PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
16132793-1	2005	OBJECTIVE: The aim of this study was to investigate the role of alcohol dehydrogenase type 3 (ADH3), glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) polymorphisms in modifying hepatocellular carcinoma (HCC) risk according to alcohol intake.	Alcohols	64-71	glutathione S-transferase theta 1	Homo sapiens	146-151
16308270-4	2005	Because the toxic effect of various chemicals can be modified by metabolic traits, the study also investigated the influence of the glutathione S-transferases (GSTM1 and GSTT1) on the toxic effect of DMF.	Dimethylformamide	200-203	glutathione S-transferase theta 1	Homo sapiens	170-175
16308270-11	2005	Compared with the low DMF group with GSTT1-positive genotype workers, the odds ratio (adjusted for HBV status) of abnormal liver function test was 12.38, 95% CI=(1.04-146.9) for the high DMF group with GSTT1 null genotype workers.	Dimethylformamide	22-25	glutathione S-transferase theta 1	Homo sapiens	37-42
16308270-11	2005	Compared with the low DMF group with GSTT1-positive genotype workers, the odds ratio (adjusted for HBV status) of abnormal liver function test was 12.38, 95% CI=(1.04-146.9) for the high DMF group with GSTT1 null genotype workers.	Dimethylformamide	187-190	glutathione S-transferase theta 1	Homo sapiens	37-42
16308270-11	2005	Compared with the low DMF group with GSTT1-positive genotype workers, the odds ratio (adjusted for HBV status) of abnormal liver function test was 12.38, 95% CI=(1.04-146.9) for the high DMF group with GSTT1 null genotype workers.	Dimethylformamide	187-190	glutathione S-transferase theta 1	Homo sapiens	202-207
16257343-2	2005	We therefore studied the role of cruciferous vegetables in lung cancer after stratifying by GSTM1 and GSTT1 status, two genes implicated in the elimination of isothiocyanates, the likely chemopreventative compound.	Isothiocyanates	159-174	glutathione S-transferase theta 1	Homo sapiens	102-107
16173971-2	2005	Cellular sensitivity to 1,2:3,4 diepoxybutane was significantly increased in GSTT1 deleted compared with GSTT1 positive cases (median chromosomal breaks 11.1 vs. 8.3, P < 0.01) but there was no effect on clinical manifestations of FA.	diepoxybutane	24-45	glutathione S-transferase theta 1	Homo sapiens	77-82
16173971-2	2005	Cellular sensitivity to 1,2:3,4 diepoxybutane was significantly increased in GSTT1 deleted compared with GSTT1 positive cases (median chromosomal breaks 11.1 vs. 8.3, P < 0.01) but there was no effect on clinical manifestations of FA.	diepoxybutane	24-45	glutathione S-transferase theta 1	Homo sapiens	105-110
16133571-0	2005	The gut fermentation product butyrate, a chemopreventive agent, suppresses glutathione S-transferase theta (hGSTT1) and cell growth more in human colon adenoma (LT97) than tumor (HT29) cells.	Butyrates	29-37	glutathione S-transferase theta 1	Homo sapiens	108-114
16133571-5	2005	Stability of GST-theta (hGSTT1) mRNA was assessed in HT29 cells after inhibition of transcription with actinomycin D.	Dactinomycin	103-116	glutathione S-transferase theta 1	Homo sapiens	24-30
16133571-7	2005	Butyrate did not induce GSTs, but instead reduced hGSTT1 in LT97 and HT29.	Butyrates	0-8	glutathione S-transferase theta 1	Homo sapiens	50-56
16133571-8	2005	CONCLUSIONS: Butyrate has suppressing-agent activities in human colon cells by inhibiting two survival factors, namely hGSTT1 and cell growth, with LT97 more sensitive than HT29.	Butyrates	13-21	glutathione S-transferase theta 1	Homo sapiens	119-125
16536303-1	2005	OBJECTIVE: To study the association between susceptibility to aflatoxin B1 (AFB1)-related hepatocellular carcinoma(HCC) and the null genotypes of detoxication gene gstM1 and gstT1.	Aflatoxin B1	62-74	glutathione S-transferase theta 1	Homo sapiens	174-179
16308270-12	2005	This study indicates that abnormal liver function and chronic liver disease are associated with DMF exposure, and there are more than multiplicative interaction effects on abnormal liver function tests between the DMF exposure and the GSTT1 genotype.	Dimethylformamide	214-217	glutathione S-transferase theta 1	Homo sapiens	235-240
15790493-0	2005	Genotoxicity and metabolism of the source-water contaminant 1,1-dichloropropene: activation by GSTT1-1 and structure-activity considerations.	Water	42-47	glutathione S-transferase theta 1	Homo sapiens	95-102
16161713-9	2005	The limited stratum-specific numbers showed that the exposed workers with the GSTM1-/GSTT1-genotype had nonsignificantly higher frequencies of all the effect parameters than the unexposed workers; this finding indicates that individual susceptibility related to the detoxification of acrylamide and N-methylolacrylamide may have played a role in the observed effect.	Acrylamide	284-294	glutathione S-transferase theta 1	Homo sapiens	85-90
16161713-9	2005	The limited stratum-specific numbers showed that the exposed workers with the GSTM1-/GSTT1-genotype had nonsignificantly higher frequencies of all the effect parameters than the unexposed workers; this finding indicates that individual susceptibility related to the detoxification of acrylamide and N-methylolacrylamide may have played a role in the observed effect.	N-methylolacrylamide	299-319	glutathione S-transferase theta 1	Homo sapiens	85-90
15935803-6	2005	The production rate of S-PMA from benzene in exposed workers with GSTT1 null alleles (24.72+/-32.48 microg/g creatinine/ppm benzene) was significantly lower than that in subjects with the wild type of GSTT1 (59.84+/-47.66 microg/g creatinine/ppm benzene, p<0.0001).	Benzene	34-41	glutathione S-transferase theta 1	Homo sapiens	66-71
15935803-6	2005	The production rate of S-PMA from benzene in exposed workers with GSTT1 null alleles (24.72+/-32.48 microg/g creatinine/ppm benzene) was significantly lower than that in subjects with the wild type of GSTT1 (59.84+/-47.66 microg/g creatinine/ppm benzene, p<0.0001).	Benzene	34-41	glutathione S-transferase theta 1	Homo sapiens	201-206
15935803-6	2005	The production rate of S-PMA from benzene in exposed workers with GSTT1 null alleles (24.72+/-32.48 microg/g creatinine/ppm benzene) was significantly lower than that in subjects with the wild type of GSTT1 (59.84+/-47.66 microg/g creatinine/ppm benzene, p<0.0001).	Creatinine	109-119	glutathione S-transferase theta 1	Homo sapiens	66-71
15935803-6	2005	The production rate of S-PMA from benzene in exposed workers with GSTT1 null alleles (24.72+/-32.48 microg/g creatinine/ppm benzene) was significantly lower than that in subjects with the wild type of GSTT1 (59.84+/-47.66 microg/g creatinine/ppm benzene, p<0.0001).	Benzene	124-131	glutathione S-transferase theta 1	Homo sapiens	66-71
15935803-6	2005	The production rate of S-PMA from benzene in exposed workers with GSTT1 null alleles (24.72+/-32.48 microg/g creatinine/ppm benzene) was significantly lower than that in subjects with the wild type of GSTT1 (59.84+/-47.66 microg/g creatinine/ppm benzene, p<0.0001).	Creatinine	231-241	glutathione S-transferase theta 1	Homo sapiens	66-71
15935803-6	2005	The production rate of S-PMA from benzene in exposed workers with GSTT1 null alleles (24.72+/-32.48 microg/g creatinine/ppm benzene) was significantly lower than that in subjects with the wild type of GSTT1 (59.84+/-47.66 microg/g creatinine/ppm benzene, p<0.0001).	Benzene	124-131	glutathione S-transferase theta 1	Homo sapiens	66-71
15935803-7	2005	Further regression analysis of S-PMA production rate on GSTT1 genotype with adjustment of sex, age, benzene exposure, and cotinine levels indicated that the genotype of GSTT1 plays a critical role in determining the inter-individual variations of S-PMA formation from benzene exposure.	Benzene	100-107	glutathione S-transferase theta 1	Homo sapiens	56-61
15935803-7	2005	Further regression analysis of S-PMA production rate on GSTT1 genotype with adjustment of sex, age, benzene exposure, and cotinine levels indicated that the genotype of GSTT1 plays a critical role in determining the inter-individual variations of S-PMA formation from benzene exposure.	Benzene	100-107	glutathione S-transferase theta 1	Homo sapiens	169-174
15935803-7	2005	Further regression analysis of S-PMA production rate on GSTT1 genotype with adjustment of sex, age, benzene exposure, and cotinine levels indicated that the genotype of GSTT1 plays a critical role in determining the inter-individual variations of S-PMA formation from benzene exposure.	Cotinine	122-130	glutathione S-transferase theta 1	Homo sapiens	56-61
15935803-7	2005	Further regression analysis of S-PMA production rate on GSTT1 genotype with adjustment of sex, age, benzene exposure, and cotinine levels indicated that the genotype of GSTT1 plays a critical role in determining the inter-individual variations of S-PMA formation from benzene exposure.	Cotinine	122-130	glutathione S-transferase theta 1	Homo sapiens	169-174
15935803-7	2005	Further regression analysis of S-PMA production rate on GSTT1 genotype with adjustment of sex, age, benzene exposure, and cotinine levels indicated that the genotype of GSTT1 plays a critical role in determining the inter-individual variations of S-PMA formation from benzene exposure.	Benzene	268-275	glutathione S-transferase theta 1	Homo sapiens	56-61
15935803-7	2005	Further regression analysis of S-PMA production rate on GSTT1 genotype with adjustment of sex, age, benzene exposure, and cotinine levels indicated that the genotype of GSTT1 plays a critical role in determining the inter-individual variations of S-PMA formation from benzene exposure.	Benzene	268-275	glutathione S-transferase theta 1	Homo sapiens	169-174
15935803-8	2005	Therefore, the individual genotype of GSTT1 needs to be identified and considered while using S-PMA as a marker to estimate the personal exposure levels of benzene in future population studies.	Benzene	156-163	glutathione S-transferase theta 1	Homo sapiens	38-43
15790493-0	2005	Genotoxicity and metabolism of the source-water contaminant 1,1-dichloropropene: activation by GSTT1-1 and structure-activity considerations.	1,1-dichloropropene	60-79	glutathione S-transferase theta 1	Homo sapiens	95-102
15748501-8	2005	The genetic polymorphisms of 3 genes (NQO1, GSTT1 and GSTM1) led to declining of detoxifying ability in benzene metabolism, so the individual with NQO1 C609T T/T genotype, GSTT1 null genotype and GSTM1 null genotype is most susceptive to benzene.	Benzene	104-111	glutathione S-transferase theta 1	Homo sapiens	44-49
15668107-9	2005	In this experiment individuals carrying GSTT1 showed lower adduct level increments from ethylene oxide than individuals lacking GSTT1.	Ethylene Oxide	88-102	glutathione S-transferase theta 1	Homo sapiens	40-45
15748501-8	2005	The genetic polymorphisms of 3 genes (NQO1, GSTT1 and GSTM1) led to declining of detoxifying ability in benzene metabolism, so the individual with NQO1 C609T T/T genotype, GSTT1 null genotype and GSTM1 null genotype is most susceptive to benzene.	Benzene	104-111	glutathione S-transferase theta 1	Homo sapiens	172-177
15748501-8	2005	The genetic polymorphisms of 3 genes (NQO1, GSTT1 and GSTM1) led to declining of detoxifying ability in benzene metabolism, so the individual with NQO1 C609T T/T genotype, GSTT1 null genotype and GSTM1 null genotype is most susceptive to benzene.	Benzene	238-245	glutathione S-transferase theta 1	Homo sapiens	44-49
15748501-8	2005	The genetic polymorphisms of 3 genes (NQO1, GSTT1 and GSTM1) led to declining of detoxifying ability in benzene metabolism, so the individual with NQO1 C609T T/T genotype, GSTT1 null genotype and GSTM1 null genotype is most susceptive to benzene.	Benzene	238-245	glutathione S-transferase theta 1	Homo sapiens	172-177
16438295-5	2005	The dose of acrylamide or glycidamide has been measured in blood samples from individuals with defined genotypes for the glutathione transferases GSTT1 and GSTM1 after in vitro incubation with these compounds.	Acrylamide	12-22	glutathione S-transferase theta 1	Homo sapiens	146-151
16438295-5	2005	The dose of acrylamide or glycidamide has been measured in blood samples from individuals with defined genotypes for the glutathione transferases GSTT1 and GSTM1 after in vitro incubation with these compounds.	glycidamide	26-37	glutathione S-transferase theta 1	Homo sapiens	146-151
15256483-5	2004	Therefore, we hypothesized that individuals possessing the low activity genotypes of GSTM1, GSTT1 and/or GSTP1 (i.e. the GSTM1 null, GSTT1 null and GSTP1 AB/BB genotypes, respectively) may exhibit a stronger marine n-3 fatty acid-breast cancer association than their high activity counterparts.	Fatty Acids, Omega-3	215-229	glutathione S-transferase theta 1	Homo sapiens	92-97
15638917-0	2005	Genetic polymorphism of glutathione S-transferase genes (GSTM1, GSTT1 and GSTP1) and susceptibility to prostate cancer in Northern India.	Glutathione	24-35	glutathione S-transferase theta 1	Homo sapiens	64-69
15533900-11	2004	Subjects carrying the GSTT1 wild-type excreted higher concentrations of S-PMA than subjects carrying the null genotype, suggesting that it is a key enzyme in the glutathione conjugation that leads to S-PMA.	Glutathione	162-173	glutathione S-transferase theta 1	Homo sapiens	22-27
15934438-2	2005	Glutathione S-transferase (GST) is involved in the detoxification of ROS and genetic polymorphisms of GSTM1, GSTT1 and GSTP1 are associated with altered enzyme activity.	Reactive Oxygen Species	69-72	glutathione S-transferase theta 1	Homo sapiens	109-114
16521944-4	2005	Very important role in this process is played by S-glutathione transferase M1 (GSTM1) and S-glutathione transferase T1 (GSTT1) which conjugate glutathione with xenobiotics and promote their removal from human body.	Glutathione	51-62	glutathione S-transferase theta 1	Homo sapiens	120-125
16521944-7	2005	The common deletions of GSTM1 and GSTT1 were determined by polymerase chain reaction and agarose gel separation.	Sepharose	89-96	glutathione S-transferase theta 1	Homo sapiens	34-39
15279829-11	2004	Reaction of the dihalo and monohalo HNMs with GSH, possibly GSTT1-1, is a possible mechanism for formation of ultimate mutagenic products.	Glutathione	46-49	glutathione S-transferase theta 1	Homo sapiens	60-67
15298956-0	2004	Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	0-26	glutathione S-transferase theta 1	Homo sapiens	130-135
15298956-0	2004	Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	28-32	glutathione S-transferase theta 1	Homo sapiens	130-135
15338373-0	2004	Genetic analysis of the glutathione s-transferase genes MGST1, GSTM3, GSTT1, and GSTM1 in patients with hereditary pancreatitis.	Glutathione	24-35	glutathione S-transferase theta 1	Homo sapiens	70-75
15764300-2	2004	A preliminary case-control study was conducted to explore the association between genetic polymorphisms of GSTT1, p53 codon 72 and bladder cancer in southern Taiwan, a former high arsenic exposure area.	Arsenic	180-187	glutathione S-transferase theta 1	Homo sapiens	107-112
15213713-2	2004	Functional polymorphisms in DNA-repair genes XPD, ERCC1, XRCC1, XPA, and metabolising genes glutathione S-transferase GSTP1, GSTT1, GSTM1, and thymidylate synthase (TS) were assessed retrospectively in 106 patients with refractory stage IV disease who received 5-FU/oxaliplatin combination chemotherapy, using a polymerase chain reaction-based RFLP technique.	Fluorouracil	261-265	glutathione S-transferase theta 1	Homo sapiens	125-130
15213713-2	2004	Functional polymorphisms in DNA-repair genes XPD, ERCC1, XRCC1, XPA, and metabolising genes glutathione S-transferase GSTP1, GSTT1, GSTM1, and thymidylate synthase (TS) were assessed retrospectively in 106 patients with refractory stage IV disease who received 5-FU/oxaliplatin combination chemotherapy, using a polymerase chain reaction-based RFLP technique.	Oxaliplatin	266-277	glutathione S-transferase theta 1	Homo sapiens	125-130
15036125-0	2004	Influence of GSTT1, mEH, CYP2E1 and RAD51 polymorphisms on diepoxybutane-induced SCE frequency in cultured human lymphocytes.	diepoxybutane	59-72	glutathione S-transferase theta 1	Homo sapiens	13-18
15103050-9	2004	At 1 mM glutathione and 300 microM MeP concentrations, hGSTT1-1 and hGSTA1-1 exhibited the highest O-dealkylation activities: 545.8 and 65.0 nmol/min/mg, respectively.	Glutathione	8-19	glutathione S-transferase theta 1	Homo sapiens	55-63
15256146-3	2004	RESULTS: The frequency of non-null GSTT1 gene in benzene poisoning workers with moderate benzene exposure level was higher than that in cases with lower benzene exposure (68.63% vs 38.00%, OR(adj) = 4.32, 95% CI 1.75 - 10.66, P = 0.002).	Benzene	49-56	glutathione S-transferase theta 1	Homo sapiens	35-40
15256146-3	2004	RESULTS: The frequency of non-null GSTT1 gene in benzene poisoning workers with moderate benzene exposure level was higher than that in cases with lower benzene exposure (68.63% vs 38.00%, OR(adj) = 4.32, 95% CI 1.75 - 10.66, P = 0.002).	Benzene	89-96	glutathione S-transferase theta 1	Homo sapiens	35-40
15256146-3	2004	RESULTS: The frequency of non-null GSTT1 gene in benzene poisoning workers with moderate benzene exposure level was higher than that in cases with lower benzene exposure (68.63% vs 38.00%, OR(adj) = 4.32, 95% CI 1.75 - 10.66, P = 0.002).	Benzene	89-96	glutathione S-transferase theta 1	Homo sapiens	35-40
15256146-6	2004	CONCLUSION: There is interaction between the polymorphism of GSTT1 gene and moderate benzene exposure level; non-null GSTM1 gene and drinking x exposure level increase the risk of occupational chronic benzene poisoning; polymorphism of NQO1 gene C.609 also interacts with drinking, while polymorphism of NQO1 gene and drinking x smoking may further increase the risk of occupational chronic benzene poisoning.	Benzene	85-92	glutathione S-transferase theta 1	Homo sapiens	61-66
15256146-6	2004	CONCLUSION: There is interaction between the polymorphism of GSTT1 gene and moderate benzene exposure level; non-null GSTM1 gene and drinking x exposure level increase the risk of occupational chronic benzene poisoning; polymorphism of NQO1 gene C.609 also interacts with drinking, while polymorphism of NQO1 gene and drinking x smoking may further increase the risk of occupational chronic benzene poisoning.	Benzene	201-208	glutathione S-transferase theta 1	Homo sapiens	61-66
15256146-6	2004	CONCLUSION: There is interaction between the polymorphism of GSTT1 gene and moderate benzene exposure level; non-null GSTM1 gene and drinking x exposure level increase the risk of occupational chronic benzene poisoning; polymorphism of NQO1 gene C.609 also interacts with drinking, while polymorphism of NQO1 gene and drinking x smoking may further increase the risk of occupational chronic benzene poisoning.	Benzene	201-208	glutathione S-transferase theta 1	Homo sapiens	61-66
15033463-1	2004	In order to find the effect of genetic polymorphisms of GSTM1 and GSTT1 on blood pressure of individuals chronically exposed to sulfur compounds, the present study was done.	Sulfur	128-134	glutathione S-transferase theta 1	Homo sapiens	66-71
15093278-10	2004	For instance, in vitro SCE induction by styrene and by epoxide metabolites of 1,3-butadiene is modified by GSTM1 and GSTT1 genotypes--which also influence the excretion of specific mercapturic acids in humans exposed to butadiene and styrene.	Styrene	40-47	glutathione S-transferase theta 1	Homo sapiens	117-122
15093278-10	2004	For instance, in vitro SCE induction by styrene and by epoxide metabolites of 1,3-butadiene is modified by GSTM1 and GSTT1 genotypes--which also influence the excretion of specific mercapturic acids in humans exposed to butadiene and styrene.	Epoxy Compounds	55-62	glutathione S-transferase theta 1	Homo sapiens	117-122
15093278-10	2004	For instance, in vitro SCE induction by styrene and by epoxide metabolites of 1,3-butadiene is modified by GSTM1 and GSTT1 genotypes--which also influence the excretion of specific mercapturic acids in humans exposed to butadiene and styrene.	1,3-butadiene	78-91	glutathione S-transferase theta 1	Homo sapiens	117-122
15093278-10	2004	For instance, in vitro SCE induction by styrene and by epoxide metabolites of 1,3-butadiene is modified by GSTM1 and GSTT1 genotypes--which also influence the excretion of specific mercapturic acids in humans exposed to butadiene and styrene.	Acetylcysteine	181-198	glutathione S-transferase theta 1	Homo sapiens	117-122
15093278-10	2004	For instance, in vitro SCE induction by styrene and by epoxide metabolites of 1,3-butadiene is modified by GSTM1 and GSTT1 genotypes--which also influence the excretion of specific mercapturic acids in humans exposed to butadiene and styrene.	1,3-butadiene	82-91	glutathione S-transferase theta 1	Homo sapiens	117-122
15093278-10	2004	For instance, in vitro SCE induction by styrene and by epoxide metabolites of 1,3-butadiene is modified by GSTM1 and GSTT1 genotypes--which also influence the excretion of specific mercapturic acids in humans exposed to butadiene and styrene.	Styrene	234-241	glutathione S-transferase theta 1	Homo sapiens	117-122
15047208-9	2004	Although the frequency of overall GSTT1 null genotype was significantly lower in cervical carcinoma patients with high-risk HPV infection (OR = 0.3, 95% CI: 0.1-1.0), almost 2-fold increased risk was observed among women with GSTT1 null and Arg/Arg genotype (OR = 1.9, 95% CI: 0.7-5.4).	Arginine	241-244	glutathione S-transferase theta 1	Homo sapiens	34-39
15047208-9	2004	Although the frequency of overall GSTT1 null genotype was significantly lower in cervical carcinoma patients with high-risk HPV infection (OR = 0.3, 95% CI: 0.1-1.0), almost 2-fold increased risk was observed among women with GSTT1 null and Arg/Arg genotype (OR = 1.9, 95% CI: 0.7-5.4).	Arginine	245-248	glutathione S-transferase theta 1	Homo sapiens	34-39
15141365-6	2004	In the present study, we have evaluated the effect of GSTM1, GSTT1, and GSTP1 polymorphisms on the frequency of MN and SCE induced by hydroquinone in human lymphocytes.	hydroquinone	134-146	glutathione S-transferase theta 1	Homo sapiens	61-66
15055296-10	2004	These findings may be explained by reduced detoxification capacity rendered by the altered gene and may be linked with exposure to, for example, heterocyclic amines in the case of NAT2 and endogenously formed ethylene oxide in the case of GSTT1.	Ethylene Oxide	209-223	glutathione S-transferase theta 1	Homo sapiens	239-244
14751678-0	2004	Occupational exposure to styrene: modulation of cytogenetic damage and levels of urinary metabolites of styrene by polymorphisms in genes CYP2E1, EPHX1, GSTM1, GSTT1 and GSTP1.	Styrene	25-32	glutathione S-transferase theta 1	Homo sapiens	160-165
15055296-10	2004	These findings may be explained by reduced detoxification capacity rendered by the altered gene and may be linked with exposure to, for example, heterocyclic amines in the case of NAT2 and endogenously formed ethylene oxide in the case of GSTT1.	heterocyclic amines	145-164	glutathione S-transferase theta 1	Homo sapiens	239-244
12732844-10	2003	CONCLUSIONS: The double null mutation of GSTT1 and GSTM1 might influence troglitazone-associated abnormal increases of liver enzyme levels.	Troglitazone	73-85	glutathione S-transferase theta 1	Homo sapiens	41-46
14644336-6	2003	In vitro sensitivity to the genotoxicity of 1,2:3,4-diepoxybutane, an epoxide metabolite of 1,3-butadiene has clearly been shown to depend on GSTT1 genotype, which has also been implicated to modify, along with GSTM1 genotype, the in vitro genotoxicity of 1,2-epoxy-3-butene, another epoxide metabolite of 1,3-butadiene.	Epoxy Compounds	70-77	glutathione S-transferase theta 1	Homo sapiens	142-147
14644336-6	2003	In vitro sensitivity to the genotoxicity of 1,2:3,4-diepoxybutane, an epoxide metabolite of 1,3-butadiene has clearly been shown to depend on GSTT1 genotype, which has also been implicated to modify, along with GSTM1 genotype, the in vitro genotoxicity of 1,2-epoxy-3-butene, another epoxide metabolite of 1,3-butadiene.	1,3-butadiene	92-105	glutathione S-transferase theta 1	Homo sapiens	142-147
14644336-6	2003	In vitro sensitivity to the genotoxicity of 1,2:3,4-diepoxybutane, an epoxide metabolite of 1,3-butadiene has clearly been shown to depend on GSTT1 genotype, which has also been implicated to modify, along with GSTM1 genotype, the in vitro genotoxicity of 1,2-epoxy-3-butene, another epoxide metabolite of 1,3-butadiene.	3,4-epoxy-1-butene	256-274	glutathione S-transferase theta 1	Homo sapiens	142-147
14644336-6	2003	In vitro sensitivity to the genotoxicity of 1,2:3,4-diepoxybutane, an epoxide metabolite of 1,3-butadiene has clearly been shown to depend on GSTT1 genotype, which has also been implicated to modify, along with GSTM1 genotype, the in vitro genotoxicity of 1,2-epoxy-3-butene, another epoxide metabolite of 1,3-butadiene.	Epoxy Compounds	284-291	glutathione S-transferase theta 1	Homo sapiens	142-147
14644336-6	2003	In vitro sensitivity to the genotoxicity of 1,2:3,4-diepoxybutane, an epoxide metabolite of 1,3-butadiene has clearly been shown to depend on GSTT1 genotype, which has also been implicated to modify, along with GSTM1 genotype, the in vitro genotoxicity of 1,2-epoxy-3-butene, another epoxide metabolite of 1,3-butadiene.	1,3-butadiene	306-319	glutathione S-transferase theta 1	Homo sapiens	142-147
12896903-9	2003	In HT29, butyrate significantly enhanced GSTA1/2 (3.5-fold), GSTM2 (not detectable in controls), GSTP1 (1.5-fold) and GST activity (1.4-fold), but not GSTM1 or GSTT1.	Butyrates	9-17	glutathione S-transferase theta 1	Homo sapiens	160-165
14669454-0	2003	[Manifestation of glutathione S-transferase GSTM1 and GSTT1 in female patients with bleomycin-positive chromosome instability].	Bleomycin	84-93	glutathione S-transferase theta 1	Homo sapiens	54-59
14560658-4	2003	An example of multiplex PCR-CTPP is described for NQO1 C609, GSTM1, and GSTT1.	ctpp	28-32	glutathione S-transferase theta 1	Homo sapiens	72-77
14582249-4	2003	Particularly the role of GSTT1 and GSTM1 polymorphism on the biological indicators of 1,3-butadiene has been evaluated.	1,3-butadiene	86-99	glutathione S-transferase theta 1	Homo sapiens	25-30
12872524-18	2003	The human polymorphic GST catalysing conjugation of halomethanes, dihalomethanes, ethylene oxide and a number of other industrial compounds could be characterised as a class theta enzyme (GSTT1) by means of molecular biology.	halomethanes	52-64	glutathione S-transferase theta 1	Homo sapiens	188-193
12872524-18	2003	The human polymorphic GST catalysing conjugation of halomethanes, dihalomethanes, ethylene oxide and a number of other industrial compounds could be characterised as a class theta enzyme (GSTT1) by means of molecular biology.	dihalomethanes	66-80	glutathione S-transferase theta 1	Homo sapiens	188-193
12872524-18	2003	The human polymorphic GST catalysing conjugation of halomethanes, dihalomethanes, ethylene oxide and a number of other industrial compounds could be characterised as a class theta enzyme (GSTT1) by means of molecular biology.	Ethylene Oxide	82-96	glutathione S-transferase theta 1	Homo sapiens	188-193
12872524-21	2003	Human phenotyping is facilitated by the GST activity towards methyl bromide or ethylene oxide in erythrocytes which is representative of the metabolic GSTT1 competence of the entire organism.	methyl bromide	61-75	glutathione S-transferase theta 1	Homo sapiens	151-156
12872524-21	2003	Human phenotyping is facilitated by the GST activity towards methyl bromide or ethylene oxide in erythrocytes which is representative of the metabolic GSTT1 competence of the entire organism.	Ethylene Oxide	79-93	glutathione S-transferase theta 1	Homo sapiens	151-156
14644336-6	2003	In vitro sensitivity to the genotoxicity of 1,2:3,4-diepoxybutane, an epoxide metabolite of 1,3-butadiene has clearly been shown to depend on GSTT1 genotype, which has also been implicated to modify, along with GSTM1 genotype, the in vitro genotoxicity of 1,2-epoxy-3-butene, another epoxide metabolite of 1,3-butadiene.	diepoxybutane	44-65	glutathione S-transferase theta 1	Homo sapiens	142-147
12739102-1	2003	Vinyl chloride monomer (VCM) is a known human carcinogen, which may be metabolized by cytochrome P450 2E1 (CYP2E1), aldehyde dehydrogenase 2 (ALDH2), and glutathione S-transferase T1 (GSTT1).	Vinyl Chloride	0-14	glutathione S-transferase theta 1	Homo sapiens	154-182
12739102-1	2003	Vinyl chloride monomer (VCM) is a known human carcinogen, which may be metabolized by cytochrome P450 2E1 (CYP2E1), aldehyde dehydrogenase 2 (ALDH2), and glutathione S-transferase T1 (GSTT1).	Vinyl Chloride	0-14	glutathione S-transferase theta 1	Homo sapiens	184-189
12916871-0	2003	Mutant type glutathione S-transferase theta 1 gene homologue to mTOR in myelodysplastic syndrome: possible clinical application of rapamycin.	Sirolimus	131-140	glutathione S-transferase theta 1	Homo sapiens	12-45
12916871-7	2003	Interestingly, rapamycin could induce significant growth inhibition of the stable transformants for mutant type GSTT-1, which was indicative of apoptosis, but not that of those for wild type GSTT-1.	Sirolimus	15-24	glutathione S-transferase theta 1	Homo sapiens	112-118
12916871-8	2003	These results suggest that rapamycin could be included in the therapeutic modality for the patients with MDS who have the mTOR sequences in GSTT-1 gene.	Sirolimus	27-36	glutathione S-transferase theta 1	Homo sapiens	140-146
12807751-5	2003	After adjusting for these factors, we found that the GSTT1 genotypes affected the urinary 1-OHP levels, i.e. the GSTT1 present subjects had approximately 1.5 times the urinary 1-OHP level than the GSTT1 null subjects (P < 0.05).	Oxaliplatin	90-95	glutathione S-transferase theta 1	Homo sapiens	53-58
12807751-5	2003	After adjusting for these factors, we found that the GSTT1 genotypes affected the urinary 1-OHP levels, i.e. the GSTT1 present subjects had approximately 1.5 times the urinary 1-OHP level than the GSTT1 null subjects (P < 0.05).	Oxaliplatin	90-95	glutathione S-transferase theta 1	Homo sapiens	113-118
12807751-5	2003	After adjusting for these factors, we found that the GSTT1 genotypes affected the urinary 1-OHP levels, i.e. the GSTT1 present subjects had approximately 1.5 times the urinary 1-OHP level than the GSTT1 null subjects (P < 0.05).	Oxaliplatin	90-95	glutathione S-transferase theta 1	Homo sapiens	113-118
12807751-5	2003	After adjusting for these factors, we found that the GSTT1 genotypes affected the urinary 1-OHP levels, i.e. the GSTT1 present subjects had approximately 1.5 times the urinary 1-OHP level than the GSTT1 null subjects (P < 0.05).	Oxaliplatin	176-181	glutathione S-transferase theta 1	Homo sapiens	53-58
12807751-5	2003	After adjusting for these factors, we found that the GSTT1 genotypes affected the urinary 1-OHP levels, i.e. the GSTT1 present subjects had approximately 1.5 times the urinary 1-OHP level than the GSTT1 null subjects (P < 0.05).	Oxaliplatin	176-181	glutathione S-transferase theta 1	Homo sapiens	113-118
12807751-5	2003	After adjusting for these factors, we found that the GSTT1 genotypes affected the urinary 1-OHP levels, i.e. the GSTT1 present subjects had approximately 1.5 times the urinary 1-OHP level than the GSTT1 null subjects (P < 0.05).	Oxaliplatin	176-181	glutathione S-transferase theta 1	Homo sapiens	113-118
12807751-6	2003	In the case of the subjects who were also GSTM1 null, this trend became stronger, i.e. the GSTT1 present subjects had approximately 2 times the urinary 1-OHP level (P < 0.01).	Oxaliplatin	152-157	glutathione S-transferase theta 1	Homo sapiens	91-96
12807751-8	2003	Therefore, this study suggests that the GSTT1 genetic polymorphism has the potential to affect the biological monitoring of PAHs with urinary 1-OHP, and might act as a genetic factor in PAH-related toxicity.	Oxaliplatin	142-147	glutathione S-transferase theta 1	Homo sapiens	40-45
12807751-8	2003	Therefore, this study suggests that the GSTT1 genetic polymorphism has the potential to affect the biological monitoring of PAHs with urinary 1-OHP, and might act as a genetic factor in PAH-related toxicity.	Polycyclic Aromatic Hydrocarbons	124-127	glutathione S-transferase theta 1	Homo sapiens	40-45
12851839-3	2003	METHODS: In the present study we analyzed GSTM1 and GSTT1 polymorphisms in the genomic DNA isolated from peripheral blood of patients with ovarian cancer treated with chemotherapy (paclitaxel and cisplatinum) after cytoreductive surgery and assessed its correlation with the clinical outcome of these patients.	Paclitaxel	181-191	glutathione S-transferase theta 1	Homo sapiens	52-57
12563680-2	2003	The glutathione S-transferase (GST) genes GSTM1, GSTT1, and GSTP1 catalyze metabolic pathways for the excretion of reactive oxygen species that may be generated by cellular oxidative stress induced by ultraviolet radiation in sunlight.	Reactive Oxygen Species	115-138	glutathione S-transferase theta 1	Homo sapiens	49-54
12868187-1	2003	The aim of the study was an assessment of various risk factors for nephrotoxicity of ifosfamide (IF) in children taking into account the importance of the concentrations of toxic metabolites of the drug excreted with urine and the polymorphism of genes encoding S-glutathione transferases of mi, pi, and theta classes (GSTM1, GSTP1 and GSTT1).	Ifosfamide	85-95	glutathione S-transferase theta 1	Homo sapiens	336-341
12717779-10	2003	The field survey confirms that styrene exposure is associated with increased DNA damage and indicates a modulating role for GSTM1 and GSTT1 genotypes.	Styrene	31-38	glutathione S-transferase theta 1	Homo sapiens	134-139
12718704-3	2003	This paper introduces triplex PCR-CTPP to simultaneously genotype three functional polymorphisms of carcinogen-detoxifying enzymes, NQO1 C609T, GSTM1 null, and GSTT1 null, all of which are reported to have a significant association with smoking-related cancers.	ctpp	34-38	glutathione S-transferase theta 1	Homo sapiens	160-165
15258326-2	2003	It catalyzes the reduction of glutathione to its thioester; thus, deficiency in GST activity due to homozygous deletion of the GSTT1 gene (null genotype) may play a role in the induction of lung cancer by smoking.	Glutathione	30-41	glutathione S-transferase theta 1	Homo sapiens	127-132
20021156-10	2003	The genotype status of GSTM1 and GSTT1 was successfully determined in all patients by analyzing an aliquot of the same DNA used for the 8-OHdG evaluation.	8-ohdg	136-142	glutathione S-transferase theta 1	Homo sapiens	33-38
12460800-1	2002	Metabolic enzymes involved in benzene activation or detoxification, including NAD(P)H, quinone oxidoreductase 1 (NQO1), cytochrome P450 2E1 (CYP2E1), myeloperoxidase (MPO), glutathione-S-transferase mu-1 (GSTM1), and glutathione-S-transferase theta-1 (GSTT1), were studied for their roles in human susceptibility to benzene poisoning.	Benzene	30-37	glutathione S-transferase theta 1	Homo sapiens	217-250
