PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 33990437-8 2021 PSB reduced postoperative inflammatory response by limiting concentrations of proinflammatory cytokines IL-8, IL-18, IL-23, IL-33 and MCP-1 measured in the first 7-day after surgery (p<0.05). psb 0-3 interleukin 18 Homo sapiens 110-115 32968210-9 2021 Cultured human and mouse podocytes were treated with high glucose (30 mM), which significantly increased the expression levels of caspase-11 or caspase-4 (the homolog of caspase-11 in human), GSDMD-N, NF-kappaB, IL-1beta, and IL-18, and decreased the expression of nephrin and podocin. Glucose 58-65 interleukin 18 Homo sapiens 226-231 34000515-0 2021 SIRT1-autophagy axis inhibits excess iron-induced ferroptosis of foam cells and subsequently increases IL-1Beta and IL-18. Iron 37-41 interleukin 18 Homo sapiens 116-121 33886081-4 2021 Western blotting, qRT-PCR and ELISA also showed that chloroquine (CQ) could up-regulate the expression of p62 through impairing autophagy and induce the pyroptosis of macrophages treated by ox-LDL, as evidenced by the decrease of cell viability and membrane integrity, and the increase of pro-caspase-1, GSDMD, and proinflammatory factors IL-1beta and IL-18. Chloroquine 53-64 interleukin 18 Homo sapiens 352-357 34055402-0 2021 Interleukin-18 in Brazilian Rheumatoid Arthritis Patients: Can Leflunomide Reduce It? Leflunomide 63-74 interleukin 18 Homo sapiens 0-14 34055402-11 2021 It was observed that patients using leflunomide had the lowest IL-18 levels, close to controls levels (p = 0.0064). Leflunomide 36-47 interleukin 18 Homo sapiens 63-68 34055402-13 2021 IL-18 is at lower levels in those AR who are taking leflunomide as treatment. Leflunomide 52-63 interleukin 18 Homo sapiens 0-5 33790994-7 2021 In addition, Vita Deyun treatment markedly decreased interleukin-18 mRNA levels. vita deyun 13-23 interleukin 18 Homo sapiens 53-67 33790996-7 2021 Sodium barbiturate, ketamine and propofol also decreased the expression levels of the NF-kappaB downstream cytokines, including IL-1beta and IL-18. barbituric acid 0-18 interleukin 18 Homo sapiens 141-146 33790996-7 2021 Sodium barbiturate, ketamine and propofol also decreased the expression levels of the NF-kappaB downstream cytokines, including IL-1beta and IL-18. Ketamine 20-28 interleukin 18 Homo sapiens 141-146 33790996-7 2021 Sodium barbiturate, ketamine and propofol also decreased the expression levels of the NF-kappaB downstream cytokines, including IL-1beta and IL-18. Propofol 33-41 interleukin 18 Homo sapiens 141-146 33886081-4 2021 Western blotting, qRT-PCR and ELISA also showed that chloroquine (CQ) could up-regulate the expression of p62 through impairing autophagy and induce the pyroptosis of macrophages treated by ox-LDL, as evidenced by the decrease of cell viability and membrane integrity, and the increase of pro-caspase-1, GSDMD, and proinflammatory factors IL-1beta and IL-18. Chloroquine 66-68 interleukin 18 Homo sapiens 352-357 33919154-8 2021 Functionally, neutrophils from SLE patients showed higher IL-18-mediated enhancement in reactive oxygen species (ROS) generation, which showed positive correlation with IL18RAP expression and could be neutralized by anti-IL18RAP blocking antibodies. Reactive Oxygen Species 88-111 interleukin 18 Homo sapiens 58-63 33919154-8 2021 Functionally, neutrophils from SLE patients showed higher IL-18-mediated enhancement in reactive oxygen species (ROS) generation, which showed positive correlation with IL18RAP expression and could be neutralized by anti-IL18RAP blocking antibodies. Reactive Oxygen Species 113-116 interleukin 18 Homo sapiens 58-63 33936102-9 2021 Importantly, caproic acid diminished the production of IL-32, IL-18, and IL-1beta in human PBMCs in response to bacterial LPS stimulation. hexanoic acid 13-25 interleukin 18 Homo sapiens 62-67 33861800-6 2021 Using a combination of siRNA knockdowns in monocyte derived macrophages (MDMs) of different TLRs and NLRs as well as chemical inhibition, it was demonstrated that HIV Vpu could trigger inflammasome activation via TLR4/NLRP3 leading to IL-1beta/IL-18 secretion. VPU 167-170 interleukin 18 Homo sapiens 244-249 33857535-10 2021 RESULTS: From ten biomarkers, EFA generated four factors reflecting tubule injury/repair (NGAL, IL-18 and YKL-40), tubule injury/fibrosis (KIM-1 and MCP-1), tubule reabsorption (alpha1m and beta2m), and tubule reserve/mineral metabolism (UMOD, FGF23, and PTH). efa 30-33 interleukin 18 Homo sapiens 96-101 33823789-11 2021 Expression of the inflammatory cytokines IL-1beta, IL-18 and TNF-alpha was significantly increased in cardiac fibroblasts after H/R and was attenuated by dexmedetomidine treatment. Dexmedetomidine 154-169 interleukin 18 Homo sapiens 51-56 33898438-4 2021 We found that prednisolone treatment reduced hESF cytokine expression (IL6, IL11, IL18, LIF, and LIFR) but had no effect on hESF expression or secretion of the classic markers of decidualization [prolactin (PRL) and IGFBP1]. Prednisolone 14-26 interleukin 18 Homo sapiens 82-86 33568399-6 2021 The PTK inhibitors DCC-2036 (Rebastinib) and GZD824, specific for Bcr-Abl kinase, showed the most severe reduction of IL-18 and lactate dehydrogenase release at all concentrations used. olverembatinib 45-51 interleukin 18 Homo sapiens 118-123 33492610-8 2021 In this article we critically reviewed and discussed the central role of the NLRP3 inflammasome in mtDAMP-induced sterile inflammation in atherosclerosis with specific components including caspase-1, pregnane X receptor (PXR), adenosine monophosphate activated protein kinase (AMPK), protein phosphatase 2A (PP2A), thioredoxin-interacting protein (TXNIP), and downstream cytokines including IL-1beta and IL-18 as potential mediators of atherosclerosis. mtdamp 99-105 interleukin 18 Homo sapiens 404-409 33568399-6 2021 The PTK inhibitors DCC-2036 (Rebastinib) and GZD824, specific for Bcr-Abl kinase, showed the most severe reduction of IL-18 and lactate dehydrogenase release at all concentrations used. DCC-2036 19-27 interleukin 18 Homo sapiens 118-123 33433347-5 2021 Simultaneously, Mo or/and Cd upregulated ASC, NLRP3, NEK7, Caspase-1, GSDMA, GSDME, IL-18 and IL-1beta mRNA levels and Caspase-1 p20, NLRP3, ASC, GSDMD protein levels, increased the percentage of pyroptotic cells, LDH, NO, IL-18 and IL-1beta releases as well as relative conductivity. Cadmium 26-28 interleukin 18 Homo sapiens 84-89 33568399-6 2021 The PTK inhibitors DCC-2036 (Rebastinib) and GZD824, specific for Bcr-Abl kinase, showed the most severe reduction of IL-18 and lactate dehydrogenase release at all concentrations used. rebastinib 29-39 interleukin 18 Homo sapiens 118-123 33747105-13 2021 It was found that GLGZG could inhibit OGD/R-induced cell apoptosis, increase neuronal cell viability, decrease the production of IL-18 and IL-1beta, and downregulate the expression levels of pyroptosis markers (NLRP3, ASC, and caspase-1). glgzg 18-23 interleukin 18 Homo sapiens 129-134 33684160-0 2021 A pilot study evaluating GSK1070806 inhibition of interleukin-18 in renal transplant delayed graft function. GSK peptide 25-35 interleukin 18 Homo sapiens 50-64 33684160-4 2021 GSK1070806, an anti-IL18 monoclonal antibody, neutralizes activated (mature) IL18 released from damaged cells following inflammasome activation. GSK peptide 0-10 interleukin 18 Homo sapiens 20-24 33684160-4 2021 GSK1070806, an anti-IL18 monoclonal antibody, neutralizes activated (mature) IL18 released from damaged cells following inflammasome activation. GSK peptide 0-10 interleukin 18 Homo sapiens 77-81 33684160-10 2021 RESULTS: GSK1070806 administration was associated with IL18-GSK1070806 complex detection and increased total serum IL18 levels due to IL18 half-life prolongation induced by GSK1070806 binding. GSK peptide 9-19 interleukin 18 Homo sapiens 55-59 33684160-10 2021 RESULTS: GSK1070806 administration was associated with IL18-GSK1070806 complex detection and increased total serum IL18 levels due to IL18 half-life prolongation induced by GSK1070806 binding. GSK peptide 9-19 interleukin 18 Homo sapiens 115-119 33684160-10 2021 RESULTS: GSK1070806 administration was associated with IL18-GSK1070806 complex detection and increased total serum IL18 levels due to IL18 half-life prolongation induced by GSK1070806 binding. GSK peptide 9-19 interleukin 18 Homo sapiens 115-119 33684160-10 2021 RESULTS: GSK1070806 administration was associated with IL18-GSK1070806 complex detection and increased total serum IL18 levels due to IL18 half-life prolongation induced by GSK1070806 binding. GSK peptide 60-70 interleukin 18 Homo sapiens 55-59 33684160-10 2021 RESULTS: GSK1070806 administration was associated with IL18-GSK1070806 complex detection and increased total serum IL18 levels due to IL18 half-life prolongation induced by GSK1070806 binding. GSK peptide 60-70 interleukin 18 Homo sapiens 55-59 33181835-6 2021 Patients with SCD and either myocardial fibrosis or increased QTc displayed greater IL18 gene expression in peripheral blood mononuclear cells (PBMC), with QTc strongly correlated with plasma IL-18 levels. qtc 62-65 interleukin 18 Homo sapiens 84-88 33181835-6 2021 Patients with SCD and either myocardial fibrosis or increased QTc displayed greater IL18 gene expression in peripheral blood mononuclear cells (PBMC), with QTc strongly correlated with plasma IL-18 levels. qtc 62-65 interleukin 18 Homo sapiens 192-197 33433347-5 2021 Simultaneously, Mo or/and Cd upregulated ASC, NLRP3, NEK7, Caspase-1, GSDMA, GSDME, IL-18 and IL-1beta mRNA levels and Caspase-1 p20, NLRP3, ASC, GSDMD protein levels, increased the percentage of pyroptotic cells, LDH, NO, IL-18 and IL-1beta releases as well as relative conductivity. Cadmium 26-28 interleukin 18 Homo sapiens 223-228 33613529-18 2020 Discussion: Our data suggest that NLRP3 activation using Nigericin could be a novel therapeutic approach to control the growth of tumors producing a low level of IL-1beta and IL-18. Nigericin 57-66 interleukin 18 Homo sapiens 175-180 33593369-5 2021 Colchicine has many anti-inflammatory and cardiovascular protective properties, including inhibition of IL-1beta and IL-18 activity, key proinflammatory cytokines that are predictive of future adverse cardiovascular events. Colchicine 0-10 interleukin 18 Homo sapiens 117-122 33613529-11 2020 Results: LPS/Nigericin increased NRLP3 protein expression as well as IL-1beta and IL-18 secretion in PC3 and U138MG cells compared to A549, MCF7, SH-SY5Y cells, and fibroblasts. Nigericin 13-22 interleukin 18 Homo sapiens 82-87 33626512-4 2021 Treating bone marrow-derived macrophages (BMDMs) with nicotine in vitro led to enhanced lipid phagocytosis, chemotaxis, and increased production of reactive oxygen species (ROS), which activated TXNIP/NLRP3 inflammasome signaling and promoted pyroptosis, as evidenced by caspase-1 cleavage and increased production of IL-1beta, IL-18, and gasdermin D. Nicotine 54-62 interleukin 18 Homo sapiens 328-333 33626512-4 2021 Treating bone marrow-derived macrophages (BMDMs) with nicotine in vitro led to enhanced lipid phagocytosis, chemotaxis, and increased production of reactive oxygen species (ROS), which activated TXNIP/NLRP3 inflammasome signaling and promoted pyroptosis, as evidenced by caspase-1 cleavage and increased production of IL-1beta, IL-18, and gasdermin D. Reactive Oxygen Species 173-176 interleukin 18 Homo sapiens 328-333 33521454-0 2021 Roflumilast Reduced the IL-18-Induced Inflammatory Response in Fibroblast-Like Synoviocytes (FLS). Roflumilast 0-11 interleukin 18 Homo sapiens 24-29 33484807-8 2021 The possible role of Desulfovibrio in gastric cancer was assessed with H2S-treated HT-29 cells, and the results showed that H2S induced NO, IL-1beta and IL-18 production, which is important for inflammation promotion and can be delivered through the bloodstream. Deuterium 124-127 interleukin 18 Homo sapiens 153-158 33469482-7 2021 Quercetin inhibited angiogenesis of HRMECs as well as the expressions of NLRP3, ASC, Caspase-1, IL-1beta, IL-18, LC3, Beclin-1, and autophagy of HRMECs under a HG condition. Quercetin 0-9 interleukin 18 Homo sapiens 106-111 33309621-2 2021 Reactive oxygen species (ROS) has been shown to activate pyroptosis and promote the production of interleukin (IL)-1beta and IL-18, leading to fibrosis development. Reactive Oxygen Species 0-23 interleukin 18 Homo sapiens 125-130 33309621-2 2021 Reactive oxygen species (ROS) has been shown to activate pyroptosis and promote the production of interleukin (IL)-1beta and IL-18, leading to fibrosis development. Reactive Oxygen Species 25-28 interleukin 18 Homo sapiens 125-130 32792028-6 2021 Dietary OxBC supplementation decreased the TNF-alpha and IL-8 levels in colostrum, as well as the TNF-alpha and IL-18 levels in 14-d milk. dietary oxbc 0-12 interleukin 18 Homo sapiens 112-117 33521454-4 2021 We found that roflumilast attenuated IL-18-induced oxidative stress by reducing the production of reactive oxygen species and malondialdehyde (MDA) in MH7A fibroblast-like synoviocytes (FLS). Roflumilast 14-25 interleukin 18 Homo sapiens 37-42 33521454-4 2021 We found that roflumilast attenuated IL-18-induced oxidative stress by reducing the production of reactive oxygen species and malondialdehyde (MDA) in MH7A fibroblast-like synoviocytes (FLS). Reactive Oxygen Species 98-121 interleukin 18 Homo sapiens 37-42 33521454-4 2021 We found that roflumilast attenuated IL-18-induced oxidative stress by reducing the production of reactive oxygen species and malondialdehyde (MDA) in MH7A fibroblast-like synoviocytes (FLS). Malondialdehyde 126-141 interleukin 18 Homo sapiens 37-42 33521454-4 2021 We found that roflumilast attenuated IL-18-induced oxidative stress by reducing the production of reactive oxygen species and malondialdehyde (MDA) in MH7A fibroblast-like synoviocytes (FLS). Malondialdehyde 143-146 interleukin 18 Homo sapiens 37-42 33521454-5 2021 Additionally, roflumilast prevented IL-18-induced expressions and secretions of pro-inflammatory cytokines such as IL-6, IL-8, and TNF-alpha. Roflumilast 14-25 interleukin 18 Homo sapiens 36-41 33521454-6 2021 Importantly, we found that roflumilast inhibited IL-18-induced expressions of chemokines such as CCL5, CXCL9, and CXCL10. Roflumilast 27-38 interleukin 18 Homo sapiens 49-54 33002740-16 2021 Serum IL-18 were correlated with other inflammatory markers and biochemical markers of organ injury; creatinine, liver enzymes and troponin. Creatinine 101-111 interleukin 18 Homo sapiens 6-11 32896640-8 2021 The levels of IL-1b, IL-18, and TSLP exhibited positive correlations with the AD severity index (Scoring AD index) and skin transepidermal water loss (TEWL), whereas an inverse correlation between IL-1a and Scoring AD index and IL-1a and TEWL was found. Water 139-144 interleukin 18 Homo sapiens 21-26 33436541-4 2021 The present study demonstrated that DHA and AA ameliorated lipopolysaccharide (LPS)-induced Kupffer cells pyroptosis by reversing the increased expression of NLRP3 inflammasome complex, GSDMD, IL-1beta, IL-18, and PI-stained positive rate. Docosahexaenoic Acids 36-39 interleukin 18 Homo sapiens 203-208 33430857-9 2021 Single LPS treatment for chondrocytes downregulated the Col II expression while upregulated the expression of IL-1beta, IL-18, and MMP-13, which was further changed by ATP treatment. Adenosine Triphosphate 168-171 interleukin 18 Homo sapiens 120-125 33430114-7 2021 ALA significantly reduces ER-beta, NALP-3 protein expression/activity and the secretion of IL-1beta and IL-18 in both 12Z and 22B cells. Thioctic Acid 0-3 interleukin 18 Homo sapiens 104-109 33160017-0 2021 The SGLT2 inhibitor Empagliflozin attenuates interleukin-17A-induced human aortic smooth muscle cell proliferation and migration by targeting TRAF3IP2/ROS/NLRP3/Caspase-1-dependent IL-1beta and IL-18 secretion. empagliflozin 20-33 interleukin 18 Homo sapiens 194-199 33160017-6 2021 Importantly, SMC express SGLT2, and pre-treatment with EMPA attenuated IL-17A/TRAF3IP2-dependent oxidative stress, NLRP3 expression, caspase-1 activation, IL-1beta and IL-18 secretion, and SMC proliferation and migration. empagliflozin 55-59 interleukin 18 Homo sapiens 168-173 32638280-10 2021 There was also a positive correlation between IL-18 or IL-1beta and 17-alpha-hydroxypregnenolone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, testosterone, dihydrotestosterone, progesterone, corticosterone, 11-deoxycorticosterone, and the ratio of DHEAS/cortisol. Dehydroepiandrosterone Sulfate 173-178 interleukin 18 Homo sapiens 46-51 33283480-8 2021 C-NP nanoparticles also stimulate the release of IL-lbeta, MCP-1, TNF-alpha, IL-8, IL-12p70, IL-17, IL-18, and IL-23 from MDM. c-np 0-4 interleukin 18 Homo sapiens 100-105 32638280-3 2021 Therefore, we correlated seminal IL-18 with IL-1beta and both cytokines with the seminal steroids, whose increase indicates the activation of neuroendocrine stress response systems. Steroids 89-97 interleukin 18 Homo sapiens 33-38 32638280-10 2021 There was also a positive correlation between IL-18 or IL-1beta and 17-alpha-hydroxypregnenolone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, testosterone, dihydrotestosterone, progesterone, corticosterone, 11-deoxycorticosterone, and the ratio of DHEAS/cortisol. 