PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
34738194-1	2022	SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase (dNTPase) that restricts viral replication in infected cells and limits the sensitivity to cytarabine by hydrolysing its active metabolite, as recently shown in acute myeloid leukemia.	Cytarabine	152-162	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
33235905-3	2020	We provide a molecular explanation: the deoxyribonucleoside triphosphate (dNTP) hydrolase SAM and HD domain-containing protein 1 (SAMHD1) prevents the accumulation of toxic dNTP levels during purine nucleoside phosphorylase inhibition.	deoxyribonucleoside triphosphate	40-72	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	90-128
33235905-3	2020	We provide a molecular explanation: the deoxyribonucleoside triphosphate (dNTP) hydrolase SAM and HD domain-containing protein 1 (SAMHD1) prevents the accumulation of toxic dNTP levels during purine nucleoside phosphorylase inhibition.	deoxyribonucleoside triphosphate	40-72	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	130-136
33235905-3	2020	We provide a molecular explanation: the deoxyribonucleoside triphosphate (dNTP) hydrolase SAM and HD domain-containing protein 1 (SAMHD1) prevents the accumulation of toxic dNTP levels during purine nucleoside phosphorylase inhibition.	Parathion	74-78	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	90-128
33235905-3	2020	We provide a molecular explanation: the deoxyribonucleoside triphosphate (dNTP) hydrolase SAM and HD domain-containing protein 1 (SAMHD1) prevents the accumulation of toxic dNTP levels during purine nucleoside phosphorylase inhibition.	Parathion	74-78	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	130-136
33235905-3	2020	We provide a molecular explanation: the deoxyribonucleoside triphosphate (dNTP) hydrolase SAM and HD domain-containing protein 1 (SAMHD1) prevents the accumulation of toxic dNTP levels during purine nucleoside phosphorylase inhibition.	Parathion	173-177	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	90-128
33235905-3	2020	We provide a molecular explanation: the deoxyribonucleoside triphosphate (dNTP) hydrolase SAM and HD domain-containing protein 1 (SAMHD1) prevents the accumulation of toxic dNTP levels during purine nucleoside phosphorylase inhibition.	Parathion	173-177	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	130-136
34893529-1	2022	SAMHD1 is a potent HIV-1 restriction factor that blocks reverse transcription in monocytes, dendritic cells and resting CD4+ T cells by decreasing intracellular dNTP pools.	Parathion	161-165	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
34976810-3	2021	SAMHD1 was also reported as a barrier to cytarabine, a common chemotherapy drug for mantle cell lymphoma (MCL), and as a biomarker of grim prognosis for acute myelocytic leukemia (AML) patients.	Cytarabine	41-51	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
34976810-11	2021	The MCL cell line with SAMHD1 knockdown showed lower Ki-67 proliferation index, higher caspase-3, and higher sensitivity to cytarabine.	Cytarabine	124-134	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	23-29
34738194-7	2022	We hypothesized that expression of SAMHD1 could predict short time to progression in patients treated with Cytarabine as part of high-dose chemotherapy.	Cytarabine	107-117	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	35-41
34641952-1	2021	BACKGROUND: SAMHD1 mediates resistance to anti-cancer nucleoside analogues, including cytarabine, decitabine, and nelarabine that are commonly used for the treatment of leukaemia, through cleavage of their triphosphorylated forms.	Nucleosides	54-64	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	12-18
34697376-4	2021	Vpx in SIVmac can induce proteosomal degradation of SAMHD1, which then leads to a decrease in the cytoplasmic dNTP pool.	Parathion	110-114	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	52-58
34492683-7	2021	Interestingly, IKZF1 knockout and IK6 knock-in cells both have significantly increased sensitivity to cytarabine, likely owing to marked downregulation of SAMHD1 after IKZF1 knockout.	Cytarabine	102-112	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	155-161
34641952-1	2021	BACKGROUND: SAMHD1 mediates resistance to anti-cancer nucleoside analogues, including cytarabine, decitabine, and nelarabine that are commonly used for the treatment of leukaemia, through cleavage of their triphosphorylated forms.	Cytarabine	86-96	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	12-18
34641952-1	2021	BACKGROUND: SAMHD1 mediates resistance to anti-cancer nucleoside analogues, including cytarabine, decitabine, and nelarabine that are commonly used for the treatment of leukaemia, through cleavage of their triphosphorylated forms.	Decitabine	98-108	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	12-18
34641952-1	2021	BACKGROUND: SAMHD1 mediates resistance to anti-cancer nucleoside analogues, including cytarabine, decitabine, and nelarabine that are commonly used for the treatment of leukaemia, through cleavage of their triphosphorylated forms.	nelarabine	114-124	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	12-18
34641952-2	2021	Hence, SAMHD1 inhibitors are promising candidates for the sensitisation of leukaemia cells to nucleoside analogue-based therapy.	Nucleosides	94-104	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	7-13
34641952-3	2021	Here, we investigated the effects of the cytosine analogue CNDAC, which has been proposed to be a SAMHD1 inhibitor, in the context of SAMHD1.	2'-cyano-2'-deoxyarabinofuranosylcytosine	59-64	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	98-104
34641952-11	2021	RESULTS: Although the cytosine analogue CNDAC was anticipated to inhibit SAMHD1, SAMHD1 mediated intrinsic CNDAC resistance in leukaemia cells.	Cytosine	22-30	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	73-79
34641952-11	2021	RESULTS: Although the cytosine analogue CNDAC was anticipated to inhibit SAMHD1, SAMHD1 mediated intrinsic CNDAC resistance in leukaemia cells.	Cytosine	22-30	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	81-87
34641952-11	2021	RESULTS: Although the cytosine analogue CNDAC was anticipated to inhibit SAMHD1, SAMHD1 mediated intrinsic CNDAC resistance in leukaemia cells.	2'-cyano-2'-deoxyarabinofuranosylcytosine	40-45	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	73-79
34641952-11	2021	RESULTS: Although the cytosine analogue CNDAC was anticipated to inhibit SAMHD1, SAMHD1 mediated intrinsic CNDAC resistance in leukaemia cells.	2'-cyano-2'-deoxyarabinofuranosylcytosine	40-45	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	81-87
34641952-12	2021	Accordingly, SAMHD1 depletion increased CNDAC triphosphate (CNDAC-TP) levels and CNDAC toxicity.	cndac triphosphate	40-58	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	13-19
34641952-12	2021	Accordingly, SAMHD1 depletion increased CNDAC triphosphate (CNDAC-TP) levels and CNDAC toxicity.	cndac-tp	60-68	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	13-19
34641952-12	2021	Accordingly, SAMHD1 depletion increased CNDAC triphosphate (CNDAC-TP) levels and CNDAC toxicity.	2'-cyano-2'-deoxyarabinofuranosylcytosine	81-86	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	13-19
34641952-13	2021	Enzymatic assays and crystallisation studies confirmed CNDAC-TP to be a SAMHD1 substrate.	cndac-tp	55-63	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	72-78
34641952-17	2021	In cytarabine-adapted AML cells, increased SAMHD1 and reduced DCK levels contributed to cytarabine and CNDAC resistance.	Cytarabine	3-13	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	43-49
34641952-17	2021	In cytarabine-adapted AML cells, increased SAMHD1 and reduced DCK levels contributed to cytarabine and CNDAC resistance.	Cytarabine	88-98	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	43-49
34641952-17	2021	In cytarabine-adapted AML cells, increased SAMHD1 and reduced DCK levels contributed to cytarabine and CNDAC resistance.	2'-cyano-2'-deoxyarabinofuranosylcytosine	103-108	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	43-49
34492268-6	2021	The R366C/H mutants failed to reduce intracellular dNTP levels and restrict HIV-1 replication, functions of SAMHD1 that are dependent on the ability of the enzyme to hydrolyze dNTPs.	Parathion	51-55	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	108-114
34492268-6	2021	The R366C/H mutants failed to reduce intracellular dNTP levels and restrict HIV-1 replication, functions of SAMHD1 that are dependent on the ability of the enzyme to hydrolyze dNTPs.	dntps	176-181	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	108-114
34492268-8	2021	Finally, SAMHD1 degradation in human primary activated/dividing CD4+ T cells further elevates cellular dNTP levels.	Parathion	103-107	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	9-15
34480199-1	2022	Human sterile alpha motif and HD domain-containing protein 1 (SAMHD1), originally described as the major cellular deoxyribonucleoside triphosphate triphosphohydrolase (dNTPase) balancing the intracellular deoxynucleotide (dNTP) pool, has come recently into focus of cancer research.	deoxynucleotide	205-220	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	62-68
34480199-1	2022	Human sterile alpha motif and HD domain-containing protein 1 (SAMHD1), originally described as the major cellular deoxyribonucleoside triphosphate triphosphohydrolase (dNTPase) balancing the intracellular deoxynucleotide (dNTP) pool, has come recently into focus of cancer research.	Parathion	222-226	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	62-68
34321470-0	2021	SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells.	Lysine	25-31	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	15-21
34513928-6	2021	This nuclear localization protects SAMHD1 from oxidation by cytoplasmic reactive oxygen species.	Reactive Oxygen Species	72-95	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	35-41
34321470-1	2021	SAMHD1 is a cellular triphosphohydrolase (dNTPase) proposed to inhibit HIV-1 reverse transcription in non-cycling immune cells by limiting the supply of the dNTP substrates.	Parathion	157-161	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
34321470-3	2021	Here, we show that SAMHD1 is SUMOylated on residue K595, a modification that relies on the presence of a proximal SUMO-interacting motif (SIM).	taem	51-55	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	19-25
33907561-1	2021	Human sterile alpha motif and HD-domain-containing protein 1 (SAMHD1) has been identified as a GTP or dGTP-dependent deoxynucleotide triphosphohydrolase (dNTPase) and acts as an antiviral factor against certain retroviruses and DNA viruses.	deoxyguanosine triphosphate	102-106	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	62-68
34238351-6	2021	We identified three lysine residues (K469, K595 and K622) located on the surface of SAMHD1 as the major SUMOylation sites.	Lysine	20-26	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	84-90
35085552-8	2022	Furthermore, SARS-CoV-2 replication was significantly increased in both SAMHD1 WT and KO cells when expression and phosphorylation of STAT1 were downregulated by Jak inhibitor baricitinib, which overrode the activated antiviral innate immunity in the KO cells.	baricitinib	176-187	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	72-78
35158911-1	2022	SAMHD1 is a deoxynucleotide triphosphate (dNTP) triphosphohydrolase with important roles in the control of cell proliferation and apoptosis, either through the regulation of intracellular dNTPs levels or the modulation of the DNA damage response.	triphosphoric acid	28-40	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
35158911-1	2022	SAMHD1 is a deoxynucleotide triphosphate (dNTP) triphosphohydrolase with important roles in the control of cell proliferation and apoptosis, either through the regulation of intracellular dNTPs levels or the modulation of the DNA damage response.	Parathion	42-46	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
35158911-1	2022	SAMHD1 is a deoxynucleotide triphosphate (dNTP) triphosphohydrolase with important roles in the control of cell proliferation and apoptosis, either through the regulation of intracellular dNTPs levels or the modulation of the DNA damage response.	dntps	188-193	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
35158911-7	2022	In vitro treatment with platinum-derived drugs significantly enhanced gamma-H2AX and apoptotic markers expression in knock-out cells, indicating a synergic effect of SAMHD1 depletion and platinum-based treatment.	Platinum	24-32	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	166-172
35023831-7	2022	Rare variant analysis identified SAMHD1 mutation carriers as having higher mtDNA-CN (beta=0.23 SDs; 95% CI, 0.18- 0.29; P=2.6x10-19), a potential therapeutic target for patients with mtDNA depletion disorders, but at increased risk of breast cancer (OR=1.91; 95% CI, 1.52-2.40; P=2.7x10-8).	Sodium Dodecyl Sulfate	95-98	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	33-39
33988981-0	2021	Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of Rp- and Sp-dNTPalphaS Diastereomers.	rp- and sp-dntpalphas	94-115	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	50-56
33988981-1	2021	SAMHD1 is a fundamental regulator of cellular dNTPs that catalyzes their hydrolysis into 2"-deoxynucleoside and triphosphate, restricting the replication of viruses, including HIV-1, in CD4+ myeloid lineage and resting T-cells.	dntps	46-51	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
33988981-1	2021	SAMHD1 is a fundamental regulator of cellular dNTPs that catalyzes their hydrolysis into 2"-deoxynucleoside and triphosphate, restricting the replication of viruses, including HIV-1, in CD4+ myeloid lineage and resting T-cells.	2"-deoxynucleoside	89-107	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
33988981-1	2021	SAMHD1 is a fundamental regulator of cellular dNTPs that catalyzes their hydrolysis into 2"-deoxynucleoside and triphosphate, restricting the replication of viruses, including HIV-1, in CD4+ myeloid lineage and resting T-cells.	triphosphoric acid	112-124	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
33988981-4	2021	Here, we probe dNTP hydrolysis and inhibition of SAMHD1 using the Rp and Sp diastereomers of dNTPalphaS nucleotides.	dntpalphas nucleotides	93-115	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	49-55
33988981-5	2021	Our biochemical and enzymological data show that the alpha-phosphorothioate substitution in Sp-dNTPalphaS but not Rp-dNTPalphaS diastereomers prevents Mg2+ ion coordination at both the allosteric and catalytic sites, rendering SAMHD1 unable to form stable, catalytically active homotetramers or hydrolyze substrate dNTPs at the catalytic site.	alpha-phosphorothioate	53-75	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	227-233
33988981-5	2021	Our biochemical and enzymological data show that the alpha-phosphorothioate substitution in Sp-dNTPalphaS but not Rp-dNTPalphaS diastereomers prevents Mg2+ ion coordination at both the allosteric and catalytic sites, rendering SAMHD1 unable to form stable, catalytically active homotetramers or hydrolyze substrate dNTPs at the catalytic site.	sp-dntpalphas	92-105	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	227-233
33988981-5	2021	Our biochemical and enzymological data show that the alpha-phosphorothioate substitution in Sp-dNTPalphaS but not Rp-dNTPalphaS diastereomers prevents Mg2+ ion coordination at both the allosteric and catalytic sites, rendering SAMHD1 unable to form stable, catalytically active homotetramers or hydrolyze substrate dNTPs at the catalytic site.	magnesium ion	151-155	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	227-233
33988981-7	2021	For the first time, we present a cocrystal structure of SAMHD1 with a substrate, Rp-dGTPalphaS, in which an Fe-Mg-bridging water species is poised for nucleophilic attack on the Palpha.	rp-dgtpalphas	81-94	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	56-62
33988981-7	2021	For the first time, we present a cocrystal structure of SAMHD1 with a substrate, Rp-dGTPalphaS, in which an Fe-Mg-bridging water species is poised for nucleophilic attack on the Palpha.	Iron	108-110	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	56-62
33988981-7	2021	For the first time, we present a cocrystal structure of SAMHD1 with a substrate, Rp-dGTPalphaS, in which an Fe-Mg-bridging water species is poised for nucleophilic attack on the Palpha.	Water	123-128	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	56-62
33988981-9	2021	On the basis of these data, we present a model for SAMHD1 stereospecific hydrolysis of Rp-dNTPalphaS nucleotides and for a mode of competitive inhibition by Sp-dNTPalphaS nucleotides that competes with formation of the enzyme-substrate complex.	rp-dntpalphas nucleotides	87-112	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	51-57
33988981-9	2021	On the basis of these data, we present a model for SAMHD1 stereospecific hydrolysis of Rp-dNTPalphaS nucleotides and for a mode of competitive inhibition by Sp-dNTPalphaS nucleotides that competes with formation of the enzyme-substrate complex.	sp-dntpalphas nucleotides	157-182	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	51-57
35439288-8	2022	Further aggravating dNTP imbalance by depleting the dNTP hydrolase SAM domain and HD domain-containing protein 1 (SAMHD1) enhances ablation of leukemia stem cells by RRM2 hyperactivation.	Parathion	20-24	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	67-112
35439288-8	2022	Further aggravating dNTP imbalance by depleting the dNTP hydrolase SAM domain and HD domain-containing protein 1 (SAMHD1) enhances ablation of leukemia stem cells by RRM2 hyperactivation.	Parathion	20-24	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	114-120
35439288-8	2022	Further aggravating dNTP imbalance by depleting the dNTP hydrolase SAM domain and HD domain-containing protein 1 (SAMHD1) enhances ablation of leukemia stem cells by RRM2 hyperactivation.	Parathion	52-56	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	67-112
35439288-8	2022	Further aggravating dNTP imbalance by depleting the dNTP hydrolase SAM domain and HD domain-containing protein 1 (SAMHD1) enhances ablation of leukemia stem cells by RRM2 hyperactivation.	Parathion	52-56	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	114-120
33907561-2	2021	Genetic mutation in SAMHD1 causes the inflammatory Aicardi-Goutieres Syndrome and abnormal intracellular deoxyribonucleoside triphosphates (dNTPs) pool.	deoxyribonucleoside triphosphates	105-138	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	20-26
33907561-2	2021	Genetic mutation in SAMHD1 causes the inflammatory Aicardi-Goutieres Syndrome and abnormal intracellular deoxyribonucleoside triphosphates (dNTPs) pool.	dntps	140-145	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	20-26
33391506-0	2021	Hexosamine biosynthetic pathway promotes the antiviral activity of SAMHD1 by enhancing O-GlcNAc transferase-mediated protein O-GlcNAcylation.	Hexosamines	0-10	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	67-73
33979727-0	2021	SAMHD1 mutations in mantle cell lymphoma are recurrent and confer in vitro resistance to nucleoside analogues.	Nucleosides	89-99	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
33417760-0	2021	A Mitochondrial Orthologue of the dNTP Triphosphohydrolase SAMHD1 Is Essential and Controls Pyrimidine Homeostasis in Trypanosoma brucei.	pyrimidine	92-102	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	59-65
33417760-3	2021	In this respect, the sterile alpha motif and histidine-aspartate domain-containing protein 1 (SAMHD1) appears to be the most relevant dNTPase controlling dNTP/deoxynucleoside homeostasis in mammalian cells.	Parathion	134-138	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	94-100
33417760-3	2021	In this respect, the sterile alpha motif and histidine-aspartate domain-containing protein 1 (SAMHD1) appears to be the most relevant dNTPase controlling dNTP/deoxynucleoside homeostasis in mammalian cells.	deoxynucleoside	159-174	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	94-100
33417760-4	2021	Here, we have characterized the role of a unique trypanosomal SAMHD1 orthologue denominated TbHD52.	tbhd52	92-98	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	62-68
33177202-1	2021	Sterile alpha motif and HD-domain-containing protein 1 (SAMHD1) restricts HIV-1 replication by limiting the intracellular dNTP pool.	Parathion	122-126	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	56-62
33531504-0	2021	Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification.	gpsn	97-101	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	24-30
33531504-1	2021	SAMHD1 impedes infection of myeloid cells and resting T lymphocytes by retroviruses, and the enzymatic activity of the protein-dephosphorylation of deoxynucleotide triphosphates (dNTPs)-implicates enzymatic dNTP depletion in innate antiviral immunity.	deoxynucleotide triphosphates	148-177	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
33531504-1	2021	SAMHD1 impedes infection of myeloid cells and resting T lymphocytes by retroviruses, and the enzymatic activity of the protein-dephosphorylation of deoxynucleotide triphosphates (dNTPs)-implicates enzymatic dNTP depletion in innate antiviral immunity.	dntps	179-184	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
33531504-1	2021	SAMHD1 impedes infection of myeloid cells and resting T lymphocytes by retroviruses, and the enzymatic activity of the protein-dephosphorylation of deoxynucleotide triphosphates (dNTPs)-implicates enzymatic dNTP depletion in innate antiviral immunity.	Parathion	179-183	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
33531504-6	2021	The findings link nucleic acid binding to the antiretroviral activity of SAMHD1, shed light on the immunomodulatory effects of synthetic phosphorothioated oligonucleotides and raise questions about the role of nucleic acid phosphorothioation in human innate immunity.	phosphorothioated oligonucleotides	137-171	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	73-79
32638373-1	2021	The sterile alpha motif and histidine-aspartic domain-containing protein 1 (SAMHD1) has been demonstrated to predict the response to high-dose cytarabine consolidation treatment in acute myeloid leukemia patients.	Cytarabine	143-153	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	76-82
32638373-2	2021	Here, we evaluated SAMHD1 as potential biomarker for the response to high-dose cytarabine in mantle cell lymphoma (MCL) patients.	Cytarabine	79-89	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	19-25
32638373-6	2021	In patients treated with high-dose cytarabine- or fludarabine-containing regimes, SAMHD1 expression was not significantly associated with FFS or complete remission rate.	Cytarabine	35-45	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	82-88
32638373-6	2021	In patients treated with high-dose cytarabine- or fludarabine-containing regimes, SAMHD1 expression was not significantly associated with FFS or complete remission rate.	fludarabine	50-61	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	82-88
32638373-7	2021	SAMHD1 expression in B cell lymphoma cell lines, however, inversely correlated with their in vitro response to cytarabine as single agent (R = 0.65, p = 0.0065).	Cytarabine	111-121	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
33391506-12	2021	The findings reveal a link between HBP, O-GlcNAc modification, and innate antiviral immunity by targeting SAMHD1.	o-glcnac	40-48	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	106-112
33008888-3	2020	We previously reported that SAMHD1 non-counteracting lentiviruses may have evolved to harbor reverse transcriptase (RT) proteins that efficiently polymerize DNA, even at low dNTP concentrations, to circumvent SAMHD1 restriction.	Parathion	174-178	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	28-34
33135886-1	2020	The sterile alpha motif and histidine-aspartate domain-containing protein 1 (or SAMHD1) is a human protein that restricts HIV-1 in select terminally differentiated cells of the immune system by acting as a triphosphohydrolase, lowering dNTP pools.	Parathion	236-240	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	80-86
33135886-4	2020	We have found that dimeric-GTP bound SAMHD1 can exist as a viable meso-stable hold state with extensive motion in the C-terminal domain, which is quenched upon tetramer assembly.	Guanosine Triphosphate	27-30	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	37-43
33135886-7	2020	In sum, our results suggest a model wherein dimeric SAMHD1 exists as a "hold state" in the cytosol, ready to be activated by dATP concentrations, where the "tunability" of this activation is further regulated by the redox state of the enzyme.	2'-deoxyadenosine triphosphate	125-129	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	52-58
33008888-1	2020	This is because high expression levels of the active host deoxynucleotide triphosphohydrolase  sterile alpha motif  domain and histidine-aspartate  domain-containing protein 1 (SAMHD1) depletes intracellular dNTPs, which restricts HIV-1 reverse transcription, and results in a restrictive infection in this myeloid cell type.	dntps	208-213	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	177-183
32468062-1	2020	Sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1) can inhibit reverse transcription of human immunodeficiency virus-1 (HIV-1) by hydrolyzing intracellular deoxy-ribonucleoside triphosphate.	deoxy-ribonucleoside triphosphate	190-223	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	77-83
33008888-2	2020	Some SIVs overcome SAMHD1 restriction using viral protein X (Vpx), a viral accessory protein that induces proteasomal degradation of SAMHD1, increasing cellular dNTP concentrations and enabling efficient proviral DNA synthesis.	Parathion	161-165	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	19-25
32511795-0	2020	SAMHD1-mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination.	Parathion	16-20	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
32511795-1	2020	Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1), a dNTP triphosphohydrolase, regulates the levels of cellular dNTPs through their hydrolysis.	Parathion	88-92	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	77-83
32511795-1	2020	Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1), a dNTP triphosphohydrolase, regulates the levels of cellular dNTPs through their hydrolysis.	dntps	147-152	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	77-83
32511795-2	2020	SAMHD1 protects cells from invading viruses that depend on dNTPs to replicate and is frequently mutated in cancers and Aicardi-Goutieres syndrome, a hereditary autoimmune encephalopathy.	dntps	59-64	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
32511795-8	2020	We propose that SAMHD1-mediated dNTP balance regulates dNTP-sensitive DNA end-processing enzyme and promotes CSR and aberrant genomic rearrangements by suppressing the insertional DNA repair pathway.	Parathion	32-36	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	16-22
32511795-8	2020	We propose that SAMHD1-mediated dNTP balance regulates dNTP-sensitive DNA end-processing enzyme and promotes CSR and aberrant genomic rearrangements by suppressing the insertional DNA repair pathway.	Parathion	55-59	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	16-22
32986788-1	2020	SAMHD1 is a host restriction factor that functions to restrict both retroviruses and DNA viruses, based on its nuclear deoxynucleotide triphosphate (dNTP) hydrolase activity that limits availability of intracellular dNTP pools.	deoxynucleotide triphosphate	119-147	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
32986788-1	2020	SAMHD1 is a host restriction factor that functions to restrict both retroviruses and DNA viruses, based on its nuclear deoxynucleotide triphosphate (dNTP) hydrolase activity that limits availability of intracellular dNTP pools.	Parathion	149-153	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
32986788-1	2020	SAMHD1 is a host restriction factor that functions to restrict both retroviruses and DNA viruses, based on its nuclear deoxynucleotide triphosphate (dNTP) hydrolase activity that limits availability of intracellular dNTP pools.	Parathion	216-220	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
32581304-0	2020	SAMHD1 is a key regulator of the lineage-specific response of acute lymphoblastic leukaemias to nelarabine.	nelarabine	96-106	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
32751972-6	2020	Macrophages are an important target for HIV-1 but express high levels of the deoxynucleotide-triphosphate hydrolase SAMHD1, which restricts viral DNA synthesis by decreasing levels of dNTPs.	dntps	184-189	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	116-122
32850489-1	2020	Sterile alpha motif (SAM) and histidine-aspartate (HD) domain-containing protein 1 (SAMHD1) acts as a restriction factor for several RNA and DNA viruses by limiting the intracellular pool of deoxynucleoside triphosphates.	deoxynucleoside triphosphates	191-220	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	84-90
32850489-6	2020	This reduction of SAMHD1 was effectively blocked by MLN4924, an inhibitor of the Cullin-RING-E3 ligase (CRL) complexes, but not by bafilomycin A1, an inhibitor of vacuolar-type H+-ATPase.	pevonedistat	52-59	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	18-24
32581304-3	2020	Here, data from pharmacogenomics studies and a panel of ALL cell lines reveal an inverse correlation between nelarabine sensitivity and the expression of SAMHD1, which can hydrolyse and inactivate triphosphorylated nucleoside analogues.	nelarabine	109-119	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	154-160
