin-6 Amplifier via Immunomodulatory Effects. Azithromycin 20-32 interleukin 6 Homo sapiens 101-114 20470305-4 2010 In experimental models, pentoxifylline was shown to reduce IL-6 expression. Pentoxifylline 24-38 interleukin 6 Homo sapiens 59-63 19180502-10 2009 After up-regulation of NOD-2 by TLR ligands, its ligand muramyl dipeptide (MDP) increased the expression of IL-6 and IL-8 via p38 and NF-kappaB. Acetylmuramyl-Alanyl-Isoglutamine 56-73 interleukin 6 Homo sapiens 108-112 20470305-11 2010 Treatment with pentoxifylline reduced circulating IL-6 (6.6 + or - 1.6 pg/mL, P < 0.01), increased transferrin saturation (20 + or - 5%, P < 0.003) and decreased serum ferritin (81 + or - 25 microg/L, P = NS). Pentoxifylline 15-29 interleukin 6 Homo sapiens 50-54 19180502-10 2009 After up-regulation of NOD-2 by TLR ligands, its ligand muramyl dipeptide (MDP) increased the expression of IL-6 and IL-8 via p38 and NF-kappaB. Acetylmuramyl-Alanyl-Isoglutamine 75-78 interleukin 6 Homo sapiens 108-112 34888704-7 2022 In addition, we show that AC injection leads to elevated blood sera IL-6 levels and altered cytokine mRNA expression within the brain. Actinium 26-28 interleukin 6 Homo sapiens 68-72 20470305-13 2010 CONCLUSIONS: Pentoxifylline reduces circulating IL-6 and improves haemoglobin in non-inflammatory moderate to severe CKD. Pentoxifylline 13-27 interleukin 6 Homo sapiens 48-52 34402375-6 2021 Firstly, we found that Tamsulosin reduced high glucose-induced expressions of TNF-alpha, IL-6, and IL-8. Tamsulosin 23-33 interleukin 6 Homo sapiens 89-93 34236247-9 2022 17,18-EpETE significantly inhibited tumor necrosis factor (TNF)-alpha-induced production of interleukin (IL)-6 , IL-8, and mucin from cultured human airway epithelial cells dose dependently, and these antiinflammatory effects on cytokine production were abolished by GW1100, a selective GPR40 antagonist. 17,18-epoxy-5,8,11,14-eicosatetraenoic acid 0-11 interleukin 6 Homo sapiens 92-110 20067446-0 2010 H2S transiently blocks IL-6 expression in rheumatoid arthritic fibroblast-like synoviocytes and deactivates p44/42 mitogen-activated protein kinase. Hydrogen Sulfide 0-3 interleukin 6 Homo sapiens 23-27 34785108-16 2022 In vivo and in vitro, YDJDG exerted anti-inflammatory effects by inhibiting the production of inflammatory cytokines (IL-6, IL-1beta, and TNF-alpha). ydjdg 22-27 interleukin 6 Homo sapiens 118-122 34363189-7 2021 Clarithromycin use was associated with decreases in circulating C-reactive protein, tumour necrosis factor-alpha and interleukin (IL)-6; by increase of production of interferon-gamma and decrease of production of interleukin-6 by mononuclear cells; and by suppression of SARS-CoV-2 viral load. Clarithromycin 0-14 interleukin 6 Homo sapiens 117-135 34363189-7 2021 Clarithromycin use was associated with decreases in circulating C-reactive protein, tumour necrosis factor-alpha and interleukin (IL)-6; by increase of production of interferon-gamma and decrease of production of interleukin-6 by mononuclear cells; and by suppression of SARS-CoV-2 viral load. Clarithromycin 0-14 interleukin 6 Homo sapiens 213-226 34948051-7 2021 This IL-6 release could be blocked by a Galphaq inhibitor (YM-254890), an IKK complex inhibitor (IKK-16), and partly by a PLC inhibitor (U-73122). 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 137-144 interleukin 6 Homo sapiens 5-9 20067446-11 2010 Long-term exposure of FLSs to H2S provides stimulatory effects, leading to reinforced activation of p38 MAPK and ERK1/2 accompanied by upregulation of IL-6 expression. Hydrogen Sulfide 30-33 interleukin 6 Homo sapiens 151-155 20047583-8 2010 CONCLUSION: An IL-6-mediated endothelium dependent NO-cyclic guanine monophosphate-mediated relaxation pathway may be inhibited in systemic vessels in pre-eclampsia. cyclic guanine monophosphate 54-82 interleukin 6 Homo sapiens 15-19 34607230-8 2021 Besides, in patients, receiving lovastatin the CRP, IL-6, IL-8 levels were significantly decreased from T1 to T3 than to the control group. Lovastatin 32-42 interleukin 6 Homo sapiens 52-56 34582847-5 2021 LPC stimulation resulted in elevated secretion of interleukin (IL)-6 and IL-8 in HUVECs, accompanied with the activation of ER stress and NF-kappaB pathway. lpc 0-3 interleukin 6 Homo sapiens 50-68 20005739-10 2010 Activation of IL-6-hsCRP pathway may play a specific role in ADHF with LVSDF. lvsdf 71-76 interleukin 6 Homo sapiens 14-18 34834246-6 2021 Low-dose MR prednisone seems to be able to improve the course of RA, reduce morning stiffness and morning serum levels of IL-6, and induce significant clinical benefits. Prednisone 12-22 interleukin 6 Homo sapiens 122-126 34411723-13 2021 The more common fracture patterns were oblique, transverse, wedge, and comminuted in HE-HSF. Helium 85-87 interleukin 6 Homo sapiens 88-91 20130114-6 2010 Activation of TRL4 by lipopolysaccharide (LPS) and TLR1/2 by Pam(3)Cys up-regulates IL-6 and MCP-1 release in adipocytes via specific activation of Erk. trl4 14-18 interleukin 6 Homo sapiens 84-88 19811770-0 2010 Sodium selenite inhibits the expression of VEGF, TGFbeta(1) and IL-6 induced by LPS in human PC3 cells via TLR4-NF-(K)B signaling blockage. Sodium Selenite 0-15 interleukin 6 Homo sapiens 64-68 34831016-5 2021 IL6 serum levels significantly correlated with disease-free survival and 18F-FDG PET/CT uptake, an indirect measurement of tumour glycolysis and, hence, of acidosis. Fluorodeoxyglucose F18 73-80 interleukin 6 Homo sapiens 0-3 34669255-12 2021 Pharmacological profile revealed that the treatment of DO and D3 inhibited the production of pro-inflammatory cytokines (TNF-alpha, IL-6) induced by lipopolysaccharide (LPS) in primary macrophages without any cytotoxic effect after administration of their effective concentrations. do 55-57 interleukin 6 Homo sapiens 132-136 34669255-12 2021 Pharmacological profile revealed that the treatment of DO and D3 inhibited the production of pro-inflammatory cytokines (TNF-alpha, IL-6) induced by lipopolysaccharide (LPS) in primary macrophages without any cytotoxic effect after administration of their effective concentrations. Cholecalciferol 62-64 interleukin 6 Homo sapiens 132-136 34438042-2 2021 Here we demonstrate that the hydrophobic bile acid, deoxycholic acid (DCA), stimulated the production of IL-6 and IL-8 mRNA and protein in Het-1A, a model of normal oesophageal cells. Deoxycholic Acid 52-68 interleukin 6 Homo sapiens 105-109 34438042-2 2021 Here we demonstrate that the hydrophobic bile acid, deoxycholic acid (DCA), stimulated the production of IL-6 and IL-8 mRNA and protein in Het-1A, a model of normal oesophageal cells. Deoxycholic Acid 70-73 interleukin 6 Homo sapiens 105-109 34867400-6 2021 Furthermore, using an approved clinical durgs library, we found two clinical drugs, Cepharanthine and Glucosamine, significantly inhibited ACE2 level, IFNbeta level, and NF-kappaB signaling downstream TNFalpha and IL6 levels. Glucosamine 102-113 interleukin 6 Homo sapiens 214-217 34438042-3 2021 DCA-induced production of IL-6 and IL-8 was attenuated by pharmacologic inhibition of the Protein Kinase C (PKC), MAP kinase, tyrosine kinase pathways, by the cholesterol sequestering agent, methyl-beta-cyclodextrin (MCD) and by the hydrophilic bile acid, ursodeoxycholic acid (UDCA). Deoxycholic Acid 0-3 interleukin 6 Homo sapiens 26-30 20377994-7 2010 After amlodipine administration, a significant decrease (p less than 0.01) was observed in the serum TNF-alpha and IL-6 levels. Amlodipine 6-16 interleukin 6 Homo sapiens 115-119 34438042-4 2021 The cholesterol-interacting agent, nystatin, which binds cholesterol without removing it from the membrane, synergized with DCA to induce IL-6 and IL-8. Deoxycholic Acid 124-127 interleukin 6 Homo sapiens 138-142 34438042-8 2021 Taken together, these results demonstrate that DCA stimulates IL-6 and IL-8 production in oesophageal cells via lipid raft-associated signaling. Deoxycholic Acid 47-50 interleukin 6 Homo sapiens 62-66 34754315-10 2021 Molecular docking results showed that quercetin, luteolin, kaempferol, tanshinone IIa, wogonin, naringenin, nobiletin, dihydrotanshinlactone, beta-sitosterol, and salviolone have good affinity with core target proteins IL6, PTGS2, MAPK1, MAPK3, and CGRP1. Luteolin 49-57 interleukin 6 Homo sapiens 219-222 34836187-7 2021 Although patients with severe hypovitaminosis-D showed no significant increase in IL-6 levels, acute COVID-19 patients manifested high circulating IL-6 at admission (females = 127.64 +- 22.24 pg/mL, males = 139.28 +- 48.95 ng/mL) which dropped drastically after the administration of 1alpha,25(OH)2D3 (1.84 +- 0.77 pg/mL and 2.65 +- 0.92 ng/mL, respectively). Calcitriol 284-300 interleukin 6 Homo sapiens 82-86 34836187-7 2021 Although patients with severe hypovitaminosis-D showed no significant increase in IL-6 levels, acute COVID-19 patients manifested high circulating IL-6 at admission (females = 127.64 +- 22.24 pg/mL, males = 139.28 +- 48.95 ng/mL) which dropped drastically after the administration of 1alpha,25(OH)2D3 (1.84 +- 0.77 pg/mL and 2.65 +- 0.92 ng/mL, respectively). Calcitriol 284-300 interleukin 6 Homo sapiens 147-151 34600695-6 2021 Further, RT-PCR for inflammatory mediators (TRPA1, NF-kappaB, PPAR-gamma, COX-2, IL-6, TNF, FPR2, FAAH, MAGL, and IL-12A) induced by carrageenan, NLRP3 inflammasome activation, and the cell viability were then accessed. Carrageenan 133-144 interleukin 6 Homo sapiens 81-85 34790130-6 2021 Our results reveal the effect of iBMSC-derived IL6 on TME-induced malignant transformation of NB cells, and provide theoretical basis for the clinical application of LPC as a potential IL6 inhibitor in high-risk refractory NB patients. lpc 166-169 interleukin 6 Homo sapiens 47-50 34790130-6 2021 Our results reveal the effect of iBMSC-derived IL6 on TME-induced malignant transformation of NB cells, and provide theoretical basis for the clinical application of LPC as a potential IL6 inhibitor in high-risk refractory NB patients. lpc 166-169 interleukin 6 Homo sapiens 185-188 34654829-9 2021 Furthermore, MGO was positively correlated with markers of systemic inflammation (IL-6, p = 0.004) and the development of ascites (p = 0.013). Pyruvaldehyde 13-16 interleukin 6 Homo sapiens 82-86 20413861-8 2010 Stimulation by rAbeta42 also induces the production of the pro-inflammatory cytokines IL-1beta, IL-6, IFN-gamma, and TNF-alpha, and of the anti-inflammatory cytokines IL-10 and IL-1Ra. rabeta42 15-23 interleukin 6 Homo sapiens 96-100 34608940-15 2022 The serum levels of IL-1beta and IL-6 were positive correlated with the urinary 1-OH-P levels in bitumen fumes exposed workers. Oxaliplatin 80-86 interleukin 6 Homo sapiens 33-37 34684771-12 2021 Attenuation of S1-induced transcription of IL-6 and IL-1beta by the MAPK kinase inhibitor U0126 was greater than that by the Akt inhibitor perifosine, and the effects were potentiated by simultaneous treatment with both inhibitors. U 0126 90-95 interleukin 6 Homo sapiens 43-47 34087397-12 2021 Moreover, as the main bioactive compounds of DSS, paeoniflorin (PF), ferulic acid (FA) and pachymic acid (PA) inhibited IL-6 and TNF-alpha secretion as well as IkappaB-alpha, NF-kappaB (p65), p38 and JNK activation. pachymic acid 91-104 interleukin 6 Homo sapiens 120-124 34087397-12 2021 Moreover, as the main bioactive compounds of DSS, paeoniflorin (PF), ferulic acid (FA) and pachymic acid (PA) inhibited IL-6 and TNF-alpha secretion as well as IkappaB-alpha, NF-kappaB (p65), p38 and JNK activation. pachymic acid 106-108 interleukin 6 Homo sapiens 120-124 21516735-5 2010 RESULTS: The lornoxicam group exhibited a significant reduction in CRP and a decrease in IL-6. lornoxicam 13-23 interleukin 6 Homo sapiens 89-93 34576295-4 2021 The administration of O2-O3 gas mixtures induced multiple effects on fibroblasts, depending on their activation state: in non-activated fibroblasts, O3 stimulated proliferation, formation of cell surface protrusions, antioxidant response, and IL-6 and TGF-beta1 secretion, while in LPS-activated fibroblasts, O3 stimulated only antioxidant response and cytokines secretion. o2-o3 22-27 interleukin 6 Homo sapiens 243-247 34127514-6 2021 Compared with the non-IPA group, the proven/probable IPA group showed significantly elevated levels of IL-6 and IL-8 in both serum and BALF, which were positively correlated with galactomannan levels. galactomannan 179-192 interleukin 6 Homo sapiens 103-107 34638824-8 2021 Of note, fractions obtained from blackberry juice, in particular cyanidin-3O-(6""-dioxalylglucoside), were displaying potential pro-inflammatory properties as these elevated IL-6 and TNF-alpha levels. cyanidin-3o-(6""-dioxalylglucoside 65-99 interleukin 6 Homo sapiens 174-178 19450686-0 2009 Circulating levels of advanced glycation end products (AGE) and interleukin-6 (IL-6) are independent determinants of serum asymmetric dimethylarginine (ADMA) levels in patients with septic shock. dimethylarginine 134-150 interleukin 6 Homo sapiens 64-77 34561306-6 2021 While monophosphoryl lipid A synthetic, a TLR4 ligand, induced checkpoint inhibitors indicative for immune exhaustion, the TLR7/8 agonist Resiquimod (R848) induced prominent type-1 interferon and interleukin 6 responses and robust CTL, B-cell, and NK-cell proliferation, which is particularly suited for antiviral immune responses. resiquimod 138-148 interleukin 6 Homo sapiens 196-209 34409634-11 2022 CONCLUSIONS: Colchicine reduced cardiovascular events and inflammatory markers, hs-CRP and IL-6, in patients with coronary disease compared to controls. Colchicine 13-23 interleukin 6 Homo sapiens 91-95 34804428-15 2021 SB203580, PDTC, and alpha-LA reversed the effects of chemerin, reducing IL-6, TNF-alpha, NF-kappaB p-p65, and TGF-beta expression. prolinedithiocarbamate 10-14 interleukin 6 Homo sapiens 72-76 34126229-10 2021 Summarizing earlier studies, we demonstrated that circulating concentrations of inflammatory cytokines such as CRP, TNF-alpha, and IL-6 might be decreased following vitamin D supplementation among individuals with AGH. agh 214-217 interleukin 6 Homo sapiens 131-135 34544906-6 2021 Moreover, norbixin reduces protein kinase B (AKT) phosphorylation, NF-kappaB and AP-1 transactivation and mRNA expression of the inflammatory interleukins (IL) -6 and -8 and of vascular endothelial growth factor (VEGF) enhanced by A2E. norbixin 10-18 interleukin 6 Homo sapiens 142-169 34389624-0 2021 Differential Regulation of ATP- and UTP-Evoked Prostaglandin E2 and IL-6 Production from Human Airway Epithelial Cells. Uridine Triphosphate 36-39 interleukin 6 Homo sapiens 68-72 19450686-0 2009 Circulating levels of advanced glycation end products (AGE) and interleukin-6 (IL-6) are independent determinants of serum asymmetric dimethylarginine (ADMA) levels in patients with septic shock. dimethylarginine 134-150 interleukin 6 Homo sapiens 79-83 34439789-6 2021 Significant correlations were found with PHE volume for IL-6, IL-10 and CCL2 at day 1-2 and with relative PHE at days 7-8 or 9-10 for IL-1beta, IL-6, IL-8, and IL-10. Phenylalanine 41-44 interleukin 6 Homo sapiens 56-60 34439789-6 2021 Significant correlations were found with PHE volume for IL-6, IL-10 and CCL2 at day 1-2 and with relative PHE at days 7-8 or 9-10 for IL-1beta, IL-6, IL-8, and IL-10. Phenylalanine 106-109 interleukin 6 Homo sapiens 144-148 19450686-0 2009 Circulating levels of advanced glycation end products (AGE) and interleukin-6 (IL-6) are independent determinants of serum asymmetric dimethylarginine (ADMA) levels in patients with septic shock. N,N-dimethylarginine 152-156 interleukin 6 Homo sapiens 64-77 19450686-0 2009 Circulating levels of advanced glycation end products (AGE) and interleukin-6 (IL-6) are independent determinants of serum asymmetric dimethylarginine (ADMA) levels in patients with septic shock. N,N-dimethylarginine 152-156 interleukin 6 Homo sapiens 79-83 34803441-8 2021 Currently corticosteroids, IL-6 blockers, or IL-1 blockers are most widely used for treating COVID-CS. covid-cs 93-101 interleukin 6 Homo sapiens 27-31 19450686-12 2009 The present study is the first demonstration that ADMA levels were significantly elevated in patients with septic shock and that serum IL-6, AGE and creatinine levels were independent determinants of ADMA in these patients. N,N-dimethylarginine 200-204 interleukin 6 Homo sapiens 135-139 19860911-11 2009 CONCLUSION: Genetic variants of proinflammatory cytokines TNF-alpha and IL-6 confer susceptibility to severe OL. ol 109-111 interleukin 6 Homo sapiens 72-76 34415898-9 2021 Overall, IL-4 levels did not change significantly over time in either group; however, patients within the CE3b group showed a significant decrease of IL-1ra, IL-6, IL-8, G-CSF, IFN-gamma, IP-10, MCP-1, MIP-1alpha, FGF at T1 compared to T0 (p<=0.042). ce3b 106-110 interleukin 6 Homo sapiens 158-162 34280220-3 2021 TG6-44 significantly decreased A/X31-induced ROS and virus-induced inflammatory mediators in THP-1 cells (IL-6, IFN-gamma, MCP-1, TNF-alpha, MIP-1beta) and in human PBMC (IL-6, IL-8, TNF-alpha, MCP-1). 6-O-phosphono-D-tagatose 0-3 interleukin 6 Homo sapiens 106-110 34280220-3 2021 TG6-44 significantly decreased A/X31-induced ROS and virus-induced inflammatory mediators in THP-1 cells (IL-6, IFN-gamma, MCP-1, TNF-alpha, MIP-1beta) and in human PBMC (IL-6, IL-8, TNF-alpha, MCP-1). 6-O-phosphono-D-tagatose 0-3 interleukin 6 Homo sapiens 171-175 34350063-4 2021 Alternol triggered ICD in prostate cancer cells, as evidenced by the release of damage-associated molecular patterns (DAMPs) (i.e., calreticulin, CALR; high mobility group protein B1, HMGB1; and adenosine triphosphate, ATP) and pro-inflammatory cytokine (i.e., interleukin (IL)-1alpha, IL-1beta, IL-6, and IL-8) expression. Alternol 0-8 interleukin 6 Homo sapiens 296-300 19723085-6 2009 We found that omega-3 fatty acids, such as docosahexaenoic acid (DHA) and alpha-linolenic acid (ALA), suppressed the expression of inflammatory cytokines (IL-1beta, IL-6) and inhibited the activation of transcription factor activator protein-1 in cerulein-stimulated pancreatic acinar cells. Docosahexaenoic Acids 43-63 interleukin 6 Homo sapiens 165-169 34284852-5 2021 During 3-6 months of treatment, compared with baseline, the PEG-IFN group showed a significant decrease in interferon-gamma (IFN-gamma), interleukin-17A (IL-17A), interleukin-6(IL-6), interleukin-10(IL-10), and transforming growth factor beta (TGF-beta) ( P < 0.001) and a significant increase in interferon-alpha 2(IFN-alpha2) ( P < 0.001). peg-ifn 60-67 interleukin 6 Homo sapiens 163-176 34284852-5 2021 During 3-6 months of treatment, compared with baseline, the PEG-IFN group showed a significant decrease in interferon-gamma (IFN-gamma), interleukin-17A (IL-17A), interleukin-6(IL-6), interleukin-10(IL-10), and transforming growth factor beta (TGF-beta) ( P < 0.001) and a significant increase in interferon-alpha 2(IFN-alpha2) ( P < 0.001). peg-ifn 60-67 interleukin 6 Homo sapiens 177-181 19723085-6 2009 We found that omega-3 fatty acids, such as docosahexaenoic acid (DHA) and alpha-linolenic acid (ALA), suppressed the expression of inflammatory cytokines (IL-1beta, IL-6) and inhibited the activation of transcription factor activator protein-1 in cerulein-stimulated pancreatic acinar cells. Docosahexaenoic Acids 65-68 interleukin 6 Homo sapiens 165-169 34185243-0 2021 The IL-6/STAT Signaling Pathway and PPARalpha Are Involved in Mediating the Dose-Dependent Cardioprotective Effects of Fenofibrate in 5-Fluorouracil-Induced Cardiotoxicity. Fenofibrate 119-130 interleukin 6 Homo sapiens 4-8 19145631-5 2009 Silicone induced production of TNF-alpha and IL-6 in all three groups. Silicones 0-8 interleukin 6 Homo sapiens 45-49 34185243-9 2021 FEN reversed 5FU-induced cardiotoxicity by various mechanisms including upregulation of PPARalpha, inhibition of the IL-6/STAT signaling pathway, and anti-inflammatory, antiapoptotic, and antioxidant properties. Fenofibrate 0-3 interleukin 6 Homo sapiens 117-121 34497749-13 2021 Quercetin and Luteolin were verified to have good binding capability with the hub potential targets IL6, MAPK1, AKT1 through molecular docking. Luteolin 14-22 interleukin 6 Homo sapiens 100-103 34140036-11 2021 Anti-miR-337-3p or ADAMTS5 overexpression correspondingly reversed si-circ-SPG11 or miR-337-3p overexpression-mediated facilitation in viability, and inhibition in apoptosis, TNF-alpha and IL-6 generation and ECM degradation in OA model cells. mir-337-3p 5-15 interleukin 6 Homo sapiens 189-193 34140036-11 2021 Anti-miR-337-3p or ADAMTS5 overexpression correspondingly reversed si-circ-SPG11 or miR-337-3p overexpression-mediated facilitation in viability, and inhibition in apoptosis, TNF-alpha and IL-6 generation and ECM degradation in OA model cells. mir-337-3p 84-94 interleukin 6 Homo sapiens 189-193 19145631-6 2009 Notably, elevated production of IL-6 was observed in nonstimulated PBMC and also the percentage of CD4(+)CD69(+) T cells was higher in PHA-stimulated PBMC from individuals with silicone injection-related adverse reactions when compared with other two groups. Silicones 177-185 interleukin 6 Homo sapiens 32-36 34211989-8 2021 HIV+ children presented significantly higher levels of seven biomarkers (CD14, IL-6 HVEM, B7.1, Siglec-10, HIF-1alpha, and CD163) than the UU group. UU 139-141 interleukin 6 Homo sapiens 79-83 19385035-3 2009 The present study was undertaken using the established co-culture system of Caco-2 epithelial cells with lymphocytes of Peyer"s patch to investigate the expression of IL-8 and IL-6 cytokines and cytokine receptors in the co-culture system after challenge with Shigella F2a-12 lipopolysaccharide (LPS). 12 lipopolysaccharide 273-294 interleukin 6 Homo sapiens 176-180 34200459-12 2021 In conclusion, high plasma HGF, CXCL11, CXCL10 and IL-6 levels are associated with worse outcome in mRCC patients treated with sunitinib or pazopanib. Sunitinib 127-136 interleukin 6 Homo sapiens 51-55 34133348-11 2021 CONCLUSION: EDA can significantly reduce the serum concentrations of CXCL13 and IL-6 and improve the PND of patients. Edaravone 12-15 interleukin 6 Homo sapiens 80-84 34221235-8 2021 Pretreatment with SS-31 normalized TNF-alpha, IL-6, and MMP9 expression, MDA and SOD activities, and ROS generation in CSE-treated BEAS-2B cells and reversed the changes in MFF and OPA1 expression. arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide 18-23 interleukin 6 Homo sapiens 46-50 34149863-13 2021 SCDP key active ingredients are mainly quercetin, wogonin, baicalein, acacetin, oroxylin A, and beta-sitosterol, which function mainly by regulating targets, such as PTGS2, CASP3, TP53, IL-6, TNF, and AKT1, and are associated with multiple signaling pathways as pathways in cancer, PI3K-Akt signaling pathway, apoptosis, IL-17 signaling pathways. scdp 0-4 interleukin 6 Homo sapiens 186-190 34122007-9 2021 Meanwhile, VPA reduced dMCAo-induced elevation of IL-6 at 24 h post-stroke and significantly decreased the number of CD11b-positive microglia within peri-infarct cortex at 7 days. dmcao 23-28 interleukin 6 Homo sapiens 50-54 34077680-4 2021 ZMO exhibited anti-inflammatory capacity by inhibiting the formation of pro-inflammatory markers such as nitric oxide, inducible nitric oxide synthase, cyclooxygenase-2, interleukin (IL)-1beta, IL-6, and monocyte chemoattractant protein-1 in LPS-treated macrophages. S-[2-({n-[(2s)-2-Hydroxy-3,3-Dimethyl-4-(Phosphonooxy)butanoyl]-Beta-Alanyl}amino)ethyl] (9z)-Hexadec-9-Enethioate 0-3 interleukin 6 Homo sapiens 194-198 19171135-6 2009 Endothelin-1-induced IL-6 production was markedly attenuated by EGTA and various Ca(2+) channel inhibitors such as 3,5-bis(trifluoromethyl)-1H-pyrazole derivative (BTP-2), 1-[beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole hydrochloride (SKF96365), and nifedipine. 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole 257-265 interleukin 6 Homo sapiens 21-25 34234397-0 2021 Molecular docking analysis of stachydrine and sakuranetin with IL-6 and TNF-alpha in the context of inflammation. stachydrine 30-41 interleukin 6 Homo sapiens 63-67 34234397-2 2021 Therefore, it is of interest to document the anti-inflammatory activity of Stachydrine and Sakuranetin against the inflammatory target proteins IL-6 and TNF-alpha by using molecular docking analysis. stachydrine 75-86 interleukin 6 Homo sapiens 144-148 34234397-5 2021 Hence, data show that Stachydrine possessed high and specific inhibitory activity on tumor necrosis factor-alpha and interleukin-6. stachydrine 22-33 interleukin 6 Homo sapiens 117-130 34064830-6 2021 alpha-Humulene also reduced the expression levels of cytokine genes such as interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF) by downregulating nuclear factor-kappaB (NF-kappaB) nuclear translocation. humulene 0-14 interleukin 6 Homo sapiens 100-104 35452830-12 2022 CONCLUSION: CRRT with topical citrate + low-dose LMW heparin-calcium anticoagulation in the treatment of patients with SAP reduces the levels of WBC, CRP, and PCT and the concentrations of cytokines, including IL-6, IL-8, and TNF-alpha. Citric Acid 30-37 interleukin 6 Homo sapiens 210-214 19171135-6 2009 Endothelin-1-induced IL-6 production was markedly attenuated by EGTA and various Ca(2+) channel inhibitors such as 3,5-bis(trifluoromethyl)-1H-pyrazole derivative (BTP-2), 1-[beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole hydrochloride (SKF96365), and nifedipine. Nifedipine 272-282 interleukin 6 Homo sapiens 21-25 35440370-6 2022 The addition of amoxicillin to clarithromycin resulted in an increase in CD8+ IL-6 (p = 0.010), decrease in CD8+ (p = 0.014) and CD4+ (p = 0.022) TNF-alpha, and decrease in CD8+ IFN-alpha (p = 0.038). Clarithromycin 31-45 interleukin 6 Homo sapiens 78-82 19074641-6 2009 Curcumin, as well as inhibitors of NF-kappaB (SN-50), PKC (chelerythrine), and p44/42 MAPK (PD-098059) abolished the acid-induced expression of IL-6 and IL-8. chelerythrine 59-72 interleukin 6 Homo sapiens 144-148 35129804-6 2022 The supernatant levels of TNF-alpha, IL-1beta, and IL-6 in the high-dosage ginkgolide-treated groups were lower than those in the control group. Ginkgolides 75-85 interleukin 6 Homo sapiens 51-55 35288272-12 2022 Significantly higher serum levels of interleukin-6 were observed during the acute reactions to polysulfone hemodialysis. polysulfone P 1700 95-106 interleukin 6 Homo sapiens 37-50 35574720-8 2022 Kaempferol down-regulated the mRNA expression levels of TNF-alpha, IL-6, and CCL2 in oxaliplatin-treated astrocytes. Oxaliplatin 85-96 interleukin 6 Homo sapiens 67-71 19411809-6 2009 However, a trend towards a dose-dependent biphasic effect was observed for IL- 6, IL-10 and MCP-1 with reduced immune mediator levels at low and increased/unaltered levels at higher somatostatin or octreotide concentrations. Octreotide 198-208 interleukin 6 Homo sapiens 75-80 35628136-0 2022 Novel Benzoxazoles Containing 4-Amino-Butanamide Moiety Inhibited LPS-Induced Inflammation by Modulating IL-6 or IL-1beta mRNA Expression. Benzoxazoles 6-18 interleukin 6 Homo sapiens 105-109 35623869-11 2022 l-Carnitine supplementation significantly reduced the levels of CRP (mean change +- SE: -34.9 +- 6.5) and IL-6 (mean change +- SE: -10.64 +- 2.16) compared to the baseline, which is both statistically significant compared with the control group (p < 0.05). Carnitine 0-11 interleukin 6 Homo sapiens 106-110 35573706-5 2022 Blocking HA synthesis and accumulation with 4-methylumbelliferone reduced expression of IL6, IL1beta, and TNF in both OA FLS and RA FLS co-cultures. Hymecromone 44-65 interleukin 6 Homo sapiens 88-91 19229322-5 2009 Our present findings demonstrate a rapid and HMB-PP-dependent crosstalk between Vgamma9/Vdelta2 T cells and autologous monocytes that results in the immediate production of inflammatory mediators including the cytokines interleukin (IL)-6, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, and oncostatin M (OSM); the chemokines CCL2, CXCL8, and CXCL10; and TNF-related apoptosis-inducing ligand (TRAIL). 4-hydroxy-3-methylbut-2-enyl pyrophosphate 45-51 interleukin 6 Homo sapiens 220-238 35395844-7 2022 RESULTS: The levels of serum tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, IL-8, and macrophage inflammatory protein (MIP)-1alpha were elevated in patients with CTEPH. cteph 176-181 interleukin 6 Homo sapiens 70-88 35625428-6 2022 The data showed that farnesol-loaded SUVs reduced FFA-induced IL6 and LIF expression by 77% and 70% in SkMs, respectively. Farnesol 21-29 interleukin 6 Homo sapiens 62-65 35625428-7 2022 Farnesol-loaded MLVs were less potent in inhibiting FFA-induced IL6 and LIF expression. Farnesol 0-8 interleukin 6 Homo sapiens 64-67 18421458-7 2009 Stimulation with BCG led to increased levels of TNF and IL-6 during the LP period compared to control (P = 0.001; P = 0.04, respectively). leucylproline 72-74 interleukin 6 Homo sapiens 56-60 35467090-0 2022 Platelet sTWEAK and plasma IL-6 are associated with 18F-fluorodeoxyglucose uptake in right ventricles of patients with pulmonary arterial hypertension: A pilot study. Fluorodeoxyglucose F18 52-74 interleukin 6 Homo sapiens 27-31 35453772-9 2022 CONCLUSIONS: curcumin and piperine supplementation had no effect on physical performance, immune cell counts, or muscle damage; however, the supplementation could modulate the kinetics of IL-2, TNF-alpha, INF, IL-6, and IL-10 1 h after the end of exercise. piperine 26-34 interleukin 6 Homo sapiens 210-214 35442463-17 2022 CONCLUSIONS: (1) Icariin, quercetin and luteolin may act on target proteins, including IL-6, ESR1, EGFR, MAPK8, VEGFA and CASP8, to participate in the regulation of the human cytomegalovirus infection pathway, the PI3K-Akt signaling pathway, the TNF signaling pathway and other signaling pathways in order to effectively treat CAD. Luteolin 40-48 interleukin 6 Homo sapiens 87-91 35368876-10 2022 Our results indicated that PEITC decreased the cell viability and inhibited the protein levels and expressions of IL-1beta, IL-6, and TNF-alpha genes at the transcriptional level in GBM 8401 cells. phenethyl isothiocyanate 27-32 interleukin 6 Homo sapiens 124-128 19091984-0 2008 Interleukin-6 mediates the increase in NADPH-oxidase in the ketamine model of schizophrenia. Ketamine 60-68 interleukin 6 Homo sapiens 0-13 35310053-6 2022 RESULTS: Corneal fibroblasts exposed to polyI:C demonstrated decreased VCAM-1, ICAM-1, MCP-1, IL-6, and IL-8 expression levels upon exposure to LUT in a time-dependent and concentration-dependent manner. Luteolin 144-147 interleukin 6 Homo sapiens 94-98 35264090-6 2022 IL-6 increases GLUT-4 vesicle mobilization to muscle cell periphery, increasing the glucose transport into the cell, and also glycogen synthesis. Glycogen 126-134 interleukin 6 Homo sapiens 0-4 35204178-5 2022 Improved antioxidant capacity of O-EGCG was observed, and there was a significant decrease in the inflammatory markers (IL-1beta, IL-6, and TNF-alpha) when O-EGCG was applied as compared to EGCG. o-egcg 156-162 interleukin 6 Homo sapiens 130-134 35205631-6 2022 Next, we measured baseline plasma IL-6 levels in 64 HCC patients who underwent Atezo/Bev therapy by ELISA. atezo/bev 79-88 interleukin 6 Homo sapiens 34-38 35041974-9 2022 The pretreatment with carvacrol significantly reduced viral shedding titer, chIFITM3 gene expression, IL-6 and alpha1-AGP levels, leucocytic response and H/L ratio with minimization of clinical signs intensity. carvacrol 22-31 interleukin 6 Homo sapiens 102-106 34988564-8 2022 The postprandial level of pro-inflammatory cytokines (IL-1beta, IL-6 and TNF-alpha) significantly increased at 3 h and 6 h after the HCMF meal intake when compared to the fasting state. hcmf 133-137 interleukin 6 Homo sapiens 64-68 19091984-3 2008 Here we show that neuronal production of interleukin-6 (IL-6) is necessary and sufficient for ketamine-mediated activation of NADPH-oxidase in brain. Ketamine 94-102 interleukin 6 Homo sapiens 41-54 35057010-7 2022 Luteolin and rutin inhibit NFkappaB activation, reducing IL-6 production. Luteolin 0-8 interleukin 6 Homo sapiens 57-61 35204178-6 2022 The O-EGCG was shown to be strongly associated with the highest docking score and active site residues of IL-1, IL-6, and TNF- alpha, as well as the Mpro of SARS-CoV-2, according to in silico approach. o-egcg 4-10 interleukin 6 Homo sapiens 112-116 19091984-3 2008 Here we show that neuronal production of interleukin-6 (IL-6) is necessary and sufficient for ketamine-mediated activation of NADPH-oxidase in brain. Ketamine 94-102 interleukin 6 Homo sapiens 56-60 19091984-6 2008 Our results showing that ketamine-induced IL-6 is responsible for the activation of NADPH-oxidase in brain suggest that reducing brain levels of this cytokine may protect the GABAergic phenotype of fast-spiking PV-interneurons and thus attenuate the propsychotic effects of ketamine. Ketamine 25-33 interleukin 6 Homo sapiens 42-46 19091984-6 2008 Our results showing that ketamine-induced IL-6 is responsible for the activation of NADPH-oxidase in brain suggest that reducing brain levels of this cytokine may protect the GABAergic phenotype of fast-spiking PV-interneurons and thus attenuate the propsychotic effects of ketamine. Ketamine 274-282 interleukin 6 Homo sapiens 42-46 35048417-6 2022 Analysis of cell culture medium of rifampicin treated HS explants revealed an anti-inflammatory effect of rifampicin that significantly inhibiting interleukin (IL)-1beta, IL-6, IL-8, IL-10, and tumour necrosis factor (TNF) -alpha production. Rifampin 35-45 interleukin 6 Homo sapiens 171-175 35048417-6 2022 Analysis of cell culture medium of rifampicin treated HS explants revealed an anti-inflammatory effect of rifampicin that significantly inhibiting interleukin (IL)-1beta, IL-6, IL-8, IL-10, and tumour necrosis factor (TNF) -alpha production. Rifampin 106-116 interleukin 6 Homo sapiens 171-175 18975348-9 2008 In vitro, treatment with fasudil or Y27632 decreased production of tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and IL-6 by synovial membrane cells, peripheral blood mononuclear cells, and fibroblast-like synoviocytes from patients with active RA. fasudil 25-32 interleukin 6 Homo sapiens 141-145 19034873-9 2008 LY294002, NH4Cl, CAPE, PD098059 and SB202190 all reduced albumin-mediated IL-6 release, but neither PDTC nor MG132 had any effect. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 36-44 interleukin 6 Homo sapiens 74-78 18631349-9 2008 High concentrations of muramic acid in floor dust were related to increased production of TNF-alpha and IL-6 at the age of 3 months. Muramic Acids 23-35 interleukin 6 Homo sapiens 104-108 35111001-4 2021 In addition, elamipretide has been shown to attenuate neural oxidative stress (hydrogen peroxide, lipid peroxidation, and ROS), neuroinflammation (TNF, IL-6, COX-2, iNOS, NLRP3, cleaved caspase-1, IL-1beta, and IL-18), and toxic protein accumulation (Abeta). arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide 13-25 interleukin 6 Homo sapiens 152-156 18768046-10 2008 RESULTS: The methylprednisolone group had higher partial pressure of oxygen (P = 0.01), lower plasma levels of TNF-alpha (P = 0.03) and IL-6 (P = 0.001) when compared with control group. Methylprednisolone 13-31 interleukin 6 Homo sapiens 136-140 19016005-6 2008 In conclusion, these results suggested that chronic high dose of IL-6 directly stimulated lipolysis in porcine adipocytes through activation of ERK, subsequently repressing perilipin A and promoting PGC-1alpha expression. perilipin a 173-184 interleukin 6 Homo sapiens 65-69 18040689-0 2008 Suppression of human macrophage interleukin-6 by a nonpsychoactive cannabinoid acid. cannabinoid acid 67-83 interleukin 6 Homo sapiens 32-45 18164123-3 2008 1-BP dose-dependently induced the production of NO and proinflammatory cytokines, such as IL-1beta, IL-6, and TNF-alpha, and expression levels of these genes also increased in a dose-dependent manner. 1-bromopropane 0-4 interleukin 6 Homo sapiens 100-104 18464882-0 2008 Preoperative oral administration of pentoxifylline ameliorates respiratory index after cardiopulmonary bypass through decreased production of IL-6. Pentoxifylline 36-50 interleukin 6 Homo sapiens 142-146 17609220-5 2008 A decrease in ACTH and DHEA (p<0.01) was observed with GC during all of the experiments and in IL-6 after exhaustion (p<0.05). Dehydroepiandrosterone 23-27 interleukin 6 Homo sapiens 98-102 18557135-7 2008 We here show that exposure to IL-1 and IL-6 significantly increased the levels of DCF-detectable ROS in cells cultured in physiologic concentrations of Mg, but not in Mg-deprived cells. Magnesium 152-154 interleukin 6 Homo sapiens 39-43 18195163-13 2008 Our data suggest that fetally derived trophoblasts require direct cell-cell contact with maternally derived VSMCs to downregulate VSMC C3 and interleukin-6 expression and to avoid atherosis. vsmcs 108-113 interleukin 6 Homo sapiens 142-155 18252009-7 2008 RESULTS: RU inhibited inflammation-related gene expression in activated human macrophages and the release of nitric oxide, tumor necrosis factor-alpha, interleukin (IL)-1, and IL-6 from these cells. Rutin 9-11 interleukin 6 Homo sapiens 176-180 17720876-9 2007 However, the PKCepsilon inhibitor, Ro 31-8220, effectively inhibited FLDE-stimulated IL-8 and IL-6 release. flde 69-73 interleukin 6 Homo sapiens 94-98 17720876-10 2007 Inhibition of FLDE-stimulated IL-6 and IL-8 was confirmed in a dominant-negative PKCepsilon-expressing BEAS-2B cell line but not observed in a PKCalpha dominant negative BEAS-2B cell line. flde 14-18 interleukin 6 Homo sapiens 30-34 17720876-11 2007 These data support the hypothesis that FLDE exposure stimulates bronchial epithelial IL-8 and IL-6 release via a PKCepsilon-dependent pathway. flde 39-43 interleukin 6 Homo sapiens 94-98 17988365-4 2007 RESULTS: Monocytes stimulated by LPS from non-lithium-treated bipolar patients were characterized by an abnormal IL-1beta/IL-6 production ratio, i.e., low IL-1beta and high IL-6 production. Lithium 46-53 interleukin 6 Homo sapiens 122-126 17988365-4 2007 RESULTS: Monocytes stimulated by LPS from non-lithium-treated bipolar patients were characterized by an abnormal IL-1beta/IL-6 production ratio, i.e., low IL-1beta and high IL-6 production. Lithium 46-53 interleukin 6 Homo sapiens 173-177 17988365-5 2007 Lithium treatment increased IL-1beta and decreased IL-6 production and thus restored the aberrant ratio. Lithium 0-7 interleukin 6 Homo sapiens 51-55 17581928-6 2007 In addition, genistein and herbimycin A completely blocked the IL-6-induced increases in alpha-MG uptake and the protein expression level of SGLTs. herbimycin 27-39 interleukin 6 Homo sapiens 63-67 17581928-7 2007 On the other hand, IL-6 increased the level of 5-(and-6)-chloromethyl-2",7"-dichlorodihydrofluorescein diacetate-sensitive cellular reactive oxygen species (ROS), and IL-6-induced increases in alpha-MG uptake and the protein expression level of SGLTs were blocked by ascorbic acid or taurine (antioxidants). 2',7'-dichlorodihydrofluorescein diacetate 69-112 interleukin 6 Homo sapiens 19-23 17957548-8 2007 Both HP and LP CAPs stimulated the release of proinflammatory cytokines tumor necrosis factor (TNF) alpha and interleukin (IL)-6 after 6 h of exposures. leucylproline 12-14 interleukin 6 Homo sapiens 110-128 17590218-10 2007 Celecoxib, on the other hand, did not change the concentrations of SP and significantly reduced the levels of IL-6 only on day 14. Celecoxib 0-9 interleukin 6 Homo sapiens 110-114 17289797-4 2007 We found that treatment with the H2S donor, sodium hydrosulfide, led to significant increases in the mRNA expression and protein production of TNF-alpha, IL-1beta, and IL-6 in U937 cells. Hydrogen Sulfide 33-36 interleukin 6 Homo sapiens 168-172 17289797-7 2007 Furthermore, pretreatment of cells with Bay 11-7082 substantially inhibited the secretion of TNF-alpha, IL-1beta, and IL-6 induced by H2S. Hydrogen Sulfide 134-137 interleukin 6 Homo sapiens 118-122 17204543-10 2007 DFO stimulation resulted in a significant increase in epithelial cell IL-6 and VEGF production while yielding a decrease in HGF production (P<0.05). Deferoxamine 0-3 interleukin 6 Homo sapiens 70-74 17204543-13 2007 In conclusion, DFO acutely increases fetal human intestinal epithelial cell IL-6 and VEGF expression while causing an unexpected decrease in HGF expression and no detectable TNF-alpha production. Deferoxamine 15-18 interleukin 6 Homo sapiens 76-80 16781858-5 2007 Both EPA and DHA reduced TNF-alpha, IL-1beta and IL-6 mRNA expression. Docosahexaenoic Acids 13-16 interleukin 6 Homo sapiens 49-53 16781858-7 2007 Furthermore, a low dose (25 microM) of DHA had a greater inhibitory effect than that of EPA on macrophage IL-1beta (P<.01 and P<.04, respectively) and IL-6 (P<.003 and P<.003, respectively) production following 0.01 and 0.1 microg/ml LPS stimulation. Docosahexaenoic Acids 39-42 interleukin 6 Homo sapiens 157-161 17374166-0 2007 The Interleukin-6 inflammation pathway from cholesterol to aging--role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases. Polyphenols 109-120 interleukin 6 Homo sapiens 4-17 17360885-1 2007 Low levels of dehydroepiandrosterone (DHEA) and cortisol hormones produced by the suprarenal cortex have been associated with diseases involving chronic inflammation, low interferon (IFN)-gamma, and high interleukin (IL)-6. Dehydroepiandrosterone 14-36 interleukin 6 Homo sapiens 204-222 17360885-1 2007 Low levels of dehydroepiandrosterone (DHEA) and cortisol hormones produced by the suprarenal cortex have been associated with diseases involving chronic inflammation, low interferon (IFN)-gamma, and high interleukin (IL)-6. Dehydroepiandrosterone 38-42 interleukin 6 Homo sapiens 204-222 16784898-11 2007 Potential mechanisms of DHEA action, including the biotransformation of DHEA to active steroids and steroid metabolites, enhancement of IGF-I bioavailability, and inhibition of IL-6 production can also be evaluated. Dehydroepiandrosterone 24-28 interleukin 6 Homo sapiens 177-181 17469457-3 2007 AIM: We hypothesized that ketoprofen would affect release of IL-6 and IL-10 and modulate the immune response. Ketoprofen 26-36 interleukin 6 Homo sapiens 61-65 18997280-5 2007 Here, we report that after differentiating THP-1 cells to macrophages, ritonavir treatment (10 microg/mL) significantly increases expression of proinflammatory cytokines, IL-6, MCP-1 and IL-8, at both mRNA and protein levels. Ritonavir 71-80 interleukin 6 Homo sapiens 171-175 17713325-0 2007 Effects of levofloxacin and doxycycline on interleukin-6 production of Chlamydia trachomatis-infected human synovial fibroblasts. Doxycycline 28-39 interleukin 6 Homo sapiens 43-56 17713325-6 2007 RESULTS: The production of IL-6 was suppressed to as low as 1,800 pg/ml in the infected HFLS treated with levofloxacin or doxycycline immediately or early after infection. Doxycycline 122-133 interleukin 6 Homo sapiens 27-31 17713325-7 2007 In HFLS treated with levofloxacin and doxycycline, the IL-6 levels decreased to 37,000 and 21,000 pg/ml, respectively, 48 h after infection, and levofloxacin was thus found to be less effective than doxycycline. Doxycycline 38-49 interleukin 6 Homo sapiens 55-59 17673806-4 2007 [Melanoma Res 2006;16:263-265] of remission of an advanced melanoma during treatment with the cyclooxygenase, (COX) inhibitor rofecoxib can be explained by rofcoxib-mediated lowering of tumor-produced Il-6. rofcoxib 156-164 interleukin 6 Homo sapiens 201-205 16940328-4 2006 The TREM-1/NLR synergism was observed for the production of TNF-alpha, IL-1beta, and IL-6, leading to an increase in cytokine production up to tenfold greater than the additive value of TREM-1 or muropeptide stimulation alone. muropeptide 196-207 interleukin 6 Homo sapiens 85-89 17130674-5 2006 2-APB [(2-aminoethoxy)diphenylborane], an inositol 1,4,5-trisphosphate (IP(3))-receptor antagonist, inhibited UTP-induced IL-6 mRNA expression; and the action of A23187, a Ca(2+) ionophore, resembled the action of UTP. Inositol 42-50 interleukin 6 Homo sapiens 122-126 16896785-1 2006 OBJECTIVE: The objective of this study was to assess the effect of amlodipine-atorvastatin combination on plasma interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and insulin sensitivity in normocholesterolemic obese hypertensive patients. Amlodipine 67-77 interleukin 6 Homo sapiens 113-126 18172961-12 2006 CONCLUSION: It can be concluded that pentoxifylline can prevent further degradation of nitrogen in patients suffering from phlegmona of the foot, decreasing the catabolic effect of infection, most probably by inhibiting the effect of TNF-alpha, interleukin-1 and interleukin-6, without any significant effect on leukocytosis during four days of treatment. Pentoxifylline 37-51 interleukin 6 Homo sapiens 263-276 16983050-8 2006 CONCLUSIONS: Morning sIL-6R levels demonstrated stronger associations with moderate to severe SRBD than morning IL-6 levels. srbd 94-98 interleukin 6 Homo sapiens 22-26 17064581-9 2006 HCY of different concentration of 0.25 mmol/L increased the protein expression of TNF-alpha, IL-6, MCP-1, and ICAM-1 significantly; however, the expression levels of TNF-alpha, IL-6, MCP-1, and ICAM-1 of the 0.25 mmol/L HCY-treated HUVECs that were pretreated by SIM of the concentration of 10 micromol/L for 1 hour were, 0.23 +/- 0.05, 0.14 +/- 0.03, 0.13 +/- 0.04, and 0.21 +/- 0.07 respectively, not significantly different from those at the time of 0 hour (all P > 0.05). Homocysteine 0-3 interleukin 6 Homo sapiens 93-97 17064581-9 2006 HCY of different concentration of 0.25 mmol/L increased the protein expression of TNF-alpha, IL-6, MCP-1, and ICAM-1 significantly; however, the expression levels of TNF-alpha, IL-6, MCP-1, and ICAM-1 of the 0.25 mmol/L HCY-treated HUVECs that were pretreated by SIM of the concentration of 10 micromol/L for 1 hour were, 0.23 +/- 0.05, 0.14 +/- 0.03, 0.13 +/- 0.04, and 0.21 +/- 0.07 respectively, not significantly different from those at the time of 0 hour (all P > 0.05). Homocysteine 0-3 interleukin 6 Homo sapiens 177-181 16775727-3 2006 Experimental and clinical studies have shown that ketamine exerts antiinflammatory properties by inhibiting the release of proinflammatory cytokines, such as tumor necrosis factor-alpha and interleukin-6. Ketamine 50-58 interleukin 6 Homo sapiens 190-203 16956428-7 2006 Hcy enhanced IL-6 and IL-8 production in RA synoviocytes only (up to 35%). Homocysteine 0-3 interleukin 6 Homo sapiens 13-17 16418198-11 2006 Weak-base amines such as methylamine and ammonium chloride had no effect on the production of TNF-alpha, whereas they partially blocked the production of IL-1beta and IL-6. weak-base amines 0-16 interleukin 6 Homo sapiens 167-171 16833194-5 2006 Calphostin C, one inhibitor of the protein kinase C (PKC), could block IL-6-induced AR in human sperm. calphostin C 0-12 interleukin 6 Homo sapiens 71-75 16381797-5 2006 Inhibitors of IP(3)-dependent Ca(2+) signals, like 2-aminoethoxydiphenyl borate (2-APB) and U-73122, decreased activation of IL-6 gene expression as did Ca(2+) signals inhibitor BAPTA-AM, whereas ryanodine, a fast Ca(2+) transient inhibitor, had no effect on IL-6 induction. Ryanodine 196-205 interleukin 6 Homo sapiens 125-129 16381797-6 2006 Depolarization of myotubes transiently transfected with a reporter gene construct, containing 651 bp of IL-6 promoter, induced a twofold increase in promoter activity, which was abolished by either 2-APB or U-73122 and remained unaffected after ryanodine treatment. Ryanodine 245-254 interleukin 6 Homo sapiens 104-108 16384608-1 2006 Three different protocols were carried out to evaluate the effect of magnesium sulfate (MgSO4) on the capacity of the normal human placenta to secrete TNF-alpha and IL-6 in presence and absence of angiotensin II (AII). Magnesium Sulfate 69-86 interleukin 6 Homo sapiens 165-169 16384608-1 2006 Three different protocols were carried out to evaluate the effect of magnesium sulfate (MgSO4) on the capacity of the normal human placenta to secrete TNF-alpha and IL-6 in presence and absence of angiotensin II (AII). Magnesium Sulfate 88-93 interleukin 6 Homo sapiens 165-169 16384608-5 2006 Exposure of the placentas to MgSO4 resulted in significant increase in TNF-alpha and IL-6 in the maternal site (p < 0.05). Magnesium Sulfate 29-34 interleukin 6 Homo sapiens 85-89 16384608-8 2006 The fetal site of the placentas exposed to MgSO4 or AII separately showed only basal levels of TNF-alpha and IL-6. Magnesium Sulfate 43-48 interleukin 6 Homo sapiens 109-113 16384608-9 2006 However, TNF-alpha and IL-6 levels were significantly higher after injection of AII in the presence of MgSO4 compared to TNF-alpha levels in the fetal site of placentas exposed to AII alone (p < 0.05) or MgSO4 alone (p < 0.01). Magnesium Sulfate 103-108 interleukin 6 Homo sapiens 23-27 16384608-10 2006 MgSO4 induced the ability of the placental maternal site to secrete TNF-alpha and IL-6. Magnesium Sulfate 0-5 interleukin 6 Homo sapiens 82-86 16246469-4 2006 However, both wild type meningococcal LOS and KDO(2)-lipid A, significantly up-regulated CD80, CD83 and CD86 and released significantly higher amounts of IL-12p70, IL-6, IL-10, TNFalpha, MCP-1, IP-10 and RANTES. Kdo2-lipid A 46-60 interleukin 6 Homo sapiens 164-168 16436856-8 2006 Perineural clonidine, but not saline, partially reversed the hypersensitivity, accompanied by reduced concentrations of interleukin 6 and interleukin 1beta in the sciatic nerve. Clonidine 11-20 interleukin 6 Homo sapiens 120-133 16306311-7 2006 Those with the lowest levels of alpha- and beta-carotene, lutein/zeaxanthin, and total carotenoids were significantly more likely to have increasing IL-6 levels over a period of 2 years. Lutein 58-64 interleukin 6 Homo sapiens 149-153 16501663-5 2006 In univariate analysis age, hypertension, diabetes, smoking, moderate alcohol use, total homocysteine, carotid intima media thickness, and body mass index were positively associated with IL-6 levels. Homocysteine 89-101 interleukin 6 Homo sapiens 187-191 16274887-3 2005 When macrophages were incubated in sulfur amino acid-deprived medium, lipopolysaccharide induction of iNOS, TNFalpha, IL-1beta, and IL-6 was significantly decreased compared to control. Amino Acids, Sulfur 35-52 interleukin 6 Homo sapiens 132-136 16155293-1 2005 We previously demonstrated that trans-10, cis-12 conjugated linoleic acid (CLA) reduced the triglyceride content of human adipocytes by activating mitogen-activated protein kinase kinase/extracellular signal-related kinase (MEK/ERK) signaling via interleukins (IL) 6 and 8. trans-10, cis-12 32-48 interleukin 6 Homo sapiens 247-272 16223437-0 2005 Inhibitory effect of PPAR-gamma activator on IL-6 and mPGES protein expression in PBMC induced by homocysteine. Homocysteine 98-110 interleukin 6 Homo sapiens 45-49 16223437-1 2005 The objective was to investigate the relationship between homocysteine (HCY), peroxisome proliferator-activated receptors (PPAR)-gamma and the expression of interleukin 6 (IL-6) and microsomal prostaglandin E synthase (mPGES) by peripheral blood mononuclear cell (PBMC) culture in vitro, as well as to look at the intervention with HCY and PPAR-gamma activators (troglitazone and rosiglitazone). Homocysteine 58-70 interleukin 6 Homo sapiens 157-170 16223437-1 2005 The objective was to investigate the relationship between homocysteine (HCY), peroxisome proliferator-activated receptors (PPAR)-gamma and the expression of interleukin 6 (IL-6) and microsomal prostaglandin E synthase (mPGES) by peripheral blood mononuclear cell (PBMC) culture in vitro, as well as to look at the intervention with HCY and PPAR-gamma activators (troglitazone and rosiglitazone). Homocysteine 58-70 interleukin 6 Homo sapiens 172-176 16223437-1 2005 The objective was to investigate the relationship between homocysteine (HCY), peroxisome proliferator-activated receptors (PPAR)-gamma and the expression of interleukin 6 (IL-6) and microsomal prostaglandin E synthase (mPGES) by peripheral blood mononuclear cell (PBMC) culture in vitro, as well as to look at the intervention with HCY and PPAR-gamma activators (troglitazone and rosiglitazone). Homocysteine 72-75 interleukin 6 Homo sapiens 157-170 15913932-1 2005 In the present study, we investigated the signal transduction pathways of expression of IL-6 in the desferrioxamine (DFX)-stimulated cochlear auditory cell line, HEI-OC1 cells. Deferoxamine 100-115 interleukin 6 Homo sapiens 88-92 15913932-1 2005 In the present study, we investigated the signal transduction pathways of expression of IL-6 in the desferrioxamine (DFX)-stimulated cochlear auditory cell line, HEI-OC1 cells. Deferoxamine 117-120 interleukin 6 Homo sapiens 88-92 15913932-3 2005 DFX significantly increased the production of IL-6 (P<0.05) and expression of IL-6 mRNA but did not affect TNF-alpha production. Deferoxamine 0-3 interleukin 6 Homo sapiens 46-50 15913932-3 2005 DFX significantly increased the production of IL-6 (P<0.05) and expression of IL-6 mRNA but did not affect TNF-alpha production. Deferoxamine 0-3 interleukin 6 Homo sapiens 81-85 15913932-5 2005 Increased IL-6 by DFX was significantly inhibited by p38 inhibitor, SB203580 (about 72% inhibition, P=0.027) but not ERK inhibitor, PD98059 or JNK inhibitor, SP600125. Deferoxamine 18-21 interleukin 6 Homo sapiens 10-14 16145309-5 2005 In a minority of patients, estrogen-progestogen associations and tibolone increased IL-6 levels and induced unfavorable changes on inflammation markers (CRP: +93% +/- 8%, intracellular adhesion molecule: -3% +/- 2%, vascular cell adhesion molecule: -5% +/- 2%, E-selectin: +6% +/- 2%, s-thrombomodulin: +5% +/- 2%, IL-6: +12% +/- 4%; percent changes compared with baseline). tibolone 65-73 interleukin 6 Homo sapiens 84-88 15972472-6 2005 Under conditions of LLO-induced pore formation without extensive cell lysis, Ca2+ influx was observed, and the IL-6 expression induced by rLLO was inhibited by pretreatment with 1,2-bis(2-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid tetrakis(acetoxymethyl ester) (BAPTA-AM), an intracellular Ca2+ chelator. 1,2-bis(2-aminophenoxy)ethane-n,n,n",n"-tetraacetic acid tetrakis(acetoxymethyl ester) 178-264 interleukin 6 Homo sapiens 111-115 15992579-0 2005 Serotonin 5-HT7 receptors coupled to induction of interleukin-6 in human microglial MC-3 cells. mc-3 84-88 interleukin 6 Homo sapiens 50-63 15969670-0 2005 The mycotoxins citrinin and gliotoxin differentially affect production of the pro-inflammatory cytokines tumour necrosis factor-alpha and interleukin-6, and the anti-inflammatory cytokine interleukin-10. Gliotoxin 28-37 interleukin 6 Homo sapiens 138-151 15969670-13 2005 We suggest that low exposure doses of citrinin and gliotoxin (corresponding to less than 100 ng/mL gliotoxin and less than 10 mug/mL citrinin) may inhibit IL-10 and lead to increased risk of an inflammatory response with relative overproduction of TNF-alpha and IL-6. Gliotoxin 51-60 interleukin 6 Homo sapiens 262-266 15924880-5 2005 Sabaeksan (1 mg/ml) inhibited PMA plus A23187-induced TNF-alpha, IL-6, and IL-8 secretion by 43.86+/-5.26%, 56.39+/-3.65%, and 63.48+/-2.54%, respectively. sabaeksan 0-9 interleukin 6 Homo sapiens 65-69 15759024-7 2005 Systolic and diastolic blood pressure decreased significantly (P<0.01) in parallel to serum IL-6 levels (from 3.72+/-0.82 to 3.23+/-0.19 pg/ml, P=0.02) reaching a similar concentration to normotensive patients (3.33+/-0.3 pg/ml) after treatment with irbesartan. Irbesartan 253-263 interleukin 6 Homo sapiens 95-99 15942580-7 2005 End-of-surgery interleukin 6 levels and 24-hour postoperative troponin I levels were significantly ( P < .01) lower in the patients in the AT group than in the RTC group. Astatine 142-144 interleukin 6 Homo sapiens 15-28 15689417-7 2005 Therefore, iAs may enhance the expression of HO-1, MCP-1, and IL-6 in VSMCs via different reactive oxygen molecules. 4-Iodoacetamidosalicylic acid 11-14 interleukin 6 Homo sapiens 62-66 15833109-4 2005 RT-PCR analysis showed PAF treatment of microglia induced expression of the pro-inflammatory cytokine IL-6 in a time-dependent manner which was blocked in the presence of SKF96365. 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole 171-179 interleukin 6 Homo sapiens 102-106 15781640-0 2005 Dehydroepiandrosterone can inhibit the proliferation of myeloma cells and the interleukin-6 production of bone marrow mononuclear cells from patients with myeloma. Dehydroepiandrosterone 0-22 interleukin 6 Homo sapiens 78-91 15901049-5 2005 Significantly decreased concentrations of beta2-MG, IL-6 and total protein were found in both BAP and BP. Benzo(a)pyrene 102-104 interleukin 6 Homo sapiens 52-56 15777258-6 2005 Ketamine prevent the pro-inflammatory cytokine (TNF-alpha, IL-1, and IL-6) responses to endotoxemia in vivo. Ketamine 0-8 interleukin 6 Homo sapiens 69-73 15848526-5 2005 The tubular expression of mRNA for IL-6 and TGF-beta1 was significantly lower in biopsies with AR (n = 34) obtained from patients treated with MMF (n = 12) than in biopsies obtained from patients treated with azathioprine (n = 22) (P < .02). Mycophenolic Acid 143-146 interleukin 6 Homo sapiens 35-39 15848526-5 2005 The tubular expression of mRNA for IL-6 and TGF-beta1 was significantly lower in biopsies with AR (n = 34) obtained from patients treated with MMF (n = 12) than in biopsies obtained from patients treated with azathioprine (n = 22) (P < .02). Azathioprine 209-221 interleukin 6 Homo sapiens 35-39 15760531-4 2005 RESULTS: After operation, the contents of IL-6, IL-8, TNF-alpha, CK-MB and cTnI were significantly higher in CCABG group than those before operation and those in OPCABG group, while most of these parameters showed little change in OPCABG group both in operative or postoperative period. ccabg 109-114 interleukin 6 Homo sapiens 42-46 16179748-1 2005 Homocysteine, cytokines (IL-18, IL-6, IL-8) are involved in vascular inflammation and coronary artery disease. Homocysteine 0-12 interleukin 6 Homo sapiens 32-36 16179748-2 2005 Homocysteine influences endothelial IL-6 and IL-8 cytokine expression and release, however, an association between homocysteine and IL-18 has not been previously investigated in endothelial/smooth muscle cells and or in coronary artery disease. Homocysteine 0-12 interleukin 6 Homo sapiens 36-40 16435585-7 2005 Also, DCWGG inhibited TNF-alpha, IL-1alpha, IL-beta, IL-6, and IL-8 production-induced DFX in dose-dependent manner. Deferoxamine 87-90 interleukin 6 Homo sapiens 53-57 16696312-5 2005 In the unstable angina group, IL-6 levels were obviously positively correlated with TC (r = 0.314, P = 0.023), but not with TG and HDL. Technetium 84-86 interleukin 6 Homo sapiens 30-34 16151578-8 2005 In our hands 4"-DM-6-Mptox was found to induce concentration-dependent NF-kB inhibition in HeLa cells as assessed by the IL-6 luciferase gene reporter assay, which though not quite prominent, at least partly contributes to the cytotoxic potential of the tested lignan. 4"-dm-6-mptox 13-26 interleukin 6 Homo sapiens 121-125 15308634-11 2004 This together with the suppression of UVA irradiation-induced IL-6 release in the presence of Trolox, a chain breaker of PCOOH-initiated lipid peroxidation, indicates that UVA irradiation-induced PCOOHs and subsequent lipid peroxides initiate the NFkappaB-mediated induction of IL-6, which mediates the induction of MMP-1. 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 94-100 interleukin 6 Homo sapiens 278-282 15488155-11 2004 Thus, Gl A+ and AG-EB+ ENC produce IL-1beta, IL-2, IL-4, IL-6, IFN-gamma, TGF-beta1 and TNF-alpha. gamma-Linolenic Acid 6-10 interleukin 6 Homo sapiens 57-61 15488263-5 2004 RESULTS: BAD patients under chronic lithium treatment had significantly lower numbers of IL-2, IL-6, IL-10 and IFN-gamma secreting cells compared to healthy volunteers. Lithium 36-43 interleukin 6 Homo sapiens 95-99 15488263-8 2004 CONCLUSIONS: The significantly lower number of PBLs producing cytokines (IL-2, IL-6, IL-10 and IFN-gamma) in euthymic BAD patients under chronic lithium treatment result from the long-term (over 3 months) lithium administration. Lithium 145-152 interleukin 6 Homo sapiens 79-83 15383598-8 2004 Lipidated (L)-Omp16 and L-Omp19, but not their unlipidated forms, induced the secretion of TNF-alpha, IL-6, IL-10, and IL-12 in a time- and dose-dependent fashion. (l)-omp16 10-19 interleukin 6 Homo sapiens 102-106 15255954-0 2004 Beta-naphthoflavone disturbs astrocytic differentiation of C6 glioma cells by inhibiting autocrine interleukin-6. beta-Naphthoflavone 0-19 interleukin 6 Homo sapiens 99-112 15255954-2 2004 Here we show that beta-naphthoflavone (betaNF), an agonist of the aryl hydrocarbon receptor (AhR), disturbed the cAMP-induced astrocytic differentiation of C6 glioma by inhibiting autocrine interleukin-6 (IL-6). beta-Naphthoflavone 18-37 interleukin 6 Homo sapiens 190-203 15255954-2 2004 Here we show that beta-naphthoflavone (betaNF), an agonist of the aryl hydrocarbon receptor (AhR), disturbed the cAMP-induced astrocytic differentiation of C6 glioma by inhibiting autocrine interleukin-6 (IL-6). beta-Naphthoflavone 18-37 interleukin 6 Homo sapiens 205-209 15727386-3 2004 In this study we aimed to evaluate the influence of PTX on plasma levels of tumor necrosis factor (TNF) alpha and interleukin (IL)-6 in newborn infants with sepsis. Pentoxifylline 52-55 interleukin 6 Homo sapiens 114-132 15240743-4 2004 RAPBTL (n = 20) induced an up-regulation of ICAM-1, intracellular IL-8, IL-6, IL-15, and surface IL-15 in cocultured RASFibs. rapbtl 0-6 interleukin 6 Homo sapiens 72-76 15155343-9 2004 TCV-309 significantly inhibited the production of TNF, IL-6, and IL-8 induced by LPS, SEB, and bacteria. TCV 309 0-7 interleukin 6 Homo sapiens 55-59 15298427-0 2004 Methylprednisolone prevents inflammatory reaction occurring during cardiopulmonary bypass: effects on TNF-alpha, IL-6, IL-8, IL-10. Methylprednisolone 0-18 interleukin 6 Homo sapiens 113-117 14754894-5 2004 On the other hand, the IL-6 gene was quickly induced by Bt(2)AMP/theophylline, and subsequent IL-6 protein secretion was stimulated. bt(2)amp 56-64 interleukin 6 Homo sapiens 23-27 14754894-7 2004 Most importantly, treatment with IL-6-neutralizing antibody dramatically reduced the cAMP-induced GFAP expression and STAT3 phosphorylation and reversed the cellular morphological changes that had been caused by Bt(2)AMP/theophylline. bt(2)amp 212-220 interleukin 6 Homo sapiens 33-37 14754894-8 2004 Taken together, these results indicated that Bt(2)AMP/theophylline lead to delayed STAT3 activation via autocrine IL-6. bt(2)amp 45-53 interleukin 6 Homo sapiens 114-118 15086213-0 2004 Effect of octreotide administration on serum interleukin-6 (IL-6) levels of patients with acute edematous pancreatitis. Octreotide 10-20 interleukin 6 Homo sapiens 45-58 15086213-0 2004 Effect of octreotide administration on serum interleukin-6 (IL-6) levels of patients with acute edematous pancreatitis. Octreotide 10-20 interleukin 6 Homo sapiens 60-64 15086213-1 2004 BACKGROUND/AIMS: Based on former studies in experimental animals on the effect of octreotide on serum and ascitic levels of tumor necrosis factor-alpha and interleukin-6 in the field of necrotizing pancreatitis, the present study was designed to investigate the effect of octreotide on serum interleukin-6 of patients with acute edematous pancreatitis. Octreotide 82-92 interleukin 6 Homo sapiens 156-169 15086213-1 2004 BACKGROUND/AIMS: Based on former studies in experimental animals on the effect of octreotide on serum and ascitic levels of tumor necrosis factor-alpha and interleukin-6 in the field of necrotizing pancreatitis, the present study was designed to investigate the effect of octreotide on serum interleukin-6 of patients with acute edematous pancreatitis. Octreotide 82-92 interleukin 6 Homo sapiens 292-305 15086213-5 2004 RESULTS: Mean concentrations of interleukin-6 of patients treated with octreotide 200 microg tid were 59.52 pg/mL before and 94.08, 46.25, 49.94, 58.16 and 26.08 pg/mL at 3, 6, 24, 48 and 72 hours after the start of therapy respectively. Octreotide 71-81 interleukin 6 Homo sapiens 32-45 15086213-9 2004 CONCLUSIONS: A transient, but not statistically significant, decrease of serum interleukin-6 levels was documented after administration of octreotide in the field of acute edematous pancreatitis. Octreotide 139-149 interleukin 6 Homo sapiens 79-92 14687223-1 2004 OBJECTIVE: To investigate whether sub-antimicrobial dose doxycycline (SDD) therapy for 120 d in chronic adult periodontitis patients had significant effects on gingival crevicular fluid (GCF) matrix metalloproteinase-8 (MMP-8) levels, and on gingival tissue MMP-9, tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) and interleukin-6 (IL-6) levels. Doxycycline 57-68 interleukin 6 Homo sapiens 326-339 14687223-1 2004 OBJECTIVE: To investigate whether sub-antimicrobial dose doxycycline (SDD) therapy for 120 d in chronic adult periodontitis patients had significant effects on gingival crevicular fluid (GCF) matrix metalloproteinase-8 (MMP-8) levels, and on gingival tissue MMP-9, tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) and interleukin-6 (IL-6) levels. Doxycycline 57-68 interleukin 6 Homo sapiens 341-345 14692430-10 2003 Budesonide aqueous nasal spray treatment showed a significant decrease of IL-4 (P = .007), IL-5 (P = .04), and IL-6 levels (P = .009). Budesonide 0-10 interleukin 6 Homo sapiens 111-115 12973171-13 2003 A positive relationship was demonstrated between plasma levels of tumor necrosis factor-alpha and interleukin-6 and the PCO2 gap throughout the study. pco2 120-124 interleukin 6 Homo sapiens 98-111 12884825-13 2003 We recognized four clinical features in both cases as follows: 1. the episode of preceding infection such as common cold, 2. appearance of reversible high signal intensity lesions in bilateral hippocampi and amygdaloid bodies on DWI, 3. elevation of only IL-6 in CSF, and 4. marked neurological improvement by intravenous administration of high-dose methylprednisolone. Methylprednisolone 350-368 interleukin 6 Homo sapiens 255-259 12944727-10 2003 CONCLUSION: The amino acid imbalance in patients with septic encephalopathy may be a marker for the severity of the septic syndrome, and PMX-F hemoperfusion is effective in ameliorating the increased plasma endotoxin and IL-6 levels and the amino acid imbalance in these patients. pmx-f 137-142 interleukin 6 Homo sapiens 221-225 12468058-8 2003 Changes in IL-6 (DeltaIL-6) correlated with Deltaepinephrine (r=0.63, P<0.0001) and Deltanorepinephrine (r=0.57, P=0.0006) in controls, but not in CHF. deltaepinephrine 44-60 interleukin 6 Homo sapiens 11-15 12324813-0 2002 Does megestrol acetate down-regulate interleukin-6 in patients? Megestrol Acetate 5-22 interleukin 6 Homo sapiens 37-50 12215492-6 2002 On the other hand, PPAR-gamma ligands troglitazone, pioglitazone, and 15-deoxy-Delta(12,14)-prostaglandin J(2) inhibited IL-1beta-induced IL-6 expression at a transcriptional revel in VSMCs. prostaglandin j 92-107 interleukin 6 Homo sapiens 138-142 12143044-5 2002 HGF and IL-6 also induced a rapid release of arachidonic acid (AA) from SG231 and increased the synthesis of PGE(2) and PGF(2)alpha. Prostaglandins F 120-123 interleukin 6 Homo sapiens 8-12 12135668-9 2002 beta-lapachone also decreased binding of MM.1S cells to BMSCs; abrogated IL-6 and VEGF secretion triggered by adhesion of BMSCs to MM.1S cells; reduced proliferation of MM.1S cells adherent to BMSCs; and decreased intracellular adhesion molecule-1 (ICAM-1) expression on MM.1S cells. beta-lapachone 0-14 interleukin 6 Homo sapiens 73-77 11981085-7 2002 There was an association between symptoms and increased levels of mycophenolic acid (MPA) acyl glucuronide and serum interleukin-6, suggesting the induction of inflammatory cytokines by MPA acyl glucuronide as the cause of the syndrome. Mycophenolic Acid 66-83 interleukin 6 Homo sapiens 117-130 11957164-7 2002 MEASUREMENTS AND MAIN RESULTS: Patients who received methylprednisolone had a significant reduction in circulating interleukin (IL)-6 at 60 minutes after CPB (p < 0.05) and on the morning of the 1st (p < 0.01) and 3rd (p < 0.05) postoperative days and a significant increase in circulating IL-10 at 60 minutes after CPB (p < 0.01) compared with the placebo group. Methylprednisolone 53-71 interleukin 6 Homo sapiens 115-133 11950021-10 2002 ACECLO, DICLO, INDO, NIM significantly inhibited basal and IL-1beta stimulated IL-6 production; CELE and IBUP only inhibited IL-1beta stimulated IL-6 production; and ROFE and PIROX had no significant effects. Celecoxib 96-100 interleukin 6 Homo sapiens 145-149 11886764-8 2002 There was an inverse relationship between serum DHEA and DHEA-S levels and both IL-6 (r= -0.46, P<0.02) or IL-18 (r= -0.38, P<0.05) serum concentrations. Dehydroepiandrosterone 48-52 interleukin 6 Homo sapiens 80-84 11886764-8 2002 There was an inverse relationship between serum DHEA and DHEA-S levels and both IL-6 (r= -0.46, P<0.02) or IL-18 (r= -0.38, P<0.05) serum concentrations. Dehydroepiandrosterone 57-63 interleukin 6 Homo sapiens 80-84 12090904-7 2002 Inhibition of Rho by C3 exoenzyme or Rho kinase by Y-27632 significantly decreased IL-6 expression in VSMCs. Y 27632 51-58 interleukin 6 Homo sapiens 83-87 11716958-0 2002 Inhibition of type 2,5"-deiodinase by tumor necrosis factor alpha, interleukin-6 and interferon gamma in human thyroid tissue. type 2,5"-deiodinase 14-34 interleukin 6 Homo sapiens 67-80 12230916-7 2002 In human PAECs, IL-6 and TXA(2) release induced by LPS (0-1 microg/ml) or CCPA (0-1 microM) at high doses was significantly reduced by the selective A(1) adenosine receptor antagonist, 8-cyclopentyl-1,3-dipropylxanthine (DPCPX; 1 microM). N(6)-cyclopentyladenosine 74-78 interleukin 6 Homo sapiens 16-20 12537693-10 2002 In corroboration of previous findings with studies employing compound 516, purified LA(hepta) was found to induce the production of TNF-alpha, IL-1beta and IL-6 in hMNC, thus displaying moderate agonistic activity. Heptachlor 87-92 interleukin 6 Homo sapiens 156-160 14600946-15 2002 CONCLUSION: We conclude that ICAM-1 and IL-6 may be important factors in the estimation of the inflammatory processes in the thyroid gland during radioiodine therapy, especially GD disease. Iodine-131 146-157 interleukin 6 Homo sapiens 40-44 11777191-0 2002 Does megestrol acetate down-regulate interleukin-6 in patients with cancer-associated anorexia and weight loss? Megestrol Acetate 5-22 interleukin 6 Homo sapiens 37-50 11751424-11 2001 This study also determined the level of 8-hydroxydeoxyguanosine (8-OH-dGua), an indicator for oxidative DNA lesions in IL-6-treated or mcl-1-overexpressed AGS cells after treatment with H(2)O(2). 8-ohdg 40-63 interleukin 6 Homo sapiens 119-123 11747626-6 2001 In human osteoblasts (SaM-1 cells) treated with 10 microg/ml LPS, increases in IL-6 mRNA and synthesis were inhibited by anti-CD14 antibody (MEM-18), PD98059 (an inhibitor of classic mitogen-activated protein kinase [MAPK]), or SB203580 (an inhibitor of p38 MAPK) but were not inhibited by H-89 (an inhibitor of protein kinase A [PKA]) and calphostin C (an inhibitor of protein kinase C [PKC]). N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide 290-294 interleukin 6 Homo sapiens 79-83 11747626-6 2001 In human osteoblasts (SaM-1 cells) treated with 10 microg/ml LPS, increases in IL-6 mRNA and synthesis were inhibited by anti-CD14 antibody (MEM-18), PD98059 (an inhibitor of classic mitogen-activated protein kinase [MAPK]), or SB203580 (an inhibitor of p38 MAPK) but were not inhibited by H-89 (an inhibitor of protein kinase A [PKA]) and calphostin C (an inhibitor of protein kinase C [PKC]). calphostin C 340-352 interleukin 6 Homo sapiens 79-83 11688002-14 2001 At 6 hours after CPB, the increase in IL-6 levels in methylprednisolone-treated patients was significantly less compared with levels measured in control patients and aprotinin-treated patients (p < 0.001). Methylprednisolone 53-71 interleukin 6 Homo sapiens 38-42 11688002-17 2001 CONCLUSION: This study showed that methylprednisolone suppresses TNF-alpha, IL-6, and IL-8 release; however, aprotinin attenuates IL-8 release alone. Methylprednisolone 35-53 interleukin 6 Homo sapiens 76-80 11853289-10 2001 It has been known that DHEA can lower the levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha). Dehydroepiandrosterone 23-27 interleukin 6 Homo sapiens 52-65 11853289-10 2001 It has been known that DHEA can lower the levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha). Dehydroepiandrosterone 23-27 interleukin 6 Homo sapiens 67-71 12536733-0 2001 [Effects of katamine on cardiopulmonary bypass-induced interleukin-6 and interleukin-8 response and its significance]. katamine 12-20 interleukin 6 Homo sapiens 55-68 12536733-1 2001 OBJECTIVE: To investigate the effects of ketamine on cardiopulmonary bypass-induced IL-6 and IL-8 response. Ketamine 41-49 interleukin 6 Homo sapiens 84-88 12536733-6 2001 CONCLUSIONS: Ketamine is effective to reduce cardiopulmonary bypass-induces IL-6 and IL-8 response and protect reperfusion myocardium. Ketamine 13-21 interleukin 6 Homo sapiens 76-80 11592504-0 2001 New bioactive cyclopentenone derivatives as inhibitors of the IL-6 dependent signal transduction. cyclopentenone 14-28 interleukin 6 Homo sapiens 62-66 11301047-5 2001 During 72 hr of incubation with or without LPS, the ability of PTX to influence the secretion of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), acute phase proteins, and nitric oxide (NO) was assessed. Pentoxifylline 63-66 interleukin 6 Homo sapiens 139-152 11301047-5 2001 During 72 hr of incubation with or without LPS, the ability of PTX to influence the secretion of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), acute phase proteins, and nitric oxide (NO) was assessed. Pentoxifylline 63-66 interleukin 6 Homo sapiens 154-158 11301047-6 2001 PTX completely inhibited LPS-induced TNF-alpha production and attenuated IL-6 only after 48 hr of incubation. Pentoxifylline 0-3 interleukin 6 Homo sapiens 73-77 11301047-10 2001 The present results show that PTX differentially affects the endotoxin-induced inflammatory response in primary porcine liver cell cultures by suppressing TNF-alpha and IL-6 while potentiating NO production. Pentoxifylline 30-33 interleukin 6 Homo sapiens 169-173 11446747-3 2001 Here, we demonstrate that hypoestoxide (HE) abrogates the production of pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) in lipopolysaccharide (LPS)-activated normal human peripheral blood mononuclear cells. hypoestoxide 26-38 interleukin 6 Homo sapiens 110-114 11446747-3 2001 Here, we demonstrate that hypoestoxide (HE) abrogates the production of pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) in lipopolysaccharide (LPS)-activated normal human peripheral blood mononuclear cells. hypoestoxide 40-42 interleukin 6 Homo sapiens 110-114 11410418-6 2001 RESULTS: Throughout storage, refrigerated PCs, both ThromboSol-treated and untreated units, displayed a slightly lower level of IL-6 and significantly lower concentration of IL-8 than conventionally stored PCs. thrombosol 52-62 interleukin 6 Homo sapiens 128-132 11392584-0 2001 Effect of budesonide and nedocromil sodium on IL-6 and IL-8 release from human nasal mucosa and polyp epithelial cells. Nedocromil 25-42 interleukin 6 Homo sapiens 46-50 11392584-1 2001 We investigated the effect of budesonide and nedocromil sodium on the secretion of IL-6 and IL-8 by cultured epithelial cells from healthy nasal mucosa and nasal polyps. Budesonide 30-40 interleukin 6 Homo sapiens 83-87 11392584-1 2001 We investigated the effect of budesonide and nedocromil sodium on the secretion of IL-6 and IL-8 by cultured epithelial cells from healthy nasal mucosa and nasal polyps. Nedocromil 45-62 interleukin 6 Homo sapiens 83-87 11392584-3 2001 Budesonide inhibited FCS-induced IL-6 and IL-8 release in a dose-dependent manner. Budesonide 0-10 interleukin 6 Homo sapiens 33-37 11392584-4 2001 The IC25 (25% inhibitory concentration) of budesonide on IL-6 release was higher in nasal polyp than in nasal mucosa epithelial cells (34 nM vs. 200 pM). Budesonide 43-53 interleukin 6 Homo sapiens 57-61 11392584-6 2001 Nedocromil sodium caused a dose-related inhibitory effect on IL-8 release from nasal mucosa (IC25, 207 nM), while it only had a significant effect in nasal polyps at 10(-5) M. Nedocromil sodium had no effect on IL-6 release. Nedocromil 0-17 interleukin 6 Homo sapiens 211-215 11392584-8 2001 Budesonide and nedocromil sodium may exert their anti-inflammatory action in the respiratory mucosa by modulating the secretion of IL-6 and IL-8. Budesonide 0-10 interleukin 6 Homo sapiens 131-135 11392584-8 2001 Budesonide and nedocromil sodium may exert their anti-inflammatory action in the respiratory mucosa by modulating the secretion of IL-6 and IL-8. Nedocromil 15-32 interleukin 6 Homo sapiens 131-135 11392584-9 2001 The different effect of budesonide and nedocromil sodium on IL-6 and IL-8 release may be explained by differences in the mechanisms which regulate the upregulation of these cytokines in inflammatory responses. Budesonide 24-34 interleukin 6 Homo sapiens 60-64 11392584-9 2001 The different effect of budesonide and nedocromil sodium on IL-6 and IL-8 release may be explained by differences in the mechanisms which regulate the upregulation of these cytokines in inflammatory responses. Nedocromil 39-56 interleukin 6 Homo sapiens 60-64 11238657-6 2001 Histamine-induced beta-glucuronidase and IL-6 release and [Ca(2+)](i) elevation were inhibited by the selective H(1) antagonist fexofenadine (10(-7)-10(-4) M), but not by the H(2) antagonist ranitidine. fexofenadine 128-140 interleukin 6 Homo sapiens 41-45 11238657-7 2001 Inhibition of histamine-induced beta-glucuronidase and IL-6 release by fexofenadine was concentration dependent and displayed the characteristics of a competitive antagonism (K(d) = 89 nM). fexofenadine 71-83 interleukin 6 Homo sapiens 55-59 11133502-3 2001 PGE(2) (10(-7) to 10(-10) M) induced a dose-related increase in IL-6 release at 24 h. PGF(2 alpha) (10(-6) M) treatment caused a similar effect to that of PGE(2) (10(-7) M). Prostaglandins F 86-89 interleukin 6 Homo sapiens 64-68 11403239-8 2001 A positive correlation was found between the concentration of IL-6 and the contents of benzoylperoxide (p = 0.0003) and barium sulphate (p < 0.0001). Barium Sulfate 120-135 interleukin 6 Homo sapiens 62-66 11137522-4 2001 Our results show that lipopolysaccarides (LPS) stimulated PBMC from both symptomatic and asymptomatic patients have an increased production of IL-12 and TNFalpha compared to controls, while after phitoemoagglutinin (PHA) stimulation we observed a decreased production of IL-6 and IL-10. lipopolysaccarides 22-40 interleukin 6 Homo sapiens 271-275 11007619-13 2000 The pharmacologic agents (ciprofloxacin, pentoxifylline, and indomethacin) that can modulate the release of bone resorbing mediators such as PGE(2), TNF-alpha, IL-1, and IL-6 release from human monocytes. Pentoxifylline 41-55 interleukin 6 Homo sapiens 170-174 11149437-10 2000 The elevated Tc was associated with an increased IL-6 response but not with leukocytosis. Technetium 13-15 interleukin 6 Homo sapiens 49-53 11037876-1 2000 OBJECTIVE: Taurine chloramine (Tau-Cl) has been shown to inhibit the production of proinflammatory cytokines (interleukin-6 [IL-6] and IL-8) by fibroblast-like synoviocytes (FLS) isolated from rheumatoid arthritis (RA) patients. chloramine 19-29 interleukin 6 Homo sapiens 110-123 11037876-1 2000 OBJECTIVE: Taurine chloramine (Tau-Cl) has been shown to inhibit the production of proinflammatory cytokines (interleukin-6 [IL-6] and IL-8) by fibroblast-like synoviocytes (FLS) isolated from rheumatoid arthritis (RA) patients. chloramine 19-29 interleukin 6 Homo sapiens 125-129 10884313-4 2000 Pretreatment of astrocytes with P2 receptor antagonists, including suramin and periodate oxidized ATP (oATP), resulted in a significant downregulation of IL-1beta-stimulated expression of nitric oxide, tumor necrosis factor (TNFalpha), and IL-6 at both the protein and mRNA levels, without affecting cell viability. 2',3'-dialdehyde ATP 103-107 interleukin 6 Homo sapiens 240-244 10840457-14 2000 CONCLUSIONS: Losartan is associated with downregulation of TGF-beta, IFN-gamma and IL-6 and may, in combination with antimicrobial therapy, reduce the risk of cortical renal scarring in recurrent acute pyelonephritis in infants. Losartan 13-21 interleukin 6 Homo sapiens 83-87 10825337-6 2000 In the comparison study between the control group and the clonidine group, there was a significant decrease in IL-6 level 3 h after the start of surgery and IL-1beta at preinduction time in the clonidine group, whereas there were no changes in tumor necrosis factor-alpha, cortisol, and ACTH levels. Clonidine 58-67 interleukin 6 Homo sapiens 111-115 11294501-4 2000 NeuAc-IL-1alpha exhibited a marked reduction in the activity to up-regulate serum IL-6, moderate reduction in the activities to up-regulate serum amyloid A and NOx. N-Acetylneuraminic Acid 0-5 interleukin 6 Homo sapiens 82-86 11147963-11 2000 Binding of the heat shock factor (HSF) to the heat shock element (HSE) in the presence of herbimycin A or delta12PGJ2, and the effects of DTT, mirrored the results of Hsp70 induction. herbimycin 90-102 interleukin 6 Homo sapiens 15-32 11147963-11 2000 Binding of the heat shock factor (HSF) to the heat shock element (HSE) in the presence of herbimycin A or delta12PGJ2, and the effects of DTT, mirrored the results of Hsp70 induction. herbimycin 90-102 interleukin 6 Homo sapiens 34-37 10863963-4 2000 Ligation of adenosine receptors with adenosine or its related analogue, 2-chloroadenosine (2-CADO), increased IL-6 production by HGF without any other stimuli. 2-Chloroadenosine 72-89 interleukin 6 Homo sapiens 110-114 10863963-4 2000 Ligation of adenosine receptors with adenosine or its related analogue, 2-chloroadenosine (2-CADO), increased IL-6 production by HGF without any other stimuli. 2-Chloroadenosine 91-97 interleukin 6 Homo sapiens 110-114 10759009-0 2000 Elevated levels of homocysteine increase IL-6 production in monocytic Mono Mac 6 cells. Homocysteine 19-31 interleukin 6 Homo sapiens 41-45 10759009-3 2000 Interleukin (IL)-6 production by monocytic cell line Mono Mac 6 (MM6) was 1.7-fold increased in the presence of 50 micromol/l HCY and 3.5-fold with 200 micromol/l HCY. Homocysteine 126-129 interleukin 6 Homo sapiens 0-18 10759009-3 2000 Interleukin (IL)-6 production by monocytic cell line Mono Mac 6 (MM6) was 1.7-fold increased in the presence of 50 micromol/l HCY and 3.5-fold with 200 micromol/l HCY. Homocysteine 163-166 interleukin 6 Homo sapiens 0-18 10759009-7 2000 In conclusion, increased concentrations of homocysteine induce IL-6 accumulation in monocytic cells. Homocysteine 43-55 interleukin 6 Homo sapiens 63-67 10759009-9 2000 This study is in favor of an association between homocysteine and monocytic IL-6 production. Homocysteine 49-61 interleukin 6 Homo sapiens 76-80 10687873-6 2000 However, 4 microM of fangchinoline and 6 microM of tetrandrine showed 63 and 86% of inhibitions on hIL-6 activity, respectively. fangchinoline 21-34 interleukin 6 Homo sapiens 99-104 10723244-8 2000 Recently, it has been reported that exogeneous IL-6 is an inducer of ADH secretion, and that primary ATL cells and HTLV-I infected cell lines can produce IL-6. adh 69-72 interleukin 6 Homo sapiens 47-51 11268391-6 2000 IL-6 increases dehydroepiandrosterone (DHEA) release from human cells, but decreases DHEA secretion from bovine cells. Dehydroepiandrosterone 15-37 interleukin 6 Homo sapiens 0-4 11268391-6 2000 IL-6 increases dehydroepiandrosterone (DHEA) release from human cells, but decreases DHEA secretion from bovine cells. Dehydroepiandrosterone 39-43 interleukin 6 Homo sapiens 0-4 11268391-6 2000 IL-6 increases dehydroepiandrosterone (DHEA) release from human cells, but decreases DHEA secretion from bovine cells. Dehydroepiandrosterone 85-89 interleukin 6 Homo sapiens 0-4 10954057-4 2000 LPS also stimulated secretion of IL-6 and IL-8 in cultured trophoblasts, which was suppressed by nafamostat mesilate. nafamostat 97-116 interleukin 6 Homo sapiens 33-37 10631636-3 1999 Statistical correlations significantly showed that: (a) AZA lowers TNF-alpha (P = 0.002) and increases IL-4 production (P = 0.0024), and IFN-beta 1 a increases TNF-alpha and decreases IL-4 levels; (b) CST has a negative effect on TNF-alpha, IL-6, and IL-4 synthesis; and (c) AZA, IFN-beta 1 a, and CST diminish IgG OB synthesis (P = 0.001). Azathioprine 56-59 interleukin 6 Homo sapiens 241-245 10469050-2 1999 Recently it has been suggested that the production of IL-6 is influenced by the adrenal hormone dehydroepiandrosterone (DHEA) and its sulphated derivative DHEA-S. Dehydroepiandrosterone 96-118 interleukin 6 Homo sapiens 54-58 10469050-2 1999 Recently it has been suggested that the production of IL-6 is influenced by the adrenal hormone dehydroepiandrosterone (DHEA) and its sulphated derivative DHEA-S. Dehydroepiandrosterone 120-124 interleukin 6 Homo sapiens 54-58 10431997-10 1999 The peak serum levels of interleukin-6 (IL-6) were significantly lower in the magnesium group than those in the placebo group (38.9 +/- 25.0 vs 92.3 +/- 76.5 pg/mL, p = 0.016). Magnesium 78-87 interleukin 6 Homo sapiens 25-38 10431997-10 1999 The peak serum levels of interleukin-6 (IL-6) were significantly lower in the magnesium group than those in the placebo group (38.9 +/- 25.0 vs 92.3 +/- 76.5 pg/mL, p = 0.016). Magnesium 78-87 interleukin 6 Homo sapiens 40-44 10456399-10 1999 The TCA group had significantly higher levels of IL-6 (P = 0.001), IL-8 (P = 0.005) and S100B (P = 0.002) at 24 h. C5b-9 levels were significantly lower in the TCA group: end of CPB (P = 0.001), 30 min (P < 0.001), 2 h (P = 0.002). Trichloroacetic Acid 4-7 interleukin 6 Homo sapiens 49-53 10456399-13 1999 CONCLUSIONS: (1) The TCA group have prolonged rises of IL-6, IL-8 and S100B. Trichloroacetic Acid 21-24 interleukin 6 Homo sapiens 55-59 10429944-3 1999 Having shown recently that in vitro IL-6 depends on the presence of soluble IL-6 receptor alpha (sIL-6Ralpha) to fully exert its effects on chondrocytes, we conducted the present study to analyse the effects of IL-6 on PG synthesis by human articular chondrocytes in the presence of sIL-6Ralpha. sil-6ralpha 97-108 interleukin 6 Homo sapiens 36-40 10429944-3 1999 Having shown recently that in vitro IL-6 depends on the presence of soluble IL-6 receptor alpha (sIL-6Ralpha) to fully exert its effects on chondrocytes, we conducted the present study to analyse the effects of IL-6 on PG synthesis by human articular chondrocytes in the presence of sIL-6Ralpha. sil-6ralpha 97-108 interleukin 6 Homo sapiens 76-80 10429944-3 1999 Having shown recently that in vitro IL-6 depends on the presence of soluble IL-6 receptor alpha (sIL-6Ralpha) to fully exert its effects on chondrocytes, we conducted the present study to analyse the effects of IL-6 on PG synthesis by human articular chondrocytes in the presence of sIL-6Ralpha. sil-6ralpha 97-108 interleukin 6 Homo sapiens 76-80 10429944-3 1999 Having shown recently that in vitro IL-6 depends on the presence of soluble IL-6 receptor alpha (sIL-6Ralpha) to fully exert its effects on chondrocytes, we conducted the present study to analyse the effects of IL-6 on PG synthesis by human articular chondrocytes in the presence of sIL-6Ralpha. sil-6ralpha 283-294 interleukin 6 Homo sapiens 36-40 10429944-14 1999 In conclusion, sIL-6Ralpha potentiates the inhibitory effect of IL-6 on PG synthesis by articular chondrocytes, but the overall effect of IL-6 + IL-6sR is moderate compared to the effects of IL-1. sil-6ralpha 15-26 interleukin 6 Homo sapiens 64-68 10391095-8 1999 Furthermore, neutralizing antibodies to IL-6 or IL-6 receptor abrogated the antiproliferative effects of IL-1beta- and TNF-alpha-pretreated WI-38 conditioned medium. wi-38 140-145 interleukin 6 Homo sapiens 40-44 10391095-8 1999 Furthermore, neutralizing antibodies to IL-6 or IL-6 receptor abrogated the antiproliferative effects of IL-1beta- and TNF-alpha-pretreated WI-38 conditioned medium. wi-38 140-145 interleukin 6 Homo sapiens 48-52 10220287-1 1999 We previously reported that SK2 hybridoma cells that secreted anti-human interleukin-6 (hIL-6) monoclonal antibodies (SK2 mAb) were microencapsulated within alginate-poly(L)lysine-alginate (APA) membranes (APA-SK2 cells) for immunoisolation, and a single intraperitoneal injection of these APA-SK2 cells remarkably improved IgG1 plasmacytosis in hIL-6 transgenic mice (hIL-6 Tgm). alginate-polylysine-alginate 166-188 interleukin 6 Homo sapiens 88-93 10199534-13 1999 CONCLUSIONS: Methylprednisolone reduces the production of IL-6 and IL-8 but not that of IL-10 and IL-1ra. Methylprednisolone 13-31 interleukin 6 Homo sapiens 58-62 10188767-6 1999 On the day of admission, circulating endothelin and NN levels were elevated and related to elevated levels of tumor necrosis factor-alpha and interleukin-6. punky blue 52-54 interleukin 6 Homo sapiens 142-155 9892033-9 1998 Concerning the release of fibroblast products, we observed a dose-dependent decrease of spontaneous IL6 release only in the presence of fexofenadine. fexofenadine 136-148 interleukin 6 Homo sapiens 100-103 10037006-11 1998 IL-6 favoured and maintained adhesion of MM cells to stromal cells spontaneously since its reintroduction in the favoured co-culture system restored their decreased adhesion observed on a glutaraldehyde fixed stromal layer. Glutaral 188-202 interleukin 6 Homo sapiens 0-4 9923057-8 1998 After MC challenge in patients with HDMAR, the concentration of IL-6, but not IL-8, and GM-CSF, was significantly greater on the challenged side than on the contralateral side. Methacholine Chloride 6-8 interleukin 6 Homo sapiens 64-68 9758732-7 1998 Methylprednisolone treatment effectively inhibited the increases in TNF-alpha and IL-6 and the decreases in AT-III and albumin, but did not inhibit the increases in PMN-elastase and TAT levels. Methylprednisolone 0-18 interleukin 6 Homo sapiens 82-86 9758732-9 1998 CONCLUSIONS: These results suggest that methylprednisolone pretreatment attenuates the decrease in AT-III by reducing IL-6 production postoperatively. Methylprednisolone 40-58 interleukin 6 Homo sapiens 118-122 9767281-5 1998 Only dimethylfumarate (DMF) diminished IL-6 and TGF-alpha secretion in the psoriatic cocultures. Dimethyl Fumarate 5-21 interleukin 6 Homo sapiens 39-43 9767281-5 1998 Only dimethylfumarate (DMF) diminished IL-6 and TGF-alpha secretion in the psoriatic cocultures. Dimethyl Fumarate 23-26 interleukin 6 Homo sapiens 39-43 9629565-4 1998 Independent of clozapine dosage and rectal temperature, clozapine treatment in vivo suppressed proliferation and shedding of sIL-2r by PBMC, and the addition of clozapine in vitro induced, relative to unstimulated conditions, PBMC proliferation and secretion of IL-6 and sIL-2r. Clozapine 56-65 interleukin 6 Homo sapiens 262-266 9629565-4 1998 Independent of clozapine dosage and rectal temperature, clozapine treatment in vivo suppressed proliferation and shedding of sIL-2r by PBMC, and the addition of clozapine in vitro induced, relative to unstimulated conditions, PBMC proliferation and secretion of IL-6 and sIL-2r. Clozapine 56-65 interleukin 6 Homo sapiens 262-266 9626133-0 1998 Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence. Dehydroepiandrosterone 30-34 interleukin 6 Homo sapiens 90-103 9626133-0 1998 Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence. Dehydroepiandrosterone 30-34 interleukin 6 Homo sapiens 105-109 9626133-0 1998 Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence. Dehydroepiandrosterone 40-44 interleukin 6 Homo sapiens 90-103 9626133-0 1998 Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence. Dehydroepiandrosterone 40-44 interleukin 6 Homo sapiens 105-109 9626133-6 1998 In female and male subjects, DHEA and ASD concentration dependently inhibited IL-6 production from peripheral blood mononuclear cells (P = 0.001). Dehydroepiandrosterone 29-33 interleukin 6 Homo sapiens 78-82 9626133-8 1998 In summary, the data indicate a functional link between DHEA or ASD and IL-6. Dehydroepiandrosterone 56-60 interleukin 6 Homo sapiens 72-76 9626133-9 1998 It is concluded that the increase in IL-6 production during the process of aging might be due to diminished DHEA and ASD secretion. Dehydroepiandrosterone 108-112 interleukin 6 Homo sapiens 37-41 9660250-0 1998 Serotonin derivative, N-(p-coumaroyl) serotonin, inhibits the production of TNF-alpha, IL-1alpha, IL-1beta, and IL-6 by endotoxin-stimulated human blood monocytes. N-(p-coumaroyl)serotonin 22-47 interleukin 6 Homo sapiens 112-116 9660250-3 1998 CS at 50-200 microM reduced tumor necrosis factor (TNF), interleukin-1 (IL-1), and IL-6 activities in the culture supernatants from LPS-stimulated human blood monocytes without cytotoxicity. N-(p-coumaroyl)serotonin 0-2 interleukin 6 Homo sapiens 83-87 9660250-4 1998 ELISA assay revealed that the production of TNF-alpha, IL-1alpha, IL-1beta, and IL-6 was inhibited by CS. N-(p-coumaroyl)serotonin 102-104 interleukin 6 Homo sapiens 80-84 9684114-5 1998 Measures of bile IL-6 in the "poor" group remained high from 3 to 14 days after PTCD in comparison with the "good" group. ptcd 80-84 interleukin 6 Homo sapiens 17-21 9684114-6 1998 CONCLUSIONS: These results suggest that circulating IL-6, as well as IL-6 in the bile, may be involved in the pathogenesis of obstructive jaundice, and play an important role in preventing the resolution of obstructive jaundice after PTCD. ptcd 234-238 interleukin 6 Homo sapiens 52-56 9628260-5 1998 RESULTS: Anthralin, at concentrations between 5 microM and 25 microM, caused a marked increase in granulocyte macrophage-colony stimulating factor (GM-CSF), interleukin (IL)-6, IL-8 and TNFalpha synthesis that was selectively inhibited by specific antioxidants. Anthralin 9-18 interleukin 6 Homo sapiens 157-175 9525624-7 1998 Furthermore, using pentoxifylline, an inhibitor of NF-kappaB activation, we demonstrate that the NF-kappaB-mediated IL-6 activation by NS1 is uncoupled from the apoptotic pathway. Pentoxifylline 19-33 interleukin 6 Homo sapiens 116-120 9551699-7 1998 CONCLUSION: These findings that leukocyte and platelet counts never increased, despite the increment of the IL-1beta and IL-6 production after the administration of Y-25510, may be explained in part by the negative feedback mechanism induced by IL-10. Y 25510 165-172 interleukin 6 Homo sapiens 121-125 9359399-6 1997 In this study we have examined the HSF DNA-binding activity in HeLa cells maintained in the sorbitol/water binary solution over a wide concentration range (0.1-0.9 M) and in Dulbecco"s medium supplemented with sorbitol or NaCl. Sorbitol 92-100 interleukin 6 Homo sapiens 35-38 9359399-6 1997 In this study we have examined the HSF DNA-binding activity in HeLa cells maintained in the sorbitol/water binary solution over a wide concentration range (0.1-0.9 M) and in Dulbecco"s medium supplemented with sorbitol or NaCl. Sorbitol 210-218 interleukin 6 Homo sapiens 35-38 9391290-9 1997 IL-6 was associated with raised fibrinogen, sialic acid, and triglycerides. N-Acetylneuraminic Acid 44-55 interleukin 6 Homo sapiens 0-4 10072866-7 1997 RESULTS: Four transfectants, PGTAS1, PGTAS6, PGTAS8, PGTAS9, could express IL-6 antisense mRNA and secret decreased bioactive IL-6. pgtas6 37-43 interleukin 6 Homo sapiens 75-79 10072866-7 1997 RESULTS: Four transfectants, PGTAS1, PGTAS6, PGTAS8, PGTAS9, could express IL-6 antisense mRNA and secret decreased bioactive IL-6. pgtas6 37-43 interleukin 6 Homo sapiens 126-130 9507569-8 1997 Tacrolimus inhibited the production of both cytokines by 55%, while 15-deoxyspergualin reduced IL-6 levels by 24% and IL-8 levels by 48% after separate 24 hour treatments. gusperimus 68-86 interleukin 6 Homo sapiens 95-99 9184643-5 1997 A specific protein kinase A inhibitor, H-89, inhibited both CT- and CGRP-induced IL-6 production. N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide 39-43 interleukin 6 Homo sapiens 81-85 9184648-4 1997 Linomide strongly suppressed IFN-gamma and lipopolysaccharide (LPS)-induced IL-1 beta, TNF-alpha and IL-6 mRNA expression in macrophages in vitro as demonstrated by in situ hybridisation. roquinimex 0-8 interleukin 6 Homo sapiens 101-105 9343991-6 1997 The serum levels of IL-1ra and IL-6 before PTCD were significantly higher when the acute cholangitis was more severe. ptcd 43-47 interleukin 6 Homo sapiens 31-35 9343991-8 1997 In group A, the serum level of IL-6 at 5 h after PTCD was significantly correlated to the endotoxin level in bile at this time. ptcd 49-53 interleukin 6 Homo sapiens 31-35 9160101-1 1997 Pentoxifylline and the two analogues HWA138 and HWA448, at concentrations exceeding 60 micrograms/ml, inhibited malaria antigen or lipopolysaccharide (LPS) induced TNF-alpha and IL-1 alpha secretion, but not IL-6 secretion, from human peripheral blood mononuclear cells in vitro. Pentoxifylline 0-14 interleukin 6 Homo sapiens 208-212 9081202-2 1997 They mediate homing of MM cells to the bone marrow and MM cell to bone marrow stromal cell adhesion, with resultant interleukin-6 related autocrine and paracine growth and antiapoptotic affects. paracine 152-160 interleukin 6 Homo sapiens 116-129 9058216-1 1997 OBJECTIVE: To compare the effects of low- and full-dose aprotinin to methylprednisolone (MPS) in reducing cardiopulmonary bypass (CPB)-induced interleukin-6 (IL-6) release. Methylprednisolone 69-87 interleukin 6 Homo sapiens 143-156 9058216-1 1997 OBJECTIVE: To compare the effects of low- and full-dose aprotinin to methylprednisolone (MPS) in reducing cardiopulmonary bypass (CPB)-induced interleukin-6 (IL-6) release. Methylprednisolone 69-87 interleukin 6 Homo sapiens 158-162 9408298-5 1997 Administration of pentoxifylline [PTX] (400 mg/day) to septic patients following necrotizing pancreatitis resulted in TNF and IL-6 production similar to that observed in control donors. Pentoxifylline 18-32 interleukin 6 Homo sapiens 126-130 9408298-5 1997 Administration of pentoxifylline [PTX] (400 mg/day) to septic patients following necrotizing pancreatitis resulted in TNF and IL-6 production similar to that observed in control donors. Pentoxifylline 34-37 interleukin 6 Homo sapiens 126-130 18472839-5 1997 Activation of phospholipase A(2) is suggested by the increase in the stable metabolite of PGI(2) and might be by itself or through lipidic metabolites, a major systemic stimulus of IL-6 and IL-8 production. Epoprostenol 90-96 interleukin 6 Homo sapiens 181-185 8981203-8 1996 Moreover, intragraft interleukin-4 and interleukin-6 mRNA transcripts were hardly detectable (both 17%) in methylprednisolone-reversible rejections, but in ongoing rejections interleukin-4 mRNA expression was found in 62% (p = 0.14), and interleukin-6 was found in 88% of the endomyocardial biopsy specimens (p = 0.03). Methylprednisolone 107-125 interleukin 6 Homo sapiens 39-52 8768854-8 1996 Type I patients, given methimazole (30 mg/day) and potassium perchlorate (1 g/day), achieved normal free T3 and IL-6 concentrations after an average of 4 weeks. Methimazole 23-34 interleukin 6 Homo sapiens 112-116 8768854-8 1996 Type I patients, given methimazole (30 mg/day) and potassium perchlorate (1 g/day), achieved normal free T3 and IL-6 concentrations after an average of 4 weeks. potassium perchlorate 51-72 interleukin 6 Homo sapiens 112-116 8880895-0 1996 Inhibitory effects of interleukin-6 on release of PGI2 by cultured human pulmonary artery smooth muscle cells. Epoprostenol 50-54 interleukin 6 Homo sapiens 22-35 8880895-1 1996 We evaluated the effect of interleukin-6 (IL-6) on the production of prostacyclin (PGI2) by cultured human pulmonary artery smooth muscle cells (HPASMC). Epoprostenol 69-81 interleukin 6 Homo sapiens 27-40 8880895-1 1996 We evaluated the effect of interleukin-6 (IL-6) on the production of prostacyclin (PGI2) by cultured human pulmonary artery smooth muscle cells (HPASMC). Epoprostenol 69-81 interleukin 6 Homo sapiens 42-46 8880895-1 1996 We evaluated the effect of interleukin-6 (IL-6) on the production of prostacyclin (PGI2) by cultured human pulmonary artery smooth muscle cells (HPASMC). Epoprostenol 83-87 interleukin 6 Homo sapiens 27-40 8880895-1 1996 We evaluated the effect of interleukin-6 (IL-6) on the production of prostacyclin (PGI2) by cultured human pulmonary artery smooth muscle cells (HPASMC). Epoprostenol 83-87 interleukin 6 Homo sapiens 42-46 8880895-2 1996 Incubation of these cells for up to 48 h with IL-6 led to a dose- and time-dependent decrease in the concentration of PGI2 in the culture medium. Epoprostenol 118-122 interleukin 6 Homo sapiens 46-50 8797110-0 1996 Herbimycin A, a tyrosine kinase inhibitor, impairs hypercalcemia associated with a human squamous cancer producing interleukin-6 in nude mice. herbimycin 0-12 interleukin 6 Homo sapiens 115-128 8797110-5 1996 Intraperitoneal administration (once a day for 2 days) of herbimycin A to cancer-bearing hypercalcemic mice reduced the plasma levels of human IL-6 and impaired the hypercalcemia. herbimycin 58-70 interleukin 6 Homo sapiens 143-147 8797110-9 1996 Herbimycin A suppressed the tyrosine autophosphorylation of EGFR and IL-6 mRNA expression and production, all of which were stimulated by EGF. herbimycin 0-12 interleukin 6 Homo sapiens 69-73 8973087-9 1996 CONCLUSIONS: Initial elevation of IL-6 concentration might induce stress hormones such as norepinephrine and glucagon, but not insulin after surgical trauma. Glucagon 109-117 interleukin 6 Homo sapiens 34-38 8843590-0 1996 15-Deoxyspergualin inhibits interleukin 6 production in in vitro stimulated human lymphocytes. gusperimus 0-18 interleukin 6 Homo sapiens 28-41 8613948-6 1996 Budesonide (10(-7) M) dramatically reduced A-PBM proliferation (measured by 3H-thymidine incorporation) and cytokine (IL-1beta, IL-2, IL-6, IFN-gamma, TNF-alpha) production, but was not cytotoxic to immune cells. Budesonide 0-10 interleukin 6 Homo sapiens 134-138 8819095-10 1996 Plasma levels of the inflammatory cytokines tumour necrosis factor (TNF) and interleukin-6 (IL-6) are increased in NEC and in magnesium deficiency; these experimentally produce shock and tissue injury, especially of the intestine. Magnesium 126-135 interleukin 6 Homo sapiens 77-90 8819095-10 1996 Plasma levels of the inflammatory cytokines tumour necrosis factor (TNF) and interleukin-6 (IL-6) are increased in NEC and in magnesium deficiency; these experimentally produce shock and tissue injury, especially of the intestine. Magnesium 126-135 interleukin 6 Homo sapiens 92-96 8890995-6 1996 Intra-operative use of methylprednisolone, which is known to block the production and action of cytokines, suppressed the increase in IL-6 levels after surgery. Methylprednisolone 23-41 interleukin 6 Homo sapiens 134-138 8853224-1 1996 OBJECTIVE: To investigate the effects of desferrioxamine (DFO) infusion on chronic disease anemia (CDA) of rheumatoid arthritis (RA) by evaluating interleukin-6 (IL-6) and erythropoietin (EPO) production. Deferoxamine 58-61 interleukin 6 Homo sapiens 147-160 8853224-1 1996 OBJECTIVE: To investigate the effects of desferrioxamine (DFO) infusion on chronic disease anemia (CDA) of rheumatoid arthritis (RA) by evaluating interleukin-6 (IL-6) and erythropoietin (EPO) production. Deferoxamine 58-61 interleukin 6 Homo sapiens 162-166 7473176-0 1995 Effects of methylprednisolone and 21-aminosteroids on mitogen-induced interleukin-6 and tumor necrosis factor-alpha production in human peripheral blood mononuclear cells. Methylprednisolone 11-29 interleukin 6 Homo sapiens 70-115 7561108-15 1995 Our data also suggest that a herbimycin-sensitive step, presumably a tyrosine kinase, is involved in mediating LPS-induced human EC activation and IL-6 secretion. herbimycin 29-39 interleukin 6 Homo sapiens 147-151 8589669-1 1995 Five high molecular weight glycolipids capable of stimulating human peripheral whole-blood cell cultures to cause interleukin 6 (IL-6) and tumor necrosis factor (TNF)-alpha induction were isolated from one of the lipoteichoic acid fractions (LTA-2) extracted from Enterococcus hirae ATCC 9790 (Tsutsui et al., (1991) FEMS Microbiol. Glycolipids 27-38 interleukin 6 Homo sapiens 114-127 8589669-1 1995 Five high molecular weight glycolipids capable of stimulating human peripheral whole-blood cell cultures to cause interleukin 6 (IL-6) and tumor necrosis factor (TNF)-alpha induction were isolated from one of the lipoteichoic acid fractions (LTA-2) extracted from Enterococcus hirae ATCC 9790 (Tsutsui et al., (1991) FEMS Microbiol. Glycolipids 27-38 interleukin 6 Homo sapiens 129-133 7609845-7 1995 In addition, it has been reported that IL-6 inhibits prostaglandin I2 production and increases the mRNA level of c-sis gene, suggesting that IL-6 may play an important role in vasospasm as vasoconstrictor. Epoprostenol 53-69 interleukin 6 Homo sapiens 39-43 7609845-7 1995 In addition, it has been reported that IL-6 inhibits prostaglandin I2 production and increases the mRNA level of c-sis gene, suggesting that IL-6 may play an important role in vasospasm as vasoconstrictor. Epoprostenol 53-69 interleukin 6 Homo sapiens 141-145 7738074-3 1995 On day 1, the neutral surface FEP polymer with incorporated amide (NH2) groups showed the greatest inhibition of adhesion, 89% (P < .01), and cytokine production (IL-1 beta with 58%, IL-6 with 70%, and TNF-alpha with 39%) compared to control TCPS. Amides 60-65 interleukin 6 Homo sapiens 186-190 7587649-10 1995 Cultured meningioma cells react to octreotide with a stimulation in growth, possibly by interference with the autocrine inhibitory growth control by interleukin 6. Octreotide 35-45 interleukin 6 Homo sapiens 149-162 8553904-7 1995 Moreover, neopterin concentrations were significantly correlated with those of IL-6. Neopterin 10-19 interleukin 6 Homo sapiens 79-83 7623608-2 1995 Myo-inositol incorporation into HSF was dependent on an active transport system via Na(+)-K+ ATPase activity based on the results with Na+ deprivation and ouabain (5 mM). Inositol 0-12 interleukin 6 Homo sapiens 32-35 7527006-3 1994 In cultured rat hepatocytes, recombinant human interleukin-6, added simultaneously with glucagon and insulin, lowered the maximal increase in glucagon-induced phosphoenolpyruvate carboxykinase mRNA levels after 2 hr and the maximal increase in glucokinase mRNA levels after 3 hr to about 30%, respectively. Glucagon 88-96 interleukin 6 Homo sapiens 47-60 7527006-6 1994 Recombinant human interleukin-6, added 2 hr after glucagon or 3 hr after insulin at the maximum of the hormone-induced enzyme mRNA levels, almost doubled the decay rate of phosphoenolpyruvate carboxykinase mRNA and glucokinase mRNA. Glucagon 50-58 interleukin 6 Homo sapiens 18-31 7524649-6 1994 DHA also limited cytokine-stimulated endothelial cell expression of E-selectin and intercellular adhesion molecule 1 and the secretion of IL-6 and IL-8 into the medium but not the surface expression of constitutive surface molecules. Docosahexaenoic Acids 0-3 interleukin 6 Homo sapiens 138-142 7829685-2 1994 The study was designed to determine whether the expected interleukin 6 increases after surgery are the cause of decreased serum tri-iodothyronine (T3) concentration normally observed following severe trauma. Triiodothyronine 128-145 interleukin 6 Homo sapiens 57-70 7829685-2 1994 The study was designed to determine whether the expected interleukin 6 increases after surgery are the cause of decreased serum tri-iodothyronine (T3) concentration normally observed following severe trauma. Triiodothyronine 147-149 interleukin 6 Homo sapiens 57-70 7914487-4 1994 Subsequent dimerisation of these intermediate forms into 16-kDa IL-6- and 14-kDa IGF-1-derived peptides was inhibited by acivicin and glutathione which are specific inhibitors of the standard cell-surface gamma-glutamyl transpeptidase (gamma-GT). acivicin 121-129 interleukin 6 Homo sapiens 64-68 8064732-5 1994 RESULTS: Piroxicam treatment resulted in elevation of levels of IL-2, depression of IL-1, IL-6, TNF alpha and IFN-gamma, and no consistent effect on IL-4. Piroxicam 9-18 interleukin 6 Homo sapiens 90-94 7914751-5 1994 Addition of exogenous AZA, 6-mercaptopurine (6-MP), and MTX to the IL-6 bioassay resulted in a dose-dependent inhibition of the B9 cell proliferation induced by IL-6, AZA being most potent on a molar basis. Azathioprine 22-25 interleukin 6 Homo sapiens 67-71 2546751-4 1989 In monolayers of HSF, replacing 120 mM NaCl with isoosmotic concentrations of sucrose increases binding of [125I]IGF-I by 2- to 6-fold. Sucrose 78-85 interleukin 6 Homo sapiens 17-20 7914751-5 1994 Addition of exogenous AZA, 6-mercaptopurine (6-MP), and MTX to the IL-6 bioassay resulted in a dose-dependent inhibition of the B9 cell proliferation induced by IL-6, AZA being most potent on a molar basis. Azathioprine 22-25 interleukin 6 Homo sapiens 161-165 2572101-6 1989 During therapy with MC 903 a decline in the staining intensity for IL-6, but not for TNF alpha, was observed in both lesional and unaffected skin. Methylcholanthrene 20-22 interleukin 6 Homo sapiens 67-71 2476083-8 1989 Both dexamethasone and 13-cis-RA also reduced the mRNA level of glyceraldehyde-3-phosphate dehydrogenase, indicating that glucocorticoids and retinoids have both similar and different effects on gene expression in HSF. 13-cis-ra 23-32 interleukin 6 Homo sapiens 214-217 7914751-5 1994 Addition of exogenous AZA, 6-mercaptopurine (6-MP), and MTX to the IL-6 bioassay resulted in a dose-dependent inhibition of the B9 cell proliferation induced by IL-6, AZA being most potent on a molar basis. Azathioprine 167-170 interleukin 6 Homo sapiens 67-71 7914751-8 1994 This study shows that circulating AZA (or its metabolites) exert an inhibitory effect in the IL-6 bioassay. Azathioprine 34-37 interleukin 6 Homo sapiens 93-97 8130057-0 1994 Suppression by methylprednisolone of augmented plasma endotoxin-like activity and interleukin-6 during cardiopulmonary bypass. Methylprednisolone 15-33 interleukin 6 Homo sapiens 82-95 3917482-1 1985 Stimulation of human B lymphoblastoid cell lines, CESS and SKW6-CL4 with BCDF induced an increase in IgG- and IgM-secreting cells, as well as a slight increase in IgG and IgM expression on their respective surfaces. skw6-cl4 59-67 interleukin 6 Homo sapiens 73-77 2456923-6 1988 A cDNA containing the coding sequence for interleukin-6 (B-cell stimulatory factor 2, interferon-beta 2/26-kDa protein, interleukin HP1) derived from human T-cells cloned into the transcription vector pGEM4 was transcribed in vitro. pgem4 201-206 interleukin 6 Homo sapiens 42-55 3278321-7 1988 A single 24-kDa band with CDF activity is then isolated on 12% NaDodSO4/PAGE and clearly distinguished from the 17-kDa band of IL-2. nadodso4 63-71 interleukin 6 Homo sapiens 26-29 6573232-0 1983 Augmentation of prostaglandin and thromboxane production in vitro by monocytes exposed to histamine-induced suppressor factor (HSF). Thromboxanes 34-45 interleukin 6 Homo sapiens 90-125 8130057-3 1994 We found that methylprednisolone suppressed significantly the ECC-induced increases in plasma endotoxin, measured by a conventional Limulus amoebocyte lysate assay (Toxicolor), and interleukin-6. Methylprednisolone 14-32 interleukin 6 Homo sapiens 181-194 6573232-0 1983 Augmentation of prostaglandin and thromboxane production in vitro by monocytes exposed to histamine-induced suppressor factor (HSF). Thromboxanes 34-45 interleukin 6 Homo sapiens 127-130 8003851-8 1994 When added to the BM cultures concomitantly with LPS, budesonide suppressed IL-1 beta and IL-6 only partially (to 30% of the control level). Budesonide 54-64 interleukin 6 Homo sapiens 90-94 33857595-13 2021 Furthermore, isoorientin, orientin, isovitexin, and vitexin produced significant concentration-dependent inhibition with IC50 values (muM) of COX-2: 7.13, 9.51, 12.81, 16.61; IL-1beta 4.80, 6.20, 10.85, 14.51; IL-6: 4.01, 5.90, 11.51 and 14.88 as compared to dexamethasone: 5.29, 2.93, 3.72, respectively (p<0.05). isovitexin 36-46 interleukin 6 Homo sapiens 210-214 3023045-5 1986 Two IFN-beta 2 genomic clones were isolated and their expression in hamster and mouse cells also produces biologically active rIFN-beta 2. rifn-beta 2 126-137 interleukin 6 Homo sapiens 4-14 8132219-4 1994 Of the various cytokines tested, interleukin-4 (IL-4) reduced the NES-induced inhibition of Ig production, whereas other cytokines, including IL-1 beta, IL-2, IL-3, IL-5, IL-6, interferon-alpha (IFN-alpha), IFN-gamma, granulocyte-macrophage colony-stimulating factor (GM-CSF) and erythropoietin (Epo) failed to do so. Nedocromil 66-69 interleukin 6 Homo sapiens 171-175 34036453-15 2021 Long-term chronic exposure to 3-NBA upregulates the levels of tumor-promoting genes such as EREG and IL-6. 3-nba 30-35 interleukin 6 Homo sapiens 101-105 34055821-11 2021 Correlation analyses showed that changes in oxylipins were positively correlated with serum levels of IL-6 and C-reactive protein. Oxylipins 44-53 interleukin 6 Homo sapiens 102-106 34023435-7 2021 tBHQ further activated Nrf2 and promoted the expression of IL-17D, IL-6, and IL-4. 2-tert-butylhydroquinone 0-4 interleukin 6 Homo sapiens 67-71 33998846-7 2021 Also, only lycopene (WMD: -1.08 pg/ml, 95%CI: -2.03, -0.12, P = 0.027) led to a significant decrease in IL-6. Lycopene 11-19 interleukin 6 Homo sapiens 104-108 8165444-0 1994 The effect of azathioprine on serum levels of interleukin 6 and soluble interleukin 2 receptor. Azathioprine 14-26 interleukin 6 Homo sapiens 46-94 34001091-8 2021 Time course studies showed that ORMDL3-deficient A549 and NHBE cells had an attenuated IL-6 and IL-8 response to poly I:C stimulation. Poly I-C 113-121 interleukin 6 Homo sapiens 87-91 34001091-9 2021 A549 and NHBE cells over-expressing ORMDL3 released relatively more IL-6 and IL-8 following poly I:C stimulation. Poly I-C 92-100 interleukin 6 Homo sapiens 68-72 34025636-5 2021 Importantly, when applied in combination with PA, the PA-induced lipid accumulation was decreased and the cells secreted increased IL6 levels. Palmitic Acid 46-48 interleukin 6 Homo sapiens 131-134 8165444-3 1994 This study addressed the effect of AZA on serum IL-6 and soluble IL-2 receptor (sIL-2R) levels in RA. Azathioprine 35-38 interleukin 6 Homo sapiens 48-52 8264156-5 1993 In contrast, IL-6 pretreatment partially abrogated the effect of LPS on albumin excretion (NTAb 4 +/- 2; LPS/NTAb 85 +/- 11 and IL-6/LPS/NTAb 32 +/- 6 mg/24 hr, P < 0.002), percentage of glomerular capillary thrombi (3 +/- 1%; 39 +/- 8%; and 6 +/- 1%, P < 0.001) and glomerular neutrophil infiltrate (29 +/- 3; 58 +/- 5; and 34 +/- 2 neutrophils/50 glomeruli in section, P < 0.001, respectively) at 24 hours. nitrophenyl N-oluenesulfonyl-aminoisobutyrate 91-95 interleukin 6 Homo sapiens 13-17 33636560-9 2021 Molecular analyses indicated that the protection mediated by L-Ctl against LPS-evoked sepsis targeted the TLR4/ERK/JNK/p38-MAPK pathway, regulating NFkB p65, NFkB p52 and COX2 expression and repressing the mRNA expression levels of the LPS-induced proinflammatory factors IL-1beta, IL-6, TNF-alpha and NOS2. l-ctl 61-66 interleukin 6 Homo sapiens 282-286 33977953-7 2021 Furthermore, hesperetin suppressed NF-kappaB activation and reduced inflammatory cytokine secretion (TNF-alpha and IL-6). hesperetin 13-23 interleukin 6 Homo sapiens 115-119 8264156-5 1993 In contrast, IL-6 pretreatment partially abrogated the effect of LPS on albumin excretion (NTAb 4 +/- 2; LPS/NTAb 85 +/- 11 and IL-6/LPS/NTAb 32 +/- 6 mg/24 hr, P < 0.002), percentage of glomerular capillary thrombi (3 +/- 1%; 39 +/- 8%; and 6 +/- 1%, P < 0.001) and glomerular neutrophil infiltrate (29 +/- 3; 58 +/- 5; and 34 +/- 2 neutrophils/50 glomeruli in section, P < 0.001, respectively) at 24 hours. nitrophenyl N-oluenesulfonyl-aminoisobutyrate 109-113 interleukin 6 Homo sapiens 13-17 8264156-5 1993 In contrast, IL-6 pretreatment partially abrogated the effect of LPS on albumin excretion (NTAb 4 +/- 2; LPS/NTAb 85 +/- 11 and IL-6/LPS/NTAb 32 +/- 6 mg/24 hr, P < 0.002), percentage of glomerular capillary thrombi (3 +/- 1%; 39 +/- 8%; and 6 +/- 1%, P < 0.001) and glomerular neutrophil infiltrate (29 +/- 3; 58 +/- 5; and 34 +/- 2 neutrophils/50 glomeruli in section, P < 0.001, respectively) at 24 hours. nitrophenyl N-oluenesulfonyl-aminoisobutyrate 109-113 interleukin 6 Homo sapiens 13-17 33963832-9 2021 It is anticipated that StackIL6 can help to facilitate rapid screening of promising IL-6 inducing peptides for the development of diagnostic and immunotherapeutic applications in the future. stackil6 23-31 interleukin 6 Homo sapiens 84-88 33900308-6 2021 Syringic acid and kuromanin, standard compounds found in FBBBR, significantly decreased the interleukin (IL)-1beta, IL-6 and IL-8 levels in PM2.5-treated HaCaT cells. syringic acid 0-13 interleukin 6 Homo sapiens 116-120 8409748-2 1993 A-63162 inhibited PBMC proliferation stimulated by phytohemagglutinin (PHA) and phorbol myristate acetate (PMA) plus A23187, IL-2 receptor expression stimulated by PHA, and IL-2 or IL-6 synthesis induced by PHA plus PMA or PMA plus A23187. N-hydroxy-N-(1-(4-(phenylmethoxy)phenyl)ethyl)-acetamide 0-7 interleukin 6 Homo sapiens 181-185 33963719-8 2021 Several key targets including AKT1, IL- 6, JUN, TNF and CASP3 were screened for molecular docking, which had good binding activities with berberrubine, epiberberine, stigmasterol and sitosterol. Stigmasterol 166-178 interleukin 6 Homo sapiens 36-41 33936205-8 2021 Consequently, the bisulfite-modified DNA was used to confirm the methylation status of the IL6 gene promoter through the pyrosequencing method. hydrogen sulfite 18-27 interleukin 6 Homo sapiens 91-94 33958662-5 2021 Exogenous 11,12-EET and 19,20-EDP significantly decreased PA- and IL-1beta-induced MC expression of IL-1beta and IL-6. Palmitic Acid 58-60 interleukin 6 Homo sapiens 113-117 33998900-7 2021 Results: Tumor necrosis factor alpha, interleukin (IL)-1beta, IL-6, and interferon gamma were the most commonly studied pro-inflammatory cytokines and their levels were consistently reduced after treatment with CBD, CBG, or CBD+THC, but not with THC alone. Cannabidiol 211-214 interleukin 6 Homo sapiens 62-66 8409748-3 1993 At the same concentration, A-63162 inhibited accumulation of mRNA for IL-2 or IL-6 and also inhibited leukotriene B4 (LTB4) synthesis. N-hydroxy-N-(1-(4-(phenylmethoxy)phenyl)ethyl)-acetamide 27-34 interleukin 6 Homo sapiens 78-82 8409748-4 1993 Our data indicate that the 5-LO inhibitor A-63162 has immunosuppressive activity that may be due to inhibition of LTB4 production or to direct inhibitory actions of A-63162 on IL-2 and IL-6 synthesis. N-hydroxy-N-(1-(4-(phenylmethoxy)phenyl)ethyl)-acetamide 42-49 interleukin 6 Homo sapiens 185-189 33508280-9 2021 In addition, COP treatment remarkably suppressed the levels of colonic myeloperoxidase (MPO), adhesion molecules and pro-inflammatory cytokines (TNF-alpha, IFN-gamma, IL-1beta, IL-6 and IL-17), while enhanced IL-10 and TGF-beta. coptisine 13-16 interleukin 6 Homo sapiens 177-181 33905318-12 2021 A positive association was detected between miR-142-5p and serum levels of IL-6, TNF-alpha in SCI patients. mir-142-5p 44-54 interleukin 6 Homo sapiens 75-79 8409748-4 1993 Our data indicate that the 5-LO inhibitor A-63162 has immunosuppressive activity that may be due to inhibition of LTB4 production or to direct inhibitory actions of A-63162 on IL-2 and IL-6 synthesis. N-hydroxy-N-(1-(4-(phenylmethoxy)phenyl)ethyl)-acetamide 165-172 interleukin 6 Homo sapiens 185-189 33549578-6 2021 Data from the enzyme-linked immunosorbent assay (ELISA) showed that both coelonin (10 and 20 mug/ml) and militarine (5 and 10 mug/ml) mitigated PM2.5-induced inflammation by reducing the generation of inflammatory factors, including interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha). coelonin 73-81 interleukin 6 Homo sapiens 233-246 33549578-6 2021 Data from the enzyme-linked immunosorbent assay (ELISA) showed that both coelonin (10 and 20 mug/ml) and militarine (5 and 10 mug/ml) mitigated PM2.5-induced inflammation by reducing the generation of inflammatory factors, including interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha). coelonin 73-81 interleukin 6 Homo sapiens 248-252 33578085-8 2021 The colloidal mercuric formulation upregulated the expression of TGF-beta, IL-6 and TNF-alpha, due to the presence of arsenic and other organic compounds such as piperine. Arsenic 118-125 interleukin 6 Homo sapiens 75-79 33900421-4 2021 IL6-174 GC and IL8-251 T allele showed a protective effect in women against ACG development and, conversely, IL8-251 polymorphism showed a risk for men. acg 76-79 interleukin 6 Homo sapiens 0-3 1334783-9 1992 Subsequently, we investigated the capacity of nedocromil to affect the capacity of IgE plus anti-IgE complexes, allergen, and LPS (16 hr/37 degrees C) to stimulate IL-1 beta and IL-6 production. Nedocromil 46-56 interleukin 6 Homo sapiens 178-182 33880765-7 2021 Interestingly, ZnFe2 O4 and CrFe2 O4 nanoparticles revealed an excellent anti-inflammatory activity by dose-dependently suppressing mRNA expressions of IL-1b, IL-6, and TNF-alpha. znfe2 o4 15-23 interleukin 6 Homo sapiens 159-163 33880765-7 2021 Interestingly, ZnFe2 O4 and CrFe2 O4 nanoparticles revealed an excellent anti-inflammatory activity by dose-dependently suppressing mRNA expressions of IL-1b, IL-6, and TNF-alpha. crfe2 o4 28-36 interleukin 6 Homo sapiens 159-163 33937285-5 2021 Among such class of drugs, azithromycin is described as azalide and is well-known for its ability to decrease the production of pro-inflammatory cytokines, including matrix metalloproteinases, tumor necrosis factor-alpha, interleukin (IL)-6, and IL-8. azalide 56-63 interleukin 6 Homo sapiens 222-240 33639176-7 2021 Baricitinib did modulate other soluble factors besides IFN-gamma, significantly decreasing the spike-specific-response mediated by IL-17, IL-1beta, IL-6, TNF-alpha, IL-4, IL-13, IL-1ra, IL-10, GM-CSF, FGF, IP-10, MCP-1, MIP-1beta (p <= 0.0156). baricitinib 0-11 interleukin 6 Homo sapiens 148-152 33748269-13 2021 The findings also suggest that several ingredients of ABR such as Baicalien, Copistine, Epiberberine, Kaempferol, and Palmatine have good affinity with IL6, suggesting the promising potential of ABR in treating bone trauma, likely through IL6. baicalien 66-75 interleukin 6 Homo sapiens 152-155 33665756-1 2021 Acid sphingomyelinase (ASM) and acid beta-glucosidase 1 (GBA1) catalyze ceramide formation through different routes, and both are involved in rheumatoid arthritis (RA) pathogenesis as well as IL-6 production. Ceramides 72-80 interleukin 6 Homo sapiens 192-196 1956868-4 1991 The inhibitory potency of AR 12456 in HSF was enhanced after preincubation of the drug with Hep G2 and removal of the medium to HSF, suggesting that the formed metabolite(s) are more potent inhibitors than the parent substance. AR 12456 26-34 interleukin 6 Homo sapiens 38-41 33665756-6 2021 GBA1 and ceramide serum levels were negatively and positively correlated with IL-6 serum level in RA patients, respectively. Ceramides 9-17 interleukin 6 Homo sapiens 78-82 33898438-4 2021 We found that prednisolone treatment reduced hESF cytokine expression (IL6, IL11, IL18, LIF, and LIFR) but had no effect on hESF expression or secretion of the classic markers of decidualization [prolactin (PRL) and IGFBP1]. Prednisolone 14-26 interleukin 6 Homo sapiens 71-74 1956868-4 1991 The inhibitory potency of AR 12456 in HSF was enhanced after preincubation of the drug with Hep G2 and removal of the medium to HSF, suggesting that the formed metabolite(s) are more potent inhibitors than the parent substance. AR 12456 26-34 interleukin 6 Homo sapiens 128-131 1885209-4 1991 1,25-(OH)2D3 and the analogue MC 903 inhibited IL-6 production by LPS-stimulated human mononuclear cells. calcipotriene 30-36 interleukin 6 Homo sapiens 47-51 33045823-11 2021 The results of statistical analysis showed that vitamin K1 and K2 levels were correlated with TNF-alpha, IL-1beta and IL-6 levels. Vitamin K 1 48-58 interleukin 6 Homo sapiens 118-122 2236903-2 1990 Single organic- and water-soluble metabolites increased with BaP concentration in both types of HSF, but the ratio normal/variant increased with BaP concentration. Benzo(a)pyrene 61-64 interleukin 6 Homo sapiens 96-99 33541663-5 2021 6-Carboxyl chitins could stimulate significantly the proliferation of human skin fibroblasts (HSF) and human keratinocytes (HaCaT), and the bioactivities were concentration and Mws dependent. 