PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
32032542-3	2020	Here, we show that NLRP3, a pattern recognition receptor, is modified by acetylation in macrophages and is deacetylated by SIRT2, an NAD+-dependent deacetylase and a metabolic sensor.	NAD	133-136	sirtuin 2	Mus musculus	123-128
31973227-2	2020	Previously, we described the discovery of a dual SIRT1/SIRT2 inhibitor called cambinol (IC50 56 and 59 microM, respectively), which showed cytotoxic activity against cancer cells in vitro and a marked anti-proliferative effect in a Burkitt lymphoma mouse xenograft model.	cambinol	78-86	sirtuin 2	Mus musculus	55-60
31980591-0	2020	Melatonin ameliorates the advanced maternal age-associated meiotic defects in oocytes through the SIRT2-dependent H4K16 deacetylation pathway.	Melatonin	0-9	sirtuin 2	Mus musculus	98-103
31980591-5	2020	Furthermore, we identify SIRT2 as a critical effector mediating the effects of melatonin on meiotic structure in old oocytes.	Melatonin	79-88	sirtuin 2	Mus musculus	25-30
31980591-9	2020	To sum up, our data uncover that melatonin alleviates advanced maternal aged-associated meiotic defects in oocytes through the SIRT2-depenendet H4K16 deacetylation pathway.	Melatonin	33-42	sirtuin 2	Mus musculus	127-132
31973227-3	2020	A number of recent studies have shown a protective effect of SIRT1 and SIRT3 in neurodegenerative and metabolic diseases as well as in certain cancers prompting us to initiate a medicinal chemistry effort to develop cambinol-based SIRT2-specific inhibitors devoid of SIRT1 or SIRT3 modulating activity.	cambinol	216-224	sirtuin 2	Mus musculus	231-236
31973227-4	2020	Here we describe potent cambinol-based SIRT2 inhibitors, several of which show potency of ~600 nM with >300 to >800-fold selectivity over SIRT1 and 3, respectively.	cambinol	24-32	sirtuin 2	Mus musculus	39-44
31849939-6	2019	In vitro, SIRT2/3-/- macrophages favored fatty acid oxidation (FAO) over glycolysis and produced increased levels of both proinflammatory and anti-inflammatory cytokines.	Fatty Acids	41-51	sirtuin 2	Mus musculus	10-17
31954883-3	2020	We investigated the role of Sirtuin 2 (SIRT2), a NAD-dependent protein deacetylase, in intestinal epithelial cell (IEC) proliferation and differentiation and the mechanism by which SIRT2 contributes to maintenance of intestinal cell homeostasis METHODS: IECs were collected from SIRT2-deficient mice and patients with IBD.	NAD	49-52	sirtuin 2	Mus musculus	28-37
31954883-3	2020	We investigated the role of Sirtuin 2 (SIRT2), a NAD-dependent protein deacetylase, in intestinal epithelial cell (IEC) proliferation and differentiation and the mechanism by which SIRT2 contributes to maintenance of intestinal cell homeostasis METHODS: IECs were collected from SIRT2-deficient mice and patients with IBD.	NAD	49-52	sirtuin 2	Mus musculus	39-44
31471557-3	2020	To this end, the potent SIRT2-selective inhibitor, 33i (5 mg/kg i.p.	6-(4-amino-4-methylpiperidin-1-yl)-3-(3-chlorophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one	51-54	sirtuin 2	Mus musculus	24-29
31282756-4	2020	SIRT2 and SIRT3 expressions in DMH group were decreased in liver, colon, and kidney tissues and the decrease further stimulated by kumiss reinforcement.	1,2-Dimethylhydrazine	31-34	sirtuin 2	Mus musculus	0-5
30986062-0	2019	Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model.	Lysine	6-12	sirtuin 2	Mus musculus	62-71
31373792-3	2019	One of the best SIRT2-selective inhibitors reported is a thiomyristoyl lysine compound called TM, which showed promising anticancer activity in mouse models without much toxicity to normal cells.	thiomyristoyl lysine	57-77	sirtuin 2	Mus musculus	16-21
31373792-3	2019	One of the best SIRT2-selective inhibitors reported is a thiomyristoyl lysine compound called TM, which showed promising anticancer activity in mouse models without much toxicity to normal cells.	Thulium	94-96	sirtuin 2	Mus musculus	16-21
31373792-6	2019	Although glucose-TM is not cell permeable, the excellent aqueous solubility allowed us to obtain a crystal structure of SIRT2 in complex with it.	Glucose	9-16	sirtuin 2	Mus musculus	120-125
31129140-1	2019	AIMS: The aim of the present study was to investigate the protective effects of AGK2 as a selective SIRT2 inhibitor on thioacetamide (TAA)-induced acute liver failure (ALF) in mice and its potential mechanism.	Thioacetamide	119-132	sirtuin 2	Mus musculus	100-105
31144814-0	2019	Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the "Selectivity Pocket", Substrate-Binding Site, and NAD+-Binding Site.	Diketopiperazines	18-34	sirtuin 2	Mus musculus	76-85
31144814-0	2019	Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the "Selectivity Pocket", Substrate-Binding Site, and NAD+-Binding Site.	Diketopiperazines	18-34	sirtuin 2	Mus musculus	87-92
31144814-0	2019	Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the "Selectivity Pocket", Substrate-Binding Site, and NAD+-Binding Site.	2-anilinobenzamides	46-65	sirtuin 2	Mus musculus	76-85
31144814-0	2019	Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the "Selectivity Pocket", Substrate-Binding Site, and NAD+-Binding Site.	2-anilinobenzamides	46-65	sirtuin 2	Mus musculus	87-92
31144814-0	2019	Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the "Selectivity Pocket", Substrate-Binding Site, and NAD+-Binding Site.	NAD	179-183	sirtuin 2	Mus musculus	76-85
31144814-0	2019	Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the "Selectivity Pocket", Substrate-Binding Site, and NAD+-Binding Site.	NAD	179-183	sirtuin 2	Mus musculus	87-92
31144814-3	2019	This led us to develop a more drug-like diketopiperazine structure as a "hydrogen bond (H-bond) hunter" to target the substrate-binding site of SIRT2.	Diketopiperazines	40-56	sirtuin 2	Mus musculus	144-149
31144814-3	2019	This led us to develop a more drug-like diketopiperazine structure as a "hydrogen bond (H-bond) hunter" to target the substrate-binding site of SIRT2.	Hydrogen	73-81	sirtuin 2	Mus musculus	144-149
31144814-4	2019	Thioamide 53, a conjugate of diketopiperazine and 2-anilinobenzamide which is expected to occupy the "selectivity pocket" of SIRT2, exhibited potent SIRT2-selective inhibition.	Thioamides	0-9	sirtuin 2	Mus musculus	125-130
31144814-4	2019	Thioamide 53, a conjugate of diketopiperazine and 2-anilinobenzamide which is expected to occupy the "selectivity pocket" of SIRT2, exhibited potent SIRT2-selective inhibition.	Thioamides	0-9	sirtuin 2	Mus musculus	149-154
31144814-4	2019	Thioamide 53, a conjugate of diketopiperazine and 2-anilinobenzamide which is expected to occupy the "selectivity pocket" of SIRT2, exhibited potent SIRT2-selective inhibition.	Diketopiperazines	29-45	sirtuin 2	Mus musculus	125-130
31144814-4	2019	Thioamide 53, a conjugate of diketopiperazine and 2-anilinobenzamide which is expected to occupy the "selectivity pocket" of SIRT2, exhibited potent SIRT2-selective inhibition.	Diketopiperazines	29-45	sirtuin 2	Mus musculus	149-154
31144814-4	2019	Thioamide 53, a conjugate of diketopiperazine and 2-anilinobenzamide which is expected to occupy the "selectivity pocket" of SIRT2, exhibited potent SIRT2-selective inhibition.	2-(phenylamino)benzamide	50-68	sirtuin 2	Mus musculus	125-130
31144814-4	2019	Thioamide 53, a conjugate of diketopiperazine and 2-anilinobenzamide which is expected to occupy the "selectivity pocket" of SIRT2, exhibited potent SIRT2-selective inhibition.	2-(phenylamino)benzamide	50-68	sirtuin 2	Mus musculus	149-154
31144814-5	2019	Inhibition of SIRT2 by 53 was mediated by the formation of a 53-ADP-ribose conjugate, suggesting that 53 is a mechanism-based inhibitor targeting the "selectivity pocket", substrate-binding site, and NAD+-binding site.	53-adp-ribose	61-74	sirtuin 2	Mus musculus	14-19
31144814-5	2019	Inhibition of SIRT2 by 53 was mediated by the formation of a 53-ADP-ribose conjugate, suggesting that 53 is a mechanism-based inhibitor targeting the "selectivity pocket", substrate-binding site, and NAD+-binding site.	NAD	200-204	sirtuin 2	Mus musculus	14-19
30986062-0	2019	Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model.	Lysine	6-12	sirtuin 2	Mus musculus	73-78
30986062-3	2019	Here, we report the facile synthesis of novel lysine-derived thioureas as mechanism-based SIRT2 inhibitors with anticancer activity.	Lysine	46-52	sirtuin 2	Mus musculus	90-95
30021675-0	2019	Inactivation of Sirtuin2 protects mice from acetaminophen-induced liver injury: possible involvement of ER stress and S6K1 activation.	Acetaminophen	44-57	sirtuin 2	Mus musculus	16-24
30021675-4	2019	Moreover, the ablation of Sirt2 attenuates APAP-induced liver injuries, such as oxidative stress and mitochondrial damage in hepatocytes.	Acetaminophen	43-47	sirtuin 2	Mus musculus	26-31
30021675-5	2019	We found that Sirt2 deficiency alleviates the APAP-mediated endoplasmic reticulum (ER) stress and phosphorylation of the p70 ribosomal S6 kinase 1 (S6K1).	Acetaminophen	46-50	sirtuin 2	Mus musculus	14-19
30021675-7	2019	This study elucidates the molecular mechanisms underlying the protective role of Sirt2 inactivation in APAP-induced liver injuries.	Acetaminophen	103-107	sirtuin 2	Mus musculus	81-86
30203196-0	2019	Cysteine thiol oxidation on SIRT2 regulates inflammation in obese mice with sepsis.	Cysteine	0-8	sirtuin 2	Mus musculus	28-33
30203196-0	2019	Cysteine thiol oxidation on SIRT2 regulates inflammation in obese mice with sepsis.	Sulfhydryl Compounds	9-14	sirtuin 2	Mus musculus	28-33
30203196-12	2019	Direct oxidation modulates SIRT2 function during hyper-inflammatory phase of obesity with sepsis via redox sensitive cysteines.	Cysteine	117-126	sirtuin 2	Mus musculus	27-32
30483753-7	2019	Upregulation of miR-140-5p increased oxidative stress and ROS levels by suppressing the protein expression of nuclear factor erythroid 2-related factor 2 (Nrf2), sirtuin 2 (Sirt2), Kelch-like enoyl-CoA hydratase-associated protein 1 (Keap1) and heme oxygenase 1 (HO-1) in vitro.	Reactive Oxygen Species	58-61	sirtuin 2	Mus musculus	162-171