32581304-3	2020	Here, data from pharmacogenomics studies and a panel of ALL cell lines reveal an inverse correlation between nelarabine sensitivity and the expression of SAMHD1, which can hydrolyse and inactivate triphosphorylated nucleoside analogues.	Nucleosides	215-225	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	154-160
32581304-6	2020	SAMHD1 depletion sensitises B-ALL cells to AraG, while ectopic SAMHD1 expression in SAMHD1-null T-ALL cells induces AraG resistance.	9-arabinofuranosylguanine	43-47	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
32581304-6	2020	SAMHD1 depletion sensitises B-ALL cells to AraG, while ectopic SAMHD1 expression in SAMHD1-null T-ALL cells induces AraG resistance.	9-arabinofuranosylguanine	116-120	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	63-69
32581304-6	2020	SAMHD1 depletion sensitises B-ALL cells to AraG, while ectopic SAMHD1 expression in SAMHD1-null T-ALL cells induces AraG resistance.	9-arabinofuranosylguanine	116-120	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	63-69
32581304-7	2020	SAMHD1 has a larger impact on nelarabine/AraG than on cytarabine in ALL cells.	nelarabine	30-40	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
32581304-7	2020	SAMHD1 has a larger impact on nelarabine/AraG than on cytarabine in ALL cells.	9-arabinofuranosylguanine	41-45	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
32581304-7	2020	SAMHD1 has a larger impact on nelarabine/AraG than on cytarabine in ALL cells.	Cytarabine	54-64	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
32581304-9	2020	In conclusion, SAMHD1 promoter methylation and, in turn, SAMHD1 expression levels determine ALL cell response to nelarabine.	nelarabine	113-123	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	15-21
32581304-9	2020	In conclusion, SAMHD1 promoter methylation and, in turn, SAMHD1 expression levels determine ALL cell response to nelarabine.	nelarabine	113-123	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	57-63
32402273-0	2020	SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP.	forodesine	30-40	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
32576829-0	2020	Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.	Water	73-78	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	22-28
32576829-0	2020	Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.	Parathion	88-92	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	22-28
32576829-1	2020	SAMHD1 regulates cellular 2"-deoxynucleoside-5"-triphosphate (dNTP) homeostasis by catalysing the hydrolysis of dNTPs into 2"-deoxynucleosides and triphosphate.	2"-deoxynucleoside-5"-triphosphate	26-60	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
32576829-1	2020	SAMHD1 regulates cellular 2"-deoxynucleoside-5"-triphosphate (dNTP) homeostasis by catalysing the hydrolysis of dNTPs into 2"-deoxynucleosides and triphosphate.	Parathion	62-66	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
32576829-1	2020	SAMHD1 regulates cellular 2"-deoxynucleoside-5"-triphosphate (dNTP) homeostasis by catalysing the hydrolysis of dNTPs into 2"-deoxynucleosides and triphosphate.	dntps	112-117	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
32576829-1	2020	SAMHD1 regulates cellular 2"-deoxynucleoside-5"-triphosphate (dNTP) homeostasis by catalysing the hydrolysis of dNTPs into 2"-deoxynucleosides and triphosphate.	2"-deoxynucleosides	123-142	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
32576829-1	2020	SAMHD1 regulates cellular 2"-deoxynucleoside-5"-triphosphate (dNTP) homeostasis by catalysing the hydrolysis of dNTPs into 2"-deoxynucleosides and triphosphate.	triphosphoric acid	48-60	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
32576829-2	2020	In CD4+ myeloid lineage and resting T-cells, SAMHD1 blocks HIV-1 and other viral infections by depletion of the dNTP pool to a level that cannot support replication.	Parathion	112-116	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	45-51
32576829-4	2020	Furthermore, SAMHD1 sensitises cancer cells to nucleoside-analogue anti-cancer therapies and is linked with DNA repair and suppression of the interferon response to cytosolic nucleic acids.	Nucleosides	47-57	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	13-19
32576829-5	2020	Nevertheless, despite its requirement in these processes, the fundamental mechanism of SAMHD1-catalysed dNTP hydrolysis remained unknown.	Parathion	104-108	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	87-93
32576829-6	2020	Here, we present structural and enzymological data showing that SAMHD1 utilises an active site, bi-metallic iron-magnesium centre that positions a hydroxide nucleophile in-line with the Palpha-O5" bond to catalyse phosphoester bond hydrolysis.	Iron	108-112	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	64-70
32576829-6	2020	Here, we present structural and enzymological data showing that SAMHD1 utilises an active site, bi-metallic iron-magnesium centre that positions a hydroxide nucleophile in-line with the Palpha-O5" bond to catalyse phosphoester bond hydrolysis.	Magnesium	113-122	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	64-70
32576829-6	2020	Here, we present structural and enzymological data showing that SAMHD1 utilises an active site, bi-metallic iron-magnesium centre that positions a hydroxide nucleophile in-line with the Palpha-O5" bond to catalyse phosphoester bond hydrolysis.	hydroxide ion	147-156	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	64-70
32576829-7	2020	This precise molecular mechanism for SAMHD1 catalysis, reveals how SAMHD1 down-regulates cellular dNTP and modulates the efficacy of nucleoside-based anti-cancer and anti-viral therapies.	Parathion	98-102	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	37-43
32576829-7	2020	This precise molecular mechanism for SAMHD1 catalysis, reveals how SAMHD1 down-regulates cellular dNTP and modulates the efficacy of nucleoside-based anti-cancer and anti-viral therapies.	Parathion	98-102	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	67-73
32576829-7	2020	This precise molecular mechanism for SAMHD1 catalysis, reveals how SAMHD1 down-regulates cellular dNTP and modulates the efficacy of nucleoside-based anti-cancer and anti-viral therapies.	Nucleosides	133-143	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	37-43
32576829-7	2020	This precise molecular mechanism for SAMHD1 catalysis, reveals how SAMHD1 down-regulates cellular dNTP and modulates the efficacy of nucleoside-based anti-cancer and anti-viral therapies.	Nucleosides	133-143	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	67-73
32402273-0	2020	SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP.	deoxyguanosine triphosphate	101-105	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
32402273-2	2020	We report that SAMHD1, a phosphohydrolase degrading deoxyribonucleoside triphosphate (dNTP), protects cells against the effects of dNTP imbalances.	deoxyribonucleoside triphosphate	52-84	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	15-21
32402273-2	2020	We report that SAMHD1, a phosphohydrolase degrading deoxyribonucleoside triphosphate (dNTP), protects cells against the effects of dNTP imbalances.	Parathion	86-90	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	15-21
32402273-2	2020	We report that SAMHD1, a phosphohydrolase degrading deoxyribonucleoside triphosphate (dNTP), protects cells against the effects of dNTP imbalances.	Parathion	131-135	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	15-21
32402273-3	2020	SAMHD1-deficient cells induce intrinsic apoptosis upon provision of deoxyribonucleosides, particularly deoxyguanosine (dG).	Deoxyribonucleosides	68-88	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
32402273-3	2020	SAMHD1-deficient cells induce intrinsic apoptosis upon provision of deoxyribonucleosides, particularly deoxyguanosine (dG).	Deoxyguanosine	103-117	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
32402273-4	2020	Moreover, dG and forodesine act synergistically to kill cells lacking SAMHD1.	forodesine	17-27	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	70-76
32402273-7	2020	We therefore propose to use forodesine as a precision medicine for leukemia, stratifying patients by SAMHD1 genotype or expression.	forodesine	28-38	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	101-107
32319570-0	2020	Involvement of SAMHD1 in dNTP homeostasis and the maintenance of genomic integrity and oncotherapy (Review).	Parathion	25-29	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	15-21
32319570-1	2020	Sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1), the only deoxynucleotide triphosphate (dNTP) hydrolase in eukaryotes, plays a crucial role in regulating the dynamic balance and ratio of cellular dNTP pools.	deoxynucleotide triphosphate	95-123	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	77-83
32319570-1	2020	Sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1), the only deoxynucleotide triphosphate (dNTP) hydrolase in eukaryotes, plays a crucial role in regulating the dynamic balance and ratio of cellular dNTP pools.	Parathion	125-129	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	77-83
32319570-1	2020	Sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1), the only deoxynucleotide triphosphate (dNTP) hydrolase in eukaryotes, plays a crucial role in regulating the dynamic balance and ratio of cellular dNTP pools.	Parathion	233-237	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	77-83
32319570-3	2020	Homozygous SAMHD1 mutations have been identified in immune system disorders, such as autoimmune disease Aicardi-Goutieres syndrome (AGS), whose primary pathogenesis is associated with the abnormal accumulation and disproportion of dNTPs.	dntps	231-236	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	11-17
32319570-6	2020	The present review summarizes the molecular mechanisms of SAMHD1 regarding the regulation of dNTP homeostasis and DNA damage response.	Parathion	93-97	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	58-64
32244340-3	2020	When active, dNTP triphosphohydrolase activity of SAMHD1 degrades dNTPs into their 2"-deoxynucleoside (dN) and triphosphate subparts, steadily depleting intercellular dNTP pools.	triphosphoric acid	111-123	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	50-56
32244340-3	2020	When active, dNTP triphosphohydrolase activity of SAMHD1 degrades dNTPs into their 2"-deoxynucleoside (dN) and triphosphate subparts, steadily depleting intercellular dNTP pools.	dn	13-15	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	50-56
32244340-3	2020	When active, dNTP triphosphohydrolase activity of SAMHD1 degrades dNTPs into their 2"-deoxynucleoside (dN) and triphosphate subparts, steadily depleting intercellular dNTP pools.	Parathion	66-70	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	50-56
32244340-2	2020	While the process of dNTP biosynthesis by cellular enzymes, such as ribonucleotide reductase (RNR) and thymidine kinase (TK), has been extensively investigated, a negative regulatory mechanism of dNTP pools was recently found to involve sterile alpha motif (SAM) domain and histidine-aspartate (HD) domain-containing protein 1, SAMHD1.	Parathion	21-25	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	328-334
32244340-2	2020	While the process of dNTP biosynthesis by cellular enzymes, such as ribonucleotide reductase (RNR) and thymidine kinase (TK), has been extensively investigated, a negative regulatory mechanism of dNTP pools was recently found to involve sterile alpha motif (SAM) domain and histidine-aspartate (HD) domain-containing protein 1, SAMHD1.	Parathion	196-200	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	328-334
32244340-4	2020	The differential expression levels and activation states of SAMHD1 in various cell types contributes to unique dNTP pools that either aid (i.e., dividing T cells) or restrict (i.e., nondividing macrophages) viral replication that consumes cellular dNTPs.	Parathion	111-115	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	60-66
32244340-3	2020	When active, dNTP triphosphohydrolase activity of SAMHD1 degrades dNTPs into their 2"-deoxynucleoside (dN) and triphosphate subparts, steadily depleting intercellular dNTP pools.	Parathion	13-17	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	50-56
32244340-3	2020	When active, dNTP triphosphohydrolase activity of SAMHD1 degrades dNTPs into their 2"-deoxynucleoside (dN) and triphosphate subparts, steadily depleting intercellular dNTP pools.	dntps	66-71	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	50-56
32244340-4	2020	The differential expression levels and activation states of SAMHD1 in various cell types contributes to unique dNTP pools that either aid (i.e., dividing T cells) or restrict (i.e., nondividing macrophages) viral replication that consumes cellular dNTPs.	dntps	248-253	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	60-66
32244340-3	2020	When active, dNTP triphosphohydrolase activity of SAMHD1 degrades dNTPs into their 2"-deoxynucleoside (dN) and triphosphate subparts, steadily depleting intercellular dNTP pools.	2"-deoxynucleoside	83-101	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	50-56
31914403-1	2020	Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) is a deoxynucleoside triphosphohydrolase (dNTPase) with a nuclear localization signal (NLS).	1-naphthyl deoxynucleoside	69-84	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-54
32197329-1	2020	Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a dNTP triphosphohydrolase involved in the regulation of the intracellular dNTP pool, linked to viral restriction, cancer development and autoimmune disorders.	Parathion	90-94	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	77-83
31914403-1	2020	Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) is a deoxynucleoside triphosphohydrolase (dNTPase) with a nuclear localization signal (NLS).	1-naphthyl deoxynucleoside	69-84	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	56-62
31442614-0	2019	Efficient pre-catalytic conformational change of reverse transcriptases from SAMHD1 non-counteracting primate lentiviruses during dNTP incorporation.	Parathion	130-134	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	77-83
31548682-4	2019	Here we investigate how HCMV achieves efficient propagation in these cells despite the SAMHD1-mediated dNTP depletion.	2,6-dimethyl-4-(2'-nitrosophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester	103-107	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	87-93
31548683-1	2019	The deoxynucleotide triphosphate (dNTP) hydrolase SAMHD1 inhibits retroviruses in non-dividing myeloid cells.	pyrene deoxynucleotide	4-32	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	50-56
31548683-1	2019	The deoxynucleotide triphosphate (dNTP) hydrolase SAMHD1 inhibits retroviruses in non-dividing myeloid cells.	pyrene deoxynucleotide	34-38	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	50-56
31548683-5	2019	The phosphorylation of SAMHD1 in infected cells correlated with a reduced level of dNTP hydrolase activity and the loss of viral restriction.	pyrene deoxynucleotide	83-87	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	23-29
31806704-4	2020	Here, we tested whether the highly abundant SAM domain- and HD domain-containing protein 1 (SAMHD1) deoxynucleoside triphosphorylase in macrophages is responsible for frequent rNTP incorporation during HIV-1 reverse transcription.	rntp	176-180	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	44-90
31806704-4	2020	Here, we tested whether the highly abundant SAM domain- and HD domain-containing protein 1 (SAMHD1) deoxynucleoside triphosphorylase in macrophages is responsible for frequent rNTP incorporation during HIV-1 reverse transcription.	rntp	176-180	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	92-98
31806704-10	2020	These findings suggest that noncanonical rNTP incorporation is regulated by SAMHD1 in macrophages, whereas rNMPs incorporated in HIV-1 proviral DNA remain unrepaired.	rntp	41-45	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	76-82
31806704-11	2020	This suggests a potential long-term DNA damage impact of SAMHD1-mediated rNTP incorporation in macrophages.	rntp	73-77	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	57-63
31750734-6	2020	On the contrary, SAMHD1 siRNA, which increases the concentration of dNTPs, increased growth of wild type, D316H, and S605del POLD1 fibroblasts.	dntps	68-73	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	17-23
31914608-1	2020	In mammalian cells, the catabolic activity of the dNTP triphosphohydrolase SAMHD1 sets the balance and concentration of the four dNTPs.	dntps	129-134	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	75-81
31914608-2	2020	Deficiency of SAMHD1 leads to unequally increased pools and marked dNTP imbalance.	Parathion	67-71	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	14-20
31914608-3	2020	Imbalanced dNTP pools increase mutation frequency in cancer cells, but it is not known if the SAMHD1-induced dNTP imbalance favors accumulation of somatic mutations in non-transformed cells.	Parathion	109-113	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	94-100
31914608-4	2020	Here, we have investigated how fibroblasts from Aicardi-Goutieres Syndrome (AGS) patients with mutated SAMHD1 react to the constitutive pool imbalance characterized by a huge dGTP pool.	deoxyguanosine triphosphate	175-179	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	103-109
31442614-1	2019	Unlike HIV-1, HIV-2 and some SIV strains replicate at high dNTP concentrations even in macrophages due to their accessory proteins, Vpx or Vpr, that target SAMHD1 dNTPase for proteasomal degradation.	Parathion	59-63	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	156-162
31442614-2	2019	We previously reported that HIV-1 reverse transcriptase (RT) efficiently synthesizes DNA even at low dNTP concentrations because HIV-1 RT displays faster pre-steady state kpol values than SAMHD1 counteracting lentiviral RTs.	Parathion	101-105	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	188-194
31442614-4	2019	Our study demonstrates that RTs of SAMHD1 non-counteracting lentiviruses have a faster conformational change rate during dNTP incorporation, supporting that these lentiviruses may have evolved to harbor RTs that can efficiently execute the conformational change step in order to circumvent SAMHD1 restriction and dNTP depletion in macrophages.	Parathion	121-125	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	35-41
31442614-4	2019	Our study demonstrates that RTs of SAMHD1 non-counteracting lentiviruses have a faster conformational change rate during dNTP incorporation, supporting that these lentiviruses may have evolved to harbor RTs that can efficiently execute the conformational change step in order to circumvent SAMHD1 restriction and dNTP depletion in macrophages.	Parathion	121-125	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	290-296
31442614-4	2019	Our study demonstrates that RTs of SAMHD1 non-counteracting lentiviruses have a faster conformational change rate during dNTP incorporation, supporting that these lentiviruses may have evolved to harbor RTs that can efficiently execute the conformational change step in order to circumvent SAMHD1 restriction and dNTP depletion in macrophages.	Parathion	313-317	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	35-41
31442614-4	2019	Our study demonstrates that RTs of SAMHD1 non-counteracting lentiviruses have a faster conformational change rate during dNTP incorporation, supporting that these lentiviruses may have evolved to harbor RTs that can efficiently execute the conformational change step in order to circumvent SAMHD1 restriction and dNTP depletion in macrophages.	Parathion	313-317	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	290-296
31296733-1	2019	Vertebrate protein SAMHD1 (sterile-alpha-motif and HD domain containing protein 1) regulates the cellular dNTP (2"-deoxynucleoside-5"-triphosphate) pool by catalysing the hydrolysis of dNTP into 2"-deoxynucleoside and triphosphate products.	Parathion	106-110	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	19-25
31462561-3	2019	The sterile alpha motif (SAM) domain and histidine-aspartate (HD) domain-containing protein 1 (SAMHD1) is a phosphohydrolase and reduces the cellular deoxynucleoside triphosphate (dNTP) concentration, which impairs poxviral DNA replication in human dendritic cells (DCs).	deoxynucleoside triphosphate	150-178	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	95-101
31462561-3	2019	The sterile alpha motif (SAM) domain and histidine-aspartate (HD) domain-containing protein 1 (SAMHD1) is a phosphohydrolase and reduces the cellular deoxynucleoside triphosphate (dNTP) concentration, which impairs poxviral DNA replication in human dendritic cells (DCs).	Parathion	180-184	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	95-101
31462561-4	2019	The human immunodeficiency virus type 2 (HIV-2) and simian immunodeficiency virus (SIV) encode an accessory protein called viral protein X (Vpx) that promotes proteasomal degradation of SAMHD1, leading to a rapid increase in cellular dNTP concentrations.	Parathion	234-238	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	186-192
31600877-2	2019	By degrading cellular dNTPs to constituent deoxynucleoside and free triphosphate, SAMHD1 limits viral DNA synthesis and prevents replication of HIV-1 and some DNA viruses such as HBV, vaccinia, and HSV-1.	dntps	22-27	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	82-88
31600877-2	2019	By degrading cellular dNTPs to constituent deoxynucleoside and free triphosphate, SAMHD1 limits viral DNA synthesis and prevents replication of HIV-1 and some DNA viruses such as HBV, vaccinia, and HSV-1.	deoxynucleoside	43-58	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	82-88
31600877-2	2019	By degrading cellular dNTPs to constituent deoxynucleoside and free triphosphate, SAMHD1 limits viral DNA synthesis and prevents replication of HIV-1 and some DNA viruses such as HBV, vaccinia, and HSV-1.	triphosphoric acid	68-80	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	82-88
31462561-8	2019	MVA-vpx can be used as a tool to study poxvirus host interaction and vector safety.IMPORTANCE SAMHD1 is a phosphohydrolase and reduces cellular dNTP concentrations, which impairs poxviral DNA replication.	Parathion	144-148	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	94-100
31462561-9	2019	The simian SIV accessory protein Vpx promotes degradation of SAMHD1, leading to increased cellular dNTP concentrations.	Parathion	99-103	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	61-67
31506864-4	2019	First, dasatinib blocks infection and potential expansion of the latent reservoir by interfering with the inactivating phosphorylation of SAMHD1.	Dasatinib	7-16	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	138-144
31296733-1	2019	Vertebrate protein SAMHD1 (sterile-alpha-motif and HD domain containing protein 1) regulates the cellular dNTP (2"-deoxynucleoside-5"-triphosphate) pool by catalysing the hydrolysis of dNTP into 2"-deoxynucleoside and triphosphate products.	2"-deoxynucleoside-5"-triphosphate	112-146	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	19-25
31296733-1	2019	Vertebrate protein SAMHD1 (sterile-alpha-motif and HD domain containing protein 1) regulates the cellular dNTP (2"-deoxynucleoside-5"-triphosphate) pool by catalysing the hydrolysis of dNTP into 2"-deoxynucleoside and triphosphate products.	Parathion	185-189	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	19-25
31296733-1	2019	Vertebrate protein SAMHD1 (sterile-alpha-motif and HD domain containing protein 1) regulates the cellular dNTP (2"-deoxynucleoside-5"-triphosphate) pool by catalysing the hydrolysis of dNTP into 2"-deoxynucleoside and triphosphate products.	2"-deoxynucleoside	112-130	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	19-25
31296733-1	2019	Vertebrate protein SAMHD1 (sterile-alpha-motif and HD domain containing protein 1) regulates the cellular dNTP (2"-deoxynucleoside-5"-triphosphate) pool by catalysing the hydrolysis of dNTP into 2"-deoxynucleoside and triphosphate products.	triphosphoric acid	134-146	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	19-25
31296733-3	2019	By limiting the supply of dNTPs for viral DNA synthesis, SAMHD1 also restricts the replication of several retroviruses, such as HIV-1, and some DNA viruses in dendritic and myeloid lineage cells and resting T-cells.	Parathion	26-31	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	57-63
31296733-8	2019	We present a comprehensive mechanism detailing the structural and protein dynamics components of the allosteric coupling between nucleotide-induced tetramerization and the catalysis of dNTP hydrolysis by SAMHD1.	Parathion	185-189	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	204-210
30879196-3	2019	SAMHD1 anti-viral activity was long believed to be solely due to its ability to deplete cellular dNTPs by enzymatic degradation.	dntps	97-102	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
31375673-3	2019	Here, we show that the bioactive metabolite decitabine triphosphate, but not azacytidine triphosphate, functions as activator and substrate of the triphosphohydrolase SAMHD1 and is subject to SAMHD1-mediated inactivation.	decitabine triphosphate	44-67	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	167-173
31375673-3	2019	Here, we show that the bioactive metabolite decitabine triphosphate, but not azacytidine triphosphate, functions as activator and substrate of the triphosphohydrolase SAMHD1 and is subject to SAMHD1-mediated inactivation.	decitabine triphosphate	44-67	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	192-198
31375673-4	2019	Retrospective immunohistochemical analysis of bone marrow specimens from AML patients at diagnosis revealed that SAMHD1 expression in leukemic cells inversely correlates with clinical response to decitabine, but not to azacytidine.	Decitabine	196-206	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	113-119
31375673-5	2019	SAMHD1 ablation increases the antileukemic activity of decitabine in AML cell lines, primary leukemic blasts, and xenograft models.	Decitabine	55-65	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
31375673-6	2019	AML cells acquire resistance to decitabine partly by SAMHD1 up-regulation.	Decitabine	32-42	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	53-59
31375673-7	2019	Together, our data suggest that SAMHD1 is a biomarker for the stratified use of hypomethylating agents in AML patients and a potential target for the treatment of decitabine-resistant leukemia.	Decitabine	163-173	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	32-38
31077767-7	2019	Midostaurin induced G2/M arrest and inhibited CDK2, preventing the phosphorylation of SAMHD1 associated to inhibition of its dNTPase activity.	midostaurin	0-11	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	86-92
31077767-8	2019	In the presence of SAMHD1, midostaurin blocked HIV-1 DNA formation and viral replication.	midostaurin	27-38	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	19-25
31077767-11	2019	Our study describes a dual effect for midostaurin in HIV-1 infection, antiviral or proviral depending on SAMHD1 activation, and highlights a role for active SAMHD1 in regulating the activity of potential HIV-1 latency reversal agents.	midostaurin	38-49	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	105-111
31017331-1	2019	HIV-1 is restricted in macrophages and certain quiescent myeloid cells due to a "Scorched Earth" dNTP starvation strategy attributed to the sterile alpha motif and HD domain protein-SAMHD1.	Parathion	97-101	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	182-188
31017331-2	2019	Active SAMHD1 tetramers are assembled by GTP-Mg+2-dNTP cross bridges and cleave the triphosphate groups of dNTPs at a K m of ~10 muM, which is consistent with dNTP concentrations in cycling cells, but far higher than the equivalent concentration in quiescent cells.	Guanosine Triphosphate	41-44	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	7-13
31017331-2	2019	Active SAMHD1 tetramers are assembled by GTP-Mg+2-dNTP cross bridges and cleave the triphosphate groups of dNTPs at a K m of ~10 muM, which is consistent with dNTP concentrations in cycling cells, but far higher than the equivalent concentration in quiescent cells.	2-dntp	48-54	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	7-13
31017331-2	2019	Active SAMHD1 tetramers are assembled by GTP-Mg+2-dNTP cross bridges and cleave the triphosphate groups of dNTPs at a K m of ~10 muM, which is consistent with dNTP concentrations in cycling cells, but far higher than the equivalent concentration in quiescent cells.	triphosphoric acid	84-96	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	7-13
31017331-2	2019	Active SAMHD1 tetramers are assembled by GTP-Mg+2-dNTP cross bridges and cleave the triphosphate groups of dNTPs at a K m of ~10 muM, which is consistent with dNTP concentrations in cycling cells, but far higher than the equivalent concentration in quiescent cells.	Parathion	107-112	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	7-13
31017331-2	2019	Active SAMHD1 tetramers are assembled by GTP-Mg+2-dNTP cross bridges and cleave the triphosphate groups of dNTPs at a K m of ~10 muM, which is consistent with dNTP concentrations in cycling cells, but far higher than the equivalent concentration in quiescent cells.	Parathion	50-54	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	7-13
31017331-3	2019	Given the substantial disparity between the dNTP concentrations required to activate SAMHD1 tetramers (~10 muM) and the dNTP concentrations in noncycling cells (~10 nM), the possibility of alternate enzymatically active forms of SAMHD1, including monomers remains open.	Parathion	44-48	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	85-91