12460800-0	2002	Association of genetic polymorphisms in CYP2E1, MPO, NQO1, GSTM1, and GSTT1 genes with benzene poisoning.	Benzene	87-94	glutathione S-transferase theta 1	Homo sapiens	70-75
12460800-1	2002	Metabolic enzymes involved in benzene activation or detoxification, including NAD(P)H, quinone oxidoreductase 1 (NQO1), cytochrome P450 2E1 (CYP2E1), myeloperoxidase (MPO), glutathione-S-transferase mu-1 (GSTM1), and glutathione-S-transferase theta-1 (GSTT1), were studied for their roles in human susceptibility to benzene poisoning.	Benzene	30-37	glutathione S-transferase theta 1	Homo sapiens	252-257
12460800-7	2002	Our data also indicated that individuals with CYP2E1 c.-1293 C/C and c.-1293 G/C, and NQO1 c.609 T/T, and GSTT1 null genotypes tended to be more susceptible to benzene toxicity.	Benzene	160-167	glutathione S-transferase theta 1	Homo sapiens	106-111
12460800-8	2002	Our results suggest that the combined effect of polymorphisms in NQO1, CYP2E1, and GSTT1 genes and lifestyle factors might contribute to benzene poisoning.	Benzene	137-144	glutathione S-transferase theta 1	Homo sapiens	83-88
12415426-2	2002	We have developed a routine ex vivo photometric phenotyping procedure based on the determination of bromide release rates from the hGSTT1-1-catalyzed glutathione conjugation of the substrate methyl bromide in EDTA blood samples under standard conditions (1,000 ppm methyl bromide, 10 min incubation).	Bromides	100-107	glutathione S-transferase theta 1	Homo sapiens	131-137
12552997-1	2002	N-acetyltransferase-2 (NAT-2) and Glutathione-S-transferase M1 and T1 (GSTM1 and GSTT1) polymorphism have been implicated in the detoxification of urothelial carcinogens, such as arylamines and polycyclic aromatic hydrocarbons.	aniline	179-189	glutathione S-transferase theta 1	Homo sapiens	81-86
12552997-1	2002	N-acetyltransferase-2 (NAT-2) and Glutathione-S-transferase M1 and T1 (GSTM1 and GSTT1) polymorphism have been implicated in the detoxification of urothelial carcinogens, such as arylamines and polycyclic aromatic hydrocarbons.	Polycyclic Aromatic Hydrocarbons	194-226	glutathione S-transferase theta 1	Homo sapiens	81-86
12415426-2	2002	We have developed a routine ex vivo photometric phenotyping procedure based on the determination of bromide release rates from the hGSTT1-1-catalyzed glutathione conjugation of the substrate methyl bromide in EDTA blood samples under standard conditions (1,000 ppm methyl bromide, 10 min incubation).	Glutathione	150-161	glutathione S-transferase theta 1	Homo sapiens	131-137
12415426-2	2002	We have developed a routine ex vivo photometric phenotyping procedure based on the determination of bromide release rates from the hGSTT1-1-catalyzed glutathione conjugation of the substrate methyl bromide in EDTA blood samples under standard conditions (1,000 ppm methyl bromide, 10 min incubation).	methyl bromide	191-205	glutathione S-transferase theta 1	Homo sapiens	131-137
12415426-2	2002	We have developed a routine ex vivo photometric phenotyping procedure based on the determination of bromide release rates from the hGSTT1-1-catalyzed glutathione conjugation of the substrate methyl bromide in EDTA blood samples under standard conditions (1,000 ppm methyl bromide, 10 min incubation).	Edetic Acid	209-213	glutathione S-transferase theta 1	Homo sapiens	131-137
12415426-2	2002	We have developed a routine ex vivo photometric phenotyping procedure based on the determination of bromide release rates from the hGSTT1-1-catalyzed glutathione conjugation of the substrate methyl bromide in EDTA blood samples under standard conditions (1,000 ppm methyl bromide, 10 min incubation).	methyl bromide	265-279	glutathione S-transferase theta 1	Homo sapiens	131-137
12172927-3	2002	Although CYP and GST enzymes are involved in the activation and detoxification of N-nitrosamines and related compound, studies on the relationship between genetic polymorphisms of CYP2E1, GSTT1, and GSTM1 and the risk of gastric carcinoma (GC) are few, and the results have been conflicting.	n-nitrosamines	82-96	glutathione S-transferase theta 1	Homo sapiens	188-193
12376511-8	2002	Higher THBVal levels were found in subjects with GSTM1 null and GSTT1 null genotypes; borderline influences were also noticed for CYP2E1(G(-35)T).	thbval	7-13	glutathione S-transferase theta 1	Homo sapiens	64-69
12376511-10	2002	A multiple linear regression analysis, where each factor contributed significantly, correlated THBVal levels with smoking, CYP2E1(G(-35)T), GSTT1, and GSTM1 genotypes (r = 0.698).	thbval	95-101	glutathione S-transferase theta 1	Homo sapiens	140-145
14694720-0	2002	[Relation of genetic polymorphism of NQO1 and GSTT1 with risks of chronic benzene poisoning].	Benzene	74-81	glutathione S-transferase theta 1	Homo sapiens	46-51
14694720-1	2002	OBJECTIVE: To explore the relation between genetic polymorphisms of NQO1, GSTT1 and risks of chronic benzene poisoning (BP).	Benzene	101-108	glutathione S-transferase theta 1	Homo sapiens	74-79
14694720-1	2002	OBJECTIVE: To explore the relation between genetic polymorphisms of NQO1, GSTT1 and risks of chronic benzene poisoning (BP).	Benzo(a)pyrene	120-122	glutathione S-transferase theta 1	Homo sapiens	74-79
12055050-0	2002	GSTT1 and CYP2E1 polymorphisms and trihalomethanes in drinking water: effect on childhood leukemia.	Drinking Water	54-68	glutathione S-transferase theta 1	Homo sapiens	0-5
12183419-11	2002	Analyses of combined genotypes suggested an interaction between XRCC1 (Gln/Gln or Arg/Gln) and GSTT1/GSTM1-null/null among women but not among men.	Glutamine	71-74	glutathione S-transferase theta 1	Homo sapiens	95-100
12183419-11	2002	Analyses of combined genotypes suggested an interaction between XRCC1 (Gln/Gln or Arg/Gln) and GSTT1/GSTM1-null/null among women but not among men.	Glutamine	75-78	glutathione S-transferase theta 1	Homo sapiens	95-100
12183419-11	2002	Analyses of combined genotypes suggested an interaction between XRCC1 (Gln/Gln or Arg/Gln) and GSTT1/GSTM1-null/null among women but not among men.	Arginine	82-85	glutathione S-transferase theta 1	Homo sapiens	95-100
12183419-11	2002	Analyses of combined genotypes suggested an interaction between XRCC1 (Gln/Gln or Arg/Gln) and GSTT1/GSTM1-null/null among women but not among men.	Glutamine	75-78	glutathione S-transferase theta 1	Homo sapiens	95-100
12163326-4	2002	The NQO1 and GSTT1 polymorphisms were associated with lung adenocarcinoma risk with adjusted odds ratio of 2.15 for the NQO1-Pro/Pro genotype versus the Ser/Ser genotype and adjusted odds ratio of 1.61 for the GSTT1-null genotype versus the positive genotype, respectively.	Serine	153-156	glutathione S-transferase theta 1	Homo sapiens	13-18
12163326-4	2002	The NQO1 and GSTT1 polymorphisms were associated with lung adenocarcinoma risk with adjusted odds ratio of 2.15 for the NQO1-Pro/Pro genotype versus the Ser/Ser genotype and adjusted odds ratio of 1.61 for the GSTT1-null genotype versus the positive genotype, respectively.	Serine	157-160	glutathione S-transferase theta 1	Homo sapiens	13-18
14992466-8	2002	An increased binomial regression risk ratio = 2.5, 95% confidence interval (CI) 1.5-4.2, of the GSTM1 null genotype for CTE was found in smokers and for the GSTT1 null genotype (binomial regression risk ratio 1.5, 95% CI 1.0-2.0).	1,1,1-trifluoro-2-chloroethane	120-123	glutathione S-transferase theta 1	Homo sapiens	157-162
12055050-2	2002	We included a subset of cases from a population-based case-control study in a case-only study to estimate the interaction odds ratios (IORs) between prenatal and postnatal exposure to THMs and polymorphisms in the GSTT1 and CYP2E1 genes.	Trihalomethanes	184-188	glutathione S-transferase theta 1	Homo sapiens	214-219
12055050-4	2002	The IOR for a postnatal average of total THM above the 95th percentile with GSTT1 null genotype was 9.1 [95% confidence interval (95% CI), 1.4-57.8].	Trihalomethanes	41-44	glutathione S-transferase theta 1	Homo sapiens	76-81
12016165-9	2002	Our results suggest that the concurrent lack of the GSTM1 and GSTT1 genes increases the genotoxic effects of styrene in human cells.	Styrene	109-116	glutathione S-transferase theta 1	Homo sapiens	62-67
12034316-1	2002	The aim of this study was to use DNA adducts levels, detected by 32P-postlabelling, as a biomarker to assess human exposure to polycyclic aromatic hydrocarbons (PAHs) from a coke oven plant and explore the possible association between CYP1A1 MspI, GSTP1, GSTM1 and GSTT1 genotypes, and smoking status on bulky DNA adduct formation.	Polycyclic Aromatic Hydrocarbons	161-165	glutathione S-transferase theta 1	Homo sapiens	265-270
12016165-0	2002	Influence of GSTM1 and GSTT1 genotypes on sister chromatid exchange induction by styrene in cultured human lymphocytes.	Styrene	81-88	glutathione S-transferase theta 1	Homo sapiens	23-28
12016165-2	2002	We previously observed that GSTT1 null genotype was associated with increased induction of sister chromatid exchanges (SCEs) by a metabolite of styrene, styrene-7,8-oxide, in human lymphocyte cultures, while GSTM1 genotype had no effect.	Styrene	144-151	glutathione S-transferase theta 1	Homo sapiens	28-33
12016165-2	2002	We previously observed that GSTT1 null genotype was associated with increased induction of sister chromatid exchanges (SCEs) by a metabolite of styrene, styrene-7,8-oxide, in human lymphocyte cultures, while GSTM1 genotype had no effect.	styrene oxide	153-170	glutathione S-transferase theta 1	Homo sapiens	28-33
12016165-6	2002	In two separate experiments, the mean number of SCEs/cell induced by 1.5 mM styrene was 1.55 times (P = 0.011) or 1.34 times (P = 0.015) higher in subjects lacking both GSTM1 and GSTT1 than in subjects having both genes.	Styrene	76-83	glutathione S-transferase theta 1	Homo sapiens	179-184
12010862-11	2002	Additional analysis revealed that individuals possessing more susceptible XRCC1 Gln-Gln, CYP2E1 c2c2, ALDH2 1-2/2-2, and non-null GSTT1 genotypes were more likely to reveal p53 overexpression.	Glutamine	80-83	glutathione S-transferase theta 1	Homo sapiens	130-135
11927838-2	2002	Here, we extended the study to examine the possible role of N-acetyltransferase (NAT) genotypes in the development of diisocyanate-induced ill effects, both separately and in combination with the previously examined GSTM1, GSTM3, GSTP1 and GSTT1 genotypes.	4,4'-diphenylmethane diisocyanate	118-130	glutathione S-transferase theta 1	Homo sapiens	240-245
11841793-0	2002	The polymorphic human glutathione transferase T1-1, the most efficient glutathione transferase in the denitrosation and inactivation of the anticancer drug 1,3-bis(2-chloroethyl)-1-nitrosourea.	Carmustine	156-192	glutathione S-transferase theta 1	Homo sapiens	22-50
11766168-5	2001	TMA/blood benzene ratio was partially modulated by glutathione S-transferase (GST) genotypes, with significantly higher values in null individuals (GSTM1 and GSTT1 combined).	muconic acid	0-3	glutathione S-transferase theta 1	Homo sapiens	158-163
11760815-0	2001	Dependence of papanicolaou gradings of exfoliated urothelial cells upon GSTM1 and GSTT1 polymorphism in benzidine-exposed workers of the Shanghai dye industry.	benzidine	104-113	glutathione S-transferase theta 1	Homo sapiens	82-87
11641039-0	2001	Effects of genetic polymorphisms of CYP1A1, CYP2E1, GSTM1, and GSTT1 on the urinary levels of 1-hydroxypyrene and 2-naphthol in aircraft maintenance workers.	1-hydroxypyrene	94-109	glutathione S-transferase theta 1	Homo sapiens	63-68
11712598-5	2001	A significantly higher percentage (50%) of Cr workers had both the null GSTM1 and GSTT1 genotype as compared to 10% of the controls (P < 0.01).	Chromium	43-45	glutathione S-transferase theta 1	Homo sapiens	82-87
11757669-0	2001	Polymorphisms of glutathione S-transferase genes (GSTM1, GSTP1 and GSTT1) and bladder cancer susceptibility in the Turkish population.	Glutathione	17-28	glutathione S-transferase theta 1	Homo sapiens	67-72
11535247-2	2001	Previously, an extended haemoglobin adduct monitoring (N-(cyanoethyl)valine and N-(hydroxyethyl)-valine) was performed regarding the glutathione transferases hGSTM1 and hGSTT1 polymorphisms but no influence of hGSTM1 or hGSTT1 polymorphisms on specific adduct levels was found.	n-(cyanoethyl)valine	55-75	glutathione S-transferase theta 1	Homo sapiens	169-175
11535247-7	2001	The study also confirmed the impact of GSTT1 polymorphism on background N-(hydroxyethyl)-valine adduct levels in haemoglobin which are caused by endogenous ethylene oxide.	n-(hydroxyethyl)-valine	72-95	glutathione S-transferase theta 1	Homo sapiens	39-44
11535247-7	2001	The study also confirmed the impact of GSTT1 polymorphism on background N-(hydroxyethyl)-valine adduct levels in haemoglobin which are caused by endogenous ethylene oxide.	Ethylene Oxide	156-170	glutathione S-transferase theta 1	Homo sapiens	39-44
11535248-4	2001	Vitamin C was higher in GSTT1+ compared with GSTT1 null--as was glucose-6-phosphate dehydrogenase activity.	Ascorbic Acid	0-9	glutathione S-transferase theta 1	Homo sapiens	24-29
11535248-4	2001	Vitamin C was higher in GSTT1+ compared with GSTT1 null--as was glucose-6-phosphate dehydrogenase activity.	Ascorbic Acid	0-9	glutathione S-transferase theta 1	Homo sapiens	45-50
11535248-9	2001	In contrast, the link between smoking and oxidised pyrimidines in DNA was seen only in the GSTT1 null group.	Pyrimidines	51-62	glutathione S-transferase theta 1	Homo sapiens	91-96
11600727-10	2001	There was less association between the concentrations of 1-OHP and the GSTM1, GSTP1, or GSTT1 polymorphism.	Oxaliplatin	57-62	glutathione S-transferase theta 1	Homo sapiens	88-93
11725342-11	2001	The best-known example is probably the diepoxybutane sensitivity of GSTT1 null donors.	diepoxybutane	39-52	glutathione S-transferase theta 1	Homo sapiens	68-73
11641039-0	2001	Effects of genetic polymorphisms of CYP1A1, CYP2E1, GSTM1, and GSTT1 on the urinary levels of 1-hydroxypyrene and 2-naphthol in aircraft maintenance workers.	2-naphthol	114-124	glutathione S-transferase theta 1	Homo sapiens	63-68
11511185-3	2001	Activation of 1,2-dihaloethanes (BrCH(2)CH(2)Br, BrCH(2)CH(2)Cl, and ClCH(2)CH(2)Cl) was investigated using two mammalian theta class GSH transferases (rat GST 5-5 and human GST T1) and a bacterial dichloromethane dehalogenase (DM11).	1,2-dihaloethanes	14-31	glutathione S-transferase theta 1	Homo sapiens	174-180
11448648-0	2001	Host determinants of DNA alkylation and DNA repair activity in human colorectal tissue: O(6)-methylguanine levels are associated with GSTT1 genotype and O(6)-alkylguanine-DNA alkyltransferase activity with CYP2D6 genotype.	O-(6)-methylguanine	89-106	glutathione S-transferase theta 1	Homo sapiens	134-139
11511186-15	2001	The halide order appears most important in the dihalomethane conjugation reactions catalyzed by GST 5-5 and less so in GST T1 and DM11, probably due to changes in the rate-limiting steps.	halide	4-10	glutathione S-transferase theta 1	Homo sapiens	119-125
11446825-0	2001	A Bayesian analysis of the influence of GSTT1 polymorphism on the cancer risk estimate for dichloromethane.	Methylene Chloride	91-106	glutathione S-transferase theta 1	Homo sapiens	40-45
11511186-15	2001	The halide order appears most important in the dihalomethane conjugation reactions catalyzed by GST 5-5 and less so in GST T1 and DM11, probably due to changes in the rate-limiting steps.	dihalomethane	47-60	glutathione S-transferase theta 1	Homo sapiens	119-125
11418090-0	2001	Biological monitoring the exposure to polycyclic aromatic hydrocarbons of coke oven workers in relation to smoking and genetic polymorphisms for GSTM1 and GSTT1.	Polycyclic Aromatic Hydrocarbons	38-70	glutathione S-transferase theta 1	Homo sapiens	155-160
11418090-3	2001	OBJECTIVE: This study aimed to assess whether the current exposure to PAH of coke oven workers in a Dutch plant induced biological effects, and to determine if these effects are influenced by tobacco smoking and by genetic polymorphisms for the glutathione S-transferase genes GSTM1 and GSTT1.	Polycyclic Aromatic Hydrocarbons	70-73	glutathione S-transferase theta 1	Homo sapiens	287-292
11418090-3	2001	OBJECTIVE: This study aimed to assess whether the current exposure to PAH of coke oven workers in a Dutch plant induced biological effects, and to determine if these effects are influenced by tobacco smoking and by genetic polymorphisms for the glutathione S-transferase genes GSTM1 and GSTT1.	Glutathione	245-256	glutathione S-transferase theta 1	Homo sapiens	287-292
11470760-6	2001	In addition, the effect of aflatoxin exposure on HCC risk was more pronounced among chronic HBsAg carriers with the GSTT1 null genotype (OR 3.7, 95% CI 1.5-9.3) than those who were non-null (OR 0.9, 95% CI 0.3-2.4).	Aflatoxins	27-36	glutathione S-transferase theta 1	Homo sapiens	116-121
11470760-7	2001	The interaction between serum AFB(1)-albumin adduct level and GSTT1 genotype was statistically significant (P = 0.03).	Aflatoxin B1	30-36	glutathione S-transferase theta 1	Homo sapiens	62-67
11446825-1	2001	The carcinogenicity of dichloromethane (DCM) is related to metabolic activation mediated by glutathione transferase theta 1 (GSTT1), whereas oxidation serves as a detoxification pathway.	Methylene Chloride	23-38	glutathione S-transferase theta 1	Homo sapiens	92-123
11446825-1	2001	The carcinogenicity of dichloromethane (DCM) is related to metabolic activation mediated by glutathione transferase theta 1 (GSTT1), whereas oxidation serves as a detoxification pathway.	Methylene Chloride	23-38	glutathione S-transferase theta 1	Homo sapiens	125-130
11446825-1	2001	The carcinogenicity of dichloromethane (DCM) is related to metabolic activation mediated by glutathione transferase theta 1 (GSTT1), whereas oxidation serves as a detoxification pathway.	Methylene Chloride	40-43	glutathione S-transferase theta 1	Homo sapiens	92-123
11446825-1	2001	The carcinogenicity of dichloromethane (DCM) is related to metabolic activation mediated by glutathione transferase theta 1 (GSTT1), whereas oxidation serves as a detoxification pathway.	Methylene Chloride	40-43	glutathione S-transferase theta 1	Homo sapiens	125-130
11397403-5	2001	While it is clear that lymphocytes from GSTT1 null individuals are more sensitive for the induction of sister chromatid exchanges (SCE) following in vitro exposure to 1,2,3,4-diepoxybutane, there was no such increase in SCE or other biomarkers of genotoxicity in workers exposed to 1-3 p.p.m.	diepoxybutane	167-188	glutathione S-transferase theta 1	Homo sapiens	40-45
11556154-0	2001	Inhibition of the human erythrocytic glutathione-S-transferase T1 (GST T1) by thimerosal.	Thimerosal	78-88	glutathione S-transferase theta 1	Homo sapiens	37-65
11556154-0	2001	Inhibition of the human erythrocytic glutathione-S-transferase T1 (GST T1) by thimerosal.	Thimerosal	78-88	glutathione S-transferase theta 1	Homo sapiens	67-73
11556154-1	2001	We have investigated the interaction of thimerosal, a widely used antiseptic and preservative, with the human erythrocytic GST T1 (glutathione-S-transferase T1).	Thimerosal	40-50	glutathione S-transferase theta 1	Homo sapiens	123-129
11556154-1	2001	We have investigated the interaction of thimerosal, a widely used antiseptic and preservative, with the human erythrocytic GST T1 (glutathione-S-transferase T1).	Thimerosal	40-50	glutathione S-transferase theta 1	Homo sapiens	131-159
11556154-5	2001	For the normal conjugator we have determined a 2.77 mM thimerosal concentration to inhibit 50% of the GST T1 activity.	Thimerosal	55-65	glutathione S-transferase theta 1	Homo sapiens	102-108
11556154-8	2001	Thus, sufficiently high doses of thimerosal may be able to change the phenotypic status of an individual--at least in vitro--by inhibition of the GST T1 enzyme.	Thimerosal	33-43	glutathione S-transferase theta 1	Homo sapiens	146-152
11434510-5	2001	Approximately 50% of the Caucasian population are homozygous for deletions in GSTM1 and approximately 20% are homozygous for deletions in GSTT1, resulting in conjugation deficiency of mutagenic electrophiles to glutathione.	Glutathione	211-222	glutathione S-transferase theta 1	Homo sapiens	138-143
11323399-0	2001	Effects of occupation, lifestyle and genetic polymorphisms of CYP1A1, CYP2E1, GSTM1 and GSTT1 on urinary 1-hydroxypyrene and 2-naphthol concentrations.	2-naphthol	125-135	glutathione S-transferase theta 1	Homo sapiens	88-93
11320155-6	2001	We have studied TSO-induced sister chromatid exchanges (SCEs) in 72 h whole-blood lymphocyte cultures from 24 healthy human donors, representing different combinations of GSTM1 and GSTT1 positive and null genotypes.	stilbene oxide	16-19	glutathione S-transferase theta 1	Homo sapiens	181-186
11352866-2	2001	We examined the effects of glutathione S-transferase T1 (GSTT1) and M1 (GSTM1) genotypes on the levels of N-(2-hydroxyethyl)valine (HEV) adducts in the erythrocytes and sister chromatid exchange (SCE) in lymphocytes from a group of 58 operators of sterilizers that used EtO and nonexposed workers from nine hospitals in the United States and one hospital in Mexico City.	Nitrogen	106-107	glutathione S-transferase theta 1	Homo sapiens	27-55
11352866-2	2001	We examined the effects of glutathione S-transferase T1 (GSTT1) and M1 (GSTM1) genotypes on the levels of N-(2-hydroxyethyl)valine (HEV) adducts in the erythrocytes and sister chromatid exchange (SCE) in lymphocytes from a group of 58 operators of sterilizers that used EtO and nonexposed workers from nine hospitals in the United States and one hospital in Mexico City.	Nitrogen	106-107	glutathione S-transferase theta 1	Homo sapiens	57-62
11352866-2	2001	We examined the effects of glutathione S-transferase T1 (GSTT1) and M1 (GSTM1) genotypes on the levels of N-(2-hydroxyethyl)valine (HEV) adducts in the erythrocytes and sister chromatid exchange (SCE) in lymphocytes from a group of 58 operators of sterilizers that used EtO and nonexposed workers from nine hospitals in the United States and one hospital in Mexico City.	2-hydroxyethylvaline	108-130	glutathione S-transferase theta 1	Homo sapiens	57-62
11352866-2	2001	We examined the effects of glutathione S-transferase T1 (GSTT1) and M1 (GSTM1) genotypes on the levels of N-(2-hydroxyethyl)valine (HEV) adducts in the erythrocytes and sister chromatid exchange (SCE) in lymphocytes from a group of 58 operators of sterilizers that used EtO and nonexposed workers from nine hospitals in the United States and one hospital in Mexico City.	2-hydroxyethylvaline	132-135	glutathione S-transferase theta 1	Homo sapiens	27-55
11352866-2	2001	We examined the effects of glutathione S-transferase T1 (GSTT1) and M1 (GSTM1) genotypes on the levels of N-(2-hydroxyethyl)valine (HEV) adducts in the erythrocytes and sister chromatid exchange (SCE) in lymphocytes from a group of 58 operators of sterilizers that used EtO and nonexposed workers from nine hospitals in the United States and one hospital in Mexico City.	2-hydroxyethylvaline	132-135	glutathione S-transferase theta 1	Homo sapiens	57-62
11352866-7	2001	The inverse SCE-GSTT1 relationship remained unchanged when SCE was further examined in relation to HEV adducts as an indicator of the internal EtO dose.	Ethylene Oxide	143-146	glutathione S-transferase theta 1	Homo sapiens	16-21
11352866-9	2001	These data indicate that the GSTT1-null genotype is associated with increased formation of EtO-hemoglobin adducts in relation to occupational EtO exposure, suggesting that individuals with homozygous deletion of the GSTT1 gene may be more susceptible to the genotoxic effects of ETO: The unexpected finding of decreased SCEs, which is less clear, may be attributed to the nonchemical specificity of this end point and the lack of expression of the GSTT1 enzyme in lymphocytes.	Ethylene Oxide	279-282	glutathione S-transferase theta 1	Homo sapiens	29-34
11352866-9	2001	These data indicate that the GSTT1-null genotype is associated with increased formation of EtO-hemoglobin adducts in relation to occupational EtO exposure, suggesting that individuals with homozygous deletion of the GSTT1 gene may be more susceptible to the genotoxic effects of ETO: The unexpected finding of decreased SCEs, which is less clear, may be attributed to the nonchemical specificity of this end point and the lack of expression of the GSTT1 enzyme in lymphocytes.	Ethylene Oxide	279-282	glutathione S-transferase theta 1	Homo sapiens	216-221
11352866-9	2001	These data indicate that the GSTT1-null genotype is associated with increased formation of EtO-hemoglobin adducts in relation to occupational EtO exposure, suggesting that individuals with homozygous deletion of the GSTT1 gene may be more susceptible to the genotoxic effects of ETO: The unexpected finding of decreased SCEs, which is less clear, may be attributed to the nonchemical specificity of this end point and the lack of expression of the GSTT1 enzyme in lymphocytes.	Ethylene Oxide	279-282	glutathione S-transferase theta 1	Homo sapiens	216-221
11320155-0	2001	Trans-stilbene oxide-induced sister chromatid exchange in cultured human lymphocytes: influence of GSTM1 and GSTT1 genotypes.	stilbene oxide	0-20	glutathione S-transferase theta 1	Homo sapiens	109-114
11323399-0	2001	Effects of occupation, lifestyle and genetic polymorphisms of CYP1A1, CYP2E1, GSTM1 and GSTT1 on urinary 1-hydroxypyrene and 2-naphthol concentrations.	1-hydroxypyrene	105-120	glutathione S-transferase theta 1	Homo sapiens	88-93
11218045-8	2001	There was little influence of known polymorphisms of GSTM1, GSTM3 and GSTP1 upon the activities towards the test substrates, whereas the influence of GSTT1 polymorphism on the activity towads methyl chloride was straightforward.	Methyl Chloride	192-207	glutathione S-transferase theta 1	Homo sapiens	150-155
11305778-0	2001	High-performance liquid chromatography/fluorescence detection of S-methylglutathione formed by glutathione-S-transferase T1 in vitro.	S-methyl glutathione	65-84	glutathione S-transferase theta 1	Homo sapiens	95-123
11305778-1	2001	Glutathione-S-transferase T1 (GSTT1-1) is a major isoenzyme for the biotransformation of halomethanes.	halomethanes	89-101	glutathione S-transferase theta 1	Homo sapiens	0-28
11305778-1	2001	Glutathione-S-transferase T1 (GSTT1-1) is a major isoenzyme for the biotransformation of halomethanes.	halomethanes	89-101	glutathione S-transferase theta 1	Homo sapiens	30-37
11305778-3	2001	Metabolism of the halomethanes via GSTT1-1 yields S-methylglutathione (MeSG).	halomethanes	18-30	glutathione S-transferase theta 1	Homo sapiens	35-42
11305778-3	2001	Metabolism of the halomethanes via GSTT1-1 yields S-methylglutathione (MeSG).	S-methyl glutathione	50-69	glutathione S-transferase theta 1	Homo sapiens	35-42
11305778-3	2001	Metabolism of the halomethanes via GSTT1-1 yields S-methylglutathione (MeSG).	6-mercapto-7-methylguanosine	71-75	glutathione S-transferase theta 1	Homo sapiens	35-42
11018744-15	2000	Thus, the GSTT1-1 genotype is suspected to confer decreased or increased risk of cancer in relation to the source of exposure; in vitro studies, mostly conducted on metabolites of butadiene, confirm the protective action of GSTT1-1, whereas, thus far, experimental studies prove that the increasing risk is limited.	1,3-butadiene	180-189	glutathione S-transferase theta 1	Homo sapiens	224-231
11186134-5	2000	In univariate analysis, homozygous deletion of GSTT1 (null genotype) conferred a 6.7-fold reduction in risk of prednisone poor-response compared to individuals who were either heterozygous or homozygous for GSTT1 [odds ratio (OR) = 0.15, P = 0.071; multivariate odds ratio = 0.18, P = 0.117].	Prednisone	111-121	glutathione S-transferase theta 1	Homo sapiens	47-52
23886278-1	2001	The objective of this study was to test the infiuence of genetic polymorphisms for metabolic enzymes (CYP2E1, mEH, GSTM1 and GSTT1) implicated in the biotransformation of styrene in humans on the interpretation of urinary biomarkers of exposure.	Styrene	171-178	glutathione S-transferase theta 1	Homo sapiens	125-130
11159743-1	2001	The phase II glutathione S-transferases (GSTs) GSTT1, GSTM1 and GSTP1 catalyse glutathione-mediated reduction of exogenous and endogenous electrophiles.	Glutathione	13-24	glutathione S-transferase theta 1	Homo sapiens	47-52
11052546-1	2000	This study investigated whether the association between low level benzene exposure and shortened gestation is modified by two susceptibility genes, CYP1A1 and GSTT1.	Benzene	66-73	glutathione S-transferase theta 1	Homo sapiens	159-164
10794492-11	2000	This contrasts with a recent report of reduced risk of RCC associated with GSTT1 null in a cohort of trichloroethene-exposed workers and suggests that specific chemical exposures alter the effect of GSTT1 on cancer risk.	Trichloroethylene	101-116	glutathione S-transferase theta 1	Homo sapiens	75-80
11085692-2	2000	Glutathione S-transferases M1 and T1 (GSTM1 and GSTT1) conjugate isothiocyanates leading to more rapid elimination.	Isothiocyanates	65-80	glutathione S-transferase theta 1	Homo sapiens	48-53
11085692-8	2000	This protective effect of isothiocyanates was seen primarily among individuals with homozygous deletion of GSTM1 (0.36 [0.20-0.63]) and particularly with deletion of both GSTM1 and GSTT1 (0.28 [0.13-0.57]).	Isothiocyanates	26-41	glutathione S-transferase theta 1	Homo sapiens	181-186
10862521-7	2000	An especially remarkable risk of breast cancer was observed for alcohol-consuming premenopausal women lacking both the GSTM1 and GSTT1 genes (OR = 5.3, 95% CI = 1.0-27.8) compared to those with both of the genes.	Alcohols	64-71	glutathione S-transferase theta 1	Homo sapiens	129-134
11037805-1	2000	The aim of the present study was to investigate how the genetic polymorphism in glutathione transferase T1 (GSTT1) affects the metabolism and disposition of methyl chloride in humans in vivo.	Methyl Chloride	157-172	glutathione S-transferase theta 1	Homo sapiens	108-113
11037805-2	2000	The 24 volunteers (13 males and 11 females) who participated in the study were recruited from a group of 208 individuals previously phenotyped for GSTT1 by measuring the glutathione transferase activity with methyl chloride in lysed erythrocytes ex vivo.	Methyl Chloride	208-223	glutathione S-transferase theta 1	Homo sapiens	147-152
11037805-6	2000	The average net respiratory uptake of methyl chloride was 243, 158, and 44 micromol in individuals with high, intermediate and no GSTT1 activity, respectively.	Methyl Chloride	38-53	glutathione S-transferase theta 1	Homo sapiens	130-135
11037805-10	2000	In conclusion, GSTT1 appears to be the sole determinant of methyl chloride metabolism in humans.	Methyl Chloride	59-74	glutathione S-transferase theta 1	Homo sapiens	15-20
11037805-11	2000	Thus, individuals with nonfunctional GSTT1 entirely lack the capacity to metabolize methyl chloride.	Methyl Chloride	84-99	glutathione S-transferase theta 1	Homo sapiens	37-42
11007341-11	2000	Glutathione S-transferase T1 deficiency in the thimerosal/mercury group (19.8%) was barely elevated versus healthy controls (16.0%) and the "para-compound" group (14.0%).	Thimerosal	47-57	glutathione S-transferase theta 1	Homo sapiens	0-28
11007341-11	2000	Glutathione S-transferase T1 deficiency in the thimerosal/mercury group (19.8%) was barely elevated versus healthy controls (16.0%) and the "para-compound" group (14.0%).	Mercury	58-65	glutathione S-transferase theta 1	Homo sapiens	0-28
10813720-6	2000	The individuals carrying both the arginine/proline genotype of p53 and the null genotype of GSTT1 showed a 3.5-fold increase of cervical carcinoma risk (95% CI, 1.8-7.1) compared with those individuals carrying both the arginine/arginine genotype of p53 and the GSTT1 positive genotype.	Arginine	34-42	glutathione S-transferase theta 1	Homo sapiens	262-267
10813720-6	2000	The individuals carrying both the arginine/proline genotype of p53 and the null genotype of GSTT1 showed a 3.5-fold increase of cervical carcinoma risk (95% CI, 1.8-7.1) compared with those individuals carrying both the arginine/arginine genotype of p53 and the GSTT1 positive genotype.	Arginine	220-228	glutathione S-transferase theta 1	Homo sapiens	92-97
10813720-6	2000	The individuals carrying both the arginine/proline genotype of p53 and the null genotype of GSTT1 showed a 3.5-fold increase of cervical carcinoma risk (95% CI, 1.8-7.1) compared with those individuals carrying both the arginine/arginine genotype of p53 and the GSTT1 positive genotype.	Arginine	220-228	glutathione S-transferase theta 1	Homo sapiens	92-97
10813720-9	2000	CONCLUSIONS: The results of the current study suggested that the arginine/proline genotype of p53, independently or in conjunction with the GSTT1 null genotype, could affect the genetic susceptibility for cervical carcinoma, and HPV positive women carrying both null genotypes of GSTT1 and GSTM1 have an increased risk of cervical carcinoma developing before age 40 years.	Arginine	65-73	glutathione S-transferase theta 1	Homo sapiens	280-285
10813720-9	2000	CONCLUSIONS: The results of the current study suggested that the arginine/proline genotype of p53, independently or in conjunction with the GSTT1 null genotype, could affect the genetic susceptibility for cervical carcinoma, and HPV positive women carrying both null genotypes of GSTT1 and GSTM1 have an increased risk of cervical carcinoma developing before age 40 years.	Proline	74-81	glutathione S-transferase theta 1	Homo sapiens	280-285
10815689-1	2000	Individuals with a homozygous deletion of the glutathione S-transferase theta 1 (GSTT1) gene lack GSTT1 enzymatic detoxification of environmental carcinogens by conjugation with glutathione.	Glutathione	46-57	glutathione S-transferase theta 1	Homo sapiens	81-86
10815689-1	2000	Individuals with a homozygous deletion of the glutathione S-transferase theta 1 (GSTT1) gene lack GSTT1 enzymatic detoxification of environmental carcinogens by conjugation with glutathione.	Glutathione	46-57	glutathione S-transferase theta 1	Homo sapiens	98-103
10794492-11	2000	This contrasts with a recent report of reduced risk of RCC associated with GSTT1 null in a cohort of trichloroethene-exposed workers and suggests that specific chemical exposures alter the effect of GSTT1 on cancer risk.	Trichloroethylene	101-116	glutathione S-transferase theta 1	Homo sapiens	199-204
10666194-0	2000	Polymorphisms within glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia: a case-control study.	Glutathione	21-32	glutathione S-transferase theta 1	Homo sapiens	61-66
10801254-1	2000	BACKGROUND: Glutathione conjugation of tacrine reactive metabolites depends in part on the activity of glutathione-S-transferases (GST), of which two isozymes (GST M1 and GST T1) are polymorphically expressed.	Glutathione	12-23	glutathione S-transferase theta 1	Homo sapiens	171-177
10801254-1	2000	BACKGROUND: Glutathione conjugation of tacrine reactive metabolites depends in part on the activity of glutathione-S-transferases (GST), of which two isozymes (GST M1 and GST T1) are polymorphically expressed.	Tacrine	39-46	glutathione S-transferase theta 1	Homo sapiens	171-177