30483753-7	2019	Upregulation of miR-140-5p increased oxidative stress and ROS levels by suppressing the protein expression of nuclear factor erythroid 2-related factor 2 (Nrf2), sirtuin 2 (Sirt2), Kelch-like enoyl-CoA hydratase-associated protein 1 (Keap1) and heme oxygenase 1 (HO-1) in vitro.	Reactive Oxygen Species	58-61	sirtuin 2	Mus musculus	173-178
30483753-8	2019	By contrast, downregulation of miR-140-5p decreased oxidative stress and ROS levels by activating the protein expression of Nrf2, Sirt2, Keap1 and HO-1 in vitro.	Reactive Oxygen Species	73-76	sirtuin 2	Mus musculus	130-135
30761140-5	2019	Such increased alpha-tubulin acetylation was significantly suppressed either by resveratrol or NAD+ (coenzyme required for deacetylase activity of SIRT2), or by genetic knockdown of MEC-17 (gene encoding alpha-tubulin acetyltransferase 1).	NAD	95-99	sirtuin 2	Mus musculus	147-152
30487288-5	2019	We found that SIRT2 deacetylates cyclin-dependent kinase 9 (CDK9) in a type I IFN-dependent manner and that the CDK9 deacetylation is essential for STAT1 phosphorylation at Ser-727.	Serine	173-176	sirtuin 2	Mus musculus	14-19
31087297-3	2019	Although SIRT2 has been attributed both tumor-promoting and tumor-suppressing activities in different contexts, selective SIRT2 inhibition with a small molecule mechanism-based inhibitor known as Thiomyristoyl lysine (TM) repressed the growth of breast cancer cell lines.	thiomyristoyl lysine	196-216	sirtuin 2	Mus musculus	122-127
31087297-3	2019	Although SIRT2 has been attributed both tumor-promoting and tumor-suppressing activities in different contexts, selective SIRT2 inhibition with a small molecule mechanism-based inhibitor known as Thiomyristoyl lysine (TM) repressed the growth of breast cancer cell lines.	Thulium	218-220	sirtuin 2	Mus musculus	9-14
31087297-3	2019	Although SIRT2 has been attributed both tumor-promoting and tumor-suppressing activities in different contexts, selective SIRT2 inhibition with a small molecule mechanism-based inhibitor known as Thiomyristoyl lysine (TM) repressed the growth of breast cancer cell lines.	Thulium	218-220	sirtuin 2	Mus musculus	122-127
30533032-1	2018	The NAD+-dependent deacetylase SIRT2 is unique amongst sirtuins as it is effective in the cytosol, as well as the mitochondria.	NAD	4-7	sirtuin 2	Mus musculus	31-36
30102915-0	2018	High glucose concentration suppresses a SIRT2 regulated pathway that enhances neurite outgrowth in cultured adult sensory neurons.	Glucose	5-12	sirtuin 2	Mus musculus	40-45
29654491-1	2018	Sirtuin 2 (SIRT2) is a family member of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases which appears to have detrimental roles in an array of neurological disorders such as Parkinson"s disease (PD) and Huntington"s disease (HD).	NAD	40-73	sirtuin 2	Mus musculus	0-9
29654491-1	2018	Sirtuin 2 (SIRT2) is a family member of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases which appears to have detrimental roles in an array of neurological disorders such as Parkinson"s disease (PD) and Huntington"s disease (HD).	NAD	40-73	sirtuin 2	Mus musculus	11-16
29654491-1	2018	Sirtuin 2 (SIRT2) is a family member of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases which appears to have detrimental roles in an array of neurological disorders such as Parkinson"s disease (PD) and Huntington"s disease (HD).	NAD	75-78	sirtuin 2	Mus musculus	0-9
29654491-1	2018	Sirtuin 2 (SIRT2) is a family member of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases which appears to have detrimental roles in an array of neurological disorders such as Parkinson"s disease (PD) and Huntington"s disease (HD).	NAD	75-78	sirtuin 2	Mus musculus	11-16
30533032-5	2018	SIRT2 KO mice exhibited reduced skeletal muscle insulin-induced glucose uptake compared to lean WT mice, and this impairment was exacerbated in HF SIRT2 KO mice.	Glucose	64-71	sirtuin 2	Mus musculus	0-5
30405152-0	2018	Loss of Sirt2 increases and prolongs a caerulein-induced pancreatitis permissive phenotype and induces spontaneous oncogenic Kras mutations in mice.	Ceruletide	39-48	sirtuin 2	Mus musculus	8-13
30405152-2	2018	Here, we report that after caerulein-induced pancreatitis, Sirt2-deficient mice exhibited an increased inflammatory phenotype and delayed pancreatic tissue recovery.	Ceruletide	27-36	sirtuin 2	Mus musculus	59-64
30405152-6	2018	Importantly, an accumulation of a cell population with spontaneous cancerous KrasG12D mutations was observed in the Sirt2-/- mice that is enhanced in the recovering pancreas after exposure to caerulein.	Ceruletide	192-201	sirtuin 2	Mus musculus	116-121
30102915-2	2018	Sirtuins, including SIRT2, detect the redox state via the NAD+/NADH ratio to regulate mitochondrial function via, in part, AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha).	NAD	58-62	sirtuin 2	Mus musculus	20-25
30102915-2	2018	Sirtuins, including SIRT2, detect the redox state via the NAD+/NADH ratio to regulate mitochondrial function via, in part, AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha).	NAD	63-67	sirtuin 2	Mus musculus	20-25
30102915-4	2018	We tested the hypothesis that a high concentration of d-glucose depleted SIRT2 expression via enhancement of polyol pathway activity.	Glucose	54-63	sirtuin 2	Mus musculus	73-78
30102915-9	2018	After 72 h exposure to high d-glucose (25 mM vs 5 mM) cultured sensory neurons showed a significant 2-fold (p < .05) decrease in SIRT2 expression, P-AMPK, levels of respiratory Complexes II/III and respiratory capacity.	Glucose	28-37	sirtuin 2	Mus musculus	132-137
30364275-0	2018	MicroRNA-212-5p Prevents Dopaminergic Neuron Death by Inhibiting SIRT2 in MPTP-Induced Mouse Model of Parkinson"s Disease.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	74-78	sirtuin 2	Mus musculus	65-70
29752296-7	2018	In addition, in vitro supplementation with melatonin significantly upregulated the expression of SIRT1 and antioxidant enzyme MnSOD, but this action was not observed for SIRT2 and SIRT3.	Melatonin	43-52	sirtuin 2	Mus musculus	170-175
29449643-8	2018	Mechanistically, SIRT2-dependent deacetylation enhances ATP binding and enzymatic activity of JNK towards c-Jun.	Adenosine Triphosphate	56-59	sirtuin 2	Mus musculus	17-22
29449643-13	2018	Interestingly, SIRT2-KO mice were resistant to acetaminophen-induced liver toxicity.	Acetaminophen	47-60	sirtuin 2	Mus musculus	15-20
29449643-14	2018	SIRT2-KO mice show lower cell death, minimal degenerative changes, improved liver function and survival following acetaminophen treatment.	Acetaminophen	114-127	sirtuin 2	Mus musculus	0-5
28970254-6	2018	Both MEC-17 and sirtuin 2 (SIRT2) were influenced by palmitate and silybin, whereas histone deacetylase 6 was not affected.	Palmitates	53-62	sirtuin 2	Mus musculus	16-25
29067790-4	2018	Candidate screening revealed that acetylation state of lysine 243 on BubR1 (BubR1-K243, an integral part of the spindle assembly checkpoint complex) functions during oocyte meiosis, and acetylation-mimetic mutant BubR1-K243Q results in the very similar phenotypes as Sirt2-knockdown oocytes.	Lysine	55-61	sirtuin 2	Mus musculus	267-272
29440391-3	2018	Sirtuin 2 (SIRT2) is a cytoplasmic protein in the family of sirtuins that are NAD+-dependent class III histone deacetylases.	NAD	78-82	sirtuin 2	Mus musculus	0-9
29440391-3	2018	Sirtuin 2 (SIRT2) is a cytoplasmic protein in the family of sirtuins that are NAD+-dependent class III histone deacetylases.	NAD	78-82	sirtuin 2	Mus musculus	11-16
29504933-6	2018	We found that SIRT2 deacetylates GSK3beta, and thus enhances its binding to ATP.	Adenosine Triphosphate	76-79	sirtuin 2	Mus musculus	14-19
29158185-7	2018	We found that a lack of Sirt2 blocked the development of SDS-induced depressive-like behavior.	sds	57-60	sirtuin 2	Mus musculus	24-29
29158185-8	2018	Moreover, SDS led to Sirt2 phosphorylation in the amygdala without changing total Sirt2 levels, and blocking the phosphorylation of Sirt2 by CDK5 at serine residues 368 and 372 prevented SDS-induced depressive-like behavior and Sirt2 nuclear import.	sds	10-13	sirtuin 2	Mus musculus	21-26
29158185-9	2018	We also discovered that SDS-induced Sirt2 phosphorylation was involved in VTA-amygdala modulation using TetTag-pharmacogenetic method.	sds	24-27	sirtuin 2	Mus musculus	36-41
29158185-9	2018	We also discovered that SDS-induced Sirt2 phosphorylation was involved in VTA-amygdala modulation using TetTag-pharmacogenetic method.	tettag	104-110	sirtuin 2	Mus musculus	36-41
29158185-10	2018	These results suggest that CDK5 mediates phosphorylation of Sirt2 in the amygdala and contributes to the depressive-like behavior induced by SDS.	sds	141-144	sirtuin 2	Mus musculus	60-65
29158185-11	2018	This study highlights that inhibiting CDK5-dependent phosphorylation of Sirt2 at serine residues 368 and 372 by myristoylated membrane-permeabilising peptide (Sirt2-p), rather than using non-specific sirtuin inhibitors, may be a novel strategy for treating depression.	Serine	81-87	sirtuin 2	Mus musculus	72-77
28970254-6	2018	Both MEC-17 and sirtuin 2 (SIRT2) were influenced by palmitate and silybin, whereas histone deacetylase 6 was not affected.	Palmitates	53-62	sirtuin 2	Mus musculus	27-32
28970254-7	2018	In addition, supplementing NAD+ directly or increasing NAD+ concentration with silybin could maintain the activity of SIRT2.	NAD	27-31	sirtuin 2	Mus musculus	118-123
28970254-7	2018	In addition, supplementing NAD+ directly or increasing NAD+ concentration with silybin could maintain the activity of SIRT2.	NAD	55-59	sirtuin 2	Mus musculus	118-123
28970254-8	2018	The anti-inflammatory effect of silybin was blocked by SIRT2 silencing or by the SIRT2 inhibitor AGK2, as evidenced by NLRP3/ASC colocalization, AC-alpha-tubulin expression, and IL-1beta release.	Silybin	32-39	sirtuin 2	Mus musculus	55-60
28970254-8	2018	The anti-inflammatory effect of silybin was blocked by SIRT2 silencing or by the SIRT2 inhibitor AGK2, as evidenced by NLRP3/ASC colocalization, AC-alpha-tubulin expression, and IL-1beta release.	Silybin	32-39	sirtuin 2	Mus musculus	81-86
28168426-6	2018	These data were validated using MPTP-treated sirtuin-2 knock-out mice, where no alterations in motor behavior were observed.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	32-36	sirtuin 2	Mus musculus	45-54