6-carboxyl chitins 0-18 interleukin 6 Homo sapiens 94-97 2252806-6 1990 IL-6 production was significantly reduced in the presence of Cuprophan (151 +/- 45 pg/ml), Hemophan (167 +/- 6 pg/ml), and polyacrylonitrile (108 +/- 33 pg/ml) when compared with polystyrole (724 +/- 34 pg/ml). polystyrole 179-190 interleukin 6 Homo sapiens 0-4 33400188-4 2021 Induction of remission by prednisolone reduced expression levels not only of Th2 cytokines but also of IL-6 and TNF-alpha in the GI mucosa. Prednisolone 26-38 interleukin 6 Homo sapiens 103-107 33071012-9 2021 C-reactive protein was lower 4 h postprandially in the anthocyanins (1.80 mg/L, IQR 0.90) vs control arm (2.30 mg/L, IQR 1.95) (P = 0.026), accompanied by a trend for lower concentrations of interleukin-6 (P = 0.075). Anthocyanins 55-67 interleukin 6 Homo sapiens 191-204 20233899-7 2010 Deletion of STAT2 decreased azoxymethane/dextran sodium sulfate-induced expression and release of proinflammatory mediators, such as interleukin-6 and CCL2, and decreased interleukin-6 release from skin carcinoma cells, which then decreased STAT3 activation. dextran sodium sulfate 41-63 interleukin 6 Homo sapiens 133-146 33600572-0 2021 Expression of Concern: Cajanonic acid A regulates the ratio of Th17/Treg via inhibition of expression of IL-6 and TGF-beta in insulin-resistant HepG2 cells. cajanonic acid a 23-39 interleukin 6 Homo sapiens 105-109 33517222-9 2021 In addition, empagliflozin treatment and downregulation of SGLT-2 expression reduced the levels of inflammatory cytokines (TNF-alpha, IL-1beta, IL-6), TGF-beta1, alpha-smooth muscle actin, collagen I, and p-Smad3 accumulation in human peritoneal mesothelial cells. empagliflozin 13-26 interleukin 6 Homo sapiens 144-148 9860036-8 1998 Within-treatment comparisons suggested that mometasone furoate reduced the antigen-induced late-phase response for IL-6, IL-8, and eosinophils compared with pretreatment. Mometasone Furoate 44-62 interleukin 6 Homo sapiens 115-119 33760324-5 2021 In addition, miR-512-3p enriched by MSCs- derived exosomes markedly inhibited ox-LDL-mediated EC damage, namely, accelerated EC proliferation, inhibited Caspase-3 activation and cell apoptosis, inhibited the levels of inflammatory cytokines (tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-6) and oxidative factor MDA, and increased the contents of SOD and GSH-PX. mir-512-3p 13-23 interleukin 6 Homo sapiens 299-303 33599317-13 2022 IL-6 induction was decreased by pretreatment of cells with NF-kappaB inhibitor SN50 or p38 MAPK inhibitor SB203580, while CCL2 induction was reduced by SN50 or JNK inhibitor SP600125. SB 203580 106-114 interleukin 6 Homo sapiens 0-4 9860036-11 1998 CONCLUSION: These results suggest that the clinical activity of mometasone furoate nasal spray in seasonal allergic rhinitis is likely due, in part, to a reduction in the levels of histamine in nasal secretions related to the early phase response, and reductions in IL-6, IL-8, and eosinophils during the late phase response. Mometasone Furoate 64-82 interleukin 6 Homo sapiens 266-270 33583094-7 2021 Interestingly, when keratinocytes were stimulated with a TLR3 agonist, RGRN-305 also demonstrated potent immunomodulatory effects, significantly inhibiting poly(I:C)-induced expression of the proinflammatory genes TNFalpha, IL1B, IL6, and IL23A. Poly I-C 156-165 interleukin 6 Homo sapiens 230-233 33790807-6 2021 Induction of IL-6, IL-8, and ICAM-1 synthesis from cultured PTECs incubated with IgA-HMC conditioned medium was significantly suppressed by treatment with the Syk inhibitor R406 compared to that from healthy control. R406 173-177 interleukin 6 Homo sapiens 13-17 34369110-11 2022 Sputum-induced cit-H3+ NET formation also correlated with sputum IL-1beta, IL-6 and TNF-alpha levels in At-Risk subjects, suggesting a causal relationship. HS 3 19-22 interleukin 6 Homo sapiens 75-79 33599556-8 2021 VPA was inversely associated with hs-CRP, leptin, and IL-6 in children with higher BF% (beta=-0.344 to -0.181, 95% CI=-0.477 to -0.033) but not among children with lower BF% (beta=-0.007 to 0.033, 95% CI=-0.183 to 0.184). VALPROIC ACID 0-3 interleukin 6 Homo sapiens 54-58 33598470-10 2021 For CTP values, we found significant positive associations with IP-10 (q-value = 0.010), IL-6 (q-value = 0.010), IL-1RA (q-value = 0.033), and sICAM-1 (q-value = 0.010). Cytidine Triphosphate 4-7 interleukin 6 Homo sapiens 89-93 34815622-4 2022 Epigallocatechin-3-gallate - a polyphenol from tea - effectively has been shown to inhibit the activity of SARS-CoV-2 as it blocked binding of coronavirus 2 to human angiotensin converting enzyme 2, decreased the expression of inflammatory factors in the blood, including tumor necrosis factor-alpha and interleukin-6, and significantly increased the overall fertilization efficiency in animals. Polyphenols 31-41 interleukin 6 Homo sapiens 304-317 33496895-9 2021 In H/R liver cells, PRO promoted the cell viability, downregulated the levels of LDH, MDA, TNF-alpha, IL-6, and reduced ROS production. Propofol 20-23 interleukin 6 Homo sapiens 102-106 33708102-6 2021 The Poly I:C treatment induced the expression and secretion of different cytokines belonging to the CCL- and CXCL-motif chemokine family as well as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha). Poly I-C 4-12 interleukin 6 Homo sapiens 148-161 33708102-6 2021 The Poly I:C treatment induced the expression and secretion of different cytokines belonging to the CCL- and CXCL-motif chemokine family as well as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha). Poly I-C 4-12 interleukin 6 Homo sapiens 163-167 33052714-7 2021 In vitro, IL-6 induced proliferation and migration of HPASMCs from healthy individuals as well as from IPAH patients were reduced in a dose-dependent manner by the FDA-approved Jak1 and Jak2 inhibitor ruxolitinib. ruxolitinib 201-212 interleukin 6 Homo sapiens 10-14 34890370-5 2021 RESULTS: In all studied women, the levels of IL-1beta significantly positively correlated with Ca, Mg, and Sr; IFNgamma significantly negatively correlated with Sr, and IL-6 with Mg. Magnesium 179-181 interleukin 6 Homo sapiens 169-173 33938176-0 2021 HDAC8 promotes daunorubicin resistance of human acute myeloid leukemia cells via regulation of IL-6 and IL-8. Daunorubicin 15-27 interleukin 6 Homo sapiens 95-99 33938176-4 2021 While recombinant IL-6 (rIL-6) and rIL-8 can reverse si-HDAC8-resored DNR sensitivity of AML cells. Daunorubicin 70-73 interleukin 6 Homo sapiens 18-22 33501560-6 2021 The present study reports that smokers carrying GA for IL-6 - 596 G/A were at several folds higher risk of developing oral precancerous lesions. Gallium 48-50 interleukin 6 Homo sapiens 55-59 34890370-9 2021 The levels of IL-6 negatively correlated with Ca and Mg. Magnesium 53-55 interleukin 6 Homo sapiens 14-18 33938176-7 2021 Collectively, our data suggested that HDAC8 promotes DNR resistance of human AML cells via regulation of IL-6 and IL-8. Daunorubicin 53-56 interleukin 6 Homo sapiens 105-109 34944489-8 2021 Although EGCG did not reduce (e)Abeta42, the polyphenol reversed Ca2+ influx dysregulation as a response to acetylcholine (ACh) stimuli in PSEN1 E280A ChLNs, inhibited the activation of transcription factor NF-kappaB, and reduced the secretion of pro-inflammatory IL-6 in wild-type astrocyte-like cells (ALCs) when exposed to mutant ChLNs culture supernatant. Polyphenols 45-55 interleukin 6 Homo sapiens 264-268 33113418-9 2020 Here, we summarize the mounting evidence where ASX is shown to exert protective effect by regulating the expression of pro-inflammatory factors IL-1beta, IL-6, IL-8 and TNF-alpha. astaxanthine 47-50 interleukin 6 Homo sapiens 154-158 33359047-11 2021 In short, an animal model of chemically-induced epileptic seizures was used, in which the animals were treated with doses of prednisolone, and these animals presented less severe seizures than the negative control group (saline), in addition to showing decreased levels of pro-inflammatory cytokines IL-6, IL-1beta and TNF-alpha, in the hippocampi and prefrontal cortices, but not the sera. Prednisolone 125-137 interleukin 6 Homo sapiens 300-304 33505216-6 2021 The anti-inflammatory mechanism of GL and GA is realized via cytokines like interferon-gamma, tumor necrotizing factor-alpha, interleukin- (IL-) 1beta, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, and IL-17. Glycyrrhetinic Acid 42-44 interleukin 6 Homo sapiens 164-168 34725715-8 2021 The PKA-specific inhibitor, H89, partially inhibited IL-6 release. N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide 28-31 interleukin 6 Homo sapiens 53-57 33553307-13 2021 The high SPS group was characterized by less genomic aberrations, upregulated IL6-JAK-STAT3 and IL2-STAT5 signaling pathways, increased expression of TIM-3, increased infiltration of regulatory T (Treg) cells and T helper 17 (Th17) cells, and decreased infiltration of M0 macrophages. Sodium phenolsulfonate 9-12 interleukin 6 Homo sapiens 78-81 34537380-15 2021 Lastly, in OA hFLS, HU308 treatment inhibited IL-1beta-induced CCL2, MMP1, MMP3, and IL6 expression and further inhibited TNF-alpha-induced CCL2, MMP1, and GMCSF expression, demonstrating human OA-relevant anti-inflammatory effects by targeting CB2. HU 308 20-25 interleukin 6 Homo sapiens 85-88 33142636-5 2021 Three NPs greatly promoted the expression and secretion of interleukin-6 (IL-6), tumor necrosis factor (TNF-alpha), and interleukin-1beta (IL-1beta) in DC cells: C2,3,6 chitosan sulfate-HACC (C2,3,6-HACC; 200 kDa), C3,6 chitosan sulfate-HACC (C3,6-HACC; 200 kDa) and C6 chitosan sulfate-HACC (C6-HACC; 50 kDa). chitosan sulfate 169-185 interleukin 6 Homo sapiens 59-72 33827102-4 2021 To further elucidate the poly IC-induced signaling pathway, we subjected the cells to RNA interference against IFN-beta and IL-6. Poly I-C 25-32 interleukin 6 Homo sapiens 124-128 32789663-7 2020 Ruxolitinib, a tyrosine kinase inhibitor selective for JAK1, 2, blocks many pro- and anti-inflammatory cytokines including IL6. ruxolitinib 0-11 interleukin 6 Homo sapiens 123-126 32898874-7 2020 However, an inhibitory effect of the identified quercetin-3-O-rhamnoside and its aglycone, quercetin, on the release of IL-8 and IL-6 could not be demonstrated. quercitrin 48-72 interleukin 6 Homo sapiens 129-133 32148148-0 2021 Uric acid-mediated inflammasome activation in IL-6 primed innate immune cells is regulated by baricitinib. baricitinib 94-105 interleukin 6 Homo sapiens 46-50 34771080-0 2021 The Effect of Homocysteine on the Secretion of Il-1beta, Il-6, Il-10, Il-12 and RANTES by Peripheral Blood Mononuclear Cells-An In Vitro Study. Homocysteine 14-26 interleukin 6 Homo sapiens 57-61 32148148-8 2021 Pretreatment with baricitinib, which blocks IL-6 receptor signalling, prevented MSU-induced cleaved caspase-1 or IL-1beta induction in IL-6-primed neutrophils. baricitinib 18-29 interleukin 6 Homo sapiens 44-48 32810392-8 2020 Oxysophocarpine sensitized the Lag-3 immunotherapy effect of CD8+ T cells against HCC in vivo and in vitro by decreasing Fibrinogen-like protein 1 (FGL1) expression through downregulating IL-6-mediated JAK2/STAT3 signaling, whereas Oxysophocarpine treatment had a little effect of CD8+ T cells cytotoxicity function against HCC with PD-1, Tim-3, or TIGIT blockade. oxysophocarpine 0-15 interleukin 6 Homo sapiens 188-192 34771080-6 2021 It has been shown that, in the presence of homocysteine, the secretion of IL-1, IL-6 and RANTES by PBMNCs was increased, whereas IL-10 concentration was significantly lower than that of the supernatant derived from a mitogen-stimulated cell culture without homocysteine. Homocysteine 43-55 interleukin 6 Homo sapiens 80-84 31853779-1 2020 BACKGROUND/AIM: We previously demonstrated that inflammatory cytokine interleukin-6 (IL-6) was produced during cancer progression, worked together with transforming growth factor-beta 1 (TGF-beta1), and induced the epithelial-mesenchymal transition (EMT) with chemo-resistance against gemcitabine (GR) at the invasion front of biliary tract cancers (BTCs). gemcitabine 285-296 interleukin 6 Homo sapiens 70-83 31853779-1 2020 BACKGROUND/AIM: We previously demonstrated that inflammatory cytokine interleukin-6 (IL-6) was produced during cancer progression, worked together with transforming growth factor-beta 1 (TGF-beta1), and induced the epithelial-mesenchymal transition (EMT) with chemo-resistance against gemcitabine (GR) at the invasion front of biliary tract cancers (BTCs). gemcitabine 285-296 interleukin 6 Homo sapiens 85-89 33037138-7 2021 Treatment of immortalized and primary patient PSC/CAF with the Hsp90 inhibitor XL888 decreased IL-6, a key cytokine that orchestrates immune changes in PDAC at the transcript and protein level in vitro. XL 888 79-84 interleukin 6 Homo sapiens 95-99 33355843-13 2021 On its own, SB203580 did not stimulate IL-6 secretion from HFCs; however, it dramatically suppressed the degree of IL-6 release stimulated by TNF-alpha from HFCs. SB 203580 12-20 interleukin 6 Homo sapiens 115-119 34771080-8 2021 Therefore, in our opinion, high-concentration homocysteine affects the progression of atherosclerosis by increasing the secretion of proinflammatory cytokines secreted by PBMNCs, such as Il-1beta, Il-6, RANTES, and by attenuating the secretion of Il-10. Homocysteine 46-58 interleukin 6 Homo sapiens 197-201 33037080-7 2020 Treatment with baricitinib significantly decreased serum IL-12p40 and IL-6 cytokine levels at week 12, which persisted through week 24. baricitinib 15-26 interleukin 6 Homo sapiens 70-74 33037080-9 2020 Baricitinib consistently reduced serum levels of two key cytokines implicated in SLE pathogenesis, IL-12p40 and IL-6. baricitinib 0-11 interleukin 6 Homo sapiens 112-116 34754214-0 2021 Linagliptin Inhibits Interleukin-6 Production Through Toll-Like Receptor 4 Complex and Lipopolysaccharide-Binding Protein Independent Pathway in vitro Model. Linagliptin 0-11 interleukin 6 Homo sapiens 21-34 32645631-8 2020 Baricitinib decreased the systemic inflammation by lowering expression of IL-6 and CRP and reducing ESR and serum concentrations of adiponectin. baricitinib 0-11 interleukin 6 Homo sapiens 74-78 33317160-7 2020 Consistent improvements from anthocyanin intake were found in glycemic, gastric inhibitory peptide (GIP), interleukin-6 (IL-6), and oxygen radical absorbance capacity (ORAC) responses. Anthocyanins 29-40 interleukin 6 Homo sapiens 106-119 33317160-7 2020 Consistent improvements from anthocyanin intake were found in glycemic, gastric inhibitory peptide (GIP), interleukin-6 (IL-6), and oxygen radical absorbance capacity (ORAC) responses. Anthocyanins 29-40 interleukin 6 Homo sapiens 121-125 34754214-10 2021 Linagliptin suppressed LPS-induced IL-6 production in a concentration-dependent manner in the presence of FBS. Linagliptin 0-11 interleukin 6 Homo sapiens 35-39 34754214-11 2021 However, only 100 nM linagliptin could suppress LPS-induced IL-6 production in the absence of FBS. Linagliptin 21-32 interleukin 6 Homo sapiens 60-64 32705271-0 2020 Shikonin blocks human lung adenocarcinoma cell migration and invasion in the inflammatory microenvironment via the IL-6/STAT3 signaling pathway. shikonin 0-8 interleukin 6 Homo sapiens 115-119 34605100-12 2021 Following induced inflammation, both sexes exhibited an increase in IL-6 concentrations at 24H (BL v 24H: women 0.563 (0.50) v 1.141 (0.65) pg/mL; men 0.385 (0.17) v 1.113 (0.69) pg/mL p<0.05) that returned to near baseline concentrations by 48H (BL v 48H: p>0.05). 48H 252-255 interleukin 6 Homo sapiens 68-72 32705271-5 2020 In addition, we found that interleukin-6 (IL-6), which is expressed in THP-1-CM, promoted the EMT of lung adenocarcinoma cells, and shikonin markedly inhibited IL-6-induced EMT and cell motility. shikonin 132-140 interleukin 6 Homo sapiens 160-164 32705271-6 2020 Moreover, shikonin inhibited IL-6-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3), prevented phosphorylated STAT3 (p-STAT3) translocation into the nucleus, and suppressed p-STAT3 transactivation activity. shikonin 10-18 interleukin 6 Homo sapiens 29-33 33363521-7 2020 Butyrate administration significantly decreased LPS-induced rise in the clinical score of piglets and colonic histological scores and reduced the susceptibility to LPS-induced severe inflammatory response by decreasing proinflammatory (IL-1beta, IL-6, IL-8, and TNF-alpha) cytokines. Butyrates 0-8 interleukin 6 Homo sapiens 246-250 32705271-9 2020 Together, these results suggest that shikonin suppresses the migration and invasion of human lung adenocarcinoma cells in an inflammatory microenvironment involving the IL-6/STAT3 signaling pathway. shikonin 37-45 interleukin 6 Homo sapiens 169-173 34754315-10 2021 Molecular docking results showed that quercetin, luteolin, kaempferol, tanshinone IIa, wogonin, naringenin, nobiletin, dihydrotanshinlactone, beta-sitosterol, and salviolone have good affinity with core target proteins IL6, PTGS2, MAPK1, MAPK3, and CGRP1. gamma-sitosterol 142-157 interleukin 6 Homo sapiens 219-222 32418888-5 2020 We discovered that PCCs secrete CCL3 and stimulate IL-6, CCL2, ICAM-1 and VCAM-1 expression in MSCs and that the MSC-PCC crosstalk can be disrupted by the lipid-lowering drug simvastatin, which displays pleiotropic effects on cell metabolism and suppresses IL-6 and CCL2 production by MSCs and CCL3 secretion by PCCs. pyridinium chlorochromate 19-22 interleukin 6 Homo sapiens 51-55 33357720-5 2020 Additionally, TCDCA decreased tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6, IL-8 and IL-12 through nuclear factor kappa light chain enhancer of activated B cells (NF-kappaB) activity. Taurochenodeoxycholic Acid 14-19 interleukin 6 Homo sapiens 102-106 34737550-0 2021 Cinobufagin Suppresses the Characteristics of Osteosarcoma Cancer Cells by Inhibiting the IL-6-OPN-STAT3 Pathway (Retraction). cinobufagin 0-11 interleukin 6 Homo sapiens 90-94 34147605-5 2021 In our study, RAW264.7 macrophages were treated with different concentrations of BPF (0, 5, 10 and 20 muM) for 24 h. The results showed that the secretion of pro-inflammatory cytokines (IL-6, TNF-alpha and IL-1beta) and the production of lactate were increased in a dose-dependent manner. bisphenol F 81-84 interleukin 6 Homo sapiens 186-190 32865617-10 2020 In vitro, gammadelta T cells stimulated IL-6 production by PDAC-derived PSCs. pdac 59-63 interleukin 6 Homo sapiens 40-44 32898511-9 2020 LPS, Poly I:C and TNFalpha significantly induce the secretion of IL-6 and IL-8 at all tested time points. Poly I-C 5-13 interleukin 6 Homo sapiens 65-69 32557749-10 2020 Here, we found that the expression and secretion of TNF-alpha and IL-6 were enhanced by PA treatment. Palmitic Acid 88-90 interleukin 6 Homo sapiens 66-70 32646062-5 2020 The cytokine and oxylipin production by peripheral blood mononuclear cells (PBMCs) and neutrophils could be responsible for the plasma concentrations of TNFalpha and IL6, but not for the plasma concentration of oxylipins nor its post-exercise increase. Oxylipins 17-25 interleukin 6 Homo sapiens 166-169 34255319-7 2021 TNF-alpha, IL-6, and NF-kappaB expressions were also reduced noticeably after treatment with Vinpocetine. vinpocetine 93-104 interleukin 6 Homo sapiens 11-15 31925623-3 2020 The results showed that THP-1 cells, which were stimulated by LAMPs after pretreatment with H2S, had decreased production of interleukin-6 (IL-6) and interleukin-8 (IL-8) by inhibiting the mitogen-activated protein kinases (MAPKs)/nuclear factor-kappa B (NF-kappaB) signaling pathway and increased expression of HO-1 by activating the nuclear factor E2-related factor 2 (Nrf2) signaling pathway. hydrogen sulfite 92-95 interleukin 6 Homo sapiens 125-138 31925623-3 2020 The results showed that THP-1 cells, which were stimulated by LAMPs after pretreatment with H2S, had decreased production of interleukin-6 (IL-6) and interleukin-8 (IL-8) by inhibiting the mitogen-activated protein kinases (MAPKs)/nuclear factor-kappa B (NF-kappaB) signaling pathway and increased expression of HO-1 by activating the nuclear factor E2-related factor 2 (Nrf2) signaling pathway. hydrogen sulfite 92-95 interleukin 6 Homo sapiens 140-144 31925623-4 2020 Our results indicate that H2S may play an important role in attenuating inflammation induced by M. pneumoniae LAMPs due to its ability to decrease the production of IL-6 and IL-8 and increase the expression of the HO-1. hydrogen sulfite 26-29 interleukin 6 Homo sapiens 165-169 32221618-8 2020 Poly I:C increased IL-6 and MCP-1 protein production, and this effect was potentiated by LL-37. Poly I-C 0-8 interleukin 6 Homo sapiens 19-23 33135616-6 2021 RESULTS: B. animalis R101-8 inhibited LPS- and palmitic acid-induced protein expression of inflammatory cytokines IL-1beta, IL-6, TNF-alpha concomitant with decreases in chemerin, MCP-1, PEDF, and cellular triglycerides, and blocked NF-kB and AP-1 activation pathway through inhibition of p-IkappaBalpha, pc-Jun, and pc-Fos phosphorylation. Palmitic Acid 47-60 interleukin 6 Homo sapiens 124-128 33144864-12 2020 Namely, similar to BM-MSCs, SV-MSCs secreted increased amount of IL-6 and IL-8 after 12- or 24-hour treatment with LPS, PolyI:C, TNFalpha, or IL-1beta, compared to untreated controls. Poly I-C 120-127 interleukin 6 Homo sapiens 65-69 34288546-6 2021 Patients treated with furosemide plus HSS compared with controls treated with furosemide alone showed a comparable degree of reduction in the serum levels of interleukin (IL)-6, soluble suppression of tumorigenicity 2 (sST2), and N-terminal pro-brain natriuretic peptide (NT-proBNP) in the "between-group" analysis. Furosemide 78-88 interleukin 6 Homo sapiens 158-176 33069077-5 2020 Furthermore, BBH showed asignificant anti-inflammatory effect through regulating activities of SOD, MPOandexpressions of pro-inflammatory cytokines (TNF-alpha, IL-1beta and IL-6) in colontissue. alpha-hexachlorocyclohexane 13-16 interleukin 6 Homo sapiens 173-177 32064734-3 2020 The results showed that BCP and beta-TCP could support macrophages attachment, proliferation and spreading favorably, as well as promote gene expressions of inflammatory related cytokines (IL-1, IL-6, MCP-1 and TNF-alpha) and growth factors (TGF-beta, FGF, PDGF, VEGF, IGF and EGF). 3-benzyl-6-chloro-2-pyrone 24-27 interleukin 6 Homo sapiens 195-199 34820310-9 2021 Anthocyanin and ternatin were then predicted to be able to influence any inhibitory activity of TNF-alphaR, MMP-9, and IL-6; increase IL-10; and increase HBD2 binding affinity values negatively. Ternatin 16-24 interleukin 6 Homo sapiens 119-123 32696743-13 2020 Compared with the MCTP group, the cell proliferation ability increased, the production of IL-6 decreased, the mRNA levels of SMAD 2 and SMAD3, and the expression of TGF-beta1, SMAD2, SMAD3, p-SMAD2, p-SMAD3 proteins significantly decreased in the MCTP and SB431542-stimulated group. monocrotaline pyrrole 18-22 interleukin 6 Homo sapiens 90-94 33057114-8 2020 Although the overall effect of vitamin E supplementation on serum concentrations of interleukin-6 (IL-6) was not significant, a significant reduction in this cytokine was seen in studies that used alpha-tocopherol and those trials that included patients with disorders related to insulin resistance. Vitamin E 31-40 interleukin 6 Homo sapiens 84-97 33057114-8 2020 Although the overall effect of vitamin E supplementation on serum concentrations of interleukin-6 (IL-6) was not significant, a significant reduction in this cytokine was seen in studies that used alpha-tocopherol and those trials that included patients with disorders related to insulin resistance. Vitamin E 31-40 interleukin 6 Homo sapiens 99-103 34233590-9 2021 CONCLUSION: Curcumin has anti-inflammatory and anti-proliferative effects, and inhibits the development of HCC induced by TCE by reversing IL-6/STAT3 mediated EMT. Trichloroethylene 122-125 interleukin 6 Homo sapiens 139-143 32418114-9 2020 The levels of inflammatory cytokine IL-6 were significantly reduced from 22.2 (8.3-118.9) pg mL-1 at the beginning of the treatment to 5.2 (3.0-23.4) pg mL-1 (P<0.05) at the end of the treatment in the HCQ group but there is no change in the NHCQ group. nhcq 242-246 interleukin 6 Homo sapiens 36-40 32481596-6 2020 Cellular ceramide was elevated 2.67 +- 1.07-fold in RPE cells derived from diabetic donors compared to control donors, and these changes correlated with increased gene expression of IL-1beta, IL-6, and ASM. Ceramides 9-17 interleukin 6 Homo sapiens 192-196 34523302-7 2021 The specific inhibitory effect of DHEA on interleukin 6 (IL-6) could be of paramount importance in COVID-19. Dehydroepiandrosterone 34-38 interleukin 6 Homo sapiens 42-55 32547638-11 2020 Conclusions: Serum 25(OH)D3 levels were inversely associated with the summary inflammatory z-score and in particular with IL6 in the years following CRC diagnosis. Calcifediol 19-27 interleukin 6 Homo sapiens 122-125 33003647-11 2020 MiR-342-3p was negatively correlated with TIMP-1, IL-6, IL-8, TNF-alpha, HbA1c and CXCR2, whilst miR-342-5p was negatively correlated with TIMP-1, IL-6, IL-8 and HbA1c. mir-342-3p 0-10 interleukin 6 Homo sapiens 50-54 34523302-7 2021 The specific inhibitory effect of DHEA on interleukin 6 (IL-6) could be of paramount importance in COVID-19. Dehydroepiandrosterone 34-38 interleukin 6 Homo sapiens 57-61 32986368-9 2020 RESULTS: CpdA significantly inhibited cell cycle at G1 phase in CCA cell lines, and reduced IL-6 mRNA expression. CPDA 9-13 interleukin 6 Homo sapiens 92-96 34506568-10 2021 Correlation analysis showed that levels of LPS from severe patients were positively associated with IL-6 and IFN-gamma plasma concentrations and with IL-1beta transcripts, while IL-6 had a positive correlation with the cortisol/DHEA ratio. Dehydroepiandrosterone 228-232 interleukin 6 Homo sapiens 178-182 32554275-9 2020 Toxicological results revealed that indoor and personal exposure to OC as well as PAH compounds and their derivatives (e.g., Alkyl-PAHs, Oxy-PAHs) induced cell viability reduction and increase in levels of LDH, IL-6, and 8-isoprostane. alkyl-pahs 125-135 interleukin 6 Homo sapiens 211-215 32336102-7 2020 With almost equal surface content of PSBMA, the PSBMA-PDA-PP exhibited a more superior ability against macrophages adhesion and proliferation, and showed more significantly decreased releases of TNF-alpha and IL-6 (p < 0.05) than those of PSBMA@PDA-PP, fundamentally attributed to its more neutral surface potential and the protection for polyphenols of PDA from oxidation with PSBMA as the outer-layer. psbma 48-53 interleukin 6 Homo sapiens 209-213 32336102-7 2020 With almost equal surface content of PSBMA, the PSBMA-PDA-PP exhibited a more superior ability against macrophages adhesion and proliferation, and showed more significantly decreased releases of TNF-alpha and IL-6 (p < 0.05) than those of PSBMA@PDA-PP, fundamentally attributed to its more neutral surface potential and the protection for polyphenols of PDA from oxidation with PSBMA as the outer-layer. psbma 48-53 interleukin 6 Homo sapiens 209-213 34604020-3 2021 AIM: This study aimed to assess the relationship between serum cortisol, Interleukin-6 (IL-6) and homocysteine (Hcy) levels in AD. Homocysteine 98-110 interleukin 6 Homo sapiens 73-86 31705627-6 2020 RESULTS: SScDF-containing SAS showed increased stromal thickness, collagen deposition, and interleukin-6 secretion compared to NDF-containing SAS (P < 0.05). sscdf 9-14 interleukin 6 Homo sapiens 91-104 32807460-5 2020 Different studies showed the evidence that sphingomyelinase with Cer production induces expression of interleukin (IL)-6 and have vasoconstrictive proprieties. Ceramides 65-68 interleukin 6 Homo sapiens 102-120 32856796-8 2020 And the protein and mRNA expressions of TNF-alpha and IL-6 were increased by Phe, Flu, and their mixture, respectively. phenanthrene 77-80 interleukin 6 Homo sapiens 54-58 32824411-5 2020 We found that PA at 100 microM significantly increased the levels of IL6, while NLRP3 or the related Interleukin 1 beta (IL1beta) were not affected. Palmitic Acid 14-16 interleukin 6 Homo sapiens 69-72 32824411-7 2020 ELISA studies confirmed the stimulatory PA actions on IL6. Palmitic Acid 40-42 interleukin 6 Homo sapiens 54-57 32296091-6 2020 There were significant correlations between baseline and one-year dialysis effluent IL-6 and COX-2 levels with the corresponding dialysate-to-plasma creatinine level at 4 hours (D/P4) and mass transfer area coefficient of creatinine (MTAC). Tetradecyltrimethylammonium chloride 234-238 interleukin 6 Homo sapiens 84-88 34604020-3 2021 AIM: This study aimed to assess the relationship between serum cortisol, Interleukin-6 (IL-6) and homocysteine (Hcy) levels in AD. Homocysteine 98-110 interleukin 6 Homo sapiens 88-92 32648603-6 2020 AXT also inhibited the induction of COX-2 and IL-6 in human chondrocytes and synovial fibroblasts by western blots. astaxanthine 0-3 interleukin 6 Homo sapiens 46-50 34604020-3 2021 AIM: This study aimed to assess the relationship between serum cortisol, Interleukin-6 (IL-6) and homocysteine (Hcy) levels in AD. Homocysteine 112-115 interleukin 6 Homo sapiens 73-86 32415642-7 2020 The IL-6 concentration in D5-NTQ or D6-TQ SBCM was higher than that in D5-TQ or D6-NTQ SBCM (P < 0.05), respectively. d6-tq 36-41 interleukin 6 Homo sapiens 4-8 34604020-3 2021 AIM: This study aimed to assess the relationship between serum cortisol, Interleukin-6 (IL-6) and homocysteine (Hcy) levels in AD. Homocysteine 112-115 interleukin 6 Homo sapiens 88-92 32415642-7 2020 The IL-6 concentration in D5-NTQ or D6-TQ SBCM was higher than that in D5-TQ or D6-NTQ SBCM (P < 0.05), respectively. d5- 26-29 interleukin 6 Homo sapiens 4-8 32061902-8 2020 Anthocyanin supplementation also down-regulated the expression of NF-kappaB dependent genes including TNF-alpha (-28% and -15%), IL-6 (-16.1% and-13.6%), IL-1A (-21.5% and-12.9%), PCAM-1 (-15% and-17.5%), and COX-2(-26% and-27%) in both MetS and Control group respectively (P-value < 0.05). Anthocyanins 0-11 interleukin 6 Homo sapiens 129-133 34425652-8 2021 Addition of Linagliptin significantly reduced IL-6 levels in the lysates of cells, treated with Abeta1-42. Linagliptin 12-23 interleukin 6 Homo sapiens 46-50 31887846-9 2020 Results: The expression of IL6 and IL6R increased during adipogenesis differentiation in MSCs, which were positively correlated with Oil Red O quantification result. oil red O 133-142 interleukin 6 Homo sapiens 27-30 32500755-9 2021 RESULTS: Naringin or SB203580 pretreatment significantly suppressed the secretion of TNF-alpha and IL-6 induced by titanium particles in fibroblasts, while inhibition of ERK or JNK pathways showed no effect on production of TNF-alpha and IL-6. SB 203580 21-29 interleukin 6 Homo sapiens 99-103 32500755-9 2021 RESULTS: Naringin or SB203580 pretreatment significantly suppressed the secretion of TNF-alpha and IL-6 induced by titanium particles in fibroblasts, while inhibition of ERK or JNK pathways showed no effect on production of TNF-alpha and IL-6. SB 203580 21-29 interleukin 6 Homo sapiens 238-242 34425652-10 2021 Conclusion: The current findings reveal that linagliptin alleviates Abeta1-42-induced inflammation in SH-SY5Y cells, probably through the suppression of IL-6 release, and some of its benefits are mediated through the activation of the Wnt1 signaling pathway. Linagliptin 45-56 interleukin 6 Homo sapiens 153-157 32541643-12 2020 CONCLUSIONS Valsartan inhibited the increase in hs-CRP and IL-6 levels, improved clinical efficacies, increased ABI, and decreased the restenosis rate after the interventional therapy in patients with arteriosclerosis obliterans of the lower extremities. Valsartan 12-21 interleukin 6 Homo sapiens 59-63 31935365-6 2020 Exposure to the LPS increased the production of IL-6 in both HAEC and D-HAEC cell lines (P-value < 0.0001), whereas AC treatment reduced LPS-induced IL-6 production in both cell lines with a more robust impact on D-HAEC (P-value < 0.0001). Anthocyanins 119-121 interleukin 6 Homo sapiens 152-156 34452519-12 2021 Astodrimer sodium 1% significantly reduced the pro-inflammatory cytokines IL-6, IL-1alpha, IL-1beta, TNFalpha and TGFbeta and the chemokine MCP-1 in the serum, lung and trachea vs. PBS. astodrimer sodium 0-17 interleukin 6 Homo sapiens 74-78 31802382-4 2020 Viability testing showed that ellipticine was not significantly toxic to Raw264.7 cells and actually conveyed protective effects to LPS-stimulated Raw264.7 cells and human peripheral blood monocytes by decreasing the secretion of inflammatory factors (TNF-alpha and IL-6). ellipticine 30-41 interleukin 6 Homo sapiens 266-270 32582751-2 2020 Among the phytonutrients, epidemiological and experimental studies show that dietary organosulfur compounds (OSC) play a significant role in preventing various human pathological progressions, including chronic inflammation, by decreasing inflammatory mediators such as nitric oxide (NO), prostaglandin (PG)E2, interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha, and IL-17, which are all typical hallmarks of inflammation. organosulfur compounds 85-107 interleukin 6 Homo sapiens 335-339 32220649-8 2020 Higher level of IL-6 was associated with better response to escitalopram treatment in PD patients. Citalopram 60-72 interleukin 6 Homo sapiens 16-20 32220649-10 2020 CONCLUSION: The present findings suggest that patients with PD may have higher levels of IL-6 than GAD, and higher baseline levels of IL-6 may be a better response to escitalopram in the treatment of PD. Citalopram 167-179 interleukin 6 Homo sapiens 134-138 32211116-12 2020 In addition, transfection of HRMCs and HK-2 cells with miR-203 mimics could suppress TRAF6-induced IL-beta, IL-6, or TNF-alpha expression compared to cells treated with the mimics control group. hrmcs 29-34 interleukin 6 Homo sapiens 108-112 34540066-0 2021 Total serum IL-6 and TNF-C levels in children with bronchopneumonia following treatment with methylprednisolone in combination with azithromycin. Methylprednisolone 93-111 interleukin 6 Homo sapiens 12-16 32067619-7 2020 We performed RT-qPCR to demonstrate the expression changes of the genes in IL-6/JAK/STAT pathway in ARH-77 and NCI-BL 2171 cells treated with ruxolitinib. ruxolitinib 142-153 interleukin 6 Homo sapiens 75-79 32067619-10 2020 Treatment with ruxolitinib decreased the expressions of IL-6, IL-18, JAK2, TYK2 and, AKT genes which play significant roles in MM pathogenesis. ruxolitinib 15-26 interleukin 6 Homo sapiens 56-60 32069432-6 2020 MCP-1 and GM-CSF levels, as well as gene expressions of IL-6 and IL-8 in HTR8/SVneo cells were greatly increased by TNF-alpha (5, 10 and 20 ng/mL), but reversed by sevoflurane and SB203580. SB 203580 180-188 interleukin 6 Homo sapiens 56-60 34540066-1 2021 OBJECTIVE: To analyze the expression levels of total serum interleukin (IL)-6 and tumor necrosis factor (TNF)-C in children with bronchopneumonia treated by methylprednisolone in combination with azithromycin. Methylprednisolone 157-175 interleukin 6 Homo sapiens 59-77 32483313-0 2020 Anesthetic propofol epigenetically regulates breast cancer trastuzumab resistance through IL-6/miR-149-5p axis. Propofol 11-19 interleukin 6 Homo sapiens 90-94 32483313-5 2020 Increased cytokines IL-6 as well as IL-8 were released by resistant cells, along with increased mammospheres and induction of EMT, all of which was inhibited by propofol. Propofol 161-169 interleukin 6 Homo sapiens 20-24 32067619-11 2020 CONCLUSION: All in all, ruxolitinib is a promising agent for the regulation of IL-6/JAK/STAT pathway and interfering with autophagy mechanism in MM. ruxolitinib 24-35 interleukin 6 Homo sapiens 79-83 34445390-6 2021 LPS-induced activation of NFAT-regulated cytokines (IL-6 and IL-8) is inhibited by treatment of cells with VIVIT. NFAT Inhibitor 107-112 interleukin 6 Homo sapiens 52-56 31705791-8 2020 The most striking result was the significant correlation observed between seminal IL-6 and spermatozoid concentration, progressive motility, and sperm vitality. spermatozoid 91-103 interleukin 6 Homo sapiens 82-86 32483313-6 2020 IL-6 targeting tumor suppressor miR-149-5p was found to be the novel miRNA that was up-regulated by propofol, resulting in the observed effects on cell viability, IL-6 production, mammospheres generation as well as EMT induction. Propofol 100-108 interleukin 6 Homo sapiens 0-4 32463805-9 2020 Avicularin significantly upregulated the expression levels IL-1ss, IL-6, and TNF-alpha in the bradykinin treated group in a dose-dependent manner. avicularin 0-10 interleukin 6 Homo sapiens 67-71 31669599-5 2020 Subgroup analyses showed that administration of higher doses of anthocyanins (>300 mg/day) significantly decreased levels of CRP, IL-6, TNF-alpha, and VCAM-1. Anthocyanins 64-76 interleukin 6 Homo sapiens 130-134 34424286-6 2021 Results: In the MDR-PA group, significantly (P < 0.05) increased expression of IL-6, IL-8, IL-10, IL-1beta, and TNF-alpha was observed in comparison with the S-PA group. s-pa 158-162 interleukin 6 Homo sapiens 79-83 31654094-5 2020 Ruxolitinib was additionally found to block the activation of the IL6/JAK/signal transducer and activator of transcription (STAT) pathway triggered by LPS and whose inhibition by the neutralizing anti-IL6 receptor antibody tocilizumab prevented CRP induction. ruxolitinib 0-11 interleukin 6 Homo sapiens 66-69 31654094-5 2020 Ruxolitinib was additionally found to block the activation of the IL6/JAK/signal transducer and activator of transcription (STAT) pathway triggered by LPS and whose inhibition by the neutralizing anti-IL6 receptor antibody tocilizumab prevented CRP induction. ruxolitinib 0-11 interleukin 6 Homo sapiens 201-204 31654094-6 2020 CONCLUSION: Ruxolitinib can potently repress induction of CRP in inflammatory human hepatocytes, most likely through targeting the IL6/JAK/STAT signalling cascade. ruxolitinib 12-23 interleukin 6 Homo sapiens 131-134 32448273-9 2020 In vivo studies suggested the topical application of TRA and BT dual-loaded liposomal gel had the best ability to reduce the thickness of epidermal and the level of cytokines (TNF-alpha and IL-6), largely alleviating the symptoms of psoriasis. Betamethasone 61-63 interleukin 6 Homo sapiens 190-194 32040591-9 2020 PMB suppressed IL-1beta (P = 0.035) and IL-6 (P = 0.0487) production in the 3 h PPB of the PS after 24 h incubation at 37 C compared to the vehicle control, suggesting the presence of LPS. Polymyxin B 0-3 interleukin 6 Homo sapiens 40-44 34300281-0 2021 Decreased Production of TNF-alpha and IL-6 Inflammatory Cytokines in Non-Pregnant Idiopathic RPL Women Immunomodulatory Effect of Sildenafil Citrate on the Cellular Response of Idiopathic RPL Women. Sildenafil Citrate 130-148 interleukin 6 Homo sapiens 38-42 32057949-10 2020 Furthermore, silencing of AL049437 alleviated MPP+-induced neuroinflammation and oxidative stress, as indicated by the reduction in tumor necrosis factor-alpha and interleukin-6 levels and reactive oxygen species production. 1-(4-methoxyphenyl)pyridinium 46-49 interleukin 6 Homo sapiens 164-177 32179241-7 2020 A slight reduction in serum IL-6, TNF-alpha, and urine 8-iso-PGF2alpha from the baseline was observed at 12 weeks in the group receiving 40 mg/day anthocyanins. Anthocyanins 147-159 interleukin 6 Homo sapiens 28-32 32179241-8 2020 Anthocyanins (80 mg/day) significantly reduced serum IL-6 (-20%), TNF-alpha (-11%) and urine 8-iso-PGF2alpha (-27%) versus baseline (P < 0.05). Anthocyanins 0-12 interleukin 6 Homo sapiens 53-57 32922496-11 2020 Sclareol was also capable of suppressing the function of IL-6 in modulating the expression of apoptosis-associated genes. sclareol 0-8 interleukin 6 Homo sapiens 57-61 31816985-5 2019 Also, TMS-TMF-4f suppressed both constitutive and IL-6-inducible levels of phosphorylated STAT3 (p-STAT3) and associated proteins such as Mcl-1, cyclin D1, survivin, and c-Myc in both cervical cancer cells. thiomarinol F 6-16 interleukin 6 Homo sapiens 50-54 32179241-9 2020 Moreover, 320 mg/day anthocyanin supplementation reduced serum IL-6 (-40%), TNF-alpha (-21%), MDA (-20%) and urine 8-iso-PGF2alpha (-37%) and 8-OHdG (-36%) than 80 mg/day and 40 mg/day anthocyanins, P value < 0.05. Anthocyanins 21-32 interleukin 6 Homo sapiens 63-67 34222847-10 2021 A decrease from baseline was higher in the NTZ group for d-Dimer (p = 0.001), US-RCP (p < 0.002), TNF (p < 0.038), IL-6 (p < 0.001), IL-8 (p = 0.014), HLA DR. on CD4+ T lymphocytes (p < 0.05), CD38 in CD4+ and CD8+ T (both p < 0.05), and CD38 and HLA-DR. on CD4+ (p < 0.01). nitazoxanide 43-46 interleukin 6 Homo sapiens 115-119 32326355-7 2020 Both trichothecenes also enhanced transcript levels of the known NF-kappaB-dependent pro-inflammatory cytokines IL-8, IL-6, TNF-alpha and IL-1beta. Trichothecenes 5-19 interleukin 6 Homo sapiens 118-122 31930074-9 2019 Antifungal treatment could decrease the level of interleukin-1beta, interleukin-6, tumor necrosis factor-alpha and interferon-gamma in CTG than in CNTG (P<0.05, respectively). ctg 135-138 interleukin 6 Homo sapiens 68-110 34237013-8 2021 Serum inflammatory markers PCT, adiponectin, C-reactive protein-1, osteoprotegerin (OPG), osteopontin (OPN), and interleukin 6 (IL-6) were analyzed in patients with DFO and controls. dfo 165-168 interleukin 6 Homo sapiens 113-126 31377584-3 2019 It is unknown whether CTF-induced IL6 regulates the expression of MMPs, enzymes needed for tissue remodeling. CHEMBL408967 22-25 interleukin 6 Homo sapiens 34-37 31377584-5 2019 Using a neutralizing anti-IL6 antibody and addition of recombinant human IL6 at concentrations of 0.1, 1, 10 ng.mL-1 were performed to clarify whether CTF-upregulated IL6 increased MMP expression. CHEMBL408967 151-154 interleukin 6 Homo sapiens 26-29 31377584-10 2019 CONCLUSION: Our findings suggest a role of CTF in the modulation of expression of IL6 and MMP3 and thus in the regulation of homeostasis and remodeling of the periodontal ligament. CHEMBL408967 43-46 interleukin 6 Homo sapiens 82-85 32295051-10 2020 DMF alleviated inflammatory responses by reducing the tumor necrosis factor-alpha and interleukin-6 serum and mRNA levels. 5,7-dimethoxyflavone 0-3 interleukin 6 Homo sapiens 86-99 34237013-8 2021 Serum inflammatory markers PCT, adiponectin, C-reactive protein-1, osteoprotegerin (OPG), osteopontin (OPN), and interleukin 6 (IL-6) were analyzed in patients with DFO and controls. dfo 165-168 interleukin 6 Homo sapiens 128-132 32290188-7 2020 In vitro validation experiments revealed that co-incubation with lactate and pyruvate enhances IL-10 production and attenuates the release of pro-inflammatory IL-1beta and IL-6 by LPS-stimulated leukocytes. Pyruvic Acid 77-85 interleukin 6 Homo sapiens 172-176 34199278-10 2021 Taken together, our results suggest that MAPKs play a contributory role in IL-1beta and IL-6 mRNA expression when induced by both DON and PCV2. deoxynivalenol 130-133 interleukin 6 Homo sapiens 88-92 34163151-8 2021 Results: Three phytocompounds including isoorientin, lupeol, and andrographolide have shown strong interactions with the targeted protein IL-6 with least binding energies (-7.1 to -7.7 kcal/mol). andrographolide 65-80 interleukin 6 Homo sapiens 138-142 31954196-6 2020 Furthermore, the levels of IL-6 and IL-8 showed a stronger correlation with corneal fluorescein staining (CFS) (P<0.05), and the levels of IL-6 and ICAM-1 were most consistent with fluorescein tear film break-up time (TBUT) (P<0.05). Fluorescein 84-95 interleukin 6 Homo sapiens 27-31 31195139-0 2019 Clinical Impacts of Using Serum IL-6 Level as an Indicator of Cytokine Release Syndrome after HLA-Haploidentical Transplantation with Post-Transplantation Cyclophosphamide. Cyclophosphamide 155-171 interleukin 6 Homo sapiens 32-36 34122411-8 2021 Curcumin-a natural polyphenol compound with known antifibrotic effects in various tissues-alleviated IL-6-induced EndMT and promoted autophagy in the allografted organ and in HUVECs. curcumin-a 0-10 interleukin 6 Homo sapiens 101-105 31545276-10 2019 After GSZD treatment, the adhesive and invasive abilities of MH7A cells were reduced, and secretions of MMPs, IL-6 and IL-8 were also reduced. gszd 6-10 interleukin 6 Homo sapiens 110-114 31954196-6 2020 Furthermore, the levels of IL-6 and IL-8 showed a stronger correlation with corneal fluorescein staining (CFS) (P<0.05), and the levels of IL-6 and ICAM-1 were most consistent with fluorescein tear film break-up time (TBUT) (P<0.05). Fluorescein 184-195 interleukin 6 Homo sapiens 142-146 30706385-7 2019 Overexpression of IL-6 can reverse si-HDAC2-induced suppression of cell migration. Silicon 10-12 interleukin 6 Homo sapiens 18-22 34150059-8 2021 The serum levels of interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor (TNF-alpha), malondialdehyde (MDA) and advanced oxidation protein products (AOPP) in the CG were lower than those in the MG after treatment, while the level of glutathione peroxidase (GSH-Px) was higher (P < 0.05). cg 179-181 interleukin 6 Homo sapiens 20-33 31632401-0 2019 Interleukin-6 as Biomarker for Acute GvHD and Survival After Allogeneic Transplant With Post-transplant Cyclophosphamide. Cyclophosphamide 104-120 interleukin 6 Homo sapiens 0-13 32244640-10 2020 However, SDSX16-P10 was found to cause lower levels of cytokine expression than SDSX16-P75 using real-time PCR and flow cytometry, such as IL1beta, IL6, IFN-beta, TNF-alpha, indicating that SDSX16-P10 might inhibit the expression of cytokines. sdsx16 9-15 interleukin 6 Homo sapiens 148-151 32196489-9 2020 Blockade of IL-6 signaling with IL-6 receptor antibody and JAK inhibitor (Ruxolitinib) inhibited M2 polarization of THP-1-derived macrophages and proliferation of the macrophages. ruxolitinib 74-85 interleukin 6 Homo sapiens 12-16 34150059-8 2021 The serum levels of interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor (TNF-alpha), malondialdehyde (MDA) and advanced oxidation protein products (AOPP) in the CG were lower than those in the MG after treatment, while the level of glutathione peroxidase (GSH-Px) was higher (P < 0.05). cg 179-181 interleukin 6 Homo sapiens 35-39 32201152-5 2021 Ruxolitinib decreases the activity of type I T-helper cells, leading to decreased release of cytokines including tumor necrosis factor-alpha, interleukin-1 (IL-1), IL-6, interferon-gamma, and production of IL-12, which can be a risk factor for opportunistic infections. ruxolitinib 0-11 interleukin 6 Homo sapiens 164-168 34928078-5 2021 Molecular-level investigations reveal that MXene exhibits a strong chemisorption mechanism for immobilizing cytokine interleukin-6 molecules, which is different from activated carbon absorbents. mxene 43-48 interleukin 6 Homo sapiens 117-130 31919136-11 2020 CONCLUSIONS: The inflammatory cytokine IL6 may be predictive of therapeutic benefit from bevacizumab when combined with carboplatin and paclitaxel. Carboplatin 120-131 interleukin 6 Homo sapiens 39-42 31701079-0 2019 Calcifediol Decreases Interleukin-6 Secretion by Cultured Human Trophoblasts From GDM Pregnancies. Calcifediol 0-11 interleukin 6 Homo sapiens 22-35 31701079-2 2019 This study aimed to determine whether placental protein expressions of CYP27B1, vitamin D receptor (VDR), and CYP24A1 are impaired in GDM and to investigate the effect of a 25OHD treatment on IL-6 secretion by GDM trophoblasts compared with normoglycemic (NG) trophoblasts. 1,25,26-trihydroxyvitamin D3 173-178 interleukin 6 Homo sapiens 192-196 31701079-7 2019 In cultured trophoblasts (two groups; n = 5 NG and n = 5 GDM-d), exposure to increasing 25OHD concentrations significantly decreased IL-6 secretion in the GDM-d group only (P = 0.006). 1,25,26-trihydroxyvitamin D3 88-93 interleukin 6 Homo sapiens 133-137 31701079-8 2019 After treatment with 25OHD (2000 nM), IL-6 secretion was lower in the GDM-d group compared with the NG group (P = 0.03). 1,25,26-trihydroxyvitamin D3 21-26 interleukin 6 Homo sapiens 38-42 34348637-6 2021 Additionally, triterpene acid mixture (ursolic acid, oleanolic acid, and betulinic acid), also isolated from rosehip, has been reported to reduce the production of interleukin-6 and Tumor necrosis factor-alpha. triterpene acid 14-29 interleukin 6 Homo sapiens 164-177 31814493-7 2020 In vitro anti-inflammatory experiments showed that FF inhibited the secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and synthesis of NO in a dose-dependent manner, while FF-NC showed a stronger anti-inflammatory effect than FF under the same dose. florfenicol 51-53 interleukin 6 Homo sapiens 122-135 31814493-7 2020 In vitro anti-inflammatory experiments showed that FF inhibited the secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and synthesis of NO in a dose-dependent manner, while FF-NC showed a stronger anti-inflammatory effect than FF under the same dose. florfenicol 51-53 interleukin 6 Homo sapiens 137-141 31346790-6 2019 Moreover, urinary arsenic exposure was also associated with higher levels of fasting (P < 0.001) and random blood glucose (P < 0.001), HbA1c (P < 0.001), AST, ALT, MDA, IL-6, CRP, blood urea nitrogen, and creatinine in arsenic-exposed diabetics as compared with that of unexposed diabetics. Arsenic 18-25 interleukin 6 Homo sapiens 178-182 35623502-6 2022 Conversely, SC144, an inhibitor of the gp130 component of the IL-6 receptor, enhanced IL-6 production induced by LPS and NiNPs. SC 144 12-17 interleukin 6 Homo sapiens 86-90 31115691-8 2020 RESULTS: Endomethasone N decreased secretion of IL-6 and TNF-alpha from hPDL cells. corticosteroid methanetriol mixture 9-22 interleukin 6 Homo sapiens 48-52 35623502-6 2022 Conversely, SC144, an inhibitor of the gp130 component of the IL-6 receptor, enhanced IL-6 production induced by LPS and NiNPs. ninps 121-126 interleukin 6 Homo sapiens 86-90 31077718-12 2019 Similarly, 5-AzadC-treated OA synoviocytes showed decreased expression of IRAK-1, IL1Beta and IL-6, which was reversed following 5-AzadC-/miR-146a inhibitor treatment. Decitabine 11-18 interleukin 6 Homo sapiens 94-98 35576915-11 2022 CONCLUSION: Our results show that active tVNS led to an immediate increase in the serum concentrations of certain pro-inflammatory cytokines such as IL-1beta, IL-6, and/or IL-8 in two independent cohorts of healthy study participants. tvns 41-45 interleukin 6 Homo sapiens 159-163 31077718-12 2019 Similarly, 5-AzadC-treated OA synoviocytes showed decreased expression of IRAK-1, IL1Beta and IL-6, which was reversed following 5-AzadC-/miR-146a inhibitor treatment. Decitabine 129-136 interleukin 6 Homo sapiens 94-98 29941233-11 2019 CONCLUSIONS: In very premature infants, early administration of fish oil containing LE significantly decreased IL-1beta and IL-6 levels in serum and BALF and was associated with shorter duration of ventilator support and less bronchopulmonary dysplasia (BPD). Fish Oils 64-72 interleukin 6 Homo sapiens 124-128 32080341-10 2020 Pharmacological inhibition of PAP1 with propranolol suppressed UVB-induced production of IL-6 and IL-8 in NHEKs and reconstituted human skin models. Propranolol 40-51 interleukin 6 Homo sapiens 89-93 35562182-7 2022 Multiple cycles of intravenous c-JO4 plus Doxil (four cycles, 4 weeks apart, simulating the treatment regimen in the clinical trial) elicited antibodies against c-JO4 that increased with each cycle and were accompanied by elevation of pro-inflammatory cytokines IL-6 and TNFalpha. c-jo4 31-36 interleukin 6 Homo sapiens 262-266 31610702-9 2020 Inflammatory effects of L-NAME were investigated by measuring tumor necrosis factor-alpha and interleukin-6 (IL-6) levels. NG-Nitroarginine Methyl Ester 24-30 interleukin 6 Homo sapiens 94-107 31979221-6 2020 An up to 60-fold higher formation of steroid hormones and their sulfated or glucuronidated metabolites was observed in carboplatin-sensitive cells, which was reversible by treatment with interleukin-6 (IL-6). Carboplatin 119-130 interleukin 6 Homo sapiens 187-200 31979221-6 2020 An up to 60-fold higher formation of steroid hormones and their sulfated or glucuronidated metabolites was observed in carboplatin-sensitive cells, which was reversible by treatment with interleukin-6 (IL-6). Carboplatin 119-130 interleukin 6 Homo sapiens 202-206 31095595-8 2019 Our analyses demonstrated that IL-1b, IL-2, IL-4 and IL-6 were significantly stimulated as a function of urinary arsenic levels in models adjusted for age, body mass index (BMI), smoking status and PAH-DNA adducts. Arsenic 113-120 interleukin 6 Homo sapiens 53-57 31979221-7 2020 Conversely, treatment of carboplatin-resistant cells expressing high levels of endogenous IL-6 with the monoclonal anti-IL-6R antibody tocilizumab changed their status to "platinum-sensitive", exhibiting a decreased IC50 value for carboplatin, decreased growth, and significantly higher estrogen metabolism. Carboplatin 25-36 interleukin 6 Homo sapiens 90-94 31979221-7 2020 Conversely, treatment of carboplatin-resistant cells expressing high levels of endogenous IL-6 with the monoclonal anti-IL-6R antibody tocilizumab changed their status to "platinum-sensitive", exhibiting a decreased IC50 value for carboplatin, decreased growth, and significantly higher estrogen metabolism. Carboplatin 231-242 interleukin 6 Homo sapiens 90-94 30851246-3 2019 When tested in vitro on human dendritic cells (DCs), CHF6001 decreased the release of pro-inflammatory cytokines (TNF-alpha and IL-6), chemokines (CXCL8, CCL3, CXCL10 and CCL19) and of Th1- and Th17-polarizing cytokines (IL-12, IL-23 and IL-1beta). 3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3-(cyclopropylmethoxy)-4-(methylsulfonamido)benzoyloxy)ethyl)pyridine 1-oxide 53-60 interleukin 6 Homo sapiens 128-132 35571122-9 2022 Both mycophenolic acid and rapamycin inhibited inflammatory and fibrotic processes induced by TGF-beta1 or IL-6 by downregulating mTOR and ERK phosphorylation. Mycophenolic Acid 5-22 interleukin 6 Homo sapiens 107-111 31008484-8 2019 The stimulatory effects of 17-phenyl-trinor-PGE2 on IL-6 and TNFalpha were remained whereas the inhibitory effects of 17-phenyl-trinor-PGE2 on IL-1beta secretion was blocked in the cells with EP1 knockdown. 17-phenyltrinorprostaglandin E2 27-48 interleukin 6 Homo sapiens 52-56 31008484-11 2019 PI3K inhibitor LY294002 and P38 inhibitor SB202190 blocked 17-phenyl-trinor-PGE2-induced IL-1beta and IL-6 output, respectively. 17-phenyltrinorprostaglandin E2 59-80 interleukin 6 Homo sapiens 102-106 31414991-5 2020 RESULTS: No association between increased levels of the inflammatory markers and change on the CDR-SB or MMSE score was found, but there was a significant difference in baseline IL-6 and interleukin-1 receptor antagonist levels between aMCI and AD dementia groups. amci 236-240 interleukin 6 Homo sapiens 178-182 35292250-2 2022 This study aimed to explore wound healing capacity of sea cucumber-derived tetrapeptides with amino acid sequence of Val-Thr-Pro-Tyr (VTPY) and Val-Leu-Leu-Tyr (VLLY) by human skin fibroblast (HSF) and human umbilical vein endothelial cells (HUVEC) in vitro. val-leu-leu-tyr 144-159 interleukin 6 Homo sapiens 193-196 32475915-7 2020 Moreover, Ziyuglycoside II reversed RV-induced downregulation of anti-inflammatory cytokine interleukin (IL)-10 and upregulation of pro-inflammatory factors, such as interferon-gamma (IFN-gamma), IL-1beta, IL-6, and tumor necrosis factor (TNF-alpha). ziyuglycoside II 10-26 interleukin 6 Homo sapiens 206-210 30623574-7 2019 Both Erlotinib (Tarceva) and Osimertinib (AZD-9291) reduced the levels of HDM-stimulated IL-6 and IL-8 levels in BEAS-2B cells. Erlotinib Hydrochloride 5-14 interleukin 6 Homo sapiens 89-93 30623574-7 2019 Both Erlotinib (Tarceva) and Osimertinib (AZD-9291) reduced the levels of HDM-stimulated IL-6 and IL-8 levels in BEAS-2B cells. Erlotinib Hydrochloride 16-23 interleukin 6 Homo sapiens 89-93 30623574-7 2019 Both Erlotinib (Tarceva) and Osimertinib (AZD-9291) reduced the levels of HDM-stimulated IL-6 and IL-8 levels in BEAS-2B cells. osimertinib 29-40 interleukin 6 Homo sapiens 89-93 30623574-10 2019 Our findings highlight EGFR-TKIs, Tarceva, and AZD-9291, attenuate HDM-induced inflammatory IL-6 and IL-8 cytokines via EGFR signaling axis pathway, but not AMPK signaling pathway. Erlotinib Hydrochloride 34-41 interleukin 6 Homo sapiens 92-96 35292250-3 2022 The results showed that VTPY and VLLY possessed excellent capacity to induce the proliferation and migration of HSF cells and HUVEC cells. vtpy 24-28 interleukin 6 Homo sapiens 112-115 32400338-11 2020 The PA-induced phosphorylation of the inflammatory pathway mediators IKK and NF-kappaB, as well as the elevated expression and secretion of proinflammatory cytokines (IL-6, TNF-alpha), were reduced in cells pre-exposed to HEL. Palmitic Acid 4-6 interleukin 6 Homo sapiens 167-171 35292250-8 2022 Overall, peptides of VTPY and VLLY possessed outstanding capacity to induce the proliferation and migration of HSF cells and HUVEC cells in vitro and the mechanism was mainly related to improving mitochondrial respiratory capacity to produce more ATP for biological energy, blocking the binding of MKP to ERK2 and PHLPP to AKT and thus upregulating the ERK/AKT pathway. vtpy 21-25 interleukin 6 Homo sapiens 111-114 35479322-16 2022 Conclusion: A single sub-anesthetic dose (0.3 mg kg-1) of ketamine can significantly improve the postoperative anxiety and depression of colorectal cancer patients and reduce the levels of IL-6, IL-8, and TNF-alpha. Ketamine 58-66 interleukin 6 Homo sapiens 189-193 31452174-5 2020 Ruxolitinib treatment resulted in the production of IL-6 and active formation of IL-6 receptor complex for the subsequent activation of the IL-6R/JAK2/STAT3 axis. ruxolitinib 0-11 interleukin 6 Homo sapiens 52-56 31452174-5 2020 Ruxolitinib treatment resulted in the production of IL-6 and active formation of IL-6 receptor complex for the subsequent activation of the IL-6R/JAK2/STAT3 axis. ruxolitinib 0-11 interleukin 6 Homo sapiens 81-85 31452174-9 2020 CONCLUSION: The specific JAK2 inhibitor ruxolitinib plays an important role in glioblastoma angiogenesis biology via inhibiting IL-6 receptor-dependent JAK/STAT signaling. ruxolitinib 40-51 interleukin 6 Homo sapiens 128-132 30783936-8 2019 The changing levels of As, Zn and Se seems to affect the severity of inflammatory reactions based on IL-6, IL-10 and TNF-alpha levels (r = 0.755, r = 0.679 and r = 0.617, respectively, for all p < 0.01). Arsenic 23-25 interleukin 6 Homo sapiens 101-105 30984167-12 2019 Results: Tofacitinib and baricitinib decreased the IL-6 release of RASF stimulated with oncostatin M. baricitinib 25-36 interleukin 6 Homo sapiens 51-55 30984167-14 2019 In contrast, only peficitinib and filgotinib decreased the IL-6 release of RASF activated with IL-1beta. GLPG0634 34-44 interleukin 6 Homo sapiens 59-63 34999320-0 2022 Microfluidic electrochemical magnetoimmunosensor for ultrasensitive detection of interleukin-6 based on hybrid of AuNPs and graphene. Graphite 124-132 interleukin 6 Homo sapiens 81-94 31007601-8 2019 During M1 polarization, propofol suppressed the production of IL-6 and IL-1beta but did not affect TNF-alpha production. Propofol 24-32 interleukin 6 Homo sapiens 62-66 31007601-10 2019 Propofol was similar to the GABAA agonist muscimol in inducing nuclear translocation of nuclear factor-E2-related factor 2 (Nrf2) and inhibiting IL-6 and IL-1beta, but not TNF-alpha, production. Propofol 0-8 interleukin 6 Homo sapiens 145-149 31007601-11 2019 Knockdown of Nrf2 using siRNA significantly reduced the effect of propofol on IL-6 and IL-1beta production. Propofol 66-74 interleukin 6 Homo sapiens 78-82 31849975-5 2019 Our results showed JDBM, extract, and MgCl2 could decrease LPS-induced tumor necrosis factor (TNF) and interleukin (IL)-6 expression. Magnesium Chloride 38-43 interleukin 6 Homo sapiens 103-121 31849975-9 2019 Interestingly, the expression of LPS-induced TNF and IL-6 could be recovered by knocking down TRPM7 of macrophages, in the presence of extract or MgCl2. Magnesium Chloride 146-151 interleukin 6 Homo sapiens 53-57 31123968-6 2019 Accordingly, LPS-induced increases in IL-1beta and IL-6 mRNA and TNF-alpha release were significantly and synergistically diminished by cilostazol and celecoxib cotreatment. Cilostazol 136-146 interleukin 6 Homo sapiens 51-55 31007601-12 2019 These results suggest that propofol prevents inflammatory responses during polarization of human M1 macrophages by suppressing the expression of IL-6 and IL-1beta through the GABAA receptor and the Nrf2-mediated signal transduction pathway. Propofol 27-35 interleukin 6 Homo sapiens 145-149 35408584-8 2022 Measuring IL-6, TNFalpha, and IL-1beta pro-inflammatory cytokines released from LPS-stimulated THP-1 cells, calceolarioside A in a concentration-dependent manner reduced the release of these cytokines from THP-1 cells. calceolarioside A 108-125 interleukin 6 Homo sapiens 10-14 30508574-4 2019 N3 PUFAs (DHA 8.7 muM/EPA14.21 muM) or clozapine (3 muM) significantly reduced poly I:C-induced increase in iNOS, NFkB (p50/p65), IL-6 and nitrite when compared to non-treated cells. Poly I-C 79-87 interleukin 6 Homo sapiens 130-134 31069136-7 2019 Nonetheless, poly(I:C)-mediated tumor regression and change in the myeloid cell landscape was dependent on IL-6. Poly I-C 13-22 interleukin 6 Homo sapiens 107-111 30838176-8 2019 In line with these results, ERK (U0126) and p38 MAPK (SB203580) specific signaling inhibitors suppressed hIL-6 expression and attenuated cell growth in PEL cells. SB 203580 54-62 interleukin 6 Homo sapiens 105-110 31123968-8 2019 Summarizing, cotreatment with cilostazol and celecoxib exhibited a synergistic increase in IL-10 production and SOCS3 expressions, thereby resulted in synergistic decreases in IL-1beta mRNA, IL-6 mRNA expression and TNF-alpha synthesis in association with synergistic decreases in COX-2 and PGE2 protein expression in the RA synovial fibroblasts. Cilostazol 30-40 interleukin 6 Homo sapiens 191-195 31795177-7 2019 We found that low dietary ORAC was associated with a significant increase in CRC in the group with elevated IL-6 levels (total ORAC OR Q4 vs. Q1, 95% CI = 4.34, 3.12-6.02, p < 0.001; total phenolics = 4.61, 3.33-6.39, p < 0.001). phenolic acid 192-201 interleukin 6 Homo sapiens 108-112 34055311-5 2019 Astilbin also inhibited the I/R-induced upregulation of pro-inflammatory mediators (TNFalpha, IL-1beta, IL-6). astilbin 0-8 interleukin 6 Homo sapiens 104-108 31542660-0 2019 The organochlorine pesticides pentachlorophenol and dichlorodiphenyltrichloroethane increase secretion and production of interleukin 6 by human immune cells. Hydrocarbons, Chlorinated 4-18 interleukin 6 Homo sapiens 121-134 30407866-6 2019 On the contrary, challenge with supraphysiological concentrations (10-25 mM), as might be used therapeutically, of propionate or butyrate in combination with TNFalpha resulted in substantially greater IL-6 and CXCL8 release from HLFs and ASM cells than challenge with TNFalpha alone, demonstrating synergistic effects. Butyrates 129-137 interleukin 6 Homo sapiens 201-205 35399295-10 2022 The mRNA levels for IL-1b, IL-6, and TNF-alpha increased significantly at the end of 2-h exposure of A549 cells to the positive control AgNP aerosols. agnp 136-140 interleukin 6 Homo sapiens 27-31 30808838-5 2019 RESULTS: We found that poly IC induced the expression of RIG-I, MDA5 and IL-6 via TLR3/IFN-beta signaling in GECs. Poly I-C 23-30 interleukin 6 Homo sapiens 73-77 31683341-0 2019 Treatment with Metformin and Combination of Metformin Plus Pioglitazone on Serum Levels of IL-6 and IL-8 in Polycystic Ovary Syndrome: A Randomized Clinical Trial. Pioglitazone 59-71 interleukin 6 Homo sapiens 91-95 31683341-14 2019 Combination of metformin and pioglitazone therapy was more effective as compared to metformin alone in reducing the levels of IL-6 and IL-8 as well as insulin resistance in PCOS. Pioglitazone 29-41 interleukin 6 Homo sapiens 126-130 35191475-9 2022 Cordycepin treatment resulted in around 50% inflammatory cytokine production (e.g., IL-6 and IL-1beta) and about 60% immune cell infiltration (e.g., Th17 cells) when compared to vehicle control group. cordycepin 0-10 interleukin 6 Homo sapiens 84-88 31520987-0 2019 The dynamic of TNF and IL6 gene expression in chronic myeloid leukemia patients reveals early responders to imatinib. Imatinib Mesylate 108-116 interleukin 6 Homo sapiens 23-26 30483779-6 2019 Activation of PPAR-gamma by pioglitazone resulted in significantly increased expression of visfatin, which abrogated the inhibitory effect of IL-6 on visfatin in BeWo cells. Pioglitazone 28-40 interleukin 6 Homo sapiens 142-146 30483779-7 2019 Furthermore, treatment using pioglitazone alone increased the expression and secretion of the visfatin protein, compared with the control or IL-6 alone group. Pioglitazone 29-41 interleukin 6 Homo sapiens 141-145 35023009-13 2022 CONCLUSION: The direct association of neopterin level with IL-6 promoter polymorphism at - 174G/C (rs1800795) hotspot indicated the role of inflammation in CVD pathogenesis in the Saudi population. Neopterin 38-47 interleukin 6 Homo sapiens 59-63 31484895-4 2019 The Jak1/2 inhibitor ruxolitinib can simultaneously inhibit the signaling pathway of multiple cytokines with relevance for GvHD, such as interferon (IFN-gamma), IL-2, and IL-6. ruxolitinib 21-32 interleukin 6 Homo sapiens 171-175 31908586-6 2019 DNA methylation level of IL-6 promoter in peripheral leukocytes were measured using bisulphite conversion and MethyLight assay. hydrogen sulfite 84-94 interleukin 6 Homo sapiens 25-29 30947576-4 2019 A blockade of ERK signaling with trametinib suppressed the combination treatment-induced ERK activation, reduced IL-6 mRNA expression, and downregulated IL-6R mRNA expression, resulting in an improvement in the antitumor effect. trametinib 33-43 interleukin 6 Homo sapiens 113-117 31299628-8 2019 The performance of SERS LFA was demonstrated by detection of IL-6 in unprocessed whole blood with comparable performance of the conventional enzyme-linked immunosorbent assay (ELISA). sers lfa 19-27 interleukin 6 Homo sapiens 61-65 35080634-7 2022 RESULTS: We found that chronic clozapine treatment in patients with schizophrenia resulted in the abnormal expression of serum cytokines, such as IL-2, IL-6, IL-17, and TNF-alpha, compared with the healthy controls. Clozapine 31-40 interleukin 6 Homo sapiens 152-156 31598393-6 2019 Current research on targeting CAF-CSC crosstalk could be classified into (i) specific depletion of CAF subpopulations that have CSC-supporting activities and (ii) targeting molecular signaling in CAF-CSC crosstalk, such as the IL6/STAT3, TGF-beta/SDF-1/PI3K, WNT/beta-catenin, HGF/cMET and SHH/Hh pathways. CAF protocol 30-33 interleukin 6 Homo sapiens 227-230 30262435-3 2018 In mechanism studies, we found that NED induction in A549R26-1 and H157R24-1 cells was accompanied by increased intracellular cAMP and IL-6 levels. ned 36-39 interleukin 6 Homo sapiens 135-139 30463189-3 2018 The results showed that COS pretreatment for 12 h significantly ameliorated lipid accumulation in HepG2 cells exposed to PA for 24 h, accompanied by a reversing of the upregulated mRNA expression of proinflammatory cytokines (IL-6, MCP-1, TNF-alpha) and glucolipid metabolism-related regulators (SCD-1, ACC1, PCK1-alpha). Palmitic Acid 121-123 interleukin 6 Homo sapiens 226-230 35125876-12 2022 In the LPS-stimulated macrophages, IBA reduced the expression of IL-4 and IL-6, and ILA inhibited the upregulation of IL-6. indolebutyric acid 35-38 interleukin 6 Homo sapiens 74-78 29939445-14 2018 Ruxolitinib also significantly inhibited the production of IL-6, TNF-alpha and MCP-1 as induced by A23817 and substance P. Selective STAT5 inhibition with pimozide resulted in diminished degranulation and inhibition of cytokine production as induced by A23817 and substance P. CONCLUSIONS & CLINICAL RELEVANCE: This study demonstrates that the JAK1/JAK2 inhibitor ruxolitinib can inhibit MCactivity, possibly through prevention of STAT5 activation. ruxolitinib 0-11 interleukin 6 Homo sapiens 59-63 31176725-8 2019 However, 13-HpOTrE treatment reduced the release of interleukin-6, bringing it closer to the level of tumor-free constructs. 13-HpOTrE 9-18 interleukin 6 Homo sapiens 52-65 35164046-6 2022 In addition, the inhibitory effects of both doses of MiodesinTM (10 microg/mL and 200 microg/mL) resulted in reduced secretion of interleukin-1beta (IL-1beta), IL-6, IL-8, tumor necrosis factor alpha (TNF-alpha) (24 h, 48 h, and 72 h) and CCL2, CCL3, and CLL5 (p < 0.05) by VK2 E6/E7 cells. miodesintm 53-63 interleukin 6 Homo sapiens 160-164 31322196-5 2019 The expression levels of interleukin (IL)-6, IL-8 and monocyte chemoattractant protein-1 increased following treatment with S100A8 and S100A9, and the increase was significantly blocked by specific signaling pathway inhibitors, including toll-like receptor 4 inhibitor (TLR4i), rottlerin, PD98059, SB203580 and BAY-11-7085. SB 203580 298-306 interleukin 6 Homo sapiens 25-43 30075293-4 2018 The cytokines TNF-alpha and IL-6 directly cause BBB dysfunction measured by a decrease in transendothelial electrical resistance, an increase in sodium fluorescein permeability, and a decrease in cell polarity, providing a link between neuroinflammation and specific aspects of BBB breakdown. Fluorescein 145-163 interleukin 6 Homo sapiens 28-32 30218778-8 2018 A substantially increased inflammatory response to CoA-based ES was observed, with upregulation of IL-6 expression and a significant M2 macrophage presence. coenzyme A 51-54 interleukin 6 Homo sapiens 99-103 30402044-2 2018 Neostigmine suppressed (p < 0.05) LPS-stimulated synthesis of cytokines such as interleukin- (IL-) 1beta, IL-6, and tumor necrosis factor (TNF) alpha in the POA, and this effect was similar to that induced by the treatment with systemic AChE inhibitor-donepezil (2.5 mg/animal). lps 37-40 interleukin 6 Homo sapiens 109-113 30390734-37 2018 Nicotinamide can inhibit cytokine release (IL-1, IL-6, IL-8, and TNF-alpha) from immune cells, inhibit chemotaxis and degranulation of immune cells, inhibit lymphocyte blast transformation, and suppress T-cell activity (6). Niacinamide 0-12 interleukin 6 Homo sapiens 49-53 31534438-6 2019 We found that poly I:C induced increased expression of the proinflammatory cytokines IL1beta, IL6, CXCL8, and TNF and IFN-beta1 in AECs from both control subjects and COPD patients. Poly I-C 14-22 interleukin 6 Homo sapiens 94-97 35164046-7 2022 In the same way, COX-1 MiodesinTM inhibited LPS-induced hyperactivation of KLE cells, as demonstrated by reduced secretion of IL-1beta, IL-6, IL-8, TNF-alpha (24 h, 48 h, and 72 h) and CCL2, CCL3, and CLL5 (p < 0.05). miodesintm 23-33 interleukin 6 Homo sapiens 136-140 35126375-0 2021 A Novel Humanized Anti-Interleukin-6 Antibody HZ0408b With Anti-Rheumatoid Arthritis Therapeutic Potential. hz0408b 46-53 interleukin 6 Homo sapiens 23-36 31282647-11 2019 Furthermore, intra-VTA injection of LPS-RS or IL-6 neutralizing antibody suppressed METH-induced elevation of extracellular NAc dopamine. nac dopamine 124-136 interleukin 6 Homo sapiens 46-50 30102465-7 2018 PA, but not OA, enhances the production of IL-6 and IL-8 in response to TNF-alpha. Palmitic Acid 0-2 interleukin 6 Homo sapiens 43-47 30102465-10 2018 PA enhances the expression of MCP-1, IL-6, and COX-2 genes, while POA downregulates these genes, decreases expression of NFkappaB, and upregulates PPAR-alpha gene expression. Palmitic Acid 0-2 interleukin 6 Homo sapiens 37-41 35048572-6 2022 We summarize here the findings of two studies published in 2021, one reporting the benefits of combining GC with mycophenolate mofetil in immune thrombocytopenia, the other suggesting that blockage of interleukin-6 may decrease disease progression in systemic sclerosis with lung involvement. Mycophenolic Acid 113-134 interleukin 6 Homo sapiens 201-214 30214578-6 2018 Additionally, butyrate treatment induced the phosphorylation of extracellular signal-regulated kinase, tumor protein 38, c-Jun NH2-terminal kinase and nuclear factor-kappaB (NF-kappaB) p65, and then promoted the pro-inflammatory cytokine tumor necrosis factor-alpha, but not interleukin 6 secretion in SW480 and CT26 cells. Butyrates 14-22 interleukin 6 Homo sapiens 275-288 31136945-0 2019 Imiquimod and interferon-alpha augment monocyte-mediated astrocyte secretion of MCP-1, IL-6 and IP-10 in a human co-culture system. Imiquimod 0-9 interleukin 6 Homo sapiens 87-91 2788520-9 1989 However, we could only detect IL6 message in cells incubated with LPS under "superinduction" conditions with cycloheximide, consistent with lower levels of IL6 biological activity in response to LPS compared to IL1 stimulation. Cycloheximide 109-122 interleukin 6 Homo sapiens 30-33 30657173-7 2019 The protein production of the proinflammatory cytokines TNF-alpha, interferon gamma, IL-1beta, IL-6 and IL-17A was significantly inhibited by adalimumab, infliximab, ustekinumab, prednisolone (all P < 0 001) and rituximab (P = 0 0071), but not by secukinumab (P = 0 0663). Prednisolone 179-191 interleukin 6 Homo sapiens 95-99 30515817-5 2019 IL-6 and IL-8 upregulation were blocked by broad-acting HDAC inhibitors SAHA and LBH589. Panobinostat 81-87 interleukin 6 Homo sapiens 0-4 31278797-0 2019 TERT inhibition leads to reduction of IL-6 expression induced by palmitic acid and interferes with the protective effects of tibolone in an astrocytic cell model. Palmitic Acid 65-78 interleukin 6 Homo sapiens 38-42 31365708-12 2019 IL-6 levels were higher in O-CP and O-Ctrl groups than in the nO-Ctrl group (P<0.05). o-cp 27-31 interleukin 6 Homo sapiens 0-4 31330988-5 2019 The enzyme-linked immunosorbent assay (ELISA) and quantitative real time polymerase chain reaction (qRT-PCR) results demonstrated stronger inhibitory effects of pitavastatin on the cytokine production of T cells activated by phorbol 12-myristate 13-acetate (PMA) plus ionomycin, including interleukin (IL)-2, interferon (IFN)-gamma, IL-6, and tumor necrosis factor alpha (TNF-alpha). pitavastatin 161-173 interleukin 6 Homo sapiens 333-337 31333667-4 2019 PolyI:C increased the expression of interferon-beta (IFN-beta), interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoattractant protein (MCP-1), and interleukin-1beta (IL-1beta) in HCT116 cells, and these up-regulations were significantly altered when cells were pre-stimulated with LAB isolated from Korean fermented foods. Poly I-C 0-7 interleukin 6 Homo sapiens 64-77 31333667-4 2019 PolyI:C increased the expression of interferon-beta (IFN-beta), interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoattractant protein (MCP-1), and interleukin-1beta (IL-1beta) in HCT116 cells, and these up-regulations were significantly altered when cells were pre-stimulated with LAB isolated from Korean fermented foods. Poly I-C 0-7 interleukin 6 Homo sapiens 79-83 30952010-4 2019 Pretreatment with the DNMT inhibitor 5-Aza-2"-deoxycytidine (5-Aza-CdR) significantly enhanced the expression of the inflammatory cytokines IL-6 and IL-8 in LPS-stimulated hDPCs, indicating that DNA methylation may play a role in hDPC inflammation. Decitabine 37-59 interleukin 6 Homo sapiens 140-144 31181780-8 2019 A reduction in IL-6 secretion in ALI-cultured Calu-3 cells treated with LE was also observed. Leu-Glu 72-74 interleukin 6 Homo sapiens 15-19 32215295-9 2020 The obtained results revealed that: 1) increased expression of IL-6, NO and Caspase-3 in serum and cerebrospinal fluid in patients after TBI, and decreased PPARgamma in brain tissue; 2) pioglitazone could improve neurobehavioral and reduce brain edema in rats after TBI; 3) the protective effect of pioglitazone was achieved by activating PPARgamma and reducing NF-kappaB and IL-6. Pioglitazone 186-198 interleukin 6 Homo sapiens 63-67 33911592-7 2019 Results: When skin keratinocytes were pre-treated with SAA, it significantly inhibited poly (I:C)-induced expression of inflammatory cytokines including interleukin (IL)-1beta, IL-6, IL-8, tumor necrosis factor-alpha, and CCL20. Poly I-C 87-97 interleukin 6 Homo sapiens 177-181 30715797-4 2019 Stimulation with poly (I:C) LMW induces a 15- to 17-fold increase in IL-6 production by HNEC-ALI cells. Poly I-C 17-31 interleukin 6 Homo sapiens 69-73 30466341-4 2019 Results: LPS-induced expressions of pro-inflammatory genes IL-6, IL-8, TNF-alpha, IL-1beta, MCP-1, MMP-9, iNOS and COX-2 were significantly and dose-dependently suppressed by XAV939. XAV939 175-181 interleukin 6 Homo sapiens 59-63 30988370-5 2019 Herein the systematic removal of carbons from either the hydroxy fatty acid or fatty acid regions of the most studied FAHFA, palmitic acid ester of 9-hydroxystearic acid (9-PAHSA), was achieved and these synthetic, abridged analogs were tested for their ability to attenuate IL-6 production. isopropyl palmitate 125-144 interleukin 6 Homo sapiens 275-279 30902899-9 2019 injection of CCK8S suppressed the IMQ-induced psoriatic inflammation accompanied by reduced mRNA expression of IL-17, IL-22, and IL-6 but not of IL-23. Imiquimod 34-37 interleukin 6 Homo sapiens 129-133 30792116-5 2019 Terpinolene and alpha-phellandrene significantly increased the migration and proliferation of fibroblasts and suppressed the pro-inflammatory cytokines IL-6 and TNF-alpha in a dose-dependent manner. alpha phellandrene 16-34 interleukin 6 Homo sapiens 152-156 31008484-6 2019 EP1/EP3 agonist 17-phenyl-trinor-PGE2 stimulated IL-6 and TNFalpha whilst suppressing IL-1beta and CXCL8 output. 17-phenyltrinorprostaglandin E2 16-37 interleukin 6 Homo sapiens 49-53 30974307-5 2019 RESULTS: HP group showed significantly elevated levels of interleukin (IL)-6 as compared to HNP group. Hematoporphyrins 9-11 interleukin 6 Homo sapiens 58-76 30974307-7 2019 CONCLUSION: Postpartum period appears to be a state of altered immune functioning considering the elevated level of IL-6 in both HP and PP group. Hematoporphyrins 129-131 interleukin 6 Homo sapiens 116-120 30690290-0 2019 Palmitate-induced IL6 expression ameliorated by chicoric acid through AMPK and SIRT1-mediated pathway in the PBMCs of newly diagnosed type 2 diabetes patients and healthy subjects. chicoric acid 48-61 interleukin 6 Homo sapiens 18-21 30404019-5 2019 Nonselective P2 receptor antagonist and selective P2Y2 receptor antagonists, kaempferol and AR-C118925XX, significantly inhibited ATP-induced IL-6 production and phosphorylation of p38 in SSc fibroblasts. AR-C118925 92-104 interleukin 6 Homo sapiens 142-146 30850240-12 2019 Modelling revealed associations between systemic symptoms and increased levels of CRP and IL-6 after the first HBsAg-AS01B or HBsAg-Alum immunization. as01b 117-122 interleukin 6 Homo sapiens 90-94 30850240-15 2019 CONCLUSIONS: IL-6 and IFN-gamma signals were associated with systemic reactogenicity following administration of AS01B-adjuvanted vaccine. as01b 113-118 interleukin 6 Homo sapiens 13-17 30858902-11 2019 In the lipopolysaccharide-stimulated group, butyrate and docosahexaenoic acid attenuated IL-6 mRNA upregulation by lipopolysaccharide. Butyrates 44-52 interleukin 6 Homo sapiens 89-93 30863452-6 2019 Systematic analysis of the created TCMP-Compound-Target-Disease network revealed that DHI and NXT shared common targets such as PTGS2, F2, ADRB1, IL6, ALDH2, and CCL2, which were involved in the vasomotor system regulation, blood-brain barrier disruption, redox imbalance, neurotrophin activity, and brain inflammation. TCMP 35-39 interleukin 6 Homo sapiens 146-149 30571852-2 2019 To explore the mechanism of ruxolitinib"s limited effect, we examined the JAK1/2 mediated induction of proliferation related ERK1/2 and AKT signaling by proinflammatory interleukin-6 (IL-6) in MPN granulocytes and JAK2V617F mutated human erythroleukemia (HEL) cells. ruxolitinib 28-39 interleukin 6 Homo sapiens 169-182 30571852-2 2019 To explore the mechanism of ruxolitinib"s limited effect, we examined the JAK1/2 mediated induction of proliferation related ERK1/2 and AKT signaling by proinflammatory interleukin-6 (IL-6) in MPN granulocytes and JAK2V617F mutated human erythroleukemia (HEL) cells. ruxolitinib 28-39 interleukin 6 Homo sapiens 184-188 30571852-6 2019 Regarding a cell cycle, we found that IL-6 reduction of HEL cells percentage in G2M phase was reversed by ruxolitinib (2.6 fold). ruxolitinib 106-117 interleukin 6 Homo sapiens 38-42 30571852-8 2019 Regarding DNA replication, we found that ruxolitinib prevented the IL-6 augmentation of MPN granulocytes frequency in the S phase of the cell cycle (up to 2.9 fold). ruxolitinib 41-52 interleukin 6 Homo sapiens 67-71 30548778-11 2019 Pearson correlation analysis showed IL-1beta was positively correlated with CBL (P = .0079), whereas IL-6 showed positive correlation with both BOP (P = .0019) and CBL (P = .015) among obese patients. bop 144-147 interleukin 6 Homo sapiens 101-105 30578916-6 2019 Treatment of human primary monocytes with the lignans during their maturation to dendritic cells did not have any effect on the appearance of surface markers HLA-DR and CD86 but schisandrin B and schisandrin C suppressed the secretion of cytokines interleukin (IL)-6, IL-10 and IL-12 by the mature dendritic cells. schizandrin C 196-209 interleukin 6 Homo sapiens 248-266 30578916-8 2019 In THP-1 cells, schisandrin B and schisandrin C reduced the IL-6 and IL-12 production triggered by E. coli lipopolysaccharide and IL-12 production induced by an infection with Chlamydia pneumoniae. schizandrin B 16-29 interleukin 6 Homo sapiens 60-64 30578916-8 2019 In THP-1 cells, schisandrin B and schisandrin C reduced the IL-6 and IL-12 production triggered by E. coli lipopolysaccharide and IL-12 production induced by an infection with Chlamydia pneumoniae. schizandrin C 34-47 interleukin 6 Homo sapiens 60-64 30242542-11 2019 Moreover, NF-kappaB inhibitor restored the elevation of TNF-alpha, IL-1beta, IL-6, and MMP-9 induced by miR-410-3p inhibition. p-Bis(2-chloroethyl)amino-o-methoxyphenylalanine 112-114 interleukin 6 Homo sapiens 77-81 30696600-5 2019 Additionally, silicon may induce mononuclear cells to secrete proinflammatory cytokines IL-1beta, IL-6 and TNF-alpha. Silicon 14-21 interleukin 6 Homo sapiens 98-102 30669636-5 2019 In addition, we determined that DHE-glycoside beta-anomers showed strong inhibitory activity towards pro-inflammatory cytokine mRNA and protein expression, including that of TNF-alpha, IL-6, and IL-1beta- in stimulated HaCaT cells. dhe-glycoside 32-45 interleukin 6 Homo sapiens 185-189 30630559-18 2019 CONCLUSION: Compared with midazolam-remifentanil intravenous anaesthesia, the dezocine-remifentanil method has a better analgesic effect, shorter wake-up time, and can effectively regulate the expression of inflammatory cytokines TNF-&alpha; and IL-6. dezocine 78-86 interleukin 6 Homo sapiens 250-254 30959503-11 2019 SUL reduced the uremic serum-induced secretion of all solutes: IL6 -24%, p < 0.05; ICAM-1 -43%, p < 0.01; VEGF -38%, p < 0.01; vWF -23%, p < 0.01; t-PA -49%, p < 0.01, and MMP9 -25%, p < 0.05. glucuronyl glucosamine glycan sulfate 0-3 interleukin 6 Homo sapiens 63-66 30394001-7 2018 Simultaneous GNRs, dODN, and thermotherapy show synergic effect on the reduction of TNF-alpha and IL-6 in inflamed macrophages and blood vessel cells. dodn 19-23 interleukin 6 Homo sapiens 98-102 30538945-7 2018 Results: The production of IL-6 significantly increased in the presence of polyinosinic-polycytidylic acid (poly(I:C)) as the TLR3 ligand. Poly I-C 75-106 interleukin 6 Homo sapiens 27-31 30538945-7 2018 Results: The production of IL-6 significantly increased in the presence of polyinosinic-polycytidylic acid (poly(I:C)) as the TLR3 ligand. Poly I-C 108-116 interleukin 6 Homo sapiens 27-31 30380512-4 2018 Osthole repressed ox-LDL-induced release of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, and IL-6 in HUVECs. osthol 0-7 interleukin 6 Homo sapiens 113-117 30713180-1 2018 AIM: Evaluation of the effect of glucosamine-chondroitin combination, tramadol, and sodium hyaluronic acid in temporomandibular joint (TMJ) disorders and its impact on the expression of various cytokines such as IL-6, IL-1beta, TNF-alpha, and PGE2. Chondroitin 45-56 interleukin 6 Homo sapiens 212-216 30295964-4 2018 RESULTS: Poly (I:C) induced the expression of the interferon-stimulated genes (ISG) MxA, OAS2 and APOBEC3G, and the cytokines MCP-1, IL-8, IL-6, CCL20, IFNbeta and RANTES by fibroblasts from all three sites. Poly I-C 9-19 interleukin 6 Homo sapiens 139-143 29790117-7 2018 IL6 expression was higher in the three types of cells after transfecting with miR-155-3p mimic. p-Bis(2-chloroethyl)amino-o-methoxyphenylalanine 86-88 interleukin 6 Homo sapiens 0-3 29780145-4 2018 Based on her cognitive impairment, muscle rigidity, and high levels of interleukin-6 in the cerebrospinal fluid, we believed she had developed a complication of a neuropsychiatric disease and administered corticosteroids and intravenous cyclophosphamide therapy. Cyclophosphamide 237-253 interleukin 6 Homo sapiens 71-84 29800615-9 2018 Levels of inflammatory cytokines IL-8, IL-10, IL-6, TNFR2, INF-alpha, and INF-beta were reduced after ruxolitinib treatment. ruxolitinib 102-113 interleukin 6 Homo sapiens 46-50 30022772-7 2018 The gamma-irradiation-induced increase in IL-6 and IL-8 production was suppressed by apyrase (ecto-nucleotidase), NF157 (selective P2Y11 receptor antagonist) and SB203580 (p38 MAPK inhibitor). SB 203580 162-170 interleukin 6 Homo sapiens 42-46 32254503-3 2018 The OECT gate electrode is functionalized with an oligo(ethylene glycol)-terminated self-assembled alkanethiolate monolayer (SAM) for both the immobilization of anti IL-6 antibodies and the inhibition of non-specific biomolecule binding. oligo(ethylene glycol) 50-72 interleukin 6 Homo sapiens 166-170 30185897-3 2018 miR-301a was found to be upregulated during arsenic-induced BEAS-2B transformation and the overexpression of miR-301a was dependent on IL-6/STAT3 signaling. Arsenic 44-51 interleukin 6 Homo sapiens 135-139 30180409-9 2018 Conclusion: CVVHDF as an adjuvant therapy can rapidly reduce the levels of IL-6 and TNF-alpha,and improve the organ functions in children with KD complicated with MODS. cvvhdf 12-18 interleukin 6 Homo sapiens 75-79 29852208-9 2018 Escitalopram significantly decreased CRP and IL-6 levels (both P < 0.05). Citalopram 0-12 interleukin 6 Homo sapiens 45-49 29948421-7 2018 The cytotoxicity of IL-6 signaling blockers in ESCC cells was analyzed by MTT assay. monooxyethylene trimethylolpropane tristearate 74-77 interleukin 6 Homo sapiens 20-24 29569260-8 2018 Of note, the reduced level of TNF-alpha, IL-6 as well as Leptin and the production of Adiponectin by miR-375 inhibitors was significantly reversed by silencing of AdipoR2 in PA-induced HepG2 cells. Palmitic Acid 174-176 interleukin 6 Homo sapiens 41-45 30154906-5 2018 The results showed that KJS018A significantly inhibited the proliferation of hepatic malignant cells and downregulated levels of IL-6 and Cox-2. kjs018a 24-31 interleukin 6 Homo sapiens 129-133 30154906-6 2018 Furthermore, KJS018A diminished the effect of PMA, an inflammatory inducer via IL-6/STAT3/Cox-2 pathway. kjs018a 13-20 interleukin 6 Homo sapiens 79-83 30054566-0 2018 Primary human nasal epithelial cells: a source of poly (I:C) LMW-induced IL-6 production. Poly I-C 50-64 interleukin 6 Homo sapiens 73-77 30116631-7 2018 Then we tested which of cell signal pathways regulating the production of IL-6 were activated when we added MG132 into the medium by Western blot and electrophoretic mobility shift assays (EMSA). benzyloxycarbonylleucyl-leucyl-leucine aldehyde 108-113 interleukin 6 Homo sapiens 74-78 30116631-9 2018 Results: MG132 decreased the secretion of MCP-1 in the culture medium of RPE, but it increased the expression of IL-6 mRNA in RPE and IL-6 protein level in the culture medium of RPE. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 9-14 interleukin 6 Homo sapiens 113-117 30116631-9 2018 Results: MG132 decreased the secretion of MCP-1 in the culture medium of RPE, but it increased the expression of IL-6 mRNA in RPE and IL-6 protein level in the culture medium of RPE. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 9-14 interleukin 6 Homo sapiens 134-138 30116631-11 2018 More importantly, the effect of MG132 on upregulating the levels of IL-6 was inhibited by SB203580, an inhibitor of P38 MAP kinases. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 32-37 interleukin 6 Homo sapiens 68-72 30116631-11 2018 More importantly, the effect of MG132 on upregulating the levels of IL-6 was inhibited by SB203580, an inhibitor of P38 MAP kinases. SB 203580 90-98 interleukin 6 Homo sapiens 68-72 30116631-12 2018 But the JNK inhibitor, SP600125, cannot prevent the effect of upregulating the levels of IL-6 by MG132 in the RPE culture medium. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 97-102 interleukin 6 Homo sapiens 89-93 30116631-13 2018 Conclusions: We concluded that the proteasome inhibitor, MG132, upregulates IL-6 production in RPE cells through the activation of P38 MAPKs. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 57-62 interleukin 6 Homo sapiens 76-80 29587166-7 2018 The fold changes of LPS-induced secretion of IL-6 and TNF-alpha from monocytes cultured for 6 and 18 h were all lower in the patient groups, and that was true for IL-1beta as monocytes cultured for 18 h. LIMITATIONS: Given the gap between the results of in vitro experiments and the actual response that happens in vivo when the immune system encounters pathogens from the external world, future research should include in vivo methods to test the results of the current study. lps 20-23 interleukin 6 Homo sapiens 45-49 30002661-4 2018 Baricitinib also suppressed the differentiation of human B cells into plasmablasts by B cell receptor and type-I IFN stimuli and inhibited the production of interleukin (IL)-6 from B cells. baricitinib 0-11 interleukin 6 Homo sapiens 157-175 30002661-6 2018 In addition, baricitinib inhibited Th1 differentiation after IL-12 stimulation and Th17 differentiation by TGF-beta1, IL-6, IL-1beta, and IL-23 stimulation. baricitinib 13-24 interleukin 6 Homo sapiens 118-122 29940605-9 2018 BK treatment significantly enhanced TNF-alpha, IL-1beta, and IL-6 expression levels, and these enhancements were reduced by propofol treatment in a dose-dependent manner. Propofol 124-132 interleukin 6 Homo sapiens 61-65 28923363-4 2018 In fact, pure flavonoids (e.g., quercetin, genistein, hesperetin, epigallocatechin-3-gallate) or enriched-extracts, can reduce the expression of pro-inflammatory cytokines (IL-6, TNF-alpha, IL-1beta and COX-2), down-regulate inflammatory markers and prevent neural damage. hesperetin 54-64 interleukin 6 Homo sapiens 173-177 29608374-17 2018 Serum IL-1beta, IL-6, and TNF-alpha were higher in the AMS group than in the non-AMS group. ams 55-58 interleukin 6 Homo sapiens 16-20 29608374-20 2018 CONCLUSIONS: Acute phase proteins and inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) show significant changes between the AMS group and the non-AMS group. ams 130-133 interleukin 6 Homo sapiens 72-76 29608374-20 2018 CONCLUSIONS: Acute phase proteins and inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) show significant changes between the AMS group and the non-AMS group. ams 152-155 interleukin 6 Homo sapiens 72-76 29106735-6 2018 IL-6 alone had a mild dose-dependent effect; co-stimulation with sIL-6R significantly enhanced this effect, whereas it was completely abolished by the addition of IL-6R blocking antibody (P < 0.05). sil-6r 65-71 interleukin 6 Homo sapiens 0-4 29805673-0 2018 Anesthetic drug propofol inhibits the expression of interleukin-6, interleukin-8 and cyclooxygenase-2, a potential mechanism for propofol in suppressing tumor development and metastasis. Propofol 129-137 interleukin 6 Homo sapiens 52-65 29805673-2 2018 The present study demonstrated that propofol may suppress the proliferation of MCF-7 cells and inhibit the expression of interleukin (IL)-6 and IL-8. Propofol 36-44 interleukin 6 Homo sapiens 121-139 29805673-4 2018 Therefore, the mechanism of propofol in suppressing tumor development and metastasis may be associated with the inhibition of IL-6, IL-8 and COX-2. Propofol 28-36 interleukin 6 Homo sapiens 126-130 29737177-1 2018 The lactone derivative of the epoxyisoprostane EC is a highly effective inhibitor of the secretion of the proinflammatory cytokine IL-6. Lactones 4-11 interleukin 6 Homo sapiens 131-135 29868030-3 2018 Cyclic dinucleotides recognition enables classical dendritic cells (cDCs) that predominantly express CD103 to induce Th17 lymphocytes in an IL-6/IL-1beta-dependent manner in gut. cyclic dinucleotides 0-20 interleukin 6 Homo sapiens 140-144 29743895-7 2018 50 and 100 muM osthole also blocked the generation of IL-6 and TNF-alpha in IL-1beta-stimulated SW982 cells. osthol 15-22 interleukin 6 Homo sapiens 54-58 29575797-6 2018 RESULT: NTHi induced production of large amounts of IL-1beta, IL-6, and IL-8 in adult-control BAL cells, however BAL cells from PBB airways appeared refractory to NTHi stimulation. nthi 8-12 interleukin 6 Homo sapiens 62-66 29908644-6 2018 RESULTS: TNF-alpha, IL-8 and IL-6 mRNAs were elevated in CdCl2-treated JEG-3 cells. Cadmium Chloride 57-62 interleukin 6 Homo sapiens 29-33 29854627-4 2018 Thalidomide and carboplatin induced up-regulation of the expression of p53, tumor necrosis factor-alpha and interleukin-6 in brain and kidney. Carboplatin 16-27 interleukin 6 Homo sapiens 108-121 29743982-8 2018 Before training, a reverse correlation between IL-6 and total oxidative capacity (TOC) levels (p < 0.05) was found, while after training between IL-6 and calcidiol levels (p <= 0.001). Calcifediol 157-166 interleukin 6 Homo sapiens 148-152 29615908-7 2018 Acetate, butyrate and propionate reduced IL-6 and IL-8 levels and the magnitude was dependent on the incubation times. Butyrates 9-17 interleukin 6 Homo sapiens 41-45 29562405-11 2018 Conclusions: In total arch replacement, intravenous penehyclidine hydrochloride injection may decrease the release of serum TNF-alpha, IL-6, IL-1, improve oxygenation index, reduce lung ischemia-reperfusion injury, shorten the time of ventilator support and ICU stay after operation, and thus improve the prognosis of patients. Penequine hydrochloride 52-79 interleukin 6 Homo sapiens 135-139 33418784-7 2018 In contrast to class C CpG ODNs, which also simultaneously induce IFN-alpha and IL-6, the ratio of IFN-alpha and IL-6 induced by PEI-CpG ODN NPs could be regulated by changing the N/P ratio. Polyethyleneimine 129-132 interleukin 6 Homo sapiens 80-84 33418784-7 2018 In contrast to class C CpG ODNs, which also simultaneously induce IFN-alpha and IL-6, the ratio of IFN-alpha and IL-6 induced by PEI-CpG ODN NPs could be regulated by changing the N/P ratio. Polyethyleneimine 129-132 interleukin 6 Homo sapiens 113-117 29693005-0 2018 Suppression of IL-6 Gene by shRNA Augments Gemcitabine Chemosensitization in Pancreatic Adenocarcinoma Cells. gemcitabine 43-54 interleukin 6 Homo sapiens 15-19 29693005-4 2018 Herein, we investigated whether suppression of IL-6 could augment gemcitabine sensitivity in the PANC-1 cells. gemcitabine 66-77 interleukin 6 Homo sapiens 47-51 29693005-7 2018 In addition, suppression of IL-6 remarkably promoted antitumor effect of gemcitabine, indicating that the combination of shRNA targeting IL-6 with gemcitabine may provide a potential clinical approach for pancreatic cancer therapy. gemcitabine 73-84 interleukin 6 Homo sapiens 28-32 29693005-7 2018 In addition, suppression of IL-6 remarkably promoted antitumor effect of gemcitabine, indicating that the combination of shRNA targeting IL-6 with gemcitabine may provide a potential clinical approach for pancreatic cancer therapy. gemcitabine 73-84 interleukin 6 Homo sapiens 137-141 29693005-7 2018 In addition, suppression of IL-6 remarkably promoted antitumor effect of gemcitabine, indicating that the combination of shRNA targeting IL-6 with gemcitabine may provide a potential clinical approach for pancreatic cancer therapy. gemcitabine 147-158 interleukin 6 Homo sapiens 28-32 29286161-7 2018 At a concentration of 2.22 microM, astilbin decreased the mRNA expression levels of IL-6, IL-17A and IL-22 in lipopolysaccharide (LPS)-induced HaCaT cells by 89, 69.1 and 69.3%, respectively. astilbin 35-43 interleukin 6 Homo sapiens 84-88 29541375-6 2018 The structure-activity relationship is discussed and suggested that 3-substitution on the aryl ring at C4 position of the pyrano[3,2-c]quinolone structural motif seems to be an important position for both TNF-alpha and IL-6 inhibition and anticancer activity as well. pyrano[3,2-c]quinolone 122-144 interleukin 6 Homo sapiens 219-223 29107850-5 2018 The increase of interleukin-6 during the 24h after implantation was associated with higher levels of pentadecanoic acid (C15:0) and lower levels of alpha-linolenic acid (C18:3 N3). pentadecanoic acid 101-119 interleukin 6 Homo sapiens 16-29 29117589-6 2018 Additionally, long-term exposure of MC-LR at low concentration remarkably promoted the expression of NF-kappaB p65, COX-2, iNOS, TNF-alpha, IL-1beta, and IL-6 in the cells, suggesting that long-term MC-LR exposure at low concentration can induce inflammatory reaction to HepG2 cells, which might account for MC-induced human hepatitis. Methylcholanthrene 36-38 interleukin 6 Homo sapiens 154-158 29245047-0 2018 Polyriboinosinic-polyribocytidylic acid facilitates interleukin-6, and interleukin-8 secretion in human dermal fibroblasts via the JAK/STAT3 and p38 MAPK signal transduction pathways. Poly I-C 0-39 interleukin 6 Homo sapiens 52-65 29245047-3 2018 Here, we found that polyI:C enhances IL-6 and IL-8 mRNA expression and induces of IL-6 and IL-8 production in a concentration-dependent and time-dependent manner in HDFs. Poly I-C 20-27 interleukin 6 Homo sapiens 37-41 29245047-3 2018 Here, we found that polyI:C enhances IL-6 and IL-8 mRNA expression and induces of IL-6 and IL-8 production in a concentration-dependent and time-dependent manner in HDFs. Poly I-C 20-27 interleukin 6 Homo sapiens 82-86 29245047-5 2018 Moreover, pretreatment with AG490, a Janus kinase (JAK) inhibitor, inhibited polyI:C-induced STAT3 phosphorylation and subsequent IL-6 and IL-8 release. Poly I-C 77-84 interleukin 6 Homo sapiens 130-134 29061842-8 2018 Inhibition of p38 with SB203580 prevented IL-6 production, without altering permeability. SB 203580 23-31 interleukin 6 Homo sapiens 42-46 30215534-8 2018 Suppression of LPS-induced Il6 and Ccl2 genes by CpdA in macrophages is hampered upon Sqstm1 silencing, confirming that SQSTM1 is essential for the anti-inflammatory capacity of CpdA, at least in this cell type. CPDA 49-53 interleukin 6 Homo sapiens 27-30 30153667-9 2018 The mRNA expression of TNF-alpha, IL-1beta and IL-6 in PVECs was detected by quantitative real-time polymerase chain reaction (qRT-PCR), HO-1 expression and enzymatic activity in PVECs and the influence of zinc protoporphyrin (ZnPP) or HO-1 small interfering RNA on the above inflammatory and oxidative stress markers were evaluated. zinc protoporphyrin 206-225 interleukin 6 Homo sapiens 47-51 30153667-9 2018 The mRNA expression of TNF-alpha, IL-1beta and IL-6 in PVECs was detected by quantitative real-time polymerase chain reaction (qRT-PCR), HO-1 expression and enzymatic activity in PVECs and the influence of zinc protoporphyrin (ZnPP) or HO-1 small interfering RNA on the above inflammatory and oxidative stress markers were evaluated. zinc protoporphyrin 227-231 interleukin 6 Homo sapiens 47-51 30303416-13 2018 These findings suggest that the observed rise in IL-6 during hyperthermia is mediated, at least in part, by plasma adrenaline. Epinephrine 115-125 interleukin 6 Homo sapiens 49-53 29121681-5 2018 We found inflammatory behavior for the CTBFR group with a significant difference in serum concentration of C-reactive protein between pre- and post-moment (0.96+-0.37 to 1.71+-1.45, p=0.049), with no difference between groups, and a time effect in interleukin-6 (pre=0.86+-0.43; post=1.02+-0.46, p=0.016). ctbfr 39-44 interleukin 6 Homo sapiens 248-261 29028602-6 2017 Co-exposure of A549 cells or A549 epithelium model to DPPC and ZnO NPs induced a higher release of lactate dehydrogenase (LDH) and interleukin-6 (IL-6) compared with the exposure of ZnO NPs alone. 1,2-Dipalmitoylphosphatidylcholine 54-58 interleukin 6 Homo sapiens 131-144 29028602-6 2017 Co-exposure of A549 cells or A549 epithelium model to DPPC and ZnO NPs induced a higher release of lactate dehydrogenase (LDH) and interleukin-6 (IL-6) compared with the exposure of ZnO NPs alone. 1,2-Dipalmitoylphosphatidylcholine 54-58 interleukin 6 Homo sapiens 146-150 28634059-3 2017 Moreover, PPPF is able to suppress both constitutive and IL-6-induced phosphorylation of STAT3 (on Tyr705) and subsequent nuclear translocation in cancer cells. pppf 10-14 interleukin 6 Homo sapiens 57-61 28382703-8 2017 The therapeutic effect of GF9 was accompanied by a reduction in the plasma levels of macrophage colony-stimulating factor and pro-inflammatory cytokines such as tumour necrosis factor-alpha, interleukin (IL)-1 and IL-6. gf9 26-29 interleukin 6 Homo sapiens 214-218 28666365-4 2017 Chronic 30 mg/l CdCl2 treatment elevated murine blood Cd level comparable to that of low dose Cd-exposed humans, had no effect on blood total and differential leukocyte counts, but reduced neutrophil infiltration, chemokines (CXCL1 and CXCL2), and proinflammatory cytokines (TNFalpha, IL-1beta, and IL-6) expression in wounded tissue at early stage after injury. Cadmium Chloride 16-21 interleukin 6 Homo sapiens 299-303 28946703-0 2017 Acyclic Triterpenoids from Alpinia katsumadai Inhibit IL-6-Induced STAT3 Activation. triterpenoids 8-21 interleukin 6 Homo sapiens 54-58 28891967-7 2017 Ginsenoside Rg3 (10 mug/mL) effectively suppressed the expressions of IL-6 and IL-8, which is associated with regulations of NF-kappaB and p38MAPK activation. Ginsenosides 0-11 interleukin 6 Homo sapiens 70-74 28692879-3 2017 The results showed that pitavastatin inhibited the expression of inflammatory mediators IL-6 and IL-8. pitavastatin 24-36 interleukin 6 Homo sapiens 88-92 28692879-6 2017 These findings suggest that the mechanism underlying the inhibitory effects of pitavastatin on IL-1beta-induced IL-6 and IL-8 release might be mediated by the suppression of mitogen-activated protein kinase (MAPK), Akt, and nuclear factor-kappaB (NF-kappaB) signaling pathways. pitavastatin 79-91 interleukin 6 Homo sapiens 112-116 28466979-7 2017 The production of IL-6 and MCP-1 cytokines was also dependent on the structure of PTFE that the macrophages interacted with, but in a time-dependent manner. Polytetrafluoroethylene 82-86 interleukin 6 Homo sapiens 18-22 28457017-8 2017 CONCLUSION: Signatures of anthocyanin metabolites following dietary consumption reduce VCAM-1 and IL-6 production, providing evidence of physiologically relevant biological activity. Anthocyanins 26-37 interleukin 6 Homo sapiens 98-102 28351806-13 2017 In addition, IL-6 was also positively associated with As, Cl and Pe in elderly. Arsenic 54-56 interleukin 6 Homo sapiens 13-17 28233119-8 2017 Among participants without CAD history who underwent CCTA, patients with high level of IL-6 had increased burden of atherosclerosis and higher MACE risk compared to participants of low level of IL-6. ccta 53-57 interleukin 6 Homo sapiens 87-91 28693194-9 2017 Therefore, the combination of warfarin and lenalidomide may cause a pharmacodynamic interaction, more likely by inhibiting the production of interleukin-6. Lenalidomide 43-55 interleukin 6 Homo sapiens 141-154 28427199-10 2017 Treatment of A549 with a combination of polyI:C and anti-IL6 antibody significantly decreased IL6 production, and enhanced polyI:C-mediated killing and suppression of oncogenicity and metastasis. Poly I-C 40-47 interleukin 6 Homo sapiens 94-97 28427199-10 2017 Treatment of A549 with a combination of polyI:C and anti-IL6 antibody significantly decreased IL6 production, and enhanced polyI:C-mediated killing and suppression of oncogenicity and metastasis. Poly I-C 123-130 interleukin 6 Homo sapiens 57-60 28427199-13 2017 The combinatorial treatment with polyI:C and anti-IL6 enhanced polyI:C-mediated anticancer activities through IL6/JAK2/STAT3 signalling, and apoptosis via TLR3-mediated caspase 3/8 pathway. Poly I-C 33-40 interleukin 6 Homo sapiens 110-113 28814929-5 2017 The cell viability of HSF and A549 cells was identified by the MTT assay and trypan blue exclusion. monooxyethylene trimethylolpropane tristearate 63-66 interleukin 6 Homo sapiens 22-25 28814929-5 2017 The cell viability of HSF and A549 cells was identified by the MTT assay and trypan blue exclusion. Trypan Blue 77-88 interleukin 6 Homo sapiens 22-25 28431555-11 2017 After 40 h exposure, EDTMP coated MOx show significant decreases of neutrophil counts, lactate dehydrogenase (LDH) release, MCP-1, LIX and IL-6 in bronchoalveolar lavage fluid (BALF), compared to uncoated particles. MOX 34-37 interleukin 6 Homo sapiens 139-143 28276471-4 2017 Here, we demonstrate that the IL-6R is a shedding substrate of soluble meprin alpha and membrane bound meprin beta, resulting in bioactive sIL-6R that is capable of inducing IL-6 trans-signaling. sil-6r 139-145 interleukin 6 Homo sapiens 30-34 27669541-8 2017 Sucrose activated autophagy blocked IL-1beta-induced apoptosis and mRNA expression of MMP-13, COX-2, and IL-6 in human OA chondrocytes. Sucrose 0-7 interleukin 6 Homo sapiens 105-109 28272227-9 2017 After surgery, the levels of interleukin-6 (IL-6), tumor necrosis factor alpha, and thromboxane B2 decreased by 23.5%, 9.1%, and 30.2%, respectively, in the xenon group, but increased by 10.8%, 26.2%, and 26.4%, respectively, in the control group. Xenon 157-162 interleukin 6 Homo sapiens 29-42 28272227-9 2017 After surgery, the levels of interleukin-6 (IL-6), tumor necrosis factor alpha, and thromboxane B2 decreased by 23.5%, 9.1%, and 30.2%, respectively, in the xenon group, but increased by 10.8%, 26.2%, and 26.4%, respectively, in the control group. Xenon 157-162 interleukin 6 Homo sapiens 44-48 27665119-6 2017 The demethylation by AZA increased the expression of IL-6 and TNF-alpha in LPS-stimulated broiler PBMC. Decitabine 21-24 interleukin 6 Homo sapiens 53-57 28035387-12 2017 In combination with IL-6 or IL-8, prednisone, ibuprofen and betamethasone significantly reduced the levels of collagen I, MMP-1 and MMP-13, and inactivated NF-kappaB and STAT3 pathways. Betamethasone 60-73 interleukin 6 Homo sapiens 20-24 28035387-13 2017 In conclusion, prednisone, ibuprofen and betamethasone may prevent OA by suppressing the expression of IL-6 and IL-8, subsequently inactivating NF-kappaB and STAT3 pathways, and ultimately, leading to decreased levels of collagen I, MMP-1, and MMP-13. Betamethasone 41-54 interleukin 6 Homo sapiens 103-107 28007550-9 2017 Transient changes in urothelial ATP and PGE2 release were observed, with significant increase in release of interleukin-6, interleukin-8 and interleukin-1beta from urothelial cells treated with gemcitabine. gemcitabine 194-205 interleukin 6 Homo sapiens 108-121 28009871-10 2017 IL-1beta, IL-6 and TNF-alpha protein expressions were also reduced in TNF-alpha-treated CCD-18Co cells by CP anthocyanins at 20.0 mug ml-1 GAE. Anthocyanins 109-121 interleukin 6 Homo sapiens 10-14 27689692-5 2017 These results demonstrate that Schizandrin B can regulate the function of decreasing intracellular SOD"s activity and increasing the expression level of MDA in HaCaT cells result from the guidance of UVB, and it markedly reduced the production of inflammatory factors such as Cox-2, IL-6 or IL-18, decreased the expression level of MMP-1, and interdicted degradation process of collagens in UVB-radiated cells. schizandrin B 31-44 interleukin 6 Homo sapiens 283-287 27863298-10 2017 We found that butein significantly inhibited the IL-1beta-induced production of NO and PGE2, expression of COX-2, iNOS, TNF-alpha, IL-6 and MMP-13, degradation of COL-2 and SOX-9 at mRNA and protein levels as well as MMP-1, MMP-3, ADAMTS-4 and ADAMTS-5 gene expression. butein 14-20 interleukin 6 Homo sapiens 131-135 26597827-7 2017 Prednisolone treatment improved the hypercalcemia and decreased the levels of 1,25(OH)2D and IL-6. Prednisolone 0-12 interleukin 6 Homo sapiens 93-97 28171867-15 2017 CONCLUSION: The IL-6 (-174) GC genotype is associated with a smaller C/D ratio, larger RA, and thicker RNFL compared with IL-6 (-174) GG in NTG patients. Radium 87-89 interleukin 6 Homo sapiens 16-20 28805765-15 2017 aMCI was characterized by the significant increase in the activity/level of alpha1-PI and IL-6 (p<0.0001; p<0.01). amci 0-4 interleukin 6 Homo sapiens 90-94 27639126-10 2016 ROS scavenger N-acetylcysteine (NAC) and NF-kappaB inhibitor PDTC showed similar effect on PA-induced secretion of TNF-alpha, IL-6, and expression of ICAM-1. Palmitic Acid 91-93 interleukin 6 Homo sapiens 126-130 27655706-9 2016 Blood levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-1beta increased in gemcitabine alone group, however, it was decreased in gemcitabine with GV1001 group. gemcitabine 96-107 interleukin 6 Homo sapiens 51-69 27590705-0 2016 6"-O-Caffeoyldihydrosyringin isolated from Aster glehni suppresses lipopolysaccharide-induced iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 expression via NF-kappaB and AP-1 inactivation in RAW 264.7 macrophages. 6"-o-caffeoyldihydrosyringin 0-28 interleukin 6 Homo sapiens 131-135 27281236-6 2016 The results showed that OEA suppressed the expression of interleukin-6, interleukin-8, vascular adhesion molecule-1, and intercellular adhesion molecule-1 in a dose-dependent manner. N-oleoylethanolamine 24-27 interleukin 6 Homo sapiens 57-70 27165055-8 2016 Keratinocytes treated with erlotinib in vitro showed a significant down-modulation of hyaluronan synthases (HAS2 and HAS3), whereas senescence-associated genes (p21, p53, IL-6, maspin) were upregulated, along with a G1 cell cycle arrest and stronger SA beta-Gal activity. Erlotinib Hydrochloride 27-36 interleukin 6 Homo sapiens 171-175 27687804-9 2016 In vitro, monocytes responding to IL-6 by STAT3 phosphorylation were prevented to respond in gemcitabine medium. gemcitabine 93-104 interleukin 6 Homo sapiens 34-38 27457805-7 2016 RESULTS: PA elevated not only phosphorylation of JNK and IKKalpha/beta, but also the expression of IL-6 in HUVECs. Palmitic Acid 9-11 interleukin 6 Homo sapiens 99-103 27488030-7 2016 Moreover, 10 and 20 muM DCVC increased mRNA expression and release of interleukin-6 (IL-6) after 24-h exposure, and these responses were inhibited by the cysteine conjugate beta-lyase inhibitor aminooxyacetic acid and by treatments with antioxidants (alpha-tocopherol and deferoxamine), suggesting that DCVC-stimulated IL-6 release in HTR-8/SVneo cells is dependent on beta-lyase metabolic activation and increased generation of ROS. Aminooxyacetic Acid 194-213 interleukin 6 Homo sapiens 70-83 27488030-7 2016 Moreover, 10 and 20 muM DCVC increased mRNA expression and release of interleukin-6 (IL-6) after 24-h exposure, and these responses were inhibited by the cysteine conjugate beta-lyase inhibitor aminooxyacetic acid and by treatments with antioxidants (alpha-tocopherol and deferoxamine), suggesting that DCVC-stimulated IL-6 release in HTR-8/SVneo cells is dependent on beta-lyase metabolic activation and increased generation of ROS. Aminooxyacetic Acid 194-213 interleukin 6 Homo sapiens 85-89 27488030-7 2016 Moreover, 10 and 20 muM DCVC increased mRNA expression and release of interleukin-6 (IL-6) after 24-h exposure, and these responses were inhibited by the cysteine conjugate beta-lyase inhibitor aminooxyacetic acid and by treatments with antioxidants (alpha-tocopherol and deferoxamine), suggesting that DCVC-stimulated IL-6 release in HTR-8/SVneo cells is dependent on beta-lyase metabolic activation and increased generation of ROS. Aminooxyacetic Acid 194-213 interleukin 6 Homo sapiens 319-323 27394658-6 2016 p38 and ERK1/2 MAPKs were involved in this effect, as indicated by the Cry1Ac-induced upregulation of CD80 and IL-6 and TNF-alpha abrogation by the p38 MAPK inhibitor SB203580. SB 203580 167-175 interleukin 6 Homo sapiens 111-115 27571064-12 2016 p38 MAPK inhibitor SB239063 significantly attenuated IL-6 and IL-8 release the most (p <= 0.05). SB 239063 19-27 interleukin 6 Homo sapiens 53-57 27038016-11 2016 Moreover, sodium nitrite significantly elevated TNF-alpha, IL-1beta, IL-6, caspase-3 and reduced Nrf2. Sodium Nitrite 10-24 interleukin 6 Homo sapiens 69-73 26986049-3 2016 Methods IL-6 methylation levels of 582 cases and 673 controls were measured using the bisulfite pyrosequencing technology. hydrogen sulfite 86-95 interleukin 6 Homo sapiens 8-12 27210890-7 2016 KEY FINDINGS: RA significantly inhibited poly(I:C)-induced expression of inflammatory cytokines including IL-1beta, IL-6, IL-8, CCL20, and TNF-alpha, and downregulated NF-kappaB signaling pathway in human keratinocytes. Poly I-C 41-50 interleukin 6 Homo sapiens 116-120 27072015-6 2016 Shikonin prevented IL-1beta- or tumor necrosis factor (TNF)-alpha-mediated IL-6, IL-8, and CCL20 production in HPDLC. shikonin 0-8 interleukin 6 Homo sapiens 75-79 27140710-6 2016 Tumor necrosis factor alpha, IL-6 and IL-8 levels on the fourth day after treatment showed significant decrease in the somatostatin + ulinastatin, the somatostatin + gabexate and the somatostatin + ulinastatin + gabexate subgroups compared with the somatostatin subgroup. Gabexate 166-174 interleukin 6 Homo sapiens 29-33 26947457-5 2016 The new compound murrayakonine A (), O-methylmurrayamine A () and murrayanine () were proven to be the most active, efficiently inhibiting TNF-alpha and IL-6 release in a dose-dependent manner and showing decreased LPS induced TNF-alpha and IL-6 production in human PBMCs [corrected]. O-methylmurrayamine A 37-58 interleukin 6 Homo sapiens 153-157 26915800-7 2016 We also found that the effects of APS on upregulating hepcidin and IL-6 expressions could be antagonized by pretreatment with SB203580, an inhibitor of p38 MAPK signaling. SB 203580 126-134 interleukin 6 Homo sapiens 67-71 26700310-5 2016 Culture of U266, RPMI8226 and CD138(+) cells with exogenous IL-6 in vitro induced high HO-1 expression levels and allowed them to resist lenalidomide. Lenalidomide 137-149 interleukin 6 Homo sapiens 60-64 26700310-10 2016 Therefore, we postulated that IL-6 in the bone marrow microenvironment of MM patients stimulated high HO-1 expression in MM cells and their resistance to lenalidomide. Lenalidomide 154-166 interleukin 6 Homo sapiens 30-34 26460847-11 2016 Furthermore, quantitative PCR data also showed that the interleukin-6 expression was highly induced by boanmycin to six-fold in OBs. bleomycin A6 103-112 interleukin 6 Homo sapiens 56-69 26673543-4 2016 The results showed that the PPAR-gamma agonist pioglitazone decreased the expression of NF-kappaB p65 transcription target genes (e.g., IL-6, IL-1beta, and TNF-alpha) and inhibited histological injury and inflammatory cells infiltration in cisplatin nephrotoxicity. Pioglitazone 47-59 interleukin 6 Homo sapiens 136-140 26673543-8 2016 Interestingly, the reduction of IL-6, TNF-alpha and IL-1beta, the inhibition of histological injury and the inflammatory cells infiltration following pioglitazone treatment in cisplatin nephrotoxicity were attenuated after treatment with the PPAR-gamma antagonist GW9662. Pioglitazone 150-162 interleukin 6 Homo sapiens 32-36 27279834-8 2016 Administration of CPJ caused significant reduction in serum interleukin-6 (IL-6) (P < 0.05), but tumor necrosis factor-alpha (TNF-alpha) and high-sensitivity C-reactive protein (hs-CRP) remained unchanged during the study. cpj 18-21 interleukin 6 Homo sapiens 60-73 27279834-8 2016 Administration of CPJ caused significant reduction in serum interleukin-6 (IL-6) (P < 0.05), but tumor necrosis factor-alpha (TNF-alpha) and high-sensitivity C-reactive protein (hs-CRP) remained unchanged during the study. cpj 18-21 interleukin 6 Homo sapiens 75-79 26784906-11 2016 Further, variable selection using random forest backward elimination revealed six serum biosignatures including IL-12, IL-4, IL-6, IL-10, IL-8 and TNF-beta as optimal for classifying the LNTB status of an individual. lntb 187-191 interleukin 6 Homo sapiens 125-129 26933666-1 2016 Early, presymptomatic intervention with oseltamivir (corresponding to the onset of a published host-based genomic signature of influenza infection) resulted in decreased overall influenza symptoms (aggregate symptom scores of 23.5 vs 46.3), more rapid resolution of clinical disease (20 hours earlier), reduced viral shedding (total median tissue culture infectious dose [TCID50] 7.4 vs 9.7), and significantly reduced expression of several inflammatory cytokines (interferon-gamma, tumor necrosis factor-alpha, interleukin-6, and others). Oseltamivir 40-51 interleukin 6 Homo sapiens 512-525 26819847-10 2016 A significant positive association was observed between maternal CES-D scores and IL-6 mRNA expression in the children with asthma. Cerium 65-68 interleukin 6 Homo sapiens 82-86 26501163-6 2016 We demonstrated that: (i) the inflammatory marker IL-6 is upregulated in labored placentas; (ii) IL-6 content inversely correlates with labor duration; (iii) ceramide content and expression of serine palmitoyl transferase (SPT, rate limiting enzyme for de novo ceramide synthesis) are increased in labored placentas; (iv) the expression of SPT directly correlates with inflammation and inversely with labor duration. Ceramides 158-166 interleukin 6 Homo sapiens 50-54 26501163-6 2016 We demonstrated that: (i) the inflammatory marker IL-6 is upregulated in labored placentas; (ii) IL-6 content inversely correlates with labor duration; (iii) ceramide content and expression of serine palmitoyl transferase (SPT, rate limiting enzyme for de novo ceramide synthesis) are increased in labored placentas; (iv) the expression of SPT directly correlates with inflammation and inversely with labor duration. Ceramides 261-269 interleukin 6 Homo sapiens 50-54 26536614-1 2016 OBJECTIVE: To evaluate the effect of N-benzyl-4-bromobenzamide (NBBA) on lipopolysaccharide (LPS)-induced IL-6 and prostaglandin E2 (PGE2) production in human gingival fibroblasts (HGFs). NBBA 64-68 interleukin 6 Homo sapiens 106-110 26536614-13 2016 CONCLUSIONS: NBBA exhibited an inhibitory effect on the production of IL-6 and PGE2 in LPS-induced HGFs. NBBA 13-17 interleukin 6 Homo sapiens 70-74 27194825-2 2016 We used 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a neurotoxin that induces Parkinson disease, to evaluate the change of midbrain structure and the behavior of the anti-inflammatory factor e-cadherin, interleukin-6, tyrosine hydroxylase, phosphatase and tensin homolog, and caveolin-1. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 54-58 interleukin 6 Homo sapiens 212-225 26573554-7 2016 In human mast cells, sesamin reduced the stimulatory effects of phorbol 12-myristate 13-acetate and calcium ionophore A23187 on the production and secretion of pro-inflammatory cytokines, including tumor necrosis factor-alpha and interleukin-6. sesamin 21-28 interleukin 6 Homo sapiens 230-243 26758677-11 2016 However, the patients in the MC group had higher IL-6 mean values six hours post-operatively (POP2), the mean IL-6 values being 27.6 pg/ml in the MC group versus 14.8 pg/ml in the LC group (p = 0.037). Methylcholanthrene 29-31 interleukin 6 Homo sapiens 49-53 26758677-11 2016 However, the patients in the MC group had higher IL-6 mean values six hours post-operatively (POP2), the mean IL-6 values being 27.6 pg/ml in the MC group versus 14.8 pg/ml in the LC group (p = 0.037). Methylcholanthrene 29-31 interleukin 6 Homo sapiens 110-114 26758677-12 2016 In addition, the patients in the MC group had higher elevation of the IL-6 mean values post-operatively, the mean pre-/post-operative IL-6 values being 4.1/27.6 pg/ml in the MC group versus 3.8/14.8 pg/ml in the LC group (p = 0.04). Methylcholanthrene 33-35 interleukin 6 Homo sapiens 70-74 26758677-12 2016 In addition, the patients in the MC group had higher elevation of the IL-6 mean values post-operatively, the mean pre-/post-operative IL-6 values being 4.1/27.6 pg/ml in the MC group versus 3.8/14.8 pg/ml in the LC group (p = 0.04). Methylcholanthrene 33-35 interleukin 6 Homo sapiens 134-138 26758677-12 2016 In addition, the patients in the MC group had higher elevation of the IL-6 mean values post-operatively, the mean pre-/post-operative IL-6 values being 4.1/27.6 pg/ml in the MC group versus 3.8/14.8 pg/ml in the LC group (p = 0.04). Methylcholanthrene 174-176 interleukin 6 Homo sapiens 134-138 26758677-15 2016 A new finding with possible clinical relevance in the present work is higher relative elevation of the IL-1ra and IL-6 mean values post-operatively in the MC group. Methylcholanthrene 155-157 interleukin 6 Homo sapiens 114-118 26668716-7 2015 Stimulation with Poly(I:C) resulted in a significant increased secretion of IL-4, IL-6, RANTES, IP-10, MIP-1beta, VEGF, FGF, IL-1RA, IL-2R and G-CSF. Poly I-C 17-25 interleukin 6 Homo sapiens 82-86 26668716-8 2015 Stimulation with PGN only resulted in significant increased production of IL-6, VEGF and IL-1RA. pgn 17-20 interleukin 6 Homo sapiens 74-78 26541096-7 2015 Additionally, butyrate and propionate inhibited the expression of lipopolysaccharide (LPS)-induced cytokines such as IL-6 and IL-12p40 showing a strong anti-inflammatory effect. Butyrates 14-22 interleukin 6 Homo sapiens 117-121 26614998-10 2015 The propofol could inhibit the expression of IL-6, IL-8 and TNF-alpha caused by LPS. Propofol 4-12 interleukin 6 Homo sapiens 45-49 26614998-11 2015 After the intervention treatment of 50 mug/mL propofol, the concentration of IL-6, IL-8 and TNF-alpha was significantly decreased (P < 0.01). Propofol 46-54 interleukin 6 Homo sapiens 77-81 26352276-6 2015 ELISA demonstrated that pitavastatin inhibited mRNA and protein expression of interleukin (IL)-1beta, IL-6 and tumor necrosis factor-alpha. pitavastatin 24-36 interleukin 6 Homo sapiens 102-138 26467531-6 2015 RESULTS: Xenon enhanced the postoperative increase of IL-6 compared to sevoflurane (Xenon: 90.7 versus sevoflurane: 33.7 pg/ml; p = 0.035) and attenuated the increase of IL-10 (Xenon: 127.9 versus sevoflurane: 548.3 pg/ml; p = 0.028). Xenon 9-14 interleukin 6 Homo sapiens 54-58 26622533-5 2015 We tested the dose-response association between EESB, IL-6-induced proliferaion and apoptosis using an MTT assay, colony formation and flow cytometry analysis in vitro. monooxyethylene trimethylolpropane tristearate 103-106 interleukin 6 Homo sapiens 54-58 26105582-8 2015 Fenofibrate, alone and in combination with pioglitazone, significantly decreased triacylglycerol, hs-CRP, IL-6, fetuin A and increased sirtuin 1 levels (P<0.001) which suggests that it can be used to delay the complications of obesity and T2DM. Pioglitazone 43-55 interleukin 6 Homo sapiens 106-110 25214388-9 2015 After adjustment for age, education level, number of years of completed education, illness duration, total PANSS score, depression severity and chlorpromazine equivalent, there was still a positive association between IL-6 and hsCRP levels and worse cognitive performance. Chlorpromazine 144-158 interleukin 6 Homo sapiens 218-222 25815690-5 2015 Pic increased the expression of HO-1 via nuclear factor erythroid-2-related factor-2 activation in the HUVECs, and decreased the PA-induced secretions of interleukin-6 and tumor necrosis factor-alpha, and the formation of reactive oxygen species ROS via inhibition of NF-kappaB activation. Palmitic Acid 129-131 interleukin 6 Homo sapiens 154-199 25777483-10 2015 Treatment with astaxanthin or withaferin A significantly reduced the increased levels of interleukin-1alpha, interleukin-6/8, granulocyte macrophage stimulatory factor and endothelin-1. astaxanthine 15-26 interleukin 6 Homo sapiens 109-124 25907222-7 2015 Furthermore nitric oxide synthetase activity in endothelial cells that had been treated with IL-6 was measured using l-NAME. NG-Nitroarginine Methyl Ester 117-123 interleukin 6 Homo sapiens 93-97 25895106-0 2015 Isolation and Characterization of Dammarane-Type Saponins from Gynostemma pentaphyllum and Their Inhibitory Effects on IL-6-Induced STAT3 Activation. Saponins 49-57 interleukin 6 Homo sapiens 119-123 25849219-5 2015 Delivering 12-base-long pyrrolidinyl peptide nucleic acids with d-prolyl-(1S,2S)-2-aminocyclopentanecarboxylic acid backbone (acpcPNA) complementary to the antisense strand of the NF-kappaB binding site in the promoter region of the Il6 gene into the macrophage cell line, RAW 264.7, by our particles resulted in an obvious accumulation of the acpcPNAs in the nucleus and decreased Il6 mRNA and IL-6 protein levels upon stimulation. 12-base-long pyrrolidinyl peptide 11-44 interleukin 6 Homo sapiens 233-236 25849219-5 2015 Delivering 12-base-long pyrrolidinyl peptide nucleic acids with d-prolyl-(1S,2S)-2-aminocyclopentanecarboxylic acid backbone (acpcPNA) complementary to the antisense strand of the NF-kappaB binding site in the promoter region of the Il6 gene into the macrophage cell line, RAW 264.7, by our particles resulted in an obvious accumulation of the acpcPNAs in the nucleus and decreased Il6 mRNA and IL-6 protein levels upon stimulation. 12-base-long pyrrolidinyl peptide 11-44 interleukin 6 Homo sapiens 382-385 25849219-5 2015 Delivering 12-base-long pyrrolidinyl peptide nucleic acids with d-prolyl-(1S,2S)-2-aminocyclopentanecarboxylic acid backbone (acpcPNA) complementary to the antisense strand of the NF-kappaB binding site in the promoter region of the Il6 gene into the macrophage cell line, RAW 264.7, by our particles resulted in an obvious accumulation of the acpcPNAs in the nucleus and decreased Il6 mRNA and IL-6 protein levels upon stimulation. 12-base-long pyrrolidinyl peptide 11-44 interleukin 6 Homo sapiens 395-399 26191223-6 2015 PE significantly inhibited poly (I:C)-induced expression of crucial psoriatic cytokines, such as IL-6, IL-8, CCL20 and TNF-alpha, via down-regulation of NF-kappaB signaling pathway in human keratinocytes. Poly I-C 27-37 interleukin 6 Homo sapiens 97-101 25794236-6 2015 MVIC (P < 0.05) did not decline in the MC group (vs. PLA) across the 72-h post-trial period and economy (P < 0.05) was improved in the MC group at 24 h. IL-6 (P < 0.001) and hsCRP (P < 0.05) responses to the trial were attenuated with MC (vs. PLA). Methylcholanthrene 141-143 interleukin 6 Homo sapiens 159-163 25794236-6 2015 MVIC (P < 0.05) did not decline in the MC group (vs. PLA) across the 72-h post-trial period and economy (P < 0.05) was improved in the MC group at 24 h. IL-6 (P < 0.001) and hsCRP (P < 0.05) responses to the trial were attenuated with MC (vs. PLA). Methylcholanthrene 141-143 interleukin 6 Homo sapiens 159-163 25532794-8 2015 Poly(I:C) induced activation of TLR-2 contributes to stronger cell responses to a TLR-2 agonist and regulation of these synergistic responses may take place at the mRNA level of IL-6 and IL-8. Poly I-C 0-8 interleukin 6 Homo sapiens 178-182 25888119-10 2015 In a univariate analysis IL6 and IL8 levels were associated with SAA>6.4 mg/l (OR=1.74 and 1.46; 95% CI=1.00-3.03 and 1.06-2.01; p=0.051 and 0.02 respectively) and hsCRP>3 mg/l in (OR=2.00 and 1.37; 95% CI=1.09-3.69 and 1.02-1.85; p=0.026 and 0.039 respectively). hscrp 167-172 interleukin 6 Homo sapiens 25-28 25609203-7 2015 rhSDF-1alpha protected Panc-1 cells from GEM-induced apoptosis, and the protective effect was significantly reduced by blocking IL-6 using a neutralizing antibody. gemcitabine 41-44 interleukin 6 Homo sapiens 128-132 25849622-11 2015 IL-6 expression was more sensitive to inhibition of p38 (using SB203580) and was affected by Stattic in response to IL-17A/OSM stimulation. SB 203580 63-71 interleukin 6 Homo sapiens 0-4 25498116-3 2015 In this communication, we report an atomic force microscopy (AFM) analysis evidencing a strong relationship between immunological activities of mouse monoclonal anti-human interleukin-2 (IL-2) and 6 (IL-6) antibodies, thickness and roughness of the IgG monolayer adsorbed onto h-SAMs, and surface concentration of IgG molecules. h-sams 277-283 interleukin 6 Homo sapiens 200-204 25737017-8 2015 Decreases in inflammatory markers such as IL-6, TNF-alpha, and sVCAM-1 were significantly greater in the pioglitazone than the control group during the follow-up. Pioglitazone 105-117 interleukin 6 Homo sapiens 42-46 25198400-0 2015 Taurine inhibits interleukin-6 expression and release induced by ultraviolet B exposure to human retinal pigment epithelium cells. Taurine 0-7 interleukin 6 Homo sapiens 17-30 25198400-7 2015 The accumulation of IL-6 in UVB-exposed human retinal pigment epithelial cells supernatant was much slower when the cells were preincubated with taurine. Taurine 145-152 interleukin 6 Homo sapiens 20-24 25198400-8 2015 Moreover, taurine suppressed IL-6 concentration in aqueous humour. Taurine 10-17 interleukin 6 Homo sapiens 29-33 25198400-9 2015 CONCLUSION: The effect of compatible osmolyte taurine on IL-6 expression and release may play an important role in cell resistance and adaption to UVB exposure. Taurine 46-53 interleukin 6 Homo sapiens 57-61 25549668-5 2015 In the neuronally derived A1A1 cell line, which expresses both IL-6 and 5-HT2A receptors, we found that IL-6 attenuates inositol phosphate (IP) accumulation in response to the 5-HT2 agonist, 2,5-dimethoxy-4-iodoamphetamine (DOI), suggesting that IL-6 can regulate 5-HT2A receptor function. 4-iodo-2,5-dimethoxyphenylisopropylamine 191-222 interleukin 6 Homo sapiens 104-108 25474105-8 2014 Ramipril reduces mRNA expression of multiple pro-inflammatory cytokines such as IL-1beta, IL-6, IL-8, TNF -alpha, Interferon-[Formula: see text], and MCP-1, as well as aortic wall IL-8 and MCP-1 (P = 0.017 and 0.008, respectively) protein content. Ramipril 0-8 interleukin 6 Homo sapiens 90-94 25256070-3 2014 This study investigates the effects of ramipril on the oxidoinflammatory cytokines (IL-6, IL-8, TNF-alpha) and TnT (myocardial injury marker) and their alteration in association with ACE I/D gene polymorphisms. Ramipril 39-47 interleukin 6 Homo sapiens 84-88 24690561-0 2014 A new signal amplification strategy of photoelectrochemical immunoassay for highly sensitive interleukin-6 detection based on TiO2/CdS/CdSe dual co-sensitized structure. cdse 135-139 interleukin 6 Homo sapiens 93-106 24690561-1 2014 Dual co-sensitized structure of TiO2/CdS/CdSe was designed to develop a novel photoelectrochemical immunoassay for highly sensitive detection of human interleukin-6 (IL-6). cdse 41-45 interleukin 6 Homo sapiens 151-164 24690561-1 2014 Dual co-sensitized structure of TiO2/CdS/CdSe was designed to develop a novel photoelectrochemical immunoassay for highly sensitive detection of human interleukin-6 (IL-6). cdse 41-45 interleukin 6 Homo sapiens 166-170 24690561-7 2014 Accordingly, upon the co-sensitization strategy, a novel immunoassay based on the competitive binding of anti-IL-6 antibody with IL-6 antigen and IL-6-CdSe bioconjugate was developed, and it exhibited a wide linear range from 1.0 pg/mL to 100 ng/mL with a low detection limit of 0.38 pg/mL for IL-6 detection. cdse 151-155 interleukin 6 Homo sapiens 110-114 25128276-7 2014 ALO attenuated CCI induced up-regulation of expressions of NF-kappaB, TNF-alpha, IL-6, IL-1beta at the dose of 80mg/kg (i.p.). aloperine 0-3 interleukin 6 Homo sapiens 81-85 24951586-3 2014 In this work, we sought to define the role of ASM in IL-6 production because our previous work showed that a parallel pathway of ceramide metabolism, acid beta-glucosidase 1, negatively regulates IL-6. Ceramides 129-137 interleukin 6 Homo sapiens 53-57 24951586-3 2014 In this work, we sought to define the role of ASM in IL-6 production because our previous work showed that a parallel pathway of ceramide metabolism, acid beta-glucosidase 1, negatively regulates IL-6. Ceramides 129-137 interleukin 6 Homo sapiens 196-200 24854955-9 2014 The mRNA for interleukin-6 and tumor necrosis factor-alpha was higher with AEA but lower with DHA and docosahexaenoyl ethanolamide (DHEA), supporting previous findings that the EC AEA supports activation of the COX system. Docosahexaenoyl Ethanolamide 102-130 interleukin 6 Homo sapiens 13-58 24891006-12 2014 The post-race fall in plasma TNF-alpha in the CSCI group could be related to the inhibitory effect of rising IL-6 in the presence of normal monocyte count and stable adrenaline level. Epinephrine 166-176 interleukin 6 Homo sapiens 109-113 24830721-4 2014 We found that sustained overexpression of the pro-inflammatory IL6 promoted arsenic-induced cell transformation by inhibiting autophagy. Arsenic 76-83 interleukin 6 Homo sapiens 63-66 24966150-2 2014 We hypothesized that patients who received propofol-epidural anaesthesia (PEA) would exhibit decreases in VEGF-C, TGF-beta, and IL-6 and an increase in IL-10 compared with patients who received general anaesthesia (GA). Propofol 43-51 interleukin 6 Homo sapiens 128-132 24985027-8 2014 beta-cryptoxanthin (P=0.04) and lycopene (P=0.02) inversely correlated with CSF and plasma IL-6 respectively. Beta-Cryptoxanthin 0-18 interleukin 6 Homo sapiens 91-95 24985027-8 2014 beta-cryptoxanthin (P=0.04) and lycopene (P=0.02) inversely correlated with CSF and plasma IL-6 respectively. Lycopene 32-40 interleukin 6 Homo sapiens 91-95 24768708-6 2014 Knockdown of C/EBP homologous protein (CHOP) with small interference RNA partially reversed erlotinib-induced apoptosis, production of IL-6 and down-regulation of E-cadherin in cultured intestinal epithelial cells. Erlotinib Hydrochloride 92-101 interleukin 6 Homo sapiens 135-139 24623048-4 2014 When cultured with dMAT, adipocytes showed decreased lipolysis and adipokine secretion and increased expression/production of cytokines (IL-6, G-CSF) and fibrotic mediators (LOXL2 and the matricellular proteins THSB2 and CTGF). 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole 19-23 interleukin 6 Homo sapiens 137-141 24953430-11 2014 In vitro, the induction of STAT3 phosphorylation by recombinant human IL-6 promoted pancreatic ductal adenocarcinoma cell survival during gemcitabine treatment. gemcitabine 138-149 interleukin 6 Homo sapiens 70-74 24953430-13 2014 In particular, the inflammation biomarkers C-reactive protein, IL-6, and IL-1alpha could indicate the prognostic benefit of gemcitabine chemotherapy and should now be tested in prospective patient-controlled trials. gemcitabine 124-135 interleukin 6 Homo sapiens 63-67 25050011-6 2014 Dietary vitamin E also showed a significant (p<0.05) decrease in the mRNA expression of IL-6 and HSP70 compared with a basal diet. Vitamin E 8-17 interleukin 6 Homo sapiens 91-95 24526008-4 2014 RESULT: Exogenous IL-10 (10(-8 )M) significantly (P<0.05) inhibited the endotoxin-stimulated release of IL-6, IL-8 and tumor necrosis factor by 63 to 82% with no significant effect by DEX and BETA. Betamethasone 195-199 interleukin 6 Homo sapiens 107-111 24736562-4 2014 While PolyI:C induced maximal cytokine and chemokine production from both PHCEC (IFNgamma, CCL2, CCL3, and (CCL4), IL6, CXCL10, CCL5, TNFalpha) and PHKF (CCL2, IL-6, CXCL10, CCL5), only PHKF cytokines were inhibited by GCs. Poly I-C 6-13 interleukin 6 Homo sapiens 160-164 24684779-7 2014 RESULTS: Simvastatin significantly reduced plasma interleukin-6, leptin, resistin and monocyte chemoattractant protein-1 (p < 0.001 for all); pioglitazone reduced interleukin-6, tumoral necrose factor-alpha, resistin and matrix metalloproteinase-9 (p < 0.001 for all). Pioglitazone 145-157 interleukin 6 Homo sapiens 166-179 24684779-8 2014 Simvastatin + pioglitazone treatment further reduced plasmatic variables, including interleukin-6, tumoral necrose factor-alpha, resistin, asymmetric dimethylarginine and metalloproteinase-9 vs. the control group (p < 0.001). Pioglitazone 14-26 interleukin 6 Homo sapiens 84-97 24456369-6 2014 The identified drugs represent a new class of lead compounds with piperidine, benzothiophene, and indole scaffolds to inhibit IL-6 induced homodimerization of GP130. benzothiophene 78-92 interleukin 6 Homo sapiens 126-130 24516502-6 2014 The cytotoxicity of crude extracts on in vitro human skin fibroblast (HSF) cell models was determined by MTT assay. monooxyethylene trimethylolpropane tristearate 105-108 interleukin 6 Homo sapiens 70-73 23775574-8 2013 And also immune reaction was less in patients exposed to desflurane anesthesia when compared to propofol anesthesia as indicated by lower plasma concentrations of IL-8 and IL-6. Propofol 96-104 interleukin 6 Homo sapiens 172-176 24222216-6 2013 The optical densities in MTT assay of the activated, inactivated, and control groups was 1.35 +- 0.11, 1.01 +- 0.09, and 0.29 +- 0.01, respectively, which correlated positively with the initial IL-6 level in the supernatant of the VSMCs (r = 0.63, P < 0.05). monooxyethylene trimethylolpropane tristearate 25-28 interleukin 6 Homo sapiens 194-198 23727622-1 2013 Chronic exposure to arsenic can generate reactive oxidative species, which can induce certain proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-8 (IL-8). Arsenic 20-27 interleukin 6 Homo sapiens 169-182 23727622-1 2013 Chronic exposure to arsenic can generate reactive oxidative species, which can induce certain proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-8 (IL-8). Arsenic 20-27 interleukin 6 Homo sapiens 184-188 23142150-3 2013 In particular, protein levels of Tumor Necrosis Factor (TNF) and the SNPs rs1126757 in interleukin-11 (IL11), and rs7801617 in interleukin-6 (IL6), have previously been implicated in the clinical response to the selective serotonin reuptake inhibitor (SSRI) antidepressant escitalopram. Citalopram 273-285 interleukin 6 Homo sapiens 127-140 21997325-8 2013 Well-controlled DP had lower levels of IL-6 than poorly controlled DP, suggesting that glycemic control may prevent IL6 mRNA alterations associated with diabetes. dp 16-18 interleukin 6 Homo sapiens 39-43 21997325-8 2013 Well-controlled DP had lower levels of IL-6 than poorly controlled DP, suggesting that glycemic control may prevent IL6 mRNA alterations associated with diabetes. dp 16-18 interleukin 6 Homo sapiens 116-119 23559389-6 2013 This study demonstrates in MC + HCV high serum levels of (a) T-helper 1 chemokines, CXCL11 and CXCL10 (related to each other) and (b) proinflammatory cytokines IL-6 and CCL2 (related to each other). Methylcholanthrene 27-31 interleukin 6 Homo sapiens 160-164 23434449-7 2013 At specific postoperative time points, blood glucose, lactic acid, intestinal fatty acid binding protein, D-lactate, lipopolysaccharide, and interleukin-6 were statistically lower in the penehyclidine hydrochloride group than in the control group. Penequine hydrochloride 187-214 interleukin 6 Homo sapiens 141-154 23624712-8 2013 MTT assays showed that IL-6 partially abrogated the BBD9-induced cell growth inhibition. monooxyethylene trimethylolpropane tristearate 0-3 interleukin 6 Homo sapiens 23-27 23650978-0 2013 Tocilizumab: a novel humanized anti-interleukin 6 (IL-6) receptor antibody for the treatment of patients with non-RA systemic, inflammatory rheumatic diseases. Radium 114-116 interleukin 6 Homo sapiens 51-55 23691212-6 2013 By using these recombinant lactococcal constructs, we were able to demonstrate that the SpaCBA pilus can be a contributory factor in the activation of Toll-like receptor 2-dependent signaling in HEK cells as well as in the modulation of pro- and anti-inflammatory cytokine (TNF-alpha, IL-6, IL-10, and IL-12) production in human monocyte-derived dendritic cells. lactococcal 27-38 interleukin 6 Homo sapiens 285-289 23500137-3 2013 In this study, we evaluated the anti-inflammatory activity and mechanisms of propofol on lipopolysaccharide (LPS)-induced inflammation in vivo and in vitro and found that propofol markedly inhibited LPS-induced production of pro-inflammatory cytokines, including tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6, and expression of inducible nitric oxide synthase (iNOS). Propofol 171-179 interleukin 6 Homo sapiens 326-330 23298711-8 2013 Smad4 functioned in this process in a dominant manner, and inhibition by SMAD4 siRNA reduced IL-6 and TGF-beta1 expression, blocked invasion, and reversed EMT and chemoresistance in cells exposed to rh IL-6 and TGF-beta1 and in gemcitabine-resistant cells. gemcitabine 228-239 interleukin 6 Homo sapiens 202-206 23593315-5 2013 In vitro, minocycline was found to significantly suppress both constitutive and IL-1beta or 4-hydroxyestradiol (4-OH-E2)-stimulated IL-6 expression in human ovarian cancer cells; OVCAR-3, SKOV-3 and CAOV-3. 4-hydroxyestradiol 92-110 interleukin 6 Homo sapiens 132-136 23593315-5 2013 In vitro, minocycline was found to significantly suppress both constitutive and IL-1beta or 4-hydroxyestradiol (4-OH-E2)-stimulated IL-6 expression in human ovarian cancer cells; OVCAR-3, SKOV-3 and CAOV-3. 4-hydroxyestradiol 112-119 interleukin 6 Homo sapiens 132-136 23161148-1 2013 We have previously shown that interleukin-6 (IL-6) has neuroprotective effect against N-methyl-D-aspartate (NMDA)-induced excitotoxicity. N-Methylaspartate 108-112 interleukin 6 Homo sapiens 30-43 23161148-1 2013 We have previously shown that interleukin-6 (IL-6) has neuroprotective effect against N-methyl-D-aspartate (NMDA)-induced excitotoxicity. N-Methylaspartate 108-112 interleukin 6 Homo sapiens 45-49 23161148-6 2013 Chronic IL-6 exposure prevented the NMDA-evoked neuronal Ca(2+) overload, cPLA2 expression upregulation, and apoptosis and necrosis. N-Methylaspartate 36-40 interleukin 6 Homo sapiens 8-12 23161148-7 2013 Anti-gp130 monoclonal antibody (mAb), a blocker of gp130 that is a 130-kDa signal-transducing beta-subunit of IL-6 receptor complex, blocked these effects of IL-6 preventing NMDA neurotoxicity. N-Methylaspartate 174-178 interleukin 6 Homo sapiens 110-114 23161148-7 2013 Anti-gp130 monoclonal antibody (mAb), a blocker of gp130 that is a 130-kDa signal-transducing beta-subunit of IL-6 receptor complex, blocked these effects of IL-6 preventing NMDA neurotoxicity. N-Methylaspartate 174-178 interleukin 6 Homo sapiens 158-162 24229459-5 2013 Other variables that improved with pioglitazone were the CRP, IL-6, and patient-reported assessment of global health. Pioglitazone 35-47 interleukin 6 Homo sapiens 62-66 22954322-7 2013 Whereas the poly(I:C)-induced secretion of IL-6, IP-10, and RANTES was inhibited by both IKK-2 inhibitor and LY294002, that of IL-8 was blocked only by IKK-2 inhibitor. Poly I-C 12-21 interleukin 6 Homo sapiens 43-47 22954322-8 2013 CONCLUSIONS: The poly(I:C)-induced secretion of IL-6, IP-10, and RANTES from human corneal fibroblasts is mediated by both NF-kappaB and PI3K signaling pathways, whereas that of IL-8 is mediated by the NF-kappaB pathway. Poly I-C 17-26 interleukin 6 Homo sapiens 48-52 23952947-6 2013 We demonstrated ability of perindopril to affect proinflammatory status: to suppress factors of subclinical inflammation (interleukin-6 and C-reactive protein) and to elevate level of anti-inflammatory interleukin-10. Perindopril 27-38 interleukin 6 Homo sapiens 122-135 23076270-10 2013 CONCLUSION: This study showed that splenic F-FDG uptake is related to IL-1beta, IL-1receptor antagonist, IL-4, IL-6, IL-7, and IL-13. f-fdg 43-48 interleukin 6 Homo sapiens 111-115 30185897-9 2018 Our findings ascertain that miR-301a is an oncogenic miRNA, which targets SMAD4 to establish an essential mechanism for arsenic-induced carcinogenesis, IL-6/STAT3/miR-301a/SMAD4 signaling pathways. Arsenic 120-127 interleukin 6 Homo sapiens 152-156 29885023-0 2018 Tyrosine kinase inhibitor-induced IL-6/STAT3 activation decreases sensitivity of EGFR-mutant non-small cell lung cancer to icotinib. icotinib 123-131 interleukin 6 Homo sapiens 34-38 29885023-7 2018 Further study confirmed that icotinib concomitantly induced IL-6 secretion and src activation in PC9 cells. icotinib 29-37 interleukin 6 Homo sapiens 60-64 29885023-8 2018 Moreover, with the treatment of IL-6 neutralizing antibody or src inhibitor, dasatinib, icotinib-induced phosphorylation of STAT3 was reduced, as well as the sensitivity of PC9 to icotinib was also partially increased. icotinib 88-96 interleukin 6 Homo sapiens 32-36 29885023-8 2018 Moreover, with the treatment of IL-6 neutralizing antibody or src inhibitor, dasatinib, icotinib-induced phosphorylation of STAT3 was reduced, as well as the sensitivity of PC9 to icotinib was also partially increased. icotinib 180-188 interleukin 6 Homo sapiens 32-36 30174670-10 2018 Both inhibition of p38 MAPK by SB203580 (10 microM) and knockdown of ER stress effector CCAAT-enhancer-binding protein homologous protein (CHOP) reduced gene and protein expression of IL-6 in Tg-treated cells. SB 203580 31-39 interleukin 6 Homo sapiens 184-188 29792808-8 2018 Following PAR treatment, the production of IL-2, IFN-gamma, IL-6, and TNF-alpha could be significantly reduced by an infusion of clinically relevant concentrations of the FDA-approved antibiotic, trimethoprim, signaling pharmacologic PAR deactivation. paratose 10-13 interleukin 6 Homo sapiens 60-64 29645296-8 2018 Moreover, Ruxolitinib reduced MSC secretion of MCP-1 and IL-6. ruxolitinib 10-21 interleukin 6 Homo sapiens 57-61 29642242-9 2018 Shikonin attenuated the expression of cyclooxygenase-2 and inducible nitric oxide synthase, and myeloperoxidase activity, and inhibited the production of interleukin-6 and activation of nuclear factor-kappaB. shikonin 0-8 interleukin 6 Homo sapiens 154-167 29653462-8 2018 Compared with that of the group given palmitic acid, attenuation of proinflammatory status was indicated by reduced interleukin-6 (P < .05) and prostaglandin E2 levels. Palmitic Acid 38-51 interleukin 6 Homo sapiens 116-129 29904429-11 2018 Propofol partly inhibited inflammatory cytokine production, including IL-1beta and IL-6, and the anti-inflammatory effect may result from inhibition of JNK-MAPK, and enhanced NF-kappaB and extracellular signal-regulated kinase-MAPK signaling at clinical concentrations. Propofol 0-8 interleukin 6 Homo sapiens 83-87 29164820-3 2018 METHODS & RESULTS: HepG2 cells treated with palmitic acid (PA;0.75 mM) showed decreased expression of various antioxidant biomarkers (SOD1, SOD2, glutathione peroxidase and catalase) and increased expression of inflammatory markers (TNFalpha, IL1beta and IL6). Palmitic Acid 48-61 interleukin 6 Homo sapiens 259-262 29805673-0 2018 Anesthetic drug propofol inhibits the expression of interleukin-6, interleukin-8 and cyclooxygenase-2, a potential mechanism for propofol in suppressing tumor development and metastasis. Propofol 16-24 interleukin 6 Homo sapiens 52-65 29412077-7 2018 Propofol group had increased production of interleukin-6 at T1 and sevoflurane and epidural groups had decreased production of tumor necrosis factor-alpha at T2. Propofol 0-8 interleukin 6 Homo sapiens 43-56 29651140-4 2018 In this context, we investigated in vivo study using the nitrosodiethyl amine (NDEA)-induced HCC model, which strengthened our previous findings by showing the blockade of the IL-6 mediated JAK2/STAT3 oncogenic signaling pathway. Diethylnitrosamine 57-77 interleukin 6 Homo sapiens 176-180 29651140-4 2018 In this context, we investigated in vivo study using the nitrosodiethyl amine (NDEA)-induced HCC model, which strengthened our previous findings by showing the blockade of the IL-6 mediated JAK2/STAT3 oncogenic signaling pathway. Diethylnitrosamine 79-83 interleukin 6 Homo sapiens 176-180 29193446-10 2018 p38MAPK inhibitor SB203580 reduced the development of senescence and IL-6 by TNF-alpha and LPS. SB 203580 18-26 interleukin 6 Homo sapiens 69-73 29245047-6 2018 Conversely, pretreatment with SB203580, a selective inhibitor of p38 MAPK, blocked p38 MAPK phosphorylation and IL-6 and IL-8 expression. SB 203580 30-38 interleukin 6 Homo sapiens 112-116 29245047-7 2018 In conclusion, polyI:C induces IL-6 and IL-8 production in HDFs via the JAK/STAT3 and p38 MAPK signaling pathways. Poly I-C 15-22 interleukin 6 Homo sapiens 31-35 29162613-0 2018 The JAK1/2 Inhibitor Ruxolitinib Reverses Interleukin-6-Mediated Suppression of Drug-Detoxifying Proteins in Cultured Human Hepatocytes. ruxolitinib 21-32 interleukin 6 Homo sapiens 42-55 29162613-3 2018 In the present study, we investigated whether ruxolitinib, a small drug acting as a JAK1/2 inhibitor and currently used in the treatment of myeloproliferative neoplasms, may also counteract the repressing effects of IL-6 toward hepatic detoxifying systems. ruxolitinib 46-57 interleukin 6 Homo sapiens 216-220 29162613-4 2018 Ruxolitinib was found to fully inhibit IL-6-mediated repression of P450 (CYP1A2, CYP2B6, and CYP3A4) and transporter (NTCP, OATP1B1, and OCT1) mRNA levels in primary human hepatocytes and differentiated hepatoma HepaRG cells. ruxolitinib 0-11 interleukin 6 Homo sapiens 39-43 29162613-8 2018 Taken together, our results demonstrated that small drugs acting as JAK inhibitors, like ruxolitinib, counteract IL-6-mediated repression of drug-metabolizing enzymes and drug transporters in cultured human hepatocytes. ruxolitinib 89-100 interleukin 6 Homo sapiens 113-117 28840599-0 2018 Butyltin compounds alter secretion of interleukin 6 from human immune cells. n-butyltin 0-8 interleukin 6 Homo sapiens 38-51 29388547-11 2018 Ruxolitinib caused a significant increase in the production of IL-6, IL-8 and TNF-alpha in stimulated cells. ruxolitinib 0-11 interleukin 6 Homo sapiens 63-67 29568569-5 2018 Results: One such material, synthesized from chondroitin sulfate type A and serotonin in the presence of Cu2+ was found to affect the release of IL-1beta and IL-6 cytokines from immune cells. Chondroitin Sulfates 45-64 interleukin 6 Homo sapiens 158-162 28945228-6 2018 Moreover, when compared with a pharmacologic inhibitor or silencing of STAT3, trametinib, a MEK inhibitor, in combination with NVP-BKM120 yielded more potent anti-proliferative effects by inhibiting S phase transition, arresting cells at G0/G1 phase, and downregulating IL-6 and c-Myc expression. trametinib 78-88 interleukin 6 Homo sapiens 270-274 30001540-13 2018 Obeticholic acid, an agonist of FXR, inhibited IL-6 production, tumor growth and lung metastasis of ICC in vivo. obeticholic acid 0-16 interleukin 6 Homo sapiens 47-51 29727764-7 2018 Multivariable regression analysis revealed that IL-6, education level, hypertension, and dialysis duration were significant predictors of HADS-D. hads-d 138-144 interleukin 6 Homo sapiens 48-52 29693510-6 2018 Exposure to cbUFP + O3 significantly increased plasma club cell protein 16 (CC16), the number of sputum cells, the number and percent of sputum neutrophils, and sputum interleukin 6 and matrix metalloproteinase 9. cbufp + o3 12-22 interleukin 6 Homo sapiens 168-212 29228979-8 2017 RESULTS: We demonstrate that bryostatin-1 induces secretion of chemokines CCL2 and IL-8 and proinflammatory cytokines IL-6 and GM-CSF, whereas their production is repressed by JQ1. bryostatin 1 29-41 interleukin 6 Homo sapiens 118-122 29058460-2 2017 In the present study, we demonstrated that ginsenoside Rg1 induced secretion of cytokines, including interleukin (IL)-6, tumor necrosis factor-alpha (TNF-alpha), and IL-1beta, and chemokines such as IL-8 and IP-10 in a dose-dependent manner by human peripheral blood mononuclear cell (PBMC)-derived dendritic cells. Ginsenosides 43-54 interleukin 6 Homo sapiens 101-119 29096558-10 2017 Analyses also showed that expression levels of Ahr correlated to those of IL-6 and IL-22 in the dioxin-exposed people. Dioxins 96-102 interleukin 6 Homo sapiens 74-78 29750184-6 2018 Results: In samples from 14 patients we confirmed a strongly compartmentalized immune response at the disease site and found that prednisolone significantly reduced IL-6 concentrations in plasma by 8 hours of treatment, IL-1beta concentrations in saliva, as well as IL-8 concentrations in both pericardial fluid and saliva by 24 hours. Prednisolone 130-142 interleukin 6 Homo sapiens 165-169 28736282-8 2017 Curcumin inhibited the proliferation of IMQ-induced differentiated HaCaT cells (Psoriatic-like cells) by down-regulation of pro-inflammatory cytokines, interleukin-17, tumor necrosis factor-alpha, interferon-gamma, and interleukin-6. Imiquimod 40-43 interleukin 6 Homo sapiens 219-232 28808571-7 2017 TNF-alpha and IL-6 levels were significantly decreased (P<0.05) by the effect of mCRP and pCRP combined with oxLDL. pcrp 93-97 interleukin 6 Homo sapiens 14-18 27742738-9 2017 Conclusion: Among asymptomatic intermediate-risk patients, the presence of increased IL6 levels in addition to traditional risk factors (male gender with diabetes) and carotid artery disease predicts higher rates of obstructive CAD and it could be of help to identify which subset of asymptomatic patients could be referred to CCTA for screening. ccta 327-331 interleukin 6 Homo sapiens 85-88 28319722-5 2017 Our results demonstrated that BPS exposure induced pro-inflammatory phenotype by activating the immuno-related cytokines which include TNF-alpha, IL-1beta and IL-6, modulating metabolic pathways which include glycolytic, glutathione (GSH), sphingomyelin (SM)-ceramide (Cer), glycerophospholipids (GPs) and glycerolipids (GLs). bis(4-hydroxyphenyl)sulfone 30-33 interleukin 6 Homo sapiens 159-163 28784136-17 2017 These results further suggest that inhibition of STAT3 phosphorylation in the RAB3C-IL-6-STAT3 axis by using Ruxolitinib may be a new therapeutic strategy to combat metastatic colon cancers. ruxolitinib 109-120 interleukin 6 Homo sapiens 84-88 28515374-7 2017 PPI reversed EMT and decreased interleukin-6/signal transducer and activator of transcription 3 (IL-6/STAT3) signaling pathway activation in erlotinib-resistant cells. Erlotinib Hydrochloride 141-150 interleukin 6 Homo sapiens 97-101 28798905-11 2017 Regardless of the T. gondii strain, BeWo cells infected and treated with enrofloxacin or toltrazuril induced high levels of IL-6 and MIF. toltrazuril 89-100 interleukin 6 Homo sapiens 124-128 28794655-10 2017 Further evidence indicated that P2Y12 and P2Y13 receptor-evoked increased gene expression of IL-1beta, IL-6 and TNF-alpha were inhibited by Y-27632 (ROCK inhibitor), SB203580 (P38MAPK inhibitor) and PDTC (NF-kappab inhibitor), respectively. SB 203580 166-174 interleukin 6 Homo sapiens 103-107 28794655-11 2017 Subsequently, P2Y12 and P2Y13 receptor-evoked release of IL-1beta, IL-6 and TNF-alpha, were also inhibited by Y-27632, SB203580 and PDTC, respectively. SB 203580 119-127 interleukin 6 Homo sapiens 67-71 29798960-0 2017 Effect of levamisole on expression of CD138 and interleukin-6 in human multiple myeloma cell lines. Levamisole 10-20 interleukin 6 Homo sapiens 48-61 29798960-9 2017 RESULTS: Levamisole-mediated growth inhibition of myeloma cells in vitro is associated with a loss of CD138 and increased IL-6 secretion. Levamisole 9-19 interleukin 6 Homo sapiens 122-126 29798960-11 2017 CONCLUSION: Levamisole inhibited CD138 expression and affected the levels of IL-6 in a dose-dependent manner. Levamisole 12-22 interleukin 6 Homo sapiens 77-81 29798960-12 2017 The results of the present study add new dimension to levamisole"s mode of action as inhibitor of CD138 and IL-6 and as an antiapoptotic agent. Levamisole 54-64 interleukin 6 Homo sapiens 108-112 28187299-2 2017 In this work, regenerated cellulose immuno-affinity membranes were developed and they were used for the selective capture of interleukin-6 (IL-6) as targeted antigen. Cellulose 26-35 interleukin 6 Homo sapiens 125-138 28187299-2 2017 In this work, regenerated cellulose immuno-affinity membranes were developed and they were used for the selective capture of interleukin-6 (IL-6) as targeted antigen. Cellulose 26-35 interleukin 6 Homo sapiens 140-144 28761837-0 2017 Human Bone Marrow-Derived Mesenchymal Cell Reactions to 316L Stainless Steel: An in Vitro Study on Cell Viability and Interleukin-6 Expression. Stainless Steel 61-76 interleukin 6 Homo sapiens 118-131 28529032-0 2017 Synergistic Cytotoxicity of Lenalidomide and Dexamethasone in Mantle Cell Lymphoma via Cereblon-dependent Targeting of the IL-6/STAT3/PI3K Axis. Lenalidomide 28-40 interleukin 6 Homo sapiens 123-127 28529032-2 2017 Cereblon is probably targeted by both lenalidomide and dexamethasone, which leads to synergistic cytotoxicity in MCL by inhibiting the interleukin-6/signal transducer and activator of transcription 3 (IL-6/STAT3), phosphatidylinositol 3-kinase (PI3K)/AKT and AKT2/Forkhead box O3 (FOXO3A)/BCL2-like 11 (BIM) pathways. Lenalidomide 38-50 interleukin 6 Homo sapiens 201-205 28276734-5 2017 In addition, we also showed that 6-hydroxyrubiadin inhibited the expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 in phorbol myristate acetate (PMA)-primed U937 and RAW 264.7 cells. 6-Hydroxyrubiadin 33-50 interleukin 6 Homo sapiens 141-145 27821605-9 2017 Multivariate analyses identified IL6 and IL8 as independent predictors of OS.Conclusions: Foretinib demonstrated promising antitumor activity and good tolerability in the first-line setting in Asian advanced hepatocellular carcinoma patients. GSK 1363089 90-99 interleukin 6 Homo sapiens 33-36 28372661-10 2017 Postoperatively, plasma S-100beta and Abeta1-40 protein, IL-1beta, IL-6, and TNF-alpha concentrations were significantly decreased in the propofol group compared to the isoflurane group. Propofol 138-146 interleukin 6 Homo sapiens 67-71 28420169-3 2017 Nanotube biosensors were functionalized with 1-Pyrenebutanoic Acid Succinimidyl Ester (PASE) conjugated IL-6 aptamers. 1-Pyrenebutyric acid N-hydroxysuccinimide ester 45-85 interleukin 6 Homo sapiens 104-108 28109910-6 2017 IL-6 or ADT can induce NED in PCa cells via peroxisome proliferator-activated receptor gamma (PPARgamma, a major lipogenic transcription factor) and adipocyte differentiation-related protein (ADRP, a major component of adiposome). ned 23-26 interleukin 6 Homo sapiens 0-4 28052863-5 2017 Poly(I:C) increased the production of IL-6, IL-8, monocyte chemoattractant protein-1, and ICAM-1. Poly I-C 0-8 interleukin 6 Homo sapiens 38-42 28386381-8 2017 RESULTS: In cells treated with lycopene and LPS, the mRNA expression of TNF-alpha, IL-1beta, IL-6, iNOS, and COX-2 were decreased significantly in a dose-dependent manner (P < 0.05). Lycopene 31-39 interleukin 6 Homo sapiens 93-97 28386381-11 2017 CONCLUSIONS: Lycopene restrains NF-kappaB and JNK activation, which causes inflammation, and suppresses the expression of TNF-alpha, IL-1beta, IL-6, COX-2, and iNOS in SW480 human colorectal cancer cells. Lycopene 13-21 interleukin 6 Homo sapiens 143-147 27909869-9 2017 omega3-polyunsaturated fatty intake also decreased the serum concentrations of interleukin-6 and C-reactive protein (p < 0.05). omega3-polyunsaturated fatty 0-28 interleukin 6 Homo sapiens 79-92 28394395-4 2017 The results showed that the induction of the expression of IL1B, IL6 and CXCLi2 by poly I:C, LPS, and CpG-ODN were suppressed by Bay11-7085, but not by tanshinone IIA. Poly I-C 83-91 interleukin 6 Homo sapiens 65-68 28205610-3 2017 CR-LAAO induced acute inflammatory responses in vivo, with recruitment of neutrophils and release of IL-6, IL-1beta, LTB4 and PGE2. cr-laao 0-7 interleukin 6 Homo sapiens 101-105 28205610-4 2017 In vitro, IL-6 and IL-1beta production by peritoneal macrophages stimulated with CR-LAAO was dependent of the activation of the Toll-like receptors TLR2 and TLR4. cr-laao 81-88 interleukin 6 Homo sapiens 10-14 28205610-5 2017 In addition, CR-LAAO promoted apoptosis of HL-60 and HepG2 tumor cells mediated by the release of hydrogen peroxide and activation of immune cells, resulting in oxidative stress and production of IL-6 and IL-1beta that triggered a series of events, such as activation of caspase 8, 9 and 3, and the expression of the pro-apoptotic gene BAX. cr-laao 13-20 interleukin 6 Homo sapiens 196-200 27835873-4 2017 6-OAP formed hydrogen bonds with Ser611/Ser613/Arg609 at the SH2 domain of STAT3 and inhibited the constitutive and interleukin-6-induced phosphorylated STAT3 (pSTAT3), leading to inhibitory effects on lung cancer cells and suppression of Skp2 transcription. 6-O-angeloylprenolin 0-5 interleukin 6 Homo sapiens 116-129 27404795-0 2017 Histone deacetylase inhibitor vorinostat (SAHA, MK0683) perturb miR-9-MCPIP1 axis to block IL-1beta-induced IL-6 expression in human OA chondrocytes. Vorinostat 30-40 interleukin 6 Homo sapiens 108-112 27404795-0 2017 Histone deacetylase inhibitor vorinostat (SAHA, MK0683) perturb miR-9-MCPIP1 axis to block IL-1beta-induced IL-6 expression in human OA chondrocytes. Vorinostat 42-46 interleukin 6 Homo sapiens 108-112 27404795-0 2017 Histone deacetylase inhibitor vorinostat (SAHA, MK0683) perturb miR-9-MCPIP1 axis to block IL-1beta-induced IL-6 expression in human OA chondrocytes. Vorinostat 48-54 interleukin 6 Homo sapiens 108-112 27404795-3 2017 Vorinostat (SAHA) inhibits the IL-6 expression in OA chondrocytes. Vorinostat 0-10 interleukin 6 Homo sapiens 31-35 27404795-3 2017 Vorinostat (SAHA) inhibits the IL-6 expression in OA chondrocytes. Vorinostat 12-16 interleukin 6 Homo sapiens 31-35 27404795-4 2017 We investigated whether SAHA suppresses the expression of IL-6 by perturbing the miR-9-MCPIP1 axis in OA chondrocytes under pathological conditions. Vorinostat 24-28 interleukin 6 Homo sapiens 58-62 27404795-16 2017 CONCLUSIONS: Taken together our data indicate that SAHA-mediated suppression of the IL-6 expression is achieved through increased recruitment of CEBPalpha to the MCPIP1 promoter and by relieving the miR-9-mediated inhibition of MCPIP1 expression in OA chondrocytes. Vorinostat 51-55 interleukin 6 Homo sapiens 84-88 28465707-7 2017 The downmodulation of IL-6 by P. cicadae was inhibited by the p38 inhibitor (SB203580) or JNK inhibitor (SP600125). SB 203580 77-85 interleukin 6 Homo sapiens 22-26 28626770-7 2017 siTIPE2 infection exacerbated the increased TNF-alpha and IL-6 concentrations in differentiated THP-1 cells under high glucose conditions (50 mmol/L), while infection with TIPE2 adenovirus reversed the increased TNF-alpha concentration. sitipe2 0-7 interleukin 6 Homo sapiens 58-62 29098203-9 2017 At week 48, several LPC molecules containing SaFAs were positively correlated with levels of sCD14, D-dimer, and TNFR1 (P < 0.01), and levels of PUFA-containing LPC (18:3, 20:5, 22:5, 22:6) were positively correlated with CD4+ T cell counts and inversely correlated with sCD14 and IL-6 (P < 0.01). safas 45-50 interleukin 6 Homo sapiens 284-288 27995982-10 2016 P38 inhibitor SB203580 suppressed IL-6 production, and inhibition of IL-6 receptor (IL-6R) activation by tocilizumab suppressed Fos expression. SB 203580 14-22 interleukin 6 Homo sapiens 34-38 27639126-8 2016 PA-induced secretion of TNF-alpha, IL-6, and expression of ICAM-1 at protein and mRNA levels, which was significantly inhibited by APN. Palmitic Acid 0-2 interleukin 6 Homo sapiens 35-39 27575568-7 2016 4-OPA [50muM] treatment of A549 increased IL-6 (1.4-times) and IL-8 (1.3-times) levels, while in 16HBE14o- had an opposite effect. 4-oxopentanal 0-5 interleukin 6 Homo sapiens 42-46 27575568-8 2016 A549 treated with 4-AMCH [50muM] elevate both IL-6 and IL-8 levels by 1.2-times, while in 16HBE14o- had an opposite effect. 4-acetyl-1-methylcyclohexene 18-24 interleukin 6 Homo sapiens 46-50 27716424-7 2016 In BEAS-2B cells, both SE-A and SE-R inhibited the increase in production of the inflammatory cytokines IL-6 and IL-8. se-a 23-27 interleukin 6 Homo sapiens 104-108 27555113-0 2016 Histone Deacetylase Inhibitor Vorinostat (SAHA) Suppresses IL-1beta-Induced Matrix Metallopeptidase-13 Expression by Inhibiting IL-6 in Osteoarthritis Chondrocyte. Vorinostat 30-40 interleukin 6 Homo sapiens 128-132 27555113-0 2016 Histone Deacetylase Inhibitor Vorinostat (SAHA) Suppresses IL-1beta-Induced Matrix Metallopeptidase-13 Expression by Inhibiting IL-6 in Osteoarthritis Chondrocyte. Vorinostat 42-46 interleukin 6 Homo sapiens 128-132 27555113-10 2016 Of importance is our finding that IL-6-stimulated MMP-13 expression was independent of IL-1beta stimulation and was blocked by SAHA, suggesting that SAHA inhibits IL-6 signaling in OA chondrocytes. Vorinostat 127-131 interleukin 6 Homo sapiens 34-38 27555113-10 2016 Of importance is our finding that IL-6-stimulated MMP-13 expression was independent of IL-1beta stimulation and was blocked by SAHA, suggesting that SAHA inhibits IL-6 signaling in OA chondrocytes. Vorinostat 127-131 interleukin 6 Homo sapiens 163-167 27555113-10 2016 Of importance is our finding that IL-6-stimulated MMP-13 expression was independent of IL-1beta stimulation and was blocked by SAHA, suggesting that SAHA inhibits IL-6 signaling in OA chondrocytes. Vorinostat 149-153 interleukin 6 Homo sapiens 34-38 27555113-10 2016 Of importance is our finding that IL-6-stimulated MMP-13 expression was independent of IL-1beta stimulation and was blocked by SAHA, suggesting that SAHA inhibits IL-6 signaling in OA chondrocytes. Vorinostat 149-153 interleukin 6 Homo sapiens 163-167 27517907-4 2016 CML or pentosidine at 4-16 mumol/L promoted invasion and migration in both cell lines, and increased the production of reactive oxygen species, tumor necrosis factor-alpha, interleukin-6 and transforming growth factor-beta1. pentosidine 7-18 interleukin 6 Homo sapiens 173-223 27240190-4 2016 Our results show that 7-hydroxycoumarin (7-OHC) prevents UVB-induced activation of NF-kappaB thereby subsequently preventing the overexpression of TNF-alpha and IL-6 in HDFa cells. 7-HYDROXYCHOLESTEROL 41-46 interleukin 6 Homo sapiens 161-165 27300134-10 2016 Moreover, palmitic acid stimulated caspase-3 activation and inflammatory cytokine secretion (e.g., IL-6 and IL-8). Palmitic Acid 10-23 interleukin 6 Homo sapiens 99-103 27455959-10 2016 In patients, prednisolone abolished symptoms, normalized C-reactive protein, and reduced melatonin, IL-6, IL-8, and TNF-alpha concentrations (2P < 0.05), while IL-10 increased between 10:00 and 14:00. Prednisolone 13-25 interleukin 6 Homo sapiens 100-104 27111514-7 2016 Astilbin suppressed the activities of myeloperoxidase and malondialdehyde, as well as the expression of tumor necrosis factor-alpha and interleukin-6 in vivo and in vitro. astilbin 0-8 interleukin 6 Homo sapiens 136-149 27034404-4 2016 In vitro, we showed that fungal killing by IL-6/23-stimulated human peripheral blood neutrophils was impaired by JAK/STAT inhibitors Ruxolitinib and Stattic, and by the retinoic acid receptor-related orphan receptor gammat inhibitor SR1001. ruxolitinib 133-144 interleukin 6 Homo sapiens 43-47 26868135-9 2016 In the supernatants obtained after cell incubation with serum from sulodexide treated patients, the increase in concentrations of IL-6, MCP-1 and ICAM-1 was significantly less than the control. glucuronyl glucosamine glycan sulfate 67-77 interleukin 6 Homo sapiens 130-134 26248159-4 2016 Treatment of PASMCs with the PAH mediators platelet-derived growth factor (PDGF), serotonin, H2O2, endothelin-1, and IL-6 caused significant increases in calpain activity, cell proliferation, and collagen-I protein level without changes in protein levels of calpain-1 and -2. pasmcs 13-19 interleukin 6 Homo sapiens 117-121 26847351-10 2016 We also found that IL-6/STAT3 promoted SOCS3 promoter hypermethylation by increasing DNMT1 activity; silencing DNMT1 or 5-aza-2-deoxycytidine (5-AZA) treatment could reverse the down-regulation of SOCS3 mediated by IL-6. Decitabine 120-141 interleukin 6 Homo sapiens 19-23 26847351-10 2016 We also found that IL-6/STAT3 promoted SOCS3 promoter hypermethylation by increasing DNMT1 activity; silencing DNMT1 or 5-aza-2-deoxycytidine (5-AZA) treatment could reverse the down-regulation of SOCS3 mediated by IL-6. Decitabine 120-141 interleukin 6 Homo sapiens 215-219 26847351-10 2016 We also found that IL-6/STAT3 promoted SOCS3 promoter hypermethylation by increasing DNMT1 activity; silencing DNMT1 or 5-aza-2-deoxycytidine (5-AZA) treatment could reverse the down-regulation of SOCS3 mediated by IL-6. Decitabine 143-148 interleukin 6 Homo sapiens 19-23 26847351-10 2016 We also found that IL-6/STAT3 promoted SOCS3 promoter hypermethylation by increasing DNMT1 activity; silencing DNMT1 or 5-aza-2-deoxycytidine (5-AZA) treatment could reverse the down-regulation of SOCS3 mediated by IL-6. Decitabine 143-148 interleukin 6 Homo sapiens 215-219 26410851-5 2016 Our results demonstrated that piperine attenuated LPS-induced MPO activity, lung edema, and inflammatory cytokines TNF-alpha, IL-6, and IL-1beta production. lps 50-53 interleukin 6 Homo sapiens 126-130 27941341-7 2016 Sulodexide (0.5 LRU/mL) reduced atherosclerotic serum-induced increased expression of genes for IL-6 (-32%), VCAM-1 (-20%) and VWF (-42%), and lowered secretion of these molecules: IL-6 (-27%), VCAM-1(-27%), VWF (-25%). glucuronyl glucosamine glycan sulfate 0-10 interleukin 6 Homo sapiens 96-100 27941341-7 2016 Sulodexide (0.5 LRU/mL) reduced atherosclerotic serum-induced increased expression of genes for IL-6 (-32%), VCAM-1 (-20%) and VWF (-42%), and lowered secretion of these molecules: IL-6 (-27%), VCAM-1(-27%), VWF (-25%). glucuronyl glucosamine glycan sulfate 0-10 interleukin 6 Homo sapiens 181-185 27941341-8 2016 Sulodexide also reduced, in a dose- dependent manner, secretion of IL6 from unstimulated and stimulated with IL-1 endothelial cells. glucuronyl glucosamine glycan sulfate 0-10 interleukin 6 Homo sapiens 67-70 26578520-10 2016 The secretome of hypoxic palmitate-treated macrophages promoted IL-6 and macrophage chemoattractant protein 1 expression in primary human adipocytes, which was sensitive to macrophage JNK inhibition. hypoxic palmitate 17-34 interleukin 6 Homo sapiens 64-68 27006530-0 2016 IL-6 Inhibition Reduces STAT3 Activation and Enhances the Antitumor Effect of Carboplatin. Carboplatin 78-89 interleukin 6 Homo sapiens 0-4 27006530-4 2016 In this study, we aimed to investigate the effect of IL-6 inhibition therapy on the antitumor effect of carboplatin. Carboplatin 104-115 interleukin 6 Homo sapiens 53-57 27006530-6 2016 Treatment of carboplatin (CBP) dose-dependently increased IL-6 production and STAT3 activation in human colorectal LoVo cells. Carboplatin 13-24 interleukin 6 Homo sapiens 58-62 27006530-6 2016 Treatment of carboplatin (CBP) dose-dependently increased IL-6 production and STAT3 activation in human colorectal LoVo cells. Carboplatin 26-29 interleukin 6 Homo sapiens 58-62 27006530-7 2016 Blockade of IL-6 with neutralizing antibody enhanced chemosensitivity of LoVo cells to carboplatin as evidenced by increased cell apoptosis. Carboplatin 87-98 interleukin 6 Homo sapiens 12-16 27006530-8 2016 IL-6 blockade abolished carboplatin-induced STAT3 activation. Carboplatin 24-35 interleukin 6 Homo sapiens 0-4 26593037-4 2015 Chicoric acid decreased the mRNA expression of pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-1beta. chicoric acid 0-13 interleukin 6 Homo sapiens 118-136 26044841-12 2015 Synthesis of IL-6 was lower in HVEC exposed in vitro to serum collected at the end of SUL treatment: 1.02+-0.31 ng/mug cell protein vs. 1.32+-0.41 ng/mug cell protein before SUL treatment. glucuronyl glucosamine glycan sulfate 86-89 interleukin 6 Homo sapiens 13-17 25986861-1 2015 Oncostatin M (OSM), a cytokine in the interleukin-6 (IL-6) family, has been proposed to play a protective role in the central nervous system, such as attenuation of excitotoxicity induced by N-methyl-D-aspartate (NMDA) and glutamate. N-Methylaspartate 191-211 interleukin 6 Homo sapiens 53-57 25986861-1 2015 Oncostatin M (OSM), a cytokine in the interleukin-6 (IL-6) family, has been proposed to play a protective role in the central nervous system, such as attenuation of excitotoxicity induced by N-methyl-D-aspartate (NMDA) and glutamate. N-Methylaspartate 213-217 interleukin 6 Homo sapiens 53-57 25876063-5 2015 Osthole was able to suppress the levels of proinflammatory cytokines interleukin (IL)-1beta and IL-6, as well as chemokines monocyte chemoattractant protein-1 and IL-8. osthol 0-7 interleukin 6 Homo sapiens 96-100 25987541-10 2015 IL-1beta-increased IL-6 release was reduced with cytochalasin B, epalrestat, L-NAME or MitoTEMPO treatment (-45%, -62%, -38% and -40%, respectively). NG-Nitroarginine Methyl Ester 77-83 interleukin 6 Homo sapiens 19-23 25888065-5 2015 Blockade of IL-6 signaling using the IL-6 receptor antagonist tocilizumab, was able to overcome erlotinib-resistance in erlotinib-resistant SQ20B tumors in vivo. Erlotinib Hydrochloride 96-105 interleukin 6 Homo sapiens 12-16 25888065-5 2015 Blockade of IL-6 signaling using the IL-6 receptor antagonist tocilizumab, was able to overcome erlotinib-resistance in erlotinib-resistant SQ20B tumors in vivo. Erlotinib Hydrochloride 96-105 interleukin 6 Homo sapiens 37-41 25888065-5 2015 Blockade of IL-6 signaling using the IL-6 receptor antagonist tocilizumab, was able to overcome erlotinib-resistance in erlotinib-resistant SQ20B tumors in vivo. Erlotinib Hydrochloride 120-129 interleukin 6 Homo sapiens 12-16 25888065-5 2015 Blockade of IL-6 signaling using the IL-6 receptor antagonist tocilizumab, was able to overcome erlotinib-resistance in erlotinib-resistant SQ20B tumors in vivo. Erlotinib Hydrochloride 120-129 interleukin 6 Homo sapiens 37-41 25888065-6 2015 Overall, erlotinib-resistant HNSCC cells display elevated IL-6 expression levels compared to erlotinib-sensitive HNSCC cells and blockade of the IL-6 signaling pathway may be an effective strategy to overcome resistance to erlotinib and possibly other EGFR TKIs for HNSCC therapy. Erlotinib Hydrochloride 9-18 interleukin 6 Homo sapiens 58-62 25888065-6 2015 Overall, erlotinib-resistant HNSCC cells display elevated IL-6 expression levels compared to erlotinib-sensitive HNSCC cells and blockade of the IL-6 signaling pathway may be an effective strategy to overcome resistance to erlotinib and possibly other EGFR TKIs for HNSCC therapy. Erlotinib Hydrochloride 9-18 interleukin 6 Homo sapiens 145-149 25845399-6 2015 In addition, the accumulation of TGF-alpha and interleukin-6 (IL-6) production induced by LPS in the culture supernatant was found to be decreased dose-dependently with sesamin pretreatment in PC3 cells using the enzyme-linked immunosorbent assay (ELISA) kit. sesamin 169-176 interleukin 6 Homo sapiens 47-60 25845399-6 2015 In addition, the accumulation of TGF-alpha and interleukin-6 (IL-6) production induced by LPS in the culture supernatant was found to be decreased dose-dependently with sesamin pretreatment in PC3 cells using the enzyme-linked immunosorbent assay (ELISA) kit. sesamin 169-176 interleukin 6 Homo sapiens 62-66 25843793-6 2015 beta-adrenoreceptor inhibitor propranolol blocked NE-induced IL-6 expression in mRNA and protein levels in U937 macrophages. Propranolol 30-41 interleukin 6 Homo sapiens 61-65 25795558-4 2015 METHODS: Human cardiac MIC ECs were treated with LPS, PA and LPS plus PA and the regulatory pathways including receptors, signal transduction, transcription and post-transcription, and sphingolipid metabolism for IL-6 expression were investigated. Palmitic Acid 54-56 interleukin 6 Homo sapiens 213-217 25795558-5 2015 RESULTS: G protein-coupled receptor (GPR)40 or free fatty acid receptor 1 (FFA1), but not toll-like receptor 4, was involved in PA-stimulated IL-6 expression. Palmitic Acid 128-130 interleukin 6 Homo sapiens 142-146 25795558-6 2015 PA not only stimulated IL-6 expression by itself, but also remarkably enhanced LPS-stimulated IL-6 expression via a cooperative stimulation on mitogen-activated protein kinase and nuclear factor kappa B signaling pathways, and both transcriptional and post-transcriptional activation. Palmitic Acid 0-2 interleukin 6 Homo sapiens 23-27 25795558-6 2015 PA not only stimulated IL-6 expression by itself, but also remarkably enhanced LPS-stimulated IL-6 expression via a cooperative stimulation on mitogen-activated protein kinase and nuclear factor kappa B signaling pathways, and both transcriptional and post-transcriptional activation. Palmitic Acid 0-2 interleukin 6 Homo sapiens 94-98 25795558-7 2015 Furthermore, PA induced a robust neutral sphingomyelinase (nSMase)-mediated sphingomyelin hydrolysis that was involved in PA-augmented IL-6 upregulation. Palmitic Acid 13-15 interleukin 6 Homo sapiens 135-139 25795558-7 2015 Furthermore, PA induced a robust neutral sphingomyelinase (nSMase)-mediated sphingomyelin hydrolysis that was involved in PA-augmented IL-6 upregulation. Palmitic Acid 122-124 interleukin 6 Homo sapiens 135-139 26060346-7 2015 Following astaxanthin treatment, localization of nuclear factor kappaB/p65 and the level of inflammatory cytokines (interleukin-6, tumor necrosis factor-alpha) tended to decrease, and cell proliferation significantly increased in vitro. astaxanthine 10-21 interleukin 6 Homo sapiens 116-158 25662545-14 2015 CONCLUSIONS: In conclusion, these results might suggest that glucosamine-chondroitin combination significantly increases the MMO and decreases the synovial fluid IL1beta and IL6 levels in internal derangements of TMJ compared to tramadol. Chondroitin 73-84 interleukin 6 Homo sapiens 174-177 25712126-5 2015 Erlotinib significantly upregulated IL6 secretion in HNSCC cell lines, which our laboratory previously reported to result in reduced drug efficacy. Erlotinib Hydrochloride 0-9 interleukin 6 Homo sapiens 36-39 25712126-6 2015 Suppression of MyD88 expression blocked erlotinib-induced IL6 secretion in vitro and increased the antitumor activity of erlotinib in vivo. Erlotinib Hydrochloride 40-49 interleukin 6 Homo sapiens 58-61 25712126-8 2015 However, suppression of IL1R signaling significantly reduced erlotinib-induced IL6 production. Erlotinib Hydrochloride 61-70 interleukin 6 Homo sapiens 79-82 25515776-9 2015 The production of IL6 and IL8 was also suppressed by p38 inhibitor SB203580. SB 203580 67-75 interleukin 6 Homo sapiens 18-21 25690135-16 2015 ACN extract and M3G significantly attenuated TNF-alpha-stimulated low-grade leukocyte adhesion, expression of adhesion molecules E-selectin, VCAM-1 and ICAM-1 and cytokine expression and secretion (IL-8 and IL-6) as well as NF-kappaB mRNA expression. Anthocyanins 0-3 interleukin 6 Homo sapiens 207-211 25734515-10 2015 Additionally, wortmannin had similar effects on IL-6, p-PKB (Ser473) to PKB ratio, and p-IkappaBalpha to IkappaBalpha ratio as 1pM cortisone or dexamethasone. Wortmannin 14-24 interleukin 6 Homo sapiens 48-52 25454806-6 2015 Inhibition studies by using wortmannin abrogated NF-kappaB-mediated IL-6 and IL-8 expression, suggesting the requirement of PI3K/Akt pathway. Wortmannin 28-38 interleukin 6 Homo sapiens 68-72 25669986-7 2015 In addition, Nap caused an increase of IL-6, IL-10 and TNF-alpha. nap 13-16 interleukin 6 Homo sapiens 39-43 25545218-4 2015 In vitro-generated LCs expressed TLR1-10 and robustly produced IL-6 and TNF-alpha in response to PolyI:C, but pre-exposure to L3s did not alter inflammatory cytokine production or TLR expression. Poly I-C 97-104 interleukin 6 Homo sapiens 63-67 24285492-11 2015 Extracellular and intracellular TLR4 inhibition as well as fatty acid transport inhibition blocked the palmitic acid-induced IL-6 secretion of RASF. Palmitic Acid 103-116 interleukin 6 Homo sapiens 125-129 25227901-12 2015 [Lancet 2008;371:205-214] reported CAPRA-1, which documented that modified-release prednisone or prednisolone taken at bedtime led to lower morning stiffness and IL-6 levels compared to usual morning prednisone. Prednisolone 97-109 interleukin 6 Homo sapiens 162-166 25670984-10 2014 The production of IL-6 by LPS-activated moDC was also reduced significantly when eicosapentaenic acid was added as a RAMEA complex as compared to its DMSO-solubilized form or to the other two n-3 fatty acids either complexed or not. ramea 117-122 interleukin 6 Homo sapiens 18-22 25671204-7 2014 Significant decreases in the post training values of weight, % Fat, BMI, IL-6 and CRP (p < .05) were observed in the CTG compared to pre-training. ctg 120-123 interleukin 6 Homo sapiens 73-85 25091291-5 2014 When challenged with a well-characterized biopolymer, poly(lactic-co-glycolic acid), the co-cultured human cells secreted elevated levels of IL-1beta, IL-6, GM-CSF and TNF-alpha. Polylactic Acid-Polyglycolic Acid Copolymer 54-82 interleukin 6 Homo sapiens 151-155 25280420-8 2014 Palmitic acid was marginally associated with the composite inflammation measure (P = 0.06) and, upon additional omega-6 FA adjustment, significantly associated with IL-6 (15% increase; 95% CI, 0.4%-27%; P = 0.006). Palmitic Acid 0-13 interleukin 6 Homo sapiens 165-169 25280420-10 2014 In particular, palmitic acid was associated with IL-6, and stearic acid was associated with CRP after multivariable adjustment. Palmitic Acid 15-28 interleukin 6 Homo sapiens 49-53 25045603-10 2014 RESULTS: Plasma interleukin-6 was elevated after intravenous administration of poly I:C in all monkeys. poly I:C 79-87 interleukin 6 Homo sapiens 16-29 24406841-7 2014 Treatment with ruxolitinib also resulted in the reduction of key cytokines (tumor necrosis factor alpha, interleukin-4 (IL-4), IL-6 and IL-8) and induction of interferon-gamma. ruxolitinib 15-26 interleukin 6 Homo sapiens 127-131 25176105-7 2014 CONCLUSION: Serum 25-(OH)D3 level is positively correlated with serum IL-6 level in KD children before IVIG treatment but not after the treatment,. Calcifediol 18-27 interleukin 6 Homo sapiens 70-74 24575826-7 2014 CONCLUSIONS: Vitamin E-coated dialyzer can reduce the oxidative stress and inflammation status reflected by the decreasing of serum TBARS, oxLDL, CRP, and IL-6 levels, and this new dialyzer does not affect the dialysis adequacy. Vitamin E 13-22 interleukin 6 Homo sapiens 155-159 24736562-4 2014 While PolyI:C induced maximal cytokine and chemokine production from both PHCEC (IFNgamma, CCL2, CCL3, and (CCL4), IL6, CXCL10, CCL5, TNFalpha) and PHKF (CCL2, IL-6, CXCL10, CCL5), only PHKF cytokines were inhibited by GCs. Poly I-C 6-13 interleukin 6 Homo sapiens 115-118 24363043-7 2014 IL-6 production by BSMC was induced by Fsk and select G protein-coupled receptor (GPCR) agonists, though IL-6 levels did not directly correlate with global cAMP levels. bsmc 19-23 interleukin 6 Homo sapiens 0-4 24548420-8 2014 In a multivariate linear regression analysis, cotinine concentrations had a weak inverse association with IL-4 and IL-6 (p=0.028 and p=0.06) which was not statistically significant when adjusted for multiple comparisons (modified Bonferroni, p>0.016). Cotinine 46-54 interleukin 6 Homo sapiens 115-119 24548420-10 2014 CONCLUSIONS: Among highly SHS exposed adolescents, cotinine levels had weak inverse association with IL-4 and IL-6, which did not achieve statistical significance. Cotinine 51-59 interleukin 6 Homo sapiens 110-114 24566440-6 2014 LOOH (p < 0.01), IL-6 (p < 0.05) and hsCRP (p < 0.05) responses to trials were lower in the MC group versus PLA. Methylcholanthrene 101-103 interleukin 6 Homo sapiens 20-24 25332774-10 2014 Respecting confounder hsCRP was associated with LVM (5.2 g/10 mg/L hsCRP, 95% CI 1.6 to 8.8), IVSD (0.2 mm/10 mg/L hsCRP, 95% CI 0 to 0.3) and PWD (0.2 mm/10 mg/L hsCRP, 95% CI 0.1 to 0.3) in women, while there were no relevant effects in analysis of IL-6 in both sexes. hscrp 22-27 interleukin 6 Homo sapiens 251-255 24128422-6 2014 LPS increased the concentrations of TNFalpha, IL-6, IL-8, IL-10, and HBD2 by factors of 30-, eight, three, three, and fivefold, respectively. lps 0-3 interleukin 6 Homo sapiens 46-50 25531978-7 2014 Both the mean blood IL-6 and lactate levels had significantly decreased to normal ranges after 72 h of AN69ST-CHDF. an69st-chdf 103-114 interleukin 6 Homo sapiens 20-24 25424939-5 2014 In addition thimerosal dampened their proinflammatory response, in particular the production of the Th1 polarizing cytokine IL-12, as well as TNF-alpha and IL-6. Thimerosal 12-22 interleukin 6 Homo sapiens 156-160 23994382-5 2014 RESULTS: PegIFNalpha induced a distinct and rapid up-regulation of IFN signaling pathway that coincided with increase detection of distinct serum cytokines/chemokines (IL-15, IL-6, and CXCL-10) and the up-regulation of the frequency of proliferating NK and activated total CD8+ T cells. pegifnalpha 9-20 interleukin 6 Homo sapiens 175-179 24063614-7 2014 The cumulative suppression of Interleukin-6 and Interleukin-10 levels induced by sucralose may contribute to the inability in mounting an effective humoral response when posed with an exogenous threat. trichlorosucrose 81-90 interleukin 6 Homo sapiens 30-43 25328518-5 2014 Mancozeb induced dose-dependent increases in lymphocyte proliferation, inhibition of production of TNFalpha and the TH2 cytokines IL-6 and IL-10, and an increase in IFNgamma (TH1 cytokine) production (at least 2-fold compared to control); mancozeb also induced inhibition of IL-4 (TH2) and stimulated IL-2 (TH1) production, albeit only in dose-related manners for each. mancozeb 0-8 interleukin 6 Homo sapiens 130-134 23869537-9 2013 IL-6 in DHM was 0.3% of the content found in MHM. dhm 8-11 interleukin 6 Homo sapiens 0-4 24048704-5 2013 Mechanistic focus on IL-6 revealed that erlotinib induced a time-dependent increase in IL-6 mRNA and protein expression. Erlotinib Hydrochloride 40-49 interleukin 6 Homo sapiens 21-25 24048704-5 2013 Mechanistic focus on IL-6 revealed that erlotinib induced a time-dependent increase in IL-6 mRNA and protein expression. Erlotinib Hydrochloride 40-49 interleukin 6 Homo sapiens 87-91 24048704-6 2013 Importantly, exogenous IL-6 protected HNSCC cells from erlotinib-induced cytotoxicity, whereas tocilizumab, an IL-6 receptor antagonist, sensitized cells to erlotinib in vitro and in vivo. Erlotinib Hydrochloride 55-64 interleukin 6 Homo sapiens 23-27 24107356-8 2013 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Vorinostat 17-21 interleukin 6 Homo sapiens 303-307 24107356-8 2013 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Vorinostat 23-33 interleukin 6 Homo sapiens 303-307 24107356-8 2013 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Panobinostat 40-46 interleukin 6 Homo sapiens 303-307 24107356-8 2013 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Panobinostat 48-60 interleukin 6 Homo sapiens 303-307 24257035-5 2013 Citalopram increased production of IL-1beta, IL-6, TNF-alpha and IL-22. Citalopram 0-10 interleukin 6 Homo sapiens 45-49 24241092-7 2013 Supplementation of vitamin E with and without ALA significantly reduced interleukin-6 concentration. Vitamin E 19-28 interleukin 6 Homo sapiens 72-85 23524525-9 2013 A significant decrease in leptin (-3.1 ng/ml) and interleukin-6 (-0.4 pg/ml) was found only with pioglitazone; a similar trend (-2.5 ng/ml and -0.3 pg/ml, respectively) was maintained after the addition of rosuvastatin.Rosuvastatin+pioglitazone decreased tumor necrosis factor-alpha (-0.3 ng/ml) and were superior to glibenclamide+rosuvastatin in reducing high-sensitivity C-reactive protein (-0.4 mg/l).Pioglitazone decreased ultrasound parameters, and the addition of rosuvastatin further decreased them both compared with randomization and glibenclamide. Pioglitazone 97-109 interleukin 6 Homo sapiens 50-63 23915387-8 2013 GW-0742 significantly suppressed IL-6 protein production, the expression of proliferating cell nuclear antigen in the neointima and enhanced CD31 expression. GW0742 0-7 interleukin 6 Homo sapiens 33-37 23895055-7 2013 Using HUVECs we demonstrated that tylophorine inhibited VEGF-stimulated inflammatory responses including IL-6, IL-8, TNF-alpha, IFN-gamma, MMP-2 and NO secretion. tylophorine 34-45 interleukin 6 Homo sapiens 105-109 23771534-11 2013 Inhibition of MIF by (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester (ISO-1), an inhibitor of MIF tautomerase activity, significantly enhanced the dexamethasone suppressive effect on IL-6 production. (s,r)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester 21-95 interleukin 6 Homo sapiens 210-214 22351517-8 2013 When applied alone, CpdA increased the epidermal thickness and keratinocyte proliferation as well as levels of c-jun, COX-2, IL-6, and IFN-gamma. CPDA 20-24 interleukin 6 Homo sapiens 125-129 23591198-0 2013 Serum levels of IL-6 and IL-1beta can predict the efficacy of gemcitabine in patients with advanced pancreatic cancer. gemcitabine 62-73 interleukin 6 Homo sapiens 16-20 23562757-6 2013 In contrast, as compared with control, the secretion of IL-12p40, IL-23 and IL-6 was lower from AEE-DCs and 2Ph-CDs and allogeneic CD4(+) T cells co-cultured with these DCs secreted lower levels of IFN-gamma and IL-10 but the same levels of IL-17. 2ph-cds 108-115 interleukin 6 Homo sapiens 76-80 23688750-9 2013 PC-CD cases showed a significantly higher expression rate of IL-6 than HV-CD cases (P = 0.001). pc-cd 0-5 interleukin 6 Homo sapiens 61-65 23688750-11 2013 Compared with HV-CD cases, much more PC-CD cases showed IL-6 positivity in endothelial cells (P = 0.008). pc-cd 37-42 interleukin 6 Homo sapiens 56-60 23436796-4 2013 Treatment with cisplatin or carboplatin increased the potency of tumor cell lines to induce IL-10-producing M2 macrophages, which displayed increased levels of activated STAT3 due to tumor-produced IL-6 as well as decreased levels of activated STAT1 and STAT6 related to the PGE(2) production of tumor cells. Carboplatin 28-39 interleukin 6 Homo sapiens 198-202 23219088-3 2013 Furthermore, pyruvate suppressed the UVB-induced mRNA expression of inflammatory mediators such as interleukin (IL)-1alpha, IL-1beta, IL-6 and cyclooxygenase-2 (Cox-2). Pyruvic Acid 13-21 interleukin 6 Homo sapiens 134-138 23219088-6 2013 UVB-induced production of IL-6 was inhibited by SB203580, a p38 MAPK inhibitor. SB 203580 48-56 interleukin 6 Homo sapiens 26-30 22571867-10 2013 Of four patients with paired data, three (including a responder to pranlukast) showed decreased pro-inflammatory cytokines (IL-1beta, IL-6, and TNFalpha), and four showed decreased sTNFR1, after pranlukast treatment, and only a responder had markedly decreased frequency of CD8+ T cells in CSF. pranlukast 67-77 interleukin 6 Homo sapiens 134-138 23439564-3 2013 PHF, DP and GA could significantly suppress the expression of allergic inflammatory cytokine IL-33-upregulated intercellular adhesion molecule (ICAM)-1, and the release of chemokines CCL2, CCL5, CXCL8 and inflammatory cytokine IL-6 from KU812 cells (all p < 0.05). dp 5-7 interleukin 6 Homo sapiens 227-231 23232207-8 2013 CAP-induced time dependent changes in the phosphorylation status of mitogen activated protein kinase (MAPK) signaling mediators that led to a 2.5-fold increase in IL-6 release after 24 h. This rise did not occur either in TRPV1 siRNA gene silenced cells or during exposure to SB203580 (10 muM), a selective p38 MAPK inhibitor. SB 203580 276-284 interleukin 6 Homo sapiens 163-167 22749216-5 2013 Simultaneous treatment of cells with DNA and dsRNA analog poly(I:C) leads to inhibition of poly(I:C)-activated secretion of IL-6 and IL-8. Poly I-C 58-66 interleukin 6 Homo sapiens 124-128 22749216-5 2013 Simultaneous treatment of cells with DNA and dsRNA analog poly(I:C) leads to inhibition of poly(I:C)-activated secretion of IL-6 and IL-8. Poly I-C 58-67 interleukin 6 Homo sapiens 124-128 22732733-8 2013 Time dependence of the production of IL-6 in the primary cell line showed that TfPLL conjugate enabled a gradual release of poly(I:C) and stronger activation of TLR3 receptor in comparison with poly(I:C) alone. Poly I-C 124-132 interleukin 6 Homo sapiens 37-41 24088253-4 2013 Furthermore, sesamin suppressed the constitutive and interleukin (IL)-6-induced signal transducer and activator of transcription 3 (STAT3) signalling pathway in HepG2 cells, leading to regulate the downstream genes, including p53, p21, cyclin proteins and the Bcl-2 protein family. sesamin 13-20 interleukin 6 Homo sapiens 53-71 23430672-11 2013 In the DEDG, significant negative correlations were detected between the Schirmer test and IL-1beta, IL6, IL8, and vascular endothelial growth factor levels, and between the fluorescein breakup time with IL6 and IL8 levels. Fluorescein 174-185 interleukin 6 Homo sapiens 204-207 23711857-9 2013 RESULTS: Alternaria and polyinosinic-polycytidylic acid (poly I:C) enhanced cell surface expression of MHC class II, CD40, CD80, CD86 and OX40L, and IL-6 production in a concentration-dependent manner. Poly I-C 24-55 interleukin 6 Homo sapiens 149-153 23711857-9 2013 RESULTS: Alternaria and polyinosinic-polycytidylic acid (poly I:C) enhanced cell surface expression of MHC class II, CD40, CD80, CD86 and OX40L, and IL-6 production in a concentration-dependent manner. Poly I-C 57-65 interleukin 6 Homo sapiens 149-153 23470566-6 2013 RESULTS: We found increased production of TNF-alpha, MCP-1, IL-6, and free glycerol, FFAs in the co-culture medium, and butyrate significantly reduced them. Butyrates 120-128 interleukin 6 Homo sapiens 60-64 24302816-7 2013 Furthermore, both NF- kappa B inhibitor Bay11-7085 and p38 inhibitor SB203580 significantly suppressed the enhanced production of IL-6 and MMPs induced by HMGB1-LPS. SB 203580 69-77 interleukin 6 Homo sapiens 130-134 23117195-5 2013 Combined with silicon nanowire (SiNW) transistors, a sensor with ultra high sensitivity for the detection of specific potential low abundance biomarkers has been achieved, which has been specifically used to detect interleukin-6 (IL-6) at extremely low concentrations. Silicon 14-21 interleukin 6 Homo sapiens 215-228 23117195-5 2013 Combined with silicon nanowire (SiNW) transistors, a sensor with ultra high sensitivity for the detection of specific potential low abundance biomarkers has been achieved, which has been specifically used to detect interleukin-6 (IL-6) at extremely low concentrations. Silicon 14-21 interleukin 6 Homo sapiens 230-234 22763947-4 2012 Our megakaryocytic culture conditions using the cytokines SCF, TPO, IL-9, and IL-6 include nicotinamide and Rho-associated kinase (ROCK) inhibitor Y27632 as contextual additives. Niacinamide 91-103 interleukin 6 Homo sapiens 78-82 22696056-0 2012 Vitiligo-inducing phenols activate the unfolded protein response in melanocytes resulting in upregulation of IL6 and IL8. Phenols 18-25 interleukin 6 Homo sapiens 109-112 22696056-9 2012 Co-treatment with XBP1 inhibitors reduced IL6 and IL8 production induced by phenols, while overexpression of XBP1 alone increased their expression. Phenols 76-83 interleukin 6 Homo sapiens 42-45 23069909-5 2012 report the upregulation of IL-6 and IL-8 after the activation of the unfolded protein response (UPR) following exposure of melanocytes to phenols. Phenols 138-145 interleukin 6 Homo sapiens 27-31 22365613-2 2012 Vitamin E and the carotenoids are two classes of dietary antioxidants with profound anti-inflammatory effects, and the goal of this study was to assess whether higher post-fracture concentrations of these antioxidants were associated with lower levels of interleukin 6 (IL-6) and the soluble receptor for tumor necrosis factor-alpha (sTNF-alphaR1), two common markers of inflammation. Vitamin E 0-9 interleukin 6 Homo sapiens 255-268 22365613-2 2012 Vitamin E and the carotenoids are two classes of dietary antioxidants with profound anti-inflammatory effects, and the goal of this study was to assess whether higher post-fracture concentrations of these antioxidants were associated with lower levels of interleukin 6 (IL-6) and the soluble receptor for tumor necrosis factor-alpha (sTNF-alphaR1), two common markers of inflammation. Vitamin E 0-9 interleukin 6 Homo sapiens 270-274 22381051-9 2012 The level of IL-6 at the end of surgery was lower for sevoflurane (69.5 [35.9-121.0] pg/mL) than propofol-remifentanil (128.2 [92.8-163.8] pg/mL, p = 0.03), but this difference was not maintained 24 hours after surgery. Propofol 97-105 interleukin 6 Homo sapiens 13-17 22722257-4 2012 RESULTS: Patients with PDAC had higher circulating levels of interleukin 6 (IL-6) than those of patients with pancreatitis or healthy individuals and higher levels of IL-10 and tumor necrosis factor alpha (TNF-alpha) compared with those of healthy individuals. pdac 23-27 interleukin 6 Homo sapiens 61-74 22722257-4 2012 RESULTS: Patients with PDAC had higher circulating levels of interleukin 6 (IL-6) than those of patients with pancreatitis or healthy individuals and higher levels of IL-10 and tumor necrosis factor alpha (TNF-alpha) compared with those of healthy individuals. pdac 23-27 interleukin 6 Homo sapiens 76-80 22722257-5 2012 In patients with PDAC, circulating IL-6, TNF-alpha, IL-1beta, and IL-10 correlated with serum concentrations of vascular endothelial growth factor and basic fibroblast growth factor; circulating IL-6, IL-1beta, and TNF-alpha correlated with carbohydrate 19-9; and IL-8, IL-10, and TNF-alpha correlated with CEA levels. pdac 17-21 interleukin 6 Homo sapiens 35-39 22213096-2 2012 In this study, we investigated IL-6-induced NED in two LNCaP sublines. ned 44-47 interleukin 6 Homo sapiens 31-35 22213096-4 2012 RESULTS: IL-6 did not induce NED in LNCaP-S17 cells, even though IL-6 induced NED in LNCaP-C3 cells. ned 78-81 interleukin 6 Homo sapiens 65-69 22489869-11 2012 The clinical significance of the higher postoperative mean serum IL-6 and IL-10 levels in the RA group remains to be clarified in a future study. Radium 94-96 interleukin 6 Homo sapiens 65-69 22575517-4 2012 High-glucose medium increased the intracellular reactive oxygen species levels in HMC-1 and LAD2 cells after 2 days of incubation; in HMC-1 cells, the expression levels of tumor necrosis factor (TNF) alpha, interleukin (IL)-1beta, IL-6, and IL-13 were increased significantly. high-glucose 0-12 interleukin 6 Homo sapiens 231-235 22273698-7 2012 Cucurbitacin I treatment alone increased pErk1/2 expression in wild-type and Pim-1-overexpressing cell lines and resulted in exaggerated Pim-1 kinase protein levels in control and IL-6-stimulated cells, suggesting that up-regulation of Pim-1 may be partially STAT3 independent. cucurbitacin I 0-14 interleukin 6 Homo sapiens 180-184 22471522-4 2012 Relative to IR alone, myeloma cells treated with IL-6 plus IR demonstrated reduced annexin/propidium iodide staining, caspase 3 activation, PARP [poly(ADP-ribose) polymerase] cleavage and mitochondrial membrane depolarization with increased clonogenic survival. Propidium 91-107 interleukin 6 Homo sapiens 49-53 21938724-0 2012 Imatinib treatment inhibit IL-6, IL-8, NF-KB and AP-1 production and modulate intracellular calcium in CML patients. Imatinib Mesylate 0-8 interleukin 6 Homo sapiens 27-31 21938724-7 2012 Our results demonstrated a significant down-regulation in IL-6 and IL-8 release as well as NF-kB and AP-1 activation in lymphomonocytes from Imatinib-treated patients, compared to samples from untreated patients. Imatinib Mesylate 141-149 interleukin 6 Homo sapiens 58-62 21938724-9 2012 The results of this study show that measurements of NF-kB, AP-1, IL-6, IL-8, and intracellular calcium in CML patients treated with Imatinib may give important information to the hematologist on diagnostic criteria and are highly predictive in patients with newly diagnosed CML. Imatinib Mesylate 132-140 interleukin 6 Homo sapiens 65-69 22334023-6 2012 Secretory NAP was expressed at high levels by infected tumor cells and increased tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and IL-12/23 cytokine concentrations were detected in the pleural effusion. nap 10-13 interleukin 6 Homo sapiens 137-141 22726350-3 2012 ST, rosmarinic acid, pulegone, and 2alpha,3alpha,24-thrihydrooxylen-12en-28oic acid treatment of HMC-1 cells led to significant suppression of pro-inflammatory cytokines (IL-6, IL-8, and TNF-alpha) in a dose dependent manner. 24-thrihydrooxylen-12en-28oic acid 49-83 interleukin 6 Homo sapiens 171-175 22379967-10 2012 Finally, 5,7-DMF reduced IkappaBalpha phosphorylation, blocked NF-kappaB p65 nuclear translocation, strongly suppressed proinflammatory cytokines such as interleukin-6 (IL-6) and IL-8. 5,7-dimethoxyflavone 9-16 interleukin 6 Homo sapiens 154-167 22379967-10 2012 Finally, 5,7-DMF reduced IkappaBalpha phosphorylation, blocked NF-kappaB p65 nuclear translocation, strongly suppressed proinflammatory cytokines such as interleukin-6 (IL-6) and IL-8. 5,7-dimethoxyflavone 9-16 interleukin 6 Homo sapiens 169-173 22070917-9 2012 The stimulation of TLR3-expressing OC2 cells with poly I:C caused the phosphorylation of IFN regulatory factor 3 and IkappaB and sequentially induced the secretion of interleukin-6 and chemokine (C-C motif) ligand 5 (CCL5) in a dose- and time-dependent manner. Poly I-C 50-58 interleukin 6 Homo sapiens 167-215 21161531-6 2012 Furthermore, IL-6 and IL-8 expression was quantified by real-time polymerase chain reaction (RT-PCR) and ELISAs from cells which were exposed to SB203580, U0126 and NaHS and stimulated by IL-1beta. SB 203580 145-153 interleukin 6 Homo sapiens 13-17 21979104-10 2012 Moreover, IL-6 ELF level in the dependent lung was significantly higher in the propofol group than in the sevoflurane group after OLV (P < 0.001). Propofol 79-87 interleukin 6 Homo sapiens 10-14 22870491-9 2012 However, elevated levels of serum CRP and synovial fluid IL-6 (r = 0.034; p < 0.05) were decreased insignificantly (p < 0.1) after vitamin E supplementation in knee OA patients. Vitamin E 137-146 interleukin 6 Homo sapiens 57-61 22293241-4 2012 The present study aimed to investigate the acute and chronic effects of a 2 x 180 mg per day dose of eicosapentaenoic acid (EPA) on interleukin-6 (IL-6) mediated inflammatory response and symptoms associated with DOMS. DOMS 213-217 interleukin 6 Homo sapiens 147-151 22269218-9 2012 It is plausible that the angiogenic effect of gamma tocopherol in placental vascular network is exerted via an alternate path by enhancing IL-6 and IL-8. gamma-Tocopherol 46-62 interleukin 6 Homo sapiens 139-143 22239975-4 2012 In this study we show in human PBMCs that LPS stimulated proinflammatory cytokine release (CXCL8 and IL6) was inhibited by approximately 50% by the broad specificity phosphatidylinositol 3-kinase (PI3K) inhibitor, wortmannin. Wortmannin 214-224 interleukin 6 Homo sapiens 101-104 22977658-5 2012 Moreover, we found that the proteasome inhibitor MG132 could inhibit IL-6/TGF-beta-mediated downregulation of FOXP3 protein, which reveals a potential pathway for modulating Treg activity by preventing FOXP3 degradation during inflammation. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 49-54 interleukin 6 Homo sapiens 69-73 21881585-7 2012 Taken together, our data strongly suggest that DHT-inducible IL-6 inhibits hair growth as a paracrine mediator from the DP. dp 120-122 interleukin 6 Homo sapiens 61-65 21995322-11 2011 In preclinical and Phase I and II trials ALD518 targeting IL-6 appears well tolerated and ameliorates NSCLC-related anemia and cachexia. ald518 41-47 interleukin 6 Homo sapiens 58-62 21771657-3 2011 In this paper, we discuss the evidence that doxycycline and related non-antibiotic chemically modified tetracyclines (e.g., CMT-3) can effectively reduce cytokine (TNF-alpha, IL-6, and MCP-1) production by human mononuclear inflammatory cells when stimulated either by endotoxin (LPS) or by a complex of C-reactive protein/oxidized LDL cholesterol relevant to the pathogenesis of periodontal disease and ASCVD, respectively. Tetracyclines 103-116 interleukin 6 Homo sapiens 175-179 21930594-5 2011 Moreover, we found that loratadine and chlorpromazine, histamine 1 receptor (H1R) antagonists, more effectively impair the production of LPS-induced IL-6 than that of other inflammatory cytokines in Ahr(-/-) macrophages. Chlorpromazine 39-53 interleukin 6 Homo sapiens 149-153 21922361-9 2011 Serum levels of tumor necrosis factor-alpha, interleukin-6, and high-mobility group box 1 were higher in the CT group than in the IIT group. ct 109-111 interleukin 6 Homo sapiens 45-58 21609320-10 2011 Finally, we found that mutation of the GATA-binding site impaired the interleukin-6 induction of hepcidin gene expression, but did not prevent the bone morphogenetic protein-6 response. gata 39-43 interleukin 6 Homo sapiens 70-83 21439397-1 2011 OBJECTIVE: This study aimed to investigate the effect of betamethasone treatment on the endocervical concentration of IL-1beta, IL-4, IL-6, and TNF-alpha in preterm labor patients. Betamethasone 57-70 interleukin 6 Homo sapiens 134-138 21111593-7 2011 Whereas stigmasterol blunted aggregated LDL (agLDL) induced increases in tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-1beta secretion, sitosterol exacerbated these effects. Stigmasterol 8-20 interleukin 6 Homo sapiens 108-126 21508145-8 2011 Levothyroxine reduced monocyte release of TNF-alpha, IL-1beta, IL-6, and monocyte chemoattractant protein-1, whereas selenomethionine inhibited lymphocyte release of IL-2, interferon-gamma, and TNF-alpha, which was accompanied by a reduction in plasma CRP levels. Thyroxine 0-13 interleukin 6 Homo sapiens 63-67 21345936-6 2011 Polysulphated cyclodextrins MA-CDPS, HP-CDPS, CE-CDPS and CDPS at 5 microg/ml concentrations, on the other hand, significantly induced aggrecan production and repressed IL-6 release by the chondrocytes in culture. hp-cdps 37-44 interleukin 6 Homo sapiens 169-173 21605007-7 2011 In contrast, the non-purine metabolite taurine correlated with baseline neutrophil counts (r = 0.56) and IL-6 (r = 0.53) and was elevated post-exposure in both atopic cohorts. Taurine 39-46 interleukin 6 Homo sapiens 105-109 22468044-7 2011 Future studies may focus on the effect of a-tocopheryl acetate or the phosphate form of Vitamin-E, recently proposed to be the more active form on other inflammatory markers like IL-6, an important stimuli of P-selectin release in pre-eclampsia. Vitamin E 88-97 interleukin 6 Homo sapiens 179-183 21322102-5 2011 In the present study, we studied the effects of dec-ODN delivered through biodegradable and respirable poly(D,L-lactide-co-glycolide) large porous particles (LPP) on IL-6 and IL-8 mRNA expression as well as NF-kappaB/DNA binding activity in cystic fibrosis cells stimulated with lipopolysaccharide (LPS) from Pseudomonas aeruginosa. Polylactic Acid-Polyglycolic Acid Copolymer 103-132 interleukin 6 Homo sapiens 166-170 21673512-3 2011 The involvement of other relevant components of the saponin-related signaling routes, such as the Tumor Necrosis Factor(TNF)-alpha, the interleukin(IL)-6 and the Nuclear Transcription Factor-kB (NF-kappaB), has been highlighted in animal cells. Saponins 52-59 interleukin 6 Homo sapiens 136-153 20931350-6 2011 Furthermore, replacement of a rare leucine codon TTA with CTG in SP (CagA) enhanced IL-6 production. ctg 58-61 interleukin 6 Homo sapiens 84-88 21176394-7 2011 The IL-6 secretory pathway of MSCs was inhibited by SB203580, an inhibitor of p38 MAPK or siRNA against p38 MAPK, suggesting IL-6 secretion by MSCs is mediated through the activation of p38 MAPK. SB 203580 52-60 interleukin 6 Homo sapiens 125-129 22194647-13 2011 Mapracorat inhibited eosinophil migration and IL-8 release from eosinophils or the release of IL-6, IL-8, CCL5/RANTES, and TNF-alpha from a human mast cell line with equal potency as dexamethasone, whereas it was clearly less potent than this glucocorticoid in inducing annexin I and CXCR4 expression on the human eosinophil surface; this was taken as a possible sign of glucocorticoid-dependent transactivation. R-1,1,1-trifluoro-4-(5-fluoro-2,3-dihydrobenzofuran-7-yl)-4-methyl-2-(((2-methyl-5-quinolyl)amino)methyl)pentan-2-ol 0-10 interleukin 6 Homo sapiens 94-98 22219632-8 2011 CONCLUSIONS: This study showed that CYS decreased PBMC proliferation, IL-6 and TGF-beta1 levels via ROS formation. Cysteamine 36-39 interleukin 6 Homo sapiens 70-74 22164217-8 2011 The results show that Annexin A1 can negatively regulate phosphorylation of p38 and release of IL-1beta, IL-6 and TNF-alpha in THP-1 cells following propofol intervention and lipopolysaccharide (LPS) stimulation. Propofol 149-157 interleukin 6 Homo sapiens 105-109 22164217-9 2011 Our results clearly indicate that propofol can up-regulate Annexin A1 to inhibit the phosphorylation level of p38 and release of IL-1beta, IL-6 and TNF-alpha, so as to inhibit inflammatory response. Propofol 34-42 interleukin 6 Homo sapiens 139-143 21755010-11 2011 6-OAP overcame the protective effects of IL-6 and IGF-I on MM cells through inhibition of Jak2/Stat3 and Akt, respectively. 6-O-angeloylprenolin 0-5 interleukin 6 Homo sapiens 41-45 20384691-5 2010 Peak prilocaine serum concentration was reached 4 h (0.72 +- 0.07 mug/mL), the maximum concentration of MHb (7.43 +- 0.87%) and IL-6 (28.4 +- 4.1 U/L) 12 h after TLA application. Prilocaine 5-15 interleukin 6 Homo sapiens 128-132 20384691-8 2010 CONCLUSIONS: This clinical study shows for the first time that a high prilocaine serum concentration leads in vivo to elevated systemic levels of IL-6 but not of IL-8 and TNF-alpha because of initial high MHb levels. Prilocaine 70-80 interleukin 6 Homo sapiens 146-150 20725805-6 2010 In all compartments, IL-6 levels appeared to be higher in symptomatic patients, accompanied also by a higher ECF lactate-pyruvate ratio (P = 0.04). Pyruvic Acid 121-129 interleukin 6 Homo sapiens 21-25 20637814-9 2010 The production of inflammatory cytokine, IL-6 from macrophages was significantly reduced by Ad/chitosan-PEG-FA nanocomplexes, implying the potential for use in systemic administration. peg-fa 104-110 interleukin 6 Homo sapiens 41-45 20657019-1 2010 BACKGROUND: The authors previously reported that human ocular surface epithelium expressed TLR3 and that its ligand polyI:C stimulated the secretion of IL-6, IL-8 and IFN-beta. Poly I-C 116-123 interleukin 6 Homo sapiens 152-156 20652679-2 2010 METHODS: IL-6-stimulated expression of the genes for acute-phase response markers serum amyloid A (SAA1, SAA2) and haptoglobin (HP) in the human hepatocarcinoma cell line HepG2 were quantified after modulation of AMPK activity by pharmacological agonists (5-amino-4-imidazole-carboxamideriboside [AICAR], metformin) or by using small interfering (si) RNA transfection. 5-amino-4-imidazole-carboxamideriboside 256-295 interleukin 6 Homo sapiens 9-13 20881254-5 2010 CpdA, like IL-6, but unlike Dex, increases GR binding and decreases the metabolic enzymes, tyrosine aminotransferase, phosphoenolpyruvate carboxykinase, and gamma glutamyltransferase, at protein or mRNA level. CPDA 0-4 interleukin 6 Homo sapiens 11-15 20693312-7 2010 After 48-h exposure of cells to DXM or BTM, IL-6 caused a significantly greater increase in SP-B mRNA levels (28.1-fold) than IL-6 or glucocorticoids alone. Betamethasone 39-42 interleukin 6 Homo sapiens 44-48 20693312-9 2010 Both DXM and BTM could potentiate IL-6-induced phosphorylation of STAT3. Betamethasone 13-16 interleukin 6 Homo sapiens 34-38 20878012-10 2010 A positive dose-response curve for IL-6 after stimulation with amoxicillin and penicillin was observed for pDC, but not for mDC or BDC suspension. BDC 131-134 interleukin 6 Homo sapiens 35-39 20831680-15 2010 Interleukin-6 and tumour necrosis factor-alpha decreased after full treatment in the pioglitazone group relative to the end of titration period. Pioglitazone 85-97 interleukin 6 Homo sapiens 0-46 20711637-6 2010 MTT analysis and cell cycle analysis indicated that chitosan-gelatin blends promoted the proliferation of HSF. monooxyethylene trimethylolpropane tristearate 0-3 interleukin 6 Homo sapiens 106-109 23555753-5 2013 Moreover, TSA also enhanced palmitic acid-induced IL-6 production and the expression of inflammatory genes induced by LPS in preadipocytes. Palmitic Acid 28-41 interleukin 6 Homo sapiens 50-54 22048871-9 2012 DNA-binding ELISA experiments revealed that (+)-episesamin treated HCC cells showed a suppressed basal and TNFalpha-induced activation of NF-kappaB and a subsequent suppression of TNFalpha- and LPS-induced IL-6 production. sesamin 44-58 interleukin 6 Homo sapiens 206-210 22048871-11 2012 Our findings show that anti-neoplastic effects of (+)-episesamin are mediated via suppressed activation of NF-kappaB which entails a decreased release of pro-inflammatory IL-6. sesamin 50-64 interleukin 6 Homo sapiens 171-175 23012246-7 2012 RSK2(Ser227) inhibition resulting from BI-D1870 treatment restored lenalidomide-induced direct cytotoxicity of myeloma cells from interleukin-6-mediated cell protection, showed no cross-resistance to bortezomib, and exerted additive/synergistic antiproliferative effects in conjunction with the mTOR, histone deacetylase, and BH3-mimicking BCL2/BCLX(L) inhibitors. Lenalidomide 67-79 interleukin 6 Homo sapiens 130-143 23285696-0 2012 The effect of phytic acid on the expression of NF-kappaB, IL-6 and IL-8 in IL-1beta-stimulated human colonic epithelial cells. Phytic Acid 14-25 interleukin 6 Homo sapiens 58-62 23285696-7 2012 The aim of this study was to analyze the effect of IP6 on the expression of IL-6 and IL-8 as well as p50 and p65 subunits of NF-kappaB and its inhibitor IkappaBalpha in Caco-2 cells stimulated with IL-1beta. Phytic Acid 51-54 interleukin 6 Homo sapiens 76-80 23285696-10 2012 Treatment of cells with IP6 resulted in a marked decrease in both IL-6 (at 3 and 6 h) and IL-8 expression (3 h). Phytic Acid 24-27 interleukin 6 Homo sapiens 66-70 23285696-11 2012 The results of these studies suggest that IP6 may exert immunoregulatory effects on intestinal epithelium by influencing transcriptional activity of genes encoding p50 subunit of NF-kappaB, its inhibitor IkappaBalpha and proinflammatory cytokines IL-6 and IL-8. Phytic Acid 42-45 interleukin 6 Homo sapiens 247-251 22961265-9 2012 NF-kappaB and ERK1/2 inhibition in l-NAME-treated animals blunted the l-NAME-induced cytokine upregulation except IL-6, whereas P38 inhibition blunted all (including IL-6) cytokine upregulation. NG-Nitroarginine Methyl Ester 70-76 interleukin 6 Homo sapiens 166-170 23036591-16 2012 Exposure to BaP affected mo-DC function as demonstrated by decreased IL6 expression induced by PolyI:C, without affecting indoleamine 2,3 dioxygenase (IDO)1 expression. Poly I-C 95-102 interleukin 6 Homo sapiens 69-72 22739025-5 2012 Importantly, methylation of the SOCS3 promotor appears to constitute an important regulatory mechanism for colonic SOCS3 expression as SOCS3 methylation status in CRC cells correlates with a disability to upregulate SOCS3 upon IL-6 stimulation, whereas forced demethylation using 5-aza-2"-deoxycytidine restores SOCS3 expression and inhibits IL-6-induced p-signal transducer and activator of transcription 3 activation and proliferation. Decitabine 280-302 interleukin 6 Homo sapiens 227-231 22884781-5 2012 RESULTS: The addition of Th2 cytokines (IL-4/IL-6) at a concentration of 10nM resulted in a marked decrease in SC ceramide levels. Ceramides 114-122 interleukin 6 Homo sapiens 45-49 21979577-8 2012 SB203580 inhibited ATP-induced TNF-alpha, IL-6, and NO production. SB 203580 0-8 interleukin 6 Homo sapiens 42-46 22449852-4 2012 The CaSR activation by the calcimimatic cinacalcet (5muM) in adipose tissue and in vitro cultured LS14 adipose cells elicited an elevation in the expression of the proinflammatory cytokines IL6, IL1beta, TNFalpha, and the chemoattractant CCL2. Cinacalcet 40-50 interleukin 6 Homo sapiens 190-193 22561747-5 2012 Importantly, pretreatment with HIF-1alpha siRNA, anti-IL-6 antibodies, STAT3 siRNA, and S100A4 siRNA, significantly attenuated the proliferation of PASMCs exposure to hypoxia. pasmcs 148-154 interleukin 6 Homo sapiens 54-58 22577802-8 2012 Imiquimod induced IL-6 and IL-8 production in OSCC cells, suggesting the functional expression of TLR7. Imiquimod 0-9 interleukin 6 Homo sapiens 18-22 22592163-11 2012 Two hours after LPS stimulation, cells treated with sanguinarine decreased the IL-6 mRNA level by a factor of 3.9 (p<0.001) compared with cells treated with the vehicle. sanguinarine 52-64 interleukin 6 Homo sapiens 79-83 22592163-13 2012 Sanguinarine decreased gene expression of CCL-2 and IL-6 more than chelerythrine and its effect was quite similar to prednisone. sanguinarine 0-12 interleukin 6 Homo sapiens 52-56 22434859-2 2012 Compound IQ-1 (11H-indeno[1,2-b]quinoxalin-11-one oxime) was found to be a potent, noncytotoxic inhibitor of pro-inflammatory cytokine [interleukin (IL)-1alpha, IL-1beta, IL-6, IL-10, tumor necrosis factor (TNF)-alpha, interferon-gamma, and granulocyte-macrophage colony-stimulating factor] and nitric oxide production by human and murine monocyte/macrophages. 11H-indeno(1,2-b)quinoxalin-11-one oxime 15-55 interleukin 6 Homo sapiens 171-175 22471285-5 2012 Interleukin (IL)-6 and IL-8 mRNA expression and protein secretion in LPS-stimulated cells were inhibited significantly by the lipophilic statin pitavastatin and the hydrophilic statin pravastatin. pitavastatin 144-156 interleukin 6 Homo sapiens 0-18 22377670-1 2012 A set of 8-methylene-, 8-methyl-, and 8-methyl-9-dihydro-oleandomycin derivatives having different combinations of stereochemistries at positions C-8 and/or C-9 have been prepared in a chemoselective and stereoselective manner and tested in vitro for antibacterial activity and inhibition of IL-6 production. 8-methylene-, 8-methyl-, and 8-methyl-9-dihydro-oleandomycin 9-69 interleukin 6 Homo sapiens 292-296 22227206-8 2012 HPAH PASMCs exhibited enhanced IL-6 and IL-8 induction by TGF-beta1, an effect reversed by NF-kappaB inhibition. pasmcs 5-11 interleukin 6 Homo sapiens 31-35 22227206-9 2012 Moreover, neutralizing antibodies to IL-6 or IL-8 restored the antiproliferative effect of TGF-beta1 in HPAH PASMCs. pasmcs 109-115 interleukin 6 Homo sapiens 37-41 21520044-7 2012 In addition, the pretreatment of LLL12 blocked the promotion of the cell proliferation and resistance to lenalidomide by IL-6. Lenalidomide 105-117 interleukin 6 Homo sapiens 121-125 22238384-10 2012 Finally, in particular imatinib mesylate and PDGF-BB-neutralizing antibodies reduced IL-6 and hyaluronan production by whole orbital tissue cultures from GO patients. Imatinib Mesylate 23-40 interleukin 6 Homo sapiens 85-89 21818627-7 2012 Akt and NF-kappaB related inflammatory cytokine IL-1alpha, and IL-6 and the chemokine IL-8 were upregulated in treated cells at 6 and 24 h. The calpain inhibitor leupeptin limited Akt phosphorylation to Ser(473) and reduced release of IL-1alpha, IL-6, and IL-8, indicating that calpain or similar protease(s) are involved in PM-induced activation of Akt and subsequent release of inflammatory cytokines. leupeptin 162-171 interleukin 6 Homo sapiens 63-67 21818627-7 2012 Akt and NF-kappaB related inflammatory cytokine IL-1alpha, and IL-6 and the chemokine IL-8 were upregulated in treated cells at 6 and 24 h. The calpain inhibitor leupeptin limited Akt phosphorylation to Ser(473) and reduced release of IL-1alpha, IL-6, and IL-8, indicating that calpain or similar protease(s) are involved in PM-induced activation of Akt and subsequent release of inflammatory cytokines. leupeptin 162-171 interleukin 6 Homo sapiens 246-250 22182640-4 2012 The anthocyanin-rich extract was added to the cells later and subsequently, the supernatant of each cell culture was analysed for the production of tumour necrosis factor-alpha (TNF-alpha), interleukin 1 (IL-1), interleukin 6 (IL-6), nitric oxide, and catalase activity as indices for the activation of macrophages. Anthocyanins 4-15 interleukin 6 Homo sapiens 212-225 22182640-4 2012 The anthocyanin-rich extract was added to the cells later and subsequently, the supernatant of each cell culture was analysed for the production of tumour necrosis factor-alpha (TNF-alpha), interleukin 1 (IL-1), interleukin 6 (IL-6), nitric oxide, and catalase activity as indices for the activation of macrophages. Anthocyanins 4-15 interleukin 6 Homo sapiens 227-231 22791168-4 2012 Pre-treatment of homoplantaginin on human umbilical vein endothelial cells (HUVECs) significantly inhibited PA induced tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) mRNA expression, and inhibitory kappaB kinase beta (IKKbeta) and nuclear factor-kappaB (NF-kappaB) p65 phosphorylation. Palmitic Acid 108-110 interleukin 6 Homo sapiens 164-177 22791168-4 2012 Pre-treatment of homoplantaginin on human umbilical vein endothelial cells (HUVECs) significantly inhibited PA induced tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) mRNA expression, and inhibitory kappaB kinase beta (IKKbeta) and nuclear factor-kappaB (NF-kappaB) p65 phosphorylation. Palmitic Acid 108-110 interleukin 6 Homo sapiens 179-183 22344368-9 2012 CONCLUSION: Administration of the complete cycle of betamethasone to the mother had a suppressive effect on baseline ROI and IL-6 production in very low birth weight preterm newborn infants. Betamethasone 52-65 interleukin 6 Homo sapiens 125-129 22157665-5 2012 The CGCG compared to the PGCG showed significantly increased expression of TNF-alpha and IL-6 and decreased expression of IL-1beta by the spindle-shaped cells and increased expression of IL-1beta by the MGCs. pgcg 25-29 interleukin 6 Homo sapiens 89-93 22157665-7 2012 CONCLUSIONS: The proinflammatory cytokines TNF-alpha, IL-6 and IL-1beta seem to be involved in the growth process of PGCG and CGCG of the jaws. pgcg 117-121 interleukin 6 Homo sapiens 54-58 22420547-7 2012 A decrease in Il-6 level after application of Cisplatin and Methotrexate and a 5-10 fold increase in the level of Il-6 after application of Etoposide, Carboplatin, Cytarabine, and Gemcitabine were registered in the medium with ganglioneuroblastoma. Carboplatin 151-162 interleukin 6 Homo sapiens 114-118 20379953-2 2010 We found that two diterpenoids, kansuinine A and B, from E. KANSUI have an inhibitory effect on IL-6-induced Stat3 activation by activating ERK1/2. Diterpenes 18-30 interleukin 6 Homo sapiens 96-100 20571496-6 2010 RESULTS: In the group receiving vitamin B(6), plasma IL-6 and TNF-alpha levels significantly decreased at week 12. Niacinamide 32-41 interleukin 6 Homo sapiens 53-57 20571496-9 2010 CONCLUSIONS: A large dose of vitamin B(6) supplementation (100 mg/day) suppressed pro-inflammatory cytokines (that is, IL-6 and TNF-alpha) in patients with RA. Niacinamide 29-38 interleukin 6 Homo sapiens 119-123 20511231-6 2010 Here, we demonstrate that ligand-activated AHR is involved in priming the IL6 promoter through binding to nonconsensus dioxin response elements located upstream of the IL6 start site. Dioxins 119-125 interleukin 6 Homo sapiens 74-77 20511231-6 2010 Here, we demonstrate that ligand-activated AHR is involved in priming the IL6 promoter through binding to nonconsensus dioxin response elements located upstream of the IL6 start site. Dioxins 119-125 interleukin 6 Homo sapiens 168-171 20421217-8 2010 In addition, MS-275 and SAHA suppressed lipopolysaccharide (LPS)-induced NF-kappaB p65 nuclear accumulation, IL-6, IL-18 and nitric oxide (NO) secretion as well as down-regulated pro-angiogenic VEGF and MMP-2 and MMP-9 production in E11 cells at sub-micromolar levels. Vorinostat 24-28 interleukin 6 Homo sapiens 109-113 22420547-7 2012 A decrease in Il-6 level after application of Cisplatin and Methotrexate and a 5-10 fold increase in the level of Il-6 after application of Etoposide, Carboplatin, Cytarabine, and Gemcitabine were registered in the medium with ganglioneuroblastoma. gemcitabine 180-191 interleukin 6 Homo sapiens 114-118 2541694-3 1989 Interleukin-6 increased ALA synthase activity only slightly, but it substantially potentiated the induction of ALA synthase by Me2SO. me2so 127-132 interleukin 6 Homo sapiens 0-13 23051896-10 2012 The dopamine-induced IL-6 secretion was partially reduced by sulpiride and abrogated by propranolol. Propranolol 88-99 interleukin 6 Homo sapiens 21-25 22042237-6 2011 Finally, several in vitro studies have focused on the hypothesis that CS may reduce inflammatory processes by acting on the nuclear translocation of NF-kappaB, which is closely associated with the blood biomarkers of inflammation, primarily IL-1, IL-6 and C-reactive protein. Chondroitin Sulfates 70-72 interleukin 6 Homo sapiens 247-251 22019436-11 2011 The more benign illness and good prognosis of patients with pmSAH or non-pmSAH in contrast to patients with aSAH is reflected by the lower concentrations of IL-6. asah 108-112 interleukin 6 Homo sapiens 157-161 20181940-0 2010 Elevated CO2 selectively inhibits interleukin-6 and tumor necrosis factor expression and decreases phagocytosis in the macrophage. N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide 9-12 interleukin 6 Homo sapiens 34-47 20164300-0 2010 Butrin, isobutrin, and butein from medicinal plant Butea monosperma selectively inhibit nuclear factor-kappaB in activated human mast cells: suppression of tumor necrosis factor-alpha, interleukin (IL)-6, and IL-8. butrin 0-6 interleukin 6 Homo sapiens 185-203 20164300-0 2010 Butrin, isobutrin, and butein from medicinal plant Butea monosperma selectively inhibit nuclear factor-kappaB in activated human mast cells: suppression of tumor necrosis factor-alpha, interleukin (IL)-6, and IL-8. butein 23-29 interleukin 6 Homo sapiens 185-203 20164300-5 2010 Our results showed that butrin, isobutrin, and butein significantly reduced the phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced inflammatory gene expression and production of TNF-alpha, IL-6, and IL-8 in HMC-1 cells by inhibiting the activation of NF-kappaB. butrin 24-30 interleukin 6 Homo sapiens 207-211 20164300-5 2010 Our results showed that butrin, isobutrin, and butein significantly reduced the phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced inflammatory gene expression and production of TNF-alpha, IL-6, and IL-8 in HMC-1 cells by inhibiting the activation of NF-kappaB. butein 47-53 interleukin 6 Homo sapiens 207-211 21414766-5 2011 Nicotinamide treatment resulted in a significant reduction of basal and/or LPS-stimulated release and gene expression of the pro-inflammatory cytokines TNF-alpha, IL-6 and the chemokine IL-8, and the release of the prostaglandins PGE(2) and PGF(2)alpha and cyclooxygenase (COX)-2 mRNA expression. Niacinamide 0-12 interleukin 6 Homo sapiens 163-167 3220517-8 1988 Alkylation of HSF-PLA2 with p-bromophenacyl bromide concomitantly inhibited both enzyme and edema-inducing activity. 4-bromophenacyl bromide 28-51 interleukin 6 Homo sapiens 14-17 21819545-9 2011 CRP and IL-6 decreased with the HP diet. Hematoporphyrins 32-34 interleukin 6 Homo sapiens 8-12 20061317-11 2010 Multivariate analysis showed that MTAC(cr) is independently associated with dialysate IL-6 and serum albumin. Tetradecyltrimethylammonium chloride 34-38 interleukin 6 Homo sapiens 86-90 3062144-5 1988 IL-1, TNF alpha and IL-6 also affect changes in metabolism by changing levels of circulating insulin, glucagon and corticosterone. Corticosterone 115-129 interleukin 6 Homo sapiens 20-24 19844754-6 2010 Moreover, the levels of BDNF and IL-6 were lower in PD patients with MD compared with patients with solely MD after treatment with citalopram. Citalopram 131-141 interleukin 6 Homo sapiens 33-37 2851586-7 1988 As this fused protein had a Phe-Arg-Ala sequence at the junction of hIL-2 and BSF-2, it was possible to process mature BSF-2 from the fused BSF-2 by treatment with kallikrein and aminopeptidase P. From 1 liter of E. coli culture, 45 mg of mature BSF-2 was purified; it had a relative biological activity equal to that of natural BSF-2 purified from T cells. Phenylalanine 28-31 interleukin 6 Homo sapiens 119-124 21410593-7 2011 On the other hand, the KDG showed high CRP (89.7 +- 55.6 mg/l) and high IL-6 (242.2 +- 243.5 pg/ml), and CRP (r = 0.60, P < 0.0001) and IL-6 (r = 0.78, P < 0.0001) significantly correlated with log (BNP). 2-keto-3-deoxygluconate 23-26 interleukin 6 Homo sapiens 72-76 21410593-7 2011 On the other hand, the KDG showed high CRP (89.7 +- 55.6 mg/l) and high IL-6 (242.2 +- 243.5 pg/ml), and CRP (r = 0.60, P < 0.0001) and IL-6 (r = 0.78, P < 0.0001) significantly correlated with log (BNP). 2-keto-3-deoxygluconate 23-26 interleukin 6 Homo sapiens 139-143 3108877-3 1987 The synthetic diacylglycerols 1,2-dioctanoylglycerol (diC8) and 1-oleoyl-2-acetylglycerol strongly enhanced IFN-beta 2, but not IFN-beta 1, gene expression in human fibroblasts (FS-4 strain). 1,2-dioctanoylglycerol 30-52 interleukin 6 Homo sapiens 108-118 20354000-9 2010 Expression of a subset of these genes was downregulated by IL-6, an effect that was prevented by preincubation with 5-azadeoxycytidine, a DNMT1 inhibitor. Decitabine 116-134 interleukin 6 Homo sapiens 59-63 3108877-3 1987 The synthetic diacylglycerols 1,2-dioctanoylglycerol (diC8) and 1-oleoyl-2-acetylglycerol strongly enhanced IFN-beta 2, but not IFN-beta 1, gene expression in human fibroblasts (FS-4 strain). 1,2-dioctanoylglycerol 54-58 interleukin 6 Homo sapiens 108-118 20354000-10 2010 Anchorage-independent growth and migration of colon cancer cells was also increased by IL-6 in a 5-azadeoxycytidine-sensitive manner. Decitabine 97-115 interleukin 6 Homo sapiens 87-91 21638037-5 2011 After CPB, propofol significantly suppressed the increase of the serum lactate dehydrogenase (LDH), creatine phosphokinase (CK), and interleukin-6 (IL-6) levels and the decrease of the serum superoxide dismutase (SOD) level. Propofol 11-19 interleukin 6 Homo sapiens 133-146 21638037-5 2011 After CPB, propofol significantly suppressed the increase of the serum lactate dehydrogenase (LDH), creatine phosphokinase (CK), and interleukin-6 (IL-6) levels and the decrease of the serum superoxide dismutase (SOD) level. Propofol 11-19 interleukin 6 Homo sapiens 148-152 3108877-3 1987 The synthetic diacylglycerols 1,2-dioctanoylglycerol (diC8) and 1-oleoyl-2-acetylglycerol strongly enhanced IFN-beta 2, but not IFN-beta 1, gene expression in human fibroblasts (FS-4 strain). 1-oleoyl-2-acetylglycerol 64-89 interleukin 6 Homo sapiens 108-118 3108877-7 1987 diC8 was found to protect FS-4 cells from the cytopathic effect of vesicular stomatitis virus; this protection was blocked by polyclonal or monoclonal antibodies that neutralize IFN-beta, suggesting that the antiviral effect was due to the secretion of IFN-beta 2 by the diC8-treated fibroblasts. 1,2-dioctanoylglycerol 0-4 interleukin 6 Homo sapiens 253-263 3108877-8 1987 The calcium ionophore A23187 (1-10 microM) also elicited an increase in the level of IFN-beta 2 mRNA in FS-4 fibroblasts; appropriate combinations of A23187 and diC8 had at least an additive effect in enhancing IFN-beta 2 mRNA levels. 1,2-dioctanoylglycerol 161-165 interleukin 6 Homo sapiens 85-95 21537388-8 2010 Of the IL6 haplotypes, GCG was associated with DD, OR 6.46 [1.61 - 26.0]. gallocatechin gallate 23-26 interleukin 6 Homo sapiens 7-10 3108877-8 1987 The calcium ionophore A23187 (1-10 microM) also elicited an increase in the level of IFN-beta 2 mRNA in FS-4 fibroblasts; appropriate combinations of A23187 and diC8 had at least an additive effect in enhancing IFN-beta 2 mRNA levels. 1,2-dioctanoylglycerol 161-165 interleukin 6 Homo sapiens 211-221 6601516-6 1983 Electrophoresis of HSF in polyacrylamide gels at pH 8.7 under nonreducing conditions revealed two regions of activity, one region migrating with albumin and the other region anodal to albumin. polyacrylamide 26-40 interleukin 6 Homo sapiens 19-22 20043958-6 2010 Investigating the effect of MG-132 on secretion of the cytokine IL-6 we show that while short-term pretreatment with MG-132 (30min) partially reduced TNFalpha-induced IL-6 via inhibition of IkappaB-alpha degradation and the NF-kappaB pathway, longer-term proteasome inhibition (up to 24h) robustly upregulated MKP-1 and was temporally correlated with repression of p38-mediated IL-6 secretion from ASM cells. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 28-34 interleukin 6 Homo sapiens 64-68 20043958-6 2010 Investigating the effect of MG-132 on secretion of the cytokine IL-6 we show that while short-term pretreatment with MG-132 (30min) partially reduced TNFalpha-induced IL-6 via inhibition of IkappaB-alpha degradation and the NF-kappaB pathway, longer-term proteasome inhibition (up to 24h) robustly upregulated MKP-1 and was temporally correlated with repression of p38-mediated IL-6 secretion from ASM cells. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 117-123 interleukin 6 Homo sapiens 64-68 20043958-6 2010 Investigating the effect of MG-132 on secretion of the cytokine IL-6 we show that while short-term pretreatment with MG-132 (30min) partially reduced TNFalpha-induced IL-6 via inhibition of IkappaB-alpha degradation and the NF-kappaB pathway, longer-term proteasome inhibition (up to 24h) robustly upregulated MKP-1 and was temporally correlated with repression of p38-mediated IL-6 secretion from ASM cells. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 117-123 interleukin 6 Homo sapiens 167-171 20043958-6 2010 Investigating the effect of MG-132 on secretion of the cytokine IL-6 we show that while short-term pretreatment with MG-132 (30min) partially reduced TNFalpha-induced IL-6 via inhibition of IkappaB-alpha degradation and the NF-kappaB pathway, longer-term proteasome inhibition (up to 24h) robustly upregulated MKP-1 and was temporally correlated with repression of p38-mediated IL-6 secretion from ASM cells. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 117-123 interleukin 6 Homo sapiens 167-171 21715345-10 2011 A significant increase in expression levels of IL-6, TNF-alpha, IL-8, MCP-1, ICAM-1, and BFGF was observed after poly (I:C) RNA stimulation (P < 0.05). Poly I-C 113-123 interleukin 6 Homo sapiens 47-51 21781004-0 2011 Interleukin-6 reduces NMDA-induced Ca2+ overload via prevention of Ca2+ release from intracellular store. N-Methylaspartate 22-26 interleukin 6 Homo sapiens 0-13 21781004-1 2011 A mechanism for neuroprotection of interleukin-6 (IL-6) via reduction of intracellular Ca2+ overload induced by N-methyl-D-aspartate (NMDA) was explored. N-Methylaspartate 112-132 interleukin 6 Homo sapiens 35-48 21781004-1 2011 A mechanism for neuroprotection of interleukin-6 (IL-6) via reduction of intracellular Ca2+ overload induced by N-methyl-D-aspartate (NMDA) was explored. N-Methylaspartate 112-132 interleukin 6 Homo sapiens 50-54 21781004-1 2011 A mechanism for neuroprotection of interleukin-6 (IL-6) via reduction of intracellular Ca2+ overload induced by N-methyl-D-aspartate (NMDA) was explored. N-Methylaspartate 134-138 interleukin 6 Homo sapiens 35-48 21781004-1 2011 A mechanism for neuroprotection of interleukin-6 (IL-6) via reduction of intracellular Ca2+ overload induced by N-methyl-D-aspartate (NMDA) was explored. N-Methylaspartate 134-138 interleukin 6 Homo sapiens 50-54 21781004-4 2011 NMDA triggered an acute and sustaining enhancement of intracellular Ca2+ fluorescence intensity in the cultured CGNs, whereas NMDA stimulation of the neurons that had been exposed to IL-6 reduced the intracellular Ca2+ fluorescence intensity relative to that of non-IL-6-pretreated neurons. N-Methylaspartate 0-4 interleukin 6 Homo sapiens 266-270 20015662-7 2010 High-glucose treated cells exhibited increased mRNA expression of TNF-alpha, IL-6, NADPH oxidase and TXNIP and gallic acid attenuated these proinflammatory and prooxidant effects. high-glucose 0-12 interleukin 6 Homo sapiens 77-81 21781004-4 2011 NMDA triggered an acute and sustaining enhancement of intracellular Ca2+ fluorescence intensity in the cultured CGNs, whereas NMDA stimulation of the neurons that had been exposed to IL-6 reduced the intracellular Ca2+ fluorescence intensity relative to that of non-IL-6-pretreated neurons. N-Methylaspartate 126-130 interleukin 6 Homo sapiens 183-187 34031685-8 2021 The results of the immune factor assays indicated that puerarin propanoate, puerarin hexanoate and puerarin myristate could significantly promote the secretion of IL-6, TNF-alpha and IL-10. puerarin propanoate 55-74 interleukin 6 Homo sapiens 163-167 21781004-4 2011 NMDA triggered an acute and sustaining enhancement of intracellular Ca2+ fluorescence intensity in the cultured CGNs, whereas NMDA stimulation of the neurons that had been exposed to IL-6 reduced the intracellular Ca2+ fluorescence intensity relative to that of non-IL-6-pretreated neurons. N-Methylaspartate 126-130 interleukin 6 Homo sapiens 266-270 21781004-9 2011 These results suggest that IL-6 has a neuroprotective effect against NMDA-induced intracellular Ca2+ overload, and that the effect is implemented primarily via a suppression of Ca2+ release from the intracellular Ca2+ store. N-Methylaspartate 69-73 interleukin 6 Homo sapiens 27-31 20026056-4 2010 PolyI:C did not expand Treg directly, but promoted the expansion of naturally occurring Treg indirectly through IL-6 produced from dendritic cells (DCs). Poly I-C 0-7 interleukin 6 Homo sapiens 112-116 20026056-5 2010 In addition, the expansion of Treg by IL-6 was inhibited by IFN-alpha from polyI:C-stimulated DCs. Poly I-C 75-82 interleukin 6 Homo sapiens 38-42 21847358-4 2011 The coculture of PDAC and CAF cell lines enhanced the levels of inflammatory factors including IL-1alpha, IL-6, CXCL8, VEGF-A, CCL20, and COX-2. pdac 17-21 interleukin 6 Homo sapiens 106-110 34031685-8 2021 The results of the immune factor assays indicated that puerarin propanoate, puerarin hexanoate and puerarin myristate could significantly promote the secretion of IL-6, TNF-alpha and IL-10. puerarin hexanoate 76-94 interleukin 6 Homo sapiens 163-167 34020271-3 2021 Our previous work has confirmed that premature senescent hepatocytes induced by Cr(VI) expressed high level of Clusterin (CLU) and secrete interleukin-6 (IL-6) and IL-8. chromium hexavalent ion 80-86 interleukin 6 Homo sapiens 139-152 20952175-6 2011 In both preadipocytes and differentiated 3T3-L1 adipocytes, lycopene preincubation for 24 h decreased the TNFalpha-mediated induction of IL-6 and MCP-1. Lycopene 60-68 interleukin 6 Homo sapiens 137-141 20538267-1 2010 This study was conducted to evaluate the efficacy of hesperetin in regulating interleukin-1beta (IL-1beta)-induced production of the matrix metalloproteinase (MMP)-3 and IL-6 in human synovial cell line, SW982. hesperetin 53-63 interleukin 6 Homo sapiens 170-174 20538267-2 2010 Treatment with hesperetin at 1 or 10 microM significantly (P<0.05) inhibited IL-1beta-induced MMP-3 and IL-6 production when measured by enzyme-linked immunosorbent assay (ELISA). hesperetin 15-25 interleukin 6 Homo sapiens 107-111 20538267-5 2010 These results suggest that hesperetin reduces the production of MMP and IL-6 in SW982 synovial cells by inhibiting JNK. hesperetin 27-37 interleukin 6 Homo sapiens 72-76 34020271-3 2021 Our previous work has confirmed that premature senescent hepatocytes induced by Cr(VI) expressed high level of Clusterin (CLU) and secrete interleukin-6 (IL-6) and IL-8. chromium hexavalent ion 80-86 interleukin 6 Homo sapiens 154-158 34020271-5 2021 In this study we demonstrated that Cr(VI) induced the secretion of tumor promoting components of SASP such as IL-6, IL-8, and granulocyte-macrophage colony stimulating factor (GM-CSF) in senescent L-02 hepatocytes, while the levels of the anti-tumor components of SASP such as chemokine (c-x-c motif) ligand-1 (CXCL-1) and monocyte chemoattractant protein-1 (MCP-1) were not altered. chromium hexavalent ion 35-41 interleukin 6 Homo sapiens 110-114 19950277-7 2009 If the importance of IL-1beta and IL-6 in the pathogenesis of MC is confirmed, these results will open the way for the evaluation of new therapies for MC. Methylcholanthrene 62-64 interleukin 6 Homo sapiens 34-38 34020271-7 2021 The NF-kappaB inhibitor PDTC significantly alleviated Cr(VI)-induced increase of IL-6, IL-8, and GM-CSF, confirming that NF-kappaB can regulate the tumor promoting components of SASP. prolinedithiocarbamate 24-28 interleukin 6 Homo sapiens 81-85 21690510-0 2011 Effect of fluticasone furoate on interleukin 6 secretion from adenoid tissues in children with obstructive sleep apnea. fluticasone furoate 10-29 interleukin 6 Homo sapiens 33-46 34020271-7 2021 The NF-kappaB inhibitor PDTC significantly alleviated Cr(VI)-induced increase of IL-6, IL-8, and GM-CSF, confirming that NF-kappaB can regulate the tumor promoting components of SASP. chromium hexavalent ion 54-60 interleukin 6 Homo sapiens 81-85 21690510-9 2011 RESULTS: Cells isolated from fluticasone furoate nasal spray-treated adenoid tissue released significantly less IL-6 spontaneously as well as upon stimulation with anti-CD3 monoclonal antibody (P = .05) compared with nontreated adenoid tissue. fluticasone furoate 29-48 interleukin 6 Homo sapiens 112-116 21690510-12 2011 CONCLUSIONS: In this study, we show reduction of IL-6, a proinflammatory cytokine, in adenoid tissue obtained from children with obstructive sleep apnea syndrome treated with fluticasone furoate nasal spray. fluticasone furoate 175-194 interleukin 6 Homo sapiens 49-53 19845437-5 2009 The serum half-life was estimated as being between 2 and 4 h. Prednisolone exhibits near complete inhibition of the cytokines TNF-alpha, IL-1beta, IL-6 and IL-8 with very similar IC50 estimates from 0.09 to 0.16 microg ml(-1) (from 0.24 to 0.44 microM). Prednisolone 62-74 interleukin 6 Homo sapiens 147-151 19783680-11 2009 Costimulation of monocytes with LPS and muramyl dipeptide induced an enhanced IL-6 response that was suppressed by siMAIL. simail 115-121 interleukin 6 Homo sapiens 78-82 33970450-7 2021 RESULTS: Based on the findings, Rifampicin and Letermovir appeared as the most promising drug showing a very good binding affinity with the main protease of SARS-CoV-2 and TNF-alpha, IL-6, and IL-1beta. Rifampin 32-42 interleukin 6 Homo sapiens 183-187 19857421-1 2009 OBJECTIVE: This study was designed to investigate whether interleukin 6 (IL-6) in cerebrospinal fluid (CSF) in the early phase of carbon monoxide (CO) poisoning can be a predictive marker of delayed encephalopathy (DE). Carbon Monoxide 130-145 interleukin 6 Homo sapiens 58-71 19857421-1 2009 OBJECTIVE: This study was designed to investigate whether interleukin 6 (IL-6) in cerebrospinal fluid (CSF) in the early phase of carbon monoxide (CO) poisoning can be a predictive marker of delayed encephalopathy (DE). Carbon Monoxide 130-145 interleukin 6 Homo sapiens 73-77 19857421-1 2009 OBJECTIVE: This study was designed to investigate whether interleukin 6 (IL-6) in cerebrospinal fluid (CSF) in the early phase of carbon monoxide (CO) poisoning can be a predictive marker of delayed encephalopathy (DE). Carbon Monoxide 147-149 interleukin 6 Homo sapiens 58-71 22384426-0 2011 Pioglitazone treatment decreases follicular fluid levels of tumor necrosis factor-alpha and interleukin-6 in patients with polycystic ovary syndrome. Pioglitazone 0-12 interleukin 6 Homo sapiens 92-105 22384426-5 2011 FF tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) concentrations at oocyte retrieval were also significantly lower in the pioglitazone group. Pioglitazone 140-152 interleukin 6 Homo sapiens 47-60 22384426-5 2011 FF tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) concentrations at oocyte retrieval were also significantly lower in the pioglitazone group. Pioglitazone 140-152 interleukin 6 Homo sapiens 62-66 22384426-7 2011 CONCLUSION: Pioglitazone reduces FF TNF-alpha and IL-6 levels, and may improve ovarian response to COS in patients with PCOS. Pioglitazone 12-24 interleukin 6 Homo sapiens 50-54 19857421-1 2009 OBJECTIVE: This study was designed to investigate whether interleukin 6 (IL-6) in cerebrospinal fluid (CSF) in the early phase of carbon monoxide (CO) poisoning can be a predictive marker of delayed encephalopathy (DE). Carbon Monoxide 147-149 interleukin 6 Homo sapiens 73-77 33970450-7 2021 RESULTS: Based on the findings, Rifampicin and Letermovir appeared as the most promising drug showing a very good binding affinity with the main protease of SARS-CoV-2 and TNF-alpha, IL-6, and IL-1beta. letermovir 47-57 interleukin 6 Homo sapiens 183-187 33965881-2 2021 This study was aimed to assess the effect of in vitro calcitriol immunomodulatory effect on IL-6, IL-10 and IFN-gamma in elderly patients who were fit, pre-frail and frail to see which group of patients might get the most benefit of calcitriol. Calcitriol 54-64 interleukin 6 Homo sapiens 92-96 19362013-13 2009 The PV/PA ratio of IL-6 was higher in the sufentanil group. pv 4-6 interleukin 6 Homo sapiens 19-23 21310803-5 2011 RESULTS: Imatinib mesylate significantly (p=0.005) reduced IL-6 and hyaluronan production. Imatinib Mesylate 9-17 interleukin 6 Homo sapiens 59-63 33958640-5 2021 Among 19 carriers, 7 with both heterozygous IL6 rs13306435 and CRIM1 rs3821169 showed significantly decreased DIP (24.7 +- 8.9%) than those with IL6 (N = 12, 61.6 +- 25.1%) or CRIM1 (N = 94, 68.1 +- 28.4%) variants. dip 110-113 interleukin 6 Homo sapiens 44-47 33878273-7 2021 We also show that soft AIE dots loaded with cytosine-phosphate-guanine (CpG) oligodeoxynucleotides can induce strong immunostimulatory effects, producing a high level of various proinflammatory cytokines including tumor necrosis factor (TNF)-R, interleukin (IL)-6, and IL-12. cytosine-phosphate-guanine 44-70 interleukin 6 Homo sapiens 245-263 21484151-0 2011 Lycopene inhibits IL-6 expression in cerulein-stimulated pancreatic acinar cells. Lycopene 0-8 interleukin 6 Homo sapiens 18-22 21484151-10 2011 Lycopene inhibited the cerulein-induced increase in intracellular ROS, NF-kappaB activation, and IL-6 expression in pancreatic acinar cells in a dose-dependent manner. Lycopene 0-8 interleukin 6 Homo sapiens 97-101 19635904-8 2009 Moreover CD8alpha(+) conventional dendritic cells (cDCs), but not CD8alpha(-) cDCs, expressed genes for type I IFNs, IL-6, and IL-12p40 in response to poly I:C stimulation, and were also responsible for inducing IFN-gamma production in NK cells. Poly I-C 151-159 interleukin 6 Homo sapiens 117-121 34017261-7 2021 In this article, we found that XH significantly inhibited inflammatory responses, attenuated catabolic enzymes expression, and ameliorated ECM degradation, as showed by decreased production of NO, PGE2, TNFalpha, and IL-6, decreased expression of MMP-3/-13 and ADAMTS-4/-5, and increased expression of collagen-II and aggrecan. xanthohumol 31-33 interleukin 6 Homo sapiens 217-221 19242516-6 2009 Furthermore, poly(I:C) significantly enhanced LC survival and induced them to produce CXCL10, IL-6, and IL-12 p40. Poly I-C 13-21 interleukin 6 Homo sapiens 94-98 18824341-8 2009 Preincubation of airway epithelial cells with lycopene (dissolved in tetrahydrofuran) delivered lycopene into the cells and resulted in a 24% reduction in interleukin-6 after rhinovirus-1B infection, 31% reduction in IP-10 after rhinovirus-43 infection and 85% reduction in rhinovirus-1B replication. Lycopene 46-54 interleukin 6 Homo sapiens 155-168 21288261-5 2011 Using two potent and selective inhibitors of MEK activation by Raf-1 (PD-098059) and p38 (SB-203580), it was also demonstrated that both ERK1/2 and p38 pathways play key roles in the production of IL-6 as well as in ICAM-1, VCAM-1 and E-selectin expression by Hib porin. SB 203580 90-99 interleukin 6 Homo sapiens 197-201 21481788-4 2011 Using genetic tools, we show that inactivation of IL-6 transsignaling or Stat3 inhibits PanIN progression and reduces the development of PDAC. pdac 137-141 interleukin 6 Homo sapiens 50-54 33592131-5 2021 RESULTS: In the lipo-PGE1 group, the peritoneal clearance rates of beta2-MG, cystatin C, and albumin were significantly increased comparing with pre-treatment values, and the IL-6 appearance rate (AR) in the peritoneal dialysate and the serum levels of IL-6 and hs-CRP were markedly decreased (p < 0.05). Alprostadil 21-25 interleukin 6 Homo sapiens 175-179 20717763-0 2011 Neuroprotection of interleukin-6 against NMDA-induced apoptosis and its signal-transduction mechanisms. N-Methylaspartate 41-45 interleukin 6 Homo sapiens 19-32 19575800-1 2009 BACKGROUND: Previously we showed that reduced availability of the essential amino acid tryptophan per se attenuates post-transcriptional control of interleukin (IL)-6 and IL-8 leading to hyperresponsive production of these inflammatory mediators by airway epithelial cells. essential amino acid tryptophan 66-97 interleukin 6 Homo sapiens 148-166 19172342-7 2009 Strong positive associations were found between BMI and levels of IL-6 (r=0.52) and epinephrine (r=0.54), and somewhat weaker associations with cortisol (r=0.32) and CRP (r=0.37). Epinephrine 84-95 interleukin 6 Homo sapiens 66-70 21161336-3 2011 The current study examines whether difluorinated-curcumin (CDF), a novel analog of the dietary ingredient of curcumin, in combination with 5-fluorouracil and oxaliplatin (5-FU + Ox), the mainstay of colon cancer chemotherapeutic, would be effective in eliminating colon CSCs. difluorinated-curcumin 35-57 interleukin 6 Homo sapiens 59-62 33592131-5 2021 RESULTS: In the lipo-PGE1 group, the peritoneal clearance rates of beta2-MG, cystatin C, and albumin were significantly increased comparing with pre-treatment values, and the IL-6 appearance rate (AR) in the peritoneal dialysate and the serum levels of IL-6 and hs-CRP were markedly decreased (p < 0.05). Alprostadil 21-25 interleukin 6 Homo sapiens 253-257 21073547-5 2011 In vitro studies in human lung epithelial cell lines showed that levofloxacin led to a dose-related reduction in IL-6 and IL-8 concentrations, with 300 mug mL(-1) resulting in the reduction of levels of IL-6 by fourfold and IL-8 by twofold (P<0.05); in contrast, tobramycin increased IL-6 levels by 50%, but had no effect on IL-8. Tobramycin 266-276 interleukin 6 Homo sapiens 203-207 19259613-5 2009 Cucurbitacin I (STAT3 inhibitor), but not U0126 (MAPK inhibitor), could abolish the effect of IL-6. cucurbitacin I 0-14 interleukin 6 Homo sapiens 94-98 33526759-6 2021 Moreover, the application of GL can effectively relieve UV radiation induced erythema and leathery skin, associated with the down-regulated expression of inflammatory cytokines (TNF-alpha, IL-6 and IL-10). gl 29-31 interleukin 6 Homo sapiens 189-193 19249598-5 2009 A p38 mitogen-activated protein kinase inhibitor, SB203580, also inhibited the increase in IL-6 messenger RNA levels. SB 203580 50-58 interleukin 6 Homo sapiens 91-95 21073547-5 2011 In vitro studies in human lung epithelial cell lines showed that levofloxacin led to a dose-related reduction in IL-6 and IL-8 concentrations, with 300 mug mL(-1) resulting in the reduction of levels of IL-6 by fourfold and IL-8 by twofold (P<0.05); in contrast, tobramycin increased IL-6 levels by 50%, but had no effect on IL-8. Tobramycin 266-276 interleukin 6 Homo sapiens 203-207 21196090-11 2011 The mRNA expression of IL-6 in the BTS inseminated group was higher compared to the control group. Pyruvic Acid 35-38 interleukin 6 Homo sapiens 23-27 33894712-10 2021 A negative correlation was observed between AZM concentration in lung tissue and interleukin-6 (IL-6) expression. Azithromycin 44-47 interleukin 6 Homo sapiens 81-94 21165548-3 2011 In the present study, we demonstrate that artemisinin inhibits the secretion and the mRNA levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1ss, and IL-6 in a dose-dependent manner in phorbol 12-myristate 13-acetate (PMA)-induced THP-1 human monocytes. artemisinin 42-53 interleukin 6 Homo sapiens 161-165 19146941-5 2009 RESULTS: HaCaT cells induced the pro-inflammatory cytokines, interleukin-8 (IL-8) and/or interleukin-6 (IL-6) expressions after treatment with polyI:C or PGN. Poly I-C 143-150 interleukin 6 Homo sapiens 89-102 19146941-5 2009 RESULTS: HaCaT cells induced the pro-inflammatory cytokines, interleukin-8 (IL-8) and/or interleukin-6 (IL-6) expressions after treatment with polyI:C or PGN. Poly I-C 143-150 interleukin 6 Homo sapiens 104-108 33894712-10 2021 A negative correlation was observed between AZM concentration in lung tissue and interleukin-6 (IL-6) expression. Azithromycin 44-47 interleukin 6 Homo sapiens 96-100 19494504-11 2009 Eotaxin-induced production of IL-1beta, IL-6, and MIP-1beta was significantly reduced by the MEK inhibitor PD98059, p38 MAPK inhibitor SB203580, or PI3K inhibitor LY294002. SB 203580 135-143 interleukin 6 Homo sapiens 40-44 33724512-4 2021 Administration of TTP448 in an AD cell model reduced the expression of pro-inflammatory cytokines [interleukin (IL)-1beta, IL-6, and TNF-alpha], reversed the inhibitory role of Abeta on cell proliferation and viability, and decreased Abeta-triggered cell apoptosis and reactive oxygen species (ROS) production. Azeliragon 18-24 interleukin 6 Homo sapiens 123-127 18515973-0 2009 7-Ketocholesterol upregulates interleukin-6 via mechanisms that are distinct from those of tumor necrosis factor-alpha, in vascular smooth muscle cells. 7-ketocholesterol 0-17 interleukin 6 Homo sapiens 30-43 18515973-1 2009 This study investigated the effects of 7-ketocholesterol on interleukin (IL)-6 expression in vascular smooth muscle cells (VSMC). 7-ketocholesterol 39-56 interleukin 6 Homo sapiens 60-78 18515973-2 2009 Among the 7 IL examined, only IL-6 transcript was increased by 7-ketocholesterol treatment in human aorta smooth muscle cells. 7-ketocholesterol 63-80 interleukin 6 Homo sapiens 30-34 18515973-3 2009 IL-6 transcripts increased up to 24 h after treatment with 7-ketocholesterol, and this effect was profoundly repressed by treatment with p38 MAPK inhibitors and to a lesser extent JNK inhibitors. 7-ketocholesterol 59-76 interleukin 6 Homo sapiens 0-4 18515973-5 2009 Mechanisms of IL-6 induction by 7-ketocholesterol were investigated in comparison with tumor necrosis factor (TNF)-alpha. 7-ketocholesterol 32-49 interleukin 6 Homo sapiens 14-18 18515973-8 2009 7-ketocholesterol significantly increased the amount of intracellular IL-6 protein in the presence of brefeldin A. 7-ketocholesterol 0-17 interleukin 6 Homo sapiens 70-74 22471481-1 2011 BACKGROUND AND AIMS: IL-6 has been implicated in both virus-associated and diethylnitrosamine-induced hepatocellular carcinomas (HCCs). Diethylnitrosamine 75-93 interleukin 6 Homo sapiens 21-25 21176394-7 2011 The IL-6 secretory pathway of MSCs was inhibited by SB203580, an inhibitor of p38 MAPK or siRNA against p38 MAPK, suggesting IL-6 secretion by MSCs is mediated through the activation of p38 MAPK. SB 203580 52-60 interleukin 6 Homo sapiens 4-8 22152139-10 2011 NF-kappaB activity and levels of TNF-alpha,IL-1 and IL-6 were lower in ulinastain group than control one, without any significant difference between the two groups. ulinastain 72-82 interleukin 6 Homo sapiens 53-57 18515973-9 2009 7-Ketocholesterol also enhanced IL-6 release from VSMC. 7-ketocholesterol 0-17 interleukin 6 Homo sapiens 32-36 33545548-10 2021 Treatment with KAM-BYF markedly decreased the levels of interleukin 6 (IL6), tumor necrosis factor-alpha (TNF-alpha), matrix metalloproteinase 9 (MMP9), and MMP12 in serum and bronchial alveolar lavage fluid. kam-byf 15-22 interleukin 6 Homo sapiens 56-69 18515973-10 2009 IL-6 release by 7-ketocholesterol, although significant, was not as remarkable as that induced by TNF-alpha. 7-ketocholesterol 16-33 interleukin 6 Homo sapiens 0-4 18515973-11 2009 These data suggest that 7-ketocholesterol upregulates IL-6 via mechanisms distinct from TNF-alpha and contributes to the intra- and extracellular IL-6 deposits within the vasculature. 7-ketocholesterol 24-41 interleukin 6 Homo sapiens 54-58 18515973-11 2009 These data suggest that 7-ketocholesterol upregulates IL-6 via mechanisms distinct from TNF-alpha and contributes to the intra- and extracellular IL-6 deposits within the vasculature. 7-ketocholesterol 24-41 interleukin 6 Homo sapiens 146-150 19164258-7 2009 beta-Cryptoxanthin, lycopene, and lutein/zeaxanthin concentrations were inversely related to interleukin-6 concentrations. Beta-Cryptoxanthin 0-18 interleukin 6 Homo sapiens 93-106 21084452-6 2011 Similar to dexamethasone (DEX), CpdA profoundly suppressed lipopolysaccharide-induced TNF-alpha (-63%), IL-1beta (-38%), and IL-6 (-36%) (P < 0.05) mRNA levels. CPDA 32-36 interleukin 6 Homo sapiens 125-129 19164258-7 2009 beta-Cryptoxanthin, lycopene, and lutein/zeaxanthin concentrations were inversely related to interleukin-6 concentrations. Lycopene 20-28 interleukin 6 Homo sapiens 93-106 33545548-10 2021 Treatment with KAM-BYF markedly decreased the levels of interleukin 6 (IL6), tumor necrosis factor-alpha (TNF-alpha), matrix metalloproteinase 9 (MMP9), and MMP12 in serum and bronchial alveolar lavage fluid. kam-byf 15-22 interleukin 6 Homo sapiens 71-74 20920950-6 2011 RESULTS: Compared with controls, NLF interleukin-6 (IL-6) responses to LAIV (peak and total) were suppressed in smokers. laiv 71-75 interleukin 6 Homo sapiens 37-50 20920950-6 2011 RESULTS: Compared with controls, NLF interleukin-6 (IL-6) responses to LAIV (peak and total) were suppressed in smokers. laiv 71-75 interleukin 6 Homo sapiens 52-56 20920950-9 2011 We observed significant associations between urine cotinine and NLF IL-6 responses (negative correlation) or virus RNA in NLF cells (positive correlation) for all subjects combined. Cotinine 51-59 interleukin 6 Homo sapiens 68-72 25414542-10 2009 IL-6 increased significantly in the CSRA group (pre = 0.7, post = 0.8 pg/mL), but not in the comparison group. csra 36-40 interleukin 6 Homo sapiens 0-4 33602262-7 2021 RESULTS: All the SSRIs, including paroxetine, fluoxetine, sertraline, citalopram, and fluvoxamine, show a visible cytotoxicity within the range of applied doses, and a paradoxical effect on astrocytic inflammatory responses as manifested by the promotion of inducible nitric oxide synthase (iNOS) and/or nitric oxide (NO) and the inhibition of interleukin 6 (IL-6) and/or interleukin 1beta (IL-1beta). Fluvoxamine 86-97 interleukin 6 Homo sapiens 344-357 33602262-7 2021 RESULTS: All the SSRIs, including paroxetine, fluoxetine, sertraline, citalopram, and fluvoxamine, show a visible cytotoxicity within the range of applied doses, and a paradoxical effect on astrocytic inflammatory responses as manifested by the promotion of inducible nitric oxide synthase (iNOS) and/or nitric oxide (NO) and the inhibition of interleukin 6 (IL-6) and/or interleukin 1beta (IL-1beta). Fluvoxamine 86-97 interleukin 6 Homo sapiens 359-363 20859299-8 2011 Volunteers from the TRF group produced significantly (P < 0.05) lower amounts of IL-6 compared with the placebo group. Thyrotropin-Releasing Hormone 20-23 interleukin 6 Homo sapiens 84-88 33602262-8 2021 The SNRI venlafaxine was the least toxic to astrocytes and inhibited the production of IL-6 and IL-1beta but with no impact on iNOS and NO. Venlafaxine Hydrochloride 9-20 interleukin 6 Homo sapiens 87-91 18557924-6 2008 Taurine inhibited UVA-induced interleukin-6 (Il-6) mRNA expression by 40%. Taurine 0-7 interleukin 6 Homo sapiens 30-43 33568652-6 2021 These epoxides reduce the pro-inflammatory biomarkers IL-6, IL-1beta, TNF-alpha and nitrous oxide and raise anti-inflammatory IL-10 cytokine in activated microglial cells. Epoxy Compounds 6-14 interleukin 6 Homo sapiens 54-58 18557924-6 2008 Taurine inhibited UVA-induced interleukin-6 (Il-6) mRNA expression by 40%. Taurine 0-7 interleukin 6 Homo sapiens 45-49 18557924-7 2008 Furthermore, Il-6 accumulation in the supernatants of UVA-irradiated dermal fibroblasts was much slower when cells were preincubated with taurine. Taurine 138-145 interleukin 6 Homo sapiens 13-17 18557924-8 2008 These data indicate that taurine accumulation seems to be part of the fibroblast response to UVA radiation and may protect against UVA-induced Il-6 overexpression. Taurine 25-32 interleukin 6 Homo sapiens 143-147 24900298-3 2011 LAS101057 inhibits agonist-induced IL-6 production in human fibroblasts and is active in an ovalbumin (OVA)-sensitized mouse model after oral administration, reducing airway hyperresponsiveness to methacholine, Th2 cytokine production, and OVA-specific IgE levels. LAS101057 0-9 interleukin 6 Homo sapiens 35-39 20337818-5 2010 CRP and IL-6 correlated with PASI. pasi 29-33 interleukin 6 Homo sapiens 8-12 33628506-14 2021 The administration of azithromycin to the Control group increased CRP and IL-6 levels, while reduced IL-10 and TNF-alpha on day 7 (p < 0.0001) compared with day 1. Azithromycin 22-34 interleukin 6 Homo sapiens 74-78 21267384-9 2010 Homeostatic model assessment-index, interleukin-6, and tumor necrosis factor-alpha levels were significantly lower in the pioglitazone group at 8 months. Pioglitazone 122-134 interleukin 6 Homo sapiens 36-82 19017992-4 2008 We discovered mianserin was able to inhibit the endosomal TLRs 3, 7, 8, and 9 in primary human cells and inhibited the spontaneous release of TNF and IL-6 from RA synovial membrane cultures. Mianserin 14-23 interleukin 6 Homo sapiens 150-154 18631340-7 2008 There was positive correlation between level of isoprostane-8 and IL-6 and value of clinical score {p < 0.0001*} and also with the degree of the cardiac dysfunction in those children. Isoprostanes 48-59 interleukin 6 Homo sapiens 66-70 33559851-0 2021 Citrate high volume on-line hemodiafiltration modulates serum Interleukin-6 and Klotho levels: the multicenter randomized controlled study "Hephaestus". Citric Acid 0-7 interleukin 6 Homo sapiens 62-75 18787413-6 2008 c-kit inhibition by imatinib mesylate (Gleevec) in DCs was previously shown to promote natural killer cell activation which may be due to dampening of IL-6 production by the DCs. Imatinib Mesylate 20-37 interleukin 6 Homo sapiens 151-155 20709105-5 2010 Intranasally administered DBF and the mixture of virus+DBF induced an elevated expression of IFN-gamma, IL-6 and IL-10 cytokines, type I interferons, iNOS, and pDC markers in NALT. Dibenzofurans 26-29 interleukin 6 Homo sapiens 104-108 33559851-14 2021 CONCLUSIONS: Citrate buffer modulated IL-6, hsCRP and Klotho levels during high volume OL-HDF. Citric Acid 13-20 interleukin 6 Homo sapiens 38-42 18689371-4 2008 RESULTS: Cross-sectionally, plasma phylloquinone was inversely associated with IL-6 and CRP, whereas serum %ucOC was inversely associated with IL-6. Vitamin K 1 35-48 interleukin 6 Homo sapiens 79-91 33533162-6 2021 Among these, (+)-terrein (3) exhibited IL-6 and TNF-alpha inhibition activity with IC50 of 8.5+-0.68 muM and 15.76+-0.18 muM, respectively, while butyrolactone I (4) exhibited IC50 of 12.03+-0.85 muM (IL-6) and 43.29+-0.76 muM (TNF-alpha) inhibition activity with low toxicity to host cells in LPS stimulated THP-1 cells. terrein 17-24 interleukin 6 Homo sapiens 39-43 18689371-4 2008 RESULTS: Cross-sectionally, plasma phylloquinone was inversely associated with IL-6 and CRP, whereas serum %ucOC was inversely associated with IL-6. Vitamin K 1 35-48 interleukin 6 Homo sapiens 79-83 18660424-9 2008 Poly(I:C)-induced expression of IL-6, IL-8, G-CSF, MIP-1beta, exotaxin, RANTES, and ICAM-1 was inhibited differentially by the MAPK inhibitors PD98059 and SB203580 and by JNK inhibitor II. Poly I-C 0-8 interleukin 6 Homo sapiens 32-36 20815816-6 2010 Inhibition of hemichannel activity with carbenoxolone or apyrase prevented induction of IL-6 and TLR2 mRNA expression by PGN, but had no effect on Cx43 mRNA expression levels. Carbenoxolone 40-53 interleukin 6 Homo sapiens 88-92 33533162-6 2021 Among these, (+)-terrein (3) exhibited IL-6 and TNF-alpha inhibition activity with IC50 of 8.5+-0.68 muM and 15.76+-0.18 muM, respectively, while butyrolactone I (4) exhibited IC50 of 12.03+-0.85 muM (IL-6) and 43.29+-0.76 muM (TNF-alpha) inhibition activity with low toxicity to host cells in LPS stimulated THP-1 cells. terrein 17-24 interleukin 6 Homo sapiens 201-205 20456615-9 2010 IL-6 and IL-8 production was increased by Pam(3) CSK(4) , flagellin, Poly I:C, and imiquimod, but not lipopolysaccharide (LPS). Poly I-C 69-77 interleukin 6 Homo sapiens 0-4 32881084-8 2021 The binary complex is primarily stabilized by two pairs of salt bridges, Arg181 (hIL-6)- Glu182 (IL-6Ralpha) and Arg184 (hIL-6)- Glu183 (IL-6Ralpha) as well as hydrophobic and aromatic stacking interactions mediated essentially by Phe residues in both proteins. Phenylalanine 231-234 interleukin 6 Homo sapiens 121-126 20734355-6 2010 Mechanistically, GMSC treatment mitigated local inflammation mediated by a suppressed infiltration of inflammatory cells and production of IL-6 and TNF-alpha, and an increased expression of IL-10. gmsc 17-21 interleukin 6 Homo sapiens 139-143 22870451-4 2010 IL-6 may also be mediating many of the systematic manifestations of RA including inducing the acute-phase reaction [including C-reactive protein (CRP)], anaemia through hecipidin production, fatigue via the hypothalamic-pituitary-adrenal (HPA) axis) and osteoporosis from its effect on osteoclasts. hecipidin 169-178 interleukin 6 Homo sapiens 0-4 20347984-4 2010 Manidipine 1-5 microM was able to completely inhibit IL-6 production induced by either of these factors. manidipine 0-10 interleukin 6 Homo sapiens 53-57 20347984-6 2010 In human macrophages THP-1, treatment with different cytokines was able to stimulate by about 3-folds the release of IL-6 and Manidipine 1 microM showed a 25% inhibition on TNF-alpha-induced IL-6 secretion. manidipine 126-136 interleukin 6 Homo sapiens 191-195 18686625-0 2008 Mek and p38 MAPK-dependant pathways are involoved in the positive effect of interleukin-6 on human growth hormone gene expression in rat MtT/S somatotroph cells. monooxyethylene trimethylolpropane tristearate 137-140 interleukin 6 Homo sapiens 76-89 18430611-3 2008 The growth-inhibitory activity of gemcitabine-loaded liposomes compared to the free drug was assayed in vitro on U266 (autocrine, interleukin-6-independent) and INA-6 (IL-6-dependent) multiple myeloma cell lines. gemcitabine 34-45 interleukin 6 Homo sapiens 130-143 18430611-3 2008 The growth-inhibitory activity of gemcitabine-loaded liposomes compared to the free drug was assayed in vitro on U266 (autocrine, interleukin-6-independent) and INA-6 (IL-6-dependent) multiple myeloma cell lines. gemcitabine 34-45 interleukin 6 Homo sapiens 168-172 33058999-7 2021 PCN-224 might trigger inflammation by promoting the secretion of inflammatory factors such as Tumor necrosis factors (TNF-alpha) and Interleukin (IL-6). pcn-224 0-7 interleukin 6 Homo sapiens 146-150 17724435-10 2008 SB203580 also prevented the CytoMix-induced permeability increase and reduced NO, IL-6, and IL-8 levels. SB 203580 0-8 interleukin 6 Homo sapiens 82-86 20546727-7 2010 The decorin gene cloned into mammalian expression vector was introduced into HSF with lipofectamine transfection kit. Lipofectamine 86-99 interleukin 6 Homo sapiens 77-80 33479266-8 2021 Finally, the multi-omic integrative analysis suggested a relationship between cytokines CCL20, CX3CL1, CXCL13, IL-15, IL-22 and IL-6 with alteration in chemotaxis, as well as a link between long-chain unsaturated phospholipids and the increased fatty acid transport and prostaglandin production. long-chain unsaturated phospholipids 190-226 interleukin 6 Homo sapiens 128-132 19844976-6 2010 Furthermore, cobalt, molybdenum ions, and Co-Cr-Mo alloy particles similarly induce elevated secretion of IL-1beta, TNFalpha, and IL-6. co-cr-mo 42-50 interleukin 6 Homo sapiens 130-134 20368333-9 2010 The donating agents and the L-DOPA hybrids reduced the release of tumor necrosis factor-alpha, interleukin-6, and nitric oxide from stimulated microglia, astrocytes as well as the THP-1 and U373 cell lines. Levodopa 28-34 interleukin 6 Homo sapiens 95-108 18843975-6 2008 Imatinib inhibited expression of c-kit and provoked a decrease of IL-6 induced c-kit phosphorylation in vitro. Imatinib Mesylate 0-8 interleukin 6 Homo sapiens 66-70 17881186-2 2008 We investigated the effect of aspirin and propranolol on the responsiveness of plasma IL-6 levels to acute psychosocial stress. Propranolol 42-53 interleukin 6 Homo sapiens 86-90 33461822-9 2021 In addition, the protein expression of IL-6/8/10 and TNF-alpha was reduced by the perfusion of papaverine. Papaverine 95-105 interleukin 6 Homo sapiens 39-48 18166485-5 2008 RESULTS: Both groups exhibited a significant positive correlation between IL-6 and levothyroxine replacement dosage (group A: r=0.708, p<0.001; group B: r=0.345, p=0.012) and a negative correlation between IL-6 and T3 (group A: r=-0.342, p=0.023, group B: r=-0.294, p=0.035). Thyroxine 83-96 interleukin 6 Homo sapiens 74-78 18166485-6 2008 Significant independent predictors of levothyroxine replacement dosage were IL-6 (p<0.001) and TNF-alpha (p=0.007) in group A (58.3% of dosage variation) and only IL-6 (p=0.012) in group B (10.1% of dosage variation). Thyroxine 38-51 interleukin 6 Homo sapiens 76-80 20231081-5 2010 GR function was measured by glucocorticoid inhibition of lypopolysaccharide (LPS)-stimulated interleukin-6 (IL-6) levels. lps 77-80 interleukin 6 Homo sapiens 93-106 20231081-5 2010 GR function was measured by glucocorticoid inhibition of lypopolysaccharide (LPS)-stimulated interleukin-6 (IL-6) levels. lps 77-80 interleukin 6 Homo sapiens 108-112 20231081-6 2010 Compared to vehicle-treated cells, all antidepressants inhibited dexamethasone (DEX, 10-100nM) inhibition of LPS-stimulated IL-6 levels (p values ranging from 0.007 to 0.1). lps 109-112 interleukin 6 Homo sapiens 124-128 18166485-7 2008 CONCLUSIONS: In both groups, a significant positive correlation was observed between IL-6 and levothyroxine replacement dosage, but this correlation was stronger in group A. Thyroxine 94-107 interleukin 6 Homo sapiens 85-89 33414242-2 2021 In a predefined substudy of the original AMAZES protocol (500 mg, three times a week for 48 weeks), we report that AZM treatment reduces key sputum inflammatory proteins (interleukin (IL)-6, IL-1beta and extracellular DNA), which is more evident in non-eosinophilic asthma (NEA). Azithromycin 115-118 interleukin 6 Homo sapiens 171-189 18211669-1 2008 BACKGROUND: Because of the possible role of cytokines including interleukins (IL) in systemic non-thyroidal illnesses" (NTI) pathogenesis and consequently the frequently associated alterations in thyroid hormone (TH) concentrations constituting the euthyroid sick syndrome (ESS), we aimed in this research to elucidate the possible relation between IL-6 & IL-10 and any documented ESS in a cohort of patients with NTI. naltrindole 120-123 interleukin 6 Homo sapiens 349-353 20200221-8 2010 Exposure to 4-OPA significantly elevated IL-8, IL-6, GM-CSF, and TNF-alpha while glutaraldehyde caused significant elevations in IL-6, IL-8, and TNF-alpha. 4-oxopentanal 12-17 interleukin 6 Homo sapiens 47-51 20520770-5 2010 PGN-SA induced phosphorylation of TAK1 and IkappaB in the TLR2-NF-kappaB pathway of the cancer cells and stimulated IL-6 and TGF-beta secretion in MDA-MB-231 cells. pgn-sa 0-6 interleukin 6 Homo sapiens 116-120 33132153-4 2021 The intracellular accumulation of endogenous kynurenic acid due to overexpression of the indoleamine 2,3-dioxygenase (IDO) by AhR activation induces AhR-interleukin-6 (IL-6)-signal transducers and activators of the transcription 3 (STAT3) signaling pathway. Kynurenic Acid 45-59 interleukin 6 Homo sapiens 168-172 20360315-7 2010 A set of 72 a priori-selected candidate genes did not show pharmacogenetic associations above a chance level, but an association with response to escitalopram was detected in the interleukin-6 gene, which is a close homologue of IL11. Citalopram 146-158 interleukin 6 Homo sapiens 179-192 17981627-4 2008 Inflammatory response after stroke suggests that cytokines (TNF-alpha, IL-1alpha/beta, IL-6), affect the phospholipid metabolism and subsequent production of eicosanoids, ceramide, and ROS that may potentiate brain injury. Ceramides 171-179 interleukin 6 Homo sapiens 87-91 18696354-11 2008 In the group of patients treated with prednisolone, significantly lower IL-6 levels were observed during a HELLP exacerbation, compared with patients who did not receive prednisolone (p < 0.01). Prednisolone 38-50 interleukin 6 Homo sapiens 72-76 18696354-13 2008 Circulating IL-6 levels in HELLP syndrome are reduced during prednisolone administration, suggesting a stabilizing effect on the inflammatory endothelial process. Prednisolone 61-73 interleukin 6 Homo sapiens 12-16 33218942-8 2021 The expressions of TLR4/NF-kappaBp65, IL-1beta, IL-6, IL-8, and TNF-alpha significantly increased in the model group while they were down-regulated in the rebamipide pretreatment group (p < 0.05). rebamipide 155-165 interleukin 6 Homo sapiens 48-52 19367004-12 2008 CONCLUSIONS: The high frequency of ESS in patients with NTI may be linked to IL-6 and IL-10 alterations. naltrindole 56-59 interleukin 6 Homo sapiens 77-81 20110528-5 2010 Treatment with CS at 200 and 1000 microg/ml was performed on human OA cartilage explants in the presence/absence of interleukin 1ss (IL-1ss), and the protein modulations of factors including prostaglandin E(2) (PGE(2)), IL-6, and MMP-1 measured by ELISA. Chondroitin Sulfates 15-17 interleukin 6 Homo sapiens 220-224 21348395-6 2010 Positive BHT was present in 10 patients, showing a high prevalence of GI macronutrient malabsorption and maldigestion, and compared with the other patients, the highest plasma levels of tumor necrosis factor alpha and interleukin 6 and lower levels of albumin and prealbumin. Butylated Hydroxytoluene 9-12 interleukin 6 Homo sapiens 218-274 18184212-0 2008 Early amelioration of insulin resistance and reduction of interleukin-6 in Werner syndrome using pioglitazone. Pioglitazone 97-109 interleukin 6 Homo sapiens 58-71 33832346-1 2021 This study monitored the changes in the expression of inflammatory IL-6 and IL-1beta during the treatment period of Fluoropyrimidine (FP) based therapy. fp 134-136 interleukin 6 Homo sapiens 67-71 18332643-3 2008 OBJECTIVES: We hypothesize that end-tidal carbon monoxide corrected for inhaled CO (ETCOc), malondialdehyde (MDA) (markers of oxidative stress) and proinflammatory cytokine (IL-6, IL-8) production are higher in infants of preeclamptic mothers with HELLP syndrome than in those of preeclamptic mothers without HELLP syndrome. Carbon Monoxide 42-57 interleukin 6 Homo sapiens 174-178 17867636-3 2007 Exposure to whole orange juice resulted in an increase in IL-6 formation of 23% compared to nontreated control cells, whereas treatment of the cells with either DM or AD resulted in a 22 or 1% increase, respectively. whole 12-17 interleukin 6 Homo sapiens 58-62 20430256-5 2010 Taurine, a semi-essential amino acid, is an antioxidant, inhibits the production of proinflammatory cytokines such as IL-1 and IL-6 and also inhibits production of TGF-beta, a major fibrogenic cytokine. Taurine 0-7 interleukin 6 Homo sapiens 127-131 19711464-0 2009 Vorinostat in advanced prostate cancer patients progressing on prior chemotherapy (National Cancer Institute Trial 6862): trial results and interleukin-6 analysis: a study by the Department of Defense Prostate Cancer Clinical Trial Consortium and University of Chicago Phase 2 Consortium. Vorinostat 0-10 interleukin 6 Homo sapiens 140-153 19711464-4 2009 Secondary endpoints included safety, rate of PSA decline, objective response, overall survival, and effects of vorinostat on serum interleukin-6 (IL-6) levels. Vorinostat 111-121 interleukin 6 Homo sapiens 131-144 33832346-6 2021 FP therapy significantly induced IL-6 and IL-1beta expression. fp 0-2 interleukin 6 Homo sapiens 33-37 19711464-4 2009 Secondary endpoints included safety, rate of PSA decline, objective response, overall survival, and effects of vorinostat on serum interleukin-6 (IL-6) levels. Vorinostat 111-121 interleukin 6 Homo sapiens 146-150 33832346-7 2021 Subgroup analysis showed that patients with right colon tumors had significant elevation in both IL-6 and IL-1beta with FP therapy. fp 120-122 interleukin 6 Homo sapiens 97-101 19669729-0 2009 Link between plasma ceramides, inflammation and insulin resistance: association with serum IL-6 concentration in patients with coronary heart disease. Ceramides 20-29 interleukin 6 Homo sapiens 91-95 33211383-11 2021 Besides, maltol not only suppressed the production of COX-2, iNOs, TNF-alpha, IL-6, ADAMTS-5, MMP-13, but also attenuated the degradation of collagen II and aggrecan. maltol 9-15 interleukin 6 Homo sapiens 78-82 19669729-2 2009 We sought to assess the associations of circulating levels of IL-6, TNF-alpha and high-sensitivity C reactive protein (hsCRP), which are inflammatory markers related to insulin resistance (IR), with the plasma lipid metabolites ceramides and diacylglycerols (DAG) in patients with CHD. Ceramides 228-237 interleukin 6 Homo sapiens 62-66 19669729-5 2009 RESULTS: Serum circulating levels of IL-6 were strongly correlated with plasma ceramide concentrations (r = 0.59, p < 0.001). Ceramides 79-87 interleukin 6 Homo sapiens 37-41 19669729-8 2009 In a linear regression model, circulating levels of both ceramides and TNF-alpha had a significant independent influence on circulating levels of IL-6, altogether accounting for 41% of its variation (p < 0.001). Ceramides 57-66 interleukin 6 Homo sapiens 146-150 19669729-9 2009 CONCLUSIONS/INTERPRETATION: Our results strongly suggest that the link between ceramides, IR and inflammation is related to the inflammatory marker IL-6. Ceramides 79-88 interleukin 6 Homo sapiens 148-152 17705048-5 2007 Treatment of MG-63 cells with adenosine and pharmacological ADORA agonist 5"-N-ethylcarboxamidoadenosine or 2-[4-(2-p-carboxyethyl)phenylamino]-5"-N-ethylcarboxamidoadenosine (CGS21680) inhibits LPS-induced IL-6 release. 2-[4-(2-p-carboxyethyl)phenylamino]-5"-n-ethylcarboxamidoadenosine 108-174 interleukin 6 Homo sapiens 207-211 18229608-4 2007 In culture supernatants of TNF-alpha-stimulated HaCaT cells, production of IL-6 and TNF-alpha could be enhanced by lithium carbonate; production of IL-6 and a panel of cytokines and growth factors could be enhanced by propranolol hydrochloride; and IL-6 was up-regulated by chloroquine diphosphate as well. Propranolol 218-243 interleukin 6 Homo sapiens 148-152 18229608-4 2007 In culture supernatants of TNF-alpha-stimulated HaCaT cells, production of IL-6 and TNF-alpha could be enhanced by lithium carbonate; production of IL-6 and a panel of cytokines and growth factors could be enhanced by propranolol hydrochloride; and IL-6 was up-regulated by chloroquine diphosphate as well. Propranolol 218-243 interleukin 6 Homo sapiens 148-152 18229608-6 2007 Compared with HaCaT cells cultured with medium alone, propranolol hydrochloride at the concentration of 1 x 10(-6) mol x L(-1) could stimulate HaCaT cells to express higher level of IL-6 mRNA (P < 0.05). Propranolol 54-79 interleukin 6 Homo sapiens 182-186 19908944-7 2009 These results suggest that MET regulates ceramide metabolism in prostate PC3 cells which is involved in cell death as well as in IL-6 secretion. Ceramides 41-49 interleukin 6 Homo sapiens 129-133 33396644-7 2020 In response to LPS stimulation, the gene expression levels of IL-6 and IL-8 in hGFs increased due to AZM in a concentration-dependent manner, and phosphorylation of nuclear factor kappa B (NF-kappaB) was also promoted. Azithromycin 101-104 interleukin 6 Homo sapiens 62-66 19740321-9 2009 Poly(I:C) induced a small increase in IL-1beta, IL-6 and IL-8 production in HNECs, while Pam(3)CSK(4) increased viability. Poly I-C 0-8 interleukin 6 Homo sapiens 48-52 17876544-10 2007 Inhibitors for ERK (PD98059 and U0216) and p38 MAPK (SB203580) significantly reduced the IL-17F-induced IL-6, IL-8, LIF, MMP-1, and MMP-3 secretion. SB 203580 53-61 interleukin 6 Homo sapiens 104-108 33396644-10 2020 Thus, AZM may increase the expression of IL-6 and IL-8 under LPS stimulation to modify the inflammatory response and increase the expression of MMP-1 to promote connective tissue remodeling. Azithromycin 6-9 interleukin 6 Homo sapiens 41-45 18073617-10 2007 Survival in the AET treatment group was associated with reduced levels of IL-6, IL-10, and IL-18, and enhanced IFN-gamma and IL-2 levels. beta-Aminoethyl Isothiourea 16-19 interleukin 6 Homo sapiens 74-78 19655189-6 2009 10 mcirog/ml of TRF and all tocotrienol isoforms significantly inhibited the production of interleukin-6 and nitric oxide. Thyrotropin-Releasing Hormone 16-19 interleukin 6 Homo sapiens 91-104 33218476-2 2020 Herein, an immunosensor has been developed for monitoring IL-6, which is fabricated by Au nanoparticles (Au NPs)-thionine (THI)-carboxylated multi walled carbon nanotubes (CMWCNTs) as the substrate with high conductivity. Gold 87-89 interleukin 6 Homo sapiens 58-62 19523965-5 2009 Repetitive adult exposure to the NMDA-R antagonist ketamine increases the levels of the proinflammatory cytokine interleukin-6 in brain which, through activation of the superoxide-producing enzyme NADPH oxidase (Nox2), leads to the loss of the GABAergic phenotype of PV-interneurons and to decreased inhibitory activity in prefrontal cortex. N-Methylaspartate 33-37 interleukin 6 Homo sapiens 113-126 17537833-0 2007 Interleukin-6 alters the cellular responsiveness to clopidogrel, irinotecan, and oseltamivir by suppressing the expression of carboxylesterases HCE1 and HCE2. Oseltamivir 81-92 interleukin 6 Homo sapiens 0-13 33354576-0 2020 Tangeretin Inhibition of High-Glucose-Induced IL-1beta, IL-6, TGF-beta1, and VEGF Expression in Human RPE Cells. tangeretin 0-10 interleukin 6 Homo sapiens 56-60 17569118-7 2007 Propionate dose-dependently suppressed IL-6 mRNA and protein release from colon organ cultures and comparative studies revealed that propionate and butyrate at 30 mmol/L caused a strong inhibition of immune-related gene expression, whereas acetate was less effective. Butyrates 148-156 interleukin 6 Homo sapiens 39-43 17321112-0 2007 Sphingosylphosphorylcholine-induced interleukin-6 production is mediated by protein kinase C and p42/44 extracellular signal-regulated kinase in human dermal fibroblasts. sphingosine phosphorylcholine 0-27 interleukin 6 Homo sapiens 36-49 17321112-8 2007 Pretreatment with PD 98059, a specific MAPK kinase 1/2 inhibitor, markedly suppressed SPC-induced IL-6 expression in a dose-dependent manner. sphingosine phosphorylcholine 86-89 interleukin 6 Homo sapiens 98-102 19409914-2 2009 We examined the effect of 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) on periodontitis by inhibiting the production of interleukin-6 (IL-6). 15-deoxy-delta(12,14)-prostaglandin j 26-63 interleukin 6 Homo sapiens 129-142 19409914-2 2009 We examined the effect of 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) on periodontitis by inhibiting the production of interleukin-6 (IL-6). 15-deoxy-delta(12,14)-prostaglandin j 26-63 interleukin 6 Homo sapiens 144-148 33354576-4 2020 Our results illustrated that HG levels induced IL-1beta, IL-6, TGF-beta1, and VEGF expression and that tangeretin significantly reduced HG-induced IL-1beta, IL-6, TGF-beta1, and VEGF expression in human RPE cells. Mercury 29-31 interleukin 6 Homo sapiens 57-61 17341596-3 2007 We found that C-type natriuretic peptide and the NO donor Deta-NONOate induced IL-6 mRNA expression in primary human osteoblasts, an effect mimicked by the membrane-permeable cGMP analog 8-chlorophenylthio-cGMP (8-CPT-cGMP). 2,2'-(hydroxynitrosohydrazono)bis-ethanamine 58-70 interleukin 6 Homo sapiens 79-83 33354576-4 2020 Our results illustrated that HG levels induced IL-1beta, IL-6, TGF-beta1, and VEGF expression and that tangeretin significantly reduced HG-induced IL-1beta, IL-6, TGF-beta1, and VEGF expression in human RPE cells. tangeretin 103-113 interleukin 6 Homo sapiens 157-161 19279008-6 2009 On the other hand, increasing cellular ceramide with cell-permeable ceramide treatment resulted in attenuation of the IL-6 response. Ceramides 39-47 interleukin 6 Homo sapiens 118-122 33132165-8 2020 Finally, we showed that PNU-120596 suppressed LPS-induced phosphorylation of p38 MAPK and expression of inflammatory factors including TNF-alpha, IL-6 and COX-2, independent on alpha7 nAChR activity in microglial cell BV-2. 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea 24-34 interleukin 6 Homo sapiens 146-150 19279008-6 2009 On the other hand, increasing cellular ceramide with cell-permeable ceramide treatment resulted in attenuation of the IL-6 response. Ceramides 68-76 interleukin 6 Homo sapiens 118-122 19279008-9 2009 Thus, the GBA1-ceramide pathway is suggested to play an important role in terminating p38delta activation responsible for IL-6 biosynthesis. Ceramides 15-23 interleukin 6 Homo sapiens 122-126 17196171-5 2007 Furthermore, IL-6 secretion by PC-3 and DU145 cells was significantly suppressed by SAPKs inhibitor, especially by p38MAPK inhibitor SB203580, but not by JNK inhibitor SP600125 nor by MEK inhibitor, PD98059. SB 203580 133-141 interleukin 6 Homo sapiens 13-17 19434815-0 2009 Treatment with levamisole and colchicine can result in a significant reduction of IL-6, IL-8 or TNF-alpha level in patients with mucocutaneous type of Behcet"s disease. Levamisole 15-25 interleukin 6 Homo sapiens 82-86 32790648-5 2020 In our in vitro model, MitoDAMP-treated PBMCs secreted IL-6 that impaired mitochondrial respiration by reducing complex I activity. mitodamp 23-31 interleukin 6 Homo sapiens 55-59 19296424-10 2009 RESULTS: A reduction of TNF-alpha-induced IL-6 release after treatment with hyaluronic acid and chondroitin sulfate was observed, indicating the anti-inflammatory action of the preparation. Chondroitin Sulfates 96-115 interleukin 6 Homo sapiens 42-46 17173546-6 2007 In bone marrow stromal cells (BMSC), BIRB 796 inhibited phosphorylation of p38 MAPK and secretion of interleukin-6 (IL-6) and vascular endothelial growth factor triggered by either tumour necrosis factor-alpha or tumour growth factor-beta1. doramapimod 37-45 interleukin 6 Homo sapiens 101-114 17173546-6 2007 In bone marrow stromal cells (BMSC), BIRB 796 inhibited phosphorylation of p38 MAPK and secretion of interleukin-6 (IL-6) and vascular endothelial growth factor triggered by either tumour necrosis factor-alpha or tumour growth factor-beta1. doramapimod 37-45 interleukin 6 Homo sapiens 116-120 17173546-7 2007 BIRB 796 also inhibited IL-6 secretion induced in BMSCs by adherence to MM cells, thereby inhibiting tumour cell proliferation. doramapimod 0-8 interleukin 6 Homo sapiens 24-28 33222465-7 2020 Similarly,4-Octyl Itaconate inhibited the secretion of inflammatory cytokines (TNF-alpha, IL-1beta, IL6, and IL-8) by MCs, which was induced by LPS, but SIRT4 knockdown decreases the inhibition of 4-Octyl Itaconate. 4-Octyl Itaconate 10-27 interleukin 6 Homo sapiens 100-103 17043099-4 2007 RESULTS: Polyriboinosinic:polyribocytidylic acid (poly I:C), a synthetic dsRNA that antagonizes TLR3, stimulated the secretion of IL-6, IL-8 and GCP-2 by OECs. Poly I-C 9-48 interleukin 6 Homo sapiens 130-134 17043099-4 2007 RESULTS: Polyriboinosinic:polyribocytidylic acid (poly I:C), a synthetic dsRNA that antagonizes TLR3, stimulated the secretion of IL-6, IL-8 and GCP-2 by OECs. Poly I-C 50-58 interleukin 6 Homo sapiens 130-134 18825409-9 2009 Pretreatment of cells with SB203580 (inhibitor of p38) and PD98059 (inhibitor of ERK) attenuated LPS-induced IL-6 expression, whereas LY294002 (inhibitor of PI3K) markedly amplified the LPS-stimulated synthesis of IL-6. SB 203580 27-35 interleukin 6 Homo sapiens 109-113 18825409-9 2009 Pretreatment of cells with SB203580 (inhibitor of p38) and PD98059 (inhibitor of ERK) attenuated LPS-induced IL-6 expression, whereas LY294002 (inhibitor of PI3K) markedly amplified the LPS-stimulated synthesis of IL-6. SB 203580 27-35 interleukin 6 Homo sapiens 214-218 19249598-0 2009 Neodymium-doped yttrium-aluminium-garnet laser irradiation abolishes the increase in interleukin-6 levels caused by peptidoglycan through the p38 mitogen-activated protein kinase pathway in human pulp cells. Yttrium 16-23 interleukin 6 Homo sapiens 85-98 33192537-6 2020 Results: HG and glucosamine upregulated OGT mRNA and protein expression, protein O-GlcNAcylation, and IL-6 mRNA and protein expression. Mercury 9-11 interleukin 6 Homo sapiens 102-106 19175577-10 2009 Only IL-6 was significantly higher in the LPS Propofol(sulfite) group compared with both the Ket/Mid group and the Propofol(EDTA) group. Propofol 46-54 interleukin 6 Homo sapiens 5-9 17079650-4 2007 Thimerosal, in a concentration-dependent manner, inhibited the secretion of LPS-induced proinflammatory cytokines TNF-alpha, IL-6, and IL-12p70 from human monocyte-derived DC. Thimerosal 0-10 interleukin 6 Homo sapiens 125-129 17079650-7 2007 Thimerosal exposure of DC led to the depletion of intracellular glutathione (GSH), and addition of exogenous GSH to DC abolished the TH2-promoting effect of thimerosal-treated DC, restoring secretion of TNF-alpha, IL-6, and IL-12p70 by DC and IFN-gamma secretion by T cells. Thimerosal 0-10 interleukin 6 Homo sapiens 214-218 17079650-7 2007 Thimerosal exposure of DC led to the depletion of intracellular glutathione (GSH), and addition of exogenous GSH to DC abolished the TH2-promoting effect of thimerosal-treated DC, restoring secretion of TNF-alpha, IL-6, and IL-12p70 by DC and IFN-gamma secretion by T cells. Thimerosal 157-167 interleukin 6 Homo sapiens 214-218 19061939-3 2009 We previously indicated that exogenous IL-6 protected neurons against glutamate and N-methyl-d-aspartate (NMDA) attacks and the effects of IL-6 was blocked by anti-gp130 antibody. N-Methylaspartate 84-104 interleukin 6 Homo sapiens 39-43 19061939-3 2009 We previously indicated that exogenous IL-6 protected neurons against glutamate and N-methyl-d-aspartate (NMDA) attacks and the effects of IL-6 was blocked by anti-gp130 antibody. N-Methylaspartate 106-110 interleukin 6 Homo sapiens 39-43 19061939-8 2009 The chronic IL-6 exposure prevented the suppression of the neuronal vitality and the enhancement of the cleaved caspase-3 level induced by NMDA. N-Methylaspartate 139-143 interleukin 6 Homo sapiens 12-16 19061939-11 2009 Either AG490 or PD98059 blocked the IL-6 protection against the NMDA-elicited neuronal vitality decrease and caspase-3 activation increase. N-Methylaspartate 64-68 interleukin 6 Homo sapiens 36-40 19061939-12 2009 These findings suggest that IL-6 protects neurons from NMDA-induced excitoxicity and the IL-6 neuroprotection may be transduced by both JAK/STAT3 and RAS/MAPK pathways. N-Methylaspartate 55-59 interleukin 6 Homo sapiens 28-32 17849265-5 2007 When added to MG-63 cells, IL-6 stimulated the production of cathepsin B, which was reduced significantly by the addition of SB203580, a specific p38 MAPK inhibitor. SB 203580 125-133 interleukin 6 Homo sapiens 27-31 17849265-10 2007 Moreover, IL-6 increased the activity of urokinase type plasminogen activator (uPA) in MG-63 cells, which was inhibited by SB203580, PDTC and NF-kappaB SN50. SB 203580 123-131 interleukin 6 Homo sapiens 10-14 33192537-6 2020 Results: HG and glucosamine upregulated OGT mRNA and protein expression, protein O-GlcNAcylation, and IL-6 mRNA and protein expression. Glucosamine 16-27 interleukin 6 Homo sapiens 102-106 18502114-0 2008 An interleukin-6 ZnO/SiO(2)/Si surface acoustic wave biosensor. Silicon 21-23 interleukin 6 Homo sapiens 3-16 33057107-5 2020 MDP water extract significantly inhibited the activation of NF-kappaB and IRF reporters, downstream signaling pathways and the production of IL-6 and TNF-alpha, in a dose-dependent manner. Acetylmuramyl-Alanyl-Isoglutamine 0-3 interleukin 6 Homo sapiens 141-145 18502114-1 2008 A novel high sensitivity ZnO/SiO(2)/Si Love mode surface acoustic wave (SAW) biosensor for the detection of interleukin-6 (IL-6), is reported. Silicon 29-31 interleukin 6 Homo sapiens 108-121 18502114-1 2008 A novel high sensitivity ZnO/SiO(2)/Si Love mode surface acoustic wave (SAW) biosensor for the detection of interleukin-6 (IL-6), is reported. Silicon 29-31 interleukin 6 Homo sapiens 123-127 18660424-7 2008 RESULTS: Poly(I:C) induced the up-regulation of TLR3, the release of IL-6, IL-8, G-CSF, MIP-1beta, eotaxin, and RANTES, and the expression of ICAM-1 and VCAM-1 in corneal fibroblasts. Poly I-C 9-17 interleukin 6 Homo sapiens 69-73 16989825-0 2006 Decreased suppression of interleukin-6 after treatment with medroxyprogesterone acetate and danazol in endometrial stromal cells of women with adenomyosis. Danazol 92-99 interleukin 6 Homo sapiens 25-38 16989825-7 2006 RESULT(S): A significant decrease of IL-6 concentration in the supernatant, measured by ELISA, was found with time of ESCs cultured with MPA and danazol in the control group, but not in adenomyosis. Danazol 145-152 interleukin 6 Homo sapiens 37-41 16989825-8 2006 The IL-6 mRNA in ESCs determined by real-time quantitative polymerase chain, as well as its concentration in the supernatant, was much higher in adenomyosis than that in the control group after treatment with MPA and danazol for 8 days. Danazol 217-224 interleukin 6 Homo sapiens 4-8 16989825-9 2006 CONCLUSION(S): Medroxyprogesterone acetate and danazol appeared to have a decreased effect on the suppression of IL-6 liberated by ESCs in adenomyosis. Danazol 47-54 interleukin 6 Homo sapiens 113-117 32703116-15 2020 Regarding cytokine analysis, a negative correlation between daily caffeine consumption and serum level of IFNgamma was found (p = 0.03, r = -0.2); furthermore, patients with a high intake of caffeine showed lower serum levels of IFNalpha (p = 0.02), IL-17 (p = 0.01) and IL-6 (p = 0.003). Caffeine 191-199 interleukin 6 Homo sapiens 271-275 16954375-9 2006 Similarly, the proteasome inhibitor MG132 stabilized interleukin-6 mRNA probably through an increase of AUF1 levels. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 36-41 interleukin 6 Homo sapiens 53-66 19669308-8 2008 In contrast, transfection of HIBECs with polyI:C induced a marked increase in mRNAs encoding a variety of chemokines/cytokines, including IFN-beta, IL-6, and TNF-alpha. Poly I-C 41-48 interleukin 6 Homo sapiens 148-152 33164356-4 2020 The results showed that adenosine, epigoitrin, chlorogenic acid, caffeic acid, cichoric acid, corynoline, baicalin, wogonoside, wogonin and oroxylin A had a certain regulatory effect on inflammatory factor tumor necrosis factor(TNF-alpha), interleukin(IL-1beta) and IL-6 at specific concentrations in a dose-dependent manner. goitrin 35-45 interleukin 6 Homo sapiens 266-270 17020997-2 2006 EXPERIMENTAL DESIGN: Growth-inhibitory effect of MLN120B in multiple myeloma cells in the presence of cytokines [interleukin-6 (IL-6) and insulin-like growth factor-I (IGF-1)], conventional agents (dexamethasone, melphalan, and doxorubicin), or BMSC was assessed in vitro. N-(6-chloro-7-methoxy-9H-beta-carbolin-8-yl)-2-methylnicotinamide 49-56 interleukin 6 Homo sapiens 113-126 33164356-4 2020 The results showed that adenosine, epigoitrin, chlorogenic acid, caffeic acid, cichoric acid, corynoline, baicalin, wogonoside, wogonin and oroxylin A had a certain regulatory effect on inflammatory factor tumor necrosis factor(TNF-alpha), interleukin(IL-1beta) and IL-6 at specific concentrations in a dose-dependent manner. wogonin 128-135 interleukin 6 Homo sapiens 266-270 30765608-10 2020 On the other hand, a significant negative association was found between LFE dietary pattern and serum concentrations of IL-6 (p=0.01) and TNF-alpha (p=0.02). LFE 72-75 interleukin 6 Homo sapiens 120-124 16978071-4 2006 Carbohydate compared with placebo ingestion attenuated exercise-induced changes in plasma cortisol (8.8% vs. 62%, respectively), epinephrine (-9.2% vs. 138%), IL-6 (10-fold vs. 40-fold), IL-10 (8.9-fold vs. 26-fold, and IL-1Ra (2.1-fold vs. 5.6-fold). carbohydate 0-11 interleukin 6 Homo sapiens 159-163 16949834-0 2006 Thyroxine replacement dose in patients with Hashimoto disease: a potential role for interleukin-6. Thyroxine 0-9 interleukin 6 Homo sapiens 84-97 16949834-4 2006 RESULTS: Serum IL-6 showed a significant positive correlation both with total thyroxine replacement dose (r=0.551, p=0.001) and with dose per kilogram of body weight (r=0.482, p=0.002). Thyroxine 78-87 interleukin 6 Homo sapiens 15-19 18093851-6 2008 SB-203580 caused dose-dependent decreases in cytokine protein expression and decreased IL-6 and IL-11 mRNA expression. SB 203580 0-9 interleukin 6 Homo sapiens 87-91 18034171-4 2008 9(S)-HODE evoked intracellular calcium mobilization and secretion of cytokines, including IL-6, IL-8, and GM-CSF in NHEK cells. 9(S)-HODE 0-9 interleukin 6 Homo sapiens 90-94 16949834-8 2006 CONCLUSIONS: In patients with Hashimoto disease serum IL-6 levels are positively associated with thyroxine replacement dose and negatively associated with T(3) and T(3)/T(4) ratio. Thyroxine 97-106 interleukin 6 Homo sapiens 54-58 30765608-12 2020 CONCLUSION: Adherence to VEG and LFE dietary patterns was inversely and directly associated to serum IL-6 and TNF-alpha concentrations in shift workers, respectively. LFE 33-36 interleukin 6 Homo sapiens 101-105 16949834-9 2006 These results are possibly attributable to the inhibitory effect of IL6 on deiodination of T(3) and imply a role for IL6 in determining thyroxine replacement dose among these patients. Thyroxine 136-145 interleukin 6 Homo sapiens 117-120 33083327-8 2020 Results: Mercury-exposed citizens, especially those with hypertension, had significantly higher concentrations of inflammatory cytokines TNF-alpha, IL-2, IL-6 and anti-inflammatory cytokine IL-10 as compared to the unexposed population. Mercury 9-16 interleukin 6 Homo sapiens 154-158 16797970-3 2006 For many years, the cytokine interleukin-6 (IL-6) was considered a central growth factor and was thus believed to play a pivitol role in the pathogenesis of MM. pivitol 121-128 interleukin 6 Homo sapiens 29-42 18281277-2 2008 Exposure of cells to the saturated fatty acid palmitate led to enhanced diacylglycerol levels and the consequent activation of the protein kinase C/nuclear factor kappaB pathway, finally resulting in enhanced interleukin 6 secretion and down-regulation of the expression of genes involved in the control of the oxidative capacity of skeletal muscle (peroxisome proliferator-activated receptor (PPAR)gamma-coactivator 1alpha) and triglyceride synthesis (acyl-coenzyme A: diacylglycerol acyltransferase 2). saturated fatty acid palmitate 25-55 interleukin 6 Homo sapiens 209-222 18177344-6 2008 However, p38 inhibitor SB203580 abrogated TNF-alpha, IL-1beta and IL-6 production. SB 203580 23-31 interleukin 6 Homo sapiens 66-70 16797970-3 2006 For many years, the cytokine interleukin-6 (IL-6) was considered a central growth factor and was thus believed to play a pivitol role in the pathogenesis of MM. pivitol 121-128 interleukin 6 Homo sapiens 44-48 32467994-9 2020 Moreover, HG treatment induced inflammation by upregulating tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-6 expression. Mercury 10-12 interleukin 6 Homo sapiens 116-120 16757516-5 2006 The thiol N-acetyl-L-cysteine, the micronutrient selenite as well as selenoprotein P and the lipid peroxidation inhibitors alpha-tocopherol and butylated hydroxytoluene significantly lower both the number of TGFbeta1-initiated myofibroblasts and the secretion of HGF, VEGF and IL-6, correlating with a diminished invasive capacity of tumor cells. Butylated Hydroxytoluene 144-168 interleukin 6 Homo sapiens 277-281 18279739-6 2008 RESULTS: Ramipril improved endothelial function (p < 0.001) and decreased the expression of proinflammatory cytokine IL-6 (p < 0.05) and sCD40L (p < 0.01). Ramipril 9-17 interleukin 6 Homo sapiens 120-124 18279739-9 2008 CONCLUSIONS: Ramipril reversed the impaired endothelial function and decreased the expression of proinflammatory cytokine IL-6, sCD40L, and adhesion molecules in normotensive subjects with SCR. Ramipril 13-21 interleukin 6 Homo sapiens 122-126 32653044-10 2020 Prior to addition of XOI, treatment with colchicine alone resulted in smaller numerical improvements in FMD, hsCRP, and ESR (20.7%, 8.9%, 13% reductions, respectively; all non-significant), but not IL-1beta or IL-6. Colchicine 41-51 interleukin 6 Homo sapiens 210-214 17621267-4 2008 The expression of the methyltransferases DNA methyltransferase enzyme-1 and HASJ4442 was increased by IL-6 overexpression, but was decreased by the methylation inhibitor 5-aza-2"-deoxycytidine (5-aza-CdR). Decitabine 170-192 interleukin 6 Homo sapiens 102-106 16399790-6 2006 Additionally, preexposure to DE(as) significantly increased the poly(I:C)-induced expression of IL-6. Poly I-C 64-73 interleukin 6 Homo sapiens 96-100 32115640-12 2020 Emodin also displayed notable effects on pathology, TLR3 protein in brain tissues, and expression of IL-6, NF-kappaB, IFN-beta, in serum. Emodin 0-6 interleukin 6 Homo sapiens 101-105 20085228-3 2006 The results of in vitro cytotoxic activity of the mixture of spirostanol saponins against cell lines melanoma B16 and sarcoma XC and human fibroblasts HSF are also reported. Saponins 73-81 interleukin 6 Homo sapiens 151-154 16532021-6 2006 The p38 inhibitor SB203580 and the PKC inhibitors Calphostin C and Go6976 completely inhibited IL-1-induced IL-6 production. SB 203580 18-26 interleukin 6 Homo sapiens 108-112 18510246-13 2008 These inhibitory effects were significant at both the mRNA and protein levels (protein of IL-6: t1h = 7.9154, t2h = 10.863, t4h = 8.2451, t8h = 13.5063. protein of IL-8: t1h = 8.5663, t2h = 20.5169, t4h = 25.1580, t8h = 34.8699. mRNA of IL-6: t1h = 12.0235, t2h = 13.2894, t4h = 24.0799, t8h = 27.2261. mRNA of IL-8: t1h = 20.9424, t2h = 24.1314, t4h = 29.8580, t8h = 47.9442. 2-[4-[[(~{E})-~{N},~{N}'-dimethylcarbamimidoyl]amino]piperidin-1-yl]-~{N}-[[2-(3-methyl-1,2,3-triazol-4-yl)-1~{H}-benzimidazol-5-yl]methyl]ethanamide 96-99 interleukin 6 Homo sapiens 90-94 18306624-8 2007 The increasing trend of IL-6 and IL-10 levels were similar in both groups, whereas the level of IL-6 at T1 in propofol group was lower than that of isoflurane group significantly (P < 0.01), however the level of IL-10 was much higher in propofol group than that of isoflurane group at T1 and T2 (P < 0.05). Propofol 240-248 interleukin 6 Homo sapiens 96-100 16641887-1 2006 Pyruvic acid, an intermediate metabolite of glucose, an effective scavenger of reactive oxygen species (ROS), inhibits tumor necrosis factor-alpha production and NF-kappaB signaling pathways, reduces circulating levels of HMGB1 (high mobility group B1), decreases COX-2 (cyclo-oxygenase-2), iNOS (inducible nitric oxide synthase), and IL-6 (interleukin-6) mRNA expression in liver, ileal mucosa, and colonic mucosa in animal models with endotoxemia. Pyruvic Acid 0-12 interleukin 6 Homo sapiens 335-339 32141941-6 2020 RESULTS: Pretreatment with 10 M DHT or 17-beta-estradiol inhibited the high osmolarity-induced expression of TNF-alpha, IL-8, and IL-6. Dihydrotestosterone 32-35 interleukin 6 Homo sapiens 130-134 16641887-1 2006 Pyruvic acid, an intermediate metabolite of glucose, an effective scavenger of reactive oxygen species (ROS), inhibits tumor necrosis factor-alpha production and NF-kappaB signaling pathways, reduces circulating levels of HMGB1 (high mobility group B1), decreases COX-2 (cyclo-oxygenase-2), iNOS (inducible nitric oxide synthase), and IL-6 (interleukin-6) mRNA expression in liver, ileal mucosa, and colonic mucosa in animal models with endotoxemia. Pyruvic Acid 0-12 interleukin 6 Homo sapiens 341-354 16572448-8 2006 When hemoglobin, as a scavenger of carbon monoxide, was added to auranofin-treated synovial cell lines, LPS-dependent production of IL-6 and IL-8 was increased. Carbon Monoxide 35-50 interleukin 6 Homo sapiens 132-136 18029320-8 2007 IL-6, IL-10, lactate, and base excess levels in the THS group were significantly higher than those in the PHS and healthy control groups. THYMIDINE-5'-(DITHIO)PHOSPHATE 52-55 interleukin 6 Homo sapiens 0-4 32595791-6 2020 Ex vivo culture of human AAA tissue was utilized to evaluate the effect of P505-15, a Syk inhibitor, on secretions of interleukin-6 (IL-6) and matrix metalloproteinases (MMPs). 4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-(2-aminocyclohexylamino)pyrimidine-5-carboxamide 75-82 interleukin 6 Homo sapiens 118-131 17617628-5 2007 MC(TC) cells with IgE-enhanced Fc epsilonRI levels were more sensitive to stimulation with a low dose of anti-Fc epsilonRI mAb in terms of degranulation and production of PGD(2), GM-CSF, IL-6, IL-13, and TNF-alpha. Methylcholanthrene 0-2 interleukin 6 Homo sapiens 187-191 16595893-8 2006 Finally, the addition of TNF-alpha significantly increased IL-6 protein production, which was suppressed by the addition of pitavastatin. pitavastatin 124-136 interleukin 6 Homo sapiens 59-63 16595893-9 2006 These results suggest that pitavastatin at a low dose (0.1 microM) inhibits NF-kappaB activation and decreases IL-6 production induced by TNF-alpha, and is therefore expected to be a new strategy for treating HCC. pitavastatin 27-39 interleukin 6 Homo sapiens 111-115 32595791-6 2020 Ex vivo culture of human AAA tissue was utilized to evaluate the effect of P505-15, a Syk inhibitor, on secretions of interleukin-6 (IL-6) and matrix metalloproteinases (MMPs). 4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-(2-aminocyclohexylamino)pyrimidine-5-carboxamide 75-82 interleukin 6 Homo sapiens 133-137 17637508-11 2007 AG490 as well as SB 203580 and parthenolide blocked CT-1 induced IL-6 expression completely. SB 203580 17-26 interleukin 6 Homo sapiens 65-69 31822346-13 2020 CONCLUSION: UPM induces the expression of IL-6, CXCL1, IL-1beta, and TNF-alpha in nasal fibroblasts and this effect is reversed by FP via the STAT3 and NF-kappaB signalling pathways. fp 131-133 interleukin 6 Homo sapiens 42-46 17464423-5 2007 Meanwhile, our data showed that interleukin-6 (IL-6) (100 ng/mL) could also inhibited the cell growth of BEL-7402. bel-7402 105-113 interleukin 6 Homo sapiens 32-45 15917303-5 2005 Pretreatment with the pharmacological inhibitors of p38 MAPK SB-203580 or SB-202190 blocked IL-6-induced SGK phosphorylation at Ser78 and SGK activation. SB 203580 61-70 interleukin 6 Homo sapiens 92-96 15923319-6 2005 Gene expression of TNF-alpha, IL-6, and IL-10 was markedly enhanced by epinephrine in EMCV-inoculated mice. Epinephrine 71-82 interleukin 6 Homo sapiens 30-34 15923319-9 2005 Propranolol also suppressed gene expression of TNF-alpha, IL-6, and IL-10. Propranolol 0-11 interleukin 6 Homo sapiens 58-62 17464423-5 2007 Meanwhile, our data showed that interleukin-6 (IL-6) (100 ng/mL) could also inhibited the cell growth of BEL-7402. bel-7402 105-113 interleukin 6 Homo sapiens 47-51 17464423-8 2007 The present results demonstrate that TIMP-1 may be one of the mediators that regulate the inhibitory effect of IL-6 on BEL-7402 proliferation in which STAT3 signal transduction and p21 up-regulation also play important roles. bel-7402 119-127 interleukin 6 Homo sapiens 111-115 32234671-5 2020 The results revealed that CCGA dose-dependently inhibited LPS-induced production of NO, TNF-alpha, and IL-6 and blocked iNOS, COX-2, TNF-alpha, and IL-6 expressions. ccga 26-30 interleukin 6 Homo sapiens 103-107 20409851-10 2007 IL-6, IL-18, sICAM, and MCP-1 levels were reduced by valsartan (three-fold, P < .05). Valsartan 53-62 interleukin 6 Homo sapiens 0-4 15940250-3 2005 Here, we show that IL-6 together with FGF enhanced proliferation of a myeloma cell line, KMS-11 carrying t(4;14)(p16.3;q32) and the FGFR 3-transfected U 266 myeloma cell line which ectopically expressed FGFR 3 but responded to neither IL-6 nor FGF alone. kms-11 89-95 interleukin 6 Homo sapiens 19-23 32234671-5 2020 The results revealed that CCGA dose-dependently inhibited LPS-induced production of NO, TNF-alpha, and IL-6 and blocked iNOS, COX-2, TNF-alpha, and IL-6 expressions. ccga 26-30 interleukin 6 Homo sapiens 148-152 15940250-4 2005 In KMS-11, IL-6 activated signal transducer and activator of transcription 3 (STAT 3) while FGF activated extracellular signal-regulated kinase 1/2 (ERK 1/2) and phosphatidylinositol (PI)-3 kinase. kms-11 3-9 interleukin 6 Homo sapiens 11-15 15940250-5 2005 As both MEK inhibitors and a PI 3-kinase inhibitor abolished the effect of IL-6 and FGF, the activation of both the ERK 1/2 and PI 3-kinase signaling cascades is essential for the proliferation of KMS-11 enhanced by IL-6 and FGF. kms-11 197-203 interleukin 6 Homo sapiens 75-79 15940250-5 2005 As both MEK inhibitors and a PI 3-kinase inhibitor abolished the effect of IL-6 and FGF, the activation of both the ERK 1/2 and PI 3-kinase signaling cascades is essential for the proliferation of KMS-11 enhanced by IL-6 and FGF. kms-11 197-203 interleukin 6 Homo sapiens 216-220 32389805-8 2020 Cytokine release in SGCs was measured using enzyme-linked immunosorbent assays (ELISA) after oxaliplatin exposure and indicated an increased release of IL-6 and TNFalpha, while IL-1beta was decreased. Oxaliplatin 93-104 interleukin 6 Homo sapiens 152-156 15894558-8 2005 SB-203580, a p38 MAPK-specific inhibitor, inhibits IL-6-induced p38 MAPK phosphorylating activity and suppresses IL-6-stimulated cell proliferation. SB 203580 0-9 interleukin 6 Homo sapiens 51-55 17593869-0 2007 Propofol increased the interleukin-6 to interleukin-10 ratio more than isoflurane after surgery in long-term alcoholic patients. Propofol 0-8 interleukin 6 Homo sapiens 23-36 32597030-8 2020 On day 3, muscle glycogen content before exercise was negatively correlated with serum iron level (immediately after exercise, 3 hr after exercise), serum hepcidin level immediately after exercise, and plasma IL-6 level immediately after exercise (p < .05). Glycogen 17-25 interleukin 6 Homo sapiens 209-213 17650792-6 2007 After treatment, the general condition of patients was improved, the recovery time of intestinal tract function was shortened and the concentrations of C3, CRP and IL-6 significantly decreased in CTG, with the effects better than those in RTG respectively (P < 0.01 or P < 0.05). ctg 196-199 interleukin 6 Homo sapiens 164-168 15894558-8 2005 SB-203580, a p38 MAPK-specific inhibitor, inhibits IL-6-induced p38 MAPK phosphorylating activity and suppresses IL-6-stimulated cell proliferation. SB 203580 0-9 interleukin 6 Homo sapiens 113-117 16312193-12 2005 In conclusion, it appears that titanium implants activate osteocalcin production while stainless steel activates IL-6. Stainless Steel 87-102 interleukin 6 Homo sapiens 113-117 17158355-3 2007 METHODS AND RESULTS: Treatment of endothelial cells with anthocyanin prevented from CD40-induced proinflammatory status, measured by production of IL-6, IL-8, and monocyte chemoattractant protein-1 through inhibiting CD40-induced nuclear factor-kappaB (NF-kappaB) activation. Anthocyanins 57-68 interleukin 6 Homo sapiens 147-151 32017949-11 2020 RESULTS: MHF treatment reduced lung index, W/D ratios, and serum levels of inflammatory factors (IL-6, TNF-alpha, IL-1beta, PLA2, LBT4 and ICAM-1) in IAV-infected mice. monomethyl fumarate 9-12 interleukin 6 Homo sapiens 97-101 17237435-6 2007 Prednisolone dose-dependently inhibited the LPS-induced release of cytokines (TNF-alpha and IL-6) and chemokines (IL-8 and MCP-1), while enhancing the release of the anti-inflammatory cytokine IL-10. Prednisolone 0-12 interleukin 6 Homo sapiens 92-96 16003000-0 2005 Carbon monoxide inhibits IL-17-induced IL-6 production through the MAPK pathway in human pulmonary epithelial cells. Carbon Monoxide 0-15 interleukin 6 Homo sapiens 39-43 32241907-5 2020 Endogenous PAR-2 activation in submerged airway RPMI 2650 or NCI-H520 squamous cells increased intracellular calcium levels and granulocyte macrophage-colony-stimulating factor, tumor necrosis factor alpha, and interleukin (IL)-6 secretion. rpmi 48-52 interleukin 6 Homo sapiens 211-229 15989786-6 2005 CONCLUSION: RA can up-regulate the expression of C3 and Bf of A549 cells induced with TNF-alpha, IL-1beta, IL-6 and IFN-gamma, and regulate the immunological defence of local lung tissue, which provides a theoretical basis for prevention and treatment of pulmonary diseases by using RA and cytokines. Radium 12-14 interleukin 6 Homo sapiens 107-111 16126982-9 2005 IL-6 levels correlated with the leukocyte count, sIL-2r with the FQ, and ET-1 with the diffuse lung capacity for carbon monoxide. Carbon Monoxide 113-128 interleukin 6 Homo sapiens 0-4 17160716-0 2007 Phytic acid modulates in vitro IL-8 and IL-6 release from colonic epithelial cells stimulated with LPS and IL-1beta. Phytic Acid 0-11 interleukin 6 Homo sapiens 40-44 17160716-2 2007 The aim of this study was to examine the role of PA in immunologic function of intestinal epithelial cells by analyzing its effect on interleukin (IL)-8 and IL-6 secretion by colonocytes and its role in the response of these cells to bacterial lipopolysaccharides (LPS) and IL-1beta. Phytic Acid 49-51 interleukin 6 Homo sapiens 157-161 17160716-6 2007 On the contrary, PA increased constitutive IL-6 secretion and exhibited differentiated effects on LPS responsiveness of cells depending on its concentration and LPS origin. Phytic Acid 17-19 interleukin 6 Homo sapiens 43-47 17160716-7 2007 PA was also an efficient down-regulator of IL-6 secretion stimulated by binary actions of LPS and IL-1beta. Phytic Acid 0-2 interleukin 6 Homo sapiens 43-47 17160716-8 2007 The ability of PA to modulate IL-8 and IL-6 release suggests that PA present in the intestinal milieu may exert immunoregulatory effects on colonic epithelium under physiological conditions or during microbe-induced infection/inflammation in order to maintain the colonic mucosa in a noninflammatory state or to counteract infection. Phytic Acid 15-17 interleukin 6 Homo sapiens 39-43 28861755-0 2020 Clarithromycin decreases rhinovirus replication and cytokine production in nasal epithelial cells from subjects with bronchial asthma: effects on IL-6, IL-8 and IL-33. Clarithromycin 0-14 interleukin 6 Homo sapiens 146-150 17160716-8 2007 The ability of PA to modulate IL-8 and IL-6 release suggests that PA present in the intestinal milieu may exert immunoregulatory effects on colonic epithelium under physiological conditions or during microbe-induced infection/inflammation in order to maintain the colonic mucosa in a noninflammatory state or to counteract infection. Phytic Acid 66-68 interleukin 6 Homo sapiens 39-43 17241887-7 2007 Treatment with a demethylating agent, 5-aza-2"-deoxycytidine (DAC), restored IL-6 induction of SOCS-3, terminated the phospho-STAT-3 response, and reduced cellular levels of Mcl-1. Decitabine 38-60 interleukin 6 Homo sapiens 77-81 17241887-7 2007 Treatment with a demethylating agent, 5-aza-2"-deoxycytidine (DAC), restored IL-6 induction of SOCS-3, terminated the phospho-STAT-3 response, and reduced cellular levels of Mcl-1. Decitabine 62-65 interleukin 6 Homo sapiens 77-81 15948980-8 2005 In some OLP patients with the serum IL-6 or IL-8 levels higher than the upper limit of normal serum concentration, treatment with levamisole for a period of 0.5-6.0 months could significantly reduce the mean serum IL-6 level from 14.3 +/- 1.9 pg mL(-1) to 3.2 +/- 0.6 pg mL(-1) (P < 0.001) and could significantly reduce the mean serum IL-8 level from 95.8 +/- 17.1 pg mL(-1) to 14.8 +/- 5.8 pg mL(-1) (P < 0.001). Levamisole 130-140 interleukin 6 Homo sapiens 36-40 15948980-8 2005 In some OLP patients with the serum IL-6 or IL-8 levels higher than the upper limit of normal serum concentration, treatment with levamisole for a period of 0.5-6.0 months could significantly reduce the mean serum IL-6 level from 14.3 +/- 1.9 pg mL(-1) to 3.2 +/- 0.6 pg mL(-1) (P < 0.001) and could significantly reduce the mean serum IL-8 level from 95.8 +/- 17.1 pg mL(-1) to 14.8 +/- 5.8 pg mL(-1) (P < 0.001). Levamisole 130-140 interleukin 6 Homo sapiens 214-218 15948980-10 2005 Levamisole can modulate both the serum IL-6 and IL-8 levels in OLP patients. Levamisole 0-10 interleukin 6 Homo sapiens 39-43 32126500-6 2020 Results from the current study showed that pretreatment with nafithromycin significantly reduced the total cell count, total protein, MPO, TNF-alpha and IL-6 levels in BAL fluid compared to LPS control group. nafithromycin 61-74 interleukin 6 Homo sapiens 153-157 15877961-6 2005 CONCLUSION: Aloe polysaccharide could promote keratinocytes to secrete TGF-alpha, TGF-beta1, IL-1beta, IL-6, IL-8 and TNF, and inhibit the release of NO. aloe polysaccharide 12-31 interleukin 6 Homo sapiens 103-107 15630592-5 2005 We show that recombinant glucocorticoid receptor (GR) binds strongly to the AGT gene promoter when nucleoside A is present at -217, and dexamethasone treatment increases the interleukin 6 induced promoter activity of reporter constructs containing nucleoside A at -217. nucleoside a 248-260 interleukin 6 Homo sapiens 174-187 15582581-5 2005 Over the same concentration range of the nucleotide that was effective for IL-6 synthesis, ATP caused an increase in the intracellular Ca(2+) concentration ([Ca(2+)](i)), which increase was inhibited by pretreatment with suramin, a P2Y receptor antagonist, or 2-aminoethoxydiphenyl borate (2-APB), an inositol 1,4,5-trisphosphate receptor blocker, but not by the extracellular Ca(2+)-chelating agent EGTA. 2-aminoethoxydiphenyl borate 260-288 interleukin 6 Homo sapiens 75-79 15345683-11 2004 The addition of SB203580 to ionomycin decreased (P<0.05) nuclear p-p38 MAPK and totally abolished (P<0.05) the ionomycin- induced increase in IL-6 mRNA. SB 203580 16-24 interleukin 6 Homo sapiens 148-152 17261957-6 2007 Valsartan attenuated endothelial dysfunction [FMD 7.0 +/- 0.7 (t = 2 hr), 6.1 +/- 0.7 (t = 4 hr), 6.2 +/- 0.6% (t = 22 hr); P < 0.005] and decreased the release of interleukin-6 and TNF-alpha from leukocytes both before and during the clamp (P < 0.05). Valsartan 0-9 interleukin 6 Homo sapiens 167-180 17207362-4 2007 RESULTS: SB203580 obviously down-regulated the activities of p38 and cPLA(2), as well as the release of IL-1 beta and IL-6. SB 203580 9-17 interleukin 6 Homo sapiens 118-122 32344650-0 2020 The Effect of Vitamin D3 Supplementation on Hepcidin, Iron, and IL-6 Responses after a 100 km Ultra-Marathon. Cholecalciferol 14-24 interleukin 6 Homo sapiens 64-68 16581242-0 2006 Morphological and binding properties of interleukin-6 on thin ZnO films grown on (100) silicon substrates for biosensor applications. Silicon 87-94 interleukin 6 Homo sapiens 40-53 32244640-10 2020 However, SDSX16-P10 was found to cause lower levels of cytokine expression than SDSX16-P75 using real-time PCR and flow cytometry, such as IL1beta, IL6, IFN-beta, TNF-alpha, indicating that SDSX16-P10 might inhibit the expression of cytokines. sdsx16-p10 9-19 interleukin 6 Homo sapiens 148-151 17101474-4 2006 Fibroblasts pre-incubated with tirilazad at a concentration of 30 microM show significantly less IL-6 in the extracellular medium after UVA exposure. tirilazad 31-40 interleukin 6 Homo sapiens 97-101 16952593-8 2006 Taurine level in group GT was higher than in group G. Arginine and citrulline levels in groups G and GT were lower than in group C. Taurine level in the small intestine was greater in group GT than in group G. Citrulline concentration was lower in group G than in groups GT and C. Endotoxin level in portal blood and cytokine (tumor necrosis factor alpha, interleukin-1beta, and interleukin-6) levels in blood tended to be lower for group GT than for group G, but no significant differences were noted. Taurine 132-139 interleukin 6 Homo sapiens 379-392 32308723-6 2020 The results showed that 5 selected polysaccharides, except BBPS, significantly (P < 0.05) and dose-dependently increased M1 (IL-1beta + IL-6 + TNF-alpha)/M2 (IL-10) cytokine secretion ratios by macrophages in the absence of LPS, suggesting that four selected polysaccharides have M1 polarization property. Polysaccharides 35-50 interleukin 6 Homo sapiens 136-140 16765939-0 2006 Protective effects of alpha1-acid glycoprotein and serum amyloid A on concanavalin A-induced liver failure via interleukin-6 induction by ME3738. ME3738 138-144 interleukin 6 Homo sapiens 111-124 16765939-1 2006 We examined whether the 22beta-methoxyolean-12-ene-3beta,24(4beta)-diol (ME3738)-mediated selective induction of interleukin-6 increased alpha1-acid glycoprotein and serum amyloid A expression, and whether these proteins protected against liver injury in vitro and in vivo. ME3738 73-79 interleukin 6 Homo sapiens 113-126 16765939-5 2006 These results suggest that alpha1-acid glycoprotein and serum amyloid A, increased by ME3738-induced interleukin-6, might protect against concanavalin A-induced liver injury. ME3738 86-92 interleukin 6 Homo sapiens 101-114 32111036-6 2020 In addition, SP significantly suppressed the mRNA and protein levels of TNF-alpha, IL-1beta, and IL-6 in TNF-alpha-stimulated NCI-H292 cells. sp 13-15 interleukin 6 Homo sapiens 97-101 16508777-10 2006 HbA(1c) levels and the inflammatory markers IL-6 and CRP decreased with pioglitazone compared with placebo (ANCOVA: p=0.009, p=0.001 and p=0.004, respectively). Pioglitazone 72-84 interleukin 6 Homo sapiens 44-48 32010251-10 2020 Allylestrenol combined with ritodrine can significantly reduce the expression levels of IL-17, IL-10 and IL-6 in TPTL, reduce adverse pregnancy conditions, prolong gestational weeks, and has higher safety and better application value. Allylestrenol 0-13 interleukin 6 Homo sapiens 105-109 16500336-9 2006 Vitamin E increased serum interleukin-6 levels. Vitamin E 0-9 interleukin 6 Homo sapiens 26-39 31943744-10 2020 Moreover, the NF-kappaB signalling pathway inhibitor PDTC significantly inhibited poly(I:C)-induced IL-6 expression. prolinedithiocarbamate 53-57 interleukin 6 Homo sapiens 100-104 16761500-3 2006 The aim of our study was to evaluate whether monotherapy with chloroquine phosphate affects IL-1beta, IL-6, IL-18 and TNF-alpha serum levels in SLE patients. chloroquine diphosphate 62-83 interleukin 6 Homo sapiens 102-106 32713855-0 2020 Cardiac differentiation of bone-marrow-resident c-kit+ stem cells by L-carnitine increases through secretion of VEGF, IL6, IGF-1, and TGF- beta as clinical agents in cardiac regeneration. Carnitine 69-80 interleukin 6 Homo sapiens 118-121 16354411-3 2005 Licochalcone A (IC50 15.0 nM) inhibited PGE2 production, but not IL-6 and IL-8 production, in response to IL-1beta. licochalcone A 0-14 interleukin 6 Homo sapiens 65-69 32869704-0 2020 Deoxycholic Acid Upregulates the Reprogramming Factors KFL4 and OCT4 Through the IL-6/STAT3 Pathway in Esophageal Adenocarcinoma Cells. Deoxycholic Acid 0-16 interleukin 6 Homo sapiens 81-85 16405788-0 2005 [Change of the serum interleukin 6 in patients with delayed encephalopathy after acute carbon monoxide poisoning]. Carbon Monoxide 87-102 interleukin 6 Homo sapiens 21-34 16197469-7 2005 NF-kappaB inhibitor BAY 11-7082 and p38 MAPK inhibitor SB 203580 significantly decreased IL-6 release in a co-culture of BEAS-2B cells and eosinophils. SB 203580 55-64 interleukin 6 Homo sapiens 89-93 32869704-3 2020 In the present study, deoxycholic acid was used to investigate whether it could induce the expression of reprogramming factors Kruppel-like factor, OCT4, and Nanog; the transformation to cancer stem cells in esophageal adenocarcinoma; and the involvement of the interleukin-6/signal transduction and activation of transcription 3 inflammatory signaling pathway. Deoxycholic Acid 22-38 interleukin 6 Homo sapiens 262-275 16228299-7 2005 2-Aminoethoxydiphenyl borate (APB), a blocker of store-operated calcium channels (SOCs), and bisindolylmaleimide I (Bis I), a broad-spectrum protein kinase C (PKC) inhibitor, inhibited the basal and synergic effects of IL-6 secretion in response to calcium-mobilizing agents and TNF-alpha, but did not prevent the abrogated effect of RANTES secretion. 2-aminoethoxydiphenyl borate 0-28 interleukin 6 Homo sapiens 219-223 32869704-7 2020 Results showed that deoxycholic acid promotes the expression of reprogramming factors Kruppel-like factor and OCT4, which are regulated by the interleukin-6/signal transduction and activation of transcription 3 signaling pathway. Deoxycholic Acid 20-36 interleukin 6 Homo sapiens 143-156 15913932-6 2005 SB203580 inhibited the expression of IL-6 mRNA. SB 203580 0-8 interleukin 6 Homo sapiens 37-41 31888640-7 2019 RESULTS: Ticagrelor and clopidogrel can inhibit the degradation of IKBalpha and phosphorylation of p65, prevent p65 from entering the nucleus, reduce the production of TNFalpha, IL-1, IL-8, IL-6 and IL-2, and alleviate the decrease in cell viability, cell migration and angiogenesis, the changes of cell cycle and apoptosis induced by LPS. Ticagrelor 9-19 interleukin 6 Homo sapiens 190-194 16085044-6 2005 There was a stepwise reduction of TNF-alpha (23.6-97.5% reduction) and IL-6 (13.7-71% reduction) with increasing doses of betamethasone and methyl-prednisolone from placentas of women with preeclampsia and normal pregnancy. Betamethasone 122-135 interleukin 6 Homo sapiens 71-75 31955536-1 2019 OBJECTIVE: To study the effects of tetrahydroxy stilbene-2-O-beta-D-glucoside (TSG) on stress-induced premature senescence of human skin fibroblasts (HSF) exposed to ultraviolet radiation B (UVB) and its possible mechanism. 3,3',4,5'-tetrahydroxystilbene 35-77 interleukin 6 Homo sapiens 150-153 16185416-4 2005 The effect of different concentrations of PGG on the release of TNF-alpha and hIL-6 from LPS-stimulated hPBMC were measured by ELISA method. pgg 42-45 interleukin 6 Homo sapiens 78-83 16185416-8 2005 The release of TNF-alpha and IL-6 of hPBMC under LPS stimulation (958 +/- 234 ng/L vs 1 351 +/- 99 ng/L) was obviously inhibited by PGG in the concentration of higher than 20 mg/L compared with that without PGG treatment (1 788 +/- 171 ng/L vs 1 965 +/- 232 ng/L, P < 0.05). pgg 132-135 interleukin 6 Homo sapiens 29-33 16185416-8 2005 The release of TNF-alpha and IL-6 of hPBMC under LPS stimulation (958 +/- 234 ng/L vs 1 351 +/- 99 ng/L) was obviously inhibited by PGG in the concentration of higher than 20 mg/L compared with that without PGG treatment (1 788 +/- 171 ng/L vs 1 965 +/- 232 ng/L, P < 0.05). pgg 207-210 interleukin 6 Homo sapiens 29-33 31738650-5 2021 When these LPS + LBP-stimulated cells were exposed to DHT for 2 days, it was found that DHT suppressed the secretion of IL-6, IL-10, IL-1beta, VEGF-A cytokines in corneal epithelial cells; TNF-alpha, IL-6, IL-1beta, VEGF-A cytokines in conjunctival epithelial cells; and IL-6, IL-1beta, VEGF-A cytokines in meibomian gland epithelial cells.Conclusion: LPS + LBP is shown to induce the secretion of certain proinflammatory cytokines from ocular surface and adnexal epithelial cells. Dihydrotestosterone 88-91 interleukin 6 Homo sapiens 200-204 31738650-5 2021 When these LPS + LBP-stimulated cells were exposed to DHT for 2 days, it was found that DHT suppressed the secretion of IL-6, IL-10, IL-1beta, VEGF-A cytokines in corneal epithelial cells; TNF-alpha, IL-6, IL-1beta, VEGF-A cytokines in conjunctival epithelial cells; and IL-6, IL-1beta, VEGF-A cytokines in meibomian gland epithelial cells.Conclusion: LPS + LBP is shown to induce the secretion of certain proinflammatory cytokines from ocular surface and adnexal epithelial cells. Dihydrotestosterone 88-91 interleukin 6 Homo sapiens 200-204 15817469-5 2005 Thiadiazolidinones inhibited inflammatory activation of cultured brain astrocytes and microglia by diminishing lipopolysaccharide-induced interleukin 6, tumor necrosis factor alpha, inducible nitric-oxide synthase, and inducible cyclooxygenase type 2 expression. thiadiazolidinones 0-18 interleukin 6 Homo sapiens 138-180 31684930-0 2019 1,25-dihydroxyvitamin D3 suppresses lipopolysaccharide-induced interleukin-6 production through aryl hydrocarbon receptor/nuclear factor-kappaB signaling in oral epithelial cells. Calcitriol 0-24 interleukin 6 Homo sapiens 63-76 15876336-7 2005 RESULTS: IL-6 levels were increased in the acute phase of stroke compared with healthy controls (P = 0.002) and correlated with larger stroke volume (P = 0.012) and less favorable prognosis after 1 year, measured by ESS (P = 0.014) and BI (P = 0.006). Bismuth 236-238 interleukin 6 Homo sapiens 9-13 31684930-6 2019 RESULTS: 1,25D3 inhibited LPS-induced IL-6 overexpression in OKF6/TERT-2 cells. Calcitriol 9-15 interleukin 6 Homo sapiens 38-42 31684930-8 2019 Furthermore, 1,25D3 suppressed IL-6 expression and enhanced VDR expression and regulated AhR/NF-kappaB signaling activation in a dose-dependent manner after 48 h treatment. Calcitriol 13-19 interleukin 6 Homo sapiens 31-35 15965071-7 2005 ELISA revealed that LPS increased macrophage TNF-alpha, IL-1beta, and IL-6 protein levels in a time-dependent manner, whereas propofol significantly reduced the levels of LPS-enhanced TNF-alpha, IL-1beta, and IL-6 proteins. Propofol 126-134 interleukin 6 Homo sapiens 209-213 31684930-9 2019 CONCLUSIONS: These results suggest that 1,25D3 may inhibit LPS-induced IL-6 overexpression in human oral epithelial cells through AhR/NF-kappaB signaling. Calcitriol 40-46 interleukin 6 Homo sapiens 71-75 15965071-11 2005 The present study shows that propofol, at a therapeutic concentration, has anti-inflammatory and antioxidative effects on the biosyntheses of TNF-alpha, IL-1beta, IL-6, and NO in LPS-activated macro-phages and that the suppressive effects are exerted at the pretranslational level. Propofol 29-37 interleukin 6 Homo sapiens 163-167 31542660-0 2019 The organochlorine pesticides pentachlorophenol and dichlorodiphenyltrichloroethane increase secretion and production of interleukin 6 by human immune cells. DDT 52-83 interleukin 6 Homo sapiens 121-134 31542660-4 2019 Immune cells exposed to PCP at 0.05-5 muM and DDT at 0.025-2.5 muM showed increased secretion of IL-6 when the cell preparations contained either T lymphocytes or monocytes. DDT 46-49 interleukin 6 Homo sapiens 97-101 15843537-4 2005 The results presented in this study demonstrate that the saturated fatty acid, lauric acid, up-regulates the expression of costimulatory molecules (CD40, CD80, and CD86), MHC class II, and cytokines (IL-12p70 and IL-6) in bone marrow-derived DCs. lauric acid 79-90 interleukin 6 Homo sapiens 213-217 31542660-5 2019 Increased IL-6 secretion was due to PCP and DDT induced cellular production of the cytokine and was dependent on MAP kinase signaling pathways (in the case of PCP). DDT 44-47 interleukin 6 Homo sapiens 10-14 31542660-7 2019 Thus, both PCP and DDT have the potential to produce chronic inflammation by stimulating production of IL-6 by immune cells. DDT 19-22 interleukin 6 Homo sapiens 103-107 31012803-7 2019 Also, significant changes were observed in interleukin (IL)-6 levels in magnesium and choline-magnesium groups (p < 0.05). Choline 86-93 interleukin 6 Homo sapiens 43-61 15564333-7 2005 Treatment of adipose tissue and skeletal muscle with sulfasalazine and BAY 11-7082 significantly inhibited the release of IL-6, IL-8, and TNF-alpha; NF-kappa B p65 DNA-binding activity; and IKK-beta protein expression (P < 0.05, by Newman-Keuls test). Sulfasalazine 53-66 interleukin 6 Homo sapiens 122-126 31012803-9 2019 When adjusted for potential confounders, inflammation and endothelial factors (IL-6 and VCAM-1) decreased significantly in the choline-magnesium group as compared to other groups (p < 0.05). Choline 127-134 interleukin 6 Homo sapiens 79-83 15796767-9 2005 The LPS-induced IL-6 production was blocked by the specific p38alphaMAP kinase inhibitor, SB203580, and by the synthetic glucocorticoid, dexamethasone. SB 203580 90-98 interleukin 6 Homo sapiens 16-20 31618900-7 2019 In addition to the activation of apoptotic pathways, TRAIL-mediated inflammatory responses were attenuated by GlcN pretreatment reducing nuclear NF-kB levels and the expression of downstream target genes IL-6 and IL-8. Glucosamine 110-114 interleukin 6 Homo sapiens 204-208 15661041-5 2005 A decrease in the response of CM to LPS was observed morphologically and functionally, with CM grown in the presence of imatinib showing decreased pseudopodia formation and inhibition of IL-6 and TNF-alpha production following LPS stimulation. Imatinib Mesylate 120-128 interleukin 6 Homo sapiens 187-191 32133074-3 2019 The purpose of this study was to investigate the effects of carvacrol on IL-6 gene expression, pSTAT3, pAKT, pERK1/2 cellular signaling proteins, and invasion in human prostate cancer PC3 cells. carvacrol 60-69 interleukin 6 Homo sapiens 73-77 15673326-7 2005 Proinflammatory cytokines, and particularly IL-6, showed a positive correlation with the levels of circulating pentosidine. pentosidine 111-122 interleukin 6 Homo sapiens 44-48 32133074-8 2019 Carvacrol led to a significant reduction (P < 0.05) for IL-6 gene expression in a dose-dependent manner compared to control. carvacrol 0-9 interleukin 6 Homo sapiens 56-60 15582581-5 2005 Over the same concentration range of the nucleotide that was effective for IL-6 synthesis, ATP caused an increase in the intracellular Ca(2+) concentration ([Ca(2+)](i)), which increase was inhibited by pretreatment with suramin, a P2Y receptor antagonist, or 2-aminoethoxydiphenyl borate (2-APB), an inositol 1,4,5-trisphosphate receptor blocker, but not by the extracellular Ca(2+)-chelating agent EGTA. 2-aminoethoxydiphenyl borate 290-295 interleukin 6 Homo sapiens 75-79 15582581-6 2005 The pretreatment of SaM-1 cells with suramin or 2-APB also inhibited the increase in IL-6 synthesis in response to ATP. 2-aminoethoxydiphenyl borate 48-53 interleukin 6 Homo sapiens 85-89 32133074-9 2019 IL-6 protein reduced 41.5% and 52.7% when compared with control cells at 360 and 420 muM of carvacrol, respectively. carvacrol 92-101 interleukin 6 Homo sapiens 0-4 15345332-6 2004 Furthermore, both SB203580 (an inhibitor of p38 mitogen-activated protein kinase [MAPK]) and PD98059 (an inhibitor of MEK, upstream of ERK) attenuated the BK-induced IL-6 and PGE(2) synthesis. SB 203580 18-26 interleukin 6 Homo sapiens 166-170 32133074-12 2019 Conclusions: Decreased IL-6 protein level by carvacrol resulted in diminishing of pSTAT3, pERK1/2, and pAKT signaling proteins, which leads to the reduction of the cell survival, proliferation, and invasion in PC3 cells. carvacrol 45-54 interleukin 6 Homo sapiens 23-27 31594856-5 2019 However, high amounts of PGE2 and the proinflammatory cytokines IL-1beta and IL-6 were secreted by monocytes activated with MDP in the presence of conditioned medium obtained from CD3 bead-isolated T cells (Tc CM) but not from those isolated without CD3 beads. Acetylmuramyl-Alanyl-Isoglutamine 124-127 interleukin 6 Homo sapiens 77-81 15474071-0 2004 Synergistic effect of interleukin (IL)-1alpha and ceramide analogue on the production of IL-6, IL-8, and macrophage colony-stimulating factor by endometrial stromal cells. Ceramides 50-58 interleukin 6 Homo sapiens 89-93 31594856-7 2019 Antibody-mediated blockade of GPIbalpha or of its receptor, Mac-1 integrin, inhibited the secretion of PGE2, IL-1beta, and IL-6 in MDP + Tc CM-activated monocytes, whereas recombinant GPIbalpha protein increased PGE2 production by MDP-treated monocytes. Acetylmuramyl-Alanyl-Isoglutamine 131-134 interleukin 6 Homo sapiens 123-127 31208913-10 2019 Finally, in a xenograft model, overexpressing miR-338-5p in CRC cells and HIF-1alpha inhibitor PX-478 were able to enhance the sensitivity of CRC to oxaliplatin (OXA) via suppressing the HIF-1alpha/miR-338-5p/IL-6 feedback loop in vivo. Oxaliplatin 162-165 interleukin 6 Homo sapiens 209-213 15578470-11 2004 Interleukin-6 concentrations were greater in the control group than the propofol group 4 hours after clamp release (289.1 [165.2-561] rhog/mL v 153.2 (58.2-280.3) rhog/mL, respectively, p = 0.003). Propofol 72-80 interleukin 6 Homo sapiens 0-13 15251176-9 2004 When cells exposed to 200 microM SM were treated with the p38 MAP kinase inhibitor SB203580, the levels of IL-8, IL-6, and TNF-alpha and IL-1beta were significantly decreased when compared with cells that were untreated. SB 203580 83-91 interleukin 6 Homo sapiens 113-117 31271872-5 2019 Moreover, Tnc induces histone-deacetylase 1 (HDAC1) expression in microglia, such that HDAC1 inhibition by MS-275 decreases Tnc-induced microglial IL-6 and TNF-alpha production. entinostat 107-113 interleukin 6 Homo sapiens 147-151 15117678-6 2004 Expression of IL-1beta, IL-6, IL-8, and COX-2 mRNA was reduced by 30 microM PP1, an Src family tyrosine kinase inhibitor, and by 25 microM SB-203580, a p38 MAPK inhibitor. SB 203580 139-148 interleukin 6 Homo sapiens 24-28 15381112-1 2004 While screening for novel IL-6 inhibitors, we synthesized 20S,21-epoxy-resibufogenin-3-acetate (ERBA). 20,21-epoxyresibufogenin-3-acetate 58-94 interleukin 6 Homo sapiens 26-30 15381112-1 2004 While screening for novel IL-6 inhibitors, we synthesized 20S,21-epoxy-resibufogenin-3-acetate (ERBA). 20,21-epoxyresibufogenin-3-acetate 96-100 interleukin 6 Homo sapiens 26-30 31531960-0 2019 Circulating interleukin-6 as a biomarker in a randomized controlled trial of modified-release prednisone vs immediate-release prednisolone, in newly diagnosed patients with giant cell arteritis. Prednisone 94-104 interleukin 6 Homo sapiens 12-25 15383152-7 2004 However, IL-6, IL-8, and IL-13 production induced by IL-1 beta were significantly enhanced by addition of epinephrine. Epinephrine 106-117 interleukin 6 Homo sapiens 9-13 15373762-1 2004 PROBLEM: The cytokine, interleukin-6 (IL-6), stimulates the production of human chorionic gonadotropine (hCG) in chorionic cells. chorionic gonadotropine 80-103 interleukin 6 Homo sapiens 23-36 31531960-8 2019 CONCLUSION: Our study suggests that elevated levels of IL-6 in new GCA are better suppressed by MR prednisone compared with IR prednisolone. Prednisone 99-109 interleukin 6 Homo sapiens 55-59 15373762-1 2004 PROBLEM: The cytokine, interleukin-6 (IL-6), stimulates the production of human chorionic gonadotropine (hCG) in chorionic cells. chorionic gonadotropine 80-103 interleukin 6 Homo sapiens 38-42 15373762-1 2004 PROBLEM: The cytokine, interleukin-6 (IL-6), stimulates the production of human chorionic gonadotropine (hCG) in chorionic cells. DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-GLYCINE 105-108 interleukin 6 Homo sapiens 23-36 15373762-1 2004 PROBLEM: The cytokine, interleukin-6 (IL-6), stimulates the production of human chorionic gonadotropine (hCG) in chorionic cells. DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-GLYCINE 105-108 interleukin 6 Homo sapiens 38-42 15320881-7 2004 Increases of IL-6 protein were 3000-fold for LPS, threefold for 16-phe-LXA4, eightfold for LXA(4 and) twofold for LTB4. 16-phe-lxa4 64-75 interleukin 6 Homo sapiens 13-17 15320881-7 2004 Increases of IL-6 protein were 3000-fold for LPS, threefold for 16-phe-LXA4, eightfold for LXA(4 and) twofold for LTB4. N-(1H-benzimidazol-2-ylmethyl)-2-methoxyacetamide 71-74 interleukin 6 Homo sapiens 13-17 31250540-10 2019 Supplementation with 2,000-IU/d vitamin D3 is more effective than 1,000 IU/d in pregnant women in terms of increasing circulating 25(OH)D, ameliorating pro-inflammatory markers notably TNF-alpha in mother and IL-6 in cord blood, and improving neonatal outcomes including the birth sizes. Cholecalciferol 32-42 interleukin 6 Homo sapiens 209-213 15320881-8 2004 Prior exposure of MO to 16-phe-LXA4, but not LXA4, reduced LTB4 induced synthesis of IL-1beta with 66%, IL-6 with 20% and IL-1Ra with 29%. 16-phe-lxa4 24-35 interleukin 6 Homo sapiens 104-108 14996842-9 2004 The mRNA for ligands of the gp130-JAK/STAT3 signaling pathway, interleukin-6, leukemia inhibitory factor, and oncostatin M were elevated prior to activation of STAT3 and induction of astrogliosis; neuroprotection with nomifensine blocked these effects of MPTP. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 255-259 interleukin 6 Homo sapiens 63-76 14998552-7 2004 SB203580 and PD98059 decreased LPS-induced gene expression of IL-1beta and IL-6. SB 203580 0-8 interleukin 6 Homo sapiens 75-79 15041589-0 2004 Xenon and isoflurane differentially modulate lipopolysaccharide-induced activation of the nuclear transcription factor KB and production of tumor necrosis factor-alpha and interleukin-6 in monocytes. Xenon 0-5 interleukin 6 Homo sapiens 172-185 15303261-0 2004 In vitro effects of the dicyclohexylammonium salt of hyperforin on interleukin-6 release in different experimental models. Dicyclohexylammonium Salt 24-49 interleukin 6 Homo sapiens 67-80 15303261-0 2004 In vitro effects of the dicyclohexylammonium salt of hyperforin on interleukin-6 release in different experimental models. hyperforin 53-63 interleukin 6 Homo sapiens 67-80 15303261-3 2004 [3H]SP binding experiments in parallel on the same intact cells indicate that hyperforin-DCHA does not interact with neuro-kinin-I receptors but very likely interacts with some intracellular steps leading to the synthesis and/or release of IL6. hyperforin 78-88 interleukin 6 Homo sapiens 240-243 15303261-4 2004 Hyperforin-DCHA also inhibited, with a similar IC50, the IL6 release induced in U373MG cells by two other classic proinflammatory stimuli,ILl and lipopolysaccharide (LPS), as well as the LPS-induced IL6 release in whole rat blood. hyperforin 0-10 interleukin 6 Homo sapiens 57-60 15303261-4 2004 Hyperforin-DCHA also inhibited, with a similar IC50, the IL6 release induced in U373MG cells by two other classic proinflammatory stimuli,ILl and lipopolysaccharide (LPS), as well as the LPS-induced IL6 release in whole rat blood. hyperforin 0-10 interleukin 6 Homo sapiens 199-202 15041589-7 2004 LPS-induced production of TNF-alpha and IL-6 as well as activation of NF-kappaB were significantly increased in the presence of xenon compared with controls. Xenon 128-133 interleukin 6 Homo sapiens 40-44 15041589-9 2004 Our results demonstrate that xenon and isoflurane have opposite effects on the LPS-induced production of TNF-alpha and IL-6. Xenon 29-34 interleukin 6 Homo sapiens 119-123 31251107-10 2019 The results disclosed that HG inhibited cell viability, promoted apoptosis, up-regulated IL-6 and TNF-alpha, as well as increased ROS level in ARPE-19 cells. Mercury 27-29 interleukin 6 Homo sapiens 89-93 15084515-9 2004 In addition, lycopene down-regulated prostatic IGF-I and IL-6 expression. Lycopene 13-21 interleukin 6 Homo sapiens 57-61 31269454-6 2019 It was found that the incubation of macrophages with CaPs substrates caused a decrease of pro-inflammatory cytokines, more pronounced for beta-TCP compared with CDHA showing significantly decreased IL-6, TNF-a, and iNOS. cdha 161-165 interleukin 6 Homo sapiens 198-202 15112251-6 2004 An increase in 3-MH excretion under surgical stress was positively correlated with postoperative consumption of IL-6 soluble receptor (sR) in elderly patients with nutritional depletion. 3-methylhistidine 15-19 interleukin 6 Homo sapiens 112-116 15077871-6 2004 After reverting to the cellulose acetate membrane for 1 month, plasma levels of protein thiols and IL-6 returned to baseline while levels of other variables were not significantly different from values at the end of the polysulphone dialysis period. acetylcellulose 23-40 interleukin 6 Homo sapiens 99-103 14975053-9 2004 At 6 hours the IL-6 concentration was significantly lower in the ceftazidime group than in the saline group (P < 0.05), and in both the ceftazidime and the tobramycin groups there were significantly greater reductions from peak values (P < 0.05). Ceftazidime 65-76 interleukin 6 Homo sapiens 15-19 14975053-11 2004 However, our data indicate a possible anti-inflammatory effect exerted by both ceftazidime and tobramycin, which manifested as a significantly greater reduction in IL-6 in comparison with the untreated group. Ceftazidime 79-90 interleukin 6 Homo sapiens 164-168 31491838-4 2019 Using an ELISA-based assay, we demonstrate that MH binds directly to IL-6Ralpha, significantly inhibiting (~60%) its binding to the IL-6 ligand. mh 48-50 interleukin 6 Homo sapiens 69-73 14975053-11 2004 However, our data indicate a possible anti-inflammatory effect exerted by both ceftazidime and tobramycin, which manifested as a significantly greater reduction in IL-6 in comparison with the untreated group. Tobramycin 95-105 interleukin 6 Homo sapiens 164-168 15047718-5 2004 We found that carlreticulin is in fact located on the surface of monocytes and that the IL-6 production stimulated by an azurucidin is inhibited by anti-calreticulin antibody. azurucidin 121-131 interleukin 6 Homo sapiens 88-92 14565941-9 2004 Activation of p38 MAPK was also seen in cocultures by Western blot, whereas IL-6 production in cocultures was significantly inhibited by the p38 inhibitor SB203580. SB 203580 155-163 interleukin 6 Homo sapiens 76-80 31220448-10 2019 Verteporfin treatment activated the protein kinase B/mechanistic target of rapamycin signaling pathway and dramatically impaired IL-6-stimulated STAT3 phosphorylation in ICC cells. Verteporfin 0-11 interleukin 6 Homo sapiens 129-133 15128054-10 2004 In 82 RAU patients with the serum IL-6 or IL-8 levels higher than the upper limit of normal serum concentration, treatment with levamisole for a period of 0.5-3.5 months could significantly reduce the serum IL-6 level from 12.0 +/- 1.6 to 3.0 +/- 0.5 pg/ml (P < 0.001), and could significantly lower the serum IL-8 level from 70.9 +/- 11.2 to 13.8 +/- 3.1 pg/ml (P < 0.001). Levamisole 128-138 interleukin 6 Homo sapiens 34-38 15128054-10 2004 In 82 RAU patients with the serum IL-6 or IL-8 levels higher than the upper limit of normal serum concentration, treatment with levamisole for a period of 0.5-3.5 months could significantly reduce the serum IL-6 level from 12.0 +/- 1.6 to 3.0 +/- 0.5 pg/ml (P < 0.001), and could significantly lower the serum IL-8 level from 70.9 +/- 11.2 to 13.8 +/- 3.1 pg/ml (P < 0.001). Levamisole 128-138 interleukin 6 Homo sapiens 207-211 14675092-7 2003 At 4 mmol L-1 nicotinamide, inhibition of TF expression and IL-6 and a normalization of COT were seen. Niacinamide 14-26 interleukin 6 Homo sapiens 60-64 12853969-6 2003 IL-6 activation by TGF-beta1 was accompanied by nuclear translocation of NF-kappaB, which was blocked by the p38 inhibitors SB202190 and SB203580 or by IkappaBalphaDeltaN transfection, indicating the crucial role for the p38-NF-kappaB signaling in TGF-beta1 induction of IL-6. SB 203580 137-145 interleukin 6 Homo sapiens 0-4 15128054-12 2004 Levamisole can modulate both the serum IL-6 and IL-8 levels in RAU patients. Levamisole 0-10 interleukin 6 Homo sapiens 39-43 31162892-6 2019 RESULTS: Flo Sinus Care with kappa-carrageenan rinse solutions resulted in a marked reduction of interleukin-6 (IL-6) production by HNECs from CRS patients (p = 0.007). Carrageenan 29-46 interleukin 6 Homo sapiens 97-110 14996410-4 2004 imipramine and venlafaxine (at the higher concentration), 5-HTP (at lower and higher concentrations) and a combination of 5-HTP and fluoxetine (both at the lower concentration) increased the production of IL-6; (2). 5-Hydroxytryptophan 58-63 interleukin 6 Homo sapiens 205-209 14996410-4 2004 imipramine and venlafaxine (at the higher concentration), 5-HTP (at lower and higher concentrations) and a combination of 5-HTP and fluoxetine (both at the lower concentration) increased the production of IL-6; (2). 5-Hydroxytryptophan 122-127 interleukin 6 Homo sapiens 205-209 12790840-13 2003 Low IL-6 levels in chronic anovulation may be a marker of resistance to clomiphene citrate. Clomiphene 72-90 interleukin 6 Homo sapiens 4-8 12901849-0 2003 SP500263, a novel SERM, blocks osteoclastogenesis in a human bone cell model: role of IL-6 and GM-CSF. SP500263 0-8 interleukin 6 Homo sapiens 86-90 31162892-6 2019 RESULTS: Flo Sinus Care with kappa-carrageenan rinse solutions resulted in a marked reduction of interleukin-6 (IL-6) production by HNECs from CRS patients (p = 0.007). Carrageenan 29-46 interleukin 6 Homo sapiens 112-116 14964578-8 2004 The levels of CSF IL-6 and IFN-gamma in patients with non-herpetic ALE were significantly lower than those in patients with HSE (p<0.05 and p<0.01, respectively). Epinephrine 67-70 interleukin 6 Homo sapiens 18-22 12792728-10 2003 Our results suggested that tumor cells could be an important source of elevated serum IL-6 in patients with NPC and that IL-6 level in NPC patients was proportional to the serum butyrate concentration. Butyrates 178-186 interleukin 6 Homo sapiens 121-125 14964578-12 2004 The levels of IL-6 and IFN-gamma in the CSF of patients with non-herpetic ALE were significantly lower than those of patients with HSE, possibly reflecting an immunological process in this type of ALE rather than direct viral infection. Epinephrine 74-77 interleukin 6 Homo sapiens 14-18 31162892-9 2019 CONCLUSIONS: The commonly used sinus irrigation product Flo Sinus Care with added kappa-carrageenan reduces IL-6 production by HNECs in vitro. Carrageenan 82-99 interleukin 6 Homo sapiens 108-112 14964578-12 2004 The levels of IL-6 and IFN-gamma in the CSF of patients with non-herpetic ALE were significantly lower than those of patients with HSE, possibly reflecting an immunological process in this type of ALE rather than direct viral infection. Epinephrine 197-200 interleukin 6 Homo sapiens 14-18 12792728-11 2003 In vitro, IL-6 expression in NPC cells could be up-regulated by butyrate. Butyrates 64-72 interleukin 6 Homo sapiens 10-14 30043661-7 2019 Studying the impact of monomethyl fumarate (MMF), the primary metabolite of DMF, on B cell effector function in vitro showed that MMF increased the frequency of transforming growth factor (TGF)-beta-producing B cells and decreased the frequency of B cells secreting lymphotoxin (LT)-alpha, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and to a lesser extent IL-10. citraconic acid 23-42 interleukin 6 Homo sapiens 325-343 12794817-6 2003 RESULTS: Upon treatment with anti-TNF, we observed a fast decrease in the levels of serum IL-6, particularly in RA patients who did not receive parallel prednisolone treatment (P = 0.043). Prednisolone 153-165 interleukin 6 Homo sapiens 90-94 14688371-4 2004 In contrast, mast cells of the MC(TC) phenotype from skin and lung were resistant to IL-4-mediated apoptosis, even after neutralization of endogenous IL-6. Methylcholanthrene 31-33 interleukin 6 Homo sapiens 150-154 30043661-7 2019 Studying the impact of monomethyl fumarate (MMF), the primary metabolite of DMF, on B cell effector function in vitro showed that MMF increased the frequency of transforming growth factor (TGF)-beta-producing B cells and decreased the frequency of B cells secreting lymphotoxin (LT)-alpha, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and to a lesser extent IL-10. citraconic acid 44-47 interleukin 6 Homo sapiens 325-343 12801316-11 2003 CONCLUSION: Pranlukast and MK-571 partially inhibited NF-kappa B activation in 1.3% DMSO-differentiated U-937 and Jurkat cells, and IL-6 release in PBMC. pranlukast 12-22 interleukin 6 Homo sapiens 132-136 31349736-3 2019 Pretreatments with Rif and RifQ reduced the secretion of prototypical inflammatory cytokines (TNF- , IL-6) and the burst of oxidative stress in microglial cells activated with alphaS fibrillary aggregates. Rifampin 19-22 interleukin 6 Homo sapiens 101-105 12531799-9 2003 Importantly, SAHA sensitized MM.1S cells to death receptor-mediated apoptosis and inhibited the secretion of interleukin 6 (IL-6) induced in bone marrow stromal cells (BMSCs) by binding of MM cells, suggesting that it can overcome cell adhesion-mediated drug resistance. Vorinostat 13-17 interleukin 6 Homo sapiens 109-122 12531799-9 2003 Importantly, SAHA sensitized MM.1S cells to death receptor-mediated apoptosis and inhibited the secretion of interleukin 6 (IL-6) induced in bone marrow stromal cells (BMSCs) by binding of MM cells, suggesting that it can overcome cell adhesion-mediated drug resistance. Vorinostat 13-17 interleukin 6 Homo sapiens 124-128 14625484-0 2003 Continuous therapeutic epinephrine but not norepinephrine prolongs splanchnic IL-6 production in porcine endotoxic shock. Epinephrine 23-34 interleukin 6 Homo sapiens 78-82 12792728-0 2003 The elevated serum interleukin-6 correlates with the increased serum butyrate level in patients with nasopharyngeal carcinoma. Butyrates 69-77 interleukin 6 Homo sapiens 19-32 12792728-7 2003 Patients with elevated serum butyrate concentrations (4.2+/-2.2 micro M) also had significantly higher IL-6 levels (29.14+/-5.17 pg/ml). Butyrates 29-37 interleukin 6 Homo sapiens 103-107 12792728-9 2003 In order to investigate the direct relationship between butyrate and IL-6, n-sodium butyrate (n-BT) was added to the NPC cells in an in vitro study, and marked increase of IL-6 expression was detected in n-BT-treated cells. Butyrates 56-64 interleukin 6 Homo sapiens 172-176 31337804-7 2019 Citrate dialysis increased HD efficacy and reduced plasma levels of CRP, fibrinogen, IL6 and chemerin. Citric Acid 0-7 interleukin 6 Homo sapiens 85-88 12762340-4 2003 The possibility that exhaled IL-6 levels are related to exhaled carbon monoxide (CO) and lung function has also been explored. Carbon Monoxide 64-79 interleukin 6 Homo sapiens 29-33 12762340-4 2003 The possibility that exhaled IL-6 levels are related to exhaled carbon monoxide (CO) and lung function has also been explored. Carbon Monoxide 81-83 interleukin 6 Homo sapiens 29-33 12761263-9 2003 Also, the plasma pentosidine content showed weak but significant positive correlations with CRP (Rho = 0.28; P < 0.0001), fibrinogen (Rho = 0.23; P < 0.01; n = 126), IL-6 (Rho = 0.22; P < 0.01; n = 169), and soluble vascular cellular adhesion molecule-1 (Rho = 0.38; P < 0.001; n = 74). pentosidine 17-28 interleukin 6 Homo sapiens 172-176 31241125-4 2019 (2) Dietary putrescine increased the lysozyme and acid phosphatase activities and the amount of immunoglobulin M, antibacterial peptides, and transforming growth factor beta1, but decreased the mRNA levels of tumor necrosis factor alpha, interleukin-6, interleukin-8 and inducible nitric oxide synthase (P < 0.05). Putrescine 12-22 interleukin 6 Homo sapiens 238-251 12505790-3 2003 Treatment with the p38 inhibitor SB-203580, the MEK1 and MEK2 inhibitor U-0126, or the translational inhibitor cycloheximide inhibited the induction of C/EBP beta and IL-6 by IFN-gamma, whereas the MEK1 inhibitor PD-98059 or the tyrosine kinase inhibitor genistein had no effect. SB 203580 33-42 interleukin 6 Homo sapiens 167-171 12653859-0 2003 Levamisole and Chinese medicinal herbs can modulate the serum interleukin-6 level in patients with recurrent aphthous ulcerations. Levamisole 0-10 interleukin 6 Homo sapiens 62-75 12653859-11 2003 The mean reduction of serum IL-6 level (10.0 +/- 7.1 pg/ml) in RAU patients after treatment with levamisole plus Chinese medicinal herbs was significantly higher than that (5.1 +/- 3.7 pg/ml) in RAU patients after treatment with levamisole only (P < 0.005), suggesting that the combination therapy is superior to the single therapy of levamisole only. Levamisole 97-107 interleukin 6 Homo sapiens 28-32 31396302-9 2019 IL-6 was an independent predictor of L-arginine/ADMA, VEGF-A of ADMA, G-CSF of L-arginine/SDMA, and GM-CSF of L-citrulline and SDMA. Citrulline 110-122 interleukin 6 Homo sapiens 0-4 12653859-11 2003 The mean reduction of serum IL-6 level (10.0 +/- 7.1 pg/ml) in RAU patients after treatment with levamisole plus Chinese medicinal herbs was significantly higher than that (5.1 +/- 3.7 pg/ml) in RAU patients after treatment with levamisole only (P < 0.005), suggesting that the combination therapy is superior to the single therapy of levamisole only. Levamisole 229-239 interleukin 6 Homo sapiens 28-32 12653859-11 2003 The mean reduction of serum IL-6 level (10.0 +/- 7.1 pg/ml) in RAU patients after treatment with levamisole plus Chinese medicinal herbs was significantly higher than that (5.1 +/- 3.7 pg/ml) in RAU patients after treatment with levamisole only (P < 0.005), suggesting that the combination therapy is superior to the single therapy of levamisole only. Levamisole 229-239 interleukin 6 Homo sapiens 28-32 12653859-12 2003 CONCLUSION: We conclude that levamisole and levamisole plus Chinese medicinal herbs can modulate the serum IL-6 level in RAU patients. Levamisole 29-39 interleukin 6 Homo sapiens 107-111 12653859-12 2003 CONCLUSION: We conclude that levamisole and levamisole plus Chinese medicinal herbs can modulate the serum IL-6 level in RAU patients. Levamisole 44-54 interleukin 6 Homo sapiens 107-111 12716789-6 2003 Saturated-to-omega-3 and saturated-to-omega-6 FA ratios were significantly and positively associated with C-reactive protein (P < 0.0001) and IL-6 (P < 0.001), respectively. saturated 0-9 interleukin 6 Homo sapiens 145-149 12716789-6 2003 Saturated-to-omega-3 and saturated-to-omega-6 FA ratios were significantly and positively associated with C-reactive protein (P < 0.0001) and IL-6 (P < 0.001), respectively. saturated 25-34 interleukin 6 Homo sapiens 145-149 12634650-5 2003 Human umbilical vein endothelial cell interleukin-6 production was increased 25% by preeclamptic plasma compared with normal pregnant plasma (P <.005), and increased interleukin-6 production by preeclamptic plasma was inhibited by vitamin E. Vitamin E 234-243 interleukin 6 Homo sapiens 38-51 30924310-7 2019 FINDINGS: Supplementation of HAM-RS2 led to a decrease in serum urea, IL-6, TNFalpha, and malondialdehyde (P < 0.05). ham-rs2 29-36 interleukin 6 Homo sapiens 70-74 12634650-5 2003 Human umbilical vein endothelial cell interleukin-6 production was increased 25% by preeclamptic plasma compared with normal pregnant plasma (P <.005), and increased interleukin-6 production by preeclamptic plasma was inhibited by vitamin E. Vitamin E 234-243 interleukin 6 Homo sapiens 169-182 12634650-6 2003 CONCLUSION: Endothelial cell activation by preeclamptic plasma stimulates interleukin-6 production, which is inhibited by vitamin E. Vitamin E 122-131 interleukin 6 Homo sapiens 74-87 12594059-8 2003 Blocking ERK1/2 with PD98059 or p38 MAPK with SB203580 reduced BK-induced IL-6 expression. SB 203580 46-54 interleukin 6 Homo sapiens 74-78 12563540-0 2003 Sphingosylphosphorylcholine stimulates cellular fibronectin expression through upregulation of IL-6 in cultured human dermal fibroblasts. sphingosine phosphorylcholine 0-27 interleukin 6 Homo sapiens 95-99 31115521-0 2019 Triptolide exerts an anti-tumor effect on non-small cell lung cancer cells by inhibiting activation of the IL-6/STAT3 axis. triptolide 0-10 interleukin 6 Homo sapiens 107-111 12631257-6 2003 RESULTS: In both groups, the combination of chemotherapy with either pamidronate or ibandronate produced a reduction in bone resorption and tumour burden as measured by NTX, IL-6, paraprotein, CRP, and beta 2-microglobulin from the second month of treatment, having no effect on bone formation. Ibandronic Acid 84-95 interleukin 6 Homo sapiens 174-178 12586608-4 2003 CS and CT strongly inhibited the production of proinflammatory cytokines (IL-1alpha, IL-1beta, IL-6, IL-8, and TNF-alpha) from LPS-stimulated human monocytes. ct 7-9 interleukin 6 Homo sapiens 95-99 31115521-8 2019 Additionally, IL-6-induced activation of STAT3 target genes (e.g. MCL-1 and BCL-2) was attenuated by TP and homoharringtonine. triptolide 101-103 interleukin 6 Homo sapiens 14-18 12502991-10 2003 In patients of the PA + PCEA group in the postoperative period, production of IL-1beta, IL-6, IL-1ra, and IL-10 was significantly less elevated, while IL-2 production was significantly less suppressed. pcea 24-28 interleukin 6 Homo sapiens 88-92 12115453-8 2002 CS reduced the release of VEGF, IL-6, and MMP-2, although it had no significant effect on the release of NO and MMP-9. Chondroitin Sulfates 0-2 interleukin 6 Homo sapiens 32-36 31013450-4 2019 Lovastatin treatment resulted in increased levels of IL-6, IL-12p40, and IFN-gamma mRNA in both PBMCs and monocytes following LPS stimulation compared with control cells. Lovastatin 0-10 interleukin 6 Homo sapiens 53-57 12137744-5 2002 The inhibitors SB203580, PD98059, SN50, cycloheximide and D-ribofuranosylbenzimidazole each reduced the basal and TNFalpha-stimulated secretion of IL-1beta and also reduced IL-6 secretion with the exception of SN50. SB 203580 15-23 interleukin 6 Homo sapiens 173-177 12067409-0 2002 Proteasome inhibitor MG-132 enhances the expression of interleukin-6 in human umbilical vein endothelial cells: Involvement of MAP/ERK kinase. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 21-27 interleukin 6 Homo sapiens 55-68 12067409-4 2002 MG-132 increased the expression of IL-6 mRNA and protein;and this effect was abolished by the pretreatment of the cells with U0126, an inhibitor of MAP or ERK kinases (MEK 1/2). benzyloxycarbonylleucyl-leucyl-leucine aldehyde 0-6 interleukin 6 Homo sapiens 35-39 12067409-7 2002 We conclude that a protease inhibitor MG-132 upregulates IL-6 expression in vascular endothelial cells, at least in part, through the activation of MEK 1/2. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 38-44 interleukin 6 Homo sapiens 57-61 12640327-31 2003 It has been shown that a dietary increase of polyunsaturated omega 3 fatty acids reduced strongly the production of IL-1 beta, IL-2, IL-6 and TNF-alpha (tumor necrosis factor-alpha). polyunsaturated omega 3 fatty acids 45-80 interleukin 6 Homo sapiens 133-137 30729713-1 2019 AIM: Vitamin D3 or 25(OH)D3 may have a potential role in rheumatoid arthritis (RA) pathogenesis by inhibiting the expression of pro-inflammatory cytokines including interleukin-6 (IL-6). Cholecalciferol 5-15 interleukin 6 Homo sapiens 165-178 12361954-5 2002 This interaction, which does not seem to involve a classical phosphotyrosine SH2-mediated binding, however, significantly enhances the interaction of Stat3 and the IL-6 receptor subunit glycoprotein (gp) 130, which is the initial step for Stat3 activation by IL-6. Phosphotyrosine 61-76 interleukin 6 Homo sapiens 164-168 12023021-4 2002 By prednisolone or phorbol myristate acetate treatment, EC-SOD levels were correlated negatively with levels of IL-6 and IL-8. Prednisolone 3-15 interleukin 6 Homo sapiens 112-116 30729713-1 2019 AIM: Vitamin D3 or 25(OH)D3 may have a potential role in rheumatoid arthritis (RA) pathogenesis by inhibiting the expression of pro-inflammatory cytokines including interleukin-6 (IL-6). Cholecalciferol 5-15 interleukin 6 Homo sapiens 180-184 31083174-5 2019 After 7, 14, and 30 days, the changes in pathological lung characteristics in the 2 groups were assessed, and survival rates were calculated.Edaravone significantly increased the serum levels of SOD and obviously markedly reduce the serum levels of IL-6, IL-10, TNF-alpha, and MDA in patients poisoned with paraquat (P < .05). Edaravone 141-150 interleukin 6 Homo sapiens 249-253 12036196-0 2002 An (CA)n dinucleotide repeat polymorphism of the interleukin-6 (IL-6) gene is associated with metacarpal bone mineral density in hemodialysis patients. (ca)n dinucleotide 3-21 interleukin 6 Homo sapiens 49-62 12036196-0 2002 An (CA)n dinucleotide repeat polymorphism of the interleukin-6 (IL-6) gene is associated with metacarpal bone mineral density in hemodialysis patients. (ca)n dinucleotide 3-21 interleukin 6 Homo sapiens 64-68 12471309-10 2002 The increased level of adrenaline contributes to the enormous increase in plasma IL-6 only to a minor degree during strenuous exercise. Epinephrine 23-33 interleukin 6 Homo sapiens 81-85 31110480-8 2019 Results: In the present study, RIPC treatment significantly reduced plasma levels of cardiac troponin T (p < 0.05), heart-type fatty acid binding protein (p < 0.05), ischemia modified albumin (p < 0.05), malondialdehyde (p < 0.05), as well as plasma levels of pro-inflammatory cytokines including IL-6, IL-8, and TNF-alpha (P < 0.05, respectively). ripc 31-35 interleukin 6 Homo sapiens 309-313 12479703-9 2002 The addition of interleukin 6 to MM1.S cells treated with gemcitabine offered no protection against gemcitabine-induced cell death. gemcitabine 58-69 interleukin 6 Homo sapiens 16-29 12215301-2 2002 METHODS: Apoptosis in XG-7 myeloma cells induced by IL-6 withdrawal was determined by flow cytometry with propidium iodide (PI) nuclear staining. Propidium 106-122 interleukin 6 Homo sapiens 52-56 12020969-6 2002 Interestingly, SB203580 reduced the mRNA expression for iNOS, TNFalpha, and IL-6, indicating inhibition prior to translation. SB 203580 15-23 interleukin 6 Homo sapiens 76-80 12076322-0 2002 Serum interleukin-6 level is a useful marker in evaluating therapeutic effects of levamisole and Chinese medicinal herbs on patients with oral lichen planus. Levamisole 82-92 interleukin 6 Homo sapiens 6-19 12076322-11 2002 The mean reduction of serum IL-6 level in OLP patients treated with levamisole plus Chinese medicinal herbs was significantly higher (7.4 +/- 4.7 pg/ml) than that in OLP patients treated with levamisole only (3.8 +/- 2.3 pg/ml, P < 0.05), suggesting that the combination therapy was superior to levamisole only. Levamisole 68-78 interleukin 6 Homo sapiens 28-32 12076322-11 2002 The mean reduction of serum IL-6 level in OLP patients treated with levamisole plus Chinese medicinal herbs was significantly higher (7.4 +/- 4.7 pg/ml) than that in OLP patients treated with levamisole only (3.8 +/- 2.3 pg/ml, P < 0.05), suggesting that the combination therapy was superior to levamisole only. Levamisole 192-202 interleukin 6 Homo sapiens 28-32 12076322-11 2002 The mean reduction of serum IL-6 level in OLP patients treated with levamisole plus Chinese medicinal herbs was significantly higher (7.4 +/- 4.7 pg/ml) than that in OLP patients treated with levamisole only (3.8 +/- 2.3 pg/ml, P < 0.05), suggesting that the combination therapy was superior to levamisole only. Levamisole 192-202 interleukin 6 Homo sapiens 28-32 12076322-12 2002 CONCLUSION: We conclude that levamisole and levamisole plus Chinese medicinal herbs can modulate the serum IL-6 level in OLP patients. Levamisole 29-39 interleukin 6 Homo sapiens 107-111 12143044-6 2002 The cPLA(2) inhibitor arachidonyl fluorophosphonate (MAFP) and the COX-2 inhibitor NS-398 significantly inhibited HGF- and IL-6-induced release of AA, PG synthesis, and proliferation in SG231 cells as well as two other human cholangiocarcinoma cell lines, HuCCT1 and CC-LP-1 cells. MAFP 53-57 interleukin 6 Homo sapiens 123-127 31929726-6 2019 Receptor Activator of NF-kappaB Ligand (RANKL)/ Osteoprotegerine (OPG) ratio is elevated in favor of RANKL in a time-dependent manner, and further RANKL production is caused by upregulation of Interleukin-6 (IL-6) and the inflammation pathway. osteoprotegerine 48-64 interleukin 6 Homo sapiens 193-206 12113544-6 2002 Preoperative administration of gabexate mesilate (preop GM group) substantially ameliorated hepatic I/R injury as compared with the other patients (intraop and without GM groups); postoperative serum transaminase levels were notably decreased in association with marked suppression of IL-6 levels in blood circulation during liver surgery. Gabexate 31-48 interleukin 6 Homo sapiens 285-289 12113544-9 2002 CONCLUSIONS: Preoperative administration of GM is useful for preventing I/R injury of the human liver, accompanied by suppression of the plasma proinflammatory cytokine IL-6. Gabexate 44-46 interleukin 6 Homo sapiens 169-173 12076322-12 2002 CONCLUSION: We conclude that levamisole and levamisole plus Chinese medicinal herbs can modulate the serum IL-6 level in OLP patients. Levamisole 44-54 interleukin 6 Homo sapiens 107-111 11942866-7 2002 RESULTS: Propofol inhibited both IL-6 and IL-10 production at 0.5 microg/mL, 5 microg/mL and 50 microg/mL. Propofol 9-17 interleukin 6 Homo sapiens 33-37 11942866-9 2002 CONCLUSION: Propofol appears to inhibit both IL-6 and IL-10 production by LPS-stimulated PBMCs in vitro. Propofol 12-20 interleukin 6 Homo sapiens 45-49 31929726-6 2019 Receptor Activator of NF-kappaB Ligand (RANKL)/ Osteoprotegerine (OPG) ratio is elevated in favor of RANKL in a time-dependent manner, and further RANKL production is caused by upregulation of Interleukin-6 (IL-6) and the inflammation pathway. osteoprotegerine 48-64 interleukin 6 Homo sapiens 208-212 31929726-6 2019 Receptor Activator of NF-kappaB Ligand (RANKL)/ Osteoprotegerine (OPG) ratio is elevated in favor of RANKL in a time-dependent manner, and further RANKL production is caused by upregulation of Interleukin-6 (IL-6) and the inflammation pathway. SCHEMBL12347590 66-69 interleukin 6 Homo sapiens 193-206 11842936-7 2002 17-phenyl-omega-trinor PGE2, an EP1 agonist, enhanced IL-1beta-induced IL-6 production. 17-phenyltrinorprostaglandin E2 0-27 interleukin 6 Homo sapiens 71-75 12039983-9 2002 In the present experiments, NF-kappaB and AP-1 were involved in the MCP-1-mediated induction of IL-6, as demonstrated by cis element double-stranded (decoy) oligonucleotides (ODN). odn 175-178 interleukin 6 Homo sapiens 96-100 31929726-6 2019 Receptor Activator of NF-kappaB Ligand (RANKL)/ Osteoprotegerine (OPG) ratio is elevated in favor of RANKL in a time-dependent manner, and further RANKL production is caused by upregulation of Interleukin-6 (IL-6) and the inflammation pathway. SCHEMBL12347590 66-69 interleukin 6 Homo sapiens 208-212 30917851-13 2019 Results of the microarray analysis suggest that inflammatory (IL-6) and oxidative stress (NO/ROS) signaling pathways are involved in the pathology linked to PO2 oscillations. PO-2 157-160 interleukin 6 Homo sapiens 62-66 11854436-4 2002 SP500263 also blocked IL-6 production in primary bone cells. SP500263 0-8 interleukin 6 Homo sapiens 22-26 12008923-4 2002 The p38 inhibitor SB 203580 also suppressed their IL-6 production-inducing activities, whereas the ERK1/2-activating MAPK kinase (MEK1) inhibitor PD 98059 did not suppress their activities. SB 203580 18-27 interleukin 6 Homo sapiens 50-54 30835597-6 2019 Moreover, carnitine and chromium co-supplementation upregulated gene expression of interleukin-6 (IL-6) (p = 0.02) and tumor necrosis factor alpha (TNF-alpha) (p = 0.02) compared with the placebo. Carnitine 10-19 interleukin 6 Homo sapiens 83-96 11603453-8 2001 Prednisolone administration reduced postoperative levels of IL-6 (611 versus 92.7 pg/mL; p = 0.003), TNF-alpha (24.4 versus 11.0 pg/L, p = 0.02), and E-selectin (327 versus 107 ng/mL, p = 0.02). Prednisolone 0-12 interleukin 6 Homo sapiens 60-64 11583728-3 2001 Interleukin-6 (IL-6) suppresses the activity of lipoprotein lipase, which modulates the metabolism of triglycerides and HDL-C. To determine whether a reduction of IL-6 contributes to the improvement of lipid profiles, we prospectively investigated the effect of cilostazol (n=16, 100 mg, twice daily) on the changes of lipid profiles and on the association with the changes of IL-6 compared with those of pentoxifylline (n=16, 400 mg, bid) in patients with IC. Cilostazol 262-272 interleukin 6 Homo sapiens 0-13 11846460-7 2002 The production of IL-1beta, IL-6, and IL-8 was also decreased in LPS-activated adherent monocytes by Tau-Cl. N-chlorotaurine 101-107 interleukin 6 Homo sapiens 28-32 30835597-6 2019 Moreover, carnitine and chromium co-supplementation upregulated gene expression of interleukin-6 (IL-6) (p = 0.02) and tumor necrosis factor alpha (TNF-alpha) (p = 0.02) compared with the placebo. Carnitine 10-19 interleukin 6 Homo sapiens 98-102 11583728-3 2001 Interleukin-6 (IL-6) suppresses the activity of lipoprotein lipase, which modulates the metabolism of triglycerides and HDL-C. To determine whether a reduction of IL-6 contributes to the improvement of lipid profiles, we prospectively investigated the effect of cilostazol (n=16, 100 mg, twice daily) on the changes of lipid profiles and on the association with the changes of IL-6 compared with those of pentoxifylline (n=16, 400 mg, bid) in patients with IC. Cilostazol 262-272 interleukin 6 Homo sapiens 15-19 11805217-5 2002 Selective PDE1 inhibition (8-methoxymethyl-3-isobutyl-1-methylxanthine) blockaded lipopolysaccharide-endotoxin (LPS)-mediated biosynthesis of interleukin (IL)-6, but this pathway had no inhibitory effect on tumor necrosis factor-alpha (TNF-alpha). 8-methoxymethyl-3-isobutyl-1-methylxanthine 27-70 interleukin 6 Homo sapiens 142-160 11805217-5 2002 Selective PDE1 inhibition (8-methoxymethyl-3-isobutyl-1-methylxanthine) blockaded lipopolysaccharide-endotoxin (LPS)-mediated biosynthesis of interleukin (IL)-6, but this pathway had no inhibitory effect on tumor necrosis factor-alpha (TNF-alpha). lipopolysaccharide-endotoxin 82-110 interleukin 6 Homo sapiens 142-160 11805217-5 2002 Selective PDE1 inhibition (8-methoxymethyl-3-isobutyl-1-methylxanthine) blockaded lipopolysaccharide-endotoxin (LPS)-mediated biosynthesis of interleukin (IL)-6, but this pathway had no inhibitory effect on tumor necrosis factor-alpha (TNF-alpha). lps 112-115 interleukin 6 Homo sapiens 142-160 11805217-6 2002 Furthermore, inhibition of PDE3 (amrinone) abolished the effect of LPS on IL-6, but attenuated TNF-alpha production. lps 67-70 interleukin 6 Homo sapiens 74-78 11594792-3 2001 Plasma IL-6 concentrations (92.3+/- 31.9 pg/ml) in elderly patients anesthetized with propofol and fentanyl were significantly higher at the end of the operation than that (57.9+/-36.7 pg/ml) of elderly patients anesthetized with sevoflurane and fentanyl. Propofol 86-94 interleukin 6 Homo sapiens 7-11 11594792-5 2001 Plasma IL-6 production after surgical trauma in elderly patients with total intravenous anesthesia with propofol was significantly higher than that in elderly patients with sevoflurane anesthesia. Propofol 104-112 interleukin 6 Homo sapiens 7-11 11805217-10 2002 Finally, nonselective inhibition of PDE by pentoxifylline suppressed LPS-mediated secretion of IL-6 and TNF-alpha. lps 69-72 interleukin 6 Homo sapiens 95-99 30835597-7 2019 CONCLUSION: Overall, the co-administration of carnitine and chromium for 12 weeks to women with PCOS had beneficial effects on mental health parameters, serum total testosterone, mF-G scores, hs-CRP, TAC and MDA levels, and gene expression of IL-6 and TNF-alpha. Carnitine 46-55 interleukin 6 Homo sapiens 243-247 28784051-7 2019 RESULTS: Urolithins decreased media levels of nitric oxide, interleukin 6 (IL-6), prostaglandin E2, and tumor necrosis factor alpha from LPS-BV-2 microglia. urolithins 9-19 interleukin 6 Homo sapiens 60-73 11850221-2 2001 In this study, a 16 amino acid peptide, AROHIB, has been used in an attempt to block the ability of IL-6 plus IL-6sR to stimulate aromatase activity in stromal fibroblasts. arohib 40-46 interleukin 6 Homo sapiens 100-104 11583728-5 2001 IL-6 levels were significantly reduced in patients receiving cilostazol as compared with those receiving placebo or pentoxifylline. Cilostazol 61-71 interleukin 6 Homo sapiens 0-4 11583728-6 2001 The cilostazol-induced changes in the IL-6 were positively related to those of triglycerides in the cilostazol group (r=0.63, P<0.05) and negatively related to those of HDL-C (r=-0.55, P<0.05). Cilostazol 4-14 interleukin 6 Homo sapiens 38-42 11556519-8 2001 RESULTS: We have demonstrated that aceclofenac, 4"-hydroxyaceclofenac and diclofenac significantly decreased interleukin-6 production at concentrations ranged among 1 to 30 microM and fully blocked prostaglandin E2 synthesis by IL-1beta- or LPS-stimulated human chondrocytes. lps 241-244 interleukin 6 Homo sapiens 109-122 11453524-9 2001 Serum levels of tri-iodothyronine in patients with GD positively correlated with serum concentrations of IL-6 (r = 0.35, p<0.025) and sIL-6R (r = 0.31, p<0.047), while no correlation was found between thyroxine and cytokines. Thyroxine 207-216 interleukin 6 Homo sapiens 105-109 11583728-6 2001 The cilostazol-induced changes in the IL-6 were positively related to those of triglycerides in the cilostazol group (r=0.63, P<0.05) and negatively related to those of HDL-C (r=-0.55, P<0.05). Cilostazol 100-110 interleukin 6 Homo sapiens 38-42 28784051-7 2019 RESULTS: Urolithins decreased media levels of nitric oxide, interleukin 6 (IL-6), prostaglandin E2, and tumor necrosis factor alpha from LPS-BV-2 microglia. urolithins 9-19 interleukin 6 Homo sapiens 75-79 30476578-5 2019 The results demonstrated that plantamajoside decreased the production of PGE2, NO, IL-6, and IL-8 in LPS-stimulated HGFs. plantamajoside 30-44 interleukin 6 Homo sapiens 83-87 11583728-7 2001 These findings suggest that in addition to consistent improvement of exercise tolerance, cilostazol may improve lipid profiles by reducing IL-6 release. Cilostazol 89-99 interleukin 6 Homo sapiens 139-143 11562425-3 2001 Pretreatment of ASM cells with SB203580, a p38 MAPK inhibitor, slightly enhanced TNF alpha-induced ICAM-1 expression in a dose-dependent manner but partially inhibited secretion of RANTES and IL-6. SB 203580 31-39 interleukin 6 Homo sapiens 192-196 11281852-5 2001 Furthermore, there is now evidence that the thionamides interfere with thyrocyte expression of such molecules as Class I antigen, interleukin-1, interleukin-6, prostaglandin E2, and heat shock protein. thionamides 44-55 interleukin 6 Homo sapiens 145-158 11401420-4 2001 The p38 MAPK pathway is specifically involved in the combined agents-induced NO and IL-6 release, since NO and IL-6 release in the presence of a specific inhibitor of p38 MAPK, 4-(4-fluorophenyl)-2-(4-metylsulfinylphenyl)-5-(4-pyridyl)imidazole (SB203580), are significantly diminished. 4-(4-fluorophenyl)-2-(4-metylsulfinylphenyl)-5-(4-pyridyl)imidazole 177-244 interleukin 6 Homo sapiens 84-88 30913495-0 2019 Elevated plasma interleukin 6 predicts poor response in patients treated with sunitinib for metastatic clear cell renal cell carcinoma. Sunitinib 78-87 interleukin 6 Homo sapiens 16-29 11401420-4 2001 The p38 MAPK pathway is specifically involved in the combined agents-induced NO and IL-6 release, since NO and IL-6 release in the presence of a specific inhibitor of p38 MAPK, 4-(4-fluorophenyl)-2-(4-metylsulfinylphenyl)-5-(4-pyridyl)imidazole (SB203580), are significantly diminished. 4-(4-fluorophenyl)-2-(4-metylsulfinylphenyl)-5-(4-pyridyl)imidazole 177-244 interleukin 6 Homo sapiens 111-115 11401420-4 2001 The p38 MAPK pathway is specifically involved in the combined agents-induced NO and IL-6 release, since NO and IL-6 release in the presence of a specific inhibitor of p38 MAPK, 4-(4-fluorophenyl)-2-(4-metylsulfinylphenyl)-5-(4-pyridyl)imidazole (SB203580), are significantly diminished. SB 203580 246-254 interleukin 6 Homo sapiens 84-88 11502577-12 2001 However, epinephrine induced a small increase in IL-6 and may, therefore, partly influence the plasma levels of IL-6 during exercise. Epinephrine 9-20 interleukin 6 Homo sapiens 112-116 11424089-10 2001 Treatment with PI3K inhibitor, wortmannin or LY294002, abrogated not only PKCdelta translocation but the subsequent transcriptional activation of HSF and HIF-1 by hypoxia. Wortmannin 31-41 interleukin 6 Homo sapiens 146-149 11216681-17 2001 Inhibitors of protein synthesis (cyclohexamide) and intracellular protein transport (brefeldin A and monensin) blocked the release of interleukin-6, but none of these compounds influenced the suppressive effect of titanium on procollagen alpha1[I] gene expression. 4-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]piperidine-2,6-dione 33-46 interleukin 6 Homo sapiens 134-147 30321637-7 2019 After treated by Tri-DAP or MDP, the levels of IL-6 and TNF-alpha in peripheral blood were significantly lower in preterm and term newborns when comparing to adults. Acetylmuramyl-Alanyl-Isoglutamine 28-31 interleukin 6 Homo sapiens 47-51 11050083-8 2001 Rac1N17 also inhibited HSF activation by l-azetidine-2-carboxylic acid, a proline analog, and heavy metals (CdCl)), suggesting that Rac1 may be linked to HSF activation by denaturation of polypeptides in response to various proteotoxic stresses. L-Azetidine-2-carboxylic acid 41-70 interleukin 6 Homo sapiens 23-26 11050083-8 2001 Rac1N17 also inhibited HSF activation by l-azetidine-2-carboxylic acid, a proline analog, and heavy metals (CdCl)), suggesting that Rac1 may be linked to HSF activation by denaturation of polypeptides in response to various proteotoxic stresses. L-Azetidine-2-carboxylic acid 41-70 interleukin 6 Homo sapiens 154-157 11783106-2 2001 METHODS: The effect of IL-6 on the growth of U266 cells was shown by MTT; electrophoretic mobility shift assay (EMSA) was used to detect the activation of two transcription factors(TFs)-STAT3 and the NF-IL-6 by IL-6, which were involved in the JAK/STAT and Ras/NF-IL-6 signal transduction pathways. monooxyethylene trimethylolpropane tristearate 69-72 interleukin 6 Homo sapiens 23-27 30687454-4 2018 Methods and Results: Organic nitrates (ISMN, ISDN, and nitroglycerin (GTN)) augmented the oxidative burst and interleukin-6 release in cultured macrophages, whereas macitentan decreased the oxidative burst in isolated human leukocytes. Nitrates 29-37 interleukin 6 Homo sapiens 110-123 11154226-9 2001 IL-6-producing MCCs showed minimal spontaneous and dexamethasone-induced apoptosis, whereas a regular amplitude of apoptosis occurred in the IL-6(-) MCCs. mccs 15-19 interleukin 6 Homo sapiens 0-4 30687454-4 2018 Methods and Results: Organic nitrates (ISMN, ISDN, and nitroglycerin (GTN)) augmented the oxidative burst and interleukin-6 release in cultured macrophages, whereas macitentan decreased the oxidative burst in isolated human leukocytes. isosorbide-5-mononitrate 39-43 interleukin 6 Homo sapiens 110-123 11167428-6 2001 After 48 h, propofol caused significant increases in IL-1beta (24%), IL-6 (23%) and TNF-alpha (4.8 times) levels, while midazolam caused significant decreases in IL-1beta (21%), IL-6 (21%) and TNF-alpha (19%). Propofol 12-20 interleukin 6 Homo sapiens 69-73 11167428-9 2001 In conclusion, during 48 h of continuous infusion, propofol stimulated, while midazolam suppressed, the production of the pro-inflammatory cytokines IL-1beta, IL-6 and TNF-alpha, and both caused suppression of IL-8 production. Propofol 51-59 interleukin 6 Homo sapiens 159-163 11319753-5 2001 SB 203580, a selective inhibitor of p38 MAPK, inhibited IL-1 and TNF-induced p38 MAPK activity and IL-6 production (IC(50)s 0.3--0.5 microM) in osteoblasts and chondrocytes. SB 203580 0-9 interleukin 6 Homo sapiens 99-103 30687454-4 2018 Methods and Results: Organic nitrates (ISMN, ISDN, and nitroglycerin (GTN)) augmented the oxidative burst and interleukin-6 release in cultured macrophages, whereas macitentan decreased the oxidative burst in isolated human leukocytes. Nitroglycerin 55-68 interleukin 6 Homo sapiens 110-123 30687454-4 2018 Methods and Results: Organic nitrates (ISMN, ISDN, and nitroglycerin (GTN)) augmented the oxidative burst and interleukin-6 release in cultured macrophages, whereas macitentan decreased the oxidative burst in isolated human leukocytes. Nitroglycerin 70-73 interleukin 6 Homo sapiens 110-123 29644527-5 2018 In TNF-alpha-stimulated primary human coronary artery endothelial cells, both CRP and IL-6 productions were reduced by 70% at 2 mM gemcabene concentration. gemcabene 131-140 interleukin 6 Homo sapiens 86-90 11677783-0 2001 Phosphotyrosine profiling to identify novel components of interferon and interleukin 6-family cytokine signalling. Phosphotyrosine 0-15 interleukin 6 Homo sapiens 73-86 11885921-3 2001 Heavy metals like CdCl2 can induce, or inhibit the synthesis and expression of the inflammatory cytokines IL-1beta, IL-4, IL-6, TNF-alpha, IFN-gamma and ICAM-1. Cadmium Chloride 18-23 interleukin 6 Homo sapiens 122-126 29644527-6 2018 To investigate the mechanism of gemcabene-mediated reduction of CRP, transfection studies were performed with human CRP regulatory sequences in luciferase/beta-gal system that showed 25-fold increase in IL-6- and IL-6 plus IL-1beta-stimulated CRP transcription. gemcabene 32-41 interleukin 6 Homo sapiens 203-217 29644527-10 2018 In conclusion, gemcabene decreases CRP by C/EBP-delta and NF-kappaB-mediated transcriptional mechanism and suppresses IL-6 and IL-1beta-induced CRP production. gemcabene 15-24 interleukin 6 Homo sapiens 118-122 11028659-8 2000 Furthermore, PD98059 or SB203580 significantly suppressed BK-induced IL-6 and IL-8 production and their gene expression. SB 203580 24-32 interleukin 6 Homo sapiens 69-73 30205157-10 2018 IL-6 and GM-CSF secretion was decreased by inhibition of MK2 activity with MK2KR and while MK3WT had no effect, the kinase-deficient MK33A further decreased secretion of these mediators. mk33a 133-138 interleukin 6 Homo sapiens 0-4 11172736-0 2001 Signal transduction system for interleukin-6 and interleukin-11 synthesis stimulated by epinephrine in human osteoblasts and human osteogenic sarcoma cells. Epinephrine 88-99 interleukin 6 Homo sapiens 31-44 11172736-2 2001 An increase in IL-6 and IL-11 synthesis in response to epinephrine appeared to be a common feature in osteoblastic cells, but the magnitude of expression was different in these cell lines. Epinephrine 55-66 interleukin 6 Homo sapiens 15-19 11172736-6 2001 The findings of the present study suggest that coinduction of IL-6 and IL-11 in response to epinephrine probably occurs via the PKA and p38 MAPK systems, leading to the transcriptional activation of AP-1 in human osteoblastic cells. Epinephrine 92-103 interleukin 6 Homo sapiens 62-66 10924631-11 2000 Serum IL-6 levels increased after extubation in the MEA but not the CI group. mea 52-55 interleukin 6 Homo sapiens 6-10 30538676-0 2018 FGF23 Induction of O-Linked N-Acetylglucosamine Regulates IL-6 Secretion in Human Bronchial Epithelial Cells. o-linked n-acetylglucosamine 19-47 interleukin 6 Homo sapiens 58-62 11505786-9 2001 For instance, taurine chloramine inhibits the generation of macrophage inflammatory mediators such as nitric oxide, prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6). N-chlorotaurine 14-32 interleukin 6 Homo sapiens 185-198 30519664-0 2018 Fungal metabolite (+)-terrein suppresses IL-6/sIL-6R-induced CSF1 secretion by inhibiting JAK1 phosphorylation in human gingival fibroblasts. terrein 18-29 interleukin 6 Homo sapiens 41-45 11505786-9 2001 For instance, taurine chloramine inhibits the generation of macrophage inflammatory mediators such as nitric oxide, prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6). N-chlorotaurine 14-32 interleukin 6 Homo sapiens 200-204 11776203-7 2000 When danazol was added to the cell culture and reached 100 micrograms/L of concentration, the levels of TNF-alpha and IL-6 in cultured macrophage supernatant and the [Ca2+]i of macrophages in EM group decreased significantly (P < 0.01). Danazol 5-12 interleukin 6 Homo sapiens 118-122 10886590-12 2000 CONCLUSIONS: These results suggest an important role for poor dialysis biocompatibility of CU on the release of sIL-6R, which increases sIL-6R plasma levels, thereby enhancing the inflammatory effects of IL-6. sil-6r 136-142 interleukin 6 Homo sapiens 113-117 30519664-3 2018 We previously reported that (+)-terrein inhibited activation of STAT3 and ERK1/2 in interleukin-6 (IL-6) signaling cascade, leading to prevent vascular endothelial growth factor (VEGF) secretion in human gingival fibroblasts (HGFs). terrein 28-39 interleukin 6 Homo sapiens 84-97 30519664-3 2018 We previously reported that (+)-terrein inhibited activation of STAT3 and ERK1/2 in interleukin-6 (IL-6) signaling cascade, leading to prevent vascular endothelial growth factor (VEGF) secretion in human gingival fibroblasts (HGFs). terrein 28-39 interleukin 6 Homo sapiens 99-103 11130096-0 2000 The influence of cotinine on interleukin 6 expression in smokers with cervical preneoplasia. Cotinine 17-25 interleukin 6 Homo sapiens 29-42 30519664-5 2018 In this study, we provided the possibility of novel action that (+)-terrein inhibits activation of Janus-activated kinase 1 (JAK1), which has a central function in IL-6 signaling cascade, and alters expression of mRNAs and proteins induced by IL-6/soluble IL-6 receptor (sIL-6R) stimulation in HGFs. terrein 64-75 interleukin 6 Homo sapiens 164-168 10886221-2 2000 A combination of BE-8 [an anti-interleukin 6 (IL-6) murine monoclonal antibody] and dexamethasone followed by high-dose melphalan (220 mg/m2) and autologous stem cell transplantation was used to treat a series of 16 patients with advanced multiple myeloma. be-8 17-21 interleukin 6 Homo sapiens 31-44 10886221-2 2000 A combination of BE-8 [an anti-interleukin 6 (IL-6) murine monoclonal antibody] and dexamethasone followed by high-dose melphalan (220 mg/m2) and autologous stem cell transplantation was used to treat a series of 16 patients with advanced multiple myeloma. be-8 17-21 interleukin 6 Homo sapiens 46-50 10880753-11 2000 GD1a-induced increases of IL-6 and IL-10 production in monocytes were both blocked by Ca(2)+/calmodulin (CaM)-dependent phosphodiesterase (PDE) inhibitors, 8-methoxymethyl-3-isobutyl-1-methylxanthine and vinpocetin, but not by other signal-transducing enzyme inhibitors. 8-methoxymethyl-3-isobutyl-1-methylxanthine 156-199 interleukin 6 Homo sapiens 26-30 11218881-3 2000 Then the cells were transfected with the sense or anti-sense expression plasmids of the transcription factors, which could up- or down-regulate the activation of the signal transduction pathways specially, the changes of the biological function of IL-6 on XG-7 cells was shown by cell number counting and MTT. monooxyethylene trimethylolpropane tristearate 305-308 interleukin 6 Homo sapiens 248-252 11037876-0 2000 The mechanism of taurine chloramine inhibition of cytokine (interleukin-6, interleukin-8) production by rheumatoid arthritis fibroblast-like synoviocytes. Taurine 17-24 interleukin 6 Homo sapiens 60-73 30519664-5 2018 In this study, we provided the possibility of novel action that (+)-terrein inhibits activation of Janus-activated kinase 1 (JAK1), which has a central function in IL-6 signaling cascade, and alters expression of mRNAs and proteins induced by IL-6/soluble IL-6 receptor (sIL-6R) stimulation in HGFs. terrein 64-75 interleukin 6 Homo sapiens 243-269 30519664-7 2018 Treatment with (+)-terrein suppressed expression of mRNA and protein of CSF1 and VEGF by IL-6/sIL-6R stimulation. terrein 15-26 interleukin 6 Homo sapiens 89-93 30519664-9 2018 Western blotting revealed that (+)-terrein inhibited IL-6/sIL-6R-induced phosphorylation of JAK1, Akt, and SHP-2. terrein 31-42 interleukin 6 Homo sapiens 53-57 10798763-7 2000 Low concentrations of prednisolone (0.01 and 0.001 microg/ml) enhanced IL-6 and IL-8 secretion, whereas concentrations > or =0.01 microg/ml significantly diminished IL-6 secretion. Prednisolone 22-34 interleukin 6 Homo sapiens 71-75 30519664-10 2018 Therefore, (+)-terrein suppresses IL-6/sIL-6R-induced expression of CSF1 and VEGF via inhibition of JAK1, Akt, and SHP-2. terrein 11-22 interleukin 6 Homo sapiens 34-38 30519664-11 2018 Based on our results, we suggest that (+)-terrein is a candidate compound for anti-inflammatory effect associated with IL-6 signaling. terrein 38-49 interleukin 6 Homo sapiens 119-123 10679281-3 2000 The PolyG-MDP was found to trigger the secretion of higher levels of interleukin-6, interleukin-1alpha, TNF-alpha, and nitric oxide in comparison to free MDP. polyg-mdp 4-13 interleukin 6 Homo sapiens 69-82 11072780-0 2000 Changes in plasma concentrations of interleukin-6 and interleukin-1 receptor antagonists in response to adrenaline infusion in humans. Epinephrine 104-114 interleukin 6 Homo sapiens 36-49 11072780-5 2000 The plasma concentration of IL-6 had increased by two- to threefold after 45 min of adrenaline infusion (P<0.01) and was still elevated 1 h after the infusion had ended (P<0.001 and P<0.05 in controls and HIV infected patients, respectively). Epinephrine 84-94 interleukin 6 Homo sapiens 28-32 11072780-9 2000 The present study supports the existence of a relationship between the plasma concentration of adrenaline and IL-6. Epinephrine 95-105 interleukin 6 Homo sapiens 110-114 30114464-6 2018 Of note, the mRNA levels of IL-6 and IL-8 were approximately two-fold higher when cells were stimulated with 3 x 107 CFU/ml of r-SP for 3 h, while the protein levels of IL-6 and IL-8 were approximately five-fold higher after stimulation with 3 x 107 CFU/ml of r-SP for 24 h. Furthermore, r-SP exhibited potent activation of Toll-like receptor 2 compared with h-SP or f-SP. f-sp 367-371 interleukin 6 Homo sapiens 28-32 11072780-10 2000 It is possible that an increased adrenaline concentration in plasma induces a continued de novo synthesis of IL-6, thereby increasing plasma IL-6 in a time-dose dependent manner. Epinephrine 33-43 interleukin 6 Homo sapiens 109-113 11072780-10 2000 It is possible that an increased adrenaline concentration in plasma induces a continued de novo synthesis of IL-6, thereby increasing plasma IL-6 in a time-dose dependent manner. Epinephrine 33-43 interleukin 6 Homo sapiens 141-145 10579793-4 2000 The effects of wortmannin, an inhibitor of PI-3 kinase, and/or IL-6 on cell growth were assessed by MTT assays. monooxyethylene trimethylolpropane tristearate 100-103 interleukin 6 Homo sapiens 63-67 30114464-7 2018 The expression of IL-6 and IL-8 induced by r-SP was mediated through the activation of mitogen-activated protein kinases. r-sp 43-47 interleukin 6 Homo sapiens 18-22 10579793-9 2000 In contrast, wortmannin has no effect on LNCaP growth when used alone; however, combined with IL-6, wortmannin promotes apoptosis in these cells. Wortmannin 100-110 interleukin 6 Homo sapiens 94-98 30114464-9 2018 Taken together, we suggest that r-SP stimulates the human respiratory epithelial cells to produce the cytokines IL-6 and IL-8, which might influence the induction of adaptive immune responses. r-sp 32-36 interleukin 6 Homo sapiens 112-116 30384444-5 2018 To exert its anti-inflammatory/anti-oncogenic effects, farnesol can modulate Ras protein and nuclear factor kappa-light-chain-enhancer of activated B cells activation to downregulate the expression of various inflammatory mediators such as cyclooxygenase-2, inducible nitric oxide synthase, tumor necrosis factor alpha, and interleukin-6. Farnesol 55-63 interleukin 6 Homo sapiens 324-337 10490998-5 1999 Here, we report that other inflammatory cytokines (IL-1 alpha, IL-1 beta, and IL-6) are also neuroprotective to excessive NMDA challenge in our system. N-Methylaspartate 122-126 interleukin 6 Homo sapiens 78-82 10946280-8 2000 Interestingly, one SHP2-recruiting phosphotyrosine motif in a single chain of the gp130 dimer is sufficient to mediate SHP2 association to the gp130 receptor subunit and its tyrosine phosphorylation as well as to attenuate IL-6-dependent gene induction. Phosphotyrosine 35-50 interleukin 6 Homo sapiens 223-227 10989981-1 2000 The in vitro effect of cefotaxime on the production of interleukin (IL)-1beta, IL-2, IL-6 and tumor necrosis factor alpha (TNFalpha) was studied in term neonates and was compared with that of adults. Cefotaxime 23-33 interleukin 6 Homo sapiens 85-89 29902518-5 2018 Risperidone showed an anti-inflammatory activity, decreasing the release of tumor necrosis factor alpha (TNF-alpha), interleukins 1beta (IL-1 beta) and 6 (IL-6), and increasing interleukin 10 (IL-10). Risperidone 0-11 interleukin 6 Homo sapiens 155-159 10945640-7 2000 IFN-alpha as well as IL-6 prevented DEX plus alphaIGF-1R-induced apoptosis, and this prevention was blocked by the mitogen-activated protein kinase kinase inhibitor, PD098059, or the phosphatidylinositol 3-kinase inhibitor, wortmannin. Wortmannin 224-234 interleukin 6 Homo sapiens 21-25 10319886-6 1999 Conversely, treatment of PBMCs with the adenosine A1 receptor agonist R-phenylisopropyladenosine (R-PIA) (1 microM) significantly inhibited mitogen-stimulated production of TNF alpha but not IL-6 in control subjects and significantly inhibited production of IL-6 but not TNF alpha in MS patients. R-PIA 98-103 interleukin 6 Homo sapiens 258-262 10385244-10 1999 MK-571 mediated upregulation of IL-6 in the presence of IL-1 was partially attenuated by SB203580 and PD98059. SB 203580 89-97 interleukin 6 Homo sapiens 32-36 10069413-4 1999 IL-6 and IL-8 induction but not GM-CSF induction was inhibited in most of the RSF after pretreatment with AuTG. (3r,3as,6ar)-Hexahydrofuro[2,3-B]furan-3-Ol 78-81 interleukin 6 Homo sapiens 0-4 30096769-9 2018 Treatment with mycalolide B reduced cell-to-cell contact to build 3D formation and increased expression of actin cytoskeleton, resulting in increased IL-6 secretin. mycalolide B 15-27 interleukin 6 Homo sapiens 150-154 10037314-6 1999 RESULTS: Time courses of serum IL-6 levels in the preop GM group were significantly lower than those in the postop GM group. Gabexate 56-58 interleukin 6 Homo sapiens 31-35 10037314-12 1999 CONCLUSIONS: Reduction of systemic inflammatory response syndrome duration after esophagectomy by the continuous administration of gabexate mesilate started before operation may be through the suppression of TNF-alpha production capacity and Mac-1 expression on monocytes immediately after operation, and to suppression of increase in serum IL-6 level. Gabexate 131-148 interleukin 6 Homo sapiens 341-345 9852582-4 1998 Here, we show, using current- and voltage-clamp recordings, that chronic IL-6 treatment of developing cerebellar granule neurons increases the membrane and current response to NMDA and that these effects are the primary mechanism through which IL-6 produces an enhanced calcium signal to NMDA. N-Methylaspartate 288-292 interleukin 6 Homo sapiens 73-77 10913935-6 2000 IL-6 level was correlated with creatine phosphokinase (CPK) and FT(3) levels but not with FT(4 )or TSH levels in patients with AMI. ft(3) 64-69 interleukin 6 Homo sapiens 0-4 10957762-8 2000 In cultured respiratory epithelial cells, calcium oxalate increases the release of two interleukins (IL), IL-8 and IL-6, involved in granuloma formation by 8 to 10 fold within 24 hours. Calcium Oxalate 42-57 interleukin 6 Homo sapiens 115-119 10734320-6 2000 A pyrimidazole compound, SB203580, a specific inhibitor of p38 MAPK, inhibits production and gene expression of IL-6. SB 203580 25-33 interleukin 6 Homo sapiens 112-116 10734320-7 2000 SB203580 reduced significantly the stability of IL-6 mRNA. SB 203580 0-8 interleukin 6 Homo sapiens 48-52 9852582-4 1998 Here, we show, using current- and voltage-clamp recordings, that chronic IL-6 treatment of developing cerebellar granule neurons increases the membrane and current response to NMDA and that these effects are the primary mechanism through which IL-6 produces an enhanced calcium signal to NMDA. N-Methylaspartate 288-292 interleukin 6 Homo sapiens 244-248 29534802-8 2018 The limit of detection (LOD) obtained using both ionic liquids for IL-6 was 0.2 pg mL-1 with cross-reactivity studies indicating better performance of IL-6 detection using Choline[DHP] and no response to cross-reactive molecule. Choline 172-179 interleukin 6 Homo sapiens 151-155 9852582-5 1998 We also show that calcium influx through voltage-sensitive calcium channels contributes to the enhanced calcium signal to NMDA in the IL-6-treated neurons in a developmentally regulated manner and that the membrane depolarization to NMDA is more sensitive to the NMDA receptor antagonist ifenprodil in the IL-6-treated neurons compared with control neurons at a late developmental stage, consistent with a larger proportion of NMDA receptors containing the NMDAR2B subunit in the IL-6-treated neurons. N-Methylaspartate 122-126 interleukin 6 Homo sapiens 134-138 9852582-5 1998 We also show that calcium influx through voltage-sensitive calcium channels contributes to the enhanced calcium signal to NMDA in the IL-6-treated neurons in a developmentally regulated manner and that the membrane depolarization to NMDA is more sensitive to the NMDA receptor antagonist ifenprodil in the IL-6-treated neurons compared with control neurons at a late developmental stage, consistent with a larger proportion of NMDA receptors containing the NMDAR2B subunit in the IL-6-treated neurons. N-Methylaspartate 233-237 interleukin 6 Homo sapiens 134-138 9852582-5 1998 We also show that calcium influx through voltage-sensitive calcium channels contributes to the enhanced calcium signal to NMDA in the IL-6-treated neurons in a developmentally regulated manner and that the membrane depolarization to NMDA is more sensitive to the NMDA receptor antagonist ifenprodil in the IL-6-treated neurons compared with control neurons at a late developmental stage, consistent with a larger proportion of NMDA receptors containing the NMDAR2B subunit in the IL-6-treated neurons. N-Methylaspartate 233-237 interleukin 6 Homo sapiens 306-310 9852582-5 1998 We also show that calcium influx through voltage-sensitive calcium channels contributes to the enhanced calcium signal to NMDA in the IL-6-treated neurons in a developmentally regulated manner and that the membrane depolarization to NMDA is more sensitive to the NMDA receptor antagonist ifenprodil in the IL-6-treated neurons compared with control neurons at a late developmental stage, consistent with a larger proportion of NMDA receptors containing the NMDAR2B subunit in the IL-6-treated neurons. N-Methylaspartate 233-237 interleukin 6 Homo sapiens 306-310 10772282-6 2000 The in vitro production of IL-6 by MC in the two groups was not affected by the addition of IM. Methylcholanthrene 35-37 interleukin 6 Homo sapiens 27-31 10803978-3 2000 hIL-6 lacking the N-terminal Pro-Val-Pro-Pro was most efficiently secreted in a biologically active form and accumulated in the culture medium to a level of 200 mg per liter, which is the highest level reported for the bacterial secretion of hIL-6. pro-val-pro-pro 29-44 interleukin 6 Homo sapiens 0-5 29763588-5 2018 Intriguingly, LPS-induced high expression and generation of inflammatory cytokines (i.e., IL-6, TNF-alpha and IL-1beta) was notably reversed by glycyrrhizin pre-treatment. Glycyrrhizic Acid 144-156 interleukin 6 Homo sapiens 90-94 10741700-5 2000 The administration of a single dose of amifostine resulted in a reduction in tumor necrosis factor alpha and IL-6 transcript levels in the marrow cells of 10 of 13 and 12 of 13 patients in which these transcripts were present. Amifostine 39-49 interleukin 6 Homo sapiens 109-113 9733787-4 1998 SB203580 concentration-dependently inhibited protein production and gene expression of IL-6 by human FLSs. SB 203580 0-8 interleukin 6 Homo sapiens 87-91 9733787-6 1998 SB203580 significantly reduced the stability of IL-6 mRNA without affecting the rate of IL-6 gene transcription. SB 203580 0-8 interleukin 6 Homo sapiens 48-52 9734662-7 1998 Effects of RA + DEX were also least able to be overcome by exogenous IL-6. Radium 11-13 interleukin 6 Homo sapiens 69-73 9734662-9 1998 Since RPMI 8226 cells have undetectable IL-6, we investigated U266B1 cells and found that RA and DEX decreased both IL-6 secretion and IL-6 RNA levels. Radium 90-92 interleukin 6 Homo sapiens 40-44 9734662-9 1998 Since RPMI 8226 cells have undetectable IL-6, we investigated U266B1 cells and found that RA and DEX decreased both IL-6 secretion and IL-6 RNA levels. Radium 90-92 interleukin 6 Homo sapiens 116-120 9734662-9 1998 Since RPMI 8226 cells have undetectable IL-6, we investigated U266B1 cells and found that RA and DEX decreased both IL-6 secretion and IL-6 RNA levels. Radium 90-92 interleukin 6 Homo sapiens 116-120 29678503-6 2018 Cytokine levels of IL-8, MIP-1beta, IL-6, IFN-gamma, GM-CSF, TNF, IL-2, IL-4, MCP-1, and IL-10 were decreased significantly with caffeine treatment. Caffeine 129-137 interleukin 6 Homo sapiens 36-40 9734662-10 1998 Mechanistically, IL-6R down-regulation by RA was enhanced by DEX, whereas IL-6 protein and RNA levels were reduced by DEX and by RA. Radium 42-44 interleukin 6 Homo sapiens 17-21 9734662-11 1998 In summary, combinations of RA + DEX were not only more effective in inhibiting myeloma cells growth by the dual mechanisms of decreasing proliferative fraction and increasing apoptotic fraction, but were also less able to be overcome by IL-6. Radium 28-30 interleukin 6 Homo sapiens 238-242 24383530-10 2000 The addition of latex and polyethylene particles to human M/M resulted in a dose-dependent increase in IL-1beta, IL-6, and TNF-alpha release. Latex 16-21 interleukin 6 Homo sapiens 113-117 10690516-2 2000 Interleukin (IL)-1 alpha, IL-6, and IL-12 induction by ONO-4007 activates cytotoxic natural killer cells to up-regulate IFN-gamma and nitric oxide synthase activity. ONO 4007 55-63 interleukin 6 Homo sapiens 26-30 9804083-6 1998 After oral administration of prednisolone, the renal function improved, and the urinary IL-6 level was reduced. Prednisolone 29-41 interleukin 6 Homo sapiens 88-92 10690516-10 2000 ONO-4007 has a low systemic clearance (approximately 1.3 ml/min) and a small volume of distribution (5-8 liters) with a long t1/2 of 74-95 h. The administration of ONO-4007 was shown to result in a significant increase in circulating levels of tumor necrosis factor alpha and IL-6. ONO 4007 0-8 interleukin 6 Homo sapiens 276-280 10690516-10 2000 ONO-4007 has a low systemic clearance (approximately 1.3 ml/min) and a small volume of distribution (5-8 liters) with a long t1/2 of 74-95 h. The administration of ONO-4007 was shown to result in a significant increase in circulating levels of tumor necrosis factor alpha and IL-6. ONO 4007 164-172 interleukin 6 Homo sapiens 276-280 29758489-4 2018 Fisetin significantly inhibited COX-2 expression and reduced prostaglandin E2 production, and it suppressed the levels of IL-8, CCL5, monocyte chemotactic protein 1, tumor necrosis factor alpha, and IL-6. fisetin 0-7 interleukin 6 Homo sapiens 199-203 10854139-5 2000 Gemcitabine and to a lesser extent irinotecan inhibited the secretion of the proinflammatory cytokine IL-6 at concentrations of each drug that produced only small decreases in cell viability. gemcitabine 0-11 interleukin 6 Homo sapiens 102-106 10854139-7 2000 Higher doses of gemcitabine and irinotecan caused a surge in IL-6 release and this was not due to release of intracellular stores of IL-6 through lysis of the cells. gemcitabine 16-27 interleukin 6 Homo sapiens 61-65 10854139-8 2000 CONCLUSIONS: These results suggest that irinotecan and gemcitabine are not only more likely to be active against mesothelioma than other new chemotherapy agents but may also produce a palliative effect in nonresponders to these agents by decreasing the secretion of IL-6. gemcitabine 55-66 interleukin 6 Homo sapiens 266-270 9722036-0 1998 Effect of L-NAME, an inhibitor of nitric oxide synthesis, on plasma levels of IL-6, IL-8, TNF alpha and nitrite/nitrate in human septic shock. NG-Nitroarginine Methyl Ester 10-16 interleukin 6 Homo sapiens 78-82 9722036-1 1998 OBJECTIVES: We tested the effects of NG-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide (NO) synthesis, on plasma levels of interleukin (IL) IL-6, IL-8, tumor necrosis factor-alpha (TNFalpha) and nitrite/nitrate (NO2-/ NO3-) in patients with severe septic shock. NG-Nitroarginine Methyl Ester 71-77 interleukin 6 Homo sapiens 162-166 10611258-6 2000 The proteasome inhibitor MG132 (0.3 and 3 micromol/l) also caused a dose-dependent decrease in IL-1alpha and TNFalpha-stimulated IL-6 (P < 0.001 and P < 0.001 respectively) and leukaemia inhibitory factor (LIF) (P < 0. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 25-30 interleukin 6 Homo sapiens 129-133 29457280-8 2018 Besides, levels of PE750, PI885, PC792, PC826, PC830, PC854, PC802, and PG747 had an obvious negative correlation with levels of TNF-alpha, IL-10, IL-6, BUN, SCr, and PaCO2 , and a significant positive correlation with levels of HCO3- , PaO2 , and SaO2 . paco2 167-172 interleukin 6 Homo sapiens 147-151 10588509-6 1999 In blood of healthy volunteers, epinephrine reduced the LPS-stimulated synthesis of TNFalpha by 62.5% (P< 0.0001), of IL-6 by 39% (P< 0.0001), and of IL-1beta by 40% (P= 0.015), and increased the LPS-stimulated IL-10 production by 77.8% (P < 0.0001). Epinephrine 32-43 interleukin 6 Homo sapiens 121-125 9558859-4 1998 Body weight and water balance recovered earlier in group N. Postoperatively, numbers of peripheral lymphocytes and platelets changed lower in group H, while CRP and IL-6 changed higher in group H. Furthermore, a significant correlation was noted between the IL-6 level just after operation and peak-Bil (r = 0.669, p = 0.0006). bil 299-302 interleukin 6 Homo sapiens 258-262 9704149-7 1998 The spontaneous and LPS-induced activity of TNF-alpha and IL-6 were measured with bioassays using indicator cell lines WEHI-164.13 and 7TD1, respectively. lps 20-23 interleukin 6 Homo sapiens 58-62 29793168-5 2018 Oxysterols treatment significantly altered differentiated Caco-2 cells redox status, leading to oxidant species production and a decrease of GSH levels, after 1 h exposure, followed by an increase of cytokines production, IL-6 and IL-8, after 24 h. Oxysterol cell treatment also induced after 48 h an increase of NO release, due to the induction of iNOS. Oxysterols 0-10 interleukin 6 Homo sapiens 222-226 9704149-10 1998 Addition of LF to the cultures of LPS-activated mononuclear cells stimulated IL-6 production, most markedly in the group of septic survivor patients (mean 1479, 1452, 1728, 1980 pg/ml on day 1, 2, 3 and 6 respectively). lps 34-37 interleukin 6 Homo sapiens 77-81 9435177-3 1998 ONO-4007 induced slight production of TNF-alpha, Interleukin (IL)-1 beta, IL-6 and IL-12 in fresh monocytes but strongly induced TNF-alpha production in GM-CSF-treated monocytes. ONO 4007 0-8 interleukin 6 Homo sapiens 74-78 10534331-10 1999 Selective inhibition of either the p44/p42 MAPK pathway, by PD098059, or of the p38 MAPK pathway, by SB203580, blocked proliferation in response to IL-6. SB 203580 101-109 interleukin 6 Homo sapiens 148-152 10521086-7 1999 The median level of IL-6 was significantly higher in patients with RT than in patients with CT (40 pg/mL vs. 5 pg/mL; P<.001); however, there was no detectable difference in TPO and sIL-6 receptor levels between the two groups. ct 92-94 interleukin 6 Homo sapiens 20-24 29793168-5 2018 Oxysterols treatment significantly altered differentiated Caco-2 cells redox status, leading to oxidant species production and a decrease of GSH levels, after 1 h exposure, followed by an increase of cytokines production, IL-6 and IL-8, after 24 h. Oxysterol cell treatment also induced after 48 h an increase of NO release, due to the induction of iNOS. Oxysterols 0-9 interleukin 6 Homo sapiens 222-226 29731768-11 2018 The results showed that IL-6 inhibited TIMP3 expression in Saos2 and Saos2-lung cells via signal transducer and activator of transcription 3 (STAT3) activation. saos2 59-64 interleukin 6 Homo sapiens 24-28 10504489-11 1999 The role of these activations in IL-6 production was confirmed by the ability of both inhibitors SB203580 (1 to 30 microM) and PD98059 (0.01 to 10 microM) to inhibit basal and TNF-alpha-stimulated IL-6 production in both cell types. SB 203580 97-105 interleukin 6 Homo sapiens 33-37 10504489-11 1999 The role of these activations in IL-6 production was confirmed by the ability of both inhibitors SB203580 (1 to 30 microM) and PD98059 (0.01 to 10 microM) to inhibit basal and TNF-alpha-stimulated IL-6 production in both cell types. SB 203580 97-105 interleukin 6 Homo sapiens 197-201 10501085-4 1999 Maximal effect was achieved with leupeptin at 200 microM, with which the rate of IL-6 digestion was reduced to 50% that of control cells. leupeptin 33-42 interleukin 6 Homo sapiens 81-85 9489516-8 1998 By contrast, ibandronate enhanced LPS-induced secretion of IL-1beta and IL-6 but did not affect TNFalpha or NO secretion at non-cytotoxic concentrations. Ibandronic Acid 13-24 interleukin 6 Homo sapiens 72-76 29452068-5 2018 Here, we found that glycyrrhizin (20 or 40 muM) inhibited histamine-induced the mRNA expression and secretion of mucin 5 subtype AC (MUC5AC), interleukin (IL)-6 and IL-8 in HNEpCs. Glycyrrhizic Acid 20-32 interleukin 6 Homo sapiens 142-160 9412570-3 1997 We have demonstrated (1) similar constitutive TNF-alpha, IL-6, and soluble receptor production by control subjects and CBD patients, (2) a BeSO4-stimulated increase in TNF-alpha and IL-6 production by CBD-derived BAL cells, and (3) a BeSO4-induced decrease in sTNF RII production by BAL cells from control subjects. beryllium sulfate 139-144 interleukin 6 Homo sapiens 57-61 9412570-3 1997 We have demonstrated (1) similar constitutive TNF-alpha, IL-6, and soluble receptor production by control subjects and CBD patients, (2) a BeSO4-stimulated increase in TNF-alpha and IL-6 production by CBD-derived BAL cells, and (3) a BeSO4-induced decrease in sTNF RII production by BAL cells from control subjects. beryllium sulfate 139-144 interleukin 6 Homo sapiens 182-186 10438468-6 1999 Inhibition of PI 3-kinase by wortmannin or LY294002 abolished the protection of IL-6 against TGF-beta-induced apoptosis. Wortmannin 29-39 interleukin 6 Homo sapiens 80-84 10403520-7 1999 The DNA binding activity of the heat shock factor (HSF) in response to 20 microM CdCl2 exposure was also significantly lower in A2780CP cells. Cadmium Chloride 81-86 interleukin 6 Homo sapiens 32-49 10403520-7 1999 The DNA binding activity of the heat shock factor (HSF) in response to 20 microM CdCl2 exposure was also significantly lower in A2780CP cells. Cadmium Chloride 81-86 interleukin 6 Homo sapiens 51-54 10403520-8 1999 The treatment of A2780 cells with N-acetyl-L-cysteine increased the intracellular GSH concentration, and profoundly suppressed hsp72 mRNA induction and HSF activation by CdCl2. Cadmium Chloride 170-175 interleukin 6 Homo sapiens 152-155 9327312-10 1997 IL-6 in both groups reached its peak level at 2 hours postprotamine (208 [98 to 411] pg/mL in centrifugal versus 205 [60-327] pg/mL in the roller group), before coming back to baseline at 24 hours. postprotamine 54-67 interleukin 6 Homo sapiens 0-4 10403520-10 1999 Our findings suggest that increased GSH biosynthesis in CDDP-resistant cancer cells may be involved in the attenuation of HSF activation by CdCl2. Cadmium Chloride 140-145 interleukin 6 Homo sapiens 122-125 29067681-13 2018 Furthermore, using real-time reverse transcription-polymerase chain reaction beta-actin, fibronectin, interleukin-6 and IL-1b genes were confirmed as targets upregulated by IL-1beta and downregulated by chitosan-triclosan particles. Triclosan 212-221 interleukin 6 Homo sapiens 102-115 10456614-3 1999 Oncostatin-M- and interleukin-6-induced fibrinogen release was inhibited in a dose-dependent manner by ciprofibrate and, to lesser extent, by bezafibrate, fenofibric acid and clofibric acid. fenofibric acid 155-170 interleukin 6 Homo sapiens 18-31 9322065-4 1997 In peripheral blood mononuclear cells from 10 healthy donors, L-OspA at 10 micrograms ml-1 induced up to 4-fold more IL-1 beta, IL-6, and TNF-alpha than the other OspA preparations (P < or = 0.0068), followed by NS1-OspA, which was still superior to NL-OspA. l-ospa 62-68 interleukin 6 Homo sapiens 128-132 9322065-4 1997 In peripheral blood mononuclear cells from 10 healthy donors, L-OspA at 10 micrograms ml-1 induced up to 4-fold more IL-1 beta, IL-6, and TNF-alpha than the other OspA preparations (P < or = 0.0068), followed by NS1-OspA, which was still superior to NL-OspA. ospa 64-68 interleukin 6 Homo sapiens 128-132 29692858-10 2018 Dieckol and eckol attenuated the expression of inflammatory cytokines such as tumor necrosis factor- (TNF-) alpha, interleukin- (IL-) 1beta, IL-6, and IL-8 in human epidermal keratinocytes stimulated with PM10. dieckol 0-7 interleukin 6 Homo sapiens 141-145 9169347-6 1997 Rp-diastereoisomer of adenosine cyclic 3",5"-phosphorothioate (Rp-cAMPS) and H-8, inhibitors of PKA, significantly inhibited PTH-stimulated IL-6/IL-11 production, but did not inhibit IL-1-stimulated IL-6/IL-11 production. adenosine cyclic 3",5"-phosphorothioate 22-61 interleukin 6 Homo sapiens 140-144 9169347-6 1997 Rp-diastereoisomer of adenosine cyclic 3",5"-phosphorothioate (Rp-cAMPS) and H-8, inhibitors of PKA, significantly inhibited PTH-stimulated IL-6/IL-11 production, but did not inhibit IL-1-stimulated IL-6/IL-11 production. adenosine cyclic 3",5"-phosphorothioate 22-61 interleukin 6 Homo sapiens 199-203 10358197-4 1999 IL-1-induced IL-6 production was also suppressed by SB203580. SB 203580 52-60 interleukin 6 Homo sapiens 13-17 29417623-0 2018 Serum levels of interleukin 6 in schizophrenic patients during treatment augmentation with sarcosine (results of the PULSAR study). Sarcosine 91-100 interleukin 6 Homo sapiens 16-29 10326962-4 1999 RESULTS: Antazoline hydrochloride, emedastine difumarate, levocabastine hydrochloride, olopatadine hydrochloride, and pheniramine maleate attenuated histamine-stimulated phosphatidylinositol turnover and IL-6 and IL-8 secretion. Pheniramine 118-137 interleukin 6 Homo sapiens 204-208 9154894-10 1997 In the FOB group only patients who received local anesthesia by prilocaine bolus injection into the airways via the working channel of the bronchoscope developed fever and increases of IL-6 and IL-beta, whereas patients anaesthetized by inhalation of a prilocaine aerosol remained afebrile and had slight IL-6 increases only. Prilocaine 64-74 interleukin 6 Homo sapiens 185-189 29417623-1 2018 OBJECTIVE: Augmentation of sarcosine, a natural inhibitor of the glycine transporter type I, normalizes glutamatergic neurotransmission, having beneficial impact on primary negative symptoms in schizophrenia and may also influence immune system and interleukin 6 (IL-6) levels. Sarcosine 27-36 interleukin 6 Homo sapiens 249-262 10349502-4 1999 Levodopa caused an inhibition of mitogen-induced proliferation, stimulation of IL-6 and TNF-alpha production, whereas the secretion of IL-1 beta and IL-2 was not affected. Levodopa 0-8 interleukin 6 Homo sapiens 79-83 29417623-1 2018 OBJECTIVE: Augmentation of sarcosine, a natural inhibitor of the glycine transporter type I, normalizes glutamatergic neurotransmission, having beneficial impact on primary negative symptoms in schizophrenia and may also influence immune system and interleukin 6 (IL-6) levels. Sarcosine 27-36 interleukin 6 Homo sapiens 264-268 29417623-2 2018 AIM: Finding a relationship between initial IL-6 serum concentrations or its changes and severity of symptoms as a result of sarcosine addition to stable antipsychotic treatment. Sarcosine 125-134 interleukin 6 Homo sapiens 44-48 8913277-0 1996 Down regulation of protein kinase C during growth enhancement induced by interleukin-6 on a human myeloma cell line, KMS-11. kms-11 117-123 interleukin 6 Homo sapiens 73-86 29587260-10 2018 In a human monocyte THP-1 model, verbascoside could suppress DNCB-induced upregulation of CD86 and CD54 at the cell surface, the secretion of the proinflammatory cytokines TNF-alpha and IL-6, and the activation of NFkappaB signaling in a dose-dependent manner. acteoside 33-45 interleukin 6 Homo sapiens 186-190 8913277-5 1996 When exogenous IL-6 was added to KMS-11 culture, we observed (1) reduction of total PKC activity, and (2) translocation of PKC activity from its cytosol fraction to the membrane fraction. kms-11 33-39 interleukin 6 Homo sapiens 15-19 9832620-8 1998 SB203580, a specific inhibitor of p38 MAP kinase, significantly inhibited IL-1beta-induced IL-6 and stromelysin-1 production by both parental FLSs and MH7A cells; although PD098059, an inhibitor of the p42/p44 MAP kinase pathway, did not affect it. SB 203580 0-8 interleukin 6 Homo sapiens 91-95 29275239-5 2018 At the non photocytotoxic dose PFLX, shows reduced phagocytosis activity, NO (nitric oxide) production, large vacuole formation and down regulated IL-6, TNF-alpha and IL-1 in BALB/c macrophages at both genes and proteins levels. Pefloxacin 31-35 interleukin 6 Homo sapiens 147-151 9732406-3 1998 We now show that PGE2 and the EP4/EP2/EP3 R-selective agonist misoprostol, but not the EP3 R-directed agonists sulprostone and M&B28767, induced increases in HSB.2 T cell interleukin-6 (IL-6) mRNA and secretion. Misoprostol 62-73 interleukin 6 Homo sapiens 175-188 9732406-3 1998 We now show that PGE2 and the EP4/EP2/EP3 R-selective agonist misoprostol, but not the EP3 R-directed agonists sulprostone and M&B28767, induced increases in HSB.2 T cell interleukin-6 (IL-6) mRNA and secretion. Misoprostol 62-73 interleukin 6 Homo sapiens 190-194 9722934-6 1998 The anti-androgen cyproterone acetate acted as an androgen analogue in the gingival fibroblasts, potently inhibiting IL-6 production, and did not reverse the DHT-mediated downregulation of the cytokine. Cyproterone Acetate 18-37 interleukin 6 Homo sapiens 117-121 8943541-9 1996 Either spontaneous or cytokine-induced IL-6 secretion was inhibited by progesterone (10(-8)-10(-5) M) and danazol (10(-6) M), whereas oestradiol (10(-8)-10(-5) M) had a limited inhibitory effect. Danazol 106-113 interleukin 6 Homo sapiens 39-43 8761470-6 1996 We found that oxidizing agents, such as H2O2 and diamide, as well as alkylating agents, such as iodoacetic acid, abolished, in vitro, the HSF-DNA-binding activity induced by HS in vivo. Iodoacetic Acid 96-111 interleukin 6 Homo sapiens 138-141 8880223-12 1996 Citalopram was equality as potent as imipramine and clomipramine in inhibiting IL-6 release after long-term exposure of monocytes to LPS. Citalopram 0-10 interleukin 6 Homo sapiens 79-83 9826026-0 1998 SKW 6.4 cell differentiation induced by interleukin 6 is stimulated by butyrate. Butyrates 71-79 interleukin 6 Homo sapiens 40-53 29482476-6 2018 In addition, PFDA and PFUnA enhanced gene expression of pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8 by activation of nuclear factor-kappaB in IgE-stimulated mast cells. perfluorodecanoic acid 13-17 interleukin 6 Homo sapiens 151-155 9767413-2 1998 We previously reported that TauCl inhibits the generation of macrophage inflammatory mediators such as nitric oxide, prostaglandin E2 (PGE2), tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). N-chlorotaurine 28-33 interleukin 6 Homo sapiens 187-200 9767413-2 1998 We previously reported that TauCl inhibits the generation of macrophage inflammatory mediators such as nitric oxide, prostaglandin E2 (PGE2), tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). N-chlorotaurine 28-33 interleukin 6 Homo sapiens 202-206 8664339-7 1996 Other downstream targets for ceramide action include Cox, IL-6 and IL-2 gene expression, PKC zeta, Vav, Rb, c-Myc, c-Fos, c-Jun and other transcriptional regulators. Ceramides 29-37 interleukin 6 Homo sapiens 58-62 28842514-10 2017 The poly(I:C)-induced release of inflammatory mediators, including CXCL8, interleukin (IL)-6 and CXCL1, from ASMCs from cough patients was significantly impaired compared with healthy non-cough subjects. asmcs 109-114 interleukin 6 Homo sapiens 74-92 8617238-6 1996 Under the same conditions, SB203580 also completely inhibited TNF-induced synthesis of interleukin (IL)-6 and expression of a reporter gene that was driven by a minimal promoter containing two NF-Kappa B elements. SB 203580 27-35 interleukin 6 Homo sapiens 87-105 9452444-6 1998 We observed that the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580 was able to repress TNF-stimulated expression of the IL-6 gene, as well as of a kappaB-dependent reporter gene construct, without affecting the levels of NF-kappaB binding to DNA. SB 203580 75-83 interleukin 6 Homo sapiens 137-141 28666830-4 2017 The production of TNF-alpha, IL-1beta and IL-6 and their mRNA expression levels markedly decreased while the level and mRNA expression of IL-10 were elevated when the cells were treated with Sophora subprosrate polysaccharide. Polysaccharides 211-225 interleukin 6 Homo sapiens 42-46 9466577-5 1998 The objective of this study was to determine whether TNF-alpha activates the sphingomyelin pathway in human synovial fibroblasts (HSF) and the potential role of ceramide in HSF proliferation and apoptosis. Ceramides 161-169 interleukin 6 Homo sapiens 173-176 9466577-9 1998 Sphingomyelinase activation was determined by quantitation of sphingomyelin and ceramide radioactivity in [14C]serine-prelabeled HSF cells. Ceramides 80-88 interleukin 6 Homo sapiens 129-132 8567958-9 1996 149: 1153-1159), we observed that treatment with CP-105,696 inhibited the acute increase in bronchoalveolar lavage (BAL) levels of IL-6 and IL-8 by 56.9 +/- 13.2% and 46.9 +/- 14.5%, respectively, 4 h after challenge with Ascaris suum antigen (Ag). cp-105 49-55 interleukin 6 Homo sapiens 131-135 9466577-9 1998 Sphingomyelinase activation was determined by quantitation of sphingomyelin and ceramide radioactivity in [14C]serine-prelabeled HSF cells. Carbon-14 107-110 interleukin 6 Homo sapiens 129-132 28938160-8 2017 In line with this, nilotinib, especially in low doses, induced an upregulation of VEGF and IL-6 mRNA in the tumor cells in vitro, thus providing an explanation for the enhanced angiogenesis observed in nilotinib-treated tumors in vivo. nilotinib 19-28 interleukin 6 Homo sapiens 91-95 8787651-0 1996 Cannabinoids and interleukin-6 enhance the response to NMDA in developing CNS neurons. N-Methylaspartate 55-59 interleukin 6 Homo sapiens 17-30 8550818-4 1995 The synthetic ceramides C2- and C6-ceramide as well as the enzyme sphingomyelinase were able to induce IL-6 gene transcription and protein synthesis in a dose-dependent manner with maximal IL-6 mRNA levels being reached after 4 h of ceramide treatment. Ceramides 14-23 interleukin 6 Homo sapiens 189-193 8550818-4 1995 The synthetic ceramides C2- and C6-ceramide as well as the enzyme sphingomyelinase were able to induce IL-6 gene transcription and protein synthesis in a dose-dependent manner with maximal IL-6 mRNA levels being reached after 4 h of ceramide treatment. Ceramides 14-22 interleukin 6 Homo sapiens 103-107 8550818-4 1995 The synthetic ceramides C2- and C6-ceramide as well as the enzyme sphingomyelinase were able to induce IL-6 gene transcription and protein synthesis in a dose-dependent manner with maximal IL-6 mRNA levels being reached after 4 h of ceramide treatment. Ceramides 14-22 interleukin 6 Homo sapiens 189-193 9635030-0 1998 Taurine chloramine inhibits the production of superoxide anion, IL-6 and IL-8 in activated human polymorphonuclear leukocytes. N-chlorotaurine 0-18 interleukin 6 Homo sapiens 64-68 29049420-8 2017 Furthermore, DAPT and LiCl decreased production of IL-1beta, TNF-alpha, IL-6, iNOS, Cox2 and MCP-1; however, IL-10 expression was increased notably in LiCl treated cells. dapt 13-17 interleukin 6 Homo sapiens 72-76 9564633-7 1998 The aim of our study was to characterize the influence of selegiline on the biosynthesis of IL-1 beta, IL-6 and TNF in human peripheral blood mononuclear cells (PBMC) from healthy blood donors. Selegiline 58-68 interleukin 6 Homo sapiens 103-107 9359864-4 1997 The cell-permeable ceramide analogues C2 and C6 each greatly potentiated induction of both CRP and SAA mRNA by IL-6+IL-1beta but did not affect the responses of alpha-fibrinogen to IL-6 or to IL-6+IL-1beta. Ceramides 19-27 interleukin 6 Homo sapiens 111-115 9359864-7 1997 The ability of C2 and C6 to potentiate the effects of cytokines suggests that the sphingomyelin-ceramide pathway participates in induction of CRP and SAA by IL-6+IL-1beta under these experimental conditions, most likely by transducing the effects of IL-1beta. Ceramides 96-104 interleukin 6 Homo sapiens 157-161 7499964-7 1995 We have found that TauCl inhibited the generation of nitric oxide, prostaglandin E2, tumor necrosis factor alpha, and interleukin-6, but TauCl slightly enhanced the release of IL-1 alpha. N-chlorotaurine 19-24 interleukin 6 Homo sapiens 118-131 7473161-5 1995 LY303870 antagonized in vitro NK-1 receptor effects as demonstrated by blockade of SP-stimulated phosphoinositide turnover in UC-11 MG human astrocytoma cells (Ki = 1.5 nM) and interleukin-6 secretion from U-373 MG human astrocytoma cells (Ki = 5 nM). 1-(N-(2-methoxybenzyl)acetylamino)-3-(1H-indol-3-yl)-2-(N-(2-(4-(piperidin-1-yl)piperidin-1-yl)acetyl)amino)propane 0-8 interleukin 6 Homo sapiens 177-190 29049420-8 2017 Furthermore, DAPT and LiCl decreased production of IL-1beta, TNF-alpha, IL-6, iNOS, Cox2 and MCP-1; however, IL-10 expression was increased notably in LiCl treated cells. Lithium Chloride 22-26 interleukin 6 Homo sapiens 72-76 28779592-8 2017 Consistent with in vitro results, our in vivo and serologic studies showed psoralidin inhibited lipopolysaccharide induced bone resorption by suppressing the inflammatory cytokines: TNF-alpha and IL-6 expression, as well as the ratio of RNAKL : OPG. psoralidin 75-85 interleukin 6 Homo sapiens 196-200 8840334-3 1995 IL-6 and TNF alpha may also activate the HPA axis, and IL-6 activates cerebral indolamines. indolamine 79-90 interleukin 6 Homo sapiens 55-59 8576944-2 1995 Two Ca(2+)-channel blockers, Manidipine (Roth et al., 1992) and Verapamil (Walz et al., 1990) have been shown to induce the expression of the gene coding for interleukin-6 (IL-6). manidipine 29-39 interleukin 6 Homo sapiens 158-171 8576944-2 1995 Two Ca(2+)-channel blockers, Manidipine (Roth et al., 1992) and Verapamil (Walz et al., 1990) have been shown to induce the expression of the gene coding for interleukin-6 (IL-6). manidipine 29-39 interleukin 6 Homo sapiens 173-177 8576944-3 1995 Here we demonstrate that the four Ca(2+)-channel blockers, Amlodipine, Felodipine, Isradipine and Manidipine, at nanomolar concentrations, activate the transcription of the genes encoding IL-6 and IL-8 in primary human VSMC and fibroblasts. manidipine 98-108 interleukin 6 Homo sapiens 188-192 9427297-0 1997 Interleukin-6 attenuation of scopolamine-induced amnesia: plausible involvement of cholinergic neuronal survival. Scopolamine 29-40 interleukin 6 Homo sapiens 0-13 9104805-7 1997 The IL-6 requirement appeared to be specific for virus-type stimuli as the synthetic analogue of viral nucleic acid, polyinosinic-polycytidylic acid, also induced IL-6-dependent glucocorticoid release, but treatments with the bacterial product lipopolysaccharide and a non-immune physical restraint stressor elicited IL-6-independent responses. Poly I-C 117-148 interleukin 6 Homo sapiens 4-8 9104805-7 1997 The IL-6 requirement appeared to be specific for virus-type stimuli as the synthetic analogue of viral nucleic acid, polyinosinic-polycytidylic acid, also induced IL-6-dependent glucocorticoid release, but treatments with the bacterial product lipopolysaccharide and a non-immune physical restraint stressor elicited IL-6-independent responses. Poly I-C 117-148 interleukin 6 Homo sapiens 163-167 9104805-7 1997 The IL-6 requirement appeared to be specific for virus-type stimuli as the synthetic analogue of viral nucleic acid, polyinosinic-polycytidylic acid, also induced IL-6-dependent glucocorticoid release, but treatments with the bacterial product lipopolysaccharide and a non-immune physical restraint stressor elicited IL-6-independent responses. Poly I-C 117-148 interleukin 6 Homo sapiens 163-167 28664473-8 2017 The expression levels of VEGF, IL-6, and IL-10 also decreased in response to treatment with QTF or AZM. Azithromycin 99-102 interleukin 6 Homo sapiens 31-35 9524442-9 1997 P fimbriae that bind the globoseries of glycolipids cause the release of ceramides and activation of the ceramide signaling pathway which contributes to the IL-6 response. Ceramides 73-82 interleukin 6 Homo sapiens 157-161 9524442-9 1997 P fimbriae that bind the globoseries of glycolipids cause the release of ceramides and activation of the ceramide signaling pathway which contributes to the IL-6 response. Ceramides 73-81 interleukin 6 Homo sapiens 157-161 7555210-0 1995 Cefodizime modulates in vitro tumor necrosis factor-alpha, interleukin-6 and interleukin-8 release from human peripheral monocytes. cefodizime 0-10 interleukin 6 Homo sapiens 59-72 8564529-5 1995 The bradykinin B2 receptor antagonist icatebant (HOE 140) inhibited the bradykinin-induced IL-2 and IL-6 release. icatebant 38-47 interleukin 6 Homo sapiens 100-104 27932554-6 2017 Overall, our results suggest that EVT significantly increases IL-6, MCP-1, and TNF-alpha levels in the ischemic leg, but this effect is not associated with a higher rate of in-stent restenosis. EVT 34-37 interleukin 6 Homo sapiens 62-66 9816008-10 1995 These results show that multilamellar vesicle muramyl tripeptide phosphatidylethanolamine administration activates monocyte cytotoxicity and cytokine production (TNF-alpha, IL-6). muramyl 46-53 interleukin 6 Homo sapiens 173-177 9097072-6 1997 In addition, SVNI induced the secretion of the cytokines TNF-alpha and IL-6, the expression of adhesion molecules, and the production of the neurotrophic factor NGF. svni 13-17 interleukin 6 Homo sapiens 71-75 9120270-3 1997 SB 203580 significantly inhibited IL-1-stimulated IL-6, (30 to 50% at 1 microM) but not IL-8 production from human fibroblasts (gingival and dermal) and umbilical vein endothelial cells. SB 203580 0-9 interleukin 6 Homo sapiens 50-54 28829877-0 2017 Effect of Ganciclovir on IL-6 Levels Among Cytomegalovirus-Seropositive Adults With Critical Illness: A Randomized Clinical Trial. Ganciclovir 10-21 interleukin 6 Homo sapiens 25-29 8989833-2 1997 The NO synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME), inhibited interleukin (IL)-8 and IL-6 production in LPS-stimulated human whole blood in a dose-dependent manner. NG-Nitroarginine Methyl Ester 27-59 interleukin 6 Homo sapiens 103-107 8989833-2 1997 The NO synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME), inhibited interleukin (IL)-8 and IL-6 production in LPS-stimulated human whole blood in a dose-dependent manner. NG-Nitroarginine Methyl Ester 61-67 interleukin 6 Homo sapiens 103-107 7720709-4 1995 RA, but not these "dissociating" retinoids, induced transcription of an interleukin-6 promoter-based reporter gene transiently transfected into HeLa cells together with RARs. Radium 0-2 interleukin 6 Homo sapiens 72-85 28829877-2 2017 Objective: To determine whether ganciclovir prophylaxis reduces plasma interleukin 6 (IL-6) levels in CMV-seropositive adults who are critically ill. Design, Setting, and Participants: Double-blind, placebo-controlled, randomized clinical trial (conducted March 10, 2011-April 29, 2016) with a follow-up of 180 days (November 10, 2016) that included 160 CMV-seropositive adults with either sepsis or trauma and respiratory failure at 14 university intensive care units (ICUs) across the United States. Ganciclovir 32-43 interleukin 6 Homo sapiens 71-84 8989833-4 1997 IL-6 production was significantly inhibited only with the highest dose of L-NAME used. NG-Nitroarginine Methyl Ester 74-80 interleukin 6 Homo sapiens 0-4 28829877-2 2017 Objective: To determine whether ganciclovir prophylaxis reduces plasma interleukin 6 (IL-6) levels in CMV-seropositive adults who are critically ill. Design, Setting, and Participants: Double-blind, placebo-controlled, randomized clinical trial (conducted March 10, 2011-April 29, 2016) with a follow-up of 180 days (November 10, 2016) that included 160 CMV-seropositive adults with either sepsis or trauma and respiratory failure at 14 university intensive care units (ICUs) across the United States. Ganciclovir 32-43 interleukin 6 Homo sapiens 86-90 7796653-1 1995 By using ELISA and assay of MTT participating in IL-6 dependent cell clone. monooxyethylene trimethylolpropane tristearate 28-31 interleukin 6 Homo sapiens 49-53 28829877-7 2017 The mean change in plasma IL-6 levels between groups was -0.79 log10 units (-2.06 to 0.48) in the ganciclovir group and -0.79 log10 units (-2.14 to 0.56) in the placebo group (point estimate of difference, 0 [95% CI, -0.3 to 0.3]; P > .99). Ganciclovir 98-109 interleukin 6 Homo sapiens 26-30 28133767-9 2017 Activation of the IL-6-signal transducer and activator of transcription 3 pathway stimulated mIndy expression, enhanced cytoplasmic citrate influx, and augmented hepatic lipogenesis in vivo. Citric Acid 132-139 interleukin 6 Homo sapiens 18-22 9116194-0 1996 Selegiline stimulates biosynthesis of cytokines interleukin-1 beta and interleukin-6. Selegiline 0-10 interleukin 6 Homo sapiens 71-84 28551532-11 2017 Kynurenine (50-100muM) and tryptophan (50-100muM) decreased while tryptophan (5muM) and kynurenic acid (100muM) increased the release of IL-6. Kynurenic Acid 88-102 interleukin 6 Homo sapiens 137-141 8939386-2 1996 The bound IL-6 was visualized by reacting with anti-IL-6 antibody, a second biotinylated antibody to immunoglobulins, fluorescein-conjugated avidin and biotinylated, fluorescein-conjugated bovine serum albumin. Fluorescein 118-129 interleukin 6 Homo sapiens 10-14 8939386-2 1996 The bound IL-6 was visualized by reacting with anti-IL-6 antibody, a second biotinylated antibody to immunoglobulins, fluorescein-conjugated avidin and biotinylated, fluorescein-conjugated bovine serum albumin. Fluorescein 166-177 interleukin 6 Homo sapiens 10-14 8057147-4 1994 The IL-6 immunoreactivity in conditioned medium from three different meningioma cultures eluted from a Sephadex G-100 column was evidenced by a single peak corresponding to a molecular weight of about 32 kD. sephadex 103-117 interleukin 6 Homo sapiens 4-8 8283061-7 1994 Pretreatment of KS cells with poly (I:C) for 24 h followed by removal of the poly (I:C) led to high levels of IL-6 secreted into medium that induced proliferation in KS cells. Poly I-C 30-39 interleukin 6 Homo sapiens 110-114 8408066-4 1993 Surprisingly, IL-6 carrying a COOH-terminal extension of the amino acids Lys-Asp-Glu-Leu (KDEL) was not completely retained in the endoplasmic reticulum (ER). lysyl-aspartyl-glutamyl-leucine 73-88 interleukin 6 Homo sapiens 14-18 8277408-5 1993 Significant correlations were found between BI and IL-6 (P < 0.005) and between PD and IL-6 (P < 0.05), but not between PI and IL-6. Bismuth 44-46 interleukin 6 Homo sapiens 51-55 28687674-6 2017 Neuroinflammation studies revealed that the terminal epoxides 17,18-EEQ-EA and 19,20-EDP-EA dose-dependently abated proinflammatory IL-6 cytokines while increasing anti-inflammatory IL-10 cytokines, in part through cannabinoid receptor-2 activation. ea 72-74 interleukin 6 Homo sapiens 132-136 8316767-0 1993 Modulation of glucocorticosteroid binding in human lymphoid, monocytoid and hepatoma cell lines by inflammatory cytokines interleukin (IL)-1 beta, IL-6 and tumour necrosis factor (TNF)-alpha. glucocorticosteroid 14-33 interleukin 6 Homo sapiens 147-151 8803383-3 1996 Palliative steroid therapy with 20 mg/day of prednisolone resulted in the decline of serum IL-6 level and, simultaneously, improved anorexia and oral intake. Prednisolone 45-57 interleukin 6 Homo sapiens 91-95 8751470-2 1996 Spontaneous production of IL-6 by LNMC was detected in all four patients studied. lnmc 34-38 interleukin 6 Homo sapiens 26-30 28769800-10 2017 In addition, the PgLPS-induced increase in the IL-6 production by splenic CD11c+ cells was completely abolished by pre-treatment with FSLLRY-NH2, a PAR2 antagonist, as well as Akti, a specific inhibitor of Akt. H-Phe-Ser-Leu-Leu-Arg-Tyr-NH2 134-144 interleukin 6 Homo sapiens 47-51 8678641-7 1996 Interleukin-6 correlated with duration of extracorporeal circulation, dose of norepinephrine and epinephrine support, pulmonary capillary wedge pressure, mean pulmonary arterial pressure, right atrial pressure, heart rate, cardiac index, and inversely with systemic vascular resistance. Epinephrine 81-92 interleukin 6 Homo sapiens 0-13 7932624-6 1993 LPS stimulated IL-6 production showed similar patterns for TB patients, healthy and social controls (median values of 6806, 1291 and 2667 pg/10(6) cells respectively, p < 0.001). lps 0-3 interleukin 6 Homo sapiens 15-19 7932624-7 1993 In all three groups, LPS-stimulated cells produced significantly more IL-6 than non-stimulated cultures (p < 0.001). lps 21-24 interleukin 6 Homo sapiens 70-74 28955780-8 2017 RESULTS: Tensile strain and diacerein treatment reduced interleukin-6 (IL-6) expression, whereas cyclooxygenase-2 (COX2) expression was increased only by mechanical stimulation. diacerein 28-37 interleukin 6 Homo sapiens 56-69 1424289-5 1992 The MOCM from prednisolone-treated monocytes induced less SAA and CRP production by HepG2 cells; (ii) IL-1 alpha and IL-1 beta both induced CRP and SAA synthesis by HepG2 cells, but only in the presence of IL-6. Prednisolone 14-26 interleukin 6 Homo sapiens 206-210 8636270-5 1996 In contrast, serum IL-6 concentrations increased markedly 7 days after the treatment with prednisolone in all five patients and two of five patients showed further increases in serum IL-6 concentration on the 17th day. Prednisolone 90-102 interleukin 6 Homo sapiens 19-23 8636270-5 1996 In contrast, serum IL-6 concentrations increased markedly 7 days after the treatment with prednisolone in all five patients and two of five patients showed further increases in serum IL-6 concentration on the 17th day. Prednisolone 90-102 interleukin 6 Homo sapiens 183-187 28955780-8 2017 RESULTS: Tensile strain and diacerein treatment reduced interleukin-6 (IL-6) expression, whereas cyclooxygenase-2 (COX2) expression was increased only by mechanical stimulation. diacerein 28-37 interleukin 6 Homo sapiens 71-75 8635575-1 1996 Synthetic peptides immobilized on cellulose membranes proved to be a powerful tool for the identification of sites in the cytokine IL-6 involved in receptor binding. Cellulose 34-43 interleukin 6 Homo sapiens 131-135 1570335-1 1992 Manidipine, a Ca(2+)-channel blocker, at concentrations that lower elevated blood pressure, modulates the transcription rates of cytokine genes in the mesangial cells of humans that had been stimulated with platelet-derived growth factor BB isomer; although the transcription for mRNA of interleukin 1 beta and granulocyte/monocyte colony-stimulating factor was inhibited, the transcription of mRNA for interleukin 6 was enhanced. manidipine 0-10 interleukin 6 Homo sapiens 403-416 28499239-2 2017 Our recent study demonstrated that recombinant human endostatin (rhEndostatin) plays a key role in the inhibition of HSF proliferation in vitro, with a resulting decrease in dermal thickness and scar hypertrophy. rhendostatin 65-77 interleukin 6 Homo sapiens 117-120 1318656-7 1992 To evaluate a possible direct effect on the pituitary, IL-6 was incubated in vitro with hemipituitaries under an atmosphere of 95% O2/5% CO2. N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide 137-140 interleukin 6 Homo sapiens 55-59 8575817-6 1996 The presence of invariant amino acids within the receptor-binding portion of IL-6 for twelve different species suggests these positions are essential for biological activity of IL-6 and, moreover, likely account for the cross-reactivity among different mammalian IL-6-like activities in mouse bioassays. invariant amino acids 16-37 interleukin 6 Homo sapiens 77-81 8575817-6 1996 The presence of invariant amino acids within the receptor-binding portion of IL-6 for twelve different species suggests these positions are essential for biological activity of IL-6 and, moreover, likely account for the cross-reactivity among different mammalian IL-6-like activities in mouse bioassays. invariant amino acids 16-37 interleukin 6 Homo sapiens 177-181 8575817-6 1996 The presence of invariant amino acids within the receptor-binding portion of IL-6 for twelve different species suggests these positions are essential for biological activity of IL-6 and, moreover, likely account for the cross-reactivity among different mammalian IL-6-like activities in mouse bioassays. invariant amino acids 16-37 interleukin 6 Homo sapiens 177-181 8550818-3 1995 We have studied the effects of synthetic ceramides and sphingomyelinase as possible regulators of IL-6 gene expression in a human astrocytoma cell line. Ceramides 41-50 interleukin 6 Homo sapiens 98-102 28499239-4 2017 The present study was undertaken to directly examine the effect of rhEndostatin on HSF apoptosis in the rabbit ear model. rhendostatin 67-79 interleukin 6 Homo sapiens 83-86 8550818-4 1995 The synthetic ceramides C2- and C6-ceramide as well as the enzyme sphingomyelinase were able to induce IL-6 gene transcription and protein synthesis in a dose-dependent manner with maximal IL-6 mRNA levels being reached after 4 h of ceramide treatment. Ceramides 14-23 interleukin 6 Homo sapiens 103-107 1370390-7 1992 Hybridization with 32P-labeled oligonucleotides specific for the respective cytokine messenger RNAs (mRNAs) showed a 10-fold lower prevalence of transcripts for TNF, IL-1, and IL-6, as well. Phosphorus-32 19-22 interleukin 6 Homo sapiens 176-180 28499239-7 2017 Our data reveal that rhEndostatin (2.5 or 5mg/ml) induces HSF apoptotic cell death in scar tissue. rhendostatin 21-33 interleukin 6 Homo sapiens 58-61 28499239-9 2017 In sum, these results demonstrate that rhEndostatin induces HSF apoptosis, and this phenotypeis partially due to downregulation of NF-kappaB and bcl-2. rhendostatin 39-51 interleukin 6 Homo sapiens 60-63 1537055-2 1992 The addition of non-cytotoxic concentrations of Adriamycin (doxorubicin), vincristine and 4-OOH-cyclophosphamide (the in vitro active analogue of cyclophosphamide) resulted in suppression of IL-6 release. Cyclophosphamide 96-112 interleukin 6 Homo sapiens 191-195 7500647-2 1995 Gel retardation assays indicated that butyrate also stimulated heat-shock factor (HSF) binding activity between 3 and 6 h, suggesting that the activation of HSP70 gene expression was mediated by the heat-shock factor DNA response element (HSE). Butyrates 38-46 interleukin 6 Homo sapiens 63-80 28499239-10 2017 These findings suggest that rhEndostatin may have an inhibitory effect on scar hypertrophy in vivo via HSF apoptotic induction and therefore has potential therapeutic use for the treatment of HS. rhendostatin 28-40 interleukin 6 Homo sapiens 103-106 7500647-2 1995 Gel retardation assays indicated that butyrate also stimulated heat-shock factor (HSF) binding activity between 3 and 6 h, suggesting that the activation of HSP70 gene expression was mediated by the heat-shock factor DNA response element (HSE). Butyrates 38-46 interleukin 6 Homo sapiens 82-85 7500647-2 1995 Gel retardation assays indicated that butyrate also stimulated heat-shock factor (HSF) binding activity between 3 and 6 h, suggesting that the activation of HSP70 gene expression was mediated by the heat-shock factor DNA response element (HSE). Butyrates 38-46 interleukin 6 Homo sapiens 199-216 1303974-4 1992 The GMs of Cd-F were 43.9 and 37.0 micrograms/day for men and women, respectively, with boiled rice as a major source of cadmium (> 40%). gms 4-7 interleukin 6 Homo sapiens 11-15 1759822-0 1991 Differential modulation of cytokine production by macrolides: interleukin-6 production is increased by spiramycin and erythromycin. Erythromycin 118-130 interleukin 6 Homo sapiens 62-75 8549096-0 1995 The effect of auranofin and sulphasalazine therapy on circulating levels of interleukin 6 in rheumatoid arthritis patients. Sulfasalazine 28-42 interleukin 6 Homo sapiens 76-89 28442260-0 2017 Synthesis of benzoxazole derivatives as interleukin-6 antagonists. Benzoxazoles 13-24 interleukin 6 Homo sapiens 40-53 1759822-3 1991 We compared the in vitro effects of three macrolides (roxithromycin, spiramycin, and erythromycin) actively concentrated by leukocytes on interleukin-1 alpha, (IL-1 alpha), IL-1 beta, IL-6, and tumor necrosis factor alpha production by human monocytes stimulated with lipopolysaccharide. Erythromycin 85-97 interleukin 6 Homo sapiens 184-188 7660811-2 1995 METHODS: IL-6 was assayed using its dependent cell line MH60.BSF2 and measured by MTT spectrophotometry. monooxyethylene trimethylolpropane tristearate 82-85 interleukin 6 Homo sapiens 9-13 28442260-3 2017 This study reports that a series of synthetic derivatives of benzoxazole have suppressive effects on IL-6-mediated signaling. Benzoxazoles 61-72 interleukin 6 Homo sapiens 101-105 1905495-8 1991 In contrast, IL-6 secretion did not change after exercise, but dietary vitamin E supplementation significantly reduced IL-6 secretion throughout the 12-day period of observation (P = 0.023). Vitamin E 71-80 interleukin 6 Homo sapiens 119-123 28442260-4 2017 Among 16 synthetic derivatives of benzoxazole, the compounds 4, 6, 11, 15, 17, and 19 showed a strong suppressive activity against IL-6-induced phosphorylation of signal transducer and activator of transcription (STAT) 3 by 80-90%. Benzoxazoles 34-45 interleukin 6 Homo sapiens 131-135 2033081-2 1991 The 25-kDa O-glycosylated IL-6 (which contains only Ser- or Thr-GalNAc-Gal-NeuNAc and thus should not bind wheat germ or lentil lectins) bound to and was eluted from a wheat germ lectin affinity column by GlcNAc and from a lentil lectin affinity column by methyl-alpha-D-Man suggesting that the 25-kDa IL-6 species formed heteromeric complexes with the N-glycosylated 30-kDa IL-6. N-acetylgalactosaminuronic acid 64-70 interleukin 6 Homo sapiens 26-30 7834629-11 1995 Treatment of Caki-1 cells with anti-IL-6 mAb or anti-IL-6R mAb enhanced their sensitivity to carboplatin, but not to trans-diamminedichloroplatinum(II). Carboplatin 93-104 interleukin 6 Homo sapiens 36-40 2208307-6 1990 GM-CSF treatment enabled M phi to produce more interleukin (IL)-1 and IL-6 upon stimulation with lipopolysaccharides or polyinosinic-polycytidylic acid, but was unable to stimulate M phi directly. Poly I-C 120-151 interleukin 6 Homo sapiens 70-74 7731159-9 1995 Under these conditions short term exposure to PDF pH 5.2 followed by "in vitro dialysis" resulted in significant inhibition of cytokine stimulated IL-6 (69.6 +/- 18.2 vs. 96.7 +/- 27.9 pg/microgram, N = 13; P < 0.020 for IL-1 beta) and 6-keto-PGF1 alpha (197.5 +/- 89.2 vs. 289.6 +/- 114.5 pg/microgram, N = 13; P < 0.020 for IL-1 beta) and 6-keto-PGF1 alpha (197.5 +/- 89.2 vs. 289.6 +/- 114.5 pg/microgram, N = 13; P < 0.003) release when compared to cells incubated in control medium. 6-Ketoprostaglandin F1 alpha 239-256 interleukin 6 Homo sapiens 147-151 28442260-9 2017 These results suggest that a benzoxazole derivative, compound 4 effectively suppresses IL-6-STAT3 signaling and inflammatory cytokine production by T cells and provides a beneficial effect for treating chronic inflammatory and autoimmune disease. Benzoxazoles 29-40 interleukin 6 Homo sapiens 87-91 7731159-9 1995 Under these conditions short term exposure to PDF pH 5.2 followed by "in vitro dialysis" resulted in significant inhibition of cytokine stimulated IL-6 (69.6 +/- 18.2 vs. 96.7 +/- 27.9 pg/microgram, N = 13; P < 0.020 for IL-1 beta) and 6-keto-PGF1 alpha (197.5 +/- 89.2 vs. 289.6 +/- 114.5 pg/microgram, N = 13; P < 0.020 for IL-1 beta) and 6-keto-PGF1 alpha (197.5 +/- 89.2 vs. 289.6 +/- 114.5 pg/microgram, N = 13; P < 0.003) release when compared to cells incubated in control medium. 6-Ketoprostaglandin F1 alpha 347-364 interleukin 6 Homo sapiens 147-151 28333279-14 2017 In human foetal membranes, PIM1 inhibitors SMI-4a and AZD1208 significantly decreased the expression of pro-inflammatory cytokine interleukin-6 (IL6) and chemokines CXCL8 and CCL2 mRNA and release, prostaglandin prostaglandin F2alpha (PGF2alpha) release, adhesion molecule intercellular adhesion molecule 1 mRNA expression and release, and oxidative stress marker 8-isoprostane release after stimulation with either LPS or flagellin. AZD1208 54-61 interleukin 6 Homo sapiens 130-143 7915945-1 1994 IL-6 production by peripheral blood monocytes isolated from RA patients receiving the second-line drugs auranofin (AUR), sulphasalazine (SASP) or gold sodium aurothiomalate (GST) was investigated. Sulfasalazine 121-135 interleukin 6 Homo sapiens 0-4 2337412-2 1990 Utilizing classical Michaelis-Menten kinetics, apparent Km and Vmax values for HSF-PLA2 of 1.34 mM and 0.47 mumol [3H]palmitic acid released/min/mg protein were obtained using dipalmitoylphosphatidylcholine (DPPC) as the substrate, and 38.0 microM and 18.8 mumol [3H]arachidonic acid released/min/mg protein with Escherichia coli as a natural substrate. 1,2-Dipalmitoylphosphatidylcholine 176-206 interleukin 6 Homo sapiens 79-82 2337412-2 1990 Utilizing classical Michaelis-Menten kinetics, apparent Km and Vmax values for HSF-PLA2 of 1.34 mM and 0.47 mumol [3H]palmitic acid released/min/mg protein were obtained using dipalmitoylphosphatidylcholine (DPPC) as the substrate, and 38.0 microM and 18.8 mumol [3H]arachidonic acid released/min/mg protein with Escherichia coli as a natural substrate. 1,2-Dipalmitoylphosphatidylcholine 208-212 interleukin 6 Homo sapiens 79-82 2346722-11 1990 The stimulatory activities of MC appeared to be mediated through endogenously released IL-1, as the addition of antibodies towards IL-1 at the initiation of cocultures completely abrogated the IL-6 production. Methylcholanthrene 30-32 interleukin 6 Homo sapiens 193-197 28333279-14 2017 In human foetal membranes, PIM1 inhibitors SMI-4a and AZD1208 significantly decreased the expression of pro-inflammatory cytokine interleukin-6 (IL6) and chemokines CXCL8 and CCL2 mRNA and release, prostaglandin prostaglandin F2alpha (PGF2alpha) release, adhesion molecule intercellular adhesion molecule 1 mRNA expression and release, and oxidative stress marker 8-isoprostane release after stimulation with either LPS or flagellin. AZD1208 54-61 interleukin 6 Homo sapiens 145-148 10862623-1 2000 Modulation of HSF by vanadate and wortmannin. Wortmannin 34-44 interleukin 6 Homo sapiens 14-17 7944637-10 1994 After treatment with prednisolone, levels of serum IL-6 decreased significantly, but the circadian rhythm remained. Prednisolone 21-33 interleukin 6 Homo sapiens 51-55 28599489-0 2017 Maslinic acid suppresses the growth of human gastric cells by inducing apoptosis via inhibition of the interleukin-6 mediated Janus kinase/signal transducer and activator of transcription 3 signaling pathway. maslinic acid 0-13 interleukin 6 Homo sapiens 103-116 7522684-5 1994 Furthermore, there is now evidence that the thionamides interfere with thyrocyte expression of Class I antigen, interleukin-1, interleukin-6, prostaglandin E2, and heat shock protein. thionamides 44-55 interleukin 6 Homo sapiens 127-140 7516173-6 1994 A greater than 95% decrease in IL-6 production was seen with 10(-6) and 10(-7) M dexamethasone, prednisolone, and hydrocortisone, and IC50 values for these agents were approximately 5 x 10(-10), 5 x 10(-9), and 10(-8) M, respectively. Prednisolone 96-108 interleukin 6 Homo sapiens 31-35 34929480-7 2022 Further, POH treatment has decreased the pro-inflammatory serum cytokine levels such as IL-6, IL-12/23, TNF-alpha and IL-1beta and also reduced the expression levels of various inflammatory proteins, COX-2, iNOS, IL-17A, IL-22, NF-kB and STAT3 evidenced by Immunoblotting studies from skin samples. perillyl alcohol 9-12 interleukin 6 Homo sapiens 88-92 34971958-10 2022 The p38 inhibitor SB203580 inhibited the secretion of IL-8, slightly inhibited the secretion of IL-6, and did not affect NF-kappaB activity. SB 203580 18-26 interleukin 6 Homo sapiens 96-100 28599489-7 2017 Maslinic acid treatment also resulted in the downregulation of phosphorylated-STAT3 and JAK2, and significantly inhibited the protein expression of IL-6. maslinic acid 0-13 interleukin 6 Homo sapiens 148-152 28599489-8 2017 Maslinic acid is able to inhibit MKN28 cell proliferation and the phosphorylation of STAT3 by downregulating the expression of IL-6. maslinic acid 0-13 interleukin 6 Homo sapiens 127-131 28599489-9 2017 These results suggest that maslinic acid suppresses the growth of MKN28 cells by inducing apoptosis via its inhibition of the IL-6/JAK/STAT3 signaling cascade. maslinic acid 27-40 interleukin 6 Homo sapiens 126-130 7520955-6 1994 Functional studies on IL-6-dependent B9 cell proliferation were performed with IL-6 autoantibody positive sera, and quantitated with the colorimetric MTT assay. monooxyethylene trimethylolpropane tristearate 150-153 interleukin 6 Homo sapiens 22-26 28338993-5 2017 In addition, DHCE could inactivate the expression of interleukin (IL)-6 and downregulate the phosphorylation of extracellular regulated protein kinases (ERK1/2) and the signal transducer and activator of transcription 3 (STAT3) in MM. dhce 13-17 interleukin 6 Homo sapiens 53-71 8161348-2 1994 Treatment of cells with IL-6 decreased the level of 3-methylcholanthrene-induced CYPIA1 protein and its mRNA. Methylcholanthrene 52-72 interleukin 6 Homo sapiens 24-28 8307982-11 1994 These results indicate that G(Anh)MTetra induces IL-1 beta and IL-6 expression in human monocytes suggesting a possible role for G(Anh)MTetra in the release of cytokines during sepsis. disaccharide tetrapeptide 28-40 interleukin 6 Homo sapiens 63-67 34895310-9 2021 Among these JAKi, baricitinib was the most potent regulator for IFN-gamma-induced IL-6 production in human neutrophils. baricitinib 18-29 interleukin 6 Homo sapiens 82-86 34536521-14 2021 GSVA suggested that growth factor binding, IL2-stat5 signalling, and IL6-jak-stat3 signalling were crucial in the development of PD. gsva 0-4 interleukin 6 Homo sapiens 69-72 7979562-4 1994 We also investigated the effect of treatment with Danazol on the levels of SIL-2R, IL-6 and IL-1a in women with endometriosis. Danazol 50-57 interleukin 6 Homo sapiens 83-87 28338993-11 2017 Taken together, the results of our present study indicated that DHCE could inhibit cellular proliferation and induce cell apoptosis in myeloma cells mediated through different mechanisms, possibly through inhibiting the IL-6/STAT3 and ERK1/2 pathways. dhce 64-68 interleukin 6 Homo sapiens 220-224 28288823-13 2017 Upregulation of cadmium-induced IL-6 was inhibited by U0126 and SC-514, but not SB203580. U 0126 54-59 interleukin 6 Homo sapiens 32-36 8091149-4 1994 After prednisolone was administered, her IL-6 level decreased and the symptoms of MCTD, MCD, and CFS all improved. Prednisolone 6-18 interleukin 6 Homo sapiens 41-45 34546593-10 2021 In PI vs PM, significantly higher REL was found for Hey 1, TNF-alpha, IL-17, IL-1beta, IL-6 and RANKL. pipermethystine 9-11 interleukin 6 Homo sapiens 87-91 28189686-7 2017 Moreover, the effect of colchicine on cell death was enhanced in cells overexpressing two IL-8 up-regulators, NF-kappaB and IL-6, but not in cells overexpressing an IL-8 down-regulator, splicing factor proline/glutamine-rich (SFPQ). Colchicine 24-34 interleukin 6 Homo sapiens 124-128 34731782-10 2021 Liquiritin protected HaCaT cells against LPS-aroused inflammatory damage through increasing cell viability, decreasing cell apoptosis, and reducing IL-6, TNF-alpha and Cox-2 expressions. liquiritin 0-10 interleukin 6 Homo sapiens 148-152 34893117-10 2021 QPCR and Western blot showed that the arsenous acid, artesunate, and their combination treatment could inhibit the expression of mRNA and protein of cell proliferation-related factors interleukin-6 and vascular endothelial growth factor (P<0.05), inhibit apoptosis-related factor BCL-xl and promote the expression of mRNA and protein of Bax (P<0.05), and reduce the protein expression of p-PI3K and p-AKT in PI3K/AKT signaling pathway (P<0.05). arsenous acid 38-51 interleukin 6 Homo sapiens 184-197 7511248-6 1993 There were significant and positive correlations between Il-6 activity and postdexamethasone cortisol values. postdexamethasone 75-92 interleukin 6 Homo sapiens 57-61 28287093-6 2017 HDL that increased IL-6 secretion were enriched in ApoC-III, di-sialylated glycans at multiple A1AT glycosylation sites and desialylated A2HSG, and depleted in mono-sialylated ApoC-III (ApoC-III1). Polysaccharides 75-82 interleukin 6 Homo sapiens 19-23 8507933-2 1993 The IL-6 and CRP levels, which were extremely high before treatment, declined rapidly with corticosteroid and cyclophosphamide. Cyclophosphamide 110-126 interleukin 6 Homo sapiens 4-8 8492420-12 1993 Treatment with prednisolone and melphalan resulted in improvement of clinical findings such as anemia, lymph node swelling and hypergammaglobulinemia in concurrence with decrease in serum levels of IL-6. Prednisolone 15-27 interleukin 6 Homo sapiens 198-202 34757578-9 2022 Meanwhile, the most effective corticosteroid, interleukin-6 antagonist, and Janus kinase (JAK) inhibitor were hydrocortisone, sarilumab, and ruxolitinib, respectively. ruxolitinib 141-152 interleukin 6 Homo sapiens 46-59 34889899-10 2021 The MDT confirmed that two key activators (beta-Amyrone, beta-Stigmasterol) bound most stably to PPARA, PPARD, PPARG, FABP3, FABP4, and NR1H3 on the PPAR signaling pathway, also, three key inhibitors (Neotocopherol, Xanthosine, and beta-Amyrone) bound most tightly to AKT1, IL6, FGF2, and PHLPP1 on the PI3K-Akt signaling pathway. beta-amyrenone 232-244 interleukin 6 Homo sapiens 274-277 28243095-0 2017 Influence of fluvoxamine on plasma interleukin-6 or clinical improvement in patients with major depressive disorder. Fluvoxamine 13-24 interleukin 6 Homo sapiens 35-48 34732786-4 2021 Through an unbiased screen, we found that carboplatin rescued TNF-alpha and IL-6 production in LPS-tolerant macrophages. Carboplatin 42-53 interleukin 6 Homo sapiens 76-80 8418469-9 1993 However, poly(I)-poly(C) (a potent inducer of IL-6) also showed AEF activity, suggesting that not a single cytokine but rather a certain combination of different cytokines could be decisive in AA amyloidogenesis. Poly I-C 9-24 interleukin 6 Homo sapiens 46-50 28243095-3 2017 The aim of this study is to investigate the effects of fluvoxamine on plasma interleukin-6 (IL-6) levels and on clinical improvement of the depressive state. Fluvoxamine 55-66 interleukin 6 Homo sapiens 77-90 28243095-3 2017 The aim of this study is to investigate the effects of fluvoxamine on plasma interleukin-6 (IL-6) levels and on clinical improvement of the depressive state. Fluvoxamine 55-66 interleukin 6 Homo sapiens 92-96 1394624-5 1992 Although HNE is known to be a sulfhydryl blocking agent, the results obtained with N-ethylmaleimide suggest that different mechanisms might be involved in the in vitro activation of HSF by HNE. Ethylmaleimide 83-99 interleukin 6 Homo sapiens 182-185 34909094-3 2021 A new therapeutic approach using the immunomodulatory drug, Anti-IL6 (tocilizimub), has been proposed to regulate it. tocilizimub 70-81 interleukin 6 Homo sapiens 65-68 1323342-11 1992 Pretreatment of cells with cyclohexamide before exposure to LTB4 superinduced IL-6 message expression, but partially inhibited the effect of LTB4 on IL-6 mRNA accumulation, suggesting that newly synthesized proteins may be involved in the transcriptional activation of the IL-6 gene by LTB4. 4-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]piperidine-2,6-dione 27-40 interleukin 6 Homo sapiens 78-82 1323342-11 1992 Pretreatment of cells with cyclohexamide before exposure to LTB4 superinduced IL-6 message expression, but partially inhibited the effect of LTB4 on IL-6 mRNA accumulation, suggesting that newly synthesized proteins may be involved in the transcriptional activation of the IL-6 gene by LTB4. 4-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]piperidine-2,6-dione 27-40 interleukin 6 Homo sapiens 149-153 1323342-11 1992 Pretreatment of cells with cyclohexamide before exposure to LTB4 superinduced IL-6 message expression, but partially inhibited the effect of LTB4 on IL-6 mRNA accumulation, suggesting that newly synthesized proteins may be involved in the transcriptional activation of the IL-6 gene by LTB4. 4-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]piperidine-2,6-dione 27-40 interleukin 6 Homo sapiens 149-153 28243095-11 2017 CONCLUSION: Effect of fluvoxamine on IL-6 is partially associated with its clinical efficacy for MDD. Fluvoxamine 22-33 interleukin 6 Homo sapiens 37-41 34859864-7 2021 A positive correlation existed between BOP and all the three biomarkers RF (r=0.0562; p=0.0039), IL-6 and TNF-alpha for Group-II patients. bop 39-42 interleukin 6 Homo sapiens 97-101 28178219-5 2017 Reporter assays revealed that altholactone repressed p65- and TNF-alpha-enhanced NF-kappaB transcriptional activity and also inhibited both constitutive and IL-6-induced transcriptional activity of STAT3. altholactone 30-42 interleukin 6 Homo sapiens 157-161 34859864-8 2021 Similarly, a significant positive correlation existed between BOP and all the three biomarkers RF, IL-6 and TNF-alpha for Group-III patients. bop 62-65 interleukin 6 Homo sapiens 99-103 1874565-0 1991 Interleukin 6 is secreted by breast fibroblasts and stimulates 17 beta-oestradiol oxidoreductase activity of MCF-7 cells: possible paracrine regulation of breast 17 beta-oestradiol levels. beta-oestradiol 66-81 interleukin 6 Homo sapiens 0-13 2007786-6 1991 Addition of hydrocortisone, prednisolone, or dexamethasone immediately after UVB irradiation significantly blocked UVB or IL-1-induced IL-6 mRNA expression and production by EC. Prednisolone 28-40 interleukin 6 Homo sapiens 135-139 28035387-10 2017 Additionally, levels of IL-6 and IL-8 were significantly decreased by prednisone, ibuprofen and betamethasone. Prednisone 70-80 interleukin 6 Homo sapiens 24-28 34331010-9 2021 Participants treated with CBD had lower levels of interleukin-6 (p = 0.017), vascular endothelial growth factor (p = 0.032), intermediate monocytes CD14+CD16+ (p = 0.024), and natural killer CD56negCD16hi (p = 0.000) compared with participants receiving placebo. Cannabidiol 26-29 interleukin 6 Homo sapiens 50-63 28035387-12 2017 In combination with IL-6 or IL-8, prednisone, ibuprofen and betamethasone significantly reduced the levels of collagen I, MMP-1 and MMP-13, and inactivated NF-kappaB and STAT3 pathways. Prednisone 34-44 interleukin 6 Homo sapiens 20-24 28675894-5 2017 RESULTS: The analyzed interleukin 6 (IL6) gene cytosine phosphate guanine (CpG) islands showed a hypomethylation, while serum IL-6 was higher in the low compared to the high oxygen consumption group (p < 0.05). cytosine phosphate guanine 47-73 interleukin 6 Homo sapiens 22-35 34771621-4 2021 In this study, we show that gemcitabine stimulates the expression of pro-inflammatory cytokines, such as IL6 and IL8, under the influence of the CD95/CD95L system and the pharmacological inhibitor, sCD95Fc, substantially reduced the expression in two PDAC cell lines, PancTuI-luc and A818-4. gemcitabine 28-39 interleukin 6 Homo sapiens 105-108 34746302-16 2021 The hub components possibly include quercetin, stigmasterol, kaempferol, and beta-sitosterol and act through pairing with hub targets, such as AKT1, VEGFA, and IL6, to regulate neuronal death, G protein-coupled amine receptor activity, reactive oxygen species metabolic process, membrane raft, MAPK signaling pathway, and cellular senescence for the treatment of PD. Stigmasterol 47-59 interleukin 6 Homo sapiens 160-163 1715713-5 1991 The mean serum IL-6 levels measured by a hybridoma growth assay (B9) were 23 +/- 4 U/ml before therapy and fell to 16 +/- 3 U/ml after treatment with prednisolone. Prednisolone 150-162 interleukin 6 Homo sapiens 15-19 2269476-3 1990 Lipopylosaccharide (LPS) or Borrelia burgdorferi spirochetes (Bb) were used to induce TNF-alpha and IL-6 production in cultures. lps 20-23 interleukin 6 Homo sapiens 100-104 2269476-6 1990 IL-6 was produced by 64 +/- 8% or 71 +/- 9% (means +/- SD) of the non-IVIg-exposed monocytes after LPS or Bb stimulation, respectively (n = 12). lps 99-102 interleukin 6 Homo sapiens 0-4 2269476-6 1990 IL-6 was produced by 64 +/- 8% or 71 +/- 9% (means +/- SD) of the non-IVIg-exposed monocytes after LPS or Bb stimulation, respectively (n = 12). boeravinone B 106-108 interleukin 6 Homo sapiens 0-4 28675894-5 2017 RESULTS: The analyzed interleukin 6 (IL6) gene cytosine phosphate guanine (CpG) islands showed a hypomethylation, while serum IL-6 was higher in the low compared to the high oxygen consumption group (p < 0.05). cytosine phosphate guanine 47-73 interleukin 6 Homo sapiens 37-40 2269476-8 1990 In these cultures 24 +/- 12% or 29 +/- 12% of the monocytes made IL-6 in response to LPS or Bb. lps 85-88 interleukin 6 Homo sapiens 65-69 34607464-3 2021 Here, we show that tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) autocrine/paracrine signaling contributes to controlling the intracellular growth of M. avium in human primary macrophages through activation of IRF1 nuclear translocation and expression of IRG1, a mitochondrial enzyme that produces the antimicrobial metabolite itaconate. itaconic acid 346-355 interleukin 6 Homo sapiens 78-82 2269476-8 1990 In these cultures 24 +/- 12% or 29 +/- 12% of the monocytes made IL-6 in response to LPS or Bb. boeravinone B 92-94 interleukin 6 Homo sapiens 65-69 29055943-4 2017 METHODS: The human airway epithelial cell line 16HBE was used to test the effects of the SIRT1 inhibitor (salermide) on expression of IL-6. N-(3-((2-hydroxynaphthalen-1-ylmethylene)amino)phenyl)-2-phenylpropionamide 106-115 interleukin 6 Homo sapiens 134-138 2337412-4 1990 Inhibition of HSF-PLA2 by MLD was concentration and time dependent with IC50 values of 0.2 and 0.02 microM for DPPC and E. coli respectively. 1,2-Dipalmitoylphosphatidylcholine 111-115 interleukin 6 Homo sapiens 14-17 2310829-6 1990 As judged by sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reducing conditions, IL-6 species of relative molecular mass of 19 to 26 Kd could be specifically immunoprecipitated from supernatants of IL-1-induced monocytes. polyacrylamide gels 36-54 interleukin 6 Homo sapiens 98-102 34666750-10 2021 LABA/GCS attenuation of Poly I:C or imiquimod-induced IL-6 and IL-8 were potentiated with ABCC4 and PDE4 inhibition, which was greater when ABCC4 and PDE4 inhibition was combined. Imiquimod 36-45 interleukin 6 Homo sapiens 54-58 29558759-5 2017 Thus, the main aim of this clinical trial study was to determine the effects of treatment with risperidone and quetiapine, as antipsychotic drugs, with and without vitamin B12 on the psychotic symptoms of AD patients and the expression of IL-6, IL-8, tumor growth factor (TGF)-beta, tumor necrosis factor (TNF)-alpha, and endothelin (ET)-1). Risperidone 95-106 interleukin 6 Homo sapiens 239-243 34665696-7 2021 RESULTS: Baricitinib inhibited OSM-induced JAK signalling in RA synovial fibroblasts and effectively suppressed subsequent expression of the proinflammatory mediators IL-6, MCP-1 and IP-10. baricitinib 9-20 interleukin 6 Homo sapiens 167-171 34608123-6 2021 The reduced acetyl-CoA level suppresses H3K9Ac-mediated expression of the host proinflammatory cytokine Il6, thus promoting granuloma progression. Acetyl Coenzyme A 12-22 interleukin 6 Homo sapiens 104-107 34570917-13 2022 IFN-beta, TNF, and IL-6 production were also induced by transfection of bacterial and host cyclic dinucleotides or bacteria DNA. cyclic dinucleotides 91-111 interleukin 6 Homo sapiens 19-23 34570917-16 2022 Knockdown of STING or using STING inhibitor H-151 abolished the IFN-beta, TNF, and IL-6 induction by transfection of bacterial and host cyclic dinucleotides. cyclic dinucleotides 136-156 interleukin 6 Homo sapiens 83-87 34862831-9 2022 EEP + DTX exerted no cytotoxic effects on monocytes and stimulated HLA-DR expression, TNF-alpha, and IL-6 production, exerted an immunorestorative action in the fungicidal activity, and reduced the oxidative stress. Ethyl 3-ethoxypropionate 0-3 interleukin 6 Homo sapiens 101-105 34981723-8 2021 Oil Red O staining intensified with incubation time extending beyond 2 h. IL-6 production and lipid accumulation in L02 hepatocytes are influenced by sodium oleate in a dose- and time-dependent manner. oil red O 0-9 interleukin 6 Homo sapiens 74-78 34107329-15 2021 The activated IL-4 and IL-6 production was also suppressed actively at 25 mug/ml of taraxerone. taraxerone 84-94 interleukin 6 Homo sapiens 23-27 34107329-19 2021 In PMA stimulated THP-1 Macrophage Cell Lines, taraxerone was capable of suppressing the cell number and IL-6. taraxerone 47-57 interleukin 6 Homo sapiens 105-109 28163961-7 2017 RESULTS: After 60 days, both types of boron significantly improve the clinical scores, in association with significant decrease in the serum levels of ESR, hsCRP, IL-1alpha, IL-6, and TNF-alpha with remarkable superiority for calcium fructoborate (CFB) over sodium tetraborate (NTB), compared to baseline and placebo-treated group. Boron 38-43 interleukin 6 Homo sapiens 174-178 34638448-5 2021 Increasing levels of IL6, IL8, CXCL16, MPIF1, and YKL40 correlated with increasing levels of ceramide in both cohorts. Ceramides 93-101 interleukin 6 Homo sapiens 21-24 34916261-7 2021 RESULTS: Patients with atopic asthma had increased induction of IL-4, IFN-beta, IL-6, TNF-alpha, and IL-1beta after poly (I:C) stimulation compared to non-atopic patients, whereas in patients with eosinophilic asthma only IL-6 and IL-8 induction was higher than in non-eosinophilic asthma. Poly I-C 116-126 interleukin 6 Homo sapiens 80-84 27871564-7 2016 The groups were comparable regarding to POCD incidence; however, IL-6 levels were lower the seventh day after surgery for remifentanil group (P= .04). Remifentanil 122-134 interleukin 6 Homo sapiens 65-69 34950134-8 2021 Imiquimod also reduced poly(I:C)-induced pro-inflammatory cytokines including IL-1beta, IL-6, IL-8, and IL-33. Imiquimod 0-9 interleukin 6 Homo sapiens 88-92 34950134-8 2021 Imiquimod also reduced poly(I:C)-induced pro-inflammatory cytokines including IL-1beta, IL-6, IL-8, and IL-33. Poly I-C 23-32 interleukin 6 Homo sapiens 88-92 34539640-10 2021 Conclusion: Our findings showed that the overactive IL6 signal pathway led to autoimmune arthritis, especially in RA and AS. Arsenic 121-123 interleukin 6 Homo sapiens 52-55 27745952-3 2016 Alum-adjuvanted vaccines induce local inflammatory nodules at injection sites, and the systemic and local production of the inflammatory cytokines, IL-1beta, IL-6, and TNF-alpha, has been reported to occur three hours after vaccinations. aluminum sulfate 0-4 interleukin 6 Homo sapiens 158-162 34837768-9 2021 VK2 supplementation lowered the expression of tumour necrosis factor-alpha and interleukin-6 compared to that in the PA group. Palmitic Acid 117-119 interleukin 6 Homo sapiens 79-92 34643021-4 2021 Moreover, we demonstrated, for the first time in human adipocytes, that cells exposure to PA induced gene expression of proinflammatory cytokines TNF-alpha, IL-6, IL-8, and MCP-1. Palmitic Acid 90-92 interleukin 6 Homo sapiens 157-161 27207502-12 2016 When the biopsies were incubated with 1,25(OH)2D3, a decrease in IL-13 and IL-6 levels was registered. Calcitriol 38-49 interleukin 6 Homo sapiens 75-79 34453520-6 2021 Poly(I:C) dramatically induced the expression of the pro-inflammatory cytokines TNF-alpha and IL-6 in SC and LC through Toll-like receptor 3 and IFN-beta promoter stimulator 1 signaling pathways, impairing the integrity of the blood-testis barrier and testosterone synthesis. Poly I-C 0-9 interleukin 6 Homo sapiens 94-98 34385542-9 2021 PB-mediated inhibition of IL-17A also decreased the expression of IL-6, TNF-alpha, HIF-1alpha and VEGF in RA-FLSs. plumbagin 0-2 interleukin 6 Homo sapiens 66-70 27650973-5 2016 Furthermore, the production of IL-6 and phosphorylation of p38 in SSc fibroblasts was enhanced by adrenergic receptor (AR)beta agonist, isoproterenol, but not ARalpha agonist, oxymetazoline. Oxymetazoline 176-189 interleukin 6 Homo sapiens 31-35 34557270-6 2021 The effects of astaxanthin on the regulation of cyclooxygenase-2 (COX-2) pathways and the reduction and suppression of cytokines and other inflammatory agents such as IL-6 and TNF-alpha have already been identified. astaxanthine 15-26 interleukin 6 Homo sapiens 167-171 34643000-5 2021 CBD caused a parallel inhibition of interleukin 1 beta (IL-1beta), IL-6, tumor necrosis factor alpha (TNF-alpha), and IL-18 by enzyme-linked immunosorbent assay (ELISA) assay. Cannabidiol 0-3 interleukin 6 Homo sapiens 67-71 27604412-6 2016 The ensuing Ca(2+) entry then activates NFAT/calcineurin signaling to induce transcriptional production of the proinflammatory cytokines IL-6 and IL-8. nfat 40-44 interleukin 6 Homo sapiens 137-141 34740670-0 2021 Cannabidiol selectively modulates interleukin (IL)-1beta and IL-6 production in toll-like receptor activated human peripheral blood monocytes. Cannabidiol 0-11 interleukin 6 Homo sapiens 61-65 34229236-8 2021 Present article highlights new mechanistic insights through which DMB inhibits ROS/RNS, oxidative stress, mitochondrial dysfunctions and neuroinflammation such as NFkappaB, TNF-alpha, IL-6 and IL-8, cytokinin. demethyleneberberine 66-69 interleukin 6 Homo sapiens 184-188 34332517-8 2021 Dose-effect relationship meta-analysis results showed that arsenic exposure significantly increased the expression level of IL-6. Arsenic 59-66 interleukin 6 Homo sapiens 124-128 34740670-8 2021 Additionally, CBD treatment induced significant modulation of IL-6 production by monocytes activated through most TLRs, except for TLRs 1 and 3. Cannabidiol 14-17 interleukin 6 Homo sapiens 62-66 26547220-5 2016 Pro-inflammatory cytokine IL-1beta, IL-6, and TNF-alpha expressions were significantly higher in the AGA group than in the NAGA or HC group (P < 0.05, respectively). aga 101-104 interleukin 6 Homo sapiens 36-40 34893116-15 2021 The levels of IL-6, IL-10 and TGF-beta in supernatant decreased significantly after GJ inhibitor 18alpha-GA was added. Gallium 105-107 interleukin 6 Homo sapiens 14-18 34877356-12 2021 The decreased degree of IL-6 and TNF-alpha in CTG was higher than that in RTG (p < 0.05). ctg 46-49 interleukin 6 Homo sapiens 24-28 34332517-11 2021 CONCLUSIONS: Exposure to low dose of arsenic could promote the expression of JAK2/STAT3 and induce the malignant proliferation of cells through upregulating IL-6, and there was dose-effect relationship among them. Arsenic 37-44 interleukin 6 Homo sapiens 157-161 27397088-3 2016 RESULTS: When combined, calcitriol and interferon-beta appeared to potentiate the effects of one another on reducing IL-6. Calcitriol 24-34 interleukin 6 Homo sapiens 117-121 34356659-9 2021 The renin-angiotensin (RA) system affects the inflammatory process by increasing the IL-6 level. Radium 23-25 interleukin 6 Homo sapiens 85-89 34253436-9 2022 RESULTS: Pg-LPS or poly I:C significantly enhanced the production of IL-6 and PGE2 in MG63 cells. Poly I-C 19-27 interleukin 6 Homo sapiens 69-73 34867348-7 2021 We showed that LPS-induced expression of IL-6 and IL-1beta was cAMP dependent, that IL-6 and IL-1beta expression were induced by direct cAMP activation (forskolin) and that RG0216 and deprenyl effectively reduced cAMP-mediated cytokine expression. Selegiline 184-192 interleukin 6 Homo sapiens 41-45 34889899-10 2021 The MDT confirmed that two key activators (beta-Amyrone, beta-Stigmasterol) bound most stably to PPARA, PPARD, PPARG, FABP3, FABP4, and NR1H3 on the PPAR signaling pathway, also, three key inhibitors (Neotocopherol, Xanthosine, and beta-Amyrone) bound most tightly to AKT1, IL6, FGF2, and PHLPP1 on the PI3K-Akt signaling pathway. beta-amyrenone 43-55 interleukin 6 Homo sapiens 274-277 34889899-10 2021 The MDT confirmed that two key activators (beta-Amyrone, beta-Stigmasterol) bound most stably to PPARA, PPARD, PPARG, FABP3, FABP4, and NR1H3 on the PPAR signaling pathway, also, three key inhibitors (Neotocopherol, Xanthosine, and beta-Amyrone) bound most tightly to AKT1, IL6, FGF2, and PHLPP1 on the PI3K-Akt signaling pathway. Stigmasterol 57-74 interleukin 6 Homo sapiens 274-277 34836187-6 2021 As a secondary endpoint, we assessed the correlation between serum 25(OH)D3 levels and pro-inflammatory cytokine interleukin-6 (IL-6) in patients with extremely low serum 25(OH)D3 levels (<1 ng/mL) and in a subset supplemented with 1alpha,25(OH)2D3. Calcifediol 67-75 interleukin 6 Homo sapiens 113-126 34836187-6 2021 As a secondary endpoint, we assessed the correlation between serum 25(OH)D3 levels and pro-inflammatory cytokine interleukin-6 (IL-6) in patients with extremely low serum 25(OH)D3 levels (<1 ng/mL) and in a subset supplemented with 1alpha,25(OH)2D3. Calcifediol 67-75 interleukin 6 Homo sapiens 128-132 34277696-11 2021 Compared with the propofol group, BAL levels of IL-6 in the dependent ventilated lung were decreased in the sevoflurane group (three trials, 256 participants; standardized mean difference (SMD), -0.51; 95% confidence interval (CI), -0.90 to -0.11; p = 0.01; I 2 = 46%). Propofol 18-26 interleukin 6 Homo sapiens 48-52 27397088-4 2016 Calcitriol significantly reduced the production of IL-2, IL-4, IL-6, and IFN-gamma, while interferon-beta significantly reduced production of IL-6 and TNF-alpha, and increased IL-10. Calcitriol 0-10 interleukin 6 Homo sapiens 63-67 27057737-7 2016 Stimulation with R-848 resulted in significant higher secretion of TNFalpha, IL-6, IL-10, IL-12/IL-23p40, IL-12p70, and IFN-gamma. resiquimod 17-22 interleukin 6 Homo sapiens 77-81 34193056-7 2021 The primary endpoint is the effect of empagliflozin on changes of plasma interleukin 6 (IL-6) after 26 weeks of treatment. empagliflozin 38-51 interleukin 6 Homo sapiens 73-86 34193056-7 2021 The primary endpoint is the effect of empagliflozin on changes of plasma interleukin 6 (IL-6) after 26 weeks of treatment. empagliflozin 38-51 interleukin 6 Homo sapiens 88-92 34844720-0 2021 The anti-neoplastic activities of aloperine in HeLa cervical cancer cells are associated with inhibition of the IL-6-JAK1-STAT3 feedback loop. aloperine 34-43 interleukin 6 Homo sapiens 112-116 34844720-12 2021 For molecular mechanisms, the expression and activation of the IL-6-JAK1-STAT3 feedback loop were markedly suppressed by ALO treatment. aloperine 121-124 interleukin 6 Homo sapiens 63-67 34707507-7 2021 The inhibitory effect of sIL-6R on IL-6-induced VSMC migration was assessed using cultured A7r5 VSMCs. sil-6r 25-31 interleukin 6 Homo sapiens 35-39 27219277-8 2016 Treatment with 20 muM PBDE also increased the expression and secretion of the proinflammatory factor, IL-6, into the KGN cell culture medium. 