10607731-1	2000	The modulation of benzo[a]pyrene diolepoxide (BPDE)-DNA adduct levels by polymorphisms in the CYP1A1, GSTM1 and GSTT1 genes was assessed in leukocytes of Caucasian males.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	18-44	glutathione S-transferase theta 1	Homo sapiens	112-117
10667466-10	2000	After controlling for age, gender, education, pack-years of smoking, alcohol drinking, body mass index, H. pylori infection, and fruit and salt intake, the adjusted odds ratio (OR) for GSTT1 and gastric cancer was 2.50 (95% confidence interval (CI), 1.01-6.22).	Alcohols	69-76	glutathione S-transferase theta 1	Homo sapiens	185-190
10667466-10	2000	After controlling for age, gender, education, pack-years of smoking, alcohol drinking, body mass index, H. pylori infection, and fruit and salt intake, the adjusted odds ratio (OR) for GSTT1 and gastric cancer was 2.50 (95% confidence interval (CI), 1.01-6.22).	Salts	139-143	glutathione S-transferase theta 1	Homo sapiens	185-190
10708971-0	2000	The influence of GSTM1 and GSTT1 genotypes on the induction of sister chromatid exchanges and chromosome aberrations by 1,2:3,4-diepoxybutane.	diepoxybutane	120-141	glutathione S-transferase theta 1	Homo sapiens	27-32
10607731-1	2000	The modulation of benzo[a]pyrene diolepoxide (BPDE)-DNA adduct levels by polymorphisms in the CYP1A1, GSTM1 and GSTT1 genes was assessed in leukocytes of Caucasian males.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	46-50	glutathione S-transferase theta 1	Homo sapiens	112-117
11525595-7	2000	The inverse associations between plasma selenium level and AFB1-albumin adducts were statistically significant among those with null genotypes of GSTM1 and GSTT1, but not among the nonnull genotypes.	Selenium	40-48	glutathione S-transferase theta 1	Homo sapiens	156-161
10607731-0	2000	Modulation of benzo[a]pyrene diolepoxide-DNA adduct levels in human white blood cells by CYP1A1, GSTM1 and GSTT1 polymorphism.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	14-40	glutathione S-transferase theta 1	Homo sapiens	107-112
10526210-3	1999	The metabolism of brominated THMs is thought to involve a GSH conjugation reaction leading either to formaldehyde or DNA-reactive intermediates via glutathione S-transferase-theta (GSTT1-1), which is polymorphic in humans.	Trihalomethanes	29-33	glutathione S-transferase theta 1	Homo sapiens	181-188
10650922-0	1999	Differential substrate behaviours of ethylene oxide and propylene oxide towards human glutathione transferase theta hGSTT1-1.	Ethylene Oxide	37-51	glutathione S-transferase theta 1	Homo sapiens	116-124
10650922-0	1999	Differential substrate behaviours of ethylene oxide and propylene oxide towards human glutathione transferase theta hGSTT1-1.	propylene oxide	56-71	glutathione S-transferase theta 1	Homo sapiens	116-124
10650922-1	1999	The transformation of ethylene oxide (EO), propylene oxide (PO) and 1-butylene oxide (1-BuO) by human glutathione transferase theta (hGSTT1-1) was studied comparatively using "conjugator" (GSTT1 + individuals) erythrocyte lysates.	Ethylene Oxide	22-36	glutathione S-transferase theta 1	Homo sapiens	133-141
10650922-1	1999	The transformation of ethylene oxide (EO), propylene oxide (PO) and 1-butylene oxide (1-BuO) by human glutathione transferase theta (hGSTT1-1) was studied comparatively using "conjugator" (GSTT1 + individuals) erythrocyte lysates.	Ethylene Oxide	22-36	glutathione S-transferase theta 1	Homo sapiens	134-139
10650922-1	1999	The transformation of ethylene oxide (EO), propylene oxide (PO) and 1-butylene oxide (1-BuO) by human glutathione transferase theta (hGSTT1-1) was studied comparatively using "conjugator" (GSTT1 + individuals) erythrocyte lysates.	Ethylene Oxide	38-40	glutathione S-transferase theta 1	Homo sapiens	133-141
10650922-1	1999	The transformation of ethylene oxide (EO), propylene oxide (PO) and 1-butylene oxide (1-BuO) by human glutathione transferase theta (hGSTT1-1) was studied comparatively using "conjugator" (GSTT1 + individuals) erythrocyte lysates.	propylene oxide	43-58	glutathione S-transferase theta 1	Homo sapiens	133-141
10650922-1	1999	The transformation of ethylene oxide (EO), propylene oxide (PO) and 1-butylene oxide (1-BuO) by human glutathione transferase theta (hGSTT1-1) was studied comparatively using "conjugator" (GSTT1 + individuals) erythrocyte lysates.	propylene oxide	60-62	glutathione S-transferase theta 1	Homo sapiens	133-141
10650922-1	1999	The transformation of ethylene oxide (EO), propylene oxide (PO) and 1-butylene oxide (1-BuO) by human glutathione transferase theta (hGSTT1-1) was studied comparatively using "conjugator" (GSTT1 + individuals) erythrocyte lysates.	1,2-epoxybutane	68-84	glutathione S-transferase theta 1	Homo sapiens	133-141
10650922-1	1999	The transformation of ethylene oxide (EO), propylene oxide (PO) and 1-butylene oxide (1-BuO) by human glutathione transferase theta (hGSTT1-1) was studied comparatively using "conjugator" (GSTT1 + individuals) erythrocyte lysates.	1,2-epoxybutane	68-84	glutathione S-transferase theta 1	Homo sapiens	134-139
10650922-1	1999	The transformation of ethylene oxide (EO), propylene oxide (PO) and 1-butylene oxide (1-BuO) by human glutathione transferase theta (hGSTT1-1) was studied comparatively using "conjugator" (GSTT1 + individuals) erythrocyte lysates.	1,2-epoxybutane	86-91	glutathione S-transferase theta 1	Homo sapiens	133-141
10650922-1	1999	The transformation of ethylene oxide (EO), propylene oxide (PO) and 1-butylene oxide (1-BuO) by human glutathione transferase theta (hGSTT1-1) was studied comparatively using "conjugator" (GSTT1 + individuals) erythrocyte lysates.	1,2-epoxybutane	86-91	glutathione S-transferase theta 1	Homo sapiens	134-139
10650922-4	1999	This sequence of reactivities of homologous epoxides towards GSTT1-1 contrasts to the sequence observed in homologous alkyl halides (methyl bromide, MBr; ethyl bromide, EtBr; n-propyl bromide, PrBr) where the relative sequence MeBr >> EtBr > PrBr is observed.	Epoxy Compounds	44-52	glutathione S-transferase theta 1	Homo sapiens	61-68
10650922-4	1999	This sequence of reactivities of homologous epoxides towards GSTT1-1 contrasts to the sequence observed in homologous alkyl halides (methyl bromide, MBr; ethyl bromide, EtBr; n-propyl bromide, PrBr) where the relative sequence MeBr >> EtBr > PrBr is observed.	alkyl halides	118-131	glutathione S-transferase theta 1	Homo sapiens	61-68
10650922-4	1999	This sequence of reactivities of homologous epoxides towards GSTT1-1 contrasts to the sequence observed in homologous alkyl halides (methyl bromide, MBr; ethyl bromide, EtBr; n-propyl bromide, PrBr) where the relative sequence MeBr >> EtBr > PrBr is observed.	methyl bromide	133-147	glutathione S-transferase theta 1	Homo sapiens	61-68
10650922-4	1999	This sequence of reactivities of homologous epoxides towards GSTT1-1 contrasts to the sequence observed in homologous alkyl halides (methyl bromide, MBr; ethyl bromide, EtBr; n-propyl bromide, PrBr) where the relative sequence MeBr >> EtBr > PrBr is observed.	bromoethane	134-147	glutathione S-transferase theta 1	Homo sapiens	61-68
10650922-4	1999	This sequence of reactivities of homologous epoxides towards GSTT1-1 contrasts to the sequence observed in homologous alkyl halides (methyl bromide, MBr; ethyl bromide, EtBr; n-propyl bromide, PrBr) where the relative sequence MeBr >> EtBr > PrBr is observed.	1-bromopropane	175-191	glutathione S-transferase theta 1	Homo sapiens	61-68
10650922-4	1999	This sequence of reactivities of homologous epoxides towards GSTT1-1 contrasts to the sequence observed in homologous alkyl halides (methyl bromide, MBr; ethyl bromide, EtBr; n-propyl bromide, PrBr) where the relative sequence MeBr >> EtBr > PrBr is observed.	1-bromopropane	193-197	glutathione S-transferase theta 1	Homo sapiens	61-68
10650922-4	1999	This sequence of reactivities of homologous epoxides towards GSTT1-1 contrasts to the sequence observed in homologous alkyl halides (methyl bromide, MBr; ethyl bromide, EtBr; n-propyl bromide, PrBr) where the relative sequence MeBr >> EtBr > PrBr is observed.	methyl bromide	227-231	glutathione S-transferase theta 1	Homo sapiens	61-68
10650922-4	1999	This sequence of reactivities of homologous epoxides towards GSTT1-1 contrasts to the sequence observed in homologous alkyl halides (methyl bromide, MBr; ethyl bromide, EtBr; n-propyl bromide, PrBr) where the relative sequence MeBr >> EtBr > PrBr is observed.	1-bromopropane	251-255	glutathione S-transferase theta 1	Homo sapiens	61-68
10650922-5	1999	The higher reactivity towards GSTT1-1 of propylene oxide compared to ethylene oxide is consistent with a higher chemical reactivity.	propylene oxide	41-56	glutathione S-transferase theta 1	Homo sapiens	30-37
10526210-3	1999	The metabolism of brominated THMs is thought to involve a GSH conjugation reaction leading either to formaldehyde or DNA-reactive intermediates via glutathione S-transferase-theta (GSTT1-1), which is polymorphic in humans.	Glutathione	58-61	glutathione S-transferase theta 1	Homo sapiens	181-188
10526210-3	1999	The metabolism of brominated THMs is thought to involve a GSH conjugation reaction leading either to formaldehyde or DNA-reactive intermediates via glutathione S-transferase-theta (GSTT1-1), which is polymorphic in humans.	Formaldehyde	101-113	glutathione S-transferase theta 1	Homo sapiens	181-188
10511265-9	1999	On the other hand, 1-OHPG excretion was higher in GSTT1-positive smokers than in GSTT1-deficient smokers.	1-ohpg	19-25	glutathione S-transferase theta 1	Homo sapiens	50-55
10511265-9	1999	On the other hand, 1-OHPG excretion was higher in GSTT1-positive smokers than in GSTT1-deficient smokers.	1-ohpg	19-25	glutathione S-transferase theta 1	Homo sapiens	81-86
10511265-10	1999	It is important to note the variability of individual PAH metabolite excretion due to different GSTM1 and GSTT1 genotypes.	Polycyclic Aromatic Hydrocarbons	54-57	glutathione S-transferase theta 1	Homo sapiens	106-111
10438655-1	1999	The carcinogenic potential of dichloromethane (DCM) has been linked to its metabolism to formaldehyde by glutathione-S-transferase theta 1 (GSTT1).	Methylene Chloride	30-45	glutathione S-transferase theta 1	Homo sapiens	105-138
10473651-12	1999	Such results suggest a model in which exposure to brominated THMs may pose an excess genotoxic risk in GSTT1-1(+) individuals to those organs and tissues that both express this gene and come into direct contact with the brominated THM, such as the colon.	Trihalomethanes	61-65	glutathione S-transferase theta 1	Homo sapiens	103-110
10473651-12	1999	Such results suggest a model in which exposure to brominated THMs may pose an excess genotoxic risk in GSTT1-1(+) individuals to those organs and tissues that both express this gene and come into direct contact with the brominated THM, such as the colon.	Trihalomethanes	61-64	glutathione S-transferase theta 1	Homo sapiens	103-110
10438655-1	1999	The carcinogenic potential of dichloromethane (DCM) has been linked to its metabolism to formaldehyde by glutathione-S-transferase theta 1 (GSTT1).	Methylene Chloride	30-45	glutathione S-transferase theta 1	Homo sapiens	140-145
10438655-1	1999	The carcinogenic potential of dichloromethane (DCM) has been linked to its metabolism to formaldehyde by glutathione-S-transferase theta 1 (GSTT1).	Formaldehyde	89-101	glutathione S-transferase theta 1	Homo sapiens	105-138
10438655-1	1999	The carcinogenic potential of dichloromethane (DCM) has been linked to its metabolism to formaldehyde by glutathione-S-transferase theta 1 (GSTT1).	Formaldehyde	89-101	glutathione S-transferase theta 1	Homo sapiens	140-145
10571654-9	1999	Based on this short review we conclude that (i) BPDE-DNA adduct levels resulting from "at risk" genotype combinations may serve as markers to identify most susceptible individuals; (ii) in Indian betel quid/tobacco chewers, the null genotypes of GSTM1 and GSTT1 greatly increased the risk for developing oral leukoplakia.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	48-52	glutathione S-transferase theta 1	Homo sapiens	256-261
10463383-0	1999	Haemoglobin adducts of acrylonitrile and ethylene oxide in acrylonitrile workers, dependent on polymorphisms of the glutathione transferases GSTT1 and GSTM1.	Acrylonitrile	23-36	glutathione S-transferase theta 1	Homo sapiens	141-146
10463383-0	1999	Haemoglobin adducts of acrylonitrile and ethylene oxide in acrylonitrile workers, dependent on polymorphisms of the glutathione transferases GSTT1 and GSTM1.	Ethylene Oxide	41-55	glutathione S-transferase theta 1	Homo sapiens	141-146
10463383-0	1999	Haemoglobin adducts of acrylonitrile and ethylene oxide in acrylonitrile workers, dependent on polymorphisms of the glutathione transferases GSTT1 and GSTM1.	Acrylonitrile	59-72	glutathione S-transferase theta 1	Homo sapiens	141-146
10463383-14	1999	The coincidence with known differences in rates of background sister chromatid exchange between GSTT1- and GSTT1 + persons suggests that the lower ethylene oxide (EO) detoxification rate in GSTT1- persons, indicated by elevated blood protein hydroxyethyl adduct levels, leads to an increased genotoxic effect of the physiological EO background.	Ethylene Oxide	147-161	glutathione S-transferase theta 1	Homo sapiens	96-101
10463383-14	1999	The coincidence with known differences in rates of background sister chromatid exchange between GSTT1- and GSTT1 + persons suggests that the lower ethylene oxide (EO) detoxification rate in GSTT1- persons, indicated by elevated blood protein hydroxyethyl adduct levels, leads to an increased genotoxic effect of the physiological EO background.	Ethylene Oxide	147-161	glutathione S-transferase theta 1	Homo sapiens	107-112
10463383-14	1999	The coincidence with known differences in rates of background sister chromatid exchange between GSTT1- and GSTT1 + persons suggests that the lower ethylene oxide (EO) detoxification rate in GSTT1- persons, indicated by elevated blood protein hydroxyethyl adduct levels, leads to an increased genotoxic effect of the physiological EO background.	Ethylene Oxide	147-161	glutathione S-transferase theta 1	Homo sapiens	107-112
10463383-14	1999	The coincidence with known differences in rates of background sister chromatid exchange between GSTT1- and GSTT1 + persons suggests that the lower ethylene oxide (EO) detoxification rate in GSTT1- persons, indicated by elevated blood protein hydroxyethyl adduct levels, leads to an increased genotoxic effect of the physiological EO background.	Ethylene Oxide	163-165	glutathione S-transferase theta 1	Homo sapiens	107-112
10463383-14	1999	The coincidence with known differences in rates of background sister chromatid exchange between GSTT1- and GSTT1 + persons suggests that the lower ethylene oxide (EO) detoxification rate in GSTT1- persons, indicated by elevated blood protein hydroxyethyl adduct levels, leads to an increased genotoxic effect of the physiological EO background.	Ethylene Oxide	163-165	glutathione S-transferase theta 1	Homo sapiens	107-112
10207629-4	1999	The probability of having CaP was increased in men who had nondeleted (functional) genotypes at GSTT1 (odds ratio, 1.83; 95% confidence interval, 1.19-2.80) but not GSTM1 (odds ratio, 1.07; 95% confidence interval, 0.74-1.55).	cap	26-29	glutathione S-transferase theta 1	Homo sapiens	96-101
10350187-2	1999	We found that individuals with genotypes positive for both GST T1 and GST M1 showed the highest prevalence of low WBC [odds ratio (OR) = 4.67, P = 0.046, 95% confidence interval (CI) = 1.02-24.15] when the benzene exposure was high.	Benzene	206-213	glutathione S-transferase theta 1	Homo sapiens	59-76
10023062-1	1999	Induction of sister chromatid exchanges (SCEs) by 1,2-epoxy-3-butene (monoepoxybutene, MEB), an epoxide metabolite of 1,3-butadiene, in human whole-blood lymphocyte cultures has previously been observed to depend on the glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) genotype of the blood donor.	3,4-epoxy-1-butene	50-68	glutathione S-transferase theta 1	Homo sapiens	265-270
10023062-1	1999	Induction of sister chromatid exchanges (SCEs) by 1,2-epoxy-3-butene (monoepoxybutene, MEB), an epoxide metabolite of 1,3-butadiene, in human whole-blood lymphocyte cultures has previously been observed to depend on the glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) genotype of the blood donor.	3,4-epoxy-1-butene	70-85	glutathione S-transferase theta 1	Homo sapiens	265-270
9918129-1	1998	Although some blood parameters have been suggested to modulate in-vitro induction of sister chromatid exchanges by 1,2:3,4-diepoxybutane (DEB), a metabolite of 1,3-butadiene, the increased sensitivity has largely been assigned to a homozygous deletion of glutathione S-transferase T1 gene (GSTT1 null genotype).	diepoxybutane	115-136	glutathione S-transferase theta 1	Homo sapiens	255-283
9950079-0	1998	Determination of glutathione transferase (GSTT1-1) activities in different tissues based on formation of radioactive metabolites using 35S-glutathione.	35s-glutathione	135-150	glutathione S-transferase theta 1	Homo sapiens	42-49
9950079-1	1998	A new system has been developed to determine enzyme activities of glutathione transferase theta (GSTT1-1) based on radiometric product detection resulting from the enzymic reaction of methyl chloride with 35S-labelled glutathione.	Methyl Chloride	184-199	glutathione S-transferase theta 1	Homo sapiens	97-104
9950079-1	1998	A new system has been developed to determine enzyme activities of glutathione transferase theta (GSTT1-1) based on radiometric product detection resulting from the enzymic reaction of methyl chloride with 35S-labelled glutathione.	Sulfur-35	205-208	glutathione S-transferase theta 1	Homo sapiens	97-104
9950079-1	1998	A new system has been developed to determine enzyme activities of glutathione transferase theta (GSTT1-1) based on radiometric product detection resulting from the enzymic reaction of methyl chloride with 35S-labelled glutathione.	Glutathione	66-77	glutathione S-transferase theta 1	Homo sapiens	97-104
9918129-1	1998	Although some blood parameters have been suggested to modulate in-vitro induction of sister chromatid exchanges by 1,2:3,4-diepoxybutane (DEB), a metabolite of 1,3-butadiene, the increased sensitivity has largely been assigned to a homozygous deletion of glutathione S-transferase T1 gene (GSTT1 null genotype).	diepoxybutane	115-136	glutathione S-transferase theta 1	Homo sapiens	290-295
9918129-1	1998	Although some blood parameters have been suggested to modulate in-vitro induction of sister chromatid exchanges by 1,2:3,4-diepoxybutane (DEB), a metabolite of 1,3-butadiene, the increased sensitivity has largely been assigned to a homozygous deletion of glutathione S-transferase T1 gene (GSTT1 null genotype).	diepoxybutane	138-141	glutathione S-transferase theta 1	Homo sapiens	255-283
9918129-1	1998	Although some blood parameters have been suggested to modulate in-vitro induction of sister chromatid exchanges by 1,2:3,4-diepoxybutane (DEB), a metabolite of 1,3-butadiene, the increased sensitivity has largely been assigned to a homozygous deletion of glutathione S-transferase T1 gene (GSTT1 null genotype).	diepoxybutane	138-141	glutathione S-transferase theta 1	Homo sapiens	290-295
9829702-5	1998	These include the conserved Theta class residues Arg 107, Trp 115, and the conserved GSTT1 subclass residue His 176.	Histidine	108-111	glutathione S-transferase theta 1	Homo sapiens	85-90
9794803-13	1998	It is concluded that the induction of GSTT1 by dietary components and its localization within cells are important factors that should be considered when assessing the risk dihaloalkanes pose to human health.	dihaloalkanes	172-185	glutathione S-transferase theta 1	Homo sapiens	38-43
9285043-0	1997	Influence of polymorphisms of GSTM1 and GSTT1 for risk of renal cell cancer in workers with long-term high occupational exposure to trichloroethene.	Trichloroethylene	132-147	glutathione S-transferase theta 1	Homo sapiens	40-45
9851677-0	1998	Species differences in the glutathione transferase GSTT1-1 activity towards the model substrates methyl chloride and dichloromethane in liver and kidney.	methyl chloride and dichloromethane	97-132	glutathione S-transferase theta 1	Homo sapiens	51-58
9851677-1	1998	Glutathione transferase (GST) GSTT1-1 is involved in the biotransformation of several chemicals widely used in industry, such as butadiene and dichloro methane DCM.	1,3-butadiene	129-138	glutathione S-transferase theta 1	Homo sapiens	30-37
9851677-1	1998	Glutathione transferase (GST) GSTT1-1 is involved in the biotransformation of several chemicals widely used in industry, such as butadiene and dichloro methane DCM.	dichloro methane dcm	143-163	glutathione S-transferase theta 1	Homo sapiens	30-37
9851677-2	1998	The polymorphic hGSTT1-1 may well play a role in the development of kidney tumours after high and long-term occupational exposure against trichloroethylene.	Trichloroethylene	138-155	glutathione S-transferase theta 1	Homo sapiens	16-24
9851677-5	1998	In addition GSTT1-1 activity towards MC and DCM was determined in human erythrocytes.	Methyl Chloride	37-39	glutathione S-transferase theta 1	Homo sapiens	12-19
9851677-5	1998	In addition GSTT1-1 activity towards MC and DCM was determined in human erythrocytes.	dcm	44-47	glutathione S-transferase theta 1	Homo sapiens	12-19
9851677-9	1998	GSTT1-1 activity towards MC was two to seven-times higher in liver cytosol than in kidney cytosol.	Methyl Chloride	25-27	glutathione S-transferase theta 1	Homo sapiens	0-7
9438048-4	1998	We also sought to investigate whether the glutathione S-transferase class theta gene (GSTT1) affects individual susceptibility to cytogenetic damage induced by in vivo exposure to benzene or in vitro exposure to diepoxybutane.	Benzene	180-187	glutathione S-transferase theta 1	Homo sapiens	86-91
9438048-4	1998	We also sought to investigate whether the glutathione S-transferase class theta gene (GSTT1) affects individual susceptibility to cytogenetic damage induced by in vivo exposure to benzene or in vitro exposure to diepoxybutane.	diepoxybutane	212-225	glutathione S-transferase theta 1	Homo sapiens	86-91
9438048-9	1998	A significant benzene-GSTT1 interaction was found in nonsmokers (P < 0.05).	Benzene	14-21	glutathione S-transferase theta 1	Homo sapiens	22-27
9438048-10	1998	Our study suggests that GSTT1 is an important determinant of heterogeneity in individual susceptibility to chromosomal damage associated with exposure to benzene.	Benzene	154-161	glutathione S-transferase theta 1	Homo sapiens	24-29
9498293-1	1998	The influence of glutathione S-transferase T1 (GSTT1) genotype on the genotoxicity of 1,2-epoxy-3-butene (MEB), a metabolite of 1,3-butadiene, was assessed by the analysis of sister chromatid exchanges (SCEs) in 72-h human whole-blood lymphocyte cultures.	3,4-epoxy-1-butene	86-104	glutathione S-transferase theta 1	Homo sapiens	17-45
9498293-1	1998	The influence of glutathione S-transferase T1 (GSTT1) genotype on the genotoxicity of 1,2-epoxy-3-butene (MEB), a metabolite of 1,3-butadiene, was assessed by the analysis of sister chromatid exchanges (SCEs) in 72-h human whole-blood lymphocyte cultures.	3,4-epoxy-1-butene	86-104	glutathione S-transferase theta 1	Homo sapiens	47-52
9539016-7	1998	From all biomarkers the effect of GSTM1 and N-acetyl transferase 2 was seen in coke oven workers on mutagenicity of urine and of glutathione S-transferase T1 on the chromosomal aberrations in subjects from 1,3-butadiene monomer production units.	1,3-butadiene	206-219	glutathione S-transferase theta 1	Homo sapiens	129-157
9654239-0	1998	Influence of GSTT1 genotype on sister chromatid exchange induction by styrene-7,8-oxide in cultured human lymphocytes.	styrene oxide	70-87	glutathione S-transferase theta 1	Homo sapiens	13-18
9654239-8	1998	Although glutathione conjugation is considered a minor metabolic pathway for SO in vivo, the high GSTT1 activity in erythrocytes may be important locally and might affect the level of genotoxic damage observed in peripheral lymphocytes of styrene-exposed reinforced plastics workers.	Styrene	239-246	glutathione S-transferase theta 1	Homo sapiens	98-103
9654239-9	1998	The GSTT1 polymorphism could also influence the urinary excretion of SO-specific mercapturic acids.	Acetylcysteine	81-98	glutathione S-transferase theta 1	Homo sapiens	4-9
10026993-11	1998	In individuals with the GSTT1-0 genotype more chromosomal aberrations and sister chromatid exchanges (SCEs) were observed after exposure to 1,3-butadiene or various haloalkanes or haloalkenes.	1,3-butadiene	140-153	glutathione S-transferase theta 1	Homo sapiens	24-29
10026993-11	1998	In individuals with the GSTT1-0 genotype more chromosomal aberrations and sister chromatid exchanges (SCEs) were observed after exposure to 1,3-butadiene or various haloalkanes or haloalkenes.	haloalkanes	165-176	glutathione S-transferase theta 1	Homo sapiens	24-29
10026993-11	1998	In individuals with the GSTT1-0 genotype more chromosomal aberrations and sister chromatid exchanges (SCEs) were observed after exposure to 1,3-butadiene or various haloalkanes or haloalkenes.	haloalkenes	180-191	glutathione S-transferase theta 1	Homo sapiens	24-29
9379921-0	1997	GSTT1-dependent induction of centromere-negative and -positive micronuclei by 1,2:3,4-diepoxybutane in cultured human lymphocytes.	diepoxybutane	78-99	glutathione S-transferase theta 1	Homo sapiens	0-5
9379921-1	1997	The role of the glutathione S-transferase T1 gene (GSTT1) in determining genotoxic response to 1,2:3,4-diepoxybutane (DEB), an epoxide metabolite of 1,3-butadiene, was studied by analysis of micronuclei (MN) in cultured human lymphocytes using the cytokinesis block method.	diepoxybutane	95-116	glutathione S-transferase theta 1	Homo sapiens	16-44
9379921-1	1997	The role of the glutathione S-transferase T1 gene (GSTT1) in determining genotoxic response to 1,2:3,4-diepoxybutane (DEB), an epoxide metabolite of 1,3-butadiene, was studied by analysis of micronuclei (MN) in cultured human lymphocytes using the cytokinesis block method.	diepoxybutane	95-116	glutathione S-transferase theta 1	Homo sapiens	51-56
9379921-1	1997	The role of the glutathione S-transferase T1 gene (GSTT1) in determining genotoxic response to 1,2:3,4-diepoxybutane (DEB), an epoxide metabolite of 1,3-butadiene, was studied by analysis of micronuclei (MN) in cultured human lymphocytes using the cytokinesis block method.	diepoxybutane	118-121	glutathione S-transferase theta 1	Homo sapiens	16-44
9379921-1	1997	The role of the glutathione S-transferase T1 gene (GSTT1) in determining genotoxic response to 1,2:3,4-diepoxybutane (DEB), an epoxide metabolite of 1,3-butadiene, was studied by analysis of micronuclei (MN) in cultured human lymphocytes using the cytokinesis block method.	diepoxybutane	118-121	glutathione S-transferase theta 1	Homo sapiens	51-56
9379921-1	1997	The role of the glutathione S-transferase T1 gene (GSTT1) in determining genotoxic response to 1,2:3,4-diepoxybutane (DEB), an epoxide metabolite of 1,3-butadiene, was studied by analysis of micronuclei (MN) in cultured human lymphocytes using the cytokinesis block method.	Epoxy Compounds	127-134	glutathione S-transferase theta 1	Homo sapiens	16-44
9379921-1	1997	The role of the glutathione S-transferase T1 gene (GSTT1) in determining genotoxic response to 1,2:3,4-diepoxybutane (DEB), an epoxide metabolite of 1,3-butadiene, was studied by analysis of micronuclei (MN) in cultured human lymphocytes using the cytokinesis block method.	Epoxy Compounds	127-134	glutathione S-transferase theta 1	Homo sapiens	51-56
9379921-1	1997	The role of the glutathione S-transferase T1 gene (GSTT1) in determining genotoxic response to 1,2:3,4-diepoxybutane (DEB), an epoxide metabolite of 1,3-butadiene, was studied by analysis of micronuclei (MN) in cultured human lymphocytes using the cytokinesis block method.	1,3-butadiene	149-162	glutathione S-transferase theta 1	Homo sapiens	16-44
9379921-1	1997	The role of the glutathione S-transferase T1 gene (GSTT1) in determining genotoxic response to 1,2:3,4-diepoxybutane (DEB), an epoxide metabolite of 1,3-butadiene, was studied by analysis of micronuclei (MN) in cultured human lymphocytes using the cytokinesis block method.	1,3-butadiene	149-162	glutathione S-transferase theta 1	Homo sapiens	51-56
9241666-0	1997	Glutathione S-transferase theta genetic polymorphism might influence tacrine hepatotoxicity in Alzheimer"s patients.	Tacrine	69-76	glutathione S-transferase theta 1	Homo sapiens	0-31
9826084-17	1998	CONCLUSIONS: This result is in accordance with the finding that ethylene oxide is a substrate for GSTT1 but not for GSTM1.	Ethylene Oxide	64-78	glutathione S-transferase theta 1	Homo sapiens	98-103
9826084-18	1998	In addition, this study demonstrates a clear influence of genetically determined GSTT1 status on biological effects, e.g., protein adduct formation after non-occupational ethylene oxide exposure.	Ethylene Oxide	171-185	glutathione S-transferase theta 1	Homo sapiens	81-86
10022746-1	1998	Glutathione S-transferase GSTM1, GSTM3 and GSTT1 and cytochrome P450 CYP2D6, CYP1A1 and CYP2E1 loci are susceptibility candidates for cancers of the upper aerodigestive tract because putatively protective and risk genotypes have been identified from studies in other diseases associated with alcohol and tobacco consumption.	Alcohols	292-299	glutathione S-transferase theta 1	Homo sapiens	43-48
9511178-1	1998	Deficiencies of the glutathione transferase isoenzymes GSTM1-1 and GSTT1-1 have been shown to be risk modifiers in a number of different cancers but there have been no similar studies with GSTP1-1, the only member of the Pi class of glutathione S-transferases expressed in humans.	Glutathione	20-31	glutathione S-transferase theta 1	Homo sapiens	67-74
9434735-1	1997	Recombinant human theta class glutathione transferase T1-1 has been heterologously expressed in Escherichia coli and a simple purification method involving immobilized ferric ion affinity chromatography and Orange A dye chromatography is described.	Ferric enterobactin ion	168-174	glutathione S-transferase theta 1	Homo sapiens	30-58
9434735-3	1997	In addition to 1,2-epoxy-3-(4-nitrophenoxy)propane, the substrate used previously to monitor the enzyme, human glutathione transferase T1-1 has activity with the naturally occurring phenethylisothiocyanate and also displays glutathione peroxidase activity with cumene hydroperoxide.	1,2-epoxy-3-(p-nitrophenoxy)propane	15-50	glutathione S-transferase theta 1	Homo sapiens	111-139
9434735-3	1997	In addition to 1,2-epoxy-3-(4-nitrophenoxy)propane, the substrate used previously to monitor the enzyme, human glutathione transferase T1-1 has activity with the naturally occurring phenethylisothiocyanate and also displays glutathione peroxidase activity with cumene hydroperoxide.	phenethyl isothiocyanate	182-205	glutathione S-transferase theta 1	Homo sapiens	111-139
9434735-3	1997	In addition to 1,2-epoxy-3-(4-nitrophenoxy)propane, the substrate used previously to monitor the enzyme, human glutathione transferase T1-1 has activity with the naturally occurring phenethylisothiocyanate and also displays glutathione peroxidase activity with cumene hydroperoxide.	cumene hydroperoxide	261-281	glutathione S-transferase theta 1	Homo sapiens	111-139
9307035-2	1997	The cDNA encoding human glutathione S-transferase (GST) T1 has been expressed as two recombinant forms in Escherichia coli that could be purified by affinity chromatography on either IgG-Sepharose or nickel-agarose; one form of the transferase was synthesized from the pALP 1 expression vector as a Staphylococcus aureus protein A fusion, whereas the other form was synthesized from the pET-20b expression vector as a C-terminal polyhistidine-tagged recombinant.	Sepharose	187-196	glutathione S-transferase theta 1	Homo sapiens	24-58
9307035-2	1997	The cDNA encoding human glutathione S-transferase (GST) T1 has been expressed as two recombinant forms in Escherichia coli that could be purified by affinity chromatography on either IgG-Sepharose or nickel-agarose; one form of the transferase was synthesized from the pALP 1 expression vector as a Staphylococcus aureus protein A fusion, whereas the other form was synthesized from the pET-20b expression vector as a C-terminal polyhistidine-tagged recombinant.	Nickel	200-206	glutathione S-transferase theta 1	Homo sapiens	24-58
9307035-2	1997	The cDNA encoding human glutathione S-transferase (GST) T1 has been expressed as two recombinant forms in Escherichia coli that could be purified by affinity chromatography on either IgG-Sepharose or nickel-agarose; one form of the transferase was synthesized from the pALP 1 expression vector as a Staphylococcus aureus protein A fusion, whereas the other form was synthesized from the pET-20b expression vector as a C-terminal polyhistidine-tagged recombinant.	Sepharose	207-214	glutathione S-transferase theta 1	Homo sapiens	24-58
9307035-2	1997	The cDNA encoding human glutathione S-transferase (GST) T1 has been expressed as two recombinant forms in Escherichia coli that could be purified by affinity chromatography on either IgG-Sepharose or nickel-agarose; one form of the transferase was synthesized from the pALP 1 expression vector as a Staphylococcus aureus protein A fusion, whereas the other form was synthesized from the pET-20b expression vector as a C-terminal polyhistidine-tagged recombinant.	polyhistidine	429-442	glutathione S-transferase theta 1	Homo sapiens	24-58
8671741-0	1996	Influence of erythrocyte glutathione S-transferase T1 on sister chromatid exchanges induced by diepoxybutane in cultured human lymphocytes.	diepoxybutane	95-108	glutathione S-transferase theta 1	Homo sapiens	25-53
8980697-0	1996	Induction of sister chromatid exchange by 3,4-expoxybutane-1,2-diol in cultured human lymphocytes of different GSTT1 and GSTM1 genotypes.	3,4-expoxybutane-1,2-diol	42-67	glutathione S-transferase theta 1	Homo sapiens	111-116
8980697-1	1996	The induction of sister chromatid exchanges (SCEs) by a 48-h treatment with 3,4-epoxybutane-1,2-diol (EBD), a metabolite of 1,3-butadiene, was studied in whole-blood lymphocyte cultures of 22 human donors with known genotypes of two polymorphic glutathione S-transferases (GSTs), GSTT1 and GSTM1.	3,4-epoxybutane-1,2-diol	76-100	glutathione S-transferase theta 1	Homo sapiens	280-285
8799324-1	1996	A high activity glutathione S-transferase T1-1 (GSTT1-1) towards dichloromethane was isolated from human liver cytosol and purified to homogenity in 18.5% yield with a purification factor of 4400-fold.	Glutathione	16-27	glutathione S-transferase theta 1	Homo sapiens	48-55