28970254-0	2018	Silybin inhibits NLRP3 inflammasome assembly through the NAD+/SIRT2 pathway in mice with nonalcoholic fatty liver disease.	Silybin	0-7	sirtuin 2	Mus musculus	62-67
29189472-0	2018	SIRT2 and Akt mediate NAD+-induced and NADH-induced increases in the intracellular ATP levels of BV2 microglia under basal conditions.	NAD	22-26	sirtuin 2	Mus musculus	0-5
29189472-0	2018	SIRT2 and Akt mediate NAD+-induced and NADH-induced increases in the intracellular ATP levels of BV2 microglia under basal conditions.	NAD	39-43	sirtuin 2	Mus musculus	0-5
29189472-0	2018	SIRT2 and Akt mediate NAD+-induced and NADH-induced increases in the intracellular ATP levels of BV2 microglia under basal conditions.	Adenosine Triphosphate	83-86	sirtuin 2	Mus musculus	0-5
29189472-4	2018	We found that both NAD and NADH significantly increased the intracellular ATP levels of BV2 microglia, which were attenuated by SIRT2 siRNA, the SIRT2 inhibitor AGK2, and the phosphatidylinositol 3-kinase/Akt inhibitor LY294002.	NAD	19-22	sirtuin 2	Mus musculus	128-133
29189472-4	2018	We found that both NAD and NADH significantly increased the intracellular ATP levels of BV2 microglia, which were attenuated by SIRT2 siRNA, the SIRT2 inhibitor AGK2, and the phosphatidylinositol 3-kinase/Akt inhibitor LY294002.	NAD	19-22	sirtuin 2	Mus musculus	145-150
29189472-4	2018	We found that both NAD and NADH significantly increased the intracellular ATP levels of BV2 microglia, which were attenuated by SIRT2 siRNA, the SIRT2 inhibitor AGK2, and the phosphatidylinositol 3-kinase/Akt inhibitor LY294002.	NAD	27-31	sirtuin 2	Mus musculus	128-133
29189472-4	2018	We found that both NAD and NADH significantly increased the intracellular ATP levels of BV2 microglia, which were attenuated by SIRT2 siRNA, the SIRT2 inhibitor AGK2, and the phosphatidylinositol 3-kinase/Akt inhibitor LY294002.	NAD	27-31	sirtuin 2	Mus musculus	145-150
29189472-4	2018	We found that both NAD and NADH significantly increased the intracellular ATP levels of BV2 microglia, which were attenuated by SIRT2 siRNA, the SIRT2 inhibitor AGK2, and the phosphatidylinositol 3-kinase/Akt inhibitor LY294002.	Adenosine Triphosphate	74-77	sirtuin 2	Mus musculus	128-133
29189472-4	2018	We found that both NAD and NADH significantly increased the intracellular ATP levels of BV2 microglia, which were attenuated by SIRT2 siRNA, the SIRT2 inhibitor AGK2, and the phosphatidylinositol 3-kinase/Akt inhibitor LY294002.	Adenosine Triphosphate	74-77	sirtuin 2	Mus musculus	145-150
29189472-4	2018	We found that both NAD and NADH significantly increased the intracellular ATP levels of BV2 microglia, which were attenuated by SIRT2 siRNA, the SIRT2 inhibitor AGK2, and the phosphatidylinositol 3-kinase/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	219-227	sirtuin 2	Mus musculus	128-133
29189472-5	2018	Our study has also suggested that SIRT2 mediates the NAD-induced and NADH-induced increase in Akt phosphorylation in BV2 microglia.	NAD	53-56	sirtuin 2	Mus musculus	34-39
29189472-5	2018	Our study has also suggested that SIRT2 mediates the NAD-induced and NADH-induced increase in Akt phosphorylation in BV2 microglia.	NAD	69-73	sirtuin 2	Mus musculus	34-39
29189472-6	2018	Collectively, our study has suggested that SIRT2 mediates both NAD-induced and NADH-induced increases in the intracellular ATP levels of BV2 microglia by modulating Akt phosphorylation.	NAD	63-66	sirtuin 2	Mus musculus	43-48
29189472-6	2018	Collectively, our study has suggested that SIRT2 mediates both NAD-induced and NADH-induced increases in the intracellular ATP levels of BV2 microglia by modulating Akt phosphorylation.	NAD	79-83	sirtuin 2	Mus musculus	43-48
29189472-6	2018	Collectively, our study has suggested that SIRT2 mediates both NAD-induced and NADH-induced increases in the intracellular ATP levels of BV2 microglia by modulating Akt phosphorylation.	Adenosine Triphosphate	123-126	sirtuin 2	Mus musculus	43-48
29296001-0	2018	Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein.	Glucose	26-33	sirtuin 2	Mus musculus	0-5
29296001-5	2018	Sirt2 promotes glucose-dependent HGU by deacetylating K126 of glucokinase regulatory protein (GKRP).	Glucose	15-22	sirtuin 2	Mus musculus	0-5
29296001-5	2018	Sirt2 promotes glucose-dependent HGU by deacetylating K126 of glucokinase regulatory protein (GKRP).	N-(2-chloro-4-pyridyl)-N'-phenylurea	54-58	sirtuin 2	Mus musculus	0-5
29296001-6	2018	Glucokinase and GKRP glucose-dependent dissociation is necessary for HGU but is inhibited in hepatocytes derived from obese diabetic mice, depleted of Sirt2 or transfected with GKRP acetylation-mimicking mutants.	Glucose	21-28	sirtuin 2	Mus musculus	151-156
28778545-2	2017	Among them, we have recently identified SIRT2, a class III NAD+-dependent HDAC, as being oppositely regulated by stress and antidepressants.	NAD	59-63	sirtuin 2	Mus musculus	40-45
29145149-2	2018	SIRT2, an NAD+-dependent sirtuin deacetylase, is involved in modulating macrophage polarization.	NAD	10-14	sirtuin 2	Mus musculus	0-5
28828594-0	2018	Does Sirt2 Regulate Cholesterol Biosynthesis During Oligodendroglial Differentiation In Vitro and In Vivo?	Cholesterol	20-31	sirtuin 2	Mus musculus	5-10
28828594-3	2018	SIRT2 has been implicated in cholesterol biosynthesis by promoting the nuclear translocation of sterol regulatory element binding protein (SREBP)-2.	Cholesterol	29-40	sirtuin 2	Mus musculus	0-5
28828594-4	2018	We investigated this further in CNS myelination by examining the role of Sirt2 in cholesterol biosynthesis in vivo and in vitro employing Sirt2 -/- mice, primary OL cells and CG4-OL cells.	Cholesterol	82-93	sirtuin 2	Mus musculus	73-78
29614506-9	2018	SIRT2 inhibition ameliorated TIF in UUO mice.	Erythrosin(E)	29-32	sirtuin 2	Mus musculus	0-5
28947430-6	2017	Metformin (200 mg/kg/d) was used to treat wild-type and Sirt2 knockout mice infused with Ang II.	Metformin	0-9	sirtuin 2	Mus musculus	56-61
28947430-13	2017	SIRT2 bound to LKB1 and deacetylated it at lysine 48, which promoted the phosphorylation of LKB1 and the subsequent activation of LKB1-AMPK signaling.	Lysine	43-49	sirtuin 2	Mus musculus	0-5
27796760-0	2017	Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke.	NAD	18-21	sirtuin 2	Mus musculus	44-49
27796760-4	2017	SIRT2 was upregulated in ischemic neurons in the oxygen-glucose deprivation cell model and in the transient middle cerebral artery occlusion (tMCAo) mouse model.	oxygen-glucose	49-63	sirtuin 2	Mus musculus	0-5
27796760-4	2017	SIRT2 was upregulated in ischemic neurons in the oxygen-glucose deprivation cell model and in the transient middle cerebral artery occlusion (tMCAo) mouse model.	tmcao	142-147	sirtuin 2	Mus musculus	0-5
27796760-7	2017	Downregulation of SIRT2 using the SIRT2-specific inhibitor AGK2 or SIRT2 knockout had neuroprotective effects in tMCAo model, which could decrease the infract volume and neurological impairment scores.	tmcao	113-118	sirtuin 2	Mus musculus	18-23
27796760-7	2017	Downregulation of SIRT2 using the SIRT2-specific inhibitor AGK2 or SIRT2 knockout had neuroprotective effects in tMCAo model, which could decrease the infract volume and neurological impairment scores.	tmcao	113-118	sirtuin 2	Mus musculus	34-39
27796760-7	2017	Downregulation of SIRT2 using the SIRT2-specific inhibitor AGK2 or SIRT2 knockout had neuroprotective effects in tMCAo model, which could decrease the infract volume and neurological impairment scores.	tmcao	113-118	sirtuin 2	Mus musculus	34-39
28778545-10	2017	While repeated imipramine showed an anti-anhedonic action in both VGLUT1+/- and WT, the selective SIRT2 inhibitor 33i fully reversed anhedonia of VGLUT1+/-.	6-(4-amino-4-methylpiperidin-1-yl)-3-(3-chlorophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one	114-117	sirtuin 2	Mus musculus	98-103
28478325-6	2017	Thus, SIRT2 acts as a novel regulator of the differentiation process of DA neurons, further supporting its potential as a therapeutic target in Parkinson"s disease.	Dopamine	72-74	sirtuin 2	Mus musculus	6-11
28894448-1	2017	Sirtuin 2 (SIRT2) is one of the seven members of the family of NAD+-dependent histone deacetylases.	NAD	63-66	sirtuin 2	Mus musculus	0-9
28894448-1	2017	Sirtuin 2 (SIRT2) is one of the seven members of the family of NAD+-dependent histone deacetylases.	NAD	63-66	sirtuin 2	Mus musculus	11-16
28793258-9	2017	These findings establish SIRT2-regulated lysine acetylation as a form of AMPAR post-translational modification that regulates its turnover, as well as synaptic plasticity and cognitive function.	Lysine	41-47	sirtuin 2	Mus musculus	25-30
28478325-2	2017	Here, we established that the nicotinamide adenine dinucleotide-dependent deacetylase sirtuin 2 (SIRT2) interacts with protein kinase B, and, via the glycogen synthase kinase 3beta/beta-catenin pathway, modulates the differentiation of DA neurons.	Niacinamide	30-42	sirtuin 2	Mus musculus	86-95
28478325-2	2017	Here, we established that the nicotinamide adenine dinucleotide-dependent deacetylase sirtuin 2 (SIRT2) interacts with protein kinase B, and, via the glycogen synthase kinase 3beta/beta-catenin pathway, modulates the differentiation of DA neurons.	Niacinamide	30-42	sirtuin 2	Mus musculus	97-102
28478325-2	2017	Here, we established that the nicotinamide adenine dinucleotide-dependent deacetylase sirtuin 2 (SIRT2) interacts with protein kinase B, and, via the glycogen synthase kinase 3beta/beta-catenin pathway, modulates the differentiation of DA neurons.	Dopamine	236-238	sirtuin 2	Mus musculus	86-95
28478325-2	2017	Here, we established that the nicotinamide adenine dinucleotide-dependent deacetylase sirtuin 2 (SIRT2) interacts with protein kinase B, and, via the glycogen synthase kinase 3beta/beta-catenin pathway, modulates the differentiation of DA neurons.	Dopamine	236-238	sirtuin 2	Mus musculus	97-102
28478325-3	2017	Deletion of SIRT2 resulted in a decreased number of DA neurons in the substantia nigra and lower striatal fiber density in SIRT2 knock-out mice.	Dopamine	52-54	sirtuin 2	Mus musculus	12-17
28947430-14	2017	Remarkably, the loss of SIRT2 blunted the response of AMPK to metformin treatment in mice infused with Ang II and repressed the metformin-mediated reduction of cardiac hypertrophy and protection of cardiac function.	Metformin	62-71	sirtuin 2	Mus musculus	24-29
