PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33648539-12	2021	Specifically, SIRT7 is shown to interact with the CRL4-DCAF1 complex, and expression of Vpr in HEK293T cells results in SIRT7 degradation, which is partially rescued by CRL inhibitor MNL4924 and proteasome inhibitor MG132.	mnl4924	183-190	sirtuin 7	Homo sapiens	14-19
33749979-5	2021	Moreover, SIRT7 interacts with KCC4 in a NAD+ -dependent manner and increases its stability and activity in HEK293 cells.	NAD	41-45	sirtuin 7	Homo sapiens	10-15
33738675-4	2021	In mammals, sirtuin family comprises seven members (SIRT1-SIRT7), and they all possess a conserved NAD+ binding catalytic domain, termed the sirtuin core domain which is imperative for their activity.	NAD	99-103	sirtuin 7	Homo sapiens	58-63
33838133-7	2021	In general, there were two pathways confirmed using tissues and cells: 1) Increased histone deacetylase sirtuin 7 (SIRT7) mediated loss of histone 3 lysine 18 acetylation (H3K18ac) at the promoter of OAT2 and inhibited its transcription.	Lysine	149-155	sirtuin 7	Homo sapiens	115-120
33648539-12	2021	Specifically, SIRT7 is shown to interact with the CRL4-DCAF1 complex, and expression of Vpr in HEK293T cells results in SIRT7 degradation, which is partially rescued by CRL inhibitor MNL4924 and proteasome inhibitor MG132.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	216-221	sirtuin 7	Homo sapiens	14-19
32403131-1	2021	CONTEXT: The sirtuins (SIRT1 to SIRT7) constitute a family of highly conserved nicotinamide adenine dinucleotide-dependent proteins.	NAD	79-112	sirtuin 7	Homo sapiens	32-37
33440786-4	2021	In this review, we provide an overview of the current knowledge of NAD+ metabolism, highlighting the functional liaison with mono(ADP-ribosyl)ating enzymes, such as the well-known ARTD10 (also named PARP10), SIRT6, and SIRT7.	NAD	67-71	sirtuin 7	Homo sapiens	219-224
32861997-1	2020	SIRT7 is a member of the mammalian sirtuins and functions as an NAD+-dependent deacylase.	NAD	64-67	sirtuin 7	Homo sapiens	0-5
31843644-0	2020	Biochemical characterization of mono ADP ribosyl transferase activity of human sirtuin SIRT7 and its regulation.	poly(ADP)-ribosylated proteins	37-48	sirtuin 7	Homo sapiens	87-92
32586688-1	2020	Sirtuin 7 (SIRT7) is a NAD+ (nicotinamide adenine dinucleotide) dependent deacetylase that is reported to contribute to tumour growth and invasion by selectively acting on histone H3K18.	NAD	23-26	sirtuin 7	Homo sapiens	0-9
32586688-1	2020	Sirtuin 7 (SIRT7) is a NAD+ (nicotinamide adenine dinucleotide) dependent deacetylase that is reported to contribute to tumour growth and invasion by selectively acting on histone H3K18.	NAD	23-26	sirtuin 7	Homo sapiens	11-16
32586688-1	2020	Sirtuin 7 (SIRT7) is a NAD+ (nicotinamide adenine dinucleotide) dependent deacetylase that is reported to contribute to tumour growth and invasion by selectively acting on histone H3K18.	NAD	29-62	sirtuin 7	Homo sapiens	0-9
32586688-1	2020	Sirtuin 7 (SIRT7) is a NAD+ (nicotinamide adenine dinucleotide) dependent deacetylase that is reported to contribute to tumour growth and invasion by selectively acting on histone H3K18.	NAD	29-62	sirtuin 7	Homo sapiens	11-16
32586688-10	2020	In addition, the ratio of apoptotic cells following sorafenib treatment was significantly higher in SIRT7 knockdown cells than control cells (p=0.040), implying that SIRT7 knockdown potentiated the effect of sorafenib.	Sorafenib	52-61	sirtuin 7	Homo sapiens	100-105
32586688-10	2020	In addition, the ratio of apoptotic cells following sorafenib treatment was significantly higher in SIRT7 knockdown cells than control cells (p=0.040), implying that SIRT7 knockdown potentiated the effect of sorafenib.	Sorafenib	208-217	sirtuin 7	Homo sapiens	100-105
32586688-10	2020	In addition, the ratio of apoptotic cells following sorafenib treatment was significantly higher in SIRT7 knockdown cells than control cells (p=0.040), implying that SIRT7 knockdown potentiated the effect of sorafenib.	Sorafenib	208-217	sirtuin 7	Homo sapiens	166-171
32586688-12	2020	In addition, our in vitro model showed that SIRT7 knockdown was associated with reduced proliferation, and suggested abrogation of SIRT7 may potentiate the effect of sorafenib.	Sorafenib	166-175	sirtuin 7	Homo sapiens	44-49
32586688-12	2020	In addition, our in vitro model showed that SIRT7 knockdown was associated with reduced proliferation, and suggested abrogation of SIRT7 may potentiate the effect of sorafenib.	Sorafenib	166-175	sirtuin 7	Homo sapiens	131-136
31970414-1	2020	NAD+-dependent SIRT7 deacylase plays essential roles in ribosome biogenesis, stress response, genome integrity, metabolism and aging, while how it is transcriptionally regulated is still largely unclear.	NAD	0-3	sirtuin 7	Homo sapiens	15-20
32519817-4	2020	We further demonstrated that the NAD-dependent protein deacetylase, SIRT7, and the FOXO4 transcription factor acted as endogenous brakes for GLS1 expression, which are inhibited by TGF-beta.	NAD	33-36	sirtuin 7	Homo sapiens	68-73
32527012-3	2020	STRAP is acetylated at lysines 147, 148, and 156 by the acetyltransferases CREB-binding protein (CBP) and that the acetylation is reversed by the deacetylase sirtuin7 (SIRT7).	Lysine	23-30	sirtuin 7	Homo sapiens	158-166
31025603-1	2020	The sirtuin family comprises seven NAD+-dependent histone deacetylases named SIRT1 to SIRT7.	NAD	35-39	sirtuin 7	Homo sapiens	86-91
31025603-9	2020	Preferred orientations of NAD+ and acetyl-lysine inside SIRT7 were found, with all components forming a stable complex.	NAD	26-30	sirtuin 7	Homo sapiens	56-61
31025603-9	2020	Preferred orientations of NAD+ and acetyl-lysine inside SIRT7 were found, with all components forming a stable complex.	N(alpha)-acetyllysine	35-48	sirtuin 7	Homo sapiens	56-61
31843644-3	2020	SIRT7 contains a conserved catalytic core with long flanking N- and C-terminal extensions.	Nitrogen	61-62	sirtuin 7	Homo sapiens	0-5