17-alpha-Hydroxypregnenolone 68-96 interleukin 18 Homo sapiens 46-51 32638280-10 2021 There was also a positive correlation between IL-18 or IL-1beta and 17-alpha-hydroxypregnenolone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, testosterone, dihydrotestosterone, progesterone, corticosterone, 11-deoxycorticosterone, and the ratio of DHEAS/cortisol. Dehydroepiandrosterone Sulfate 159-171 interleukin 18 Homo sapiens 46-51 32638280-10 2021 There was also a positive correlation between IL-18 or IL-1beta and 17-alpha-hydroxypregnenolone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, testosterone, dihydrotestosterone, progesterone, corticosterone, 11-deoxycorticosterone, and the ratio of DHEAS/cortisol. Androstenedione 181-196 interleukin 18 Homo sapiens 46-51 32638280-10 2021 There was also a positive correlation between IL-18 or IL-1beta and 17-alpha-hydroxypregnenolone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, testosterone, dihydrotestosterone, progesterone, corticosterone, 11-deoxycorticosterone, and the ratio of DHEAS/cortisol. Testosterone 198-210 interleukin 18 Homo sapiens 46-51 32638280-10 2021 There was also a positive correlation between IL-18 or IL-1beta and 17-alpha-hydroxypregnenolone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, testosterone, dihydrotestosterone, progesterone, corticosterone, 11-deoxycorticosterone, and the ratio of DHEAS/cortisol. Dihydrotestosterone 212-231 interleukin 18 Homo sapiens 46-51 32638280-10 2021 There was also a positive correlation between IL-18 or IL-1beta and 17-alpha-hydroxypregnenolone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, testosterone, dihydrotestosterone, progesterone, corticosterone, 11-deoxycorticosterone, and the ratio of DHEAS/cortisol. Corticosterone 247-261 interleukin 18 Homo sapiens 46-51 32638280-10 2021 There was also a positive correlation between IL-18 or IL-1beta and 17-alpha-hydroxypregnenolone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, testosterone, dihydrotestosterone, progesterone, corticosterone, 11-deoxycorticosterone, and the ratio of DHEAS/cortisol. Desoxycorticosterone 263-285 interleukin 18 Homo sapiens 46-51 32638280-10 2021 There was also a positive correlation between IL-18 or IL-1beta and 17-alpha-hydroxypregnenolone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, testosterone, dihydrotestosterone, progesterone, corticosterone, 11-deoxycorticosterone, and the ratio of DHEAS/cortisol. Dehydroepiandrosterone Sulfate 304-309 interleukin 18 Homo sapiens 46-51 32638280-10 2021 There was also a positive correlation between IL-18 or IL-1beta and 17-alpha-hydroxypregnenolone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, testosterone, dihydrotestosterone, progesterone, corticosterone, 11-deoxycorticosterone, and the ratio of DHEAS/cortisol. Hydrocortisone 310-318 interleukin 18 Homo sapiens 46-51 33414782-7 2020 Overexpression of Gm28309 or inhibition of miR-3068-5p repressed p65 phosphorylation and reduced NLRP3 inflammasome and IL-1beta and IL-18 secretion. gm28309 18-25 interleukin 18 Homo sapiens 133-138 33414782-7 2020 Overexpression of Gm28309 or inhibition of miR-3068-5p repressed p65 phosphorylation and reduced NLRP3 inflammasome and IL-1beta and IL-18 secretion. mir-3068 43-51 interleukin 18 Homo sapiens 133-138 32506648-8 2020 Results showed that UA exposure inhibited cell viability and increased IL-1beta and IL-18 generation in a concentration dependent manner. Uric Acid 20-22 interleukin 18 Homo sapiens 84-89 33038386-2 2020 Interleukin-18 (IL-18) is a determinant factor in controlling the balance of Th1/Th2 during antiviral response.Weexamine therole of two functional polymorphisms -607A/C and-137A/C inIL-18 gene with risk of chronic HBV infection. weexamine therole 111-128 interleukin 18 Homo sapiens 0-14 33038386-2 2020 Interleukin-18 (IL-18) is a determinant factor in controlling the balance of Th1/Th2 during antiviral response.Weexamine therole of two functional polymorphisms -607A/C and-137A/C inIL-18 gene with risk of chronic HBV infection. weexamine therole 111-128 interleukin 18 Homo sapiens 16-21 32098511-8 2020 Doxofylline inhibits LPS-induced NLRP3-TXNIP inflammasome activation as revealed by its inhibitive effect on NLRP3, caspase 1 (P10 unit), and TXNIP induction as well as weakened induction of IL-1beta and IL-18. doxofylline 0-11 interleukin 18 Homo sapiens 204-209 33100863-7 2020 The IL-18BP elevation in ATB group was accompanied by an increase in IL-18. 4-anisyltetrazolium blue 25-28 interleukin 18 Homo sapiens 4-9 32616329-0 2020 Serum interleukin-18 levels as a predictor for patients with genetic dysfunction of cytochrome P450 2C19 in dual antiplatelet therapy with clopidogrel. Clopidogrel 139-150 interleukin 18 Homo sapiens 6-20 32616329-8 2020 CONCLUSIONS: The serum levels of interleukin-18 may be a predictor to diagnose patients who receive undesirable DAPT with clopidogrel, possibly due to the genetic dysfunction of CYP2C19 in spite of suitable P2Y12 reactions after PCI. Clopidogrel 122-133 interleukin 18 Homo sapiens 33-47 32866784-8 2020 Additionally, IL-1beta/IL-18 secretion from ATP + LPS stimulated THP-1-derived macrophages was RalA-dependently suppressed by levornidazole, suggesting that RalA might have an inhibitory effect on NLRP3 inflammasome activation. Adenosine Triphosphate 44-47 interleukin 18 Homo sapiens 23-28 32941596-3 2020 Nucleotide-binding and leucine-rich repeat-containing receptors (NLRs) encompass a large number of innate immune sensors and receptors, which mediate the activation of Caspase-1 and the subsequent release of mature interleukin-1beta and interleukin-18. Leucine 23-30 interleukin 18 Homo sapiens 237-251 33144845-6 2020 Despite using doses of the inflammasome inducers yielding similar release of IL-1beta, SiO2-stimulated cells showed a lower concentration of released IL-18 compared to ATP and chitosan. Silicon Dioxide 87-91 interleukin 18 Homo sapiens 150-155 33144845-7 2020 Hence, the cells stimulated with SiO2 responded with a distinctly different IL-18 : IL-1beta ratio. Silicon Dioxide 33-37 interleukin 18 Homo sapiens 76-81 33144845-8 2020 The difference in the IL-18 : IL-1beta ratio for SiO2 was constant over different doses. Silicon Dioxide 49-53 interleukin 18 Homo sapiens 22-27 33497945-3 2020 The results evidenced that Cd significantly increased the releases of interleukin-18 (IL-18) and interleukin-1beta (IL-1beta), lactate dehydrogenase (LDH) and nitric oxide (NO), relative conductivity and cellular reactive oxygen species (ROS) level. Cadmium 27-29 interleukin 18 Homo sapiens 70-84 33497945-3 2020 The results evidenced that Cd significantly increased the releases of interleukin-18 (IL-18) and interleukin-1beta (IL-1beta), lactate dehydrogenase (LDH) and nitric oxide (NO), relative conductivity and cellular reactive oxygen species (ROS) level. Cadmium 27-29 interleukin 18 Homo sapiens 86-91 33497945-4 2020 Simultaneously, Cd also markedly upregulated NLRP3, Caspase-1, ASC, NEK7, IL-1beta and IL-18 mRNA levels and NLRP3, Caspase-1 p20, GSDMD and ASC protein levels. Cadmium 16-18 interleukin 18 Homo sapiens 87-92 33101286-6 2020 NLRP3 activator nigericin caused the processing and release of constitutively expressed IL-18 in an unprimed setting. Nigericin 16-25 interleukin 18 Homo sapiens 88-93 32611559-4 2020 On this basis, colchicine interferes with several functions of leucocytes and the assembly and activation of the inflammasome as well, reducing the production of interleukin 1beta and interleukin 18. Colchicine 15-25 interleukin 18 Homo sapiens 184-198 33000581-10 2020 The mechanism could be that it reduced ROS produce and inhibited NLRP3 inflammasome activation so that mainly lower the downstream inflammatory cytokines IL-1beta and IL-18. Reactive Oxygen Species 39-42 interleukin 18 Homo sapiens 167-172 32504923-8 2020 NAC has also been shown to inhibit the NLRP3 inflammasome pathway (IL1beta and IL18) in vitro, and decrease plasma TNF-alpha in human clinical trials. Acetylcysteine 0-3 interleukin 18 Homo sapiens 79-83 32967076-5 2020 Patients treated with metformin showed decreased levels of all analyzed serum pro-inflammatory markers (TNFalpha, IL6, IL1beta and MCP1) and a downwards trend in IL18 levels associated with a lower production of oxidative stress markers in leukocytes (mitochondrial ROS and myeloperoxidase (MPO)). Metformin 22-31 interleukin 18 Homo sapiens 162-166 31954830-5 2020 Similarly, the levels of the NLRP1 inflammasome proteins, cleaved caspase-1, mature IL-1beta and IL-18 were elevated in SY-5Y cells exposed to oxygen-glucose deprivation (OGD). Oxygen 143-157 interleukin 18 Homo sapiens 97-102 32710733-11 2020 The stimulation could occur by way of IL-6 / JAK2 / STAT3 / SOCS3 and NF-kappaB (p65)/IL-18, which work together to induce AKI and increase overall renal-related diagnostic markers, such as plasma creatinine and tubular cell damage. Creatinine 197-207 interleukin 18 Homo sapiens 86-91 32911690-6 2020 Interestingly, the increased IL-18 only decreased by vitamin D addition in endothelial cells but not in RPE cells, suggesting a main antiangiogenic role under inflammatory conditions. Vitamin D 53-62 interleukin 18 Homo sapiens 29-34 32911914-2 2020 Reactive oxygen species, high concentrations of adenosine triphosphate and uric acid activate the pyroptosis system, which then cleaves the pore formation mechanism of gasdermin-D, leading to the death of liver cells, accompanied by the release of interleukin-1beta, interleukin-18, and other inflammatory factors. Oxygen 9-15 interleukin 18 Homo sapiens 267-281 32911914-2 2020 Reactive oxygen species, high concentrations of adenosine triphosphate and uric acid activate the pyroptosis system, which then cleaves the pore formation mechanism of gasdermin-D, leading to the death of liver cells, accompanied by the release of interleukin-1beta, interleukin-18, and other inflammatory factors. Adenosine 48-57 interleukin 18 Homo sapiens 267-281 32911914-2 2020 Reactive oxygen species, high concentrations of adenosine triphosphate and uric acid activate the pyroptosis system, which then cleaves the pore formation mechanism of gasdermin-D, leading to the death of liver cells, accompanied by the release of interleukin-1beta, interleukin-18, and other inflammatory factors. Uric Acid 75-84 interleukin 18 Homo sapiens 267-281 32954194-4 2020 Ropivacaine treatment exerted significant beneficial effects by rescuing oxidative stress and downregulating interleukin (IL)-1beta and IL-18. Ropivacaine 0-11 interleukin 18 Homo sapiens 136-141 32035094-7 2020 Treatment with ATP caused the activation of caspase-1 as well as the production of active forms of IL-1beta and IL-18 via P2X7 receptor (P2X7R) in keratinocytes and melanocytes. Adenosine Triphosphate 15-18 interleukin 18 Homo sapiens 112-117 32855770-9 2020 In addition, pretreatment with BB extracts was able to prevent ozone-induced ROS production and inflammasome activation measured as NRLP1-ASC scaffold formation and also prevent the transcripts of key inflammasome players such as CASP1 and IL-18, suggesting that this approach as a possible new technology to prevent cutaneous pollution damage. Ozone 63-68 interleukin 18 Homo sapiens 240-245 32851082-0 2020 Rapamycin Inhibited Pyroptosis and Reduced the Release of IL-1beta and IL-18 in the Septic Response. Sirolimus 0-9 interleukin 18 Homo sapiens 71-76 32851082-8 2020 This study shows that RAPA abrogates LPS-mediated increase in IL-1beta and IL-18 by inhibiting pyroptosis and enhancing autophagy. Sirolimus 22-26 interleukin 18 Homo sapiens 75-80 32470548-4 2020 Furthermore, the recombinant protein blocked reactive oxygen species (ROS) production, abated mitochondrial dysfunction and significantly suppressed the assembly of the inflammasome, which led to the overproduction of proinflammatory cytokines IL-1beta and IL-18. Reactive Oxygen Species 45-68 interleukin 18 Homo sapiens 257-262 32470548-4 2020 Furthermore, the recombinant protein blocked reactive oxygen species (ROS) production, abated mitochondrial dysfunction and significantly suppressed the assembly of the inflammasome, which led to the overproduction of proinflammatory cytokines IL-1beta and IL-18. Reactive Oxygen Species 70-73 interleukin 18 Homo sapiens 257-262 32968631-14 2020 Cur attenuated DOX-induced cardiomyocyte pyroptosis as evidenced by NLR family pyrin domain containing 3 (NLRP3), Caspase-1, and interleukin-18 levels. Doxorubicin 15-18 interleukin 18 Homo sapiens 129-143 32849554-2 2020 The NOD-, LRR- and pyrin domain containing protein 3 (NLRP3) is an innate immune signaling complex whose assembly and activation can be triggered by various signals ranging from microbial molecules to ATP or the abnormal accumulation of crystals, thus leading to IL-1beta and IL-18 maturation and secretion. Adenosine Triphosphate 201-204 interleukin 18 Homo sapiens 276-281 32659652-9 2020 Further analyses showed significantly higher concentration of IL-18 among participants using carbamazepine (CBZ) (p = 0.016) or lamotrigine (LTG) (p = 0.024), but not in those using levetiracetam (LEV) (p = 0.102) compared to controls. Carbamazepine 93-106 interleukin 18 Homo sapiens 62-67 32659652-9 2020 Further analyses showed significantly higher concentration of IL-18 among participants using carbamazepine (CBZ) (p = 0.016) or lamotrigine (LTG) (p = 0.024), but not in those using levetiracetam (LEV) (p = 0.102) compared to controls. Carbamazepine 108-111 interleukin 18 Homo sapiens 62-67 32659652-9 2020 Further analyses showed significantly higher concentration of IL-18 among participants using carbamazepine (CBZ) (p = 0.016) or lamotrigine (LTG) (p = 0.024), but not in those using levetiracetam (LEV) (p = 0.102) compared to controls. Lamotrigine 128-139 interleukin 18 Homo sapiens 62-67 32659652-9 2020 Further analyses showed significantly higher concentration of IL-18 among participants using carbamazepine (CBZ) (p = 0.016) or lamotrigine (LTG) (p = 0.024), but not in those using levetiracetam (LEV) (p = 0.102) compared to controls. Lamotrigine 141-144 interleukin 18 Homo sapiens 62-67 32659652-9 2020 Further analyses showed significantly higher concentration of IL-18 among participants using carbamazepine (CBZ) (p = 0.016) or lamotrigine (LTG) (p = 0.024), but not in those using levetiracetam (LEV) (p = 0.102) compared to controls. Levetiracetam 197-200 interleukin 18 Homo sapiens 62-67 32650532-4 2020 Although the mechanism is very complex and needs further explanation, it appears that high levels of cholesterol, urate, and glucose activates NLRP3 inflammasome, which produces IL-1beta, IL-18, and gasdermin D. Cholesterol 101-112 interleukin 18 Homo sapiens 188-193 32751912-2 2020 More than half a decade ago, it has been shown that the inflammasome adaptor molecule, ASC requires tyrosine phosphorylation to allow effective inflammasome assembly and sustained IL-1beta/IL-18 release. Tyrosine 100-108 interleukin 18 Homo sapiens 189-194 32751912-4 2020 In the subsequent years, it was reported that activation of the inflammasome receptor molecule, NLRP3, is modulated via tyrosine phosphorylation as well, and that NLRP3 de-phosphorylation at specific tyrosine residues was required for inflammasome assembly and sustained IL-1beta/IL-18 release. Tyrosine 200-208 interleukin 18 Homo sapiens 280-285 32698510-12 2020 Ruxolitinib reverted IFN-gamma-induced expression of caspase-1, IL-1beta, IL-15, and IL-18, and stimulated several growth factors, such as FGF7. ruxolitinib 0-11 interleukin 18 Homo sapiens 85-90 32650532-4 2020 Although the mechanism is very complex and needs further explanation, it appears that high levels of cholesterol, urate, and glucose activates NLRP3 inflammasome, which produces IL-1beta, IL-18, and gasdermin D. Uric Acid 114-119 interleukin 18 Homo sapiens 188-193 32650532-4 2020 Although the mechanism is very complex and needs further explanation, it appears that high levels of cholesterol, urate, and glucose activates NLRP3 inflammasome, which produces IL-1beta, IL-18, and gasdermin D. Glucose 125-132 interleukin 18 Homo sapiens 188-193 32347316-6 2020 RESULTS: In hydrogen peroxide (H2O2)-stimulated HL7702 cells, HBx triggered the release of pro-inflammatory mediators apoptosis-associated speck-like protein containing a CARD (ASC), interleukin (IL)-1beta, IL-18, and high-mobility group box 1 (HMGB1); activated NLRP3; and initiated pro-inflammatory cell death (pyroptosis). Hydrogen Peroxide 12-29 interleukin 18 Homo sapiens 207-212 32315958-8 2020 RESULTS: Following butyrate supplementation, the relative expression levels of TLR2/4, NF-kappaB1, Caspase-1, NLRP3, IL-1beta & IL-18 were significantly downregulated (p < 0.05). Butyrates 19-27 interleukin 18 Homo sapiens 128-133 32347316-6 2020 RESULTS: In hydrogen peroxide (H2O2)-stimulated HL7702 cells, HBx triggered the release of pro-inflammatory mediators apoptosis-associated speck-like protein containing a CARD (ASC), interleukin (IL)-1beta, IL-18, and high-mobility group box 1 (HMGB1); activated NLRP3; and initiated pro-inflammatory cell death (pyroptosis). Hydrogen Peroxide 31-35 interleukin 18 Homo sapiens 207-212 32714980-8 2020 Mechanically, CD147 promoted phosphorylation of NF-kappaB p65 in IECs, while inhibition of NF-kappaB activity by the NF-kappaB inhibitor BAY11-7082 reversed the effect of CD147 on IL-1beta and IL-18 secretion. 3-(4-methylphenylsulfonyl)-2-propenenitrile 137-147 interleukin 18 Homo sapiens 193-198 32855848-4 2020 The present study aimed to assess the efficacy of 3TC against Alu RNA-induced RPE inflammation and senescence by evaluating changes in expression of the proinflammatory cytokines IL-18 and IL-1beta and of p16INK4a in RPE cells. Lamivudine 50-53 interleukin 18 Homo sapiens 179-184 32855848-6 2020 Results: Treatment with 3TC markedly reduced Alu RNA-induced expression of IL-18 and IL-1beta in human and mouse RPE cells compared with the negative control. Lamivudine 24-27 interleukin 18 Homo sapiens 75-80 32209332-9 2020 Serum levels of IL-18 were significantly higher in CC carriers (843.1 pg/mL) compared with GG or GC carriers (303.6 pg/mL and 292.0 pg/mL, respectively). gallocatechol 97-99 interleukin 18 Homo sapiens 16-21 32629886-5 2020 Interestingly, NaHS also stimulated the caspase-1 inflammasome pathway, leading to increased secretion of the pro-inflammatory molecule interleukin-18 (IL-18). sodium bisulfide 15-19 interleukin 18 Homo sapiens 136-150 32629886-5 2020 Interestingly, NaHS also stimulated the caspase-1 inflammasome pathway, leading to increased secretion of the pro-inflammatory molecule interleukin-18 (IL-18). sodium bisulfide 15-19 interleukin 18 Homo sapiens 152-157 32289583-11 2020 After adjusting for age, gender, BMI, family income, parental education level, and second-hand smoke exposure, we found that increased PAH exposure was associated with higher AhR and NLRP3 expression and elevated IL-4, IL-10, IL-12p70, IL-18, IL-22, IL-23, TNF-alpha, and IFN-gamma levels. Polycyclic Aromatic Hydrocarbons 135-138 interleukin 18 Homo sapiens 236-241 32289583-12 2020 The associations between PAH exposure and IL-1beta, IL-18, IFN-gamma, and TNF-beta were mediated by NLRP3 expression, and the relationships between PAH exposure and IL-4, IL-10, IL-12p70, IL-22, IL-23, and TNF-alpha were mediated by AhR expression. Polycyclic Aromatic Hydrocarbons 25-28 interleukin 18 Homo sapiens 52-57 32564053-7 2020 RESULTS Compared with the healthy controls, the serum expression of IL-18, IL-33, IFN-gamma, IL-5, IL-6, IL-8, and IL-13 were significantly higher in the MPP and NMPP groups. nmpp 162-166 interleukin 18 Homo sapiens 68-73 32564053-9 2020 Significant differences were also observed between the MPP group and NMPP group patients in levels of IL-18, IL-5, and IL-6, and further ROC analysis showed that the area under the curve (AUC) of IL-18 and IL-5 were 0.813 (95% CI: 0.710-0.917; P<0.01) and 0.844 (95% CI: 0.756-0.933; P<0.01), respectively. nmpp 69-73 interleukin 18 Homo sapiens 102-107 32564053-9 2020 Significant differences were also observed between the MPP group and NMPP group patients in levels of IL-18, IL-5, and IL-6, and further ROC analysis showed that the area under the curve (AUC) of IL-18 and IL-5 were 0.813 (95% CI: 0.710-0.917; P<0.01) and 0.844 (95% CI: 0.756-0.933; P<0.01), respectively. nmpp 69-73 interleukin 18 Homo sapiens 196-201 32633386-13 2020 There was a remarkable association between CT genotype at IL-18 gene locus rs360715 and partial pressure of oxygen (PaO2) (p=0.035), and between CC genotype at IL-9 gene locus rs2066758 and partial pressure of carbon dioxide (PaCO2) (p=0.041). Oxygen 108-114 interleukin 18 Homo sapiens 58-63 32633386-13 2020 There was a remarkable association between CT genotype at IL-18 gene locus rs360715 and partial pressure of oxygen (PaO2) (p=0.035), and between CC genotype at IL-9 gene locus rs2066758 and partial pressure of carbon dioxide (PaCO2) (p=0.041). pao2 116-120 interleukin 18 Homo sapiens 58-63 31863285-4 2020 In certain cell types, IL-18 also activates mitogen-activated protein kinases (MAPKs) and phosphoinositide 3-kinase/ AKT serine/threonine kinase (PI3K/AKT) signaling modules leading to the production and release of proinflammatory cytokines. cholecystokinin C-terminal flanking peptide 121-127 interleukin 18 Homo sapiens 23-28 32249647-7 2020 Consistently, laquinimod prevented MPP+-induced secretions of interleukin 1beta (IL-1beta) and interleukin-18 (IL-18). laquinimod 14-24 interleukin 18 Homo sapiens 95-109 32249647-7 2020 Consistently, laquinimod prevented MPP+-induced secretions of interleukin 1beta (IL-1beta) and interleukin-18 (IL-18). laquinimod 14-24 interleukin 18 Homo sapiens 111-116 32249647-7 2020 Consistently, laquinimod prevented MPP+-induced secretions of interleukin 1beta (IL-1beta) and interleukin-18 (IL-18). mangion-purified polysaccharide (Candida albicans) 35-39 interleukin 18 Homo sapiens 95-109 32249647-7 2020 Consistently, laquinimod prevented MPP+-induced secretions of interleukin 1beta (IL-1beta) and interleukin-18 (IL-18). mangion-purified polysaccharide (Candida albicans) 35-39 interleukin 18 Homo sapiens 111-116 31863285-4 2020 In certain cell types, IL-18 also activates mitogen-activated protein kinases (MAPKs) and phosphoinositide 3-kinase/ AKT serine/threonine kinase (PI3K/AKT) signaling modules leading to the production and release of proinflammatory cytokines. glycyl-threonine 128-137 interleukin 18 Homo sapiens 23-28 32439949-5 2020 An in vitro study indicated that high glucose increased IL-1beta and IL-18 expression and activated the NLRP3 inflammasome via upregulation of MARK4 in human umbilical vein endothelial cells (HUVECs). Glucose 38-45 interleukin 18 Homo sapiens 69-74 32018221-3 2020 Notably, we found that high-glucose (50 mM) increased the expression levels of Caspase-1, Gasdermin D, NLRP3, IL-1beta and IL-18 in ARPE-19 cells, which indicated that high-glucose triggered pyroptotic cell death. Glucose 173-180 interleukin 18 Homo sapiens 123-128 32423023-1 2020 The NLRP3 (nucleotide-binding domain, leucine-rich-repeat-containing family, pyrin domain-containing 3) inflammasome senses pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs), and activates caspase-1, which provokes release of proinflammatory cytokines such as interleukin-1beta (IL-1beta) and IL-18 as well as pyroptosis to engage in innate immune defense. Leucine 38-45 interleukin 18 Homo sapiens 339-344 32018221-3 2020 Notably, we found that high-glucose (50 mM) increased the expression levels of Caspase-1, Gasdermin D, NLRP3, IL-1beta and IL-18 in ARPE-19 cells, which indicated that high-glucose triggered pyroptotic cell death. Glucose 28-35 interleukin 18 Homo sapiens 123-128 31714001-4 2020 Since glyburide (a specific inhibitor of K+ efflux channels) inhibited the transcription of NLRP3, IL-1beta, and IL-18, the role of K+ efflux in the activation of inflammasomes in APOL1 risk milieu was implicated. Glyburide 6-15 interleukin 18 Homo sapiens 113-118 32271889-12 2020 Additionally, UV-B stimulated the caspase-1-independent production of IL-18, an effect also reduced by cis-UCA. cis-Urocanic acid 103-110 interleukin 18 Homo sapiens 70-75 32190930-9 2020 At the mechanistic level, the release of IL-1beta was regulated by K+ efflux, whereas the secretion of IL-18 was dependent on ROS production. Reactive Oxygen Species 126-129 interleukin 18 Homo sapiens 103-108 32190930-11 2020 Collectively, our data suggest that UVB clearly stimulates the secretion of mature IL-18 as a result of ROS induction, and this response is associated with DNA damage. Reactive Oxygen Species 104-107 interleukin 18 Homo sapiens 83-88 32316978-9 2020 After three injections, DCV-treated patients showed correlative grouping among Th1/Th17 cytokines on PC-1, with an inverse correlation with B2M, FAS, and IL-18, and correlations among immunoglobulins in PC-2. DyeCycle Violet 24-27 interleukin 18 Homo sapiens 154-159 32035144-4 2020 Our results showed that hesperetin significantly relieved the symptoms of DSS -induced colitis and increased the expressions of zonula occludens-1 (ZO-1), occludin and mucin2 (MUC-2) as well as the decrease of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-18, HMGB1 and IL-6. hesperetin 24-34 interleukin 18 Homo sapiens 275-280 32420343-6 2020 Our data showed that high glucose induced NLRP3-caspase-1-GSDMD activation and pore formation in a dose- and time-dependent manner (p < 0.05) and resulted in the inflammatory cytokines IL-1beta and IL-18 and lactate dehydrogenase (LDH) release from HRPs (p < 0.05), which are all signs of HRP pyroptosis. Glucose 26-33 interleukin 18 Homo sapiens 198-203 32271889-15 2020 Cis-UCA can prevent the secretion of IL-1beta and IL-18 and therapeutically reduces the levels of IL-6, IL-8, and LDH in UV-B-stressed HCE cells. cis-Urocanic acid 0-7 interleukin 18 Homo sapiens 50-55 32132181-8 2020 Thus, AmB induced IL-1beta and IL-18 secretions, which are reduced by specific inhibitors of caspase activation (Q-VD) and NLRP3 activation (MCC950). Amphotericin B 6-9 interleukin 18 Homo sapiens 31-36 32252692-11 2020 The levels of inflammation related proteins NLRP3, ASC, caspase1, IL-1beta and IL-18 was also inhibited after the treatment of ripasudil. K-115 127-136 interleukin 18 Homo sapiens 79-84 32252692-13 2020 CONCLUSION: Ripasudil relieved the inflammatory injury of RPE cells by upregulating miR-136-5p, therefore inhibiting the expression of ROCK1, ROCK2, NLRP3, ASC, caspase1, IL-1beta and IL-18. K-115 12-21 interleukin 18 Homo sapiens 184-189 32028242-6 2020 Further analysis confirmed that BA could decrease the levels of NLRP3 and GSDMD, as well as the release of IL-1beta and IL-18, resulting in the reduction of pyroptosis. baicalin 32-34 interleukin 18 Homo sapiens 120-125 31996020-8 2020 Further, acute uric acid reduction by the administration of benzbromarone in healthy humans for 2 weeks significantly decreased plasma IL-18-an inflammasome-dependent cytokine. Uric Acid 15-24 interleukin 18 Homo sapiens 135-140 32207597-0 2021 Study of effect of metformin on expression levels of TNF-alpha and IL-18 in animal models of polycystic ovary syndrome. Metformin 19-28 interleukin 18 Homo sapiens 67-72 32091090-6 2020 Additionally, naringin restored endothelial barrier integrity by preventing VE-cadherin disassembly and F-actin remodeling, and downregulated pro-inflammatory factors like IL-1beta, IL-6, and IL-18, in the HUVECs. naringin 14-22 interleukin 18 Homo sapiens 192-197 32210598-9 2020 An LDH level above 436.5 IU/L and an IL-18 level above 464.5 pg/mL were the second most useful markers for RMPP: AUC 0.775, 0.775; SE 0.038, 0.039; 95% CI 0.700-0.850, 0.698-0.852; sensitivity 77.8%, 82.2%; specificity 62.4%, 59.6%; respectively. rmpp 107-111 interleukin 18 Homo sapiens 37-42 32118580-4 2020 In vitro application of ivacaftor/lumacaftor or ivacaftor/tezacaftor to CF monocytes showed a significant reduction in IL-18, whereas IL-1beta was only reduced with ivacaftor/tezacaftor. ivacaftor 24-33 interleukin 18 Homo sapiens 119-124 32118580-4 2020 In vitro application of ivacaftor/lumacaftor or ivacaftor/tezacaftor to CF monocytes showed a significant reduction in IL-18, whereas IL-1beta was only reduced with ivacaftor/tezacaftor. lumacaftor 34-44 interleukin 18 Homo sapiens 119-124 32118580-4 2020 In vitro application of ivacaftor/lumacaftor or ivacaftor/tezacaftor to CF monocytes showed a significant reduction in IL-18, whereas IL-1beta was only reduced with ivacaftor/tezacaftor. ivacaftor 48-57 interleukin 18 Homo sapiens 119-124 32118580-4 2020 In vitro application of ivacaftor/lumacaftor or ivacaftor/tezacaftor to CF monocytes showed a significant reduction in IL-18, whereas IL-1beta was only reduced with ivacaftor/tezacaftor. tezacaftor 58-68 interleukin 18 Homo sapiens 119-124 32118580-4 2020 In vitro application of ivacaftor/lumacaftor or ivacaftor/tezacaftor to CF monocytes showed a significant reduction in IL-18, whereas IL-1beta was only reduced with ivacaftor/tezacaftor. ivacaftor 48-57 interleukin 18 Homo sapiens 119-124 32118580-7 2020 In (LPS/ATP-stimulated) PBMCs, IL-18/TNF/caspase-1 were all significantly decreased and IL-10 was increased with both combinations. Adenosine Triphosphate 8-11 interleukin 18 Homo sapiens 31-36 31996020-8 2020 Further, acute uric acid reduction by the administration of benzbromarone in healthy humans for 2 weeks significantly decreased plasma IL-18-an inflammasome-dependent cytokine. Benzbromarone 60-73 interleukin 18 Homo sapiens 135-140 31761332-0 2020 Increased interleukin 18 activity in adolescents with early-onset psychosis is associated with cortisol and depressive symptoms. Hydrocortisone 95-103 interleukin 18 Homo sapiens 10-24 31998952-4 2020 In vivo and in vitro, IOP treatment caused renal damage and elevated the caspase-1 (+) PI (+) cell count, interleukin (IL)-1b and IL-18 levels, lactate dehydrogenase (LDH) release, and the relative expression of nucleotide-binding domain, leucine-rich repeat containing protein 3 (NLRP3), apoptosis-associated speck-like protein (ASC), and gasdermin D (GSDMD), suggesting that IOP induces AKI via the activation of pyroptosis. iopromide 22-25 interleukin 18 Homo sapiens 130-135 32053656-9 2020 Multiple linear regression analyses revealed the association of salivary IL-18 levels and fasting plasma glucose (beta = 0.270, p = 0.022) whereas serum IL-18 levels were associated with HbA1C (beta = 0.293, p = 0.017). Glucose 105-112 interleukin 18 Homo sapiens 73-78 32010303-9 2020 The results indicated reduced levels of IL-18 and IL-1beta in the supernatant of the cells of the pulegone groups when compared with those in the LPS + ATP/nigericin group. pulegone 98-106 interleukin 18 Homo sapiens 40-45 31506572-4 2020 We showed that isosibiricin (10-50 muM) dose-dependently inhibited lipopolysaccharide (LPS)-induced BV-2 microglia activation, evidenced by the decreased expression of inflammatory mediators, including nitrite oxide (NO), tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1beta (IL-1beta) and interleukin-18 (IL-18). Isosibiricin 15-27 interleukin 18 Homo sapiens 319-333 31506572-4 2020 We showed that isosibiricin (10-50 muM) dose-dependently inhibited lipopolysaccharide (LPS)-induced BV-2 microglia activation, evidenced by the decreased expression of inflammatory mediators, including nitrite oxide (NO), tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1beta (IL-1beta) and interleukin-18 (IL-18). Isosibiricin 15-27 interleukin 18 Homo sapiens 335-340 31761332-3 2020 We compared the associations of IL-18 with cortisol and clinical variables in adolescents with early-onset psychosis (EOP) aged 12-18 years and age-matched healthy controls (HC). Hydrocortisone 43-51 interleukin 18 Homo sapiens 32-37 31761332-6 2020 Bivariate correlation analysis was used to explore relationships between IL-18/IL-18BP ratio and cortisol, depression and other clinical characteristics. Hydrocortisone 97-105 interleukin 18 Homo sapiens 73-78 31761332-9 2020 Both cortisol (R2 change = 0.05) and the MFQ-C score (R2 change = 0.09) contributed significantly to the variance in IL-18/IL-18BP ratios after controlling for confounders. Hydrocortisone 5-13 interleukin 18 Homo sapiens 117-122 31761332-11 2020 Cortisol and depressive symptoms each contributed to the variance in the IL-18/IL-18BP ratio. Hydrocortisone 0-8 interleukin 18 Homo sapiens 73-78 31963828-1 2020 In two recent studies we have shown that three of the most abundant human hematopoietic serine proteases-mast cell chymase, mast cell tryptase and neutrophil cathepsin G-show a highly selective cleavage of cytokines and chemokines with a strong preference for a few alarmins, including IL-18, TSLP and IL-33. Serine 88-94 interleukin 18 Homo sapiens 286-291 32005256-9 2020 Our further findings revealed that treatment with SR9009 inhibited NLRP3 inflammasome activation, inflammatory cytokine (IL-1beta, IL-18, IL-6, and TNF-alpha) production, astrocytosis, microgliosis, and neuronal damage in the hippocampus after SE. SR9009 50-56 interleukin 18 Homo sapiens 131-136 31734578-10 2020 Moreover, in vivo, the combination of SFJDC and oseltamivir improved survival rates, attenuated clinical symptoms, induced weight gain, alleviated lung damage, and significantly reduced IL-1beta and IL-18 levels in serum and BALF, as well as reduced the expression levels of NLRP3-associated components and viral titers in lung homogenates. Oseltamivir 48-59 interleukin 18 Homo sapiens 199-204 31483910-8 2020 RESULTS: After treatment with resveratrol, it was found that serum levels of IL-6, IL-1beta, TNF-alpha, IL-18, NF-kappaB, and CRP decreased in treatment group. Resveratrol 30-41 interleukin 18 Homo sapiens 104-109 32067619-10 2020 Treatment with ruxolitinib decreased the expressions of IL-6, IL-18, JAK2, TYK2 and, AKT genes which play significant roles in MM pathogenesis. ruxolitinib 15-26 interleukin 18 Homo sapiens 62-67 31759058-5 2020 Pretreatment with CLI-095, a specific inhibitor of TLR4 signaling, dramatically diminished the TLMP-induced release of IL-1beta and IL-18 by inhibiting the formation of NLRP3/ASC/pro-caspase-1 inflammasome in a dose-dependent manner. tlmp 95-99 interleukin 18 Homo sapiens 132-137 32256196-0 2020 Quartz Dust Exposure Affects NLRP3 Inflammasome Activation and Plasma Levels of IL-18 and IL-1Ra in Iron Foundry Workers. Iron 100-104 interleukin 18 Homo sapiens 80-85 31469975-6 2020 Upstream and serving as an activator of IL-1ss lies the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome that has been well described in animal models to be activated by cholesterol crystals or hypoxia to promote cleavage and secretion of IL-1ss and IL-18 that lead to atherosclerotic deposition in arteries. Cholesterol 208-219 interleukin 18 Homo sapiens 288-293 33100082-8 2020 Receiver operating characteristic (ROC) analysis of SIPA revealed that increased production of IL-18 in the IBC-NST biopsy samples after exposure to PAs may block the PA-driven, cytokine-mediated differentiation of moderately differentiated into highly differentiated tumour cells. Protactinium 54-56 interleukin 18 Homo sapiens 95-100 31830726-5 2020 Atorvastatin inhibited pyroptosis by decreasing the expression levels of the canonical inflammasome pathway biomarkers NLRP3, caspase-1, GSDMD, IL-1beta, and IL-18 at both the mRNA and protein levels. atorvastatin 0-12 interleukin 18 Homo sapiens 158-163 31885713-9 2020 Furthermore, NaHS inhibited the expression of NLRP3, ASC and cleaved caspase-1, and the production of IL-1beta and IL-18 in adipocytes treated with HG. Sodium 13-17 interleukin 18 Homo sapiens 115-120 31805854-10 2019 Dexmedetomidine decreased the concentration of eotaxin, interleukin-18, interleukin-2Ralpha, stem cell factor, stem cell growth factor and vascular endothelial growth factor, and propofol decreased significantly the levels of hepatocyte growth factor, IFN-gamma-induced protein 10 and monokine induced by IFN-gamma, and increased the levels of interleukin-17, interleukin-5, interleukin-7 and PDGF. Dexmedetomidine 0-15 interleukin 18 Homo sapiens 56-70 31870428-2 2019 Reactive oxygen species (ROS) play an important role in OA development; they may activate the NLRP3 inflammasome, thereby inducing the secretion of proinflammatory IL-1beta and IL-18, leading to the aggravation of the downstream inflammatory response. Oxygen 9-15 interleukin 18 Homo sapiens 177-182 31821340-0 2019 IL-18/IL-37/IP-10 signalling complex as a potential biomarker for discriminating active and latent TB. Terbium 99-101 interleukin 18 Homo sapiens 0-5 31681274-0 2019 Targeting the Aryl Hydrocarbon Receptor With Indole-3-Aldehyde Protects From Vulvovaginal Candidiasis via the IL-22-IL-18 Cross-Talk. indole-3-carbaldehyde 45-62 interleukin 18 Homo sapiens 116-121 31819645-13 2019 The levels of LDH, IL-1beta and IL-18 of matrine combined with docetaxel-treated DU145 and PC-3 cells were significantly increased, compared with the untreated control cells. matrine 41-48 interleukin 18 Homo sapiens 32-37 31514535-5 2019 We found that cilostazol significantly reduced NLRP3 inflammasome activation, as well as the activity of other related and harmful factors, including oxidative stress, expression of NADPH oxidase 4 (NOX-4), thioredoxin-interacting protein (TxNIP), high mobility group box 1 (HMGB-1), interleukin 1beta (IL-1beta) and IL-18. Cilostazol 14-24 interleukin 18 Homo sapiens 317-322 31707403-10 2019 The expressions of uric acid-induced inflammatory markers IL-1ss and IL-18 were decreased by the inhibitor MCC950. Uric Acid 19-28 interleukin 18 Homo sapiens 69-74 31652453-10 2019 NLRP3 inflammatory body and TXNIP were activated by ketamine, which was supported by the changes in TNF-alpha, IL-6, IL-1 and IL-18 in vivo and in vitro. Ketamine 52-60 interleukin 18 Homo sapiens 126-131 30945564-9 2019 Consequently, vildagliptin inhibits production of two cytokines that are favored by NLRP3 inflammasome machinery: IL-1beta and IL-18. Vildagliptin 14-26 interleukin 18 Homo sapiens 127-132 31485636-10 2019 It was also observed that curcumin treatment downregulated the expression levels of TXNIP, NLRP3, interleukin (IL)-1beta and IL-18, and downstream caspase-1 compared with PQ treatment alone. Curcumin 26-34 interleukin 18 Homo sapiens 125-130 31827916-9 2019 Further results indicated that MMC can inhibit the activation of the NLRP3 inflammatory signalling pathway and thus downregulate the expression of downstream molecules, including IL-18 and IL-1beta. Mitomycin 31-34 interleukin 18 Homo sapiens 179-184 31521245-7 2019 Additionally, we also observed that N-Acetylcysteine (NAC, a ROS scavenger) pretreatment inhibited NLRP3 inflammasome activation as evidenced by suppressing the upregulation of NLRP3, ASC, cleaved-caspase-1, GSDMD-N, IL-1beta and IL-18 protein levels in CSE-treated ECs. Acetylcysteine 36-52 interleukin 18 Homo sapiens 230-235 31521245-7 2019 Additionally, we also observed that N-Acetylcysteine (NAC, a ROS scavenger) pretreatment inhibited NLRP3 inflammasome activation as evidenced by suppressing the upregulation of NLRP3, ASC, cleaved-caspase-1, GSDMD-N, IL-1beta and IL-18 protein levels in CSE-treated ECs. Acetylcysteine 54-57 interleukin 18 Homo sapiens 230-235 33693087-7 2019 In macrophages, MSU activates the NLRP3 inflammasome and proteolytic processing mediated by caspase-1 with enhanced interleukin (IL)-1beta and IL-18 secretion. Uric Acid 16-19 interleukin 18 Homo sapiens 143-148 31445005-5 2019 METHODS AND RESULTS: In vitro and in vivo experiments showed that DOX treatment induced cardiomyocyte pyroptosis as evidenced by increased cell death and upregulated expression levels of NLR family pyrin domain containing 3 (NLRP3), caspase-3, IL-1beta, IL-18 and GMDSD-N. Doxorubicin 66-69 interleukin 18 Homo sapiens 254-259 31593741-9 2019 Kidney TWEAK, IL-18, IL-1beta, TNF-alpha, NF-kappaB, Caspase 3 and Bax contents significantly decreased upon nilotinib administration while, kidney contents of Bcl2 and