PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 32583831-8 2020 The addition of UL iron to the diet significantly reduced the expression of tight junction proteins Claudin-1, Occludin, and ZO-1 in the duodenal mucosa of weaned piglets (P < 0.05). Iron 19-23 zonula occludens 1 Sus scrofa 125-129 33847777-7 2021 Immunofluorescence analysis also shows that the decreased membrane presence of claudin-4 and ZO-1 induced by DON is reversible with dynamin inhibition, whereas the pretreatment with cytochalasin D (an actin-dependent endocytosis inhibitor) reverses the degradation of claudin-1 and 4 induced by DON. deoxynivalenol 109-112 zonula occludens 1 Sus scrofa 93-97 33847777-7 2021 Immunofluorescence analysis also shows that the decreased membrane presence of claudin-4 and ZO-1 induced by DON is reversible with dynamin inhibition, whereas the pretreatment with cytochalasin D (an actin-dependent endocytosis inhibitor) reverses the degradation of claudin-1 and 4 induced by DON. deoxynivalenol 295-298 zonula occludens 1 Sus scrofa 93-97 33847777-9 2021 Resveratrol, with JNK inhibitory activity, also prevents the endocytosis and degradation of claudin-4 and ZO-1 and protects against DON-induced decrease in transepithelial electrical resistance (TEER) and increase in FITC-dextran permeability. Resveratrol 0-11 zonula occludens 1 Sus scrofa 106-110 33932823-8 2021 In addition, Gln and Ala-Gln upregulated intestinal barrier associated gene expressions including pBD-1, pBD-2, MUC-2, ZO-1, occludin and claudin-3. Glutamine 13-16 zonula occludens 1 Sus scrofa 119-123 33932823-8 2021 In addition, Gln and Ala-Gln upregulated intestinal barrier associated gene expressions including pBD-1, pBD-2, MUC-2, ZO-1, occludin and claudin-3. alanylglutamine 21-28 zonula occludens 1 Sus scrofa 119-123 33150307-17 2020 Messenger ribonucleic acid abundance of occludin and zonula-occludens-1 in ileal tissue was increased by ESBM1 or ESBM2 (P < 0.05). ribonucleic 10-21 zonula occludens 1 Sus scrofa 53-71 32487741-14 2020 Using the cannulated pig model, we found that the distinct C/N ratio induced by cecal infusion of corn starch or casein hydrolysate was linearly correlated with microbial metabolites (secondary bile acids) and tight junction proteins (ZO-1 and OCLD). Nitrogen 61-62 zonula occludens 1 Sus scrofa 235-239 32884745-10 2020 Meanwhile, dietary 1.0% TA supplementation tended to up-regulate OCLN mRNA levels in the jejunum (P < 0.10) and 0.2% TA supplementation tended to up-regulate zonula occludens-1 (ZO-1) mRNA levels in the ileum (P < 0.10). Tannins 117-119 zonula occludens 1 Sus scrofa 158-176 32884745-10 2020 Meanwhile, dietary 1.0% TA supplementation tended to up-regulate OCLN mRNA levels in the jejunum (P < 0.10) and 0.2% TA supplementation tended to up-regulate zonula occludens-1 (ZO-1) mRNA levels in the ileum (P < 0.10). Tannins 117-119 zonula occludens 1 Sus scrofa 178-182 32735667-4 2020 The results showed that eugenol pretreatment significantly suppressed the LPS-stimulated interleukin-8 level and the mRNA abundance of tumor necrosis factor-alpha and restored the LPS-stimulated decrease of the mRNA abundance of tight junction proteins, such as ZO-1 and occludin, and the mRNA abundance of nutrient transporters, such as B0 1 system ASC sodium-dependent neutral amino acid exchanger 2, sodium-dependent glucose transporter 1, excitatory amino acid transporter 1, and peptide transporter 1. Eugenol 24-31 zonula occludens 1 Sus scrofa 262-266 32735667-5 2020 In addition, eugenol improved the expression and even redistribution of ZO-1 and tended to increase TEER value and maintained the barrier integrity. Eugenol 13-20 zonula occludens 1 Sus scrofa 72-76 32487741-8 2020 The ratio of C/N was linearly related with the concentrations of DCA and LCA and gene expression levels of ZO-1, occludin, and EGFR. Nitrogen 15-16 zonula occludens 1 Sus scrofa 107-111 31167787-7 2019 We demonstrate the utility of this probe by sequencing the protein-protein interaction regions between the Hippo pathway protein Yes-associated protein 2 (YAP2) and tight junction protein 1 (TJP1 or ZO-1), uncovering interactions via the known binding domain as well as ZO-1"s MAGUK domain and YAP"s N-terminal proline-rich domain. Proline 