31843644-3	2020	SIRT7 contains a conserved catalytic core with long flanking N- and C-terminal extensions.	Carbon	68-69	sirtuin 7	Homo sapiens	0-5
31843644-6	2020	Mutation of certain residues at the active site suggests that mono ADP-ribosylation and deacetylation are two distinct activities of SIRT7.	Adenosine Diphosphate	67-70	sirtuin 7	Homo sapiens	133-138
31843644-7	2020	In this study, we also find that the SIRT7 enzyme can specifically transfer a single moiety of ADP ribose on other nuclear proteins, with a preference for NAD+.	Adenosine Diphosphate Ribose	95-105	sirtuin 7	Homo sapiens	37-42
31843644-7	2020	In this study, we also find that the SIRT7 enzyme can specifically transfer a single moiety of ADP ribose on other nuclear proteins, with a preference for NAD+.	NAD	155-158	sirtuin 7	Homo sapiens	37-42
31843644-10	2020	A comparison of these dual activities suggests SIRT7"s preference for the mono ADPr transfer over its deacetylation of H3K18Ac.	H-2K(K) antigen	119-126	sirtuin 7	Homo sapiens	47-52
31843644-14	2020	Finally, we can also relate SIRT7 to the DNA repair process through ADP ribosylation of one of its key players, PARP1.	Adenosine Diphosphate	68-71	sirtuin 7	Homo sapiens	28-33
32019578-0	2020	SIRT7 depletion inhibits cell proliferation and androgen-induced autophagy by suppressing the AR signaling in prostate cancer.	Androgens	48-56	sirtuin 7	Homo sapiens	0-5
32019578-12	2020	RESULTS: SIRT7 depletion significantly inhibited cell proliferation, androgen-induced autophagy, and invasion in LNCap and 22Rv1 cells (in vitro) and mouse xenograft tumors induced by injection of these cells (in vivo).	Androgens	69-77	sirtuin 7	Homo sapiens	9-14
30756531-1	2019	As a member of the Sirtuins family in mammals, SIRT7 locates in nucleus and is a highly specific H3K18Ac (acetylated lysine 18 of histone H3) deacetylase.	Lysine	117-123	sirtuin 7	Homo sapiens	47-52
31848116-1	2020	Sirtuins (SIRT1-SIRT7) are an evolutionary conserved family of NAD+-dependent protein deacylases regulating the acylation state of epsilon-N-lysine residues of proteins thereby controlling key biological processes.	epsilon-n-lysine	131-147	sirtuin 7	Homo sapiens	16-21
31785216-2	2019	PURPOSE: SIR proteins (silent information regulators, sirtuins, SIRT1 - SIRT7, SIR1 - SIR7) belong to NAD+-dependent deacetylases, enzymes taking part in a catalytic reaction of deacetylation, i.e. splitting the rest of acetic acid from protein substrates.	Acetic Acid	220-231	sirtuin 7	Homo sapiens	72-77
31075303-1	2019	Sirtuin 7 (SIRT7) is an NAD+-dependent lysine deacetylase that regulates diverse biological processes.	NAD	24-27	sirtuin 7	Homo sapiens	0-9
31075303-1	2019	Sirtuin 7 (SIRT7) is an NAD+-dependent lysine deacetylase that regulates diverse biological processes.	NAD	24-27	sirtuin 7	Homo sapiens	11-16
31196136-3	2019	METHODS: Expression of SIRT7 in 17 paired paraffin-embedded HCC tissues and adjacent nontumoral liver tissues was examined by immunohistochemistry and Western blot.	Paraffin	42-50	sirtuin 7	Homo sapiens	23-28
31196136-8	2019	Depletion of SIRT7 from multiple liver cancer cell lines significantly increased doxorubicin toxicity while overexpression of SIRT7 largely abolished doxorubicin induced apoptosis.	Doxorubicin	81-92	sirtuin 7	Homo sapiens	13-18
31196136-8	2019	Depletion of SIRT7 from multiple liver cancer cell lines significantly increased doxorubicin toxicity while overexpression of SIRT7 largely abolished doxorubicin induced apoptosis.	Doxorubicin	150-161	sirtuin 7	Homo sapiens	126-131
31196136-9	2019	At the molecular level, we observed that SIRT7 interacts with and induces deacetylation of p53 at lysines 320 and 373.	Lysine	98-105	sirtuin 7	Homo sapiens	41-46
31158122-2	2019	The current study was undertaken to investigate the role of sirtuin family members (SIRT1-SIRT7) on the anti-inflammation activities of resveratrol in endothelial cells.	Resveratrol	136-147	sirtuin 7	Homo sapiens	90-95
31158122-9	2019	SIRT1, SIRT2, SIRT5, and SIRT7 gene expression could be upregulated by pretreatment with resveratrol compared with TNF-alpha alone while there were no obvious differences of SIRT3, SIRT4, and SIRT6 expressions observed in TNF-alpha alone treated cells and resveratrol-TNF-alpha co-treated cells.	Resveratrol	89-100	sirtuin 7	Homo sapiens	25-30
31906251-9	2019	Related to clinical parameters SIRT1, SIRT6 and SIRT7 correlate positively with FSH and LH doses administered in EM patients.	Luteinizing Hormone	88-90	sirtuin 7	Homo sapiens	48-53
30453040-3	2019	As a family of NAD+ dependent protein modifying enzymes, sirtuins (SIRT1-SIRT7) have multiple catalytic functions such as deacetylase, desuccinylase, demalonylase, demyristoylase, depalmitoylase, and/or mono-ADP-ribosyltransferase.	NAD	15-18	sirtuin 7	Homo sapiens	73-78
31206100-7	2019	H2AQ104 methylation and chromatin dynamics are regulated by fibrillarin (FBL) and the NAD+-dependent nucleolar deacetylase sirtuin 7 (SIRT7).	h2aq104	0-7	sirtuin 7	Homo sapiens	123-132
31206100-7	2019	H2AQ104 methylation and chromatin dynamics are regulated by fibrillarin (FBL) and the NAD+-dependent nucleolar deacetylase sirtuin 7 (SIRT7).	h2aq104	0-7	sirtuin 7	Homo sapiens	134-139
31206100-7	2019	H2AQ104 methylation and chromatin dynamics are regulated by fibrillarin (FBL) and the NAD+-dependent nucleolar deacetylase sirtuin 7 (SIRT7).	NAD	86-90	sirtuin 7	Homo sapiens	123-132
31206100-7	2019	H2AQ104 methylation and chromatin dynamics are regulated by fibrillarin (FBL) and the NAD+-dependent nucleolar deacetylase sirtuin 7 (SIRT7).	NAD	86-90	sirtuin 7	Homo sapiens	134-139
30578034-0	2019	Cyclic tripeptide-based potent human SIRT7 inhibitors.	cyclic tripeptide	0-17	sirtuin 7	Homo sapiens	37-42
30578034-1	2019	In the current study, two cyclic tripeptides respectively harboring a thiourea-type and a carboxamide-type of catalytic mechanism-based sirtuin inhibitory warheads as the central residue were found to behave as potent (low muM level) inhibitors against the tRNA-activated human SIRT7 deacetylase activity.	cyclic tripeptides	26-44	sirtuin 7	Homo sapiens	278-283
