PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
34282704-6	2021	OxoDNA induces mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4), thereby sensitizing the brain to oxidative stress-induced JNK activation and BACE1 transcription.	oxodna	0-6	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	15-70
34930918-7	2021	Further, the sensitivity of cervical cancer cells to cisplatin chemotherapy could be reduced by the SOX6-induced autophagy in vitro and in vivo, while such a phenomenon could be turned over by autophagy-specific inhibitor and MAP4K4 inhibitor, respectively.	Cisplatin	53-62	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	226-232
34930918-8	2021	Moreover, cisplatin itself could promote the expression of endogenous SOX6 and subsequently the MAP4K4-mediated autophagy in cervical cancer cells, which might in turn reduce the sensitivity of these cells to cisplatin treatment.	Cisplatin	10-19	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	96-102
34930918-8	2021	Moreover, cisplatin itself could promote the expression of endogenous SOX6 and subsequently the MAP4K4-mediated autophagy in cervical cancer cells, which might in turn reduce the sensitivity of these cells to cisplatin treatment.	Cisplatin	209-218	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	96-102
34930918-9	2021	These findings uncovered the underlying mechanism and potential significance of SOX6-induced autophagy, and shed new light on the usage of MAP4K4 inhibitor or autophagy-specific inhibitor for sensitizing cervical cancer cells to the platinum-based chemotherapy.	Platinum	233-241	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	139-145
34419892-0	2021	Discovery of 4-aminoquinolines as highly selective TGFbetaR1 inhibitors with an attenuated MAP4K4 profile for potential applications in immuno-oncology.	4-aminoquinoline	13-30	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	91-97
34282704-6	2021	OxoDNA induces mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4), thereby sensitizing the brain to oxidative stress-induced JNK activation and BACE1 transcription.	oxodna	0-6	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	72-78
33551189-10	2021	After adding 3mM N-Acetylcysteine to HGK cultures, increased fluorescence intensity and protein amounts of Involucrin and Filaggrin indicated enhanced differentiation (p<0.05).	Acetylcysteine	17-33	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	37-40
34225773-14	2021	Importantly, tiRNA-Gly can induce exon 16 splicing of MAP4K4 mRNA leading to phosphorylation of downstream signaling pathway, which is RBM17 dependent.	Glycine	19-22	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	54-60
33737052-2	2021	We found that GNE 495 and PF 06260933 (both potent and selective MAP4K4 inhibitors) regulated human platelet activation.	gne	14-17	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	65-71
33737052-2	2021	We found that GNE 495 and PF 06260933 (both potent and selective MAP4K4 inhibitors) regulated human platelet activation.	PF-6260933	26-37	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	65-71
34032269-9	2021	The Ser/Thr protein phosphatase inhibitor calyculin A (CalA) induced MAP4K4 hyperphosphorylation, with phosphorylation of the activation loop and extensive phosphorylation of the linker between the kinase and CNH domains.	calyculin A	42-53	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	69-75
34032269-9	2021	The Ser/Thr protein phosphatase inhibitor calyculin A (CalA) induced MAP4K4 hyperphosphorylation, with phosphorylation of the activation loop and extensive phosphorylation of the linker between the kinase and CNH domains.	calyculin A	55-59	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	69-75
34032269-11	2021	MAP4K4 associated with myosin in untreated cardiomyocytes, and this was lost with CalA-treatment.	calyculin A	82-86	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	0-6
34032269-14	2021	Surprisingly, FLAG-MAP4K4 inhibited JNK activation by H2O2 in cardiomyocytes and increased myofibrillar organisation.	Hydrogen Peroxide	54-58	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	19-25
32694738-0	2020	Selective protection of human cardiomyocytes from anthracycline cardiotoxicity by small molecule inhibitors of MAP4K4.	Anthracyclines	50-63	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	111-117
33311569-0	2021	LncRNA LINC01857 promotes cell growth and diminishes apoptosis via PI3K/mTOR pathway and EMT process by regulating miR-141-3p/MAP4K4 axis in diffuse large B-cell lymphoma.	linc01857	7-16	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	126-132
33311569-5	2021	Bioinformatics analysis and luciferase reporter assay confirmed that LINC01857 may serve as a sponge for miR-141-3p and miR-141-3p may target MAP4K4.	linc01857	69-78	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	142-148