8799324-1	1996	A high activity glutathione S-transferase T1-1 (GSTT1-1) towards dichloromethane was isolated from human liver cytosol and purified to homogenity in 18.5% yield with a purification factor of 4400-fold.	Methylene Chloride	65-80	glutathione S-transferase theta 1	Homo sapiens	48-55
8799324-3	1996	The purified GSTT1-1-s were homo-dimeric enzymes with a subunit M1 value 25,300 and pI 6 64, as confirmed by SDS-PAGE, IEF and Western blot analysis.	Sodium Dodecyl Sulfate	109-112	glutathione S-transferase theta 1	Homo sapiens	13-20
9064289-1	1996	The recently discovered human class theta glutathione S-transferase T1-1 (GSTT1-1) is responsible for the GSH-dependent detoxification of naturally occurring monohalomethanes.	Glutathione	42-53	glutathione S-transferase theta 1	Homo sapiens	74-81
8569364-0	1996	Increased risk for myelodysplastic syndromes in individuals with glutathione transferase theta 1 (GSTT1) gene defect.	Glutathione	65-76	glutathione S-transferase theta 1	Homo sapiens	98-103
8704864-2	1996	To examine the influence of the polymorphism of glutathione-S-transferase theta (GSTT1) on the neurotoxicity of methyl bromide.	methyl bromide	112-126	glutathione S-transferase theta 1	Homo sapiens	48-79
8704864-2	1996	To examine the influence of the polymorphism of glutathione-S-transferase theta (GSTT1) on the neurotoxicity of methyl bromide.	methyl bromide	112-126	glutathione S-transferase theta 1	Homo sapiens	81-86
9064289-1	1996	The recently discovered human class theta glutathione S-transferase T1-1 (GSTT1-1) is responsible for the GSH-dependent detoxification of naturally occurring monohalomethanes.	Glutathione	106-109	glutathione S-transferase theta 1	Homo sapiens	74-81
9064289-1	1996	The recently discovered human class theta glutathione S-transferase T1-1 (GSTT1-1) is responsible for the GSH-dependent detoxification of naturally occurring monohalomethanes.	monohalomethanes	158-174	glutathione S-transferase theta 1	Homo sapiens	74-81
8524342-6	1995	Recent work has further demonstrated that cultured lymphocytes from the approximately 20% of the Caucasian population that lack the glutathione S-transferase class theta gene (GSTT1) are relatively sensitive to the induction of cytogenetic damage by butadiene metabolites.	Glutathione	132-143	glutathione S-transferase theta 1	Homo sapiens	176-181
8852702-5	1996	The GSTT1-1 phenotype was determined by measuring the erythrocyte conjugating activity towards methyl chloride using a gas chromatographic assay.	Methyl Chloride	95-110	glutathione S-transferase theta 1	Homo sapiens	4-11
8831906-3	1996	Although the presence or absence of the enzyme activity in human red blood cells is parallel with the polymorphism of the human GST T1 gene, the new GST theta in red blood cells may differ from the known GST T1-1 enzyme from other tissues in terms of substrate specificity, since established GST T1-1 substrates [1,2-epoxy-3-(p-nitro-phenoxy)propane and p-nitro-benzyl chloride] are not metabolized.	1,2-epoxy-3-(p-nitrophenoxy)propane	313-349	glutathione S-transferase theta 1	Homo sapiens	128-134
8831906-3	1996	Although the presence or absence of the enzyme activity in human red blood cells is parallel with the polymorphism of the human GST T1 gene, the new GST theta in red blood cells may differ from the known GST T1-1 enzyme from other tissues in terms of substrate specificity, since established GST T1-1 substrates [1,2-epoxy-3-(p-nitro-phenoxy)propane and p-nitro-benzyl chloride] are not metabolized.	4-nitrobenzyl chloride	354-377	glutathione S-transferase theta 1	Homo sapiens	128-134
8565128-5	1996	Mutagenicity of EDB, BDE, CH2Br2, epibromohydrin and 1,3-dichloroacetone was higher in the S.typhimurium TA1535 expressing GSTT1-1 than in the control strain.	Ethylene Dibromide	16-19	glutathione S-transferase theta 1	Homo sapiens	123-128
8565128-5	1996	Mutagenicity of EDB, BDE, CH2Br2, epibromohydrin and 1,3-dichloroacetone was higher in the S.typhimurium TA1535 expressing GSTT1-1 than in the control strain.	methylene bromide	26-32	glutathione S-transferase theta 1	Homo sapiens	123-128
8565128-5	1996	Mutagenicity of EDB, BDE, CH2Br2, epibromohydrin and 1,3-dichloroacetone was higher in the S.typhimurium TA1535 expressing GSTT1-1 than in the control strain.	Epibromohydrin	34-48	glutathione S-transferase theta 1	Homo sapiens	123-128
8565128-5	1996	Mutagenicity of EDB, BDE, CH2Br2, epibromohydrin and 1,3-dichloroacetone was higher in the S.typhimurium TA1535 expressing GSTT1-1 than in the control strain.	1,3-dichloroacetone	53-72	glutathione S-transferase theta 1	Homo sapiens	123-128
8524342-6	1995	Recent work has further demonstrated that cultured lymphocytes from the approximately 20% of the Caucasian population that lack the glutathione S-transferase class theta gene (GSTT1) are relatively sensitive to the induction of cytogenetic damage by butadiene metabolites.	1,3-butadiene	250-259	glutathione S-transferase theta 1	Homo sapiens	176-181
33804102-3	2021	METHODS: We conducted a multivariate analysis involving 177 subjects to determine the association between paraben concentrations and birth outcomes in mothers with GST mu 1 (GSTM1) and GST theta 1 (GSTT1) polymorphisms from 2017 to 2019.	Parabens	106-113	glutathione S-transferase theta 1	Homo sapiens	185-196
7606200-10	1995	Individuals who carry a homozygous deletion of the GSTT1 gene may be at increased risk for genotoxic damage from environmental or occupational 1,3-butadiene exposures.	1,3-butadiene	143-156	glutathione S-transferase theta 1	Homo sapiens	51-56
8526747-1	1995	Polymorphism of glutathione S-transferase theta (GSTT1) modulates the toxicity of halogenated alkanes and epoxides in humans.	Alkanes	94-101	glutathione S-transferase theta 1	Homo sapiens	16-47
8526747-1	1995	Polymorphism of glutathione S-transferase theta (GSTT1) modulates the toxicity of halogenated alkanes and epoxides in humans.	Alkanes	94-101	glutathione S-transferase theta 1	Homo sapiens	49-54
8526747-1	1995	Polymorphism of glutathione S-transferase theta (GSTT1) modulates the toxicity of halogenated alkanes and epoxides in humans.	Epoxy Compounds	106-114	glutathione S-transferase theta 1	Homo sapiens	16-47
8526747-1	1995	Polymorphism of glutathione S-transferase theta (GSTT1) modulates the toxicity of halogenated alkanes and epoxides in humans.	Epoxy Compounds	106-114	glutathione S-transferase theta 1	Homo sapiens	49-54
8526747-9	1995	Since ethylene oxide is a proven substrate of GSTT1, the detoxification of this epoxide arising from endogenous ethylene may modulate SCE background rates.	Ethylene Oxide	6-20	glutathione S-transferase theta 1	Homo sapiens	46-51
8526747-9	1995	Since ethylene oxide is a proven substrate of GSTT1, the detoxification of this epoxide arising from endogenous ethylene may modulate SCE background rates.	Epoxy Compounds	80-87	glutathione S-transferase theta 1	Homo sapiens	46-51
8526747-9	1995	Since ethylene oxide is a proven substrate of GSTT1, the detoxification of this epoxide arising from endogenous ethylene may modulate SCE background rates.	ethylene	6-14	glutathione S-transferase theta 1	Homo sapiens	46-51
8198545-6	1994	The GSTT1+ phenotype can catalyse the glutathione conjugation of dichloromethane, a metabolic pathway which has been shown to be mutagenic in Salmonella typhimurium mutagenicity tester strains and is believed to be responsible for carcinogenicity of dichloromethane in the mouse.	Glutathione	38-49	glutathione S-transferase theta 1	Homo sapiens	4-9
8198545-6	1994	The GSTT1+ phenotype can catalyse the glutathione conjugation of dichloromethane, a metabolic pathway which has been shown to be mutagenic in Salmonella typhimurium mutagenicity tester strains and is believed to be responsible for carcinogenicity of dichloromethane in the mouse.	Methylene Chloride	65-80	glutathione S-transferase theta 1	Homo sapiens	4-9
8198545-6	1994	The GSTT1+ phenotype can catalyse the glutathione conjugation of dichloromethane, a metabolic pathway which has been shown to be mutagenic in Salmonella typhimurium mutagenicity tester strains and is believed to be responsible for carcinogenicity of dichloromethane in the mouse.	Methylene Chloride	250-265	glutathione S-transferase theta 1	Homo sapiens	4-9
8198545-8	1994	Characterization of the GSTT1 polymorphism will thus enable a more accurate assessment of human health risk from synthetic halomethanes and other industrial chemicals.	halomethanes	123-135	glutathione S-transferase theta 1	Homo sapiens	24-29
33804102-8	2021	We found positive relationships of maternal exposure to methyl parabens with birth weight in both mothers with GSTM1 and GSTT1-null genotypes.	methylparaben	56-71	glutathione S-transferase theta 1	Homo sapiens	121-126
7485742-2	1995	The absence of glutathione S-transferases mu (GSTM1) and theta (GSTT1) results in decreased detoxification of carcinogens, for example, chemicals in cigarette smoke.	Glutathione	15-26	glutathione S-transferase theta 1	Homo sapiens	64-69
7788840-0	1995	Role of GSTT1 and GSTM1 genotypes in determining individual sensitivity to sister chromatid exchange induction by diepoxybutane in cultured human lymphocytes.	diepoxybutane	114-127	glutathione S-transferase theta 1	Homo sapiens	8-13
7788840-8	1995	A significant (P < 0.05) negative correlation (r = -0.65 at 5 microM, r = -0.56 at 2 microM) was obtained in the GSTT1 positive donors between DEB-induced individual SCE frequency and RBC GSTT1 activity, measured by formaldehyde formation from dichloromethane; the GSTT1 null individuals showed no GSTT1 activity.	Formaldehyde	219-231	glutathione S-transferase theta 1	Homo sapiens	116-121
7788840-8	1995	A significant (P < 0.05) negative correlation (r = -0.65 at 5 microM, r = -0.56 at 2 microM) was obtained in the GSTT1 positive donors between DEB-induced individual SCE frequency and RBC GSTT1 activity, measured by formaldehyde formation from dichloromethane; the GSTT1 null individuals showed no GSTT1 activity.	Methylene Chloride	247-262	glutathione S-transferase theta 1	Homo sapiens	116-121
33804102-4	2021	Furthermore, we determined the interactive effect between paraben levels and GSTM1/GSTT1 polymorphisms using regression analysis, in addition to a generalized linear model after stratifying GSTM1/GSTT1 genotype into three categories.	Parabens	58-65	glutathione S-transferase theta 1	Homo sapiens	83-88
34453679-7	2022	The metal-gene interaction showed positive correlation between GSTT1 null genotype and Pb and Cd levels (beta = 0.11; p = 0.02 and beta = 0.10; p = 0.01, respectively).	Metals	4-9	glutathione S-transferase theta 1	Homo sapiens	63-68
34499222-1	2022	PURPOSE: This study aimed to retrospectively evaluate the genetic association of null variants of glutathione S-transferases GSTM1 and GSTT1 with relapse incidence in children with hematological malignancies (HMs) undergoing busulfan (BU)- containing allogeneic hematopoietic stem cell transplantation (HSCT) and to assess the impact of these variants on BU-induced cytotoxicity on the immortalized lymphoblastoid cell lines (LCLs) and tumor THP1 GST gene-edited cell models.	Glutathione	98-109	glutathione S-transferase theta 1	Homo sapiens	135-140
34499222-1	2022	PURPOSE: This study aimed to retrospectively evaluate the genetic association of null variants of glutathione S-transferases GSTM1 and GSTT1 with relapse incidence in children with hematological malignancies (HMs) undergoing busulfan (BU)- containing allogeneic hematopoietic stem cell transplantation (HSCT) and to assess the impact of these variants on BU-induced cytotoxicity on the immortalized lymphoblastoid cell lines (LCLs) and tumor THP1 GST gene-edited cell models.	Busulfan	225-233	glutathione S-transferase theta 1	Homo sapiens	135-140
34499222-1	2022	PURPOSE: This study aimed to retrospectively evaluate the genetic association of null variants of glutathione S-transferases GSTM1 and GSTT1 with relapse incidence in children with hematological malignancies (HMs) undergoing busulfan (BU)- containing allogeneic hematopoietic stem cell transplantation (HSCT) and to assess the impact of these variants on BU-induced cytotoxicity on the immortalized lymphoblastoid cell lines (LCLs) and tumor THP1 GST gene-edited cell models.	Busulfan	235-237	glutathione S-transferase theta 1	Homo sapiens	135-140
34499222-1	2022	PURPOSE: This study aimed to retrospectively evaluate the genetic association of null variants of glutathione S-transferases GSTM1 and GSTT1 with relapse incidence in children with hematological malignancies (HMs) undergoing busulfan (BU)- containing allogeneic hematopoietic stem cell transplantation (HSCT) and to assess the impact of these variants on BU-induced cytotoxicity on the immortalized lymphoblastoid cell lines (LCLs) and tumor THP1 GST gene-edited cell models.	Busulfan	355-357	glutathione S-transferase theta 1	Homo sapiens	135-140
34499222-6	2022	BU-induced cell death preferentially in THP1GSTM1(non-null) and LCLsGSTM1(non-null) as shown by decreased viability, increased necrosis and levels of the oxidized form of glutathione compared to null cells, while GSTT1 non-null cells showed increased baseline proliferation.	Busulfan	0-2	glutathione S-transferase theta 1	Homo sapiens	213-218
34453679-7	2022	The metal-gene interaction showed positive correlation between GSTT1 null genotype and Pb and Cd levels (beta = 0.11; p = 0.02 and beta = 0.10; p = 0.01, respectively).	Lead	87-89	glutathione S-transferase theta 1	Homo sapiens	63-68
34453679-7	2022	The metal-gene interaction showed positive correlation between GSTT1 null genotype and Pb and Cd levels (beta = 0.11; p = 0.02 and beta = 0.10; p = 0.01, respectively).	Cadmium	94-96	glutathione S-transferase theta 1	Homo sapiens	63-68
34453679-10	2022	Further, the combined effect of GSTP1 Ile/Val with GSTT1 null genotype was more pronounced and showed an increased risk of susceptibility to Pb toxicity (OR = 11.7; 95% CI: 1.36-102.1, p = 0.02).	Lead	141-143	glutathione S-transferase theta 1	Homo sapiens	51-56
34453679-11	2022	In summary, this study suggests that GSTT1 null and GSTP1 Ile/Val genotypes are the main genetic factors, and individual and specific combinations of GSTP1 Ile/Val with GSTM1 and GSTT1 GST polymorphisms are associated with susceptibility to Pb toxicity.	Lead	241-243	glutathione S-transferase theta 1	Homo sapiens	37-42
34453679-11	2022	In summary, this study suggests that GSTT1 null and GSTP1 Ile/Val genotypes are the main genetic factors, and individual and specific combinations of GSTP1 Ile/Val with GSTM1 and GSTT1 GST polymorphisms are associated with susceptibility to Pb toxicity.	Lead	241-243	glutathione S-transferase theta 1	Homo sapiens	179-184
34766662-9	2022	GMDR revealed a significant interaction between GSTT1 and LL55 genotype.	gmdr	0-4	glutathione S-transferase theta 1	Homo sapiens	48-53
34992428-1	2021	Purpose: Glutathione S-transferases (GSTT1 and GSTM1) are instrumental in detoxification process of activated carcinogens.	Glutathione	9-20	glutathione S-transferase theta 1	Homo sapiens	37-42
34965566-7	2021	It wasfound that in children with BA the tendency to frequency of the deletion variant of the GSTT1 and GSTM1 genes incomparison with children without bronchial and pulmonary pathology was increased.	Barium	34-36	glutathione S-transferase theta 1	Homo sapiens	94-99
34965566-14	2021	One of the leading mechanisms, due to which there is a realization of hereditary predisposition tobronchial asthma in children living under constant intake of radionuclides with a long half-life, is the polymorphismof certain glutathione-S-transferase genes, namely, GSTT1, GSTM1 and A313G gene deletion polymorphism and GSTP1gene polymorphism.	Radioisotopes	159-172	glutathione S-transferase theta 1	Homo sapiens	267-272
32892263-0	2021	Interaction of Blood Manganese Concentrations with GSTT1 in Relation to Autism Spectrum Disorder in Jamaican Children.	Manganese	21-30	glutathione S-transferase theta 1	Homo sapiens	51-56
34535163-0	2021	Up-regulation of GSTT1 in serous ovarian cancer associated with resistance to TAXOL / carboplatin.	Paclitaxel	78-83	glutathione S-transferase theta 1	Homo sapiens	17-22
34535163-0	2021	Up-regulation of GSTT1 in serous ovarian cancer associated with resistance to TAXOL / carboplatin.	Carboplatin	86-97	glutathione S-transferase theta 1	Homo sapiens	17-22
34535163-6	2021	Meanwhile, GSTT1 expression was also significantly upregulated in the SOC patient tissues after taxol treatment, indicating this upregulation was physiologically relevant to chemotherapy.	Paclitaxel	96-101	glutathione S-transferase theta 1	Homo sapiens	11-16
34437496-0	2021	Formaldehyde in Hospitals Induces Oxidative Stress: The Role of GSTT1 and GSTM1 Polymorphisms.	Formaldehyde	0-12	glutathione S-transferase theta 1	Homo sapiens	64-69
34437496-8	2021	In the formalin-employers group the MDA level was significantly higher in GSTT1 Null (p = 0.038), GSTM1 Null (p = 0.031), and CYP1A1 exon 7 mutation carrier (p = 0.008) workers, compared to the wild type subjects.	Formaldehyde	7-15	glutathione S-transferase theta 1	Homo sapiens	74-79
34295994-9	2021	Furthermore, some polymorphisms on NQO1, GSTT1, GSTM1, MPO, and CYP2E1, among other genes, showed a statistically significant relationship with an increased risk of developing at least one of these effects on benzene-exposed workers.	Benzene	209-216	glutathione S-transferase theta 1	Homo sapiens	41-46
34437496-8	2021	In the formalin-employers group the MDA level was significantly higher in GSTT1 Null (p = 0.038), GSTM1 Null (p = 0.031), and CYP1A1 exon 7 mutation carrier (p = 0.008) workers, compared to the wild type subjects.	Malondialdehyde	36-39	glutathione S-transferase theta 1	Homo sapiens	74-79
34754473-3	2021	We sought to examine the association between prenatal PAH exposure and infantile allergic diseases in 6-month-old infants, and how maternal glutathione S-transferase M1 (GSTM1) or T1 (GSTT1) polymorphism affects the association between prenatal PAH exposure and allergic diseases in the Mothers and Children"s Environmental Health (MOCEH) study.	Polycyclic Aromatic Hydrocarbons	245-248	glutathione S-transferase theta 1	Homo sapiens	184-189
34754473-9	2021	The increased risk of infantile allergic diseases associated with urinary 1-OHP during the early period of pregnancy was limited to the maternal GSTT1 null type (OR: 2.69; 95% CI: 1.17, 6.21, by one log-transformed unit of 1-OHP mug/g creatinine); however, the Relative Excess Risk due to Interaction was not statistically significant.	Oxaliplatin	74-79	glutathione S-transferase theta 1	Homo sapiens	145-150
34754473-9	2021	The increased risk of infantile allergic diseases associated with urinary 1-OHP during the early period of pregnancy was limited to the maternal GSTT1 null type (OR: 2.69; 95% CI: 1.17, 6.21, by one log-transformed unit of 1-OHP mug/g creatinine); however, the Relative Excess Risk due to Interaction was not statistically significant.	Oxaliplatin	223-228	glutathione S-transferase theta 1	Homo sapiens	145-150
34754473-9	2021	The increased risk of infantile allergic diseases associated with urinary 1-OHP during the early period of pregnancy was limited to the maternal GSTT1 null type (OR: 2.69; 95% CI: 1.17, 6.21, by one log-transformed unit of 1-OHP mug/g creatinine); however, the Relative Excess Risk due to Interaction was not statistically significant.	Creatinine	235-245	glutathione S-transferase theta 1	Homo sapiens	145-150
34754473-10	2021	Conclusions: The present study found that infantile allergic diseases could be affected by intrauterine PAH exposure, particularly in the early prenatal period and the risk was limited to the maternal GSTT1 null type.	Polycyclic Aromatic Hydrocarbons	104-107	glutathione S-transferase theta 1	Homo sapiens	201-206
35614607-1	2022	OBJECTIVE: To assess the association of single nucleotide polymorphisms in fatty acid binding protein-2 (rs1799883) and glutathione S-transferase pi (rs1695) genes with presence/absence of glutathione S-transferase mu and glutathione S-transferase theta genes in type 2 diabetes.	Glutathione	120-131	glutathione S-transferase theta 1	Homo sapiens	222-253
35621716-4	2022	Deletion polymorphisms of GSTM1 and GSTT1, members of the GST family, are common in humans and are presumed to be associated with cisplatin-induced hearing impairment.	Cisplatin	130-139	glutathione S-transferase theta 1	Homo sapiens	36-41
35621716-5	2022	However, the specific roles of GSTM1 and GSTT1 in cisplatin ototoxicity are not completely clear.	Cisplatin	50-59	glutathione S-transferase theta 1	Homo sapiens	41-46
35605733-2	2022	We aimed to evaluate the associations between serum concentrations of 18 OCPs and semen quality among 387 Chinese men, and further to examine the modifying effects by genetic polymorphisms in cytochrome P450 (CYP2E1) and glutathione S-transferase (GSTT1).	ocps	73-77	glutathione S-transferase theta 1	Homo sapiens	248-253
35605733-10	2022	Our results suggested that CYP2E1 and GSTT1 polymorphisms may modify the effects of OCP exposures on semen quality.	5,10,15,20-tetra(3,5-(nido-carboranylmethyl)phenyl)porphyrin	84-87	glutathione S-transferase theta 1	Homo sapiens	38-43
35527244-9	2022	Whereas, homozygous GSTP1 and GSTT1 null genotype is significantly higher only among nilotinib non-responders.	nilotinib	85-94	glutathione S-transferase theta 1	Homo sapiens	30-35
35426585-5	2022	Genetic variants in MTR, PCYT1A, ASS1, SLC 25A13, GSTM1, GSTT1, SUMO1 BHMT1, and BHMT2 are being reported to be linked with CL/P risk.	Phosphorus	127-128	glutathione S-transferase theta 1	Homo sapiens	57-62
35313604-1	2022	Purpose: Glutathione S-transferases (GSTT1 and GSTM1) detoxify various endogenous and exogenous compounds and provide cytoprotective role against reactive species.	Glutathione	9-20	glutathione S-transferase theta 1	Homo sapiens	37-42
35186174-0	2022	Association of GSTM1 and GSTT1 Null Genotypes with Toluene Diisocyanate-Induced Asthma.	Toluene 2,4-Diisocyanate	51-71	glutathione S-transferase theta 1	Homo sapiens	25-30
32772315-0	2021	GSTM1 and GSTT1 Null Genotype Polymorphisms and Susceptibility to Arsenic Poisoning: a Meta-analysis.	Arsenic	66-73	glutathione S-transferase theta 1	Homo sapiens	10-15
33544514-8	2021	The interaction between GSTT1 null polymorphism and asbestos exposure decreased the MM risk (OR = 0.17; 95% CI = 0.03-0.85; p = 0.031).	Asbestos	52-60	glutathione S-transferase theta 1	Homo sapiens	24-29
33871746-4	2021	The study aimed to investigate metal concentrations in dust, particulate matter and urine of exposed workers and correlate with oxidative stress and glutathione S-transferases genotypes (GSTM1 and GSTT1) that play a role in detoxification of metals in humans.	Metals	31-36	glutathione S-transferase theta 1	Homo sapiens	197-202
33871746-4	2021	The study aimed to investigate metal concentrations in dust, particulate matter and urine of exposed workers and correlate with oxidative stress and glutathione S-transferases genotypes (GSTM1 and GSTT1) that play a role in detoxification of metals in humans.	Glutathione	149-160	glutathione S-transferase theta 1	Homo sapiens	197-202
33443393-0	2021	The Relationship Between GSTT1, GSTM1, GSTO1, GSTP1 and MTHFR Gene Polymorphisms and DNA Damage of BRCA1 and BRCA2 Genes in Arsenic-Exposed Workers.	Arsenic	124-131	glutathione S-transferase theta 1	Homo sapiens	25-30
33709282-3	2021	This study reports, the influence of GSTP1*B and GSTT1/GSTM1null polymorphisms in response to imatinib in CML patients in a Brazilian population.	Imatinib Mesylate	94-102	glutathione S-transferase theta 1	Homo sapiens	49-54
33443393-5	2021	CONCLUSIONS: Our findings suggest that the DNA damage levels of BRCA1 and BRCA2 genes may modulate by genetic variations of GSTT1 and GSTO1 when individuals are exposed to carcinogens, such as arsenic.	Arsenic	193-200	glutathione S-transferase theta 1	Homo sapiens	124-129
33745084-20	2021	We believed the deletion GSTT1null/GSTM1null may contribute to the increased of the oxidative stress in SLE patients while carriers of the mutant SOD2 47CT/TT allele may have greater oxidative stress due to structural change in the protein and decreased H2O2 production.	Hydrogen Peroxide	254-258	glutathione S-transferase theta 1	Homo sapiens	25-30
33600611-2	2022	Glutathione S-transferase (GSTT1) is involved in activation of detoxification reactions and catalysis of chemicals conjugation with glutathione.	Glutathione	0-11	glutathione S-transferase theta 1	Homo sapiens	27-32
33600611-2	2022	Glutathione S-transferase (GSTT1) is involved in activation of detoxification reactions and catalysis of chemicals conjugation with glutathione.	Glutathione	132-143	glutathione S-transferase theta 1	Homo sapiens	27-32
33672092-6	2021	We summarize the association findings between drug hypersensitivity reactions and variants in the genes that encode the enzymes related to the redox system such as enzymes related to glutathione: Glutathione S-transferase (GSTM1, GSTP, GSTT1) and glutathione peroxidase (GPX1), thioredoxin reductase (TXNRD1 and TXNRD2), superoxide dismutase (SOD1, SOD2, and SOD3), catalase (CAT), aldo-keto reductase (AKR), and the peroxiredoxin system (PRDX1, PRDX2, PRDX3, PRDX4, PRDX5, PRDX6).	Glutathione	183-194	glutathione S-transferase theta 1	Homo sapiens	236-241
33546147-0	2021	Associations of Metabolic Genes (GSTT1, GSTP1, GSTM1) and Blood Mercury Concentrations Differ in Jamaican Children with and without Autism Spectrum Disorder.	Mercury	64-71	glutathione S-transferase theta 1	Homo sapiens	33-38
33544514-9	2021	CONCLUSIONS: Our findings suggest that GSTT1 null genotype may be associated with a decreased risk for pleural plaques and asbestosis, may modify the association between asbestos exposure and MM and may consequently act protectively on MM risk.	Asbestos	123-131	glutathione S-transferase theta 1	Homo sapiens	39-44
33381973-0	2021	Effects of GSTT1 Genotype on the Detoxification of 1,3-Butadiene Derived Diepoxide and Formation of Promutagenic DNA-DNA Cross-Links in Human Hapmap Cell Lines.	1,3-butadiene	51-64	glutathione S-transferase theta 1	Homo sapiens	11-16
33381973-0	2021	Effects of GSTT1 Genotype on the Detoxification of 1,3-Butadiene Derived Diepoxide and Formation of Promutagenic DNA-DNA Cross-Links in Human Hapmap Cell Lines.	diepoxide	73-82	glutathione S-transferase theta 1	Homo sapiens	11-16
33381973-6	2021	Glutathione-S-transferase theta 1 (GSTT1) facilitates the conjugation of DEB to glutathione as the first step of its detoxification and subsequent elimination via the mercapturic acid pathway.	Glutathione	80-91	glutathione S-transferase theta 1	Homo sapiens	0-33
33381973-6	2021	Glutathione-S-transferase theta 1 (GSTT1) facilitates the conjugation of DEB to glutathione as the first step of its detoxification and subsequent elimination via the mercapturic acid pathway.	Glutathione	80-91	glutathione S-transferase theta 1	Homo sapiens	35-40
33381973-6	2021	Glutathione-S-transferase theta 1 (GSTT1) facilitates the conjugation of DEB to glutathione as the first step of its detoxification and subsequent elimination via the mercapturic acid pathway.	Acetylcysteine	167-183	glutathione S-transferase theta 1	Homo sapiens	0-33
33381973-6	2021	Glutathione-S-transferase theta 1 (GSTT1) facilitates the conjugation of DEB to glutathione as the first step of its detoxification and subsequent elimination via the mercapturic acid pathway.	Acetylcysteine	167-183	glutathione S-transferase theta 1	Homo sapiens	35-40
33381973-7	2021	Human biomonitoring studies have revealed a strong association between GSTT1 copy number and urinary concentrations of BD-mercapturic acids, suggesting that it plays an important role in the metabolism of BD.	bd-mercapturic acids	119-139	glutathione S-transferase theta 1	Homo sapiens	71-76
33381973-11	2021	Consistent with the protective effect of GSH conjugation against DEB-derived apoptosis, GSTT1 positive cell lines formed significantly more DEB-GSH conjugate than GSTT1 negative cell lines.	Glutathione	41-44	glutathione S-transferase theta 1	Homo sapiens	88-93
33381973-11	2021	Consistent with the protective effect of GSH conjugation against DEB-derived apoptosis, GSTT1 positive cell lines formed significantly more DEB-GSH conjugate than GSTT1 negative cell lines.	Glutathione	41-44	glutathione S-transferase theta 1	Homo sapiens	163-168
33381973-11	2021	Consistent with the protective effect of GSH conjugation against DEB-derived apoptosis, GSTT1 positive cell lines formed significantly more DEB-GSH conjugate than GSTT1 negative cell lines.	Glutathione	144-147	glutathione S-transferase theta 1	Homo sapiens	88-93
32719018-10	2020	CONCLUSIONS: The polymorphism in GSTM1 and GSTT1 gene significantly damage DNA in personnel occupationally exposed to VA.	Vanillic Acid	118-120	glutathione S-transferase theta 1	Homo sapiens	43-48
32734539-1	2020	The objective of this study was to identify and evaluate the impact of exposure to mixtures of organochloride pesticides (OCPs) in agricultural workers by detecting their effects on the activity of the enzyme glutathione S-transferase (GST) and the presence of polymorphisms of the GSTT1 and GSTM1 genes.	organochloride	95-109	glutathione S-transferase theta 1	Homo sapiens	282-287
33452993-0	2021	Effects of GSTT1 and GSTM1 polymorphisms in glutathione levels and breast cancer development in Brazilian patients.	Glutathione	44-55	glutathione S-transferase theta 1	Homo sapiens	11-16
33452993-6	2021	The mean concentration values in nmol/L of GSH were 20.37 +- 5.82 for patients with null genotypes for both genes, 19.75 +- 3.47 for null GSTT1, 17.22 +- 1.35 for active GSTT1, 18.82 +- 1.96 for absent GSTM1, and 16.59 +- 1.66 for active GSTM1, but no significance was found.	Glutathione	43-46	glutathione S-transferase theta 1	Homo sapiens	170-175
33834724-6	2021	RESULTS: In the insomnia group, carriers of the normal GSTT1 genotype had higher diene conjugates with lower glutathione peroxidase activity as compared to controls.	diene	81-86	glutathione S-transferase theta 1	Homo sapiens	55-60
33834724-6	2021	RESULTS: In the insomnia group, carriers of the normal GSTT1 genotype had higher diene conjugates with lower glutathione peroxidase activity as compared to controls.	Glutathione	109-120	glutathione S-transferase theta 1	Homo sapiens	55-60
33834724-7	2021	When comparing groups of women with the deletion in GSTT1, an increase in the content of substrates and lipid peroxidation products was observed at all stages of lipid peroxidation, oxidized glutathione, glutathione S-transferase activity with a decrease in the content of reduced glutathione and retinol in the insomnia group as compared to controls.	Glutathione	191-202	glutathione S-transferase theta 1	Homo sapiens	52-57
33834724-7	2021	When comparing groups of women with the deletion in GSTT1, an increase in the content of substrates and lipid peroxidation products was observed at all stages of lipid peroxidation, oxidized glutathione, glutathione S-transferase activity with a decrease in the content of reduced glutathione and retinol in the insomnia group as compared to controls.	Glutathione	204-215	glutathione S-transferase theta 1	Homo sapiens	52-57
33834724-7	2021	When comparing groups of women with the deletion in GSTT1, an increase in the content of substrates and lipid peroxidation products was observed at all stages of lipid peroxidation, oxidized glutathione, glutathione S-transferase activity with a decrease in the content of reduced glutathione and retinol in the insomnia group as compared to controls.	Vitamin A	297-304	glutathione S-transferase theta 1	Homo sapiens	52-57
32289338-8	2020	However, in children with GSTM1 null and GSTT1 present, increasing acetaminophen use for non-respiratory reasons was associated with reduced FEV1 and MEF at 18 years (interaction between GSTM1/T1 and acetaminophen p<0 05).	Acetaminophen	67-80	glutathione S-transferase theta 1	Homo sapiens	41-46
32661462-7	2020	We used conditional logistic regression (CLR) models to assess associations of PCBs and OC pesticides with ASD, individually or interactively with GST genes (GSTT1, GSTM1, GSTP1).	Polychlorinated Biphenyls	79-83	glutathione S-transferase theta 1	Homo sapiens	158-163
32022258-11	2020	For example, higher dietary iron was most strongly associated with increased breast cancer risk among women with GSTT1 deletion or GSTM1/GSTT1 double deletions (pinteraction  < 0.05).	Iron	28-32	glutathione S-transferase theta 1	Homo sapiens	113-118
32022258-11	2020	For example, higher dietary iron was most strongly associated with increased breast cancer risk among women with GSTT1 deletion or GSTM1/GSTT1 double deletions (pinteraction  < 0.05).	Iron	28-32	glutathione S-transferase theta 1	Homo sapiens	137-142
33295410-1	2020	BACKGROUND: This study aimed to investigate the deletion polymorphisms of the genes of the glutathione S-transferase family GSTT1 and GSTM1 in patients with Polycystic Ovarian Syndrome (PCOS), comparing them with a control population.	Glutathione	91-102	glutathione S-transferase theta 1	Homo sapiens	124-129
32525579-9	2020	Also, the GSTT1 null genotype was associated with increased TBARS in oligozoospermia and asthenozoospermia.	Thiobarbituric Acid Reactive Substances	60-65	glutathione S-transferase theta 1	Homo sapiens	10-15
32488710-3	2020	Genetic polymorphisms in genes encoding PAH-metabolizing enzymes like glutathione S-transferases (GSTM1, GSTP1, GSTT1) which conjugate glutathione to PAHs for reduction of oxidative stress may affect an individual"s response to PAH exposure.	Polycyclic Aromatic Hydrocarbons	40-43	glutathione S-transferase theta 1	Homo sapiens	112-117
32488710-3	2020	Genetic polymorphisms in genes encoding PAH-metabolizing enzymes like glutathione S-transferases (GSTM1, GSTP1, GSTT1) which conjugate glutathione to PAHs for reduction of oxidative stress may affect an individual"s response to PAH exposure.	Glutathione	70-81	glutathione S-transferase theta 1	Homo sapiens	112-117
32488710-3	2020	Genetic polymorphisms in genes encoding PAH-metabolizing enzymes like glutathione S-transferases (GSTM1, GSTP1, GSTT1) which conjugate glutathione to PAHs for reduction of oxidative stress may affect an individual"s response to PAH exposure.	Glutathione	135-146	glutathione S-transferase theta 1	Homo sapiens	112-117
32488710-3	2020	Genetic polymorphisms in genes encoding PAH-metabolizing enzymes like glutathione S-transferases (GSTM1, GSTP1, GSTT1) which conjugate glutathione to PAHs for reduction of oxidative stress may affect an individual"s response to PAH exposure.	Polycyclic Aromatic Hydrocarbons	150-153	glutathione S-transferase theta 1	Homo sapiens	112-117
32488710-10	2020	The null state of GSTT1 was significantly associated with high concentrations of 1-OHP in urea (p < 0.01).	Oxaliplatin	81-86	glutathione S-transferase theta 1	Homo sapiens	18-23
32488710-10	2020	The null state of GSTT1 was significantly associated with high concentrations of 1-OHP in urea (p < 0.01).	Urea	90-94	glutathione S-transferase theta 1	Homo sapiens	18-23