30282801-3	2018	Using co-expression in HEK293T cells and co-immunoprecipitation assays, we observed that SIRT7 deacetylates WDR77 at Lys-3 and Lys-243, which reduced of WDR77"s interaction with PRMT5.	Lysine	117-120	sirtuin 7	Homo sapiens	89-94
30540930-5	2018	SIRT7-dependent deacetylation of FBL ensures H2AQ104me and high levels of rRNA synthesis during interphase.	h2aq104me	45-54	sirtuin 7	Homo sapiens	0-5
30559718-9	2018	In the opposite, SIRT4 and SIRT7 inhibit insulin secretion and fatty acid oxidation.	Fatty Acids	63-73	sirtuin 7	Homo sapiens	27-32
30655851-1	2019	Sirtuin-7 is an evolutionarily conserved NAD-dependent deacetylase, which serves an important role in carcinogenesis.	NAD	41-44	sirtuin 7	Homo sapiens	0-9
30655851-8	2019	The knockdown of sirtuin-7 was observed to increase the sensitivity of the endometrial cancer cells to cisplatin treatment in vitro.	Cisplatin	103-112	sirtuin 7	Homo sapiens	17-26
30348528-0	2018	Depletion of SIRT7 sensitizes human non-small cell lung cancer cells to gemcitabine therapy by inhibiting autophagy.	gemcitabine	72-83	sirtuin 7	Homo sapiens	13-18
30348528-4	2018	In our study, we find that SIRT7 protein level elevated dramatically in response to an anti-metabolic drug-gemcitabine treatment.	gemcitabine	107-118	sirtuin 7	Homo sapiens	27-32
30348528-5	2018	Moreover, autophagy induced by gemcitabine in non-small cell lung cancer cells is SIRT7-dependent.	gemcitabine	31-42	sirtuin 7	Homo sapiens	82-87
30348528-6	2018	Furthermore, depletion of SIRT7 promoted Gemcitabine-induced cell death.	gemcitabine	41-52	sirtuin 7	Homo sapiens	26-31
30282801-3	2018	Using co-expression in HEK293T cells and co-immunoprecipitation assays, we observed that SIRT7 deacetylates WDR77 at Lys-3 and Lys-243, which reduced of WDR77"s interaction with PRMT5.	Lysine	127-130	sirtuin 7	Homo sapiens	89-94
30093732-7	2018	Additionally, the persistent exposure of diabetic cells to high glucose concentrations (25 mM) promoted the upregulation of caveolin-1, N-cadherin, SIRT3, SIRT7 and lactate levels, suggesting that long-term diabetes may promote cell proliferation.	Glucose	64-71	sirtuin 7	Homo sapiens	155-160
30282801-6	2018	In summary, SIRT7 is a major deacetylase for WDR77, and SIRT7-mediated deacetylation of WDR77 at Lys-3 and Lys-243 weakens the WDR77-PRMT5 interaction and activity and thereby suppresses growth of cancer cells.	Lysine	97-100	sirtuin 7	Homo sapiens	12-17
30282801-6	2018	In summary, SIRT7 is a major deacetylase for WDR77, and SIRT7-mediated deacetylation of WDR77 at Lys-3 and Lys-243 weakens the WDR77-PRMT5 interaction and activity and thereby suppresses growth of cancer cells.	Lysine	97-100	sirtuin 7	Homo sapiens	56-61
30282801-6	2018	In summary, SIRT7 is a major deacetylase for WDR77, and SIRT7-mediated deacetylation of WDR77 at Lys-3 and Lys-243 weakens the WDR77-PRMT5 interaction and activity and thereby suppresses growth of cancer cells.	Lysine	107-110	sirtuin 7	Homo sapiens	12-17
30282801-6	2018	In summary, SIRT7 is a major deacetylase for WDR77, and SIRT7-mediated deacetylation of WDR77 at Lys-3 and Lys-243 weakens the WDR77-PRMT5 interaction and activity and thereby suppresses growth of cancer cells.	Lysine	107-110	sirtuin 7	Homo sapiens	56-61
29231244-7	2018	Meanwhile, SIRT7 depletion can increase the sensitivity of breast cancer cells to doxorubicin (DOX).	Doxorubicin	82-93	sirtuin 7	Homo sapiens	11-16
29231244-7	2018	Meanwhile, SIRT7 depletion can increase the sensitivity of breast cancer cells to doxorubicin (DOX).	Doxorubicin	95-98	sirtuin 7	Homo sapiens	11-16
29231244-8	2018	Xenograft model studies showed that stable silencing of SIRT7 inhibited tumor growth and enhanced tumor sensitivity to DOX.	Doxorubicin	119-122	sirtuin 7	Homo sapiens	56-61
29231244-10	2018	Taken together, our results showed that SIRT7 plays a critical role in breast cancer cell survival, migration, and tumor growth, and increased the efficiency of DOX treatment both in vitro and in vivo.	Doxorubicin	161-164	sirtuin 7	Homo sapiens	40-45
30090057-1	2018	Sirtuin enzymes are a family of highly seven conserved protein deacetylases, namely SIRT1 through SIRT7, whose enzymatic activities require the cofactor nicotinamide adenine dinucleotide (NAD+).	NAD	153-186	sirtuin 7	Homo sapiens	98-103
30090057-1	2018	Sirtuin enzymes are a family of highly seven conserved protein deacetylases, namely SIRT1 through SIRT7, whose enzymatic activities require the cofactor nicotinamide adenine dinucleotide (NAD+).	NAD	188-192	sirtuin 7	Homo sapiens	98-103
28886238-6	2017	Following inhibition of nucleolar function by actinomycin D or 5-fluorouracil treatment or knocking down the gene for the RNA polymerase I component UBF, SIRT7 is mobilized from the nucleolus to the nucleoplasm and promotes DDB1 deacetylation, leading to decreased DDB1-CUL4 association and CRL4 activity.	Dactinomycin	46-59	sirtuin 7	Homo sapiens	154-159
29305011-3	2018	Recent findings have identified critical roles for SIRT1 and SIRT7 in glucose/lipid metabolism in multiple tissues.	Glucose	70-77	sirtuin 7	Homo sapiens	61-66
29710664-8	2018	The binding relationship between miR-340 and the SIRT7 3"-untranslated region was verified by dual-luciferase reporter assay.	mir-340	33-40	sirtuin 7	Homo sapiens	49-54
29710664-11	2018	Notably, the overexpression of SIRT7 promoted the proliferation and invasion of angiosarcoma cells and also partially reversed the antitumor effect of miR-340 on angiosarcoma cell proliferation and invasion.	mir-340	151-158	sirtuin 7	Homo sapiens	31-36
29710664-12	2018	Taken together, our results demonstrate that miR-340 inhibits the growth and invasion of angiosarcoma cells by targeting SIRT7.	mir-340	45-52	sirtuin 7	Homo sapiens	121-126