33311569-6	2021	Mechanically, the regulatory action of miR-141-3p/MAP4K4 on DLBCL cellular behaviors was regulated by LINC01857.	linc01857	102-111	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	50-56
31912905-5	2020	Neratinib altered pancreatic tumor cell morphology which was associated with MST4 degradation reduced Ezrin phosphorylation and enhanced phosphorylation of MAP4K4 and LATS1/2.	neratinib	0-9	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	156-162
32694738-3	2020	A further role for MAP4K4 was proposed in heart muscle cell death triggered by cardiotoxic anti-cancer drugs, given its reported activation in failing human hearts with doxorubicin (DOX) cardiomyopathy, and its activation acutely by DOX in cultured cardiomyocytes.	Doxorubicin	169-180	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	19-25
32694738-3	2020	A further role for MAP4K4 was proposed in heart muscle cell death triggered by cardiotoxic anti-cancer drugs, given its reported activation in failing human hearts with doxorubicin (DOX) cardiomyopathy, and its activation acutely by DOX in cultured cardiomyocytes.	Doxorubicin	182-185	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	19-25
32694738-3	2020	A further role for MAP4K4 was proposed in heart muscle cell death triggered by cardiotoxic anti-cancer drugs, given its reported activation in failing human hearts with doxorubicin (DOX) cardiomyopathy, and its activation acutely by DOX in cultured cardiomyocytes.	Doxorubicin	233-236	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	19-25
32694738-4	2020	Here, we report successful protection from DOX in two independent hPSC-CM lines, using two potent, highly selective MAP4K4 inhibitors.	Doxorubicin	43-46	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	116-122
32694738-5	2020	The MAP4K4 inhibitors enhanced viability and reduced apoptosis at otherwise lethal concentrations of DOX, and preserved cardiomyocyte function, as measured by spontaneous calcium transients, at sub-maximal ones.	Doxorubicin	101-104	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	4-10
32694738-5	2020	The MAP4K4 inhibitors enhanced viability and reduced apoptosis at otherwise lethal concentrations of DOX, and preserved cardiomyocyte function, as measured by spontaneous calcium transients, at sub-maximal ones.	Calcium	171-178	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	4-10
32694738-7	2020	Thus, MAP4K4 is a plausible, tractable, selective therapeutic target in DOX-induced human heart muscle cell death.	Doxorubicin	72-75	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	6-12
30475644-0	2019	Role of TLR4-MAP4K4 signaling pathway in models of oxygen-induced retinopathy.	Oxygen	51-57	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	13-19
29620289-7	2018	Promotion of MAP4K4 protein expression reduced the effects of miRNA-141 on the toxicity of CD4+ T cells on breast cancer cells.	mirna-141	62-71	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	13-19
30429233-7	2018	At the present study, we found overexpression of miR-141 could inhibit proliferation, migration, tumor-forming and invasive potential of CRC cells in vitro and mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) was verified as a directed target of miR-141 The combination treatment of miR-141 with 5-FU, directly targetting MAP4K4, could better inhibit invasion and metastasis of CRC cells colony than either one alone.	Fluorouracil	312-316	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	160-215
30429233-7	2018	At the present study, we found overexpression of miR-141 could inhibit proliferation, migration, tumor-forming and invasive potential of CRC cells in vitro and mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) was verified as a directed target of miR-141 The combination treatment of miR-141 with 5-FU, directly targetting MAP4K4, could better inhibit invasion and metastasis of CRC cells colony than either one alone.	Fluorouracil	312-316	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	217-223
30429233-8	2018	Furthermore, overexpression of miR-141, targetting MAP4K4, enhanced the effected of 5-FU and suppressed the malignant biological behaviors, in vivo Our findings showed that 5-FU inhibited malignant behavior of human CRC cells in vitro and in vivo by enhancing the efficiency of miR-141 Our data suggested that targetting the miR-141/MAP4K4 signaling pathway could be a potential molecular target that may enhance chemotherapeutic efficacy in the treatment of CRC.	Fluorouracil	84-88	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	51-57