20 mum pbde 15-26 interleukin 6 Homo sapiens 102-106 34707507-13 2021 IL-6 could be responsible for aorta dilation because IL-6 stimulated VSMC migration in vitro, an effect that is inhibited by sIL-6R. sil-6r 125-131 interleukin 6 Homo sapiens 0-4 34707507-13 2021 IL-6 could be responsible for aorta dilation because IL-6 stimulated VSMC migration in vitro, an effect that is inhibited by sIL-6R. sil-6r 125-131 interleukin 6 Homo sapiens 53-57 34707507-17 2021 Because sIL-6R inhibits IL-6-induced VSMC migration, a possible mechanism to regulate IL-6-dependent VSMC migration is also proposed. sil-6r 8-14 interleukin 6 Homo sapiens 24-28 34707507-17 2021 Because sIL-6R inhibits IL-6-induced VSMC migration, a possible mechanism to regulate IL-6-dependent VSMC migration is also proposed. sil-6r 8-14 interleukin 6 Homo sapiens 86-90 34203170-3 2021 We observed the secretion of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, and IL-8 by treating FLA-AA to human dermal fibroblasts, as well as macrophages. fla-aa 142-148 interleukin 6 Homo sapiens 101-119 34103066-10 2021 RESULTS: Taurine significantly decreased the serum levels of IL-6 (p = 0.04) and marginally APACHEII score (p = 0.05). Taurine 9-16 interleukin 6 Homo sapiens 61-65 29371911-2 2017 Our previous findings in pancreatic cancer and melanoma suggest that inhibition of these pathways by a TLR3 signaling inhibitor, phenylmethimazole (C10), results in significantly decreased IL-6 levels, STAT3 phosphorylation, minimal cancer cell migration and reduced cancer cell growth in vitro and in vivo. phenyl methimazole 129-146 interleukin 6 Homo sapiens 189-193 34103066-14 2021 CONCLUSION: According to the results of the present study, taurine supplementation can reduce the IL-6 levels as one of the important inflammatory markers in these patients; and enhances the clinical outcomes too. Taurine 59-66 interleukin 6 Homo sapiens 98-102 34075143-12 2021 Additionally, Sulodexide decreases the secretion of IL6 and VEGF-A from senescent HREC and increases their TEER. glucuronyl glucosamine glycan sulfate 14-24 interleukin 6 Homo sapiens 52-55 34680530-8 2021 Remarkably, certain bDMARDs were as efficient as JAKi in suppressing the IL-6 and MMP3 secretion of SF stimulated by Th (adalimumab, secukinumab) or B cells (canakinumab) and combining bDMARDs with JAKi had synergistic effects. Thorium 117-119 interleukin 6 Homo sapiens 73-77 34332276-7 2021 In addition, SP significantly increased TNF-alpha, IL-1beta, IL-6, ICAM-1, VCAM-1, P-selectin, and E-selectin levels (P < 0.01), decreased IL-10 levels (P < 0.01), and increased the adhesion rates of monocytes and neutrophils (P < 0.01). Palmitic Acid 13-15 interleukin 6 Homo sapiens 61-65 27117458-7 2016 In a clinically-relevant model of acute inflammatory response in IL-6-stimulated human hepatocytes, STAT3 silencing induced by HAS-Ca(2+)-siRNA NPs resulted in marked decrease in the total and activated STAT3 protein levels, as well as in the expression levels of downstream acute phase response genes. hexadehydroastechrome 127-130 interleukin 6 Homo sapiens 65-69 34573091-4 2021 We found that diHEP-DPA significantly reduced lipopolysaccharide (LPS)-induced inflammatory cytokines secretion of THP1 macrophages, IL-6, and TNF-alpha. dihep-dpa 14-23 interleukin 6 Homo sapiens 133-137 34072916-5 2021 However, auranofin significantly inhibited the levels of NO, monocyte chemoattractant protein-1, and pro-inflammatory cytokines, such as interleukin (IL)-1beta, tumor necrosis factor-alpha, and IL-6, which had been increased by co-treatment with PA and LPS. Palmitic Acid 246-248 interleukin 6 Homo sapiens 194-198 34072916-6 2021 Moreover, the expression of inducible NO synthase, IL-1beta, and IL-6 mRNA and protein levels increased by PA and LPS were reduced by auranofin. Palmitic Acid 107-109 interleukin 6 Homo sapiens 65-69 35504209-2 2022 In this study, a series of benzobis(imidazole) derivatives were identified as STAT3 signal inhibitors, among which compound 24 showed significant inhibition of IL-6 induced JAK/STAT3 signalling pathway activation. benzobis 27-35 interleukin 6 Homo sapiens 160-164 34573091-6 2021 During the polarization process, diHEP-DPA treatment decreased the concentration of TGF-beta1, IL-1beta, IL-6, and TNF-alpha in culture supernatants via inhibiting the NF-kappaB pathway. dihep-dpa 33-42 interleukin 6 Homo sapiens 105-109 27129274-5 2016 It effectively competes for binding to the cytokine with IL-6 receptor (IL-6R) by using side chains of two CDR residues filling the site I cavities of IL-6, thus mimicking the interactions of Phe(229) and Phe(279) of IL-6R. Phenylalanine 192-195 interleukin 6 Homo sapiens 57-61 34474820-7 2021 This PTV-loaded nanocarrier triggers apoptosis by reducing the mRNA level of anti-apoptotic genes NF-kbeta, IL-6, BIRC1 and BIRC5 by 89%, 33%, 81% and 63%, respectively, and the cell viability by >60%. pitavastatin 5-8 interleukin 6 Homo sapiens 108-112 34259987-0 2021 Activation of autophagy reverses gemcitabine-induced immune inhibition of RAW264.7 macrophages by promoting TNF-alpha, IL-6 and MHC-II expression. gemcitabine 33-44 interleukin 6 Homo sapiens 119-123 35367240-10 2022 JAK inhibitors, namely Tofacitinib, Baricitinib, Decernotinib, Upadacitinib, Peficitinib, and Filgotinib, have demonstrated clinical efficacy in recent decades as an alternative therapeutic strategy to abrogate IL-6 mediated aberrant activity in RA. GLPG0634 94-104 interleukin 6 Homo sapiens 211-215 35620570-3 2022 Results: The empagliflozin-metformin combination increased levels of the antioxidants (TAS, SOD, and GPx up to 1.1-fold; P < 0.01), decreased the levels of prooxidants (AOPP and isoprostanes up to 1.2-fold, P < 0.01; AGE up to 1.5-fold, P < 0.01), and decreased inflammatory parameters (up to 1.5-fold, CRP P < 0.01; IL-6 P < 0.001). empagliflozin 13-26 interleukin 6 Homo sapiens 317-321 34259987-10 2021 GEM reduced immune effect of M1-type RAW264.7 macrophages via inhibiting TNF-alpha, IL-6 and MHC-II expression. gemcitabine 0-3 interleukin 6 Homo sapiens 84-88 27129274-5 2016 It effectively competes for binding to the cytokine with IL-6 receptor (IL-6R) by using side chains of two CDR residues filling the site I cavities of IL-6, thus mimicking the interactions of Phe(229) and Phe(279) of IL-6R. Phenylalanine 205-208 interleukin 6 Homo sapiens 57-61 34804428-15 2021 SB203580, PDTC, and alpha-LA reversed the effects of chemerin, reducing IL-6, TNF-alpha, NF-kappaB p-p65, and TGF-beta expression. SB 203580 0-8 interleukin 6 Homo sapiens 72-76 35134736-15 2022 IL-6, D-dimer, serum ferritin are more often elevated in CAROCM and might play a pathogenic role. carocm 57-63 interleukin 6 Homo sapiens 0-4 27267059-6 2016 In this review, we summarize the recent progress in understanding the roles and mechanisms of interleukin-6 in mediating pathological pain associated with bone cancer, peripheral nerve injury, spinal cord injury, chemotherapy-induced peripheral neuropathy, complete Freund"s adjuvant injection, and carrageenan injection. Carrageenan 299-310 interleukin 6 Homo sapiens 94-107 35218446-6 2022 MATERIALS AND METHODS: Proliferation, apoptosis, differentiation and Pro-inflammatory responses of RANKL-stimulated RAW254.7 macrophage treated with or without IL-6 were measured by MTT assay, quantitative PCR assay of the expression of apoptotic genes, osteoclast differentiation markers, and pro-inflammatory genes, respectively. monooxyethylene trimethylolpropane tristearate 182-185 interleukin 6 Homo sapiens 160-164 34318516-5 2022 IL-6:sIL-6R complex only slightly decreased relative to the no-intervention case. sil-6r 5-11 interleukin 6 Homo sapiens 0-4 34201564-2 2021 Recent studies have shown that adipokine extracellular nicotinamide phosphoribosyltransferase (eNAMPT or visfatin) induces the production of IL-6 and matrix metalloproteases (MMPs) in chondrocytes, suggesting it may promote articular cartilage degradation. Niacinamide 55-67 interleukin 6 Homo sapiens 141-145 26899309-3 2016 We first observed that tangeretin inhibited LPS-induced production of nitric oxide, tumor necrosis factor alpha, interleukin (IL)-6, and IL-1beta, as well as LPS-induced mRNA expression of inducible nitric oxide synthases and cytokines. tangeretin 23-33 interleukin 6 Homo sapiens 113-131 34140036-11 2021 Anti-miR-337-3p or ADAMTS5 overexpression correspondingly reversed si-circ-SPG11 or miR-337-3p overexpression-mediated facilitation in viability, and inhibition in apoptosis, TNF-alpha and IL-6 generation and ECM degradation in OA model cells. Silicon 67-69 interleukin 6 Homo sapiens 189-193 35563697-10 2022 Our multiplex ELISA data revealed that CBD and THC significantly diminished the levels of IL-6, IL-8, and tumor necrosis factor-alpha (TNF-alpha) after LPS treatment in THP-1 macrophages and HBECs. Cannabidiol 39-42 interleukin 6 Homo sapiens 90-94 26780754-7 2016 Consistent with our previous results, after 4 days, PEMF tended to reduce IL-1alpha-associated gene expression of IL-6 (25%, p=.07) in NP cells and MMP13 (26%, p=.10) in AF cells. pemf 52-56 interleukin 6 Homo sapiens 114-118 35219101-0 2022 Glycerophospholipid metabolism is involved in rheumatoid arthritis pathogenesis by regulating the IL-6/JAK signaling pathway. Glycerophospholipids 0-19 interleukin 6 Homo sapiens 98-102 35400331-8 2022 RESULTS: Excess sucrose significantly enhanced inflammatory signal molecules (e.g., IL-1beta, IL-6, CCL2) secretion, concomitant with the enhancement of intracellular triglycerides in co-cultured HepG2 cells. Sucrose 16-23 interleukin 6 Homo sapiens 94-98 34295778-4 2021 The effect of SOCS3 overexpression or knockdown on the proliferation and apoptosis of IL-6 treated human cytotrophoblasts were determined by Cell Counting Kit-8 (CCK8) assay and Annexin-V/Propidium Iodide (PI) double-staining assay, respectively. Propidium 188-204 interleukin 6 Homo sapiens 86-90 34151811-4 2021 METHODS: 200 and 400muM PA-conjugated BSA were applied to SH-SY5Y and HMC3 cells for 24 h. For FcgammaR blockage experiment, both cells were exposed to FcgammaR blocker before receiving of 200 and 400muM of PA-conjugated BSA for 24 h. RESULTS: PA significantly increased AD-related proteins, including Abeta and BACE1, as well as increasing TNFalpha, IL-1beta, and IL-6 in SH-SY5Y and HMC3 cells. Palmitic Acid 244-246 interleukin 6 Homo sapiens 365-369 26940199-8 2016 After 24 hrs CTLA4-Ig-DEX induced a significant decrease of gene expression (p<0.05) for TNF-alpha and IL-6, whereas CTLA4-Ig-DEX-MTX induced a decrease (p<0.05) limited to IL-6, versus CNT. -ig-dex 18-25 interleukin 6 Homo sapiens 106-110 34560921-11 2021 Adverse biochemical events such as upregulation of CSF nitrite and nitrate, IL-6, TNF-a and p-Tau are also reduced significantly in oxiracetam treated CHI group. oxiracetam 132-142 interleukin 6 Homo sapiens 76-80 35363433-6 2022 In the arsenic-exposed group, the upregulation of METTL3 exacerbated the increase in cytokine levels (IL-6, IL-17, and IL-10), which was associated with the upregulation of keratins (Krt1 and Krt10). Arsenic 7-14 interleukin 6 Homo sapiens 102-106 26940199-8 2016 After 24 hrs CTLA4-Ig-DEX induced a significant decrease of gene expression (p<0.05) for TNF-alpha and IL-6, whereas CTLA4-Ig-DEX-MTX induced a decrease (p<0.05) limited to IL-6, versus CNT. -ig-dex 18-25 interleukin 6 Homo sapiens 179-183 26940199-9 2016 Finally, ICC showed, after 24 hrs of CTLA4-Ig-DEX or CTLA4-Ig-DEX-MTX treatment a reduction (p<0.05) of IL-1beta and IL-6 expression, versus CNT; DEX alone reduced only IL-1beta (p<0.05). dex-mtx 62-69 interleukin 6 Homo sapiens 120-124 35306042-11 2022 TFH decreased the levels of IL-1alpha, IL-1beta, IL-6, monocyte chemoattractant protein (MCP)-1, MCP-3, macrophage-derived chemokine (MDC), platelet-derived growth factor (PDGF)-BB, thymus and activation regulated chemokine (TARC) in the supernatants of the HaCaT cells treated by IFN-gamma/TNF-alpha. tfh 0-3 interleukin 6 Homo sapiens 49-53 26821279-10 2016 Triptolide also suppressed STAT3 activity and inhibited secretion of IL-6 in PEL cells. triptolide 0-10 interleukin 6 Homo sapiens 69-73 35483198-0 2022 Changes in plasma total saturated fatty acids and palmitic acid are related to pro-inflammatory molecule IL-6 concentrations after nutritional intervention for one year. Palmitic Acid 50-63 interleukin 6 Homo sapiens 105-109 35483198-6 2022 After one year of nutritional intervention, changes of plasma diet-derived total saturated FAs and palmitic acid were directly associated with changes in IL-6 (beta = 0.59 pg/mL (95% CI: 0.28, 0.89) per 1-SD, p-value = 0.001; beta = 0.64 pg/mL, 95% CI: 0.31, 0.98, p-value = 0.001), respectively, after correction for multiple testing. Palmitic Acid 99-112 interleukin 6 Homo sapiens 154-158 35483198-7 2022 Our findings suggest that saturated FAs of dietary origin, especially palmitic acid, are directly involved in the increase of IL-6 in plasma. Palmitic Acid 70-83 interleukin 6 Homo sapiens 126-130 35328817-12 2022 Our results demonstrate for the first time that shikonin derivatives have extensive effects on the inflammatory processes, MAPKs, and IL6/STAT3 downstream regulation in healthy and OA chondrocytes. shikonin 48-56 interleukin 6 Homo sapiens 134-137 35122928-3 2022 Cadmium chloride (CdCl2) caused cell viability loss, Reactive Oxygen Species (ROS) generation, glutathione reduction, and Interleukin-6 (IL-6) expression, accompanied by Nrf2 activation and Heme Oxygenase-1 (HO-1) expression. Cadmium Chloride 0-16 interleukin 6 Homo sapiens 137-141 35122928-3 2022 Cadmium chloride (CdCl2) caused cell viability loss, Reactive Oxygen Species (ROS) generation, glutathione reduction, and Interleukin-6 (IL-6) expression, accompanied by Nrf2 activation and Heme Oxygenase-1 (HO-1) expression. Cadmium Chloride 18-23 interleukin 6 Homo sapiens 137-141 26975648-5 2016 Furthermore, methylglyoxal induced carbonyl stress promotes the expression of the pro-inflammatory interleukins IL-6 and IL-8. Pyruvaldehyde 13-26 interleukin 6 Homo sapiens 112-116 35091230-7 2022 Furthermore, dezocine-matured DCs increased the general immune response by promoting the secretion of IL-12 and IL-6 cytokines and enhancing the proliferation and cytotoxicity of CD8+ T cells. dezocine 13-21 interleukin 6 Homo sapiens 112-116 35220126-11 2022 gamma-Al2O3-5-FU increased the level of MDA, while reducing the level of SOD and total-thiols as well as inflamatory markers (e.g., TNF-s and IL-6). gamma-al2o3-5-fu 0-16 interleukin 6 Homo sapiens 142-146 35580828-8 2022 TNF-alpha, IL-6 (pro-inflammatory) and IL-10 (anti-inflammatory) release quantification from a human monocyte cell line revealed a decrease in the pro-inflammatory cytokines concentrations in samples containing Ch(Gallate). ch(gallate 211-221 interleukin 6 Homo sapiens 11-15 26907260-4 2016 Our results demonstrate that preincubation with SP specifically inhibited CpG ODN- but not lipopolysaccharide (LPS)- and lipopeptide (PAM3CSK4)-stimulated TNF-alpha and IL-6 release. sp 48-50 interleukin 6 Homo sapiens 169-173 35551394-13 2022 In endometrial stromal cells of healthy women, IL-6/sIL-6R-induced STAT3 and SOCS1/3 expression at 1 h, whereas no STAT3 activation was detected at 48 h. Knockdown of STAT3 gene or S3I-201 (a STAT3 inhibitor) decreased the IL-6/sIL-6R-induced pro-fibrotic phenotype as well as NF-kappaB activation and TGF-beta1-induced cell proliferation of endometriotic stromal cells. sil-6r 228-234 interleukin 6 Homo sapiens 47-51 35228431-0 2022 A Case of TAFRO Syndrome that Responded to Prednisolone-only Treatment: Evaluating Changes in IL-6. Prednisolone 43-55 interleukin 6 Homo sapiens 94-98 35228431-4 2022 Improvement of symptoms after treatment with prednisolone was associated with interleukin-6 rather than C-reactive protein. Prednisolone 45-57 interleukin 6 Homo sapiens 78-91 26810262-1 2016 A series of oxazolidinone and indole derivatives were synthesized and evaluated as IL-6 signaling blockers by measuring the effects of these compounds on IL-6-induced luciferase expression in human hepatocarcinoma HepG2 cells transfected with p-STAT3-Luc. indole 30-36 interleukin 6 Homo sapiens 83-87 35269681-7 2022 Despite the paucity of in vivo studies, this comprehensive review suggests that O2O3 therapy might reduce serum levels of interleukin 6 in patients with TMD, low back pain, knee osteoarthritis and rheumatic diseases with a concrete and measurable interaction with the inflammatory pathway. o2o3 80-84 interleukin 6 Homo sapiens 122-135 35544792-7 2022 On Ox-LDL-stimulated HUVECs, KNL significantly inhibited the production of pro-inflammatory mediators such as NO, IL-1beta, iNOS, TNF-alpha and IL-6. kirenol 29-32 interleukin 6 Homo sapiens 144-148 35315502-4 2022 In the present study, the efficacy of co-targeting IL-6 and IL-8 in human ovarian cancer cells by bazedoxifene (Baze) + SCH527123 (SCH) treatment was examined. 2-hydroxy-N,N-dimethyl-3-(2-((1-(5-methylfuran-2-yl)propyl)amino)-3,4-dioxocyclobut-1-enylamino)benzamide 120-129 interleukin 6 Homo sapiens 51-55 26615574-0 2016 Farrerol inhibits IL-6 and IL-8 production in LPS-stimulated human gingival fibroblasts by suppressing PI3K/AKT/NF-kappaB signaling pathway. farrerol 0-8 interleukin 6 Homo sapiens 18-22 35315502-4 2022 In the present study, the efficacy of co-targeting IL-6 and IL-8 in human ovarian cancer cells by bazedoxifene (Baze) + SCH527123 (SCH) treatment was examined. 2-hydroxy-N,N-dimethyl-3-(2-((1-(5-methylfuran-2-yl)propyl)amino)-3,4-dioxocyclobut-1-enylamino)benzamide 131-134 interleukin 6 Homo sapiens 51-55 35229548-8 2022 RESULTS: The PoPEx treatment showed a significant reduction of inflammatory factors (IL-6, TNF-alpha, hsCRP), oxidative stress biomarkers (TBARS, NO2-, O2-) and homocysteine, while the TAC was increased. popex 13-18 interleukin 6 Homo sapiens 85-89 26615574-2 2016 In the present study, we investigated the anti-inflammatory effects of farrerol on the production of IL-6 and IL-8 in human gingival fibroblasts (HGFs) treated with lipopolysaccharide (LPS). farrerol 71-79 interleukin 6 Homo sapiens 101-105 25610950-5 2016 RESULTS: We found that BP IgG-induced IL-6 and IL-8 release from HaCaT cells was reduced in the presence of non-toxic doses of calcitriol. Calcitriol 127-137 interleukin 6 Homo sapiens 38-42 35038495-6 2022 The astaxanthin-loaded CCs could significantly inhibit the expression of inflammation factors such as interleukin-1beta, interleukin-6, tumor necrosis factor alpha, cyclooxygenase-2, myeloperoxidase, inducible nitric oxide synthase, and nitric oxide. astaxanthine 4-15 interleukin 6 Homo sapiens 121-134 35449861-14 2022 At 12 months after surgery, the serum IL-6 and TNF-alpha levels in the metoprolol group are lower than those in the control group (p < 0.05). Metoprolol 71-81 interleukin 6 Homo sapiens 38-42 35218740-0 2022 Carbon monoxide releasing molecule-2 attenuates angiotensin II-induced IL-6/Jak2/Stat3-associated inflammation by inhibiting NADPH oxidase- and mitochondria-derived ROS in human aortic smooth muscle cells. Carbon Monoxide 0-15 interleukin 6 Homo sapiens 71-75 26869439-6 2016 LPS-activated HKCCs, but not hepatocyte monocultures, treated with trovafloxacin or acetaminophen, compounds associated with immune-mediated hepatotoxicity, showed LPS-dependent decreases in interleukin-6 production with concomitant increases in Cyp3A activity. trovafloxacin 67-80 interleukin 6 Homo sapiens 191-204 35169867-6 2022 Of these three proteins, IL-6 was significantly downregulated by MFSCC treatment. mfscc 65-70 interleukin 6 Homo sapiens 25-29 35169867-7 2022 Western blot analysis revealed that IL-6 and its key downstream proteins JAK2 and STAT3 were suppressed in MFSCC-treated HaCaT cells. mfscc 107-112 interleukin 6 Homo sapiens 36-40 35048965-0 2022 Retraction: Cajanonic acid A regulates the ratio of Th17/Treg via inhibition of expression of IL-6 and TGF-beta in insulin-resistant HepG2 cells. cajanonic acid a 12-28 interleukin 6 Homo sapiens 94-98 26762881-5 2016 The addition of PS significantly reduced the expression of pro-inflammatory mediators, TNF-alpha, IL-1 beta, IL-6, MMP-2 and MMP-9 in HCECs exposed to hyperosmotic medium. pterostilbene 16-18 interleukin 6 Homo sapiens 109-113 35106376-5 2022 The versatility and throughput of the platform were demonstrated by screening two libraries of non-natural polyamide polymers with sizes of 1.77M and 1B compounds against the protein targets K-Ras, asialoglycoprotein receptor 1 (ASGPR), IL-6, IL-6 receptor (IL-6R), and TNFalpha. polyamide polymers 107-125 interleukin 6 Homo sapiens 237-241 35204104-6 2022 In addition, HC-EA, quercitrin, and hyperoside attenuated UVB-induced inflammatory mediators, including IL-6, IL-8, COX-2, and iNOS. quercitrin 20-30 interleukin 6 Homo sapiens 104-108 35093504-0 2022 High plasma IL-6 levels following haploidentical allogeneic hematopoietic stem cell transplantation post-transplant cyclophosphamide as predictor of early death with worse outcome. Cyclophosphamide 116-132 interleukin 6 Homo sapiens 12-16 25747515-11 2016 Microarray analysis showed that PPARalpha increased with decreased IL-6 and NF-kappaB within the hepatocytes after an MCDmp intervention. mcdmp 118-123 interleukin 6 Homo sapiens 67-71 35305556-7 2022 In patients taking vancomycin, miR-155-5p and miR-192-5p positively correlated with creatinine and NGAL values, and miR-192-5p and miR-423-5p positively correlated with procalcitonin and interleukin-6 in patients treated with a non-nephrotoxic antibiotic. mir-423-5p 131-141 interleukin 6 Homo sapiens 187-200 35310053-6 2022 RESULTS: Corneal fibroblasts exposed to polyI:C demonstrated decreased VCAM-1, ICAM-1, MCP-1, IL-6, and IL-8 expression levels upon exposure to LUT in a time-dependent and concentration-dependent manner. Poly I-C 40-47 interleukin 6 Homo sapiens 94-98 35359408-9 2022 The IL-6 PMR value of HCC patients in age (Spearman"s R=0.193, P=0.026) and TBIL (Spearman"s R=0.186, P=0.032) were very weak correlated. tbil 76-80 interleukin 6 Homo sapiens 4-8 27337797-5 2015 After treating the schizophrenics with the neuroleptic risperidone for 6 months, the serum levels of HMGB1, IL-1beta, TNF-alpha and IL-6 were decreased. Risperidone 55-66 interleukin 6 Homo sapiens 132-136 35247974-10 2022 Levels of the pro-inflammatory cytokine IL-6 in rectal mucosa after stimulation with TNF-alpha were attenuated after ingestion of Lp299. lp299 130-135 interleukin 6 Homo sapiens 40-44 26677330-9 2015 Baseline serum levels of interleukin-6 (Z=-2.155; P=0.031) and interleukin-8 (Z=-2.616; P=0.009) were significantly higher when moderate-to-severe AEs were present (n=13 patients with moderate-to-severe AEs). aes 147-150 interleukin 6 Homo sapiens 25-38 35215365-6 2022 At T1, the um-PEA-treated group presented a significant reduction in inflammation compared to the control group (CRP p = 0.007; IL-6 p = 0.0001; neutrophils to lymphocytes ratio p = 0.044). um-pea 11-17 interleukin 6 Homo sapiens 128-132 26156812-5 2015 Calcitriol inhibited interleukin (IL)-6, IL-8, CC chemokine ligand (CCL) 20, CXC chemokine ligand (CXCL) 10, and matrix metalloproteinase (MMP)-3 release from IL-1beta-stimulated HPDLC. Calcitriol 0-10 interleukin 6 Homo sapiens 21-39 35185568-10 2022 As a result, KFXYS significantly reversed the uterine inflammation indexes, including IL-1 and IL-6. kfxys 13-18 interleukin 6 Homo sapiens 95-99 26156812-7 2015 Moreover, we found c-jun N-terminal kinase (JNK) phosphorylation and IkappaB-alpha degradation in IL-1beta-stimulated HPDLC were inhibited by calcitriol, and JNK and nuclear factor (NF)-kappaB inhibitors could decrease IL-6, IL-8, CCL20, CXCL10, and MMP-3 productions in IL-1beta-treated HPDLC. Calcitriol 142-152 interleukin 6 Homo sapiens 219-223 35185578-5 2022 Empagliflozin also induces a decrease in the levels of the markers of inflammation IL-6, chemerin and chemerin receptor in the liver. empagliflozin 0-13 interleukin 6 Homo sapiens 83-87 26572585-4 2015 EC overexpression of mutant ITGB4 with specific tyrosines mutated to phenylalanine (Y1440, Y1526 Y1640, or Y1422) resulted in significantly attenuated CS-induced cytokine expression (IL6, IL-8, MCP-1, and RANTES). Phenylalanine 69-82 interleukin 6 Homo sapiens 183-186 34818666-4 2022 IVSK reduced the secretion of inflammatory mediators, interleukin (IL)-8 and monocyte chemoattractant protein-1 (MCP-1) and the mRNA expression of IL-6, IL-8, MCP-1 and IL-1beta. ivsk 0-4 interleukin 6 Homo sapiens 147-151 26447154-7 2015 Percentages of d6-alpha-tocopherol AUC0- t final in both the chylomicron (r = -0.46 to -0.52) and VLDL (r = -0.49 to -0.68) fractions were inversely correlated with oxidized LDL, IL-10, IL-6, and C-reactive protein. d6-alpha-tocopherol 15-34 interleukin 6 Homo sapiens 186-190 35163962-5 2022 Moreover, in vitro tests, in the presence of HFB-4 and HSF skin cells, confirmed a low cytotoxicity of the mineralized hybrid hydrogels, and also highlighted a significant increase in cell viability via MTT tests, preferentially, for the low concentration, crosslinked Alg/PVA/calcium phosphate hybrid materials (<1 mg/mL) in the presence of hydroxyapatite. monooxyethylene trimethylolpropane tristearate 203-206 interleukin 6 Homo sapiens 55-58 26500455-8 2015 Treatment with a combination of IL-6, LPS, TNF-alpha, IFN- gamma and IL-1beta induced the highest nitrite secretion (2.91 fold, P < 0.01) as compared to cells incubated in medium alone. Nitrites 98-105 interleukin 6 Homo sapiens 32-36 26320154-6 2015 Our results show that TNF-alpha and IL-6 treatment induced hyperreactivity and Ca(2+) hypersensitivity in response to pharmaco-mechanical stimuli, including 80 mM KCl, 1 muM phorbol 12-13-dibutyrate, and 30 nM U-46619. Potassium Chloride 163-166 interleukin 6 Homo sapiens 36-40 26320154-6 2015 Our results show that TNF-alpha and IL-6 treatment induced hyperreactivity and Ca(2+) hypersensitivity in response to pharmaco-mechanical stimuli, including 80 mM KCl, 1 muM phorbol 12-13-dibutyrate, and 30 nM U-46619. Phorbol 12,13-Dibutyrate 174-198 interleukin 6 Homo sapiens 36-40 26284488-9 2015 The search for mediators of senescent HPMC activity showed that increased SW480 cell proliferation was stimulated by IL-6, migration by CXCL8 and CCL2, invasion by IL-6, MMP-3 and uPA, and epithelial-mesenchymal transition by TGF-beta1. Hypromellose Derivatives 38-42 interleukin 6 Homo sapiens 117-121 26284488-9 2015 The search for mediators of senescent HPMC activity showed that increased SW480 cell proliferation was stimulated by IL-6, migration by CXCL8 and CCL2, invasion by IL-6, MMP-3 and uPA, and epithelial-mesenchymal transition by TGF-beta1. Hypromellose Derivatives 38-42 interleukin 6 Homo sapiens 164-168 25495336-10 2015 CONCLUSIONS: Vitamin D3 promotes osteogenic differentiation but also downregulates inflammation promoter-induced IL-6 cytokine and CXCL1 chemokine expression in human PDL cells, suggesting that vitamin D3 both stimulates bone regeneration and antagonizes inflammation in human periodontal tissue. Cholecalciferol 13-23 interleukin 6 Homo sapiens 113-117 25495336-10 2015 CONCLUSIONS: Vitamin D3 promotes osteogenic differentiation but also downregulates inflammation promoter-induced IL-6 cytokine and CXCL1 chemokine expression in human PDL cells, suggesting that vitamin D3 both stimulates bone regeneration and antagonizes inflammation in human periodontal tissue. Cholecalciferol 194-204 interleukin 6 Homo sapiens 113-117 26442273-0 2015 Post-Exercise Skeletal Muscle Glycogen Related to Plasma Cytokines and Muscle IL-6 Protein Content, but not Muscle Cytokine mRNA Expression. Glycogen 30-38 interleukin 6 Homo sapiens 78-82 26301727-0 2015 Total Synthesis of Prostaglandin 15d-PGJ(2) and Investigation of its Effect on the Secretion of IL-6 and IL-12. prostaglandin 15d-pgj 19-40 interleukin 6 Homo sapiens 96-100 26304941-10 2015 Colchicine administration significantly reduced transcoronary gradients of all 3 cytokines in ACS patients by 40% to 88% (P=0.028, 0.032, and 0.032, for IL-1beta, IL-18, and IL-6, respectively). Colchicine 0-10 interleukin 6 Homo sapiens 174-178 25749775-13 2015 Dexamethasone, calcitriol, anti-MD2/anti-TLR2 antibodies, and signalling inhibitors significantly reduced LPS+Der p2-induced IL-6/IL-8 secretion. Calcitriol 15-25 interleukin 6 Homo sapiens 125-129 26164743-3 2015 Thioacetamide injection significantly impaired hepatic synthetic, metabolic and excretory functions with significant increase in serum NO, IL-6 and IL-13 levels and negative shift in the oxidant/antioxidant balance. Thioacetamide 0-13 interleukin 6 Homo sapiens 139-143 26267685-12 2015 Alprostadil could ameliorate the inflammatory conditions of uremic dialysis patients by inhibition of the IL-6 expression. Alprostadil 0-11 interleukin 6 Homo sapiens 106-110 26083387-4 2015 Kdm5b-specific siRNA inhibition in BMDC led to a 10-fold increase in IFN-beta as well as increases in IL-6 and TNF-alpha compared to control-transfected cells. bmdc 35-39 interleukin 6 Homo sapiens 102-106 25058850-6 2015 MDP (an NLRC2 agonist), NAC and AZM, but not Tri-DAP (an NLRC1 agonist), increased IL-6 production in CF cells, indicating that in CF cells IL-6 upregulation is independent of NLRC1, but involves the activation of NLRC2. Acetylmuramyl-Alanyl-Isoglutamine 0-3 interleukin 6 Homo sapiens 83-87 25058850-6 2015 MDP (an NLRC2 agonist), NAC and AZM, but not Tri-DAP (an NLRC1 agonist), increased IL-6 production in CF cells, indicating that in CF cells IL-6 upregulation is independent of NLRC1, but involves the activation of NLRC2. Acetylmuramyl-Alanyl-Isoglutamine 0-3 interleukin 6 Homo sapiens 140-144 25058850-6 2015 MDP (an NLRC2 agonist), NAC and AZM, but not Tri-DAP (an NLRC1 agonist), increased IL-6 production in CF cells, indicating that in CF cells IL-6 upregulation is independent of NLRC1, but involves the activation of NLRC2. Azithromycin 32-35 interleukin 6 Homo sapiens 83-87 25058850-6 2015 MDP (an NLRC2 agonist), NAC and AZM, but not Tri-DAP (an NLRC1 agonist), increased IL-6 production in CF cells, indicating that in CF cells IL-6 upregulation is independent of NLRC1, but involves the activation of NLRC2. Azithromycin 32-35 interleukin 6 Homo sapiens 140-144 25611207-7 2015 A significant increment in IL-10 and a significant decrement in IL-6 (p<0.05) were also observed with prednisone both at rest and during exercise, without significant change in IL-1beta. Prednisone 105-115 interleukin 6 Homo sapiens 64-68 25661535-6 2015 Furthermore, gemigliptin reduced LPS-induced expression of adhesion molecules and inflammatory cytokines such as vascular cell adhesion molecule-1 (VCAM-1), E-selectin, tumor necrosis factor-alpha (TNF-alpha), monocyte chemoattractant protein-1 (MCP-1), interleukin-1beta (IL-1beta), and IL-6 in HUVECs. LC15-0444 13-24 interleukin 6 Homo sapiens 288-292 25721605-12 2015 Cytokine array analysis of conditioned media revealed higher levels of interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) in the CAA-conditioned medium. caa 146-149 interleukin 6 Homo sapiens 71-84 25721605-12 2015 Cytokine array analysis of conditioned media revealed higher levels of interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) in the CAA-conditioned medium. caa 146-149 interleukin 6 Homo sapiens 86-90 25890367-7 2015 The postoperative IL 6 levels were significantly higher in the CWC group in comparison with the AEC group at 6 hours, 24 hours, and 48 hours. CHEMBL3425950 63-66 interleukin 6 Homo sapiens 18-22 25675297-7 2015 Furthermore, nuclear factor-kappaB (NF-kappaB)/interleukin-6 (IL-6) activation was found to be responsible for PAK1-mediated stem-like phenotype following sunitinib treatment. Sunitinib 155-164 interleukin 6 Homo sapiens 62-66 25675297-8 2015 Both IL-6 neutralizing antibody and IPA3 administration enhanced tumor growth inhibition effect of sunitinib treatment on RCC cells in vitro and in vivo. Sunitinib 99-108 interleukin 6 Homo sapiens 5-9 25675297-9 2015 Our results unraveled that oncogenic activation of PAK1 defines an important mechanism for maintaining stem-like phenotype and sunitinib resistance through NF-kappaB/IL-6 activation in RCC, lending PAK1-mediated NF-kappaB/IL-6 activation considerable appeal as novel pharmacological therapeutic targets against sunitinib resistance. Sunitinib 127-136 interleukin 6 Homo sapiens 166-170 25675297-9 2015 Our results unraveled that oncogenic activation of PAK1 defines an important mechanism for maintaining stem-like phenotype and sunitinib resistance through NF-kappaB/IL-6 activation in RCC, lending PAK1-mediated NF-kappaB/IL-6 activation considerable appeal as novel pharmacological therapeutic targets against sunitinib resistance. Sunitinib 127-136 interleukin 6 Homo sapiens 222-226 25675297-9 2015 Our results unraveled that oncogenic activation of PAK1 defines an important mechanism for maintaining stem-like phenotype and sunitinib resistance through NF-kappaB/IL-6 activation in RCC, lending PAK1-mediated NF-kappaB/IL-6 activation considerable appeal as novel pharmacological therapeutic targets against sunitinib resistance. Sunitinib 311-320 interleukin 6 Homo sapiens 166-170 25675297-9 2015 Our results unraveled that oncogenic activation of PAK1 defines an important mechanism for maintaining stem-like phenotype and sunitinib resistance through NF-kappaB/IL-6 activation in RCC, lending PAK1-mediated NF-kappaB/IL-6 activation considerable appeal as novel pharmacological therapeutic targets against sunitinib resistance. Sunitinib 311-320 interleukin 6 Homo sapiens 222-226 25239226-6 2015 Induction of IL-6 production by IL-1beta was significantly reduced by addition of p38 MAPK (SB203580), MEK1/2 (U0126) or NF-kappaB (BAY11-7082) inhibitors, with the highest effect being observed with SB203580. U 0126 111-116 interleukin 6 Homo sapiens 13-17 24806275-5 2015 Exposure of the cells to LPS caused modest statistically insignificant increases in cytokine production; MnCl2 caused dose-related increases in production of all six cytokines (achieving statistical significance of p < 0.0171- < 0.0005 for IL-1beta, IL-6, IL-8, IFNgamma, and TNFalpha). manganese chloride 105-110 interleukin 6 Homo sapiens 256-260 24806275-6 2015 In the case of LPS and MnCl2 combinations, the observed increases in production of IL-1beta, IL-6, IL-8, IFNgamma, and G-CSF were greater than those seen with cells exposed to the individual agents. manganese chloride 23-28 interleukin 6 Homo sapiens 93-97 25234193-0 2015 Piperine inhibits IL-1beta-induced IL-6 expression by suppressing p38 MAPK and STAT3 activation in gastric cancer cells. piperine 0-8 interleukin 6 Homo sapiens 35-39 25234193-3 2015 However, the effects of piperine on IL-6 expression in gastric cancer cells have not yet been well defined. piperine 24-32 interleukin 6 Homo sapiens 36-40 25234193-5 2015 Our results showed that piperine inhibited interleukin-1beta (IL-1beta)-induced IL-6 expression in a dose-dependent manner. piperine 24-32 interleukin 6 Homo sapiens 80-84 25234193-6 2015 In addition, piperine also inhibited IL-6 promoter activity. piperine 13-21 interleukin 6 Homo sapiens 37-41 25234193-9 2015 Piperine inhibited IL-1beta-induced p38 MAPK and STAT3 activation and, in turn, blocked the IL-1beta-induced IL-6 expression. piperine 0-8 interleukin 6 Homo sapiens 109-113 25234193-11 2015 These results suggest that piperine may exert at least part of its anti-cancer effect by controlling IL-6 expression through the suppression of p38 MAPK and STAT3. piperine 27-35 interleukin 6 Homo sapiens 101-105 25281570-7 2014 The results demonstrated that, compared with controls, 24-h pretreatment with TNF-alpha, IL-6, or endothelin-1 increased reactivity and Ca(2+) sensitivity of HPAs as revealed by agonist challenges with 80 mM KCl, 1 muM serotonin (5-hydroxytryptamine), 30 nM U-46619, and 1 muM phorbol 12,13-dibutyrate. Potassium Chloride 208-211 interleukin 6 Homo sapiens 89-93 25463072-7 2014 RESULTS: In separate SMC and monocyte cultures (monocultures) 25-hydroxycholesterol only poorly activated IL-1, IL-6 and MCP-1 production, whereas LPS stimulated much higher cytokine levels than unstimulated cultures. 25-hydroxycholesterol 62-83 interleukin 6 Homo sapiens 112-116 25374755-12 2014 Activated BEAS-2B cells treated with lovastatin exhibited reduced IL-6, eotaxins (CCL11 and CCL24), and intercellular adhesion molecule-1 protein expression. Lovastatin 37-47 interleukin 6 Homo sapiens 66-70 25522414-6 2014 RESULTS: We found that venlafaxine and EPA were anti-inflammatory: venlafaxine decreased IL-6, with a trend for decreases of IL-8 and IP-10, while EPA decreased the levels of IL-6, IL-15, IL-1RA, and IP-10. Venlafaxine Hydrochloride 23-34 interleukin 6 Homo sapiens 89-93 25522414-6 2014 RESULTS: We found that venlafaxine and EPA were anti-inflammatory: venlafaxine decreased IL-6, with a trend for decreases of IL-8 and IP-10, while EPA decreased the levels of IL-6, IL-15, IL-1RA, and IP-10. Venlafaxine Hydrochloride 23-34 interleukin 6 Homo sapiens 175-179 25522414-6 2014 RESULTS: We found that venlafaxine and EPA were anti-inflammatory: venlafaxine decreased IL-6, with a trend for decreases of IL-8 and IP-10, while EPA decreased the levels of IL-6, IL-15, IL-1RA, and IP-10. Venlafaxine Hydrochloride 67-78 interleukin 6 Homo sapiens 89-93 25151086-0 2014 Synthetic (+)-terrein suppresses interleukin-6/soluble interleukin-6 receptor induced-secretion of vascular endothelial growth factor in human gingival fibroblasts. terrein 10-21 interleukin 6 Homo sapiens 33-46 25151086-4 2014 To our knowledge, this study is the first to report that synthetic (+)-terrein is not cytotoxic at concentrations less than 20 muM and suppresses IL-6/soluble IL-6 receptor (sIL-6R)-induced phosphorylation of signal transducer and activator of transcription-3, extracellular signal-regulated kinase 1/2, and c-jun N-terminal kinase 1/2-signaling proteins that are downstream of IL-6 signaling. terrein 67-78 interleukin 6 Homo sapiens 146-172 25151086-4 2014 To our knowledge, this study is the first to report that synthetic (+)-terrein is not cytotoxic at concentrations less than 20 muM and suppresses IL-6/soluble IL-6 receptor (sIL-6R)-induced phosphorylation of signal transducer and activator of transcription-3, extracellular signal-regulated kinase 1/2, and c-jun N-terminal kinase 1/2-signaling proteins that are downstream of IL-6 signaling. terrein 67-78 interleukin 6 Homo sapiens 146-150 25151086-5 2014 In addition, synthetic (+)-terrein suppresses IL-6/sIL-6R-induced vascular endothelial growth factor (VEGF) secretion in a concentration-dependent manner (p<0.01). terrein 23-34 interleukin 6 Homo sapiens 46-50 25151086-6 2014 These data suggest that synthetic (+)-terrein has potential anti-IL-6 signaling activity and suppresses VEGF-associated inflammatory disease progression. terrein 34-45 interleukin 6 Homo sapiens 65-69 25151996-6 2014 RESULTS: CAPE inhibited the expression of IL-6, MCP-1 and ICAM-1 induced by the pro-inflammatory cytokine IL-1beta in corneal fibroblasts. caffeic acid phenethyl ester 9-13 interleukin 6 Homo sapiens 42-46 25338584-5 2014 The level of VEGF and IL-6 in culture supernatants of RPMI8226/DOX was higher than that in RPMI 8226. rpmi 54-58 interleukin 6 Homo sapiens 22-26 25251539-7 2014 Finally, 9-S-HODE, 9-R-HODE, 13-R-HODE, or LPC inhibited the release of IL-6 from monocytes suggesting that these lipids may play important role in controlling inflammatory responses. 9-r-hode 19-27 interleukin 6 Homo sapiens 72-76 24947163-0 2014 Terpinen-4-ol and alpha-terpineol (tea tree oil components) inhibit the production of IL-1beta, IL-6 and IL-10 on human macrophages. alpha-terpineol 18-33 interleukin 6 Homo sapiens 96-100 24727346-7 2014 Results showed that animals receiving OR486 exhibited higher levels of NO derivatives, tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and chemokine (C-C motif) ligand 2 (CCL2) in a beta2- and beta3AR-dependent manner. OR486 38-43 interleukin 6 Homo sapiens 157-170 24727346-7 2014 Results showed that animals receiving OR486 exhibited higher levels of NO derivatives, tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and chemokine (C-C motif) ligand 2 (CCL2) in a beta2- and beta3AR-dependent manner. OR486 38-43 interleukin 6 Homo sapiens 172-176 24814708-6 2014 Biliverdin also reduced LPS-dependent expression of the pro-inflammatory cytokines TNF-alpha and IL-6. Biliverdine 0-10 interleukin 6 Homo sapiens 97-101 24913620-8 2014 RESULTS: We demonstrated that CB2 inverse agonists SR144528 and AM630, but not CB2 agonist HU308 or CB1 antagonist SR141716, effectively inhibited IL-6-induced secretion of soluble IgM without affecting cell proliferation as measured by thymidine uptake. iodopravadoline 64-69 interleukin 6 Homo sapiens 147-151 24576880-5 2014 RESULTS: The HSF, HCEC-12, ODM-2, and ARPE-19 express mRNA and protein for all vitamin D3 synthesizing and metabolizing components. Cholecalciferol 79-89 interleukin 6 Homo sapiens 13-16 24370115-1 2014 An Interleukin-6 (IL-6) electrochemical immunosensor was fabricated based on the Au nanoparticles (AuNP)-graphene-silica sol-gel as immobilization biointerface and AuNP-polydopamine (PDA)@carbon nanotubes (CNT) as the label of HRP-bound antibodies. aunp 99-103 interleukin 6 Homo sapiens 3-16 24370115-1 2014 An Interleukin-6 (IL-6) electrochemical immunosensor was fabricated based on the Au nanoparticles (AuNP)-graphene-silica sol-gel as immobilization biointerface and AuNP-polydopamine (PDA)@carbon nanotubes (CNT) as the label of HRP-bound antibodies. aunp 99-103 interleukin 6 Homo sapiens 18-22 24370115-2 2014 The AuNP-graphene-silica sol-gel film was prepared in situ and modified on the ITO electrode, providing a stable network for the immobilization of antibody and exhibiting a dynamic working range of 1-40 pg/mL with a low detection limit of 0.3 pg/mL IL-6 (at 3s). aunp 4-8 interleukin 6 Homo sapiens 249-253 24374976-9 2014 RESULTS: Compared with baseline values, LPS-matured mo-DC exhibited reduced expression of CD80 and reduced production of the cytokines IL-10, IL-1beta, and IL-6 following 26 weeks of oral vitamin D3 supplementation. Cholecalciferol 188-198 interleukin 6 Homo sapiens 156-160 24720919-9 2014 C-reactive protein and interleukin-6 were both significantly reduced in the colchicine group (-5.1 mg/l and -4.8 pg/ml, respectively; p < 0.001 for both, compared with the control group). Colchicine 76-86 interleukin 6 Homo sapiens 23-36 24308588-8 2014 Similarly, subjects with daily step count <= 5,203 and IL-6 > 2 pg/ml had an increased rate of AEs (RR, 2.04; 95% CI, 1.14-3.63) and COPD-related hospitalizations (RR, 4.27; 95% CI, 1.56-11.7) compared with subjects with daily step count > 5,203 and IL-6 <= 2 pg/ml. aes 101-104 interleukin 6 Homo sapiens 58-62 24308588-8 2014 Similarly, subjects with daily step count <= 5,203 and IL-6 > 2 pg/ml had an increased rate of AEs (RR, 2.04; 95% CI, 1.14-3.63) and COPD-related hospitalizations (RR, 4.27; 95% CI, 1.56-11.7) compared with subjects with daily step count > 5,203 and IL-6 <= 2 pg/ml. aes 101-104 interleukin 6 Homo sapiens 259-263 24901006-5 2014 CDM would reactivate HIV from latency by modulating the release of IL-6 and TNF- alpha , since the amount of both cytokines measured through ELISA significantly increased in U1 treated cells. 1-cinnamoyl-3,11-dihydroxymeliacarpin 0-3 interleukin 6 Homo sapiens 67-71 24095958-3 2013 Herein, we identify the naturally occurring sesquiterpene lactone cynaropicrin as a potent inhibitor of both IL-6-inducible and constitutive STAT3 activation (IC50=12 muM). sesquiterpene lactone 44-65 interleukin 6 Homo sapiens 109-113 23263548-11 2013 Treatment with fenofibrate resulted in significant decrease in CRP and IL-6 concentrations and improvement in lipid profile. Fenofibrate 15-26 interleukin 6 Homo sapiens 71-75 24001805-8 2013 Furthermore, potassium channel blockers tetraethylammonium (TEA), 4-amino pyridine (4-AP), and margatoxin (MGTX) reduced the nano-SiO2-induced cytotoxity and inflammation, i.e., increase in the cell survival rate, and decrease in the LDH leakage and production of TNF-alpha and IL-6. Tetraethylammonium 40-58 interleukin 6 Homo sapiens 278-282 24001805-8 2013 Furthermore, potassium channel blockers tetraethylammonium (TEA), 4-amino pyridine (4-AP), and margatoxin (MGTX) reduced the nano-SiO2-induced cytotoxity and inflammation, i.e., increase in the cell survival rate, and decrease in the LDH leakage and production of TNF-alpha and IL-6. Tetraethylammonium 60-63 interleukin 6 Homo sapiens 278-282 24001805-8 2013 Furthermore, potassium channel blockers tetraethylammonium (TEA), 4-amino pyridine (4-AP), and margatoxin (MGTX) reduced the nano-SiO2-induced cytotoxity and inflammation, i.e., increase in the cell survival rate, and decrease in the LDH leakage and production of TNF-alpha and IL-6. 4-Aminopyridine 66-82 interleukin 6 Homo sapiens 278-282 24001805-8 2013 Furthermore, potassium channel blockers tetraethylammonium (TEA), 4-amino pyridine (4-AP), and margatoxin (MGTX) reduced the nano-SiO2-induced cytotoxity and inflammation, i.e., increase in the cell survival rate, and decrease in the LDH leakage and production of TNF-alpha and IL-6. 4-Aminopyridine 84-88 interleukin 6 Homo sapiens 278-282 24043889-5 2013 Accordingly, the Galphai inhibitor pertussis toxin and MEK inhibitor U0126 blocked C5a inhibition of LPS-induced IL-6 and TNF production from macrophages. U 0126 69-74 interleukin 6 Homo sapiens 113-117 24143215-7 2013 Moreover, inhibition of miR-329 prevents PDG-induced inhibition of NF-kappaB p65 and IL-6 mRNA expression, and restores cell survival. mir-329 24-31 interleukin 6 Homo sapiens 85-89 24073294-11 2013 In vivo, U0126 significantly increased cell apoptosis and decreased cell proliferation in the intestine, increased intestinal permeability, intestinal and lung neutrophil infiltration, and injury, as well as systemic pro-inflammatory cytokines, TNF-alpha, IL-6 and IL-1beta. U 0126 9-14 interleukin 6 Homo sapiens 256-260 23136947-6 2013 Similarly, IL-6 upregulation was partially prevented by siMyD88 or siTRAM in HGF stimulated with Pg LPS, as well as in both fibroblast subtypes challenged with Pam2CSK4. sitram 67-73 interleukin 6 Homo sapiens 11-15 23538947-8 2013 IL-6 secretion was completely inhibited via inhibitor of transcription (Actinomycin D) or protein synthesis (Cycloheximide) confirming that IL-6 releases constitutively from BeWo cells. Cycloheximide 109-122 interleukin 6 Homo sapiens 0-4 23538947-8 2013 IL-6 secretion was completely inhibited via inhibitor of transcription (Actinomycin D) or protein synthesis (Cycloheximide) confirming that IL-6 releases constitutively from BeWo cells. Cycloheximide 109-122 interleukin 6 Homo sapiens 140-144 23603753-8 2013 Rebamipide also suppressed TNFalpha-induced expression of interleukin-6 and interleukin-8 at the mRNA and protein levels and inhibited the TNFalpha-induced degradation of IkappaBalpha. rebamipide 0-10 interleukin 6 Homo sapiens 58-71 23246638-8 2013 Moreover the antipsychotics, haloperidol and risperidone, were able to inhibit the secretion of S100B following IL-6 stimulation in C6 glioma cells. Risperidone 45-56 interleukin 6 Homo sapiens 112-116 23336844-6 2013 PCR products were submitted to restriction endonuclease digestion and analysed by polyacrylamide gel electrophoresis to distinguish allele G and C of the IL-6 gene, allowing the detection of the polymorphism and determination of genotypes. polyacrylamide 82-96 interleukin 6 Homo sapiens 154-158 23862224-1 2013 OBJECTIVE: To observe the changes in the expressions of STAT3 and NF-KB in PC-3 cells after IL-6 stimulation and to verify the effects of the NF-KB inhibitor caffeic acid phenethyl ester (CAPE) on the expressions of p-STAT3 and IL-6 in the PC-3 prostate cancer cell line. caffeic acid phenethyl ester 158-186 interleukin 6 Homo sapiens 228-232 23862224-6 2013 TNF-alpha + CAPE induced statistically lower expressions of IL-6 and p-STAT3 than TNF-alpha alone (P < 0.05). caffeic acid phenethyl ester 12-16 interleukin 6 Homo sapiens 60-64 23862224-7 2013 CONCLUSION: CAPE can inhibit IL-6 secretion induced by TNF-alpha in PC-3 cells and thus suppress STAT3 translocation. caffeic acid phenethyl ester 12-16 interleukin 6 Homo sapiens 29-33 23748365-8 2013 In addition, the sRAGE levels were increased, whereas those of IL-6 were decreased after calcitriol treatment. Calcitriol 89-99 interleukin 6 Homo sapiens 63-67 23626759-9 2013 Furthermore, afzelin showed inhibitory effects on UVB-induced release of pro-inflammatory mediators such as interleukin-6, tumor necrosis factor-alpha, and prostaglandin-E2 in human keratinocytes by interfering with the p38 kinase pathway. afzelin 13-20 interleukin 6 Homo sapiens 108-150 23488631-5 2013 A significant, more than 50% mean inhibition of PMA/I-induced IL-6 and IL-8 release was demonstrated for the volatile compounds 1,8-cineole, borneol, camphor, and thujone, but not for the nonvolatile rosmarinic acid when applied in concentrations representative of sage infusion. Camphor 150-157 interleukin 6 Homo sapiens 62-66 22508334-10 2013 Pretreatment with 1,25(OH)2D3 (10 nM and 100 nM) significantly decreased the stimulatory effects of MC medium, TNFalpha and IL-1beta on MCP-1 expression and protein release, although the effect on stimulated release of IL-6 was less potent. Calcitriol 18-29 interleukin 6 Homo sapiens 219-223 22508334-10 2013 Pretreatment with 1,25(OH)2D3 (10 nM and 100 nM) significantly decreased the stimulatory effects of MC medium, TNFalpha and IL-1beta on MCP-1 expression and protein release, although the effect on stimulated release of IL-6 was less potent. mc medium 100-109 interleukin 6 Homo sapiens 219-223 23039030-9 2013 In conclusion, in antiretroviral-naive subjects treated with abacavir-based therapy for 144 weeks, median inflammatory biomarker levels for hsCRP and IL-6 generally remained stable with no significant difference between baseline and week 144 for subjects with either FRS <6% or FRS >=6%. abacavir 61-69 interleukin 6 Homo sapiens 140-154 24070175-9 2013 We found that transplantation of hUCMSCs encapsulated in GL scaffolds had a significant impact on the prevention of glial scar formation (low glial acidic fibrillary protein) and in the reduction of neuroinflammation (low interleukin-6 and the microglial markers ED1 and Iba1) in the recipient tissue. gl 57-59 interleukin 6 Homo sapiens 222-235 23710204-6 2013 Vitamin D3 acted in synergy with the TLR agonists LPS and peptidoglycan (PGN) in inducing IL-6, IL-8, and IL-10, whereas vitamin D3 completely inhibited LPS-induced secretion of IL-12. Cholecalciferol 0-10 interleukin 6 Homo sapiens 90-94 23103122-0 2013 Calcitriol downregulates TNF-alpha and IL-6 expression in cultured placental cells from preeclamptic women. Calcitriol 0-10 interleukin 6 Homo sapiens 39-43 23103122-5 2013 Therefore, the aim of the present study was to investigate calcitriol effects upon TNF-alpha, IFN-gamma, IL-6 and IL-1beta in cultured placental cells from preeclamptic women by using qPCR and ELISA. Calcitriol 59-69 interleukin 6 Homo sapiens 105-109 23103122-7 2013 In these cell cultures, pro-inflammatory cytokines TNF-alpha and IL-6 secretion and mRNA expression were downregulated by calcitriol (P<0.05). Calcitriol 122-132 interleukin 6 Homo sapiens 65-69 22925537-0 2012 Effects of a 1-year supplementation with cholecalciferol on interleukin-6, tumor necrosis factor-alpha and insulin resistance in overweight and obese subjects. Cholecalciferol 41-56 interleukin 6 Homo sapiens 60-73 22939972-1 2012 Previously we reported that the sesquiterpene lactone parthenolide induces oxidative stress in cardiac myocytes, which blocks Janus kinase (JAK) activation by the interleukin 6 (IL-6)-type cytokines. sesquiterpene lactone 32-53 interleukin 6 Homo sapiens 163-176 22939972-1 2012 Previously we reported that the sesquiterpene lactone parthenolide induces oxidative stress in cardiac myocytes, which blocks Janus kinase (JAK) activation by the interleukin 6 (IL-6)-type cytokines. sesquiterpene lactone 32-53 interleukin 6 Homo sapiens 178-182 22362117-3 2012 Interleukin (IL)-6 has been suggested to play a role in controlling EVT invasion. EVT 68-71 interleukin 6 Homo sapiens 0-18 22362117-4 2012 We hypothesized that IL-6 produced by cells in uterine decidua would regulate EVT invasiveness via IL-6Ralpha and gp130 receptors expressed by trophoblast cells. EVT 78-81 interleukin 6 Homo sapiens 21-25 22362117-9 2012 IL-6 stimulated phosphorylation of several cell signalling proteins in EVT (8-14 weeks" gestation), although significance was lost after correction for multiple comparisons. EVT 71-74 interleukin 6 Homo sapiens 0-4 22362117-10 2012 Incubation with IL-6 decreased secretion of regulated upon activation, normal T-cell expressed and secreted (RANTES) by EVT cells. EVT 120-123 interleukin 6 Homo sapiens 16-20 22362117-11 2012 In conclusion, although IL-6 did not affect trophoblast cell invasion, it stimulated EVT cellular cascades and inhibited secretion of RANTES involved in a number of cellular processes. EVT 85-88 interleukin 6 Homo sapiens 24-28 22213519-4 2012 RESULTS: Before ADT, serum interleukin-6 levels were inversely correlated with serum total-testosterone (rs = -0.305, P = 0.009) and dihydrotestosterone (rs = -0.380, P = 0.006) concentrations, but not correlated with adrenal androgen or estradiol levels. Dihydrotestosterone 133-152 interleukin 6 Homo sapiens 27-40 22564837-9 2012 The release of TNF-alpha, IL-6, and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) by circulating monocytes after stimulation was greater in the clarithromycin group than in the placebo group. Clarithromycin 165-179 interleukin 6 Homo sapiens 26-30 22425623-10 2012 The ER accumulation of Z-AT was shown to induce PERK-dependent NF-kappaB, IL-6, IL-8, and RGS16 and calnexin; all of which could be abrogated effectively by 4M. z-at 23-27 interleukin 6 Homo sapiens 74-78 22649203-8 2012 Omniscan and gadodiamide signaling via TLRs 4 and 7 resulted in increased production and expression of numerous proinflammatory/profibrotic cytokines, chemokines, and growth factors, including CXCL10, CCL2, CCL8, CXCL12, IL-4, IL-6, TGF-beta, and vascular endothelial growth factor. gadodiamide 0-8 interleukin 6 Homo sapiens 227-231 22649203-8 2012 Omniscan and gadodiamide signaling via TLRs 4 and 7 resulted in increased production and expression of numerous proinflammatory/profibrotic cytokines, chemokines, and growth factors, including CXCL10, CCL2, CCL8, CXCL12, IL-4, IL-6, TGF-beta, and vascular endothelial growth factor. gadodiamide 13-24 interleukin 6 Homo sapiens 227-231 22761193-0 2012 Saliva components reestablish the basal production of IL-6 by mononuclear cells, 72 hours after nitinol archiwire placement: a preliminary study. nitinol 96-103 interleukin 6 Homo sapiens 54-58 22426431-7 2012 There were significant differences in pregnancy-specific distress, IL-6, and TNF-alpha between women who delivered prematurely versus those who delivered at term, and elevated levels of pregnancy-specific distress, IL-6, and TNF-alpha were predictive of shortened GAB overall. gab 264-267 interleukin 6 Homo sapiens 215-219 22218461-9 2012 Tri-DAP and MDP led to the production of IL-6 and IL-8 and the activation of NF-kappaB and MAPK in PDL cells. Acetylmuramyl-Alanyl-Isoglutamine 24-27 interleukin 6 Homo sapiens 53-57 21848430-8 2012 We observed inhibition of cytokines (interleukin [IL]-1beta (beta), IL-6, IL-8, IL-10, and tumor necrosis factor-alpha) in the presence of azithromycin in EB-stimulated cells from both fertile and infertile women with primary and recurrent C. trachomatis infection. Azithromycin 139-151 interleukin 6 Homo sapiens 68-72 22116002-6 2012 Poly(I:C) stimulated the secretion of IL-6, IL-8, MCP-1, RANTES, IP-10, eotaxin, MIP-1beta, and interferon-gamma, whereas zymosan triggered the production of IL-6, IL-8, and MCP-1. Zymosan 122-129 interleukin 6 Homo sapiens 158-162 22116002-7 2012 LPS, poly(I:C), and zymosan thus each induced a distinct pattern of cytokine and chemokine release from human corneal fibroblasts, with the release of IL-6, IL-8, and MCP-1 being commonly elicited by all three agents. Zymosan 20-27 interleukin 6 Homo sapiens 151-155 21917119-0 2012 Nonylphenol induces bronchial epithelial apoptosis via Fas-mediated pathway and stimulates bronchial epithelium to secrete IL-6 and IL-8, causing bronchial smooth muscle proliferation and migration. nonylphenol 0-11 interleukin 6 Homo sapiens 123-127 21917119-9 2012 This study is the first to demonstrate that NP not only induces bronchial epithelial apoptosis via the Fas-mediated pathway but also stimulates the bronchial epithelium to secrete IL-6 and IL-8, which cause bronchial smooth muscle proliferation and migration - major features in asthma remodelling. nonylphenol 44-46 interleukin 6 Homo sapiens 180-184 22119708-5 2012 All PFCs suppressed LPS-induced TNF-alpha production in hPBL and THP-1 cells, while IL-6 production was suppressed by PFOSA, PFOS, PFDA and fluorotelomer. perfluorodecanoic acid 131-135 interleukin 6 Homo sapiens 84-88 22910558-4 2012 Secretion of the pro-inflammatory cytokines, IL-6 and TNF-alpha, was significantly attenuated in calcitriol-treated VSMC culture, but the level of anti-inflammatory TGF-beta was generally unchanged. Calcitriol 97-107 interleukin 6 Homo sapiens 45-49 23320034-7 2012 Fisetin was added (3-10 muM) for 48 h. While the HG condition significantly induced histone acetylation, NF-kappaB activation, and proinflammatory cytokine (IL-6 and TNF-alpha) release from THP-1 cells, fisetin suppressed NF-kappaB activity and cytokine release. fisetin 0-7 interleukin 6 Homo sapiens 157-161 22154580-7 2012 Risperidone increased the production of IL-10 and MDC as well as the proinflammatory cytokines, such as IL-6, IL-8, and TNF-alpha, but decreased the production of IP-10 and IL-12. Risperidone 0-11 interleukin 6 Homo sapiens 104-108 22213773-4 2012 Pretreatment with 9cisRA for 1 h significantly decreased lipopolysaccharide (LPS)-induced mRNA expression and protein release of tumor necrosis factor (TNF)alpha, interleukin (IL)-6 and chemokine ligands (CCL)3 and CCL4. 9cisra 18-24 interleukin 6 Homo sapiens 163-181 23028840-13 2012 Furthermore, prior remifentanil incubation prevented TNF-alpha-induced IL-6 release of HepG2 cells, and attenuated fragmentation of pro-caspase-3 into cleaved active caspase 3 (an early marker of apoptosis). Remifentanil 19-31 interleukin 6 Homo sapiens 71-75 22129063-6 2011 U0126 (MAPK kinase (MEK)1/2 inhibitor) and SB203580 (p38 MAPK inhibitor) decreased the LPS-enhanced release of IL-6 and GM-CSF. U 0126 0-5 interleukin 6 Homo sapiens 111-115 22655494-9 2011 In the PAVS group, the IL-6 level was higher after 12 months, but the IgM level was higher at the initial visit. EAP protocol 7-11 interleukin 6 Homo sapiens 23-27 21555507-6 2011 IL-6 suppressed induction of CYP1A2 enzyme activity by omeprazole and CYP3A4 enzyme activity by rifampicin but only at supraphysiological concentrations of IL-6. Rifampin 96-106 interleukin 6 Homo sapiens 0-4 21388428-5 2011 Addition of the MAPK kinase (MAPKK) MEK inhibitor U0126 inhibited IL-6/TNF-alpha secretion in a dose-dependent manner. U 0126 50-55 interleukin 6 Homo sapiens 66-70 21801384-14 2011 CONCLUSION: Heteroarylketone compounds are potent inhibitors of IL-6 expression in vitro and in vivo and may represent a new class of potent anti-inflammatory and neuroprotective drugs. heteroarylketone 12-28 interleukin 6 Homo sapiens 64-68 21440540-2 2011 In contrast, the extrinsic TRAIL/TRAIL-Receptor mediated death pathway remained highly active, and exogenous TRAIL in a combination with cycloheximide (CHX) induced higher levels of apoptosis in rho(0) cells compared to rho(+) HSF. Cycloheximide 137-150 interleukin 6 Homo sapiens 227-230 21440540-2 2011 In contrast, the extrinsic TRAIL/TRAIL-Receptor mediated death pathway remained highly active, and exogenous TRAIL in a combination with cycloheximide (CHX) induced higher levels of apoptosis in rho(0) cells compared to rho(+) HSF. Cycloheximide 152-155 interleukin 6 Homo sapiens 227-230 21540553-4 2011 Here, we measured the effect of IL-6 on both endogenous cofactor-mediated and dithiothreitol-stimulated (DTT-stimulated) cell sonicate deiodinase activities in human cell lines. Dithiothreitol 78-92 interleukin 6 Homo sapiens 32-36 21540553-4 2011 Here, we measured the effect of IL-6 on both endogenous cofactor-mediated and dithiothreitol-stimulated (DTT-stimulated) cell sonicate deiodinase activities in human cell lines. Dithiothreitol 105-108 interleukin 6 Homo sapiens 32-36 21315154-4 2011 Three of the four tested macrolides, azithromycin, clarithromycin and roxithromycin, exhibited pronounced, concentration-related reduction of IL-1beta, IL-6, IL-10, TNF-alpha, CCL3, CCL5, CCL20, CCL22, CXCL1, CXCL5, and G-CSF release. Azithromycin 37-49 interleukin 6 Homo sapiens 152-156 21315154-4 2011 Three of the four tested macrolides, azithromycin, clarithromycin and roxithromycin, exhibited pronounced, concentration-related reduction of IL-1beta, IL-6, IL-10, TNF-alpha, CCL3, CCL5, CCL20, CCL22, CXCL1, CXCL5, and G-CSF release. Clarithromycin 51-65 interleukin 6 Homo sapiens 152-156 21316405-5 2011 Inhibition of de novo protein synthesis with cycloheximide resulted in higher levels of IFN-beta1 and IFN-beta2 RNA levels after BHV-1 infection. Cycloheximide 45-58 interleukin 6 Homo sapiens 102-111 21236342-7 2011 Addition of calcitriol normalized the expression, secretion and activity of eNOS, RAGE and IL-6. Calcitriol 12-22 interleukin 6 Homo sapiens 91-95 21294867-9 2011 IL-6 significantly increased only at week 24 from baseline in patients on abacavir (+225%, p < 0.01) although the differences were not significant between groups. abacavir 74-82 interleukin 6 Homo sapiens 0-4 21365246-7 2011 The activation of FUT1, FUT2 and FUT4 by IL-1beta is through the NF-kappaB pathway and the down-regulation of FUT3 and FUT5 by IL-6 is through the gp130/STAT-3 pathway, since they are inhibited specifically by panepoxydone and AG490, respectively. panepoxydone 210-222 interleukin 6 Homo sapiens 127-131 21097658-11 2011 Insomnia subjects, but not good sleepers, showed increased concentrations of IL-6 associated with caffeine use. Caffeine 98-106 interleukin 6 Homo sapiens 77-81 20958132-6 2011 RESULTS: When it was acupunctured at the Ermen acupoint (triple energizer meridian 21) after an administration of cisplatin, PBS-pharmaceutical acupuncture significantly suppressed interleukin (IL)-6 production and caspase-3 activation induced by cisplatin in the cochlea. bamboo salt 125-128 interleukin 6 Homo sapiens 181-199 20958132-7 2011 In addition, PBS significantly inhibited cisplatin-induced apoptosis and IL-6 production in HEI-OC1 cells. bamboo salt 13-16 interleukin 6 Homo sapiens 73-77 22024524-3 2011 In this study, we investigated the association of serum IL-6 levels with outcomes of pegylated interferon (PEG-IFN) plus ribavirin (RBV) combination therapy. peg-ifn 107-114 interleukin 6 Homo sapiens 56-60 22024524-8 2011 In male patients with SVR, serum IL-6 levels decreased significantly at 4 weeks of treatment (P=0.029) and remained significantly lower than those of non-SVR patients after 4, 8 and 12 weeks of PEG-IFN plus RBV therapy. peg-ifn 194-201 interleukin 6 Homo sapiens 33-37 22024524-9 2011 CONCLUSIONS: Our results suggest that baseline levels of IL-6, as well as their decrease during treatment, are correlated to outcomes of PEG-IFN plus RBV therapy in male patients. peg-ifn 137-144 interleukin 6 Homo sapiens 57-61 20950664-6 2011 CbpA could also induce the release of inflammatory cytokine interleukin-6, and chemokines CCL2, CXCL1, and CXCL8 from human bronchial epithelia cells. cbpa 0-4 interleukin 6 Homo sapiens 60-73 22096605-5 2011 METHODOLOGY/PRINCIPAL FINDINGS: Using the T/C-28a2 chondrocyte cell line as a model system, we report that exogenous PGE(2) and PGD(2)/15d-PGJ(2) exert antagonistic effects on IL-6 synthesis in human T/C-28a2 chondrocytes. Prostaglandins D 128-131 interleukin 6 Homo sapiens 176-180 22096605-8 2011 PGD(2) or 15d-PGJ(2) concurrently downregulates TLR4 and upregulates caveolin-1, which in turn inhibit the PGE(2)-dependent ERK1/2, PI3-K and PKA activation, and ultimately with NF-kappaB-dependent IL-6 synthesis in chondrocytes. Prostaglandins D 0-3 interleukin 6 Homo sapiens 198-202 22096605-9 2011 CONCLUSIONS/SIGNIFICANCE: We have delineated the signaling cascade by which PGE(2) and PGD(2)/15d-PGJ(2) exert opposing effects on IL-6 synthesis in human chondrocytes. Prostaglandins D 87-90 interleukin 6 Homo sapiens 131-135 21529308-12 2011 Taken at bedtime (approximately 10:00 pm), these tablets give programmed delivery of prednisone around 4 h later, at the optimal time to suppress IL-6. Prednisone 85-95 interleukin 6 Homo sapiens 146-150 20691261-0 2010 Role of IL-6 trans-signaling in CCl4induced liver damage. ccl4induced 32-43 interleukin 6 Homo sapiens 8-12 20691261-10 2010 Furthermore, IL-6 trans-signaling was important for refilling of hepatocyte glycogen stores, which were depleted 24 h after CCl4 treatment. Glycogen 76-84 interleukin 6 Homo sapiens 13-17 21144938-11 2010 A trend towards higher levels for IL-6 in the SR group was noted at 24 hours post-operatively whereas the IL-10 levels at the post-reaming time point were higher in the RIA group. Strontium 46-48 interleukin 6 Homo sapiens 34-38 21042414-1 2010 5-Androstene-3beta,7beta,17beta-triol (beta-AET), an active metabolite of dehydroepiandrosterone (DHEA), reversed glucocorticoid (GC)-induced suppression of IL-6, IL-8 and osteoprotegerin production by human osteoblast-like MG-63 cells and promoted osteoblast differentiation of human mesenchymal stem cells (MSCs). 7beta 19-24 interleukin 6 Homo sapiens 157-161 20528773-7 2010 The diminished responses of both phenylalanine balance and appearance rate to hyperinsulinaemia-hyperaminoacidaemia were related to greater circulating IL-6 (interleukin-6) levels. Phenylalanine 33-46 interleukin 6 Homo sapiens 152-156 20528773-7 2010 The diminished responses of both phenylalanine balance and appearance rate to hyperinsulinaemia-hyperaminoacidaemia were related to greater circulating IL-6 (interleukin-6) levels. Phenylalanine 33-46 interleukin 6 Homo sapiens 158-171 20421217-9 2010 At similar concentrations, MS-275 and SAHA suppressed LPS-induced NF-kappaB p65 nuclear accumulation and IL-1beta, IL-6, IL-18 and TNF-alpha secretion in THP-1 monocytic cells. entinostat 27-33 interleukin 6 Homo sapiens 115-119 20435648-0 2010 Vitamin D3 down-regulates intracellular Toll-like receptor 9 expression and Toll-like receptor 9-induced IL-6 production in human monocytes. Cholecalciferol 0-10 interleukin 6 Homo sapiens 105-109 20599720-8 2010 BAPTA/AM abolished LPS-induced TNFalpha and IL-6 production, while EGTA only partially suppressed LPS-induced IL-6 production, but not TNFalpha production. 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid 0-5 interleukin 6 Homo sapiens 44-48 20430640-5 2010 To reduce non-specific binding, a mixed self-assembled monolayer of mercaptoundecanoic acid (MUA) and mercaptohexanol (MCH) was attached to the sensor, and then used for IL-6 determination using a sandwich type immunoassay. mercaptoundecanoic acid 68-91 interleukin 6 Homo sapiens 170-174 20228251-1 2010 Oxidative stress induced by inhibition of glutathione (GSH) biosynthesis with D,L-buthionine-S,R-sulfoximine (BSO) causes human microglia, human astrocytes, THP-1 cells, and U373 cells to secrete materials toxic to human neuroblastoma SH-SY5Y cells and stimulates them to release TNF-alpha, IL-6, and nitrite ions. Buthionine Sulfoximine 110-113 interleukin 6 Homo sapiens 291-295 20107167-7 2010 RESULTS: Zymosan induced the release of IL-6 and IL-8 from corneal fibroblasts without affecting either the release of IL-1beta, IL-12, IP-10, or RANTES or the expression of ICAM-1 or VCAM-1. Zymosan 9-16 interleukin 6 Homo sapiens 40-44 20107167-9 2010 The zymosan-induced release of IL-6 and IL-8 was attenuated by inhibitors of ERK, p38, JNK, and NF-kappaB signaling. Zymosan 4-11 interleukin 6 Homo sapiens 31-35 20107167-10 2010 CONCLUSIONS: Zymosan induces the release of IL-6 and IL-8 from human corneal fibroblasts in a manner dependent on MAPK and NF-kappaB signaling pathways. Zymosan 13-20 interleukin 6 Homo sapiens 44-48 19427777-5 2010 Interleukin (IL)-1beta, IL-6 and tumor necrosis factor-alpha secretion from EPA, DHA and control cells were differentially limited by LPS concentration. Dihydroalprenolol 81-84 interleukin 6 Homo sapiens 24-60 20106948-0 2010 Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling. Kynurenic Acid 0-14 interleukin 6 Homo sapiens 100-113 20487003-6 2010 The presence of EGCG and ECG significantly reduced, in a concentration-dependent manner, the expression of IL-6 and IL-8 in dental pulp cells exposed to LPS or PG. epicatechin gallate 25-28 interleukin 6 Homo sapiens 107-111 20089808-7 2010 An aminopyridine-based JNK inhibitor, N-(4-amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide (JNK inhibitor VIII), inhibited phosphorylation of a JNK substrate c-Jun but did not have any effect on IL-6, IL-8, or COX-2 expression. Aminopyridines 3-16 interleukin 6 Homo sapiens 216-220 20131233-9 2010 Increased expression of tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and IL-6 induced by lipopolysaccharide was attenuated by cilostazol and CoPP, and this was reversed by ZnPP. cobaltiprotoporphyrin 166-170 interleukin 6 Homo sapiens 98-102 20133495-10 2010 Furthermore, in the labetalol group, there were significant differences of 30% in CD40 ligand (P < .005 time and group comparison), 22% in IL-6 (P < .005 time and group comparison), and 18% in choline (P < .005 time and group comparison). Labetalol 20-29 interleukin 6 Homo sapiens 142-146 20007751-5 2010 Cholecalciferol therapy reduced circulating levels of inflammatory cytokines, including IL-8, IL-6, and TNF. Cholecalciferol 0-15 interleukin 6 Homo sapiens 94-98 19939912-10 2010 Furthermore, in the presence of an acute GR knockdown as well as in GR knockout adipocytes, corticosterone increased the gene expression of the pro-inflammatory adipokines IL6 and MCP1. Corticosterone 92-106 interleukin 6 Homo sapiens 172-175 20000589-3 2010 Screening of indole metabolites has identified indoxyl 3-sulfate (I3S) as a potent endogenous ligand that selectively activates the human AHR at nanomolar concentrations in primary human hepatocytes, regulating transcription of multiple genes, including CYP1A1, CYP1A2, CYP1B1, UGT1A1, UGT1A6, IL6, and SAA1. inositol 1,3,4-trisphosphate 66-69 interleukin 6 Homo sapiens 294-297 20439185-0 2010 Vitamin D derivatives: calcitriol and tacalcitol inhibits interleukin-6 and interleukin-8 expression in human nasal polyp fibroblast cultures. Calcitriol 23-33 interleukin 6 Homo sapiens 58-71 20378994-2 2010 We demonstrate that agaro-oligosaccharides suppressed the elevated levels of nitric oxide, prostaglandin E(2), and such pro-inflammatory cytokines as tumor necrosis factor-alpha, interleukin-1beta and interleukin-6 in lipopolysaccharide-stimulated monocytes and macrophages. agaro-oligosaccharides 20-42 interleukin 6 Homo sapiens 201-214 20072651-4 2010 Treatment of myeloma cells with INCB16562 potently inhibited interleukin-6 (IL-6)-induced phosphorylation of STAT3. INCB 16562 32-41 interleukin 6 Homo sapiens 61-74 20072651-4 2010 Treatment of myeloma cells with INCB16562 potently inhibited interleukin-6 (IL-6)-induced phosphorylation of STAT3. INCB 16562 32-41 interleukin 6 Homo sapiens 76-80 19766327-4 2009 The current study investigated the effects of luteolin, a citrus bioflavonoid, and its structural analog, diosmin, on IL-6 induced JAK2/STAT3 (Janus tyrosine kinase-2/signal transducer and activator of transcription-3) phosphorylation and signaling as well as behavioral phenotypes of MIA offspring. Luteolin 46-54 interleukin 6 Homo sapiens 118-122 19759193-6 2009 Caffeic acid phenethyl ester and parthenolide inhibited NF-kappaB activation, as seen by gel shift assays and immunoblotting for p65 in nuclear fractions, as well as decreased production of IL-6 and MCP-1. caffeic acid phenethyl ester 0-28 interleukin 6 Homo sapiens 190-194 20074471-3 2009 The aim of this study is to investigate whether tetrabromofluorecin, commonly know as eosin, a classical compound traditionally topically used in psoriasis for its presumed anti-inflammatory activities, is able to modulate the production of TNF-alpha, IL-6 and IL-8 that are recognized as the most active and characterized cytokines in the pathogenesis of this skin disorder. tetrabromofluorecin 48-67 interleukin 6 Homo sapiens 252-256 19706767-6 2009 Addition of DTT or glutathione prevents the JAK cross-linking and blocks the inhibitory effects of HJB on IL-6-induced STAT3 activation, suggesting that HJB may react with cystein residues of JAKs to form covalent bonds that inactivate JAKs. Dithiothreitol 12-15 interleukin 6 Homo sapiens 106-110 19564341-4 2009 Further investigation revealed that the addition of T15-NAb significantly suppressed in vitro LPS-induced TNF-alpha and IL-6 secretion by the macrophage-like cell line, RAW264.7, as well as TLR3-, TLR4-, TLR7-, and TLR9-induced maturation and secretion of a range of proinflammatory cytokines and chemokines by bone marrow-derived conventional dendritic cells. t15-nab 52-59 interleukin 6 Homo sapiens 120-124 19434815-6 2009 CONCLUSIONS: Treatment with levamisole and colchicine can result in a significant reduction of serum IL-6, IL-8 or TNF-alpha level in MCBD patients. Colchicine 43-53 interleukin 6 Homo sapiens 101-105 19330649-0 2009 Interleukin-6-independent expression of glucocorticoid receptor is upregulated by triptolide in multiple myeloma. triptolide 82-92 interleukin 6 Homo sapiens 0-13 19162100-4 2009 CDM exerted a potent anti-HSV-1 effect on corneal cells and inhibited NF-kappaB translocation to the nucleus, leading to a decrease in IL-6 production. 1-cinnamoyl-3,11-dihydroxymeliacarpin 0-3 interleukin 6 Homo sapiens 135-139 19129218-6 2009 Hsf is a substrate of mitogen-activated protein kinase and S378 is the major phosphorylation site. 3-(2-chloroethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 59-63 interleukin 6 Homo sapiens 0-3 19215806-10 2009 In line with data from adult whole blood cultures, SFA proved to be a strong inhibitor of LPS-induced expression of IL-6 and TNF-alpha in the neonatal whole blood system. sanglifehrin A 51-54 interleukin 6 Homo sapiens 116-120 18686109-4 2009 While pure phenolics at the concentration of 20 mM did not significantly affect PBMC cytokine secretion, BTE and Polyphenon 60 suppressed interleukin-1 beta, tumor necrosis factor-alpha and interleukin-6. polyphenon 113-123 interleukin 6 Homo sapiens 190-203 18945671-6 2008 The ability of eNampt to trigger this IL-6/STAT3 cell survival pathway did not depend on the presence of the Nampt enzymatic substrate nicotinamide in the medium, could not be mimicked by the Nampt enzymatic product nicotinamide mononucleotide (NMN), was not blocked by the Nampt enzyme inhibitor FK866, and showed no correlation with enzyme activity in a series of site-directed mutant Nampt proteins. N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide 297-302 interleukin 6 Homo sapiens 38-42 18368033-5 2008 The results show that glucocorticoids (dexamethasone, prednisolone, cortisol and corticosterone) caused a concentration-dependent inhibition of LPS-stimulated IL-6 levels. Corticosterone 81-95 interleukin 6 Homo sapiens 159-163 18375611-1 2008 BACKGROUND: The guanidine to cytosine transition at position -174 nucleotides relative to the transcription start site in the interleukin (IL)-6 gene has been implicated as a genetic risk factor for the development of sepsis in very low birth weight (VLBW) infants. Guanidine 16-25 interleukin 6 Homo sapiens 126-144 18631349-8 2008 3-hydroxy fatty acid (C(10:0)-C(14:0)) levels in bed dust were inversely associated with the production of TNF-alpha and IL-6 in blood samples of mothers and their 3-month-old children. 3-hydroxy fatty acid 0-20 interleukin 6 Homo sapiens 121-125 18502099-5 2008 Interestingly, we found that Sp1 was eliminated from the IL-6 promoter after treatment with the ERK inhibitor U0126. U 0126 110-115 interleukin 6 Homo sapiens 57-61 18502099-6 2008 The importance of ERK and Sp1 in regulating IL-6 transcription was, furthermore, supported by the observation that treatment of U266 cells with U0126 or mithramycin, an antibiotic that prevents Sp1-DNA binding, abrogated constitutive IL-6 transcription. U 0126 144-149 interleukin 6 Homo sapiens 44-48 18502099-6 2008 The importance of ERK and Sp1 in regulating IL-6 transcription was, furthermore, supported by the observation that treatment of U266 cells with U0126 or mithramycin, an antibiotic that prevents Sp1-DNA binding, abrogated constitutive IL-6 transcription. U 0126 144-149 interleukin 6 Homo sapiens 234-238 18717824-11 2008 CONCLUSIONS: The decreased NFkappaB and p38 activities followed by calcitriol treatment may explain the anti-inflammatory/atherosclerotic properties of calcitriol that were observed previously and were emphasized in this study, demonstrating the inhibitory effect of calcitriol on the pro-inflammatory parameters: adhesion molecules, RAGE and IL-6. Calcitriol 152-162 interleukin 6 Homo sapiens 343-347 18285417-10 2008 Finally, change in the PYR/Cr ratio was positively associated baseline IL-6, hs-CRP, and their changes (all P < 0.05) in women, but not men. pyridinoline 23-26 interleukin 6 Homo sapiens 71-75 19124359-9 2008 CONCLUSION: In ex-smokers with severe COPD, a measure of local pulmonary inflammation, FENO, may be more closely associated with FEV1 responses to four weeks of ICS than are standard markers of systemic inflammation, serum CRP, IL-6, and IL-8. flubendiamide 87-91 interleukin 6 Homo sapiens 228-232 17915188-7 2008 The pretreatment of SaM-1 cells with U-73122, a phospholipase C (PLC) inhibitor, and 2-APB also inhibited the increase in IL-6 and IL-8 synthesis in response to LPA. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 37-44 interleukin 6 Homo sapiens 122-126 17993646-4 2008 Here we show that rapamycin, the inhibitor of mTOR signaling, rescues insulin signaling and glycogen synthesis from IL-6 inhibition in HepG2 hepatocarcinoma cells as well as in mouse primary hepatocytes. Glycogen 92-100 interleukin 6 Homo sapiens 116-120 18082489-5 2008 RESULTS: From baseline to day 1, the levels of interleukin 6 and the expression of tumor necrosis factor alpha mRNA increased significantly in the mBMC group compared to the control group (P < .05 for both). mbmc 147-151 interleukin 6 Homo sapiens 47-60 18082489-6 2008 The decrease in interleukin 6 levels from baseline to 2 to 3 weeks in the mBMC group was less pronounced than in the controls (P < .05), as was also the decrease in C-reactive protein levels from baseline to day 1 and day 3 in the mBMC group (P < .05). mbmc 74-78 interleukin 6 Homo sapiens 16-29 18082489-6 2008 The decrease in interleukin 6 levels from baseline to 2 to 3 weeks in the mBMC group was less pronounced than in the controls (P < .05), as was also the decrease in C-reactive protein levels from baseline to day 1 and day 3 in the mBMC group (P < .05). mbmc 234-238 interleukin 6 Homo sapiens 16-29 17761160-0 2007 Cooperation of calcineurin and ERK for UTP-induced IL-6 production in HaCaT keratinocytes. Uridine Triphosphate 39-42 interleukin 6 Homo sapiens 51-55 17761160-1 2007 UTP causes IL-6 production in HaCaT keratinocytes, which is partially inhibited by PD98059, a mitogen-activated protein kinase kinase (MEK) inhibitor, suggesting that a pathway other than the extracellular signal-regulated kinase (ERK) pathway is involved in the production. Uridine Triphosphate 0-3 interleukin 6 Homo sapiens 11-15 17761160-3 2007 FK506 and cyclosporine A, calcineurin inhibitors, partially inhibited UTP-induced IL-6 mRNA expression and protein production. Uridine Triphosphate 70-73 interleukin 6 Homo sapiens 82-86 17761160-4 2007 In addition, combined application of FK506 and PD98059 synergistically inhibited the UTP-induced IL-6 production. Uridine Triphosphate 85-88 interleukin 6 Homo sapiens 97-101 17667842-8 2007 AZM significantly reduced the IL-6 and IL-8 production to the levels similar to control. Azithromycin 0-3 interleukin 6 Homo sapiens 30-34 17512639-4 2007 Some regulated transcripts, for example, were related to BDNF/TrkB, IL-6/Jak2/Socs2 and TGF/follistatin signaling; many transcripts affected bioactive peptide and polyamine biosynthesis. Polyamines 163-172 interleukin 6 Homo sapiens 68-72 17112620-8 2007 1,25-Dihydroxyvitamin D(3) was able to down-regulate the expression of TNF-alpha, IL-6, IL-1, and IL-8, confirming its immunomodulatory properties. Calcitriol 0-26 interleukin 6 Homo sapiens 82-86 17531588-8 2007 Smoking appeared to modify the associations of ICA-IMT with CRP (p = 0.009) and with IL-6 (p = 0.006); the association was more pronounced in current (vs former or never) smokers. isocyanic acid 47-50 interleukin 6 Homo sapiens 85-89 17408606-5 2007 Median IL-6 (p<0.001) and hs-CRP (p<0.01) levels on admission were significantly increased in patients with AMI compared with patients with NICP or UA. nicp 146-150 interleukin 6 Homo sapiens 7-11 17118622-8 2007 In addition, DNCB and NiSO(4) augmented CD1a expression and production of IL-6, respectively. niso 22-26 interleukin 6 Homo sapiens 74-78 17114176-7 2007 The addition of fosfomycin significantly inhibited mRNA levels of pro-inflammatory cytokines such as IL-1-alpha, IL-6 and TNF-alpha after 2 h (P < 0.01), while no significant reduction was observed for the anti-inflammatory cytokines IL-4, IL-10 and IL-13 (P = 0.26). Fosfomycin 16-26 interleukin 6 Homo sapiens 113-117 17114176-9 2007 Addition of fosfomycin significantly reduced cytokine levels by 56% and 73% for IL-6 and TNF-alpha, respectively. Fosfomycin 12-22 interleukin 6 Homo sapiens 80-84 18297990-17 2007 Patients with higher CAS scores (6-10) had a change in IL-6 levels (from 1.32+/-1.00 to 2.67 +/- 4.84; p > 0.05). cas 21-24 interleukin 6 Homo sapiens 55-59 17079162-4 2007 Fisetin decreased phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated gene expression and production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-4, IL-6, and IL-8 in HMC-1 cells. fisetin 0-7 interleukin 6 Homo sapiens 204-208 17130674-0 2006 Contribution of extracellular signal-regulated kinase to UTP-induced interleukin-6 biosynthesis in HaCaT keratinocytes. Uridine Triphosphate 57-60 interleukin 6 Homo sapiens 69-82 17130674-2 2006 In the present study, we analyzed the mechanism of UTP-induced IL-6 production in these cells. Uridine Triphosphate 51-54 interleukin 6 Homo sapiens 63-67 17130674-5 2006 2-APB [(2-aminoethoxy)diphenylborane], an inositol 1,4,5-trisphosphate (IP(3))-receptor antagonist, inhibited UTP-induced IL-6 mRNA expression; and the action of A23187, a Ca(2+) ionophore, resembled the action of UTP. Uridine Triphosphate 110-113 interleukin 6 Homo sapiens 122-126 17049124-5 2006 RESULTS: The peptide has the ability to interact with the NF-kappaB p50 subunit and can effectively inhibit TNF-alpha and IL-6 production in the THP-1 cell line, PMA-induced ear edema and zymosan A-induced peritonitis in mice. Zymosan 188-197 interleukin 6 Homo sapiens 122-126 17197193-11 2006 AG490, SB203580, piceatannol, parthenolide and cycloheximide inhibit CT-1 induced IL-6 mRNA and protein expression whereas wortmannin and PD98059 did not inhibit IL-6 expression. 3,3',4,5'-tetrahydroxystilbene 17-28 interleukin 6 Homo sapiens 82-86 17197193-11 2006 AG490, SB203580, piceatannol, parthenolide and cycloheximide inhibit CT-1 induced IL-6 mRNA and protein expression whereas wortmannin and PD98059 did not inhibit IL-6 expression. Cycloheximide 47-60 interleukin 6 Homo sapiens 82-86 16822504-3 2006 We used flow cytometry and an ARPE-19 cell model to determine the effect of GS on the production of ICAM-1 in response to IL-1beta, IL-6, tumor necrosis factor (TNF)-alpha plus IL-1beta, TNF-alpha plus IL-6, and TNF-alpha plus interferon (IFN)-gamma. Glucosamine 76-78 interleukin 6 Homo sapiens 132-136 16968805-13 2006 Lovastatin significantly decreased Rho kinase and nuclear factor-kappaB activity, significantly increased Akt activity, and resulted in decreased monocyte IL-6 levels; these effects were reversed with mevalonate and geranylgeranyl pyrophosphate, indicating direct effects of statins on protein prenylation. Lovastatin 0-10 interleukin 6 Homo sapiens 155-159 16924534-0 2006 Prostaglandin D2 and J2-series (PGJ2, Delta12-PGJ2) prostaglandins stimulate IL-6 and MCP-1, but inhibit leptin, expression and secretion by 3T3-L1 adipocytes. Prostaglandin D2 0-16 interleukin 6 Homo sapiens 77-81 16924534-5 2006 In contrast, PGD(2) induced a marked stimulation of IL-6 and MCP-1 expression; with IL-6, this was rapid, the mRNA level increasing by >50-fold by 1 h. The rise in mRNA was accompanied by an increase in IL-6 and MCP-1 release (up to 100- and 6.5-fold, respectively). Prostaglandin D2 13-19 interleukin 6 Homo sapiens 52-56 16924534-5 2006 In contrast, PGD(2) induced a marked stimulation of IL-6 and MCP-1 expression; with IL-6, this was rapid, the mRNA level increasing by >50-fold by 1 h. The rise in mRNA was accompanied by an increase in IL-6 and MCP-1 release (up to 100- and 6.5-fold, respectively). Prostaglandin D2 13-19 interleukin 6 Homo sapiens 84-88 21155263-6 2006 In addition, the levels of supernatant IL-6 and NO were increased clearly in zinc deficiency group and corticosterone stressed groups. Corticosterone 103-117 interleukin 6 Homo sapiens 39-43 17216018-0 2006 [Anabolic effects and inhibition of interleukin 6 production induced by neridronate on human osteoblasts]. 6-amino-1-hydroxyhexane-1,1-diphosphonate 72-83 interleukin 6 Homo sapiens 36-49 16801397-3 2006 MEK inhibitor U0126 or RNA interference (RNAi) for BRAF(V600E) decreased production of the immunosuppressive soluble factors interleukin (IL)-10, VEGF, or IL-6 from melanoma cells to levels comparable to those after signal transducer and activator of transcription (STAT)3 inactivation. U 0126 14-19 interleukin 6 Homo sapiens 155-159 16843089-7 2006 Nonosmotic stimulation of arginine vasopressin secretion may be mediated in part by enhanced release of muscle-derived interleukin-6 during glycogen depletion, linking exertional rhabdomyolysis to the pathogenesis of EAH. Glycogen 140-148 interleukin 6 Homo sapiens 119-132 16633892-14 2006 When added in the presence of lipopolysaccharide, CGP42112 reduced the lipopolysaccharide-stimulated secretion of the pro-inflammatory cytokines TNF-alpha, IL-1, IL-1 beta, and IL-6, and increased protein kinase A. CGP 42112A 50-58 interleukin 6 Homo sapiens 177-181 16716291-7 2006 While a protein kinase C inhibitor (GF109203X, 10 microM) was without effect, an intracellular free Ca2+ chelator (BAPTA-AM, 50 microM) suppressed UTP-mediated IL-6 induction. Uridine Triphosphate 147-150 interleukin 6 Homo sapiens 160-164 16755241-6 2006 The mechanism of action is thought to be that aminobisphosphonates transiently stimulate the production of proinflammatory cytokines such as interleukin-1, interleukin-6, and tumor necrosis factor-alpha. aminobisphosphonates 46-66 interleukin 6 Homo sapiens 156-169 16381797-5 2006 Inhibitors of IP(3)-dependent Ca(2+) signals, like 2-aminoethoxydiphenyl borate (2-APB) and U-73122, decreased activation of IL-6 gene expression as did Ca(2+) signals inhibitor BAPTA-AM, whereas ryanodine, a fast Ca(2+) transient inhibitor, had no effect on IL-6 induction. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 92-99 interleukin 6 Homo sapiens 125-129 16381797-6 2006 Depolarization of myotubes transiently transfected with a reporter gene construct, containing 651 bp of IL-6 promoter, induced a twofold increase in promoter activity, which was abolished by either 2-APB or U-73122 and remained unaffected after ryanodine treatment. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 207-214 interleukin 6 Homo sapiens 104-108 16306311-6 2006 Participants with the highest serum levels of alpha-carotene, total carotenoids, and selenium were significantly less likely to be in the highest tertile of serum IL-6 at baseline (p < 0.0001). alpha-carotene 46-60 interleukin 6 Homo sapiens 163-167 16306311-7 2006 Those with the lowest levels of alpha- and beta-carotene, lutein/zeaxanthin, and total carotenoids were significantly more likely to have increasing IL-6 levels over a period of 2 years. alpha- and beta-carotene 32-56 interleukin 6 Homo sapiens 149-153 16306311-7 2006 Those with the lowest levels of alpha- and beta-carotene, lutein/zeaxanthin, and total carotenoids were significantly more likely to have increasing IL-6 levels over a period of 2 years. Zeaxanthins 65-75 interleukin 6 Homo sapiens 149-153 16888370-11 2006 After 16 weeks of calcitriol treatment, the correlation between IL-6 and iPTH levels lost significance but levels of serum IL-6, bAP and TRACP5b remained significantly correlated. Calcitriol 18-28 interleukin 6 Homo sapiens 64-68 16888370-11 2006 After 16 weeks of calcitriol treatment, the correlation between IL-6 and iPTH levels lost significance but levels of serum IL-6, bAP and TRACP5b remained significantly correlated. Calcitriol 18-28 interleukin 6 Homo sapiens 123-127 16888370-12 2006 CONCLUSIONS: Elevated levels of serum IL-6 and bone remodeling markers, namely, bAP and TRACP5b which are common features of SHP, are effectively suppressed by calcitriol therapy. Calcitriol 160-170 interleukin 6 Homo sapiens 38-42 16526817-8 2006 Treating PPG with glinides improves IMT as well as interleukin-6 and C-reactive protein levels, while treating PPG with rapid-acting insulin analogues is also associated with improvements in endothelial dysfunction. glinides 18-26 interleukin 6 Homo sapiens 51-64 16398698-0 2006 Immunosuppressive activity of the immunophilin-binding drug Sanglifehrin A in human whole blood: potent inhibition of interleukin-6 produced by lymphocytes and monocytes. sanglifehrin A 60-74 interleukin 6 Homo sapiens 118-131 16398698-11 2006 Considering the pleiotropic role of bioactive IL-6 production at the interface of innate and acquired immunity in a variety of disease conditions, it was found that these novel aspects of the unique immunosuppressive action could strongly impact on future clinical application of SFA. sanglifehrin A 280-283 interleukin 6 Homo sapiens 46-50 16325157-4 2005 In microglia stimulated with LPS and IFN-gamma, nicergoline suppressed the production of superoxide anions, interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha in a dose-dependent manner. Nicergoline 48-59 interleukin 6 Homo sapiens 132-136 16099893-4 2005 In the present study, we aimed to investigate the effect of exercise, training, and glycogen availability, factors known to affect IL-6, on the regulation of gene expression of the IL-6R in human skeletal muscle. Glycogen 84-92 interleukin 6 Homo sapiens 131-135 16155293-5 2005 Pretreatment with selective NFkappaB inhibitors and the MEK/ERK inhibitor U0126 blocked CLA-mediated IL-6 gene expression. U 0126 74-79 interleukin 6 Homo sapiens 101-105 16708557-0 2005 [The influence of IL-6 polymorphism on efficacy of treatment of rheumatoid arthritis patients with methotrexate and prednisone]. Prednisone 116-126 interleukin 6 Homo sapiens 18-22 16708557-5 2005 The aim of the present study was to examine the influence of - 174 interleukin-6 (IL-6) promoter polymorphism on the efficacy of treatment of RA patients with methotrexate and prednisone. Prednisone 176-186 interleukin 6 Homo sapiens 67-80 16708557-5 2005 The aim of the present study was to examine the influence of - 174 interleukin-6 (IL-6) promoter polymorphism on the efficacy of treatment of RA patients with methotrexate and prednisone. Prednisone 176-186 interleukin 6 Homo sapiens 82-86 15755769-0 2005 Interleukin-6 acts as insulin sensitizer on glycogen synthesis in human skeletal muscle cells by phosphorylation of Ser473 of Akt. Glycogen 44-52 interleukin 6 Homo sapiens 0-13 15755769-1 2005 Previous studies showed an insulin-"desensitizing" action of IL-6 on glycogen synthesis in hepatocytes. Glycogen 69-77 interleukin 6 Homo sapiens 61-65 15755769-3 2005 Because these data indicate a possible tissue-specific effect of IL-6, we investigated the influence of IL-6 on insulin-stimulated glycogen synthesis in these cells. Glycogen 131-139 interleukin 6 Homo sapiens 104-108 15755769-6 2005 Accordingly, IL-6 enhanced glycogen synthesis in the presence of 3 and 10 nM insulin, whereas IL-6 alone had only a marginal effect. Glycogen 27-35 interleukin 6 Homo sapiens 13-17 15755769-9 2005 Together, our data demonstrate a novel insulin-sensitizing function of IL-6 on glycogen synthesis in skeletal muscle cells and indicate that IL-6 exerts cell/tissue-specific effects on insulin action. Glycogen 79-87 interleukin 6 Homo sapiens 71-75 15878941-4 2005 After ARVM were exposed to IL-6 for 2-24 h, intracellular cGMP contents were time dependently increased; this was mimicked by a NO donor and abolished by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), an inhibitor of soluble guanylyl cyclase (sGC), or Rp-8-Br-cGMP, an inhibitor of cGMP-dependent protein kinase G (PKG). rp-8-br-cgmp 256-268 interleukin 6 Homo sapiens 27-31 15779068-7 2005 TAS reduced mRNA levels of COX-2, TNF-alpha, IL-8, IL-6, and IL-1alpha, while resveratrol impaired early expression of IL-8 and TNF-alpha. tas 0-3 interleukin 6 Homo sapiens 51-55 15769552-1 2005 As we have shown earlier, the stable adenosine analogue NECA (N6-(R)-phenylisopropyladenosine) stimulates IL-6 expression in the human astrocytoma cell line U373 MG via the A(2b) receptor. (R)-PIA 62-93 interleukin 6 Homo sapiens 106-110 15689417-6 2005 In iAs-treated rVSMCs, catalase, dimethylsulfoxide, and L-omega-nitro-L-arginine significantly inhibited the increase in expression of all three genes, allopurinol inhibited the increase in MCP-1 and IL-6 expression, but had no effect on HO-1 expression, while superoxide dismutase had no significant effect on HO-1 expression, but had an inhibitory effect on IL-6 expression and a stimulatory effect on MCP-1 expression. l-omega-nitro-l-arginine 56-80 interleukin 6 Homo sapiens 200-204 15689417-6 2005 In iAs-treated rVSMCs, catalase, dimethylsulfoxide, and L-omega-nitro-L-arginine significantly inhibited the increase in expression of all three genes, allopurinol inhibited the increase in MCP-1 and IL-6 expression, but had no effect on HO-1 expression, while superoxide dismutase had no significant effect on HO-1 expression, but had an inhibitory effect on IL-6 expression and a stimulatory effect on MCP-1 expression. l-omega-nitro-l-arginine 56-80 interleukin 6 Homo sapiens 360-364 15831279-11 2005 In addition, pretreatment with U0126 restored the IL-6-induced suppression of aromatase activity. U 0126 31-36 interleukin 6 Homo sapiens 50-54 15831279-13 2005 U0126 markedly reduced the level of the IL-6-induced phosphorylation of ERK1/2. U 0126 0-5 interleukin 6 Homo sapiens 40-44 15696567-8 2005 After 4 weeks of prednisone therapy, ESR was elevated in 13.2% patients, CRP in 41.9%, and serum IL-6 in 37.2%. Prednisone 17-27 interleukin 6 Homo sapiens 97-101 15542282-7 2004 The effect of TBARS on events and procedures was also seen in a multivariate model adjusted for inflammatory markers (C-reactive protein, soluble intercellular adhesion molecule-1, interleukin-6), and other risk factors (age, low-density lipoprotein, high-density lipoprotein, total cholesterol, triglycerides, body mass index, and blood pressure). Thiobarbituric Acid Reactive Substances 14-19 interleukin 6 Homo sapiens 181-194 15543343-11 2004 IL-6 levels decreased significantly in the fenofibrate group (39%; p <0.0001), but not in the cerivastatin group (15%; p = 0.24) No significant decreases were observed for TNF-alpha. Fenofibrate 43-54 interleukin 6 Homo sapiens 0-4 15543343-15 2004 Fenofibrate also significantly decreased IL-6. Fenofibrate 0-11 interleukin 6 Homo sapiens 41-45 15072962-0 2004 Cytokine gene expression in human skeletal muscle during concentric contraction: evidence that IL-8, like IL-6, is influenced by glycogen availability. Glycogen 129-137 interleukin 6 Homo sapiens 106-110 15072962-11 2004 Furthermore, the mRNA abundance of IL-6 and IL-8 appears to be influenced by glycogen availability in the contracting muscle. Glycogen 77-85 interleukin 6 Homo sapiens 35-39 15240743-12 2004 In turn, these cytokines stimulate the expression of IL-15, IL-8, and IL-6 in RASFibs, thereby creating a feedback loop that favors persistent synovial inflammation. rasfibs 78-85 interleukin 6 Homo sapiens 70-74 15298045-9 2004 The IL-6 levels correlated well negatively with delta EDVI (r = 0.779, p = 0.039), whereas no correlation was found for TNF-alpha. edvi 54-58 interleukin 6 Homo sapiens 4-8 15221865-9 2004 CBA values were correlated (r2 > 0.89; P < 0.001) with our reference methods, but were lower on CBA (TNFalpha 45% +/- 8; IL-6 49% +/- 7), probably due to interactions with patients" serum, as confirmed by spiking diluted standards in one patient"s serum with end stage renal failure and high levels of TNF soluble receptor (i.e., TNFalpha levels 34 and 21%). cba 0-3 interleukin 6 Homo sapiens 127-131 14634855-2 2004 In addition, preoperative administration of ibuprofen has proved to reduce interleukin-6 (IL-6) release, while that of ranitidine reduced postoperative IL-6-induced C-reactive protein synthesis in patients undergoing abdominal surgery. Ranitidine 119-129 interleukin 6 Homo sapiens 152-156 15252403-8 2004 Incubation with 0.016 microg/mL azithromycin decreased IL-6 levels to a mean of 1516 +/- 402 pg/mL, and incubation with 0.125 and 1 microg/mL azithromycin decreased IL-6 to 871 +/- 364 and 752 +/- 403 pg/mL, respectively. Azithromycin 32-44 interleukin 6 Homo sapiens 55-59 15252403-8 2004 Incubation with 0.016 microg/mL azithromycin decreased IL-6 levels to a mean of 1516 +/- 402 pg/mL, and incubation with 0.125 and 1 microg/mL azithromycin decreased IL-6 to 871 +/- 364 and 752 +/- 403 pg/mL, respectively. Azithromycin 32-44 interleukin 6 Homo sapiens 165-169 15252403-10 2004 The interaction of C pneumoniae with azithromycin treatment was significant, indicating an inhibitory effect of azithromycin on C pneumoniae-induced IL-6 production. Azithromycin 37-49 interleukin 6 Homo sapiens 149-153 15252403-10 2004 The interaction of C pneumoniae with azithromycin treatment was significant, indicating an inhibitory effect of azithromycin on C pneumoniae-induced IL-6 production. Azithromycin 112-124 interleukin 6 Homo sapiens 149-153 15252403-16 2004 Azithromycin reduces C pneumoniae-induced IL-6 production, but not fibrinogen production, by human hepatocytes. Azithromycin 0-12 interleukin 6 Homo sapiens 42-46 15269990-9 2004 CONCLUSION: During cardiac surgery (mitral valve replacement) PGE1 may suppressed the production of IL-6, IL-8 but not IL-10, which may be related to its myocardial protection effect. Alprostadil 62-66 interleukin 6 Homo sapiens 100-104 14749354-7 2004 The induction by forskolin plus DHT or by either agent or by IL-6 alone was greatly inhibited by H-89, indicating the involvement of protein kinase A in the actions of forskolin, DHT, and IL-6. Dihydrotestosterone 32-35 interleukin 6 Homo sapiens 188-192 14749354-7 2004 The induction by forskolin plus DHT or by either agent or by IL-6 alone was greatly inhibited by H-89, indicating the involvement of protein kinase A in the actions of forskolin, DHT, and IL-6. Dihydrotestosterone 179-182 interleukin 6 Homo sapiens 61-65 15217654-11 2004 CONCLUSIONS: PGE(1)-induced hypotension has an effect on IL-6 response to oral and maxillofacial surgery. Alprostadil 13-19 interleukin 6 Homo sapiens 57-61 14764586-0 2004 Global suppression of IL-6-induced acute phase response gene expression after chronic in vivo treatment with the peroxisome proliferator-activated receptor-alpha activator fenofibrate. Fenofibrate 172-183 interleukin 6 Homo sapiens 22-26 14973543-7 2004 An intra-articular injection of zymosan, 3 days after Ad5.IL-1/IL-6-Luc, increased Luc. Zymosan 32-39 interleukin 6 Homo sapiens 63-67 15106891-7 2004 increased sensitivity of osteoclast-precursors to 1,25(OH)2Vitamin D3 and RANKL, mediated by IL6 have been described as a possible mechanism. Calcitriol 50-69 interleukin 6 Homo sapiens 93-96 14678569-11 2003 Pre-treatment with low doses of DMBA or TCDD selectively abrogated IL-6 gene induction but had no effect on LIF mRNA. 9,10-Dimethyl-1,2-benzanthracene 32-36 interleukin 6 Homo sapiens 67-71 14678569-12 2003 Real-time-PCR indicated a significant inhibition of IL-6 mRNA by AhR ligands within 1 hour of LPS challenge which was reflected in a profound down-regulation of IL-6 protein induction, with DMBA and TCDD suppressing IL-6 levels as much as 65% and 88%, respectively. 9,10-Dimethyl-1,2-benzanthracene 190-194 interleukin 6 Homo sapiens 52-56 14678569-14 2003 EMSAs measuring NF-kappaB binding to IL-6 promoter sequences, an event known to induce IL-6 transcription, indicated a significant decrease in the LPS-mediated induction of DNA-binding RelA/p50 and c-Rel/p50 heterodimers in the presence of DMBA. 9,10-Dimethyl-1,2-benzanthracene 240-244 interleukin 6 Homo sapiens 37-41 14678569-14 2003 EMSAs measuring NF-kappaB binding to IL-6 promoter sequences, an event known to induce IL-6 transcription, indicated a significant decrease in the LPS-mediated induction of DNA-binding RelA/p50 and c-Rel/p50 heterodimers in the presence of DMBA. 9,10-Dimethyl-1,2-benzanthracene 240-244 interleukin 6 Homo sapiens 87-91 14708413-5 2003 The intravenous calcitriol treatment group showed significant decreases in levels of iPTH, TNF-alpha, IL-1 and IL-6 and a significant increase in total calcium level after 3 and 6 months. Calcitriol 16-26 interleukin 6 Homo sapiens 111-115 12730073-9 2003 The protective effects of both IL-6 and IL-11 were not associated with any changes in antioxidants and were decreased by approximately 80% in the presence of U0126, a specific inhibitor of MEK-1-dependent pathways. U 0126 158-163 interleukin 6 Homo sapiens 31-35 12873450-8 2003 Baicalin did not suppress IL-1beta-induced IL-6 and IL-8 production, but dexamethasone, baicalein, and wogonin, significantly suppressed IL-6 and IL-8 production. wogonin 103-110 interleukin 6 Homo sapiens 137-141 12925148-9 2003 Reb suppressed PGE1 -, but not 15d-PGJ2-, induced increase of IL-6 and IL-8 production. Alprostadil 15-19 interleukin 6 Homo sapiens 62-66 12876624-5 2003 The inhibition of fibrinogen synthesis by oxysterols was maintained in interleukin-6 treated cells. Oxysterols 42-52 interleukin 6 Homo sapiens 71-84 12637577-2 2003 Here we show unequivocally that the production of interleukin (IL)-1beta, IL-6, IL-10, and tumor necrosis factor alpha (TNFalpha) requires p38 MAPK activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha (SBR-p38alpha) that fails to bind to SB 203580. Antimony 205-207 interleukin 6 Homo sapiens 74-78 12637577-2 2003 Here we show unequivocally that the production of interleukin (IL)-1beta, IL-6, IL-10, and tumor necrosis factor alpha (TNFalpha) requires p38 MAPK activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha (SBR-p38alpha) that fails to bind to SB 203580. Antimony 249-251 interleukin 6 Homo sapiens 74-78 12640021-3 2003 Infusion with HiIL-6 and LoIL-6 resulted in a marked (P < 0.05) increase in systemic IL-6 concentration throughout the 3 h of infusion (mean arterial plasma [IL-6]s of 319 and 143 pg ml-1 for HiIL-6 and LoIL-6, respectively), followed by a rapid decline (P < 0.05) during the recovery period. loil 206-210 interleukin 6 Homo sapiens 16-20 12640021-3 2003 Infusion with HiIL-6 and LoIL-6 resulted in a marked (P < 0.05) increase in systemic IL-6 concentration throughout the 3 h of infusion (mean arterial plasma [IL-6]s of 319 and 143 pg ml-1 for HiIL-6 and LoIL-6, respectively), followed by a rapid decline (P < 0.05) during the recovery period. loil 206-210 interleukin 6 Homo sapiens 27-31 12709682-6 2003 At the end of CPB, the mean IL-6 level in the control group was significantly higher than in the diltiazem group (p=0.015), and at 3 hours after CPB the difference was even greater (p=0.002). Diltiazem 97-106 interleukin 6 Homo sapiens 28-32 12709682-8 2003 CONCLUSIONS: Diltiazem inhibits the release of the pro-inflammatory cytokine IL-6, which is strong evidence for its anti-inflammatory effect. Diltiazem 13-22 interleukin 6 Homo sapiens 77-81 12712592-1 2003 In a previous study, a significant increase in serum interleukin-6 (IL-6) was apparent after an acute low-level mercury (Hg) exposure, achieved by removal of amalgam fillings (Loftenius et al., 1998). Mercury 112-119 interleukin 6 Homo sapiens 53-66 12712592-1 2003 In a previous study, a significant increase in serum interleukin-6 (IL-6) was apparent after an acute low-level mercury (Hg) exposure, achieved by removal of amalgam fillings (Loftenius et al., 1998). Mercury 112-119 interleukin 6 Homo sapiens 68-72 12619182-6 2003 In the alendronate treated group, statistically significant changes occurred in the levels of serum IL-1alpha and IL-6 after three months, and in IL-1beta, IL-6, IL-6r and TNF-alpha after six months (p < 0.05). Alendronate 7-18 interleukin 6 Homo sapiens 114-118 12619182-6 2003 In the alendronate treated group, statistically significant changes occurred in the levels of serum IL-1alpha and IL-6 after three months, and in IL-1beta, IL-6, IL-6r and TNF-alpha after six months (p < 0.05). Alendronate 7-18 interleukin 6 Homo sapiens 156-160 14686092-6 2003 However, it is clear that IL-6 production is activated by intracellular calcium levels, mitogen-activated protein kinases, reduced glycogen availability and other cytokines such as IL-1 beta. Glycogen 131-139 interleukin 6 Homo sapiens 26-30 14609022-8 2003 The IL-6 production is modulated by the glycogen content in muscles, and IL-6 thus works as an energy sensor. Glycogen 40-48 interleukin 6 Homo sapiens 4-8 12509497-9 2003 The pre-exercise muscle glycogen concentration tended to correlate with the arteriovenous IL-6 concentration difference at rest, and the postexercise glycogen concentration was inversely correlated with IL-6 release during the final 35 min of exercise. Glycogen 24-32 interleukin 6 Homo sapiens 90-94 12509497-9 2003 The pre-exercise muscle glycogen concentration tended to correlate with the arteriovenous IL-6 concentration difference at rest, and the postexercise glycogen concentration was inversely correlated with IL-6 release during the final 35 min of exercise. Glycogen 150-158 interleukin 6 Homo sapiens 203-207 12509497-12 2003 The observation of a relationship between IL-6 release and muscle glycogen store both at rest and after exercise suggests that IL-6 may act as a carbohydrate sensor. Glycogen 66-74 interleukin 6 Homo sapiens 42-46 12509497-12 2003 The observation of a relationship between IL-6 release and muscle glycogen store both at rest and after exercise suggests that IL-6 may act as a carbohydrate sensor. Glycogen 66-74 interleukin 6 Homo sapiens 127-131 12899535-1 2003 Calcitriol, the hormonal form of vitamin D, enhances the anticancer activity of the immune cytokine tumor necrosis factor, interleukin 1 and interleukin 6 in human breast and renal cell carcinoma cells without affecting the cytotoxic action of interferon-alpha or killer lymphocytes. Calcitriol 0-10 interleukin 6 Homo sapiens 141-154 12433058-4 2002 Inhibition of gamma-glutamylcysteine synthetase, the rate-limiting enzyme in the biosynthesis of GSH, by the action of L-buthionine-(S,R)-sulfoximine (BSO), potentiated LPS-induced IL-1beta, IL-6 and TNF-alpha production. l-buthionine sulfoximine 119-149 interleukin 6 Homo sapiens 191-195 12433058-4 2002 Inhibition of gamma-glutamylcysteine synthetase, the rate-limiting enzyme in the biosynthesis of GSH, by the action of L-buthionine-(S,R)-sulfoximine (BSO), potentiated LPS-induced IL-1beta, IL-6 and TNF-alpha production. Buthionine Sulfoximine 151-154 interleukin 6 Homo sapiens 191-195 12230110-3 2002 In this report, the effects of polychlorinated biphenyl (PCB) on the expression of cyclooxygenase-2 and pro-inflammatory cytokines such as interleukin-1beta (IL-1beta), IL-6 and tumor necrosis factor (TNF)-alpha in the human leukemic mast cell line were investigated. Polychlorinated Biphenyls 31-55 interleukin 6 Homo sapiens 169-173 12230110-3 2002 In this report, the effects of polychlorinated biphenyl (PCB) on the expression of cyclooxygenase-2 and pro-inflammatory cytokines such as interleukin-1beta (IL-1beta), IL-6 and tumor necrosis factor (TNF)-alpha in the human leukemic mast cell line were investigated. Polychlorinated Biphenyls 57-60 interleukin 6 Homo sapiens 169-173 12230110-4 2002 TNF-alpha and IL-1beta expressed their respective mRNA in the presence or absence of PCB, while cyclooxygenase-2 (COX-2) and IL-6 mRNA expression were highly induced by PCB after 2 h. Moreover, pre-treatment with the nuclear factor (NF)-kappaB pathway inhibitor, pyrrolidine dithiocarbamate, suppressed COX-2, TNF-alpha and IL-1beta induction and reduced the IL-6 mRNA levels induced by PCB. Polychlorinated Biphenyls 169-172 interleukin 6 Homo sapiens 125-129 12230110-4 2002 TNF-alpha and IL-1beta expressed their respective mRNA in the presence or absence of PCB, while cyclooxygenase-2 (COX-2) and IL-6 mRNA expression were highly induced by PCB after 2 h. Moreover, pre-treatment with the nuclear factor (NF)-kappaB pathway inhibitor, pyrrolidine dithiocarbamate, suppressed COX-2, TNF-alpha and IL-1beta induction and reduced the IL-6 mRNA levels induced by PCB. Polychlorinated Biphenyls 169-172 interleukin 6 Homo sapiens 359-363 12230110-4 2002 TNF-alpha and IL-1beta expressed their respective mRNA in the presence or absence of PCB, while cyclooxygenase-2 (COX-2) and IL-6 mRNA expression were highly induced by PCB after 2 h. Moreover, pre-treatment with the nuclear factor (NF)-kappaB pathway inhibitor, pyrrolidine dithiocarbamate, suppressed COX-2, TNF-alpha and IL-1beta induction and reduced the IL-6 mRNA levels induced by PCB. Polychlorinated Biphenyls 169-172 interleukin 6 Homo sapiens 125-129 12230110-4 2002 TNF-alpha and IL-1beta expressed their respective mRNA in the presence or absence of PCB, while cyclooxygenase-2 (COX-2) and IL-6 mRNA expression were highly induced by PCB after 2 h. Moreover, pre-treatment with the nuclear factor (NF)-kappaB pathway inhibitor, pyrrolidine dithiocarbamate, suppressed COX-2, TNF-alpha and IL-1beta induction and reduced the IL-6 mRNA levels induced by PCB. Polychlorinated Biphenyls 169-172 interleukin 6 Homo sapiens 359-363 12233876-4 2002 DHT exerts a suppressive effect on IL-1beta induced IL-6, macrophage-colony stimulating factor (CSF), and granulocyte-CSF production by synoviocytes. Dihydrotestosterone 0-3 interleukin 6 Homo sapiens 52-56 12208321-7 2002 A continuous fall in chemokine and interleukin-6 serum concentrations, within the non-pathological range, accompanied a delayed down-regulation of the oxidative burst and an increase in apoptosis of neutrophils up to 28 days after the last azithromycin dose. Azithromycin 240-252 interleukin 6 Homo sapiens 35-48 12100719-4 2002 Here we show that EtxB, but not the receptor non-binding mutant EtxB (G33D), triggers the release of interleukin (IL)-10, IL-6 and tumour necrosis factor-alpha (TNF-alpha) by human monocytes. etxb 18-22 interleukin 6 Homo sapiens 122-126 12119487-9 2002 CONCLUSION: This study suggests that MZB could suppress IL-6 release in vitro and thus may exert its efficacy on IgAN. mizoribine 37-40 interleukin 6 Homo sapiens 56-60 12160520-8 2002 Addition of PGJ2 had an inhibitory effect on IL-1, IL-6 and TNFalpha secretion, while increasing IL-1Ra production. 9-deoxy-delta-9-prostaglandin D2 12-16 interleukin 6 Homo sapiens 51-55 12016129-9 2002 MAPK inhibitors (SB-203580, PD-98059, and U-0126) significantly reduced the IL-17-induced IL-6 and chemokine secretion. U 0126 42-48 interleukin 6 Homo sapiens 90-94 12020130-8 2002 In the presence of PKC inhibitor, the IL-6-mediated increase in permeability was attenuated (18-h TEER 73% of control with IL-6 exposure vs 95% of control with IL-6 + Go6976 inhibitor, P < 0.01). Go 6976 167-173 interleukin 6 Homo sapiens 38-42 12066846-8 2002 Thus ranking of the three, on the basis of the suppressive effect obtained, is IL12 > nitrite > IL6. Nitrites 89-96 interleukin 6 Homo sapiens 102-105 11959895-8 2002 RESULTS: Levels of IL-6 mRNA and protein increased in all cells treated with follicle-stimulating hormone (FSH), luteinizing hormone (LH), 17beta-estradiol, or estrone but increased only in OVCA cells treated with testosterone and 5alpha-dihydrotestosterone. Dihydrotestosterone 231-257 interleukin 6 Homo sapiens 19-23 12144121-9 2002 DISCUSSION: Our results clearly show that that idiosyncratic reaction observed in colorectal cancer patients after oxaliplatin infusion may be due to a massive release of cytokines such as TNF-alpha and IL-6. Oxaliplatin 115-126 interleukin 6 Homo sapiens 203-207 12498381-5 2002 The primary function of the additional IL-6 may be to regulate the supply of carbohydrate as muscle reserves of glycogen become depleted. Glycogen 112-120 interleukin 6 Homo sapiens 39-43 11746782-9 2002 Interleukin-6 release was increased at 10(-7) M of MeHgCl, whereas it was decreased when each of these two cell types was cultured separately. methylmercuric chloride 51-57 interleukin 6 Homo sapiens 0-13 11746782-10 2002 Moreover, addition of IL-6 to three-dimensional brain cell cultures treated with 3 x 10(-7) M of MeHgCl prevented the decrease in immunostaining of the neuronal markers MAP-2 and neurofilament-M. IL-6 administered to three-dimensional cultures in the absence of MeHgCl caused astrogliosis, as indicated by increased GFAP immunoreactivity. methylmercuric chloride 97-103 interleukin 6 Homo sapiens 22-26 11746782-10 2002 Moreover, addition of IL-6 to three-dimensional brain cell cultures treated with 3 x 10(-7) M of MeHgCl prevented the decrease in immunostaining of the neuronal markers MAP-2 and neurofilament-M. IL-6 administered to three-dimensional cultures in the absence of MeHgCl caused astrogliosis, as indicated by increased GFAP immunoreactivity. methylmercuric chloride 97-103 interleukin 6 Homo sapiens 196-200 11746782-10 2002 Moreover, addition of IL-6 to three-dimensional brain cell cultures treated with 3 x 10(-7) M of MeHgCl prevented the decrease in immunostaining of the neuronal markers MAP-2 and neurofilament-M. IL-6 administered to three-dimensional cultures in the absence of MeHgCl caused astrogliosis, as indicated by increased GFAP immunoreactivity. methylmercuric chloride 262-268 interleukin 6 Homo sapiens 22-26 11731593-0 2001 Interleukin-6 production in contracting human skeletal muscle is influenced by pre-exercise muscle glycogen content. Glycogen 99-107 interleukin 6 Homo sapiens 0-13 11731593-3 2001 This study tests the hypothesis that the exercise-induced IL-6 release from contracting muscle is linked to the intramuscular glycogen availability. Glycogen 126-134 interleukin 6 Homo sapiens 58-62 11731593-10 2001 Intramuscular IL-6 mRNA levels increased with exercise in both legs, but this increase was augmented in the leg having the lowest glycogen content at end-ex. Glycogen 130-138 interleukin 6 Homo sapiens 14-18 11731593-15 2001 This study demonstrates that glycogen availability is associated with alterations in the rate of IL-6 production and release in contracting skeletal muscle. Glycogen 29-37 interleukin 6 Homo sapiens 97-101 11785890-8 2001 Both in vitro and in vivo TAst-OSU challenge resulted in reduced interleukin (IL)-1 and IL-6 activity. osu 31-34 interleukin 6 Homo sapiens 88-92 11518271-14 2001 Hydroxyapatite particles yielded a 30-fold increase in interleukin-6 secretion compared to unstimulated controls, which was also greater than three times the levels produced by cobalt chromium, titanium, or HA/TCP. cobalt chromium 177-192 interleukin 6 Homo sapiens 55-68 11473728-0 2001 Enhancement of in vivo antitumor activity of a novel antimitotic 1-phenylpropenone derivative, AM-132, by tumor necrosis factor-alpha or interleukin-6. AM-132 95-101 interleukin 6 Homo sapiens 137-150 11473728-9 2001 LLC tumors expressing tumor necrosis factor-alpha (TNF-alpha), granulocyte macrophage colony-stimulating factor (GM-CSF), or interleukin (IL)-6 were very sensitive to AM-132. AM-132 167-173 interleukin 6 Homo sapiens 125-143 11473728-10 2001 In particular, LLC tumors expressing IL-6 were markedly reduced by AM-132 treatment, and showed coloring of the tumor surface and unusual hemorrhagic necrosis. AM-132 67-73 interleukin 6 Homo sapiens 37-41 11320084-8 2001 Treatment of HeLa cells with 2 mm l-buthionine sulfoximine promoted the formation of ox-HSF1 and blocked the heat-induced activation of HSF DNA binding activity. Buthionine Sulfoximine 34-58 interleukin 6 Homo sapiens 88-91 11337199-5 2001 Many of the behavioural changes seen in depression are simulated by three pro-inflammatory cytokines (IL-1, IL-6 and TNF-alpha), which may produce their impact on the brain by activating cyclooxygenase, nitric acid synthase and corticotrophin releasing factor. Nitric Acid 203-214 interleukin 6 Homo sapiens 108-112 11322786-4 2001 IL-6-induced activation of signal transducer and activator of transcription 3 (STAT3) was augmented by AR in the presence of dihydrotestosterone (DHT). Dihydrotestosterone 125-144 interleukin 6 Homo sapiens 0-4 11322786-4 2001 IL-6-induced activation of signal transducer and activator of transcription 3 (STAT3) was augmented by AR in the presence of dihydrotestosterone (DHT). Dihydrotestosterone 146-149 interleukin 6 Homo sapiens 0-4 11322786-5 2001 In addition, DHT treatment augmented endogenous STAT3-mediated gene expression by IL-6. Dihydrotestosterone 13-16 interleukin 6 Homo sapiens 82-86 11322786-6 2001 Conversely, DHT-induced AR activity was increased by IL-6, and a dominant negative form of STAT3 inhibited AR activation. Dihydrotestosterone 12-15 interleukin 6 Homo sapiens 53-57 11238657-6 2001 Histamine-induced beta-glucuronidase and IL-6 release and [Ca(2+)](i) elevation were inhibited by the selective H(1) antagonist fexofenadine (10(-7)-10(-4) M), but not by the H(2) antagonist ranitidine. Ranitidine 191-201 interleukin 6 Homo sapiens 41-45 11231289-3 2001 Pharmacologic inhibition of either the ERK or the p38 MAPK pathway, using U0126 and SB203580, respectively, reduced interleukin-6 protein induction by at least 70%, and combined inhibition of both pathways fully blocked interleukin-6 protein expression and reduced interleukin-6 mRNA induction by more than 80%. U 0126 74-79 interleukin 6 Homo sapiens 116-129 11181934-3 2001 Buthionine sulfoximine, an irreversible inhibitor of gamma-glutamylcysteine synthetase, the rate-limiting enzyme in glutathione (GSH) biosynthesis, induced intracellular reactive oxygen species (ROS) and the release of interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha. Buthionine Sulfoximine 0-22 interleukin 6 Homo sapiens 249-286 11053033-3 2000 Triptolide, with an IC(50) of approximately 20-50 ng/ml, inhibits normal and transformed human bronchial epithelial cell expression of interleukin (IL)-6 and IL-8 stimulated by phorbol 12-myristate 13-acetate (PMA), tumor necrosis factor-alpha, or IL-1 beta. triptolide 0-10 interleukin 6 Homo sapiens 135-153 11039672-4 2000 Although growth was stimulated in KMS-12-BM by interleukin-6 and interferon-alpha, it was inhibited in KMS-12-PE. kms-12-bm 34-43 interleukin 6 Homo sapiens 47-60 10915090-0 2000 Strong association of interleukin-6 and lipopolysaccharide-binding protein with severity of adverse reactions after diethylcarbamazine treatment of microfilaremic patients. Diethylcarbamazine 116-134 interleukin 6 Homo sapiens 22-35 10899931-11 2000 OSM-induced IL-6 mRNA and protein expression is inhibited by the mitogen-activated protein kinase (MAPK) inhibitors U0126 and SB202190, suggesting a requirement for the MAPKs ERK1/2 and p38 in this response. U 0126 116-121 interleukin 6 Homo sapiens 12-16 11147963-11 2000 Binding of the heat shock factor (HSF) to the heat shock element (HSE) in the presence of herbimycin A or delta12PGJ2, and the effects of DTT, mirrored the results of Hsp70 induction. Dithiothreitol 138-141 interleukin 6 Homo sapiens 15-32 11147963-11 2000 Binding of the heat shock factor (HSF) to the heat shock element (HSE) in the presence of herbimycin A or delta12PGJ2, and the effects of DTT, mirrored the results of Hsp70 induction. Dithiothreitol 138-141 interleukin 6 Homo sapiens 34-37 10636920-1 2000 The role of signal transducer and activator of transcription (STAT) signaling pathways in the interleukin-6 (IL-6)-induced morphological differentiation of PC12-E2 cells was assessed using wild type and dominant negative mutants of Stat1 and Stat3, containing Tyr --> Phe (YF), Ser --> Ala (SA), and the double mutations (DM), respectively. Phenylalanine 271-274 interleukin 6 Homo sapiens 94-107 10636920-1 2000 The role of signal transducer and activator of transcription (STAT) signaling pathways in the interleukin-6 (IL-6)-induced morphological differentiation of PC12-E2 cells was assessed using wild type and dominant negative mutants of Stat1 and Stat3, containing Tyr --> Phe (YF), Ser --> Ala (SA), and the double mutations (DM), respectively. Phenylalanine 271-274 interleukin 6 Homo sapiens 109-113 11268391-4 2000 Exposure to IL-6 increases cortisol or corticosterone release from human, bovine, and rat adrenal cells. Corticosterone 39-53 interleukin 6 Homo sapiens 12-16 10774464-3 2000 Superantigens such as pyrogenic exotoxin A interact with monocytes and T lymphocytes in unique ways, resulting in T-cell proliferation and watershed production of monokines (e.g. tumor necrosis factor alpha, interleukin 1, interleukin 6), and lymphokines (e.g. tumor necrosis factor beta, interleukin 2, and gamma-interferon). pyrogenic exotoxin a 22-42 interleukin 6 Homo sapiens 223-236 11029783-6 2000 Our other studies have revealed that 5"-fluorouridine (5"-DFUR) inhibits the growth of KPL-4 tumors and decreases IL-6 levels in both serum and tumor tissues. doxifluridine 55-62 interleukin 6 Homo sapiens 114-118 11029783-8 2000 Docetaxel increased IL-6 levels in both serum and KPL-4 tumors, but combined treatment with docetaxel and 5"-DFUR resulted not only in a potent antitumor effect but also in a drastic decrease of serum IL-6 levels. doxifluridine 106-113 interleukin 6 Homo sapiens 201-205 10408408-9 1999 Up-regulation of IL-6 by n-sodium butyrate (n-BT) was studied in ESCC cell lines. n-bt 44-48 interleukin 6 Homo sapiens 17-21 10408408-15 1999 Although IL-6 was detected in some ESCC cell lines, IL-6 gene expression and protein production could be induced or enhanced by n-BT treatment in all three cell lines. n-bt 128-132 interleukin 6 Homo sapiens 52-56 10731102-5 1999 The ability of IL-6+IL-6sR to increase aromatase activity was only marginally reduced by the PG synthesis inhibitor, indomethacin, indicating that IL-6+IL-6sR does not appear to act via induction of PG synthesis. pg 93-95 interleukin 6 Homo sapiens 15-19 10397515-7 1999 RESULTS: In serum-free medium, T and DHT at concentrations of 5 x 10(-8) to 10(-7)M significantly (P <0.05) inhibited IL-6 production by hGF. Dihydrotestosterone 37-40 interleukin 6 Homo sapiens 121-125 10397515-10 1999 CONCLUSIONS: We concluded that elevated levels of androgens, specifically testosterone and dihydrotestosterone, could affect the stromal cell response to an inflammatory challenge by downregulation of IL-6 production. Dihydrotestosterone 91-110 interleukin 6 Homo sapiens 201-205 10360689-19 1999 Blocking RNA synthesis with actinomycin D or preventing protein synthesis with cycloheximide abolished or decreased particle-induced release of TNF-alpha and IL-6 from the macrophages. Cycloheximide 79-92 interleukin 6 Homo sapiens 158-162 9987074-7 1999 RESULTS: We found that calcitriol and paricalcitol behaved in a similar fashion, resulting in increased IL-6 release only at higher concentrations (10(-7) to 10(-9) M). Calcitriol 23-33 interleukin 6 Homo sapiens 104-108 9655919-3 1998 Cycloheximide (CHI) at 10 microg/ml, which inhibited protein synthesis for 80%, caused a 80-fold induction of IL-6 mRNA level which was due predominantly to a stabilization of IL-6 mRNA (20-fold) early on. Cycloheximide 0-13 interleukin 6 Homo sapiens 110-114 9655919-3 1998 Cycloheximide (CHI) at 10 microg/ml, which inhibited protein synthesis for 80%, caused a 80-fold induction of IL-6 mRNA level which was due predominantly to a stabilization of IL-6 mRNA (20-fold) early on. Cycloheximide 0-13 interleukin 6 Homo sapiens 176-180 9655919-3 1998 Cycloheximide (CHI) at 10 microg/ml, which inhibited protein synthesis for 80%, caused a 80-fold induction of IL-6 mRNA level which was due predominantly to a stabilization of IL-6 mRNA (20-fold) early on. Cycloheximide 15-18 interleukin 6 Homo sapiens 110-114 9655919-3 1998 Cycloheximide (CHI) at 10 microg/ml, which inhibited protein synthesis for 80%, caused a 80-fold induction of IL-6 mRNA level which was due predominantly to a stabilization of IL-6 mRNA (20-fold) early on. Cycloheximide 15-18 interleukin 6 Homo sapiens 176-180 9661009-3 1998 Trovafloxacin levels achievable in humans suppressed in vitro synthesis of each of the cytokines analyzed, viz., interleukin-1 alpha (IL-1 alpha), IL-1 beta, IL-6, IL-10, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor alpha. trovafloxacin 0-13 interleukin 6 Homo sapiens 158-162 10374431-14 1998 CONCLUSION: IL-6 functions as an autocrine growth stimulator for PG cells in vivo as well as in vitro. pg 65-67 interleukin 6 Homo sapiens 12-16 9616381-8 1998 Preincubation with cycloheximide inhibited IL-6 but not IL-8 transcription, and incubation of stimulated cells with actinomycin D stabilized IL-8 and also IL-6 mRNA. Cycloheximide 19-32 interleukin 6 Homo sapiens 43-47 9514534-9 1998 Endotoxin and interleukin-6 levels increased in a similar manner to nitrate levels, but tumor necrosis factor-alpha and interleukin-1 beta levels did not. Nitrates 68-75 interleukin 6 Homo sapiens 14-27 9510942-5 1998 The used stimulators-zymosan and lipopolysaccharide (LPS) resulted in increased IL-6sR secretion by PMNs and WBC of patients but did not influence IL-6 production by the same cells. Zymosan 21-28 interleukin 6 Homo sapiens 80-84 9469590-9 1998 The pulse-chase study showed that addition of N-acetyl leucyl leucyl norleucinal to the medium induced a decrease in newly synthesized apoB in the cell lysate in response to IL-1beta (P < 0.05) or IL-6 (not to a significant extent) compared with control. n-acetyl leucyl leucyl 46-68 interleukin 6 Homo sapiens 200-204 9391003-8 1997 A similar mechanism may play a role in the blunted ACTH response and elevated corticosterone levels under pathophysiological conditions observed in humans with high brain levels of IL-6. Corticosterone 78-92 interleukin 6 Homo sapiens 181-185 9412820-7 1997 In addition, both PGE1 and SM-6 increased production of TGF-beta 1, IL-8 and IL-6 and levels of cAMP in both cell types. Alprostadil 18-22 interleukin 6 Homo sapiens 77-81 9348243-5 1997 DHT, at increasing doses up to 10(-8) M, resulted in a release of IL-6 from LNCaP cells. Dihydrotestosterone 0-3 interleukin 6 Homo sapiens 66-70 9348243-6 1997 This dose-dependent effect of DHT on LNCaP proliferation could be partially inhibited by the addition of antibody against IL-6 into the culture medium. Dihydrotestosterone 30-33 interleukin 6 Homo sapiens 122-126 9348243-7 1997 These results indicate that the DHT-induced expression of IL-6 stimulates proliferation of LNCaP cells in culture in an autocrine manner. Dihydrotestosterone 32-35 interleukin 6 Homo sapiens 58-62 9359399-11 1997 This rapid turnover of the osmotic-stress-induced HSF-binding activity was inhibited by cycloheximide, a potent inhibitor of protein synthesis. Cycloheximide 88-101 interleukin 6 Homo sapiens 50-53 10072866-12 1997 CONCLUSION: These results indicate that IL-6 can function as an autocrine stimulator for PG cells in vivo as well as in vitro. pg 89-91 interleukin 6 Homo sapiens 40-44 9210006-0 1997 In vitro effects of lithium chloride on TNF alpha and IL-6 production by monocytes from breast cancer patients. Lithium Chloride 20-36 interleukin 6 Homo sapiens 54-58 9210006-2 1997 In this study we have evaluated the in vitro effect of LiCl on TNF alpha and interleukin-6 (IL-6) release by monocytes from patients affected by non-metastatic (BCa/M0) and metastatic breast cancer (BCa/M1), preincubated with autologous serum (sPt). Lithium Chloride 55-59 interleukin 6 Homo sapiens 77-90 9210006-2 1997 In this study we have evaluated the in vitro effect of LiCl on TNF alpha and interleukin-6 (IL-6) release by monocytes from patients affected by non-metastatic (BCa/M0) and metastatic breast cancer (BCa/M1), preincubated with autologous serum (sPt). Lithium Chloride 55-59 interleukin 6 Homo sapiens 92-96 9210006-6 1997 Moreover, the results obtained from the same cells, preincubated in sPt and treated with LiCl, indicate that serum factors may synergize with LiCl treatment in releasing IL-6. Lithium Chloride 89-93 interleukin 6 Homo sapiens 170-174 9210006-6 1997 Moreover, the results obtained from the same cells, preincubated in sPt and treated with LiCl, indicate that serum factors may synergize with LiCl treatment in releasing IL-6. Lithium Chloride 142-146 interleukin 6 Homo sapiens 170-174 9144567-3 1997 Furthermore, IL-6 mRNA accumulation stimulated by cycloheximide or anisomycin is almost completely inhibited in the presence of actinomycin D, indicating that this effect occurs mainly through the activation of the transcriptional machinery. Cycloheximide 50-63 interleukin 6 Homo sapiens 13-17 9089795-7 1997 In vitro IL-6 production was stimulated by PGE2 in alloactivated cultures and by iloprost, whatever the stimulus. Iloprost 81-89 interleukin 6 Homo sapiens 9-13 9071565-4 1997 Serum nitrate levels correlated significantly with both pro-inflammatory cytokines (IL-6, IL-8, TNF-alpha) as well as anti-inflammatory cytokines (IL-10, TNFsrI, TNFsrII). Nitrates 6-13 interleukin 6 Homo sapiens 84-88 9179627-8 1997 The temporal expression of TNF, IL-1, IL-6 and NO suggest a cascade of inflammatory mediators in which monocytes and macrophages respond to PG/PS with enhanced synthesis of TNF and IL-1, which may in turn promote the synthesis of IL-6 and NO. pg 140-142 interleukin 6 Homo sapiens 38-42 9179627-8 1997 The temporal expression of TNF, IL-1, IL-6 and NO suggest a cascade of inflammatory mediators in which monocytes and macrophages respond to PG/PS with enhanced synthesis of TNF and IL-1, which may in turn promote the synthesis of IL-6 and NO. pg 140-142 interleukin 6 Homo sapiens 230-234 9003059-4 1997 PGE1 and PGE2, but not PGD2 and PGF2 alpha, led to a rapid and transient induction of IL-6 mRNA, followed by IL-6 protein synthesis. Alprostadil 0-4 interleukin 6 Homo sapiens 86-90 9003059-4 1997 PGE1 and PGE2, but not PGD2 and PGF2 alpha, led to a rapid and transient induction of IL-6 mRNA, followed by IL-6 protein synthesis. Alprostadil 0-4 interleukin 6 Homo sapiens 109-113 10072840-8 1997 Treatment of PG cells with anti-IL-6 antibodies resulted in reduced growth of PG cells. pg 13-15 interleukin 6 Homo sapiens 32-36 10072840-9 1997 CONCLUSION: The results indicate that IL-6 behaves as an autocrine growth stimulator for PG cells in vitro. pg 89-91 interleukin 6 Homo sapiens 38-42 8977259-0 1996 Myeloma cell growth arrest, apoptosis, and interleukin-6 receptor modulation induced by EB1089, a vitamin D3 derivative, alone or in association with dexamethasone. Cholecalciferol 98-108 interleukin 6 Homo sapiens 43-56 9063027-2 1996 We studied IL-6 levels in 50 HCVAb+ patients with liver cirrhosis (grouped into A, B and C, Child classes) and in 27 healthy control subjects. hcvab 29-34 interleukin 6 Homo sapiens 11-15 8920958-4 1996 The maximal IL-6-induced increase in IGFBP-1 was comparable to that observed with dexamethasone, and this increase was attenuated by diltiazem or dantrolene, both of which are known to reduce the cytosolic Ca2+ concentration. Diltiazem 133-142 interleukin 6 Homo sapiens 12-16 8887280-3 1996 We examined the mechanism of IL-6 secretion by HPMC exposed to the milicu present in the peritoneal cavity during the initiation of inflammation. Hypromellose Derivatives 47-51 interleukin 6 Homo sapiens 29-33 8887280-4 1996 Exposure of HPMC to spent peritoneal dialysis effluent (PDE) or IL-1 beta resulted in a time- and dose-dependent increase in IL-6 secretion. Hypromellose Derivatives 12-16 interleukin 6 Homo sapiens 125-129 8784206-8 1996 At variance from the native species, mutant IL-6 in the A-state binds 1-anilinonaphthalene-8-sulfonic acid (ANS), a property considered most typical of a protein in the molten globule state. 