29879377-1	2018	SIRT7, a member of the sirtuin family, with coenzyme NAD catalyzes protein deacetylation and has been implicated in multiple biologic processes; however, its function in mammalian oocytes remains to be explored.	NAD	53-56	sirtuin 7	Homo sapiens	0-5
29888767-6	2018	We additionally demonstrate that defective TCA cycle metabolism results in a DNA repair defect and sensitivity to genotoxic agents, consistent with previously reported chromatin hypersuccinylation effects observed in the context of SIRT7 depletion.	Tricarboxylic Acids	43-46	sirtuin 7	Homo sapiens	232-237
28675767-0	2017	Sirtuin7 is involved in protecting neurons against oxygen-glucose deprivation and reoxygenation-induced injury through regulation of the p53 signaling pathway.	Oxygen	51-57	sirtuin 7	Homo sapiens	0-8
28886238-6	2017	Following inhibition of nucleolar function by actinomycin D or 5-fluorouracil treatment or knocking down the gene for the RNA polymerase I component UBF, SIRT7 is mobilized from the nucleolus to the nucleoplasm and promotes DDB1 deacetylation, leading to decreased DDB1-CUL4 association and CRL4 activity.	Fluorouracil	63-77	sirtuin 7	Homo sapiens	154-159
28675767-3	2017	In this study, we aimed to investigate the potential role of SIRT7 in regulating oxygen-glucose deprivation and reoxygenation (OGD/R)-induced injury in neurons.	Oxygen	81-87	sirtuin 7	Homo sapiens	61-66
28849008-0	2017	microRNA-20b contributes to high glucose-induced podocyte apoptosis by targeting SIRT7.	Glucose	33-40	sirtuin 7	Homo sapiens	81-86
27882448-1	2017	Sirtuins (SIRT1-SIRT7) are unique histone deacetylases (HDACs) whose activity depends on NAD+ levels and thus on the cellular metabolic status.	NAD	89-93	sirtuin 7	Homo sapiens	16-21
28772218-10	2017	The silencing of SIRT7 markedly abrogated the protective effect induced by miR-142-5p suppression.	mir-142-5p	75-85	sirtuin 7	Homo sapiens	17-22
28772218-11	2017	Taken together, these results suggest that downregulation of miR-142-5p alleviates hypoxia-induced injury through upregulation of SIRT7.	mir-142-5p	61-71	sirtuin 7	Homo sapiens	130-135
28435470-0	2017	Downregulation of SIRT7 by 5-fluorouracil induces radiosensitivity in human colorectal cancer.	Fluorouracil	27-41	sirtuin 7	Homo sapiens	18-23
28435470-2	2017	Here, we report that NAD+-dependent deacetylase sirtuin-7 (SIRT7) protein levels were decreased due to 5-FU exposure rendering colorectal cancer cells sensitive to radiation.	Fluorouracil	103-107	sirtuin 7	Homo sapiens	21-57
28435470-2	2017	Here, we report that NAD+-dependent deacetylase sirtuin-7 (SIRT7) protein levels were decreased due to 5-FU exposure rendering colorectal cancer cells sensitive to radiation.	Fluorouracil	103-107	sirtuin 7	Homo sapiens	59-64
28435470-4	2017	Specifically, TBP1 was dephosphorylated at tyrosine 381 upon 5-FU treatment, which enhanced its direct interaction with SIRT7 and targeted it for degradation.	Tyrosine	43-51	sirtuin 7	Homo sapiens	120-125
28435470-6	2017	Interestingly, decreased levels of SIRT7 mediated by 5-FU correlated well with improved therapeutic effect in patients with rectal cancer and with inhibited tumor growth in immune-compromised mice post-irradiation.	Fluorouracil	53-57	sirtuin 7	Homo sapiens	35-40
28435470-7	2017	Taken together, these data suggest that 5-FU induces radiosensitivity via SIRT7 degradation to favor a cell death pathway in targeted cancer cells.	Fluorouracil	40-44	sirtuin 7	Homo sapiens	74-79
28426094-6	2017	Mechanistically, SIRT7 promotes the release of P-TEFb from the inactive 7SK snRNP complex and deacetylates CDK9, a subunit of the elongation factor P-TEFb, which activates transcription by phosphorylating serine 2 within the C-terminal domain (CTD) of Pol II.	7sk snrnp	72-81	sirtuin 7	Homo sapiens	17-22
29100388-7	2017	Finally, we also showed that SIRT7 overexpression induced the resistance to docetaxel.	Docetaxel	76-85	sirtuin 7	Homo sapiens	29-34
28827661-6	2017	Significantly, resveratrol activates SIRT7 deacetylase activity, inhibits breast cancer lung metastases, and increases survival.	Resveratrol	15-26	sirtuin 7	Homo sapiens	37-42
28655758-1	2017	Sirtuin 7 (SIRT7), a member of the NAD+-dependent class III histone deacetylases, is involved in the regulation of various cellular processes and in resisting various stresses, such as hypoxia, low glucose levels, and DNA damage.	NAD	35-39	sirtuin 7	Homo sapiens	0-9
28655758-1	2017	Sirtuin 7 (SIRT7), a member of the NAD+-dependent class III histone deacetylases, is involved in the regulation of various cellular processes and in resisting various stresses, such as hypoxia, low glucose levels, and DNA damage.	NAD	35-39	sirtuin 7	Homo sapiens	11-16
28655758-1	2017	Sirtuin 7 (SIRT7), a member of the NAD+-dependent class III histone deacetylases, is involved in the regulation of various cellular processes and in resisting various stresses, such as hypoxia, low glucose levels, and DNA damage.	Glucose	198-205	sirtuin 7	Homo sapiens	0-9
28655758-1	2017	Sirtuin 7 (SIRT7), a member of the NAD+-dependent class III histone deacetylases, is involved in the regulation of various cellular processes and in resisting various stresses, such as hypoxia, low glucose levels, and DNA damage.	Glucose	198-205	sirtuin 7	Homo sapiens	11-16
28655758-7	2017	We showed that USP7 interacts with SIRT7 both in vitro and in vivo, and we further demonstrated that SIRT7 undergoes endogenous Lys-63-linked polyubiquitination, which is removed by USP7.	Lysine	128-131	sirtuin 7	Homo sapiens	35-40
28655758-7	2017	We showed that USP7 interacts with SIRT7 both in vitro and in vivo, and we further demonstrated that SIRT7 undergoes endogenous Lys-63-linked polyubiquitination, which is removed by USP7.	Lysine	128-131	sirtuin 7	Homo sapiens	101-106
28426094-6	2017	Mechanistically, SIRT7 promotes the release of P-TEFb from the inactive 7SK snRNP complex and deacetylates CDK9, a subunit of the elongation factor P-TEFb, which activates transcription by phosphorylating serine 2 within the C-terminal domain (CTD) of Pol II.	serine 2	205-213	sirtuin 7	Homo sapiens	17-22