30429233-8	2018	Furthermore, overexpression of miR-141, targetting MAP4K4, enhanced the effected of 5-FU and suppressed the malignant biological behaviors, in vivo Our findings showed that 5-FU inhibited malignant behavior of human CRC cells in vitro and in vivo by enhancing the efficiency of miR-141 Our data suggested that targetting the miR-141/MAP4K4 signaling pathway could be a potential molecular target that may enhance chemotherapeutic efficacy in the treatment of CRC.	Fluorouracil	173-177	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	51-57
30429233-8	2018	Furthermore, overexpression of miR-141, targetting MAP4K4, enhanced the effected of 5-FU and suppressed the malignant biological behaviors, in vivo Our findings showed that 5-FU inhibited malignant behavior of human CRC cells in vitro and in vivo by enhancing the efficiency of miR-141 Our data suggested that targetting the miR-141/MAP4K4 signaling pathway could be a potential molecular target that may enhance chemotherapeutic efficacy in the treatment of CRC.	Fluorouracil	173-177	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	333-339
30475644-9	2019	Role of TLR4-MAP4K4 signaling pathway in models of oxygen-induced retinopathy.	Oxygen	51-57	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	13-19
30258193-0	2018	HGK-sestrin 2 signaling-mediated autophagy contributes to antitumor efficacy of Tanshinone IIA in human osteosarcoma cells.	tanshinone	80-90	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	0-3
29570292-3	2018	One such approach arose from the observation that carboxylic acid-based intermediates employed in our discovery efforts retained high MAP4K4 inhibitory potency and were devoid of the TDI risk.	Carboxylic Acids	50-65	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	134-140
28838994-0	2017	The Bruton tyrosine kinase inhibitor CC-292 shows activity in mantle cell lymphoma and synergizes with lenalidomide and NIK inhibitors depending on nuclear factor-kappaB mutational status.	spebrutinib	37-43	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	120-123
28306189-7	2017	Our results further showed that downregulation of MAP4K4 prevented ERK reactivation in EGFR inhibitor erlotinib-treated lung adenocarcinoma cells.	Erlotinib Hydrochloride	102-111	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	50-56
28771231-8	2017	Streptozotocin-induced diabetic CD-1 mice exhibited suppression of both FGFR1 and P-MAP4K4 expression levels associated with the induction of TGFbeta/smad3 signaling and EndMT in their hearts and kidneys; those were restored by AcSDKP treatment.	Streptozocin	0-14	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	84-90
26918832-7	2016	Moreover, methylation frequencies of the HGK promoter were increased in T2D patients and correlated with glucose levels after glucose-tolerance tests.	Glucose	105-112	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	41-44
27754501-0	2016	Regulation of MAP4K4 gene expression by RNA interference through an engineered theophylline-dependent hepatitis delta virus ribozyme switch.	Theophylline	79-91	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	14-20
26918832-7	2016	Moreover, methylation frequencies of the HGK promoter were increased in T2D patients and correlated with glucose levels after glucose-tolerance tests.	Glucose	126-133	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	41-44
26856188-0	2016	Tc-99m Glu-Cys-Gly-His-Gly-Lys (ECG-HGK), a novel Tc-99m labeled hexapeptide for molecular tumor imaging.	Technetium	0-2	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	36-39
26856188-0	2016	Tc-99m Glu-Cys-Gly-His-Gly-Lys (ECG-HGK), a novel Tc-99m labeled hexapeptide for molecular tumor imaging.	Glutamic Acid	7-10	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	36-39
26856188-5	2016	The uptake of Tc-99m ECG-HGK within HT-1080 cells was evaluated in vitro.	tc-99	14-19	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	25-28
26856188-0	2016	Tc-99m Glu-Cys-Gly-His-Gly-Lys (ECG-HGK), a novel Tc-99m labeled hexapeptide for molecular tumor imaging.	Cysteine	11-14	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	36-39
26856188-0	2016	Tc-99m Glu-Cys-Gly-His-Gly-Lys (ECG-HGK), a novel Tc-99m labeled hexapeptide for molecular tumor imaging.	Glycine	15-18	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	36-39
26856188-8	2016	The uptake of Tc-99m ECG-HGK within the HT-1080 tumor cells had been demonstrated by in vitro studies.	tc-99	14-19	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	25-28
26856188-0	2016	Tc-99m Glu-Cys-Gly-His-Gly-Lys (ECG-HGK), a novel Tc-99m labeled hexapeptide for molecular tumor imaging.	Histidine	19-22	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	36-39
26856188-0	2016	Tc-99m Glu-Cys-Gly-His-Gly-Lys (ECG-HGK), a novel Tc-99m labeled hexapeptide for molecular tumor imaging.	Glycine	23-26	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	36-39