32237725-6	2020	BD is metabolically activated to 3,4-epoxy-1-butene (EB), which can be detoxified by glutathione S-transferase theta 1 (GSTT1)-mediated conjugation with glutathione, or can react with DNA to form N7-(1-hydroxy-3-buten-2-yl)guanine (EB-GII) adducts.	3,4-epoxy-1-butene	33-51	glutathione S-transferase theta 1	Homo sapiens	85-118
32751086-5	2020	Moreover, serum vitamin C level also is dependent on genetic factors, such as SLC23A1 and SLC23A2 genes, encoding sodium-dependent vitamin C transporters and GSTM1, GSTP1 and GSTT1 genes which encode glutathione S-transferases.	Ascorbic Acid	16-25	glutathione S-transferase theta 1	Homo sapiens	175-180
32237725-6	2020	BD is metabolically activated to 3,4-epoxy-1-butene (EB), which can be detoxified by glutathione S-transferase theta 1 (GSTT1)-mediated conjugation with glutathione, or can react with DNA to form N7-(1-hydroxy-3-buten-2-yl)guanine (EB-GII) adducts.	3,4-epoxy-1-butene	33-51	glutathione S-transferase theta 1	Homo sapiens	120-125
32237725-6	2020	BD is metabolically activated to 3,4-epoxy-1-butene (EB), which can be detoxified by glutathione S-transferase theta 1 (GSTT1)-mediated conjugation with glutathione, or can react with DNA to form N7-(1-hydroxy-3-buten-2-yl)guanine (EB-GII) adducts.	3,4-epoxy-1-butene	53-55	glutathione S-transferase theta 1	Homo sapiens	85-118
32237725-6	2020	BD is metabolically activated to 3,4-epoxy-1-butene (EB), which can be detoxified by glutathione S-transferase theta 1 (GSTT1)-mediated conjugation with glutathione, or can react with DNA to form N7-(1-hydroxy-3-buten-2-yl)guanine (EB-GII) adducts.	3,4-epoxy-1-butene	53-55	glutathione S-transferase theta 1	Homo sapiens	120-125
32237725-6	2020	BD is metabolically activated to 3,4-epoxy-1-butene (EB), which can be detoxified by glutathione S-transferase theta 1 (GSTT1)-mediated conjugation with glutathione, or can react with DNA to form N7-(1-hydroxy-3-buten-2-yl)guanine (EB-GII) adducts.	Glutathione	85-96	glutathione S-transferase theta 1	Homo sapiens	120-125
32237725-6	2020	BD is metabolically activated to 3,4-epoxy-1-butene (EB), which can be detoxified by glutathione S-transferase theta 1 (GSTT1)-mediated conjugation with glutathione, or can react with DNA to form N7-(1-hydroxy-3-buten-2-yl)guanine (EB-GII) adducts.	N-7-(1-hydroxy-3-buten-2-yl)guanine	196-230	glutathione S-transferase theta 1	Homo sapiens	85-118
32237725-6	2020	BD is metabolically activated to 3,4-epoxy-1-butene (EB), which can be detoxified by glutathione S-transferase theta 1 (GSTT1)-mediated conjugation with glutathione, or can react with DNA to form N7-(1-hydroxy-3-buten-2-yl)guanine (EB-GII) adducts.	N-7-(1-hydroxy-3-buten-2-yl)guanine	196-230	glutathione S-transferase theta 1	Homo sapiens	120-125
32237725-6	2020	BD is metabolically activated to 3,4-epoxy-1-butene (EB), which can be detoxified by glutathione S-transferase theta 1 (GSTT1)-mediated conjugation with glutathione, or can react with DNA to form N7-(1-hydroxy-3-buten-2-yl)guanine (EB-GII) adducts.	eb-gii	232-238	glutathione S-transferase theta 1	Homo sapiens	85-118
32237725-6	2020	BD is metabolically activated to 3,4-epoxy-1-butene (EB), which can be detoxified by glutathione S-transferase theta 1 (GSTT1)-mediated conjugation with glutathione, or can react with DNA to form N7-(1-hydroxy-3-buten-2-yl)guanine (EB-GII) adducts.	eb-gii	232-238	glutathione S-transferase theta 1	Homo sapiens	120-125
32237725-8	2020	We found that GSTT1- HapMap cells treated with EB in culture produced lower levels of glutathione conjugates and were more susceptible to apoptosis, but had similar numbers of EB-GII adducts.	Glutathione	86-97	glutathione S-transferase theta 1	Homo sapiens	14-19
32237725-9	2020	Our results suggest that GSTT1 can influence an individual"s susceptibility to butadiene-derived epoxides.	butadiene-derived epoxides	79-105	glutathione S-transferase theta 1	Homo sapiens	25-30
32188413-8	2020	Analysis by gender, BMI and alcohol showed that association of GSTT1-null with risk of essential hypertension seems to be significant when BMI < 30 Kg/m2, in non-smokers and in alcohol users (all OR >= 1.77; p <= 0.008).	Alcohols	28-35	glutathione S-transferase theta 1	Homo sapiens	63-68
32435918-0	2020	GSTM1 null and GSTT1 null: predictors of cisplatin-caused acute ototoxicity measured by DPOAEs.	Cisplatin	41-50	glutathione S-transferase theta 1	Homo sapiens	15-20
32543462-11	2020	Only GSTT1 polymorphism recorded a significant change in percent methylation of Alu elements among urban and rural groups.	METHYL HYDROGEN (S)-ACETYLPHOSPHONATE	80-83	glutathione S-transferase theta 1	Homo sapiens	5-10
32188413-8	2020	Analysis by gender, BMI and alcohol showed that association of GSTT1-null with risk of essential hypertension seems to be significant when BMI < 30 Kg/m2, in non-smokers and in alcohol users (all OR >= 1.77; p <= 0.008).	Alcohols	177-184	glutathione S-transferase theta 1	Homo sapiens	63-68
32188413-10	2020	CONCLUSION: Our results confirm that GSTT1-null genotype is significantly associated with risk of developing essential hypertension in Burkinabe, especially when BMI < 30 Kg/m2, in non-smokers and in alcohol users, and it showed that the double deletion GSTM1-null/GSTT1-null genotypes may influence body lipids repartition.	Alcohols	200-207	glutathione S-transferase theta 1	Homo sapiens	37-42
32342808-8	2020	Subsequently, the levels of, glycolic acid, erythronic acid, lactic acid, citric acid, fructose, stearic acid, 2-amino-2-methyl-1,3-propanediol and three unknown metabolites increased in GSTT1 positive patients; and the levels of proline, valine and two unknown metabolites decreased in GSTT1 positive patients.	2-amino-2-methyl-1,3-propandiol	111-143	glutathione S-transferase theta 1	Homo sapiens	187-192
31916636-1	2020	The enzyme glutathione S-transferase theta 1 (GSTT1) is involved in detoxifying chemicals, including reactive oxygen species (ROS).	Reactive Oxygen Species	101-124	glutathione S-transferase theta 1	Homo sapiens	11-44
31916636-1	2020	The enzyme glutathione S-transferase theta 1 (GSTT1) is involved in detoxifying chemicals, including reactive oxygen species (ROS).	Reactive Oxygen Species	101-124	glutathione S-transferase theta 1	Homo sapiens	46-51
31916636-1	2020	The enzyme glutathione S-transferase theta 1 (GSTT1) is involved in detoxifying chemicals, including reactive oxygen species (ROS).	Reactive Oxygen Species	126-129	glutathione S-transferase theta 1	Homo sapiens	11-44
31916636-1	2020	The enzyme glutathione S-transferase theta 1 (GSTT1) is involved in detoxifying chemicals, including reactive oxygen species (ROS).	Reactive Oxygen Species	126-129	glutathione S-transferase theta 1	Homo sapiens	46-51
31771940-9	2020	Much stronger effect was observed among subjects with the null genotype of both GSTM1 and GSTT1: in these individuals, PEITC increased urinary levels of MHBMA by 58.68% (p = 0.004) and 89.97% (p = 0.001), respectively, but did not have a significant effect on urinary DHBMA.	phenethyl isothiocyanate	119-124	glutathione S-transferase theta 1	Homo sapiens	90-95
31771940-9	2020	Much stronger effect was observed among subjects with the null genotype of both GSTM1 and GSTT1: in these individuals, PEITC increased urinary levels of MHBMA by 58.68% (p = 0.004) and 89.97% (p = 0.001), respectively, but did not have a significant effect on urinary DHBMA.	1-hydroxybutene-2-yl mercapturic acid	153-158	glutathione S-transferase theta 1	Homo sapiens	90-95
31771940-9	2020	Much stronger effect was observed among subjects with the null genotype of both GSTM1 and GSTT1: in these individuals, PEITC increased urinary levels of MHBMA by 58.68% (p = 0.004) and 89.97% (p = 0.001), respectively, but did not have a significant effect on urinary DHBMA.	dhbma	268-273	glutathione S-transferase theta 1	Homo sapiens	90-95
31771940-10	2020	These results reveal a potentially protective effect of PEITC treatment with respect to the detoxification of 1,3-butadiene in cigarette smokers, specifically in those null for GSTT1, and provide further evidence in support of stronger chemopreventive effects from consumption of dietary isothiocyanates in these individuals.	phenethyl isothiocyanate	56-61	glutathione S-transferase theta 1	Homo sapiens	177-182
31218944-0	2019	Polymorphisms in GSTM1 and GSTT1 influence the response and treatment outcome in lung cancer patients treated with platinum-based chemotherapy.	Platinum	115-123	glutathione S-transferase theta 1	Homo sapiens	27-32
31681592-14	2019	The in vitro study revealed significantly higher number of apoptotic cells at 12 nM of bortezomib in GSTT1-present, GSTM1-null/present, -308GG and -238GG/GA+AA genotypes.	bortezomib	87-97	glutathione S-transferase theta 1	Homo sapiens	101-106
30803216-6	2019	Moreover, risk was decreased in alcohol users carrying the GSTT1null (OR=0.39; 95% CI=0.16-0.97) genotype.	Alcohols	32-39	glutathione S-transferase theta 1	Homo sapiens	59-64
31249357-2	2019	Glutathione S-transferases (GSTs) participate in CDDP excretion from cells, and genes encoding GSTs, GSTM1, GSTT1and GSTP1, are polymorphic in humans.	Cisplatin	49-53	glutathione S-transferase theta 1	Homo sapiens	108-113
31249357-7	2019	Patients with GSTT1 genes showed 7.23- and 5.37-fold higher likelihood of presenting vomiting and ototoxicity, lower glomerular filtration rate (GFR), and lower elimination of CDDP in urine relative to patients with deleted genes.	Cisplatin	176-180	glutathione S-transferase theta 1	Homo sapiens	14-19
31249357-10	2019	Our findings provide preliminary evidence that inherited abnormalities in CDDP metabolism, related to GSTT1 and GSTP1 Ile105Val polymorphisms, alter outcomes of HNSCC patients treated with CDDP and RT.	Cisplatin	74-78	glutathione S-transferase theta 1	Homo sapiens	102-107
28403014-8	2018	This meta-analysis indicates a possible association between the variant genotypes of GSTM1, GSTT1, NAT2 and SULT1A1, occupational exposure to aromatic amines or PAHs, and development of BC.	aromatic amines	142-157	glutathione S-transferase theta 1	Homo sapiens	92-97
30650146-14	2019	After grouping PFOA levels into three groups: undetected, below and above the median in those with detected, children in above the median group who had the GSTT1-null, or GSTM1-null genotype exhibited a higher odds ratio for AD (OR [95%CI] = 3.45 [1.26-9.99] and 2.92 [1.12-7.91], respectively) as compared to the undetected group.	perfluorooctanoic acid	15-19	glutathione S-transferase theta 1	Homo sapiens	156-161
30650146-15	2019	CONCLUSIONS: Our data demonstrated that in-utero PFOA exposure with GSTT1/M1 null genotype were associated with AD.	perfluorooctanoic acid	49-53	glutathione S-transferase theta 1	Homo sapiens	68-73
30341887-6	2018	RESULTS Twenty-three published studies were identified that showed that both the null GSTM1 and the GG genotype of GSTP1 IIe105Val were associated with improved treatment response to cisplatin-based chemotherapy (GSTT1 present/null: OR=1.328; 95% CI, 1.074-1.643) (GSTP1 GG + AG vs. AA: OR=0.596; 95% CI, 0.468-0.759).	Cisplatin	183-192	glutathione S-transferase theta 1	Homo sapiens	213-218
30471640-1	2019	Genetic variations in the glutathione S-transferase genes GSTT1 and GSTM1 have been widely studied, and homozygous deletions or null genotypes have been reported in different populations.	Glutathione	26-37	glutathione S-transferase theta 1	Homo sapiens	58-63
28403014-8	2018	This meta-analysis indicates a possible association between the variant genotypes of GSTM1, GSTT1, NAT2 and SULT1A1, occupational exposure to aromatic amines or PAHs, and development of BC.	Polycyclic Aromatic Hydrocarbons	161-165	glutathione S-transferase theta 1	Homo sapiens	92-97
29145054-10	2018	For combined analysis with GSTM1 and GSTT1, GSTM1 null and GSTT1 present group showed a significant inverse association of BPb with birthweight and head circumference in males.	bpb	123-126	glutathione S-transferase theta 1	Homo sapiens	37-42
29845565-0	2018	Associations between sperm quality, DNA damage, and CYP1A1, GSTT1 and GSTM1 polymorphisms with 1-hydroxypyrene urinary levels in men occupationally exposed to polycyclic aromatic hydrocarbons.	1-hydroxypyrene	95-110	glutathione S-transferase theta 1	Homo sapiens	60-65
29845565-0	2018	Associations between sperm quality, DNA damage, and CYP1A1, GSTT1 and GSTM1 polymorphisms with 1-hydroxypyrene urinary levels in men occupationally exposed to polycyclic aromatic hydrocarbons.	Polycyclic Aromatic Hydrocarbons	159-191	glutathione S-transferase theta 1	Homo sapiens	60-65
30112115-13	2018	To conclude, deletion of GSTT1, rs1695 and rs1799793 may constitute potential predictors of platinum-induced ototoxicity.	Platinum	92-100	glutathione S-transferase theta 1	Homo sapiens	25-30
29875071-9	2018	Recent molecular epidemiology has indicated that activation of brominated trihalomethanes by the enzyme GSTT1 and the lack of metabolism of haloacetic acids by a variant of enzyme GSTZ1 are likely causative mechanisms for bladder cancer associated with exposure to chlorinated water.	Trihalomethanes	74-89	glutathione S-transferase theta 1	Homo sapiens	104-109
29204680-0	2018	Association between polymorphism of GSTP1, GSTT1, GSTM1 and CYP2E1 genes and susceptibility to benzene-induced hematotoxicity.	Benzene	95-102	glutathione S-transferase theta 1	Homo sapiens	43-48
29204680-3	2018	The main objective of this study was to ascertain whether polymorphism of GSTP1, GSTM1, GSTT1 and CYP2E1 genes might influence susceptibility to the adverse effects of benzene among employees of a petrochemical plant.	Benzene	168-175	glutathione S-transferase theta 1	Homo sapiens	88-93
29204680-12	2018	The results of this study showed that, individuals carrying null GSTT1 or both null STT1 and GSTM1 genotypes had a higher risk and were more susceptible to benzene-induced hematological disorders.	Benzene	156-163	glutathione S-transferase theta 1	Homo sapiens	65-70
29145054-10	2018	For combined analysis with GSTM1 and GSTT1, GSTM1 null and GSTT1 present group showed a significant inverse association of BPb with birthweight and head circumference in males.	bpb	123-126	glutathione S-transferase theta 1	Homo sapiens	59-64
29582627-1	2018	Alcohol detoxification is governed by ADH1B,ALDH2, GSTM1 and GSTT1 genes that encode functional enzymes which are coordinated with each other to removehighly toxic metabolites i.e. acetaldehyde as well as reactive oxygen species generated through detoxification processes.Some communities in the population appears to be at greater risk for development of the liver cancer due to geneticpredispositions.	Alcohols	0-7	glutathione S-transferase theta 1	Homo sapiens	61-66
29582627-1	2018	Alcohol detoxification is governed by ADH1B,ALDH2, GSTM1 and GSTT1 genes that encode functional enzymes which are coordinated with each other to removehighly toxic metabolites i.e. acetaldehyde as well as reactive oxygen species generated through detoxification processes.Some communities in the population appears to be at greater risk for development of the liver cancer due to geneticpredispositions.	Acetaldehyde	181-193	glutathione S-transferase theta 1	Homo sapiens	61-66
29582627-1	2018	Alcohol detoxification is governed by ADH1B,ALDH2, GSTM1 and GSTT1 genes that encode functional enzymes which are coordinated with each other to removehighly toxic metabolites i.e. acetaldehyde as well as reactive oxygen species generated through detoxification processes.Some communities in the population appears to be at greater risk for development of the liver cancer due to geneticpredispositions.	Reactive Oxygen Species	205-228	glutathione S-transferase theta 1	Homo sapiens	61-66
29523098-1	2018	BACKGROUND: The aim of this study was to evaluate whether the glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) null alleles may contribute to carbamazepine-induced hepatotoxicity.	Carbamazepine	145-158	glutathione S-transferase theta 1	Homo sapiens	107-112
29523098-2	2018	METHODS: A cross-sectional prospective study was conducted to identify the frequency distribution of GSTM1 and GSTT1 alleles in 129 Tunisian epileptic patients treated with carbamazepine.	Carbamazepine	173-186	glutathione S-transferase theta 1	Homo sapiens	111-116
30701758-4	2018	The analysis of the frequency distribution of deletion polymorphisms of GSTM1 and GSTT1 glutathione among the workers of the basic trades involving patients with cardiovascular disease (CVD) and practically healthy workers.	Glutathione	88-99	glutathione S-transferase theta 1	Homo sapiens	82-87
30454686-4	2018	In contrast, glutathione-S-transferase (GST) M1 and GSTT1 are primary responsible for detoxification of the AFB1 by catalyzing the conjugation of GSH to AFBO in humans, whereas GSTM2 in a nonhuman primate, GSTA3 in mice, GSTA5 in rats, and GSTA1, GSTA2, GSTA3 and GSTA4 in the turkey are important.	Glutathione	146-149	glutathione S-transferase theta 1	Homo sapiens	52-57
28898950-8	2018	When maternal urinary BPA concentration in the third trimester increased by 1 log-transformed unit of BPA/Cr, the third trimester femur length decreased 0.03(0.01)cm in the whole and 0.06(0.02)cm in the GSTM1/GSTT1 either null group.	bisphenol A	22-25	glutathione S-transferase theta 1	Homo sapiens	209-214
29619129-6	2018	Independent associations were found between the variant A allele and lower total cholesterol, between c2 allele and low alpha-1 antitrypsin and between the null GSTT1 variant and high indirect and total bilirubin in SCA-HU+ patients.	Bilirubin	203-212	glutathione S-transferase theta 1	Homo sapiens	161-166
27168101-4	2017	In patients developing neutropenia, ABCB1 3435TT and homozygosity for GSTT1null (glutathione-S-transferase; conjugates reactive clozapine metabolites into glutathione) were more frequent compared with control (34% versus 20%, P=0.05 and 31% versus 14%, P=0.03), whereas GSTM1null was less frequent in these patients (31% versus 52%, P=0.03).	Clozapine	128-137	glutathione S-transferase theta 1	Homo sapiens	70-75
29074540-6	2017	Higher NO2 exposure was associated with lower forced vital capacity for carriers of the GSTT1 null genotype.TRAP exposures were associated with increased risk of asthma, wheeze and lower lung function in middle-aged adults.	Nitrogen Dioxide	7-10	glutathione S-transferase theta 1	Homo sapiens	88-93
28386678-7	2017	GSTM1 and LEPR variants exhibited risk modulation for non-muscle-invasive bladder cancer (NMIBC); GSTT1 and PPARG variants for muscle-invasive bladder cancer (MIBC), and ACE variant for NMIBC as well as MIBC.	4-METHYL-2-PENTANOL	159-163	glutathione S-transferase theta 1	Homo sapiens	98-103
28976264-1	2017	AIM: To investigate the impact of genetic variants in CYP2C9, CYP2C19, CYP3A4, GSTT1, GSTM1 and GSTP1 on the efficacy of cyclophosphamide (CYC) therapy in patients with lupus nephritis.	Cyclophosphamide	121-137	glutathione S-transferase theta 1	Homo sapiens	79-84
28976264-1	2017	AIM: To investigate the impact of genetic variants in CYP2C9, CYP2C19, CYP3A4, GSTT1, GSTM1 and GSTP1 on the efficacy of cyclophosphamide (CYC) therapy in patients with lupus nephritis.	Cyclophosphamide	139-142	glutathione S-transferase theta 1	Homo sapiens	79-84
27168101-4	2017	In patients developing neutropenia, ABCB1 3435TT and homozygosity for GSTT1null (glutathione-S-transferase; conjugates reactive clozapine metabolites into glutathione) were more frequent compared with control (34% versus 20%, P=0.05 and 31% versus 14%, P=0.03), whereas GSTM1null was less frequent in these patients (31% versus 52%, P=0.03).	Glutathione	81-92	glutathione S-transferase theta 1	Homo sapiens	70-75
28572675-6	2017	Our meta-analysis suggested that the GSTP1 IIe105Val, GSTM1 and GSTT1 null variants might be predictive factors for the efficacy of platinum-based chemotherapy to NSCLC patients.	Platinum	132-140	glutathione S-transferase theta 1	Homo sapiens	64-69
28692121-13	2017	According to the analysis of the variable alcohol consumption, we found that in the case group the presence of the GSTT1 gene was higher in individuals who reported not drinking alcohol.	Alcohols	42-49	glutathione S-transferase theta 1	Homo sapiens	115-120
28692121-13	2017	According to the analysis of the variable alcohol consumption, we found that in the case group the presence of the GSTT1 gene was higher in individuals who reported not drinking alcohol.	Alcohols	178-185	glutathione S-transferase theta 1	Homo sapiens	115-120
28744640-3	2017	A decrease in glutathione S-transferase activity was found in blood and ejaculate specimens from fertile and infertile carriers of nonfunctional GSTT1(0/0)/GSTM1(0/0) genotypes.	Glutathione	14-25	glutathione S-transferase theta 1	Homo sapiens	145-150
28744640-4	2017	In infertile carriers of nonfunctional GSTT1(0/0)/GSTM1(0/0) genotypes determining reduced glutathione S-transferase activity, a decrease in the concentration of low-molecular-weight cell antioxidant (reduced glutathione) and an increase in the concentration of secondary LPO products (TBA-reactive substances) were revealed.	Glutathione	91-102	glutathione S-transferase theta 1	Homo sapiens	39-44
28584578-8	2017	Plasma levels of alpha-tocopherol increased significantly in GSTT1 wild genotype (P &lt; 0.05); however, plasma level of beta-carotene increased significantly in GSTT1 null genotype (P &lt; 0.01).	alpha-Tocopherol	17-33	glutathione S-transferase theta 1	Homo sapiens	61-66
28584578-8	2017	Plasma levels of alpha-tocopherol increased significantly in GSTT1 wild genotype (P &lt; 0.05); however, plasma level of beta-carotene increased significantly in GSTT1 null genotype (P &lt; 0.01).	beta Carotene	121-134	glutathione S-transferase theta 1	Homo sapiens	162-167
28521016-2	2017	Dihaloalkanes are metabolically activated by GSH S-transferase theta1 (GSTT1) to yield products such as episulfonium ions.	dihaloalkanes	0-13	glutathione S-transferase theta 1	Homo sapiens	45-69
28521016-2	2017	Dihaloalkanes are metabolically activated by GSH S-transferase theta1 (GSTT1) to yield products such as episulfonium ions.	dihaloalkanes	0-13	glutathione S-transferase theta 1	Homo sapiens	71-76
28521016-3	2017	However, whether the GSTT1-mediated step of these dihaloalkanes is related to occupational cholangiocarcinoma is not known.	dihaloalkanes	50-63	glutathione S-transferase theta 1	Homo sapiens	21-26
28445029-5	2017	Surprisingly, we also show that fragment-based NHS-ester ligands can be made to confer selectivity for specific lysine hotspots on specific targets including Dpyd, Aldh2, and Gstt1.	phloretic acid	47-56	glutathione S-transferase theta 1	Homo sapiens	175-180
28445029-5	2017	Surprisingly, we also show that fragment-based NHS-ester ligands can be made to confer selectivity for specific lysine hotspots on specific targets including Dpyd, Aldh2, and Gstt1.	Lysine	112-118	glutathione S-transferase theta 1	Homo sapiens	175-180
28426525-6	2017	CONCLUSIONS: GSTT1 and GSTM1 may modulate DNA damage levels of p53 gene when exposed to polycyclic aromatic hydrocarbons.	Polycyclic Aromatic Hydrocarbons	88-120	glutathione S-transferase theta 1	Homo sapiens	13-18
28431992-7	2017	Whole genome array CGH technique can be used to identify potential genes, biofunctions and chromosomal abnormalities associated with RSA which is supported by our findings of a number of novel CNVs/genes (22q11.23/GSTT1, 3p22.2/CTDSPL, 6p21.32/HLA, 8p22/MSR1, and 14q32.33/AKT1) and pathways in patients affected with RSA.	rabbit sperm membrane autoantigen	133-136	glutathione S-transferase theta 1	Homo sapiens	214-219
28572675-7	2017	The use of GSTP1 IIe105Val, GSTM1 and GSTT1 null polymorphisms as predictive factors of efficacy of personalized platinum-based chemotherapy to NSCLC patients requires further verification with multi-center, multi-ethnic and large-sample-size pharmacogenetic studies.	Platinum	113-121	glutathione S-transferase theta 1	Homo sapiens	38-43
28365671-1	2017	The aim of this cross-sectional study was to see whether genetic polymorphisms of the enzymes CYP1A1, GSTM1, and GSTT1 are associated with higher risk of coronary artery disease (CAD) and whether they affect lipid profile in 252 subjects living near a natural gas plant, who are likely to be exposed to polycyclic aromatic hydrocarbons (PAHs).	Polycyclic Aromatic Hydrocarbons	303-335	glutathione S-transferase theta 1	Homo sapiens	113-118
28575886-11	2017	The recipients" GSTM1 polymorphism, alone and in combination with donors" GSTM1 and GSTT1, significantly affected the creatinine clearance on discharge day.	Creatinine	118-128	glutathione S-transferase theta 1	Homo sapiens	84-89
28365671-1	2017	The aim of this cross-sectional study was to see whether genetic polymorphisms of the enzymes CYP1A1, GSTM1, and GSTT1 are associated with higher risk of coronary artery disease (CAD) and whether they affect lipid profile in 252 subjects living near a natural gas plant, who are likely to be exposed to polycyclic aromatic hydrocarbons (PAHs).	Polycyclic Aromatic Hydrocarbons	337-341	glutathione S-transferase theta 1	Homo sapiens	113-118
28365671-6	2017	MANCOVA analysis, which included lipid parameters, glucose, and BMI with sex, age, hypertension and smoking status as covariates, showed a significant difference between the GSTT1*0 and GSTT1*1 allele carriers (p=0.001).	Glucose	51-58	glutathione S-transferase theta 1	Homo sapiens	174-179
28365671-6	2017	MANCOVA analysis, which included lipid parameters, glucose, and BMI with sex, age, hypertension and smoking status as covariates, showed a significant difference between the GSTT1*0 and GSTT1*1 allele carriers (p=0.001).	Glucose	51-58	glutathione S-transferase theta 1	Homo sapiens	186-191
28365671-7	2017	UNIANCOVA with same covariates showed that total cholesterol and triglyceride levels were significantly higher in GSTT1*1 allele carriers than in GSTT1*0 carriers (p&lt;0.001 and p=0.006, respectively).	Cholesterol	49-60	glutathione S-transferase theta 1	Homo sapiens	114-119
28365671-7	2017	UNIANCOVA with same covariates showed that total cholesterol and triglyceride levels were significantly higher in GSTT1*1 allele carriers than in GSTT1*0 carriers (p&lt;0.001 and p=0.006, respectively).	Cholesterol	49-60	glutathione S-transferase theta 1	Homo sapiens	146-151
28365671-7	2017	UNIANCOVA with same covariates showed that total cholesterol and triglyceride levels were significantly higher in GSTT1*1 allele carriers than in GSTT1*0 carriers (p&lt;0.001 and p=0.006, respectively).	Triglycerides	65-77	glutathione S-transferase theta 1	Homo sapiens	114-119
28043265-0	2016	[Effects of genetic polymorphisms of GSTT1 and GSTM1 on metabolism of Polycyclic aromatic hydrocarbon in coal tar pitch workers].	Polycyclic Aromatic Hydrocarbons	70-101	glutathione S-transferase theta 1	Homo sapiens	37-42
28182092-8	2017	In conclusion, the GSTM1 and GSTT1 null genotypes increased the risk for premalignant and endoscopic gastric lesions, modulated by H. pylori, alcohol, or gastrotoxic drug consumption, while the presence of the GSTP1Val allele seemed to reduce the risk for premalignant lesions.	Alcohols	142-149	glutathione S-transferase theta 1	Homo sapiens	29-34
28555163-6	2017	Although GSTT1-mediated bioactivation of dihaloalkanes could be a plausible explanation for the production of reactive metabolites related to carcinogenesis based on previous studies, this catalytic pathway might not mainly contribute to 1,2-DCP-related occupational cholangiocarcinoma.	dihaloalkanes	41-54	glutathione S-transferase theta 1	Homo sapiens	9-14
26667829-9	2017	In case-only analysis, GSTT1-null genotype among alcohol users showed elevated risk of hepatotoxicity in HIV-infected individuals (P=0.12, OR=1.36, 95% confidence interval (CI): 0.94-1.97) as compared with GSTT1 genotypes.	Alcohols	49-56	glutathione S-transferase theta 1	Homo sapiens	23-28
26667829-9	2017	In case-only analysis, GSTT1-null genotype among alcohol users showed elevated risk of hepatotoxicity in HIV-infected individuals (P=0.12, OR=1.36, 95% confidence interval (CI): 0.94-1.97) as compared with GSTT1 genotypes.	Alcohols	49-56	glutathione S-transferase theta 1	Homo sapiens	206-211
28043265-1	2016	Objective: To investigate the influence of genetic polymorphisms of GSTT1 and GSTM1 on metabolism of polycyclic aromatic hydrocarbon (PAHs) in coal tar pitch workers and to explore the effective bio-marker of occupational exposure to coal tar pitch.	Polycyclic Aromatic Hydrocarbons	101-132	glutathione S-transferase theta 1	Homo sapiens	68-73
28043265-1	2016	Objective: To investigate the influence of genetic polymorphisms of GSTT1 and GSTM1 on metabolism of polycyclic aromatic hydrocarbon (PAHs) in coal tar pitch workers and to explore the effective bio-marker of occupational exposure to coal tar pitch.	Polycyclic Aromatic Hydrocarbons	134-138	glutathione S-transferase theta 1	Homo sapiens	68-73
28043265-9	2016	Conclusion: Carrying positive GSTT1 and GSTM1 promote polycyclic aromatic hydrocarbons in the body"s metabolism.	Polycyclic Aromatic Hydrocarbons	54-86	glutathione S-transferase theta 1	Homo sapiens	30-35
27713515-9	2016	However, there were nominally statistically significant interactions for SNPs in acrylamide-metabolizing enzymes: CYP2E1 (rs915906 and rs2480258) and the deletions of GSTM1 and GSTT1.	Acrylamide	81-91	glutathione S-transferase theta 1	Homo sapiens	177-182
27275760-9	2016	These GWAS results suggested a possible protective effect of lower GSTT1 copy number variants on the diol epoxide pathway, which was an unexpected result.	diol epoxide	101-113	glutathione S-transferase theta 1	Homo sapiens	67-72
27151508-8	2016	Moreover, plasma protein carbonyl level 4h after co-exposure was higher in the individuals who have the GSTT1 null genotype.	4h	40-42	glutathione S-transferase theta 1	Homo sapiens	104-109
27448814-11	2016	Our findings also suggested that GSTT1 and hOGG1 gene polymorphisms might play an important role in the individual risk of As-induced carotid atherosclerosis.	Arsenic	123-125	glutathione S-transferase theta 1	Homo sapiens	33-38
27084675-9	2016	The genotype distribution showed significant associations between GSTT1 and the As concentration (log10 iAs, P = 0.01) and metabolite patterns (log10 DMA, P = 0.05) in the urine.	Cacodylic Acid	150-153	glutathione S-transferase theta 1	Homo sapiens	66-71
27698905-1	2016	GSTT1 gene plays an important role in detoxification and clearance of reactive oxygen species(ROS).	Reactive Oxygen Species	70-93	glutathione S-transferase theta 1	Homo sapiens	0-5
27698905-1	2016	GSTT1 gene plays an important role in detoxification and clearance of reactive oxygen species(ROS).	Reactive Oxygen Species	94-97	glutathione S-transferase theta 1	Homo sapiens	0-5
26970590-6	2016	Subjects with GSTT1-present and GSTM1-null genotypes were susceptible to male infertility when exposed to 4-n-OP (OR=14.05, 95% CI=4.78-60.20, P=2.34x10(-5)).	4-octylphenol	106-112	glutathione S-transferase theta 1	Homo sapiens	14-19
26970898-0	2016	Interactions between CYP2E1, GSTZ1 and GSTT1 polymorphisms and exposure to drinking water trihalomethanes and their association with semen quality.	drinking water trihalomethanes	75-105	glutathione S-transferase theta 1	Homo sapiens	39-44
26970898-1	2016	Trihalomethanes (THMs) have been reported to be associated with altered semen quality, and this association may be modified by inherited differences in cytochrome P450 (CYP2E1) and glutathione S-transferase (GSTZ1 and GSTT1), which metabolize THMs.	Trihalomethanes	0-15	glutathione S-transferase theta 1	Homo sapiens	218-223
26970898-1	2016	Trihalomethanes (THMs) have been reported to be associated with altered semen quality, and this association may be modified by inherited differences in cytochrome P450 (CYP2E1) and glutathione S-transferase (GSTZ1 and GSTT1), which metabolize THMs.	Trihalomethanes	17-21	glutathione S-transferase theta 1	Homo sapiens	218-223
26970898-5	2016	GSTT1 genotype significantly modified the association between exposure to Br-THMs (sum of BDCM, DBCM and TBM) and below-reference sperm motility (Pint=0.02).	br-thms	74-81	glutathione S-transferase theta 1	Homo sapiens	0-5
26970898-6	2016	Men with above-median blood Br-THM levels had an increased odds ratio (OR) of below-reference sperm compared to men with below-median blood Br-THM levels (OR=2.15, 95% CI: 1.11, 4.19) in the GSTT1 null genotype only.	br-thm	28-34	glutathione S-transferase theta 1	Homo sapiens	191-196
26970898-8	2016	Our results suggest that GSTT1 polymorphisms modify Br-THM exposure relation with semen quality, and CYP2E1 polymorphisms are associated with internal levels of exposure to THMs.	br-thm	52-58	glutathione S-transferase theta 1	Homo sapiens	25-30
26729828-3	2016	Genetic evaluation determined that he had the GSTT1-null and GSTM1-null genotype, known to be an independent risk factor for developing oxaliplatin-induced SOS.	Oxaliplatin	136-147	glutathione S-transferase theta 1	Homo sapiens	46-51
27141907-6	2016	Cytochrome P450 (CYP450s) and glutathione S-transferases (GSTs) are the main metabolic enzymes of PAH and many other xenobiotics, and the polymorphisms of CYP1A1, CYP2E1, GSTM1, GSTT1 and GSTT2 may be associated with the risk of preterm birth.	Polycyclic Aromatic Hydrocarbons	98-101	glutathione S-transferase theta 1	Homo sapiens	178-183
26959369-0	2016	Benzene Uptake and Glutathione S-transferase T1 Status as Determinants of S-Phenylmercapturic Acid in Cigarette Smokers in the Multiethnic Cohort.	S-phenyl-N-acetylcysteine	74-98	glutathione S-transferase theta 1	Homo sapiens	19-47
25990411-11	2016	Individuals with GSTM1-/GSTT1- have a higher susceptibility to NAION (P &lt; 0.001); the GSTM1-/GSTT1+ genotype also had a significantly higher frequency in patients than in controls (P = 0.004).	naion	63-68	glutathione S-transferase theta 1	Homo sapiens	24-29
25990411-11	2016	Individuals with GSTM1-/GSTT1- have a higher susceptibility to NAION (P &lt; 0.001); the GSTM1-/GSTT1+ genotype also had a significantly higher frequency in patients than in controls (P = 0.004).	naion	63-68	glutathione S-transferase theta 1	Homo sapiens	96-101
27844021-5	2016	The aim of the present study was to investigate the association between GSTM1 and GSTT1 polymorphisms and risk of dependency to opium sap.	opium sap	128-137	glutathione S-transferase theta 1	Homo sapiens	82-87
26554337-4	2015	Therefore, we incubated GSTA1, GSTT1, GSTM1, and GSTP1 with glutathione and BO and quantified the formation of S-phenylglutathione.	Glutathione	60-71	glutathione S-transferase theta 1	Homo sapiens	31-36
26774148-9	2016	Our study has demonstrated an association of early onset of CDDP induced ototoxicity with the presence of two copies of GSTT1 gene (p=0,009) and with T allele of rs9332377 polymorphism in COMT gene (p=0,001).	Cisplatin	60-64	glutathione S-transferase theta 1	Homo sapiens	120-125
26554337-4	2015	Therefore, we incubated GSTA1, GSTT1, GSTM1, and GSTP1 with glutathione and BO and quantified the formation of S-phenylglutathione.	benzene oxide	76-78	glutathione S-transferase theta 1	Homo sapiens	31-36