28947430-14	2017	Remarkably, the loss of SIRT2 blunted the response of AMPK to metformin treatment in mice infused with Ang II and repressed the metformin-mediated reduction of cardiac hypertrophy and protection of cardiac function.	Metformin	128-137	sirtuin 2	Mus musculus	24-29
28947430-16	2017	Loss of SIRT2 reduces AMPK activation, promotes aging-related and Ang II-induced cardiac hypertrophy, and blunts metformin-mediated cardioprotective effects.	Metformin	113-122	sirtuin 2	Mus musculus	8-13
27460777-2	2017	Currently, only the mitochondrial sirtuins (SIRT3-5) and SIRT1 have been shown to direct mitochondrial function; however, Aims: NAD-dependent protein deacetylase sirtuin-2 (SIRT2), the primary cytoplasmic sirtuin, is not yet reported to associate with mitochondria.	NAD	128-131	sirtuin 2	Mus musculus	162-171
28478325-4	2017	Similarly, we found a decreased ratio of DA neurons in primary midbrain cultures treated with the SIRT2 inhibitor AK-7.	Dopamine	41-43	sirtuin 2	Mus musculus	98-103
28526407-6	2017	Treatment with sirtinol significantly reduced the rates of morula (21.34 +- 1.84 vs. 11.89 +- 2.01), blastocyst development (17.18 +- 1.81 vs. 9.00 +- 2.02), and total cell number (50.80 +- 1.47 vs. 37.71 +- 1.79), compared to controls, with an associating decrease the levels of Sirt2 transcript.	sirtinol	15-23	sirtuin 2	Mus musculus	280-285
27460777-6	2017	The loss of Sirt2 increased oxidative stress, decreased adenosine triphosphate levels, and altered mitochondrial morphology at the cellular and tissue (i.e., brain) level.	Adenosine Triphosphate	56-78	sirtuin 2	Mus musculus	12-17
27833050-12	2017	HIB 1B cells treated with EPA showed significantly higher mRNA expression of PGC1alpha and SIRT2.	Eicosapentaenoic Acid	26-29	sirtuin 2	Mus musculus	91-96
28185898-13	2017	These results suggest that Sirt2 inhibition induce antidepressant-like action and this effect could be mediated by modulation of glutamate and serotonin system in the PFC.	Glutamic Acid	129-138	sirtuin 2	Mus musculus	27-32
28185898-13	2017	These results suggest that Sirt2 inhibition induce antidepressant-like action and this effect could be mediated by modulation of glutamate and serotonin system in the PFC.	Serotonin	143-152	sirtuin 2	Mus musculus	27-32
28088387-7	2017	Shikonin inhibited the viability, migration and invasion of SW480 cells and it also inhibited the tumor growth in the nude mice model; while AGK2 (a specific inhibitor of SIRT2) reversed these effects.	shikonin	0-8	sirtuin 2	Mus musculus	171-176
28185898-0	2017	SIRT2 inhibition modulate glutamate and serotonin systems in the prefrontal cortex and induces antidepressant-like action.	Glutamic Acid	26-35	sirtuin 2	Mus musculus	0-5
28185898-0	2017	SIRT2 inhibition modulate glutamate and serotonin systems in the prefrontal cortex and induces antidepressant-like action.	Serotonin	40-49	sirtuin 2	Mus musculus	0-5
28185898-5	2017	The compound 2-{3-(3-fluorophenethyloxy)phenylamino}benzamide (33i), a selective SIRT2 inhibitor in vitro, was studied in mice (C57Bl6).	2-(3-(3-fluorophenethyloxy)phenylamino)benzamide	63-66	sirtuin 2	Mus musculus	81-86
28185898-6	2017	Firstly, the inhibitory effect of subchronic 33i (5-15 mg/kg, 10 days) on SIRT2 activity in the PFC was evaluated.	2-(3-(3-fluorophenethyloxy)phenylamino)benzamide	45-48	sirtuin 2	Mus musculus	74-79
28185898-7	2017	Moreover, the effect of SIRT2 inhibition on the expression of synaptic plasticity markers linked to glutamate neurotransmission (VGLUT1, synaptophysin, mGluR4, GluA1, GluN2B, GluN2A) and on serotonin levels was studied.	Glutamic Acid	100-109	sirtuin 2	Mus musculus	24-29
28287409-0	2017	Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2.	Iron	29-33	sirtuin 2	Mus musculus	0-9
28287409-2	2017	Since these processes require iron, we hypothesized that SIRT2 directly regulates cellular iron homeostasis.	Iron	30-34	sirtuin 2	Mus musculus	57-62
28287409-2	2017	Since these processes require iron, we hypothesized that SIRT2 directly regulates cellular iron homeostasis.	Iron	91-95	sirtuin 2	Mus musculus	57-62
28287409-3	2017	Here, we have demonstrated that SIRT2 depletion results in a decrease in cellular iron levels both in vitro and in vivo.	Iron	82-86	sirtuin 2	Mus musculus	32-37
28287409-4	2017	Mechanistically, we determined that SIRT2 maintains cellular iron levels by binding to and deacetylating nuclear factor erythroid-derived 2-related factor 2 (NRF2) on lysines 506 and 508, leading to a reduction in total and nuclear NRF2 levels.	Iron	61-65	sirtuin 2	Mus musculus	36-41
28287409-4	2017	Mechanistically, we determined that SIRT2 maintains cellular iron levels by binding to and deacetylating nuclear factor erythroid-derived 2-related factor 2 (NRF2) on lysines 506 and 508, leading to a reduction in total and nuclear NRF2 levels.	Lysine	167-174	sirtuin 2	Mus musculus	36-41
28287409-6	2017	Finally, we observed that Sirt2 deletion reduced cell viability in response to iron deficiency.	Iron	79-83	sirtuin 2	Mus musculus	26-31
28287409-7	2017	Moreover, livers from Sirt2-/- mice had decreased iron levels, while this effect was reversed in Sirt2-/- Nrf2-/- double-KO mice.	Iron	50-54	sirtuin 2	Mus musculus	22-27
26896748-6	2016	The acetylation of histone 3 at lysine residues 56 (H3K56), H3K14, H3K9, and H3K27, putative substrates of SIRT2 and SIRT6, was increased by maternal diabetes in vivo or high glucose in vitro, and these increases were blocked by SOD1 over-expression or tempol treatment.	Lysine	32-38	sirtuin 2	Mus musculus	107-112
27235848-7	2016	Furthermore, we observed that MPTP treatment resulted in significant reduction in GSH content and significant increase in MDA content and SIRT2 expression in the substantia nigra (SN) of aging mice, while it did not do so in young animals.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	30-34	sirtuin 2	Mus musculus	138-143
27235848-8	2016	Importantly, we observed that AK-7 (a selective SIRT2 inhibitor) significantly improved behavior abnormality and neurochemical deficits in aging male and female mice treated with MPTP.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	179-183	sirtuin 2	Mus musculus	48-53
26896748-3	2016	Among the seven sirtuins (SIRT1-7), pre-gestational maternal diabetes in vivo or high glucose in vitro significantly reduced the expression of SIRT 2 and SIRT6 in the embryo or neural stem cells, respectively.	Glucose	86-93	sirtuin 2	Mus musculus	143-149
28053616-9	2016	In addition, sodium butyrate reverses SIRT2-related age phenotypes.	Butyric Acid	13-28	sirtuin 2	Mus musculus	38-43
27197174-5	2016	Enabled by a shotgun mass spectrometry analysis founded on tissue culture models, we identified a candidate SIRT2 deacetylation target at PKM2 lysine 305 (K305).	Lysine	143-149	sirtuin 2	Mus musculus	108-113
27197174-5	2016	Enabled by a shotgun mass spectrometry analysis founded on tissue culture models, we identified a candidate SIRT2 deacetylation target at PKM2 lysine 305 (K305).	Fmoc-Lys(Tfa)-OH	155-159	sirtuin 2	Mus musculus	108-113
26896748-6	2016	The acetylation of histone 3 at lysine residues 56 (H3K56), H3K14, H3K9, and H3K27, putative substrates of SIRT2 and SIRT6, was increased by maternal diabetes in vivo or high glucose in vitro, and these increases were blocked by SOD1 over-expression or tempol treatment.	Glucose	175-182	sirtuin 2	Mus musculus	107-112
26896748-5	2016	2,3-dimethoxy-1,4-naphthoquinone (DMNQ), a superoxide generating agent, mimicked high glucose-suppressed SIRT2 and SIRT6 expression.	2,3-dimethoxy-1,4-naphthoquinone	0-32	sirtuin 2	Mus musculus	105-110
26896748-5	2016	2,3-dimethoxy-1,4-naphthoquinone (DMNQ), a superoxide generating agent, mimicked high glucose-suppressed SIRT2 and SIRT6 expression.	2,3-dimethoxy-1,4-naphthoquinone	34-38	sirtuin 2	Mus musculus	105-110
26896748-7	2016	SIRT2 or SIRT6 over-expression abrogated high glucose-suppressed SIRT2 or SIRT6 expression, and prevented the increase in acetylation of their histone substrates.	Glucose	46-53	sirtuin 2	Mus musculus	0-5
26896748-5	2016	2,3-dimethoxy-1,4-naphthoquinone (DMNQ), a superoxide generating agent, mimicked high glucose-suppressed SIRT2 and SIRT6 expression.	Superoxides	43-53	sirtuin 2	Mus musculus	105-110
26896748-5	2016	2,3-dimethoxy-1,4-naphthoquinone (DMNQ), a superoxide generating agent, mimicked high glucose-suppressed SIRT2 and SIRT6 expression.	Glucose	86-93	sirtuin 2	Mus musculus	105-110
26896748-7	2016	SIRT2 or SIRT6 over-expression abrogated high glucose-suppressed SIRT2 or SIRT6 expression, and prevented the increase in acetylation of their histone substrates.	Glucose	46-53	sirtuin 2	Mus musculus	65-70
26896748-9	2016	Thus, diabetes in vivo or high glucose in vitro suppresses SIRT2 and SIRT6 expression through oxidative stress, and sirtuin down-regulation-induced histone acetylation may be involved in diabetes-induced NTDs.	Glucose	31-38	sirtuin 2	Mus musculus	59-64
26060246-10	2015	Knockdown of NAD-dependent deacetylase sirtuin 1 (SIRT1) and SIRT2 inhibited the progrowth action of Nampt-NAD axis, whereas knockdown of SIRT1, SIRT2, and SIRT6 compromised the prodifferentiation effect of Nampt-NAD axis.	NAD	13-16	sirtuin 2	Mus musculus	145-150
26001219-7	2016	Use of a pan-sirtuin inhibitor and shRNA-mediated protein knockdown led us to uncover a role for the NAD(+)-dependent family of sirtuins, and in particular for SIRT2 and SIRT5, in the regulation of the necroptotic cell death program.	NAD	101-107	sirtuin 2	Mus musculus	160-165
26522013-2	2016	Sirt2 activation produces O-acetylated-ADPribose (OAADPr) which can act as a ligand for transient receptor potential cation channel, M2 (TRPM2).	Adenosine Diphosphate Ribose	38-48	sirtuin 2	Mus musculus	0-5
26522013-2	2016	Sirt2 activation produces O-acetylated-ADPribose (OAADPr) which can act as a ligand for transient receptor potential cation channel, M2 (TRPM2).	O-Acetyl-ADP-Ribose	50-56	sirtuin 2	Mus musculus	0-5
26620281-7	2015	Deacetylation of GKRP is effected by the NAD(+)-dependent, class III histone deacetylase SIRT2, which is inhibited by nicotinamide.	NAD	41-47	sirtuin 2	Mus musculus	89-94