26856188-9	2016	The gamma camera imaging in the murine model showed that Tc-99m ECG-HGK was accumulated substantially in the HT-1080 tumor (tumor-to-muscle ratio = 5.7 +- 1.4 at 4 h), and the tumoral uptake was blocked by the co-injection of excess HGK (tumor-to-muscle ratio = 2.8 +- 0.6 at 4 h).	Technetium	57-59	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	68-71
26856188-0	2016	Tc-99m Glu-Cys-Gly-His-Gly-Lys (ECG-HGK), a novel Tc-99m labeled hexapeptide for molecular tumor imaging.	Lysine	27-30	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	36-39
26856188-10	2016	In the present study, Tc-99m ECG-HGK was developed as a new tumor imaging agents.	tc-99	22-27	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	33-36
26856188-0	2016	Tc-99m Glu-Cys-Gly-His-Gly-Lys (ECG-HGK), a novel Tc-99m labeled hexapeptide for molecular tumor imaging.	tc-99	0-5	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	36-39
26856188-11	2016	Our in vitro and in vivo studies revealed specific function of Tc-99m ECG-HGK for tumor imaging.	Technetium	63-65	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	74-77
25337707-0	2014	A novel aminothiazole KY-05009 with potential to inhibit Traf2- and Nck-interacting kinase (TNIK) attenuates TGF-beta1-mediated epithelial-to-mesenchymal transition in human lung adenocarcinoma A549 cells.	2-aminothiazole	8-21	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	68-90
26551034-0	2015	Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N   S (nN   sigma*S-X) Interaction for Conformational Constraint.	diarylmethanesulfonamide	47-71	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	130-132
26551034-2	2015	Diarylmethanesulfonamide hit 6 (hGK-hGKRP IC50 = 1.2 muM) was optimized to lead compound 32 (AMG-0696; hGK-hGKRP IC50 = 0.0038 muM).	diarylmethanesulfonamide	0-24	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	32-35
26551034-2	2015	Diarylmethanesulfonamide hit 6 (hGK-hGKRP IC50 = 1.2 muM) was optimized to lead compound 32 (AMG-0696; hGK-hGKRP IC50 = 0.0038 muM).	diarylmethanesulfonamide	0-24	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	36-39
25908259-0	2015	Neuritogenic militarinone-inspired 4-hydroxypyridones target the stress pathway kinase MAP4K4.	militarinone	13-25	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	87-93
25908259-0	2015	Neuritogenic militarinone-inspired 4-hydroxypyridones target the stress pathway kinase MAP4K4.	4-hydroxypyridones	35-53	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	87-93
25908259-3	2015	Reported herein is the synthesis of a militarinone-inspired 4-hydroxy-2-pyridone collection, its investigation for enhancement of neurite outgrowth, and the discovery of the stress pathway kinase MAP4K4 as a target of the discovered neuritogenic pyridones.	militarinone	38-50	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	196-202
25908259-4	2015	The most potent 4-hydroxy-2-pyridone is a selective ATP-competitive inhibitor of MAP4K4 but not of the other stress pathway related kinases, as proven by biochemical analysis and by a crystal structure of the inhibitor in complex with MAP4K4.	2,4-dihydroxypyridine	16-36	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	81-87
25908259-4	2015	The most potent 4-hydroxy-2-pyridone is a selective ATP-competitive inhibitor of MAP4K4 but not of the other stress pathway related kinases, as proven by biochemical analysis and by a crystal structure of the inhibitor in complex with MAP4K4.	2,4-dihydroxypyridine	16-36	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	235-241
25908259-4	2015	The most potent 4-hydroxy-2-pyridone is a selective ATP-competitive inhibitor of MAP4K4 but not of the other stress pathway related kinases, as proven by biochemical analysis and by a crystal structure of the inhibitor in complex with MAP4K4.	Adenosine Triphosphate	52-55	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	81-87
25908259-4	2015	The most potent 4-hydroxy-2-pyridone is a selective ATP-competitive inhibitor of MAP4K4 but not of the other stress pathway related kinases, as proven by biochemical analysis and by a crystal structure of the inhibitor in complex with MAP4K4.	Adenosine Triphosphate	52-55	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	235-241
25337707-0	2014	A novel aminothiazole KY-05009 with potential to inhibit Traf2- and Nck-interacting kinase (TNIK) attenuates TGF-beta1-mediated epithelial-to-mesenchymal transition in human lung adenocarcinoma A549 cells.	5-(4-methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide	22-30	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	68-90
24386391-2	2013	The kinase that directly regulates the canonical NFkappaB transcriptional pathway, Inhibitor of kappaB kinase beta (IKKbeta), undergoes activation by Ser phosphorylation mediated by NIK or TAK1 in response to inflammatory signals.	Serine	150-153	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	182-185