26554337-8	2015	We conclude that GSTT1 is a critical enzyme in the detoxification of BO and that GSTP1 may also play an important role, while GSTA1 and GSTM1 seem to be less important.	benzene oxide	69-71	glutathione S-transferase theta 1	Homo sapiens	17-22
26318115-9	2015	The adverse genotype combination (unusual BCHE variants, PON1 55MM/-108TT and null genotype for both GSTM1 and GSTT1) potentially conferring a greater genetic risk from exposure to organophosphates was observed in 0.2% of our study population.	Organophosphates	181-197	glutathione S-transferase theta 1	Homo sapiens	111-116
26498776-11	2015	Additionally, Gsta3, Gstm2 and Gstt1 in Burn-CLP were significantly enriched in glutathione metabolism.	Glutathione	80-91	glutathione S-transferase theta 1	Homo sapiens	31-36
26877838-1	2015	The aim of this study was to investigate whether genetic polymorphisms of CYP2E1, GSTM1, and GSTT1 and lifestyle habits (smoking, drinking, and exercise) modulate the levels of urinary styrene metabolites such as mandelic acid (MA) and phenylglyoxylic acid (PGA) after occupational exposure to styrene.	Styrene	185-192	glutathione S-transferase theta 1	Homo sapiens	93-98
26877838-1	2015	The aim of this study was to investigate whether genetic polymorphisms of CYP2E1, GSTM1, and GSTT1 and lifestyle habits (smoking, drinking, and exercise) modulate the levels of urinary styrene metabolites such as mandelic acid (MA) and phenylglyoxylic acid (PGA) after occupational exposure to styrene.	mandelic acid	213-226	glutathione S-transferase theta 1	Homo sapiens	93-98
26877838-1	2015	The aim of this study was to investigate whether genetic polymorphisms of CYP2E1, GSTM1, and GSTT1 and lifestyle habits (smoking, drinking, and exercise) modulate the levels of urinary styrene metabolites such as mandelic acid (MA) and phenylglyoxylic acid (PGA) after occupational exposure to styrene.	phenylglyoxylic acid	236-256	glutathione S-transferase theta 1	Homo sapiens	93-98
26877838-1	2015	The aim of this study was to investigate whether genetic polymorphisms of CYP2E1, GSTM1, and GSTT1 and lifestyle habits (smoking, drinking, and exercise) modulate the levels of urinary styrene metabolites such as mandelic acid (MA) and phenylglyoxylic acid (PGA) after occupational exposure to styrene.	phenylglyoxylic acid	258-261	glutathione S-transferase theta 1	Homo sapiens	93-98
26877838-1	2015	The aim of this study was to investigate whether genetic polymorphisms of CYP2E1, GSTM1, and GSTT1 and lifestyle habits (smoking, drinking, and exercise) modulate the levels of urinary styrene metabolites such as mandelic acid (MA) and phenylglyoxylic acid (PGA) after occupational exposure to styrene.	Styrene	294-301	glutathione S-transferase theta 1	Homo sapiens	93-98
25876999-0	2015	Associations between the polymorphisms of GSTT1, GSTM1 and methylation of arsenic in the residents exposed to low-level arsenic in drinking water in China.	Arsenic	74-81	glutathione S-transferase theta 1	Homo sapiens	42-47
26175060-2	2015	In the present study, we confirmed associations between schizophrenia and the common CNVs in the glutathione (GSH)-related genes GSTT1, DDTL, and GSTM1 using quantitative real-time polymerase chain reaction analyses of 620 patients with schizophrenia and in 622 controls.	Glutathione	97-108	glutathione S-transferase theta 1	Homo sapiens	129-134
26175060-2	2015	In the present study, we confirmed associations between schizophrenia and the common CNVs in the glutathione (GSH)-related genes GSTT1, DDTL, and GSTM1 using quantitative real-time polymerase chain reaction analyses of 620 patients with schizophrenia and in 622 controls.	Glutathione	110-113	glutathione S-transferase theta 1	Homo sapiens	129-134
25595865-5	2015	RESULTS: GSTM1 and GSTT1 deletion was found in 57% (53/93) and 18% (17/93), respectively, in healthy patients, while the OSCC group showed 57% (57/100) for GSTM1 deletion and 22% (22/100) with a deletion of GSTT1.	oscc	121-125	glutathione S-transferase theta 1	Homo sapiens	207-212
26404360-10	2015	The subjects with APOE rs429358 T/C + C/C and GSTT1- genotype were found to have the highest plasma TG level, erythrocyte CAT enzyme activity, and the lowest GST enzyme activity compared to subjects with other genotypes (p &lt; 0.05).	Triglycerides	100-102	glutathione S-transferase theta 1	Homo sapiens	46-51
26003511-0	2015	Association between null alleles of GSTM1 and GSTT1 and dependence to heroin and opium.	Heroin	70-76	glutathione S-transferase theta 1	Homo sapiens	46-51
26295386-0	2015	Genetic Polymorphisms of Glutathione-Related Enzymes (GSTM1, GSTT1, and GSTP1) and Schizophrenia Risk: A Meta-Analysis.	Glutathione	25-36	glutathione S-transferase theta 1	Homo sapiens	61-66
26179485-7	2015	White blood cell counts were also lower in workers with null-GSTT1 and null-GSTM after adjusting for age, gender, smoking, and alcohol consumption.	Alcohols	127-134	glutathione S-transferase theta 1	Homo sapiens	61-66
26179485-8	2015	CONCLUSION: Null-GSTT1 and null-GSTM1 genotypes and Cytochrome P4502E1 (CYP2E1: rs2031920, rs3813867) may support the hematotoxicity of benzene-exposed workers in China, and we can make use of it to select susceptible population.	Benzene	136-143	glutathione S-transferase theta 1	Homo sapiens	17-22
25876999-0	2015	Associations between the polymorphisms of GSTT1, GSTM1 and methylation of arsenic in the residents exposed to low-level arsenic in drinking water in China.	Arsenic	120-127	glutathione S-transferase theta 1	Homo sapiens	42-47
25876999-0	2015	Associations between the polymorphisms of GSTT1, GSTM1 and methylation of arsenic in the residents exposed to low-level arsenic in drinking water in China.	Water	140-145	glutathione S-transferase theta 1	Homo sapiens	42-47
25876999-1	2015	We carry out a study to analyze the relation between polymorphisms of GSTT1, GSTM1 and the capacity of arsenic methylation in a human population exposed to arsenic in drinking water.	Arsenic	103-110	glutathione S-transferase theta 1	Homo sapiens	70-75
25876999-1	2015	We carry out a study to analyze the relation between polymorphisms of GSTT1, GSTM1 and the capacity of arsenic methylation in a human population exposed to arsenic in drinking water.	Arsenic	156-163	glutathione S-transferase theta 1	Homo sapiens	70-75
25876999-2	2015	230 randomly chose subjects were divided into four subgroups based on the arsenic levels, and then the associations between the polymorphisms of GSTT1, GSTM1 and methylation of arsenic were investigated.	Arsenic	177-184	glutathione S-transferase theta 1	Homo sapiens	145-150
25876999-4	2015	Moreover, the levels of iAs and TAs in urine in the subjects with genotype of GSTM1(+) were significantly higher than those with GSTM1(-); the level of DMA in the subjects with GSTT1(+) and GSTM1(+) were higher than those with GSTT1(-) and GSTM1(-), although it is not statistically significant.	dma	152-155	glutathione S-transferase theta 1	Homo sapiens	177-182
25876999-6	2015	The levels of TAs in urine, together with the genotypes of GSTT1/GSTM1 were associated with the levels of MMA and DMA.	mma	106-109	glutathione S-transferase theta 1	Homo sapiens	59-64
25876999-6	2015	The levels of TAs in urine, together with the genotypes of GSTT1/GSTM1 were associated with the levels of MMA and DMA.	dma	114-117	glutathione S-transferase theta 1	Homo sapiens	59-64
25876999-7	2015	Our results suggested that the polymorphisms of GSTT1 and GSTM1 were associated with the methylation of arsenic, especially the levels of DMA and SMI.	Arsenic	104-111	glutathione S-transferase theta 1	Homo sapiens	48-53
25876999-7	2015	Our results suggested that the polymorphisms of GSTT1 and GSTM1 were associated with the methylation of arsenic, especially the levels of DMA and SMI.	dma	138-141	glutathione S-transferase theta 1	Homo sapiens	48-53
25648260-4	2015	Cross-talk was observed between one-carbon and xenobiotic pathways in breast cancer (RFC 80 G>A, COMT H108L and TYMS 5"-UTR 28 bp tandem repeat) and SLE (CYP1A1 m1, MTRR 66 A>G and GSTT1).	Carbon	36-42	glutathione S-transferase theta 1	Homo sapiens	181-186
25562543-2	2015	The aim of this work was to investigate the effects of polymorphic genes CYP2E1, EPHX1, GSTT1, and GSTM1 on the urinary concentrations of the styrene metabolites mandelic acid (MA), phenylglyoxylic acid (PGA) and on the concentration ratios between (MA+PGA) and urinary styrene (U-Sty) and airborne styrene (A-Sty), in 30 workers from two fiberglass-reinforced plastic manufacturing plants and 26 unexposed controls.	Styrene	142-149	glutathione S-transferase theta 1	Homo sapiens	88-93
26258094-2	2015	Detoxification of ROS is largely performed by Glutathione S-transferases (GSTs), therefore polymorphisms of GSTM1, GSTT1 and GSTP1 genes which decrease enzymes activity could affect SLE susceptibility.	Reactive Oxygen Species	18-21	glutathione S-transferase theta 1	Homo sapiens	115-120
25562543-2	2015	The aim of this work was to investigate the effects of polymorphic genes CYP2E1, EPHX1, GSTT1, and GSTM1 on the urinary concentrations of the styrene metabolites mandelic acid (MA), phenylglyoxylic acid (PGA) and on the concentration ratios between (MA+PGA) and urinary styrene (U-Sty) and airborne styrene (A-Sty), in 30 workers from two fiberglass-reinforced plastic manufacturing plants and 26 unexposed controls.	mandelic acid	162-175	glutathione S-transferase theta 1	Homo sapiens	88-93
26604430-6	2015	We report that GSTT1 null genotype is significantly associated with the risk of CD (OR: 2.5, CI: 1.2-5, P = 0.013) and UC (OR: 3.5, CI: 1.5-8.5, P = 0.004) and can influence Crohn"s disease behavior.	Cadmium	80-82	glutathione S-transferase theta 1	Homo sapiens	15-20
25678751-5	2015	In case of GSTT1 on the other hand, the decrease in diastolic pressure and lymphocyte DNA damage was observed in both null types and present types, but the erythrocyte catalase activity was decreased in GSTT1-null type and the plasma vitamin C level was increased in GSTT1-present type, suggesting that, the antioxidant effect of grape juice was greater in GSTT1-present type compared to GSTT1-null type.	Ascorbic Acid	234-243	glutathione S-transferase theta 1	Homo sapiens	11-16
25874030-4	2015	We analyzed the correlation between toluene metabolism and genetic diversity in glutathione S-transferase (GST) (M1), GSTT1, and cytochrome p-450 (CYP) 2E1*5 as well as lifestyle habits (smoking, drinking, and exercise habits).	Toluene	36-43	glutathione S-transferase theta 1	Homo sapiens	118-123
25874030-5	2015	The results revealed significant correlations between toluene metabolism and GSTM1 and GSTT1 genetic diversity, as well as smoking and exercise.	Toluene	54-61	glutathione S-transferase theta 1	Homo sapiens	87-92
25725180-4	2015	Genotypes of GSTM1 and GSTT1 null deletions were determined in 22 (53.7%) and 7 (17.1%) patients with PCAG and 34 (34%) and 15 (15%) in healthy participants.	pcag	102-106	glutathione S-transferase theta 1	Homo sapiens	23-28
25725180-5	2015	Comparison of patients and healthy ones regarding GSTM1 and GSTT1 genotypes revealed increase of GSTM1 null deletions genotypes" in patients with PCAG (P=0.03).	pcag	146-150	glutathione S-transferase theta 1	Homo sapiens	60-65
25432281-0	2014	Role of glutathione-S-transferase M1 (GSTM1) and T1 (GSTT1) genes in the development and progress of chronic myeloid leukemia and in the formation of response to imatinib therapy.	Imatinib Mesylate	162-170	glutathione S-transferase theta 1	Homo sapiens	53-58
27843993-0	2015	Association between GSTM1 and GSTT1 polymorphisms and susceptibility to methamphetamine dependence.	Methamphetamine	72-87	glutathione S-transferase theta 1	Homo sapiens	30-35
27843993-4	2015	The aim of the present study is to investigate the association between GSTM1 and GSTT1 polymorphisms and methamphetamine dependence.	Methamphetamine	105-120	glutathione S-transferase theta 1	Homo sapiens	81-86
25432281-3	2014	Combinations of the "zero" GSTM1 and GSTT1 genotypes were risk factors indicating the probable disease progress and failure of high cytogenetic response after 12 months of imatinib therapy (400 mg daily).	Imatinib Mesylate	172-180	glutathione S-transferase theta 1	Homo sapiens	37-42
25188725-0	2014	Dual glutathione-S-transferase-theta1 and -mu1 gene deletions determine imatinib failure in chronic myeloid leukemia.	Imatinib Mesylate	72-80	glutathione S-transferase theta 1	Homo sapiens	5-46
25188725-4	2014	Deletion of GSTT1 alone, or in combination with deletion of the GSTM1 gene, significantly increased the likelihood of imatinib failure (P = 0.021 and P &lt; 0.001, respectively).	Imatinib Mesylate	118-126	glutathione S-transferase theta 1	Homo sapiens	12-17
25188725-6	2014	Losses of the GSTT1 and GSTM1 genes are therefore important determinants of imatinib failure in CML.	Imatinib Mesylate	76-84	glutathione S-transferase theta 1	Homo sapiens	14-19
25447454-5	2014	As to susceptibility biomarkers, functional genetic polymorphisms of relevant biotransformation enzymes may modulate the risk of adverse effects (NQO1) and the levels of biomarkers of internal dose, in particular S-phenylmercapturic acid (GSTM1, GSTT1, GSTA1).	S-phenyl-N-acetylcysteine	213-237	glutathione S-transferase theta 1	Homo sapiens	246-251
24968062-5	2014	GSTT1 null polymorphism reduces the conjugation rate of benzene epoxide with GSH, and to a lesser extent also GSTTA1 mutant, GSTM1 null and NQO1 mutant genotypes.	benzene epoxide	56-71	glutathione S-transferase theta 1	Homo sapiens	0-5
24968062-5	2014	GSTT1 null polymorphism reduces the conjugation rate of benzene epoxide with GSH, and to a lesser extent also GSTTA1 mutant, GSTM1 null and NQO1 mutant genotypes.	Glutathione	77-80	glutathione S-transferase theta 1	Homo sapiens	0-5
25368399-10	2014	CONCLUSIONS: The difference in urinary MHBMA excretion levels from cigarette smoking across three ethnic groups is, in part, explained by the GSTT1 genotype.	mhbma	39-44	glutathione S-transferase theta 1	Homo sapiens	142-147
25420021-10	2014	RESULTS: Individual GSTM1 or GSTT1 gene deletion affects body antioxidant biomarkers levels, including erythrocyte GST activity, plasma total antioxidant capacity, and glutathione levels.	Glutathione	168-179	glutathione S-transferase theta 1	Homo sapiens	29-34
25368399-11	2014	Mean urinary MHBMA levels are higher in whites among GSTT1-null smokers.	mhbma	13-18	glutathione S-transferase theta 1	Homo sapiens	53-58
24913818-7	2014	Excretion of the benzene-derived mercapturic acid was higher in participants who were GSTT1-positive than in the null genotype, irrespective of study arm assignment.	Benzene	17-24	glutathione S-transferase theta 1	Homo sapiens	86-91
25165394-2	2014	Glutathione S-transferase (GST) M1 and GSTT1 metabolize isothiocyanates; genetic variants may result in differences in biologic response.	Isothiocyanates	56-71	glutathione S-transferase theta 1	Homo sapiens	39-44
24913818-7	2014	Excretion of the benzene-derived mercapturic acid was higher in participants who were GSTT1-positive than in the null genotype, irrespective of study arm assignment.	Acetylcysteine	33-49	glutathione S-transferase theta 1	Homo sapiens	86-91
24637631-2	2014	The primary hypothesis of this study was to identify whether the polymorphisms of two glutathione-S-transferase enzymes (GSTM1 and GSTT1 genes) predict an increased risk of mood and anxiety disorders in smokers with nicotine dependence.	Nicotine	216-224	glutathione S-transferase theta 1	Homo sapiens	131-136
24913811-4	2014	The present study aimed to examine the impact of GSTT1 and GSTM1 polymorphisms on the response to imatinib in patients with CML.	Imatinib Mesylate	98-106	glutathione S-transferase theta 1	Homo sapiens	49-54
24913811-10	2014	Moreover, the GSTT1 present/GSTM1 present appeared to be associated with a final dose of 600 or 800 mg of imatinib, but not significantly.	Imatinib Mesylate	106-114	glutathione S-transferase theta 1	Homo sapiens	14-19
30514013-2	2014	N-acetyltransferase 2 (NAT2), cytochrome P450 2E1 (CYP2E1) and glutathione S-transferase (loci GSTM1 and GSTT1) are involved in the metabolism of isoniazid, the most toxic drug for the treatment of tuberculosis (TB).	Isoniazid	146-155	glutathione S-transferase theta 1	Homo sapiens	105-110
24216264-11	2014	To find out the dependence of blood OCPs level on genotype, we carried out logistic regression analysis and results revealed that GSTM1(-)/GSTT1(-) genotype associated significantly with a number of OCPs namely gamma-HCH, p,p"-DDT and total pesticides.	Hexachlorocyclohexane	211-220	glutathione S-transferase theta 1	Homo sapiens	139-144
24685594-4	2014	RESULTS: In the cross-sectional study, GSTM1-null genotype and GSTT1-null genotype were associated with EAH in subjects with type 2 diabetes (59.0% vs. 50.3%, p=0.007; 28.5% vs. 20.7%, p=0.008; consequently).	eah	104-107	glutathione S-transferase theta 1	Homo sapiens	63-68
24685594-5	2014	CONCLUSION: After adjustment for age, body mass index, and hsCRP level, GSTM1-null and GSTT1-null genotypes were found to be independent risk factors for the development of EAH in Slovenian patients with type 2 diabetes.	eah	173-176	glutathione S-transferase theta 1	Homo sapiens	87-92
24593045-7	2014	The GSTT1 deletion was associated with a higher frequency of the NMPA to homozygous deletion (p = 0.008), GSTP1 + 313A &gt; G with a minor risk of osteoporosis (p = 0.036), and patient age &lt;= 154 months (p = 0.044) with the AA genotype.	nmpa	65-69	glutathione S-transferase theta 1	Homo sapiens	4-9
24586676-0	2014	GSTT1 deletion is related to polycyclic aromatic hydrocarbons-induced DNA damage and lymphoma progression.	Polycyclic Aromatic Hydrocarbons	29-61	glutathione S-transferase theta 1	Homo sapiens	0-5
24586676-3	2014	Here we investigated the molecular connection of the genetic polymorphism of GSTT1 to the response of lymphocytes to polycyclic aromatic hydrocarbons (PAH).	Polycyclic Aromatic Hydrocarbons	117-149	glutathione S-transferase theta 1	Homo sapiens	77-82
24586676-3	2014	Here we investigated the molecular connection of the genetic polymorphism of GSTT1 to the response of lymphocytes to polycyclic aromatic hydrocarbons (PAH).	Polycyclic Aromatic Hydrocarbons	151-154	glutathione S-transferase theta 1	Homo sapiens	77-82
24586676-6	2014	Mimicking environmental exposure using long-term repeat culture with low-dose PAH metabolite Hydroquinone, malignant B- and T-lymphocytes presented increased DNA damage, pCHK1/MYC expression and cell proliferation, which were counteracted by ectopic expression of GSTT1.	Polycyclic Aromatic Hydrocarbons	78-81	glutathione S-transferase theta 1	Homo sapiens	264-269
24586676-6	2014	Mimicking environmental exposure using long-term repeat culture with low-dose PAH metabolite Hydroquinone, malignant B- and T-lymphocytes presented increased DNA damage, pCHK1/MYC expression and cell proliferation, which were counteracted by ectopic expression of GSTT1.	hydroquinone	93-105	glutathione S-transferase theta 1	Homo sapiens	264-269
24586676-9	2014	Collectively, these findings suggested that GSTT1 deletion is related to genetic predisposition to lymphoma, particularly interacting with environmental pollutants containing PAH.	Polycyclic Aromatic Hydrocarbons	175-178	glutathione S-transferase theta 1	Homo sapiens	44-49
24967061-5	2014	RESULTS: GSTM1 and GSTT1 null deletions genotypes were determined in 22 (53.7%) and 7 (17.1%) patients with PCAG and 34 (34%) and 15 (15%) in healthy subjects.	pcag	108-112	glutathione S-transferase theta 1	Homo sapiens	19-24
24967061-6	2014	Comparison between patients and healthy subjects regarding GSTM1 and GSTT1 genotypes revealed increase of GSTM1 null deletions genotypes in patients with PCAG (P=0.03).	pcag	154-158	glutathione S-transferase theta 1	Homo sapiens	69-74
24216264-11	2014	To find out the dependence of blood OCPs level on genotype, we carried out logistic regression analysis and results revealed that GSTM1(-)/GSTT1(-) genotype associated significantly with a number of OCPs namely gamma-HCH, p,p"-DDT and total pesticides.	DDT	222-230	glutathione S-transferase theta 1	Homo sapiens	139-144
24696865-1	2014	This study aims to evaluate the effects of polymorphisms in glutathione (GSH-) related genes (GSTM1, GSTT1, GSTP1, GCLM, and GCLC) in the distribution of Hg in the blood compartments in humans exposed to methylmercury (MeHg).	Glutathione	60-71	glutathione S-transferase theta 1	Homo sapiens	101-106
24696865-1	2014	This study aims to evaluate the effects of polymorphisms in glutathione (GSH-) related genes (GSTM1, GSTT1, GSTP1, GCLM, and GCLC) in the distribution of Hg in the blood compartments in humans exposed to methylmercury (MeHg).	Glutathione	73-76	glutathione S-transferase theta 1	Homo sapiens	101-106
25790712-5	2014	CONCLUSION: Children with the neutrophilic phenotype of bronchial asthma having deletions in the GSTT1/GSTM1 system are characterized by bronchial hypersensitivity to histamine and dosed physical exercises.	Histamine	167-176	glutathione S-transferase theta 1	Homo sapiens	97-102
25306601-6	2014	Variable sensitivity to dioxins was demonstrated by associations of genetic polymorphism (CYP1A1, GSTM1, GSTT1, n = 195) and congenital morphogenetic variants among children (n = 1734).	Dioxins	24-31	glutathione S-transferase theta 1	Homo sapiens	105-110
23979980-1	2014	Glutathione S-transferase T1 (GSTT1) catalyzes reactions between glutathione and lipophilic compounds with electrophilic centers, leading to neutralization of toxic compounds, xenobiotics, and products of oxidative stress.	Glutathione	65-76	glutathione S-transferase theta 1	Homo sapiens	0-28
23979980-1	2014	Glutathione S-transferase T1 (GSTT1) catalyzes reactions between glutathione and lipophilic compounds with electrophilic centers, leading to neutralization of toxic compounds, xenobiotics, and products of oxidative stress.	Glutathione	65-76	glutathione S-transferase theta 1	Homo sapiens	30-35
23979980-8	2014	In addition, we found that cigarette smoking and alcohol drinking may modified the association of GSTT1 null genotypes with the risk of GC.	Alcohols	49-56	glutathione S-transferase theta 1	Homo sapiens	98-103
24908960-3	2014	In patients with neutrophilic BA and deletion polymorphism of genes GSTT1 and GSTM1, there was a tendency to decreasing of the bronchial lability index through the decrease of bronchodilation, and bronchial response to histamine occurred to be higher than in children with the absence of polymorphism of the referred genes of the xenobiotics biotransformation system.	Histamine	219-228	glutathione S-transferase theta 1	Homo sapiens	68-73
23888321-1	2014	Genetic polymorphisms in glutathione S-transferases M1 (GSTM1) and T1 (GSTT1) genes have been widely reported and considered to have a significant effect on prostate cancer (PCa) risk, but the results are inconsistent.	Glutathione	25-36	glutathione S-transferase theta 1	Homo sapiens	71-76
24098457-10	2013	In diabetic patients, GSTT1-null conferred higher levels of triglycerides and VLDL-cholesterol, while GSTM1-null was associated with increased levels of fasting blood glucose, glycated hemoglobin and blood pressure.	Triglycerides	60-73	glutathione S-transferase theta 1	Homo sapiens	22-27
24319713-0	2013	Role of cytochrome P450-dependent monooxygenases and polymorphic variants of GSTT1 and GSTM1 genes in the formation of brain lesions in individuals chronically exposed to mercury.	Mercury	171-178	glutathione S-transferase theta 1	Homo sapiens	77-82
24319713-4	2013	Inhibition of antipyrine metabolism, increased frequency of combination of GSTT1(0/0)/GSTM1(+) genotypes in patients with chronic mercury intoxication, and the specificity of cytochrome P450 inhibition with mercury suggest that disease progression is related to inhibition of cytochrome P450 isoforms in the brain that catalyze regulation of endogenous substrates.	Mercury	130-137	glutathione S-transferase theta 1	Homo sapiens	75-80
24370292-0	2013	[Association between GSTP1, GSTM1, GSTT1 genetic polymorphisms and urinary styrene phenyl hydroxyethyl mercapturic acids level].	styrene phenyl hydroxyethyl mercapturic acids	75-120	glutathione S-transferase theta 1	Homo sapiens	35-40
24370292-1	2013	OBJECTIVE: To investigate the relationship between genetic polymorphisms of glutathione S-transferase P1 (GSTP1), glutathione S-transferase M1 (GSTM1), and glutathione S-transferase T1 (GSTT1) and urinary level of mercapturic acids of styrene (PHEMAs) in workers exposed to styrene.	Acetylcysteine	214-231	glutathione S-transferase theta 1	Homo sapiens	156-184
24370292-1	2013	OBJECTIVE: To investigate the relationship between genetic polymorphisms of glutathione S-transferase P1 (GSTP1), glutathione S-transferase M1 (GSTM1), and glutathione S-transferase T1 (GSTT1) and urinary level of mercapturic acids of styrene (PHEMAs) in workers exposed to styrene.	Styrene	235-242	glutathione S-transferase theta 1	Homo sapiens	156-184
24370292-1	2013	OBJECTIVE: To investigate the relationship between genetic polymorphisms of glutathione S-transferase P1 (GSTP1), glutathione S-transferase M1 (GSTM1), and glutathione S-transferase T1 (GSTT1) and urinary level of mercapturic acids of styrene (PHEMAs) in workers exposed to styrene.	Polyhydroxyethyl Methacrylate	244-250	glutathione S-transferase theta 1	Homo sapiens	156-184
24370292-1	2013	OBJECTIVE: To investigate the relationship between genetic polymorphisms of glutathione S-transferase P1 (GSTP1), glutathione S-transferase M1 (GSTM1), and glutathione S-transferase T1 (GSTT1) and urinary level of mercapturic acids of styrene (PHEMAs) in workers exposed to styrene.	Styrene	274-281	glutathione S-transferase theta 1	Homo sapiens	156-184
24098457-10	2013	In diabetic patients, GSTT1-null conferred higher levels of triglycerides and VLDL-cholesterol, while GSTM1-null was associated with increased levels of fasting blood glucose, glycated hemoglobin and blood pressure.	Cholesterol	83-94	glutathione S-transferase theta 1	Homo sapiens	22-27
23827356-4	2013	The aims of the present study was to evaluate the effects of polymorphisms in glutathione (GSH)-related genes (GSTM1, GSTT1, GSTP1 and GCLM) on Hg concentrations in blood and hair, as well as MeHg-related effects on catalase (CAT) and glutathione-peroxidase (GPx) activity and GSH concentrations.	Glutathione	91-94	glutathione S-transferase theta 1	Homo sapiens	118-123
24124608-0	2013	GSTT1 copy number gain and ZNF overexpression are predictors of poor response to imatinib in gastrointestinal stromal tumors.	Imatinib Mesylate	81-89	glutathione S-transferase theta 1	Homo sapiens	0-5
24124608-7	2013	Surprisingly, all four malignant GISTs with KIT exon 11 deletion mutations with primary resistance to imatinib had an increased GSTT1 CN and mRNA expression level of GSTT1.	Imatinib Mesylate	102-110	glutathione S-transferase theta 1	Homo sapiens	128-133
24124608-7	2013	Surprisingly, all four malignant GISTs with KIT exon 11 deletion mutations with primary resistance to imatinib had an increased GSTT1 CN and mRNA expression level of GSTT1.	Imatinib Mesylate	102-110	glutathione S-transferase theta 1	Homo sapiens	166-171
24124608-8	2013	Increased mRNA expression of GSTT1 and ZNF could be predictors of a poor response to imatinib.	Imatinib Mesylate	85-93	glutathione S-transferase theta 1	Homo sapiens	29-34
23798465-9	2013	The association between AA and GSTT1 deletion suggests a role of glutathione-conjugation in AA, possibly through protecting the hematopoietic compartment from endogenous metabolites or environmental exposures.	Glutathione	65-76	glutathione S-transferase theta 1	Homo sapiens	31-36
24511153-7	2013	This data suggests that GSTT1 contributes to the observed variability in arsenic metabolism.	Arsenic	73-80	glutathione S-transferase theta 1	Homo sapiens	24-29
23817691-1	2013	Glutathione S-transferases (GSTs) enzymes are involved in conjugation of electrophilic compounds to glutathione, and glutathione S-transferase T 1 (GSTT1) and glutathione S-transferase M 1 (GSTM1) polymorphisms have been implicated as risk factors for prostate cancer.	Glutathione	100-111	glutathione S-transferase theta 1	Homo sapiens	148-153
24084344-0	2013	Cytogenetic damage in Turkish coke oven workers exposed to polycyclic aromatic hydrocarbons: Association with CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, and GSTP1 gene polymorphisms.	Polycyclic Aromatic Hydrocarbons	59-91	glutathione S-transferase theta 1	Homo sapiens	140-145
23810248-12	2013	CONCLUSIONS: The GSTM1-null genotype plays an important role in genetic susceptibility to MIBC and the GSTT1-null genotype is associated with disease progression and shorter survival in MIBC.	4-METHYL-2-PENTANOL	186-190	glutathione S-transferase theta 1	Homo sapiens	103-108
24511153-0	2013	Influence of GSTT1 Genetic Polymorphisms on Arsenic Metabolism.	Arsenic	44-51	glutathione S-transferase theta 1	Homo sapiens	13-18
24511153-5	2013	A significant gene-environment interaction was observed between urinary arsenic exposure in drinking water GSTT1 but not GSTM1 where GSTT1 null individuals had a slightly higher excretion rate of arsenic compared to GSTT1 wildtypes after adjusting for other factors.	Arsenic	72-79	glutathione S-transferase theta 1	Homo sapiens	107-112
24511153-8	2013	Since individuals with a higher primary methylation index and lower secondary methylation index are more susceptible to arsenic related disease, these results suggest that GSTT1 null individuals may be more susceptible to arsenic-related toxicity.	Arsenic	120-127	glutathione S-transferase theta 1	Homo sapiens	172-177
24511153-5	2013	A significant gene-environment interaction was observed between urinary arsenic exposure in drinking water GSTT1 but not GSTM1 where GSTT1 null individuals had a slightly higher excretion rate of arsenic compared to GSTT1 wildtypes after adjusting for other factors.	Arsenic	196-203	glutathione S-transferase theta 1	Homo sapiens	133-138
24511153-5	2013	A significant gene-environment interaction was observed between urinary arsenic exposure in drinking water GSTT1 but not GSTM1 where GSTT1 null individuals had a slightly higher excretion rate of arsenic compared to GSTT1 wildtypes after adjusting for other factors.	Arsenic	196-203	glutathione S-transferase theta 1	Homo sapiens	133-138
24511153-8	2013	Since individuals with a higher primary methylation index and lower secondary methylation index are more susceptible to arsenic related disease, these results suggest that GSTT1 null individuals may be more susceptible to arsenic-related toxicity.	Arsenic	222-229	glutathione S-transferase theta 1	Homo sapiens	172-177
23845145-3	2013	We aimed to examine whether gene polymorphisms in GSTM1, GSTT1 and TPMT, combined with various clinical parameters, can predict thiopurine induced SAE.	2-mercaptopyrazine	128-138	glutathione S-transferase theta 1	Homo sapiens	57-62
23845145-3	2013	We aimed to examine whether gene polymorphisms in GSTM1, GSTT1 and TPMT, combined with various clinical parameters, can predict thiopurine induced SAE.	SELENAZOLE-4-CARBOXYAMIDE-ADENINE DINUCLEOTIDE	147-150	glutathione S-transferase theta 1	Homo sapiens	57-62
23422534-7	2013	Two weeks on the high fruit-juice and vegetable diet increased GST and GR activities in the GSTM1+/GSTT1+ group (P &lt; 0.05 compared with baseline or GSTM1-/GSTT1- group), although no effects were observed on GST and GR activities in GSTM1-/GSTT1- participants.	juice	28-33	glutathione S-transferase theta 1	Homo sapiens	99-104
23422534-7	2013	Two weeks on the high fruit-juice and vegetable diet increased GST and GR activities in the GSTM1+/GSTT1+ group (P &lt; 0.05 compared with baseline or GSTM1-/GSTT1- group), although no effects were observed on GST and GR activities in GSTM1-/GSTT1- participants.	juice	28-33	glutathione S-transferase theta 1	Homo sapiens	158-163
23422534-7	2013	Two weeks on the high fruit-juice and vegetable diet increased GST and GR activities in the GSTM1+/GSTT1+ group (P &lt; 0.05 compared with baseline or GSTM1-/GSTT1- group), although no effects were observed on GST and GR activities in GSTM1-/GSTT1- participants.	juice	28-33	glutathione S-transferase theta 1	Homo sapiens	158-163
23506349-8	2013	Gstm1- and Gstt1-null mice have potential as human models, since null genotypes of GSTM1/Gstm1 and GSTT1/Gstt1 decreased hepatic GST activities toward p-nitrobenzyl chloride and dichloromethane, respectively, in both humans and mice.	4-nitrobenzyl chloride	151-173	glutathione S-transferase theta 1	Homo sapiens	99-104
23506349-8	2013	Gstm1- and Gstt1-null mice have potential as human models, since null genotypes of GSTM1/Gstm1 and GSTT1/Gstt1 decreased hepatic GST activities toward p-nitrobenzyl chloride and dichloromethane, respectively, in both humans and mice.	4-nitrobenzyl chloride	151-173	glutathione S-transferase theta 1	Homo sapiens	105-110
23506349-8	2013	Gstm1- and Gstt1-null mice have potential as human models, since null genotypes of GSTM1/Gstm1 and GSTT1/Gstt1 decreased hepatic GST activities toward p-nitrobenzyl chloride and dichloromethane, respectively, in both humans and mice.	Methylene Chloride	178-193	glutathione S-transferase theta 1	Homo sapiens	99-104
23506349-8	2013	Gstm1- and Gstt1-null mice have potential as human models, since null genotypes of GSTM1/Gstm1 and GSTT1/Gstt1 decreased hepatic GST activities toward p-nitrobenzyl chloride and dichloromethane, respectively, in both humans and mice.	Methylene Chloride	178-193	glutathione S-transferase theta 1	Homo sapiens	105-110
23330093-0	2012	Dependence of blood levels of HSP70 and HSP90 on genotypes of HSP70, GSTT1, and GSTM1 gene polymorphism in individuals chronically exposed to mercury.	Mercury	142-149	glutathione S-transferase theta 1	Homo sapiens	69-74
23765968-0	2013	Influence of GSTM1 and GSTT1 polymorphisms on the survival rate of patients with malignant glioma under perillyl alcohol-based therapy.	perillyl alcohol	104-120	glutathione S-transferase theta 1	Homo sapiens	23-28
23765968-3	2013	We made an explorative study of a Brazilian population with malignant glioma to determine whether GSTM1 and GSTT1 genetic polymorphisms influence the response to intranasal administration of perillyl alcohol and the survival rate.	perillyl alcohol	191-207	glutathione S-transferase theta 1	Homo sapiens	108-113
23765968-10	2013	A significantly lower frequency of GSTT1 deletion in glioma patients compared to healthy controls indicates that GSTT1 deletion may exert a protective role against gliomagenesis, influence therapeutic response to intranasal perillyl alcohol treatment, and increase overall survival, especially considering tumor topography.	perillyl alcohol	224-240	glutathione S-transferase theta 1	Homo sapiens	35-40