26620281-7	2015	Deacetylation of GKRP is effected by the NAD(+)-dependent, class III histone deacetylase SIRT2, which is inhibited by nicotinamide.	Niacinamide	118-130	sirtuin 2	Mus musculus	89-94
26546505-11	2016	Mechanistically, SIRT2 inhibition increased both K310 acetylation and nuclear translocation of NF-kappaB p65, leading to enhanced NF-kappaB activation and up-regulation of its target genes, including aquaporin 4 (AQP4), MMP-9, and pro-inflammatory cytokines.	L-arabinitol	49-53	sirtuin 2	Mus musculus	17-22
26442099-6	2015	Furthermore, 4 weeks of chronic CIT treatment started at 8 weeks of age also increased sirt2 and sirt4 mRNA expression in the POA.	Citalopram	32-35	sirtuin 2	Mus musculus	87-92
25871950-9	2015	Metformin inhibited SirT2 expression in WBCs significantly (P<0.05) and did not induce any significant changes in other SirT forms and p53, whereas it induced p16(INK4a) mRNA expression in WBCs (P<0.05) at the basal levels.	Metformin	0-9	sirtuin 2	Mus musculus	20-25
26060246-10	2015	Knockdown of NAD-dependent deacetylase sirtuin 1 (SIRT1) and SIRT2 inhibited the progrowth action of Nampt-NAD axis, whereas knockdown of SIRT1, SIRT2, and SIRT6 compromised the prodifferentiation effect of Nampt-NAD axis.	NAD	107-110	sirtuin 2	Mus musculus	61-66
26060246-10	2015	Knockdown of NAD-dependent deacetylase sirtuin 1 (SIRT1) and SIRT2 inhibited the progrowth action of Nampt-NAD axis, whereas knockdown of SIRT1, SIRT2, and SIRT6 compromised the prodifferentiation effect of Nampt-NAD axis.	NAD	107-110	sirtuin 2	Mus musculus	145-150
26060246-10	2015	Knockdown of NAD-dependent deacetylase sirtuin 1 (SIRT1) and SIRT2 inhibited the progrowth action of Nampt-NAD axis, whereas knockdown of SIRT1, SIRT2, and SIRT6 compromised the prodifferentiation effect of Nampt-NAD axis.	NAD	107-110	sirtuin 2	Mus musculus	61-66
26060246-10	2015	Knockdown of NAD-dependent deacetylase sirtuin 1 (SIRT1) and SIRT2 inhibited the progrowth action of Nampt-NAD axis, whereas knockdown of SIRT1, SIRT2, and SIRT6 compromised the prodifferentiation effect of Nampt-NAD axis.	NAD	107-110	sirtuin 2	Mus musculus	145-150
24946089-6	2014	At variance with other sirtuin modulators (sirtinol, AGK2 and SRT1720), the well-known SIRT1 inhibitor Ex527 has positive effects on survival of neuronal cells expressing mutant SOD1, but this effect is neither mediated by SIRT1 inhibition nor by SIRT2 inhibition.	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	103-108	sirtuin 2	Mus musculus	247-252
24963697-0	2015	Sodium butyrate, a histone deacetylase Inhibitor, ameliorates SIRT2-induced memory impairment, reduction of cell proliferation, and neuroblast differentiation in the dentate gyrus.	Butyric Acid	0-15	sirtuin 2	Mus musculus	62-67
24963697-10	2015	However, the administration of sodium butyrate significantly ameliorated the SIRT2-induced reduction in cell proliferation and neuroblast differentiation.	Butyric Acid	31-46	sirtuin 2	Mus musculus	77-82
24833701-5	2014	Treatment with a SIRT2 inhibitor, AGK2 (2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide), also dose- and time-dependently inhibited renal fibroblast activation and, to a lesser extent, cell proliferation.	AGK2	40-113	sirtuin 2	Mus musculus	17-22
25561724-13	2015	During glucose tolerance tests, glucose disposal was enhanced in SIRT2 knock-out mice, compared with wild type controls, without any effect on insulin concentrations.	Glucose	7-14	sirtuin 2	Mus musculus	65-70
25561724-13	2015	During glucose tolerance tests, glucose disposal was enhanced in SIRT2 knock-out mice, compared with wild type controls, without any effect on insulin concentrations.	Glucose	32-39	sirtuin 2	Mus musculus	65-70
25672834-9	2015	Conversely, overexpression of SIRT2 by the intra-hippocampal infusion of recombinant adenovirus vector expressing mouse SIRT2 reversed the CUS-induced depressive-like behaviors, and promoted neurogenesis.	cus	139-142	sirtuin 2	Mus musculus	30-35
25672834-9	2015	Conversely, overexpression of SIRT2 by the intra-hippocampal infusion of recombinant adenovirus vector expressing mouse SIRT2 reversed the CUS-induced depressive-like behaviors, and promoted neurogenesis.	cus	139-142	sirtuin 2	Mus musculus	120-125
24793418-3	2014	We have examined the role of SIRT2 in insulin-mediated glucose disposal in normal and insulin resistant C2C12 skeletal muscle cells in vitro.	Glucose	55-62	sirtuin 2	Mus musculus	29-34
24793418-5	2014	Pharmacological inhibition of SIRT2 increased insulin-stimulated glucose uptake and improved phosphorylation of Akt and GSK3beta in insulin resistant cells.	Glucose	65-72	sirtuin 2	Mus musculus	30-35
24866770-9	2014	IMPLICATIONS: Disruption of the SIRT2-beta-catenin interaction represents an endogenous therapeutic target to prevent transformation and preserve the integrity of aging cells against exogenous stressors such as reactive oxygen species.	Reactive Oxygen Species	211-234	sirtuin 2	Mus musculus	32-37
25157229-0	2014	SIRT2 enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via apoptotic pathway.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	15-59	sirtuin 2	Mus musculus	0-5
25157229-0	2014	SIRT2 enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via apoptotic pathway.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	61-65	sirtuin 2	Mus musculus	0-5
25157229-8	2014	We also show that neurodegeneration induced by chronic MPTP regimen is prevented by genetic deletion of SIRT2 in mouse.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	55-59	sirtuin 2	Mus musculus	104-109
25003320-8	2014	Bone marrow derived macrophages isolated from SIRT2 KO mice produced lower nitric oxide and expressed lower levels of M1-macrophage related markers including iNOS and CD86 in response to LPS than WT mice.	Nitric Oxide	75-87	sirtuin 2	Mus musculus	46-51
25003320-9	2014	Decrease of SIRT2 reduced the LPS-induced reactive oxygen species production.	Reactive Oxygen Species	42-65	sirtuin 2	Mus musculus	12-17
25072851-5	2014	RESULTS: Sirt2-/- mice displayed more severe clinical and histological manifestations after DSS colitis compared to wild type littermates.	Dextran Sulfate	92-95	sirtuin 2	Mus musculus	9-14
24825348-5	2014	Here, we show that the loss of BubR1 levels with age is due to a decline in NAD(+) and the ability of SIRT2 to maintain lysine-668 of BubR1 in a deacetylated state, which is counteracted by the acetyltransferase CBP.	Lysine	120-126	sirtuin 2	Mus musculus	102-107
24107942-5	2013	Viral-mediated overexpression of SIRT1 or SIRT2 in the NAc enhances the rewarding effects of both cocaine and morphine.	Cocaine	98-105	sirtuin 2	Mus musculus	42-47
24211200-9	2013	Mechanically, Sirt2 deacetylated p65 subunit of nuclear factor-kappa B (NF-kappaB) at lysine 310, resulting in reduced expression of NF-kappaB-dependent genes, including interleukin 1beta (IL-1beta), IL-6, monocyte chemoattractant protein 1(MCP-1), RANTES, matrix metalloproteinase 9 (MMP-9) and MMP-13.	Lysine	86-92	sirtuin 2	Mus musculus	14-19
24204656-3	2013	Here we demonstrate that Sirt2 is up-regulated during RA (retinoic acid)-induced and embryoid body (EB) differentiation of mouse ESCs.	Tretinoin	54-56	sirtuin 2	Mus musculus	25-30
24204656-3	2013	Here we demonstrate that Sirt2 is up-regulated during RA (retinoic acid)-induced and embryoid body (EB) differentiation of mouse ESCs.	Tretinoin	58-71	sirtuin 2	Mus musculus	25-30
24204656-5	2013	Knockdown of Sirt2 expression also leads to the activation of GSK3beta through decreased phosphorylation of the serine at position 9 (Ser9) but not tyrosine at position 216 (Tyr216).	Serine	112-118	sirtuin 2	Mus musculus	13-18
24013120-6	2013	SIRT2 overexpression inhibited microglia activation in a process dependent on serine 331 (S331) phosphorylation.	Serine	78-84	sirtuin 2	Mus musculus	0-5
24013120-7	2013	Conversely, reduction of SIRT2 in microglia dramatically increased the expression of inflammatory markers, the production of free radicals, and neurotoxicity.	Free Radicals	125-138	sirtuin 2	Mus musculus	25-30
23770196-4	2013	Purified PEP-1-SIRT2 was transduced into RAW 264.7 cells in a time- and dose-dependent manner and protected against lipopolysaccharide- and hydrogen peroxide (H2O2)-induced cell death and cytotoxicity.	Hydrogen Peroxide	140-157	sirtuin 2	Mus musculus	15-20
23770196-4	2013	Purified PEP-1-SIRT2 was transduced into RAW 264.7 cells in a time- and dose-dependent manner and protected against lipopolysaccharide- and hydrogen peroxide (H2O2)-induced cell death and cytotoxicity.	Hydrogen Peroxide	159-163	sirtuin 2	Mus musculus	15-20
23770196-6	2013	In addition, PEP-1-SIRT2 decreased cellular levels of reactive oxygen species (ROS) and of cleaved caspase-3, whereas it elevated the expression of antioxidant enzymes such as MnSOD, catalase, and glutathione peroxidase.	Reactive Oxygen Species	54-77	sirtuin 2	Mus musculus	19-24
23770196-6	2013	In addition, PEP-1-SIRT2 decreased cellular levels of reactive oxygen species (ROS) and of cleaved caspase-3, whereas it elevated the expression of antioxidant enzymes such as MnSOD, catalase, and glutathione peroxidase.	Reactive Oxygen Species	79-82	sirtuin 2	Mus musculus	19-24
23770196-7	2013	Furthermore, topical application of PEP-1-SIRT2 to 12-O-tetradecanoylphorbol 13-acetate-treated mouse ears markedly inhibited expression levels of COX-2 and proinflammatory cytokines as well as the activation of NF-kappaB and MAPKs.	Tetradecanoylphorbol Acetate	51-87	sirtuin 2	Mus musculus	42-47
23770196-8	2013	These results demonstrate that PEP-1-SIRT2 inhibits inflammation and oxidative stress by reducing the levels of expression of cytokines and ROS, suggesting that PEP-1-SIRT2 may be a potential therapeutic agent for various disorders related to ROS, including skin inflammation.	Reactive Oxygen Species	140-143	sirtuin 2	Mus musculus	37-42
23770196-8	2013	These results demonstrate that PEP-1-SIRT2 inhibits inflammation and oxidative stress by reducing the levels of expression of cytokines and ROS, suggesting that PEP-1-SIRT2 may be a potential therapeutic agent for various disorders related to ROS, including skin inflammation.	Reactive Oxygen Species	140-143	sirtuin 2	Mus musculus	167-172