28426094-7	2017	SIRT7 counteracts GCN5-directed acetylation of lysine 48 within the catalytic domain of CDK9, deacetylation promoting CTD phosphorylation and transcription elongation.	Lysine	47-53	sirtuin 7	Homo sapiens	0-5
27498548-1	2016	BACKGROUND: SIRT7 is one of the histone deacetylases and is NAD-dependent.	NAD	60-63	sirtuin 7	Homo sapiens	12-17
27997115-6	2017	Here, we show that RNA can increase the catalytic efficiency of SIRT7 even better and that SIRT7 can remove long chain fatty acyl groups more efficiently than removing acetyl groups.	long chain fatty acyl groups	108-136	sirtuin 7	Homo sapiens	64-69
27997115-6	2017	Here, we show that RNA can increase the catalytic efficiency of SIRT7 even better and that SIRT7 can remove long chain fatty acyl groups more efficiently than removing acetyl groups.	long chain fatty acyl groups	108-136	sirtuin 7	Homo sapiens	91-96
27997115-10	2017	Knockdown of SIRT7 increased the lysine fatty acylation of several nuclear proteins based on metabolic labeling with an alkyne-tagged fatty acid analog, supporting that the defatty-acylase activity of SIRT7 is physiologically relevant.	Lysine	33-39	sirtuin 7	Homo sapiens	13-18
27997115-10	2017	Knockdown of SIRT7 increased the lysine fatty acylation of several nuclear proteins based on metabolic labeling with an alkyne-tagged fatty acid analog, supporting that the defatty-acylase activity of SIRT7 is physiologically relevant.	Lysine	33-39	sirtuin 7	Homo sapiens	201-206
27997115-10	2017	Knockdown of SIRT7 increased the lysine fatty acylation of several nuclear proteins based on metabolic labeling with an alkyne-tagged fatty acid analog, supporting that the defatty-acylase activity of SIRT7 is physiologically relevant.	Alkynes	120-126	sirtuin 7	Homo sapiens	13-18
27997115-10	2017	Knockdown of SIRT7 increased the lysine fatty acylation of several nuclear proteins based on metabolic labeling with an alkyne-tagged fatty acid analog, supporting that the defatty-acylase activity of SIRT7 is physiologically relevant.	Alkynes	120-126	sirtuin 7	Homo sapiens	201-206
27997115-10	2017	Knockdown of SIRT7 increased the lysine fatty acylation of several nuclear proteins based on metabolic labeling with an alkyne-tagged fatty acid analog, supporting that the defatty-acylase activity of SIRT7 is physiologically relevant.	tagged fatty acid	127-144	sirtuin 7	Homo sapiens	13-18
27997115-10	2017	Knockdown of SIRT7 increased the lysine fatty acylation of several nuclear proteins based on metabolic labeling with an alkyne-tagged fatty acid analog, supporting that the defatty-acylase activity of SIRT7 is physiologically relevant.	tagged fatty acid	127-144	sirtuin 7	Homo sapiens	201-206
26704979-3	2016	Here we showed that the human Dicer protein interacts with SIRT7, an NAD(+)-dependent H3K18Ac (acetylated lysine 18 of histone H3) deacetylase, and holds a proportion of SIRT7 in the cytoplasm.	NAD	69-75	sirtuin 7	Homo sapiens	59-64
26704979-3	2016	Here we showed that the human Dicer protein interacts with SIRT7, an NAD(+)-dependent H3K18Ac (acetylated lysine 18 of histone H3) deacetylase, and holds a proportion of SIRT7 in the cytoplasm.	NAD	69-75	sirtuin 7	Homo sapiens	170-175
26704979-3	2016	Here we showed that the human Dicer protein interacts with SIRT7, an NAD(+)-dependent H3K18Ac (acetylated lysine 18 of histone H3) deacetylase, and holds a proportion of SIRT7 in the cytoplasm.	Lysine	106-112	sirtuin 7	Homo sapiens	59-64
26704979-3	2016	Here we showed that the human Dicer protein interacts with SIRT7, an NAD(+)-dependent H3K18Ac (acetylated lysine 18 of histone H3) deacetylase, and holds a proportion of SIRT7 in the cytoplasm.	Lysine	106-112	sirtuin 7	Homo sapiens	170-175
26907567-3	2016	Here, we reported that SIRT7 can be activated by DNA to hydrolyze the acetyl group from lysine residues in vitro on histone peptides and histones in the chromatin context.	Lysine	88-94	sirtuin 7	Homo sapiens	23-28
25970806-1	2015	SIRT7 with coenzyme NAD catalyzes protein de-acetylation.	NAD	20-23	sirtuin 7	Homo sapiens	0-5
27246221-1	2016	Sirtuin 7 (SIRT7), a histone 3 lysine 18 (H3K18) deacetylase, functions at chromatin to suppress endoplasmic reticulum (ER) stress and mitochondrial protein folding stress (PFS(mt)), and prevent the development of fatty liver disease and hematopoietic stem cell aging.	Lysine	31-37	sirtuin 7	Homo sapiens	0-9
27246221-1	2016	Sirtuin 7 (SIRT7), a histone 3 lysine 18 (H3K18) deacetylase, functions at chromatin to suppress endoplasmic reticulum (ER) stress and mitochondrial protein folding stress (PFS(mt)), and prevent the development of fatty liver disease and hematopoietic stem cell aging.	Lysine	31-37	sirtuin 7	Homo sapiens	11-16
26112889-1	2015	Sirtuins (Sirt1-Sirt7) comprise a family of nicotinamide adenine dinucleotide (NAD(+))-dependent enzymes.	NAD	44-77	sirtuin 7	Homo sapiens	16-21
26112889-1	2015	Sirtuins (Sirt1-Sirt7) comprise a family of nicotinamide adenine dinucleotide (NAD(+))-dependent enzymes.	NAD	79-85	sirtuin 7	Homo sapiens	16-21
26770454-0	2015	miR-125b suppresses the proliferation of hepatocellular carcinoma cells by targeting Sirtuin7.	mir-125b	0-8	sirtuin 7	Homo sapiens	85-93
26770454-8	2015	Western blot indicated that transfection of miR-125b mimics could significantly inhibit the expression of SIRT7 in HepG2 cells, whereas, transfection of miR-125b inhibitor could significantly increase the expression of SIRT7 in HepG2 cells.	mir-125b	44-52	sirtuin 7	Homo sapiens	106-111
26770454-8	2015	Western blot indicated that transfection of miR-125b mimics could significantly inhibit the expression of SIRT7 in HepG2 cells, whereas, transfection of miR-125b inhibitor could significantly increase the expression of SIRT7 in HepG2 cells.	mir-125b	44-52	sirtuin 7	Homo sapiens	219-224