23765968-10	2013	A significantly lower frequency of GSTT1 deletion in glioma patients compared to healthy controls indicates that GSTT1 deletion may exert a protective role against gliomagenesis, influence therapeutic response to intranasal perillyl alcohol treatment, and increase overall survival, especially considering tumor topography.	perillyl alcohol	224-240	glutathione S-transferase theta 1	Homo sapiens	113-118
24083736-4	2013	The homozygous null deletion of phase II metabolic gene GSTT1 that abolishes its xenobiotic- detoxifying ability may be associated with carboplatin toxicity.	Carboplatin	136-147	glutathione S-transferase theta 1	Homo sapiens	56-61
24240585-10	2013	Multiple regression analysis revealed a significant interaction between beta-HCH and GSTM1&lt;formula&gt;^{-}&lt;/formula&gt; genotype (p&lt; 0.05) as well as in beta-HCH and GSTT1&lt;formula&gt;^{-}&lt;/formula&gt; genotype (p&lt; 0.05) respectively.	alpha-hexachlorocyclohexane	72-80	glutathione S-transferase theta 1	Homo sapiens	175-180
23287989-3	2013	Glutathione has an important role in the defence system, catalysed by glutathione S-transferase (GST), including two non-enzyme producing polymorphisms (GSTM1-null and GSTT1-null).	Glutathione	0-11	glutathione S-transferase theta 1	Homo sapiens	168-173
23099118-8	2013	Moreover, increased post-treatment ALT, AST and total bilirubin were associated with GSTM1*1/GSTT1*1 genotypes (p&lt;0.05).	Bilirubin	54-63	glutathione S-transferase theta 1	Homo sapiens	93-98
24266295-6	2013	Enzyme CYP P450 1A1, which is encoded by the CYP1A1 gene, is vital in the monooxygenation of lipofilic substrates, while GSTM1 and GSTT1 are the most abundant isophorms that conjugate and neutralize oxygen products.	lipofilic	93-102	glutathione S-transferase theta 1	Homo sapiens	131-136
24266295-6	2013	Enzyme CYP P450 1A1, which is encoded by the CYP1A1 gene, is vital in the monooxygenation of lipofilic substrates, while GSTM1 and GSTT1 are the most abundant isophorms that conjugate and neutralize oxygen products.	Oxygen	78-84	glutathione S-transferase theta 1	Homo sapiens	131-136
22954400-8	2012	GSTT1 was up to ten times more active than CYP 2E1 in both cell lines, indicating that potential lung damage is due to formation of pro-carcinogens such as formaldehyde.	Formaldehyde	156-168	glutathione S-transferase theta 1	Homo sapiens	0-5
23259321-8	2012	Elevated 8-oxodG levels were observed in subjects with CYP1A1 CAC haplotype and GSTT1 null variant.	8-ohdg	9-16	glutathione S-transferase theta 1	Homo sapiens	80-85
23045187-12	2012	In men with functional GSTT1, the odds ratio (OR) for association of PD with paraquat use was 1.5 (95% confidence interval [CI]: 0.6-3.6); in men with GSTT1*0, the OR was 11.1 (95% CI: 3.0-44.6; P interaction: 0.027).	Paraquat	77-85	glutathione S-transferase theta 1	Homo sapiens	23-28
22841242-12	2012	Anti-GSTT1 antibody was observed more frequently albeit not significantly, among the cyclosporine versus tacrolimus patient group (P = .16).	Cyclosporine	85-97	glutathione S-transferase theta 1	Homo sapiens	5-10
21300142-5	2012	Results showed that occupational exposure to benzene was negligible compared to that from smoking and confirmed the modulating effect of the genetic polymorphism of GSTT1 on the urinary excretion of SPMA, but not of t, t-MA, even at very low levels of benzene exposure.	Benzene	45-52	glutathione S-transferase theta 1	Homo sapiens	165-170
21300142-5	2012	Results showed that occupational exposure to benzene was negligible compared to that from smoking and confirmed the modulating effect of the genetic polymorphism of GSTT1 on the urinary excretion of SPMA, but not of t, t-MA, even at very low levels of benzene exposure.	Benzene	252-259	glutathione S-transferase theta 1	Homo sapiens	165-170
22052985-4	2012	Specifically, GSTM1 and GSTT1 genes are polymorphically deleted, the polymorphism GSTP1 c.313A&gt;G (rs1695) determines the amino acid substitution Ile105Val, where the Val-containing enzyme has reduced activity.	Valine	154-157	glutathione S-transferase theta 1	Homo sapiens	24-29
22052985-4	2012	Specifically, GSTM1 and GSTT1 genes are polymorphically deleted, the polymorphism GSTP1 c.313A&gt;G (rs1695) determines the amino acid substitution Ile105Val, where the Val-containing enzyme has reduced activity.	ile105val	148-157	glutathione S-transferase theta 1	Homo sapiens	24-29
22841242-12	2012	Anti-GSTT1 antibody was observed more frequently albeit not significantly, among the cyclosporine versus tacrolimus patient group (P = .16).	Tacrolimus	105-115	glutathione S-transferase theta 1	Homo sapiens	5-10
22445468-0	2012	GSTT1 gene abnormality in minimal change nephrotic syndrome with elevated serum immunoglobulin E. INTRODUCTION: Imbalance between T-helper 1 (Th1) and 2 (Th2) lymphocytes and effects of reactive oxygen species (ROS) upon glomerular capillary walls have been implicated in minimal change nephrotic syndrome (MCNS).	Reactive Oxygen Species	186-209	glutathione S-transferase theta 1	Homo sapiens	0-5
22251241-1	2012	BACKGROUND: Glutathione S-transferases (GSTs) GSTM1, GSTT1 and GSTP1 are multifunctional enzymes involved in the detoxification of a wide range of reactive oxygen species produced during melanin synthesis and oxidative stress processes.	Reactive Oxygen Species	147-170	glutathione S-transferase theta 1	Homo sapiens	53-58
22251241-1	2012	BACKGROUND: Glutathione S-transferases (GSTs) GSTM1, GSTT1 and GSTP1 are multifunctional enzymes involved in the detoxification of a wide range of reactive oxygen species produced during melanin synthesis and oxidative stress processes.	Melanins	187-194	glutathione S-transferase theta 1	Homo sapiens	53-58
22300440-6	2012	Also, CYP19A1 arginine allele in homozygosity or heterozygosity (TC/CC) was associated with a significant increased risk for breast cancer when associated to GSTM1 null genotype (OR=6.158; 95% CI=2.676-14.171; p&lt;0.001) and GSTT1 null genotype (OR=4.870; 95% CI=2.216-10.700; p&lt;0.001).	Arginine	14-22	glutathione S-transferase theta 1	Homo sapiens	226-231
21557334-7	2012	Flavonols and flavanols (EGC in particular) were associated with a reduced risk of breast cancer among those null for GSTM1 and GSTT1, with a P-value of 0.04 for the interaction between EGC and GSTM1 polymorphism.	Flavonols	0-9	glutathione S-transferase theta 1	Homo sapiens	128-133
21557334-7	2012	Flavonols and flavanols (EGC in particular) were associated with a reduced risk of breast cancer among those null for GSTM1 and GSTT1, with a P-value of 0.04 for the interaction between EGC and GSTM1 polymorphism.	flavanols	14-23	glutathione S-transferase theta 1	Homo sapiens	128-133
21557334-7	2012	Flavonols and flavanols (EGC in particular) were associated with a reduced risk of breast cancer among those null for GSTM1 and GSTT1, with a P-value of 0.04 for the interaction between EGC and GSTM1 polymorphism.	gallocatechol	25-28	glutathione S-transferase theta 1	Homo sapiens	128-133
21557334-8	2012	In contrast, among women possessing both GSTM1 and GSTT1, breast cancer risk increased with levels of flavonols, particularly kaempferol.	Flavonols	102-111	glutathione S-transferase theta 1	Homo sapiens	51-56
21557334-8	2012	In contrast, among women possessing both GSTM1 and GSTT1, breast cancer risk increased with levels of flavonols, particularly kaempferol.	kaempferol	126-136	glutathione S-transferase theta 1	Homo sapiens	51-56
22445468-0	2012	GSTT1 gene abnormality in minimal change nephrotic syndrome with elevated serum immunoglobulin E. INTRODUCTION: Imbalance between T-helper 1 (Th1) and 2 (Th2) lymphocytes and effects of reactive oxygen species (ROS) upon glomerular capillary walls have been implicated in minimal change nephrotic syndrome (MCNS).	Reactive Oxygen Species	211-214	glutathione S-transferase theta 1	Homo sapiens	0-5
22445468-1	2012	METHODS: By polymerase chain reaction and comparative genomic hybridization, we evaluated mutations of the GSTT1 gene (GSTT1), a member of the glutathione S-transferase (GST) supergene family associated with both protection of cells from ROS and control of allergic reactions and serum immunoglobulin (Ig) E.	Reactive Oxygen Species	238-241	glutathione S-transferase theta 1	Homo sapiens	107-112
22445468-1	2012	METHODS: By polymerase chain reaction and comparative genomic hybridization, we evaluated mutations of the GSTT1 gene (GSTT1), a member of the glutathione S-transferase (GST) supergene family associated with both protection of cells from ROS and control of allergic reactions and serum immunoglobulin (Ig) E.	Reactive Oxygen Species	238-241	glutathione S-transferase theta 1	Homo sapiens	119-124
22310945-9	2012	When interaction between GSTM1/GSTT1 genes polymorphism-OCPs levels and birth weight (gene-environment interaction) was ascertained, a significant association was seen between beta-HCH and GSTM1- genotype with reduction in birth weight of 213g.	beta-hexachlorocyclohexane	176-184	glutathione S-transferase theta 1	Homo sapiens	31-36
22153878-6	2012	Furthermore the genetic polymorphism of glutathione-S-transferase (GST) may be related to health effects of benzene exposure, in fact both genotype T1 (GSTT1) and M1 (GSTM1) are involved in the detoxification of benzene oxide.	Benzene	108-115	glutathione S-transferase theta 1	Homo sapiens	152-157
22153878-6	2012	Furthermore the genetic polymorphism of glutathione-S-transferase (GST) may be related to health effects of benzene exposure, in fact both genotype T1 (GSTT1) and M1 (GSTM1) are involved in the detoxification of benzene oxide.	benzene oxide	212-225	glutathione S-transferase theta 1	Homo sapiens	152-157
22537952-1	2012	OBJECTIVE: To study the relationship between glutathione S-transferase genes GSTT1 and GSTM1 polymorphisms and the susceptibility to infectious mononucleosis (IM) and acute lymphocytic leukemia (ALL) in children.	Glutathione	45-56	glutathione S-transferase theta 1	Homo sapiens	77-82
22170331-3	2012	In addition, in liver with GSTT1/Gstt1-null genotype, GST activity toward dichloromethane (DCM) was significantly decreased in both humans and mice.	Methylene Chloride	74-89	glutathione S-transferase theta 1	Homo sapiens	27-32
21896242-8	2012	There was correlation between plasma T-AOC and consumption of F&amp;V in the GSTM1- or GSTT1+ subjects.	Adenosine Monophosphate	64-67	glutathione S-transferase theta 1	Homo sapiens	87-92
21896242-12	2012	The erythrocyte GST activity was more sensitive to consumption of F&amp;V in the individuals with the GSTM1-/GSTT1+ genotype.	f&amp	66-71	glutathione S-transferase theta 1	Homo sapiens	109-114
22170331-3	2012	In addition, in liver with GSTT1/Gstt1-null genotype, GST activity toward dichloromethane (DCM) was significantly decreased in both humans and mice.	Methylene Chloride	74-89	glutathione S-transferase theta 1	Homo sapiens	33-38
22938433-2	2012	Thie present meta-analysis aimed to quantify the strength of the association between GSTT1 null genotype and risk of prostate cancer.	thie	0-4	glutathione S-transferase theta 1	Homo sapiens	85-90
22116675-5	2012	RESULTS: Among the six candidate polymorphisms, only the distribution frequency of GSTT1 null genotype was significantly higher among AAN cases compared with controls (P = 0.041, 62.6% vs. 48.7%) and was associated with a 1.7-fold increased risk (OR = 1.728, 95%CI: 1.013-2.948, P = 0.045) of developing AAN, after adjustment for age and gender.	4-nitrophenylacetic acid	134-137	glutathione S-transferase theta 1	Homo sapiens	83-88
22116675-5	2012	RESULTS: Among the six candidate polymorphisms, only the distribution frequency of GSTT1 null genotype was significantly higher among AAN cases compared with controls (P = 0.041, 62.6% vs. 48.7%) and was associated with a 1.7-fold increased risk (OR = 1.728, 95%CI: 1.013-2.948, P = 0.045) of developing AAN, after adjustment for age and gender.	4-nitrophenylacetic acid	304-307	glutathione S-transferase theta 1	Homo sapiens	83-88
22136492-3	2012	In addition, GST-T1 and GST-M1 null genotypes have been shown to be responsible for interindividual variations in the metabolism of arsenic, a known human carcinogen.	Arsenic	132-139	glutathione S-transferase theta 1	Homo sapiens	13-30
21914835-1	2011	Null mutation of glutathione transferase (GST) M1 and GSTT1 was reported to correlate statistically with an abnormal increase in the plasma levels of alanine aminotransferase or aspartate aminotransferase caused by troglitazone in diabetic patients (Clin Pharmacol Ther, 73:435-455, 2003).	Troglitazone	215-227	glutathione S-transferase theta 1	Homo sapiens	54-59
21997310-3	2012	Polymorphisms of the GSTM1 and GSTT1 genes may affect ligandin functions that are important in bilirubin transportation.	Bilirubin	95-104	glutathione S-transferase theta 1	Homo sapiens	31-36
22207314-5	2011	An inhibitor of MK2, a downstream regulator of p38, also diminished H(2)O(2)-induced GSTT1 upregulation.	)o(2)	71-76	glutathione S-transferase theta 1	Homo sapiens	85-90
22175791-0	2012	The role of the glutathione S-transferase genes GSTT1, GSTM1, and GSTP1 in acetaminophen-poisoned patients.	Glutathione	16-27	glutathione S-transferase theta 1	Homo sapiens	48-53
22175791-0	2012	The role of the glutathione S-transferase genes GSTT1, GSTM1, and GSTP1 in acetaminophen-poisoned patients.	Acetaminophen	75-88	glutathione S-transferase theta 1	Homo sapiens	48-53
22291700-8	2012	GSTP1/GSTT1 and GSTP1/GSTM1 combinations showed significantly associated with increase in blood Cd levels.	Cadmium	96-98	glutathione S-transferase theta 1	Homo sapiens	6-11
22291700-9	2012	This study indicated that polymorphisms of GSTP1 combined with GSTT1 and/or GSTM1 deletion are likely to influence on individual susceptibility to cadmium toxicity.	Cadmium	147-154	glutathione S-transferase theta 1	Homo sapiens	63-68
22724567-8	2012	RESULTS: We have demonstrated association of early onset of cisplatin induced hearing impairment with absence of null allele of GSTT1 (p = 0.009).	Cisplatin	60-69	glutathione S-transferase theta 1	Homo sapiens	128-133
22724567-10	2012	CONCLUSION: Early onset of cisplatin induced hearing impairment is more probable in persons with two functional alleles of GSTT1 gene.	Cisplatin	27-36	glutathione S-transferase theta 1	Homo sapiens	123-128
23049400-3	2012	OBJECTIVE: The aim of this study was to estimate the frequency of the GSTM1 and GSTT1 genotypes in sickle cell disease patients and their effect on iron status.	Iron	148-152	glutathione S-transferase theta 1	Homo sapiens	80-85
21914835-2	2011	This clinical evidence leads to the hypothesis that GSH conjugation catalyzed by GSTT1 and GSTM1 has a role in the elimination of reactive metabolites of troglitazone.	Glutathione	52-55	glutathione S-transferase theta 1	Homo sapiens	81-86
21914835-2	2011	This clinical evidence leads to the hypothesis that GSH conjugation catalyzed by GSTT1 and GSTM1 has a role in the elimination of reactive metabolites of troglitazone.	Troglitazone	154-166	glutathione S-transferase theta 1	Homo sapiens	81-86
21813807-0	2011	Serum vitamin C and other biomarkers differ by genotype of phase 2 enzyme genes GSTM1 and GSTT1.	Ascorbic Acid	6-15	glutathione S-transferase theta 1	Homo sapiens	90-95
21961652-3	2011	The NKA, post-exposure breath naphthalene, and male gender were associated with an increase, while CYP2E1*6 DD and GSTT1-plus (++/+-) genotypes were associated with a decrease in urine naphthalene level (p &lt; 0.0001).	naphthalene	185-196	glutathione S-transferase theta 1	Homo sapiens	115-120
22058002-9	2011	Additionally, patients with the GSTT1-null genotype had higher levels of triglycerides and very low-density lipoprotein cholesterol compared to those with the GSTT1-present genotype.	Triglycerides	73-86	glutathione S-transferase theta 1	Homo sapiens	32-37
21781954-1	2011	Glutathione transferase T1-1 catalyses detoxication and bioactivation processes in which glutathione conjugates are formed from endogenous and xenobiotic substrates, including alkylating agents and halogenated alkanes.	Glutathione	89-100	glutathione S-transferase theta 1	Homo sapiens	0-28
21781954-1	2011	Glutathione transferase T1-1 catalyses detoxication and bioactivation processes in which glutathione conjugates are formed from endogenous and xenobiotic substrates, including alkylating agents and halogenated alkanes.	Alkanes	210-217	glutathione S-transferase theta 1	Homo sapiens	0-28
21504230-11	2011	In the range of MC tested concentrations used (0.25-50 muM) GSTT1-1 and A1-1 showed a typical saturation curve with similar affinity for MC-LR ( 80 muM; k(cat) values 0.18 and 0.10 min(-1), respectively), A3-3 and M1-1 were linear, whereas GSTP1-1 showed a temperature-dependent sigmoidal allosteric curve with a k(cat) = 0.11 min(-1).	Microcystins	16-18	glutathione S-transferase theta 1	Homo sapiens	60-67
21435719-4	2011	Finally, polymorphism in GSTT1 (rs4630) was associated with a lower frequency of thalidomide-induced peripheral neuropathy (p=0.04).	Thalidomide	81-92	glutathione S-transferase theta 1	Homo sapiens	25-30
21798077-7	2011	Among the subjects with cumulative arsenic exposure (CAE) &gt;= 20 mg/L*year, the GSTT1 null genotype conferred a significantly increased cancer risk (RR, 3.25, 95% CI, 1.20-8.80).	Arsenic	35-42	glutathione S-transferase theta 1	Homo sapiens	82-87
21798077-8	2011	The gene-environment interaction between the GSTT1 and high arsenic exposure with respect to cancer risk was statistically significant (multiplicative model, p = 0.0151) and etiologic fraction was as high as 0.86 (95% CI, 0.51-1.22).	Arsenic	60-67	glutathione S-transferase theta 1	Homo sapiens	45-50
21798077-12	2011	The genetic effects of GSTT1 and GSTO1 on arsenic-induced urothelial carcinogenesis are largely confined to very high exposure level.	Arsenic	42-49	glutathione S-transferase theta 1	Homo sapiens	23-28
21152927-7	2011	Vitamin C levels varied according to GSTM1 polymorphism in the whole group (p &lt; 0.05), in all reference subjects (p &lt; 0.05), in the asbestos factory reference group (p &lt; 0.05), and according to GSTT1 polymorphism in reference group of the rock wool plant (p &lt; 0.05).	Ascorbic Acid	0-9	glutathione S-transferase theta 1	Homo sapiens	203-208
21511944-1	2011	The double null mutation of glutathione transferase, GSTM1 and GSTT1, is reported to influence troglitazone-associated abnormal increases of alanine aminotransferase and aspartate aminotransferase.	Troglitazone	95-107	glutathione S-transferase theta 1	Homo sapiens	63-68
21511944-6	2011	However, the CBLs of troglitazone in GSTM1/GSTT1 wild-type hepatocytes were unexpectedly higher than those in null hepatocytes.	Troglitazone	21-33	glutathione S-transferase theta 1	Homo sapiens	43-48
21511944-7	2011	Although this discrepancy has not been fully explained, the GSTM1 and GSTT1 null mutations increased the cytotoxicity of troglitazone, independent of CYP3A or CYP2C8 activities.	Troglitazone	121-133	glutathione S-transferase theta 1	Homo sapiens	70-75
21425430-3	2011	In our patients, DNIH was always preceded by the production of donor-specific antibodies against the glutathione S-transferase T1 (GSTT1) enzyme because of a genetic mismatch in which the donors carried the wild-type gene and the recipients displayed the null genotype.	dnih	17-21	glutathione S-transferase theta 1	Homo sapiens	101-129
21425430-3	2011	In our patients, DNIH was always preceded by the production of donor-specific antibodies against the glutathione S-transferase T1 (GSTT1) enzyme because of a genetic mismatch in which the donors carried the wild-type gene and the recipients displayed the null genotype.	dnih	17-21	glutathione S-transferase theta 1	Homo sapiens	131-136
21425430-4	2011	Complement component 4d (C4d) immunopositivity in 12 paraffin-embedded liver biopsy samples from 8 patients diagnosed with DNIH associated with anti-GSTT1 antibodies was retrospectively evaluated.	dnih	123-127	glutathione S-transferase theta 1	Homo sapiens	149-154
21504230-11	2011	In the range of MC tested concentrations used (0.25-50 muM) GSTT1-1 and A1-1 showed a typical saturation curve with similar affinity for MC-LR ( 80 muM; k(cat) values 0.18 and 0.10 min(-1), respectively), A3-3 and M1-1 were linear, whereas GSTP1-1 showed a temperature-dependent sigmoidal allosteric curve with a k(cat) = 0.11 min(-1).	cyanoginosin LR	137-142	glutathione S-transferase theta 1	Homo sapiens	60-67
22874804-4	2011	The analysis of the gene-gene interaction between GSTs indicated that the magnitude of the association was greater for the combined AG/GSTT1 &amp; GSTM1 genotypes (OR = 2.51; 95% CI: 1.13-5.63, P = 0.02).	Adenosine Monophosphate	142-145	glutathione S-transferase theta 1	Homo sapiens	135-140
21093063-3	2011	We found that the combination of the absence of GSTM1 gene with the of the GSTM1 gene with the polymorphism GSTA1*B/*B, and the presence of the GSTT1 gene, represents a risk factor for schizophrenia, indicating that the combination of different GST polymorphisms has a role in the predisposition to schizophrenia, probably affecting the capacity of the cell to detoxify the oxidized metabolites of catecholamines.	Catecholamines	398-412	glutathione S-transferase theta 1	Homo sapiens	144-149
21178300-2	2011	Statistically, double null genotype of glutathione S-transferase isoforms, GSTT1 and GSTM1, was a risk factor, indicating a low activity of the susceptible patients in scavenging chemically reactive metabolites.	Glutathione	39-50	glutathione S-transferase theta 1	Homo sapiens	75-80
21431478-2	2011	The aim of this study was to establish whether there is an association between the polymorphism of GSTM1 and GSTT1 and response to NACT.	nact	131-135	glutathione S-transferase theta 1	Homo sapiens	109-114
21234761-2	2011	We evaluated the influence of common polymorphisms related to DNA repair or xenobiotic pathway (XRCC1, GSTP1, GSTT1, and GSTM1) on the individual susceptibility to CIHM status in the non-neoplastic rectal mucosa in UC patients.	cihm	164-168	glutathione S-transferase theta 1	Homo sapiens	110-115
21352813-14	2011	Although the GSTM1-null polymorphism showed no correlation with lipid profiles among T2DM and T2DM with CAD patients, GSTT1-null polymorphism attained a statistical significance for the level of LDL (127+-28.20 vs. 134+-29.10; P=0.039) and triglycerides in T2DM with CAD patients (182.10+-21.10 vs. 191.20+-24.10; P=0.018).	Triglycerides	240-253	glutathione S-transferase theta 1	Homo sapiens	118-123
20488846-0	2011	Modification of the relationship between urinary 8-OHdG and hippuric acid concentration by GSTM1, GSTT1, and ALDH2 genotypes.	8-ohdg	49-55	glutathione S-transferase theta 1	Homo sapiens	98-103
20488846-9	2011	This study shows that the relationship between urinary HA and 8-OHdG concentration is modified by genetic polymorphisms of some metabolizing enzymes such as GSTM1, GSTT1, and ALDH2.	8-ohdg	62-68	glutathione S-transferase theta 1	Homo sapiens	164-169
21097530-7	2011	In conclusion, polymorphisms of GSTT1, EPHX1, MTHFR, MTR and NAT2 differentially affect the frequency of CTAs, CSAs and CTGs, showing interaction with smoking and age.	csas	111-115	glutathione S-transferase theta 1	Homo sapiens	32-37
21097530-7	2011	In conclusion, polymorphisms of GSTT1, EPHX1, MTHFR, MTR and NAT2 differentially affect the frequency of CTAs, CSAs and CTGs, showing interaction with smoking and age.	ctgs	120-124	glutathione S-transferase theta 1	Homo sapiens	32-37
21619788-5	2011	After controlling potential confounders, decreased excretion of urinary 1-OHP was associated with GSTP1 I105V AG + GG genotype in coke oven workers (single-gene model, P = 0.012; multi-gene model, P = 0.011) and with GSTT1 null type in the analysis including all subjects (P = 0.055 in both single-gene and multi-gene models).	Oxaliplatin	72-77	glutathione S-transferase theta 1	Homo sapiens	217-222
21734345-9	2011	Combination of 113His/His EPHX1/null-GSTM1 genotypes showed a significant association with the decrease of Delta FEV1 in patients (P =0.028).In conclusion, our results suggest combined EPHX1, GSTP1, GSTM1 and GSTT1 genetic polymorphisms may play a significant role in the development of COPD, emphysema and decline of the lung function.	113his	15-21	glutathione S-transferase theta 1	Homo sapiens	209-214
20300859-0	2011	Serum testosterone in females exposed to natural sour gas with respect to polymorphisms of XRCC1, GSTM1, and GSTT1.	Testosterone	6-18	glutathione S-transferase theta 1	Homo sapiens	109-114
20300859-1	2011	The present study was done to determine the modulation effect(s) of polymorphisms of XRCC1, GSTM1, and GSTT1 on concentration of serum testosterone in females exposed to natural sour gas.	Testosterone	135-147	glutathione S-transferase theta 1	Homo sapiens	103-108
20300859-8	2011	Although GSTT1-null genotype had higher level of serum testosterone in comparison with the present genotype (t=2.392, df=66, P=0.023), a borderline difference between genotypes of GSTM1 for serum testosterone was observed (t=1.928, df=66, P=0.058).	Testosterone	55-67	glutathione S-transferase theta 1	Homo sapiens	9-14
20300859-8	2011	Although GSTT1-null genotype had higher level of serum testosterone in comparison with the present genotype (t=2.392, df=66, P=0.023), a borderline difference between genotypes of GSTM1 for serum testosterone was observed (t=1.928, df=66, P=0.058).	Testosterone	196-208	glutathione S-transferase theta 1	Homo sapiens	9-14
20300859-9	2011	Analysis of variance revealed significant difference between combination genotypes of GSTM1 and GSTT1 for serum testosterone (F=4.167; df=3, 64; P=0.009).	Testosterone	112-124	glutathione S-transferase theta 1	Homo sapiens	96-101
20300859-10	2011	The Duncan post hoc test indicated that the combination genotype of "present GSTM1/null GSTT1" had significant higher level of testosterone.	Testosterone	127-139	glutathione S-transferase theta 1	Homo sapiens	88-93
20300859-12	2011	The polymorphisms of GSTM1 and GSTT1 modulate serum testosterone concentration in young females exposed to natural sour gas.	Testosterone	52-64	glutathione S-transferase theta 1	Homo sapiens	31-36
21619788-6	2011	GSTT1 and GSTP1 were interacted on the urinary concentrations of 1-OHP.	Oxaliplatin	65-70	glutathione S-transferase theta 1	Homo sapiens	0-5
21619788-7	2011	CONCLUSION: Urinary 1-OHP concentrations can be modified by GSTM1, GSTT1 and GSTP1 gene polymorphisms, indicating that these genes are involved in the metabolism of polycyclic aromatic hydrocarbons.	Oxaliplatin	20-25	glutathione S-transferase theta 1	Homo sapiens	67-72
21619788-7	2011	CONCLUSION: Urinary 1-OHP concentrations can be modified by GSTM1, GSTT1 and GSTP1 gene polymorphisms, indicating that these genes are involved in the metabolism of polycyclic aromatic hydrocarbons.	Polycyclic Aromatic Hydrocarbons	165-197	glutathione S-transferase theta 1	Homo sapiens	67-72
21156236-0	2010	GSTT1 copy number gain is a poor predictive marker for escalated-dose imatinib treatment in chronic myeloid leukemia: genetic predictive marker found using array comparative genomic hybridization.	Imatinib Mesylate	70-78	glutathione S-transferase theta 1	Homo sapiens	0-5
20837120-0	2010	Susceptibility to the cytogenetic effects of dichloromethane is related to the glutathione S-transferase theta phenotype.	Methylene Chloride	45-60	glutathione S-transferase theta 1	Homo sapiens	79-110
20675267-7	2010	Among the 195 cases and 192 controls with high-risk forms of GSTT1 and GSTZ1, the ORs for quartiles 2, 3, and 4 of THMs were 1.5 (0.7-3.5), 3.4 (1.4-8.2), and 5.9 (1.8-19.0), respectively.	Trihalomethanes	115-119	glutathione S-transferase theta 1	Homo sapiens	61-66
20194072-0	2010	Interaction between GSTM1/GSTT1 polymorphism and blood mercury on birth weight.	Mercury	55-62	glutathione S-transferase theta 1	Homo sapiens	26-31
20042523-6	2010	The strongest inverse association was found among individuals with both the GSTM1-null and the GSTT1-null genotypes, with an adjusted odds ratio of 0.51 (95% CI: 0.27, 0.95), in a comparison of the highest with the lowest tertile of urinary isothiocyanates.	Isothiocyanates	241-256	glutathione S-transferase theta 1	Homo sapiens	95-100
20042523-8	2010	CONCLUSION: This study suggests that isothiocyanate exposure may reduce the risk of colorectal cancer, and this protective effect may be modified by the GSTM1 and GSTT1 genes.	isothiocyanic acid	37-51	glutathione S-transferase theta 1	Homo sapiens	163-168
20638463-3	2010	We conducted a study to determine whether N-Acetyl-cysteine (NAC) protected men against noise-induced temporary threshold shift (TTS), and whether subgroups with genetic polymorphisms of glutathione S-transferase (GST) T1 and M1 responded to NAC differently.	Acetylcysteine	242-245	glutathione S-transferase theta 1	Homo sapiens	187-228
20638463-11	2010	When the participants were grouped by GST M1/T1 genotypes, the NAC effect was only significant among workers with null genotypes in both GSTM1 and GSTT1 (p = 0.004).	Acetylcysteine	63-66	glutathione S-transferase theta 1	Homo sapiens	147-152
20638463-13	2010	The protective effect of NAC was more prominent in subjects with both GSTM1-null and GSTT1-null genotypes.	Acetylcysteine	25-28	glutathione S-transferase theta 1	Homo sapiens	85-90
20663906-7	2010	A significant association was found among TCE-exposed subjects with at least one intact GSTT1 allele (active genotype; OR = 1.88; 95% CI, 1.06-3.33) but not among subjects with two deleted alleles (null genotype; OR = 0.93; 95% CI, 0.35-2.44; P(interaction) = 0.18).	Trichloroethylene	42-45	glutathione S-transferase theta 1	Homo sapiens	88-93
19838709-5	2010	Patients who had null genotype for both the alleles, i.e., GSTT1/GSTM1 had significantly higher levels of serum iron (P = 0.007) and serum ferritin (P = 0.001) than patients with normal genotype for GST deletions.	Iron	112-116	glutathione S-transferase theta 1	Homo sapiens	59-64
20042523-5	2010	RESULTS: Urinary isothiocyanate concentrations were inversely associated with colorectal cancer risk; the inverse association was statistically significant or nearly significant in the GSTM1-null (P for trend = 0.04) and the GSTT1-null (P for trend = 0.07) genotype groups.	isothiocyanic acid	17-31	glutathione S-transferase theta 1	Homo sapiens	225-230
20200426-9	2010	Furthermore, GSTM4, GSTT1, and ABCC4 overexpression significantly decreased cisplatin sensitivity in lung cancer and HEK293T cell lines.	Cisplatin	76-85	glutathione S-transferase theta 1	Homo sapiens	20-25
20200426-11	2010	ABCC4 polymorphisms, as well as GSTT1 copy number, may also help to predict cisplatin response, but further validation is required.	Cisplatin	76-85	glutathione S-transferase theta 1	Homo sapiens	32-37
21637441-2	2009	We tested whether the null genotypes of the GSTM1 and GSTT1 genes, involved in benzene inactivation, altered the risk for NEB in southeastern Brazil.	Benzene	79-86	glutathione S-transferase theta 1	Homo sapiens	54-59
20056632-9	2010	Those with deletions in both GSTM1 and GSTT1 genes combined had a significantly reduced risk with increasing glucosinolate intake (P(interaction) = 0.01).	Glucosinolates	109-122	glutathione S-transferase theta 1	Homo sapiens	39-44
20056632-11	2010	This study showed that the inverse association between glucosinolate intake and prostate cancer risk was modified by NQO1 (C609T) and GSTM1 and GSTT1 deletion polymorphisms.	Glucosinolates	55-68	glutathione S-transferase theta 1	Homo sapiens	144-149
20464961-0	2010	[Association of genetic polymorphism in GSTM1 and GSTT1 with the frequency of chromosomal aberrations in the uranium workers].	Uranium	109-116	glutathione S-transferase theta 1	Homo sapiens	50-55
20464961-1	2010	Association between genetic polymorphism in GSTM1 and GSTT1 and frequency of chromosomal aberrations in the workers occupationally exposed to uranium during 1-25 years in Tselinniy mining/milling complex in the North Kazakhstan was investigated.	Uranium	142-149	glutathione S-transferase theta 1	Homo sapiens	54-59
19710200-6	2009	RESULTS: A gene-diet interaction on serum ascorbic acid was observed for GSTM1 (P = 0.04) and GSTT1 (P = 0.01) but not for GSTP1 (P = 0.83).	Ascorbic Acid	42-55	glutathione S-transferase theta 1	Homo sapiens	94-99
19741569-10	2009	Failure, after platinum-based chemotherapy, was associated with the GSTT1positive/GSTP-AA or GSTP-GG/GSTM1-positive genotype (P = 0.019, OR: 2.168, 95% CI: 1.130-4.160).	Platinum	15-23	glutathione S-transferase theta 1	Homo sapiens	68-73
19843381-4	2009	In this study, the expression of the wild and mutant type of the GSTT-1 gene of those stable transformants in cell lines and in bone marrow cells from MDS patients by reverse-transcription polymerase chain reaction (RT-PCR) was observed in the presence or absence of rapamycin.	Sirolimus	267-276	glutathione S-transferase theta 1	Homo sapiens	65-71
19843381-5	2009	Significant growth inhibition by rapamycin was observed among stable transformants for the mutant GSTT-1 gene, but not wild type GSTT-1 gene, and was indicative of typical apoptosis.	Sirolimus	33-42	glutathione S-transferase theta 1	Homo sapiens	98-104
19419718-7	2009	CONCLUSIONS: The data suggest that the presence of a double deletion genotypes of the GSTM1 and GSTT1 genes is associated with hypertriglyceridemia and low HDL-cholesterol levels in humans.	Cholesterol	160-171	glutathione S-transferase theta 1	Homo sapiens	96-101
18642130-0	2009	Serum levels of testosterone and gonadotrophins with respect to smoking status and genetic polymorphism of GSTT1.	Testosterone	16-28	glutathione S-transferase theta 1	Homo sapiens	107-112
19097986-4	2009	AZM exposure significantly decreased GSTT1 and GSTM1 mRNA and protein expression in IB3-1, restoring the levels to those observed in non-CF C38 cells, which also express lower levels of gamma-glutamyltransferase (GGT) activity than IB3-1.	Azithromycin	0-3	glutathione S-transferase theta 1	Homo sapiens	37-42
19097986-5	2009	In another CF cell line, 2CFSMEo-, AZM produced 45% reduction in GSTT1 and GSTM1 mRNA levels.	Azithromycin	35-38	glutathione S-transferase theta 1	Homo sapiens	65-70
19515364-11	2009	GSTP1-114/GSTT1 and GSTP1-105/GCLC combinations showed synergistic effects on hair mercury levels compared to single-gene variants.	Mercury	83-90	glutathione S-transferase theta 1	Homo sapiens	10-15
19548560-0	2009	[Influence of PAHs exposure and GSTT1, GSTM1 genotypes on urinary 1-OHP as exposure biomarker].	Oxaliplatin	66-71	glutathione S-transferase theta 1	Homo sapiens	32-37
19303595-6	2009	The risk of low motility with high DDE-DDT exposure was increased in men with the GSTT1 null genotype compared to those with GSTT1 intact (odds ratio (OR)=4.19, 95% confidence interval (CI) 1.05-16.78 and OR=3.57, 1.43-8.93, respectively).	Dichlorodiphenyl Dichloroethylene	35-38	glutathione S-transferase theta 1	Homo sapiens	82-87
19303595-10	2009	CONCLUSION: High DDE-DDT exposure adversely affected all 3 sperm parameters and its effects were exacerbated by the GSTT1 null polymorphism and by the CYP1A1 common alleles.	Dichlorodiphenyl Dichloroethylene	17-20	glutathione S-transferase theta 1	Homo sapiens	116-121