23770196-8	2013	These results demonstrate that PEP-1-SIRT2 inhibits inflammation and oxidative stress by reducing the levels of expression of cytokines and ROS, suggesting that PEP-1-SIRT2 may be a potential therapeutic agent for various disorders related to ROS, including skin inflammation.	Reactive Oxygen Species	243-246	sirtuin 2	Mus musculus	37-42
23770196-8	2013	These results demonstrate that PEP-1-SIRT2 inhibits inflammation and oxidative stress by reducing the levels of expression of cytokines and ROS, suggesting that PEP-1-SIRT2 may be a potential therapeutic agent for various disorders related to ROS, including skin inflammation.	Reactive Oxygen Species	243-246	sirtuin 2	Mus musculus	167-172
24003916-4	2013	NLRP3 inflammasome inducers reduce the NAD(+) level to inactivate the alpha-tubulin deacetylase Sirtuin 2, resulting in accumulation of acetylated alpha-tubulin.	NAD	39-45	sirtuin 2	Mus musculus	96-105
24107942-2	2013	Here, we establish an essential role for SIRT1 and SIRT2 in regulating behavioral responses to cocaine and morphine through actions in the nucleus accumbens (NAc), a key brain reward region.	Cocaine	95-102	sirtuin 2	Mus musculus	51-56
24107942-2	2013	Here, we establish an essential role for SIRT1 and SIRT2 in regulating behavioral responses to cocaine and morphine through actions in the nucleus accumbens (NAc), a key brain reward region.	Morphine	107-115	sirtuin 2	Mus musculus	51-56
24107942-3	2013	We show that chronic cocaine administration increases SIRT1 and SIRT2 expression in the mouse NAc, while chronic morphine administration induces SIRT1 expression alone, with no regulation of all other sirtuin family members observed.	Cocaine	21-28	sirtuin 2	Mus musculus	64-69
23898190-1	2013	Sirtuin 2 (SIRT2) is a sirtuin family deacetylase that directs acetylome signaling, protects genome integrity, and is a murine tumor suppressor.	acetylome	63-72	sirtuin 2	Mus musculus	0-9
23898190-1	2013	Sirtuin 2 (SIRT2) is a sirtuin family deacetylase that directs acetylome signaling, protects genome integrity, and is a murine tumor suppressor.	acetylome	63-72	sirtuin 2	Mus musculus	11-16
23898190-4	2013	SIRT2 interacts with and deacetylates CDK9 at lysine 48 in response to replication stress in a manner that is partially dependent on ataxia telangiectasia and Rad3 related (ATR) but not cyclin T or K, thereby stimulating CDK9 kinase activity and promoting recovery from replication arrest.	Lysine	46-52	sirtuin 2	Mus musculus	0-5
24107942-5	2013	Viral-mediated overexpression of SIRT1 or SIRT2 in the NAc enhances the rewarding effects of both cocaine and morphine.	Morphine	110-118	sirtuin 2	Mus musculus	42-47
21949390-2	2011	We previously used global expression profiling to examine peripheral nerve myelination and identified the NAD(+)-dependent deacetylase Sir-two-homolog 2 (Sirt2) as a protein likely to be involved in myelination.	NAD	106-112	sirtuin 2	Mus musculus	135-152
23908241-3	2013	SIRT2 associates with the transcription start site of a subset of genes repressed during infection and deacetylates histone H3 on lysine 18 (H3K18).	Lysine	130-136	sirtuin 2	Mus musculus	0-5
23570735-0	2013	Poly(ADP-ribose) polymerase mediates both cell death and ATP decreases in SIRT2 inhibitor AGK2-treated microglial BV2 cells.	Adenosine Triphosphate	57-60	sirtuin 2	Mus musculus	74-79
23570735-6	2013	Collectively, our study has provided the first evidence suggesting a significant role of SIRT2 in the basal survival of microglia, as well as a mechanism accounting for the effects of SIRT2 on intracellular ATP levels.	Adenosine Triphosphate	207-210	sirtuin 2	Mus musculus	184-189
23201684-0	2012	The NAD-dependent deacetylase SIRT2 is required for programmed necrosis.	NAD	4-7	sirtuin 2	Mus musculus	30-35
23201684-4	2012	Here, we show that the NAD-dependent deacetylase SIRT2 binds constitutively to RIP3 and that deletion or knockdown of SIRT2 prevents formation of the RIP1-RIP3 complex in mice.	NAD	23-26	sirtuin 2	Mus musculus	49-54
23201684-4	2012	Here, we show that the NAD-dependent deacetylase SIRT2 binds constitutively to RIP3 and that deletion or knockdown of SIRT2 prevents formation of the RIP1-RIP3 complex in mice.	NAD	23-26	sirtuin 2	Mus musculus	118-123
22898818-0	2012	Sirtuin 2 (SIRT2) enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via deacetylating forkhead box O3a (Foxo3a) and activating Bim protein.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	27-71	sirtuin 2	Mus musculus	0-9
22898818-0	2012	Sirtuin 2 (SIRT2) enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via deacetylating forkhead box O3a (Foxo3a) and activating Bim protein.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	27-71	sirtuin 2	Mus musculus	11-16
22898818-0	2012	Sirtuin 2 (SIRT2) enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via deacetylating forkhead box O3a (Foxo3a) and activating Bim protein.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	73-77	sirtuin 2	Mus musculus	0-9
22898818-0	2012	Sirtuin 2 (SIRT2) enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via deacetylating forkhead box O3a (Foxo3a) and activating Bim protein.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	73-77	sirtuin 2	Mus musculus	11-16
22898818-6	2012	We show here that SIRT2 deacetylates Foxo3a, increases RNA and protein levels of Bim, and as a result, enhances apoptosis in the MPTP model of PD.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	129-133	sirtuin 2	Mus musculus	18-23
22898818-7	2012	We also show that neurodegeneration induced by chronic MPTP regimen is prevented by genetic deletion of SIRT2 in mouse.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	55-59	sirtuin 2	Mus musculus	104-109
22898818-9	2012	We demonstrate that SIRT2 deacetylates Foxo3a, activates Bim, and induces apoptosis only in 1-methyl-4-phenylpyridinium-treated cells.	1-Methyl-4-phenylpyridinium	92-119	sirtuin 2	Mus musculus	20-25
22992439-9	2012	Whereas, a significant downregulation in sirt1 and sirt3 and a significant upregulation in sirt2, sirt4, sirt6, and sirt7 were observed in the treatment of TSA.	trichostatin A	156-159	sirtuin 2	Mus musculus	91-96
22416232-0	2012	Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia.	2-sulfobenzoic acid	29-46	sirtuin 2	Mus musculus	14-23
21949390-2	2011	We previously used global expression profiling to examine peripheral nerve myelination and identified the NAD(+)-dependent deacetylase Sir-two-homolog 2 (Sirt2) as a protein likely to be involved in myelination.	NAD	106-112	sirtuin 2	Mus musculus	154-159
17634366-8	2007	Because normal SIRT2 activity is controlled by the NAD+/NADH ratio, its function may be coupled to the axo-glial metabolism and the long-term support of axons by oligodendrocytes.	NAD	51-55	sirtuin 2	Mus musculus	15-20
21370928-0	2011	A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase.	Cholesterol	50-61	sirtuin 2	Mus musculus	88-97
21370928-1	2011	Sirtuin 2 (SIRT2) deacetylase-dependent inhibition mediates neuroprotective reduction of cholesterol biosynthesis in an in vitro Huntington"s disease model.	Cholesterol	89-100	sirtuin 2	Mus musculus	0-9
21370928-1	2011	Sirtuin 2 (SIRT2) deacetylase-dependent inhibition mediates neuroprotective reduction of cholesterol biosynthesis in an in vitro Huntington"s disease model.	Cholesterol	89-100	sirtuin 2	Mus musculus	11-16
21370928-3	2011	Using biochemical sirtuin deacetylation assays, we screened a brain-permeable in silico compound library, yielding 3-(1-azepanylsulfonyl)-N-(3-bromphenyl)benzamide as the most potent and selective SIRT2 inhibitor.	3-(1-azepanylsulfonyl)-N-(3-bromphenyl)benzamide	115-163	sirtuin 2	Mus musculus	197-202
21370928-5	2011	In accordance with previous observations, this SIRT2 inhibitor stimulated cytoplasmic retention of sterol regulatory element binding protein-2 and subsequent transcriptional downregulation of cholesterol biosynthesis genes, resulting in reduced total cholesterol in primary striatal neurons.	Cholesterol	192-203	sirtuin 2	Mus musculus	47-52
21370928-5	2011	In accordance with previous observations, this SIRT2 inhibitor stimulated cytoplasmic retention of sterol regulatory element binding protein-2 and subsequent transcriptional downregulation of cholesterol biosynthesis genes, resulting in reduced total cholesterol in primary striatal neurons.	Cholesterol	251-262	sirtuin 2	Mus musculus	47-52
18987186-6	2008	Nicotinamide also dramatically increased acetylated alpha-tubulin, a primary substrate of SirT2, and MAP2c, both of which are linked to increased microtubule stability.	Niacinamide	0-12	sirtuin 2	Mus musculus	90-95
17560549-0	2007	Resveratrol abolishes resistance to axonal degeneration in slow Wallerian degeneration (WldS) mice: activation of SIRT2, an NAD-dependent tubulin deacetylase.	Resveratrol	0-11	sirtuin 2	Mus musculus	114-119
17560549-0	2007	Resveratrol abolishes resistance to axonal degeneration in slow Wallerian degeneration (WldS) mice: activation of SIRT2, an NAD-dependent tubulin deacetylase.	NAD	124-127	sirtuin 2	Mus musculus	114-119
17560549-5	2007	This promoting effect on tubulin deacetylation was mimicked by NAD, suggesting the involvement of SIRT2, an NAD-dependent tubulin deacetylase.	NAD	63-66	sirtuin 2	Mus musculus	98-103
17560549-5	2007	This promoting effect on tubulin deacetylation was mimicked by NAD, suggesting the involvement of SIRT2, an NAD-dependent tubulin deacetylase.	NAD	108-111	sirtuin 2	Mus musculus	98-103
17560549-6	2007	Indeed, resveratrol promoted tubulin deacetylation in the presence of GFP-SIRT2 but not GFP-SIRT2 N168A, a catalytically inactive mutant.	Resveratrol	8-19	sirtuin 2	Mus musculus	74-79
17560549-7	2007	Moreover, SIRT2 silencing restored the resistance to axonal degeneration in resveratrol-treated Wld(S) neurons.	Resveratrol	76-87	sirtuin 2	Mus musculus	10-15
17560549-8	2007	These results suggest that resveratrol abolishes the resistance of Wld(S) mice to axonal degeneration by enhancing SIRT2-mediated tubulin deacetylation.	Resveratrol	27-38	sirtuin 2	Mus musculus	115-120
17765928-10	2007	Inhibition of Sirt2 using splitomicin impaired cardiomyocyte contractile function (reduced PS, +/-dL/dt, prolonged TPS and TR(90)).	splitomicin	26-37	sirtuin 2	Mus musculus	14-19