25139565-0	2014	Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors.	pyrrolo(2,1-f)(1,2,4)triazine	68-97	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	98-104
25139565-2	2014	In an effort to generate small molecule MAP4K4 inhibitors, a fragment-based screen was carried out and a pyrrolotriazine fragment with excellent ligand efficiency was identified.	pyrrolotriazine	105-120	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	40-46
24681727-4	2014	In this study, it was demonstrated that in vitro, MAP4K4 deletion remarkably suppressed CD4(+) T cell proliferation in response to phorbol 12-myristate 13-acetate (PMA) and ionomycin, which was not due to enhancing cell apoptosis.	Tetradecanoylphorbol Acetate	131-162	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	50-56
24681727-4	2014	In this study, it was demonstrated that in vitro, MAP4K4 deletion remarkably suppressed CD4(+) T cell proliferation in response to phorbol 12-myristate 13-acetate (PMA) and ionomycin, which was not due to enhancing cell apoptosis.	Tetradecanoylphorbol Acetate	164-167	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	50-56
24681727-4	2014	In this study, it was demonstrated that in vitro, MAP4K4 deletion remarkably suppressed CD4(+) T cell proliferation in response to phorbol 12-myristate 13-acetate (PMA) and ionomycin, which was not due to enhancing cell apoptosis.	Ionomycin	173-182	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	50-56
24673130-0	2014	Discovery of selective 4-Amino-pyridopyrimidine inhibitors of MAP4K4 using fragment-based lead identification and optimization.	4-amino-pyridopyrimidine	23-47	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	62-68
24194395-9	2014	Furthermore, silencing MAP4K4, the upstream kinase of JNK, attenuated both apoptosis and cell death caused by sertraline.	Sertraline	110-120	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	23-29
24194395-10	2014	Taken together, our findings suggest that sertraline induced apoptosis in HepG2 cells at least partially via activation of the TNF-MAP4K4-JNK cascade signaling pathway.	Sertraline	42-52	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	131-137
23924694-2	2013	We previously identified mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4), a sterile 20 protein kinase reported to be upstream of c-Jun NH2-terminal kinase (JNK) signaling, as a novel negative regulator of insulin-stimulated glucose transport in adipocytes.	Glucose	241-248	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	25-80
23924694-2	2013	We previously identified mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4), a sterile 20 protein kinase reported to be upstream of c-Jun NH2-terminal kinase (JNK) signaling, as a novel negative regulator of insulin-stimulated glucose transport in adipocytes.	Glucose	241-248	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	82-88
23924694-5	2013	Thus, while Map4k4 silencing in adipocytes enhances the expression of lipogenic enzymes, concomitant with increased conversion of (14)C-glucose and (14)C-acetate into TGs and fatty acids, JNK1 and JNK2 depletion causes the opposite effects.	)c-glucose	133-143	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	12-18
23419643-1	2013	Galactosylated trimethyl chitosan-cysteine (GTC) nanoparticles (NPs) were developed for oral delivery of a mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) siRNA (siMap4k4) to the activated macrophages for treatment of dextran sulfate sodium (DSS)-induced ulcerative colitis (UC).	trimethyl chitosan-cysteine	15-42	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	107-162
23924694-5	2013	Thus, while Map4k4 silencing in adipocytes enhances the expression of lipogenic enzymes, concomitant with increased conversion of (14)C-glucose and (14)C-acetate into TGs and fatty acids, JNK1 and JNK2 depletion causes the opposite effects.	14)c-acetate	149-161	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	12-18
23924694-5	2013	Thus, while Map4k4 silencing in adipocytes enhances the expression of lipogenic enzymes, concomitant with increased conversion of (14)C-glucose and (14)C-acetate into TGs and fatty acids, JNK1 and JNK2 depletion causes the opposite effects.	trichlorosucrose	167-170	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	12-18
23924694-7	2013	Map4k4 silencing in cultured adipocytes elevates both the total protein expression and cleavage of sterol-regulated element binding protein-1 (Srebp-1) in a rapamycin-sensitive manner, consistent with Map4k4 signaling via mechanistic target of rapamycin complex 1 (mTORC1).	Sirolimus	157-166	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	0-6
23419643-0	2013	Galactosylated trimethyl chitosan-cysteine nanoparticles loaded with Map4k4 siRNA for targeting activated macrophages.	trimethyl chitosan	15-33	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	69-75