19927646-0	2009	[Abnormal liver function associated with polymorphism of GSTT1, GSTM1 and CYP2E1 in workers exposed to N, N-dimethylformamide].	Dimethylformamide	103-125	glutathione S-transferase theta 1	Homo sapiens	57-62
19927646-1	2009	OBJECTIVE: To investigate abnormal liver function associated with polymorphism of GSTT1, GSTM1 and CYP2E1 in workers exposed to N, N-dimethylformamide.	Dimethylformamide	128-150	glutathione S-transferase theta 1	Homo sapiens	82-87
19157724-1	2009	In a case-control study, association of polymorphism in glutathione-S-transferases (GSTM1, GSTT1, GSTP1), involved in detoxification of reactive oxygen species (ROS), was studied with alcoholic liver cirrhosis.	Reactive Oxygen Species	136-159	glutathione S-transferase theta 1	Homo sapiens	91-96
19548560-1	2009	OBJECTIVE: To study the influence of polycyclic aromatic hydrocarbons (PAHs) exposure (ambient concentration and smoking) and GSTT1, GSTM1, genotypes on urinary 1-OHP as exposure biomarker.	Oxaliplatin	161-166	glutathione S-transferase theta 1	Homo sapiens	126-131
19131562-7	2009	The ratio of GA-Hb/AA-Hb in individuals with the combined GSTM1- and GSTT1-null variants was significantly (p = 0.029) higher than those with the wild-type genotypes.	glycidamide	13-15	glutathione S-transferase theta 1	Homo sapiens	69-74
19388510-3	2009	The most widely studied group were genes encoded molecules engaged in biotransformations of xenobiotics, in particular potential carcinogens, like alcohol (ADH2) and aldehyde (ALDH2) dehydrogenases, various isoenzymes of cytochrome P450 (CYP1A1, CYP2E1) and glutathione S-transferase (GSTM1, GSTT1, GSTP1).	Alcohols	147-154	glutathione S-transferase theta 1	Homo sapiens	292-297
18449862-2	2009	In this study, we performed association studies between GSH-related genes (GSTM1, GSTP1, GSTO1, GSTT1, GSTT2, GPX1, and GCLM) and schizophrenia in a Japanese population.	Glutathione	56-59	glutathione S-transferase theta 1	Homo sapiens	96-101
18559562-13	2008	Using SPMA for evaluating benzene exposure, the results suggest that the GSTT1 genetic polymorphism, especially in a comparison study between two populations with different GSTT1 genotype frequencies, should be considered.	Benzene	26-33	glutathione S-transferase theta 1	Homo sapiens	73-78
17874314-1	2008	OBJECTIVE: In order to examine whether chronic exposure to natural sour gas containing sulfur compounds act as natural selection force on genetic polymorphisms of glutathione S-transferase M1 (GSTM1) and T1 (GSTT1), the present study was done.	Sulfur	87-93	glutathione S-transferase theta 1	Homo sapiens	208-213
18186040-4	2008	There was a significant difference in GSTT1 genotype frequency between patients with METH psychosis and controls (P = 0.039, odds ratio: 1.52, 95% CI 1.03-2.24).	Methamphetamine	85-89	glutathione S-transferase theta 1	Homo sapiens	38-43
18186040-5	2008	Furthermore, the frequency (66.0%) of the GSTT1 null genotype among prolonged-type METH psychotic patients with spontaneous relapse was significantly higher (P = 0.025, odds ratio: 2.43, 95% CI 1.13-5.23) than that (44.4%) of transient-type METH psychotic patients without spontaneous relapse.	Methamphetamine	83-87	glutathione S-transferase theta 1	Homo sapiens	42-47
18186040-5	2008	Furthermore, the frequency (66.0%) of the GSTT1 null genotype among prolonged-type METH psychotic patients with spontaneous relapse was significantly higher (P = 0.025, odds ratio: 2.43, 95% CI 1.13-5.23) than that (44.4%) of transient-type METH psychotic patients without spontaneous relapse.	Methamphetamine	241-245	glutathione S-transferase theta 1	Homo sapiens	42-47
18186040-7	2008	The present study suggests that the polymorphism of the GSTT1 gene might be a genetic risk factor of the development of METH psychosis in a Japanese population.	Methamphetamine	120-124	glutathione S-transferase theta 1	Homo sapiens	56-61
18577398-0	2008	CYP1A1 Ile462Val and GSTT1 modify the effect of cord blood cotinine on neurodevelopment at 2 years of age.	Cotinine	59-67	glutathione S-transferase theta 1	Homo sapiens	21-26
18577398-12	2008	It can be concluded that CYP1A1 Ile462Val and GSTT1 metabolic genes can modify the effect of cord blood cotinine on early child neurodevelopment especially for language and fine motor development.	Cotinine	104-112	glutathione S-transferase theta 1	Homo sapiens	46-51
19317600-1	2008	Cytochrome 1A1 (CYP1A1), glutathione transferase M1 (GSTM1), and glutathione transferase T1 (GSTT1) catalyze the bioactivation and detoxification of a wide variety of xenobiotic compounds that are mutagenic and/or carcinogenic (e.g., polycyclic aromatic hydrocarbons).	Polycyclic Aromatic Hydrocarbons	234-266	glutathione S-transferase theta 1	Homo sapiens	93-98
18641537-3	2008	In this report, the contribution of genetic polymorphisms in the glutathione-S-transferases (GST) isozymes GSTA1, GSTM1, GSTP1, and GSTT1 to the pharmacokinetics of busulfan is studied retrospectively.	Busulfan	165-173	glutathione S-transferase theta 1	Homo sapiens	132-137
18839526-0	2008	[Study on the relationship between GSTM1, GSTT1 gene polymorphisms and arsenic methylation level].	Arsenic	71-78	glutathione S-transferase theta 1	Homo sapiens	42-47
18839526-1	2008	OBJECTIVE: To investigate the relationship between genetic polymorphisms of GSTT1, GSTM1 and arsenic methylation level.	Arsenic	93-100	glutathione S-transferase theta 1	Homo sapiens	76-81
19252342-3	2009	In this study, to elucidate the haplotype structures of GSTT1 and GSTM1, genetic variations were identified in 194 Japanese cancer patients who received platinum-based chemotherapy.	Platinum	153-161	glutathione S-transferase theta 1	Homo sapiens	56-61
19057715-2	2008	We hypothesized that genetic variability in glutathione S-transferase (GST) genes (GSTP1, GSTM1, and GSTT1) could influence the effects of prenatal exposure to p,p"-DDT.	DDT	160-168	glutathione S-transferase theta 1	Homo sapiens	101-106
18594869-11	2008	Our results indicate that among children with steroid-sensitive NS, there is an association with response to IVCP therapy and combination of GSTP1 Val105 polymorphism and the null genotypes of GSTT1 and GSTM1.	Steroids	46-53	glutathione S-transferase theta 1	Homo sapiens	193-198
18608187-1	2008	The aim of this work was to investigate urinary analytes and haemoglobin and albumin adducts as biomarkers of exposure to airborne styrene (Sty) and styrene-(7,8)-oxide (StyOX) and to evaluate the influence of smoking habit and genetic polymorphism of metabolic enzymes GSTM1 and GSTT1 on these biomarkers.	styrene oxide	170-175	glutathione S-transferase theta 1	Homo sapiens	280-285
19103108-1	2008	OBJECTIVE: To study the potential effect of gene-environment interaction between glutathione S-transferase T1 (GSTT1) and serum organochlorines residues on the risk of breast cancer in women, in China.	Hydrocarbons, Chlorinated	128-143	glutathione S-transferase theta 1	Homo sapiens	81-109
19103108-6	2008	RESULTS: After adjusting the confounding factors, results showed that interaction existed in genetic polymorphisms of GSTT1 and dichlorodiphenyltrichloroethane (DDT)/hexachlorocyclohexane (HCH) residues, with interaction indexes (gamma) value as 1.352 and 1.528.	DDT	128-159	glutathione S-transferase theta 1	Homo sapiens	118-123
18559562-13	2008	Using SPMA for evaluating benzene exposure, the results suggest that the GSTT1 genetic polymorphism, especially in a comparison study between two populations with different GSTT1 genotype frequencies, should be considered.	Benzene	26-33	glutathione S-transferase theta 1	Homo sapiens	173-178
17953974-0	2008	Inherited susceptibility to bleomycin-induced micronuclei: correlating polymorphisms in GSTT1, GSTM1 and DNA repair genes with mutagen sensitivity.	Bleomycin	28-37	glutathione S-transferase theta 1	Homo sapiens	88-93
17880951-10	2008	The LH levels varied between the two groups; the mean serum LH was lower in the exposed versus unexposed men who possessed the GSTT1 genotype (2.82 +/- 1.32 IU/L vs. 3.20 +/- 1.17 IU/L) and higher in the exposed versus unexposed men who possessed the GSTT1-null genotype (3.52 +/- 1.37 IU/L vs. 2.76 +/- 1.07 IU/L).	Luteinizing Hormone	60-62	glutathione S-transferase theta 1	Homo sapiens	127-132
17912498-4	2008	Safrole may be metabolized by hepatic sulfotransferase 1A1 (SULT1A1), or glutathione S-transferases (GSTM1, GSTT1, and GSTP1).	Safrole	0-7	glutathione S-transferase theta 1	Homo sapiens	108-113
18325667-1	2008	In order to investigate the association between effects of genetic polymorphisms of GSTT1 and GSTM1 and depression score of individuals chronically exposed to natural sour gas containing sulfur compounds, the present cross-sectional study was done.	Sulfur	187-193	glutathione S-transferase theta 1	Homo sapiens	84-89
18155166-0	2008	Glutathione-S-transferase (GST) M1 null genotype and combined GSTM1 and GSTT1 null genotypes are risk factors for increased serum gamma-glutamyltransferase in valproic acid-treated patients.	Valproic Acid	159-172	glutathione S-transferase theta 1	Homo sapiens	72-77
18155166-7	2008	CONCLUSIONS: The GSTM1- and GSTM1-/GSTT1- genotypes may be a genetic risk factor for the increase of GGT in VPA-treated patients.	Valproic Acid	108-111	glutathione S-transferase theta 1	Homo sapiens	35-40
18303971-6	2008	Genetic variations in the glutathione S-transferases GSTT1 and GSTM1 have been studied in many human populations, and association of these variations with environmentally-related cancers, drug-induced hepatotoxicity and even chronification of viral hepatitis has been shown.	Glutathione	26-37	glutathione S-transferase theta 1	Homo sapiens	53-58
17975885-8	2007	GSTT1-1 hardly catalyzes the glutathione conjugation of curcumin.	Glutathione	29-40	glutathione S-transferase theta 1	Homo sapiens	0-7
18035380-1	2008	Polymorphism in glutathione S-transferase (GST) genes (GSTM1, GSTT1 and GSTP1) and interaction with environmental factors such as tobacco (smoking or chewing) and alcohol on susceptibility to head and neck squamous cell carcinoma (HNSCC) was studied in a case-control study.	Alcohols	163-170	glutathione S-transferase theta 1	Homo sapiens	43-46
17975885-8	2007	GSTT1-1 hardly catalyzes the glutathione conjugation of curcumin.	Curcumin	56-64	glutathione S-transferase theta 1	Homo sapiens	0-7
17513527-5	2007	METHODS: In the present study, the association between ARHI and polymorphisms in genes that contribute to the defence against reactive oxygen species, including GSTT1, GSTM1 and NAT2, was tested.	Reactive Oxygen Species	126-149	glutathione S-transferase theta 1	Homo sapiens	161-166
17980649-12	2007	A recent epidemiologic study found that much of the risk for bladder cancer associated with drinking water was associated with three factors: THM levels, showering/bathing/swimming (i.e., dermal/inhalation exposure), and genotype (having the GSTT1-1 gene).	Water	101-106	glutathione S-transferase theta 1	Homo sapiens	242-249
17716707-11	2007	RESULTS: The following was noted: a) hair mercury concentrations are significantly increased in persons with the double deleted genotype (GSTT1-/- and GSTM1-/-) as compared to persons with the intact genotype, and b) MT1X expression is higher in persons with the intact genotype (GSTT1+/+ and GSTM1+/+).	Mercury	42-49	glutathione S-transferase theta 1	Homo sapiens	138-143
17716707-11	2007	RESULTS: The following was noted: a) hair mercury concentrations are significantly increased in persons with the double deleted genotype (GSTT1-/- and GSTM1-/-) as compared to persons with the intact genotype, and b) MT1X expression is higher in persons with the intact genotype (GSTT1+/+ and GSTM1+/+).	Mercury	42-49	glutathione S-transferase theta 1	Homo sapiens	280-285
17716707-12	2007	CONCLUSIONS: We conclude that the epistatic effect of the GSTT1 and the GSTM1 deletion polymorphism is a risk factor for increased susceptibility to mercury exposure.	Mercury	149-156	glutathione S-transferase theta 1	Homo sapiens	58-63
17659824-2	2007	Cytochrome P450 2E1 (CYP2E1), aldehyde dehydrogenase 2 (ALDH2) and glutathione S-transferase theta 1 (GSTT1) enzymes are involved in activation and detoxification of VCM, and thus may be important determinants of interindividual susceptibility to VCM-induced liver damage, including liver cirrhosis.	Vinyl Chloride	166-169	glutathione S-transferase theta 1	Homo sapiens	67-100
17659824-2	2007	Cytochrome P450 2E1 (CYP2E1), aldehyde dehydrogenase 2 (ALDH2) and glutathione S-transferase theta 1 (GSTT1) enzymes are involved in activation and detoxification of VCM, and thus may be important determinants of interindividual susceptibility to VCM-induced liver damage, including liver cirrhosis.	Vinyl Chloride	166-169	glutathione S-transferase theta 1	Homo sapiens	102-107
17307802-1	2007	To test the hypothesis of interaction among genetic variants in increasing the individual risk of cancer, we have studied the cumulative effect on lung cancer risk of variants in three metabolic genes, CYP1A1, GSTM1 and GSTT1, which are involved in the metabolism of the tobacco smoke constituents and environmental contaminants, polycyclic aromatic hydrocarbons and of other lung carcinogens.	Polycyclic Aromatic Hydrocarbons	330-362	glutathione S-transferase theta 1	Homo sapiens	220-225
17706336-0	2007	GSTM1 and GSTT1 polymorphism influences protection against induced oxidative DNA damage by quercetin and ascorbic acid in human lymphocytes in vitro.	Quercetin	91-100	glutathione S-transferase theta 1	Homo sapiens	10-15
17706336-0	2007	GSTM1 and GSTT1 polymorphism influences protection against induced oxidative DNA damage by quercetin and ascorbic acid in human lymphocytes in vitro.	Ascorbic Acid	105-118	glutathione S-transferase theta 1	Homo sapiens	10-15
17706336-2	2007	This study aims to establish the impact of genetic polymorphisms in GSTM1 and GSTT1, which encode for enzymatic antioxidative defence, on H(2)O(2)-induced oxidative DNA damage and on the effectiveness of quercetin and ascorbic acid in preventing this induced damage in human lymphocytes.	Quercetin	204-213	glutathione S-transferase theta 1	Homo sapiens	78-83
17706336-2	2007	This study aims to establish the impact of genetic polymorphisms in GSTM1 and GSTT1, which encode for enzymatic antioxidative defence, on H(2)O(2)-induced oxidative DNA damage and on the effectiveness of quercetin and ascorbic acid in preventing this induced damage in human lymphocytes.	Ascorbic Acid	218-231	glutathione S-transferase theta 1	Homo sapiens	78-83
17706336-8	2007	The protection against H(2)O(2)-induced oxidative DNA damage by quercetin was significantly higher in GSTT1 wild types than in GSTT1 variants (57% and 9% decrease, respectively; p=0.01); furthermore, GSTT1 wild types were protected against induced oxidative DNA damage by ascorbic acid pre-incubation while GSTT1 variants showed an increase of damage (16% decrease vs. 91% increase; p=0.01).	Hydrogen Peroxide	23-31	glutathione S-transferase theta 1	Homo sapiens	102-107
17706336-8	2007	The protection against H(2)O(2)-induced oxidative DNA damage by quercetin was significantly higher in GSTT1 wild types than in GSTT1 variants (57% and 9% decrease, respectively; p=0.01); furthermore, GSTT1 wild types were protected against induced oxidative DNA damage by ascorbic acid pre-incubation while GSTT1 variants showed an increase of damage (16% decrease vs. 91% increase; p=0.01).	Hydrogen Peroxide	23-31	glutathione S-transferase theta 1	Homo sapiens	127-132
17706336-8	2007	The protection against H(2)O(2)-induced oxidative DNA damage by quercetin was significantly higher in GSTT1 wild types than in GSTT1 variants (57% and 9% decrease, respectively; p=0.01); furthermore, GSTT1 wild types were protected against induced oxidative DNA damage by ascorbic acid pre-incubation while GSTT1 variants showed an increase of damage (16% decrease vs. 91% increase; p=0.01).	Hydrogen Peroxide	23-31	glutathione S-transferase theta 1	Homo sapiens	127-132
17706336-8	2007	The protection against H(2)O(2)-induced oxidative DNA damage by quercetin was significantly higher in GSTT1 wild types than in GSTT1 variants (57% and 9% decrease, respectively; p=0.01); furthermore, GSTT1 wild types were protected against induced oxidative DNA damage by ascorbic acid pre-incubation while GSTT1 variants showed an increase of damage (16% decrease vs. 91% increase; p=0.01).	Hydrogen Peroxide	23-31	glutathione S-transferase theta 1	Homo sapiens	127-132
17706336-8	2007	The protection against H(2)O(2)-induced oxidative DNA damage by quercetin was significantly higher in GSTT1 wild types than in GSTT1 variants (57% and 9% decrease, respectively; p=0.01); furthermore, GSTT1 wild types were protected against induced oxidative DNA damage by ascorbic acid pre-incubation while GSTT1 variants showed an increase of damage (16% decrease vs. 91% increase; p=0.01).	Quercetin	64-73	glutathione S-transferase theta 1	Homo sapiens	102-107
17706336-8	2007	The protection against H(2)O(2)-induced oxidative DNA damage by quercetin was significantly higher in GSTT1 wild types than in GSTT1 variants (57% and 9% decrease, respectively; p=0.01); furthermore, GSTT1 wild types were protected against induced oxidative DNA damage by ascorbic acid pre-incubation while GSTT1 variants showed an increase of damage (16% decrease vs. 91% increase; p=0.01).	Quercetin	64-73	glutathione S-transferase theta 1	Homo sapiens	127-132
17706336-8	2007	The protection against H(2)O(2)-induced oxidative DNA damage by quercetin was significantly higher in GSTT1 wild types than in GSTT1 variants (57% and 9% decrease, respectively; p=0.01); furthermore, GSTT1 wild types were protected against induced oxidative DNA damage by ascorbic acid pre-incubation while GSTT1 variants showed an increase of damage (16% decrease vs. 91% increase; p=0.01).	Quercetin	64-73	glutathione S-transferase theta 1	Homo sapiens	127-132
17706336-8	2007	The protection against H(2)O(2)-induced oxidative DNA damage by quercetin was significantly higher in GSTT1 wild types than in GSTT1 variants (57% and 9% decrease, respectively; p=0.01); furthermore, GSTT1 wild types were protected against induced oxidative DNA damage by ascorbic acid pre-incubation while GSTT1 variants showed an increase of damage (16% decrease vs. 91% increase; p=0.01).	Quercetin	64-73	glutathione S-transferase theta 1	Homo sapiens	127-132
17706336-8	2007	The protection against H(2)O(2)-induced oxidative DNA damage by quercetin was significantly higher in GSTT1 wild types than in GSTT1 variants (57% and 9% decrease, respectively; p=0.01); furthermore, GSTT1 wild types were protected against induced oxidative DNA damage by ascorbic acid pre-incubation while GSTT1 variants showed an increase of damage (16% decrease vs. 91% increase; p=0.01).	Ascorbic Acid	272-285	glutathione S-transferase theta 1	Homo sapiens	102-107
17885617-7	2007	Results generally support prior associations between benzene hematotoxicity and specific gene mutations, confirm earlier evidence that GSTT1 affects production of S-phenylmercapturic acid, and provide additional evidence that genetic polymorphisms in NQO1*2, CYP2E1, and EPHX1 (rs1051740 or rs2234922) affect metabolism of benzene in the human liver.	S-phenyl-N-acetylcysteine	163-187	glutathione S-transferase theta 1	Homo sapiens	135-140
17445838-9	2007	Furthermore the significant inverse correlation between 8-oxodG and B[a]P DNA adducts was confined to individuals carrying the wild type genotype for both the GSTM1 and the GSTT1 gene (separately and interacting).	8-ohdg	56-63	glutathione S-transferase theta 1	Homo sapiens	173-178
17498780-6	2007	GSTT1 present carriers had a significantly higher urinary 1-OHP level than that in null carriers in the case with AhR R554K GA/AA carriers (5.17 vs. 3.64 micromol/mol creatinine, p=0.038), as well as in the case with UGT1A1 -3263T&gt;G TG/GG carriers (5.67 vs. 3.38 micromol/mol creatinine, p=0.001).	Oxaliplatin	58-63	glutathione S-transferase theta 1	Homo sapiens	0-5
17498780-6	2007	GSTT1 present carriers had a significantly higher urinary 1-OHP level than that in null carriers in the case with AhR R554K GA/AA carriers (5.17 vs. 3.64 micromol/mol creatinine, p=0.038), as well as in the case with UGT1A1 -3263T&gt;G TG/GG carriers (5.67 vs. 3.38 micromol/mol creatinine, p=0.001).	Creatinine	167-177	glutathione S-transferase theta 1	Homo sapiens	0-5
17498780-6	2007	GSTT1 present carriers had a significantly higher urinary 1-OHP level than that in null carriers in the case with AhR R554K GA/AA carriers (5.17 vs. 3.64 micromol/mol creatinine, p=0.038), as well as in the case with UGT1A1 -3263T&gt;G TG/GG carriers (5.67 vs. 3.38 micromol/mol creatinine, p=0.001).	Thioguanine	236-238	glutathione S-transferase theta 1	Homo sapiens	0-5
17498780-6	2007	GSTT1 present carriers had a significantly higher urinary 1-OHP level than that in null carriers in the case with AhR R554K GA/AA carriers (5.17 vs. 3.64 micromol/mol creatinine, p=0.038), as well as in the case with UGT1A1 -3263T&gt;G TG/GG carriers (5.67 vs. 3.38 micromol/mol creatinine, p=0.001).	Creatinine	279-289	glutathione S-transferase theta 1	Homo sapiens	0-5
17498780-7	2007	These results showed that AhR, UGT1A1, GSTP1 and GSTT1 polymorphisms were associated with urinary 1-OHP concentrations in Chinese coke oven workers.	Oxaliplatin	98-103	glutathione S-transferase theta 1	Homo sapiens	49-54
17310693-9	2007	Bladder cancer risk from THM exposure (all routes combined) was greatest among those with the GSTT1-1 gene.	Trihalomethanes	25-28	glutathione S-transferase theta 1	Homo sapiens	94-101
17450230-9	2007	We also saw minor effects of other polymorphisms in the multivariate regression analysis with effect modification for the deletion genotypes for GSTM1 (affecting %MMA) and GSTT1 (affecting %MMA and %DMA).	dma	199-202	glutathione S-transferase theta 1	Homo sapiens	172-177
17431481-7	2007	We observed significant interaction on the multiplicative scale between GSTT1 wildtype and secondary methylation ratio [dimethylarsinic acid/MMA; likelihood ratio test (LRT), p = 0.01].	Cacodylic Acid	120-140	glutathione S-transferase theta 1	Homo sapiens	72-77
17431481-7	2007	We observed significant interaction on the multiplicative scale between GSTT1 wildtype and secondary methylation ratio [dimethylarsinic acid/MMA; likelihood ratio test (LRT), p = 0.01].	monomethylarsonic acid	141-144	glutathione S-transferase theta 1	Homo sapiens	72-77
17431481-10	2007	The interaction between GSTT1 wildtype and secondary methylation ratio modifies risk of skin lesions among arsenic-exposed individuals.	Arsenic	107-114	glutathione S-transferase theta 1	Homo sapiens	24-29
17330842-0	2007	Role of GSTT1 deletion in DNA oxidative damage by exposure to polycyclic aromatic hydrocarbons in humans.	Polycyclic Aromatic Hydrocarbons	62-94	glutathione S-transferase theta 1	Homo sapiens	8-13
17330842-3	2007	The GSTT1 homozygous deletion variant was associated with a significant protective effect for exposure to total PAHs and to eight specific PAHs, although the magnitude and significance of the effect varied among these compounds.	Polycyclic Aromatic Hydrocarbons	112-116	glutathione S-transferase theta 1	Homo sapiens	4-9
17330842-3	2007	The GSTT1 homozygous deletion variant was associated with a significant protective effect for exposure to total PAHs and to eight specific PAHs, although the magnitude and significance of the effect varied among these compounds.	Polycyclic Aromatic Hydrocarbons	139-143	glutathione S-transferase theta 1	Homo sapiens	4-9
17330842-4	2007	Categorical sensitivity analysis was used to determine that the frequency of the GSTT1 deletion was significantly higher in people who proved to be more resistant to the DNA damaging effects of PAH exposure than in people who were the most sensitive.	Polycyclic Aromatic Hydrocarbons	194-197	glutathione S-transferase theta 1	Homo sapiens	81-86
17330842-6	2007	The mechanism for this effect might be related to specific PAH substrate specificities, or could be related to other functions of GSTT1 gene in oxidative stress induced damage pathways.	Polycyclic Aromatic Hydrocarbons	59-62	glutathione S-transferase theta 1	Homo sapiens	130-135
17465707-1	2007	UNLABELLED: The aim of this study is to verify whether the combination of glutathione S-transferase (GST) M1 null and GSTT1 null genotypes, which is a candidate genetic risk factor for troglitazone-induced liver failure, is common to that for the carbamazepine-induced mild hepatotoxicity.	Troglitazone	185-197	glutathione S-transferase theta 1	Homo sapiens	118-123
17465707-1	2007	UNLABELLED: The aim of this study is to verify whether the combination of glutathione S-transferase (GST) M1 null and GSTT1 null genotypes, which is a candidate genetic risk factor for troglitazone-induced liver failure, is common to that for the carbamazepine-induced mild hepatotoxicity.	Carbamazepine	247-260	glutathione S-transferase theta 1	Homo sapiens	118-123
17339179-10	2007	and del{GSTT1} polymorphisms showed a higher risk than females of developing AL.	Aluminum	77-79	glutathione S-transferase theta 1	Homo sapiens	8-13
17182005-1	2007	The aim of this study is to investigate GSTM1, GSTT1 and MTHFR genetic polymorphisms and its relation with total plasma glutathione (tGSH) levels in hypertension.	Glutathione	120-131	glutathione S-transferase theta 1	Homo sapiens	47-52
16406813-8	2007	CONCLUSION: Our study shows that exposure to urban traffic, dietary habits, and the nonnull GSTT1 genotype may contribute to interindividual variation in background levels of 1-OHP urinary excretion in subjects without occupational exposure to PAHs.	Oxaliplatin	175-180	glutathione S-transferase theta 1	Homo sapiens	92-97
16406813-8	2007	CONCLUSION: Our study shows that exposure to urban traffic, dietary habits, and the nonnull GSTT1 genotype may contribute to interindividual variation in background levels of 1-OHP urinary excretion in subjects without occupational exposure to PAHs.	Polycyclic Aromatic Hydrocarbons	244-248	glutathione S-transferase theta 1	Homo sapiens	92-97
17119257-8	2006	Variation in multiple benzene metabolizing genes may be associated with risk of benzene hematotoxicity, including CYP2E1, MPO, NQO1, and GSTT1.	Benzene	22-29	glutathione S-transferase theta 1	Homo sapiens	137-142
18333132-9	2007	RESULTS: Statistical analysis of the microarray data showed that four genes were differentially expressed in gemcitabine-sensitive cancers: microsomal glutathione S-transferase 1 (GSTT1), topoisomerase II alpha (TOP2A), caspase 3, and ATP-binding cassette and subfamily C member 2 (ABCC2).	gemcitabine	109-120	glutathione S-transferase theta 1	Homo sapiens	180-185
17078101-4	2006	Analysis of the effect of pairs of genes showed that for a fixed GSTT1 genotype, the SCE level increased with an increasing number of Tyr alleles in EPHX codon 113.	Tyrosine	134-137	glutathione S-transferase theta 1	Homo sapiens	65-70
17078101-5	2006	We found that among GSTT1(+) individuals the DEB-induced SCE level was significantly lower when the EPHX 139 codon was His/Arg rather than His/His.	Histidine	119-122	glutathione S-transferase theta 1	Homo sapiens	20-25
17078101-5	2006	We found that among GSTT1(+) individuals the DEB-induced SCE level was significantly lower when the EPHX 139 codon was His/Arg rather than His/His.	Arginine	123-126	glutathione S-transferase theta 1	Homo sapiens	20-25
17078101-5	2006	We found that among GSTT1(+) individuals the DEB-induced SCE level was significantly lower when the EPHX 139 codon was His/Arg rather than His/His.	Histidine	139-142	glutathione S-transferase theta 1	Homo sapiens	20-25
17078101-5	2006	We found that among GSTT1(+) individuals the DEB-induced SCE level was significantly lower when the EPHX 139 codon was His/Arg rather than His/His.	Histidine	139-142	glutathione S-transferase theta 1	Homo sapiens	20-25
17011574-2	2006	For example, the human theta 1-1 enzyme (hGSTT1-1) is 440-fold less efficient than the rat theta 2-2 enzyme (rGSTT2-2) with the fluorogenic substrate 7-amino-4-chloromethyl coumarin (CMAC).	7-amino-4-chloromethylcoumarin	150-181	glutathione S-transferase theta 1	Homo sapiens	41-49
17011574-2	2006	For example, the human theta 1-1 enzyme (hGSTT1-1) is 440-fold less efficient than the rat theta 2-2 enzyme (rGSTT2-2) with the fluorogenic substrate 7-amino-4-chloromethyl coumarin (CMAC).	7-amino-4-chloromethylcoumarin	183-187	glutathione S-transferase theta 1	Homo sapiens	41-49
17011574-3	2006	Large libraries of hGSTT1-1 constructed by error-prone PCR, DNA shuffling, or saturation mutagenesis were screened for improved catalytic activity towards CMAC in a quantitative fashion using flow cytometry.	7-amino-4-chloromethylcoumarin	155-159	glutathione S-transferase theta 1	Homo sapiens	19-27
16874663-3	2006	Typical substrates for GSTT1 are industrial compounds, such as dichloromethane and ethylene oxide.	Methylene Chloride	63-78	glutathione S-transferase theta 1	Homo sapiens	23-28
16874663-3	2006	Typical substrates for GSTT1 are industrial compounds, such as dichloromethane and ethylene oxide.	Ethylene Oxide	83-97	glutathione S-transferase theta 1	Homo sapiens	23-28
16874663-4	2006	It has been shown that also chemotherapeutic drugs such as BCNU [i.e. 1,3-bis(2-chloroethyl)-1-nitrosourea] are efficiently inactivated by GSTT1.	Carmustine	59-63	glutathione S-transferase theta 1	Homo sapiens	139-144
16874663-4	2006	It has been shown that also chemotherapeutic drugs such as BCNU [i.e. 1,3-bis(2-chloroethyl)-1-nitrosourea] are efficiently inactivated by GSTT1.	Carmustine	70-106	glutathione S-transferase theta 1	Homo sapiens	139-144
17119257-8	2006	Variation in multiple benzene metabolizing genes may be associated with risk of benzene hematotoxicity, including CYP2E1, MPO, NQO1, and GSTT1.	Benzene	80-87	glutathione S-transferase theta 1	Homo sapiens	137-142
16918316-3	2006	GSTT1-1 is highly conserved during evolution and plays a major role in phase-II biotransformation of a number of drugs and industrial chemicals, e.g. cytostatic drugs, hydrocarbons and halogenated hydrocarbons.	Hydrocarbons	168-180	glutathione S-transferase theta 1	Homo sapiens	0-7
16938565-0	2006	Relation of glutathione S-transferase genotypes (GSTM1 and GSTT1) to laryngeal squamous cell carcinoma risk.	Glutathione	12-23	glutathione S-transferase theta 1	Homo sapiens	59-64
16865249-0	2006	Potential application of GSTT1-null genotype in predicting toxicity associated to 5-fluouracil irinotecan and leucovorin regimen in advanced stage colorectal cancer patients.	5-fluouracil irinotecan	82-105	glutathione S-transferase theta 1	Homo sapiens	25-30
16865249-0	2006	Potential application of GSTT1-null genotype in predicting toxicity associated to 5-fluouracil irinotecan and leucovorin regimen in advanced stage colorectal cancer patients.	Leucovorin	110-120	glutathione S-transferase theta 1	Homo sapiens	25-30
16865249-8	2006	Our data suggest that GSTT1-null is associated with a greater probability of developing toxicity to 5-Fu/CPT-11/Lv treatments, indicating a potential application of this genetic analysis in predicting adverse effects of this regimen.	Fluorouracil	100-104	glutathione S-transferase theta 1	Homo sapiens	22-27
16865249-8	2006	Our data suggest that GSTT1-null is associated with a greater probability of developing toxicity to 5-Fu/CPT-11/Lv treatments, indicating a potential application of this genetic analysis in predicting adverse effects of this regimen.	Irinotecan	105-111	glutathione S-transferase theta 1	Homo sapiens	22-27
16865249-8	2006	Our data suggest that GSTT1-null is associated with a greater probability of developing toxicity to 5-Fu/CPT-11/Lv treatments, indicating a potential application of this genetic analysis in predicting adverse effects of this regimen.	Leucovorin	112-114	glutathione S-transferase theta 1	Homo sapiens	22-27
16918316-3	2006	GSTT1-1 is highly conserved during evolution and plays a major role in phase-II biotransformation of a number of drugs and industrial chemicals, e.g. cytostatic drugs, hydrocarbons and halogenated hydrocarbons.	Hydrocarbons	197-209	glutathione S-transferase theta 1	Homo sapiens	0-7
16847185-13	2006	CONCLUSIONS: Our results suggest that the simultaneous presence of the GSTM1- and GSTT1-null genotypes is a susceptibility factor for DTC.	dtc	134-137	glutathione S-transferase theta 1	Homo sapiens	82-87
16918316-5	2006	Several lines of evidence suggest that hGSTT1-1 and/or hGSTM1-1 play a role in the deactivation of reactive oxygen species that are likely to be involved in cellular processes of inflammation, ageing and degenerative diseases.	Reactive Oxygen Species	99-122	glutathione S-transferase theta 1	Homo sapiens	39-47
16763966-0	2006	Nicotine metabolizing genes GSTT1 and CYP1A1 in sudden infant death syndrome.	Nicotine	0-8	glutathione S-transferase theta 1	Homo sapiens	28-33
16898590-1	2006	In this study, we have investigated correlation between enzymatic activity of NAD(P)-dependent dehydrogenases of lymphocytes and polymorphic variants of glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) genes in the group of unrelated patients with acute pancreatitis in comparison with healthy Russians from Krasnoyarsk.	NADP	78-84	glutathione S-transferase theta 1	Homo sapiens	198-203
16998606-3	2006	In our study we analysed the distribution of single and combined CYP1A1, GSTM1, GSTT1 and GSTP1 genotypes contributing to inter-individual differences in metabolism of xenobiotics and ROS in 125 Slovenian healthy individuals and in 140 patients with sporadic malignant melanoma.	Reactive Oxygen Species	184-187	glutathione S-transferase theta 1	Homo sapiens	80-85
16424821-5	2006	The possible influence of genetic polymorphisms of xenobiotic-metabolizing enzymes involved in styrene biotransformation (EPHX1, GSTT1, GSTM1, GSTP1) and NAT2 on the cytogenetic endpoints was investigated.	Styrene	95-102	glutathione S-transferase theta 1	Homo sapiens	129-134
16753877-4	2006	In this study, the expression of wild and mutant type GSTT-1 gene of those stable transformants and bone marrow cells from MDS patients by RT-PCR was observed in the presence or absence of rapamycin.	Sirolimus	189-198	glutathione S-transferase theta 1	Homo sapiens	54-60
16624155-5	2006	The risk of failure to achieve CR in patients with GSTT1 null/GSTM1 null is 8.736 times higher than that in patients with GSTT1 and GSTM1 genes double-present (odds ratio OR was 8.736, 95% CI was 1.146 - 66.574).	Chromium	31-33	glutathione S-transferase theta 1	Homo sapiens	51-56
16424821-12	2006	Our results suggest that occupational exposure to styrene has genotoxic effects that are potentiated by the GSTT1 gene deletion.	Styrene	50-57	glutathione S-transferase theta 1	Homo sapiens	108-113
16125881-4	2005	The subjects" genetic polymorphisms in the genes that encode the styrene-metabolizing enzymes CYP2E1, CYP2B6, EPHX1, GSTM1, GSTT1 and GSTP1 were determined.	Styrene	65-72	glutathione S-transferase theta 1	Homo sapiens	124-129