311-318 zonula occludens 1 Sus scrofa 199-203 32374314-9 2020 Interestingly, CON and high amylose groups enhanced the localization of ZO-1 protein in apical intercellular region of jejunal epithelium. Amylose 28-35 zonula occludens 1 Sus scrofa 72-76 31637977-5 2019 Compared with the HS group, SS and SeMet supplementation resulted in an increase (P < 0 05) in cell viability, decreased (P < 0 05) mRNA expression of HSP70 and six inflammation-related genes and rescue (P < 0 05) of mRNA and protein levels of CLDN-1 and ZO-1. Sodium Selenite 28-30 zonula occludens 1 Sus scrofa 264-268 31637977-5 2019 Compared with the HS group, SS and SeMet supplementation resulted in an increase (P < 0 05) in cell viability, decreased (P < 0 05) mRNA expression of HSP70 and six inflammation-related genes and rescue (P < 0 05) of mRNA and protein levels of CLDN-1 and ZO-1. Selenomethionine 35-40 zonula occludens 1 Sus scrofa 264-268 31245003-13 2019 H2 diet up-regulated the expression of ZO-1 compared with control group (P < 0.05). Hydrogen 0-2 zonula occludens 1 Sus scrofa 39-43 30349690-14 2018 Furthermore, it was also found that GOS enhanced the protein expression of ZO-1 and occludin on d 8 (P < 0.05), as well as increased the mRNA expression of TGF-beta and decrease the mRNA expression of IL-12 (P < 0.05). D-Glucitol-1,6-bisphosphate 36-39 zonula occludens 1 Sus scrofa 75-99 30747184-11 2019 Mechanistically, different concentrations of Vitamin A (0-20 mumol L-1) enhanced tight junction protein markers including Zo-1, Occludin and Claudin-1 both at protein and mRNA levels with an optimized dose of 0.1 mumol L-1. Vitamin A 45-54 zonula occludens 1 Sus scrofa 122-126 30599507-6 2019 Tributyrin reduced ( P < 0.05) serum diamine oxidase activity and d-lactate content, increased ( P < 0.05) transepithelial electrical resistance, decreased paracellular flux of dextran (4 kDa), and prevented the diquat-induced decrease ( P < 0.05) in the expressions of claudin-1, occludin, and zonula occludens-1. tributyrin 0-10 zonula occludens 1 Sus scrofa 304-322 27314026-5 2016 The OEO-treated pigs showed decreased (P < 0.05) endotoxin level in serum and increased (P < 0.05) villus height and expression of occludin and zonula occludens-1 (ZO-1) in the jejunum. oeo 4-7 zonula occludens 1 Sus scrofa 150-168 29184078-6 2017 The permeability of FD-4 and expression of ZO-1 and OCLN in cyclophosphamide-treated IPEC-J2 cells were reduced by capric acid. Cyclophosphamide 60-76 zonula occludens 1 Sus scrofa 43-47 29184078-6 2017 The permeability of FD-4 and expression of ZO-1 and OCLN in cyclophosphamide-treated IPEC-J2 cells were reduced by capric acid. decanoic acid 115-126 zonula occludens 1 Sus scrofa 43-47 28125771-5 2017 The trial period is 60 d. Compared with control group, the mRNA abundance of claudin-3 and zonula occluden-1 (ZO-1) in the jejunum in 0.2% Trp group (P < 0.05) was increased. Tryptophan 139-142 zonula occludens 1 Sus scrofa 91-108 28125771-5 2017 The trial period is 60 d. Compared with control group, the mRNA abundance of claudin-3 and zonula occluden-1 (ZO-1) in the jejunum in 0.2% Trp group (P < 0.05) was increased. Tryptophan 139-142 zonula occludens 1 Sus scrofa 110-114 28125771-6 2017 According to immunohistochemistry and immunoblotting test, the expression of ZO-1 in jejunum in 0.2% Trp group was also significantly increased compared with the control group (P < 0.05). Tryptophan 101-104 zonula occludens 1 Sus scrofa 77-81 28125771-7 2017 These results revealed that Trp enhanced the expression of tight junction protein ZO-1 in the intestine of pig model. Tryptophan 28-31 zonula occludens 1 Sus scrofa 82-86 26954146-6 2016 In normal cells, both wortmannin and LY294002, PI3K inhibitors, prevented the mRNA and protein expressions of Akt and mTOR increase induced by GLP-2 (p<0.01) following with the significant decreasing of occludin, claudin-1, ZO-1 mRNA and proteins expressions and TER (p<0.01). Wortmannin 22-32 zonula occludens 1 Sus scrofa 227-231 26954146-6 2016 In normal cells, both wortmannin and LY294002, PI3K inhibitors, prevented the mRNA and protein expressions of Akt and mTOR increase induced by GLP-2 (p<0.01) following with the significant decreasing of occludin, claudin-1, ZO-1 mRNA and proteins expressions and TER (p<0.01). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 37-45 zonula occludens 1 Sus scrofa 227-231 25050009-6 2014 U0126, an MAPK kinase inhibitor, prevented the mRNA and protein expressions of ZO-1, occludin, claudin-1 increase induced by GLP-2 (p<0.05). U 0126 0-5 zonula occludens 1 Sus scrofa 79-83 25878205-9 2015 L-Trp also upregulated (P < 0.05) the abundance of occludin, claudin-4, zonula occludens (ZO) 1 and 2 by 0.5-2 fold but did not affect expression of claudin-1 or ZO-3 in IPEC-1 cells. Tryptophan 0-5 zonula occludens 1 Sus scrofa 75-104 19267955-7 2009 ZnO or TBZC significantly enhanced the mRNA and protein expression of occludin (P < 0.05) and zonula occludens protein-1 (ZO-1) (P < 0.05) in the ileal mucosa. Zinc Oxide 0-3 zonula occludens 1 Sus scrofa 97-123 25049991-7 2014 In addition, ZO-1 expression of IPEC-J2 cells treated with B. subtilis was up-regulated against DON-induced damage. deoxynivalenol 96-99 zonula occludens 1 Sus scrofa 13-17 21364771-5 2011 RESULTS: Application of DON in concentrations up to 4000 ng/mL for 24, 48 and 72 hours on the basolateral side of membrane cultured polarised IPEC-J2 cells resulted in a breakdown of the integrity of cell connections measured by transepithelial electrical resistance (TEER), as well as a reduced expression of the tight junction proteins ZO-1 and claudin 3. deoxynivalenol 24-27 zonula occludens 1 Sus scrofa 338-356 21812788-4 2012 Therefore, the purpose of this study was to analyse whether foetal and neonatal exposure to flutamide affects the expression and distribution of ZO-1, occludin, beta-catenin, and N-cadherin in testes of adult pigs. Flutamide 92-101 zonula occludens 1 Sus scrofa 145-149 21812788-7 2012 In the testes of all flutamide-exposed boars, expressions of ZO-1, N-cadherin and beta-catenin were significantly decreased at mRNA and protein level, whereas expression of occludin was unchanged when compared with the controls. Flutamide 21-30 zonula occludens 1 Sus scrofa 61-65 21812788-10 2012 Taken together, these results demonstrate that blockade of androgen action by flutamide during both gestational and neonatal periods affects the expression of ZO-1, N-cadherin and beta-catenin in adult pig testes. Flutamide 78-87 zonula occludens 1 Sus scrofa 159-163 19267955-9 2009 The results indicate that Zn supplementation decreased faecal scores and the reduction was accompanied by reduced intestinal permeability, which was evident from the reduced urinary lactulose:mannitol ratios and increased expression of occludin and ZO-1. Zinc 26-28 zonula occludens 1 Sus scrofa 249-253 19267955-7 2009 ZnO or TBZC significantly enhanced the mRNA and protein expression of occludin (P < 0.05) and zonula occludens protein-1 (ZO-1) (P < 0.05) in the ileal mucosa. Zinc Oxide 0-3 zonula occludens 1 Sus scrofa 125-129 19267955-7 2009 ZnO or TBZC significantly enhanced the mRNA and protein expression of occludin (P < 0.05) and zonula occludens protein-1 (ZO-1) (P < 0.05) in the ileal mucosa. tbzc 7-11 zonula occludens 1 Sus scrofa 97-123 19267955-7 2009 ZnO or TBZC significantly enhanced the mRNA and protein expression of occludin (P < 0.05) and zonula occludens protein-1 (ZO-1) (P < 0.05) in the ileal mucosa. tbzc 7-11 zonula occludens 1 Sus scrofa 125-129 34763738-7 2021 Specifically, comparing with ECON pigs, the level of GSH-Px (glutathione peroxidase) and CAT (catalase) in the plasma and intestinal mucosa of EFOS pigs was increased (P<0.05), and the intestinal barrier marked by ZO-1 and plasmatic DAO was also improved in EFOS pigs. gsh-px 53-59 zonula occludens 1 Sus scrofa 214-218 15493009-7 2005 Furthermore, the fraction of ZO-1 was distributed from the Triton X-100 insoluble to the Triton X-100 soluble pool. Octoxynol 59-71 zonula occludens 1 Sus scrofa 29-33 15493009-7 2005 Furthermore, the fraction of ZO-1 was distributed from the Triton X-100 insoluble to the Triton X-100 soluble pool. Octoxynol 89-101 zonula occludens 1 Sus scrofa 29-33 15493009-8 2005 After incubation at 37 degrees C for 12 h, cell contact and ZO-1 extractability with Triton X-100 returned to pre-HS conditions, but the recovery was completely prevented by phloridzin. Octoxynol 85-97 zonula occludens 1 Sus scrofa 60-64 15493009-11 2005 