23419643-1	2013	Galactosylated trimethyl chitosan-cysteine (GTC) nanoparticles (NPs) were developed for oral delivery of a mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) siRNA (siMap4k4) to the activated macrophages for treatment of dextran sulfate sodium (DSS)-induced ulcerative colitis (UC).	trimethyl chitosan-cysteine	15-42	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	164-170
23419643-0	2013	Galactosylated trimethyl chitosan-cysteine nanoparticles loaded with Map4k4 siRNA for targeting activated macrophages.	Cysteine	34-42	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	69-75
23419643-1	2013	Galactosylated trimethyl chitosan-cysteine (GTC) nanoparticles (NPs) were developed for oral delivery of a mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) siRNA (siMap4k4) to the activated macrophages for treatment of dextran sulfate sodium (DSS)-induced ulcerative colitis (UC).	guanidine thiocyanate	44-47	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	107-162
23419643-1	2013	Galactosylated trimethyl chitosan-cysteine (GTC) nanoparticles (NPs) were developed for oral delivery of a mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) siRNA (siMap4k4) to the activated macrophages for treatment of dextran sulfate sodium (DSS)-induced ulcerative colitis (UC).	guanidine thiocyanate	44-47	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	164-170
20038583-5	2010	However, depletion of Map4k4 significantly enhances [(35)S]methionine/cysteine incorporation into proteins, suggesting that Map4k4 signaling decreases protein translation.	Methionine	59-69	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	22-28
23232060-1	2013	A series of compounds based on a 4-phenyl-2-phenylaminopyridine scaffold that are potent and selective inhibitors of Traf2- and Nck-interacting kinase (TNIK) activity are described.	4-phenyl-2-phenylaminopyridine	33-63	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	128-150
23094072-2	2012	We investigated whether common single nucleotide polymorphisms (SNPs) in the MAP4K4 locus associate with glucose intolerance, insulin resistance, impaired insulin release, or elevated plasma cytokines.	Glucose	105-112	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	77-83
20096267-2	2010	However, in the course of this work, we unexpectedly found that the pyrazolo[4,3-c]isoquinolines initially reported as NIK inhibitors were neither inhibitors of this enzyme nor of the alternative NF-kappaB pathway, but were in fact inhibitors of another kinase, the TGF-beta activated kinase 1 (TAK1) which is involved in the classical NF-kappaB pathway.	pyrazolo[4,3-c]isoquinolines	68-96	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	119-122
20038583-5	2010	However, depletion of Map4k4 significantly enhances [(35)S]methionine/cysteine incorporation into proteins, suggesting that Map4k4 signaling decreases protein translation.	Methionine	59-69	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	124-130
20038583-5	2010	However, depletion of Map4k4 significantly enhances [(35)S]methionine/cysteine incorporation into proteins, suggesting that Map4k4 signaling decreases protein translation.	Cysteine	70-78	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	22-28
20038583-5	2010	However, depletion of Map4k4 significantly enhances [(35)S]methionine/cysteine incorporation into proteins, suggesting that Map4k4 signaling decreases protein translation.	Cysteine	70-78	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	124-130
17227768-2	2007	We tested whether mitogenic-activated protein kinase kinase kinase kinase isoform 4 (MAP4K4) causes the TNF-alpha-induced negative regulation of extracellular signal-regulated kinase-1/2 (ERK-1/2), c-Jun NH2-terminal kinase (JNK), and the insulin receptor substrate-1 (IRS-1) on the insulin signaling pathway governing glucose metabolism.	Glucose	319-326	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	85-91
19690174-0	2009	Silencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretion.	Glucose	153-160	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	10-46
19690174-0	2009	Silencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretion.	Glucose	153-160	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	48-54
19596065-7	2009	To strengthen the findings, we perturbed the PTK/PTP balance using a PTP inhibitor, Na(3)VO(4), which caused NF-kappaB activation through phosphorylated NIK/IKK and MAPKs.	na(3)vo(4)	84-94	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	153-156
19492062-0	2009	Conserved threonine residues within the A-loop of the receptor NIK differentially regulate the kinase function required for antiviral signaling.	Threonine	10-19	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	63-66