31017331-5	2019	There have been experimental studies on the regulation of SAMHD1 by Glutathione driven redox reactions recently.	Glutathione	68-79	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	58-64
31017331-6	2019	Therefore, in this work, we have performed all-atom molecular dynamics simulations to study the dynamics of monomeric SAMHD1 constructs in the context of the three redox-susceptible Cysteine residues and compared them to monomers assembled within a tetramer.	Cysteine	182-190	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	118-124
30767852-3	2019	SAMHD1 is a triphosphohydrolase that depletes the cellular pool of dNTPs in non-cycling cells starving retroviral reverse transcription.	dntps	67-72	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
31291579-1	2019	Cellular SAMHD1 inhibits replication of many viruses by limiting intracellular deoxynucleoside triphosphate (dNTP) pools.	deoxynucleoside triphosphate	79-107	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	9-15
31291579-1	2019	Cellular SAMHD1 inhibits replication of many viruses by limiting intracellular deoxynucleoside triphosphate (dNTP) pools.	Parathion	109-113	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	9-15
30767852-6	2019	Addition of deoxynucleosides alleviated the SAMHD1-mediated restriction suggesting that SAMHD1-mediated degradation of dNTPs restricts PERV replication in these human immune cells.	deoxynucleosides	12-28	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	44-50
30767852-6	2019	Addition of deoxynucleosides alleviated the SAMHD1-mediated restriction suggesting that SAMHD1-mediated degradation of dNTPs restricts PERV replication in these human immune cells.	deoxynucleosides	12-28	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	88-94
30767852-6	2019	Addition of deoxynucleosides alleviated the SAMHD1-mediated restriction suggesting that SAMHD1-mediated degradation of dNTPs restricts PERV replication in these human immune cells.	dntps	119-124	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	44-50
30767852-6	2019	Addition of deoxynucleosides alleviated the SAMHD1-mediated restriction suggesting that SAMHD1-mediated degradation of dNTPs restricts PERV replication in these human immune cells.	dntps	119-124	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	88-94
30290238-4	2019	For example, APOBEC3G deaminates cytosines to hypermutate reverse transcribed viral DNA; IFITM3 alters membranes to inhibit virus membrane fusion; MXA/B oligomerize on viral protein complexes to inhibit virus replication; SAMHD1 decreases dNTP intracellular concentrations to prevent reverse transcription of retrovirus genomes; tetherin prevents release of budding virions from cells; Viperin catalyzes formation of a nucleoside analogue that inhibits viral RNA polymerases; and ZAP binds virus RNAs to target them for degradation.	Parathion	239-243	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	222-228
30918010-4	2019	SAMHD1 is a component of the innate immune system that regulates deoxyribonucleoside triphosphate levels required for host and viral DNA synthesis.	deoxyribonucleoside triphosphate	65-97	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
30739781-7	2019	Digitonin-based cytoplasm/nucleus fractionation tests suggested that SAMHD1 is capable of being exported from the nucleus, which was confirmed by introducing exogenous exportin Xpo1 in live cells.	Digitonin	0-9	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	69-75
30290238-4	2019	For example, APOBEC3G deaminates cytosines to hypermutate reverse transcribed viral DNA; IFITM3 alters membranes to inhibit virus membrane fusion; MXA/B oligomerize on viral protein complexes to inhibit virus replication; SAMHD1 decreases dNTP intracellular concentrations to prevent reverse transcription of retrovirus genomes; tetherin prevents release of budding virions from cells; Viperin catalyzes formation of a nucleoside analogue that inhibits viral RNA polymerases; and ZAP binds virus RNAs to target them for degradation.	Nucleosides	419-429	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	222-228
30316304-1	2018	BACKGROUND: SAM domain and HD domain containing protein 1 (SAMHD1) is a host anti-HIV-1 restriction factor known to suppress viral reverse transcription in nondividing myeloid cells by its dNTP triphosphorylase activity that depletes cellular dNTPs.	Parathion	243-248	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	59-65
30181218-3	2018	SAMHD1 enforces this restriction through its dNTP triphosphohydrolase (dNTPase) activity that depletes cellular dNTPs.	Parathion	112-117	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
30181218-4	2018	Some primate lentiviruses, such as HIV-2, SIVsm, and SIVagm, counteract SAMHD1 restriction by using their viral accessory proteins (Vpx or Vpr) that induce the proteosomal degradation of SAMHD1 and increase dNTP levels.	Parathion	207-211	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	72-78
30181218-4	2018	Some primate lentiviruses, such as HIV-2, SIVsm, and SIVagm, counteract SAMHD1 restriction by using their viral accessory proteins (Vpx or Vpr) that induce the proteosomal degradation of SAMHD1 and increase dNTP levels.	Parathion	207-211	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	187-193
30181218-8	2018	Using biochemical and various cell-based assays, we observed that SAMHD1 proteins from the non-primate host species display dGTP-dependent dNTPase activity, but that the non-primate lentiviruses fail to proteosomally degrade the SAMHD1 proteins of their hosts.	deoxyguanosine triphosphate	124-128	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	66-72
30336972-1	2019	SAMHD1 is a host triphosphohydrolase that degrades intracellular deoxynucleoside triphosphates (dNTPs) to a lower level that restricts viral DNA synthesis, and thus prevents replication of diverse viruses in nondividing cells.	deoxynucleoside triphosphates	65-94	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
30336972-1	2019	SAMHD1 is a host triphosphohydrolase that degrades intracellular deoxynucleoside triphosphates (dNTPs) to a lower level that restricts viral DNA synthesis, and thus prevents replication of diverse viruses in nondividing cells.	dntps	96-101	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
30380297-1	2018	The dNTP triphosphohydrolase SAMHD1 is a regulator of cellular dNTP pools.	Parathion	4-8	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	29-35
30305425-1	2018	SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase (dNTPase) that depletes cellular dNTPs in noncycling cells to promote genome stability and to inhibit retroviral and herpes viral replication.	Parathion	94-99	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
30305425-5	2018	We found that both the catalytic and the allosteric sites of SAMHD1 are sensitive to sugar modifications of the nucleotide analogs, with the allosteric site being significantly more restrictive.	Sugars	85-90	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	61-67
30305425-6	2018	We crystallized cladribine-TP, clofarabine-TP, fludarabine-TP, vidarabine-TP, cytarabine-TP, and gemcitabine-TP in the catalytic pocket of SAMHD1.	cladribine-tp	16-29	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	139-145
30305425-6	2018	We crystallized cladribine-TP, clofarabine-TP, fludarabine-TP, vidarabine-TP, cytarabine-TP, and gemcitabine-TP in the catalytic pocket of SAMHD1.	clofarabine-tp	31-45	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	139-145
30305425-6	2018	We crystallized cladribine-TP, clofarabine-TP, fludarabine-TP, vidarabine-TP, cytarabine-TP, and gemcitabine-TP in the catalytic pocket of SAMHD1.	fludarabine-tp	47-61	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	139-145
30305425-6	2018	We crystallized cladribine-TP, clofarabine-TP, fludarabine-TP, vidarabine-TP, cytarabine-TP, and gemcitabine-TP in the catalytic pocket of SAMHD1.	vidarabine-tp	63-76	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	139-145
30305425-6	2018	We crystallized cladribine-TP, clofarabine-TP, fludarabine-TP, vidarabine-TP, cytarabine-TP, and gemcitabine-TP in the catalytic pocket of SAMHD1.	cytarabine-tp	78-91	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	139-145
30305425-6	2018	We crystallized cladribine-TP, clofarabine-TP, fludarabine-TP, vidarabine-TP, cytarabine-TP, and gemcitabine-TP in the catalytic pocket of SAMHD1.	gemcitabine-tp	97-111	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	139-145
30305425-8	2018	Of the nucleotide analogs tested, only cladribine-TP with a deoxyribose sugar efficiently induced the catalytically active SAMHD1 tetramer.	cladribine-tp	39-52	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	123-129
30305425-8	2018	Of the nucleotide analogs tested, only cladribine-TP with a deoxyribose sugar efficiently induced the catalytically active SAMHD1 tetramer.	deoxyribose sugar	60-77	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	123-129
30341277-0	2018	Low-level expression of SAMHD1 in acute myeloid leukemia (AML) blasts correlates with improved outcome upon consolidation chemotherapy with high-dose cytarabine-based regimens.	Cytarabine	150-160	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	24-30
30341277-1	2018	Sterile alpha motif and histidine/aspartic acid domain containing protein 1 (SAMHD1) limits the efficacy of cytarabine (ara-C) used in AML by hydrolyzing its active metabolite ara-CTP and thus represents a promising therapeutic target.	Cytarabine	108-118	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	77-83
30341277-1	2018	Sterile alpha motif and histidine/aspartic acid domain containing protein 1 (SAMHD1) limits the efficacy of cytarabine (ara-C) used in AML by hydrolyzing its active metabolite ara-CTP and thus represents a promising therapeutic target.	Cytarabine	120-125	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	77-83
30341277-1	2018	Sterile alpha motif and histidine/aspartic acid domain containing protein 1 (SAMHD1) limits the efficacy of cytarabine (ara-C) used in AML by hydrolyzing its active metabolite ara-CTP and thus represents a promising therapeutic target.	Arabinofuranosylcytosine Triphosphate	176-183	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	77-83
30341277-2	2018	SAMHD1 has also been implicated in DNA damage repair that may impact DNA damage-inducing therapies such as anthracyclines, during induction therapy.	Anthracyclines	107-121	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
30341277-5	2018	A sizeable patient subset with low SAMHD1 expression (<25% of positive blasts) was identified, which was significantly associated with longer event-free (EFS) and overall (OS) survival in patients receiving high-dose cytarabine (HDAC) during consolidation.	Cytarabine	220-230	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	35-41
30104243-10	2018	Furthermore, we found that TCR stimulation upregulates phosphorylation of the threonine residue (Thr592), which is a regulatory site to control SAMHD1 activity, and phosphorylation of Thr592 is critical to control SAMHD1 activity to stabilize the expression of Foxp3 and Helios in Tregs.	Threonine	78-87	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	144-150
30257946-7	2018	Treating CD4+ T cells with Ruxolitinib, an inhibitor of JAK1 and JAK2, effectively blocked IL-15-induced SAMHD1 phosphorylation and protected CD4+ T cells from HIV infection.	ruxolitinib	27-38	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	105-111
30257946-11	2018	Time-limited interventions with JAK1 inhibitors, such as Ruxolitinib, should prevent the inactivation of the endogenous restriction factor SAMHD1 and protect this long-lived CD4+ T-memory cell population from HIV infection.	ruxolitinib	57-68	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	139-145
30104243-10	2018	Furthermore, we found that TCR stimulation upregulates phosphorylation of the threonine residue (Thr592), which is a regulatory site to control SAMHD1 activity, and phosphorylation of Thr592 is critical to control SAMHD1 activity to stabilize the expression of Foxp3 and Helios in Tregs.	Threonine	78-87	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	214-220
30044979-0	2018	Functionality of Redox-Active Cysteines Is Required for Restriction of Retroviral Replication by SAMHD1.	Cysteine	30-39	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	97-103
30044979-2	2018	Here we show that SAMHD1 is a redox-sensitive enzyme and identify three redox-active cysteines within the protein: C341, C350, and C522.	Cysteine	85-94	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	18-24
29884836-6	2018	Moreover, PP2A controls SAMHD1 pT592 level in non-cycling monocyte-derived macrophages (MDMs).	pt592	31-36	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	24-30
29764952-4	2018	Here we show that stimulation by type I, type II, and to a lesser degree, type III interferons share activation of SAMHD1 via dephosphorylation at threonine-592 as a consequence of signaling.	Threonine	147-156	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	115-121
29764952-8	2018	The viral restriction imposed via IFNs or dasatinib could be overcome through depletion of SAMHD1, indicating that their effects are exerted primarily through this pathway.	Dasatinib	42-51	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	91-97
29764952-10	2018	Furthermore, SAMHD1 activation presents a pharmacologically actionable target through which HIV-1 infection can be subverted.IMPORTANCE Our experimental results demonstrate that SAMHD1 dephosphorylation at threonine-592 represents a central mechanism of HIV-1 restriction that is common to the three known families of IFNs.	Threonine	206-215	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	13-19
29764952-10	2018	Furthermore, SAMHD1 activation presents a pharmacologically actionable target through which HIV-1 infection can be subverted.IMPORTANCE Our experimental results demonstrate that SAMHD1 dephosphorylation at threonine-592 represents a central mechanism of HIV-1 restriction that is common to the three known families of IFNs.	Threonine	206-215	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	178-184
29669924-4	2018	To derestrict G1-phase dNTP supply, we CRISPR-inactivated SAMHD1 (which degrades dNTPs) in germinal center B cells.	Parathion	23-27	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	58-64
29669924-4	2018	To derestrict G1-phase dNTP supply, we CRISPR-inactivated SAMHD1 (which degrades dNTPs) in germinal center B cells.	Parathion	81-86	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	58-64
29669924-6	2018	We conclude that SAMHD1"s restriction of dNTP supply enhances AID"s mutagenicity and that the evolution of Ig hypermutation included the repurposing of antiviral mechanisms based on dNTP starvation.	Parathion	41-45	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	17-23
29610295-1	2018	Sterile alpha motif and HD-domain-containing protein 1 (SAMHD1) blocks replication of retroviruses and certain DNA viruses by reducing the intracellular dNTP pool.	Parathion	153-157	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-54
29583030-1	2018	Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the homeostatic balance of cellular dNTPs.	triphosphoric acid	106-118	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	77-83
29583030-1	2018	Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the homeostatic balance of cellular dNTPs.	Parathion	120-124	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	77-83
29583030-1	2018	Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the homeostatic balance of cellular dNTPs.	dntps	204-209	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	77-83
29610295-1	2018	Sterile alpha motif and HD-domain-containing protein 1 (SAMHD1) blocks replication of retroviruses and certain DNA viruses by reducing the intracellular dNTP pool.	Parathion	153-157	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	56-62
29610582-1	2018	Background: The restriction factor SAMHD1 regulates intracellular nucleotide level by degrading dNTPs and blocks the replication of retroviruses and DNA viruses in non-cycling cells, like macrophages or dendritic cells.	Parathion	96-101	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	35-41
29631596-8	2018	The SAMHD1 eQTL polymorphism rs6102991 showed decreased risk of non-CR marginally (P = 0.055).	Chromium	68-70	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	4-10
29610582-7	2018	By applying GFP- and neomycin-based reporter assays we found that the anti-L1 activity of SAMHD1 is regulated by phosphorylation at threonine 592 (T592).	Neomycin	21-29	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	90-96
29610582-7	2018	By applying GFP- and neomycin-based reporter assays we found that the anti-L1 activity of SAMHD1 is regulated by phosphorylation at threonine 592 (T592).	Threonine	132-141	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	90-96
29610582-10	2018	Interestingly, we found that SAMHD1 binds to ORF2 protein of L1 and that this interaction is regulated by T592 phosphorylation.	Allura Red AC Dye	106-110	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	29-35
29610582-15	2018	The finding that the phosphorylation of SAMHD1 at T592 regulates its activity against retroelements but not necessarily intracellular dNTP level suggests that the dNTP hydrolase activity might not be the only function of SAMHD1 important for its antiviral activity and for controlling autoimmunity.	Parathion	134-138	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	40-46
29515139-3	2018	We show that treatment of MDMs with neocarzinostatin, a compound that introduces double strand breaks (DBS) in genomic DNA, results in the decrease of phosphorylated SAMHD1, activating its antiviral activity and blocking HIV-1 infection.	Zinostatin	36-52	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	166-172
29515139-3	2018	We show that treatment of MDMs with neocarzinostatin, a compound that introduces double strand breaks (DBS) in genomic DNA, results in the decrease of phosphorylated SAMHD1, activating its antiviral activity and blocking HIV-1 infection.	dbs	103-106	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	166-172
29515139-7	2018	In response to Neocarzinostatin-induced DNA damage, the level of the CDK inhibitor p21cip1 increased which could account for the decrease of phosphorylated SAMHD1.	Zinostatin	15-31	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	156-162
29321329-1	2018	Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) regulates intracellular deoxynucleoside triphosphate (dNTP) levels and functions as a retroviral restriction factor through its dNTP triphosphohydrolase (dNTPase) activity.	deoxynucleoside triphosphate	88-116	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-54
29274141-0	2018	Acquired resistance of phosphatase and tensin homolog-deficient cells to poly(ADP-ribose) polymerase inhibitor and Ara-C mediated by 53BP1 loss and SAMHD1 overexpression.	Cytarabine	115-120	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	148-154
29274141-13	2018	SAMHD1 was overexpressed in all the variants and its knockout completely restored their sensitivity to Ara-C but did not affect their PARPi sensitivity.	Cytarabine	103-108	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
29321329-1	2018	Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) regulates intracellular deoxynucleoside triphosphate (dNTP) levels and functions as a retroviral restriction factor through its dNTP triphosphohydrolase (dNTPase) activity.	deoxynucleoside triphosphate	88-116	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	56-62
29321329-1	2018	Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) regulates intracellular deoxynucleoside triphosphate (dNTP) levels and functions as a retroviral restriction factor through its dNTP triphosphohydrolase (dNTPase) activity.	Parathion	118-122	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-54
29321329-1	2018	Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) regulates intracellular deoxynucleoside triphosphate (dNTP) levels and functions as a retroviral restriction factor through its dNTP triphosphohydrolase (dNTPase) activity.	Parathion	118-122	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	56-62
29321329-3	2018	This interaction mediates phosphorylation of SAMHD1 at threonine 592 (T592), which negatively regulates HIV-1 restriction.	Threonine	55-64	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	45-51
29321329-11	2018	These findings identify a new functional domain of SAMHD1 important for its structural integrity, enzyme activity, phosphorylation, and HIV-1 restriction.IMPORTANCE SAMHD1 is the first mammalian dNTPase identified as a restriction factor that inhibits HIV-1 replication by decreasing the intracellular dNTP pool in nondividing cells, although the critical mechanisms regulating SAMHD1 function remain unclear.	Parathion	195-199	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	51-57
29321329-11	2018	These findings identify a new functional domain of SAMHD1 important for its structural integrity, enzyme activity, phosphorylation, and HIV-1 restriction.IMPORTANCE SAMHD1 is the first mammalian dNTPase identified as a restriction factor that inhibits HIV-1 replication by decreasing the intracellular dNTP pool in nondividing cells, although the critical mechanisms regulating SAMHD1 function remain unclear.	Parathion	195-199	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	165-171
29321329-11	2018	These findings identify a new functional domain of SAMHD1 important for its structural integrity, enzyme activity, phosphorylation, and HIV-1 restriction.IMPORTANCE SAMHD1 is the first mammalian dNTPase identified as a restriction factor that inhibits HIV-1 replication by decreasing the intracellular dNTP pool in nondividing cells, although the critical mechanisms regulating SAMHD1 function remain unclear.	Parathion	195-199	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	165-171
30474474-1	2018	Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) is a mammalian dNTP hydrolase (dNTPase) and functions as a negative regulator in the efficacy of cytarabine treatment of acute myeloid leukemia (AML).	Cytarabine	161-171	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-54
29352181-6	2018	SAMHD1 regulates cellular deoxynucleotide levels and acts as a potential tumor suppressor in other leukemias.	deoxynucleotide	26-41	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
29084722-2	2018	SAMHD1 suppresses viral reverse transcription (RT) through depletion of cellular dNTPs but is naturally switched off by phosphorylation in a subpopulation of MDM found in a G1-like state.	Parathion	81-86	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
29084722-3	2018	We report that SAMHD1 was activated by dephosphorylation following ETO treatment, along with loss of expression of MCM2 and CDK1, and reduction in dNTP levels.	Etoposide	67-70	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	15-21
29084722-3	2018	We report that SAMHD1 was activated by dephosphorylation following ETO treatment, along with loss of expression of MCM2 and CDK1, and reduction in dNTP levels.	Parathion	147-151	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	15-21
29084722-5	2018	The ETO-induced block was completely rescued by depletion of SAMHD1 in MDM Concordantly, infection by HIV-2 and SIVsm encoding the SAMHD1 antagonist Vpx was insensitive to ETO treatment.	Etoposide	4-7	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	61-67
29084722-5	2018	The ETO-induced block was completely rescued by depletion of SAMHD1 in MDM Concordantly, infection by HIV-2 and SIVsm encoding the SAMHD1 antagonist Vpx was insensitive to ETO treatment.	Etoposide	4-7	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	131-137
29911928-1	2018	Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) is a mammalian dNTP hydrolase that acts as a negative regulator in the efficacy of cytarabine treatment against acute myeloid leukemia (AML).	Cytarabine	147-157	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-54
29911928-1	2018	Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) is a mammalian dNTP hydrolase that acts as a negative regulator in the efficacy of cytarabine treatment against acute myeloid leukemia (AML).	Cytarabine	147-157	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	56-62
30039733-1	2018	SAMHD1 is the major catabolic enzyme regulating the intracellular concentrations of DNA precursors (dNTPs).	dntps	100-105	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
30039733-2	2018	The S-phase kinase CDK2-cyclinA phosphorylates SAMHD1 at Thr-592.	Threonine	57-60	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	47-53
30039733-7	2018	SAMHD1 turn-over indicates that Thr-592 phosphorylation does not cause rapid protein degradation.	Threonine	32-35	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
30474474-1	2018	Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) is a mammalian dNTP hydrolase (dNTPase) and functions as a negative regulator in the efficacy of cytarabine treatment of acute myeloid leukemia (AML).	Cytarabine	161-171	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	56-62
30039733-8	2018	Furthermore, SAMHD1 influenced the size of the four dNTP pools independently of its phosphorylation.	Parathion	52-56	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	13-19
28502830-5	2017	However, SAMHD1 also can act as a resistance factor to nucleoside-based chemotherapies by hydrolyzing their active triphosphate metabolites, thereby reducing response of various malignancies to these anticancer drugs.	Nucleosides	55-65	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	9-15
30039733-9	2018	Our findings reveal that SAMHD1 is active during the entire cell cycle and performs an important regulatory role during S-phase by contributing with ribonucleotide reductase to maintain dNTP pool balance for proper DNA replication.	Parathion	186-190	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	25-31
28398823-5	2017	SAMHD1 is a triphosphate hydrolase, whose function involves regulation of deoxynucleotide triphosphate pools.	deoxynucleotide triphosphate	74-102	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
28931685-4	2017	SAMHD1 has been reported to be able to degrade dNTPs and viral nucleic acids, which may both hamper HIV-1 reverse transcription.	dntps	47-52	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
30656243-1	2018	Background: Sterile alpha motif and histidine/aspartic acid domain-containing protein (SAMHD1) is a dNTP triphosphorylase that reduces cellular dNTP levels in non-dividing cells, such as macrophages.	Parathion	100-104	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	87-93
30656243-2	2018	Since dNTPs are required for reverse transcription, HIV-2 and most SIVs encode a Vpx protein that promotes proteasomal degradation of SAMHD1.	Parathion	6-11	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	134-140
29249320-1	2018	SAMHD1 restricts lentiviruses by limiting availability of deoxynucleoside triphosphates for reverse transcription.	deoxynucleoside triphosphates	58-87	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
28969870-1	2017	SAMHD1 (sterile alpha motif and histidine (H) aspartate (D) domain-containing protein 1) is known for its antiviral activity of hydrolysing deoxynucleotides required for virus replication.	Histidine	32-41	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
29176984-6	2017	Sterile alpha motif and HD-domain containing protein 1 (SAMHD1) is the mammalian deoxynucleoside triphosphate triphosphohydrolase responsible for regulating intracellular dNTP pools and restricting the replication of HIV-1 in non-dividing myeloid cells and quiescent CD4+ T-cells.	Parathion	171-175	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	56-62
28871089-0	2017	CD81 association with SAMHD1 enhances HIV-1 reverse transcription by increasing dNTP levels.	Parathion	80-84	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	22-28
28871089-4	2017	Consequently, CD81 depletion results in SAMHD1 increased expression, decreasing the availability of deoxynucleoside triphosphates (dNTP) and thus HIV-1 reverse transcription.	deoxynucleoside triphosphates	100-129	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	40-46
28871089-4	2017	Consequently, CD81 depletion results in SAMHD1 increased expression, decreasing the availability of deoxynucleoside triphosphates (dNTP) and thus HIV-1 reverse transcription.	Parathion	131-135	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	40-46
28871089-6	2017	Our results demonstrate that the interaction of CD81 with SAMHD1 controls the metabolic rate of HIV-1 replication by tuning the availability of building blocks for reverse transcription, namely dNTPs.	Parathion	194-199	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	58-64
28502830-1	2017	Sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1) is a (deoxy)guanosine triphosphate (dGTP/GTP)-activated deoxyribonucleoside triphosphate (dNTP) triphosphohydrolase involved in cellular dNTP homoeostasis.	deoxyguanosine triphosphate	90-119	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-75
28502830-1	2017	Sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1) is a (deoxy)guanosine triphosphate (dGTP/GTP)-activated deoxyribonucleoside triphosphate (dNTP) triphosphohydrolase involved in cellular dNTP homoeostasis.	deoxyguanosine triphosphate	90-119	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	77-83
28502830-1	2017	Sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1) is a (deoxy)guanosine triphosphate (dGTP/GTP)-activated deoxyribonucleoside triphosphate (dNTP) triphosphohydrolase involved in cellular dNTP homoeostasis.	deoxyguanosine triphosphate	121-125	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-75