HSP-70 significantly increased. nilotinib 109-118 interleukin 18 Homo sapiens 14-19 31681274-9 2019 Administration of the microbial metabolite indole-3-aldehyde, known to stimulate the production of IL-22 via the aryl hydrocarbon receptor (AhR), promoted IL-18 expression and protection against Candida infection. indole-3-carbaldehyde 43-60 interleukin 18 Homo sapiens 155-160 31632394-7 2019 Macrophage response to nigericin was examined by RT gene profiling and subsequent qPCR, which demonstrated altered expression of a series of genes involved in the IL-18 bacterial killing pathway. Nigericin 23-32 interleukin 18 Homo sapiens 163-168 31736573-7 2019 The mean serum levels of IL-18 in MS patients and healthy individuals were 341.56 +- 39.22 Pg/Ml and 146.52 +- 29.30 Pg/Ml, respectively (P < 0.001). Minor Lymphocyte Stimulatory Antigens 94-96 interleukin 18 Homo sapiens 25-30 31736573-7 2019 The mean serum levels of IL-18 in MS patients and healthy individuals were 341.56 +- 39.22 Pg/Ml and 146.52 +- 29.30 Pg/Ml, respectively (P < 0.001). Minor Lymphocyte Stimulatory Antigens 120-122 interleukin 18 Homo sapiens 25-30 31302424-3 2019 Nucleotide-binding domain and leucine-rich-repeat-containing family pyrin 3 (NLRP3) inflammasome as a multi-protein complex that activates caspase-1 can give rise to the proinflammatory cytokines such as interleukin-18 (IL-18) and interleukin-1 beta (IL-1beta) maturation. Leucine 30-37 interleukin 18 Homo sapiens 204-218 31302424-3 2019 Nucleotide-binding domain and leucine-rich-repeat-containing family pyrin 3 (NLRP3) inflammasome as a multi-protein complex that activates caspase-1 can give rise to the proinflammatory cytokines such as interleukin-18 (IL-18) and interleukin-1 beta (IL-1beta) maturation. Leucine 30-37 interleukin 18 Homo sapiens 220-225 31473434-7 2019 We found high glucose could increase Propidium Iodide (PI) positive cells and elevate release of lactate dehydrogenase (LDH), Interleukin 1 beta (IL-1beta) and Interleukin 18 (IL-18); protein levels of GSDMD, GSDMD N-terminal domain (GSDMD-N) and cleaved-caspase-1 were also elevated. Glucose 14-21 interleukin 18 Homo sapiens 160-174 31473434-7 2019 We found high glucose could increase Propidium Iodide (PI) positive cells and elevate release of lactate dehydrogenase (LDH), Interleukin 1 beta (IL-1beta) and Interleukin 18 (IL-18); protein levels of GSDMD, GSDMD N-terminal domain (GSDMD-N) and cleaved-caspase-1 were also elevated. Glucose 14-21 interleukin 18 Homo sapiens 176-181 31276767-1 2019 We previously demonstrated that based on their potency, contact allergens differently modulate Blimp-1/NLRP12 expression in human keratinocytes, with the extreme allergen 2,4-dinitrochlorobenzene (DNCB) more rapidly upregulating Blimp-1, leading to downregulation of NLRP12, and to the production of interleukin-18 (IL-18). Dinitrochlorobenzene 171-195 interleukin 18 Homo sapiens 300-314 31429348-0 2019 Mycophenolic acid enhanced lipopolysaccharide-induced interleukin-18 release in THP-1 cells via activation of the NLRP3 inflammasome. Mycophenolic Acid 0-17 interleukin 18 Homo sapiens 54-68 31429348-3 2019 Mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil (MMF), in association with lipopolysaccharide (LPS), is able to promote the secretion of IL-18, but the mechanism remains unknown. Mycophenolic Acid 0-17 interleukin 18 Homo sapiens 161-166 31429348-3 2019 Mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil (MMF), in association with lipopolysaccharide (LPS), is able to promote the secretion of IL-18, but the mechanism remains unknown. Mycophenolic Acid 19-22 interleukin 18 Homo sapiens 161-166 31243816-5 2019 In addition, DEX prevented nuclear factor-kappa B (NF-kappaB) activation and I-kappa B (IkappaB) phosphorylation, as well as the expressions of NLRP3 inflammasome-associated protein and downstream IL-18 and IL-1beta. Dexmedetomidine 13-16 interleukin 18 Homo sapiens 197-202 31524270-5 2019 The results revealed that emodin attenuated ATP-induced HPDE6-C7 cell injury by decreasing the levels of inflammatory factors, including interleukin (IL)-1beta and IL-18. Adenosine Triphosphate 44-47 interleukin 18 Homo sapiens 164-169 31429348-3 2019 Mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil (MMF), in association with lipopolysaccharide (LPS), is able to promote the secretion of IL-18, but the mechanism remains unknown. Mycophenolic Acid 50-71 interleukin 18 Homo sapiens 161-166 31429348-3 2019 Mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil (MMF), in association with lipopolysaccharide (LPS), is able to promote the secretion of IL-18, but the mechanism remains unknown. Mycophenolic Acid 73-76 interleukin 18 Homo sapiens 161-166 31429348-9 2019 Ac-YVAD-cmk or increasing extracellular K+ blocked the activation of caspase-1 and attenuated the release of IL-18. ac-yvad 0-7 interleukin 18 Homo sapiens 109-114 31276767-1 2019 We previously demonstrated that based on their potency, contact allergens differently modulate Blimp-1/NLRP12 expression in human keratinocytes, with the extreme allergen 2,4-dinitrochlorobenzene (DNCB) more rapidly upregulating Blimp-1, leading to downregulation of NLRP12, and to the production of interleukin-18 (IL-18). Dinitrochlorobenzene 171-195 interleukin 18 Homo sapiens 316-321 30803749-9 2019 The magnitude of increase in serum IL-18 (DeltaIL-18) was significantly less in participants in the omega3FA treatment group compared to placebo (P = .047). deltail 42-49 interleukin 18 Homo sapiens 35-40 31411318-5 2019 In this study, we treated hESCs with lipopolysaccharide (LPS) and found that LPS treatment increased the mRNA levels of pro-inflammatory cytokines, such as interleukin (IL)-1beta, IL-6, IL-8, IL-18, and TNFalpha, and the secretion of IL-6. hescs 26-31 interleukin 18 Homo sapiens 192-197 31516856-0 2019 Curcumin effects on myeloperoxidase, interleukin-18 and matrix metalloproteinase-9 inflammatory biomarkers in patients with unstable angina: A randomized clinical trial. Curcumin 0-8 interleukin 18 Homo sapiens 37-51 30803749-0 2019 The Effects of OMEGA-3 Fatty Acid Supplementation Upon Interleukin-12 and Interleukin-18 in Chronic Kidney Disease Patients. Fatty Acids, Omega-3 15-33 interleukin 18 Homo sapiens 74-88 30692654-11 2019 Tamoxifen decreased breast tissue levels of IL-8 and IL-18. Tamoxifen 0-9 interleukin 18 Homo sapiens 53-58 30803749-9 2019 The magnitude of increase in serum IL-18 (DeltaIL-18) was significantly less in participants in the omega3FA treatment group compared to placebo (P = .047). Fatty Acids, Omega-3 100-108 interleukin 18 Homo sapiens 35-40 30803749-10 2019 CONCLUSION(S): This study has shown that 4 g daily omega3FA supplementation may lower serum IL-18 levels in patients with moderate CKD. Fatty Acids, Omega-3 51-59 interleukin 18 Homo sapiens 92-97 31423543-8 2019 The results showed that the treatment with PA increased IL-18 and TNF-alpha production. Palmitic Acid 43-45 interleukin 18 Homo sapiens 56-61 31302140-7 2019 Notably, dulaglutide treatment suppressed high glucose- induced maturation of IL-1beta and IL-18. Glucose 47-54 interleukin 18 Homo sapiens 91-96 31423543-9 2019 Contrariwise, the supplementation with DHA reduced IL-18, TNF-alpha and PAI-1 secretion by macrophages. Docosahexaenoic Acids 39-42 interleukin 18 Homo sapiens 51-56 31418380-9 2019 The expression level of IL-17 and IL-18 in PBMNC of the ITP patients in newly diagnosed group was higher than that in the control group and the remission group(P<0. Inosine Triphosphate 56-59 interleukin 18 Homo sapiens 34-39 30982734-0 2019 Choline Uptake and Metabolism Modulate Macrophage IL-1beta and IL-18 Production. Choline 0-7 interleukin 18 Homo sapiens 63-68 31427887-11 2019 In addition, anti-mouse IL-18-neutralizing monoclonal antibodies (anti-IL-18 nAb) inhibited angiotensin II-induced M1 macrophage differentiation and SMC apoptosis in vitro. nab 77-80 interleukin 18 Homo sapiens 24-29 31427887-11 2019 In addition, anti-mouse IL-18-neutralizing monoclonal antibodies (anti-IL-18 nAb) inhibited angiotensin II-induced M1 macrophage differentiation and SMC apoptosis in vitro. nab 77-80 interleukin 18 Homo sapiens 71-76 31357788-3 2019 Under the influence of ethanol, the damaged hepatocyte release uric acid, and adenosine triphosphate and induces NLRP3 inflammasome assembly and functional activation in Kupffer cells to promote the release of inflammatory mediators, such as interleukin-1beta and interleukin-18, that cascade mediates inflammation and drive alcoholic liver disease from steatosis to inflammation and fibrosis. Ethanol 23-30 interleukin 18 Homo sapiens 264-278 31357788-3 2019 Under the influence of ethanol, the damaged hepatocyte release uric acid, and adenosine triphosphate and induces NLRP3 inflammasome assembly and functional activation in Kupffer cells to promote the release of inflammatory mediators, such as interleukin-1beta and interleukin-18, that cascade mediates inflammation and drive alcoholic liver disease from steatosis to inflammation and fibrosis. Uric Acid 63-72 interleukin 18 Homo sapiens 264-278 31357788-3 2019 Under the influence of ethanol, the damaged hepatocyte release uric acid, and adenosine triphosphate and induces NLRP3 inflammasome assembly and functional activation in Kupffer cells to promote the release of inflammatory mediators, such as interleukin-1beta and interleukin-18, that cascade mediates inflammation and drive alcoholic liver disease from steatosis to inflammation and fibrosis. Adenosine Triphosphate 78-100 interleukin 18 Homo sapiens 264-278 31475210-8 2019 The inflammatory factors of interleukin-18, tumor necrosis factor-alpha, and the levels of neutrophil gelatinase-associated lipocalin (NGAL) were lower in sevoflurane group, while no oxidative stress factors [hydrogen peroxide (H2O2), malondialdehyde and superoxide dismutase)] and interleukin-10 showed differences between the groups. Sevoflurane 155-166 interleukin 18 Homo sapiens 28-71 31427887-8 2019 Plasma IL-18, IFN-gamma, and IL-6 levels were significantly higher in the AD group than in the NAD group, and the IL-18 levels were positively correlated with the IFN-gamma and IL-6 levels. nadide 95-98 interleukin 18 Homo sapiens 114-119 31593848-7 2019 Moreover, serum suPAR and IL-18 levels were negatively correlated with eGFR (rho = -0.734, rho = -0.462, p <0.01) and positively correlated with the urine protein to creatinine ratio (UP/CR) (rho = 0.730, rho = 0.440, p <0.01). Creatinine 169-179 interleukin 18 Homo sapiens 26-31 31360100-5 2019 We found that caffeine significantly reduced NLRP3 expression, ASC speck formation, and caspase 1 cleavage and therefore decreased IL-1beta and IL-18 secretion in THP-1 macrophages. Caffeine 14-22 interleukin 18 Homo sapiens 144-149 31156213-8 2019 The matrine treatment reduced intracellular ROS level and supernatant IL18 and TNFalpha concentrations and increased TAC in a concentration- dependent manner. matrine 4-11 interleukin 18 Homo sapiens 70-74 31156213-10 2019 Moreover, the expression levels of IL18 and TNFalpha were also decreased by matrine treatment, in a concentration-dependent manner. matrine 76-83 interleukin 18 Homo sapiens 35-39 31178664-5 2019 The results demonstrate that compared with the low-glucose culture, high glucose triggered higher cell death and increased IL-18 and IL-1beta mRNA expression and protein production. Glucose 73-80 interleukin 18 Homo sapiens 123-128 31139563-0 2019 Antitumor Effects of Berberine on Gliomas via Inactivation of Caspase-1-Mediated IL-1beta and IL-18 Release. Berberine 21-30 interleukin 18 Homo sapiens 94-99 31139563-6 2019 In this study, we demonstrate that berberine significantly inhibits inflammatory cytokine Caspase-1 activation via ERK1/2 signaling and subsequent production of IL-1beta and IL-18 by glioma cells. Berberine 35-44 interleukin 18 Homo sapiens 174-179 31172009-6 2019 Results: In HT-29 cells, PTPN2 depletion resulted in enhanced mRNA expression of PTPN11 and PTPN23 and in parallel to upregulation of IL-18 mRNA upon treatment with TNF for 24 h. DSS treatment of PTPN2-deficient mice resulted in a strong induction of Ptpn23 mRNA in colon tissue in vivo. Dextran Sulfate 179-182 interleukin 18 Homo sapiens 134-139 30958608-7 2019 In addition, DEX suppressed the generation of TNF-alpha, IL-1beta, and IL-18 as well as the phosphorylation of ERK1/2 and P38. Dexmedetomidine 13-16 interleukin 18 Homo sapiens 71-76 30706178-8 2019 Phosphate treatment increased SGK1 and osteogenic markers mRNA expression as well as ALPL activity and induced calcification of HAoSMCs, all effects significantly augmented by additional treatment with IL-18. Phosphates 0-9 interleukin 18 Homo sapiens 202-207 30706178-11 2019 In conclusion, SGK1 expression is upregulated by IL-18 in VSMCs and SGK1 participates in the intracellular signaling of IL-18-induced osteo-/chondrogenic transdifferentiation of VSMCs. vsmcs 58-63 interleukin 18 Homo sapiens 49-54 31164964-0 2019 H2S mediates increased interleukin (IL)-1beta and IL-18 production in leukocytes from patients with periodontitis. Hydrogen Sulfide 0-3 interleukin 18 Homo sapiens 50-55 31164964-2 2019 Aim: To investigate the effect of the bacterial metabolite H2S on the pro-inflammatory cytokines interleukin (IL)-1beta and IL-18 from periodontitis patients and healthy controls, and to evaluate the composition of the subgingival microbiota with its capacity to produce H2S. Hydrogen Sulfide 59-62 interleukin 18 Homo sapiens 124-129 31164964-6 2019 PBMCs exposed to H2S secreted significantly more IL-1ss and IL-18 (p<0.0001) than untreated control PBMCs from both groups. Hydrogen Sulfide 17-20 interleukin 18 Homo sapiens 60-65 31164964-7 2019 PBMCs from the periodontitis patients secreted higher levels of the cytokines, both spontaneously (IL-1ss p=0.0001; IL-18 p=0.09) and after exposure to H2S (IL-1ss p=0.03; IL-18 p=0.04), which is a new finding not previously reported. Hydrogen Sulfide 152-155 interleukin 18 Homo sapiens 116-121 31164964-7 2019 PBMCs from the periodontitis patients secreted higher levels of the cytokines, both spontaneously (IL-1ss p=0.0001; IL-18 p=0.09) and after exposure to H2S (IL-1ss p=0.03; IL-18 p=0.04), which is a new finding not previously reported. Hydrogen Sulfide 152-155 interleukin 18 Homo sapiens 172-177 31164964-8 2019 Conclusions: H2S, from the subgingival microbiota, can contribute to a host inflammatory response through secretion of the pro-inflammatory cytokines IL-1beta and IL-18. Hydrogen Sulfide 13-16 interleukin 18 Homo sapiens 163-168 30803848-6 2019 SLE patients exhibit increased levels of ATP which binds to P2X receptors resulting in activation of the inflammasome and consequent release of IL-1beta and IL-18, cytokines associated with disease pathogenesis. Adenosine Triphosphate 41-44 interleukin 18 Homo sapiens 157-162 30962589-6 2019 In monocytes, formation of GSDMD pores can induce activation of the NLRP3 inflammasome for maturation of the cytokines IL-1beta and IL-18. gsdmd 27-32 interleukin 18 Homo sapiens 132-137 31178966-13 2019 IL-18, and BUN biomarkers in the deferasirox group were significantly higher than those in the control group (p < 0.001). Deferasirox 33-44 interleukin 18 Homo sapiens 0-5 30833078-4 2019 RESULTS: U937 macrophages treated with MSU crystals showed increased expression of IL-1beta, IL-18, caspase-1, and TXNIP and activation of NF-kappaB signaling, which were strongly inhibited by addition of antioxidants or transfection with TXNIP siRNA. Uric Acid 39-42 interleukin 18 Homo sapiens 93-98 31178664-7 2019 Notably, NAC, a ROS scavenger, could attenuate high glucose-induced ROS formation and IL-18 and IL-1beta mRNA and protein expression and block inflammasome activation. Acetylcysteine 9-12 interleukin 18 Homo sapiens 86-91 31178664-7 2019 Notably, NAC, a ROS scavenger, could attenuate high glucose-induced ROS formation and IL-18 and IL-1beta mRNA and protein expression and block inflammasome activation. ros 16-19 interleukin 18 Homo sapiens 86-91 31178664-7 2019 Notably, NAC, a ROS scavenger, could attenuate high glucose-induced ROS formation and IL-18 and IL-1beta mRNA and protein expression and block inflammasome activation. Glucose 52-59 interleukin 18 Homo sapiens 86-91 31178664-9 2019 Intrudingly, H2S could ameliorate high glucose-induced ROS formation, IL-18 and IL-1beta expression, and inflammasome activation. Deuterium 13-16 interleukin 18 Homo sapiens 70-75 31178664-9 2019 Intrudingly, H2S could ameliorate high glucose-induced ROS formation, IL-18 and IL-1beta expression, and inflammasome activation. Glucose 39-46 interleukin 18 Homo sapiens 70-75 30962733-8 2019 Ginsenosides have also been shown to inhibit caspase-1 and to decrease the expression of IL-1beta and IL-18. Ginsenosides 0-12 interleukin 18 Homo sapiens 102-107 30992532-0 2019 An innate interaction between IL-18 and the propeptide that inactivates its precursor form. propeptide 44-54 interleukin 18 Homo sapiens 30-35 30992532-2 2019 Here we report an intramolecular interaction between IL-18 and its propeptide, which is proteolytically removed from its precursor proIL-18 during maturation. propeptide 67-77 interleukin 18 Homo sapiens 53-58 30992532-2 2019 Here we report an intramolecular interaction between IL-18 and its propeptide, which is proteolytically removed from its precursor proIL-18 during maturation. proil 131-136 interleukin 18 Homo sapiens 53-58 30958862-6 2019 Stimulation with LPS resulted in IL-1beta release; however, addition of ATP is necessary for "full-blown" inflammasome stimulation resulting in high IL-1beta and IL-18 release. Adenosine Triphosphate 72-75 interleukin 18 Homo sapiens 162-167 30997045-6 2019 Serum IL-18 was significantly negatively correlated with both carbon monoxide transfer coefficient (KCO) and diffusing capacity of the lungs for carbon monoxide (DLCO). Carbon Monoxide 62-77 interleukin 18 Homo sapiens 6-11 30997045-6 2019 Serum IL-18 was significantly negatively correlated with both carbon monoxide transfer coefficient (KCO) and diffusing capacity of the lungs for carbon monoxide (DLCO). Carbon Monoxide 145-160 interleukin 18 Homo sapiens 6-11 30783732-5 2019 Adjusted for age, the mometasone-treated group decreased the concentration of CXCL9, CXCL11, CD40, IL-10, and IL-18 relative to placebo-treated participants. Mometasone Furoate 22-32 interleukin 18 Homo sapiens 110-115 30911044-8 2019 At the level of signal transduction, genistein decreases IL-12/IL-18-induced total phosphorylated tyrosine, and phosphorylation MAPK pathway components. Genistein 37-46 interleukin 18 Homo sapiens 63-68 30925760-7 2019 Stratifying the population according to smoking, alcohol drinking, hypertension, and diabetes status revealed a different distribution of IL-18 -607 genotypes among non-smokers, non-drinkers, and patients without diabetes, but not among smokers, drinkers, or patients with diabetes. Alcohols 49-56 interleukin 18 Homo sapiens 138-143 30911044-8 2019 At the level of signal transduction, genistein decreases IL-12/IL-18-induced total phosphorylated tyrosine, and phosphorylation MAPK pathway components. Tyrosine 98-106 interleukin 18 Homo sapiens 63-68 30911044-9 2019 Further, genistein limits IL-12/IL-18-mediated upregulation of IL-18Ralpha expression on NK cells (p = 0.0109). Genistein 9-18 interleukin 18 Homo sapiens 32-37 30696773-5 2019 Notably, treatment of IL-18-stimulated NK cells with leucine activates the metabolic sensor mTORC1, indicating that the high expression of amino acid transporters induces amino acid-driven mTORC1 activation. Leucine 53-60 interleukin 18 Homo sapiens 22-27 30628668-5 2019 The overexpression of miRNA-20b increased the levels of IL-1beta and IL-18 in the cerebral ischemia group through activation of the NLRP3 signaling pathway. mirna-20b 22-31 interleukin 18 Homo sapiens 69-74 30647128-4 2019 We demonstrate that the more potent analogue 11-oxo-12S-hydroxylithocholic acid methyl ester (BAA473) can induce secretion of interleukin-18 (IL-18) through activation of the inflammasome in both myeloid and intestinal epithelial cells. 