1-anilino-8-naphthalenesulfonate 70-106 interleukin 6 Homo sapiens 44-48 8784206-8 1996 At variance from the native species, mutant IL-6 in the A-state binds 1-anilinonaphthalene-8-sulfonic acid (ANS), a property considered most typical of a protein in the molten globule state. 1-anilino-8-naphthalenesulfonate 108-111 interleukin 6 Homo sapiens 44-48 8768854-9 1996 Exacerbation of thyrotoxicosis with markedly increased IL-6 was controlled by prednisone in 3 of 4 cases. Prednisone 78-88 interleukin 6 Homo sapiens 55-59 8674325-8 1996 Children with increased plasma IL-6 concentrations (n = 6) had increased plasma nitrite/nitrate concentrations (p < 0.01 on each day), increased organ failure scores (p < .05 on days 1 and 3), and the highest plasma IL-10 concentrations (p < .05 on days 1 and 3, p = .054 on day 2) when compared with children with sepsis and undetectable IL-6 concentrations. Nitrites 80-87 interleukin 6 Homo sapiens 31-35 8674325-8 1996 Children with increased plasma IL-6 concentrations (n = 6) had increased plasma nitrite/nitrate concentrations (p < 0.01 on each day), increased organ failure scores (p < .05 on days 1 and 3), and the highest plasma IL-10 concentrations (p < .05 on days 1 and 3, p = .054 on day 2) when compared with children with sepsis and undetectable IL-6 concentrations. Nitrates 88-95 interleukin 6 Homo sapiens 31-35 8674325-9 1996 Children with sepsis and detectable IL-6 concentrations, and children with undetectable IL-6 concentrations, both had increased nitrite/nitrate concentrations (p < .005 on days 1 through 3) and increased IL-10 concentrations (p < .05 on days 1 and 2) compared with controls. Nitrites 128-135 interleukin 6 Homo sapiens 88-92 8674325-9 1996 Children with sepsis and detectable IL-6 concentrations, and children with undetectable IL-6 concentrations, both had increased nitrite/nitrate concentrations (p < .005 on days 1 through 3) and increased IL-10 concentrations (p < .05 on days 1 and 2) compared with controls. Nitrates 136-143 interleukin 6 Homo sapiens 88-92 8782901-6 1996 Among the various cytokines investigated such as interleukin-1, interleukin-6, tumor necrosis factor-alpha and interferon-gamma (IFN-gamma), only IFN-gamma markedly enhanced A beta-dependent nitrite production. Nitrites 191-198 interleukin 6 Homo sapiens 64-106 8608653-4 1996 IL-6 production by the TCL from synovial membrane or from patients" PBMC was also significantly higher than that from healthy donors" PBMC. Triclosan 23-26 interleukin 6 Homo sapiens 0-4 8743284-2 1996 and intracerebroventricular (i.c.v) administration of increasing doses of recombinant human IL-1 beta, TNF alpha and IL-6 on plasma corticosterone (B) levels in rats. Corticosterone 132-146 interleukin 6 Homo sapiens 117-121 8704096-1 1996 We evaluate the influence of IL-4, IL-10 and TGF-beta upon the release of IL-1 alpha, tumor necrosis factor-alpha (TNF-alpha), and IL-6 by lipopolisaccharide (LPS, 1 microgram/ml) stimulated alveolar macrophages (AM). lipopolisaccharide 139-157 interleukin 6 Homo sapiens 131-135 8564798-10 1995 During this same period of time, PGE1, but not 1,25(OH)2D3, markedly stimulated cellular elaboration of interleukin (IL)-1 alpha, IL-6, and tumor necrosis factor (TNF)-alpha, and 1,25(OH)2D3 cotreatment strongly augmented these effects. Alprostadil 33-37 interleukin 6 Homo sapiens 130-134 7473176-0 1995 Effects of methylprednisolone and 21-aminosteroids on mitogen-induced interleukin-6 and tumor necrosis factor-alpha production in human peripheral blood mononuclear cells. 21-aminosteroids 34-50 interleukin 6 Homo sapiens 70-115 8528601-0 1995 Pharmacological modulation of IL-6 and IL-8 secretion by the H1-antagonist decarboethoxy-loratadine and dexamethasone by human mast and basophilic cell lines. decarboethoxy-loratadine 75-99 interleukin 6 Homo sapiens 30-34 7629516-7 1995 We found that submicromolar concentrations of C2-ceramide induced IL-6 gene expression and protein production as effectively as IL-1 beta. N-acetylsphingosine 46-57 interleukin 6 Homo sapiens 66-70 7629516-8 1995 Both D-erythro-C2-ceramide (a cell-permeable analogue of natural ceramide) and D-threo-C2-ceramide were potent inducers of IL-6 production, while neither L isomer of ceramide was effective. N-acetylsphingosine 5-26 interleukin 6 Homo sapiens 123-127 7769130-5 1995 In addition, testosterone, dihydrotestosterone, and adrenal androgens inhibited the expression of a chloramphenicol acetyl transferase reporter plasmid driven by the human IL-6 promoter in HeLa cells cotransfected with an androgen receptor expression plasmid; however, these steroids were ineffective when the cells were cotransfected with an estrogen receptor expression plasmid. Dihydrotestosterone 27-46 interleukin 6 Homo sapiens 172-176 7763252-2 1995 Among those tested, erythromycin (EM) and clarithromycin (CAM) uniquely suppressed mRNA levels as well as the release of IL-6 at the therapeutic and non-cytotoxic concentration (10(-6)M). Clarithromycin 42-56 interleukin 6 Homo sapiens 121-125 7640347-0 1995 Interleukin 6 production by lipopolysaccharide-stimulated human fibroblasts is potently inhibited by naphthoquinone (vitamin K) compounds. Vitamin K 117-126 interleukin 6 Homo sapiens 0-13 7851440-3 1995 Mutant interleukin-6 was solubilized in 6 M guanidine hydrochloride, subjected to oxidative refolding and purified to homogeneity by ammonium sulfate precipitation and hydrophobic chromatography. Guanidine 44-67 interleukin 6 Homo sapiens 7-20 8068947-10 1994 JPX-9 accumulated steady state transcripts of the endogenous IL-6 gene in response to the induction of Tax expression. jpx-9 0-5 interleukin 6 Homo sapiens 61-65 7951851-4 1994 Serum IL-6 levels correlated closely with serum IL-8 levels and with serum carbohydrate antigen (CA) 19-9 levels. carbohydrate antigen 75-95 interleukin 6 Homo sapiens 6-10 8004813-4 1994 In contrast, IL-10 was weakly expressed when fibroblasts were stimulated with LPS, IL-1 alpha or tumour necrosis factor-alpha (TNF-alpha), but the expression was enhanced in the presence of cycloheximide combined with optimal concentrations of LPS, IL-1 alpha or TNF-alpha, IL-1 alpha was a more potent stimulator than LPS for GM-CSF, IL-6, IL-8 and IL-10 expression, but not for IL-1 alpha and IL-1 beta. Cycloheximide 190-203 interleukin 6 Homo sapiens 335-339 8167153-3 1994 Inhibition of the response to IL-6 by cycloheximide and alpha-amanitin indicates that increases in PAI-1 are dependent on both protein and RNA synthesis. Cycloheximide 38-51 interleukin 6 Homo sapiens 30-34 7511596-10 1994 Cimetidine and ranitidine, H2 receptor antagonists structurally unrelated to each other, completely reversed the histamine-mediated increase in IL-1 alpha-induced IL-6 synthesis. Ranitidine 15-25 interleukin 6 Homo sapiens 163-167 7914751-5 1994 Addition of exogenous AZA, 6-mercaptopurine (6-MP), and MTX to the IL-6 bioassay resulted in a dose-dependent inhibition of the B9 cell proliferation induced by IL-6, AZA being most potent on a molar basis. Mercaptopurine 27-43 interleukin 6 Homo sapiens 67-71 7914751-5 1994 Addition of exogenous AZA, 6-mercaptopurine (6-MP), and MTX to the IL-6 bioassay resulted in a dose-dependent inhibition of the B9 cell proliferation induced by IL-6, AZA being most potent on a molar basis. Mercaptopurine 27-43 interleukin 6 Homo sapiens 161-165 7914751-5 1994 Addition of exogenous AZA, 6-mercaptopurine (6-MP), and MTX to the IL-6 bioassay resulted in a dose-dependent inhibition of the B9 cell proliferation induced by IL-6, AZA being most potent on a molar basis. Mercaptopurine 45-49 interleukin 6 Homo sapiens 67-71 7914751-5 1994 Addition of exogenous AZA, 6-mercaptopurine (6-MP), and MTX to the IL-6 bioassay resulted in a dose-dependent inhibition of the B9 cell proliferation induced by IL-6, AZA being most potent on a molar basis. Mercaptopurine 45-49 interleukin 6 Homo sapiens 161-165 8130044-12 1994 We conclude that anaesthesia with alfentanil and propofol diminished release of IL-6 in response to abdominal surgery compared with isoflurane and that this reduction was an effect of alfentanil. Alfentanil 34-44 interleukin 6 Homo sapiens 80-84 8130044-12 1994 We conclude that anaesthesia with alfentanil and propofol diminished release of IL-6 in response to abdominal surgery compared with isoflurane and that this reduction was an effect of alfentanil. Alfentanil 184-194 interleukin 6 Homo sapiens 80-84 7538432-8 1994 APP expression in H-35 and HepG2 cells, stimulated by interleukin 1 (IL-1), IL-6, and dexamethasone, was inhibited by diltiazem or verapamil but not SOD. Diltiazem 118-127 interleukin 6 Homo sapiens 76-80 8403509-3 1993 Given that fever is often a prominent feature of hypersensitivity, we also assessed whether SMX or SMX-HA could induce the in vitro production of IL-1 beta, IL-6 or tumour necrosis factor-alpha (TNF-alpha) by PBMC. Sulfamethoxazole 92-95 interleukin 6 Homo sapiens 157-161 8325885-4 1993 The p53 mutants Val-135 and Phe-132 up-regulated IL-6 promoter activity in these cells at both 32.5 and 37 degrees C. The temperature-sensitive Val-135 mutant was not only not inhibitory or "wt-like" at the lower temperature, but had gained a transcriptional activator phenotype which was temperature-independent in HeLa cells. Phenylalanine 28-31 interleukin 6 Homo sapiens 49-53 8325885-5 1993 The functional DNA target for transcriptional modulation of the IL-6 promoter by p53 species included the multiple cytokine- and second messenger-response element (-173 to -145); point mutations in the transcription factor C/EBP beta-binding site within the second messenger-response element largely blocked the ability of p53 mutants Val-135 and Phe-132 to up-regulate this promoter. Phenylalanine 347-350 interleukin 6 Homo sapiens 64-68 8325885-7 1993 In contrast, the p53 mutants Val-135 and Phe-132 further enhanced C/EBP beta-mediated up-regulation of IL-6 promoter constructs. Phenylalanine 41-44 interleukin 6 Homo sapiens 103-107 8476047-4 1993 Regenerating liver KC 12-120 h after PHx responded to LPS with a significantly greater (P < 0.05) production of IL-1 and IL-6 in standard RPMI 1640. rpmi 1640 141-150 interleukin 6 Homo sapiens 124-128 8476047-5 1993 This enhancement of regenerating liver KC to produce IL-1 and IL-6 was increased (P < 0.05) by placing these same KC in 10 microM arginine RPMI 1640 culture media. rpmi 1640 142-151 interleukin 6 Homo sapiens 62-66 8054703-6 1993 The potentiation of IL6 mRNA by TGF-beta 1 required de novo synthesis of an intermediate protein since treatment with cycloheximide abrogated the amount of mRNA enhanced by TGF-beta 1 without affecting IL1 alpha-driven mRNA production. Cycloheximide 118-131 interleukin 6 Homo sapiens 20-23 1337987-5 1992 1,25-(OH)2D3 dose-dependently inhibited the production of IL-alpha, IL-6 and TNF-alpha by Escherichia coli lipopolysaccharide (LPS)-stimulated monocytes, without affecting superoxide production. Calcitriol 0-12 interleukin 6 Homo sapiens 68-72 1400875-6 1992 Additionally, treatment of chorion cells with IL-1 beta in combination with actinomycin-D or cycloheximide attenuated the stimulatory action of IL-1 beta on IL-6 production. Cycloheximide 93-106 interleukin 6 Homo sapiens 157-161 1530617-4 1992 A protein synthesis inhibitor cycloheximide abolished the IL-6 release, suggesting a de novo synthesis. Cycloheximide 30-43 interleukin 6 Homo sapiens 58-62 1321736-8 1992 The reappearance of IL6-binding sites at the cell surface required greater than 8 h and was sensitive to cycloheximide, suggesting that gp80 is not recycled after internalization. Cycloheximide 105-118 interleukin 6 Homo sapiens 20-23 1610348-5 1992 When IL-1 alpha-induced fibroblasts were exposed to cycloheximide there was enhancement of the net de novo synthesis and secretion of IL-6 as followed by [35S]-methionine labeling ("superinduction") but the secreted cytokine was no longer phosphorylated as monitored by [32P] labeling. Cycloheximide 52-65 interleukin 6 Homo sapiens 134-138 1610348-7 1992 Furthermore, IL-6 phosphorylation is inhibited by cycloheximide through a mechanism different from the drug"s effects on polypeptide synthesis per se. Cycloheximide 50-63 interleukin 6 Homo sapiens 13-17 1319453-7 1992 IL-6 had no effect on message levels but did increase circulating ACTH and corticosterone levels both 4 h and 24 h after injection. Corticosterone 75-89 interleukin 6 Homo sapiens 0-4 1317349-6 1992 Up-regulation of TNF receptors by IL-6 is dependent on de novo protein synthesis since receptor induction is abolished in the presence of cycloheximide. Cycloheximide 138-151 interleukin 6 Homo sapiens 34-38 1730219-9 1992 The presence of the oligomannose structures and the mannose-terminating tetrasaccharide on IL-6 may be important in maintaining a high local concentration of the cytokine while limiting its systemic serum level via interaction with soluble mannose-binding serum lectins. mannose-terminating tetrasaccharide 52-87 interleukin 6 Homo sapiens 91-95 1294622-7 1992 Teicoplanin is a very strong inducer of TNF, IL-1 alpha and IL-6. Teicoplanin 0-11 interleukin 6 Homo sapiens 60-64 1937963-3 1991 Treatment of ACHN cells with rh IFN-gamma also leads to inhibition of proliferation of these cells in a dose-dependent manner, that can be reversed by exogenous rh IL-6, while IFN-alpha, IL-2, IL-4 and vinblastine or 17-beta-estradiol has no effect on growth (3H-thymidine uptake) of ACHN cells and IL-6 expression. 1,1'-Azobis(cyanocyclohexane) 13-17 interleukin 6 Homo sapiens 164-168 1937963-3 1991 Treatment of ACHN cells with rh IFN-gamma also leads to inhibition of proliferation of these cells in a dose-dependent manner, that can be reversed by exogenous rh IL-6, while IFN-alpha, IL-2, IL-4 and vinblastine or 17-beta-estradiol has no effect on growth (3H-thymidine uptake) of ACHN cells and IL-6 expression. 1,1'-Azobis(cyanocyclohexane) 13-17 interleukin 6 Homo sapiens 299-303 1761639-7 1991 Monocyte interleukin-6 downregulation by interleukin-4 is dose dependent and occurs whether Fc gamma RI cross-linking, muramyl dipeptide, indomethacin plus muramyl dipeptide, or interferon-gamma plus muramyl dipeptide is the interleukin-6 inducing stimulus. Acetylmuramyl-Alanyl-Isoglutamine 119-136 interleukin 6 Homo sapiens 9-22 1761639-7 1991 Monocyte interleukin-6 downregulation by interleukin-4 is dose dependent and occurs whether Fc gamma RI cross-linking, muramyl dipeptide, indomethacin plus muramyl dipeptide, or interferon-gamma plus muramyl dipeptide is the interleukin-6 inducing stimulus. Acetylmuramyl-Alanyl-Isoglutamine 156-173 interleukin 6 Homo sapiens 9-22 1761639-7 1991 Monocyte interleukin-6 downregulation by interleukin-4 is dose dependent and occurs whether Fc gamma RI cross-linking, muramyl dipeptide, indomethacin plus muramyl dipeptide, or interferon-gamma plus muramyl dipeptide is the interleukin-6 inducing stimulus. Acetylmuramyl-Alanyl-Isoglutamine 156-173 interleukin 6 Homo sapiens 9-22 1718855-3 1991 Although MH166 completely neutralized hIL-6 activity in vitro, treatment in vivo with hIL-6 and MH166 combined unexpectedly increased both anti-dinitrophenyl (DNP) and anti-sheep red blood cell (SRBC) antibody production more than treatment with IL-6 alone did. dinitrophenyl 144-157 interleukin 6 Homo sapiens 86-91 1885209-0 1991 Inhibition of production and function of interleukin-6 by 1,25-dihydroxyvitamin D3. Calcitriol 58-82 interleukin 6 Homo sapiens 41-54 1885209-3 1991 Hence, the ability of 1,25-(OH)2D3 to interfere with the production and function of IL-6 was investigated. Calcitriol 22-34 interleukin 6 Homo sapiens 84-88 1885209-4 1991 1,25-(OH)2D3 and the analogue MC 903 inhibited IL-6 production by LPS-stimulated human mononuclear cells. Calcitriol 0-12 interleukin 6 Homo sapiens 47-51 1885209-8 1991 Consistently, the production of IL-6 and IL-2 in rIL-1 driven thymocyte cultures were found to be reduced by 1,25-(OH)2D3. Calcitriol 109-121 interleukin 6 Homo sapiens 32-36 2040662-0 1991 Effect of recombinant human interleukin-6 on nitrite production of mouse myeloid leukemia cells. Nitrites 45-52 interleukin 6 Homo sapiens 28-41 2040662-1 1991 The effect of recombinant human interleukin-6 (rhIL-6) on induction of nitrite (NO(-2)) production was investigated in a mouse myeloid leukemia cell line (M1) and a subclone (Mm1). Nitrites 71-78 interleukin 6 Homo sapiens 32-45 2226778-7 1990 Stimulation of IL-6 transcripts in fibroblasts did also not require new protein synthesis as exposure to the protein synthesis inhibitor cycloheximide (CHX) enhanced accumulation of IL-6 mRNA in the presence or absence of TNF-alpha or LT. Cycloheximide 137-150 interleukin 6 Homo sapiens 15-19 2226778-7 1990 Stimulation of IL-6 transcripts in fibroblasts did also not require new protein synthesis as exposure to the protein synthesis inhibitor cycloheximide (CHX) enhanced accumulation of IL-6 mRNA in the presence or absence of TNF-alpha or LT. Cycloheximide 137-150 interleukin 6 Homo sapiens 182-186 2226778-7 1990 Stimulation of IL-6 transcripts in fibroblasts did also not require new protein synthesis as exposure to the protein synthesis inhibitor cycloheximide (CHX) enhanced accumulation of IL-6 mRNA in the presence or absence of TNF-alpha or LT. Cycloheximide 152-155 interleukin 6 Homo sapiens 15-19 2226778-7 1990 Stimulation of IL-6 transcripts in fibroblasts did also not require new protein synthesis as exposure to the protein synthesis inhibitor cycloheximide (CHX) enhanced accumulation of IL-6 mRNA in the presence or absence of TNF-alpha or LT. Cycloheximide 152-155 interleukin 6 Homo sapiens 182-186 2105658-0 1990 Interleukin 6 stimulates hepatic glucose release from prelabeled glycogen pools. Glycogen 65-73 interleukin 6 Homo sapiens 0-13 1690177-1 1990 We studied IL-6 gene expression in human monocytes stimulated by muramyl dipeptide (MDP), a synthetic immunomodulator derived from mycobacterial cell walls. Acetylmuramyl-Alanyl-Isoglutamine 84-87 interleukin 6 Homo sapiens 11-15 33824247-3 2020 TCS markedly downregulated IL-6, IL-8, and IL-15 in human periodontal ligament fibroblasts (HPDLFs) treated with LPS-PG. Triclosan 0-3 interleukin 6 Homo sapiens 27-31 34953240-8 2022 Moreover, the same order of potency (ME > EAE > HE) was observed also on peripheral blood mononuclear cells, in which the seed extracts were able to decrease TNF-alpha and IL-6 release after LPS-induced inflammation. Helium 48-50 interleukin 6 Homo sapiens 172-176 34636179-11 2021 Interleukin-6 (IL-6) and IL-8 production by stimulated ECs were unaltered by incubation with macrolides, whereas Clarithromycin exposure significantly decreased IL-6 gene expression. Clarithromycin 113-127 interleukin 6 Homo sapiens 161-165 34562102-10 2021 In addition, IL-1beta and TNF-alpha instead of IL-6 in osteoarthritic IPFP-derived FCM played key roles in cartilage degradation via activating p38MAPK rather than ERK1/2 signaling pathway. Fosfomycin 83-86 interleukin 6 Homo sapiens 47-51 34824594-10 2021 ES dose-dependently (12.5, 25, and 50 mg/L) decreased the production and mRNA levels of proinflammatory cytokines IL-1beta, IL-6, and TNF-alpha. Einsteinium 0-2 interleukin 6 Homo sapiens 124-128 34824594-12 2021 Conclusion: The results suggested that ES could selectively inhibit the activity of COX-2, and the anti-inflammatory effect of ES was associated with the inhibition of IL-1beta, IL-6, and TNF-alpha via negative regulation of MAPK and NF-kappaB signaling pathways in LPS-induced THP-1 cells. Einsteinium 39-41 interleukin 6 Homo sapiens 178-182 34824594-12 2021 Conclusion: The results suggested that ES could selectively inhibit the activity of COX-2, and the anti-inflammatory effect of ES was associated with the inhibition of IL-1beta, IL-6, and TNF-alpha via negative regulation of MAPK and NF-kappaB signaling pathways in LPS-induced THP-1 cells. Einsteinium 127-129 interleukin 6 Homo sapiens 178-182 34775465-8 2021 Sunitinib inhibited MamBo38HER2loss tumor growth in vivo and reduced stemness and IL6 production in vitro. Sunitinib 0-9 interleukin 6 Homo sapiens 82-85 34492283-8 2021 Furthermore, cell treatment with citric acid was found to reduce inflammation in a lipopolysaccharide (LPS)-induced in vitro inflammation model by significantly reducing interleukin 6 expression. Citric Acid 33-44 interleukin 6 Homo sapiens 170-183 34664926-0 2021 Photoelectrochemical IL-6 Immunoassay Manufactured on Multifunctional Catecholate-Modified TiO2 Scaffolds. catecholate(2-) 70-81 interleukin 6 Homo sapiens 21-25 34664926-5 2021 The catecholate-modified TiO2 photoelectrode is combined with a signal-off direct immunoassay to detect interleukin-6 (IL-6), a key biomarker for diagnosing and monitoring various diseases. catecholate(2-) 4-15 interleukin 6 Homo sapiens 104-117 34664926-5 2021 The catecholate-modified TiO2 photoelectrode is combined with a signal-off direct immunoassay to detect interleukin-6 (IL-6), a key biomarker for diagnosing and monitoring various diseases. catecholate(2-) 4-15 interleukin 6 Homo sapiens 119-123 34740538-11 2022 Also, L-carnitine supplementation has significantly reduced serum levels of IL-6 and FBS, which has also raised serum FC and Pediatrics Quality of Life scores compared with the placebo. Carnitine 6-17 interleukin 6 Homo sapiens 76-80 34740538-13 2022 CONCLUSION: Given the significant reductions in IL-6 and FBS levels, L-carnitine supplementation appeared to have some positive effects on the inflammation, blood glucose control, and prevention of cardiovascular events in these patients, as well as the improvement of quality of life. Carnitine 69-80 interleukin 6 Homo sapiens 48-52 34795863-6 2021 A subsequent functional assay using the MDA-MB-231 cell line demonstrated that the d-galactal-benzimidazole hybrid and the analogous galactoside derivative reduced the secretion of the proinflammatory cytokines interleukin-6 (IL-6) and IL-8 in a dose-dependent manner. d-galactal-benzimidazole 83-107 interleukin 6 Homo sapiens 211-224 34795863-6 2021 A subsequent functional assay using the MDA-MB-231 cell line demonstrated that the d-galactal-benzimidazole hybrid and the analogous galactoside derivative reduced the secretion of the proinflammatory cytokines interleukin-6 (IL-6) and IL-8 in a dose-dependent manner. d-galactal-benzimidazole 83-107 interleukin 6 Homo sapiens 226-230 34754315-10 2021 Molecular docking results showed that quercetin, luteolin, kaempferol, tanshinone IIa, wogonin, naringenin, nobiletin, dihydrotanshinlactone, beta-sitosterol, and salviolone have good affinity with core target proteins IL6, PTGS2, MAPK1, MAPK3, and CGRP1. wogonin 87-94 interleukin 6 Homo sapiens 219-222 34754325-11 2021 And it was found that IL6 was lowly expressed in the group with GlcN-treated MH7A cells, while DDIT3 was highly expressed. Glucosamine 64-68 interleukin 6 Homo sapiens 22-25 34831154-10 2021 Increased secretion of IL-6 and MIF was also observed upon the treatment of dermal fibroblasts with MGO, suggesting that MGO is sufficient for triggering these immunomodulatory responses. Pyruvaldehyde 100-103 interleukin 6 Homo sapiens 23-27 34831154-10 2021 Increased secretion of IL-6 and MIF was also observed upon the treatment of dermal fibroblasts with MGO, suggesting that MGO is sufficient for triggering these immunomodulatory responses. Pyruvaldehyde 121-124 interleukin 6 Homo sapiens 23-27 34842603-3 2021 Additionally, in vitro studies with normal human chondrocytes were conducted to investigate the effect of calcitriol on the expression of IL-33, IL-37, IL-6, TNF-alpha, TLRs, DAMPs, and MMPs. Calcitriol 106-116 interleukin 6 Homo sapiens 152-156 34492522-13 2021 IL-6 levels were lower in patients treated with colchicine (median 2.07 ng/L) compared to placebo (median 2.59 ng/L), although this was not statistically significant (p = 0.076). Colchicine 48-58 interleukin 6 Homo sapiens 0-4 34302591-0 2021 Venlafaxine demonstrated anti-arthritic activity possibly through down regulation of TNF-alpha, IL-6, IL-1beta, and COX-2. Venlafaxine Hydrochloride 0-11 interleukin 6 Homo sapiens 96-100 34302591-9 2021 Upon PCR analysis venlafaxine remarkably turndown the mRNA expression of TNF-alpha, IL-6, IL-1beta, and COX-2. Venlafaxine Hydrochloride 18-29 interleukin 6 Homo sapiens 84-88 34686461-12 2022 Colchicine patients had numerically lower levels of pre-PCI cytokines: IL-1beta (p = 0.01), IL-6 (p = 0.02), IL-10 (p = 0.01), IFNgamma (p = 0.01), TNFalpha (p = 0.02) and WBC-count (p = 0.04). Colchicine 0-10 interleukin 6 Homo sapiens 92-96 34493195-7 2022 RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients. Luteolin 112-120 interleukin 6 Homo sapiens 251-254 34466065-9 2021 Dieckol also regulated the proliferative (cyclin D1), inflammatory (COX-2, IL-6, TNF-alpha, and NF-kappaB), and apoptotic (caspase-3, Bax, Bcl-2) markers in the MG-63 cells. dieckol 0-7 interleukin 6 Homo sapiens 75-79 34589667-9 2021 Increased circulating CORT levels are probably associated with the activation of the hypothalamus-pituitary-interrenal axis by the LPS and the endocrine actions of IL-6. Corticosterone 22-26 interleukin 6 Homo sapiens 164-168 34448990-10 2022 IL-6 is a marker of intracranial inflammation and plays a role in the pathophysiology of DCVS and DCI after SAH in preclinical animal models and clinical studies. dci 98-101 interleukin 6 Homo sapiens 0-4 34443939-5 2021 The resulting immunosensor showed a linear response to log of concentration in the working range of 10 to 500 pg/mL, and low limit of detection (LOD) of 5.1 pg/mL IL-6 in phosphate buffer saline. phosphate buffer saline 171-194 interleukin 6 Homo sapiens 163-167 34540066-0 2021 Total serum IL-6 and TNF-C levels in children with bronchopneumonia following treatment with methylprednisolone in combination with azithromycin. Azithromycin 132-144 interleukin 6 Homo sapiens 12-16 34540066-1 2021 OBJECTIVE: To analyze the expression levels of total serum interleukin (IL)-6 and tumor necrosis factor (TNF)-C in children with bronchopneumonia treated by methylprednisolone in combination with azithromycin. Azithromycin 196-208 interleukin 6 Homo sapiens 59-77 34074584-7 2021 We verify that IL-6 (0.35; 95% CI: 0.13 to 0.56; z = 3.24; p = 0.001; d = 1.14) and IL-10 (9.06; 95% CI 0.41 to 17.70; z = 2.05; p = 0.04; d = 1.12) increases post-PE in CAF group versus PLA group. Caffeine 170-173 interleukin 6 Homo sapiens 15-19 34214498-7 2021 SARS-CoV-2-infected cells treated with famotidine demonstrate reduced expression levels of the inflammatory mediators CCL-2 and IL6, drivers of the cytokine release syndrome that precipitates poor outcome for patients with COVID-19. Famotidine 39-49 interleukin 6 Homo sapiens 128-131 34355287-8 2021 Moreover, BDMC-A treatment downregulated MMP-9, VEGF, TGF- beta, IL-6 and IL-8 and upregulated TIMP-2 levels. bdmc-a 10-16 interleukin 6 Homo sapiens 65-69 34326122-3 2021 Experimental use of colchicine resulted in an 85% decrease in C reactive protein levels 3 days after treatment initiation and a 182.6% decrease in interleukin-6 levels 8 days after treatment initiation. Colchicine 20-30 interleukin 6 Homo sapiens 147-160 34371919-6 2021 We showed that although TNF-alpha secretion was downregulated in both LPS-activated MPhi subtypes by caffeine, the secretion of IL-8, IL-6, and IL-1beta as well as the expression of Nod-like receptors was enhanced in M-MPhis, while it did not change in GM-MPhis. Caffeine 101-109 interleukin 6 Homo sapiens 134-138 34126960-2 2021 We aimed to assess if 25-hydroxyvitamin-D (25OHD) levels are associated with interleukin 6 (IL-6) levels and with disease severity and mortality in COVID-19. 25-hydroxyvitamin 22-39 interleukin 6 Homo sapiens 77-90 34126960-2 2021 We aimed to assess if 25-hydroxyvitamin-D (25OHD) levels are associated with interleukin 6 (IL-6) levels and with disease severity and mortality in COVID-19. 25-hydroxyvitamin 22-39 interleukin 6 Homo sapiens 92-96 34109109-0 2021 Effect of 1alpha,25-Dihydroxyvitamin D3 on the Radiation Response in Prostate Cancer: Association With IL-6 Signaling. Calcitriol 10-39 interleukin 6 Homo sapiens 103-107 34109109-2 2021 This study investigated the role of IL-6 in biological sequelae following irradiation and highlighted the effects of 1alpha,25-dihydroxyvitamin D3 (calcitriol) on the radiation response of PCa and its relationship with IL-6 signaling. Calcitriol 117-146 interleukin 6 Homo sapiens 219-223 34109109-2 2021 This study investigated the role of IL-6 in biological sequelae following irradiation and highlighted the effects of 1alpha,25-dihydroxyvitamin D3 (calcitriol) on the radiation response of PCa and its relationship with IL-6 signaling. Calcitriol 148-158 interleukin 6 Homo sapiens 219-223 34109109-5 2021 We also investigated the changes in radiation response after calcitriol supplementation and the relationship between calcitriol and IL-6 signaling by conducting cellular and animal experiments. Calcitriol 117-127 interleukin 6 Homo sapiens 132-136 34109109-8 2021 Moreover, increased vitamin D3 levels by calcitriol supplementation or induction by UVB-radiation was associated with inhibited IL-6 signaling and increased the response to irradiation observed in animal models. Cholecalciferol 20-30 interleukin 6 Homo sapiens 128-132 34109109-8 2021 Moreover, increased vitamin D3 levels by calcitriol supplementation or induction by UVB-radiation was associated with inhibited IL-6 signaling and increased the response to irradiation observed in animal models. Calcitriol 41-51 interleukin 6 Homo sapiens 128-132 35266250-9 2022 The fucoxanthin effectively inhibited the PI3K/Akt/mTOR cascade along with the expression of TNF-alpha, NF-kappaB, Cox-2, and IL-6 and antiapoptotic genes cyclin D1 and Bcl-2 in the HEC-1A cells. fucoxanthin 4-15 interleukin 6 Homo sapiens 126-130 35612681-1 2022 This study aimed to evaluate the separately effects of bioflavonoids proanthocyanidins, from grape seed extract (GSE) and synthetic naringenin (NA), as well as photobiomodulation (PBM) by low-level laser therapy on interleukin (IL)-6 and matrix metalloproteinases (MMPs) syntheses by human gingival fibroblasts (HGF). Proanthocyanidins 69-86 interleukin 6 Homo sapiens 215-233 35286922-1 2022 We have recently highlighting the role of spiroisoxazoline arteannuin B derivatives in mediating proinflammatory cytokines like IL-6, TNfalpha and NO in vitro. spiroisoxazoline 42-58 interleukin 6 Homo sapiens 128-132 35470916-8 2022 Finally, despite the increased inflammatory markers (IL-6 and TNF-alpha) in the placebo group, crocin treatment had protective effects on their increased changes. crocin 95-101 interleukin 6 Homo sapiens 53-57 35453606-10 2022 Gene expression analysis revealed high levels of IL6, MMP1 and CD68 expression after resiquimod application, and histological analysis showed increased immune cell infiltration. resiquimod 85-95 interleukin 6 Homo sapiens 49-52 35426800-7 2022 Treatment with TPL significantly decreased the expression of circRNA 0003353, suppressed the viability and migration ability, decreased the expressions of IL-6 and IL-17, and increased the expression IL-4 in cultured RA-FLS in a time-dependent manner (P < 0.01). triptolide 15-18 interleukin 6 Homo sapiens 155-159 35345256-7 2022 CONCLUSIONS: Exogenous phosphocreatine reduces stent implantation, triggers inflammation manifested as decreased serum levels of IL-6 and the aggregation of neutrophils, and protects the myocardium of the patients undergoing PCI. Phosphocreatine 23-38 interleukin 6 Homo sapiens 129-133 35246004-11 2022 Emodin treatment decreased the levels of TNF-alpha, IL-1beta, IL-6, NLRP3, SDC-1, GSDMD-N, and Caspase-1, while increasing the levels of IL-10 in LPS-treated 1321N1 cells. Emodin 0-6 interleukin 6 Homo sapiens 62-66 35265308-0 2022 Effect of Edaravone Combined with Anticoagulant Therapy on the Serum hs-CRP, IL-6, and TNF-alpha Levels and Activity of Daily Living in Patients with Acute Cerebral Infarction. Edaravone 10-19 interleukin 6 Homo sapiens 77-81 35265308-1 2022 Objective: To explore the effect of edaravone combined with anticoagulant therapy on the serum hs-CRP, IL-6, and TNF-alpha levels and the activity of daily living (ADL) in patients with acute cerebral infarction (ACI). Edaravone 36-45 interleukin 6 Homo sapiens 103-107 35138142-7 2022 Additionally, the Bz/AMD combination reduced (i) interleukin-6 (IL-6) levels in cardiac tissue, (ii) P-wave duration, and (iii) frequency of arrhythmia in infected animals and (iv) restored gap junction integrity in cardiac tissue. benzonidazole 18-20 interleukin 6 Homo sapiens 49-62 35138142-7 2022 Additionally, the Bz/AMD combination reduced (i) interleukin-6 (IL-6) levels in cardiac tissue, (ii) P-wave duration, and (iii) frequency of arrhythmia in infected animals and (iv) restored gap junction integrity in cardiac tissue. benzonidazole 18-20 interleukin 6 Homo sapiens 64-68 35222804-5 2022 Additionally, Cr(VI)-induced senescent L02 hepatocytes showed upregulated inflammation-related factors, such as IL-6 and fibroblast growth factor 23 (FGF23), which also exhibited reactive oxygen species (ROS) accumulation derived from mitochondria accompanied with increased concentration of intracellular calcium ions (Ca2+) and activity of nuclear factor kappa B (NF-kappaB). chromium hexavalent ion 14-20 interleukin 6 Homo sapiens 112-116 35222804-6 2022 Of note is that ROS inhibition by N-acetyl-Lcysteine pretreatment not only alleviated Cr(VI)-induced premature senescence but also reduced the elevated intracellular Ca2+, activated NF-kappaB, and secretion of IL-6/FGF23. n-acetyl-lcysteine 34-52 interleukin 6 Homo sapiens 210-214 35222804-6 2022 Of note is that ROS inhibition by N-acetyl-Lcysteine pretreatment not only alleviated Cr(VI)-induced premature senescence but also reduced the elevated intracellular Ca2+, activated NF-kappaB, and secretion of IL-6/FGF23. chromium hexavalent ion 86-92 interleukin 6 Homo sapiens 210-214 35178353-7 2022 We showed a pro-inflammatory/pro-oxidative milieu increasing along treatment with nilotinib compared with imatinib or dasatinib, as demonstrated by higher hs-CRP and oxLDL levels and increased IL6/IL10 and TNFalpha/IL10 ratios only in nilotinib cohort. nilotinib 82-91 interleukin 6 Homo sapiens 193-196 35106811-7 2022 The catabolic enzyme MMP3 (p = 0.0001) and proinflammatory cytokine interleukin 6 (p = 0.036) were downregulated by U0126 in NPCs under inflammatory conditions. U 0126 116-121 interleukin 6 Homo sapiens 68-81 35276864-4 2022 The levels of pro-inflammatory cytokines, IL-6, IL-8, ENA-78, and GCP-2 were decreased in a carvacrol dose-dependent manner. carvacrol 92-101 interleukin 6 Homo sapiens 42-46 34597384-11 2022 FMDBA correlated with serum testosterone (r=0.45, p<0.001), IL-6 (r=-0.41, P=0.002), and CRP (r=-0.28, P=0.041). fmdba 0-5 interleukin 6 Homo sapiens 60-64 35021097-5 2022 Blocking polyamine import prevents efferocytosis from suppressing macrophage interleukin (IL)-1beta or IL-6. Polyamines 9-18 interleukin 6 Homo sapiens 103-107 34477530-3 2022 METHODS: The dose-effect of maslinic acid on HeLa cells, a human cervical cancer cell line, was first evaluated, including cytotoxicity, IL-6 secretion, IL-6 receptor (IL-6R) expression, proliferation potential and apoptosis status. maslinic acid 28-41 interleukin 6 Homo sapiens 137-141 34477530-5 2022 RESULTS: Maslinic acid dose-dependently inhibited cell growth and proliferation potential, reduced IL-6 secretion, cervical expression of IL-6R and induced apoptosis of HeLa cells in vitro. maslinic acid 9-22 interleukin 6 Homo sapiens 99-103 35043219-5 2022 Importantly, the levels of salivary IL-6, IL-10, IFN-gamma, and TNF-alpha in RAS patients were significantly decreased following prednisone treatment (all P < 0.001). Prednisone 129-139 interleukin 6 Homo sapiens 36-40 2592764-4 1989 Of urine samples from patients with mesangial proliferative glomerulonephritis (PGN) 50% were found to contain significant IL-6 activity (ranging from 30 to 126 pg/ml). pgn 80-83 interleukin 6 Homo sapiens 123-127 2592764-7 1989 Furthermore, there was some relationship between the levels of urine IL-6 and the progressive stage of PGN. pgn 103-106 interleukin 6 Homo sapiens 69-73 2592764-8 1989 Finally, by immunohistochemical staining using an anti-IL-6 mAb, it was shown that MC in the affected glomeruli of PGN patients produced IL-6, whereas MC obtained from the patients with membranous nephropathy, minimal change nephrotic syndrome or normal kidney were not found to produce IL-6. pgn 115-118 interleukin 6 Homo sapiens 55-59 2592764-8 1989 Finally, by immunohistochemical staining using an anti-IL-6 mAb, it was shown that MC in the affected glomeruli of PGN patients produced IL-6, whereas MC obtained from the patients with membranous nephropathy, minimal change nephrotic syndrome or normal kidney were not found to produce IL-6. pgn 115-118 interleukin 6 Homo sapiens 137-141 2592764-8 1989 Finally, by immunohistochemical staining using an anti-IL-6 mAb, it was shown that MC in the affected glomeruli of PGN patients produced IL-6, whereas MC obtained from the patients with membranous nephropathy, minimal change nephrotic syndrome or normal kidney were not found to produce IL-6. pgn 115-118 interleukin 6 Homo sapiens 137-141 2592764-9 1989 These data suggest that deregulated production of IL-6 is involved in PGN and the measurement of urine IL-6 is helpful for the differential diagnosis of PGN as well as for monitoring the progression of PGN. pgn 70-73 interleukin 6 Homo sapiens 50-54 2592764-9 1989 These data suggest that deregulated production of IL-6 is involved in PGN and the measurement of urine IL-6 is helpful for the differential diagnosis of PGN as well as for monitoring the progression of PGN. pgn 153-156 interleukin 6 Homo sapiens 103-107 2592764-9 1989 These data suggest that deregulated production of IL-6 is involved in PGN and the measurement of urine IL-6 is helpful for the differential diagnosis of PGN as well as for monitoring the progression of PGN. pgn 153-156 interleukin 6 Homo sapiens 103-107 3265388-0 1988 Glucocorticosteroid-dependent synergy between interleukin 1 and interleukin 6 for human B lymphocyte differentiation. glucocorticosteroid 0-19 interleukin 6 Homo sapiens 64-77 2410927-3 1985 The homogeneity of purified BCDF was evidenced by the following: (i) the specific activity was 1.7 X 10(7) units/mg of protein, (ii) only two bands, Mr 19,000 and 21,000, were identified by NaDodSO4/PAGE under reduced as well as nonreduced conditions, and (iii) BCDF activity was recovered from the gel after NaDodSO4/PAGE in the fractions corresponding to protein bands of Mr 19,000 or 21,000. nadodso4 190-198 interleukin 6 Homo sapiens 28-32 2410927-3 1985 The homogeneity of purified BCDF was evidenced by the following: (i) the specific activity was 1.7 X 10(7) units/mg of protein, (ii) only two bands, Mr 19,000 and 21,000, were identified by NaDodSO4/PAGE under reduced as well as nonreduced conditions, and (iii) BCDF activity was recovered from the gel after NaDodSO4/PAGE in the fractions corresponding to protein bands of Mr 19,000 or 21,000. nadodso4 309-317 interleukin 6 Homo sapiens 28-32 6601516-5 1983 Molecular sieve chromatography employing Sephadex G-100 revealed an apparent molecular weight for HSF of 25-40,000. sephadex 41-55 interleukin 6 Homo sapiens 98-101 33988261-0 2021 Poly(I:C) enhances the efficacy of phagocytosis checkpoint blockade immunotherapy by inducing IL-6 production. Poly I-C 0-9 interleukin 6 Homo sapiens 94-98 33988261-4 2021 Poly(I:C) activation leads to a potent immune response characterized by the production of proinflammatory cytokines, especially IL-6. Poly I-C 0-9 interleukin 6 Homo sapiens 128-132 33877803-5 2021 Second, treatment with Ramelteon reduced expressions of IL-6, TNF-alpha, and IL-1beta. ramelteon 23-32 interleukin 6 Homo sapiens 56-60 33949204-8 2021 p55PIK deficiency and TAT-N15 significantly inhibited the cigarette smoke extract-induced IL-6, IL-8, and activation of the Akt and the NF-kappaB pathway in BEAS-2B. tat-n15 22-29 interleukin 6 Homo sapiens 90-94 33550164-7 2021 We found that TNF-alpha, IL-1beta, IL-6, and IL-8 were the four immune mediators that elevated in most of the samples derived from patients with CP/CPPS and the EAP models. phosphorylethanolamine 161-164 interleukin 6 Homo sapiens 35-39 33683214-10 2021 Cortisol, CRP and IL-6 levels were higher in patients with low TSH and FT3 levels. CHEMBL240806 71-74 interleukin 6 Homo sapiens 18-22 33582592-9 2021 The GMSC-Exos group showed lower Tumor Necrosis Factor-alpha (TNF-alpha), Interleukin-6 (IL-6), Interleukin-1beta (IL-1beta), and cluster of differentiation 86 (CD86) expression levels than the high-lipid group, and the highest levels of Interleukin-10 (IL-10) among all groups. gmsc 4-8 interleukin 6 Homo sapiens 74-87 33582592-9 2021 The GMSC-Exos group showed lower Tumor Necrosis Factor-alpha (TNF-alpha), Interleukin-6 (IL-6), Interleukin-1beta (IL-1beta), and cluster of differentiation 86 (CD86) expression levels than the high-lipid group, and the highest levels of Interleukin-10 (IL-10) among all groups. gmsc 4-8 interleukin 6 Homo sapiens 89-93 33445213-3 2021 Therefore, we aimed to determine the effects of astaxanthin (AST) supplementation on the circulating malondialdehyde (MDA) and interleukin 6 (IL-6) levels, and the expression of miR-146a and miR-126 in patients with T2DM. astaxanthine 61-64 interleukin 6 Homo sapiens 142-146 34047081-8 2021 It mainly acted on multiple targets, such as IL6, TNF, IL1 B and MAPK1, involving TNF signaling pathway and Toll-like receptor signaling pathway in RA treatment. Radium 148-150 interleukin 6 Homo sapiens 45-48 33882638-0 2021 Dual intracellular targeting by ruxolitinib and Mcl-1 inhibitor S63845 in IL-6 dependent myeloma cells blocks in vivo tumor growth. ruxolitinib 32-43 interleukin 6 Homo sapiens 74-78 33997590-9 2021 IL-6 showed a significant positive correlation with insulin sensitivity and significant negative correlation with insulin resistance and serum glutamate pyruvate transaminase. Pyruvic Acid 153-161 interleukin 6 Homo sapiens 0-4 33844371-7 2021 Results showed that the kirenol treatment enhanced the GSH and reduced MDA in the liver and renal tissues and restored TNF-alpha and IL-6. kirenol 24-31 interleukin 6 Homo sapiens 133-137 33866132-9 2021 Based on limited data, we demonstrated that severely ill COVID-19 patients benefited from BBD treatment due to a reduction in the overproduction of IL-6. 5-tert-butyl-1,3-benzodioxole 90-93 interleukin 6 Homo sapiens 148-152 33854314-7 2021 Cytotoxicity studies using MTT assay demonstrated enhanced growth inhibitory effect on lung tumor cells A549 and significant reduction of proinflammatory cytokines such as tumor necrosis factor-alpha, interleukin-6 and interleukin-10 compared to the pure drug. monooxyethylene trimethylolpropane tristearate 27-30 interleukin 6 Homo sapiens 201-214 33621387-3 2021 We have shown that JSI-124 at non-cytotoxic concentration (20 nM) can inhibit the IL-6/STAT3/NF-kappaB positive feedback loop in breast myofibroblasts, which enabled persistent inactivation of these cells. cucurbitacin I 19-26 interleukin 6 Homo sapiens 82-86 33303271-8 2021 RESULTS: The intervention with metoprolol significantly reduced serum tumor necrosis factor-alpha and interleukin-6 (P < .05) and peritoneal interleukin-6 (P < .01) compared with those of animals treated with saline. Metoprolol 31-41 interleukin 6 Homo sapiens 102-115 33303271-8 2021 RESULTS: The intervention with metoprolol significantly reduced serum tumor necrosis factor-alpha and interleukin-6 (P < .05) and peritoneal interleukin-6 (P < .01) compared with those of animals treated with saline. Metoprolol 31-41 interleukin 6 Homo sapiens 141-154 33998893-5 2021 Relative to the LPS-activated and untreated control (M[LPS]), both 25 muM CBD and 10 muM Dex reduced expression of pro-inflammatory markers-tumor necrosis factor alpha, interleukin 1 beta, and regulated on activation, normal T cell expressed and secreted (RANTES)-as well as the pleiotropic marker interleukin-6 (IL-6). Cannabidiol 74-77 interleukin 6 Homo sapiens 298-311 33998893-5 2021 Relative to the LPS-activated and untreated control (M[LPS]), both 25 muM CBD and 10 muM Dex reduced expression of pro-inflammatory markers-tumor necrosis factor alpha, interleukin 1 beta, and regulated on activation, normal T cell expressed and secreted (RANTES)-as well as the pleiotropic marker interleukin-6 (IL-6). Cannabidiol 74-77 interleukin 6 Homo sapiens 313-317 33741556-7 2021 JAK1-dependent pathways (interferon (IFN)alpha/pSTAT5, interleukin (IL)-6/pSTAT1) were among the most potently inhibited by all JAKinibs in healthy and RA blood, with filgotinib exhibiting the greatest selectivity for JAK1 pathways. GLPG0634 167-177 interleukin 6 Homo sapiens 55-73 33686181-6 2021 Palmitic acid up-regulated TLR4 as well as pro-inflammatory cytokines IL6 and TNFalpha contrasting with DHA effect. Palmitic Acid 0-13 interleukin 6 Homo sapiens 70-73 33671522-6 2021 TGE at 400 microg/mL significantly inhibited LPS-induced TNF-alpha and IL-6 productions. CHEMBL551052 0-3 interleukin 6 Homo sapiens 71-75 33602262-7 2021 RESULTS: All the SSRIs, including paroxetine, fluoxetine, sertraline, citalopram, and fluvoxamine, show a visible cytotoxicity within the range of applied doses, and a paradoxical effect on astrocytic inflammatory responses as manifested by the promotion of inducible nitric oxide synthase (iNOS) and/or nitric oxide (NO) and the inhibition of interleukin 6 (IL-6) and/or interleukin 1beta (IL-1beta). Citalopram 70-80 interleukin 6 Homo sapiens 344-357 33602262-7 2021 RESULTS: All the SSRIs, including paroxetine, fluoxetine, sertraline, citalopram, and fluvoxamine, show a visible cytotoxicity within the range of applied doses, and a paradoxical effect on astrocytic inflammatory responses as manifested by the promotion of inducible nitric oxide synthase (iNOS) and/or nitric oxide (NO) and the inhibition of interleukin 6 (IL-6) and/or interleukin 1beta (IL-1beta). Citalopram 70-80 interleukin 6 Homo sapiens 359-363 33539038-12 2021 According to the cytokine antibody array results, hOBs pretreated with AZA had significantly increased production of several inflammatory cytokines (P<0.05), in which the expression levels of IL-6 and IL-8 were the most dramatically increased upon LTA stimulation (P<0.01). Decitabine 71-74 interleukin 6 Homo sapiens 192-196 33166496-4 2021 Primary human articular chondrocyte was employed as a model for in vitro assessment of IL-6 effects in cell viability, cellular oxidative stress and iron homeostasis by MTT, MDA, ROS and Iron Colorimetric assays. monooxyethylene trimethylolpropane tristearate 169-172 interleukin 6 Homo sapiens 87-91 33613982-5 2021 In addition, pro-inflammatory cytokine expressions of TNF-alpha and IL-6 induced by the binary mixture of Phe and Flu were all alleviated by co-treatment with PI3K/AKT and NF-kappaB specific inhibitors (LY294002 and BAY11-7082). phenanthrene 106-109 interleukin 6 Homo sapiens 68-72 32396609-4 2021 As shown with immunoblots and ELISA, empagliflozin significantly suppressed increased levels of ICAM-1,VCAM-1,TNF-alpha,IL-6 in human and murine HFpEF myocardium and attenuated pathological oxidative parameters (H2O2, 3-nitrotyrosine, GSH, lipid peroxide) in both cardiomyocyte cytosol and mitochondria in addition to improved endothelial vasorelaxation. empagliflozin 37-50 interleukin 6 Homo sapiens 120-124 33420112-5 2021 Proteomics analysis of OCT-treated skin wounds revealed significant lower levels of key players in tissue remodeling as well as reepithelization after wounding such as pro-inflammatory cytokines (IL-8, IL-6) and matrix-metalloproteinases (MMP1, MMP2, MMP3, MMP9) when compared to controls. octenidine 23-26 interleukin 6 Homo sapiens 202-206 33094728-6 2021 Pro-inflammatory cytokines; C-reactive protein, TNF-alpha, and interleukin-6 showed significant reduction after treatment with EMPA, compared to baseline levels. empagliflozin 127-131 interleukin 6 Homo sapiens 63-76 33441226-5 2021 Then, in the 16HEB cells stimulated by STAT3 inhibitor Stattic or p38 MAPK inhibitor SB203580 in combination with HDM, the mRNA and protein expression levels of IL-6 and IL-8 were detected by qPCR and CBA. SB 203580 85-93 interleukin 6 Homo sapiens 161-165 33441226-8 2021 Interestingly, while SB203580 inhibited the activation of p38 MAPK signaling pathway, it only inhibited the mRNA levels of IL-6 and IL-8 in HDM-induced 16HBE cells, but had no effect on their protein levels. SB 203580 21-29 interleukin 6 Homo sapiens 123-127 33396220-9 2020 In combination with polyvinyl alcohol and chitosan, BV significantly accelerates the wound healing process, increasing the hydroxyproline and glutathione and lowering the IL-6 level in wound tissues. Polyvinyl Alcohol 20-37 interleukin 6 Homo sapiens 171-175 33374733-8 2020 Butyrate decreased IL-4-induced IL-6 production. Butyrates 0-8 interleukin 6 Homo sapiens 32-36 33490193-6 2020 The high level of IL-6 enhanced C2C12 myotube atrophy through the activation of JAK/STAT3, while inhibiting JAK/STAT3 pathway by ruxolitinib (a JAK1/2 inhibitor) or C188-9 (a STAT3 inhibitor) significantly attenuated C2C12 myotube atrophy induced by IL-6. ruxolitinib 129-140 interleukin 6 Homo sapiens 18-22 33269450-4 2020 Phosprenyl, on the contrary, increased production of IL-1beta and the levels of IL-6 and IL-10. phosprenyl 0-10 interleukin 6 Homo sapiens 80-84 32809969-6 2020 In a single treated patient, we also evaluated the alteration of myeloid cell functional activity.RESULTSWe provide evidence that patients treated with baricitinib had a marked reduction in serum levels of IL-6, IL-1beta, and TNF-alpha, a rapid recovery of circulating T and B cell frequencies, and increased antibody production against the SARS-CoV-2 spike protein, all of which were clinically associated with a reduction in the need for oxygen therapy and a progressive increase in the P/F (PaO2, oxygen partial pressure/FiO2, fraction of inspired oxygen) ratio.CONCLUSIONThese data suggest that baricitinib prevented the progression to a severe, extreme form of the viral disease by modulating the patients" immune landscape and that these changes were associated with a safer, more favorable clinical outcome for patients with COVID-19 pneumonia.TRIAL REGISTRATIONClinicalTrials.gov NCT04438629.FUNDINGThis work was supported by the Fondazione Cariverona (ENACT Project) and the Fondazione TIM. baricitinib 152-163 interleukin 6 Homo sapiens 206-210 33174050-5 2020 ELISA showed that SFN was associated with a time- and dose-dependent reduction in poly(I:C)-stimulated production of interleukin (IL)-8, chemoattractant protein-1, IL-6, MMP-1 and MMP-3 by HCFs. Poly I-C 82-91 interleukin 6 Homo sapiens 164-168 33496116-9 2020 The results of molecular docking showed that baicalein,berberine,licochalcone A and 6-gingerol had a high affinity with SRC,STAT3,TNF and IL6. licochalcone A 65-79 interleukin 6 Homo sapiens 138-141 33244226-7 2020 Moreover, miR-486-5p expression was significantly correlated with the expression of IL-6, IL-8, TNF-alpha, and IFN-gamma. mir-486-5p 10-20 interleukin 6 Homo sapiens 84-88 33224259-8 2020 The results demonstrated that RTA and RTB inhibited the production of NO, TNF-alpha, and IL-6 and suppressed liver fibrosis. (2,2':6',2'-Terpyridine)-(1,10-Phenanthroline)ruthenium (Ii) 38-41 interleukin 6 Homo sapiens 89-93 33168071-17 2020 Pre-treatment with IL-6 and TGF-beta inhibitors prevented et-1 upregulation induced by ATA-ICs by 85% and 77%, respectively. Amitrole 87-90 interleukin 6 Homo sapiens 19-23 33063931-5 2020 In vitro, we found that Astilbin pre-treatment inhibited lipopolysaccharide (LPS)-induced overproduction of inflammation-correlated cytokines such as nitric oxide (NO), prostaglandin E2 (PGE2), tumour necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6), and suppressed overexpression of inflammatory enzymes such as inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2). astilbin 24-32 interleukin 6 Homo sapiens 239-252 33063931-5 2020 In vitro, we found that Astilbin pre-treatment inhibited lipopolysaccharide (LPS)-induced overproduction of inflammation-correlated cytokines such as nitric oxide (NO), prostaglandin E2 (PGE2), tumour necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6), and suppressed overexpression of inflammatory enzymes such as inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2). astilbin 24-32 interleukin 6 Homo sapiens 254-258 33406924-7 2020 There was a positive repeated measures correlation (rmcorr = 0.667) between the aMMP-8 and IL-6 levels. AMMP 80-84 interleukin 6 Homo sapiens 91-95 32642806-1 2020 A patient with COVID-19-related severe respiratory failure, with insufficient response to an antiretroviral therapy, hydroxychloroquine and Interleukin-6 (IL-6) antagonist therapy, presented a prompt resolution of the respiratory function and improvement in the radiological picture after baricitinib at an oral dose of 4 mg per day for 2 weeks. baricitinib 289-300 interleukin 6 Homo sapiens 155-159 32660717-9 2020 After anaesthesia with propofol and remifentanil, IL17 (P=0.013), interferon gamma (P=0.003), and MICA (P=0.001) decreased, but IL6 (P=0.006) and L-selectin (P=0.001) increased. Propofol 23-31 interleukin 6 Homo sapiens 128-131 32541245-10 2020 We hypothesize that continuing with low level of prednisolone without azathioprine may have abrogated activated Tregs, Bregs and IL-6 production and therefore permitting the activation of CD8 T cells, clearing the virus. Prednisolone 49-61 interleukin 6 Homo sapiens 129-133 33164356-4 2020 The results showed that adenosine, epigoitrin, chlorogenic acid, caffeic acid, cichoric acid, corynoline, baicalin, wogonoside, wogonin and oroxylin A had a certain regulatory effect on inflammatory factor tumor necrosis factor(TNF-alpha), interleukin(IL-1beta) and IL-6 at specific concentrations in a dose-dependent manner. chicoric acid 79-92 interleukin 6 Homo sapiens 266-270 33145215-15 2020 The decrease in IL-6 level reflects anti-inflammatory effect and probable neuroprotective potential of propofol and sevoflurane. Propofol 103-111 interleukin 6 Homo sapiens 16-20 32519707-10 2020 Moreover, the overexpression of transcription factor EB (TFEB), the master transcriptional regulator of autophagy and lysosome biogenesis, partially relieved arsenic-inhibited lysosomal CTSD and CTSL expressions, recovered the disorder of autophagic flux, promoted the production of pro-inflammatory cytokines TNF-alpha, IL-1beta, IL-6, and IL-12, and reduced anti-inflammatory cytokine IL-10 secretion. Arsenic 158-165 interleukin 6 Homo sapiens 331-335 32473600-6 2020 In a case series of patients with bilateral COVID-19 pneumonia, baricitinib treatment was associated with clinical and radiologic recovery, a rapid decline in SARS-CoV-2 viral load, inflammatory markers, and IL-6 levels. baricitinib 64-75 interleukin 6 Homo sapiens 208-212 32418888-5 2020 We discovered that PCCs secrete CCL3 and stimulate IL-6, CCL2, ICAM-1 and VCAM-1 expression in MSCs and that the MSC-PCC crosstalk can be disrupted by the lipid-lowering drug simvastatin, which displays pleiotropic effects on cell metabolism and suppresses IL-6 and CCL2 production by MSCs and CCL3 secretion by PCCs. pyridinium chlorochromate 19-22 interleukin 6 Homo sapiens 257-261 32802141-8 2020 Shikonin significantly inhibited Der p 2-induced expression of interleukin (IL)-6, IL-9, and IL-17A; monocyte chemoattractant protein (MCP)-1; macrophage inflammatory protein (MIP)-1alpha; MIP-1beta; and Chemokine (C-C motif) ligand 5 (RANTES). shikonin 0-8 interleukin 6 Homo sapiens 63-81 32803073-3 2020 An unnatural amino acid was genetically incorporated into a specific site with the highest accessibility in a human interleukin-6 (IL-6)-targeting protein binder with a size of 30.8 kDa, followed by conjugation with palmitic acid using cooper-free click chemistry. Palmitic Acid 216-229 interleukin 6 Homo sapiens 116-129 32803073-3 2020 An unnatural amino acid was genetically incorporated into a specific site with the highest accessibility in a human interleukin-6 (IL-6)-targeting protein binder with a size of 30.8 kDa, followed by conjugation with palmitic acid using cooper-free click chemistry. Palmitic Acid 216-229 interleukin 6 Homo sapiens 131-135 32684834-8 2020 In addition, SDG increased NO release and decreased the levels of IL-1beta, IL-6, and TNF-alpha in LPS-treated HUVECs. secoisolariciresinol diglucoside 13-16 interleukin 6 Homo sapiens 76-80 32366718-9 2020 Pin2[G] showed superior immunomodulatory activity in increasing chemokine production by a human bronchial cell line and suppressing poly(IC)-induced pro-inflammatory IL6 production. Poly I-C 132-140 interleukin 6 Homo sapiens 166-169 32503225-6 2020 In addition, pentadecanoic acid suppressed interleukin-6 (IL-6)-induced JAK2/STAT3 signaling, induced cell cycle arrest at the sub-G1 phase, and promoted caspase-dependent apoptosis in MCF-7/SC. pentadecanoic acid 13-31 interleukin 6 Homo sapiens 43-56 32503225-6 2020 In addition, pentadecanoic acid suppressed interleukin-6 (IL-6)-induced JAK2/STAT3 signaling, induced cell cycle arrest at the sub-G1 phase, and promoted caspase-dependent apoptosis in MCF-7/SC. pentadecanoic acid 13-31 interleukin 6 Homo sapiens 58-62 32991316-15 2020 Dialysates collected after IIS treatment induced oxidative stress in MC (+29%, P < 0.05) and stimulated IL-6 synthesis (+64%, P < 0.05) in MC; no such effect was seen in dialysates obtained after simultaneous IIS and NAC i.v. iis 27-30 interleukin 6 Homo sapiens 104-108 32696743-18 2020 Conclusion Activation of the TGF-beta1/SMAD2/SMAD3 signaling pathway in A549 cells induced by MCTP increases IL-6 secretion, thus promoting the proliferation and migration of HPASMCs. monocrotaline pyrrole 94-98 interleukin 6 Homo sapiens 109-113 32420479-5 2020 Lauric acid (LA) typically increased the mRNA expression of glial-derived neurotrophic factor (Gdnf), interleukin-6 (Il6), and C-C motif chemokine 2 (Ccl2) in astrocytes. lauric acid 0-11 interleukin 6 Homo sapiens 102-115 32420479-5 2020 Lauric acid (LA) typically increased the mRNA expression of glial-derived neurotrophic factor (Gdnf), interleukin-6 (Il6), and C-C motif chemokine 2 (Ccl2) in astrocytes. lauric acid 0-11 interleukin 6 Homo sapiens 117-120 32361897-9 2020 The cell invasion and wound healing assay followed by reduced expression both protein (MMP 2, MMP 9) and cytokine (IL6, IL10) had signified the effectiveness of HBNP against cancer metastasis. hbnp 161-165 interleukin 6 Homo sapiens 115-118 32179241-10 2020 Anthocyanin supplementation has dose-response relationships with decreased inflammatory cytokines IL-6, TNF-alpha and oxidative stress biomarkers 8-iso-PGF2alpha, 8-OHdG and MDA (P for trend, <0.05). Anthocyanins 0-11 interleukin 6 Homo sapiens 98-102 32179241-11 2020 Furthermore, a strong positive correlation was observed between the changes in the urine 8-iso-PGF2alpha , 8-OHdG levels and serum IL-6 levels in subjects from anthocyanin groups after 12 weeks of treatment. Anthocyanins 160-171 interleukin 6 Homo sapiens 131-135 32035144-4 2020 Our results showed that hesperetin significantly relieved the symptoms of DSS -induced colitis and increased the expressions of zonula occludens-1 (ZO-1), occludin and mucin2 (MUC-2) as well as the decrease of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-18, HMGB1 and IL-6. hesperetin 24-34 interleukin 6 Homo sapiens 292-296 32046103-6 2020 Furthermore, we found DMU-214 triggered changes in expression of several migration- and proliferation-related genes (SMAD7, THBS1, IGFBP3, KLF4, Il6, ILA, SOX4, IL15, SRF, RGCC, GPR56) and proteins (GPR56, RGCC, SRF, SMAD7, THBS1), which have been shown to interact to each other to reduce cell proliferation and motility. 3,7-dimethyluric acid 22-25 interleukin 6 Homo sapiens 145-148 31933104-6 2020 SAK3 inhibited scopolamine-induced cellular apoptosis (morphologically and by determination of pro- and anti-apoptotic factor levels), increase in ROS levels, decrease in choline acetyltransferase level, phosphorylation of NF-kappaB, activation of Akt, JNK and p38 intracellular signaling pathways, and elevation of proinflammatory cytokines IL-1beta and IL-6, but not enhanced level of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1). Scopolamine 15-26 interleukin 6 Homo sapiens 355-359 31943744-0 2020 IL-6 expression promoted by Poly(I:C) in cervical cancer cells regulates cytokine expression and recruitment of macrophages. Poly I-C 28-37 interleukin 6 Homo sapiens 0-4 33463223-6 2020 In this work, we hypothesized that new copolymers composed of CPTEG and SA would combine the advantages of both monomers in terms of enhanced thermal properties, maintaining antigenicity of encapsulated proteins following nanoparticle synthesis, and superior cellular internalization and activation by APCs, demonstrated by the upregulation of costimulatory markers CD80, CD86, and CD40, as well as the secretion of proinflammatory cytokines IL-6, IL-1beta, and TNF-alpha. copolymers 39-49 interleukin 6 Homo sapiens 442-446 33463223-6 2020 In this work, we hypothesized that new copolymers composed of CPTEG and SA would combine the advantages of both monomers in terms of enhanced thermal properties, maintaining antigenicity of encapsulated proteins following nanoparticle synthesis, and superior cellular internalization and activation by APCs, demonstrated by the upregulation of costimulatory markers CD80, CD86, and CD40, as well as the secretion of proinflammatory cytokines IL-6, IL-1beta, and TNF-alpha. sebacic acid 72-74 interleukin 6 Homo sapiens 442-446 33350987-3 2020 Within one hour, R-837 induced activation of the nucleus of the solitary tract, as well as a small increase in nasal IL-6, but otherwise in the absence of an overt inflammatory response. Imiquimod 17-22 interleukin 6 Homo sapiens 117-121 31821937-4 2020 The results demonstrated that treatment with xanthone reduced the production of pro-inflammatory cytokines and chemokines including interleukin (IL)-1beta, IL-6, IL-8, and expression of chemokines thymus and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) in tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma-stimulated HaCaT cells. Xanthones 45-53 interleukin 6 Homo sapiens 156-160 32444566-11 2020 Secretion of IL-6 in 21% FiO2 with xenon group at 32 C was less than that of the control group. Xenon 35-40 interleukin 6 Homo sapiens 13-17 31520792-4 2019 Here we observed that IFITM1 and MX1, and a proinflammatory cytokine IL-6 expression was induced by polyinosinic-polycytidylic acid (poly IC) in hCMEC/D3 human brain microvascular endothelial cells. Poly I-C 100-131 interleukin 6 Homo sapiens 69-73 31520792-4 2019 Here we observed that IFITM1 and MX1, and a proinflammatory cytokine IL-6 expression was induced by polyinosinic-polycytidylic acid (poly IC) in hCMEC/D3 human brain microvascular endothelial cells. Poly I-C 133-140 interleukin 6 Homo sapiens 69-73 32203941-5 2019 Exposure of MC to the studied dialysates caused intracellular oxidative stress and significantly increased expression of the genes regulating the synthesis of interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), transforming growth factor-beta (TGF-beta), vascular cell adhesion molecule 1 (VCAM-1) and vascular endothelial growth factor (VEGF). Methylcholanthrene 12-14 interleukin 6 Homo sapiens 159-172 32203941-5 2019 Exposure of MC to the studied dialysates caused intracellular oxidative stress and significantly increased expression of the genes regulating the synthesis of interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), transforming growth factor-beta (TGF-beta), vascular cell adhesion molecule 1 (VCAM-1) and vascular endothelial growth factor (VEGF). Methylcholanthrene 12-14 interleukin 6 Homo sapiens 174-178 32203941-6 2019 Secretion of the studied molecules from MC treated with dialysates was increased: by 96% for IL-6 (P < 0.01), 34% for MCP-1(P < 0.01), 24% for TGF-beta (P < 0.01), 27% for VCAM-1 (P < 0.01), and by 15% for VEGF (P < 0.01). Methylcholanthrene 40-42 interleukin 6 Homo sapiens 93-97 31515297-11 2019 Notably, combination fenretinide-tocilizumab-reparixin treatment significantly suppressed IL-6 and IL-8 release, stem cell gene expression, and invasion in these diverse CSCE populations. reparixin 45-54 interleukin 6 Homo sapiens 90-94 30856080-10 2019 These studies demonstrated that vitamin E, especially tocotrienol, was able to alleviate IL-1, IL-6, RANKL, iNOS and hs-CRP levels in relation to bone metabolism. Vitamin E 32-41 interleukin 6 Homo sapiens 95-99 31531960-8 2019 CONCLUSION: Our study suggests that elevated levels of IL-6 in new GCA are better suppressed by MR prednisone compared with IR prednisolone. Prednisolone 127-139 interleukin 6 Homo sapiens 55-59 31049957-7 2019 RESULTS: Production of IL-6, IL-8, MCP-1, and OPG was significantly increased by Poly I:C or Pam3CSK4 to a similar extent. Poly I-C 81-89 interleukin 6 Homo sapiens 23-27 31111539-6 2019 Poly (I:C) significantly upregulated proinflammatory cytokines, including tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-6, IL-1beta and type I interferon (IFN-alpha/beta), and the innate immune responses were significantly reduced by blocking TLR3 signaling. Poly I-C 0-9 interleukin 6 Homo sapiens 115-133 30472681-8 2019 In humans, preoperative administration of prucalopride, but not of VNS, decreased Il6 and Il8 expression in the muscularis externa and improved clinical recovery. prucalopride 42-54 interleukin 6 Homo sapiens 82-85 31144813-4 2019 Due to the ultrahigh loading capacity (817 mg/g) of TMB molecules, the sensitivity of TLISA toward inflammatory biomarkers interleukin-6 was 11.82 times higher than that of conventional ELISA, which paves an avenue to develop an ultrasensitive colorimetric immunoassay. 3,3',5,5'-tetramethylbenzidine 52-55 interleukin 6 Homo sapiens 123-136 31131517-10 2019 The decrease in hs-CRP, IL-6 and TNF-alpha in the CT group was significant compared to the control group (P <= 0.02). ct 50-52 interleukin 6 Homo sapiens 24-28 32215295-0 2020 Pioglitazone ameliorates neuronal damage after traumatic brain injury via the PPARgamma/NF-kappaB/IL-6 signaling pathway. Pioglitazone 0-12 interleukin 6 Homo sapiens 98-102 30478740-9 2019 Remarkable, after 6 h CdCl2-treatment, a relevant increase in TNF-alpha, IL-6 and IL-8 mRNA was observed and this effect was blocked by the presence of an ERbeta-selective antagonist. Cadmium Chloride 22-27 interleukin 6 Homo sapiens 73-77 30648905-6 2019 In epithelial cells, palmitic acid (SFA) combined with poly(I:C) also led to greater IL-6 release. Palmitic Acid 21-34 interleukin 6 Homo sapiens 85-89 30648905-6 2019 In epithelial cells, palmitic acid (SFA) combined with poly(I:C) also led to greater IL-6 release. Poly I-C 55-64 interleukin 6 Homo sapiens 85-89 30729713-1 2019 AIM: Vitamin D3 or 25(OH)D3 may have a potential role in rheumatoid arthritis (RA) pathogenesis by inhibiting the expression of pro-inflammatory cytokines including interleukin-6 (IL-6). Calcifediol 19-27 interleukin 6 Homo sapiens 165-178 30729713-1 2019 AIM: Vitamin D3 or 25(OH)D3 may have a potential role in rheumatoid arthritis (RA) pathogenesis by inhibiting the expression of pro-inflammatory cytokines including interleukin-6 (IL-6). Calcifediol 19-27 interleukin 6 Homo sapiens 180-184 30987646-6 2019 RESULTS: HMVECs that had reduced eNOS expression had a significantly elevated increase in IL-6, IL-8 and IP-10 production after Poly I:C. Poly I-C 128-136 interleukin 6 Homo sapiens 90-94 31056982-5 2019 Additionally, osthole treatment reduced the expression of microglia and glial scar, lowered the level of the proinflammatory cytokines interleukin (IL)-6, IL-1beta, and tumor necrosis factor-alpha (TNF-alpha), and blocked the activation of nuclear factor kappa B (NF-kappaB). osthol 14-21 interleukin 6 Homo sapiens 135-153 30404019-6 2019 ATP-induced IL-6 production was significantly inhibited by p38 inhibitors, SB203580, and doramapimod. SB 203580 75-83 interleukin 6 Homo sapiens 12-16 30404019-6 2019 ATP-induced IL-6 production was significantly inhibited by p38 inhibitors, SB203580, and doramapimod. doramapimod 89-100 interleukin 6 Homo sapiens 12-16 30404019-7 2019 Collagen type I production in SSc fibroblasts by ATP-induced IL-6/IL-6 receptor trans-signaling was inhibited by kaempferol and SB203580. SB 203580 128-136 interleukin 6 Homo sapiens 61-65 30810286-10 2019 Furthermore, XAV939 could inhibit the activation of both IL-6/STAT3 and PI3K/Akt signaling pathways. XAV939 13-19 interleukin 6 Homo sapiens 57-61 30918320-8 2019 We found that IL-6 levels at T2 and T3 were higher than those at T1 in both groups, although the increases were significant attenuated only in the propofol group. Propofol 147-155 interleukin 6 Homo sapiens 14-18 30600004-5 2019 Additionally, HMO-7 was found to stimulate the release of ROS, TNF-alpha and cytokines including IL-1beta, IL-2, IL-6 and IL-10 in RAW264.7 macrophages. hmo-7 14-19 interleukin 6 Homo sapiens 113-117 30964194-10 2019 The cytoprotective effects of SDX resulted from a reduction in a) ROS production, b) neo-synthesis and release of pro-inflammatory cytokines (TNFalpha, IL1, IL6, IL8), c) DNA damage induced by MGO or IR. glucuronyl glucosamine glycan sulfate 30-33 interleukin 6 Homo sapiens 157-160 30824840-4 2019 Patients with CTP class A had a significantly lower proportion of detectable IL-4 or IL-6, but a higher proportion of detectable IL-22 than patients with CTP class B/C. Cytidine Triphosphate 14-17 interleukin 6 Homo sapiens 85-89 30787349-10 2019 Deferiprone blocked Poly (I:C)-induced IL-6 production by HNECs but did not alter their migration in scratch assays. Poly I-C 20-30 interleukin 6 Homo sapiens 39-43 30692581-8 2019 Interestingly, butyrate supplementation decreased oxLDL-induced trained immunity in the MetSyn group for LPS-induced IL-6 responses and Pam3CSK4-induced TNF-alpha responses. Butyrates 15-23 interleukin 6 Homo sapiens 117-121 29934049-8 2019 Analysis in vitro by MTT test and Boyden chamber assay showed exogenous IL-6 and IL-8 (a relatively short period of treatment with recombinant IL-6 or IL-8 equivalent to the autocrine levels) could significantly promote the proliferation of human osteoblastic, endothelial and monocytic cells, as well as the migration of human endothelial cells. monooxyethylene trimethylolpropane tristearate 21-24 interleukin 6 Homo sapiens 72-76 30365050-8 2019 In addition, cotreatment with the COX2 inhibitor CAY10404 and sesamin downregulated the expression of downstream molecules of COX2 [including interleukin (IL)1beta, IL6 and tumor necrosis factor alpha] compared with CAY10404 or sesamin alone. sesamin 62-69 interleukin 6 Homo sapiens 165-168 30096715-0 2019 Diarylheptanoids from Curcuma phaeocaulis Suppress IL-6-Induced STAT3 Activation. Diarylheptanoids 0-16 interleukin 6 Homo sapiens 51-55 30989958-6 2019 Different concentrations of SABTAT-LIP inhibited proliferation on HSF in varying degrees after intervention for different periods in a dose and time dependent manner;meanwhile,SAB-TAT-LIP significantly inhibited the migration and invasion of HSF. sabtat-lip 28-38 interleukin 6 Homo sapiens 66-69 30989958-6 2019 Different concentrations of SABTAT-LIP inhibited proliferation on HSF in varying degrees after intervention for different periods in a dose and time dependent manner;meanwhile,SAB-TAT-LIP significantly inhibited the migration and invasion of HSF. sabtat-lip 28-38 interleukin 6 Homo sapiens 242-245 30687454-4 2018 Methods and Results: Organic nitrates (ISMN, ISDN, and nitroglycerin (GTN)) augmented the oxidative burst and interleukin-6 release in cultured macrophages, whereas macitentan decreased the oxidative burst in isolated human leukocytes. Isosorbide Dinitrate 45-49 interleukin 6 Homo sapiens 110-123 30647536-4 2018 Moreover, propofol treatment downregulated the production of the proinflammatory cytokines interleukin-6, tumor necrosis factor, and interferon gamma in lipopolysaccharide-stimulated macrophages by enhancing ABCA1 expression. Propofol 10-18 interleukin 6 Homo sapiens 91-104 30786829-7 2018 In the vitamin K1 group, a 27 % decrease in serum levels of IL-6 (P = 0.006) and a 13 % decrease in DAS-28 (P = 0.041) were observed. Vitamin K 1 7-17 interleukin 6 Homo sapiens 60-64 30598636-2 2018 Methods: The mRNA and protein expression levels of KLF7 and the factors of TLR4/NF-kappaB/IL-6 inflammatory signal pathways were detected by qRT-PCR and Western blotting after cell culture with different concentrations of palmitic acid (PA). Palmitic Acid 222-235 interleukin 6 Homo sapiens 90-94 30598636-4 2018 KLF7 expression was downregulated while PA stimulated adipocytes, and then the mRNA and protein expressions of KLF7/p65 and downstream inflammatory cytokine IL-6 were detected. Palmitic Acid 40-42 interleukin 6 Homo sapiens 157-161 30598636-6 2018 Results: (1) High concentration of PA can promote the expression of TLR4, KLF7, and IL-6 in adipocytes. Palmitic Acid 35-37 interleukin 6 Homo sapiens 84-88 30598636-11 2018 Conclusion: PA promotes the expression of the inflammatory cytokine IL-6 by activating the TLR4/KLF7/NF-kappaB inflammatory signaling pathway. Palmitic Acid 12-14 interleukin 6 Homo sapiens 68-72 30096396-7 2018 Pioglitazone has potentially restored cellular antioxidants and reduced levels of IL-6 and TNF-alpha by declining expression of membrane RAGE and NF-kappaB. Pioglitazone 0-12 interleukin 6 Homo sapiens 82-86 30546959-7 2019 Mechanistically, MALAT1 recruited Brahma-related gene 1 (BRG1), a catalytic subunit of chromatin remodeling complex switching/sucrose non-fermentable (SWI/SNF), to the promoter region of IL-6 and CXCL8, and thus facilitated NF-kappaB to induce the expression of these inflammatory factors. Sucrose 126-133 interleukin 6 Homo sapiens 187-191 29574949-5 2018 Lipopolysaccharide derived from Porphyromonas gingivalis (Pg LPS) and IL-1beta significantly increase IL-6 production in HGFs. pg lps 58-64 interleukin 6 Homo sapiens 102-106 29574949-10 2018 IL-6 induces vascular endothelial growth factor (VEGF), matrix-metalloproteinase-1 (MMP-1), and cathepsin L production in HGFs in the presence of sIL-6R. sil-6r 146-152 interleukin 6 Homo sapiens 0-4 30175192-7 2018 Imiquimod-induced expression of interleukin (IL)-6, IL-8, and vascular endothelial growth factor (VEGF) was inhibited by TLR7 siRNA in HIOEC cells as determined by reverse transcription polymerase chain reaction (RT-PCR). Imiquimod 0-9 interleukin 6 Homo sapiens 32-50 30005373-6 2018 In this study, we analysed and compared the methylation status of IL6 promoter sequence from -1200bp to +27bp in antipsychotic-naive/free schizophrenia patients (N = 47) and matched healthy controls (N = 47) using bisulfite sequencing method. hydrogen sulfite 214-223 interleukin 6 Homo sapiens 66-69 30054566-7 2018 Stimulation with Poly (I:C) LMW induced a 15 to 17 fold increase in IL-6 production by HNEC-ALI control cells (p < 0.05) and HNEC-ALI-CRS cells (p = 0.004) whilst a 2.5 fold increase was observed in CRS HNEC submerged cultures. Poly I-C 17-31 interleukin 6 Homo sapiens 68-72 30054566-8 2018 Priming of cells with Poly (I:C) LMW reduced subsequent IL-6 secretion upon stimulation with TLR 2-4 agonists. Poly I-C 22-36 interleukin 6 Homo sapiens 56-60 30093956-9 2018 Vincamine also exerted anti-inflammatory activities by decreasing IL-6, IL-8, IL-1beta, TNF-alpha, TGF-beta expression. Vincamine 0-9 interleukin 6 Homo sapiens 66-70 29881282-8 2018 IL-6 was higher in the LPS group on day 2 (p=0.03) and day 3 (p=0.04). lps 23-26 interleukin 6 Homo sapiens 0-4 29875665-10 2018 The GLPG and/or SHB treatments restored the inhibitory effects of acetate on IL-6 and IL-8 production and the inhibitory effects of butyrate or propionate on IL-6 production, but not on IL-8. Butyrates 132-140 interleukin 6 Homo sapiens 158-162 29875665-14 2018 Conclusion: Activation of GPR41/43 mediates the effects of acetate on IL-6 and IL-8 production and the effects of butyrate and propionate on IL-6 production. Butyrates 114-122 interleukin 6 Homo sapiens 141-145 29143360-10 2018 In addition, FPTHQ treatment increased the protein levels of MMP3 and the mRNA levels of IL-6 and IL-8 in A2780 cells, indicating the appearance of senescence-associated secretary phenotype (SASP) in the cells. fpthq 13-18 interleukin 6 Homo sapiens 89-93 29412148-6 2018 A specific inhibitor of p38MAPK, SB203580 significantly decreased the secretion of IL-6 and IL-8, the major components of SASPs. SB 203580 33-41 interleukin 6 Homo sapiens 83-87 28893516-6 2018 Circulating IL-6 levels correlated inversely with echocardiography-based measures of RV function and RV-pulmonary artery (RV-PA) coupling. rv-pa 122-127 interleukin 6 Homo sapiens 12-16 28893516-10 2018 CONCLUSIONS: Serum IL-6 levels are independently associated with RV function and RV-PA coupling in PAH. rv-pa 81-86 interleukin 6 Homo sapiens 19-23 28490191-6 2018 MTT test proved the stimulatory effect on cell metabolism and viability of HSF cells. monooxyethylene trimethylolpropane tristearate 0-3 interleukin 6 Homo sapiens 75-78 29486738-13 2018 CpdA could significantly decrease expressions of IL-6, XIAP and IL-8, as well as excreted IL-8 levels together with reduced cancer viability after PTX treatment. CPDA 0-4 interleukin 6 Homo sapiens 49-53 29486738-14 2018 CONCLUSIONS: The acquired TLR4-mediated PTX resistance in BCA and melanoma is explained partly by the paracrine effect of IL-6 and IL-8 released into the tumor microenvironment and over-production of anti-apoptotic protein, XIAP, in BCA cells and importantly CpdA could reduce this effect and sensitize PTX-induced apoptosis in a synergistic manner. CPDA 259-263 interleukin 6 Homo sapiens 122-126 29027990-3 2018 In the present study, we demonstrated that GSIs, such as MK-0752 and RO4929097, inhibit breast tumor growth, but increase the breast cancer stem cell (BCSC) population in Notch3-expressing breast cancer cells, in a process that is coupled with IL6 induction and is blocked by the IL6R antagonist Tocilizumab (TCZ). 2,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide 69-78 interleukin 6 Homo sapiens 244-247 28875362-4 2018 Propofol potently decreased the pro-inflammatory mediators, such as nitric oxide, TNF-alpha, and IL-6, at both the transcriptional and translational levels. Propofol 0-8 interleukin 6 Homo sapiens 97-101 29316707-4 2018 Moreover, transfection with miR-199a-5p mimics reversed visfatin-induced increases in IL-6 and TNF-alpha production. mir-199a-5p 28-39 interleukin 6 Homo sapiens 86-90 30184535-0 2018 Butein Activates Autophagy Through AMPK/TSC2/ULK1/mTOR Pathway to Inhibit IL-6 Expression in IL-1beta Stimulated Human Chondrocytes. butein 0-6 interleukin 6 Homo sapiens 74-78 30184535-2 2018 In the present work we investigated the mechanism of Butein-mediated suppression of IL-6 expression in normal and human osteoarthritis (OA) chondrocytes under pathological conditions. butein 53-59 interleukin 6 Homo sapiens 84-88 30184535-9 2018 Butein increased the phosphorylation of AMPKalphaThr-172, TSC2Ser-1387 and ULK1Ser-317 and inhibited the phosphorylation of mTORSer-2448 and its downstream target p70S6K and increased autophagy flux that correlated with the suppression of the IL-1beta mediated expression of IL-6 in normal and OA chondrocytes. butein 0-6 interleukin 6 Homo sapiens 275-279 30184535-10 2018 In OA chondrocytes with siRNA-mediated knockdown of ATG5 expression, treatment with Butein failed to activate autophagy and abrogated the suppression of IL-1beta induced IL-6 expression. butein 84-90 interleukin 6 Homo sapiens 170-174 29237438-13 2017 However, hSF cells were more sensitive to sesamin than SW982 cells in terms of the anti-RA effect. sesamin 42-49 interleukin 6 Homo sapiens 9-12 29078260-4 2017 In vitro, we assessed the role of DHM on IL-6-induced migration of primary human pulmonary arterial smooth muscle cells (HPASMCs). dhm 34-37 interleukin 6 Homo sapiens 41-45 28983603-6 2017 Serum IL-6, TNF-alpha and CRP in patients with CIH were increased, while NO and NOS were decreased. cih 47-50 interleukin 6 Homo sapiens 6-10 28983603-12 2017 In conclusion, age, male gender, BMI, smoking and T2DM history, serum IL-6, TNF-alpha and CRP were positively correlated with CIH combined with hypertension, while NO and NOS were negatively correlated with CIH. cih 126-129 interleukin 6 Homo sapiens 70-74 28983603-15 2017 Increasing IL-6, TNF-alpha and CRP, and decreasing NO and NOS are biomarkers of CIH, which could be targets in diagnosis, treatment and prevention of CIH. cih 80-83 interleukin 6 Homo sapiens 11-15 29172280-5 2017 However, carboplatin-induced IL-6 and IL-8 production had a significant association withthe clinical response to chemotherapy (P=0.016 and P=0.038 respectively). Carboplatin 9-20 interleukin 6 Homo sapiens 29-33 29070858-6 2017 Also, in infected cells SM downregulates the expression of the inflammatory cytokines IL-6 and TNF-alpha. Samarium 24-26 interleukin 6 Homo sapiens 86-90 29062282-0 2017 Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib. ruxolitinib 137-148 interleukin 6 Homo sapiens 25-29 29228683-5 2017 Furthermore, we showed that lenalidomide inhibits the IL-6 secretion of mononuclear cells, triggered by CD8+CD28- T-cells. Lenalidomide 28-40 interleukin 6 Homo sapiens 54-58 29228683-6 2017 The addition of IL-6 counteracts the action of lenalidomide based stimulation of IFN-gamma secretion and induction of T-cell maturation but not the secretion of Granzyme B. Lenalidomide 47-59 interleukin 6 Homo sapiens 16-20 29228683-8 2017 Analysis of the IL-6 modulating cereblon-binding protein KPNA2 showed the similar degradation capacity of lenalidomide and pomalidomide without explaining the divergent effects. Lenalidomide 106-118 interleukin 6 Homo sapiens 16-20 28970500-0 2017 The FXR Agonist, Obeticholic Acid, Suppresses HCC Proliferation & Metastasis: Role of IL-6/STAT3 Signalling Pathway. obeticholic acid 17-33 interleukin 6 Homo sapiens 90-94 28686951-8 2017 Higher total phthalate levels were associated with higher levels of hs-CRP, IL-6 (all p < 0.05) and TNF-alpha but not MPO. phthalic acid 13-22 interleukin 6 Homo sapiens 76-80 28510691-13 2017 EPN cells treated with 5AZA-DC, demethylated LDOC1 regulatory regions, upregulated LDOC1 expression, and concomitantly decreased IL-6 secretion. Decitabine 23-30 interleukin 6 Homo sapiens 129-133 28653583-1 2017 INTRODUCTION: Peritoneal insufflation with warm-humidified (WH) CO2 gas during minimally invasive surgical procedures is purported to prevent hypothermia and peritoneal desiccation and is associated with decreased postoperative IL-6 levels. N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide 64-67 interleukin 6 Homo sapiens 228-232 29036956-14 2017 NSE combined with IL-6 on the 3rd day in ICU demonstrates the diagnostic significance of SAE. SELENAZOLE-4-CARBOXYAMIDE-ADENINE DINUCLEOTIDE 89-92 interleukin 6 Homo sapiens 18-22 28582666-9 2017 An ELISA-like assay with CdSe/ZnS quantum dot institution (QLISA; Quantum dot-linked immunosorbent assay) was developed to detect 0.05ng/mL IL-6, which makes it sufficiently sensitive as an immunosorbent assay. cdse 25-29 interleukin 6 Homo sapiens 140-144 28442557-5 2017 Incubation of cells in an HP (3.3 mM) medium caused an increased expression of the pro-inflammatory mediators intercellular adhesion molecule 1 (ICAM-1), interleukins (ILs) IL-1beta, IL-6, IL-8 and tumour necrosis factor alpha (TNF-alpha) (not corroborated at the protein levels for ICAM-1), as well as an increase in reactive oxygen/nitrogen species (ROS/RNS) production. Hematoporphyrins 26-28 interleukin 6 Homo sapiens 183-187 28730070-8 2017 Various signal pathway inhibitors, including SP600125 (JNK inhibitor), SB203580 (p38 MAPK inhibitor) and BAY11-7082 (NF-kappaB inhibitor) significantly decreased the UVB-induced secretion of IL-6 and IL-8 secretion (P<0.05). SB 203580 71-79 interleukin 6 Homo sapiens 191-195 28499612-6 2017 Pro inflammatory cytokines, IL1beta and TNFalpha were more expressed in arsenic-treated MDDCs while IL6 transiently was down regulated. Arsenic 72-79 interleukin 6 Homo sapiens 100-103 28427199-13 2017 The combinatorial treatment with polyI:C and anti-IL6 enhanced polyI:C-mediated anticancer activities through IL6/JAK2/STAT3 signalling, and apoptosis via TLR3-mediated caspase 3/8 pathway. Poly I-C 63-70 interleukin 6 Homo sapiens 50-53 28427199-13 2017 The combinatorial treatment with polyI:C and anti-IL6 enhanced polyI:C-mediated anticancer activities through IL6/JAK2/STAT3 signalling, and apoptosis via TLR3-mediated caspase 3/8 pathway. Poly I-C 63-70 interleukin 6 Homo sapiens 110-113 28188670-8 2017 These results suggested that combined treatment with low dose CPA could provide clinical benefits in aBTC patients under PPV, possibly through prevention of IL-6-mediated immune suppression. Cyclophosphamide 62-65 interleukin 6 Homo sapiens 157-161 28584401-4 2017 We first confirmed that erythromycin suppresses the transcriptional activity of nuclear factor-kappaB and activator protein-1 and the expression of its downstream targets, interleukin-6 and cyclooxygenase-2 in human colon cancer cells. Erythromycin 24-36 interleukin 6 Homo sapiens 172-185 27943400-5 2017 The injection of HMGB1 into the IMQ-treated skin further aggravated the psoriasis-like disease, enhanced the infiltration of CD3+ T cells, myeloperoxidase+ neutrophils and CD11c+ dendritic cells, increased the number of gammadelta T cells, and upregulated the mRNA expression of interleukin (IL)-6, tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma and IL-17 compared with the PBS injection. Imiquimod 32-35 interleukin 6 Homo sapiens 279-297 28420398-7 2017 RESULTS: Dexamethasone significantly inhibited NTHi induced TNF-alpha, IL-6 and IL-10 from COPD macrophages but, CXCL8 was not suppressed. nthi 47-51 interleukin 6 Homo sapiens 71-75 28383530-9 2017 Decarine showed anti-inflammatory activity on human colon cells by reducing IL-6 and IL-8 production in TNF-alpha+IL-1beta-induced Caco-2 cells. Decarine 0-8 interleukin 6 Homo sapiens 76-80 28539744-0 2017 Biological Effects of Hesperetin on Interleukin-6/Phosphorylated Signal Transducer and Activator of Transcription 3 Pathway Signaling in Prostate Cancer PC3 Cells. hesperetin 22-32 interleukin 6 Homo sapiens 36-49 28539744-3 2017 OBJECTIVE: This study was carried out to evaluate the biological effects of hesperetin on the IL-6 gene expression and phosphorylated STAT3, AKT, and ERK1/2 signaling pathways in PC3 prostate cancer (PC) cells. hesperetin 76-86 interleukin 6 Homo sapiens 94-98 28539744-9 2017 IL-6 gene expression, as well as protein level, significantly increased (P < 0.05) in a dose-dependent pattern in treated PC3 with hesperetin compared to the control cells. hesperetin 134-144 interleukin 6 Homo sapiens 0-4 28539744-14 2017 SUMMARY: This study evaluates biological effects of hesperetin on the cell cycle, interleukin-6 gene expression and some phosphorylated signaling pathways in PC3 prostate cancer cells. hesperetin 52-62 interleukin 6 Homo sapiens 82-95 28539744-15 2017 Hesperetin resulted in the inhibition of cell proliferation via inducing G0/G1 phase arrest in spite of the elevation of interleukin-6 gene expression and phosphorylated AKT, STAT3, and ERK1/2 intracellular signaling proteins. hesperetin 0-10 interleukin 6 Homo sapiens 121-134 27750041-10 2017 Induction of Nrf2 activity by tert-butylhydroquinone (tBHQ) increased both EMT phenotypes and gene expression (N-cadherin, fibronectin, Twist2, Snail, and Slug) repressed by IL-6 neutralizing antibody. 2-tert-butylhydroquinone 30-52 interleukin 6 Homo sapiens 174-178 27750041-10 2017 Induction of Nrf2 activity by tert-butylhydroquinone (tBHQ) increased both EMT phenotypes and gene expression (N-cadherin, fibronectin, Twist2, Snail, and Slug) repressed by IL-6 neutralizing antibody. 2-tert-butylhydroquinone 54-58 interleukin 6 Homo sapiens 174-178 27750041-13 2017 GENERAL SIGNIFICANCE: Targeting Stat3/Nrf2 pathway activated by PSC-secreted IL-6 may provide a novel therapeutic option to improve the prognosis of PDAC. pdac 149-153 interleukin 6 Homo sapiens 77-81 28151872-2 2017 The aim of this study was to elucidate whether serum levels of IL-6 and IL-8 at diagnosis could predict the tumor progression pattern of PDAC, especially in extensive hepatic metastasis.According to the tumor burden of hepatic metastasis at the last follow-up, tumor progression pattern was defined as follows: no or limited (unilobar involvement and 5 or less in the within liver, limited group) and extensive hepatic metastasis (bilobar or more than 5, progressed group). pdac 137-141 interleukin 6 Homo sapiens 63-67 28035387-10 2017 Additionally, levels of IL-6 and IL-8 were significantly decreased by prednisone, ibuprofen and betamethasone. Betamethasone 96-109 interleukin 6 Homo sapiens 24-28 27902467-6 2017 Endogenous IL-6 inhibition in somatotroph MtT/S shRNA stable clones results in decreased SA-beta-gal activity and p16INK4a but increased pRb, proliferation and invasion. monooxyethylene trimethylolpropane tristearate 42-45 interleukin 6 Homo sapiens 11-15 28676732-8 2017 Withaferin A, an anti-inflammatory steroidal lactone, inhibited the IL-6- and TNF-alpha-induced cancer cell invasion and decreased colonosphere formation. Lactones 45-52 interleukin 6 Homo sapiens 68-87 27888719-5 2017 Likewise, FlaA2-induced IL-6 production was found to be attenuated by inhibitors for ERK, p38, and NF-kappaB, but not by JNK inhibitor. flaa2 10-15 interleukin 6 Homo sapiens 24-28 28004013-7 2016 IL-6 (P = 0.003), IL6Ralpha (P = 0.02), gp 130 (P = 0.008) and STAT3 (P = 0.03) were significantly higher in TAH-positive (n = 5) compared with TAH-negative FTs by immunohistochemistry. tah 109-112 interleukin 6 Homo sapiens 0-4 27876813-5 2016 Indispensably, STAT3 transcriptional activation by IL-6 is crucial for the arsenic induced miR-21 increase. Arsenic 75-82 interleukin 6 Homo sapiens 51-55 27591243-13 2016 14,15-EET treatment resulted in a significant reduction in IL-6, IL-8, and MCP-1 secretion, and increased accumulation of Nrf2 and expression of HO-1. 14,15-epoxy-5,8,11-eicosatrienoic acid 0-9 interleukin 6 Homo sapiens 59-63 27632703-0 2016 A bis-malonic acid fullerene derivative significantly suppressed IL-33-induced IL-6 expression by inhibiting NF-kappaB activation. bis-malonic acid fullerene 2-28 interleukin 6 Homo sapiens 79-83 27632703-4 2016 In the present study, we demonstrated that a water-soluble bis-malonic acid fullerene derivative (C60-dicyclopropane-1,1,1",1"-tetracarboxylic acid) markedly diminished the IL-33-induced expression of IL-6 in bone marrow-derived mast cells (BMMC). bis-malonic acid fullerene 59-85 interleukin 6 Homo sapiens 201-205 27256567-9 2016 Although the basal production of IL-1, IL-6, and TNF by monocytes in AUD was compared with HC, the PGN- and LPS-mediated IL-6 and TNF production was increased in AUD. pgn 99-102 interleukin 6 Homo sapiens 121-125 27735939-3 2016 Further studies showed pectolinarigenin inhibited constitutive and interleukin-6-induced STAT3 signaling, diminished the accumulation of STAT3 in the nucleus and blocked STAT3 DNA-binding activity in osteosarcoma cells. pectolinarigenin 23-39 interleukin 6 Homo sapiens 67-80 27104742-11 2016 IL-6 and IL-8 release in unstimulated cultures was higher for CPT-isolated PBMCs compared to Ficoll- and SepMate-isolated PBMCs. sepmate 105-112 interleukin 6 Homo sapiens 0-4 27517680-5 2016 RESULTS: The inflammatory mediators (CRP, IL-6, TNF-alpha) were lower in the FTS group than in the traditional group (P < 0.05) on postoperative day (POD) 1, POD 4, and POD 6, and the immunological indicators (IgG, IgA, C3, C4) of the FTS group were superior to those of the traditional group (P < 0.05) on POD 4 and POD 6. fts 77-80 interleukin 6 Homo sapiens 42-46 27427241-7 2016 The most potent metals, Cd(2+), Zn(2+) and As(3+) induced highest levels of oxidative activity, and ROS appeared to be central in their CXCL8 and IL-6 responses. Arsenic 43-45 interleukin 6 Homo sapiens 146-150 27650973-6 2016 ARbeta blocker, propranolol, inhibited NE-induced IL-6 production and phosphorylation of p38 in SSc fibroblasts. Propranolol 16-27 interleukin 6 Homo sapiens 50-54 27650973-7 2016 NE-induced IL-6 was significantly inhibited by p38 inhibitor, SB203580, suggesting that NE-induced phosphorylation of p38 via ARbeta enhances IL-6 production in SSc fibroblasts. SB 203580 62-70 interleukin 6 Homo sapiens 11-15 27650973-7 2016 NE-induced IL-6 was significantly inhibited by p38 inhibitor, SB203580, suggesting that NE-induced phosphorylation of p38 via ARbeta enhances IL-6 production in SSc fibroblasts. SB 203580 62-70 interleukin 6 Homo sapiens 142-146 27609268-10 2016 Furthermore, lycopene decreased LPS-induced expression of IL-1beta and HO-1 in the hippocampus together with decreasing level of IL-6 and TNF-alpha in the plasma. Lycopene 13-21 interleukin 6 Homo sapiens 129-133 27650613-9 2016 Interfollicular plasma cells were prominent in PC-CD and reactive lymphadenopathies; however, IL-6 expression was significantly increased in PC-CD compared to reactive lymph nodes. pc-cd 141-146 interleukin 6 Homo sapiens 94-98 27251370-6 2016 Clinical and non-clinical evidence supports the view that the usual dose of oseltamivir suppresses pro-inflammatory cytokines such as interferon-gamma, interleukin-6, and tumour necrosis factor-alpha almost completely with partial suppression of viral shedding in human influenza virus infection experiment. Oseltamivir 76-87 interleukin 6 Homo sapiens 152-199 27237110-7 2016 We found that chamomile extract was as effective as sulfasalazine (2 mg/ml) in reducing the production of MPO, 5-HT, IL-6, NF-kB, TNFalpha, PGE2 and 8-iso-PGF2alpha , after inflammatory stimulus. Sulfasalazine 52-65 interleukin 6 Homo sapiens 117-121 27529418-7 2016 Additionally, miR-200c delivered using polyethylenimine (PEI) nanoparticles effectively inhibits IL-6, IL-8 and CCL-5 in primary human periodontal ligament fibroblasts and increases the biomarkers of osteogenic differentiation in human bone marrow mesenchymal stem cells (MSCs), including calcium content, ALP, and Runx2. Polyethyleneimine 39-55 interleukin 6 Homo sapiens 97-101 27529418-7 2016 Additionally, miR-200c delivered using polyethylenimine (PEI) nanoparticles effectively inhibits IL-6, IL-8 and CCL-5 in primary human periodontal ligament fibroblasts and increases the biomarkers of osteogenic differentiation in human bone marrow mesenchymal stem cells (MSCs), including calcium content, ALP, and Runx2. Polyethyleneimine 57-60 interleukin 6 Homo sapiens 97-101 27300134-12 2016 In addition, palmitic acid-induced IL-1beta, IL-6, and IL-8 secretion was depended on reactive oxygen species (ROS) generation. Palmitic Acid 13-26 interleukin 6 Homo sapiens 45-49 27300134-13 2016 In conclusion, palmitic acid caused activation of NLRP3 inflammasomes and inflammatory responses, inducing IL-1beta, IL-6, and IL-8 secretion, which is associated with ROS generation, in human Sw.71 placental cells. Palmitic Acid 15-28 interleukin 6 Homo sapiens 117-121 27455316-7 2016 Additionally, the acute inflammatory response (IL-6) was attenuated in the MC group. Methylcholanthrene 75-77 interleukin 6 Homo sapiens 47-51 27270316-9 2016 By inducing the production of G-CSF/IL-6 in vivo, 14,15-EET induced the enhancement of STAT3 activation in neutrophils to increase MMP-9 expression and decrease TRAIL expression. 14,15-epoxy-5,8,11-eicosatrienoic acid 50-59 interleukin 6 Homo sapiens 36-40 27037808-7 2016 Both norepinephrine and dobutamine significantly reduced TNF-alpha and IL-6 production after ex vivo LPS stimulation of whole blood in a dose-dependent manner, and this effect was partially reversed by the presence of metoprolol. Metoprolol 218-228 interleukin 6 Homo sapiens 71-75 26930265-10 2016 Secretion of sFlt-1, sEng, and IL-6 was increased while VEGF and PIGF were decreased in CTB-treated >=150 mg/dl of glucose (*p < 0.01 for each). ctb 88-91 interleukin 6 Homo sapiens 31-35 26953870-14 2016 Patients treated with pioglitazone showed significant decreases in the mean (SD) number of myelin basic protein peptide-specific cells secreting IL-6 and tumor necrosis factor compared with controls (IL-6, 361.6 [80.5] vs 1130.7 [149.21], P < .001; tumor necrosis factor, 189.9 [53.4] vs 341.0 [106.0], P < .001). Pioglitazone 22-34 interleukin 6 Homo sapiens 145-149 26953870-14 2016 Patients treated with pioglitazone showed significant decreases in the mean (SD) number of myelin basic protein peptide-specific cells secreting IL-6 and tumor necrosis factor compared with controls (IL-6, 361.6 [80.5] vs 1130.7 [149.21], P < .001; tumor necrosis factor, 189.9 [53.4] vs 341.0 [106.0], P < .001). Pioglitazone 22-34 interleukin 6 Homo sapiens 200-204 27186296-5 2016 The most likely mechanism is icotinib inhibited the gene expression levels of JAK2, STAT3 and Bcl-2, so with the P-STAT3 and IL-6 protein levels, and mediated gene Bax overexpression. icotinib 29-37 interleukin 6 Homo sapiens 125-129 27001425-9 2016 RESULTS: Compared with patients anaesthetised with sevoflurane, patients who received propofol had higher levels of IL-10 (p = 0.0001) and lower IL-6/IL-10 concentration ratio during and at the end of surgery (p = 0.0001). Propofol 86-94 interleukin 6 Homo sapiens 145-149 25589513-10 2016 RESULTS: Butyrate decreased C16.0+MSU-induced production of IL-1beta, IL-6, IL-8 and IL-1beta mRNA in PBMCs from healthy donors. Butyrates 9-17 interleukin 6 Homo sapiens 70-74 26603372-13 2016 Also, oxygen-glucose deprivation (OGD) reduces TLR3 and IL-6 expression in microglia, but polyinosinic polycytidylic acid (poly-ICLC) rescues TLR3 and IL-6. Poly I-C 90-121 interleukin 6 Homo sapiens 151-155 26603372-13 2016 Also, oxygen-glucose deprivation (OGD) reduces TLR3 and IL-6 expression in microglia, but polyinosinic polycytidylic acid (poly-ICLC) rescues TLR3 and IL-6. Poly I-C 123-132 interleukin 6 Homo sapiens 151-155 26762166-10 2016 Nuomicron association was observed between IL-1beta, IL-6 and MMP-13 expression levels and cartilage defects or patients" age. nuomicron 0-9 interleukin 6 Homo sapiens 53-57 26722842-9 2016 We have found that release of TGF-beta1 and IL-6 was TLR ligand [LPS and Poly(I:C)] concentration dependent and stronger in WJ-EPC than WJ-MSC cultures. Poly I-C 73-82 interleukin 6 Homo sapiens 44-48 26443012-7 2015 Increasing concentrations of PNIPAAM in combination with nanoHA further increased osteoblast proliferation, and decreased IL-6 and LDH production. poly-N-isopropylacrylamide 29-36 interleukin 6 Homo sapiens 122-126 25715004-7 2015 The latanoprost-induced release of IL-6, IL-8, and MCP-1 was attenuated by inhibitors of MAPK (PD98059, SB203580, or JNK inhibitor II) or NF-kappaB (IkappaB kinase 2 inhibitor) signaling pathways. SB 203580 104-112 interleukin 6 Homo sapiens 35-39 26263213-1 2015 In this article, interleukin-6 (IL-6)-conjugated anionic generation 4.5 (G4.5) poly(amidoamine) (PAMAM) was synthesized through EDC/NHS coupling chemistry and evaluated for its optical properties in vitro. Poly(amidoamine) 79-95 interleukin 6 Homo sapiens 17-30 26263213-1 2015 In this article, interleukin-6 (IL-6)-conjugated anionic generation 4.5 (G4.5) poly(amidoamine) (PAMAM) was synthesized through EDC/NHS coupling chemistry and evaluated for its optical properties in vitro. Poly(amidoamine) 79-95 interleukin 6 Homo sapiens 32-36 26263213-1 2015 In this article, interleukin-6 (IL-6)-conjugated anionic generation 4.5 (G4.5) poly(amidoamine) (PAMAM) was synthesized through EDC/NHS coupling chemistry and evaluated for its optical properties in vitro. Poly(amidoamine) 97-102 interleukin 6 Homo sapiens 17-30 26263213-1 2015 In this article, interleukin-6 (IL-6)-conjugated anionic generation 4.5 (G4.5) poly(amidoamine) (PAMAM) was synthesized through EDC/NHS coupling chemistry and evaluated for its optical properties in vitro. Poly(amidoamine) 97-102 interleukin 6 Homo sapiens 32-36 25986659-9 2015 Cinacalcet also elevated expression of the proinflammatory factors IL1beta, IL6 and CCL2. Cinacalcet 0-10 interleukin 6 Homo sapiens 76-79 26104917-2 2015 Previously, we have reported that the cytokine interleukin-6 (IL-6) reduces NMDA-induced cytosolic Ca(2+) overload by inhibiting both L-type voltage-gated calcium channel (L-VGCC) activity and intracellular Ca(2+) store release in cultured cerebellar granule neurons (CGNs). N-Methylaspartate 76-80 interleukin 6 Homo sapiens 47-60 26104917-2 2015 Previously, we have reported that the cytokine interleukin-6 (IL-6) reduces NMDA-induced cytosolic Ca(2+) overload by inhibiting both L-type voltage-gated calcium channel (L-VGCC) activity and intracellular Ca(2+) store release in cultured cerebellar granule neurons (CGNs). N-Methylaspartate 76-80 interleukin 6 Homo sapiens 62-66 26104917-8 2015 AG490, an inhibitor of Janus kinase (JAK), abolished IL-6 protection against extracellular Ca(2+) influx, mitochondrial membrane depolarization, neuronal death, and CaN activity impairment induced by NMDA. N-Methylaspartate 200-204 interleukin 6 Homo sapiens 53-57 26072064-8 2015 Dual treatment of pioglitazone and eplerenone demonstrated synergistic effect on reducing ICAM-1 and IL-6 expression and alleviating NF-kappaB activation when compared with their monotherapies in TNF-alpha activated renal tubular cells. Pioglitazone 18-30 interleukin 6 Homo sapiens 101-105 26072064-9 2015 PPAR-gamma antagonist, GW9662, significantly attenuated protective effect on ICAM-1, IL-6 and PPAR-gamma expression by pioglitazone, eplerenone and their combined treatment. Pioglitazone 119-131 interleukin 6 Homo sapiens 85-89 25888065-0 2015 Upregulated interleukin-6 expression contributes to erlotinib resistance in head and neck squamous cell carcinoma. Erlotinib Hydrochloride 52-61 interleukin 6 Homo sapiens 12-25 25888065-4 2015 Interleukin-6 (IL-6) was one of thirteen genes that was significantly differentially expressed in all erlotinib-resistant HNSCC cell lines, which was validated using RT-PCR and ELISA. Erlotinib Hydrochloride 102-111 interleukin 6 Homo sapiens 0-13 25888065-4 2015 Interleukin-6 (IL-6) was one of thirteen genes that was significantly differentially expressed in all erlotinib-resistant HNSCC cell lines, which was validated using RT-PCR and ELISA. Erlotinib Hydrochloride 102-111 interleukin 6 Homo sapiens 15-19 26138903-8 2015 Honokiol showed an anti-inflammatory effect in PA-inducted HUVECs by significantly inhibiting the generation of interleukin-6 (IL-6), IL-8 and monocyte chemoattractant protein-1. Palmitic Acid 47-49 interleukin 6 Homo sapiens 112-125 26138903-8 2015 Honokiol showed an anti-inflammatory effect in PA-inducted HUVECs by significantly inhibiting the generation of interleukin-6 (IL-6), IL-8 and monocyte chemoattractant protein-1. Palmitic Acid 47-49 interleukin 6 Homo sapiens 127-131 25803620-5 2015 Both intracellular and extracellular poly(I:C) induced the expression of IFNB, TNF, IL6, and IL8. Poly I-C 37-45 interleukin 6 Homo sapiens 84-87 25715050-5 2015 rIFI16 caused dose/time-dependent upregulation of IL-6, IL-8, CCL2, CCL5, CCL20, ICAM1, VCAM1, and TLR4, while secretion of IL-6 and IL-8 was amplified with lipopolysaccharide synergy. rifi16 0-6 interleukin 6 Homo sapiens 50-54 25715050-5 2015 rIFI16 caused dose/time-dependent upregulation of IL-6, IL-8, CCL2, CCL5, CCL20, ICAM1, VCAM1, and TLR4, while secretion of IL-6 and IL-8 was amplified with lipopolysaccharide synergy. rifi16 0-6 interleukin 6 Homo sapiens 124-128 25787755-0 2015 Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells. Anthocyanins 0-12 interleukin 6 Homo sapiens 84-88 25787755-4 2015 In oxLDL-stimulated cells the parent anthocyanin had no effect on IL-6 production, whereas numerous anthocyanin metabolites significantly reduced IL-6 protein levels; phase II conjugates of protocatechuic acid produced the greatest effects (>75% reduction, p <= 0.05). Anthocyanins 100-111 interleukin 6 Homo sapiens 146-150 25787755-5 2015 In CD40L-stimulated cells the anthocyanin and its phase II metabolites reduced IL-6 protein production, where protocatechuic acid-4-sulfate induced the greatest reduction (>96% reduction, p <= 0.03). Anthocyanins 30-41 interleukin 6 Homo sapiens 79-83 25389358-10 2015 CpdA, similarly to prednisolone, down-regulated endogenous and TNF-alpha-induced IL-6, IL-8, MMP-1 and MMP-3 protein secretion. CPDA 0-4 interleukin 6 Homo sapiens 81-85 25389358-11 2015 The dissociative effect of CpdA was confirmed using chondrocytes with no induction of leptin secretion, but with a significant decrease in IL-6, IL-8, MMP-1 and MMP-3 protein secretion. CPDA 27-31 interleukin 6 Homo sapiens 139-143 25358442-7 2015 RESULTS: Dexamethasone reduced LPS-induced TNFalpha, IL-6 and CXCL-8 in all groups, but maximum inhibition was significantly reduced for GINA3/4 compared with GINA2 and GINA1 (P < 0.01). lps 31-34 interleukin 6 Homo sapiens 53-57 25743243-8 2015 Betamethasone reduced the production of the pro-inflammatory cytokines IL-6, IL-12p40, MIP-1alpha and TNF and increased the expression of the anti-inflammatory cytokine IL-10, depending on the pathogen used for stimulation. Betamethasone 0-13 interleukin 6 Homo sapiens 71-75 25862239-7 2015 By using TECO, there was a significant relationship between serum sclerostin, and calcitonin (r = 0.224), IL-6 (r = 0.251) and FGF23 (r = 0.331) levels while no correlation was found with PTH or total alkaline phosphatase. teco 9-13 interleukin 6 Homo sapiens 106-110 25712126-12 2015 Overall, the IL1alpha/IL1R/MYD88/IL6 pathway may be responsible for the reduced antitumor efficacy of erlotinib and other EGFRIs, and blockade of IL1 signaling may improve the efficacy of EGFRIs in the treatment of HNSCC. Erlotinib Hydrochloride 102-111 interleukin 6 Homo sapiens 33-36 25636517-3 2015 In our study, we observed that IL-6 induced the resistance of CLL cells to pan-histone deacetylase (HDAC) inhibitors vorinostat (SAHA) and panobinostat (LBH589). Vorinostat 117-127 interleukin 6 Homo sapiens 31-35 25636517-3 2015 In our study, we observed that IL-6 induced the resistance of CLL cells to pan-histone deacetylase (HDAC) inhibitors vorinostat (SAHA) and panobinostat (LBH589). Vorinostat 129-133 interleukin 6 Homo sapiens 31-35 25636517-3 2015 In our study, we observed that IL-6 induced the resistance of CLL cells to pan-histone deacetylase (HDAC) inhibitors vorinostat (SAHA) and panobinostat (LBH589). Panobinostat 139-151 interleukin 6 Homo sapiens 31-35 25636517-3 2015 In our study, we observed that IL-6 induced the resistance of CLL cells to pan-histone deacetylase (HDAC) inhibitors vorinostat (SAHA) and panobinostat (LBH589). Panobinostat 153-159 interleukin 6 Homo sapiens 31-35 25636517-4 2015 Furthermore, low concentrations of SAHA and LBH589 enhanced the activation of the signal transducer and activator of transcription 3 (STAT3) signaling pathway induced by IL-6 in CLL cells. Vorinostat 35-39 interleukin 6 Homo sapiens 170-174 25636517-4 2015 Furthermore, low concentrations of SAHA and LBH589 enhanced the activation of the signal transducer and activator of transcription 3 (STAT3) signaling pathway induced by IL-6 in CLL cells. Panobinostat 44-50 interleukin 6 Homo sapiens 170-174 25636517-10 2015 Moreover, WP1066 reversed the resistance of CLL cells to SAHA and LBH589 induced by either IL-6 or co-culture with BMSCs. Vorinostat 57-61 interleukin 6 Homo sapiens 91-95 25636517-10 2015 Moreover, WP1066 reversed the resistance of CLL cells to SAHA and LBH589 induced by either IL-6 or co-culture with BMSCs. Panobinostat 66-72 interleukin 6 Homo sapiens 91-95 25689951-6 2015 RESULTS: Following treatment of adipocytes with osthole 0.1-1.6 muM, the TNF-alpha and IL-6 levels in cultured supernatants were decreased, and the NF-kappaB p65 protein expression in adipocytes was also decreased, while the PPARalpha/gamma protein expressions were increased. osthol 48-55 interleukin 6 Homo sapiens 87-91 25689951-7 2015 After pretreatment of adipocytes with specific inhibitor(s) of PPARalpha and /or PPARgamma, the inhibitory effects of osthole on TNF-alpha and IL-6 were decreased or almost cancelled, and the effects on NF-kappaB p65 protein expression also exhibited similar variations. osthol 118-125 interleukin 6 Homo sapiens 143-147 25689951-8 2015 CONCLUSION: Osthole could inhibit the TNF-alpha and IL-6 production in LPS-stimulated adipocytes, and its mechanism might be related to reduction of NF-kappaB expression via activation of PPARalpha/gamma. osthol 12-19 interleukin 6 Homo sapiens 52-56 25889552-3 2015 The aim of this study was to determine whether the intake of an anthocyanin-rich maqui extract improved H2O2 and IL-6 concentrations in exhaled breath condensates (EBCs) from asymptomatic smokers. Anthocyanins 64-75 interleukin 6 Homo sapiens 113-117 25403159-4 2015 Sesaminol also inhibited the expression of IL-8 and IL-6 mRNA following CSE exposure. sesaminol 0-9 interleukin 6 Homo sapiens 52-56 25688664-5 2015 Sulfasalazine dose-dependently inhibited tumor necrosis factor alpha, interleukin 1 (IL-1) beta, IL-2, IL-6, interferon gamma (IFNgamma), and various chemotactic cytokines from SEB-stimulated human PBMC. Sulfasalazine 0-13 interleukin 6 Homo sapiens 103-107 24980460-12 2015 IL-6 and tumour necrosis factor-alpha were preferentially expressed in Aldara-treated skin. Imiquimod 71-77 interleukin 6 Homo sapiens 0-37 25239226-6 2015 Induction of IL-6 production by IL-1beta was significantly reduced by addition of p38 MAPK (SB203580), MEK1/2 (U0126) or NF-kappaB (BAY11-7082) inhibitors, with the highest effect being observed with SB203580. SB 203580 92-100 interleukin 6 Homo sapiens 13-17 25239226-6 2015 Induction of IL-6 production by IL-1beta was significantly reduced by addition of p38 MAPK (SB203580), MEK1/2 (U0126) or NF-kappaB (BAY11-7082) inhibitors, with the highest effect being observed with SB203580. SB 203580 200-208 interleukin 6 Homo sapiens 13-17 25239226-8 2015 Results showed that IL-6 promoter activity of the parent pIL-6-Luc651 was significantly enhanced by IL-1beta, but the level was significantly attenuated by SB203580. SB 203580 156-164 interleukin 6 Homo sapiens 20-24 26510263-6 2015 After 24 hours, compared to the isoflurane group, the propofol group had significantly lower levels of CRP (P < 0.001), IL-6 (P < 0.001) and IL-8 (P < 0.001), with higher levels CD11 (P = 0.009) and CD18 (P = 0.002) expression. Propofol 54-62 interleukin 6 Homo sapiens 123-127 25387665-5 2015 RESULTS: JTE-052 inhibited the JAK1, JAK2, JAK3, and tyrosine kinase (Tyk)2 enzymes in an adenosine triphosphate (ATP)-competitive manner and inhibited cytokine signaling evoked by IL-2, IL-6, IL-23, granulocyte/macrophage colony-stimulating factor, and IFN-alpha. delgocitinib 9-16 interleukin 6 Homo sapiens 187-191 26016511-5 2015 RESULTS: When HUVEC were exposed to PA, there was an increase in the expression of adhesion molecule, cytokines, and inflammatory protein (ICAM-1, MCP-1, interleukin-6, PTX3). Palmitic Acid 36-38 interleukin 6 Homo sapiens 154-167 26016511-9 2015 EPA suppressed the PA-induced increase in the expression of ACSL and p21, the enhancement of p65 phosphorylation, as well as the associated increase in the expression of ICAM-1, MCP-1, interleukin-6, and PTX3. Palmitic Acid 1-3 interleukin 6 Homo sapiens 185-198 25938426-4 2015 The results of MTT assay indicated that HEK 293 cells were more sensitive than HSF to quaternary ammonium pyridoxine derivatives. monooxyethylene trimethylolpropane tristearate 15-18 interleukin 6 Homo sapiens 79-82 25433952-16 2015 CONCLUSION: Patients with POEMS syndrome treated with aPBSCT have significant improvement in PFTs, respiratory muscle strength, imaging, and post-transplant IL-6. apbsct 54-60 interleukin 6 Homo sapiens 157-161 25608815-4 2015 The results showed that, most of the cytokines or receptors had obvious expression change compared with the control (without Poly I:C stimulation), especially the three cytokine genes IL6, IL8 and IL10, whose average expression change times were 20.71, 10.87 and 5.18, respectively. Poly I-C 125-133 interleukin 6 Homo sapiens 184-187 25559834-8 2014 RESULTS: Interleukin 6 levels were significantly higher in propofol than in sevoflurane group (P=0.014). Propofol 59-67 interleukin 6 Homo sapiens 9-22 24954857-12 2014 The p38-MAPK inhibitor SB203580 abolished the IL-6-induced WNT5A up-regulation and blocked IL-6-induced melanoma cell invasion. SB 203580 23-31 interleukin 6 Homo sapiens 46-50 24954857-12 2014 The p38-MAPK inhibitor SB203580 abolished the IL-6-induced WNT5A up-regulation and blocked IL-6-induced melanoma cell invasion. SB 203580 23-31 interleukin 6 Homo sapiens 91-95 24937205-8 2014 Of interest, heart rate was possibly lower with ALA than PLA at 20- (-2.7 +- 3.4%) and 120-min (-1.7 +- 2.9%) of constant-load cycling and the serum interleukin-6 (IL-6) response to 120 min of cycling was likely attenuated with PRO compared with PLA (PLA, 6.6 +- 3.7 fold vs. ala 48-51 interleukin 6 Homo sapiens 164-168 25109475-10 2014 Furthermore, valsartan reduced inflammatory cytokine (TNF-alpha, IL-6 and IL-1beta) production and NF-kappaB activity in HG-activated THP-1 cells. Valsartan 13-22 interleukin 6 Homo sapiens 65-69 25271853-8 2014 Addition of IL-6 to the same cells after stimulation with poly(I-C), CpG, Pam2CSK4, and MDP induced a significant increase in IL-1beta and CXCL8, but not TNF-alpha production compared with TLR ligands alone. Poly I-C 58-67 interleukin 6 Homo sapiens 12-16 25251539-7 2014 Finally, 9-S-HODE, 9-R-HODE, 13-R-HODE, or LPC inhibited the release of IL-6 from monocytes suggesting that these lipids may play important role in controlling inflammatory responses. 