28502830-1	2017	Sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1) is a (deoxy)guanosine triphosphate (dGTP/GTP)-activated deoxyribonucleoside triphosphate (dNTP) triphosphohydrolase involved in cellular dNTP homoeostasis.	deoxyguanosine triphosphate	121-125	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	77-83
28502830-1	2017	Sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1) is a (deoxy)guanosine triphosphate (dGTP/GTP)-activated deoxyribonucleoside triphosphate (dNTP) triphosphohydrolase involved in cellular dNTP homoeostasis.	Guanosine Triphosphate	122-125	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-75
28502830-1	2017	Sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1) is a (deoxy)guanosine triphosphate (dGTP/GTP)-activated deoxyribonucleoside triphosphate (dNTP) triphosphohydrolase involved in cellular dNTP homoeostasis.	Guanosine Triphosphate	122-125	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	77-83
28502830-1	2017	Sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1) is a (deoxy)guanosine triphosphate (dGTP/GTP)-activated deoxyribonucleoside triphosphate (dNTP) triphosphohydrolase involved in cellular dNTP homoeostasis.	triphosphoric acid	107-119	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-75
28502830-1	2017	Sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1) is a (deoxy)guanosine triphosphate (dGTP/GTP)-activated deoxyribonucleoside triphosphate (dNTP) triphosphohydrolase involved in cellular dNTP homoeostasis.	triphosphoric acid	107-119	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	77-83
28502830-1	2017	Sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1) is a (deoxy)guanosine triphosphate (dGTP/GTP)-activated deoxyribonucleoside triphosphate (dNTP) triphosphohydrolase involved in cellular dNTP homoeostasis.	Parathion	175-179	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-75
28502830-1	2017	Sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1) is a (deoxy)guanosine triphosphate (dGTP/GTP)-activated deoxyribonucleoside triphosphate (dNTP) triphosphohydrolase involved in cellular dNTP homoeostasis.	Parathion	175-179	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	77-83
28502830-5	2017	However, SAMHD1 also can act as a resistance factor to nucleoside-based chemotherapies by hydrolyzing their active triphosphate metabolites, thereby reducing response of various malignancies to these anticancer drugs.	triphosphoric acid	115-127	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	9-15
28502830-1	2017	Sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1) is a (deoxy)guanosine triphosphate (dGTP/GTP)-activated deoxyribonucleoside triphosphate (dNTP) triphosphohydrolase involved in cellular dNTP homoeostasis.	Parathion	222-226	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-75
28502830-1	2017	Sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1) is a (deoxy)guanosine triphosphate (dGTP/GTP)-activated deoxyribonucleoside triphosphate (dNTP) triphosphohydrolase involved in cellular dNTP homoeostasis.	Parathion	222-226	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	77-83
28502830-8	2017	Our time-dependent analyses of The Cancer Genome Atlas (TCGA) AML cohort indicate that high expression of SAMHD1, even though it critically limits the efficacy of high-dose ara-C therapy, might be associated with more favorable disease progression.	Cytarabine	173-178	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	106-112
28321930-1	2017	The human sterile alpha motif and HD domain-containing protein 1 (SAMHD1) is a retroviral restriction factor in myeloid cells and non-cycling CD4+ T cells, a feature imputed to its phosphohydrolase activity-the enzyme depletes the cellular dNTP levels inhibiting reverse transcription.	Parathion	240-244	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	10-64
28978134-1	2017	SAM domain and HD domain containing protein 1 (SAMHD1) is a deoxynucleotide triphosphohydrolase (dNTPase) that inhibits retroviruses by depleting intracellular deoxynucleotide triphosphates (dNTPs) in non-cycling myeloid cells.	deoxynucleotide triphosphates	160-189	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	47-53
28978134-1	2017	SAM domain and HD domain containing protein 1 (SAMHD1) is a deoxynucleotide triphosphohydrolase (dNTPase) that inhibits retroviruses by depleting intracellular deoxynucleotide triphosphates (dNTPs) in non-cycling myeloid cells.	dntps	191-196	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	47-53
28978134-4	2017	SAMHD1 is acetylated at residue lysine 405 (K405) in vitro and in vivo by an acetylatransferase, arrest defective protein 1 (ARD1).	Lysine	32-38	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
28978134-4	2017	SAMHD1 is acetylated at residue lysine 405 (K405) in vitro and in vivo by an acetylatransferase, arrest defective protein 1 (ARD1).	methacrylamide	44-48	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
28321930-1	2017	The human sterile alpha motif and HD domain-containing protein 1 (SAMHD1) is a retroviral restriction factor in myeloid cells and non-cycling CD4+ T cells, a feature imputed to its phosphohydrolase activity-the enzyme depletes the cellular dNTP levels inhibiting reverse transcription.	Parathion	240-244	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	66-72
28321930-2	2017	The functionally active form of SAMHD1 is an allosterically triggered tetramer which utilizes GTP-Mg+2 -dNTP cross bridges to link and stabilize adjacent monomers.	gtp-mg+2 -dntp	94-108	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	32-38
28586337-0	2017	Corrigendum: SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.	Cytarabine	39-49	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	13-19
28444859-1	2017	The enzyme, sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) diminishes infection of human immunodeficiency virus type 1 (HIV-1) by hydrolyzing intracellular deoxynucleotide triphosphates (dNTPs) in myeloid cells and resting CD4+ T cells.	deoxynucleotide triphosphates	194-223	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	89-95
28444859-1	2017	The enzyme, sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) diminishes infection of human immunodeficiency virus type 1 (HIV-1) by hydrolyzing intracellular deoxynucleotide triphosphates (dNTPs) in myeloid cells and resting CD4+ T cells.	dntps	225-230	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	89-95
28436707-4	2017	Expanding the clinically relevant substrates of SAMHD1, we demonstrate that THP-1 CRISPR/Cas9 cells lacking a functional SAMHD1 gene showed increased sensitivity to the antimetabolites nelarabine, fludarabine, decitabine, vidarabine, clofarabine, and trifluridine.	nelarabine	185-195	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	121-127
28436707-4	2017	Expanding the clinically relevant substrates of SAMHD1, we demonstrate that THP-1 CRISPR/Cas9 cells lacking a functional SAMHD1 gene showed increased sensitivity to the antimetabolites nelarabine, fludarabine, decitabine, vidarabine, clofarabine, and trifluridine.	Decitabine	210-220	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	48-54
28436707-1	2017	Recently, we demonstrated that sterile alpha motif and HD domain containing protein 1 (SAMHD1) is a major barrier in acute myelogenous leukemia (AML) cells to the cytotoxicity of cytarabine (ara-C), the most important drug in AML treatment.	Cytarabine	179-189	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	87-93
28436707-4	2017	Expanding the clinically relevant substrates of SAMHD1, we demonstrate that THP-1 CRISPR/Cas9 cells lacking a functional SAMHD1 gene showed increased sensitivity to the antimetabolites nelarabine, fludarabine, decitabine, vidarabine, clofarabine, and trifluridine.	Decitabine	210-220	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	121-127
28436707-1	2017	Recently, we demonstrated that sterile alpha motif and HD domain containing protein 1 (SAMHD1) is a major barrier in acute myelogenous leukemia (AML) cells to the cytotoxicity of cytarabine (ara-C), the most important drug in AML treatment.	Cytarabine	191-196	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	87-93
28436707-4	2017	Expanding the clinically relevant substrates of SAMHD1, we demonstrate that THP-1 CRISPR/Cas9 cells lacking a functional SAMHD1 gene showed increased sensitivity to the antimetabolites nelarabine, fludarabine, decitabine, vidarabine, clofarabine, and trifluridine.	nelarabine	185-195	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	48-54
28436707-4	2017	Expanding the clinically relevant substrates of SAMHD1, we demonstrate that THP-1 CRISPR/Cas9 cells lacking a functional SAMHD1 gene showed increased sensitivity to the antimetabolites nelarabine, fludarabine, decitabine, vidarabine, clofarabine, and trifluridine.	Vidarabine	222-232	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	48-54
28436707-4	2017	Expanding the clinically relevant substrates of SAMHD1, we demonstrate that THP-1 CRISPR/Cas9 cells lacking a functional SAMHD1 gene showed increased sensitivity to the antimetabolites nelarabine, fludarabine, decitabine, vidarabine, clofarabine, and trifluridine.	Vidarabine	222-232	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	121-127
28436707-4	2017	Expanding the clinically relevant substrates of SAMHD1, we demonstrate that THP-1 CRISPR/Cas9 cells lacking a functional SAMHD1 gene showed increased sensitivity to the antimetabolites nelarabine, fludarabine, decitabine, vidarabine, clofarabine, and trifluridine.	Clofarabine	234-245	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	48-54
28436707-4	2017	Expanding the clinically relevant substrates of SAMHD1, we demonstrate that THP-1 CRISPR/Cas9 cells lacking a functional SAMHD1 gene showed increased sensitivity to the antimetabolites nelarabine, fludarabine, decitabine, vidarabine, clofarabine, and trifluridine.	Clofarabine	234-245	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	121-127
28436707-4	2017	Expanding the clinically relevant substrates of SAMHD1, we demonstrate that THP-1 CRISPR/Cas9 cells lacking a functional SAMHD1 gene showed increased sensitivity to the antimetabolites nelarabine, fludarabine, decitabine, vidarabine, clofarabine, and trifluridine.	Trifluridine	251-263	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	48-54
28436707-4	2017	Expanding the clinically relevant substrates of SAMHD1, we demonstrate that THP-1 CRISPR/Cas9 cells lacking a functional SAMHD1 gene showed increased sensitivity to the antimetabolites nelarabine, fludarabine, decitabine, vidarabine, clofarabine, and trifluridine.	Trifluridine	251-263	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	121-127
28436707-5	2017	Within this Extra View, we discuss and build upon both these and our previously reported findings, and propose SAMHD1 is likely active against a variety of nucleoside analog antimetabolites present in anti-cancer chemotherapies.	Nucleosides	156-166	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	111-117
28251415-1	2017	The human sterile alpha motif SAM and HD domain-containing protein 1 (SAMHD1) restricts in non-cycling cells type the infection of a large range of retroviruses including HIV-1, reducing the intracellular pool concentration of deoxynucleoside triphosphates (dNTPs) required for the reverse transcription of the viral genome.	deoxynucleoside triphosphates	227-256	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	70-76
28359840-1	2017	SAMHD1 is a triphosphohydrolase that restricts HIV-1 by limiting the intracellular dNTP pool required for reverse transcription.	Parathion	83-87	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
28359840-4	2017	Here, we show that SAMHD1-induced degradation by HIV-2 Vpx affects the dNTP pool and HIV-1 replication capacity in the presence of the 3"-azido-3"-deoxythymidine (AZT) in cycling cells.	Parathion	71-75	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	19-25
28359840-4	2017	Here, we show that SAMHD1-induced degradation by HIV-2 Vpx affects the dNTP pool and HIV-1 replication capacity in the presence of the 3"-azido-3"-deoxythymidine (AZT) in cycling cells.	Zidovudine	135-161	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	19-25
28359840-4	2017	Here, we show that SAMHD1-induced degradation by HIV-2 Vpx affects the dNTP pool and HIV-1 replication capacity in the presence of the 3"-azido-3"-deoxythymidine (AZT) in cycling cells.	Zidovudine	163-166	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	19-25
28359840-5	2017	Similarly, in SAMHD1 knockout cells, HIV-1 showed increased replicative capacity in the presence of nucleoside inhibitors, especially AZT, that was reverted by re-expression of wild type SAMHD1.	Nucleosides	100-110	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	14-20
28359840-5	2017	Similarly, in SAMHD1 knockout cells, HIV-1 showed increased replicative capacity in the presence of nucleoside inhibitors, especially AZT, that was reverted by re-expression of wild type SAMHD1.	Nucleosides	100-110	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	187-193
28359840-5	2017	Similarly, in SAMHD1 knockout cells, HIV-1 showed increased replicative capacity in the presence of nucleoside inhibitors, especially AZT, that was reverted by re-expression of wild type SAMHD1.	Zidovudine	134-137	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	14-20
28359840-5	2017	Similarly, in SAMHD1 knockout cells, HIV-1 showed increased replicative capacity in the presence of nucleoside inhibitors, especially AZT, that was reverted by re-expression of wild type SAMHD1.	Zidovudine	134-137	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	187-193
28359840-8	2017	Our results demonstrate that SAMHD1 is active in HIV-1 permissive cells, does not modify susceptibility to HIV-1 infection but strongly affects sensitivity to nucleoside inhibitors.	Nucleosides	159-169	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	29-35
28229507-4	2017	Most of the studied SAMHD1 AGS mutants exhibit defects in the ability to oligomerize, decrease the levels of cellular deoxynucleotide triphosphates in human cells, localize exclusively to the nucleus, and restrict HIV-1 infection.	deoxynucleotide triphosphates	118-147	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	20-26
28251415-1	2017	The human sterile alpha motif SAM and HD domain-containing protein 1 (SAMHD1) restricts in non-cycling cells type the infection of a large range of retroviruses including HIV-1, reducing the intracellular pool concentration of deoxynucleoside triphosphates (dNTPs) required for the reverse transcription of the viral genome.	dntps	258-263	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	70-76
28251415-3	2017	In this work, two SAMHD1 three-dimensional models have been investigated through classical molecular dynamics simulation, to define the role of cofactors and metal ions in the association of the tetrameric active form.	Metals	158-163	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	18-24
27991919-0	2017	SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.	Cytarabine	26-36	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
28202763-7	2017	Importantly, altering the intracellular zinc concentration by treatment with the zinc chelator N,N,N"-tetrakis-(2"-pyridylmethyl)ethylenediamine (TPEN) potently blocked Vpx-mediated SAMHD1 degradation and inhibited wild-type SIVmac (simian immunodeficiency virus of macaques) infection of myeloid cells, even in the presence of Vpx.	n,n,n"-tetrakis-(2"-pyridylmethyl)ethylenediamine	95-144	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	182-188
28202763-7	2017	Importantly, altering the intracellular zinc concentration by treatment with the zinc chelator N,N,N"-tetrakis-(2"-pyridylmethyl)ethylenediamine (TPEN) potently blocked Vpx-mediated SAMHD1 degradation and inhibited wild-type SIVmac (simian immunodeficiency virus of macaques) infection of myeloid cells, even in the presence of Vpx.	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	146-150	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	182-188
28220857-0	2017	SAMHD1 enhances nucleoside-analogue efficacy against HIV-1 in myeloid cells.	Nucleosides	16-26	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
28220857-1	2017	SAMHD1 is an intracellular enzyme that specifically degrades deoxynucleoside triphosphates into component nucleoside and inorganic triphosphate.	deoxynucleoside triphosphates	61-90	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
28220857-1	2017	SAMHD1 is an intracellular enzyme that specifically degrades deoxynucleoside triphosphates into component nucleoside and inorganic triphosphate.	nucleoside and inorganic triphosphate	106-143	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
28220857-2	2017	In myeloid-derived dendritic cells and macrophages as well as resting T-cells, SAMHD1 blocks HIV-1 infection through this dNTP triphosphohydrolase activity by reducing the cellular dNTP pool to a level that cannot support productive reverse transcription.	Parathion	122-126	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	79-85
28220857-3	2017	We now show that, in addition to this direct effect on virus replication, manipulating cellular SAMHD1 activity can significantly enhance or decrease the anti-HIV-1 efficacy of nucleotide analogue reverse transcription inhibitors presumably as a result of modulating dNTP pools that compete for recruitment by viral polymerases.	Parathion	267-271	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	96-102
28401188-2	2017	We identified sterile alpha motif and HD domain-containing protein 1 (SAMHD1) as an ara-CTPase that protects cancer cells from cytarabine-induced toxicity.	Cytarabine	127-137	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	14-68
28401188-2	2017	We identified sterile alpha motif and HD domain-containing protein 1 (SAMHD1) as an ara-CTPase that protects cancer cells from cytarabine-induced toxicity.	Cytarabine	127-137	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	70-76
28401188-3	2017	Therefore, we propose targeting SAMHD1 as a strategy to potentiate cytarabine and possibly other antimetabolite-based therapies.	Cytarabine	67-77	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	32-38
28067901-0	2017	Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.	Cytarabine	49-59	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	10-16
28067901-5	2017	Here we demonstrate that the deoxynucleoside triphosphate (dNTP) triphosphohydrolase SAM domain and HD domain 1 (SAMHD1) promotes the detoxification of intracellular ara-CTP pools.	ara-ctp	166-173	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	113-119
28067901-6	2017	Recombinant SAMHD1 exhibited ara-CTPase activity in vitro, and cells in which SAMHD1 expression was transiently reduced by treatment with the simian immunodeficiency virus (SIV) protein Vpx were dramatically more sensitive to ara-C-induced cytotoxicity.	Cytarabine	29-34	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	12-18
28067901-7	2017	CRISPR-Cas9-mediated disruption of the gene encoding SAMHD1 sensitized cells to ara-C, and this sensitivity could be abrogated by ectopic expression of wild-type (WT), but not dNTPase-deficient, SAMHD1.	Cytarabine	80-85	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	53-59
28067901-9	2017	Finally, we identified SAMHD1 as a risk factor in cohorts of both pediatric and adult patients with de novo AML who received ara-C treatment.	Cytarabine	125-130	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	23-29
28067901-10	2017	Thus, SAMHD1 expression levels dictate patient sensitivity to ara-C, providing proof-of-concept that the targeting of SAMHD1 by Vpx could be an attractive therapeutic strategy for potentiating ara-C efficacy in hematological malignancies.	Cytarabine	62-67	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	6-12
28067901-10	2017	Thus, SAMHD1 expression levels dictate patient sensitivity to ara-C, providing proof-of-concept that the targeting of SAMHD1 by Vpx could be an attractive therapeutic strategy for potentiating ara-C efficacy in hematological malignancies.	Cytarabine	193-198	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	118-124
28228523-2	2017	In this context, dNTP triphosphohydrolase SAM domain and HD domain-containing protein 1 (SAMHD1) has been identified as a restriction factor, lowering the concentration of dNTP substrates to limit RT.	Parathion	17-21	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	89-95
27991919-4	2017	SAMHD1 is a deoxynucleoside triphosphate (dNTP) triphosphohydrolase that cleaves physiological dNTPs into deoxyribonucleosides and inorganic triphosphate.	Parathion	95-100	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
27991919-4	2017	SAMHD1 is a deoxynucleoside triphosphate (dNTP) triphosphohydrolase that cleaves physiological dNTPs into deoxyribonucleosides and inorganic triphosphate.	Deoxyribonucleosides	106-126	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
27991919-4	2017	SAMHD1 is a deoxynucleoside triphosphate (dNTP) triphosphohydrolase that cleaves physiological dNTPs into deoxyribonucleosides and inorganic triphosphate.	triphosphoric acid	131-153	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
27991919-5	2017	Although it has been postulated that SAMHD1 sensitizes cancer cells to nucleoside-analog derivatives through the depletion of competing dNTPs, we show here that SAMHD1 reduces Ara-C cytotoxicity in AML cells.	Nucleosides	71-81	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	37-43
27991919-5	2017	Although it has been postulated that SAMHD1 sensitizes cancer cells to nucleoside-analog derivatives through the depletion of competing dNTPs, we show here that SAMHD1 reduces Ara-C cytotoxicity in AML cells.	Nucleosides	71-81	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	161-167
27991919-5	2017	Although it has been postulated that SAMHD1 sensitizes cancer cells to nucleoside-analog derivatives through the depletion of competing dNTPs, we show here that SAMHD1 reduces Ara-C cytotoxicity in AML cells.	Parathion	136-141	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	37-43
27991919-5	2017	Although it has been postulated that SAMHD1 sensitizes cancer cells to nucleoside-analog derivatives through the depletion of competing dNTPs, we show here that SAMHD1 reduces Ara-C cytotoxicity in AML cells.	Parathion	136-141	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	161-167
27991919-5	2017	Although it has been postulated that SAMHD1 sensitizes cancer cells to nucleoside-analog derivatives through the depletion of competing dNTPs, we show here that SAMHD1 reduces Ara-C cytotoxicity in AML cells.	Cytarabine	176-181	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	161-167
27991919-6	2017	Mechanistically, dGTP-activated SAMHD1 hydrolyzes Ara-CTP, which results in a drastic reduction of Ara-CTP in leukemic cells.	deoxyguanosine triphosphate	17-21	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	32-38
27991919-6	2017	Mechanistically, dGTP-activated SAMHD1 hydrolyzes Ara-CTP, which results in a drastic reduction of Ara-CTP in leukemic cells.	Arabinofuranosylcytosine Triphosphate	50-57	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	32-38
27991919-6	2017	Mechanistically, dGTP-activated SAMHD1 hydrolyzes Ara-CTP, which results in a drastic reduction of Ara-CTP in leukemic cells.	Arabinofuranosylcytosine Triphosphate	99-106	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	32-38
27991919-7	2017	Loss of SAMHD1 activity-through genetic depletion, mutational inactivation of its triphosphohydrolase activity or proteasomal degradation using specialized, virus-like particles-potentiates the cytotoxicity of Ara-C in AML cells.	Cytarabine	210-215	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	8-14
27991919-8	2017	In mouse models of retroviral AML transplantation, as well as in retrospective analyses of adult patients with AML, the response to Ara-C-containing therapy was inversely correlated with SAMHD1 expression.	Cytarabine	132-137	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	187-193
27991919-9	2017	These results identify SAMHD1 as a potential biomarker for the stratification of patients with AML who might best respond to Ara-C-based therapy and as a target for treating Ara-C-refractory AML.	Cytarabine	125-130	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	23-29
27991919-9	2017	These results identify SAMHD1 as a potential biomarker for the stratification of patients with AML who might best respond to Ara-C-based therapy and as a target for treating Ara-C-refractory AML.	Cytarabine	174-179	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	23-29
27909056-1	2017	SAMHD1 is a phosphohydrolase maintaining cellular dNTP homeostasis but also acts as a critical regulator in innate immune responses due to its antiviral activity and association with autoimmune disease, leading to aberrant activation of interferon.	Parathion	50-54	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
27920203-1	2017	The triphosphohydrolase SAMHD1 (sterile alpha motif and histidine-aspartate domain-containing protein 1) restricts HIV-1 replication in nondividing myeloid cells by depleting the dNTP pool, preventing reverse transcription.	Parathion	179-183	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	24-30
27920203-3	2017	Human SAMHD1 is regulated by phosphorylation of its carboxyl terminus at Thr-592, which abrogates its antiviral function yet has only a small effect on its phosphohydrolase activity.	Threonine	73-76	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	6-12
27920203-7	2017	Mass spectrometry analysis showed that SAMHD1 is phosphorylated at several amino acid residues, one of which (Thr-634) is homologous to Thr-592.	Threonine	110-113	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	39-45
27920203-7	2017	Mass spectrometry analysis showed that SAMHD1 is phosphorylated at several amino acid residues, one of which (Thr-634) is homologous to Thr-592.	Threonine	136-139	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	39-45
27929746-1	2017	Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) is a mammalian dNTP hydrolase (dNTPase) that regulates intracellular dNTP balance.	Parathion	79-83	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-54
27929746-1	2017	Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) is a mammalian dNTP hydrolase (dNTPase) that regulates intracellular dNTP balance.	Parathion	79-83	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	56-62
28046007-1	2017	SAMHD1 hydrolyzes 2"-deoxynucleoside-5"-triphosphates (dNTPs) into 2"-deoxynucleosides and inorganic triphosphate products.	2"-deoxynucleoside-5"-triphosphates	18-53	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
28046007-1	2017	SAMHD1 hydrolyzes 2"-deoxynucleoside-5"-triphosphates (dNTPs) into 2"-deoxynucleosides and inorganic triphosphate products.	dntps	55-60	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
28046007-1	2017	SAMHD1 hydrolyzes 2"-deoxynucleoside-5"-triphosphates (dNTPs) into 2"-deoxynucleosides and inorganic triphosphate products.	2"-deoxynucleosides	67-86	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
28046007-1	2017	SAMHD1 hydrolyzes 2"-deoxynucleoside-5"-triphosphates (dNTPs) into 2"-deoxynucleosides and inorganic triphosphate products.	triphosphoric acid	91-113	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
28046007-2	2017	In this paper, we evaluated the impact of 2" sugar moiety substitution for different nucleotides on being substrates for SAMHD1 and mechanisms of actions for the results.	Sugars	45-50	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	121-127
28046007-3	2017	We found that dNTPs ((2"R)-2"-H) are only permissive in the catalytic site of SAMHD1 due to L150 exclusion of (2"R)-2"-F and (2"R)-2"-OH nucleotides.	dntps	14-19	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	78-84
28046007-3	2017	We found that dNTPs ((2"R)-2"-H) are only permissive in the catalytic site of SAMHD1 due to L150 exclusion of (2"R)-2"-F and (2"R)-2"-OH nucleotides.	galactose-1-phosphate	22-25	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	78-84
28046007-3	2017	We found that dNTPs ((2"R)-2"-H) are only permissive in the catalytic site of SAMHD1 due to L150 exclusion of (2"R)-2"-F and (2"R)-2"-OH nucleotides.	(2"r)-2"-f	110-120	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	78-84
28046007-3	2017	We found that dNTPs ((2"R)-2"-H) are only permissive in the catalytic site of SAMHD1 due to L150 exclusion of (2"R)-2"-F and (2"R)-2"-OH nucleotides.	(2"r)-2"-oh nucleotides	125-148	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	78-84
28046007-4	2017	However, arabinose ((2"S)-2"-OH) nucleoside-5"-triphosphates analogs are permissive to bind in the catalytic site and be hydrolyzed by SAMHD1.	nucleoside-5"-triphosphates	33-60	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	135-141
28046007-5	2017	Moreover, when the (2"S)-2" sugar moiety is increased to a (2"S)-2"-methyl as with the SMDU-TP analog, we detect inhibition of SAMHD1"s dNTPase activity.	(2"s)-2"	19-27	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	127-133
28046007-5	2017	Moreover, when the (2"S)-2" sugar moiety is increased to a (2"S)-2"-methyl as with the SMDU-TP analog, we detect inhibition of SAMHD1"s dNTPase activity.	smdu-tp	87-94	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	127-133
28046007-6	2017	Our computational modeling suggests that (2"S)-2"-methyl sugar moiety clashing with the Y374 of SAMHD1.	Sugars	57-62	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	96-102
28046007-9	2017	Importantly, our data is beneficial for understanding if FDA-approved antiviral and anticancer nucleosides are hydrolyzed by SAMHD1 in vivo.	Nucleosides	95-106	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	125-131
27889686-8	2017	In contrast, inhibition of miR-181 in a CD4+ T-cell line significantly increased the level of SAMHD1 protein expression.	mir-181	27-34	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	94-100