11-oxo-12s-hydroxylithocholic acid methyl ester 45-92 interleukin 18 Homo sapiens 126-140 30647128-4 2019 We demonstrate that the more potent analogue 11-oxo-12S-hydroxylithocholic acid methyl ester (BAA473) can induce secretion of interleukin-18 (IL-18) through activation of the inflammasome in both myeloid and intestinal epithelial cells. 11-oxo-12s-hydroxylithocholic acid methyl ester 45-92 interleukin 18 Homo sapiens 142-147 30647128-4 2019 We demonstrate that the more potent analogue 11-oxo-12S-hydroxylithocholic acid methyl ester (BAA473) can induce secretion of interleukin-18 (IL-18) through activation of the inflammasome in both myeloid and intestinal epithelial cells. baa473 94-100 interleukin 18 Homo sapiens 126-140 30647128-4 2019 We demonstrate that the more potent analogue 11-oxo-12S-hydroxylithocholic acid methyl ester (BAA473) can induce secretion of interleukin-18 (IL-18) through activation of the inflammasome in both myeloid and intestinal epithelial cells. baa473 94-100 interleukin 18 Homo sapiens 142-147 30628668-6 2019 Conversely, the downregulation of miRNA-20b suppressed IL-1beta and IL-18 levels in cerebral ischemia via suppression of the NLRP3 signaling pathway. mirna-20b 34-43 interleukin 18 Homo sapiens 68-73 30638709-6 2019 Treatment ex vivo with TPC decreased the production of IL-1beta, IL-2, IL-5, IL-6, IL-9, IL-12(p70), IL-13, IL-17A, IL-18, IL-21, IL-22, IL-23, IFNgamma, TNFalpha, GM-CSF by CD3/CD28 activated PBMCs whereas it negligibly affected cell viability. tpc 23-26 interleukin 18 Homo sapiens 116-121 30638709-9 2019 The effects of TPC were comparable to the effects of dexamethasone, included as the standard of care, with the exception of a greater reduction of IL-2, IL-18, IFNgamma in CD3/CD28 activated PBMCs and CD68 gene in inflamed TABs. tpc 15-18 interleukin 18 Homo sapiens 153-158 30628671-5 2019 The results of the present study demonstrated that caspase-1 activity, interleukin (IL)-1beta and IL-18 were upregulated in patients with RSA compared with healthy controls. rabbit sperm membrane autoantigen 138-141 interleukin 18 Homo sapiens 98-103 30519866-7 2019 Our data show that dopamine treatment of human macrophages isolated from healthy and cART-treated donors promotes production of inflammatory mediators including IL-1beta, IL-6, IL-18, CCL2, CXCL8, CXCL9, and CXCL10. Dopamine 19-27 interleukin 18 Homo sapiens 177-182 30906223-9 2019 Meanwhile, NPS2143, BAY 11-7082, and INF39 could significantly abolish the high glucose-enhanced NLRP3, ASC, caspase-1, IL-18, and IL-1beta expression in vitro. Glucose 80-87 interleukin 18 Homo sapiens 120-125 30660990-8 2019 Also, ELISA results demonstrate that anagliptin treatment significantly abolished high glucose- induced maturation of IL-1beta and IL-18. anagliptin 37-47 interleukin 18 Homo sapiens 131-136 30660990-8 2019 Also, ELISA results demonstrate that anagliptin treatment significantly abolished high glucose- induced maturation of IL-1beta and IL-18. Glucose 87-94 interleukin 18 Homo sapiens 131-136 30611759-9 2019 In addition, western blot and real-time PCR analysis revealed that VPA modulated the protein expression of apoptosis repressor with caspase recruitment domain (ARC), caspase-1 and IL-1beta/IL-18. Valproic Acid 67-70 interleukin 18 Homo sapiens 189-194 30906223-7 2019 The results showed that high glucose increased the expression of interleukin-18 (IL-18), interleukin-1beta (IL-1beta), NLRP3, caspase-1, and ASC, as well as the protein level of TLR4, nucleus p65, and CaSR. Glucose 29-36 interleukin 18 Homo sapiens 65-79 30906223-10 2019 In addition, both NPS2143 and BAY 11-7082 attenuated high glucose-induced upregulation of NLRP3, ASC, caspase-1, IL-18, and IL-1beta expression. 3-(4-methylphenylsulfonyl)-2-propenenitrile 30-41 interleukin 18 Homo sapiens 113-118 30906223-7 2019 The results showed that high glucose increased the expression of interleukin-18 (IL-18), interleukin-1beta (IL-1beta), NLRP3, caspase-1, and ASC, as well as the protein level of TLR4, nucleus p65, and CaSR. Glucose 29-36 interleukin 18 Homo sapiens 81-86 30906223-10 2019 In addition, both NPS2143 and BAY 11-7082 attenuated high glucose-induced upregulation of NLRP3, ASC, caspase-1, IL-18, and IL-1beta expression. Glucose 58-65 interleukin 18 Homo sapiens 113-118 30736871-9 2019 All three serum markers of AKI (cystatin C, NGAL, and IL-18) studied were positively correlated with OSA severity, and two (cystatin C and IL-18) were positively correlated with the frequency of oxygen desaturation during sleep. Oxygen 195-201 interleukin 18 Homo sapiens 139-144 30717382-6 2019 Furthermore, together with IL-3, IL-18 stimulates mast cells and basophils to produce IL-4, IL-13, and chemical mediators such as histamine. Histamine 130-139 interleukin 18 Homo sapiens 33-38 30089853-0 2018 Remifentanil upregulates hepatic IL-18 binding protein (IL-18BP) expression through transcriptional control. Remifentanil 0-12 interleukin 18 Homo sapiens 33-38 30058723-4 2019 When longitudinal kinetics of biomarkers and tumor size were modeled, tumor shrinkage was found to significantly correlate with area under the curve (AUC), baseline factors (metastatic sites, liver metastases, and smoking status), and relative change in interleukin (IL)-18 level from baseline at day 21 (RCFBIL -18,d21 ). rcfbil 305-311 interleukin 18 Homo sapiens 254-273 30601517-6 2019 The results showed that GABA supplementation improved the growth performance and modulated the intestinal immunity with inhibiting the gene expressions of IL-22, proinflammatory cytokines (IL-1 and IL-18), and Muc1, but promoted the expressions of anti-inflammatory cytokines (IFN-gamma, IL-4, and IL-10), TLR6 and MyD88. gamma-Aminobutyric Acid 24-28 interleukin 18 Homo sapiens 198-203 30660185-9 2019 BMI SDS trajectory was associated with high-density lipoprotein-cholesterol and interleukin-18 (IL-18) in males, and diastolic blood pressure and interleukin-6 (IL-6) in females. sds 4-7 interleukin 18 Homo sapiens 80-94 30660185-9 2019 BMI SDS trajectory was associated with high-density lipoprotein-cholesterol and interleukin-18 (IL-18) in males, and diastolic blood pressure and interleukin-6 (IL-6) in females. sds 4-7 interleukin 18 Homo sapiens 96-101 30522955-5 2019 Notably, the novel pseudotripeptides influenced inflammatory cytokine expression (IL-1beta, IL-18, and TNF-alpha) in Abeta25-35-, PMA-, and LPS-treated THP-1 cells. pseudotripeptides 19-36 interleukin 18 Homo sapiens 92-97 30522955-5 2019 Notably, the novel pseudotripeptides influenced inflammatory cytokine expression (IL-1beta, IL-18, and TNF-alpha) in Abeta25-35-, PMA-, and LPS-treated THP-1 cells. Tetradecanoylphorbol Acetate 130-133 interleukin 18 Homo sapiens 92-97 30392846-6 2019 IL-18 levels correlated positively with bilirubin, INR, ALT and AST levels, and negatively with albumin levels and erythrocyte count. Bilirubin 40-49 interleukin 18 Homo sapiens 0-5 30246263-7 2019 Meanwhile, treating the cells with sodium hydrosulfide (NaHS) inhibited the productions of IL-1beta and IL-18. sodium bisulfide 35-54 interleukin 18 Homo sapiens 104-109 30246263-7 2019 Meanwhile, treating the cells with sodium hydrosulfide (NaHS) inhibited the productions of IL-1beta and IL-18. sodium bisulfide 56-60 interleukin 18 Homo sapiens 104-109 31258598-1 2019 Background & Objectives: The hallmark of rheumatoid arthritis is the inflammation that is mediated by the macrophages and monocytes that cause release of pro-inflammatory cytokines like interleukin-18. Adenosine Monophosphate 12-15 interleukin 18 Homo sapiens 190-204 30404814-7 2018 LPS or nigericin stimulation of PLAC8-overexpressing human monocytic cell line (THP-1), but not mock THP-1 cells, was associated with a significant decrease in IL-1beta and IL-18 production. Nigericin 7-16 interleukin 18 Homo sapiens 173-178 30726812-6 2019 Furthermore, the protein expression of pyroptosis (Cleaved Caspase-1, NO, IL-1beta, IL-18), as well as LDH and the relative electrical conductivity were significantly augmented by BaP. benzylaminopurine 180-183 interleukin 18 Homo sapiens 84-89 30442667-5 2018 Furthermore, CD8+ MAIT cells have higher levels of receptors for IL-12 and IL-18, as well as of the activating receptors CD2, CD9, and NKG2D, and display superior functionality following stimulation with riboflavin-autotrophic as well as riboflavin-auxotrophic bacterial strains. Riboflavin 204-214 interleukin 18 Homo sapiens 75-80 30089853-2 2018 We have previously demonstrated that remifentanil protects against liver I/R injury by upregulating the hepatic expression of IL-18-binding protein (IL-18BP), a natural IL-18 inhibitor. Remifentanil 37-49 interleukin 18 Homo sapiens 126-131 30089853-6 2018 In LO2 cells, preexposure of the cells to remifentanil significantly inhibited IL-18-activated p65 NF-kappaB phosphorylation, and the inhibition was absent when the cells were transfected with IL-18BP siRNA, indicating the functional effects of IL-18BP induced by remifentanil. Remifentanil 42-54 interleukin 18 Homo sapiens 79-84 30089853-6 2018 In LO2 cells, preexposure of the cells to remifentanil significantly inhibited IL-18-activated p65 NF-kappaB phosphorylation, and the inhibition was absent when the cells were transfected with IL-18BP siRNA, indicating the functional effects of IL-18BP induced by remifentanil. Remifentanil 264-276 interleukin 18 Homo sapiens 79-84 30455639-8 2018 Following homotaurine supplementation, patients carrying the APOEepsilon4 allele showed a significant decrease in IL-18 (both in its total and IL-18BP unbound forms), in turn associated with improved short-term episodic memory performance as measured by the recency effect of the Rey 15-word list learning test immediate recall. tramiprosate 10-21 interleukin 18 Homo sapiens 114-119 30205151-4 2018 In addition, exposure to acrolein resulted in NLRP3 inflammasome activation as evidenced by cleavage of caspase-1 and downstream mature interleukin (IL)-1beta and IL-18 secretion. Acrolein 25-33 interleukin 18 Homo sapiens 163-168 30527256-13 2018 Levels of IL-18 correlated with glucose, HbA1c and lipids, but not with body mass index, insulin or blood pressure. Glucose 32-39 interleukin 18 Homo sapiens 10-15 30341522-10 2018 WISP1 can be involved in glucose/lipid metabolism in obese youth, which may be modulated by IL-18. Glucose 25-32 interleukin 18 Homo sapiens 92-97 30344684-0 2018 Clinical effects of tanshinone IIA sodium sulfonate combined with trimetazidine and levocarnitine in the treatment of AVMC and its effects on serum TNF-alpha, IL-18 and IL-35. tanshinone II A sodium sulfonate 20-51 interleukin 18 Homo sapiens 159-164 30286362-9 2018 In patients successfully pregnant under Intralipid who benefitted of a test of sensibility before the embryo transfer, we observed a significant decrease of the three biomarkers used to diagnose the over-immune endometrial activation (CD56 cells; IL-18/TWEAK, IL-14/FN-14). soybean oil, phospholipid emulsion 40-50 interleukin 18 Homo sapiens 248-253 30341285-4 2018 In this study we demonstrated, for the first time, that both Euro 4 and Euro 5 carbon particles, deprived of PAHs possibly adsorbed on the soot surface, were able to: (1) significantly affect cell viability, inducing autophagy, apoptosis and necrosis; (2) stimulate the release of the pro-inflammatory cytokine IL-18; (3) elicit protein citrullination and PAD activity in NHBE cells. Carbon 79-85 interleukin 18 Homo sapiens 311-316 29105345-7 2018 RESULTS: Our results demonstrated that treatment with LPS and ATP increased significantly both in mRNA and protein levels of all the NLRP3 inflammasome components, and triggered the NLRP3 inflammasome, followed by upregulated IL-1beta and IL-18 in the cell supernatant. Adenosine Triphosphate 62-65 interleukin 18 Homo sapiens 239-244 30464617-9 2018 After substratification of the subjects according to their smoking, alcohol consumption, and areca chewing status, the genotype distribution of the IL-18-607 polymorphism was found to be different only among nonsmokers between the NPC and control subgroups. Alcohols 68-75 interleukin 18 Homo sapiens 148-153 30236988-7 2018 Plasma IL-18 levels were significantly positively associated with Child-Pugh classification, IL-1beta levels, diastolic blood pressure, aspartate aminotransferase, total bilirubin, direct bilirubin, activated partial thromboplastin timealk and aline phosphatase. Bilirubin 170-179 interleukin 18 Homo sapiens 7-12 30236988-7 2018 Plasma IL-18 levels were significantly positively associated with Child-Pugh classification, IL-1beta levels, diastolic blood pressure, aspartate aminotransferase, total bilirubin, direct bilirubin, activated partial thromboplastin timealk and aline phosphatase. Bilirubin 188-197 interleukin 18 Homo sapiens 7-12 30340555-0 2018 Possible involvement of interleukin-18 in the pathology of hepatobiliary adverse effects related to treatment with ceritinib. ceritinib 115-124 interleukin 18 Homo sapiens 24-38 30340555-6 2018 Therefore, we hypothesized that IL-18 is involved in the pathology of hepatobiliary adverse effects related to treatment with ceritinib and evaluated the serum IL-18. ceritinib 126-135 interleukin 18 Homo sapiens 32-37 30340555-11 2018 Our records showed that the levels of serum IL-18 increased from the early stage of hepatobiliary adverse effects related to the treatment with ceritinib and were became worse with an increase in hepatobiliary enzymes and the progression of imaging abnormalities in the bile duct. ceritinib 144-153 interleukin 18 Homo sapiens 44-49 30340555-13 2018 CONCLUSION: Our case report shows that the increase of serum IL-18 had a positive correlation with the progression of severe hepatobiliary adverse effects related to treatment with ceritinib and the involvement of IL-18 in the hepatobiliary inflammation by pathological evaluation. ceritinib 181-190 interleukin 18 Homo sapiens 61-66 30340555-14 2018 These results suggest that IL-18 could be a useful surrogate marker for the hepatobiliary toxicity of ceritinib. ceritinib 102-111 interleukin 18 Homo sapiens 27-32 30270565-2 2018 Our results show that the mRNA levels of IL-1beta, IL-18, NLRP3, ASC, and caspase-1 in the DSS+ZEA-treated group are lower than those in either the DSS or ZEA group, and the protein expression trends are similar. Dextran Sulfate 91-94 interleukin 18 Homo sapiens 51-56 30270565-2 2018 Our results show that the mRNA levels of IL-1beta, IL-18, NLRP3, ASC, and caspase-1 in the DSS+ZEA-treated group are lower than those in either the DSS or ZEA group, and the protein expression trends are similar. Zearalenone 95-98 interleukin 18 Homo sapiens 51-56 29857000-6 2018 In the current study, we investigated the issue of whether or how Quercetin attenuates poly (dA:dT), a synthetic analog of microbial dsDNA, -induced IL-18 secretion in IFN-gamma-primed human keratinocytes. poly 87-91 interleukin 18 Homo sapiens 149-154 29857000-0 2018 Quercetin inhibits the poly(dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-gamma-primed human keratinocytes. Quercetin 0-9 interleukin 18 Homo sapiens 56-61 30241336-7 2018 CST administration increased proliferation, viability, migration, TJ proteins, and p-STAT3 levels, and reduced IL-8 &amp; IL-18 in LPS- &amp; DSS-induced Caco2 cell epithelial injury, and the presence of STAT-3 inhibitor abolished the beneficial effect of CST. Dextran Sulfate 150-153 interleukin 18 Homo sapiens 126-131 29857000-6 2018 In the current study, we investigated the issue of whether or how Quercetin attenuates poly (dA:dT), a synthetic analog of microbial dsDNA, -induced IL-18 secretion in IFN-gamma-primed human keratinocytes. Thymidine 96-98 interleukin 18 Homo sapiens 149-154 29857000-0 2018 Quercetin inhibits the poly(dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-gamma-primed human keratinocytes. poly 23-27 interleukin 18 Homo sapiens 56-61 29857000-7 2018 Treatment with 5 and 10 muM of Quercetin inhibited the poly (dA:dT)-induced secretion of IL-18 after IFN-gamma priming and before poly (dA:dT)-induced AIM2 activation. Quercetin 31-40 interleukin 18 Homo sapiens 89-94 29857000-0 2018 Quercetin inhibits the poly(dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-gamma-primed human keratinocytes. amsonic acid 28-30 interleukin 18 Homo sapiens 56-61 29857000-7 2018 Treatment with 5 and 10 muM of Quercetin inhibited the poly (dA:dT)-induced secretion of IL-18 after IFN-gamma priming and before poly (dA:dT)-induced AIM2 activation. Poly dA-dT 55-67 interleukin 18 Homo sapiens 89-94 29857000-0 2018 Quercetin inhibits the poly(dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-gamma-primed human keratinocytes. Thymidine 31-33 interleukin 18 Homo sapiens 56-61 29857000-7 2018 Treatment with 5 and 10 muM of Quercetin inhibited the poly (dA:dT)-induced secretion of IL-18 after IFN-gamma priming and before poly (dA:dT)-induced AIM2 activation. Poly dA-dT 55-66 interleukin 18 Homo sapiens 89-94 29857000-9 2018 These results suggest that treatment with Quercetin inhibits the poly (dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-gamma-primed keratinocytes. Quercetin 42-51 interleukin 18 Homo sapiens 99-104 29857000-9 2018 These results suggest that treatment with Quercetin inhibits the poly (dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-gamma-primed keratinocytes. poly 65-69 interleukin 18 Homo sapiens 99-104 29857000-9 2018 These results suggest that treatment with Quercetin inhibits the poly (dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-gamma-primed keratinocytes. amsonic acid 71-73 interleukin 18 Homo sapiens 99-104 29857000-9 2018 These results suggest that treatment with Quercetin inhibits the poly (dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-gamma-primed keratinocytes. Thymidine 74-76 interleukin 18 Homo sapiens 99-104 29588315-11 2018 Patients with Tangier disease, who carry loss-of-function mutations in ABCA1 and have increased myeloid cholesterol content, showed a marked increase in plasma IL-1beta and IL-18 levels. Cholesterol 104-115 interleukin 18 Homo sapiens 173-178 30022770-6 2018 