Furthermore, these inhibitors prevented the recovery of cell contact and ZO-1 extractability with Triton X-100 as same as phloridzin. Octoxynol 98-110 zonula occludens 1 Sus scrofa 73-77 34915950-4 2021 EPA and ARA increased transepithelial electrical resistance (TEER) and decreased permeability of fluorescein isothiocyanate-labeled dextran (FD4), and increased membrane protein expression of occludin, ZO-1 and claudin-1, and relieved disturbed distribution of these proteins. Eicosapentaenoic Acid 0-3 zonula occludens 1 Sus scrofa 202-206 34763738-7 2021 Specifically, comparing with ECON pigs, the level of GSH-Px (glutathione peroxidase) and CAT (catalase) in the plasma and intestinal mucosa of EFOS pigs was increased (P<0.05), and the intestinal barrier marked by ZO-1 and plasmatic DAO was also improved in EFOS pigs. efos 143-147 zonula occludens 1 Sus scrofa 214-218 34763738-7 2021 Specifically, comparing with ECON pigs, the level of GSH-Px (glutathione peroxidase) and CAT (catalase) in the plasma and intestinal mucosa of EFOS pigs was increased (P<0.05), and the intestinal barrier marked by ZO-1 and plasmatic DAO was also improved in EFOS pigs. efos 258-262 zonula occludens 1 Sus scrofa 214-218 34288130-9 2021 Moreover, LPS stimulation decreased the protein abundance of zona occludens 1 (ZO-1) and occludin, while pretreatment with gallic acid preserved expression level of tight junction proteins ZO-1 and occludin in LPS-stimulated IPEC-J2 cells (p < 0.05). Gallic Acid 123-134 zonula occludens 1 Sus scrofa 189-193 34438677-7 2021 Coated cysteamine supplementation showed an increasing trend in villus height (p = 0.060), villus height/crypt depth (V/C) (p = 0.056), the expression levels of zonula occludens-1 (ZO-1) mRNA (p = 0.061), and Occludin mRNA (p = 0.074) in the jejunum. Cysteamine 7-17 zonula occludens 1 Sus scrofa 161-179 34438677-7 2021 Coated cysteamine supplementation showed an increasing trend in villus height (p = 0.060), villus height/crypt depth (V/C) (p = 0.056), the expression levels of zonula occludens-1 (ZO-1) mRNA (p = 0.061), and Occludin mRNA (p = 0.074) in the jejunum. Cysteamine 7-17 zonula occludens 1 Sus scrofa 181-185 34140030-12 2021 In vitro, compared to cells cultured with H2O2, pre-treatment with PQQ increased cell viability, tight junction proteins expression including ZO-1, ZO-2, Occludin and Claudin-1; and decreased ROS concentration and level of Caspase-3 (P < 0.05); as well as upregulated the ratio of Bcl-2 to Bax and protein expression of nuclear Nrf2, HO-1. Hydrogen Peroxide 42-46 zonula occludens 1 Sus scrofa 142-146 34140030-12 2021 In vitro, compared to cells cultured with H2O2, pre-treatment with PQQ increased cell viability, tight junction proteins expression including ZO-1, ZO-2, Occludin and Claudin-1; and decreased ROS concentration and level of Caspase-3 (P < 0.05); as well as upregulated the ratio of Bcl-2 to Bax and protein expression of nuclear Nrf2, HO-1. PQQ Cofactor 67-70 zonula occludens 1 Sus scrofa 142-146 34605115-4 2021 The results showed that in diquat-treated piglets, supplementation of dietary GOD and CAT elevated the superoxide dismutase and CAT activities and attenuated the malondialdehyde level in plasma and intestinal mucosa, enhanced the duodenal villus height and villus height/crypt depth ratio, upregulated ZO-1 mRNA level, and attenuated the apoptosis of the epithelial cells and caspase-3 mRNA level in the intestine. Diquat 27-33 zonula occludens 1 Sus scrofa 302-306 35381244-5 2022 The results showed that low dose of NaAsO2 exacerbated DON-induced intestinal impairment by increasing intestinal permeability and decreasing the abundance of tight junction proteins (ZO-1, Occludin, Claudin-1). sodium arsenite 36-42 zonula occludens 1 Sus scrofa 184-188 35381244-5 2022 The results showed that low dose of NaAsO2 exacerbated DON-induced intestinal impairment by increasing intestinal permeability and decreasing the abundance of tight junction proteins (ZO-1, Occludin, Claudin-1). deoxynivalenol 55-58 zonula occludens 1 Sus scrofa 184-188 35204227-6 2022 However, ATRA treatment attenuated TGEV-induced IPEC-J2 cells damage by upregulating the mRNA expressions of ZO-1, Occludin, and Mucin-1. Tretinoin 9-13 zonula occludens 1 Sus scrofa 109-113