27889686-9	2017	Our results demonstrate that miR-181 is an important regulator of SAMHD1 protein expression in neoplastic CD4+ T-cells, likely through a mechanism of translational inhibition.	mir-181	29-36	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	66-72
27803699-3	2016	SAMHD1 reduces cellular deoxynucleoside triphosphate (dNTP) pools and affects viral reverse transcription step.	deoxynucleoside triphosphate	24-52	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
28203649-3	2016	We observed increased expression of heme and iron-regulated genes, previously shown to inhibit HIV-1, including ferroportin, IKBalpha, HO-1, p21, and SAM domain and HD domain-containing protein 1 (SAMHD1).	Heme	36-40	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	197-203
28203649-3	2016	We observed increased expression of heme and iron-regulated genes, previously shown to inhibit HIV-1, including ferroportin, IKBalpha, HO-1, p21, and SAM domain and HD domain-containing protein 1 (SAMHD1).	Iron	45-49	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	197-203
27815502-1	2016	SAMHD1 (sterile alpha motif and HD domain-containing protein 1) is a mammalian protein that regulates intracellular dNTP levels through its hydrolysis of dNTPs.	Parathion	116-120	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
27815502-1	2016	SAMHD1 (sterile alpha motif and HD domain-containing protein 1) is a mammalian protein that regulates intracellular dNTP levels through its hydrolysis of dNTPs.	Parathion	116-120	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	8-62
27815502-1	2016	SAMHD1 (sterile alpha motif and HD domain-containing protein 1) is a mammalian protein that regulates intracellular dNTP levels through its hydrolysis of dNTPs.	Parathion	154-159	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
27815502-1	2016	SAMHD1 (sterile alpha motif and HD domain-containing protein 1) is a mammalian protein that regulates intracellular dNTP levels through its hydrolysis of dNTPs.	Parathion	154-159	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	8-62
27815502-3	2016	We and others have reported that human SAMHD1 interacts with the cell cycle regulatory proteins cyclin A, CDK1, and CDK2, which mediates phosphorylation of SAMHD1 at threonine 592, a post-translational modification that has been implicated in abrogating SAMHD1 restriction function and ability to form stable tetramers.	Threonine	166-175	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	39-45
27815502-3	2016	We and others have reported that human SAMHD1 interacts with the cell cycle regulatory proteins cyclin A, CDK1, and CDK2, which mediates phosphorylation of SAMHD1 at threonine 592, a post-translational modification that has been implicated in abrogating SAMHD1 restriction function and ability to form stable tetramers.	Threonine	166-175	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	156-162
27815502-3	2016	We and others have reported that human SAMHD1 interacts with the cell cycle regulatory proteins cyclin A, CDK1, and CDK2, which mediates phosphorylation of SAMHD1 at threonine 592, a post-translational modification that has been implicated in abrogating SAMHD1 restriction function and ability to form stable tetramers.	Threonine	166-175	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	156-162
27775344-3	2016	Here we utilize a UV cross-linking method using 5-bromodeoxyuridine-substituted oligonucleotides coupled with high-resolution mass spectrometry to identify the binding site for single-stranded nucleic acids (ssNAs) on SAMHD1.	5-bromodeoxyuridine-substituted oligonucleotides	48-96	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	218-224
27803699-3	2016	SAMHD1 reduces cellular deoxynucleoside triphosphate (dNTP) pools and affects viral reverse transcription step.	Parathion	54-58	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
27566548-0	2016	Allosteric Activation of SAMHD1 Protein by Deoxynucleotide Triphosphate (dNTP)-dependent Tetramerization Requires dNTP Concentrations That Are Similar to dNTP Concentrations Observed in Cycling T Cells.	deoxynucleotide triphosphate	43-71	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	25-31
27588835-0	2016	Substrate Specificity of SAMHD1 Triphosphohydrolase Activity Is Controlled by Deoxyribonucleoside Triphosphates and Phosphorylation at Thr592.	deoxyribonucleoside triphosphates	78-111	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	25-31
27588835-1	2016	The sterile alpha motif (SAM) and histidine-aspartate (HD) domain containing protein 1 (SAMHD1) constitute a triphosphohydrolase that converts deoxyribonucleoside triphosphates (dNTPs) into deoxyribonucleosides and triphosphates.	Histidine	34-43	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	88-94
27588835-1	2016	The sterile alpha motif (SAM) and histidine-aspartate (HD) domain containing protein 1 (SAMHD1) constitute a triphosphohydrolase that converts deoxyribonucleoside triphosphates (dNTPs) into deoxyribonucleosides and triphosphates.	deoxyribonucleoside triphosphates	143-176	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	88-94
27588835-1	2016	The sterile alpha motif (SAM) and histidine-aspartate (HD) domain containing protein 1 (SAMHD1) constitute a triphosphohydrolase that converts deoxyribonucleoside triphosphates (dNTPs) into deoxyribonucleosides and triphosphates.	dntps	178-183	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	88-94
27588835-1	2016	The sterile alpha motif (SAM) and histidine-aspartate (HD) domain containing protein 1 (SAMHD1) constitute a triphosphohydrolase that converts deoxyribonucleoside triphosphates (dNTPs) into deoxyribonucleosides and triphosphates.	Deoxyribonucleosides	190-210	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	88-94
27588835-1	2016	The sterile alpha motif (SAM) and histidine-aspartate (HD) domain containing protein 1 (SAMHD1) constitute a triphosphohydrolase that converts deoxyribonucleoside triphosphates (dNTPs) into deoxyribonucleosides and triphosphates.	triphosphoric acid	163-176	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	88-94
27588835-8	2016	Strikingly, a phosphomimetic mutant, Thr592Asp SAMHD1 as well as phospho-Thr592, show a significantly altered substrate specificity, with the rate of dCTP hydrolysis being selectively reduced regardless of which dNTP binds at AS2.	2'-deoxycytidine 5'-triphosphate	150-154	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	47-53
27588835-8	2016	Strikingly, a phosphomimetic mutant, Thr592Asp SAMHD1 as well as phospho-Thr592, show a significantly altered substrate specificity, with the rate of dCTP hydrolysis being selectively reduced regardless of which dNTP binds at AS2.	Parathion	212-216	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	47-53
27588835-10	2016	Together, our results reveal multiple allosteric mechanisms for controlling the rate of dNTP destruction by SAMHD1.	Parathion	88-92	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	108-114
27566548-0	2016	Allosteric Activation of SAMHD1 Protein by Deoxynucleotide Triphosphate (dNTP)-dependent Tetramerization Requires dNTP Concentrations That Are Similar to dNTP Concentrations Observed in Cycling T Cells.	Parathion	73-77	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	25-31
27566548-0	2016	Allosteric Activation of SAMHD1 Protein by Deoxynucleotide Triphosphate (dNTP)-dependent Tetramerization Requires dNTP Concentrations That Are Similar to dNTP Concentrations Observed in Cycling T Cells.	Parathion	114-118	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	25-31
27566548-0	2016	Allosteric Activation of SAMHD1 Protein by Deoxynucleotide Triphosphate (dNTP)-dependent Tetramerization Requires dNTP Concentrations That Are Similar to dNTP Concentrations Observed in Cycling T Cells.	Parathion	114-118	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	25-31
27566548-1	2016	SAMHD1 is a dNTP hydrolase, whose activity is required for maintaining low dNTP concentrations in non-cycling T cells, dendritic cells, and macrophages.	Parathion	12-16	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
27566548-2	2016	SAMHD1-dependent dNTP depletion is thought to impair retroviral replication in these cells, but the relationship between the dNTPase activity and retroviral restriction is not fully understood.	Parathion	17-21	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
27566548-3	2016	In this study, we investigate allosteric activation of SAMHD1 by deoxynucleotide-dependent tetramerization and measure how the lifetime of the enzymatically active tetramer is affected by different dNTP ligands bound in the allosteric site.	deoxynucleotide	65-80	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	55-61
27566548-3	2016	In this study, we investigate allosteric activation of SAMHD1 by deoxynucleotide-dependent tetramerization and measure how the lifetime of the enzymatically active tetramer is affected by different dNTP ligands bound in the allosteric site.	Parathion	198-202	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	55-61
27566548-4	2016	The EC50dNTP values for SAMHD1 activation by dNTPs are in the 2-20 mum range, and the half-life of the assembled tetramer after deoxynucleotide depletion varies from minutes to hours depending on what dNTP is bound in the A2 allosteric site.	Parathion	45-50	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	24-30
27566548-4	2016	The EC50dNTP values for SAMHD1 activation by dNTPs are in the 2-20 mum range, and the half-life of the assembled tetramer after deoxynucleotide depletion varies from minutes to hours depending on what dNTP is bound in the A2 allosteric site.	Parathion	8-12	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	24-30
27511536-0	2016	Effects of T592 phosphomimetic mutations on tetramer stability and dNTPase activity of SAMHD1 can not explain the retroviral restriction defect.	Allura Red AC Dye	11-15	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	87-93
27387229-4	2016	Here, we found that, unlike conventional hydrolytic exoribonucleases, SAMHD1 requires inorganic phosphate to degrade RNA substrates and produces nucleotide diphosphates rather than nucleoside monophosphates, which indicated that SAMHD1 is a phosphorolytic but not hydrolytic 3"-5" exoribonuclease.	Phosphates	86-105	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	70-76
27387229-4	2016	Here, we found that, unlike conventional hydrolytic exoribonucleases, SAMHD1 requires inorganic phosphate to degrade RNA substrates and produces nucleotide diphosphates rather than nucleoside monophosphates, which indicated that SAMHD1 is a phosphorolytic but not hydrolytic 3"-5" exoribonuclease.	Phosphates	86-105	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	229-235
27387229-4	2016	Here, we found that, unlike conventional hydrolytic exoribonucleases, SAMHD1 requires inorganic phosphate to degrade RNA substrates and produces nucleotide diphosphates rather than nucleoside monophosphates, which indicated that SAMHD1 is a phosphorolytic but not hydrolytic 3"-5" exoribonuclease.	nucleotide diphosphates	145-168	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	70-76
27387229-4	2016	Here, we found that, unlike conventional hydrolytic exoribonucleases, SAMHD1 requires inorganic phosphate to degrade RNA substrates and produces nucleotide diphosphates rather than nucleoside monophosphates, which indicated that SAMHD1 is a phosphorolytic but not hydrolytic 3"-5" exoribonuclease.	nucleotide diphosphates	145-168	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	229-235
27387229-4	2016	Here, we found that, unlike conventional hydrolytic exoribonucleases, SAMHD1 requires inorganic phosphate to degrade RNA substrates and produces nucleotide diphosphates rather than nucleoside monophosphates, which indicated that SAMHD1 is a phosphorolytic but not hydrolytic 3"-5" exoribonuclease.	nucleoside monophosphates	181-206	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	70-76
27219130-9	2016	Overexpression of miR-181a counteracted induction of SAMHD1 expression by interferons, and inhibition of miR-181a mimicked interferons treatment.	mir-181a	18-26	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	53-59
27511536-2	2016	SAMHD1-mediated retroviral restriction is thought to result from the depletion of cellular dNTP pools, but it remains controversial whether the dNTPase activity of SAMHD1 is sufficient for restriction.	Parathion	91-95	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
27229711-7	2016	Moreover, HBV restriction by SAMHD1 was rescued by addition of deoxynucleosides.	deoxynucleosides	63-79	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	29-35
27179347-1	2016	SAMHD1 is a cellular protein that possesses dNTPase activity and inhibits retroviruses and DNA viruses through the depletion of cellular dNTPs.	Parathion	137-142	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
27179347-9	2016	These results indicate that SAMHD1 inhibits HBV replication at the reverse transcription step, most likely through the depletion of cellular dNTPs.	Parathion	141-146	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	28-34
27183329-1	2016	SAMHD1 limits HIV-1 infection in non-dividing myeloid cells by decreasing intracellular dNTP pools.	Parathion	88-92	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
27183329-6	2016	These alterations correlated with increased dNTP levels and more efficient HIV-1 infection in dividing SAMHD1 knockout cells relative to control.	Parathion	44-48	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	103-109
29963825-3	2016	This promotion is achieved by Vpx-induced formation of the CRL4E3 complex, which removes the endogenous SAMHD1 via proteasomal degradation.	3vw7	30-33	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	104-110
29963825-4	2016	Multiple domains of SAMHD1(e.g., N-terminus, nuclear localization signal, linker, HD domain, and C-terminus)are essential for Vpx-induced degradation.HIV-1that does not express Vpx is also evolved with mechanisms to bypass or suppress the antiviral function of SAMHD1,such as the tolerance against a low level of dNTPs and induction of SAMHD1 degradation through cyclin L2.Based on previous reports published chronologically, as well as the latest findings in the field, this review focuses on the mechanism of Vpx-mediated degradation of SAMHD1,and its promotion of HIV-1infection.	Parathion	313-318	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	20-26
26851491-0	2016	Dasatinib inhibits HIV-1 replication through the interference of SAMHD1 phosphorylation in CD4+ T cells.	Dasatinib	0-9	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	65-71
26851491-4	2016	We demonstrate that Dasatinib can actually interfere with SAMHD1 phosphorylation in human peripheral blood lymphocytes, preserving its antiviral activity against HIV-1.	Dasatinib	20-29	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	58-64
26851491-5	2016	Dasatinib prevented SAMHD1 phosphorylation in vitro and ex vivo, impairing HIV-1 reverse transcription and proviral integration.	Dasatinib	0-9	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	20-26
26851491-6	2016	This was the major mechanism of action because the presence of Vpx, which degrades SAMHD1, in HIV-1 virions impeded the inhibitory effect of Dasatinib on HIV-1 replication.	Dasatinib	141-150	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	83-89
26851491-8	2016	Finally, PBMCs from patients on chronic treatment with Dasatinib showed a lower level of SAMHD1 phosphorylation in response to activating stimuli and low susceptibility to HIV-1 infection ex vivo.	Dasatinib	55-64	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	89-95
26851491-9	2016	Consequently, Dasatinib is a compound currently used in clinic that preserves the antiviral function of SAMHD1.	Dasatinib	14-23	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	104-110
26542306-0	2016	Inhibition of herpes simplex virus type 1 by the CDK6 inhibitor PD-0332991 (palbociclib) through the control of SAMHD1.	palbociclib	64-74	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	112-118
26733158-1	2016	Sterile alpha motif and histidine-aspartate domain containing protein 1 (SAMHD1) is a triphosphohydrolase that catalyzes the conversion of deoxyribonucleoside triphosphate to deoxyribonucleoside and triphosphate.	deoxyribonucleoside triphosphate	139-171	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	73-79
26733158-1	2016	Sterile alpha motif and histidine-aspartate domain containing protein 1 (SAMHD1) is a triphosphohydrolase that catalyzes the conversion of deoxyribonucleoside triphosphate to deoxyribonucleoside and triphosphate.	deoxyribonucleoside and triphosphate	175-211	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	73-79
26733158-3	2016	Recent biochemical and biological studies have suggested that SAMHD1 restricts HIV-1 infection in non-cycling cells by limiting the pool of deoxyribonucleoside triphosphates, thereby interfering with HIV-1 reverse transcription.	deoxyribonucleoside triphosphates	140-173	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	62-68
26923586-6	2016	Dasatinib--a tyrosine-kinase inhibitor--blocked SAMHD1 phosphorylation induced by IL-2 and IL-7 and restored HIV-1 restriction.	Dasatinib	0-9	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	48-54
26542306-11	2016	Similarly, the restricting activity of SAMHD1 against DNA viruses suggests that control of dNTP availability is the major determinant of its antiviral activity.	Parathion	91-95	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	39-45
26496699-2	2015	SAMHD1 is a deoxynucleoside triphosphohydrolase that interferes with viral infection mostly by limiting the intracellular concentrations of dNTPs, while A3A is a cytidine deaminase that has been described to edit incoming vDNA.	Parathion	140-145	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
26438820-1	2015	Sterile alpha-motif/histidine-aspartate domain-containing protein (SAMHD1), a homo-tetrameric GTP/dGTP-dependent dNTP triphosphohydrolase, catalyzes the conversion of dNTP into deoxynucleoside and triphosphate.	Guanosine Triphosphate	94-97	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	67-73
26438820-1	2015	Sterile alpha-motif/histidine-aspartate domain-containing protein (SAMHD1), a homo-tetrameric GTP/dGTP-dependent dNTP triphosphohydrolase, catalyzes the conversion of dNTP into deoxynucleoside and triphosphate.	deoxyguanosine triphosphate	98-102	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	67-73
26438820-1	2015	Sterile alpha-motif/histidine-aspartate domain-containing protein (SAMHD1), a homo-tetrameric GTP/dGTP-dependent dNTP triphosphohydrolase, catalyzes the conversion of dNTP into deoxynucleoside and triphosphate.	Parathion	113-117	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	67-73
26438820-1	2015	Sterile alpha-motif/histidine-aspartate domain-containing protein (SAMHD1), a homo-tetrameric GTP/dGTP-dependent dNTP triphosphohydrolase, catalyzes the conversion of dNTP into deoxynucleoside and triphosphate.	deoxynucleoside	177-192	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	67-73
26438820-1	2015	Sterile alpha-motif/histidine-aspartate domain-containing protein (SAMHD1), a homo-tetrameric GTP/dGTP-dependent dNTP triphosphohydrolase, catalyzes the conversion of dNTP into deoxynucleoside and triphosphate.	triphosphoric acid	197-209	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	67-73
26438820-3	2015	Previous biochemical studies and crystal structures have revealed that SAMHD1 interconverts between an inactive monomeric or dimeric form and a dGTP/GTP-induced active tetrameric form.	deoxyguanosine triphosphate	144-148	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	71-77
26438820-3	2015	Previous biochemical studies and crystal structures have revealed that SAMHD1 interconverts between an inactive monomeric or dimeric form and a dGTP/GTP-induced active tetrameric form.	Guanosine Triphosphate	145-148	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	71-77
26438820-5	2015	Interestingly, the crystal structure showed that this novel SAMHD1 tetramer contains only GTP and has structural features distinct from the GTP/dNTP-bound SAMHD1 tetramer.	Guanosine Triphosphate	90-93	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	60-66
26438820-5	2015	Interestingly, the crystal structure showed that this novel SAMHD1 tetramer contains only GTP and has structural features distinct from the GTP/dNTP-bound SAMHD1 tetramer.	Guanosine Triphosphate	140-143	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	60-66
26438820-5	2015	Interestingly, the crystal structure showed that this novel SAMHD1 tetramer contains only GTP and has structural features distinct from the GTP/dNTP-bound SAMHD1 tetramer.	Parathion	144-148	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	60-66
26438820-5	2015	Interestingly, the crystal structure showed that this novel SAMHD1 tetramer contains only GTP and has structural features distinct from the GTP/dNTP-bound SAMHD1 tetramer.	Parathion	144-148	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	155-161
26655245-1	2016	SAMHD1 is a cellular dNTPase that restricts lentiviral infection presumably by lowering cellular dNTP levels to below a critical threshold required for reverse transcription; however, lowering cellular dNTP levels may not be the sole mechanism of restriction.	Parathion	21-25	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
26655245-1	2016	SAMHD1 is a cellular dNTPase that restricts lentiviral infection presumably by lowering cellular dNTP levels to below a critical threshold required for reverse transcription; however, lowering cellular dNTP levels may not be the sole mechanism of restriction.	Parathion	97-101	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
26655245-4	2016	Using hydroxyurea treatment to lower baseline dNTP levels in HeLa cells, we were able to document efficient SAMHD1 restriction without significant further reduction in dNTP levels by SAMHD1.	Hydroxyurea	6-17	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	108-114
26655245-4	2016	Using hydroxyurea treatment to lower baseline dNTP levels in HeLa cells, we were able to document efficient SAMHD1 restriction without significant further reduction in dNTP levels by SAMHD1.	Parathion	46-50	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	108-114
26655245-5	2016	These results argue against a requirement for additional myeloid-specific host factors for SAMHD1 function but further support the notion that SAMHD1 possesses an additional dNTP-independent function contributing to lentiviral restriction.	Parathion	174-178	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	143-149
26957197-1	2016	BACKGROUND: The antiviral restriction factor SAM domain and HD domain-containing protein 1 (SAMHD1) is a dNTP triphosphohydrolase and thereby contributes to the regulation of intracellular dNTP levels.	Parathion	105-109	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	45-90
26957197-1	2016	BACKGROUND: The antiviral restriction factor SAM domain and HD domain-containing protein 1 (SAMHD1) is a dNTP triphosphohydrolase and thereby contributes to the regulation of intracellular dNTP levels.	Parathion	105-109	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	92-98
26580513-1	2016	Human SAMHD1 (hSAMHD1) restricts HIV-1 infection in non-dividing cells by depleting intracellular dNTPs to limit viral reverse transcription.	Parathion	98-103	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	14-21
26580513-2	2016	Phosphorylation of hSAMHD1 at threonine (T) 592 by cyclin-dependent kinase (CDK) 1 and CDK2 negatively regulates HIV-1 restriction.	Threonine	30-39	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	19-26
26439297-1	2015	SAMHD1 is a triphosphohydrolase enzyme that controls the intracellular level of deoxyribonucleoside triphosphates (dNTPs) and plays a role in innate immune sensing and autoimmune disease.	deoxyribonucleoside triphosphates	80-113	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
26439297-1	2015	SAMHD1 is a triphosphohydrolase enzyme that controls the intracellular level of deoxyribonucleoside triphosphates (dNTPs) and plays a role in innate immune sensing and autoimmune disease.	dntps	115-120	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
26294762-0	2015	Impaired dNTPase activity of SAMHD1 by phosphomimetic mutation of Thr-592.	Threonine	66-69	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	29-35
26496699-3	2015	The restrictive phenotype of myeloid cells can be alleviated through the direct degradation of SAMHD1 by the HIV-2/SIVSM Vpx protein or else, at least in the case of HIV-1, by the exogenous supplementation of nucleosides that artificially overcome the catabolic activity of SAMHD1 on dNTPs.	Nucleosides	209-220	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	95-101
26496699-3	2015	The restrictive phenotype of myeloid cells can be alleviated through the direct degradation of SAMHD1 by the HIV-2/SIVSM Vpx protein or else, at least in the case of HIV-1, by the exogenous supplementation of nucleosides that artificially overcome the catabolic activity of SAMHD1 on dNTPs.	Nucleosides	209-220	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	274-280
26496699-3	2015	The restrictive phenotype of myeloid cells can be alleviated through the direct degradation of SAMHD1 by the HIV-2/SIVSM Vpx protein or else, at least in the case of HIV-1, by the exogenous supplementation of nucleosides that artificially overcome the catabolic activity of SAMHD1 on dNTPs.	Parathion	284-289	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	95-101
26496699-4	2015	Here, we have used Vpx and dNs to explore the relationship existing between vDNA cytidine deamination and SAMHD1 during HIV-1 or SIVMAC infection of primary dendritic cells.	Cytidine	81-89	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	106-112
26294762-1	2015	SAMHD1 is a cellular protein that plays key roles in HIV-1 restriction and regulation of cellular dNTP levels.	Parathion	98-102	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
26101257-1	2015	The HIV-1 restriction factor SAMHD1 is a tetrameric enzyme activated by guanine nucleotides with dNTP triphosphate hydrolase activity (dNTPase).	Guanine Nucleotides	72-91	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	29-35
26294762-3	2015	The anti-HIV-1 activity of SAMHD1 is negatively modulated by phosphorylation at residue Thr-592.	Threonine	88-91	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	27-33
26294762-5	2015	SAMHD1 forms tetramers that possess deoxyribonucleotide triphosphate triphosphohydrolase (dNTPase) activity, which is allosterically controlled by the combined action of GTP and all four dNTPs.	Guanosine Triphosphate	170-173	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
26294762-5	2015	SAMHD1 forms tetramers that possess deoxyribonucleotide triphosphate triphosphohydrolase (dNTPase) activity, which is allosterically controlled by the combined action of GTP and all four dNTPs.	Parathion	187-192	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
26294762-10	2015	These results provide a mechanistic understanding of how SAMHD1 phosphorylation at residue Thr-592 may modulate its cellular and antiviral functions.	Threonine	91-94	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	57-63
26342080-1	2015	The dNTP triphosphohydrolase SAMHD1 is a nuclear antiviral host restriction factor limiting HIV-1 infection in macrophages and a major regulator of dNTP concentrations in human cells.	Parathion	4-8	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	29-35
26342080-1	2015	The dNTP triphosphohydrolase SAMHD1 is a nuclear antiviral host restriction factor limiting HIV-1 infection in macrophages and a major regulator of dNTP concentrations in human cells.	Parathion	148-152	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	29-35
26342080-3	2015	Down-regulation of SAMHD1 by siRNA expands all four dNTP pools, with dGTP undergoing the largest relative increase.	Parathion	52-56	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	19-25
26342080-3	2015	Down-regulation of SAMHD1 by siRNA expands all four dNTP pools, with dGTP undergoing the largest relative increase.	deoxyguanosine triphosphate	69-73	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	19-25
26342080-4	2015	The deoxyguanosine released by SAMHD1 from dGTP can be phosphorylated inside mitochondria by deoxyguanosine kinase (dGK) or degraded in the cytosol by purine nucleoside phosphorylase.	Deoxyguanosine	4-18	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	31-37
26342080-4	2015	The deoxyguanosine released by SAMHD1 from dGTP can be phosphorylated inside mitochondria by deoxyguanosine kinase (dGK) or degraded in the cytosol by purine nucleoside phosphorylase.	deoxyguanosine triphosphate	43-47	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	31-37
26342080-6	2015	We studied if SAMHD1 and dGK interact in the regulation of the dGTP pool during quiescence employing dGK-mutated skin fibroblasts derived from three unrelated patients.	deoxyguanosine triphosphate	63-67	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	14-20
26342080-7	2015	In the presence of SAMHD1 quiescent mutant fibroblasts manifested mt dNTP pool imbalance and mtDNA depletion.	Parathion	69-73	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	19-25
26342080-8	2015	When SAMHD1 was silenced by siRNA transfection the composition of the mt dNTP pool approached that of the controls, and mtDNA copy number increased, compensating the depletion to various degrees in the different mutant fibroblasts.	Parathion	73-77	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	5-11
26342080-11	2015	Our results prove the importance of SAMHD1 in the regulation of all dNTP pools and suggest that dGK inside mitochondria has the function of recycling the deoxyguanosine derived from endogenous dGTP degraded by SAMHD1 in the nucleus.	Parathion	68-72	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	36-42