Multiple linear regression analysis showed that the serum creatinine and left ventricular ejection fraction were significantly effective factors influencing IL-18 (P < 0.01). Creatinine 58-68 interleukin 18 Homo sapiens 157-162 30126430-11 2018 In THP-1 cells, RIP3 and NLRP3 interaction was enhanced by LPS/ATP stimulation resulting in IL-1beta and IL-18 production. Adenosine Triphosphate 63-66 interleukin 18 Homo sapiens 105-110 29993075-8 2018 The underlying mechanism of quercetin"s benefit on the liver may be explained by its anti-oxidant properties and inhibitory effect on the ROS/NF-kappaB/NLRP3 inflammasome/IL-1beta and IL-18 pathway by inducing HO-1. Quercetin 28-37 interleukin 18 Homo sapiens 184-189 29846789-10 2018 However, IL-6, IL-12, IL-17 and IL-18 were significantly increased in pSS patients compared to controls. pss 70-73 interleukin 18 Homo sapiens 32-37 30016181-13 2018 As expected, UFH decreased LPS-induced IL-1beta, TNF-alpha, IL-6, IL-8, and IL-18 protein levels, suggesting that UFH has an anti-inflammatory effect on THP-1 cells by interrupting the MAPK, NF-kappaB, and c-Jun signaling pathways. Heparin 13-16 interleukin 18 Homo sapiens 76-81 29986752-4 2018 We report a case of adult onset Still"s disease in an older patient successfully treated with steroids in which interleukin-18 was a useful marker of disease activity. Steroids 94-102 interleukin 18 Homo sapiens 112-126 29976873-6 2018 Tianeptine attenuated microglia activation by decreasing the expression of cluster of differentiation 40 (CD40), and major histocompatibility complex class II (MHC II) markers, as well as the release of pro-inflammatory factors: interleukin (IL)-1beta, IL-18, IL-6, tumor necrosis factor alpha (TNF-alpha), and chemokine CC motif ligand 2 (CCL2), and the production of nitric oxide and reactive oxygen species. tianeptine 0-10 interleukin 18 Homo sapiens 253-258 30016181-13 2018 As expected, UFH decreased LPS-induced IL-1beta, TNF-alpha, IL-6, IL-8, and IL-18 protein levels, suggesting that UFH has an anti-inflammatory effect on THP-1 cells by interrupting the MAPK, NF-kappaB, and c-Jun signaling pathways. Heparin 114-117 interleukin 18 Homo sapiens 76-81 29684255-8 2018 Fold changes in the gene expression of ET-1, interleukin (IL) 18, and tumor necrosis factor alpha (TNF-alpha) were associated with creatinine peak value. Creatinine 131-141 interleukin 18 Homo sapiens 45-64 29724886-9 2018 We discovered that the expression of the factors was significantly increased in pterygium and that caspase-1-dependent pyroptosis presents in both H2O2-treated HPFs and HConECs during which the expression of these factors was significantly elevated and the elevation of downstream factors IL-18 and IL-1beta was restrained after caspase-1 inhibition. Hydrogen Peroxide 147-151 interleukin 18 Homo sapiens 289-294 29915579-15 2018 IFN-gamma was found to strengthen poly(dA:dT)-induced cell pyroptosis and bioactive IL-18 release. poly 34-38 interleukin 18 Homo sapiens 84-89 29168426-12 2018 Significant correlation of testosterone with IL-18 levels was not found. Testosterone 27-39 interleukin 18 Homo sapiens 45-50 29168426-13 2018 IL-18 correlated with parameters of obesity, lipids, fasting blood sugar (p < .05) and the number of criteria for MS (p < .001). Sugars 67-72 interleukin 18 Homo sapiens 0-5 30078783-6 2018 IL-18 was a potential CYP3A expression modulator and was capable of affecting tacrolimus pharmacokinetics. Tacrolimus 78-88 interleukin 18 Homo sapiens 0-5 29107116-2 2018 Studies have demonstrated that loss of autophagy/mitophagy can lead to a build-up of cytosolic reactive oxygen species and mitochondrial DNA, which can, in turn, activate immune signalling pathways that ultimately lead to the releases of inflammatory cytokines, including IL-1alpha, IL-1beta, IL-18, type I IFN and macrophage migration inhibitory factor (MIF). Reactive Oxygen Species 95-118 interleukin 18 Homo sapiens 293-298 29627619-10 2018 The IL-18/TWEAK mRNA ratio reflecting the Th-1/Th-2 local equilibrium was significantly reduced (0.29 versus 0.10, p = .004), through very significant increase of TWEAK expression, in patients who were subsequently pregnant under prednisone. Prednisone 230-240 interleukin 18 Homo sapiens 4-9 29780394-7 2018 Results showed that uric acid serum concentration was significantly increased in PPMS; in these and in AMS patients, mRNA for NLRP3, ASC, and IL-18 was upregulated as well, but caspase-8 mRNA was upregulated only in PPMS. Uric Acid 20-29 interleukin 18 Homo sapiens 142-147 29854715-5 2018 Significant correlations between IL-18 and ALT, GGT, triglycerides, hsCRP, and the degree of liver steatosis were demonstrated. Triglycerides 53-66 interleukin 18 Homo sapiens 33-38 29970735-0 2018 Evaluation of interleukin-18 in children with steroid-sensitive nephrotic syndrome before and after using levamisole. Steroids 46-53 interleukin 18 Homo sapiens 14-28 29970735-4 2018 The aim of the study was to investigate the IL-18 levels in serum from children with SSNS during relapse and remission after using levamisole or three months in a trial to test the efficacy of its action in reducing frequency of relapses in SSNS. Levamisole 131-141 interleukin 18 Homo sapiens 44-49 29970735-7 2018 We found that IL-18 level showed a significant elevation after three months of levamisole therapy compared to its level before initiation of levamisole therapy, with no relapses in these three months, no reported side effect, and significant reduction of cumulative dose of steroids. Levamisole 79-89 interleukin 18 Homo sapiens 14-19 29970735-7 2018 We found that IL-18 level showed a significant elevation after three months of levamisole therapy compared to its level before initiation of levamisole therapy, with no relapses in these three months, no reported side effect, and significant reduction of cumulative dose of steroids. Levamisole 141-151 interleukin 18 Homo sapiens 14-19 29970735-7 2018 We found that IL-18 level showed a significant elevation after three months of levamisole therapy compared to its level before initiation of levamisole therapy, with no relapses in these three months, no reported side effect, and significant reduction of cumulative dose of steroids. Steroids 274-282 interleukin 18 Homo sapiens 14-19 29970735-8 2018 Levamisole effectiveness in reduction of relapses of SSNS may be due to resetting of the type 1/type 2 imbalance, proved by induction of IL 18 may be useful in the therapy. Levamisole 0-10 interleukin 18 Homo sapiens 137-142 29676014-5 2018 In addition, the successful use of macrolide antibiotics to treat lung infections in these conditions further confirms that the innate immune system is the key conductor of inflammation in these pulmonary diseases, as there is a strong body of evidence that macrolides are able to modulate the NLRP3 inflammasome and interleukin-1beta and interleukin-18 secretion, both of which are central players in the innate immune response. Macrolides 35-44 interleukin 18 Homo sapiens 339-353 29731751-8 2018 Together with IL-3, IL-18 stimulates mast cells and basophils to produce IL-4, IL-13, and chemical mediators such as histamine. Histamine 117-126 interleukin 18 Homo sapiens 20-25 29676014-5 2018 In addition, the successful use of macrolide antibiotics to treat lung infections in these conditions further confirms that the innate immune system is the key conductor of inflammation in these pulmonary diseases, as there is a strong body of evidence that macrolides are able to modulate the NLRP3 inflammasome and interleukin-1beta and interleukin-18 secretion, both of which are central players in the innate immune response. Macrolides 258-268 interleukin 18 Homo sapiens 339-353 29453279-5 2018 Finally, the ability of IL-12+IL-18 to activate an innate antimicrobial response in human primary macrophages was dependent on the autonomous production of IFN-gamma and the CAMP/autophagy pathway. Cyclic AMP 174-178 interleukin 18 Homo sapiens 30-35 29675024-5 2018 Then, we found that peripheral blood mononuclear cells (PBMCs) from IPF patients released IL-1alpha and IL-18 in a NLRP3- and calpain-independent manner after LPS +- ATP stimulation. Adenosine Triphosphate 166-169 interleukin 18 Homo sapiens 104-109 29550474-9 2018 IL-18 secretion was inhibited by PGE2 treatment, and PGE2 inhibited inflammasome complex (ASC/Cas-1/NLRP3) formation in THP-1 cells. Dinoprostone 33-37 interleukin 18 Homo sapiens 0-5 29432801-8 2018 The inhibition assay showed that glybenclamide (a K+ efflux inhibitor that blocks NLRP3 inflammasome activation) and N-benzyloxycarbony-Val-Ala-Asp (O-methyl)-fluoromethylketone (Z-VAD-FMK; a caspase-1 inhibitor) and NLRP3 depletion with siRNAs reduced the levels of IL-1beta and IL-18 release. n-benzyloxycarbony 117-135 interleukin 18 Homo sapiens 280-285 29432801-0 2018 Leptospira interrogans infection leads to IL-1beta and IL-18 secretion from a human macrophage cell line through reactive oxygen species and cathepsin B mediated-NLRP3 inflammasome activation. Reactive Oxygen Species 113-136 interleukin 18 Homo sapiens 55-60 29432801-8 2018 The inhibition assay showed that glybenclamide (a K+ efflux inhibitor that blocks NLRP3 inflammasome activation) and N-benzyloxycarbony-Val-Ala-Asp (O-methyl)-fluoromethylketone (Z-VAD-FMK; a caspase-1 inhibitor) and NLRP3 depletion with siRNAs reduced the levels of IL-1beta and IL-18 release. Alanine 140-143 interleukin 18 Homo sapiens 280-285 29432801-8 2018 The inhibition assay showed that glybenclamide (a K+ efflux inhibitor that blocks NLRP3 inflammasome activation) and N-benzyloxycarbony-Val-Ala-Asp (O-methyl)-fluoromethylketone (Z-VAD-FMK; a caspase-1 inhibitor) and NLRP3 depletion with siRNAs reduced the levels of IL-1beta and IL-18 release. Glyburide 33-46 interleukin 18 Homo sapiens 280-285 29432801-8 2018 The inhibition assay showed that glybenclamide (a K+ efflux inhibitor that blocks NLRP3 inflammasome activation) and N-benzyloxycarbony-Val-Ala-Asp (O-methyl)-fluoromethylketone (Z-VAD-FMK; a caspase-1 inhibitor) and NLRP3 depletion with siRNAs reduced the levels of IL-1beta and IL-18 release. fluoromethylketone 159-177 interleukin 18 Homo sapiens 280-285 29432801-9 2018 Moreover, the levels of IL-1beta and IL-18 production decreased in CA-074 (a cathepsin B inhibitor) and NAC (an anti-oxidant) pretreated human macrophages, compared to untreated controls. N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline 67-73 interleukin 18 Homo sapiens 37-42 29432801-10 2018 This study suggests that L. interrogans infection leads to reactive oxygen species (ROS)- and cathepsin B-dependent NLRP3 inflammasome activation, which subsequently mediates caspase-1 activation and IL-1beta and IL-18 release. Reactive Oxygen Species 59-82 interleukin 18 Homo sapiens 213-218 29432801-10 2018 This study suggests that L. interrogans infection leads to reactive oxygen species (ROS)- and cathepsin B-dependent NLRP3 inflammasome activation, which subsequently mediates caspase-1 activation and IL-1beta and IL-18 release. Reactive Oxygen Species 84-87 interleukin 18 Homo sapiens 213-218 29743866-5 2018 Data from ELISA and Western blot assays showed that Dex abrogated the promoting effects of LPS/ATP on the release of pro-inflammatory cytokines including IL-1beta and IL-18 in the cell medium and the expression of NLRP3 and its downstream target caspase-1 in HMC3 cells. Dexmedetomidine 52-55 interleukin 18 Homo sapiens 167-172 29743866-5 2018 Data from ELISA and Western blot assays showed that Dex abrogated the promoting effects of LPS/ATP on the release of pro-inflammatory cytokines including IL-1beta and IL-18 in the cell medium and the expression of NLRP3 and its downstream target caspase-1 in HMC3 cells. Adenosine Triphosphate 95-98 interleukin 18 Homo sapiens 167-172 29218606-6 2018 Then we found that PI3K inhibitor LY294002 reduced L-selectin- and PSGL-1-induced mRNA upregulation of IL-18 in Jurkat cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 34-42 interleukin 18 Homo sapiens 103-108 29269076-7 2018 The results showed that these GME exosomes, carrying IL-15, IL-18 and 4-1BBL proteins similar to their host cells, could activate NK cells, increase the cytotoxicity of NK cells on some tumour cells in a short treatment (4h) and promote NK cells proliferation. gme 30-33 interleukin 18 Homo sapiens 60-65 29264744-8 2018 Our data demonstrated that deficiency of IL-18 promoted the progression and development of 4NQO-induced ESCC. 4-Nitroquinoline-1-oxide 91-95 interleukin 18 Homo sapiens 41-46 29743792-14 2018 Further wider-scale studies are needed to evaluate the actual role of IL18 polymorphisms in treatment response with sofosbuvir/daclatasvir. Sofosbuvir 116-126 interleukin 18 Homo sapiens 70-74 29743792-14 2018 Further wider-scale studies are needed to evaluate the actual role of IL18 polymorphisms in treatment response with sofosbuvir/daclatasvir. daclatasvir 127-138 interleukin 18 Homo sapiens 70-74 29024030-8 2018 Meanwhile, melatonin also attenuated the expression of pyroptosis-related genes, including NLRP3, ASC, cleaved caspase1, NF-kappaB/GSDMD, GSDMD N-termini, IL-1beta, and IL-18 in aortic endothelium of melatonin-treated animals. Melatonin 11-20 interleukin 18 Homo sapiens 169-174 29416034-7 2018 Moreover, silencing NLRP3 or ASC by small interfering RNA efficiently suppressed nicotine-induced caspase-1 cleavage, IL-18 and IL-1beta production, and pyroptosis in HAECs. Nicotine 81-89 interleukin 18 Homo sapiens 118-123 29479354-7 2018 To further understand the differential expression of cytokines/chemokines, we showed that WFA alters the nigericin-induced co-localization of NLRP3 and ASC proteins, thereby inhibiting caspase-1 activation, which is responsible for the cleavage and maturation of pro-inflammatory cytokines IL-1beta and IL-18. Nigericin 105-114 interleukin 18 Homo sapiens 303-308 29531586-3 2018 AIM: To investigate the effect of the histone deacetylases inhibitor Suberoylanilide Hydroxamic Acid (SAHA) on the gene expression and secretion of both cytokines, IL-18 and TNF-alpha, according to their contribution to the cancer development and anticancer immunity. Vorinostat 69-100 interleukin 18 Homo sapiens 164-169 29531586-3 2018 AIM: To investigate the effect of the histone deacetylases inhibitor Suberoylanilide Hydroxamic Acid (SAHA) on the gene expression and secretion of both cytokines, IL-18 and TNF-alpha, according to their contribution to the cancer development and anticancer immunity. Vorinostat 102-106 interleukin 18 Homo sapiens 164-169 29472923-0 2018 A Prominent Role of Interleukin-18 in Acetaminophen-Induced Liver Injury Advocates Its Blockage for Therapy of Hepatic Necroinflammation. Acetaminophen 38-51 interleukin 18 Homo sapiens 20-34 29472923-9 2018 As IL-18 serum levels increase in patients after APAP overdosing, targeting IL-18 may evolve as novel therapeutic option in those hard-to-treat patients where standard therapy with N-acetylcysteine is unsuccessful. Acetylcysteine 181-197 interleukin 18 Homo sapiens 76-81 29416034-6 2018 Treatment of human aortic endothelial cells (HAECs) with nicotine resulted in NLRP3-ASC inflammasome activation and pyroptosis, as evidenced by cleavage of caspase-1, production of downstream interleukin (IL)-1beta and IL-18, and elevation of LDH activity and increase of propidium iodide (PI) positive cells, which were all inhibited by caspase-1 inhibitor. Nicotine 57-65 interleukin 18 Homo sapiens 219-224 29352570-3 2018 It is now also known that cholesterol crystals are present through all stages of atherosclerosis and can activate the NLRP3 inflammasome within these inflammatory cells to produce interleukin 1beta and interleukin 18 - key mediators in the inflammatory cascade that drive plaque progression and instability. Cholesterol 26-37 interleukin 18 Homo sapiens 202-216 29467654-6 2018 ATP acting via P2X7 receptor is the second signal to the inflammasome activation, inducing both maturation and release of pro-inflammatory cytokines, such as IL-1beta and IL-18, and the production of reactive nitrogen and oxygen species. Adenosine Triphosphate 0-3 interleukin 18 Homo sapiens 171-176 29342149-11 2018 Low levels of muscle IL-18 mRNA correlated to high levels of ceramides (r = -0.31, p = 0.038) and sphingosine-1P (r = -0.29, p = 0.046) in skeletal muscle, whereas such a correlation was not found in healthy controls. Ceramides 61-70 interleukin 18 Homo sapiens 21-26 29260441-11 2018 IL-6 and IL-18 expression in the striatum was significantly higher in the HIV-1Tg EtOH group than in the F344 EtOH group. Ethanol 82-86 interleukin 18 Homo sapiens 9-14 29260441-11 2018 IL-6 and IL-18 expression in the striatum was significantly higher in the HIV-1Tg EtOH group than in the F344 EtOH group. Ethanol 110-114 interleukin 18 Homo sapiens 9-14 29260441-12 2018 DHA significantly decreased the high levels of IL-6, IL-18, and NF-kappaB expression observed in the HIV-1Tg EtOH group. Docosahexaenoic Acids 0-3 interleukin 18 Homo sapiens 53-58 29342149-11 2018 Low levels of muscle IL-18 mRNA correlated to high levels of ceramides (r = -0.31, p = 0.038) and sphingosine-1P (r = -0.29, p = 0.046) in skeletal muscle, whereas such a correlation was not found in healthy controls. sphingosine-1p 98-112 interleukin 18 Homo sapiens 21-26 29342149-12 2018 Low expression of IL-18 mRNA in skeletal muscle correlated to elevated concentration of circulating triglycerides (Rp = -0.73, p<0.0001). Triglycerides 100-113 interleukin 18 Homo sapiens 18-23 29149250-7 2017 The DNA methylation levels of cg03636183 in F2RL3 were associated with interleukin-18 concentration (-0.11 pg/mL, 95% CI: -0.19, -0.04). cg03636183 30-40 interleukin 18 Homo sapiens 71-85 29258746-6 2018 Meanwhile, silica persistently activated NLRP3 inflammasome as indicated by continuously elevated extracellular levels of interleukin-1beta (IL-1beta) and IL-18. Silicon Dioxide 11-17 interleukin 18 Homo sapiens 155-160 29079364-0 2018 Assessment of metal sensitizer potency with the reconstructed human epidermis IL-18 assay. Metals 14-19 interleukin 18 Homo sapiens 78-83 29079364-6 2018 Metal salts were labelled (YES/NO) as sensitizer if a threshold of more than 5 fold IL18 release was reached. metal salts 0-11 interleukin 18 Homo sapiens 84-88 29956204-11 2018 In both experimental and human NASH, livers contain cholesterol crystals which are a second signal for NLRP3 activation; this causes interleukin (IL)-1beta and IL18 secretion to attract and activate macrophages and neutrophils. Cholesterol 52-63 interleukin 18 Homo sapiens 160-164 28549109-6 2018 Further investigation revealed that the rapid inflammasome-dependent activation of IL-18, but not IL-1beta, was the critical up-stream regulator for elevated chemokine expression in the myocardium upon ISO induced beta1-AR-ROS signalling. ros 223-226 interleukin 18 Homo sapiens 83-88 28549109-7 2018 Indeed, a positive correlation was observed between the serum levels of norepinephrine and IL-18 in patients with chest pain. Norepinephrine 72-86 interleukin 18 Homo sapiens 91-96 29163679-10 2017 The DEGs of MYC, HSPA5, IL18 and CXCR4 may exert important roles in molecular mechanisms of PC cells with glutamine. Glutamine 106-115 interleukin 18 Homo sapiens 24-28 30138921-9 2018 RESULTS: Here, we clarified that ethanol treatment could cause cell DNA damage, activate caspase-1, and promote the generation and release of IL-1beta and IL-18. Ethanol 33-40 interleukin 18 Homo sapiens 155-160 29854992-12 2018 RESULTS: Cultures of PBMCs and THP1 cells exposed to HEMA in vitro produced more IL-1ss and IL-18 than did control cells. hydroxyethyl methacrylate 53-57 interleukin 18 Homo sapiens 92-97 30123891-6 2018 Excessive ROS can then result in activation of the NLRP3 inflammasome and secretion of IL-1 and IL-18 by caspase-1. Reactive Oxygen Species 10-13 interleukin 18 Homo sapiens 96-101 30326484-3 2018 The proinflammatory cytokine IL-18, with a recognized role in brain functions, may influence serotonin metabolism and appears to be associated with alexithymia. Serotonin 93-102 interleukin 18 Homo sapiens 29-34 29262323-3 2017 ATP then acts via a feedback mechanism on the P2X7 channel to activate the NLRP3 inflammasome and subsequently process and release interleukin (IL)-18. Adenosine Triphosphate 0-3 interleukin 18 Homo sapiens 131-150 29258239-1 2017 Saturated fatty acids were proposed to activate the NLRP3 inflammasome, a molecular platform that mediates the processing of interleukin (IL)-1beta and IL-18. Fatty Acids 0-21 interleukin 18 Homo sapiens 152-157 29230430-10 2018 Conclusions: TEGDMA affects production of proinflammatory cytokines IL-1beta, IL-6, IL-8, IL-18 and TNF-alpha. triethylene glycol dimethacrylate 13-19 interleukin 18 Homo sapiens 90-95 28860220-11 2017 In VSMCs, IL-18 significantly decreased expression of contractile markers alpha-smooth muscle actin, smooth muscle 22 alpha, and increased calcium deposition, alkaline phosphatase activity, and expression of osteogenic differentiation markers bone morphogenetic protein-2, Runx2 (runt-related transcription factor 2), and osteocalcin (P<0.05). Calcium 139-146 interleukin 18 Homo sapiens 10-15 28990778-8 2017 Compared with the BaP group, the autophagy inhibitor 3-MA significantly (p < 0.01) inhibited the release of LDH by 70.53% +- 0.46 and NO by 50.36% +- 0.80, the increase of electrical conductivity by 12.08% +- 0.55, and the expressions of pyroptotic marker proteins (Caspase-1, Cox-2, IL-1beta, IL-18). 