26770454-8	2015	Western blot indicated that transfection of miR-125b mimics could significantly inhibit the expression of SIRT7 in HepG2 cells, whereas, transfection of miR-125b inhibitor could significantly increase the expression of SIRT7 in HepG2 cells.	mir-125b	153-161	sirtuin 7	Homo sapiens	219-224
26704017-9	2016	We showed TSA induced SIRT7 gene transcription and only the HDAC3, but not its catalytic domain depleted mutant, interacted with C/EBPalpha to occupy the C/EBPalpha element and repressed SIRT7 gene in the hepatocellular carcinoma cells.	trichostatin A	10-13	sirtuin 7	Homo sapiens	22-27
25644192-0	2015	Curcumin induces oxidation-dependent cell cycle arrest mediated by SIRT7 inhibition of rDNA transcription in human aortic smooth muscle cells.	Curcumin	0-8	sirtuin 7	Homo sapiens	67-72
25860861-4	2015	Here we report that Sirt7, a NAD(+)-dependent class III histone deacetylase, is over-expressed in human gastric cancer tissues.	NAD	29-35	sirtuin 7	Homo sapiens	20-25
25644192-7	2015	Curcumin caused inhibition of rDNA transcription, which could be due to SIRT7 downregulation, site-specific methylation of RNA18S5 gene promoter or both.	Curcumin	0-8	sirtuin 7	Homo sapiens	72-77
25921180-1	2015	BACKGROUND: Sirtuin7 (SIRT7) is a type of nicotinamide adenine dinucleotide oxidized form (NAD+)-dependent deacetylase and the least understood member of the sirtuins family; it is implicated in various processes, such as aging, DNA damage repair and cell signaling transduction.	NAD	42-75	sirtuin 7	Homo sapiens	12-20
25921180-1	2015	BACKGROUND: Sirtuin7 (SIRT7) is a type of nicotinamide adenine dinucleotide oxidized form (NAD+)-dependent deacetylase and the least understood member of the sirtuins family; it is implicated in various processes, such as aging, DNA damage repair and cell signaling transduction.	NAD	42-75	sirtuin 7	Homo sapiens	22-27
23680022-1	2013	Sirtuins belong to a class of NAD-dependent deacetylases, and include seven distinct isoforms, of which SIRT7 is the least studied member.	NAD	30-33	sirtuin 7	Homo sapiens	104-109
25445786-3	2015	In the present work we report the role of one of the least explored Sirtuin viz., SIRT7, under conditions of genomic stress when treated with doxorubicin.	Doxorubicin	142-153	sirtuin 7	Homo sapiens	82-87
25445786-6	2015	SIRT7 overexpressing cells when treated with low dose of doxorubicin (0.25 microM) showed delayed onset of senescence, lesser accumulation of DNA damage marker gammaH2AX and lowered levels of growth arrest markers viz., p53 and p21 when compared to doxorubicin treated control GFP expressing cells.	Doxorubicin	57-68	sirtuin 7	Homo sapiens	0-5
25445786-6	2015	SIRT7 overexpressing cells when treated with low dose of doxorubicin (0.25 microM) showed delayed onset of senescence, lesser accumulation of DNA damage marker gammaH2AX and lowered levels of growth arrest markers viz., p53 and p21 when compared to doxorubicin treated control GFP expressing cells.	Doxorubicin	249-260	sirtuin 7	Homo sapiens	0-5
25445786-8	2015	When treated with higher dose of doxorubicin (>1 microM), SIRT7 conferred resistance to apoptosis by attenuating stress activated kinases (SAPK viz., p38 and JNK) and p53 response thereby shifting the cellular fate towards senescence.	Doxorubicin	33-44	sirtuin 7	Homo sapiens	61-66
25445786-10	2015	SIRT7 mediated resistance to doxorubicin induced apoptosis and senescence was lost when p53 level was restored by nutlin treatment.	Doxorubicin	29-40	sirtuin 7	Homo sapiens	0-5
25200183-5	2014	These wide-ranging effects of SIRT7 on mitochondrial homeostasis are the consequence of the deacetylation of distinct lysine residues located in the hetero- and homodimerization domains of GABPbeta1, a master regulator of nuclear-encoded mitochondrial genes.	Lysine	118-124	sirtuin 7	Homo sapiens	30-35
24536059-1	2014	SIRT7 belongs to the Sirtuin family of NAD-dependent enzymes, the members of which play diverse roles in aging, metabolism, and disease biology.	NAD	39-42	sirtuin 7	Homo sapiens	0-5
24536059-3	2014	SIRT7 associates with chromatin, where it catalyzes selective deacetylation of lysine 18 on histone H3 (H3K18), an emerging epigenetic biomarker of aggressive tumors and poor clinical outcome in patients with cancer.	Lysine	79-85	sirtuin 7	Homo sapiens	0-5
24113281-6	2014	Indeed, SIRT7 co-fractionated with monoribosomes within a sucrose gradient.	Sucrose	58-65	sirtuin 7	Homo sapiens	8-13
24134843-1	2013	Sirt7 localizes in the nucleus (enriched in the nucleolus) and is an NAD(+)-dependent deacetylase with high selectivity for the acetylated lysine 18 of histone H3 (H3K18Ac).	Lysine	139-145	sirtuin 7	Homo sapiens	0-5
23750001-3	2013	The effect of Sirt7 was maintained in the presence of the sirtuin inhibitor nicotinamide and upon deletion or mutation of its deacetylase domain, indicating a non-catalytic function.	Niacinamide	76-88	sirtuin 7	Homo sapiens	14-19
23680022-7	2013	The two forms of SIRT7 showed reciprocal expression following serum starvation, nocodazole and okadaic acid treatments, and also during senescence.	Nocodazole	80-90	sirtuin 7	Homo sapiens	17-22
23680022-7	2013	The two forms of SIRT7 showed reciprocal expression following serum starvation, nocodazole and okadaic acid treatments, and also during senescence.	Okadaic Acid	95-107	sirtuin 7	Homo sapiens	17-22
23079745-9	2013	Bioinformatics analysis of target sites and ectopic expression in HCC cells showed that miR-125a-5p and miR-125b suppressed SIRT7 and cyclin D1 expression and induced p21(WAF1/Cip1) -dependent G1 cell cycle arrest.	125a	92-96	sirtuin 7	Homo sapiens	124-129
23079745-9	2013	Bioinformatics analysis of target sites and ectopic expression in HCC cells showed that miR-125a-5p and miR-125b suppressed SIRT7 and cyclin D1 expression and induced p21(WAF1/Cip1) -dependent G1 cell cycle arrest.	125b	108-112	sirtuin 7	Homo sapiens	124-129