26342080-11	2015	Our results prove the importance of SAMHD1 in the regulation of all dNTP pools and suggest that dGK inside mitochondria has the function of recycling the deoxyguanosine derived from endogenous dGTP degraded by SAMHD1 in the nucleus.	Deoxyguanosine	154-168	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	210-216
26342080-11	2015	Our results prove the importance of SAMHD1 in the regulation of all dNTP pools and suggest that dGK inside mitochondria has the function of recycling the deoxyguanosine derived from endogenous dGTP degraded by SAMHD1 in the nucleus.	deoxyguanosine triphosphate	193-197	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	36-42
26342080-11	2015	Our results prove the importance of SAMHD1 in the regulation of all dNTP pools and suggest that dGK inside mitochondria has the function of recycling the deoxyguanosine derived from endogenous dGTP degraded by SAMHD1 in the nucleus.	deoxyguanosine triphosphate	193-197	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	210-216
26431200-7	2015	Based on our findings we propose a model for phosphorylation-dependent regulation of SAMHD1 activity where dephosphorylation switches housekeeping SAMHD1 found in cycling cells to a high-activity stable tetrameric form that depletes and maintains low levels of dNTPs in differentiated cells.	Parathion	261-266	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	85-91
26431200-7	2015	Based on our findings we propose a model for phosphorylation-dependent regulation of SAMHD1 activity where dephosphorylation switches housekeeping SAMHD1 found in cycling cells to a high-activity stable tetrameric form that depletes and maintains low levels of dNTPs in differentiated cells.	Parathion	261-266	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	147-153
26416562-5	2015	The discovery of SAMHD1 as the first mammalian dNTP triphosphohydrolase provided new insight into the mechanisms of dNTP regulation.	Parathion	47-51	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	17-23
26416562-6	2015	SAMHD1 maintains the homeostatic dNTP levels that regulate DNA replication and damage repair.	Parathion	33-37	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
26416562-8	2015	Impaired SAMHD1 function can cause increased dNTP pool resulting in genomic instability and cell-cycle progression, thereby facilitating cancer cell proliferation.	Parathion	45-49	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	9-15
26101257-9	2015	An in vivo model is suggested where SAMHD1 alternates between the mutually exclusive functions of ssRNA binding and dNTP hydrolysis depending on dNTP pool levels and the presence of viral ssRNA.	Parathion	116-120	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	36-42
26101257-9	2015	An in vivo model is suggested where SAMHD1 alternates between the mutually exclusive functions of ssRNA binding and dNTP hydrolysis depending on dNTP pool levels and the presence of viral ssRNA.	Parathion	145-149	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	36-42
25926647-2	2015	MDDC are poorly susceptible to HIV-1, in part due to the presence of SAMHD1, a cellular enzyme that depletes intracellular deoxynucleoside triphosphates (dNTPs) and degrades viral RNA.	deoxynucleoside triphosphates	123-152	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	69-75
26045556-8	2015	Furthermore, we show that changing the single Ser-52 in human SAMHD1 to Phe, the residue found in SAMHD1 of Red-capped monkey and Mandrill, allows it to be recognized by Vpx proteins of simian viruses infecting those primate species, which normally does not target wild type human SAMHD1 for degradation.	Serine	46-49	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	62-68
26045556-8	2015	Furthermore, we show that changing the single Ser-52 in human SAMHD1 to Phe, the residue found in SAMHD1 of Red-capped monkey and Mandrill, allows it to be recognized by Vpx proteins of simian viruses infecting those primate species, which normally does not target wild type human SAMHD1 for degradation.	Serine	46-49	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	98-104
26045556-8	2015	Furthermore, we show that changing the single Ser-52 in human SAMHD1 to Phe, the residue found in SAMHD1 of Red-capped monkey and Mandrill, allows it to be recognized by Vpx proteins of simian viruses infecting those primate species, which normally does not target wild type human SAMHD1 for degradation.	Serine	46-49	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	98-104
26045556-8	2015	Furthermore, we show that changing the single Ser-52 in human SAMHD1 to Phe, the residue found in SAMHD1 of Red-capped monkey and Mandrill, allows it to be recognized by Vpx proteins of simian viruses infecting those primate species, which normally does not target wild type human SAMHD1 for degradation.	Phenylalanine	72-75	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	62-68
26045556-8	2015	Furthermore, we show that changing the single Ser-52 in human SAMHD1 to Phe, the residue found in SAMHD1 of Red-capped monkey and Mandrill, allows it to be recognized by Vpx proteins of simian viruses infecting those primate species, which normally does not target wild type human SAMHD1 for degradation.	Phenylalanine	72-75	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	98-104
26045556-8	2015	Furthermore, we show that changing the single Ser-52 in human SAMHD1 to Phe, the residue found in SAMHD1 of Red-capped monkey and Mandrill, allows it to be recognized by Vpx proteins of simian viruses infecting those primate species, which normally does not target wild type human SAMHD1 for degradation.	Phenylalanine	72-75	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	98-104
25926647-2	2015	MDDC are poorly susceptible to HIV-1, in part due to the presence of SAMHD1, a cellular enzyme that depletes intracellular deoxynucleoside triphosphates (dNTPs) and degrades viral RNA.	dntps	154-159	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	69-75
25926647-15	2015	This is due to the presence of SAMHD1, a cellular enzyme that depletes intracellular levels of dNTPs and inhibits viral reverse transcription.	dntps	95-100	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	31-37
26032178-3	2015	The dNTPase function depletes the cellular dNTP pool, which is required for retroviral reverse transcription in differentiated myeloid cells and resting CD4(+) T cells; thus this activity mainly plays a role in SAMHD1-mediated retroviral restriction.	Parathion	4-8	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	211-217
25847232-1	2015	SAMHD1 is a nuclear deoxyribonucleoside triphosphate triphosphohydrolase that contributes to the control of cellular deoxyribonucleoside triphosphate (dNTP) pool sizes through dNTP hydrolysis and modulates the innate immune response to viruses.	deoxyribonucleoside triphosphate	20-52	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
25847232-1	2015	SAMHD1 is a nuclear deoxyribonucleoside triphosphate triphosphohydrolase that contributes to the control of cellular deoxyribonucleoside triphosphate (dNTP) pool sizes through dNTP hydrolysis and modulates the innate immune response to viruses.	Parathion	151-155	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
25847232-5	2015	The effects exerted by Thr-592 phosphorylation-defective SAMHD1 mutants were associated with activation of DNA damage checkpoint and depletion of dNTP concentrations to levels lower than those seen upon expression of wild type SAMHD1 protein.	Parathion	146-150	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	57-63
25847232-1	2015	SAMHD1 is a nuclear deoxyribonucleoside triphosphate triphosphohydrolase that contributes to the control of cellular deoxyribonucleoside triphosphate (dNTP) pool sizes through dNTP hydrolysis and modulates the innate immune response to viruses.	Parathion	176-180	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
25847232-6	2015	These disruptive effects were relieved by either mutation of the catalytic residues of the SAMHD1 phosphohydrolase domain or by a Thr-592 phosphomimetic mutation, thus linking the Thr-592 phosphorylation state to the control of SAMHD1 dNTPase activity.	Threonine	180-183	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	91-97
25847232-2	2015	CyclinA2-CDK1/2 phosphorylates SAMHD1 at Thr-592, but how this modification controls SAMHD1 functions in proliferating cells is not known.	Threonine	41-44	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	31-37
25847232-6	2015	These disruptive effects were relieved by either mutation of the catalytic residues of the SAMHD1 phosphohydrolase domain or by a Thr-592 phosphomimetic mutation, thus linking the Thr-592 phosphorylation state to the control of SAMHD1 dNTPase activity.	Threonine	180-183	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	228-234
25847232-4	2015	Inactivation of the bipartite cyclinA2-CDK-binding site in the SAMHD1 C terminus described herein abolished SAMHD1 phosphorylation on Thr-592 during S and G2 phases thus interfering with DNA replication and progression of cells through S phase.	Threonine	134-137	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	63-69
25847232-7	2015	Our findings support a model in which phosphorylation of Thr-592 by cyclinA2-CDK down-modulates, but does not inactivate, SAMHD1 dNTPase in S phase, thereby fine-tuning SAMHD1 control of dNTP levels during DNA replication.	Threonine	57-60	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	169-175
25847232-4	2015	Inactivation of the bipartite cyclinA2-CDK-binding site in the SAMHD1 C terminus described herein abolished SAMHD1 phosphorylation on Thr-592 during S and G2 phases thus interfering with DNA replication and progression of cells through S phase.	Threonine	134-137	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	108-114
25847232-5	2015	The effects exerted by Thr-592 phosphorylation-defective SAMHD1 mutants were associated with activation of DNA damage checkpoint and depletion of dNTP concentrations to levels lower than those seen upon expression of wild type SAMHD1 protein.	Threonine	23-26	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	57-63
25847232-5	2015	The effects exerted by Thr-592 phosphorylation-defective SAMHD1 mutants were associated with activation of DNA damage checkpoint and depletion of dNTP concentrations to levels lower than those seen upon expression of wild type SAMHD1 protein.	Threonine	23-26	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	227-233
25423367-4	2015	Knowledge of proteins that interact with SAMHD1 may not only enhance our understanding of the pathogenesis of AGS, but may also provide further details on the link between the regulation of cellular dNTPs and HIV-1 restriction.	Parathion	199-204	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	41-47
25760601-0	2015	The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP.	Guanosine Triphosphate	83-86	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	63-69
25760601-1	2015	SAMHD1 is the only known eukaryotic deoxynucleoside triphosphate triphosphohydrolase (dNTPase) and is a major regulator of intracellular dNTP pools.	Parathion	86-90	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
25760601-3	2015	Previous crystal structures have revealed that SAMHD1 is activated by dGTP-dependent tetramer formation.	deoxyguanosine triphosphate	70-74	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	47-53
25760601-4	2015	However, recent data have indicated that the primary activator of SAMHD1 is GTP, not dGTP.	Guanosine Triphosphate	76-79	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	66-72
25760601-4	2015	However, recent data have indicated that the primary activator of SAMHD1 is GTP, not dGTP.	deoxyguanosine triphosphate	85-89	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	66-72
25760601-6	2015	Here, five crystal structures of the catalytic core of SAMHD1 in complex with different combinations of GTP and dNTPs are reported, including a GTP-bound dimer and four GTP/dNTP-bound tetramers.	Guanosine Triphosphate	104-107	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	55-61
25760601-6	2015	Here, five crystal structures of the catalytic core of SAMHD1 in complex with different combinations of GTP and dNTPs are reported, including a GTP-bound dimer and four GTP/dNTP-bound tetramers.	Parathion	112-117	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	55-61
25760601-6	2015	Here, five crystal structures of the catalytic core of SAMHD1 in complex with different combinations of GTP and dNTPs are reported, including a GTP-bound dimer and four GTP/dNTP-bound tetramers.	Guanosine Triphosphate	144-147	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	55-61
25760601-6	2015	Here, five crystal structures of the catalytic core of SAMHD1 in complex with different combinations of GTP and dNTPs are reported, including a GTP-bound dimer and four GTP/dNTP-bound tetramers.	Guanosine Triphosphate	144-147	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	55-61
25760601-6	2015	Here, five crystal structures of the catalytic core of SAMHD1 in complex with different combinations of GTP and dNTPs are reported, including a GTP-bound dimer and four GTP/dNTP-bound tetramers.	Parathion	112-116	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	55-61
25760601-10	2015	In the absence of substrate binding, SAMHD1 adopts an inactive dimer conformation even when complexed with GTP.	Guanosine Triphosphate	107-110	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	37-43
25760601-11	2015	Furthermore, SAMHD1 activation is regulated by the concentration of dNTP.	Parathion	68-72	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	13-19
25760601-12	2015	Thus, the level of dNTP pools is elegantly regulated by the self-sensing ability of SAMHD1 through a novel activation mechanism.	Parathion	19-23	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	84-90
24445253-1	2015	OBJECTIVES: The HIV restriction factor, SAMHD1 (SAM domain and HD domain-containing protein 1), is a triphosphohydrolase that degrades deoxyribonucleoside triphosphates (dNTPs).	deoxyribonucleoside triphosphates	135-168	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	40-46
24445253-1	2015	OBJECTIVES: The HIV restriction factor, SAMHD1 (SAM domain and HD domain-containing protein 1), is a triphosphohydrolase that degrades deoxyribonucleoside triphosphates (dNTPs).	dntps	170-175	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	40-46
24445253-13	2015	CONCLUSIONS: SAMHD1 is required for genome integrity by maintaining balanced dNTP pools.	Parathion	77-81	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	13-19
25449277-1	2014	The function of dNTP hydrolase SAMHD1 as a viral restriction factor to inhibit the replication of several viruses in human immune cells was well established.	Parathion	16-20	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	31-37
25927932-3	2015	SAM domain and HD domain-containing protein 1 (SAMHD1) degrades nucleotide triphosphates and controls the size of the dNTP pool.	nucleotide triphosphates	64-88	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	47-53
25927932-3	2015	SAM domain and HD domain-containing protein 1 (SAMHD1) degrades nucleotide triphosphates and controls the size of the dNTP pool.	Parathion	118-122	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	47-53
25524560-1	2014	BACKGROUND: Host SAM domain and HD domain-containing protein 1 (SAMHD1) suppresses reverse transcription kinetics of HIV-1 in nondividing cells such as macrophages by hydrolyzing and nearly depleting cellular dNTPs, which are the substrates of viral reverse transcriptase (RT).	Parathion	209-214	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	64-70
25524560-2	2014	However, unlike HIV-1, HIV-2 and SIVsm encode viral protein X (Vpx), which counteracts the dNTPase activity of SAMHD1 and elevates dNTP concentration, allowing the viruses to replicate under abundant dNTP conditions even in nondividing cells.	Parathion	91-95	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	111-117
25524560-8	2014	CONCLUSIONS: Our biochemical analysis supports the hypothesis that the enzymological properties, particularly, K m values, of lentivirus RTs, are mechanistically tied with the cellular dNTP availability in nondividing target cells, which is controlled by SAMHD1 and Vpx.	Parathion	185-189	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	255-261
25449277-5	2014	Furthermore, over expression of the SAMHD1 reduces dNTP level and inhibits the proliferation of lung tumor cells.	Parathion	51-55	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	36-42
25267621-0	2014	Structural basis of cellular dNTP regulation by SAMHD1.	Parathion	29-33	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	48-54
25288794-0	2014	Structural basis of allosteric activation of sterile alpha motif and histidine-aspartate domain-containing protein 1 (SAMHD1) by nucleoside triphosphates.	nucleoside triphosphates	129-153	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	45-116
25288794-0	2014	Structural basis of allosteric activation of sterile alpha motif and histidine-aspartate domain-containing protein 1 (SAMHD1) by nucleoside triphosphates.	nucleoside triphosphates	129-153	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	118-124
25288794-1	2014	Sterile alpha motif and histidine-aspartate domain-containing protein 1 (SAMHD1) plays a critical role in inhibiting HIV infection, curtailing the pool of dNTPs available for reverse transcription of the viral genome.	Parathion	155-160	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-71
25288794-1	2014	Sterile alpha motif and histidine-aspartate domain-containing protein 1 (SAMHD1) plays a critical role in inhibiting HIV infection, curtailing the pool of dNTPs available for reverse transcription of the viral genome.	Parathion	155-160	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	73-79
25288794-2	2014	Recent structural data suggested a compelling mechanism for the regulation of SAMHD1 enzymatic activity and revealed dGTP-induced association of two inactive dimers into an active tetrameric enzyme.	deoxyguanosine triphosphate	117-121	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	78-84
25288794-3	2014	Here, we present the crystal structures of SAMHD1 catalytic core (residues 113-626) tetramers, complexed with mixtures of nucleotides, including dGTP/dATP, dGTP/dCTP, dGTP/dTTP, and dGTP/dUTP.	deoxyguanosine triphosphate	145-149	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	43-49
25288794-3	2014	Here, we present the crystal structures of SAMHD1 catalytic core (residues 113-626) tetramers, complexed with mixtures of nucleotides, including dGTP/dATP, dGTP/dCTP, dGTP/dTTP, and dGTP/dUTP.	2'-deoxyadenosine triphosphate	150-154	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	43-49
25288794-3	2014	Here, we present the crystal structures of SAMHD1 catalytic core (residues 113-626) tetramers, complexed with mixtures of nucleotides, including dGTP/dATP, dGTP/dCTP, dGTP/dTTP, and dGTP/dUTP.	thymidine 5'-triphosphate	172-176	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	43-49
25288794-3	2014	Here, we present the crystal structures of SAMHD1 catalytic core (residues 113-626) tetramers, complexed with mixtures of nucleotides, including dGTP/dATP, dGTP/dCTP, dGTP/dTTP, and dGTP/dUTP.	deoxyuridine triphosphate	187-191	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	43-49
25288794-5	2014	In addition, we present biochemical analyses of GTP-induced SAMHD1 full-length tetramerization and the structure of SAMHD1 catalytic core tetramer in complex with GTP/dATP, revealing the structural basis of GTP-mediated SAMHD1 activation.	Guanosine Triphosphate	48-51	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	60-66
25288794-5	2014	In addition, we present biochemical analyses of GTP-induced SAMHD1 full-length tetramerization and the structure of SAMHD1 catalytic core tetramer in complex with GTP/dATP, revealing the structural basis of GTP-mediated SAMHD1 activation.	Guanosine Triphosphate	48-51	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	116-122
25288794-5	2014	In addition, we present biochemical analyses of GTP-induced SAMHD1 full-length tetramerization and the structure of SAMHD1 catalytic core tetramer in complex with GTP/dATP, revealing the structural basis of GTP-mediated SAMHD1 activation.	Guanosine Triphosphate	48-51	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	116-122
25288794-5	2014	In addition, we present biochemical analyses of GTP-induced SAMHD1 full-length tetramerization and the structure of SAMHD1 catalytic core tetramer in complex with GTP/dATP, revealing the structural basis of GTP-mediated SAMHD1 activation.	Guanosine Triphosphate	163-166	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	116-122
25288794-5	2014	In addition, we present biochemical analyses of GTP-induced SAMHD1 full-length tetramerization and the structure of SAMHD1 catalytic core tetramer in complex with GTP/dATP, revealing the structural basis of GTP-mediated SAMHD1 activation.	Guanosine Triphosphate	163-166	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	116-122
25288794-5	2014	In addition, we present biochemical analyses of GTP-induced SAMHD1 full-length tetramerization and the structure of SAMHD1 catalytic core tetramer in complex with GTP/dATP, revealing the structural basis of GTP-mediated SAMHD1 activation.	2'-deoxyadenosine triphosphate	167-171	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	116-122
25288794-5	2014	In addition, we present biochemical analyses of GTP-induced SAMHD1 full-length tetramerization and the structure of SAMHD1 catalytic core tetramer in complex with GTP/dATP, revealing the structural basis of GTP-mediated SAMHD1 activation.	2'-deoxyadenosine triphosphate	167-171	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	116-122
25288794-5	2014	In addition, we present biochemical analyses of GTP-induced SAMHD1 full-length tetramerization and the structure of SAMHD1 catalytic core tetramer in complex with GTP/dATP, revealing the structural basis of GTP-mediated SAMHD1 activation.	Guanosine Triphosphate	163-166	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	116-122
25288794-5	2014	In addition, we present biochemical analyses of GTP-induced SAMHD1 full-length tetramerization and the structure of SAMHD1 catalytic core tetramer in complex with GTP/dATP, revealing the structural basis of GTP-mediated SAMHD1 activation.	Guanosine Triphosphate	163-166	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	116-122
25267621-1	2014	The sterile alpha motif and HD domain-containing protein 1 (SAMHD1), a dNTPase, prevents the infection of nondividing cells by retroviruses, including HIV, by depleting the cellular dNTP pool available for viral reverse transcription.	Parathion	71-75	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	4-58
25267621-1	2014	The sterile alpha motif and HD domain-containing protein 1 (SAMHD1), a dNTPase, prevents the infection of nondividing cells by retroviruses, including HIV, by depleting the cellular dNTP pool available for viral reverse transcription.	Parathion	71-75	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	60-66
25267621-2	2014	SAMHD1 is a major regulator of cellular dNTP levels in mammalian cells.	Parathion	40-44	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
25267621-4	2014	The dNTPase activity of SAMHD1 can be regulated by dGTP, with which SAMHD1 assembles into catalytically active tetramers.	deoxyguanosine triphosphate	51-55	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	24-30
25267621-4	2014	The dNTPase activity of SAMHD1 can be regulated by dGTP, with which SAMHD1 assembles into catalytically active tetramers.	deoxyguanosine triphosphate	51-55	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	68-74
25267621-5	2014	Here we present extensive biochemical and structural data that reveal an exquisite activation mechanism of SAMHD1 via combined action of both GTP and dNTPs.	Guanosine Triphosphate	142-145	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	107-113
25267621-5	2014	Here we present extensive biochemical and structural data that reveal an exquisite activation mechanism of SAMHD1 via combined action of both GTP and dNTPs.	Parathion	150-155	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	107-113
25267621-6	2014	We obtained 26 crystal structures of SAMHD1 in complex with different combinations of GTP and dNTP mixtures, which depict the full spectrum of GTP/dNTP binding at the eight allosteric and four catalytic sites of the SAMHD1 tetramer.	Guanosine Triphosphate	86-89	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	37-43
25267621-6	2014	We obtained 26 crystal structures of SAMHD1 in complex with different combinations of GTP and dNTP mixtures, which depict the full spectrum of GTP/dNTP binding at the eight allosteric and four catalytic sites of the SAMHD1 tetramer.	Parathion	94-98	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	37-43
25267621-6	2014	We obtained 26 crystal structures of SAMHD1 in complex with different combinations of GTP and dNTP mixtures, which depict the full spectrum of GTP/dNTP binding at the eight allosteric and four catalytic sites of the SAMHD1 tetramer.	Parathion	94-98	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	216-222
25267621-6	2014	We obtained 26 crystal structures of SAMHD1 in complex with different combinations of GTP and dNTP mixtures, which depict the full spectrum of GTP/dNTP binding at the eight allosteric and four catalytic sites of the SAMHD1 tetramer.	Guanosine Triphosphate	143-146	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	37-43
25267621-6	2014	We obtained 26 crystal structures of SAMHD1 in complex with different combinations of GTP and dNTP mixtures, which depict the full spectrum of GTP/dNTP binding at the eight allosteric and four catalytic sites of the SAMHD1 tetramer.	Guanosine Triphosphate	143-146	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	216-222
25267621-6	2014	We obtained 26 crystal structures of SAMHD1 in complex with different combinations of GTP and dNTP mixtures, which depict the full spectrum of GTP/dNTP binding at the eight allosteric and four catalytic sites of the SAMHD1 tetramer.	Parathion	147-151	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	37-43
25267621-6	2014	We obtained 26 crystal structures of SAMHD1 in complex with different combinations of GTP and dNTP mixtures, which depict the full spectrum of GTP/dNTP binding at the eight allosteric and four catalytic sites of the SAMHD1 tetramer.	Parathion	147-151	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	216-222
25267621-7	2014	Our data demonstrate how SAMHD1 is activated by binding of GTP or dGTP at allosteric site 1 and a dNTP of any type at allosteric site 2.	Guanosine Triphosphate	59-62	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	25-31
25267621-7	2014	Our data demonstrate how SAMHD1 is activated by binding of GTP or dGTP at allosteric site 1 and a dNTP of any type at allosteric site 2.	deoxyguanosine triphosphate	66-70	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	25-31
25267621-7	2014	Our data demonstrate how SAMHD1 is activated by binding of GTP or dGTP at allosteric site 1 and a dNTP of any type at allosteric site 2.	Parathion	98-102	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	25-31
25267621-8	2014	Our enzymatic assays further reveal a robust regulatory mechanism of SAMHD1 activity, which bares resemblance to that of the ribonuclease reductase responsible for cellular dNTP production.	Parathion	173-177	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	69-75
25267621-9	2014	These results establish a complete framework for a mechanistic understanding of the important functions of SAMHD1 in the regulation of cellular dNTP levels, as well as in HIV restriction and the pathogenesis of CLL and AGS.	Parathion	144-148	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	107-113
25358004-3	2014	The open reading frame of porcine SAMHD1 was cloned into the prokaryotic expression vector pCold-TF DNA to construct a recombinant plasmid pcold-pSAMHD1 and induce expression of recombinant porcine SAMHD1 protein by IPTG in Escherichia coli Rosetta.	Isopropyl Thiogalactoside	216-220	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	34-40
24989684-3	2014	Exome sequencing of the proband"s blood DNA showed a homozygous c.626-1G > C mutation in intron 5 of the SAMHD1 gene, which encodes a triphosphohydrolase involved in the regulation of intracellular dNTP pools and which is mutated in Aicardi-Goutieres syndrome.	Parathion	201-205	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	108-114
25015816-2	2014	Sterile alpha motif and HD domain-containing protein-1 (SAMHD1) is a recently described deoxynucleotide phosphohydrolase controlling the size of the intracellular deoxynucleotide triphosphate (dNTP) pool, a limiting factor for retroviral reverse transcription in noncycling cells.	deoxynucleotide triphosphate	163-191	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-54
25036183-0	2014	Palbociclib, a selective inhibitor of cyclin-dependent kinase4/6, blocks HIV-1 reverse transcription through the control of sterile alpha motif and HD domain-containing protein-1 (SAMHD1) activity.	palbociclib	0-11	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	180-186
25036183-9	2014	RESULTS: Pan-CDK inhibitors AT7519, roscovitine and purvalanol A reduced SAMHD1 phosphorylation.	Roscovitine	36-47	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	73-79
25036183-9	2014	RESULTS: Pan-CDK inhibitors AT7519, roscovitine and purvalanol A reduced SAMHD1 phosphorylation.	purvalanol B	52-62	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	73-79
25158827-0	2014	dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages.	Parathion	0-4	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	33-39