3-methyladenine 53-57 interleukin 18 Homo sapiens 297-302 28684545-6 2017 Plasma IL-18 levels were determined from patients who were diagnosed with bronchiectasis isolated with or without P. aeruginosa and treated with azithromycin for 3-5 days. Azithromycin 145-157 interleukin 18 Homo sapiens 7-12 28684545-7 2017 Azithromycin treatment enhanced bacterial clearance and attenuated lung injury in mice chronically infected with P. aeruginosa, which resulted from the inhibition of caspase-1-dependent IL-1beta and IL-18 secretion. Azithromycin 0-12 interleukin 18 Homo sapiens 199-204 28684545-10 2017 Azithromycin administration markedly decreased IL-18 secretion in bronchiectasis patients. Azithromycin 0-12 interleukin 18 Homo sapiens 47-52 29096724-9 2017 RESULTS: Treating HepG2 cells with PA-LPS caused NLRP3 inflammation activation, including overexpression of NLRP3 and caspase-1, and overproduction of IL-1beta and IL-18 as well as TNF-alpha from HepG2 cells. pa-lps 35-41 interleukin 18 Homo sapiens 164-169 28860220-13 2017 Inhibition of TRPM7 channel by 2-aminoethoxy-diphenylborate or TRPM7 small interfering RNA prevented IL-18-enhanced osteogenic differentiation and VSMCs calcification. 2-aminoethoxydiphenyl borate 31-59 interleukin 18 Homo sapiens 101-106 28860220-15 2017 IL-18 enhances VSMCs osteogenic differentiation and subsequent VC induced by beta-glycerophosphate via TRPM7 channel activation. beta-glycerophosphoric acid 77-98 interleukin 18 Homo sapiens 0-5 28266737-6 2017 We transfected polyinosinic:polycytidylic acid (poly I:C), a synthetic viral dsRNA analogue, into cultured primary human keratinocytes at the aid of Lipofectamine 2000, and found that transfected poly I:C activated caspase-1 and induced caspase-1-dependent release of IL-1beta and IL-18, which were suppressed on transfection with NLRP3 siRNA. polyinosinic: 15-28 interleukin 18 Homo sapiens 281-286 28266737-6 2017 We transfected polyinosinic:polycytidylic acid (poly I:C), a synthetic viral dsRNA analogue, into cultured primary human keratinocytes at the aid of Lipofectamine 2000, and found that transfected poly I:C activated caspase-1 and induced caspase-1-dependent release of IL-1beta and IL-18, which were suppressed on transfection with NLRP3 siRNA. Poly I-C 48-56 interleukin 18 Homo sapiens 281-286 28266737-6 2017 We transfected polyinosinic:polycytidylic acid (poly I:C), a synthetic viral dsRNA analogue, into cultured primary human keratinocytes at the aid of Lipofectamine 2000, and found that transfected poly I:C activated caspase-1 and induced caspase-1-dependent release of IL-1beta and IL-18, which were suppressed on transfection with NLRP3 siRNA. Poly I-C 196-204 interleukin 18 Homo sapiens 281-286 28652186-6 2017 With respect to the IL-18 gene polymorphisms, at -137 G>C variant, GG genotype was positively associated in PTB while at -607 C>A variant positive association was shown with AC genotype in TBDM, their HHC and DM; GACC diplotype in TBDM and GCGC in PTB. tbdm 195-199 interleukin 18 Homo sapiens 20-25 29552067-0 2017 Effect of Hypertonic Saline 5% on Early Graft Function and Urinary Interleukin 18 and Neutrophil Gelatinase-Associated Lipocalin in Deceased-Donor Kidney Transplantation. Sodium Chloride 21-27 interleukin 18 Homo sapiens 67-81 28870124-7 2017 Similarly, the expression of NLRP3 and caspase-1 p10 and the release of IL-1beta and IL-18 were significantly increased after ZnO-NPs treatment, which indicated that the NLRP3 inflammasome was activated by ZnO-NPs. Zinc Oxide 126-129 interleukin 18 Homo sapiens 85-90 28870124-10 2017 Furthermore, the ability of ZnO-NPs to increase the production of IL-1beta and IL-18 was significantly inhibited by GEL. Zinc Oxide 28-31 interleukin 18 Homo sapiens 79-84 28652186-6 2017 With respect to the IL-18 gene polymorphisms, at -137 G>C variant, GG genotype was positively associated in PTB while at -607 C>A variant positive association was shown with AC genotype in TBDM, their HHC and DM; GACC diplotype in TBDM and GCGC in PTB. gcgc 246-250 interleukin 18 Homo sapiens 20-25 28713995-8 2017 The hub genes of JUN, FOS, MYC and ACTA2, as well as the DEGs IL18 and CD274 that were associated with the immune response in GO terms may exert important functions in the molecular mechanisms of PABC. 4-azidobenzylcarazolol 196-200 interleukin 18 Homo sapiens 62-66 28429571-0 2017 Melatonin antagonizes interleukin-18-mediated inhibition on neural stem cell proliferation and differentiation. Melatonin 0-9 interleukin 18 Homo sapiens 22-36 28429571-4 2017 In this study, we tested whether melatonin, a potent antioxidant, could promote the NSC proliferation and neuronal differentiation, especially, in the presence of the pro-inflammatory cytokine interleukin-18 (IL-18). Melatonin 33-42 interleukin 18 Homo sapiens 193-207 28429571-4 2017 In this study, we tested whether melatonin, a potent antioxidant, could promote the NSC proliferation and neuronal differentiation, especially, in the presence of the pro-inflammatory cytokine interleukin-18 (IL-18). Melatonin 33-42 interleukin 18 Homo sapiens 209-214 28429571-6 2017 All inhibitory effects of IL-18 on NSCs were significantly reduced by melatonin treatment. Melatonin 70-79 interleukin 18 Homo sapiens 26-31 28429571-7 2017 Moreover, melatonin application increased the production of both brain-derived and glial cell-derived neurotrophic factors (BDNF, GDNF) in IL-18-stimulated NSCs. Melatonin 10-19 interleukin 18 Homo sapiens 139-144 28429571-9 2017 A potentially protective mechanism of melatonin on the inhibition of NSC"s differentiation caused IL-18 may attribute to the up-regulation of these two major neurotrophic factors, BNDF and GNDF. Melatonin 38-47 interleukin 18 Homo sapiens 98-103 28547650-8 2017 Leu-Leu-OMe increased the expression of NLRP3, IL-1beta, and IL-18 in HUVECs. leucyl-leucine-methyl ester 0-11 interleukin 18 Homo sapiens 61-66 28858634-4 2017 Moreover, semen interleukin (IL)-17 and IL-18 levels in DM males were significantly higher than those in normal males (p<0.05) and were positively correlated with blood glucose level and sperm DNA fragmentation index. Glucose 172-179 interleukin 18 Homo sapiens 40-45 28858634-5 2017 DM increased blood glucose levels, consequently inducing the abnormal expression of IL-17 and IL-18. Glucose 19-26 interleukin 18 Homo sapiens 94-99 28878677-5 2017 In addition, we found that decreased NLRP3 expression by Teuvincenone F suppressed NLRP3 inflammasome activation and IL-1beta/IL-18 maturation. teuvincenone 57-69 interleukin 18 Homo sapiens 126-131 28711708-7 2017 Ezetimibe and simvastatin combination treatment lowered fasting total cholesterol, LDLc and Lp(a) concentrations and Apo B/A1 ratio and suppressed the MNC expression of IL-1beta and CD68 (by 21 +- 7 and 24 +- 10, p < 0.05) and the concentrations of LPS, CRP, FFA and IL-18 by 24 +- 7%, 32 +- 11%, 19 +- 8% 15 +- 4%, respectively, (p < 0.05). Ezetimibe 0-9 interleukin 18 Homo sapiens 270-275 28798075-10 2017 Furthermore, new inhibitors of IL-18 (GSK 1070806, ABT-325, rIL-18BP (IL-18 binding protein)) and IL-33 (CNTO-7160) are presently under clinical studies and other molecules are being developed to target IL-1 family cytokines. gsk 38-41 interleukin 18 Homo sapiens 31-36 28798075-10 2017 Furthermore, new inhibitors of IL-18 (GSK 1070806, ABT-325, rIL-18BP (IL-18 binding protein)) and IL-33 (CNTO-7160) are presently under clinical studies and other molecules are being developed to target IL-1 family cytokines. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid 51-54 interleukin 18 Homo sapiens 31-36 28711708-7 2017 Ezetimibe and simvastatin combination treatment lowered fasting total cholesterol, LDLc and Lp(a) concentrations and Apo B/A1 ratio and suppressed the MNC expression of IL-1beta and CD68 (by 21 +- 7 and 24 +- 10, p < 0.05) and the concentrations of LPS, CRP, FFA and IL-18 by 24 +- 7%, 32 +- 11%, 19 +- 8% 15 +- 4%, respectively, (p < 0.05). Simvastatin 14-25 interleukin 18 Homo sapiens 270-275 28605710-5 2017 DEX (5muMu) exposure for 3d significantly increased the expression of NLRP-1, ASC, caspase-1 and IL-1beta in the hippocampal neurons and the release of IL-1beta and IL-18 in the supernatants. 5mumu 5-10 interleukin 18 Homo sapiens 165-170 28605710-5 2017 DEX (5muMu) exposure for 3d significantly increased the expression of NLRP-1, ASC, caspase-1 and IL-1beta in the hippocampal neurons and the release of IL-1beta and IL-18 in the supernatants. Dextromethorphan 0-3 interleukin 18 Homo sapiens 165-170 29744188-5 2017 We hypothesize that H2S affects the inflammatory host response by inducing formation of the NLRP3 inflammasome and thereby causes the secretion of IL-1ss and IL-18. Hydrogen Sulfide 20-23 interleukin 18 Homo sapiens 158-163 28342224-4 2017 Interleukin-18 was higher after aminobisphosphonate stimulation due to activation of the inflammasome pathway. aminobisphosphonate 32-51 interleukin 18 Homo sapiens 0-14 28342224-7 2017 When Vgamma9Vdelta2 T cells from HIV-positive individuals were stimulated with isopentenyl pyrophosphate in the presence of IL-18, there was increased proliferation, accumulation of memory cells, and higher expression of CD56, NKG2D and CD107a (markers of cytotoxic effector phenotype). isopentenyl pyrophosphate 79-104 interleukin 18 Homo sapiens 124-129 29744188-8 2017 PBMCs exposed to NaHS produced more IL-1ss and IL-18 than unexposed control cells (p = .023 and p = .008, respectively). sodium bisulfide 17-21 interleukin 18 Homo sapiens 47-52 29744188-0 2017 Hydrogen sulfide exposure induces NLRP3 inflammasome-dependent IL-1beta and IL-18 secretion in human mononuclear leukocytes in vitro. Hydrogen Sulfide 0-16 interleukin 18 Homo sapiens 76-81 29744188-1 2017 The aim was to investigate if hydrogen sulfide (H2S) induces the formation of the NLRP3 inflammasome and subsequent IL-1beta and IL-18 secretion in human peripheral blood mononuclear cells (PBMCs) and in the human monocyte cell line THP1. Hydrogen Sulfide 30-46 interleukin 18 Homo sapiens 129-134 29744188-9 2017 An increase of extracellular potassium ions (K+) inhibited the secretion of IL-1ss and IL-18 (p = .008). Potassium 29-38 interleukin 18 Homo sapiens 87-92 29744188-1 2017 The aim was to investigate if hydrogen sulfide (H2S) induces the formation of the NLRP3 inflammasome and subsequent IL-1beta and IL-18 secretion in human peripheral blood mononuclear cells (PBMCs) and in the human monocyte cell line THP1. Hydrogen Sulfide 48-51 interleukin 18 Homo sapiens 129-134 29744188-10 2017 Further, NaHS triggered the secretion of IL-1ss and IL-18 in human THP1-Null monocytes (p = .0006 and p = .002, respectively), while the NaHS-dependent secretion was reduced in the monocyte cell lines unable to form the NLRP3 inflammasome. sodium bisulfide 9-13 interleukin 18 Homo sapiens 52-57 29744188-11 2017 Hence, the results suggest that NaHS induces the formation of the NLRP3 inflammasome and thus the secretion of IL-1ss and IL-18. sodium bisulfide 32-36 interleukin 18 Homo sapiens 122-127 29744188-12 2017 Enhanced NLRP3 inflammasome-dependent secretion of IL-1beta and IL-18 in human mononuclear leukocytes exposed to NaHS in vitro is reported. sodium bisulfide 113-117 interleukin 18 Homo sapiens 64-69 26848183-8 2017 In vitro, TiO2 particles were taken up by IECs and macrophages and triggered NLRP3-ASC-caspase-1 assembly, caspase-1 cleavage and the release of NLRP3-associated interleukin (IL)-1beta and IL-18. titanium dioxide 10-14 interleukin 18 Homo sapiens 189-194 28322925-6 2017 Inhibition of STAT3 phosphorylation by S3I-201 abrogated the antiviral ability of mpIL-22 and the mpIL-22-induced expression of BD-2, IL-18, and IFN-lambda. mpil 98-102 interleukin 18 Homo sapiens 134-139 28489580-3 2017 Here we demonstrate that autophagy induction by rapamycin suppressed the production of IL-1beta and IL-18 in lipopolysaccharide- and adenosine triphosphate-activated macrophages at the post-transcriptional level by eliminating mitochondrial ROS (mtROS) and pro-IL1beta in a p62/SQSTM1-dependent manner. Adenosine Triphosphate 133-155 interleukin 18 Homo sapiens 100-105 28489580-3 2017 Here we demonstrate that autophagy induction by rapamycin suppressed the production of IL-1beta and IL-18 in lipopolysaccharide- and adenosine triphosphate-activated macrophages at the post-transcriptional level by eliminating mitochondrial ROS (mtROS) and pro-IL1beta in a p62/SQSTM1-dependent manner. ros 241-244 interleukin 18 Homo sapiens 100-105 28430754-14 2017 On PICU day 1, interleukin-18 predicted acute kidney injuryserum creatinine with area under the curve=0.82, but neutrophil gelatinase-associated lipocalin and liver fatty acid binding protein predicted acute kidney injuryserum creatinine with area under the curve of less than or equal to 0.69; on PICU day 2, area under the curve was higher (not shown). Creatinine 65-75 interleukin 18 Homo sapiens 15-29 28326454-7 2017 Increased production of ROS and expression of IL-1beta, IL-18, and caspase-1 genes and proteins were observed in U937 and THP-1 cells incubated with fructose and were effectively inhibited by quercetin and ascorbic acid. Fructose 149-157 interleukin 18 Homo sapiens 56-61 28326454-7 2017 Increased production of ROS and expression of IL-1beta, IL-18, and caspase-1 genes and proteins were observed in U937 and THP-1 cells incubated with fructose and were effectively inhibited by quercetin and ascorbic acid. Quercetin 192-201 interleukin 18 Homo sapiens 56-61 28430754-15 2017 Interleukin-18 and liver fatty acid binding protein on day 1 acute kidney injury predicted prolonged acute kidney injuryserum creatinine (area under the curve=0.74 and 0.83, respectively). Creatinine 126-136 interleukin 18 Homo sapiens 0-14 28611778-4 2017 In a subgroup of patients, the addition of peg-IFNlambda provoked high serum levels of antiviral cytokine IL-18. Polyethylene Glycols 43-46 interleukin 18 Homo sapiens 106-111 28611778-4 2017 In a subgroup of patients, the addition of peg-IFNlambda provoked high serum levels of antiviral cytokine IL-18. ifnlambda 47-56 interleukin 18 Homo sapiens 106-111 28428272-6 2017 MS-444 treatment also abrogated tumor cell apoptosis and depleted tumor-associated eosinophils, accompanied by a decrease in IL18 and eotaxin-1. 