22722849-3	2012	Here we show that SIRT7 is an NAD(+)-dependent H3K18Ac (acetylated lysine 18 of histone H3) deacetylase that stabilizes the transformed state of cancer cells.	NAD	30-36	sirtuin 7	Homo sapiens	18-23
22722849-3	2012	Here we show that SIRT7 is an NAD(+)-dependent H3K18Ac (acetylated lysine 18 of histone H3) deacetylase that stabilizes the transformed state of cancer cells.	Lysine	67-73	sirtuin 7	Homo sapiens	18-23
22698398-2	2012	demonstrated that SIRT7 maintains critical features that define cancer cells by removing the acetylation mark on lysine 18 of histone H3.	Lysine	113-119	sirtuin 7	Homo sapiens	18-23
34642296-9	2021	High amounts of H2O2, however, rapidly carbonylated selectively SIRT2, SIRT6, and SIRT7, which were found to accumulate carbonylation-prone amino acids.	Hydrogen Peroxide	16-20	sirtuin 7	Homo sapiens	82-87
34797559-0	2021	SIRT7 interacts with TEK (TIE2) to promote adriamycin induced metastasis in breast cancer.	Doxorubicin	43-53	sirtuin 7	Homo sapiens	0-5
34942974-0	2021	Celastrol and Melatonin Modify SIRT1, SIRT6 and SIRT7 Gene Expression and Improve the Response of Human Granulosa-Lutein Cells to Oxidative Stress.	celastrol	0-9	sirtuin 7	Homo sapiens	48-53
34942974-0	2021	Celastrol and Melatonin Modify SIRT1, SIRT6 and SIRT7 Gene Expression and Improve the Response of Human Granulosa-Lutein Cells to Oxidative Stress.	Melatonin	14-23	sirtuin 7	Homo sapiens	48-53
34942974-2	2021	SIRT1, SIRT6 and SIRT7 are involved in protection stress systems caused by OS, and they can be activated by antioxidants such as celastrol or melatonin.	celastrol	129-138	sirtuin 7	Homo sapiens	17-22
34942974-2	2021	SIRT1, SIRT6 and SIRT7 are involved in protection stress systems caused by OS, and they can be activated by antioxidants such as celastrol or melatonin.	Melatonin	142-151	sirtuin 7	Homo sapiens	17-22
34942974-3	2021	In this study, we evaluate SIRT1, SIRT6 and SIRT7 gene expression in cultured human granulosa-lutein (hGL) cells in response to OS inductors (glucose or peroxynitrite) and/or antioxidants.	Glucose	142-149	sirtuin 7	Homo sapiens	44-49
34942974-3	2021	In this study, we evaluate SIRT1, SIRT6 and SIRT7 gene expression in cultured human granulosa-lutein (hGL) cells in response to OS inductors (glucose or peroxynitrite) and/or antioxidants.	Peroxynitrous Acid	153-166	sirtuin 7	Homo sapiens	44-49
34942974-5	2021	In addition, melatonin induced SIRT1, SIRT6 and SIRT7 gene expression while celastrol only induced SIRT7 gene expression.	Melatonin	13-22	sirtuin 7	Homo sapiens	48-53
34942974-5	2021	In addition, melatonin induced SIRT1, SIRT6 and SIRT7 gene expression while celastrol only induced SIRT7 gene expression.	celastrol	76-85	sirtuin 7	Homo sapiens	99-104
34942974-8	2021	This study shows a direct effect of celastrol on SIRT7 gene expression.	celastrol	36-45	sirtuin 7	Homo sapiens	49-54
34272796-0	2021	Norcantharidin combined with paclitaxel induces endoplasmic reticulum stress mediated apoptotic effect in prostate cancer cells by targeting SIRT7 expression.	norcantharidin	0-14	sirtuin 7	Homo sapiens	141-146
34272796-0	2021	Norcantharidin combined with paclitaxel induces endoplasmic reticulum stress mediated apoptotic effect in prostate cancer cells by targeting SIRT7 expression.	Paclitaxel	29-39	sirtuin 7	Homo sapiens	141-146
34272796-9	2021	Furthermore, NCTD-PTX combination treatment was significantly decreasing the protein and mRNA expression of SIRT7 in PCa cells.	Paclitaxel	18-21	sirtuin 7	Homo sapiens	108-113
34272796-11	2021	These results indicate that NCTD combined with PTX induces ER stress-mediated apoptosis of PCa cells by regulating the SIRT7 expression axis.	Paclitaxel	47-50	sirtuin 7	Homo sapiens	119-124
19174463-6	2009	Moreover, SIRT7 is phosphorylated via the CDK1-cyclin B pathway during mitosis and dephosphorylated by a phosphatase sensitive to okadaic acid at the exit from mitosis before onset of rDNA transcription.	Okadaic Acid	130-142	sirtuin 7	Homo sapiens	10-15
34152620-0	2022	Phenol-croton oil peel enhances type-1 and type-3 collagen amounts by stimulating SIRT-6 and SIRT-7.	Phenol	0-6	sirtuin 7	Homo sapiens	93-99
34152620-0	2022	Phenol-croton oil peel enhances type-1 and type-3 collagen amounts by stimulating SIRT-6 and SIRT-7.	Croton Oil	7-17	sirtuin 7	Homo sapiens	93-99
34981113-6	2022	It found that the miR-335-5p inhibitor attenuated the downregulation of SIRT7 expression induced by oxidative stress in HUVECs, and SIRT7 overexpression exerts a rescue effect against miR-335-5p induced endothelial dysfunction.	mir-335-5p	18-28	sirtuin 7	Homo sapiens	72-77
34604215-2	2021	SIRT7 is a NAD+-dependent protein deacetylase.	NAD	11-14	sirtuin 7	Homo sapiens	0-5
34604215-7	2021	Knockdown of SIRT7 led to increased pan-lysine crotonylation (Kcr) levels in senescent fibroblasts.	pan-lysine	36-46	sirtuin 7	Homo sapiens	13-18
34604215-7	2021	Knockdown of SIRT7 led to increased pan-lysine crotonylation (Kcr) levels in senescent fibroblasts.	lysylcysteylarginine	62-65	sirtuin 7	Homo sapiens	13-18
34089287-8	2021	Through screening and molecular docking, PRKDC, CUL7, CUL1, HSPA8, HSPA4 and SIRT7 were the most likely multi-target mechanism of Cyclosporin A in the treatment of vitiligo.	Cyclosporine	130-143	sirtuin 7	Homo sapiens	77-82
34089287-10	2021	In addition, Cyclosporin A might promote the repigmentation of vitiligo by adjusting the expression of SIRT7.	Cyclosporine	13-26	sirtuin 7	Homo sapiens	103-108
34128977-5	2021	SIRT7, as a NAD+-dependent histone desuccinylase, could bind to cccDNA through interaction with HBV core protein where it catalysed histone H3K122 desuccinylation.	NAD	12-15	sirtuin 7	Homo sapiens	0-5
34128977-5	2021	SIRT7, as a NAD+-dependent histone desuccinylase, could bind to cccDNA through interaction with HBV core protein where it catalysed histone H3K122 desuccinylation.	cccdna	64-70	sirtuin 7	Homo sapiens	0-5