25158827-1	2014	BACKGROUND: SAMHD1 degrades deoxyribonucleotides (dNTPs), suppressing viral DNA synthesis in macrophages.	Deoxyribonucleotides	28-48	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	12-18
25158827-1	2014	BACKGROUND: SAMHD1 degrades deoxyribonucleotides (dNTPs), suppressing viral DNA synthesis in macrophages.	Parathion	50-55	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	12-18
25158827-6	2014	Recovery of SAMHD1 was very slow with less than 3% of the normal macrophage level detected at day 6 post Vpx treatment and only ~30% recovered at day 14.	3vw7	105-108	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	12-18
25158827-13	2014	CONCLUSION: This study reveals that a very low level of SAMHD1 sufficiently modulates the normally low dNTP levels in macrophages and proposes potential diverse mechanisms of Vpx-mediated dNTP regulation in macrophages.	Parathion	103-107	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	56-62
25158827-13	2014	CONCLUSION: This study reveals that a very low level of SAMHD1 sufficiently modulates the normally low dNTP levels in macrophages and proposes potential diverse mechanisms of Vpx-mediated dNTP regulation in macrophages.	Parathion	188-192	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	56-62
25201733-4	2014	MiR-181 level was negatively correlated with SAMHD1 expression level.	mir-181	0-7	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	45-51
25015816-2	2014	Sterile alpha motif and HD domain-containing protein-1 (SAMHD1) is a recently described deoxynucleotide phosphohydrolase controlling the size of the intracellular deoxynucleotide triphosphate (dNTP) pool, a limiting factor for retroviral reverse transcription in noncycling cells.	deoxynucleotide triphosphate	163-191	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	56-62
25015816-2	2014	Sterile alpha motif and HD domain-containing protein-1 (SAMHD1) is a recently described deoxynucleotide phosphohydrolase controlling the size of the intracellular deoxynucleotide triphosphate (dNTP) pool, a limiting factor for retroviral reverse transcription in noncycling cells.	Parathion	193-197	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-54
25015816-2	2014	Sterile alpha motif and HD domain-containing protein-1 (SAMHD1) is a recently described deoxynucleotide phosphohydrolase controlling the size of the intracellular deoxynucleotide triphosphate (dNTP) pool, a limiting factor for retroviral reverse transcription in noncycling cells.	Parathion	193-197	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	56-62
25015816-6	2014	CDK inhibitors specifically blocked HIV-1 infection at the reverse transcription step in a SAMHD1-dependent manner, reducing the intracellular dNTP pool.	Parathion	143-147	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	91-97
25015816-7	2014	Our findings identify a direct relationship between control of the cell cycle by CDK6 and SAMHD1 activity, which is important for replication of lentiviruses, as well as other viruses whose replication may be regulated by intracellular dNTP availability.	Parathion	236-240	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	90-96
24913159-0	2014	SAMHD1 specifically affects the antiviral potency of thymidine analog HIV reverse transcriptase inhibitors.	Thymidine	53-62	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
24867973-1	2014	Sterile alpha motif- and histidine/aspartic acid domain-containing protein 1 (SAMHD1) limits HIV-1 replication by hydrolyzing deoxynucleoside triphosphates (dNTPs) necessary for reverse transcription.	deoxynucleoside triphosphates	126-155	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	78-84
24867973-1	2014	Sterile alpha motif- and histidine/aspartic acid domain-containing protein 1 (SAMHD1) limits HIV-1 replication by hydrolyzing deoxynucleoside triphosphates (dNTPs) necessary for reverse transcription.	dntps	157-162	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	78-84
24913159-1	2014	Sterile alpha motif and histidine-aspartic domain-containing protein 1 (SAMHD1) is a deoxynucleoside triphosphate (dNTP) triphosphohydrolase recently recognized as an antiviral factor that acts by depleting dNTP availability for viral reverse transcriptase (RT).	Parathion	115-119	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-70
24913159-1	2014	Sterile alpha motif and histidine-aspartic domain-containing protein 1 (SAMHD1) is a deoxynucleoside triphosphate (dNTP) triphosphohydrolase recently recognized as an antiviral factor that acts by depleting dNTP availability for viral reverse transcriptase (RT).	Parathion	115-119	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	72-78
24867973-3	2014	We report here that SAMHD1 cleaves NRTI triphosphates (TPs) at significantly lower rates than dNTPs and that SAMHD1 depletion from monocytic cells affects the susceptibility of HIV-1 infections to NRTIs in complex ways that depend not only on the relative changes in dNTP and NRTI-TP concentrations but also on the NRTI activation pathways.	nrti triphosphates	35-53	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	20-26
24913159-2	2014	SAMHD1 restriction is counteracted by the human immunodeficiency virus type 2 (HIV-2) accessory protein Vpx, which targets SAMHD1 for proteosomal degradation, resulting in an increased availability of dNTPs and consequently enhanced viral replication.	Parathion	201-206	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
24867973-3	2014	We report here that SAMHD1 cleaves NRTI triphosphates (TPs) at significantly lower rates than dNTPs and that SAMHD1 depletion from monocytic cells affects the susceptibility of HIV-1 infections to NRTIs in complex ways that depend not only on the relative changes in dNTP and NRTI-TP concentrations but also on the NRTI activation pathways.	triphosphoric acid	55-58	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	20-26
24913159-2	2014	SAMHD1 restriction is counteracted by the human immunodeficiency virus type 2 (HIV-2) accessory protein Vpx, which targets SAMHD1 for proteosomal degradation, resulting in an increased availability of dNTPs and consequently enhanced viral replication.	Parathion	201-206	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	123-129
24867973-3	2014	We report here that SAMHD1 cleaves NRTI triphosphates (TPs) at significantly lower rates than dNTPs and that SAMHD1 depletion from monocytic cells affects the susceptibility of HIV-1 infections to NRTIs in complex ways that depend not only on the relative changes in dNTP and NRTI-TP concentrations but also on the NRTI activation pathways.	triphosphoric acid	55-57	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	20-26
24913159-8	2014	The addition of exogenous thymidine mimicked the change in viral sensitivity observed after Vpx-mediated SAMHD1 degradation, pointing toward a differential effect of SAMHD1 activity on thymidine.	Thymidine	26-35	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	105-111
24913159-8	2014	The addition of exogenous thymidine mimicked the change in viral sensitivity observed after Vpx-mediated SAMHD1 degradation, pointing toward a differential effect of SAMHD1 activity on thymidine.	Thymidine	26-35	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	166-172
24913159-8	2014	The addition of exogenous thymidine mimicked the change in viral sensitivity observed after Vpx-mediated SAMHD1 degradation, pointing toward a differential effect of SAMHD1 activity on thymidine.	Thymidine	185-194	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	166-172
24913159-10	2014	In conclusion, reduction of SAMHD1 levels significantly decreases HIV sensitivity to thymidine but not other nucleotide RT analog inhibitors in both macrophages and lymphocytes.	Thymidine	85-94	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	28-34
25038827-1	2014	The HIV-1 restriction factor SAM domain- and HD domain-containing protein 1 (SAMHD1) is proposed to inhibit HIV-1 replication by depleting the intracellular dNTP pool.	Parathion	157-161	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	77-83
25038827-4	2014	By enzymatically characterizing Aicardi-Goutieres syndrome (AGS)-associated SAMHD1 mutations and mutations in the allosteric dGTP-binding site of SAMHD1 for defects in RNase or dNTPase activity, we identify SAMHD1 point mutants that cause loss of one or both functions.	deoxyguanosine triphosphate	125-129	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	146-152
25038827-4	2014	By enzymatically characterizing Aicardi-Goutieres syndrome (AGS)-associated SAMHD1 mutations and mutations in the allosteric dGTP-binding site of SAMHD1 for defects in RNase or dNTPase activity, we identify SAMHD1 point mutants that cause loss of one or both functions.	deoxyguanosine triphosphate	125-129	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	146-152
24983818-2	2014	We have designed a nonsubstrate dUTP analogue with a methylene bridge connecting the alpha phosphate and 5" carbon that potently inhibits SAMHD1.	Phosphates	91-100	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	138-144
24983818-1	2014	SAMHD1 is a GTP-activated nonspecific dNTP triphosphohydrolase that depletes dNTP pools in resting CD4+ T cells and macrophages and effectively restricts infection by HIV-1.	Guanosine Triphosphate	12-15	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
24983818-2	2014	We have designed a nonsubstrate dUTP analogue with a methylene bridge connecting the alpha phosphate and 5" carbon that potently inhibits SAMHD1.	Carbon	108-114	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	138-144
24983818-1	2014	SAMHD1 is a GTP-activated nonspecific dNTP triphosphohydrolase that depletes dNTP pools in resting CD4+ T cells and macrophages and effectively restricts infection by HIV-1.	Parathion	38-42	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
24828500-1	2014	The deoxyribonucleotide triphosphohydrolase SAMHD1 restricts lentiviral infection by depleting the dNTPs required for viral DNA synthesis.	Parathion	99-104	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	44-50
24983818-2	2014	We have designed a nonsubstrate dUTP analogue with a methylene bridge connecting the alpha phosphate and 5" carbon that potently inhibits SAMHD1.	deoxyuridine triphosphate	32-36	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	138-144
25010268-8	2014	We tested the ability of human SAMHD1 polymorphisms to decrease the dNTP cellular levels.	Parathion	68-72	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	31-37
25010268-9	2014	In agreement, none of the different SAMHD1 variants lost their ability to reduce cellular levels of dNTPs.	Parathion	100-105	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	36-42
24828500-2	2014	In cultured human fibroblasts SAMHD1 is expressed maximally during quiescence preventing accumulation of dNTPs outside S phase.	Parathion	105-110	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	30-36
24828500-3	2014	siRNA silencing of SAMHD1 increases dNTP pools, stops cycling human cells in G1, and blocks DNA replication.	Parathion	36-40	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	19-25
24828500-9	2014	We propose that in quiescent cells where SAMHD1 is maximally expressed GTP binds to site 1 with very high affinity, stabilizing site 2 of the tetrameric structure.	Guanosine Triphosphate	71-74	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	41-47
24828500-10	2014	Any canonical dNTP can bind to site 2 and activate SAMHD1, but in cells only dATP or dTTP are present at sufficient concentrations.	Parathion	14-18	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	51-57
24828500-11	2014	The apparent Km for dATP at site 2 is ~10 mum for mouse and 1 mum for human SAMHD1, for dTTP the corresponding values are 50 and 2 mum.	2'-deoxyadenosine triphosphate	20-24	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	76-82
24828500-11	2014	The apparent Km for dATP at site 2 is ~10 mum for mouse and 1 mum for human SAMHD1, for dTTP the corresponding values are 50 and 2 mum.	thymidine 5'-triphosphate	88-92	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	76-82
24828500-12	2014	Tetrameric SAMHD1 is activated for the hydrolysis of any dNTP only after binding of a dNTP to site 2.	Parathion	57-61	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	11-17
24828500-12	2014	Tetrameric SAMHD1 is activated for the hydrolysis of any dNTP only after binding of a dNTP to site 2.	Parathion	86-90	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	11-17
24828500-13	2014	The lower Km constants for human SAMHD1 induce activation at lower cellular concentrations of dNTPs thereby limiting the size of dNTP pools more efficiently in quiescent human cells.	Parathion	94-99	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	33-39
24828500-13	2014	The lower Km constants for human SAMHD1 induce activation at lower cellular concentrations of dNTPs thereby limiting the size of dNTP pools more efficiently in quiescent human cells.	Parathion	94-98	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	33-39
24719410-9	2014	Here we determined CUL4 requirements for HIV-1 and HIV-2/SIV Vpr-mediated G2 cell cycle arrest, HIV-1 Vpr-mediated UNG2 degradation, and HIV-2 Vpx-mediated SAMHD1 degradation.	cul4	19-23	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	156-162
24623419-2	2014	Phosphorylation of human SAMHD1 at threonine 592 (T592) by cyclin-dependent kinase 1 (CDK1) and cyclin A2 impairs its HIV-1 restriction activity, but not the dNTP hydrolase activity, suggesting that dNTP depletion is not the sole mechanism of SAMHD1-mediated HIV-1 restriction.	Threonine	35-44	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	25-31
24753578-6	2014	The significance of the long-lived activated state is that SAMHD1 can remain active long after dNTP pools have been reduced to a level that would lead to inactivation.	Parathion	95-99	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	59-65
24753578-0	2014	GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state.	Guanosine Triphosphate	0-3	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	62-68
24753578-0	2014	GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state.	Parathion	18-22	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	62-68
24753578-1	2014	The HIV-1 restriction factor sterile alpha-motif/histidine-aspartate domain-containing protein 1 (SAMHD1) is a tetrameric protein that catalyzes the hydrolysis of all dNTPs to the deoxynucleoside and tripolyphosphate, which effectively depletes the dNTP substrates of HIV reverse transcriptase.	Parathion	167-172	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	98-104
24753578-1	2014	The HIV-1 restriction factor sterile alpha-motif/histidine-aspartate domain-containing protein 1 (SAMHD1) is a tetrameric protein that catalyzes the hydrolysis of all dNTPs to the deoxynucleoside and tripolyphosphate, which effectively depletes the dNTP substrates of HIV reverse transcriptase.	deoxynucleoside	180-195	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	98-104
24753578-1	2014	The HIV-1 restriction factor sterile alpha-motif/histidine-aspartate domain-containing protein 1 (SAMHD1) is a tetrameric protein that catalyzes the hydrolysis of all dNTPs to the deoxynucleoside and tripolyphosphate, which effectively depletes the dNTP substrates of HIV reverse transcriptase.	triphosphoric acid	200-216	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	98-104
24753578-1	2014	The HIV-1 restriction factor sterile alpha-motif/histidine-aspartate domain-containing protein 1 (SAMHD1) is a tetrameric protein that catalyzes the hydrolysis of all dNTPs to the deoxynucleoside and tripolyphosphate, which effectively depletes the dNTP substrates of HIV reverse transcriptase.	Parathion	167-171	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	98-104
24753578-2	2014	Here, we establish that SAMHD1 is activated by GTP binding to guanine-specific activator sites (A1) as well as coactivation by substrate dNTP binding to a distinct set of nonspecific activator sites (A2).	Guanosine Triphosphate	47-50	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	24-30
24753578-2	2014	Here, we establish that SAMHD1 is activated by GTP binding to guanine-specific activator sites (A1) as well as coactivation by substrate dNTP binding to a distinct set of nonspecific activator sites (A2).	Guanine	62-69	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	24-30
24753578-2	2014	Here, we establish that SAMHD1 is activated by GTP binding to guanine-specific activator sites (A1) as well as coactivation by substrate dNTP binding to a distinct set of nonspecific activator sites (A2).	Parathion	137-141	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	24-30
24753578-3	2014	Combined activation by GTP and dNTPs results in a long-lived tetrameric form of SAMHD1 that persists for hours, even after activating nucleotides are withdrawn from the solution.	Guanosine Triphosphate	23-26	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	80-86
24753578-3	2014	Combined activation by GTP and dNTPs results in a long-lived tetrameric form of SAMHD1 that persists for hours, even after activating nucleotides are withdrawn from the solution.	Parathion	31-36	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	80-86
24753578-4	2014	These results reveal an ordered model for assembly of SAMHD1 tetramer from its inactive monomer and dimer forms, where GTP binding to the A1 sites generates dimer and dNTP binding to the A2 and catalytic sites generates active tetramer.	Guanosine Triphosphate	119-122	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	54-60
24753578-4	2014	These results reveal an ordered model for assembly of SAMHD1 tetramer from its inactive monomer and dimer forms, where GTP binding to the A1 sites generates dimer and dNTP binding to the A2 and catalytic sites generates active tetramer.	Parathion	167-171	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	54-60
24753578-5	2014	Thus, cellular regulation of active SAMHD1 is not determined by GTP alone but instead, the levels of all dNTPs and the generation of a persistent tetramer that is not in equilibrium with free activators.	Guanosine Triphosphate	64-67	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	36-42
24753578-5	2014	Thus, cellular regulation of active SAMHD1 is not determined by GTP alone but instead, the levels of all dNTPs and the generation of a persistent tetramer that is not in equilibrium with free activators.	Parathion	105-110	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	36-42
24623419-2	2014	Phosphorylation of human SAMHD1 at threonine 592 (T592) by cyclin-dependent kinase 1 (CDK1) and cyclin A2 impairs its HIV-1 restriction activity, but not the dNTP hydrolase activity, suggesting that dNTP depletion is not the sole mechanism of SAMHD1-mediated HIV-1 restriction.	Allura Red AC Dye	50-54	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	25-31
24623419-10	2014	Previous studies suggested that phosphorylation of human SAMHD1 at threonine 592 by CDK1 and cyclin A2 negatively regulates its HIV-1 restriction activity.	Threonine	67-76	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	57-63
23924154-8	2014	SAMHD1 amino acid residue T592, a target of CDK1 phosphorylation, was unphosphorylated, corresponding to the antiviral form of the enzyme.	Allura Red AC Dye	26-30	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
24712655-1	2014	BACKGROUND: The deoxynucleotide-triphosphate (dNTP) hydrolase sterile alpha motif domain and HD domain 1 (SAMHD1) is a nuclear protein that inhibits HIV-1 infection in myeloid cells as well as quiescent CD4 T-cells, by decreasing the intracellular dNTP concentration below a level that is required for efficient reverse transcription.	Parathion	46-50	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	106-112
24712655-8	2014	We also find that VpxMAC-induced SAMHD1 degradation was partially reversed by ubiquitin carrying the K48R or K11R substitution mutations, suggesting involvement of K48 and K11 linkages in SAMHD1 polyubiquitination.	vpxmac	18-24	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	33-39
24712655-8	2014	We also find that VpxMAC-induced SAMHD1 degradation was partially reversed by ubiquitin carrying the K48R or K11R substitution mutations, suggesting involvement of K48 and K11 linkages in SAMHD1 polyubiquitination.	vpxmac	18-24	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	188-194
24317272-7	2014	Following cisplatin treatment and cell cycle analysis, SAMHD1 variants showed different activities in increasing the susceptibility to chemotherapy drugs.	Cisplatin	10-19	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	55-61
24485168-12	2014	CONCLUSION: Inhibition of deoxynucleotide hydrolysis by promoting SAMHD1 degradation is not the only mechanism by which Vpx rescues HIV-1 in MDDCs from the antiviral state.	deoxynucleotide	26-41	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	66-72
24161438-2	2013	SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase that degrades the intracellular pool of deoxynucleoside triphosphates available during early reverse transcription.	deoxynucleoside triphosphates	101-130	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
24352659-4	2014	Terminally differentiated/nondividing macrophages, which serve as a key HIV-1 reservoir, contain extremely low dNTP concentrations (20-50 nm), which results from the cellular dNTP hydrolyzing sterile alpha motif and histidine aspartic domain containing protein 1 (SAMHD1) protein, when compared with activated CD4(+) T cells (2-5 mum).	Parathion	111-115	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	264-270
24352659-4	2014	Terminally differentiated/nondividing macrophages, which serve as a key HIV-1 reservoir, contain extremely low dNTP concentrations (20-50 nm), which results from the cellular dNTP hydrolyzing sterile alpha motif and histidine aspartic domain containing protein 1 (SAMHD1) protein, when compared with activated CD4(+) T cells (2-5 mum).	Parathion	175-179	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	264-270
24352659-6	2014	Second, SAMHD1 degradation by viral protein X (Vpx), which elevates cellular dNTP concentrations, decreased HIV-1 template switching efficiency in macrophages to the levels comparable with CD4(+) T cells.	Parathion	77-81	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	8-14
24352659-10	2014	Here, we report that SAMHD1 regulation of the dNTP concentrations influences HIV-1 template switching efficiency, particularly in macrophages.	Parathion	46-50	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	21-27
24336198-2	2014	One such restriction factor, SAMHD1, inhibits human immunodeficiency virus (HIV)-1 infection of myeloid-lineage cells as well as resting CD4(+) T cells by reducing the cellular deoxynucleoside 5"-triphosphate (dNTP) concentration to a level at which the viral reverse transcriptase cannot function.	Parathion	177-208	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	29-35
24336198-2	2014	One such restriction factor, SAMHD1, inhibits human immunodeficiency virus (HIV)-1 infection of myeloid-lineage cells as well as resting CD4(+) T cells by reducing the cellular deoxynucleoside 5"-triphosphate (dNTP) concentration to a level at which the viral reverse transcriptase cannot function.	Parathion	210-214	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	29-35
24155378-0	2014	A first-in-class NAE inhibitor, MLN4924, blocks lentiviral infection in myeloid cells by disrupting neddylation-dependent Vpx-mediated SAMHD1 degradation.	N-lauroylethanolamine	17-20	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	135-141
24139400-3	2013	Investigating the monocyte depletion observed during HTLV-1 infection, we discovered that primary human monocytes infected with HTLV-1 undergo abortive infection accompanied by apoptosis dependent on SAMHD1, a host restriction factor that hydrolyzes endogenous dNTPs to below the levels required for productive reverse transcription.	Parathion	261-266	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	200-206
24067963-11	2013	HSV-1 restriction involved the dNTP triphosphohydrolase activity of SAMHD1 and was partially overcome by addition of exogenous deoxynucleosides.	deoxynucleosides	127-143	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	68-74
24257155-1	2013	The host dNTP hydrolase SAMHD1 acts as a viral restriction factor to inhibit the replication of several retroviruses and DNA viruses in non-cycling human immune cells.	Parathion	9-13	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	24-30
24257155-4	2013	Both studies suggest that SAMHD1 is important for regulating the intracellular dNTP pool and the intrinsic immunity against retroviral infection, despite different outcomes of HIV-1 vector transduction in these mouse models.	Parathion	79-83	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	26-32
24219908-6	2013	In agreement with these observations, the Y146S/Y154S variant of a bacterial construct expressing the HD domain of human SAMHD1 (residues 109-626) disrupted the dGTP-dependent tetramerization of SAMHD1 in vitro.	deoxyguanosine triphosphate	161-165	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	121-127
24219908-6	2013	In agreement with these observations, the Y146S/Y154S variant of a bacterial construct expressing the HD domain of human SAMHD1 (residues 109-626) disrupted the dGTP-dependent tetramerization of SAMHD1 in vitro.	deoxyguanosine triphosphate	161-165	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	195-201
23966382-3	2013	It has been proposed that SAMHD1 is a dGTP-dependent deoxynucleoside triphosphohydrolase (dNTPase) that restricts HIV-1 by reducing cellular dNTP levels to below that required for reverse transcription.	deoxyguanosine triphosphate	38-42	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	26-32
23966382-3	2013	It has been proposed that SAMHD1 is a dGTP-dependent deoxynucleoside triphosphohydrolase (dNTPase) that restricts HIV-1 by reducing cellular dNTP levels to below that required for reverse transcription.	Parathion	90-94	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	26-32
23986575-3	2013	SAMHD1 is thought to work by depleting the pool of intracellular deoxynucleoside triphosphates but has also been reported to have exonuclease activity that could allow it to degrade the viral genomic RNA or viral reverse-transcribed DNA.	deoxynucleoside triphosphates	65-94	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
23986575-9	2013	Similarly, Vpx-containing virus-like particles and deoxynucleosides added to the cells more than 24 h postinfection released the SAMHD1-mediated block.	deoxynucleosides	51-67	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	129-135
24141705-0	2013	Mechanism of allosteric activation of SAMHD1 by dGTP.	deoxyguanosine triphosphate	48-52	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	38-44
24141705-3	2013	The inactive apo-SAMHD1 interconverts between monomers and dimers, and in the presence of dGTP the protein assembles into catalytically active tetramers.	deoxyguanosine triphosphate	90-94	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	17-23
24141705-4	2013	Here, we present the crystal structure of the human tetrameric SAMHD1-dGTP complex.	deoxyguanosine triphosphate	70-74	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	63-69
23880768-4	2013	However, we now demonstrate biochemically that the NTP GTP is equally capable of activating SAMHD1, but GTP is not hydrolyzed by the enzyme.	ntp gtp	51-58	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	92-98
23880768-0	2013	GTP is the primary activator of the anti-HIV restriction factor SAMHD1.	Guanosine Triphosphate	0-3	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	64-70
23872947-3	2013	SAMHD1 is a triphosphohydrolase that depletes the cellular pool of deoxynucleoside triphosphates, thereby preventing reverse transcription of retroviral genomes.	deoxynucleoside triphosphates	67-96	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
23872947-6	2013	Samhd1(-/-) cells have elevated deoxynucleoside triphosphate (dNTP) levels but, surprisingly, SAMHD1 deficiency did not lead to increased infection with VSV-G-pseudotyped HIV-1 vectors.	deoxynucleoside triphosphate	32-60	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
23872947-6	2013	Samhd1(-/-) cells have elevated deoxynucleoside triphosphate (dNTP) levels but, surprisingly, SAMHD1 deficiency did not lead to increased infection with VSV-G-pseudotyped HIV-1 vectors.	Parathion	62-66	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
23872947-8	2013	Consistent with this notion, an HIV-1 vector mutant bearing an RT with lower affinity for dNTPs was sensitive to SAMHD1-dependent restriction in cultured cells and in mice.	Parathion	90-95	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	113-119
23972988-4	2013	Human SAMHD1 is an HIV-1 restriction factor that hydrolyzes dNTPs and decreases their concentration below the levels required for retroviral reverse transcription.	Parathion	60-65	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	6-12
23880768-1	2013	SAMHD1 (SAM domain- and HD domain-containing protein 1) is a dGTP-dependent dNTP triphosphohydrolase that converts dNTPs into deoxyribonucleosides and triphosphates.	deoxyguanosine triphosphate	61-65	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
23880768-1	2013	SAMHD1 (SAM domain- and HD domain-containing protein 1) is a dGTP-dependent dNTP triphosphohydrolase that converts dNTPs into deoxyribonucleosides and triphosphates.	deoxyguanosine triphosphate	61-65	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	8-54
23880768-4	2013	However, we now demonstrate biochemically that the NTP GTP is equally capable of activating SAMHD1, but GTP is not hydrolyzed by the enzyme.	Guanosine Triphosphate	55-58	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	92-98