13-hydroxy-9,11-octadecadienoic acid 29-38 interleukin 6 Homo sapiens 72-76 25001017-6 2014 Celcoxib also decreased the gene expression of interleukin 6, tumor necrosis factor alpha, collagen A, fibronectin, platelet-derived growth factor, epidermal growth factor, and transforming growth factor beta. celcoxib 0-8 interleukin 6 Homo sapiens 47-89 24881575-5 2014 High-glucose administration increased the level of tumor necrosis factor alpha (TNF-alpha) and IL-6, induced oxidative stress and apoptosis of hippocampal neurons in vitro. high-glucose 0-12 interleukin 6 Homo sapiens 95-99 24746556-8 2014 Demethylation experiments using 5-aza-2"-deoxycytidine (AZA) followed by LPS stimulation revealed a significant enhanced IL-6 mRNA expression and protein release by HL-60 cells. Decitabine 32-54 interleukin 6 Homo sapiens 121-125 24746556-8 2014 Demethylation experiments using 5-aza-2"-deoxycytidine (AZA) followed by LPS stimulation revealed a significant enhanced IL-6 mRNA expression and protein release by HL-60 cells. Decitabine 56-59 interleukin 6 Homo sapiens 121-125 24746556-9 2014 AZA treatment resulted in significant increased IL-6 promoter accessibilities, identifying methylation as an important repressor of IL-6 gene regulation in promyeloid cells. Decitabine 0-3 interleukin 6 Homo sapiens 48-52 24746556-9 2014 AZA treatment resulted in significant increased IL-6 promoter accessibilities, identifying methylation as an important repressor of IL-6 gene regulation in promyeloid cells. Decitabine 0-3 interleukin 6 Homo sapiens 132-136 25038821-12 2014 Treatment with sesamin significantly reduced the expression of nuclear NF-kappaB, IL-6, p-Stat3, Twist and Vimentin (a mesenchymal marker) in SP cells. sesamin 15-22 interleukin 6 Homo sapiens 82-86 25038821-13 2014 Nuclear NF-kappaB activity and IL-6 level were also decreased after treatment with sesamin. sesamin 83-90 interleukin 6 Homo sapiens 31-35 25038821-14 2014 CONCLUSION: Food-derived sesamin directs the epithelial differentiation of cancer stem-like SP cells from GBC, which is associated with attenuation of NF-kappaB-IL-6-Stat3-Twist signal pathway. sesamin 25-32 interleukin 6 Homo sapiens 161-165 24662521-7 2014 High-glucose conditions further enhanced the tumour-driven macrophage enrichment and associated interleukin (IL)-6 and IL-8 cytokine levels. high-glucose 0-12 interleukin 6 Homo sapiens 96-114 24576880-6 2014 The cell types tested, except HSF, are able to convert inactive 25-hydroxyvitamin D3 (25[OH]D3) into active 1,25-hydroxyvitamin D3 (1,25[OH]2D3). Calcifediol 64-84 interleukin 6 Homo sapiens 30-33 24551118-18 2014 Together, our studies imply that autophagy is involved in PCa progression and plays a cytoprotective role when NED is induced in PCa cells by IL-6 treatment. ned 111-114 interleukin 6 Homo sapiens 142-146 24390544-5 2014 Treatment of macrophages with n-butyrate led to the down-regulation of lipopolysaccharide-induced proinflammatory mediators, including nitric oxide, IL-6, and IL-12, but did not affect levels of TNF-alpha or MCP-1. Butyrates 30-40 interleukin 6 Homo sapiens 149-153 24128422-2 2014 We investigated the effect of lipopolysacharide (LPS) and progesterone (P4) upon expression of TLR-4/MyD88, TNFalpha, IL-6, IL-8, IL-10, and HBD2 on the human amniotic epithelium. lps 49-52 interleukin 6 Homo sapiens 118-122 24995301-1 2014 The study was designed to determine the effects of peripheral injection of SB203580 on the synthesis of interleukin- (IL-) 1beta, IL-6, and tumor necrosis factor (TNF) alpha in the hypothalamus of ewes during prolonged inflammation. SB 203580 75-83 interleukin 6 Homo sapiens 130-134 24995301-3 2014 SB203580 is a selective ATP-competitive inhibitor of the p38 mitogen-activated protein kinase (MAPK), which is involved in the regulation of proinflammatory cytokines IL-1beta, IL-6 and TNFalpha synthesis. SB 203580 0-8 interleukin 6 Homo sapiens 177-181 24995301-4 2014 Intravenous injection of SB203580 successfully inhibited (P < 0.01) synthesis of IL-1beta and reduced (P < 0.01) the production of IL-6 in the hypothalamus. SB 203580 25-33 interleukin 6 Homo sapiens 137-141 24048704-7 2013 Inhibitors of NF-kappaB, p38, and JNK suppressed erlotinib-induced IL-6 expression, suggesting critical roles for NF-kappaB and MAPK in IL-6 regulation. Erlotinib Hydrochloride 49-58 interleukin 6 Homo sapiens 67-71 24048704-7 2013 Inhibitors of NF-kappaB, p38, and JNK suppressed erlotinib-induced IL-6 expression, suggesting critical roles for NF-kappaB and MAPK in IL-6 regulation. Erlotinib Hydrochloride 49-58 interleukin 6 Homo sapiens 136-140 23921144-8 2013 To further elucidate the regulatory mechanism whereby PA amplifies LPS signal, our studies showed that PA and LPS synergistically increased hydrolysis of sphingomyelin by stimulating acid sphingomyelinase (ASMase) activity, which contributed to a marked increase in ceramide production and IL-6 upregulation. Palmitic Acid 54-56 interleukin 6 Homo sapiens 290-294 23921144-8 2013 To further elucidate the regulatory mechanism whereby PA amplifies LPS signal, our studies showed that PA and LPS synergistically increased hydrolysis of sphingomyelin by stimulating acid sphingomyelinase (ASMase) activity, which contributed to a marked increase in ceramide production and IL-6 upregulation. Palmitic Acid 103-105 interleukin 6 Homo sapiens 290-294 23982484-0 2013 Lenalidomide overcomes suppression of human natural killer cell anti-tumor functions by neuroblastoma microenvironment-associated IL-6 and TGFbeta1. Lenalidomide 0-12 interleukin 6 Homo sapiens 130-134 23982484-8 2013 Lenalidomide blocks IL-6 and TGFbeta1 activation of these signaling pathways and inhibits their suppression of NK cells. Lenalidomide 0-12 interleukin 6 Homo sapiens 20-24 23982484-11 2013 CONCLUSION: Immunotherapy with anti-tumor cell antibodies may be improved by lenalidomide, which enhances activation of NK cells and inhibits their suppression by IL-6 and TGFbeta1. Lenalidomide 77-89 interleukin 6 Homo sapiens 163-167 24157160-16 2013 CONCLUSION: IL-6 or TNF-alpha may serve as potential predictive biomarker for the efficacy of erlotinib. Erlotinib Hydrochloride 94-103 interleukin 6 Homo sapiens 12-16 23793449-7 2013 In the propofol group, IL-6 and IL-8 were significantly increased at T3 compared to T1. Propofol 7-15 interleukin 6 Homo sapiens 23-27 23768126-7 2013 Furthermore, poly I:C or CpG encapsulated in Ac-DEX also showed, in general, a significantly stronger immunostimulatory response than PLGA and unencapsulated CpG or poly I:C, which was indicated by a higher rate of nitric oxide release and increased levels of cytokines such as TNF-alpha, IL-6, IL-10, and IFN-gamma. Poly I-C 13-21 interleukin 6 Homo sapiens 289-293 23768126-7 2013 Furthermore, poly I:C or CpG encapsulated in Ac-DEX also showed, in general, a significantly stronger immunostimulatory response than PLGA and unencapsulated CpG or poly I:C, which was indicated by a higher rate of nitric oxide release and increased levels of cytokines such as TNF-alpha, IL-6, IL-10, and IFN-gamma. ac-dex 45-51 interleukin 6 Homo sapiens 289-293 23324897-4 2013 Both atorvastatin and vitamin E showed a statistically significant GPO increase (P<0.05) and a statistically significant IL-6 decrease (P<0.05). Vitamin E 22-31 interleukin 6 Homo sapiens 124-128 23650978-0 2013 Tocilizumab: a novel humanized anti-interleukin 6 (IL-6) receptor antibody for the treatment of patients with non-RA systemic, inflammatory rheumatic diseases. Radium 114-116 interleukin 6 Homo sapiens 31-49 23577829-9 2013 In addition, HDAC inhibitors significantly inhibited poly (I:C)-induced IL-6 production in both of the epithelial cells. Poly I-C 53-63 interleukin 6 Homo sapiens 72-76 23276728-6 2013 CS inhibited NF-kappaB activation and the release of some of the key psoriatic cytokines such as TNFalpha, IL-8, IL-6 and CCL27. Chondroitin Sulfates 0-2 interleukin 6 Homo sapiens 113-117 23161148-0 2013 Neuroprotection of interleukin-6 against NMDA-induced neurotoxicity is mediated by JAK/STAT3, MAPK/ERK, and PI3K/AKT signaling pathways. N-Methylaspartate 41-45 interleukin 6 Homo sapiens 19-32 23161148-1 2013 We have previously shown that interleukin-6 (IL-6) has neuroprotective effect against N-methyl-D-aspartate (NMDA)-induced excitotoxicity. N-Methylaspartate 86-106 interleukin 6 Homo sapiens 30-43 23161148-1 2013 We have previously shown that interleukin-6 (IL-6) has neuroprotective effect against N-methyl-D-aspartate (NMDA)-induced excitotoxicity. N-Methylaspartate 86-106 interleukin 6 Homo sapiens 45-49 23397947-0 2013 Nicotinamide downregulates gene expression of interleukin-6, interleukin-10, monocyte chemoattractant protein-1, and tumour necrosis factor-alpha gene expression in HaCaT keratinocytes after ultraviolet B irradiation. Niacinamide 0-12 interleukin 6 Homo sapiens 46-59 23397947-3 2013 In this study we investigated whether nicotinamide (NCT), the amide form of vitamin B3, might have a protective function in reducing the expression of interleukin (IL)-1beta, IL-6, IL-8, IL-10, monocyte chemoattractant protein (MCP)-1 and tumour necrosis factor (TNF)-alpha in UV-irradiated keratinocytes. Niacinamide 38-50 interleukin 6 Homo sapiens 175-179 23397947-3 2013 In this study we investigated whether nicotinamide (NCT), the amide form of vitamin B3, might have a protective function in reducing the expression of interleukin (IL)-1beta, IL-6, IL-8, IL-10, monocyte chemoattractant protein (MCP)-1 and tumour necrosis factor (TNF)-alpha in UV-irradiated keratinocytes. Niacinamide 76-86 interleukin 6 Homo sapiens 175-179 23343403-14 2013 CCN4-mediated IL-6 production was attenuated by PI3K inhibitor (LY294002 and Wortmannin), Akt inhibitor (Akti), and NF-kappaB inhibitor (PDTC and TPCK). Wortmannin 77-87 interleukin 6 Homo sapiens 14-18 23142265-9 2013 IL-6(-597/-572/-174) haplotypes GGG, GCG, and AGC comprised 99.74% of the total haplotypes. gallocatechin gallate 37-40 interleukin 6 Homo sapiens 0-4 22990668-8 2013 RESULTS: Treatment of RA FLS with GW3965 induced dose-dependent reductions in mRNA expression of pro-inflammatory mediators (IL-1beta, IL-6, MMP-9, CCL-2, CCL-7, and COX-2). GW 3965 34-40 interleukin 6 Homo sapiens 135-139 24078775-0 2013 Palmitic acid induces production of proinflammatory cytokines interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha via a NF-kappaB-dependent mechanism in HaCaT keratinocytes. Palmitic Acid 0-13 interleukin 6 Homo sapiens 62-75 24078775-4 2013 Our results showed that palmitic acid induced an upregulation of IL-6, TNF- alpha , IL-1 beta secretions, accompanied by NF- kappa B nuclear translocation and activation. Palmitic Acid 24-37 interleukin 6 Homo sapiens 65-69 24078775-6 2013 Palmitic acid-induced IL-6, TNF- alpha , IL-1 beta productions were attenuated by NF- kappa B inhibitor PDTC. Palmitic Acid 0-13 interleukin 6 Homo sapiens 22-26 24078775-7 2013 Palmitic acid was administered in amounts able to elicit significant hyperproliferation and can be attenuated by IL-6 blockage. Palmitic Acid 0-13 interleukin 6 Homo sapiens 113-117 24078775-8 2013 These data demonstrate for the first time that palmitic acid can stimulate IL-6, TNF- alpha , IL-1 beta productions in HaCaT keratinocytes and cell proliferation, thereby potentially contributing to acne inflammation and pilosebaceous duct hyperkeratinization. Palmitic Acid 47-60 interleukin 6 Homo sapiens 75-79 24459828-10 2013 Stimulation with PolyI:C, Pam3CSK4 and LPS also lead to considerable increase of NF-kBp65, while increased levels of inflammatory cytokines were observed for IL-8, TNF and IL-6 in cells treated with PMA and MeV. Poly I-C 17-24 interleukin 6 Homo sapiens 172-176 22961265-6 2012 Inhibition of NO production (with l-NAME) resulted in upregulation of IRB-induced diaphragmatic IL-6, IL-10, IL-2, TNF-alpha, and IL-1beta levels by 50%, 53%, 60%, 47%, and 45%, respectively. NG-Nitroarginine Methyl Ester 34-40 interleukin 6 Homo sapiens 96-100 22961265-9 2012 NF-kappaB and ERK1/2 inhibition in l-NAME-treated animals blunted the l-NAME-induced cytokine upregulation except IL-6, whereas P38 inhibition blunted all (including IL-6) cytokine upregulation. NG-Nitroarginine Methyl Ester 35-41 interleukin 6 Homo sapiens 114-118 22961265-9 2012 NF-kappaB and ERK1/2 inhibition in l-NAME-treated animals blunted the l-NAME-induced cytokine upregulation except IL-6, whereas P38 inhibition blunted all (including IL-6) cytokine upregulation. NG-Nitroarginine Methyl Ester 35-41 interleukin 6 Homo sapiens 166-170 22883023-8 2012 Serum levels of IL6 and IL8 also increased in the arsenic exposed group. Arsenic 50-57 interleukin 6 Homo sapiens 16-19 22703874-4 2012 Results showed that LPS-induced adipose stem cell secretion of IL-6 reduced with the addition of tart cherry extract, a mixture of tart cherry anthocyanins, and pure tart cherry cyanidin-3-O-glucoside (C3G) in a dose-dependent manner. Anthocyanins 143-155 interleukin 6 Homo sapiens 63-67 22507133-0 2012 Anti-fibrotic activity and enhanced interleukin-6 production by hepatic stellate cells in response to imatinib mesylate. Imatinib Mesylate 102-119 interleukin 6 Homo sapiens 36-49 22507133-7 2012 cDNA microarray uncovered up-regulation of 29 genes in response to imatinib, including interleukin-6 (IL-6) mRNA, which was correlated with progressive IL-6 secretion. Imatinib Mesylate 67-75 interleukin 6 Homo sapiens 87-100 22507133-7 2012 cDNA microarray uncovered up-regulation of 29 genes in response to imatinib, including interleukin-6 (IL-6) mRNA, which was correlated with progressive IL-6 secretion. Imatinib Mesylate 67-75 interleukin 6 Homo sapiens 102-106 22507133-7 2012 cDNA microarray uncovered up-regulation of 29 genes in response to imatinib, including interleukin-6 (IL-6) mRNA, which was correlated with progressive IL-6 secretion. Imatinib Mesylate 67-75 interleukin 6 Homo sapiens 152-156 22507133-10 2012 Importantly, hepatic IL-6 mRNA levels were significantly increased in TAA-treated animals receiving imatinib. Imatinib Mesylate 100-108 interleukin 6 Homo sapiens 21-25 22851938-11 2012 CONCLUSION: Our data indicate that the induction of eTPO synthesis by IL-6 may be a potential mechanism in which IVIg may stimulate thrombopoiesis. etpo 52-56 interleukin 6 Homo sapiens 70-74 22226662-9 2012 Also, changes in plasma total carotenoid and lycopene concentration were inversely correlated with the changes in IL-6 production in LPS-activated PBMCs. Lycopene 45-53 interleukin 6 Homo sapiens 114-118 22690149-5 2012 ELISA measurement suggested that ASTA treatment (10 microM) reduced pro-inflammatory cytokines secretion (IL-1beta, IL-6 and TNF-alpha) induced through H(2)O(2), (100 microM). Cyclophosphamide 33-37 interleukin 6 Homo sapiens 116-120 22452847-4 2012 In the present study, the relevance of the PKA activity and two PKA-activating drugs, aminophylline and adrenaline, to LPS-induced inflammatory cytokines (IL-6 and IL-8) and PGE2 by HGFs were examined. Epinephrine 104-114 interleukin 6 Homo sapiens 155-159 22116002-6 2012 Poly(I:C) stimulated the secretion of IL-6, IL-8, MCP-1, RANTES, IP-10, eotaxin, MIP-1beta, and interferon-gamma, whereas zymosan triggered the production of IL-6, IL-8, and MCP-1. Poly I-C 0-8 interleukin 6 Homo sapiens 38-42 22116002-6 2012 Poly(I:C) stimulated the secretion of IL-6, IL-8, MCP-1, RANTES, IP-10, eotaxin, MIP-1beta, and interferon-gamma, whereas zymosan triggered the production of IL-6, IL-8, and MCP-1. Poly I-C 0-8 interleukin 6 Homo sapiens 158-162 22116002-7 2012 LPS, poly(I:C), and zymosan thus each induced a distinct pattern of cytokine and chemokine release from human corneal fibroblasts, with the release of IL-6, IL-8, and MCP-1 being commonly elicited by all three agents. Poly I-C 5-14 interleukin 6 Homo sapiens 151-155 22281490-8 2012 Most importantly, human cell-based assays revealed that Vitamin E significantly inhibits rhMIF-induced production of pro-inflammatory cytokines in a dose-dependent manner (77%, 80%, and 96% inhibition of IL-6 production, respectively, at 10, 30 and 100muM). Vitamin E 56-65 interleukin 6 Homo sapiens 204-208 21917119-8 2012 Depleting both IL-6 and IL-8 completely reversed the effect of NP-BEAS-2B-CM- and NP-HBE-CM-mediated BSMC proliferation and migration, suggesting that this effect is a synergistic influence of IL-6 and IL-8. bsmc 101-105 interleukin 6 Homo sapiens 15-19 22154514-5 2012 The levels of IL-6 were significantly higher in the aMCI group than in controls (P<0.01). amci 52-56 interleukin 6 Homo sapiens 14-18 22154514-6 2012 When the aMCI group was stratified by APOEepsilon4 status, significant differences were found between the low- and high-risk groups and controls in the levels of IL-6 and IFN-gamma (P<0.01 and P=0.041, respectively). amci 9-13 interleukin 6 Homo sapiens 162-166 22154514-7 2012 Moreover, the IL-6 level in the low-risk aMCI group was higher than that in the high-risk aMCI group (P=0.028). amci 41-45 interleukin 6 Homo sapiens 14-18 22154514-7 2012 Moreover, the IL-6 level in the low-risk aMCI group was higher than that in the high-risk aMCI group (P=0.028). amci 90-94 interleukin 6 Homo sapiens 14-18 22158433-8 2012 Valsartan and ramipril both lowered IL-6 levels during dialysis (P<0.01 for each compared with placebo). Valsartan 0-9 interleukin 6 Homo sapiens 36-40 22158433-8 2012 Valsartan and ramipril both lowered IL-6 levels during dialysis (P<0.01 for each compared with placebo). Ramipril 14-22 interleukin 6 Homo sapiens 36-40 22110547-7 2012 In addition, EBNE-induced production of IL-6 and VEGF was inhibited by PD98059 (a p44/42 MAPK inhibitor), SB203580 (a p38 MAPK inhibitor), and PDTC (a NF-kappaB inhibitor), but not SP600125 (a JNK inhibitor). SB 203580 106-114 interleukin 6 Homo sapiens 40-44 22605923-6 2012 Pretreatment with 10(-10) M 17-beta-estradiol greatly inhibited the increased expression and production of IL-6, IL-1, and TNF-alpha induced by hyperosmolarity, whereas with the administration of SB203580 (10 muM), an inhibitor of the p38 pathway, the inhibiting effect of 17-beta-estradiol disappeared. SB 203580 196-204 interleukin 6 Homo sapiens 107-111 23226414-2 2012 Biochemical evidence demonstrates that in primary cortical neurons and SH-SY5Y neuroblastoma cells, IL-6 cytokine family members, OSM and IL-6 plus the soluble IL-6R (IL-6/R), prevent NMDA and glutamate-induced neuronal toxicity. N-Methylaspartate 184-188 interleukin 6 Homo sapiens 100-104 23226414-2 2012 Biochemical evidence demonstrates that in primary cortical neurons and SH-SY5Y neuroblastoma cells, IL-6 cytokine family members, OSM and IL-6 plus the soluble IL-6R (IL-6/R), prevent NMDA and glutamate-induced neuronal toxicity. N-Methylaspartate 184-188 interleukin 6 Homo sapiens 138-142 22514713-4 2012 Our results show that artemisinin significantly inhibited LPS-induced production of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1) and nitric oxide (NO). artemisinin 22-33 interleukin 6 Homo sapiens 125-138 22514713-4 2012 Our results show that artemisinin significantly inhibited LPS-induced production of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1) and nitric oxide (NO). artemisinin 22-33 interleukin 6 Homo sapiens 140-144 21538419-8 2012 Sanguinarine inhibits constitutive as well as IL6-induced phosphorylation of Stat3 at both Tyr705 and Ser727 in prostate cancer cells. sanguinarine 0-12 interleukin 6 Homo sapiens 46-49 21989792-6 2011 Median hs-CRP and IL-6 levels were reduced in both varespladib methyl-treated diabetic and non-diabetic patients, but these differences were not statistically significantly different at 8 weeks (p = 0.57 and p = 0.97 respectively). varespladib 51-62 interleukin 6 Homo sapiens 18-22 21771657-6 2011 In other studies, a non-antimicrobial formulation of doxycycline (SDD) has been found to dramatically reduce hsCRP, IL-6 and MMP-9 levels in plasma of ACS patients, and SDD has also been found to significantly increase serum levels of both cardio-protective HDL cholesterol and its core molecule apolipoprotein A-I in ASCVD-vulnerable patients with periodontitis. SDDS 66-69 interleukin 6 Homo sapiens 116-120 22129063-6 2011 U0126 (MAPK kinase (MEK)1/2 inhibitor) and SB203580 (p38 MAPK inhibitor) decreased the LPS-enhanced release of IL-6 and GM-CSF. SB 203580 43-51 interleukin 6 Homo sapiens 111-115 21854030-9 2011 Finally, in vitro LPS-induced IL-6 production from BEAS-2B was more and longer suppressed by PDSC than prednisolone and PDC. Prednisolone 103-115 interleukin 6 Homo sapiens 30-34 21782151-9 2011 IL-6, IP-10, MCP-1, PDGF-AA, and VEGF were significantly decreased in the IVTA group, but only VEGF in the IVBe group. ivta 74-78 interleukin 6 Homo sapiens 0-4 21708226-7 2011 Moreover, SMC treated with glycol-AGEs also expressed interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1), and the level of cytokines expression was significantly elevated in the co-culture system of HUVEC and THP-1 when treated with glycol-AGEs. Glycols 27-33 interleukin 6 Homo sapiens 54-67 21708226-7 2011 Moreover, SMC treated with glycol-AGEs also expressed interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1), and the level of cytokines expression was significantly elevated in the co-culture system of HUVEC and THP-1 when treated with glycol-AGEs. Glycols 27-33 interleukin 6 Homo sapiens 69-73 21349943-7 2011 EP2 agonist significantly suppressed the polyI:C-induced the expressions of CCL5, CXCL10 and CXCL11 but not of IL-6. polyi:c 41-48 interleukin 6 Homo sapiens 111-115 21540553-0 2011 IL-6 promotes nonthyroidal illness syndrome by blocking thyroxine activation while promoting thyroid hormone inactivation in human cells. Thyroxine 56-65 interleukin 6 Homo sapiens 0-4 20717763-1 2011 We have previously shown that interleukin-6 (IL-6)-protected neurons against the suppression of neuronal vitality and overload of intracellular Ca(2+) induced by glutamate or N-methyl-D: -aspartate (NMDA). N-Methylaspartate 175-197 interleukin 6 Homo sapiens 30-43 20717763-1 2011 We have previously shown that interleukin-6 (IL-6)-protected neurons against the suppression of neuronal vitality and overload of intracellular Ca(2+) induced by glutamate or N-methyl-D: -aspartate (NMDA). N-Methylaspartate 175-197 interleukin 6 Homo sapiens 45-49 20717763-1 2011 We have previously shown that interleukin-6 (IL-6)-protected neurons against the suppression of neuronal vitality and overload of intracellular Ca(2+) induced by glutamate or N-methyl-D: -aspartate (NMDA). N-Methylaspartate 199-203 interleukin 6 Homo sapiens 30-43 20717763-1 2011 We have previously shown that interleukin-6 (IL-6)-protected neurons against the suppression of neuronal vitality and overload of intracellular Ca(2+) induced by glutamate or N-methyl-D: -aspartate (NMDA). N-Methylaspartate 199-203 interleukin 6 Homo sapiens 45-49 20717763-2 2011 Herein we provide further evidence for IL-6 neuroprotection against NMDA-induced apoptosis and explore the signal-transduction mechanisms underlying the anti-apoptotic action of IL-6. N-Methylaspartate 68-72 interleukin 6 Homo sapiens 39-43 20717763-7 2011 After the CGNs were chronically exposed to IL-6, NMDA stimulation led to an increase in the expression of Bcl-2 mRNA and a decrease in the expression of Bax and caspase-3 mRNAs and proteins when compared with those neurons lacking IL-6 exposure. N-Methylaspartate 49-53 interleukin 6 Homo sapiens 43-47 20717763-7 2011 After the CGNs were chronically exposed to IL-6, NMDA stimulation led to an increase in the expression of Bcl-2 mRNA and a decrease in the expression of Bax and caspase-3 mRNAs and proteins when compared with those neurons lacking IL-6 exposure. N-Methylaspartate 49-53 interleukin 6 Homo sapiens 231-235 20717763-8 2011 IL-6 pretreatment of the neurons without NMDA stimulation concentration-dependently enhanced the expressions of Bcl-2 mRNA and protein while attenuating the expressions of Bax and caspase-3 mRNAs and proteins in comparison with control lacking any treatment. N-Methylaspartate 41-45 interleukin 6 Homo sapiens 0-4 20717763-9 2011 Furthermore, IL-6 prevented the increase in the percentage of apoptotic neurons induced by NMDA. N-Methylaspartate 91-95 interleukin 6 Homo sapiens 13-17 20717763-13 2011 These results suggest that IL-6 protects neurons against NMDA-induced apoptosis, and that the IL-6 neuroprotection is jointly mediated by JAK-STAT3 and PI3K-Akt signaling pathways. N-Methylaspartate 57-61 interleukin 6 Homo sapiens 27-31 21408027-4 2011 METHODOLOGY/PRINCIPAL FINDINGS: In the current study we showed, for the first time, that CDF could significantly inhibit the sphere-forming ability (pancreatospheres) of PC cells consistent with increased disintegration of pancreatospheres, which was associated with attenuation of CSC markers (CD44 and EpCAM), especially in gemcitabine-resistant (MIAPaCa-2) PC cells containing high proportion of CSCs consistent with increased miR-21 and decreased miR-200. gemcitabine 326-337 interleukin 6 Homo sapiens 89-92 20674229-1 2011 It is proposed that the significant elevation of interleukin-6 (>400 pg/mL) in cerebrospinal fluid during the early phase of carbon monoxide poisoning may be a predictive biomarker for the development of delayed encephalopathy. Carbon Monoxide 128-143 interleukin 6 Homo sapiens 49-62 20674229-6 2011 Interleukin-6 in cerebrospinal fluid at 5.5 hours after his last exposure to carbon monoxide was significantly elevated (752 pg/mL). Carbon Monoxide 77-92 interleukin 6 Homo sapiens 0-13 21187140-8 2011 These effects were blocked by the beta-adrenergic antagonist propranolol, supporting a role for beta-ARs in IL-6 secretion. Propranolol 61-72 interleukin 6 Homo sapiens 108-112 20645940-7 2011 CONCLUSION: Vitamin E and enoxaparin are able not only to prevent foetal wastage but also to balance IL-6 and VEGF placental levels, presenting a new potential therapeutic alternative for patients with recurrent abortion not associated with thrombophilias. Vitamin E 12-21 interleukin 6 Homo sapiens 101-105 21215621-1 2011 Several thalidomide analogues were synthesized and compared to thalidomide and its more active analogue, lenalidomide, for their ability to inhibit the production of the pro-inflammatory cytokine tumour necrosis factor (TNF)-alpha and interleukin (IL)-6 by LPS-activated peripheral blood mononuclear cells (PBMCs). Lenalidomide 105-117 interleukin 6 Homo sapiens 235-253 21088110-5 2011 Furthermore, excitation-coupled calcium entry induces generation of reactive nitrogen species and enhances nuclear localization of NFATc1, which in turn may be responsible for the increased IL-6 released by myotubes from patients with CCD. Reactive Nitrogen Species 68-93 interleukin 6 Homo sapiens 190-194 20739465-10 2011 Hypertonicity-induced increases in IL-6 and IL-8 releases were suppressed by exposure to capsazepine, AG 1478, ERK inhibitor PD 98059, p38 inhibitor SB 203580, or NF-kappaB inhibitor PDTC. SB 203580 149-158 interleukin 6 Homo sapiens 35-39 21385538-2 2011 The aims of the study were to evaluate serum levels of IL-6 in MC+HCV patients and to correlate this parameter with the presence of AT and with circulating levels of TNF-alpha. Methylcholanthrene 63-65 interleukin 6 Homo sapiens 55-59 21385538-4 2011 RESULTS: MC+HCV patients showed significantly (p<0.01; Mann-Whitney U-test) higher IL-6 (median 8.1ng/l, range 0.7-651) serum levels than controls (median 0.6ng/l, range 0.5-41), or AT (median 2.8ng/l, range 0.5-67). Methylcholanthrene 9-12 interleukin 6 Homo sapiens 86-90 21385538-5 2011 MC+AT showed significantly (p<0.01; Mann-Whitney U-test) higher mean IL-6 (median 15.8ng/l, range 0.5-781) than controls, AT and MC+HCV. Methylcholanthrene 0-3 interleukin 6 Homo sapiens 72-76 21385538-7 2011 CONCLUSIONS: Our study demonstrates significantly higher serum levels of IL-6 and TNF-alpha in patients with MC+HCV and MC+AT compared to healthy controls. Methylcholanthrene 109-112 interleukin 6 Homo sapiens 73-77 21385538-8 2011 Furthermore, the study first shows a significant increase in circulating IL-6 observed in MC+AT patients with respect to MC+HCV. Methylcholanthrene 90-93 interleukin 6 Homo sapiens 73-77 21480818-0 2011 Tumor necrosis factor-alpha and interleukin-6 expression in leukocytes and their association with polymorphisms and bone markers in diabetic individuals treated with pioglitazone. Pioglitazone 166-178 interleukin 6 Homo sapiens 32-45 20631726-6 2010 EGFP-LEDGF-HaCaT cells had increased expression of IL-6, which was attenuated by LEDGF-specific RNA interference and the p38-specific inhibitors SB-239063 and SB-203580. SB 239063 145-154 interleukin 6 Homo sapiens 51-55 20631726-6 2010 EGFP-LEDGF-HaCaT cells had increased expression of IL-6, which was attenuated by LEDGF-specific RNA interference and the p38-specific inhibitors SB-239063 and SB-203580. SB 203580 159-168 interleukin 6 Homo sapiens 51-55 20884048-6 2010 Expression of IDO, TDO, TNFalpha and IL6 mRNAs was increased with LPS treatment, a response mitigated by the presence of sulfasalazine (P<0.01, P<0.01, P=0.03 &P=0.04). Sulfasalazine 121-134 interleukin 6 Homo sapiens 37-40 20537748-3 2010 RESULTS: VAL treatment did not significantly affect serum interleukin-6 (IL-6) or tumor necrosis factor alpha (TNFalpha) levels in the overall study population but significantly reduced serum IL-6 in the subgroup with high inflammatory load at baseline (IL-6>median (2.0 ng/L), n=54: [median, ng/L]): VAL: from 3.5 to 2.4; placebo: from 3.2 to 3.5; p=0.035). Valsartan 9-12 interleukin 6 Homo sapiens 192-196 20537748-3 2010 RESULTS: VAL treatment did not significantly affect serum interleukin-6 (IL-6) or tumor necrosis factor alpha (TNFalpha) levels in the overall study population but significantly reduced serum IL-6 in the subgroup with high inflammatory load at baseline (IL-6>median (2.0 ng/L), n=54: [median, ng/L]): VAL: from 3.5 to 2.4; placebo: from 3.2 to 3.5; p=0.035). Valsartan 9-12 interleukin 6 Homo sapiens 192-196 20421217-9 2010 At similar concentrations, MS-275 and SAHA suppressed LPS-induced NF-kappaB p65 nuclear accumulation and IL-1beta, IL-6, IL-18 and TNF-alpha secretion in THP-1 monocytic cells. Vorinostat 38-42 interleukin 6 Homo sapiens 115-119 20351184-6 2010 The NF-kappaB pathway inhibitor BAY-11, JNK inhibitor JNKi II, and p38 inhibitor SB203580 suppressed the synergistic effect of IL-6 and IL-17 on IL-6 expression. SB 203580 81-89 interleukin 6 Homo sapiens 127-131 20351184-6 2010 The NF-kappaB pathway inhibitor BAY-11, JNK inhibitor JNKi II, and p38 inhibitor SB203580 suppressed the synergistic effect of IL-6 and IL-17 on IL-6 expression. SB 203580 81-89 interleukin 6 Homo sapiens 145-149 20429644-12 2010 CONCLUSION: These results suggest that the disease activity of RA correlated with serum levels of IL-6, TNF-alpha, and CRP, and it might influence BOP in the patients with moderate to high disease activity. bop 147-150 interleukin 6 Homo sapiens 98-102 20205737-12 2010 There was no difference in TNF and IL-2 concentrations, but plasma IFN-gamma and IL-6 increased on wk 8 in subjects given 8 mg astaxanthin. astaxanthine 127-138 interleukin 6 Homo sapiens 81-85 20131233-9 2010 Increased expression of tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and IL-6 induced by lipopolysaccharide was attenuated by cilostazol and CoPP, and this was reversed by ZnPP. Cilostazol 151-161 interleukin 6 Homo sapiens 98-102 20131233-9 2010 Increased expression of tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and IL-6 induced by lipopolysaccharide was attenuated by cilostazol and CoPP, and this was reversed by ZnPP. zinc protoporphyrin 197-201 interleukin 6 Homo sapiens 98-102 20034529-8 2010 In this setting, poly(I:C) further augments IL-6, IL-12p35, IL-23p19, and IL-27p28 transcription, whereas lipopolysaccharide (LPS) increases IL-23p19 and IL-27p28 transcription. Poly I-C 17-26 interleukin 6 Homo sapiens 44-48 20004742-5 2010 While inhibition of the expression of the TNF-alpha gene was mediated predominantly by the alpha-bungarotoxin sensitive nAChRs, that of the IL-6 and IL-18 genes-by the mecamylamine-sensitive nAChRs. nachrs 191-197 interleukin 6 Homo sapiens 140-144 20427039-2 2010 Our data show for the first time that NK cells produce high levels of cytokines interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in response to stimulation with the artificial RNA analogue Poly I:C without additional cytokines or contact to other types of immune cells. Poly I-C 235-243 interleukin 6 Homo sapiens 169-173 20040350-16 2010 KDQOL-CF correlated inversely with levels of IL-6, TNF-alpha and IL-10. kdqol 0-5 interleukin 6 Homo sapiens 45-49 19786147-5 2010 We then assessed the role of stigmasterol on the expression of various genes involved in inflammation (IL-6) and cartilage turn-over (MMP-3, -13, ADAMTS-4, -5, type II collagen, aggrecan) by quantitative Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR). Stigmasterol 29-41 interleukin 6 Homo sapiens 103-107 19931737-8 2009 The p38 inhibitor SB203580, by blocking nuclear factor-kappaB (NF-kappaB) activation, prevented both the transcriptional and translational regulation of radiation-induced IL-6 expression. SB 203580 18-26 interleukin 6 Homo sapiens 171-175 19908944-0 2009 The cannabinoid R+ methanandamide induces IL-6 secretion by prostate cancer PC3 cells. methanandamide 19-33 interleukin 6 Homo sapiens 42-46 19745053-3 2009 5-aza-2"-deoxycytidine (DAC), but not trichostatin A (TSA), activates the expression of IL-6 in all cell lines, indicating that DNA methylation, but not histone deacetylation, plays an essential role in IL-6 silencing. Decitabine 0-22 interleukin 6 Homo sapiens 88-92 19745053-3 2009 5-aza-2"-deoxycytidine (DAC), but not trichostatin A (TSA), activates the expression of IL-6 in all cell lines, indicating that DNA methylation, but not histone deacetylation, plays an essential role in IL-6 silencing. Decitabine 0-22 interleukin 6 Homo sapiens 203-207 19715447-5 2009 RESULTS/CONCLUSIONS: Tocilizumab, which blocks IL-6 binding to IL-6 receptor, used as monotherapy or in combination with methotrexate for RA therapy leads to significant clinical response and amelioration of joint damage, which is superior to methotrexate. Radium 138-140 interleukin 6 Homo sapiens 47-51 19715447-5 2009 RESULTS/CONCLUSIONS: Tocilizumab, which blocks IL-6 binding to IL-6 receptor, used as monotherapy or in combination with methotrexate for RA therapy leads to significant clinical response and amelioration of joint damage, which is superior to methotrexate. Radium 138-140 interleukin 6 Homo sapiens 63-67 19656660-12 2009 Distinctly, pharmacological inhibition of p38 MAPK with SB203580 was associated with transcriptional down-regulation of COX-2 and MMP-13 in the IL-1beta- or PMA-treated HSF cells. SB 203580 56-64 interleukin 6 Homo sapiens 169-172 19576293-10 2009 As intracellular signalling pathway we could demonstrate that SB203580 as specific p38 inhibitor most effectively down regulated the unwanted IL-6 release after cooling and rewarming. SB 203580 62-70 interleukin 6 Homo sapiens 142-146 19616541-6 2009 Treatment with either 5-ASA or taurine chloramine (TauCl) inhibited IL-1beta-mediated NFkappaB dependent luciferase expression and IL-6 secretion. N-chlorotaurine 31-49 interleukin 6 Homo sapiens 131-135 19616541-6 2009 Treatment with either 5-ASA or taurine chloramine (TauCl) inhibited IL-1beta-mediated NFkappaB dependent luciferase expression and IL-6 secretion. N-chlorotaurine 51-56 interleukin 6 Homo sapiens 131-135 19750100-7 2009 RESULTS: We found the most consistent modifications for variants in IL6 rs2069832 and FBG rs1800790 after exposure to carbon monoxide (CO; 24-hr average; p-values for interaction, 0.034 and 0.019, respectively). Carbon Monoxide 118-133 interleukin 6 Homo sapiens 68-71 19750100-7 2009 RESULTS: We found the most consistent modifications for variants in IL6 rs2069832 and FBG rs1800790 after exposure to carbon monoxide (CO; 24-hr average; p-values for interaction, 0.034 and 0.019, respectively). Carbon Monoxide 135-137 interleukin 6 Homo sapiens 68-71 18824341-9 2009 Lycopene also decreased the release of IL-6 and IP-10 following exposure to lipopolysaccharide. Lycopene 0-8 interleukin 6 Homo sapiens 39-43 19522763-3 2009 We have shown that all these cell lines express TLR3 on mRNA and protein level but it is only functional in Detroit 562 cell line since only in these cells poly I:C treatment triggered the IL-6 secretion. Poly I-C 156-164 interleukin 6 Homo sapiens 189-193 19279008-2 2009 Here, we examine the role of the GBA1-ceramide pathway, in regulating a pro-inflammatory pathway initiated by PKC and leading to activation of p38 and induction of interleukin 6 (IL-6). Ceramides 38-46 interleukin 6 Homo sapiens 164-177 19279008-2 2009 Here, we examine the role of the GBA1-ceramide pathway, in regulating a pro-inflammatory pathway initiated by PKC and leading to activation of p38 and induction of interleukin 6 (IL-6). Ceramides 38-46 interleukin 6 Homo sapiens 179-183 19452017-10 2009 The poly(I:C)-induced expressions of IL-6 and IL-8 were down-regulated by both DEX and CsA, while the expressions of IFN-beta and TLR3 were suppressed by DEX alone. Poly I-C 4-12 interleukin 6 Homo sapiens 37-41 19513781-8 2009 An increase in IL-6 secretion was also observed in cells stimulated with Alternaria extract after pretreatment with Poly IC. Poly I-C 116-123 interleukin 6 Homo sapiens 15-19 19434815-6 2009 CONCLUSIONS: Treatment with levamisole and colchicine can result in a significant reduction of serum IL-6, IL-8 or TNF-alpha level in MCBD patients. Levamisole 28-38 interleukin 6 Homo sapiens 101-105 19085934-9 2009 Exogenous L-DOPA inhibited lymphocyte proliferation producing the cell cycle arrest in G1/0 and dramatically inhibited the production of IL-1beta, TNF-alpha, IL-6 and IL-10. Levodopa 10-16 interleukin 6 Homo sapiens 158-162 19285012-7 2009 IL-6-dependent dimerization of STAT3, c-myc promoter binding and c-myc protein expression were all suppressed by 5,15-DPP, whereas no decrement in either expression or phosphorylation level of STAT3 was observed. 5,15-diphenylporphyrin 113-121 interleukin 6 Homo sapiens 0-4 18820825-2 2009 The purpose of our study was to investigate the effect of pioglitazone on systemic inflammatory markers and activation of circulating monocytes in type 2 diabetic patients through the dosage of IL-6. Pioglitazone 58-70 interleukin 6 Homo sapiens 194-198 18820825-5 2009 IL-6 production of circulating monocytes after LPS stimulation was similar at baseline and showed a 54% reduction in pioglitazone-group at 8 weeks (9.1 pg/mL, range 0.0-24.3, P=0.04 vs. baseline) while, in controls, did not change at 8 weeks (16.9 pg/mL, range 1.5-58.8). Pioglitazone 117-129 interleukin 6 Homo sapiens 0-4 18820825-6 2009 Treatment with pioglitazone, associated with metformin, showed a reduction of IL-6 monocyte production after their in vitro activation with LPS. Pioglitazone 15-27 interleukin 6 Homo sapiens 78-82 19218094-7 2009 Sulodexide caused the inhibition of the intracellular generation of free radicals in a dose-dependent manner (maximally by 32%, P < 0.01), as well as the inhibition of MCP-1 (maximally by 60%, P < 0.001) and IL-6 (maximally by 69%, P < 0.01). glucuronyl glucosamine glycan sulfate 0-10 interleukin 6 Homo sapiens 214-218 19061939-0 2009 Neuroprotection of interleukin-6 against NMDA attack and its signal transduction by JAK and MAPK. N-Methylaspartate 41-45 interleukin 6 Homo sapiens 19-32 19017034-6 2009 IL-6(-174) genotype and 3-year GHbA1c associated significantly with BOP and PD>or=4 mm, subjects with the GG genotype of the IL-6(-174) exhibiting more severe periodontal disease than those with the GC/CC genotype. bop 68-71 interleukin 6 Homo sapiens 0-4 18945671-6 2008 The ability of eNampt to trigger this IL-6/STAT3 cell survival pathway did not depend on the presence of the Nampt enzymatic substrate nicotinamide in the medium, could not be mimicked by the Nampt enzymatic product nicotinamide mononucleotide (NMN), was not blocked by the Nampt enzyme inhibitor FK866, and showed no correlation with enzyme activity in a series of site-directed mutant Nampt proteins. Niacinamide 135-147 interleukin 6 Homo sapiens 38-42 18945671-6 2008 The ability of eNampt to trigger this IL-6/STAT3 cell survival pathway did not depend on the presence of the Nampt enzymatic substrate nicotinamide in the medium, could not be mimicked by the Nampt enzymatic product nicotinamide mononucleotide (NMN), was not blocked by the Nampt enzyme inhibitor FK866, and showed no correlation with enzyme activity in a series of site-directed mutant Nampt proteins. Nicotinamide Mononucleotide 245-248 interleukin 6 Homo sapiens 38-42 19278477-9 2008 Aqueous levels of IL-6 normalized in all patients 3 months after IVTA. ivta 65-69 interleukin 6 Homo sapiens 18-22 19278477-11 2008 CONCLUSIONS: IL-6-independent VEGF secretion may contribute to persistent macular oedema associated with ischaemic BRVO after IVTA. ivta 126-130 interleukin 6 Homo sapiens 13-17 18368033-4 2008 Glucocorticoid function was measured by glucocorticoid inhibition of lypopolysaccharide (LPS)-stimulated interleukin-6 (IL-6) levels. lps 89-92 interleukin 6 Homo sapiens 105-118 18368033-4 2008 Glucocorticoid function was measured by glucocorticoid inhibition of lypopolysaccharide (LPS)-stimulated interleukin-6 (IL-6) levels. lps 89-92 interleukin 6 Homo sapiens 120-124 18368033-5 2008 The results show that glucocorticoids (dexamethasone, prednisolone, cortisol and corticosterone) caused a concentration-dependent inhibition of LPS-stimulated IL-6 levels. Prednisolone 54-66 interleukin 6 Homo sapiens 159-163 18368033-5 2008 The results show that glucocorticoids (dexamethasone, prednisolone, cortisol and corticosterone) caused a concentration-dependent inhibition of LPS-stimulated IL-6 levels. lps 144-147 interleukin 6 Homo sapiens 159-163 18368033-6 2008 In healthy controls, CMI decreased glucocorticoid inhibition of LPS-stimulated IL-6 levels, while this effect was not present in depressed patients. lps 64-67 interleukin 6 Homo sapiens 79-83 18787007-5 2008 Infection of human peripheral blood mononuclear cell-derived immature DC with SV5-flagellin resulted in enhanced levels of interleukin-6 (IL-6) and IL-12 compared to infection with DC with the parental virus, WT SV5. sv5-flagellin 78-91 interleukin 6 Homo sapiens 123-136 18787007-5 2008 Infection of human peripheral blood mononuclear cell-derived immature DC with SV5-flagellin resulted in enhanced levels of interleukin-6 (IL-6) and IL-12 compared to infection with DC with the parental virus, WT SV5. sv5-flagellin 78-91 interleukin 6 Homo sapiens 138-142 18407307-7 2008 Arsenic exposure reduced the proliferative response of SMC to Con-A, and also reduced secretion of IL-2, IL-6, IL-12 and IFNgamma. Arsenic 0-7 interleukin 6 Homo sapiens 105-109 18457971-5 2008 p38 MAPK inhibitor SB203580 suppressed interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) release, as well as the activation of cPLA(2). SB 203580 19-27 interleukin 6 Homo sapiens 72-85 18457971-5 2008 p38 MAPK inhibitor SB203580 suppressed interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) release, as well as the activation of cPLA(2). SB 203580 19-27 interleukin 6 Homo sapiens 87-91 18457971-8 2008 As a downstream enzyme of cPLA(2), cyclooxygenase-2 (COX-2) was down-regulated by SB203580 and/or AACOCF(3), which precisely matched the levels of IL-1beta and IL-6. SB 203580 82-90 interleukin 6 Homo sapiens 160-164 18522857-7 2008 Moreover the butyrate-treated immature DCs showed lower production of IL-12 p40 and IL-6 in response to lipopolysaccharides and induced less Th1 cells in allogenic mixed lymphocyte reactions. Butyrates 13-21 interleukin 6 Homo sapiens 84-88 17611043-2 2008 In this study, the in vitro effects of a new aziridine, 2-hydroxy-methyl-1-(N-phtaloyltryptophyl) aziridine, were determined on the proliferative responses of human lymphocytes stimulated by mitogens and on interleukin (IL-2, IL-6) secretion. aziridine 45-54 interleukin 6 Homo sapiens 226-230 18299313-8 2008 Proinflammatory IL-6 was elevated in patients with good metabolic control after 1 month (P = 0.009) and showed a positive association with blood glucose disposal after 12 months (P = 0.047). Blood Glucose 139-152 interleukin 6 Homo sapiens 16-20 18292576-8 2008 SB203580 inhibited the phosphorylation of c-Fos enhanced by IL-1 plus IL-6, and diminished expression of the CRP gene. SB 203580 0-8 interleukin 6 Homo sapiens 70-74 17845838-4 2008 We found that pre-treatment of microglial cells with a p38-inhibitor (SB203580) prevented Mn+LPS-induced production of IL-6 and TNF-alpha. SB 203580 70-78 interleukin 6 Homo sapiens 119-123 19012528-1 2008 BACKGROUND: Biogenic amine, adrenaline, noradrenaline, dopamine and 5-hydroxy-tryptamine (5-HT) levels are related to interleukin-6 (IL-6) plasma concentrations and endurance exercise. Epinephrine 28-38 interleukin 6 Homo sapiens 118-131 19012528-1 2008 BACKGROUND: Biogenic amine, adrenaline, noradrenaline, dopamine and 5-hydroxy-tryptamine (5-HT) levels are related to interleukin-6 (IL-6) plasma concentrations and endurance exercise. Epinephrine 28-38 interleukin 6 Homo sapiens 133-137 18306624-8 2007 The increasing trend of IL-6 and IL-10 levels were similar in both groups, whereas the level of IL-6 at T1 in propofol group was lower than that of isoflurane group significantly (P < 0.01), however the level of IL-10 was much higher in propofol group than that of isoflurane group at T1 and T2 (P < 0.05). Propofol 110-118 interleukin 6 Homo sapiens 96-100 17581928-3 2007 IL-6 increased the level of alpha-methyl-d-[(14)C]glucopyranoside (alpha-MG) uptake in time- and dose-dependent manners. alpha-methyl-d-[(14)c]glucopyranoside 28-65 interleukin 6 Homo sapiens 0-4 17581928-7 2007 On the other hand, IL-6 increased the level of 5-(and-6)-chloromethyl-2",7"-dichlorodihydrofluorescein diacetate-sensitive cellular reactive oxygen species (ROS), and IL-6-induced increases in alpha-MG uptake and the protein expression level of SGLTs were blocked by ascorbic acid or taurine (antioxidants). Taurine 284-291 interleukin 6 Homo sapiens 19-23 17957548-8 2007 Both HP and LP CAPs stimulated the release of proinflammatory cytokines tumor necrosis factor (TNF) alpha and interleukin (IL)-6 after 6 h of exposures. Hematoporphyrins 5-7 interleukin 6 Homo sapiens 110-128 17470570-7 2007 L-NAME caused marked reductions in exercise-induced expression of 4 of 11 mRNAs including IL-6, IL-8, and HO-1. NG-Nitroarginine Methyl Ester 0-6 interleukin 6 Homo sapiens 90-94 17335558-7 2007 In the case of human peripheral blood mononuclear cells, compound PG-381-5FA showed much stronger IL-6-inducing activity than compound PG-381-3FA. pg-381-5fa 66-76 interleukin 6 Homo sapiens 98-102 17593869-4 2007 The IL-6/IL-10 ratio significantly increased with propofol compared with isoflurane on day 1 after surgery and the IL-10 level significantly increased with isoflurane on day 1 after surgery. Propofol 50-58 interleukin 6 Homo sapiens 4-8 17390058-0 2007 Pitavastatin inactivates NF-kappaB and decreases IL-6 production through Rho kinase pathway in MCF-7 cells. pitavastatin 0-12 interleukin 6 Homo sapiens 49-53 17390058-6 2007 Finally, the addition of TNF-alpha significantly increased IL-6 protein production, which was suppressed by the addition of pitavastatin. pitavastatin 124-136 interleukin 6 Homo sapiens 59-63 17390058-7 2007 These results suggest that pitavastatin at low dose (1 microM) inhibits NF-kappaB activation and decreases IL-6 production induced by TNF-alpha. pitavastatin 27-39 interleukin 6 Homo sapiens 107-111 17437036-0 2007 Interleukin-6 protects cerebellar granule neurons from NMDA-induced neurotoxicity. N-Methylaspartate 55-59 interleukin 6 Homo sapiens 0-13 17437036-2 2007 However, the neuroprotection of IL-6 against N-methyl-D-aspartate (NMDA)-induced neurotoxicity and the related underlying mechanisms are still not identified. N-Methylaspartate 45-65 interleukin 6 Homo sapiens 32-36 17437036-2 2007 However, the neuroprotection of IL-6 against N-methyl-D-aspartate (NMDA)-induced neurotoxicity and the related underlying mechanisms are still not identified. N-Methylaspartate 67-71 interleukin 6 Homo sapiens 32-36 17437036-8 2007 The NMDA stimulation of the CGNs chronically pretreated with IL-6 caused a remarkable increase in the neuronal vitality, marked suppression of neuronal apoptosis and intracellular Ca(2+) overload in the neurons, compared with that in the control neurons without IL-6 pretreatment. N-Methylaspartate 4-8 interleukin 6 Homo sapiens 61-65 17437036-8 2007 The NMDA stimulation of the CGNs chronically pretreated with IL-6 caused a remarkable increase in the neuronal vitality, marked suppression of neuronal apoptosis and intracellular Ca(2+) overload in the neurons, compared with that in the control neurons without IL-6 pretreatment. N-Methylaspartate 4-8 interleukin 6 Homo sapiens 262-266 17437036-9 2007 Furthermore, anti-gp130 antibody blocked the inhibitory effect of IL-6 on NMDA-induced intracellular Ca(2+) overload in the neurons. N-Methylaspartate 74-78 interleukin 6 Homo sapiens 66-70 17437036-11 2007 The results suggest that chronic IL-6 pretreatment of CGNs protects the neurons against NMDA-induced neurotoxicity. N-Methylaspartate 88-92 interleukin 6 Homo sapiens 33-37 17437036-12 2007 The neuroprotective effect of IL-6 is closely related to its suppression of NMDA-induced intracellular Ca(2+) overload and is possibly mediated by gp130/JAK-STAT3 and gp130/RAS-ERK1/2 transduction pathways. N-Methylaspartate 76-80 interleukin 6 Homo sapiens 30-34 17339835-1 2007 In this issue of British Journal of Pharmacology, Megias and colleagues demonstrate how preincubation of human colonic Caco-2 cells with CORM-2, a carbon monoxide releasing molecule (CO-RM), reduces the expression of inducible nitric oxide synthase, interleukin (IL)-6 and IL-8 caused by proinflammatory cytokines. Carbon Monoxide 147-162 interleukin 6 Homo sapiens 250-268 17022108-7 2007 At multiple regression analysis, IL-6 was associated with BI in the whole sample and in VD, but not in LOAD, independent of age, gender, smoking, alcohol consumption, hypertension, diabetes, coronary heart disease, previous stroke, and mini mental state examination score. Bismuth 58-60 interleukin 6 Homo sapiens 33-37 17374166-4 2007 Polyphenolic compounds found in plants, fruits and vegetables inhibit Interleukin 6 mediated inflammation by direct inhibition of the signal transduction pathway. polyphenolic compounds 0-22 interleukin 6 Homo sapiens 70-83 16946718-4 2007 The P2 antagonists, suramin-, reactive blue 2-, and periodate-oxidized ATP, inhibited ATP-induced IL-6 release, whereas pyridoxal-phosphate-6-azophenyl-2",4"-disulfonic acid, adenosine 3"-phosphate 5"-phosphate, 1-[N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, and pertussis toxin did not. Cibacron Blue F 3GA 30-45 interleukin 6 Homo sapiens 98-102 16868648-5 2007 When applied at noncytotoxic concentrations: (i) Tau-Br inhibited IL-6 and PGE2 production with potency similar to Tau-Cl (IC50 approximately 250 microM), (ii) Tau-Br failed to affect VEGF and IL-8 synthesis, while Tau-Cl exerted inhibitory effect (IC50 approximately 400 microM), (iii) none of these compounds affected NO generation and iNOS expression. N-bromotaurine 49-55 interleukin 6 Homo sapiens 66-70 17197193-11 2006 AG490, SB203580, piceatannol, parthenolide and cycloheximide inhibit CT-1 induced IL-6 mRNA and protein expression whereas wortmannin and PD98059 did not inhibit IL-6 expression. SB 203580 7-15 interleukin 6 Homo sapiens 82-86 17063122-6 2006 After activation with polyinosinic-polycytidylic acid, BDCs expressed higher levels of major histocompatibility complex class I, CD40, CD80, and CD83, and secreted higher levels of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, and IL-8 compared with MoDCs. Poly I-C 22-53 interleukin 6 Homo sapiens 234-238 16977386-5 2006 On the contrary, Hyiodine inhibited the PMA-activated oxidative burst and significantly increased the production of IL-6 and TNF-alpha by lymphocytes. hyaluronan-iodine complex 17-25 interleukin 6 Homo sapiens 116-120 16716147-9 2006 The purified mini-gp130-ELP specifically inhibited sIL-6R-mediated trans-signalling as measured by binding to the IL-6-sIL-6R complex and through its ability to block sIL-6R-mediated activation of STAT3 (signal transducer and activator of transcription 3) phosphorylation and proliferation in human hepatoma cells and murine pre-B-cells. sil-6r 119-125 interleukin 6 Homo sapiens 52-56 16966508-6 2006 RESULTS: Serum samples positive for NAbs significantly inhibited polyinosinic-polycytidylic acid-induced CXCL10 and IL-6 production by astrocytes. Poly I-C 65-96 interleukin 6 Homo sapiens 116-120 16600214-3 2006 In this report, we demonstrate that the p38alpha MAPK inhibitor, SCIO-469, suppresses secretion of the tumor-supportive factors IL-6 and VEGF from BM stromal cells (BMSCs) as well as cocultures of BMSCs with MM cells, resulting in reduction in MM cell proliferation. SCIO-469 65-73 interleukin 6 Homo sapiens 128-132 16413037-0 2006 15-Deoxy-Delta(12,14)-prostaglandin J(2) suppresses IL-6-induced STAT3 phosphorylation via electrophilic reactivity in endothelial cells. 15-deoxy-delta(12,14)-prostaglandin j 0-37 interleukin 6 Homo sapiens 52-56 16381797-5 2006 Inhibitors of IP(3)-dependent Ca(2+) signals, like 2-aminoethoxydiphenyl borate (2-APB) and U-73122, decreased activation of IL-6 gene expression as did Ca(2+) signals inhibitor BAPTA-AM, whereas ryanodine, a fast Ca(2+) transient inhibitor, had no effect on IL-6 induction. 2-aminoethoxydiphenyl borate 51-79 interleukin 6 Homo sapiens 125-129 16381797-5 2006 Inhibitors of IP(3)-dependent Ca(2+) signals, like 2-aminoethoxydiphenyl borate (2-APB) and U-73122, decreased activation of IL-6 gene expression as did Ca(2+) signals inhibitor BAPTA-AM, whereas ryanodine, a fast Ca(2+) transient inhibitor, had no effect on IL-6 induction. 2-aminoethoxydiphenyl borate 51-79 interleukin 6 Homo sapiens 259-263 16159895-7 2006 Pioglitazone therapy in men with advanced diabetic nephropathy reduced WBC count by 1,125/mul (P < 0.001), CRP by 41% (P = 0.042), IL-6 by 38% (P = 0.009), and MMP-9 by 29% (P = 0.016). Pioglitazone 0-12 interleukin 6 Homo sapiens 134-138 16159895-8 2006 Specific differential reductions in WBC count of 1,251/mul (P = 0.009) and reduction in IL-6 of 58% with pioglitazone (P = 0.001) were seen compared with glipizide. Pioglitazone 105-117 interleukin 6 Homo sapiens 88-92 17153635-6 2006 Both TRD and TRD-Cl, more effectively than TauCl, inhibited the production of IL-6 by stimulated macrophages. trd-cl 13-19 interleukin 6 Homo sapiens 78-82 16388744-6 2006 Effect of decoy ODNs on the growth of 8266 cells stimulated with IL-6 was measured by MTT Colorimetry assay. monooxyethylene trimethylolpropane tristearate 86-89 interleukin 6 Homo sapiens 65-69 16447674-5 2005 The data demonstrate that LHXT has the actions of reducing serum levels of TNF-alpha, IFN-gamma and IL-6 in psoriasis of blood-heat type, and may exert a pharmacological effect targeting at the cytokines. lhxt 26-30 interleukin 6 Homo sapiens 100-104 15580352-0 2005 The advanced glycation end product pentosidine correlates to IL-6 and other relevant inflammatory markers in rheumatoid arthritis. pentosidine 35-46 interleukin 6 Homo sapiens 61-65 15580352-6 2005 RESULTS: Serum levels of pentosidine were on average significantly higher in RA patients than in healthy subjects and correlated significantly to ESR, CRP, and serum levels of IL-6. pentosidine 25-36 interleukin 6 Homo sapiens 176-180 16243974-4 2005 We demonstrate that CpdA exerts an antiinflammatory potential by down-modulating TNF-induced proinflammatory gene expression, such as IL-6 and E-selectin, but, interestingly, does not at all enhance glucocorticoid response element-driven genes or induce GR binding to glucocorticoid response element-dependent genes in vivo. CPDA 20-24 interleukin 6 Homo sapiens 134-138 15963685-6 2005 A whole blood method was used to determine lipopolysaccharide-(LPS) and peptidoglycan-(PGN) stimulated IL-6, IL-1beta, and TNF-alpha production with supernatants analyzed using ELISA. pgn 87-90 interleukin 6 Homo sapiens 103-107 15913932-5 2005 Increased IL-6 by DFX was significantly inhibited by p38 inhibitor, SB203580 (about 72% inhibition, P=0.027) but not ERK inhibitor, PD98059 or JNK inhibitor, SP600125. SB 203580 68-76 interleukin 6 Homo sapiens 10-14 16312193-8 2005 Interleukin-6 production was significantly higher for stainless steel than for titanium and the alloy. Stainless Steel 54-69 interleukin 6 Homo sapiens 0-13 16079075-11 2005 Among the elements in the first factor, Fe and Si correlated with IL-6 release, whereas Cr correlated with IL-8 release. Silicon 47-49 interleukin 6 Homo sapiens 66-70 16046706-8 2005 However, the phosphoinositide-3 kinase (PI3K) inhibitor, wortmannin, alone and additively with palmitate, activated the NF-kappaB reporter gene and induced IL-6 expression (P < 0.05). Wortmannin 57-67 interleukin 6 Homo sapiens 156-160 15992579-10 2005 In real-time PCR studies, the mRNA for interleukin-6 (IL-6) was found to be increased by 2.5-fold in MC-3 cells after 1 h incubation with 5-CT (1 microM) and this effect was fully blocked by the 5-HT7 receptor antagonist SB-269970 (1 microM). 5-carboxamidotryptamine 138-142 interleukin 6 Homo sapiens 39-52 15992579-10 2005 In real-time PCR studies, the mRNA for interleukin-6 (IL-6) was found to be increased by 2.5-fold in MC-3 cells after 1 h incubation with 5-CT (1 microM) and this effect was fully blocked by the 5-HT7 receptor antagonist SB-269970 (1 microM). 5-carboxamidotryptamine 138-142 interleukin 6 Homo sapiens 54-58 15992579-10 2005 In real-time PCR studies, the mRNA for interleukin-6 (IL-6) was found to be increased by 2.5-fold in MC-3 cells after 1 h incubation with 5-CT (1 microM) and this effect was fully blocked by the 5-HT7 receptor antagonist SB-269970 (1 microM). SB 269970 221-230 interleukin 6 Homo sapiens 39-52 15992579-10 2005 In real-time PCR studies, the mRNA for interleukin-6 (IL-6) was found to be increased by 2.5-fold in MC-3 cells after 1 h incubation with 5-CT (1 microM) and this effect was fully blocked by the 5-HT7 receptor antagonist SB-269970 (1 microM). SB 269970 221-230 interleukin 6 Homo sapiens 54-58 15845391-4 2005 Stimulation with polyI:C elicited the elevated production and mRNA expression of IL-6 and IL-8 in HCEC. Poly I-C 17-24 interleukin 6 Homo sapiens 81-85 15836614-8 2005 5-HT-induced IL-6 synthesis is inhibited by the partially selective 5-HT7 receptor antagonist, pimozide, and the selective antagonist SB269970. SB 269970 134-142 interleukin 6 Homo sapiens 13-17 16036801-6 2005 IL-6 levels returned to baseline following treatment of the patient with intravenous cyclophosphamide and plasma exchange and the patient experienced a significant and sustained recovery of function. Cyclophosphamide 85-101 interleukin 6 Homo sapiens 0-4 16277693-4 2005 The aim of this study was to determine if daily supplementation with 50 mg of pyridoxine for 30 days can correct the static and/or the functional abnormalities of vitamin B6 status seen in patients with rheumatoid arthritis, and further investigate if pyridoxine supplementation has any effects on the pro-inflammatory cytokine TNF-alpha or IL-6 production of arthritis. Pyridoxine 78-88 interleukin 6 Homo sapiens 341-345 16435581-2 2005 When added to HGFs, IL-1beta had a stimulatory effect on the production of IL-6, and this effect was significantly reduced by SB203580, a specific p38 MAPK inhibitor. SB 203580 126-134 interleukin 6 Homo sapiens 75-79 16435581-4 2005 Both the NF-kappaB inhibitors in the presence of SB203580 had more inhibitory effect on IL-6 release. SB 203580 49-57 interleukin 6 Homo sapiens 88-92 15284182-0 2004 IL-6-induced survival of colorectal carcinoma cells is inhibited by butyrate through down-regulation of the IL-6 receptor. Butyrates 68-76 interleukin 6 Homo sapiens 0-4 15284182-0 2004 IL-6-induced survival of colorectal carcinoma cells is inhibited by butyrate through down-regulation of the IL-6 receptor. Butyrates 68-76 interleukin 6 Homo sapiens 108-112 15284182-6 2004 Given the potential importance of IL-6 in the pathogenesis of colorectal tumors, we tested the hypothesis that butyrate acts by inhibiting IL-6-induced signaling events in colorectal carcinoma cells. Butyrates 111-119 interleukin 6 Homo sapiens 34-38 15284182-6 2004 Given the potential importance of IL-6 in the pathogenesis of colorectal tumors, we tested the hypothesis that butyrate acts by inhibiting IL-6-induced signaling events in colorectal carcinoma cells. Butyrates 111-119 interleukin 6 Homo sapiens 139-143 15284182-7 2004 Following treatment with butyrate, the activation of STAT1 in response to IL-6, but not interferon-gamma, was completely lost. Butyrates 25-33 interleukin 6 Homo sapiens 74-78 15284182-8 2004 Butyrate induced a prominent decrease of mRNA and cell surface expression of the IL-6 receptor alpha (IL-6Ralpha) chain. Butyrates 0-8 interleukin 6 Homo sapiens 81-85 15284182-9 2004 Introduction of a soluble form of the IL-6Ralpha chain restored IL-6-induced STAT1 activation and resistance to apoptosis of butyrate treated cells. Butyrates 125-133 interleukin 6 Homo sapiens 38-42 15284182-10 2004 These experiments indicate that IL-6 may play an important role in the pathogenesis of colorectal cancers, and that butyrate may exert its protective effect by specifically blocking IL-6-induced signaling events. Butyrates 116-124 interleukin 6 Homo sapiens 182-186 15210834-3 2004 The PAR-1 agonist peptide SFLLRN mimicked the thrombin-induced IL-6 production in the presence of amastatin, an aminopeptidase inhibitor. amastatin 98-107 interleukin 6 Homo sapiens 63-67 15180973-0 2004 Epinephrine infusion increases adipose interleukin-6 gene expression and systemic levels in humans. Epinephrine 0-11 interleukin 6 Homo sapiens 39-52 15180973-2 2004 We, therefore, explored the possible role of epinephrine in the induction of IL-6 in adipose tissue. Epinephrine 45-56 interleukin 6 Homo sapiens 77-81 15180973-5 2004 The level of IL-6 mRNA in subcutaneous adipose tissue increased 26-fold (95% confidence interval, 9- to 166-fold) at 3 h of epinephrine infusion compared with controls (P=0.028). Epinephrine 124-135 interleukin 6 Homo sapiens 13-17 15180973-6 2004 In addition, plasma levels of IL-6 increased in response to epinephrine infusion (P <0.001). Epinephrine 60-71 interleukin 6 Homo sapiens 30-34 15265658-10 2004 Poly I:C treatment of RPE resulted in an increase in the production of IL-6, IL-8, MCP-1, and sICAM-1. Poly I-C 0-8 interleukin 6 Homo sapiens 71-75 15131005-10 2004 Ramipril and valsartan markedly decreased the expression levels of TNF-alpha, IL-6, and iNOS, and, to a lesser extent, of IFN-gamma genes, but did not affect the number of DR+ cells, with no significant difference between the 2 treatments. Ramipril 0-8 interleukin 6 Homo sapiens 78-82 15131005-10 2004 Ramipril and valsartan markedly decreased the expression levels of TNF-alpha, IL-6, and iNOS, and, to a lesser extent, of IFN-gamma genes, but did not affect the number of DR+ cells, with no significant difference between the 2 treatments. Valsartan 13-22 interleukin 6 Homo sapiens 78-82 15163543-10 2004 Recent studies have shown that, in subjects with chronic arsenic exposure, oxidative stress is increased and the expression of tumor necrosis factor alpha (TNFalpha) and interleukin-6 (IL-6) is upregulated. Arsenic 57-64 interleukin 6 Homo sapiens 170-183 15163543-10 2004 Recent studies have shown that, in subjects with chronic arsenic exposure, oxidative stress is increased and the expression of tumor necrosis factor alpha (TNFalpha) and interleukin-6 (IL-6) is upregulated. Arsenic 57-64 interleukin 6 Homo sapiens 185-189 14991615-7 2004 Furthermore, we showed that caps-PS induce production of IL-4, IL-6, IL-10, and IFN-gamma, and that this enhanced production was inhibited by blocking the CD40-CD40L interaction. caps-ps 28-35 interleukin 6 Homo sapiens 63-67 14563701-6 2004 Isolation of Triton X-100-insoluble raft fractions from LNCaP cells by discontinuous sucrose gradient centrifugation demonstrated that the 80-kDa IL-6 receptor localized almost exclusively to the raft compartment. Sucrose 85-92 interleukin 6 Homo sapiens 146-150 14644389-8 2003 Pioglitazone also inhibited the induction of EN-RAGE mRNA by IL-6. Pioglitazone 0-12 interleukin 6 Homo sapiens 61-65 14676117-10 2003 Correlative studies demonstrated a progressive increase in serum interleukin-6 with bryostatin 1 infusion followed by an additional increase after vincristine. bryostatin 1 84-96 interleukin 6 Homo sapiens 65-78 14625484-5 2003 Animals, receiving epinephrine therapy, showed a significantly prolonged upregulation of IL-6 mRNA expression at 4 h after LPS application in liver (P = 0.0014), spleen (P < 0.0001), and mesenteric lymph nodes (P = 0.0078) as compared with animals treated with norepinephrine or fluid resuscitation. Epinephrine 19-30 interleukin 6 Homo sapiens 89-93 14625484-10 2003 Our data suggest that the therapeutic application of epinephrine but not of norepinephrine is associated with a profound effect on the IL-6 response of splanchnic reticuloendothelial tissues. Epinephrine 53-64 interleukin 6 Homo sapiens 135-139 14562010-13 2003 Assessment of biological activity of bryostatin-1 was carried out using the whole-blood cytokine release assay in six patients, two of whom had a rise in IL-6 levels 24 h after initiating bryostatin-1 therapy compared to pretreatment values. bryostatin 1 37-49 interleukin 6 Homo sapiens 154-158 12714376-9 2003 Inhibition of extracellular signal-regulated kinase had no effect in normal-Fb, but reversed the antiapoptotic effect of IL-6 in IPF-Fb. ipf-fb 129-135 interleukin 6 Homo sapiens 121-125 12900383-1 2003 Previously, we demonstrated that epinephrine induced the expression of interleukin (IL)-6 mRNA via beta-adrenoceptors in cultured human osteoblastic cells. Epinephrine 33-44 interleukin 6 Homo sapiens 71-89 12845688-5 2003 The combination of pamidronate with VAD-chemotherapy produced a reduction in TRACP-5b, NTX, IL-6, paraprotein and beta2-microglobulin levels from the 2nd month of treatment, with no effect on bone formation and OPG. VAD I protocol 36-39 interleukin 6 Homo sapiens 92-96 12951277-5 2003 There was a strong positive correlation between the vitreous levels of pentosidine and IL-6. pentosidine 71-82 interleukin 6 Homo sapiens 87-91 12859689-3 2003 CT-1, but not IL-6 or TNFalpha, suppressed NE uptake and catecholamines in these neurons, whereas CT-1 and, to a lesser extent, IL-6 decreased BH4 content. sapropterin 143-146 interleukin 6 Homo sapiens 128-132 12637577-2 2003 Here we show unequivocally that the production of interleukin (IL)-1beta, IL-6, IL-10, and tumor necrosis factor alpha (TNFalpha) requires p38 MAPK activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha (SBR-p38alpha) that fails to bind to SB 203580. SB 203580 205-214 interleukin 6 Homo sapiens 74-78 12801316-10 2003 Moreover, 10-5 M pranlukast and MK-571 inhibited LPS-induced IL-6 production in PBMC by about 65% and 15%, respectively. pranlukast 17-27 interleukin 6 Homo sapiens 61-65 12595750-0 2003 Effect of interleukin 6 on the hepatic metabolism of itraconazole and its metabolite hydroxyitraconazole using primary human hepatocytes. Itraconazole 53-65 interleukin 6 Homo sapiens 10-23 12626585-7 2003 In contrast to the IL-6 signal transducer gp130, which has been previously shown to recruit SOCS3 to one of its phosphotyrosine residues (Y759), peptide precipitation experiments suggest that SOCS3 does not interact with phosphorylated tyrosine motifs of the IL-10R. Phosphotyrosine 112-127 interleukin 6 Homo sapiens 19-23 12729481-2 2003 The cause of this dysfunction is not known, although proinflammatory cytokines such as interleukin-6 (IL-6) have been implicated in the inhibition of hepatic conversion of thyroxine (T(4)) to T(3). Thyroxine 172-181 interleukin 6 Homo sapiens 87-100 12729481-2 2003 The cause of this dysfunction is not known, although proinflammatory cytokines such as interleukin-6 (IL-6) have been implicated in the inhibition of hepatic conversion of thyroxine (T(4)) to T(3). Thyroxine 172-181 interleukin 6 Homo sapiens 102-106 12599093-2 2003 CSBG induced a slight increase in the spontaneous release of proinflammatory cytokines, such as interleukin (IL)-6, but significantly suppressed endotoxin-induced IL-6 production in cultures of PBMC and monocytes isolated from PBMC. csbg 0-4 interleukin 6 Homo sapiens 96-114 12599093-2 2003 CSBG induced a slight increase in the spontaneous release of proinflammatory cytokines, such as interleukin (IL)-6, but significantly suppressed endotoxin-induced IL-6 production in cultures of PBMC and monocytes isolated from PBMC. csbg 0-4 interleukin 6 Homo sapiens 163-167 12509497-8 2003 Thigh IL-6 release was also positively related to arterial plasma adrenaline concentration. Epinephrine 66-76 interleukin 6 Homo sapiens 6-10 12445202-7 2002 Use of the two phosphotidyl inositol 3-kinase inhibitors, LY294002 and wortmannin, to check whether this pathway is involved in Mcl-1 upregulation by interleukin-6, we found that the phosphotidyl inositol 3-kinase inhibitors completely attenuated the interleukin-6-induced Mcl-1 upregulation. Wortmannin 71-81 interleukin 6 Homo sapiens 150-163 12445202-7 2002 Use of the two phosphotidyl inositol 3-kinase inhibitors, LY294002 and wortmannin, to check whether this pathway is involved in Mcl-1 upregulation by interleukin-6, we found that the phosphotidyl inositol 3-kinase inhibitors completely attenuated the interleukin-6-induced Mcl-1 upregulation. Wortmannin 71-81 interleukin 6 Homo sapiens 251-264 12145290-7 2002 Finally, we show that interleukin-6 treatment in the presence or absence of overexpressed C/EBPbeta increased the promoter activities of reporter constructs containing nucleoside A at -217 compared with reporter constructs containing nucleoside G at -217. nucleoside a 168-180 interleukin 6 Homo sapiens 22-35 12215492-6 2002 On the other hand, PPAR-gamma ligands troglitazone, pioglitazone, and 15-deoxy-Delta(12,14)-prostaglandin J(2) inhibited IL-1beta-induced IL-6 expression at a transcriptional revel in VSMCs. Pioglitazone 52-64 interleukin 6 Homo sapiens 138-142 12353854-6 2002 IL-6 was higher in intestinal samples of the short-chain fatty acid group (P = 0.05), with the ileum having a greater abundance of IL-6 than the jejunum (P < 0.005). chain fatty acid 51-67 interleukin 6 Homo sapiens 0-4 12145097-7 2002 SB203580 decreased IL-6 production and gene expression, but PD98059 had no effect on IL-6 production and gene expression. SB 203580 0-8 interleukin 6 Homo sapiens 19-23 12165085-7 2002 T-HPMC and P-HPMC constitutively expressed IL-6 and IL-8 at both protein and mRNA level. t-hpmc 0-6 interleukin 6 Homo sapiens 43-47 12165085-11 2002 These data indicate that (1) T-HPMC lines mimic the morphological and functional features of P-HPMC, (2) P-HPMC and T-HPMC constituitively produce IL-6 and IL-8, which is enhanced by hIL-1beta and hTNF-alpha and (3) HPMC in vivo may participate in the pathogenesis of benign and malignant gynaecological disease. t-hpmc 29-35 interleukin 6 Homo sapiens 147-151 12165085-11 2002 These data indicate that (1) T-HPMC lines mimic the morphological and functional features of P-HPMC, (2) P-HPMC and T-HPMC constituitively produce IL-6 and IL-8, which is enhanced by hIL-1beta and hTNF-alpha and (3) HPMC in vivo may participate in the pathogenesis of benign and malignant gynaecological disease. t-hpmc 116-122 interleukin 6 Homo sapiens 147-151 12080442-9 2002 The effects of dexamethasone and catecholamines on IL-6 and leptin were abrogated by RU486 and propranolol, respectively. Propranolol 95-106 interleukin 6 Homo sapiens 51-55 12016129-9 2002 MAPK inhibitors (SB-203580, PD-98059, and U-0126) significantly reduced the IL-17-induced IL-6 and chemokine secretion. SB 203580 17-26 interleukin 6 Homo sapiens 90-94 12061506-5 2002 Recent data show that neuronal IL-6 expression is induced by excitatory amino acids or membrane depolarization. Excitatory Amino Acids 61-83 interleukin 6 Homo sapiens 31-35 11872747-7 2002 In contrast, IL-6-induced phosphorylation of 4E-BP1 was inhibited by rapamycin, wortmannin, and dominant negative AKT but ERK inhibitors had no effect, indicating ERK function was dispensable. Wortmannin 80-90 interleukin 6 Homo sapiens 13-17 12027404-6 2002 MTT cytotoxicity with IL-6 transfected cells demonstrates a five-fold increase in resistance to paclitaxel and a four-fold increase in resistance to doxorubicin as compared to U-2OS. monooxyethylene trimethylolpropane tristearate 0-3 interleukin 6 Homo sapiens 22-26 11846460-2 2002 We also demonstrated that Tau-Cl suppressed superoxide anion, IL-6, and IL-8 production in activated human polymorphonuclear leukocytes separated from peripheral blood. N-chlorotaurine 26-32 interleukin 6 Homo sapiens 62-66 11846460-6 2002 Production of IL-6, IL-8, and IL-2 in PHA-activated nonadherent leukocytes was inhibited by Tau-Cl. N-chlorotaurine 92-98 interleukin 6 Homo sapiens 14-18 12122578-12 2002 Although both CPZ and amiloride significantly reduced IL-6 release for all PM, the degree of inhibition was less for the PM-exposed DRG relative to BEAS-2B cells. Chlorpromazine 14-17 interleukin 6 Homo sapiens 54-58 12436208-1 2002 The effect of taurine (Tau) and taurine chloramine (Tau-Cl) on the production of TNF- alpha, IL-1 beta, and IL-6 by peripheral blood mononuclear cells of healthy volunteers was examined. Taurine 14-21 interleukin 6 Homo sapiens 108-112 12436208-1 2002 The effect of taurine (Tau) and taurine chloramine (Tau-Cl) on the production of TNF- alpha, IL-1 beta, and IL-6 by peripheral blood mononuclear cells of healthy volunteers was examined. Taurine 23-26 interleukin 6 Homo sapiens 108-112 12436208-1 2002 The effect of taurine (Tau) and taurine chloramine (Tau-Cl) on the production of TNF- alpha, IL-1 beta, and IL-6 by peripheral blood mononuclear cells of healthy volunteers was examined. N-chlorotaurine 32-50 interleukin 6 Homo sapiens 108-112 11747626-6 2001 In human osteoblasts (SaM-1 cells) treated with 10 microg/ml LPS, increases in IL-6 mRNA and synthesis were inhibited by anti-CD14 antibody (MEM-18), PD98059 (an inhibitor of classic mitogen-activated protein kinase [MAPK]), or SB203580 (an inhibitor of p38 MAPK) but were not inhibited by H-89 (an inhibitor of protein kinase A [PKA]) and calphostin C (an inhibitor of protein kinase C [PKC]). SB 203580 228-236 interleukin 6 Homo sapiens 79-83 11597988-8 2001 PD98059 and SB203580 inhibited Ang II-induced IL-6 expression. SB 203580 12-20 interleukin 6 Homo sapiens 46-50 11502577-7 2001 The increase in plasma IL-6 during epinephrine infusion was only sixfold, with the peak value at 1 h after infusion. Epinephrine 35-46 interleukin 6 Homo sapiens 23-27 11502577-12 2001 However, epinephrine induced a small increase in IL-6 and may, therefore, partly influence the plasma levels of IL-6 during exercise. Epinephrine 9-20 interleukin 6 Homo sapiens 49-53 11473728-0 2001 Enhancement of in vivo antitumor activity of a novel antimitotic 1-phenylpropenone derivative, AM-132, by tumor necrosis factor-alpha or interleukin-6. 3-oxo-3-phenylpropene 65-82 interleukin 6 Homo sapiens 137-150 11371414-9 2001 Moreover, using impairment of carbon monoxide transfer (DL(CO)) adjusted for duration of dyspnea as a marker of rapidity of disease progression, we found that the IL-6 intron 4GG genotype was the only genotype independently associated with lower DL(CO) levels. Carbon Monoxide 30-45 interleukin 6 Homo sapiens 163-167 11422212-6 2001 Following treatment with prednisolone, IL-6 mRNA levels in active LN patients decreased and AM mRNA levels increased to levels comparable to those in inactive LN and healthy volunteers. Prednisolone 25-37 interleukin 6 Homo sapiens 39-43 11231289-3 2001 Pharmacologic inhibition of either the ERK or the p38 MAPK pathway, using U0126 and SB203580, respectively, reduced interleukin-6 protein induction by at least 70%, and combined inhibition of both pathways fully blocked interleukin-6 protein expression and reduced interleukin-6 mRNA induction by more than 80%. SB 203580 84-92 interleukin 6 Homo sapiens 116-129 11314001-9 2001 However, the IL-6-induced Mcl-1 up-regulation was effectively attenuated in the presence of PI 3-K inhibitors, LY294002 and wortmannin. Wortmannin 124-134 interleukin 6 Homo sapiens 13-17 11288978-6 2001 Amiodarone-induced IL-6 production was inhibited by prednisolone at 10(-7) M. Electron microscopic examination revealed that the thyroid follicles in the suspension culture remained intact at 1 microM, but that cytotoxic effects (decreased microvilli and increased onion-like inclusion bodies) occurred at higher concentrations (10-25 microM). Prednisolone 52-64 interleukin 6 Homo sapiens 19-23 11288978-8 2001 Because amiodarone-induced IL-6 production was inhibited by prednisolone, it is reasonable to administer glucocorticoids to patients with amiodarone-induced destructive thyrotoxicosis (type II). Prednisolone 60-72 interleukin 6 Homo sapiens 27-31 11165942-2 2001 When added to MG-63 cells, tumor necrosis factor-alpha (TNF-alpha) had a stimulatory effect on the production of IL-6, and this elevation was significantly reduced by SB203580, a specific p38 MAPK inhibitor. SB 203580 167-175 interleukin 6 Homo sapiens 113-117 11165942-4 2001 Both the NF-kappaB inhibitors in the presence of SB203580 had a more inhibitory effect on IL-6 release. SB 203580 49-57 interleukin 6 Homo sapiens 90-94 12760489-2 2001 When added to cultures of cardiomyocytes, the combined agents (LPS/IFN-gamma or TNF-alpha/IFN-gamma) had stimulatory effect on the production of IL-6 and the elevation was significantly reduced by SB203580, a specific p38 MAPK inhibitor. SB 203580 197-205 interleukin 6 Homo sapiens 145-149 12760489-3 2001 SB203580 inhibited protein production and gene expression of IL-6 in a concentration-dependent manner. SB 203580 0-8 interleukin 6 Homo sapiens 61-65 11104703-5 2000 However, pretreatment with the proteasome inhibitor MG132 under conditions that prevented the IL-1beta-dependent activation of the nuclear factor NF-kappaB also blocked the inhibitory effect of IL-1beta on IL-6-activated STAT1. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 52-57 interleukin 6 Homo sapiens 206-210 11118064-6 2000 Inhibition of PI 3-K activity with wortmannin or Ly294002 blocked the antiapoptotic effect of IGF-I and the proliferative effect of IL-6 in the myeloma cell lines. Wortmannin 35-45 interleukin 6 Homo sapiens 132-136 11037876-1 2000 OBJECTIVE: Taurine chloramine (Tau-Cl) has been shown to inhibit the production of proinflammatory cytokines (interleukin-6 [IL-6] and IL-8) by fibroblast-like synoviocytes (FLS) isolated from rheumatoid arthritis (RA) patients. Taurine 11-18 interleukin 6 Homo sapiens 110-123 11037876-1 2000 OBJECTIVE: Taurine chloramine (Tau-Cl) has been shown to inhibit the production of proinflammatory cytokines (interleukin-6 [IL-6] and IL-8) by fibroblast-like synoviocytes (FLS) isolated from rheumatoid arthritis (RA) patients. Taurine 11-18 interleukin 6 Homo sapiens 125-129 11037876-1 2000 OBJECTIVE: Taurine chloramine (Tau-Cl) has been shown to inhibit the production of proinflammatory cytokines (interleukin-6 [IL-6] and IL-8) by fibroblast-like synoviocytes (FLS) isolated from rheumatoid arthritis (RA) patients. N-chlorotaurine 31-37 interleukin 6 Homo sapiens 110-123 11037876-1 2000 OBJECTIVE: Taurine chloramine (Tau-Cl) has been shown to inhibit the production of proinflammatory cytokines (interleukin-6 [IL-6] and IL-8) by fibroblast-like synoviocytes (FLS) isolated from rheumatoid arthritis (RA) patients. N-chlorotaurine 31-37 interleukin 6 Homo sapiens 125-129 11037876-3 2000 METHODS: The effects of Tau-Cl on 1) the transcription of genes coding for IL-6 and IL-8, and 2) the activity of nuclear factor kappaB (NF-kappaB) and activator protein 1 (AP-1) transcription factors, which are crucial for the transcription of these cytokine genes, were investigated in FLS isolated from the synovial tissue of RA patients. N-chlorotaurine 24-30 interleukin 6 Homo sapiens 75-79 11037876-8 2000 Tau-Cl, but not Tau, reduced IL-1beta-triggered cytokine mRNA expression, exerting stronger inhibitory activity on the levels of IL-6 than on those of IL-8. N-chlorotaurine 0-6 interleukin 6 Homo sapiens 129-133 10873157-5 2000 Expression of IL-6 and IL-8 was sensitive to SB203580, the specific inhibitor of p38 mitogen-activated protein (MAP) kinase and PD98059, an inhibitor of MAP kinase kinase. SB 203580 45-53 interleukin 6 Homo sapiens 14-18 10902767-6 2000 RESULTS: Bucillamine (64 microM) significantly inhibited T cell proliferation and the production of IL-2, IFNgamma, TNFalpha, and IL-6, whereas it had no inhibitory effects on the production of IL-4 and IL-5 in the cultures with anti-CD3 plus anti-CD26 mAb. bucillamine 9-20 interleukin 6 Homo sapiens 130-134 10834930-3 2000 We now demonstrate that epinephrine as well as norepinephrine can induce IL-6 in an endothelial cell line (HMEC-1). Epinephrine 24-35 interleukin 6 Homo sapiens 73-77 10847630-4 2000 EMSAs demonstrated that AdiNOS inhibits IL-6-induced Stat3 activation and that this inhibition is reversible in the presence of the NOS inhibitor N(G)-monomethyl-L-arginine (L-NMA). adinos 24-30 interleukin 6 Homo sapiens 40-44 10748190-6 2000 UV-induced IL-6 release is mediated via NFkappaB since the NFkappaB inhibitor MG132 or transfection of cells with a super-repressor form of the NFkappaB inhibitor IkappaB reduced IL-6 release. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 78-83 interleukin 6 Homo sapiens 11-15 10748190-6 2000 UV-induced IL-6 release is mediated via NFkappaB since the NFkappaB inhibitor MG132 or transfection of cells with a super-repressor form of the NFkappaB inhibitor IkappaB reduced IL-6 release. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 78-83 interleukin 6 Homo sapiens 179-183 10727406-6 2000 Furthermore, inhibition of p38 kinase activity with the inhibitor SB203580 did not block STAT3 Ser(727) phosphorylation but rather increased both basal as well as IL-6-induced STAT3 transactivation, indicating that p38 may act as a negative regulator of IL-6-induced STAT3 transactivation through a presently unknown mechanism. SB 203580 66-74 interleukin 6 Homo sapiens 163-167 10727406-6 2000 Furthermore, inhibition of p38 kinase activity with the inhibitor SB203580 did not block STAT3 Ser(727) phosphorylation but rather increased both basal as well as IL-6-induced STAT3 transactivation, indicating that p38 may act as a negative regulator of IL-6-induced STAT3 transactivation through a presently unknown mechanism. SB 203580 66-74 interleukin 6 Homo sapiens 254-258 12501620-2 2000 The results showed that there were basic production of interleukin-6(IL-6) and tumor necrosis factor-alpha (TNF-alpha) on MC in the control group without LPS, that high-concentration heparin(500 U/ml) increased the effects of LPS on MC, and that low-concentration heparin (5 U/ml) conversely inhibited the effects of LPS on MC. Methylcholanthrene 122-124 interleukin 6 Homo sapiens 55-68 12501620-2 2000 The results showed that there were basic production of interleukin-6(IL-6) and tumor necrosis factor-alpha (TNF-alpha) on MC in the control group without LPS, that high-concentration heparin(500 U/ml) increased the effects of LPS on MC, and that low-concentration heparin (5 U/ml) conversely inhibited the effects of LPS on MC. Methylcholanthrene 122-124 interleukin 6 Homo sapiens 69-73 10823386-3 2000 MAIN RESULTS: Catecholamines (epinephrine, norepinephrine, isoproterenol, and dopamine) in general inhibit tumor necrosis factor-alpha (TNF) production and may enhance interleukin-6 (IL-6) and IL-10 production. Epinephrine 30-41 interleukin 6 Homo sapiens 168-181 10620700-2 2000 Pretreatment of RSF with a specific p38 MAP kinase inhibitor, SB203580, blocked the induction of IL-6 and IL-8 without affecting nuclear translocation of nuclear factor kappaB (NF-kappaB) or IL-6 and IL-8 mRNA levels. (3r,3as,6ar)-Hexahydrofuro[2,3-B]furan-3-Ol 16-19 interleukin 6 Homo sapiens 97-101 10620700-2 2000 Pretreatment of RSF with a specific p38 MAP kinase inhibitor, SB203580, blocked the induction of IL-6 and IL-8 without affecting nuclear translocation of nuclear factor kappaB (NF-kappaB) or IL-6 and IL-8 mRNA levels. SB 203580 62-70 interleukin 6 Homo sapiens 97-101 10926317-3 2000 Here we examined the effects of IL-6 on propiomelanocortin (POMC) expression and ACTH production in corticotroph adenoma cells in vitro. propiomelanocortin 40-58 interleukin 6 Homo sapiens 32-36 10613737-6 2000 [(3)H]Taurocholate ([(3)H]TC) uptake decreased in WIF-B cells exposed to either TNF-alpha (54% of control), IL-1beta (78%), IL-6 (55%) as single additives, or in triple combination (TCC) (43%). [(3)h]taurocholate 0-18 interleukin 6 Homo sapiens 124-128 12075433-1 2000 Wortmannin, a specific inhibitor of PI-3 kinase, antagonized the inhibitory effect of IL-6 in M1 acute myeloid leukemia cells. Wortmannin 0-10 interleukin 6 Homo sapiens 86-90 12075433-2 2000 Electrophoretic mobility shift assays revealed that wortmannin selectively reduced the IL-6-induced activation of Stat3, while Stat3 plays a central role in IL-6-induced growth-arrest and terminal differentiation of M1 cells. Wortmannin 52-62 interleukin 6 Homo sapiens 87-91 10559516-7 1999 Vitamin E, at the doses used, did not significantly change the spontaneous production but dose-dependently inhibited the IL-1beta-induced production of inflammatory cytokine IL-6. Vitamin E 0-9 interleukin 6 Homo sapiens 174-178 10586114-7 1999 The IL-1-enhanced IL-6 protein secretion was strongly reduced by SB203580 and PD98059. SB 203580 65-73 interleukin 6 Homo sapiens 18-22 10630576-7 1999 Furthermore, vitamin E decreased PCB 77-mediated production of the inflammatory cytokine IL-6. Vitamin E 13-22 interleukin 6 Homo sapiens 89-93 10363271-7 1999 After treatment with prednisolone, her manifestations and CSF findings including IL-6 resolved. Prednisolone 21-33 interleukin 6 Homo sapiens 81-85 10667331-1 1999 In HepG2 cells phosphorothioate modified antisense oligonucleotides against a sequence in the Ca2+ binding domain (AS-Ca2+) of type II sPLA2 mRNA restrained IL-6-induced synthesis of sPLA2 protein, sPLA2 mRNA (northern blot), and abolished IL-6 stimulated PGE2 release. Arsenic 115-117 interleukin 6 Homo sapiens 157-161 10667331-1 1999 In HepG2 cells phosphorothioate modified antisense oligonucleotides against a sequence in the Ca2+ binding domain (AS-Ca2+) of type II sPLA2 mRNA restrained IL-6-induced synthesis of sPLA2 protein, sPLA2 mRNA (northern blot), and abolished IL-6 stimulated PGE2 release. Arsenic 115-117 interleukin 6 Homo sapiens 240-244 10026370-5 1999 Spontaneous secretion of IL-1beta or IL-6 by MC of preterm neonates was less inhibited by dexamethasone as compared with cells from adults. Methylcholanthrene 45-47 interleukin 6 Homo sapiens 37-41 10026370-7 1999 As for term newborns, MC were more sensitive to the inhibitory effect of the drug on LPS-induced IL-6 production than cells of adults. Methylcholanthrene 22-24 interleukin 6 Homo sapiens 97-101 9888410-10 1999 RESULTS: There was a significant decrease in monocyte TNF, IL-8, and IL-6 production after OTZ therapy. otz 91-94 interleukin 6 Homo sapiens 69-73 9852582-4 1998 Here, we show, using current- and voltage-clamp recordings, that chronic IL-6 treatment of developing cerebellar granule neurons increases the membrane and current response to NMDA and that these effects are the primary mechanism through which IL-6 produces an enhanced calcium signal to NMDA. N-Methylaspartate 176-180 interleukin 6 Homo sapiens 73-77 9852582-4 1998 Here, we show, using current- and voltage-clamp recordings, that chronic IL-6 treatment of developing cerebellar granule neurons increases the membrane and current response to NMDA and that these effects are the primary mechanism through which IL-6 produces an enhanced calcium signal to NMDA. N-Methylaspartate 176-180 interleukin 6 Homo sapiens 244-248 9747588-0 1998 Release of inflammatory mediators (PGE2, IL-6) by fenofibric acid-photosensitized human keratinocytes and fibroblasts. fenofibric acid 50-65 interleukin 6 Homo sapiens 41-45 9767420-3 1998 The anti-inflammatory cytokine IL-1Ra is increased by captopril, whereas IL-6 production is decreased by valsartan. Valsartan 105-114 interleukin 6 Homo sapiens 73-77 9527063-9 1998 RESULTS: An elevated level of bioactive IL-6 was detected in every patient with CC and in 13 of 14 patients with HCC, 14 of 26 patients with MCRC, 2 of 5 patients with BBD, and 3 of 35 healthy adults. 5-tert-butyl-1,3-benzodioxole 168-171 interleukin 6 Homo sapiens 40-44 9575555-2 1998 Here we show that inhibitors of ADP-ribosylation namely nicotinamide and meta-iodobenzylguanidine prevent production of TNF-alpha and IL-6 at the protein and mRNA level. Niacinamide 56-68 interleukin 6 Homo sapiens 134-138 9412820-7 1997 In addition, both PGE1 and SM-6 increased production of TGF-beta 1, IL-8 and IL-6 and levels of cAMP in both cell types. SM 10906 27-31 interleukin 6 Homo sapiens 77-81 9256609-10 1997 Prednisolone inhibited the production of IL-1 alpha, IL-1 beta, IL-6 and TNF alpha. Prednisolone 0-12 interleukin 6 Homo sapiens 64-68 9043938-12 1997 We conclude that retinol and retinoid acids (13-cis, all trans-) may alter the human colonic immune system possibly via IL-1 cytokine, but not via IL-6. retinoid acids 29-43 interleukin 6 Homo sapiens 147-151 21533366-14 1997 The significant differences between the two Arms were only: the CD8(+) lymphocytes were decreased in the patients treated with SPG and increased in controls; serum levels of IL-1 alpha was lower in patients treated with SPG than in the control group; the production in culture of IL-1 alpha was higher in Arm A than in Arm B and IL-6 was higher in Arm B than in Arm A. spirogermanium 220-223 interleukin 6 Homo sapiens 329-333 9058440-12 1997 Plasma IL-6 and IL-8 levels were marginally higher before the operation and were significantly higher on POD1 in the TPN group than in the oral group. 2',3'-dialdehyde NADP 117-120 interleukin 6 Homo sapiens 7-11 9058440-13 1997 The IL-6 levels showed a positive regression relation with the amounts of blood loss only in the TPN group (P < 0.05, r = 0.881). 2',3'-dialdehyde NADP 97-100 interleukin 6 Homo sapiens 4-8 9342758-6 1997 Cytokine secretion capacity was significantly altered in LASM which exhibited reduced TNF alpha and IL-6, but elevated IL-1 alpha secretion when compared to control SM. lasm 57-61 interleukin 6 Homo sapiens 100-104 8878515-3 1996 These data suggest that increased IL-6 production after stimulation by either interleukin-1 or tumor necrosis factor-alpha would result in complex formation with sIL-6R, rapid uptake, and further synthesis of this cytokine. sil-6r 162-168 interleukin 6 Homo sapiens 34-38 8822942-6 1996 Importantly, culture of MM cells with RB antisense, but not RB sense, oligonucleotide (ODN) triggered IL-6 secretion and proliferation in MM cells; however, proliferation was only partially inhibited by neutralizing anti-IL-6 monoclonal antibody (MoAb). odn 87-90 interleukin 6 Homo sapiens 102-106 8822942-6 1996 Importantly, culture of MM cells with RB antisense, but not RB sense, oligonucleotide (ODN) triggered IL-6 secretion and proliferation in MM cells; however, proliferation was only partially inhibited by neutralizing anti-IL-6 monoclonal antibody (MoAb). odn 87-90 interleukin 6 Homo sapiens 221-225 8843757-5 1996 A positive correlation was observed between peak plasma epinephrine or norepinephrine and IL-6 levels at 15 min. Epinephrine 56-67 interleukin 6 Homo sapiens 90-94 8797615-16 1996 The data indicate that one or more plasma factors are responsible for stimulation of hypoxia-induced erythropoietin production in the Hep 3B cell line and suggest a possible role for IL-6 in the regulation of erythropoletin production in critically ill children with sepsis or septic shock. erythropoletin 209-223 interleukin 6 Homo sapiens 183-187 8671470-8 1996 However, average follicular phase serum IL-6 concentrations were higher in OHSS (8.71 +/- 0.41 pg/ml) and COH (7.66 +/- 0.38 pg/ml) patients than in normally menstruating women (4.34 +/- 0.99 pg/ml) (P < 0.0001). coh 106-109 interleukin 6 Homo sapiens 40-44 8671470-9 1996 Pre-ovulatory serum IL-6 concentrations were also higher in OHSS (9 +/- 0.94 pg/ml) and COH (7.3 +/- 0.97 pg/ml) patients than in controls (4.57 +/- 1.1 pg/ml) (P < 0.01 and P < 0.04 respectively). coh 88-91 interleukin 6 Homo sapiens 20-24 8666316-3 1996 The induction of IL-6 by IFN-alpha was completely suppressed by the intravenous administration of gabexate mesilate (GM), a serine protease inhibitor. Gabexate 98-115 interleukin 6 Homo sapiens 17-21 8666316-3 1996 The induction of IL-6 by IFN-alpha was completely suppressed by the intravenous administration of gabexate mesilate (GM), a serine protease inhibitor. Gabexate 117-119 interleukin 6 Homo sapiens 17-21 8666316-4 1996 The mechanism whereby GM suppresses the elevation in circulating IL-6 levels seems to be the inhibition of IL-6 production at the messenger RNA level. Gabexate 22-24 interleukin 6 Homo sapiens 65-69 8666316-4 1996 The mechanism whereby GM suppresses the elevation in circulating IL-6 levels seems to be the inhibition of IL-6 production at the messenger RNA level. Gabexate 22-24 interleukin 6 Homo sapiens 107-111 8666316-5 1996 Elevations of both serum C-reactive protein (CRP) levels and body temperature after GM-suppressed IFN-alpha injection suggest that the administration of GM by suppressing IL-6 production, may attenuate the IL-6-related responses induced by IFN-alpha injection. Gabexate 153-155 interleukin 6 Homo sapiens 171-175 8666316-5 1996 Elevations of both serum C-reactive protein (CRP) levels and body temperature after GM-suppressed IFN-alpha injection suggest that the administration of GM by suppressing IL-6 production, may attenuate the IL-6-related responses induced by IFN-alpha injection. Gabexate 153-155 interleukin 6 Homo sapiens 206-210 8666316-6 1996 In conclusion, we found that IL-6 was induced by IFN-alpha in vivo, and that this induction was completely abrogated by the administration of GM. Gabexate 142-144 interleukin 6 Homo sapiens 29-33 8722639-0 1996 The soluble form of the IL-6 receptor (sIL-6R alpha) is a potent growth factor for AIDS-associated Kaposi"s sarcoma (KS) cells; the soluble form of gp130 is antagonistic for sIL-6R alpha-induced AIDS-KS cell growth. sil-6r 39-45 interleukin 6 Homo sapiens 24-28 8689410-7 1996 RESULTS: Significant increases in HSF binding to [32P]labeled HSE were found at 30 minutes in nuclear extract and at 4 hours in both nuclear and cytosol extracts. Phosphorus-32 50-53 interleukin 6 Homo sapiens 34-37 8833207-12 1996 Only one patient treated with ibandronate showed an increase in IL-6 and CRP levels. Ibandronic Acid 30-41 interleukin 6 Homo sapiens 64-68 8704096-1 1996 We evaluate the influence of IL-4, IL-10 and TGF-beta upon the release of IL-1 alpha, tumor necrosis factor-alpha (TNF-alpha), and IL-6 by lipopolisaccharide (LPS, 1 microgram/ml) stimulated alveolar macrophages (AM). lps 159-162 interleukin 6 Homo sapiens 131-135 8575568-0 1995 Effect of erythromycin on Haemophilus influenzae endotoxin-induced release of IL-6, IL-8 and sICAM-1 by cultured human bronchial epithelial cells. Erythromycin 10-22 interleukin 6 Homo sapiens 78-82 8575568-5 1995 Incubation of the epithelial cultures in the presence of 0.1-10 micrograms.mL-1 erythromycin significantly blocked the HIE-induced release of IL-6, IL-8, and sICAM-1, at all concentrations of erythromycin investigated. Erythromycin 80-92 interleukin 6 Homo sapiens 142-146 7629516-0 1995 Ceramide induces interleukin 6 gene expression in human fibroblasts. Ceramides 0-8 interleukin 6 Homo sapiens 17-30 7629516-6 1995 Here we describe the effects of ceramide in another IL-1 beta-mediated process in these cells, the induction of IL-6 production. Ceramides 32-40 interleukin 6 Homo sapiens 112-116 7629516-8 1995 Both D-erythro-C2-ceramide (a cell-permeable analogue of natural ceramide) and D-threo-C2-ceramide were potent inducers of IL-6 production, while neither L isomer of ceramide was effective. Ceramides 18-26 interleukin 6 Homo sapiens 123-127 7629516-8 1995 Both D-erythro-C2-ceramide (a cell-permeable analogue of natural ceramide) and D-threo-C2-ceramide were potent inducers of IL-6 production, while neither L isomer of ceramide was effective. Ceramides 65-73 interleukin 6 Homo sapiens 123-127 7629516-9 1995 Compared with IL-1 beta-induced IL-6 production, cells treated with ceramide or exogenous sphingomyelinase induced 82 and 50% of maximal IL-1 beta-induced IL-6 levels by 6 h, respectively; by 24 h all three treatments induced similar levels of IL-6 production. Ceramides 68-76 interleukin 6 Homo sapiens 32-36 7629516-9 1995 Compared with IL-1 beta-induced IL-6 production, cells treated with ceramide or exogenous sphingomyelinase induced 82 and 50% of maximal IL-1 beta-induced IL-6 levels by 6 h, respectively; by 24 h all three treatments induced similar levels of IL-6 production. Ceramides 68-76 interleukin 6 Homo sapiens 155-159 7629516-9 1995 Compared with IL-1 beta-induced IL-6 production, cells treated with ceramide or exogenous sphingomyelinase induced 82 and 50% of maximal IL-1 beta-induced IL-6 levels by 6 h, respectively; by 24 h all three treatments induced similar levels of IL-6 production. Ceramides 68-76 interleukin 6 Homo sapiens 155-159 7629516-10 1995 Ceramide-induced IL-6 messenger RNA could be detected within 1 h of treatment and reached maximal levels by 24 h. These findings suggest that ceramide may play a role in the regulation of IL-6 gene expression. Ceramides 0-8 interleukin 6 Homo sapiens 17-21 7629516-10 1995 Ceramide-induced IL-6 messenger RNA could be detected within 1 h of treatment and reached maximal levels by 24 h. These findings suggest that ceramide may play a role in the regulation of IL-6 gene expression. Ceramides 0-8 interleukin 6 Homo sapiens 188-192 7629516-10 1995 Ceramide-induced IL-6 messenger RNA could be detected within 1 h of treatment and reached maximal levels by 24 h. These findings suggest that ceramide may play a role in the regulation of IL-6 gene expression. Ceramides 142-150 interleukin 6 Homo sapiens 17-21 7629516-10 1995 Ceramide-induced IL-6 messenger RNA could be detected within 1 h of treatment and reached maximal levels by 24 h. These findings suggest that ceramide may play a role in the regulation of IL-6 gene expression. Ceramides 142-150 interleukin 6 Homo sapiens 188-192 7763252-0 1995 Erythromycin suppresses interleukin 6 expression by human bronchial epithelial cells: a potential mechanism of its anti-inflammatory action. Erythromycin 0-12 interleukin 6 Homo sapiens 24-37 7763252-2 1995 Among those tested, erythromycin (EM) and clarithromycin (CAM) uniquely suppressed mRNA levels as well as the release of IL-6 at the therapeutic and non-cytotoxic concentration (10(-6)M). Erythromycin 20-32 interleukin 6 Homo sapiens 121-125 7763252-2 1995 Among those tested, erythromycin (EM) and clarithromycin (CAM) uniquely suppressed mRNA levels as well as the release of IL-6 at the therapeutic and non-cytotoxic concentration (10(-6)M). Erythromycin 34-36 interleukin 6 Homo sapiens 121-125 7536243-6 1995 The suppression of lymphocyte blastogenesis in vitro by cyclosporine or prednisolone was restored by addition of interleukin (IL)-1, IL-2, IL-4, IL-5 or IL-6. Prednisolone 72-84 interleukin 6 Homo sapiens 153-157 7708743-3 1995 In vivo transfection of the human interleukin 6 gene into the tumor site reduced methylcholanthrene-induced fibrosarcoma growth, and a combination of murine tumor necrosis factor alpha and interferon gamma genes inhibited growth of a renal carcinoma tumor model (Renca). Methylcholanthrene 81-99 interleukin 6 Homo sapiens 34-47 7800135-3 1994 The IL-6 immunoreactivity eluted from a Sephadex G-100 column in a major peak corresponding to an M(r) of 30,000 and a lesser peak corresponding to an M(r) of 50,000. sephadex 40-54 interleukin 6 Homo sapiens 4-8 8189461-7 1994 Interleukin 6 levels correlated positively with protein turnover (phenylalaninemia) and catabolism (3-methylhistidine/creatinine ratio) and negatively with levels of fibronectin and transthyretin. 3-methylhistidine 100-117 interleukin 6 Homo sapiens 0-13 8130044-12 1994 We conclude that anaesthesia with alfentanil and propofol diminished release of IL-6 in response to abdominal surgery compared with isoflurane and that this reduction was an effect of alfentanil. Propofol 49-57 interleukin 6 Homo sapiens 80-84 8267048-5 1993 RESULTS: 5-Hydroxyeicosatetraenoic acid production was significantly increased by interleukin-1 beta and interleukin-6 treatment in amnion, chorion, and decidual cells. 5-hydroxy-6,8,11,14-eicosatetraenoic acid 9-39 interleukin 6 Homo sapiens 105-118 8230261-0 1993 Phase I study of bryostatin 1: assessment of interleukin 6 and tumor necrosis factor alpha induction in vivo. bryostatin 1 17-29 interleukin 6 Homo sapiens 45-90 8230261-15 1993 IL-6 and TNF-alpha plasma concentrations may be useful in monitoring biological activity of bryostatin 1. bryostatin 1 92-104 interleukin 6 Homo sapiens 0-4 8309727-7 1993 Among the same family of antibiotics such as macrolides, differences on cytokine modulation were observed: spiramycin and erythromycin increased IL-6 production while roxithromycin did not exert any significant effect. Erythromycin 122-134 interleukin 6 Homo sapiens 145-149 8439987-4 1993 Generally, arabinogalactan pretreatment induced an increased release of interferon gamma (IFN gamma), tumor necrosis factor alpha, interleukin-1 beta (IL-1 beta) and IL-6 but only IFN gamma was involved in enhancement of NK cytotoxicity since cytotoxicity enhancement of PBMC and PNAC but not that of monocytes could be blocked when anti-IFN gamma antibodies were present during pretreatment. arabinogalactan 11-26 interleukin 6 Homo sapiens 166-170 1610348-4 1992 Pulse-chase experiments using [32P]-orthophosphate or [35S]-methionine as tracers indicated that phosphorylation of IL-6 occurred prior to its O-glycosylation suggesting that the de novo synthesized IL-6 polypeptide is rapidly, perhaps even cotranslationally, phosphorylated at an intravesicular site (in the endoplasmic reticulum and/or Golgi). Phosphorus-32 31-34 interleukin 6 Homo sapiens 116-120 1610348-5 1992 When IL-1 alpha-induced fibroblasts were exposed to cycloheximide there was enhancement of the net de novo synthesis and secretion of IL-6 as followed by [35S]-methionine labeling ("superinduction") but the secreted cytokine was no longer phosphorylated as monitored by [32P] labeling. Phosphorus-32 271-274 interleukin 6 Homo sapiens 134-138 1350713-2 1992 The IL-6 and C-reactive protein (CRP) levels, which were extremely high before treatment, declined rapidly with administration of prednisolone. Prednisolone 130-142 interleukin 6 Homo sapiens 4-8 1573267-7 1992 Thioglycollate-elicited peritoneal exudate macrophages incubated with native doublet MIP 1-secreted bioactive TNF and IL-6, as well as immunoreactive IL-1 alpha, and these effects were enhanced significantly when the cells were costimulated with IFN-gamma. Thioglycolates 0-14 interleukin 6 Homo sapiens 118-122 1759822-5 1991 Spiramycin and, to a lesser extent, erythromycin increased total IL-6 production without affecting IL-1 alpha, IL-1 beta, or tumor necrosis factor alpha production, whereas roxithromycin had no effect. Erythromycin 36-48 interleukin 6 Homo sapiens 65-69 1718855-3 1991 Although MH166 completely neutralized hIL-6 activity in vitro, treatment in vivo with hIL-6 and MH166 combined unexpectedly increased both anti-dinitrophenyl (DNP) and anti-sheep red blood cell (SRBC) antibody production more than treatment with IL-6 alone did. dnp 159-162 interleukin 6 Homo sapiens 86-91 1913856-5 1991 This HSF activity was greatly reduced, however, during recentrifugation in sucrose density gradient and, in addition, the residual activity was not recovered in 8 S fractions. Sucrose 75-82 interleukin 6 Homo sapiens 5-8 2033081-6 1991 The bulk of fibroblast-derived IL-6 eluted in the size range 45-85 kDa from a Sephadex G-200 gel filtration column further indicating that fibroblast-derived IL-6 was largely multimeric even in dilute solutions. sephadex 78-86 interleukin 6 Homo sapiens 31-35 1645270-8 1991 In contrast, non-cognate Th-independent exogenous interleukin 6-induced differentiation of B7+ B cells into ISC was not inhibited by mAb to either molecule. Thorium 25-27 interleukin 6 Homo sapiens 50-63 1995637-8 1991 Intracellular limited proteolysis of IL-6 could be demonstrated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. polyacrylamide gels 90-108 interleukin 6 Homo sapiens 37-41 1686972-5 1991 Moreover, the action of cytokines/lymphokines having DP IV susceptible bonds, as IL-1, IL-2 and IL-6, on lymphocyte proliferation, was found to be suppressed by specific inhibitors of DP IV as well as AP-N. dp 53-55 interleukin 6 Homo sapiens 96-100 1686972-5 1991 Moreover, the action of cytokines/lymphokines having DP IV susceptible bonds, as IL-1, IL-2 and IL-6, on lymphocyte proliferation, was found to be suppressed by specific inhibitors of DP IV as well as AP-N. dp 184-186 interleukin 6 Homo sapiens 96-100 2226642-7 1990 Since the inhibition of mitogenic stimulation by poly(I:C) is completely overcome by antisera recognizing interferon-beta (IFN-beta) and interleukin-6 (IL-6), we tested the effect of IL-6 and IFN-beta on EGF mitogenicity. Poly I-C 49-58 interleukin 6 Homo sapiens 137-150 2346722-2 1990 Recombinant human (rh) IL-1 alpha, IL-1 beta and TNF-alpha augmented production of IL-6 in human MC. Methylcholanthrene 97-99 interleukin 6 Homo sapiens 83-87 2346722-6 1990 IL-1 alpha, IL-1 beta and TNF-alpha enhanced 3H-TdR uptake in myeloma cells through IL-6, as antibodies to IL-6 completely abolished the DNA synthesis induced by culture supernatants of MC exposed to these cytokines. Methylcholanthrene 186-188 interleukin 6 Homo sapiens 84-88 2346722-6 1990 IL-1 alpha, IL-1 beta and TNF-alpha enhanced 3H-TdR uptake in myeloma cells through IL-6, as antibodies to IL-6 completely abolished the DNA synthesis induced by culture supernatants of MC exposed to these cytokines. Methylcholanthrene 186-188 interleukin 6 Homo sapiens 107-111 2346722-10 1990 Further data demonstrated that human MC were able to induce IL-6 production in MSC. Methylcholanthrene 37-39 interleukin 6 Homo sapiens 60-64 2105658-4 1990 After the addition of a highly concentrated human monocyte-conditioned medium (MCM) or various cytokines to these prelabeled cells, [14C]glucose release was stimulated by MCM and recombinant human interleukin 6 (IL-6) but was not stimulated by other cytokines tested. Carbon-14 133-136 interleukin 6 Homo sapiens 197-210 2105658-4 1990 After the addition of a highly concentrated human monocyte-conditioned medium (MCM) or various cytokines to these prelabeled cells, [14C]glucose release was stimulated by MCM and recombinant human interleukin 6 (IL-6) but was not stimulated by other cytokines tested. Carbon-14 133-136 interleukin 6 Homo sapiens 212-216 9201266-1 1997 Our previous studies demonstrated that both in vivo and in vitro 3,4-dichloro-propionanilide (propanil) exposure inhibited interleukin-6 (IL-6) and tumor necrosis factor (TNF) production by adherent thioglycollate-elicited peritoneal cells (macrophages) after lipopolysaccharide (LPS) stimulation. Thioglycolates 199-213 interleukin 6 Homo sapiens 138-142 34952465-10 2022 In vivo study showed that lenalidomide inhibited pro-inflammatory cytokines TNF-alpha and IL-6 while enhanced anti-fibrotic cytokines IFN-gamma and IL-10 in bleomycin-induced inflammation model, and attenuated pulmonary fibrosis and collagen deposition in the following fibrosis stage. Lenalidomide 26-38 interleukin 6 Homo sapiens 90-94 34570917-17 2022 Both Amlexanox and BAY 11-7082 inhibited IFN-beta, TNF, and IL-6 production triggered by ISD and cyclic dinucleotides transfection. Isosorbide Dinitrate 89-92 interleukin 6 Homo sapiens 60-64 34570917-17 2022 Both Amlexanox and BAY 11-7082 inhibited IFN-beta, TNF, and IL-6 production triggered by ISD and cyclic dinucleotides transfection. cyclic dinucleotides 97-117 interleukin 6 Homo sapiens 60-64 34614305-11 2022 RESULTS: Imiquimod significantly inhibited the activity of tyrosinase activity and decreased melanin content in melanocytes and significantly increased apoptosis and IL-6, IL-8, and sICAM-1 production in melanocytes. Imiquimod 9-18 interleukin 6 Homo sapiens 166-170 34936813-10 2022 Conclusions: Inhibition of mTOR signaling pathway suppressed the elevation of inflammatory cytokines IL-6, IL-8, and the angiogenic agent VEGF induced by 7-KC. 7-ketocholesterol 154-158 interleukin 6 Homo sapiens 101-105 34984290-5 2021 Similar results followed the exposure of IL-6 to N-chlorotaurine (NCT) and hypobromous acid (HOBr), two other reactive species produced in vivo. N-chlorotaurine 49-64 interleukin 6 Homo sapiens 41-45 34984290-5 2021 Similar results followed the exposure of IL-6 to N-chlorotaurine (NCT) and hypobromous acid (HOBr), two other reactive species produced in vivo. N-chlorotaurine 66-69 interleukin 6 Homo sapiens 41-45 34752597-3 2021 Butyrate enters the cells through the Solute Carrier Family 5 Member 8 (SLC5A8) transporters, then works as a histone deacetylase inhibitor (HDAC) that inhibits the activation of Nuclear factor-kappaB (NF-kappaB), which down-regulates the expression of IL-1beta, IL-6, TNF-alpha. Butyrates 0-8 interleukin 6 Homo sapiens 263-267 34890489-6 2022 RT-PCR and ELISA results have shown that mature IL-6 mRNA was efficiently transfected into MSCs using a lipofectamine based method. Lipofectamine 104-117 interleukin 6 Homo sapiens 48-52 34925374-12 2021 In vitro studies showed that Par2-/- BMDM produced less IL6 and IL12p40 than Par2 +/+ BMDM after poly I:C stimulation. Poly I-C 97-105 interleukin 6 Homo sapiens 56-59 34925374-13 2021 In addition, activation of PAR2 on Par2 +/+ BMDM increased poly I:C induction of IL6 and IL12p40 compared to poly I:C stimulation alone. Poly I-C 59-67 interleukin 6 Homo sapiens 81-84 34754315-10 2021 Molecular docking results showed that quercetin, luteolin, kaempferol, tanshinone IIa, wogonin, naringenin, nobiletin, dihydrotanshinlactone, beta-sitosterol, and salviolone have good affinity with core target proteins IL6, PTGS2, MAPK1, MAPK3, and CGRP1. dihydrotanshinlactone 119-140 interleukin 6 Homo sapiens 219-222 34713863-7 2021 The levels of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) were much lower after propofol anaesthesia than after inhalation anaesthesia (SMD: -2.027, 95% CI: -3.748- -0.307, P = .021; SMD: -0.68, 95% CI: -0.93- -0.43, P < .001). Propofol 102-110 interleukin 6 Homo sapiens 14-27 34713863-7 2021 The levels of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) were much lower after propofol anaesthesia than after inhalation anaesthesia (SMD: -2.027, 95% CI: -3.748- -0.307, P = .021; SMD: -0.68, 95% CI: -0.93- -0.43, P < .001). Propofol 102-110 interleukin 6 Homo sapiens 29-33 34617520-6 2021 RESULTS AND CONCLUSION: The combination of PFLC with AFMC caused a reduction of ROS generation, reduced IL-6 production and suppressed the expression of COX-2. afmc 53-57 interleukin 6 Homo sapiens 104-108 34820310-9 2021 Anthocyanin and ternatin were then predicted to be able to influence any inhibitory activity of TNF-alphaR, MMP-9, and IL-6; increase IL-10; and increase HBD2 binding affinity values negatively. Anthocyanins 0-11 interleukin 6 Homo sapiens 119-123 34603607-8 2021 The tumor necrosis factor-alpha and interleukin-6 levels increased in cells co-treated with LPS under hyperglycemic conditions compared to normoglycemic conditions, and these increases were decreased by hesperetin treatment. hesperetin 203-213 interleukin 6 Homo sapiens 36-49 34171447-10 2021 Moreover, inactivation of p38MAPK with specific inhibitor (SB203580) attenuated IL-6 induced NED of LNCaP cells. SB 203580 59-67 interleukin 6 Homo sapiens 80-84 34080237-6 2021 Compared with baseline, serum levels of IL-6, TNF-alpha, MCP-1 and CRP were significantly reduced in patients receiving curcuminoids (p < .05) without any significant changes in placebo group; however, changes in the activities of GPx and SOD in serum were not significant between two groups. Diarylheptanoids 120-132 interleukin 6 Homo sapiens 40-44 34332517-6 2021 RESULTS: Through meta-analysis, this study found that arsenic could promote the phosphorylation of STAT3 (SMD=4.21, 95%CI (1.05, 7.37)), and increase IL-6 and p-JAK2, Vimentin, VEGF expression levels, thereby inducing malignant cell proliferation. Arsenic 54-61 interleukin 6 Homo sapiens 150-154 34332517-7 2021 In addition, this study also found that arsenic exposure dose (<5 mumol m-3), time(<24 h) and cell type were important sources of heterogeneity in the process of exploring the effects of arsenic on p-STAT3, IL-6 and p-JAK2. Arsenic 40-47 interleukin 6 Homo sapiens 207-211 34336088-0 2021 Carbon Monoxide-Releasing Molecule-2 Ameliorates Particulate Matter-Induced Aorta Inflammation via Toll-Like Receptor/NADPH Oxidase/ROS/NF-kappaB/IL-6 Inhibition. Carbon Monoxide 0-15 interleukin 6 Homo sapiens 146-150 34114392-6 2021 RESULTS: The results showed that BYF, BJF and YZF treatment strongly decreased the CSE-induced secretion of interleukin (IL)-6, IL-8, tumor necrosis factor-alpha and matrix metalloproteinase-9 by THP-1 cells. yzf 46-49 interleukin 6 Homo sapiens 108-126 34073895-4 2021 Pretreatment with 20 muM artemisinin weakened LPS-induced inflammatory damage in pMECs and decreased mRNA expression abundance and the content of inflammatory factors (IL-1beta, IL-6, and TNF-alpha) in pMECs (p < 0.05). artemisinin 25-36 interleukin 6 Homo sapiens 178-182 34589729-6 2021 Meta-analysis showed increased IL-6 concentrations in the offspring of poly(I:C) exposed mothers. Poly I-C 71-80 interleukin 6 Homo sapiens 31-35 34589729-8 2021 Furthermore, poly(I:C) administration during mid-gestation was associated with higher IL-6 concentrations in the offspring. Poly I-C 13-22 interleukin 6 Homo sapiens 86-90 35568074-5 2022 Further study showed that Anlotinib-induced PD-L1 expression was regulated by autocrine IL-6 mediated JAK2/STAT3 signaling pathways. anlotinib 26-35 interleukin 6 Homo sapiens 88-92 35578571-14 2022 This study is the first evidence that the IL-6/gp130 axis offers a potential therapeutic target in PDAC with N-inv. pdac 99-103 interleukin 6 Homo sapiens 42-46 35605028-0 2022 APE1 shRNA-loaded cancer stem cell-derived extracellular vesicles reverse Erlotinib resistance in non-small cell lung cancer via the IL-6/STAT3 signalling. Erlotinib Hydrochloride 74-83 interleukin 6 Homo sapiens 133-137 35605028-1 2022 OBJECTIVE: Apurinic endonuclease 1 (APE1) has been suggested as an oncogene of lung tumours and our bioinformatics analysis identified the association between Erlotinib resistance and interleukin-6 (IL-6). Erlotinib Hydrochloride 159-168 interleukin 6 Homo sapiens 184-197 35605028-1 2022 OBJECTIVE: Apurinic endonuclease 1 (APE1) has been suggested as an oncogene of lung tumours and our bioinformatics analysis identified the association between Erlotinib resistance and interleukin-6 (IL-6). Erlotinib Hydrochloride 159-168 interleukin 6 Homo sapiens 199-203 35605028-2 2022 Thus, we performed this work to delineate the mechanistic actions of APE1/IL-6 signalling in Erlotinib resistance of non-small cell lung cancer (NSCLC). Erlotinib Hydrochloride 93-102 interleukin 6 Homo sapiens 74-78 35605028-10 2022 APE1 shRNA was demonstrated to restrict the Erlotinib resistance of NSCLC cells by inactivating the IL-6/STAT3 signalling. Erlotinib Hydrochloride 44-53 interleukin 6 Homo sapiens 100-104 35379924-8 2022 Meanwhile, 27-hydroxycholesterol induced the secretion of FGF2 and IL-6, which contributed to the expression of snail and vimentin. 27-hydroxycholesterol 11-32 interleukin 6 Homo sapiens 67-71 35379924-12 2022 These results indicated that 27-hydroxycholesterol linked high cholesterol and LAC metastasis by regulating NFkappaB/PPIB axis and the secretion of FGF2 and IL-6. 27-hydroxycholesterol 29-50 interleukin 6 Homo sapiens 157-161 35408478-8 2022 Moreover, theasaponin E1 reduced inflammation by suppressing the Nf-kB pathway and dose-dependently reducing the levels of inflammatory cytokines such as IL-1beta, IL-6, and TNF-alpha etc. theasaponin E1 10-24 interleukin 6 Homo sapiens 164-168 35122928-5 2022 Intriguingly, inhibition of HO-1 activity mitigated cell viability loss and IL-6 expression in CdCl2-treated cells. Cadmium Chloride 95-100 interleukin 6 Homo sapiens 76-80 35091276-10 2022 Astaxanthin significantly reduced blood interleukin-6 concentration in T2DM patients (weighted mean difference: -0.70 pg/mL; 95% CI, -1.29 to -0.11 pg/mL; P = .02). astaxanthine 0-11 interleukin 6 Homo sapiens 40-53 35209199-7 2022 In M5-treated HaCaT cells, coptisine decreased the production of IL-6, MIP-3alpha/CCL20, IP-10/CXCL10, and ICAM-1 and suppressed the NF-kappaB signaling pathway. coptisine 27-36 interleukin 6 Homo sapiens 65-69 35039330-6 2022 Consistently, BCL6 expression was sustained following T cell activation of GPA naive CD4 T cells and in vitro TFH differentiation of these cells resulted in significant increases in the production TFH-related cytokines IL-21 and IL-6. tfh 110-113 interleukin 6 Homo sapiens 229-233 35039330-6 2022 Consistently, BCL6 expression was sustained following T cell activation of GPA naive CD4 T cells and in vitro TFH differentiation of these cells resulted in significant increases in the production TFH-related cytokines IL-21 and IL-6. tfh 197-200 interleukin 6 Homo sapiens 229-233 35115578-10 2022 The dimensions of response to the exercises observed through the changes in the concentration of 25(OH)D3, PTH, NEFA and glycerol were associated with the significant increases of IL-6 level. Calcifediol 97-105 interleukin 6 Homo sapiens 180-184 35061945-5 2022 Our previous work showed that a novel anthranilate analogue (SI-W052) inhibited lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 on microglia. anthranilic acid 38-50 interleukin 6 Homo sapiens 151-169 35061945-9 2022 Our signaling study further indicates that SI-W052 inhibits the upregulation of ER-stress marker genes, including Atf4 and sXbp1/tXbp1, explaining compound activity against IL-6. Silicon 43-45 interleukin 6 Homo sapiens 173-177 35061945-14 2022 Our knockdown experiment further verifies the important role of TEX264 in SI-W052 activity against IL-6 and ER-stress. Silicon 74-76 interleukin 6 Homo sapiens 99-103 35088229-10 2022 Meanwhile, miR-128-3p was negatively associated with blood lipid level (LDL-C), inflammatory cytokines (TNF-alpha, IL-1beta, IL-6), cell adhesion molecules (VCAM-1, ICAM-1), and Gensini score (all P < 0.05) in CHD patients. mir-128-3p 11-21 interleukin 6 Homo sapiens 125-129 35163148-8 2022 We found that sENG increased the gene expression of VEGF-A, pro-inflammatory cytokines/inflammasome mediators (TNF-alpha, IL-6, NLRP3, ASC, Caspase-1, and IL-1beta), and proteolytic enzyme (MMP-9) in BV2 microglia. seng 14-18 interleukin 6 Homo sapiens 122-126 35154692-7 2022 In this study, we found that acetate, propionate, and butyrate decreased IL-1beta-induced production of CXCL2 ex vivo and IL-8 and IL-6 in vitro significantly (p < .05). Butyrates 54-62 interleukin 6 Homo sapiens 131-135 34983106-5 2022 In vitro, polyinosinic:polycytidylic acid (Poly I-C) treatment markedly enhanced the production of SAA1 from AECs, which was further augmented by neutrophils; SAA1 could induce the production of interleukin (IL)-6, IL-8, and S100 calcium-binding protein A9 from AECs. Poly I-C 43-51 interleukin 6 Homo sapiens 195-213 35130734-9 2022 Additionally, we found that butein inhibited the invasion of 143B cells stimulated with IL-6 via the p-STAT3-MMP9 signaling pathway. butein 28-34 interleukin 6 Homo sapiens 88-92