17634366-8	2007	Because normal SIRT2 activity is controlled by the NAD+/NADH ratio, its function may be coupled to the axo-glial metabolism and the long-term support of axons by oligodendrocytes.	NAD	56-60	sirtuin 2	Mus musculus	15-20
14523559-10	2003	Using a chromatin immunoprecipitation technique, we showed that the upregulation of SIRT2 expression with TSA is related to the hyperacetylation of DNA-bound histone H4 within the first 500 bp upstream of the transcription start site of the SIRT2 gene.	trichostatin A	106-109	sirtuin 2	Mus musculus	84-89
14523559-10	2003	Using a chromatin immunoprecipitation technique, we showed that the upregulation of SIRT2 expression with TSA is related to the hyperacetylation of DNA-bound histone H4 within the first 500 bp upstream of the transcription start site of the SIRT2 gene.	trichostatin A	106-109	sirtuin 2	Mus musculus	241-246
33810233-12	2021	Thus, we report impaired autophagosome formation and autophagy clearance via increased SIRT2 expression in FFA-exposed tolerant macrophages.	Flufenamic Acid	107-110	sirtuin 2	Mus musculus	87-92
34597608-6	2021	KEY FINDINGS: Although the SIRT2-/- mice were viable, their livers exhibited higher glycogen accumulation, and skeletal muscle showed features of increased metabolic demand.	Glycogen	84-92	sirtuin 2	Mus musculus	27-32
34506725-2	2021	Here, we elucidate a transcellular signaling mechanism by which oligodendrocytes support axonal energy metabolism via transcellular delivery of NAD-dependent deacetylase SIRT2.	NAD	144-147	sirtuin 2	Mus musculus	170-175
34506725-7	2021	Thus, our study reveals an oligodendrocyte-to-axon delivery of SIRT2, which enhances ATP production by deacetylating mitochondrial proteins, providing a target for boosting axonal bioenergetic metabolism in neurological disorders.	Adenosine Triphosphate	85-88	sirtuin 2	Mus musculus	63-68
34139124-5	2021	Here, we have developed a pan SIRT1-3 inhibitor (NH4-6) and a SIRT2-selective inhibitor (NH4-13) with very similar chemical structures, with the only difference being the substitution of an ester bond to an amide bond.	nh4-13	89-95	sirtuin 2	Mus musculus	62-67
34555594-6	2021	SIRT2 interacted with PARP1 at the PARP-A-helical domain and deacetylated the K249 residue of PARP1.	2-Bromo-5-iodopyridine	78-82	sirtuin 2	Mus musculus	0-5
34555594-7	2021	Furthermore, SIRT2 promoted ubiquitination of the K249 residue of PARP1 via mobilization of the E3 ubiquitin ligase WW domain-containing protein 2 (WWP2), which led to proteasome-mediated degradation of PARP1.	2-Bromo-5-iodopyridine	50-54	sirtuin 2	Mus musculus	13-18
34183378-0	2021	Silybin restored CYP3A expression through the SIRT2/NF-kappaB pathway in mouse nonalcoholic fatty liver disease.	Silybin	0-7	sirtuin 2	Mus musculus	46-51
34183378-4	2021	Moreover, silybin suppressed liver inflammation in HFD-fed mice and inhibited NF-kappaB translocation into the nucleus through elevation of SIRT2 expression and promotion of p65 deacetylation.	Silybin	10-17	sirtuin 2	Mus musculus	140-145
34183378-10	2021	In summary, silybin increased NAD+ concentration, promoted SIRT2 expression and lowered p65 acetylation both in vivo and in vitro, which supported the recovery of CYP3A expression.	Silybin	12-19	sirtuin 2	Mus musculus	59-64
34183378-11	2021	These findings indicate that the NAD+/SIRT2 pathway plays an important role in CYP3A regulation during NAFLD.	NAD	33-37	sirtuin 2	Mus musculus	38-43
34183378-13	2021	In the treatment of NAFLD, silybin restored, not inhibited, CYP3A expression and activity through the NAD+/SIRT2 pathway in accordance with its anti-inflammatory effect.	Silybin	27-34	sirtuin 2	Mus musculus	107-112
34175423-3	2021	The transcriptional factor cAMP response element binding protein (CREB), and deacetylases isozymes sirtuins 1 and 2 (SIRT-1 and SIRT-2) have a complex interplay and both play a role in the rewarding effects of ethanol.	Ethanol	210-217	sirtuin 2	Mus musculus	128-134
34139124-5	2021	Here, we have developed a pan SIRT1-3 inhibitor (NH4-6) and a SIRT2-selective inhibitor (NH4-13) with very similar chemical structures, with the only difference being the substitution of an ester bond to an amide bond.	Esters	190-195	sirtuin 2	Mus musculus	62-67
34139124-5	2021	Here, we have developed a pan SIRT1-3 inhibitor (NH4-6) and a SIRT2-selective inhibitor (NH4-13) with very similar chemical structures, with the only difference being the substitution of an ester bond to an amide bond.	Amides	207-212	sirtuin 2	Mus musculus	62-67
33574568-0	2021	SL010110, a lead compound, inhibits gluconeogenesis via SIRT2-p300-mediated PEPCK1 degradation and improves glucose homeostasis in diabetic mice.	sl010110	0-8	sirtuin 2	Mus musculus	56-61
35488871-0	2022	Bombesin receptor-activated protein exacerbates cisplatin-induced AKI by regulating the degradation of SIRT2.	Cisplatin	48-57	sirtuin 2	Mus musculus	103-108
35488871-14	2022	Next, we found that SIRT2 was downregulated in cisplatin-induced AKI, and BRAP levels directly impacted the protein levels of SIRT2.	Cisplatin	47-56	sirtuin 2	Mus musculus	20-25
35488871-14	2022	Next, we found that SIRT2 was downregulated in cisplatin-induced AKI, and BRAP levels directly impacted the protein levels of SIRT2.	Cisplatin	47-56	sirtuin 2	Mus musculus	126-131
35574497-11	2022	Mice were injected with EX-527, a selective SIRT1 inhibitor; SirReal2, selective SIRT2 inhibitor or salermide, a nonspecific inhibitor of SIRT1 and SIRT2.	N-(3-((2-hydroxynaphthalen-1-ylmethylene)amino)phenyl)-2-phenylpropionamide	100-109	sirtuin 2	Mus musculus	148-153
35264567-4	2022	When we supplement beta-nicotinamide mononucleotide (beta-NMN), an NAD+ precursor, nuclear entry of SIRT2 in OPCs, OPC differentiation, and remyelination were rescued in aged animals.	neuromedin N-125	19-51	sirtuin 2	Mus musculus	100-105
35264567-4	2022	When we supplement beta-nicotinamide mononucleotide (beta-NMN), an NAD+ precursor, nuclear entry of SIRT2 in OPCs, OPC differentiation, and remyelination were rescued in aged animals.	neuromedin N-125	53-61	sirtuin 2	Mus musculus	100-105
35264567-4	2022	When we supplement beta-nicotinamide mononucleotide (beta-NMN), an NAD+ precursor, nuclear entry of SIRT2 in OPCs, OPC differentiation, and remyelination were rescued in aged animals.	NAD	67-71	sirtuin 2	Mus musculus	100-105
35264567-5	2022	We show that the effects on myelination are mediated via the NAD+-SIRT2-H3K18Ac-ID4 axis, and SIRT2 is required for rejuvenating OPCs.	NAD	61-65	sirtuin 2	Mus musculus	66-71
33028985-7	2021	Consequently, Tan-IIA reduced glycolysis and protected the activity of Sirtuin2 (Sirt2), an NAD+-dependent protein deacetylase, by raising the ratio of NAD+/NADH in activated macrophages.	tanshinone	14-21	sirtuin 2	Mus musculus	71-79
33028985-7	2021	Consequently, Tan-IIA reduced glycolysis and protected the activity of Sirtuin2 (Sirt2), an NAD+-dependent protein deacetylase, by raising the ratio of NAD+/NADH in activated macrophages.	tanshinone	14-21	sirtuin 2	Mus musculus	81-86
33028985-7	2021	Consequently, Tan-IIA reduced glycolysis and protected the activity of Sirtuin2 (Sirt2), an NAD+-dependent protein deacetylase, by raising the ratio of NAD+/NADH in activated macrophages.	NAD	92-96	sirtuin 2	Mus musculus	71-79
33028985-7	2021	Consequently, Tan-IIA reduced glycolysis and protected the activity of Sirtuin2 (Sirt2), an NAD+-dependent protein deacetylase, by raising the ratio of NAD+/NADH in activated macrophages.	NAD	92-96	sirtuin 2	Mus musculus	81-86
33028985-7	2021	Consequently, Tan-IIA reduced glycolysis and protected the activity of Sirtuin2 (Sirt2), an NAD+-dependent protein deacetylase, by raising the ratio of NAD+/NADH in activated macrophages.	NAD	157-161	sirtuin 2	Mus musculus	71-79
33028985-7	2021	Consequently, Tan-IIA reduced glycolysis and protected the activity of Sirtuin2 (Sirt2), an NAD+-dependent protein deacetylase, by raising the ratio of NAD+/NADH in activated macrophages.	NAD	157-161	sirtuin 2	Mus musculus	81-86
34059674-4	2021	The acetyltransferase MYST1 stimulated by Acetyl-CoA, and the deacetylase SIRT2 stimulated by NAD +, are identified as direct regulators of PAX7 acetylation and asymmetric division in muscle stem cells.	NAD	94-99	sirtuin 2	Mus musculus	74-79
33636024-3	2021	This study further revealed that SIRT2 was markedly decreased in obese mice and in palmitate-treated HepG2 cells.	Palmitates	83-92	sirtuin 2	Mus musculus	33-38
33636024-5	2021	Mechanistically, SIRT2 stabilized the hepatocyte nuclear factor 4alpha (HNF4alpha) protein by binding to and deacetylating HNF4alpha on lysine 458.	Lysine	136-142	sirtuin 2	Mus musculus	17-22
33754067-14	2021	Treatment of AGK2, a selective inhibitor of SIRT2, blocked the therapeutic action of NR against NAFLD pathologies and NR-induced Fndc5 deubiquitination/deacetylation.	nicotinamide-beta-riboside	85-87	sirtuin 2	Mus musculus	44-49
33754067-15	2021	At last, we identified that the lysine sites K127/131 and K185/187/189 of Fndc5 may contribute to the SIRT2-dependent deacetylation and deubiquitination of Fndc5.	Lysine	32-38	sirtuin 2	Mus musculus	102-107
33754067-16	2021	Conclusions: The findings from this research for the first time demonstrate that NAD+-boosting therapy reverses NAFLD by regulating SIRT2-deppendent Fndc5 deacetylation and deubiquitination, which results in a stimulation of Fndc5/irisin, a novel exerkine.	NAD	81-85	sirtuin 2	Mus musculus	132-137
33574568-12	2021	This study reveals that SL010110 is a lead compound with a distinct mechanism of suppressing gluconeogenesis via SIRT2-p300-mediated PEPCK1 degradation and potent anti-hyperglycemic activity for the treatment of T2D.	sl010110	24-32	sirtuin 2	Mus musculus	113-118
33368409-0	2021	Ethanol Exposure Attenuates Immune Response in Sepsis via Sirtuin 2 Expression.	Ethanol	0-7	sirtuin 2	Mus musculus	58-67
33368409-20	2021	Ethanol-exposed SIRT2KO-sepsis mice showed greater 7-day survival, LA, and bacterial clearance than WT ethanol-sepsis mice.	Ethanol	0-7	sirtuin 2	Mus musculus	16-23
33368409-20	2021	Ethanol-exposed SIRT2KO-sepsis mice showed greater 7-day survival, LA, and bacterial clearance than WT ethanol-sepsis mice.	Ethanol	103-110	sirtuin 2	Mus musculus	16-23