23880768-1	2013	SAMHD1 (SAM domain- and HD domain-containing protein 1) is a dGTP-dependent dNTP triphosphohydrolase that converts dNTPs into deoxyribonucleosides and triphosphates.	Parathion	115-120	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
23880768-1	2013	SAMHD1 (SAM domain- and HD domain-containing protein 1) is a dGTP-dependent dNTP triphosphohydrolase that converts dNTPs into deoxyribonucleosides and triphosphates.	Parathion	115-120	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	8-54
23880768-5	2013	Activation of SAMHD1 phosphohydrolase activity was tested under physiological concentrations of dGTP or GTP found in either dividing or non-dividing cells.	deoxyguanosine triphosphate	96-100	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	14-20
23880768-5	2013	Activation of SAMHD1 phosphohydrolase activity was tested under physiological concentrations of dGTP or GTP found in either dividing or non-dividing cells.	Guanosine Triphosphate	97-100	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	14-20
23880768-1	2013	SAMHD1 (SAM domain- and HD domain-containing protein 1) is a dGTP-dependent dNTP triphosphohydrolase that converts dNTPs into deoxyribonucleosides and triphosphates.	Deoxyribonucleosides	126-146	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
23880768-1	2013	SAMHD1 (SAM domain- and HD domain-containing protein 1) is a dGTP-dependent dNTP triphosphohydrolase that converts dNTPs into deoxyribonucleosides and triphosphates.	Deoxyribonucleosides	126-146	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	8-54
23880768-6	2013	Because GTP is 1000-fold more abundant than dGTP in cells, GTP was able to activate the enzyme to a greater extent than dGTP, suggesting that GTP is the primary activator of SAMHD1.	Guanosine Triphosphate	8-11	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	174-180
23880768-1	2013	SAMHD1 (SAM domain- and HD domain-containing protein 1) is a dGTP-dependent dNTP triphosphohydrolase that converts dNTPs into deoxyribonucleosides and triphosphates.	triphosphoric acid	151-164	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
23880768-6	2013	Because GTP is 1000-fold more abundant than dGTP in cells, GTP was able to activate the enzyme to a greater extent than dGTP, suggesting that GTP is the primary activator of SAMHD1.	Guanosine Triphosphate	45-48	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	174-180
23880768-1	2013	SAMHD1 (SAM domain- and HD domain-containing protein 1) is a dGTP-dependent dNTP triphosphohydrolase that converts dNTPs into deoxyribonucleosides and triphosphates.	triphosphoric acid	151-164	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	8-54
23880768-6	2013	Because GTP is 1000-fold more abundant than dGTP in cells, GTP was able to activate the enzyme to a greater extent than dGTP, suggesting that GTP is the primary activator of SAMHD1.	deoxyguanosine triphosphate	120-124	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	174-180
23880768-2	2013	Therefore, SAMHD1 expression, particularly in non-dividing cells, can restrict retroviral infections such as HIV and simian immunodeficiency virus by limiting cellular dNTPs, which are essential for reverse transcription.	Parathion	168-173	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	11-17
23880768-3	2013	It has previously been established that dGTP acts as both an activator and a substrate of this enzyme, suggesting that phosphohydrolase activity of SAMHD1 is regulated by dGTP availability in the cell.	deoxyguanosine triphosphate	40-44	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	148-154
23880768-6	2013	Because GTP is 1000-fold more abundant than dGTP in cells, GTP was able to activate the enzyme to a greater extent than dGTP, suggesting that GTP is the primary activator of SAMHD1.	Guanosine Triphosphate	45-48	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	174-180
23880768-3	2013	It has previously been established that dGTP acts as both an activator and a substrate of this enzyme, suggesting that phosphohydrolase activity of SAMHD1 is regulated by dGTP availability in the cell.	deoxyguanosine triphosphate	171-175	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	148-154
23880768-7	2013	Finally, we show that SAMHD1 has the ability to hydrolyze base-modified nucleotides, indicating that the active site of SAMHD1 is not restrictive to such modifications, and is capable of regulating the levels of non-canonical dNTPs such as dUTP.	Parathion	226-231	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	22-28
23880768-7	2013	Finally, we show that SAMHD1 has the ability to hydrolyze base-modified nucleotides, indicating that the active site of SAMHD1 is not restrictive to such modifications, and is capable of regulating the levels of non-canonical dNTPs such as dUTP.	Parathion	226-231	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	120-126
23880768-7	2013	Finally, we show that SAMHD1 has the ability to hydrolyze base-modified nucleotides, indicating that the active site of SAMHD1 is not restrictive to such modifications, and is capable of regulating the levels of non-canonical dNTPs such as dUTP.	deoxyuridine triphosphate	240-244	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	22-28
23880768-7	2013	Finally, we show that SAMHD1 has the ability to hydrolyze base-modified nucleotides, indicating that the active site of SAMHD1 is not restrictive to such modifications, and is capable of regulating the levels of non-canonical dNTPs such as dUTP.	deoxyuridine triphosphate	240-244	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	120-126
23744077-0	2013	Anti-HIV host factor SAMHD1 regulates viral sensitivity to nucleoside reverse transcriptase inhibitors via modulation of cellular deoxyribonucleoside triphosphate (dNTP) levels.	deoxyribonucleoside triphosphate	130-162	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	21-27
23858451-1	2013	Sterile alpha motif and HD-domain containing protein 1 (SAMHD1) is a triphosphohydrolase converting deoxynucleoside triphosphates (dNTPs) to deoxynucleosides.	deoxynucleoside triphosphates	100-129	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	56-62
23858451-1	2013	Sterile alpha motif and HD-domain containing protein 1 (SAMHD1) is a triphosphohydrolase converting deoxynucleoside triphosphates (dNTPs) to deoxynucleosides.	dntps	131-136	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	56-62
23858451-1	2013	Sterile alpha motif and HD-domain containing protein 1 (SAMHD1) is a triphosphohydrolase converting deoxynucleoside triphosphates (dNTPs) to deoxynucleosides.	deoxynucleosides	141-157	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	56-62
23858451-4	2013	Here we identify a general function of SAMHD1 in the regulation of dNTP pools in cultured human cells.	Parathion	67-71	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	39-45
23858451-6	2013	Treatment of lung or skin fibroblasts with specific siRNAs resulted in the disappearence of SAMHD1 accompanied by loss of the cell-cycle regulation of dNTP pool sizes and dNTP imbalance.	Parathion	151-155	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	92-98
23858451-6	2013	Treatment of lung or skin fibroblasts with specific siRNAs resulted in the disappearence of SAMHD1 accompanied by loss of the cell-cycle regulation of dNTP pool sizes and dNTP imbalance.	Parathion	171-175	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	92-98
23858451-9	2013	In quiescent cultures SAMHD1 down-regulation leads to a marked expansion of dNTP pools.	Parathion	76-80	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	22-28
23858451-10	2013	In all cases the largest effect was on dGTP, the preferred substrate of SAMHD1.	deoxyguanosine triphosphate	39-43	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	72-78
23858451-13	2013	Synthesis by the reductase peaks during S-phase, and catabolism by SAMHD1 is maximal during G1 phase when large dNTP pools would prevent cells from preparing for a new round of DNA replication.	Parathion	112-116	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	67-73
23744077-0	2013	Anti-HIV host factor SAMHD1 regulates viral sensitivity to nucleoside reverse transcriptase inhibitors via modulation of cellular deoxyribonucleoside triphosphate (dNTP) levels.	Parathion	164-168	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	21-27
23744077-1	2013	Newly identified anti-HIV host factor, SAMHD1, restricts replication of lentiviruses such as HIV-1, HIV-2, and simian immunodeficiency virus in macrophages by enzymatically hydrolyzing and depleting cellular dNTPs, which are the substrates of viral DNA polymerases.	Parathion	208-213	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	39-45
23744077-4	2013	We found that reduction of SAMHD1 levels with the use of virus-like particles expressing Vpx- and SAMHD1-specific shRNA subsequently elevates cellular dNTPs and significantly decreases HIV-1 sensitivity to various NRTIs in macrophages.	Parathion	151-156	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	27-33
23744077-4	2013	We found that reduction of SAMHD1 levels with the use of virus-like particles expressing Vpx- and SAMHD1-specific shRNA subsequently elevates cellular dNTPs and significantly decreases HIV-1 sensitivity to various NRTIs in macrophages.	Parathion	151-156	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	98-104
23744077-6	2013	Furthermore, with the use of HPLC, we could not detect SAMHD1-mediated hydrolysis of NRTI-triphosphates, verifying that the reduced sensitivity of HIV-1 to NRTIs upon SAMHD1 degradation is most likely caused by the elevation in cellular dNTPs.	Parathion	237-242	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	167-173
23497255-2	2013	In macrophages and dendritic cells, SAMHD1 restricts virus replication by diminishing the deoxynucleotide triphosphate pool to a level below that which supports lentiviral reverse transcription.	deoxynucleotide triphosphate	90-118	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	36-42
23371319-1	2013	SAM domain and HD domain-containing protein 1 (SAMHD1) is a dGTP-dependent triphosphohydrolase that degrades deoxyribonucleoside triphosphates (dNTPs) thereby limiting the intracellular dNTP pool.	deoxyguanosine triphosphate	60-64	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-45
23371319-1	2013	SAM domain and HD domain-containing protein 1 (SAMHD1) is a dGTP-dependent triphosphohydrolase that degrades deoxyribonucleoside triphosphates (dNTPs) thereby limiting the intracellular dNTP pool.	deoxyguanosine triphosphate	60-64	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	47-53
23371319-1	2013	SAM domain and HD domain-containing protein 1 (SAMHD1) is a dGTP-dependent triphosphohydrolase that degrades deoxyribonucleoside triphosphates (dNTPs) thereby limiting the intracellular dNTP pool.	deoxyribonucleoside triphosphates	109-142	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-45
23371319-1	2013	SAM domain and HD domain-containing protein 1 (SAMHD1) is a dGTP-dependent triphosphohydrolase that degrades deoxyribonucleoside triphosphates (dNTPs) thereby limiting the intracellular dNTP pool.	deoxyribonucleoside triphosphates	109-142	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	47-53
23371319-1	2013	SAM domain and HD domain-containing protein 1 (SAMHD1) is a dGTP-dependent triphosphohydrolase that degrades deoxyribonucleoside triphosphates (dNTPs) thereby limiting the intracellular dNTP pool.	dntps	144-149	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-45
23371319-1	2013	SAM domain and HD domain-containing protein 1 (SAMHD1) is a dGTP-dependent triphosphohydrolase that degrades deoxyribonucleoside triphosphates (dNTPs) thereby limiting the intracellular dNTP pool.	dntps	144-149	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	47-53
23371319-1	2013	SAM domain and HD domain-containing protein 1 (SAMHD1) is a dGTP-dependent triphosphohydrolase that degrades deoxyribonucleoside triphosphates (dNTPs) thereby limiting the intracellular dNTP pool.	Parathion	144-148	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-45
23371319-1	2013	SAM domain and HD domain-containing protein 1 (SAMHD1) is a dGTP-dependent triphosphohydrolase that degrades deoxyribonucleoside triphosphates (dNTPs) thereby limiting the intracellular dNTP pool.	Parathion	144-148	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	47-53
23564003-6	2013	The conversion of ATP to adenosine inhibits HIV-specific effector cells and the hydrolysis of dNTPs by SAMHD1 restricts infection.	Parathion	94-99	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	103-109
23601106-1	2013	SAMHD1 is a cellular enzyme that depletes intracellular deoxynucleoside triphosphates (dNTPs) and inhibits the ability of retroviruses, notably HIV-1, to infect myeloid cells.	deoxynucleoside triphosphates	56-85	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
23601106-1	2013	SAMHD1 is a cellular enzyme that depletes intracellular deoxynucleoside triphosphates (dNTPs) and inhibits the ability of retroviruses, notably HIV-1, to infect myeloid cells.	dntps	87-92	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
23601106-3	2013	We determined that SAMHD1 is phosphorylated on residue T592 in cycling cells but that this phosphorylation is lost when cells are in a noncycling state.	Allura Red AC Dye	55-59	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	19-25
23426366-1	2013	SAMHD1 is a dGTP-activated dNTPase that has been implicated as a modulator of the innate immune response.	deoxyguanosine triphosphate	12-16	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
23426366-7	2013	Accordingly, we show that the C terminus is required for the full ability of SAMHD1 to deplete dNTP pools and to inhibit HIV-1 infection in U937 monocytes.	Parathion	95-99	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	77-83
23364794-3	2013	Here, we show that the purified full-length human SAMHD1 protein also possesses metal-dependent 3" 5" exonuclease activity against single-stranded DNAs and RNAs in vitro.	Metals	80-85	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	50-56
23497353-3	2013	SAMHD1 depletes dNTP levels in myeloid cells below those required for optimal synthesis of HIV viral DNA.	Parathion	16-20	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
23677995-1	2013	SAMHD1, a dGTP-regulated deoxyribonucleoside triphosphate (dNTP) triphosphohydrolase, down-regulates dNTP pools in terminally differentiated and quiescent cells, thereby inhibiting HIV-1 infection at the reverse transcription step.	deoxyguanosine triphosphate	10-14	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
23677995-1	2013	SAMHD1, a dGTP-regulated deoxyribonucleoside triphosphate (dNTP) triphosphohydrolase, down-regulates dNTP pools in terminally differentiated and quiescent cells, thereby inhibiting HIV-1 infection at the reverse transcription step.	Parathion	59-63	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
23677995-7	2013	Further, we provide evidence that Vpx binding to SAMHD1 inhibits its catalytic activity and induces disassembly of a dGTP-dependent oligomer.	deoxyguanosine triphosphate	117-121	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	49-55
23602554-4	2013	Cyclin A2/CDK1 phosphorylates SAMHD1 at the Threonine 592 residue both in vitro and in vivo.	Threonine	44-53	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	30-36
23269793-2	2013	SAMHD1 depletes the intracellular pool of deoxynucleoside triphosphates, thus impairing HIV-1 reverse transcription and productive infection in noncycling cells.	deoxynucleoside triphosphates	42-71	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
23260109-4	2013	Indeed, a recently discovered anti-HIV/SIV restriction factor, SAMHD1, which is a dNTP triphosphohydrolase, is responsible for the limited dNTP pool of nondividing cells.	Parathion	82-86	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	63-69
23442224-2	2013	Sterile alpha motif and HD domain protein 1 (SAMHD1), a dGTP-regulated deoxynucleotide triphosphohydrolase, reduces HIV-1 infectivity in myeloid cells, likely by limiting dNTPs available for reverse transcription, and has been described as IFNalpha-inducible.	deoxyguanosine triphosphate	56-60	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	45-51
23442224-2	2013	Sterile alpha motif and HD domain protein 1 (SAMHD1), a dGTP-regulated deoxynucleotide triphosphohydrolase, reduces HIV-1 infectivity in myeloid cells, likely by limiting dNTPs available for reverse transcription, and has been described as IFNalpha-inducible.	Parathion	171-176	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	45-51
23260109-6	2013	Interestingly, Vpx of HIV-2/SIVsm proteosomally degrades SAMHD1, which elevates cellular dNTP pools and accelerates lentiviral replication in nondividing cells.	Parathion	89-93	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	57-63
23231760-8	2012	CONCLUSIONS: Our results suggest that SAMHD1-mediated reduction of the intracellular dNTP pool in DCs is a common mechanism of HIV-1 restriction in myeloid cells.	Parathion	85-89	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	38-44
23231760-0	2012	SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons.	Parathion	61-65	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
24217394-0	2013	Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase.	deoxyguanosine triphosphate	24-28	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	64-70
24217394-1	2013	SAMHD1 is a dGTP-activated deoxynucleoside triphosphate triphosphohydrolase (dNTPase) whose dNTPase activity has been linked to HIV/SIV restriction.	deoxyguanosine triphosphate	12-16	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
24217394-4	2013	Here we report the 1.8-A crystal structure of homotetrameric SAMHD1 in complex with the allosteric activator and substrate dGTP/dATP.	deoxyguanosine triphosphate	123-127	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	61-67
24217394-4	2013	Here we report the 1.8-A crystal structure of homotetrameric SAMHD1 in complex with the allosteric activator and substrate dGTP/dATP.	2'-deoxyadenosine triphosphate	128-132	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	61-67
24217394-6	2013	Allosteric dGTP binding induces conformational changes at the active site, allowing a more stable interaction with the substrate and explaining the dGTP-induced SAMHD1 dNTPase activity.	deoxyguanosine triphosphate	11-15	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	161-167
24217394-6	2013	Allosteric dGTP binding induces conformational changes at the active site, allowing a more stable interaction with the substrate and explaining the dGTP-induced SAMHD1 dNTPase activity.	deoxyguanosine triphosphate	148-152	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	161-167
24217394-8	2013	dGTP-triggered tetramer formation is also important for SAMHD1-mediated LINE-1 regulation.	deoxyguanosine triphosphate	0-4	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	56-62
23825958-1	2013	SAMHD1 is a newly identified anti-HIV host factor that has a dNTP triphosphohydrolase activity and depletes intracellular dNTP pools in non-dividing myeloid cells.	Parathion	61-65	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
23825958-3	2013	Indeed, two double stranded DNA viruses, vaccinia and herpes simplex virus type 1, are subject to SAMHD1 restriction in non-dividing target cells in a dNTP dependent manner.	Parathion	151-155	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	98-104
23231760-2	2012	Acting as a deoxynucleoside triphosphate (dNTP) triphosphohydrolase, SAMHD1 hydrolyzes dNTPs and restricts HIV-1 infection in macrophages and resting CD4+ T-cells by decreasing the intracellular dNTP pool.	Parathion	87-92	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	69-75
23231760-2	2012	Acting as a deoxynucleoside triphosphate (dNTP) triphosphohydrolase, SAMHD1 hydrolyzes dNTPs and restricts HIV-1 infection in macrophages and resting CD4+ T-cells by decreasing the intracellular dNTP pool.	Parathion	42-46	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	69-75
23062609-4	2012	Vpx induces the degradation of SAMHD1, a nucleotide triphosphohydrolase that blocks lentiviral reverse transcription in myeloid cells via depletion of the intracellular pool of dNTPs.	Parathion	177-182	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	31-37
23231760-3	2012	However, the intracellular dNTP pool in DCs and its regulation by SAMHD1 remain unclear.	Parathion	27-31	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	66-72
23231760-5	2012	RESULTS: Here, we report that SAMHD1 significantly blocked single-cycle and replication-competent HIV-1 infection of DCs by decreasing the intracellular dNTP pool and thereby limiting the accumulation of HIV-1 late reverse transcription products.	Parathion	153-157	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	30-36
23231760-7	2012	When SAMHD1 was over-expressed in these two cell lines to achieve higher levels than that in DCs, no HIV-1 restriction was observed despite partially reducing the intracellular dNTP pool.	Parathion	177-181	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	5-11
22926205-3	2012	SAMHD1 limits viral replication through an original mechanism: it hydrolyses intracellular dNTPs in non-cycling cells, thus decreasing the amount of these key substrates, which are required for viral DNA synthesis.	Parathion	91-96	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
22973040-1	2012	Sterile alpha motif domain- and HD domain-containing protein 1 (SAMHD1) is a deoxynucleoside triphosphohydrolase that restricts the replication of lentiviruses in myeloid cells by hydrolyzing the cellular deoxynucleotide triphosphates to a level below that which is required for reverse transcription.	deoxynucleotide triphosphates	205-234	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-62
22973040-1	2012	Sterile alpha motif domain- and HD domain-containing protein 1 (SAMHD1) is a deoxynucleoside triphosphohydrolase that restricts the replication of lentiviruses in myeloid cells by hydrolyzing the cellular deoxynucleotide triphosphates to a level below that which is required for reverse transcription.	deoxynucleotide triphosphates	205-234	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	64-70
23135508-2	2012	A new study shows that host deoxynucleoside triphosphate triphosphohydrolase (dNTPase) sterile alpha motif and histidine/aspartic domain-containing protein 1 (SAMHD1), previously shown to block HIV infection in myeloid cells, also restricts HIV replication in resting CD4(+) T cells by hydrolyzing dNTPs, which are needed for reverse transcription of the virus (pages 1682-1687).	Parathion	298-303	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	87-157
23135508-2	2012	A new study shows that host deoxynucleoside triphosphate triphosphohydrolase (dNTPase) sterile alpha motif and histidine/aspartic domain-containing protein 1 (SAMHD1), previously shown to block HIV infection in myeloid cells, also restricts HIV replication in resting CD4(+) T cells by hydrolyzing dNTPs, which are needed for reverse transcription of the virus (pages 1682-1687).	Parathion	298-303	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	159-165
23092512-2	2012	SAMHD1 is a dNTPase that presumably reduces the cellular dNTP levels to levels too low for retroviral reverse transcription to occur.	Parathion	12-16	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
22978176-3	2012	The early studies have focused on its gene mutations associated with Aicardi-Goutieres syndrome (AGS), the latest study found that SAMHD1 as a potent dGTP-stimulated triphosphohydrolase restricts HIV-1 replication by hydrolyzing the majority of cellular dNTPs, thus inhibiting reverse transcription and viral complementary DNA (cDNA) synthesis.	deoxyguanosine triphosphate	150-154	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	131-137
22908011-7	2012	Studies have since revealed that SAMHD1 degrades deoxynucleoside triphosphates (dNTPs), which are components of viral genomic cDNA, in order to deprive viruses of dNTPs.	deoxynucleoside triphosphates	49-78	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	33-39
22908011-7	2012	Studies have since revealed that SAMHD1 degrades deoxynucleoside triphosphates (dNTPs), which are components of viral genomic cDNA, in order to deprive viruses of dNTPs.	dntps	80-85	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	33-39
22908011-7	2012	Studies have since revealed that SAMHD1 degrades deoxynucleoside triphosphates (dNTPs), which are components of viral genomic cDNA, in order to deprive viruses of dNTPs.	dntps	163-168	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	33-39
22978176-3	2012	The early studies have focused on its gene mutations associated with Aicardi-Goutieres syndrome (AGS), the latest study found that SAMHD1 as a potent dGTP-stimulated triphosphohydrolase restricts HIV-1 replication by hydrolyzing the majority of cellular dNTPs, thus inhibiting reverse transcription and viral complementary DNA (cDNA) synthesis.	Parathion	254-259	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	131-137
22341459-2	2012	Two papers in this issue of Cell Host & Microbe document the genetic conflict between SAMHD1 and the Vpr/Vpx proteins, which has subjected SAMHD1 to intense periods of diversifying selection through primate evolution.	Adenosine Monophosphate	39-42	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	90-96
22341459-2	2012	Two papers in this issue of Cell Host & Microbe document the genetic conflict between SAMHD1 and the Vpr/Vpx proteins, which has subjected SAMHD1 to intense periods of diversifying selection through primate evolution.	Adenosine Monophosphate	39-42	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	143-149
22069334-0	2011	Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase.	deoxyguanosine triphosphate	73-77	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	61-67
22327569-2	2012	Here we found that SAMHD1 restricted infection by hydrolyzing intracellular deoxynucleoside triphosphates (dNTPs), lowering their concentrations to below those required for the synthesis of the viral DNA by reverse transcriptase (RT).	deoxynucleoside triphosphates	76-105	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	19-25
22327569-2	2012	Here we found that SAMHD1 restricted infection by hydrolyzing intracellular deoxynucleoside triphosphates (dNTPs), lowering their concentrations to below those required for the synthesis of the viral DNA by reverse transcriptase (RT).	dntps	107-112	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	19-25
22327569-3	2012	SAMHD1-mediated restriction was alleviated by the addition of exogenous deoxynucleosides.	deoxynucleosides	72-88	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
22327569-5	2012	Vpx prevented the SAMHD1-mediated decrease in dNTP concentration and induced the degradation of human and rhesus macaque SAMHD1 but had no effect on mouse SAMHD1.	Parathion	46-50	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	18-24
22069334-4	2011	We show that SAMHD1 contains a dGTP-regulated deoxynucleotide triphosphohydrolase.	deoxyguanosine triphosphate	31-35	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	13-19
22069334-5	2011	We propose that Vpx targets SAMHD1 for degradation in a viral strategy to control cellular deoxynucleotide levels for efficient replication.	deoxynucleotide	91-106	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	28-34
22056990-5	2011	Here we show that human SAMHD1 is a potent dGTP-stimulated triphosphohydrolase that converts deoxynucleoside triphosphates to the constituent deoxynucleoside and inorganic triphosphate.	deoxyguanosine triphosphate	43-47	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	24-30
22056990-5	2011	Here we show that human SAMHD1 is a potent dGTP-stimulated triphosphohydrolase that converts deoxynucleoside triphosphates to the constituent deoxynucleoside and inorganic triphosphate.	deoxynucleoside triphosphates	93-122	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	24-30
22056990-5	2011	Here we show that human SAMHD1 is a potent dGTP-stimulated triphosphohydrolase that converts deoxynucleoside triphosphates to the constituent deoxynucleoside and inorganic triphosphate.	deoxynucleoside	93-108	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	24-30
22056990-5	2011	Here we show that human SAMHD1 is a potent dGTP-stimulated triphosphohydrolase that converts deoxynucleoside triphosphates to the constituent deoxynucleoside and inorganic triphosphate.	triphosphoric acid	162-184	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	24-30
22056990-6	2011	The crystal structure of the catalytic core of SAMHD1 reveals that the protein is dimeric and indicates a molecular basis for dGTP stimulation of catalytic activity against dNTPs.	deoxyguanosine triphosphate	126-130	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	47-53
22056990-6	2011	The crystal structure of the catalytic core of SAMHD1 reveals that the protein is dimeric and indicates a molecular basis for dGTP stimulation of catalytic activity against dNTPs.	Parathion	173-178	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	47-53
22056990-7	2011	We propose that SAMHD1, which is highly expressed in dendritic cells, restricts HIV-1 replication by hydrolysing the majority of cellular dNTPs, thus inhibiting reverse transcription and viral complementary DNA (cDNA) synthesis.	Parathion	138-143	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	16-22
20842748-5	2010	Next generation sequencing of the entire region identified the c.490C>T (p.Arg164X) mutationin SAMHD1, a gene most recently described in AGS, on both alleles in all affected siblings.Clinical diagnosis of AGS was then confirmed by demonstrating intracerebral calcifications on cranial computed tomography in all siblings and elevated pterin levels in CSF in three of them.	Pterins	337-343	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	98-104