19492062-8	2009	Furthermore, mutations at Thr-474 and Thr-469 residues antagonistically affected NIK-mediated nuclear relocation of the downstream effector rpL10.	Threonine	26-29	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	81-84
19492062-8	2009	Furthermore, mutations at Thr-474 and Thr-469 residues antagonistically affected NIK-mediated nuclear relocation of the downstream effector rpL10.	Threonine	38-41	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	81-84
17561510-8	2007	The affinity of pentaubiquitin binding to hGK is regulated by the ligand (d-glucose)-dependent conformational state of the site.	Glucose	74-83	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	42-45
17227768-3	2007	Using small interfering RNA (siRNA) to suppress the expression of MAP4K4 protein 85% in primary human skeletal muscle cells, we provide evidence that TNF-alpha-induced insulin resistance on glucose uptake was completely prevented.	Glucose	190-197	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	66-72
17227768-4	2007	MAP4K4 silencing inhibited TNF-alpha-induced negative signaling inputs by preventing excessive JNK and ERK-1/2 phosphorylation, as well as IRS-1 serine phosphorylation.	Serine	145-151	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	0-6
17227768-6	2007	Depletion of MAP4K4 also prevented TNF-alpha-induced insulin resistance on Akt and the Akt substrate 160 (AS160), providing evidence that appropriate insulin signaling inputs for glucose metabolism were rescued.	Glucose	179-186	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	13-19
17227768-8	2007	Thus, strategies to inhibit MAP4K4 may be efficacious in the prevention of TNF-alpha-induced inhibitory signals that cause skeletal muscle insulin resistance on glucose metabolism in humans.	Glucose	161-168	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	28-34
17227768-9	2007	Moreover, in myotubes from insulin-resistant type II diabetic patients, siRNA against MAP4K4, MAP2K4, or MAP2K1 restored insulin action on glucose uptake to levels observed in healthy subjects.	Glucose	139-146	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	86-92
17227768-10	2007	Collectively, our results demonstrate that MAP4K4 silencing prevents insulin resistance in human skeletal muscle and restores appropriate signaling inputs to enhance glucose uptake.	Glucose	166-173	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	43-49
16461467-2	2006	Here we report an RNA interference-based screen of protein kinases expressed in adipocytes and identify four negative regulators of insulin-responsive glucose transport: the protein kinases PCTAIRE-1 (PCTK1), PFTAIRE-1 (PFTK1), IkappaB kinase alpha, and MAP4K4/NIK.	Glucose	151-158	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	254-260
16938849-4	2006	In vitro assays show that NIK interacts directly with ERM proteins, binding their N termini and phosphorylating a conserved C-terminal threonine.	Threonine	135-144	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	26-29
16461467-2	2006	Here we report an RNA interference-based screen of protein kinases expressed in adipocytes and identify four negative regulators of insulin-responsive glucose transport: the protein kinases PCTAIRE-1 (PCTK1), PFTAIRE-1 (PFTK1), IkappaB kinase alpha, and MAP4K4/NIK.	Glucose	151-158	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	261-264
16461467-0	2006	An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARgamma, adipogenesis, and insulin-responsive hexose transport.	Hexoses	130-136	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	44-50
16461467-0	2006	An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARgamma, adipogenesis, and insulin-responsive hexose transport.	Hexoses	130-136	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	51-54
16461467-4	2006	We characterized one of these hits, MAP4K4/NIK, and found that it is unique among mitogen-activated protein (MAP) kinases expressed in cultured adipocytes in attenuating hexose transport.	Hexoses	170-176	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	36-42
16461467-4	2006	We characterized one of these hits, MAP4K4/NIK, and found that it is unique among mitogen-activated protein (MAP) kinases expressed in cultured adipocytes in attenuating hexose transport.	Hexoses	170-176	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	43-46
16461467-6	2006	RNA interference-mediated depletion of MAP4K4/NIK early in differentiation enhances adipogenesis and triglyceride deposition, and even in fully differentiated adipocytes its loss up-regulates GLUT4.	Triglycerides	101-113	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	39-45
16461467-6	2006	RNA interference-mediated depletion of MAP4K4/NIK early in differentiation enhances adipogenesis and triglyceride deposition, and even in fully differentiated adipocytes its loss up-regulates GLUT4.	Triglycerides	101-113	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	46-49