35513019-5	2022	Notably, SIRT7 has been shown to exert beneficial effects in cardiorenal physiology and pathophysiology via modulation of senescence, DNA damage repair, ribosomal RNA synthesis, protein biosynthesis, angiogenesis, apoptosis, superoxide generation, cardiorenal metabolism, and dysfunction.	Superoxides	225-235	sirtuin 7	Homo sapiens	9-14
35436671-1	2022	Sirtuin belongs to a family of coenzyme nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylases, which could be classified as seven isoforms (SIRT1-SIRT7).	coenzyme nicotinamide adenine dinucleotide	31-73	sirtuin 7	Homo sapiens	164-169
35369299-4	2022	Sirtuin 3 (SIRT3) is one of the seven mammalian sirtuins (SIRT1 to SIRT7), with NAD+ dependent deacetylase activity.	NAD	80-83	sirtuin 7	Homo sapiens	67-72
35616339-6	2022	Sirtuins (SIRT1-SIRT7) are a highly conserved family of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases, protecting cells from metabolic stress by deacetylating vital proteins associated with lipid metabolism.	NAD	56-89	sirtuin 7	Homo sapiens	16-21
35616339-6	2022	Sirtuins (SIRT1-SIRT7) are a highly conserved family of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases, protecting cells from metabolic stress by deacetylating vital proteins associated with lipid metabolism.	NAD	91-95	sirtuin 7	Homo sapiens	16-21
35319066-0	2022	Naphthoquinone-induced arylation inhibits Sirtuin 7 activity.	Naphthoquinones	0-14	sirtuin 7	Homo sapiens	42-51
35319066-4	2022	First, we have demonstrated that menadione and plumbagin inhibit the nucleolar NAD+-dependent deacetylase Sirtuin 7 in vitro.	Vitamin K 3	33-42	sirtuin 7	Homo sapiens	79-115
35319066-4	2022	First, we have demonstrated that menadione and plumbagin inhibit the nucleolar NAD+-dependent deacetylase Sirtuin 7 in vitro.	plumbagin	47-56	sirtuin 7	Homo sapiens	79-115
35319066-5	2022	As assessed by their inhibitions of rDNA transcription, pre-rRNA processing and formation of etoposide-induced 53BP1 foci, menadione and plumbagin inhibit also Sirtuin 7 catalytic activity in vivo.	Etoposide	93-102	sirtuin 7	Homo sapiens	160-169
35319066-5	2022	As assessed by their inhibitions of rDNA transcription, pre-rRNA processing and formation of etoposide-induced 53BP1 foci, menadione and plumbagin inhibit also Sirtuin 7 catalytic activity in vivo.	Vitamin K 3	123-132	sirtuin 7	Homo sapiens	160-169
35319066-5	2022	As assessed by their inhibitions of rDNA transcription, pre-rRNA processing and formation of etoposide-induced 53BP1 foci, menadione and plumbagin inhibit also Sirtuin 7 catalytic activity in vivo.	plumbagin	137-146	sirtuin 7	Homo sapiens	160-169
35319066-6	2022	Second, we have established that in experimental conditions in which the sulfhydryl arylation by menadione or plumbagin is prevented by the thiol reducing agent N-acetyl-L-cysteine, the inhibition of Sirtuin 7 catalytic activity is also prevented.	Vitamin K 3	97-106	sirtuin 7	Homo sapiens	200-209
35319066-6	2022	Second, we have established that in experimental conditions in which the sulfhydryl arylation by menadione or plumbagin is prevented by the thiol reducing agent N-acetyl-L-cysteine, the inhibition of Sirtuin 7 catalytic activity is also prevented.	plumbagin	110-119	sirtuin 7	Homo sapiens	200-209
35319066-6	2022	Second, we have established that in experimental conditions in which the sulfhydryl arylation by menadione or plumbagin is prevented by the thiol reducing agent N-acetyl-L-cysteine, the inhibition of Sirtuin 7 catalytic activity is also prevented.	Sulfhydryl Compounds	140-145	sirtuin 7	Homo sapiens	200-209
35319066-6	2022	Second, we have established that in experimental conditions in which the sulfhydryl arylation by menadione or plumbagin is prevented by the thiol reducing agent N-acetyl-L-cysteine, the inhibition of Sirtuin 7 catalytic activity is also prevented.	Acetylcysteine	161-180	sirtuin 7	Homo sapiens	200-209
35319066-7	2022	Finally, we discuss here how inhibition of Sirtuin 7 might be critical in determining menadione or plumbagin as anti-tumor agents that can be used in combination in anti-tumoral strategies.	plumbagin	99-108	sirtuin 7	Homo sapiens	43-52
35411569-0	2022	Combination of resolvin E1 and lipoxin A4 promotes the resolution of pulpitis by inhibiting NF-kappaB activation through upregulating sirtuin 7 in dental pulp fibroblasts.	5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid	15-26	sirtuin 7	Homo sapiens	134-143
35411569-0	2022	Combination of resolvin E1 and lipoxin A4 promotes the resolution of pulpitis by inhibiting NF-kappaB activation through upregulating sirtuin 7 in dental pulp fibroblasts.	lipoxin A4	31-41	sirtuin 7	Homo sapiens	134-143
35422493-0	2022	O-GlcNAcylation and stablization of SIRT7 promote pancreatic cancer progression by blocking the SIRT7-REGgamma interaction.	o-glcnacylation	0-15	sirtuin 7	Homo sapiens	96-101
35422493-7	2022	In addition, SIRT7 O-GlcNAcylation at the serine 136 residue (S136) is required to maintain its protein stability and deacetylation ability.	Serine	42-48	sirtuin 7	Homo sapiens	13-18
35174171-6	2021	Our docking results also revealed that ARG-120, TRP-126, and HIS-187 were critical sites responsible for interaction of SIRT7 with small molecules.	Arginine	39-42	sirtuin 7	Homo sapiens	120-125
35174171-6	2021	Our docking results also revealed that ARG-120, TRP-126, and HIS-187 were critical sites responsible for interaction of SIRT7 with small molecules.	Tryptophan	48-51	sirtuin 7	Homo sapiens	120-125
35174171-6	2021	Our docking results also revealed that ARG-120, TRP-126, and HIS-187 were critical sites responsible for interaction of SIRT7 with small molecules.	Histidine	61-64	sirtuin 7	Homo sapiens	120-125
35046516-7	2022	The SIRT7-mediated dessuccinylation of PRMT5 lysine 387 fails to bind to STUB1, decreasing PRMT5 ubiquitination and increasing the interaction between PRMT5 and Mep50, which promotes the formation of the PRMT5-Mep50 octamer.	Lysine	45-51	sirtuin 7	Homo sapiens	4-9