34155309-1	2021	SIRT2, an NAD+-dependent histone deacetylase, has been shown to play a pivotal role in various physiological processes, however, its role in cancer is currently controversial.	NAD	10-13	sirtuin 2	Mus musculus	0-5
35493297-6	2022	Results: The expression level of SIRT2 was remarkably upregulated in the high-GLU group in contrast to the low-GLU group.	Glutamic Acid	78-81	sirtuin 2	Mus musculus	33-38
35493297-6	2022	Results: The expression level of SIRT2 was remarkably upregulated in the high-GLU group in contrast to the low-GLU group.	Glutamic Acid	111-114	sirtuin 2	Mus musculus	33-38
35493297-9	2022	Chloroquine influenced cell proliferation and apoptosis in cells targeted with SIRT2 siRNA.	Chloroquine	0-11	sirtuin 2	Mus musculus	79-84
35443760-2	2022	Although several studies based on the MPTP model of PD show that SIRT2 deletion can protect against dopaminergic neuron loss, the precise mechanisms of SIRT2-mediated neuronal death have largely remained unknown.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	38-42	sirtuin 2	Mus musculus	65-70
35066290-10	2022	CBP/SIRT2 interacted with BAG3 and acetylated/deacetylated BAG3"s K431 residue.	N-ETHYL-P-TOLUENESULFONAMIDE	66-70	sirtuin 2	Mus musculus	4-9
33143523-7	2021	In addition, nicotinamide enhanced the RUNX2 protein level and transacting activity posttranslationally with Sirt2 inhibition.	Niacinamide	13-25	sirtuin 2	Mus musculus	109-114
33574568-8	2021	SL010110 decreased NAD+/NADH ratio, inhibited SIRT2 activity, and further promoted p300 acetyltransferase activation and PEPCK1 acetylation.	sl010110	0-8	sirtuin 2	Mus musculus	46-51
33574568-9	2021	These effects were blocked by NMN, an NAD+ precursor, suggested that SL010110 inhibited gluconeogenesis by inhibiting SIRT2, activating p300, and subsequently promoting PEPCK1 acetylation.	sl010110	69-77	sirtuin 2	Mus musculus	118-123
33574568-10	2021	In type 2 diabetic ob/ob mice, single oral dose of SL010110 (100 mg/kg) suppressed gluconeogenesis accompanied by the suppressed hepatic SIRT2 activity, increased p300 activity, enhanced PEPCK1 acetylation and degradation.	sl010110	51-59	sirtuin 2	Mus musculus	137-142
33481678-0	2021	Role of SIRT2 in regulating the dexamethasone-activated autophagy pathway in skeletal muscle atrophy.	Dexamethasone	32-45	sirtuin 2	Mus musculus	8-13
33368409-21	2021	CONCLUSION: Ethanol exposure decreases survival and reduces the inflammatory response to sepsis via increased SIRT2 expression.	Ethanol	12-19	sirtuin 2	Mus musculus	110-115
33368409-22	2021	SIRT2 is a potential therapeutic target in ethanol with sepsis.	Ethanol	43-50	sirtuin 2	Mus musculus	0-5
32679047-5	2021	Sirt2 KO mice and WT littermates had psoriatic dermatitis induced by topical treatment of imiquimod or intradermal injection of recombinant IL-23.	Imiquimod	90-99	sirtuin 2	Mus musculus	0-5
33310666-0	2021	Thiomyristoyl ameliorates colitis by blocking the differentiation of Th17 cells and inhibiting SIRT2-induced metabolic reprogramming.	Thiomyristoyl	0-13	sirtuin 2	Mus musculus	95-100
33481678-3	2021	We aimed to determine the effects of SIRT2 on autophagy in Dex-induced myoatrophy.	Dexamethasone	59-62	sirtuin 2	Mus musculus	37-42
33481678-10	2021	Conversely, SIRT2 overexpression alleviated Dex-induced myoatrophy in vitro.	Dexamethasone	44-47	sirtuin 2	Mus musculus	12-17
33481678-12	2021	These findings suggested that SIRT2 activation protects myotubes against Dex-induced atrophy through the inhibition of the autophagy system; this phenomenon may potentially serve as a target for treating glucocorticoid-induced myopathy.	Dexamethasone	73-76	sirtuin 2	Mus musculus	30-35
32700357-0	2020	RTN4B-mediated suppression of Sirtuin 2 activity ameliorates beta-amyloid pathology and cognitive impairment in Alzheimer"s disease mouse model.	rtn4b	0-5	sirtuin 2	Mus musculus	30-39
32700357-1	2020	Sirtuin 2 (SIRT2) is an NAD+ dependent deacetylase that is the most abundant sirtuin protein in the brain.	NAD	24-27	sirtuin 2	Mus musculus	0-9
32700357-1	2020	Sirtuin 2 (SIRT2) is an NAD+ dependent deacetylase that is the most abundant sirtuin protein in the brain.	NAD	24-27	sirtuin 2	Mus musculus	11-16
32697192-2	2020	Here, we show that Mtb upregulates one of the key epigenetic modulators, NAD+ dependent histone deacetylase Sirtuin 2 (SIRT2), which upon infection translocate to the nucleus and deacetylates histone H3K18, thus modulating the host transcriptome leading to enhanced macrophage activation.	NAD	73-76	sirtuin 2	Mus musculus	119-124
32697192-4	2020	Pharmacological inhibition of SIRT2 restricts the intracellular growth of both drug-sensitive and resistant strains of Mtb and enhances the efficacy of front line anti-TB drug Isoniazid in the murine model of infection.	Isoniazid	176-185	sirtuin 2	Mus musculus	30-35
32240312-0	2020	SIRT2 is involved in cisplatin-induced acute kidney injury through regulation of mitogen-activated protein kinase phosphatase-1.	Cisplatin	21-30	sirtuin 2	Mus musculus	0-5
32240312-7	2020	Cisplatin-induced downregulation of MKP-1 was reversed in Sirt2 KO mice kidney and further decreased in Sirt2 TG mice kidney.	Cisplatin	0-9	sirtuin 2	Mus musculus	58-63
32240312-7	2020	Cisplatin-induced downregulation of MKP-1 was reversed in Sirt2 KO mice kidney and further decreased in Sirt2 TG mice kidney.	Cisplatin	0-9	sirtuin 2	Mus musculus	104-109
32240312-10	2020	A decrease in SIRT2 suppressed cisplatin-induced phosphorylation of p38 and JNK in kidney and tubular epithelial cells.	Cisplatin	31-40	sirtuin 2	Mus musculus	14-19
32240312-12	2020	Acetylation of MKP-1 was significantly increased in SIRT2-knockdown cells and decreased in SIRT2-overexpressed cells after cisplatin stimulation.	Cisplatin	123-132	sirtuin 2	Mus musculus	91-96
32240312-13	2020	Sirt2 KO mice and Sirt2 TG mice showed amelioration and aggravation of renal injury, apoptosis, necroptosis and inflammation induced by cisplatin.	Cisplatin	136-145	sirtuin 2	Mus musculus	0-5
32240312-13	2020	Sirt2 KO mice and Sirt2 TG mice showed amelioration and aggravation of renal injury, apoptosis, necroptosis and inflammation induced by cisplatin.	Cisplatin	136-145	sirtuin 2	Mus musculus	18-23
32240312-14	2020	CONCLUSION: Our data show that SIRT2 is associated with cisplatin-induced renal injury through regulation of MKP-1 expression.	Cisplatin	56-65	sirtuin 2	Mus musculus	31-36
32625056-6	2020	These results indicate that microglial Sirt2 prevents NMDA-mediated excitotoxicity in hippocampal slices in response to an inflammatory signal such as LPS.	N-Methylaspartate	54-58	sirtuin 2	Mus musculus	39-44
32134743-0	2020	SIRT2 protects peripheral neurons from cisplatin-induced injury by enhancing nucleotide excision repair.	Cisplatin	39-48	sirtuin 2	Mus musculus	0-5
32134743-3	2020	Here, we demonstrate that SIRT2 protected mice against cisplatin-induced peripheral neuropathy (CIPN).	Cisplatin	55-64	sirtuin 2	Mus musculus	26-31
32134743-4	2020	SIRT2 accumulated in the nuclei of dorsal root ganglion sensory neurons and prevented neuronal cell death following cisplatin treatment.	Cisplatin	116-125	sirtuin 2	Mus musculus	0-5
32134743-5	2020	Mechanistically, SIRT2, an NAD+-dependent deacetylase, protected neurons from cisplatin cytotoxicity by promoting transcription-coupled nucleotide excision repair (TC-NER) of cisplatin-induced DNA crosslinks.	Cisplatin	78-87	sirtuin 2	Mus musculus	17-22
32134743-5	2020	Mechanistically, SIRT2, an NAD+-dependent deacetylase, protected neurons from cisplatin cytotoxicity by promoting transcription-coupled nucleotide excision repair (TC-NER) of cisplatin-induced DNA crosslinks.	Cisplatin	175-184	sirtuin 2	Mus musculus	17-22
32134743-6	2020	Consistent with this mechanism, pharmacological inhibition of NER using spironolactone abolished SIRT2-mediated TC-NER activity in differentiated neuronal cells and protection of neurons from cisplatin-induced cytotoxicity and CIPN in mice.	Spironolactone	72-86	sirtuin 2	Mus musculus	97-102
32134743-6	2020	Consistent with this mechanism, pharmacological inhibition of NER using spironolactone abolished SIRT2-mediated TC-NER activity in differentiated neuronal cells and protection of neurons from cisplatin-induced cytotoxicity and CIPN in mice.	Cisplatin	192-201	sirtuin 2	Mus musculus	97-102
32134743-6	2020	Consistent with this mechanism, pharmacological inhibition of NER using spironolactone abolished SIRT2-mediated TC-NER activity in differentiated neuronal cells and protection of neurons from cisplatin-induced cytotoxicity and CIPN in mice.	cipn	227-231	sirtuin 2	Mus musculus	97-102
32278117-3	2020	This study aims to identify changes of specific components of NAD+/SIRTs system in white adipose tissue (WAT) and brown adipose tissue (BAT) of mice upon energy imbalance, focusing on key enzymes in NAD+ salvage (Nampt, Nmnat1, Nrk1), clearance (Nnmt, Aox1, Cyp2e1) and consumption pathways (Sirt1, Sirt2, Sirt3, Sirt6, Parp1).	NAD	62-66	sirtuin 2	Mus musculus	299-304
32278117-3	2020	This study aims to identify changes of specific components of NAD+/SIRTs system in white adipose tissue (WAT) and brown adipose tissue (BAT) of mice upon energy imbalance, focusing on key enzymes in NAD+ salvage (Nampt, Nmnat1, Nrk1), clearance (Nnmt, Aox1, Cyp2e1) and consumption pathways (Sirt1, Sirt2, Sirt3, Sirt6, Parp1).	NAD	199-203	sirtuin 2	Mus musculus	299-304
32063085-0	2020	AK-1, a Sirt2 inhibitor, alleviates carbon tetrachloride-induced hepatotoxicity in vivo and in vitro.	Carbon Tetrachloride	36-56	sirtuin 2	Mus musculus	8-13
32063085-2	2020	Sirtuin2 (Sirt2), an NAD+-dependent deacetylase, appears to play detrimental roles in liver injury.	NAD	21-24	sirtuin 2	Mus musculus	0-8
32063085-2	2020	Sirtuin2 (Sirt2), an NAD+-dependent deacetylase, appears to play detrimental roles in liver injury.	NAD	21-24	sirtuin 2	Mus musculus	10-15
32063085-3	2020	Here, we evaluated the therapeutic application targeting Sirt2 in carbon tetrachloride (CCl4)-induced ALI, by using AK-1 (a Sirt2 inhibitor).Methods: For in vivo experiments, a single injection of CCl4 was used to induce ALI.	Carbon Tetrachloride	66-86	sirtuin 2	Mus musculus	57-62