16461467-9	2006	These results reveal a MAP4K4/NIK-dependent signaling pathway that potently inhibits PPARgamma-responsive gene expression, adipogenesis, and insulin-stimulated glucose transport.	Glucose	160-167	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	23-29
16461467-9	2006	These results reveal a MAP4K4/NIK-dependent signaling pathway that potently inhibits PPARgamma-responsive gene expression, adipogenesis, and insulin-stimulated glucose transport.	Glucose	160-167	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	30-33
14506238-7	2003	In this study, we found that the amino acid sequence His-Gly-Lys (HGK) in D5H is the core motif for inhibition of adhesion and invasion of MDA-MB-231 cells in vitro.	Histidine	53-56	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	66-69
14506238-7	2003	In this study, we found that the amino acid sequence His-Gly-Lys (HGK) in D5H is the core motif for inhibition of adhesion and invasion of MDA-MB-231 cells in vitro.	Glycine	57-60	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	66-69
14506238-7	2003	In this study, we found that the amino acid sequence His-Gly-Lys (HGK) in D5H is the core motif for inhibition of adhesion and invasion of MDA-MB-231 cells in vitro.	Lysine	61-64	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	66-69
14506238-7	2003	In this study, we found that the amino acid sequence His-Gly-Lys (HGK) in D5H is the core motif for inhibition of adhesion and invasion of MDA-MB-231 cells in vitro.	vidofludimus	74-77	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	66-69
12387898-0	2002	A novel GTP-binding protein hGBP3 interacts with NIK/HGK.	Guanosine Triphosphate	8-11	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	49-52
12387898-0	2002	A novel GTP-binding protein hGBP3 interacts with NIK/HGK.	Guanosine Triphosphate	8-11	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	53-56
10669731-6	2000	EphB1 kinase activity and phosphorylation of a juxtamembrane tyrosine (Y594), conserved in all Eph receptors, are both critical for NIK activation by EphB1.	Tyrosine	61-69	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	132-135
10669731-6	2000	EphB1 kinase activity and phosphorylation of a juxtamembrane tyrosine (Y594), conserved in all Eph receptors, are both critical for NIK activation by EphB1.	y594	71-75	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	132-135
10669731-8	2000	Tyrosine-phosphorylated p62(dok) most probably binds directly to the SH2 domain of Nck and RasGAP and indirectly to NIK bound to the SH3 domain of Nck.	Tyrosine	0-8	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	116-119
10669731-10	2000	Taken together, these findings support a model in which the recruitment of the Ste20 kinase NIK to phosphotyrosine-containing proteins by Nck is an important proximal step in the signaling cascade downstream of EphRs.	Phosphotyrosine	99-114	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	92-95
8587034-0	1995	[Synthesis of estimated metabolites of 9-amino-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinoline monohydrochloride monohydrate (NIK-247).	9-amino-2,3,5,6,7,8-hexahydro-1h-cyclopenta[b]quinoline monohydrochloride monohydrate	39-124	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	126-129
8587034-2	1995	The two mono-hydroxylated metabolites of 9-amino-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinoline monohydrochloride monohydrate (NIK-247), which is a new drug for the treatment of dementia, were synthesized to determine their chemical structures.	9-amino-2,3,5,6,7,8-hexahydro-1h-cyclopenta[b]quinoline monohydrochloride monohydrate	41-126	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	128-131
8587035-0	1995	[Synthesis of estimated metabolites of 9-amino-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinoline monohydrochloride monohydrate (NIK-247).	9-amino-2,3,5,6,7,8-hexahydro-1h-cyclopenta[b]quinoline monohydrochloride monohydrate	39-124	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	126-129
8587035-3	1995	The two dihydroxylated metabolites of 9-amino-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinoline monohydrochloride monohydrate (NIK-247), which is a new drug for the treatment of dementia, were synthesized to determine their chemical structures.	9-amino-2,3,5,6,7,8-hexahydro-1h-cyclopenta[b]quinoline monohydrochloride monohydrate	38-123	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	125-128
14966141-7	2004	MAP4K4 interacted preferentially with GTP-bound Rap2 over GDP-bound Rap2 in vitro.	Guanosine Triphosphate	38-41	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	0-6
14966141-7	2004	MAP4K4 interacted preferentially with GTP-bound Rap2 over GDP-bound Rap2 in vitro.	Guanosine Diphosphate	58-61	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	0-6