5,8-dihydroxy-3-methyl-4-(9H)-naphtho(2,3-c)furanone 0-6 interleukin 18 Homo sapiens 125-129 26874912-6 2017 RESULTS: Anti-inflammatory cytokines (interleukin-6 and interleukin-18) were increased in the fasting state and/or decreased in some women during the oral glucose tolerance test, as opposed to inflammatory mediators such as macrophage migration inhibitory factor and matrix metallopeptidase-9 that increased during the oral glucose tolerance test especially in subjects with weight excess. Glucose 155-162 interleukin 18 Homo sapiens 56-70 28013367-6 2017 Using human mesothelial cells, we first demonstrate that asbestos and carbon nanotubes induced caspase-1 activation and high-mobility group box 1, interleukin 1 beta and interleukin 18 secretion was blocked by Cytochalasin D (Cyto D) an actin polymerization inhibitor. Asbestos 57-65 interleukin 18 Homo sapiens 170-184 28013367-6 2017 Using human mesothelial cells, we first demonstrate that asbestos and carbon nanotubes induced caspase-1 activation and high-mobility group box 1, interleukin 1 beta and interleukin 18 secretion was blocked by Cytochalasin D (Cyto D) an actin polymerization inhibitor. Carbon 70-76 interleukin 18 Homo sapiens 170-184 28013367-6 2017 Using human mesothelial cells, we first demonstrate that asbestos and carbon nanotubes induced caspase-1 activation and high-mobility group box 1, interleukin 1 beta and interleukin 18 secretion was blocked by Cytochalasin D (Cyto D) an actin polymerization inhibitor. Cytochalasins 210-222 interleukin 18 Homo sapiens 170-184 28367997-3 2017 When added to cell cultures, PFDA significantly stimulated IL-1beta and IL18 secretion and their mRNA levels compared with control cells. perfluorodecanoic acid 29-33 interleukin 18 Homo sapiens 72-76 27585668-9 2017 Allergens were able to induce both genes, however, with different kinetic, with DNCB more rapidly upregulating Blimp-1 and inducing IL-18 production, compared to PPD. Dinitrochlorobenzene 80-84 interleukin 18 Homo sapiens 132-137 28671097-1 2017 The effect of citrate to Desloratadine Citrate Disodium set in the treatment of chronic urticaria in patients with IL4, IL18, and IL23, IL33 levels was investigated. Citric Acid 14-21 interleukin 18 Homo sapiens 120-124 28222674-3 2017 This multi-center, randomized, double-blinded, placebo-controlled study aimed to investigate whether 6% HES 130/0.4 administration caused postoperative AKI, which can be revealed by urinary and plasma NGAL and IL-18 estimations in elderly patients with normal renal function undergoing hip arthroplasty under spinal anesthesia. Hydroxyethyl Starch Derivatives 104-107 interleukin 18 Homo sapiens 210-215 28277142-0 2017 Effects of human chorionic gonadotropin, estradiol, and progesterone on interleukin-18 expression in human decidual tissues. Estradiol 41-50 interleukin 18 Homo sapiens 72-86 28277142-0 2017 Effects of human chorionic gonadotropin, estradiol, and progesterone on interleukin-18 expression in human decidual tissues. Progesterone 56-68 interleukin 18 Homo sapiens 72-86 28277142-3 2017 This study was designed to assess the effects of estradiol, human chorionic gonadotropin (hCG), and progesterone on IL-18 expression in human decidual tissues. Estradiol 49-58 interleukin 18 Homo sapiens 116-121 28277142-5 2017 We found that Estradiol, hCG, and progesterone inhibited decidual cell growth independent of dosage and time.IL-18 secretion in the spontaneous abortion group was increased in the decidual cells over time, but all hormones significantly reduced its secretion (p < 0.05). Estradiol 14-23 interleukin 18 Homo sapiens 109-114 28277142-6 2017 Our results indicate that estradiol, hCG, and progesterone can reduce IL-18 secretion in the cultured endometrial stromal cells from patients who experienced spontaneous abortion to the levels observed following normal pregnancy. Estradiol 26-35 interleukin 18 Homo sapiens 70-75 28277142-6 2017 Our results indicate that estradiol, hCG, and progesterone can reduce IL-18 secretion in the cultured endometrial stromal cells from patients who experienced spontaneous abortion to the levels observed following normal pregnancy. Progesterone 46-58 interleukin 18 Homo sapiens 70-75 28277142-7 2017 Progesterone can significantly reduce IL-18 expression and increase growth of CD56+ CD16- uNK cells, suggesting that these activities may underlie the mechanism by which progesterone improves pregnancy outcomes. Progesterone 170-182 interleukin 18 Homo sapiens 38-43 28056339-3 2017 We recently found that asbestos activates the nod-like receptor family member containing a pyrin domain 3 (NLRP3) inflammasome in a protracted manner, leading to an up-regulation of IL-1beta and IL-18 production in human mesothelial cells. Asbestos 23-31 interleukin 18 Homo sapiens 195-200 28057714-7 2017 Furthermore, the patients with pSS showed high serum levels of total IL-18, free IL-18 and IL-18BP compared with the HCs. pss 31-34 interleukin 18 Homo sapiens 69-74 28057714-7 2017 Furthermore, the patients with pSS showed high serum levels of total IL-18, free IL-18 and IL-18BP compared with the HCs. pss 31-34 interleukin 18 Homo sapiens 81-86 28057714-9 2017 The serum levels of IL-37, which were correlated with antibody production and the serum levels of total IL-18 and IL-18BP, were elevated in the patients with pSS. pss 158-161 interleukin 18 Homo sapiens 104-109 28087305-0 2017 Circulating interleukin-18 (IL-18) is a predictor of response to gemcitabine based chemotherapy in patients with pancreatic adenocarcinoma. gemcitabine 65-76 interleukin 18 Homo sapiens 12-26 28087305-0 2017 Circulating interleukin-18 (IL-18) is a predictor of response to gemcitabine based chemotherapy in patients with pancreatic adenocarcinoma. gemcitabine 65-76 interleukin 18 Homo sapiens 28-33 28087305-9 2017 The baseline serum IL-18 levels were significantly higher in patients with PA than in the control group (p < 0.001). Protactinium 75-77 interleukin 18 Homo sapiens 19-24 28087305-13 2017 CONCLUSION: Serum levels of IL-18 can be a good diagnostic and predictive marker; especially for predicting the response to gemcitabine based CTx in patients with PA but it has no prognostic role. gemcitabine 124-135 interleukin 18 Homo sapiens 28-33 28087305-13 2017 CONCLUSION: Serum levels of IL-18 can be a good diagnostic and predictive marker; especially for predicting the response to gemcitabine based CTx in patients with PA but it has no prognostic role. Protactinium 163-165 interleukin 18 Homo sapiens 28-33 27543731-0 2017 Interleukin-18 correlates with interleukin-4 but not interferon-gamma production in lymphocyte cultures from atopic dermatitis patients after staphylococcal enterotoxin B stimulation. Boron 169-170 interleukin 18 Homo sapiens 0-14 28738323-5 2017 RESULTS: H2S attenuated FFA-induced cell apoptosis, and reduced the expression of NLRP3, ASC, pro-caspase-1, caspase-1, IL- 1beta, IL-18 and caspase-3. Hydrogen Sulfide 9-12 interleukin 18 Homo sapiens 131-136 27845246-6 2017 Whereas palmitate did not prime the NLRP3 inflammasome, it induced activation in LPS-primed cardiac fibroblasts as indicated by IL-1beta, IL-18 production and NLRP3-ASC co-localization. Palmitates 8-17 interleukin 18 Homo sapiens 138-143 27689692-5 2017 These results demonstrate that Schizandrin B can regulate the function of decreasing intracellular SOD"s activity and increasing the expression level of MDA in HaCaT cells result from the guidance of UVB, and it markedly reduced the production of inflammatory factors such as Cox-2, IL-6 or IL-18, decreased the expression level of MMP-1, and interdicted degradation process of collagens in UVB-radiated cells. schizandrin B 31-44 interleukin 18 Homo sapiens 291-296 27888626-0 2016 Interleukin-18 deteriorates Fabry cardiomyopathy and contributes to the development of left ventricular hypertrophy in Fabry patients with GLA IVS4+919 G>A mutation. gamma-Linolenic Acid 139-142 interleukin 18 Homo sapiens 0-14 28246425-2 2017 The influence of interleukin-10 (IL-10) and interleukin-18 (IL-18) polymorphisms on tacrolimus pharmacokinetics had been described in liver and kidney transplantation. Tacrolimus 84-94 interleukin 18 Homo sapiens 44-58 28246425-2 2017 The influence of interleukin-10 (IL-10) and interleukin-18 (IL-18) polymorphisms on tacrolimus pharmacokinetics had been described in liver and kidney transplantation. Tacrolimus 84-94 interleukin 18 Homo sapiens 60-65 28246425-10 2017 IL-18 rs5744247 allele C and rs1946518 allele A were associated with fast tacrolimus metabolism. Tacrolimus 74-84 interleukin 18 Homo sapiens 0-5 28246425-11 2017 Combined analysis showed that the numbers of low IL-18 mRNA expression alleles had positive correlation with tacrolimus C/D ratios in lung transplant recipients. Tacrolimus 109-119 interleukin 18 Homo sapiens 49-54 28246425-12 2017 The influence of IL-18 polymorphisms on tacrolimus C/D ratios was observed in CYP3A5 expresser recipients, but not in CYP3A5 nonexpresser recipients. Tacrolimus 40-50 interleukin 18 Homo sapiens 17-22 28246425-15 2017 IL-18 polymorphisms may influence tacrolimus elimination in lung transplantation patients. Tacrolimus 34-44 interleukin 18 Homo sapiens 0-5 29276908-0 2017 [Correlations of IL-18 and IL-6 with sodium consumption in patients with arterial hypertension and diabetes mellitus]. Sodium 37-43 interleukin 18 Homo sapiens 17-22 29276908-1 2017 AIM: To determine correlations of AH-associated interleukins (IL-18, IL-6) with sodium consumption in AH patients with and without DM. Sodium 80-86 interleukin 18 Homo sapiens 34-67 27833015-6 2016 Our data showed that TMAO significantly triggered oxidative stress and activated TXNIP-NLRP3 inflammasome whereat inflammatory cytokines interleukin (IL)-1beta and IL-18 were released in a dose- and time-dependent manner, but endothelial nitric oxide synthase (eNOS) and production of nitric oxide (NO) were inhibited. trimethyloxamine 21-25 interleukin 18 Homo sapiens 164-169 27833015-6 2016 Our data showed that TMAO significantly triggered oxidative stress and activated TXNIP-NLRP3 inflammasome whereat inflammatory cytokines interleukin (IL)-1beta and IL-18 were released in a dose- and time-dependent manner, but endothelial nitric oxide synthase (eNOS) and production of nitric oxide (NO) were inhibited. Nitric Oxide 238-250 interleukin 18 Homo sapiens 164-169 27794001-7 2016 CD169+ SIGNR1+ subcapsular medullary macrophages are the primary cells to take up GLA-SE after immunization and are critical for the innate immune responses, including rapid IL-18 production, induced by GLA-SE. gamma-Linolenic Acid 203-206 interleukin 18 Homo sapiens 174-179 27794001-8 2016 Depletion of subcapsular macrophages (SCMf) or abrogation of IL-18 signaling dramatically impairs the Ag-specific B cell and Ab responses augmented by GLA-SE. gamma-Linolenic Acid 151-154 interleukin 18 Homo sapiens 61-66 27794001-10 2016 Thus the GLA-SE adjuvant operates through interaction with IL-18-producing SCMf for the rapid induction of B cell expansion and differentiation, Ab secretion, and Th1 responses, whereas augmentation of TFH numbers by GLA-SE is independent of SCMf. Monophosphoryl lipid A (synthetic) 9-15 interleukin 18 Homo sapiens 59-64 27809669-8 2016 The IL18 SNPs were not associated with PCOS per se, but IL18-137 C and G alleles were related to the protection of insulin resistance and glucose tolerance, respectively. Glucose 138-145 interleukin 18 Homo sapiens 56-60 27624102-0 2016 Saturated fatty acids activate caspase-4/5 in human monocytes, triggering IL-1beta and IL-18 release. Fatty Acids 0-21 interleukin 18 Homo sapiens 87-92 27877060-6 2016 RESULTS: In a keratinocyte model, ES0 inhibited the expression of the inflammatory mediators, thymic stromal lymphopoietin, interleukin (IL)-18, IL-4R, IL-8, monocyte chemoattractant protein-3, macrophage inflammatory protein-3alpha, and macrophage-derived chemokine and induced the expression of involucrin, which is involved in skin barrier keratinocyte terminal differentiation. 2-amino-1H-Benzimidazol-7-ol 34-37 interleukin 18 Homo sapiens 124-143 27624102-11 2016 Palmitate, but not palmitoleate, increased caspase activity in parallel to the release of IL-1beta and IL-18. Palmitates 0-9 interleukin 18 Homo sapiens 103-108 27624102-13 2016 Notably, selective gene silencing or inhibition of caspase-4/5 reduced palmitate-induced release of IL-1beta and IL-18. Palmitates 71-80 interleukin 18 Homo sapiens 113-118 27669761-0 2016 Early effects of fluoro-edenite: correlation between IL-18 serum levels and pleural and parenchymal abnormalities. fluor-edenite 17-31 interleukin 18 Homo sapiens 53-58 27669761-6 2016 Pearson correlation showed a significant association (p < 0.0001) between IL-18 and PPs and parenchymal abnormality scores. pps 87-90 interleukin 18 Homo sapiens 77-82 27624102-6 2016 We hypothesized that 1) human monocytes from obese patients show caspase activation, and 2) fatty acids trigger this response and consequent release of IL-1beta/IL-18. Fatty Acids 92-103 interleukin 18 Homo sapiens 161-166 28855931-11 2016 CONCLUSION: Urinary interleukin 18 to urine creatinine ratio at 24 h post-transplantation, along with traditional markers such as relative fall in serum creatinine, urine output and other risk factors for delayed graft function, increased the ability to predict delayed graft function. Creatinine 44-54 interleukin 18 Homo sapiens 20-34 27788256-8 2016 High extracellular NaCl induced NLRP3 and pro-IL-1beta gene expression, while the gene expression of further inflammasome-associated proteins (NLRP1, NLRP2, NLRP6, NLRP7, NLRP12, NLRC4, AIM2, ASC, procaspase-1, pro-IL-18) was not altered or below the detection threshold. Sodium Chloride 19-23 interleukin 18 Homo sapiens 215-220 27788256-12 2016 High NaCl also induced secretion of IL-18. Sodium Chloride 5-9 interleukin 18 Homo sapiens 36-41 27731349-3 2016 Here, we identified that HG (30 mM glucose for 48 h) induced the activation of the NLRP3-ASC inflammasome, leading to caspase-1 activation, and IL-1beta and IL-18 secretion in human monocytic cell lines. Glucose 35-42 interleukin 18 Homo sapiens 157-162 27694492-4 2016 We show that the KD-associated genetic polymorphism in inositol-triphosphate 3-kinase C (ITPKC) (rs28493229) has important functional consequences, governing ITPKC protein levels and thereby intracellular calcium, which in turn regulates NLRP3 expression and production of IL-1beta and IL-18. Calcium 205-212 interleukin 18 Homo sapiens 286-291 27619996-7 2016 Exogenous IL-18 enhanced the gammadelta T cell expansion with all three stimuli, remarkably also in response to CD4 T cells and neutrophils preincubated with anti-CD277 mAb or HMBPP. 4-hydroxy-3-methylbut-2-enyl pyrophosphate 176-181 interleukin 18 Homo sapiens 10-15 27522258-9 2016 Moreover, Bakkenolide A was found to inhibit inflammation, induce apoptosis and cell death in leukemia cells via PI3K-regulated signaling pathway, down-regulating IKKs expression and suppressing in proinflammatory cytokines of IL-1beta, IL-18 and TNF-alpha. bakkenolide A 10-23 interleukin 18 Homo sapiens 237-242 28855931-11 2016 CONCLUSION: Urinary interleukin 18 to urine creatinine ratio at 24 h post-transplantation, along with traditional markers such as relative fall in serum creatinine, urine output and other risk factors for delayed graft function, increased the ability to predict delayed graft function. Creatinine 153-163 interleukin 18 Homo sapiens 20-34 27219123-1 2016 INTRODUCTION: Gout is considered to be an autoinflammatory disease and the presence of monosodium urate (MSU) crystals stimulates activation of NPRL3 inflammasome and subsequently caspase-1, generating production of active IL-1beta and IL-18. Uric Acid 87-103 interleukin 18 Homo sapiens 236-241 27352267-3 2016 This study investigated the impact of SNP at IL-10.rs1800896 (at position -1082) and IL-18.rs1946518 genes (at position -607) on the response to PEG-IFN/RBV therapy in HCV-infected Egyptians. peg-ifn 145-152 interleukin 18 Homo sapiens 85-90 27388883-8 2016 Treatment with 5-ASA after burn injury prevented the burn-induced increase in permeability, partially restored normal intestinal transit, normalized the levels of the proinflammatory cytokines IL-6 and IL-18, and restored tight junction protein expression of claudin-4 and occludin compared with that of sham levels. Mesalamine 15-20 interleukin 18 Homo sapiens 202-207 27421702-4 2016 NKBs had unique features that differed from T and B cells, and produced interleukin-18 (IL-18) and IL-12 at an early phase of infection. nkbs 0-4 interleukin 18 Homo sapiens 72-86 27421702-4 2016 NKBs had unique features that differed from T and B cells, and produced interleukin-18 (IL-18) and IL-12 at an early phase of infection. nkbs 0-4 interleukin 18 Homo sapiens 88-93 27281302-5 2016 RESULTS: Supplementation with DHA compared with supplementation with EPA led to a greater reduction in interleukin-18 (IL-18) (-7.0% +- 2.8% compared with -0.5% +- 3.0%, respectively; P = 0.01) and a greater increase in adiponectin (3.1% +- 1.6% compared with -1.2% +- 1.7%, respectively; P < 0.001). Docosahexaenoic Acids 30-33 interleukin 18 Homo sapiens 103-117 27281302-5 2016 RESULTS: Supplementation with DHA compared with supplementation with EPA led to a greater reduction in interleukin-18 (IL-18) (-7.0% +- 2.8% compared with -0.5% +- 3.0%, respectively; P = 0.01) and a greater increase in adiponectin (3.1% +- 1.6% compared with -1.2% +- 1.7%, respectively; P < 0.001). Docosahexaenoic Acids 30-33 interleukin 18 Homo sapiens 119-124 27281302-5 2016 RESULTS: Supplementation with DHA compared with supplementation with EPA led to a greater reduction in interleukin-18 (IL-18) (-7.0% +- 2.8% compared with -0.5% +- 3.0%, respectively; P = 0.01) and a greater increase in adiponectin (3.1% +- 1.6% compared with -1.2% +- 1.7%, respectively; P < 0.001). Eicosapentaenoic Acid 69-72 interleukin 18 Homo sapiens 103-117 27281302-5 2016 RESULTS: Supplementation with DHA compared with supplementation with EPA led to a greater reduction in interleukin-18 (IL-18) (-7.0% +- 2.8% compared with -0.5% +- 3.0%, respectively; P = 0.01) and a greater increase in adiponectin (3.1% +- 1.6% compared with -1.2% +- 1.7%, respectively; P < 0.001). Eicosapentaenoic Acid 69-72 interleukin 18 Homo sapiens 119-124 27219123-1 2016 INTRODUCTION: Gout is considered to be an autoinflammatory disease and the presence of monosodium urate (MSU) crystals stimulates activation of NPRL3 inflammasome and subsequently caspase-1, generating production of active IL-1beta and IL-18. Uric Acid 105-108 interleukin 18 Homo sapiens 236-241 27219123-7 2016 Levels of IL-18 were significantly higher in patients in relation to the CG (p = 0.0013). cysteinylglycine 73-75 interleukin 18 Homo sapiens 10-15 27108914-6 2016 However, 1 month after stent implantation, levels of IL-10 and IL-18 were markedly reduced in the high- and low-dose tripterygium glycosides groups compared with controls. Glycosides 130-140 interleukin 18 Homo sapiens 63-68 27398022-5 2016 Urinary IL-18 levels increased significantly at three hours (10.7 vs. 7.3 ng/mg creatinine; P < 0.05). Creatinine 80-90 interleukin 18 Homo sapiens 8-13 27398022-9 2016 CONCLUSIONS: Urinary IL-18 and NAG levels increased transiently after administration of gadolinium-based contrast agents in patients with normal renal function. Gadolinium 88-98 interleukin 18 Homo sapiens 21-26 26438531-0 2016 Increased IL18 mRNA levels in peripheral artery disease and its association with triglyceride and LDL cholesterol levels: a pilot study. Triglycerides 81-93 interleukin 18 Homo sapiens 10-14 26438531-0 2016 Increased IL18 mRNA levels in peripheral artery disease and its association with triglyceride and LDL cholesterol levels: a pilot study. Cholesterol 102-113 interleukin 18 Homo sapiens 10-14 26438531-9 2016 IL18 mRNA levels were significantly correlated with triglycerides and LDL cholesterol levels in PAD patients (p = 0.003, p = 0.014, respectively). Triglycerides 52-65 interleukin 18 Homo sapiens 0-4 26438531-9 2016 IL18 mRNA levels were significantly correlated with triglycerides and LDL cholesterol levels in PAD patients (p = 0.003, p = 0.014, respectively). Cholesterol 74-85 interleukin 18 Homo sapiens 0-4 26438531-10 2016 HDL cholesterol levels were negatively correlated with IL18 mRNA levels in controls (p = 0.05). Cholesterol 4-15 interleukin 18 Homo sapiens 55-59 26438531-11 2016 This report is a preliminary study to show an association between IL18, IL18BP mRNA levels and PAD and suggests that the IL18 gene may have a significant relationship with triglyceride and LDL cholesterol levels in PAD patients. Triglycerides 172-184 interleukin 18 Homo sapiens 66-70 26538631-8 2016 Urine KIM-1/creatinine and IL-18/creatinine independently associated with greater risk of death (aHR, 1.29; 95% CI, 1.03 to 1.61 and aHR, 1.25; 95% CI, 1.04 to 1.49 per log increase, respectively) but not with risk of cardiovascular events or graft failure. Creatinine 33-43 interleukin 18 Homo sapiens 27-32 27287410-5 2016 Indeed, macrophage depletion or the absence of the NLRP3 inflammasome, the adaptor protein ASC or interleukin-18 (IL-18) abolished monobenzone CHS, thereby establishing a non-redundant role for the NLRP3 inflammasome as a critical proinflammatory checkpoint in the induction of hapten-dependent memory NK cells. monobenzone 131-142 interleukin 18 Homo sapiens 98-112 27287410-5 2016 Indeed, macrophage depletion or the absence of the NLRP3 inflammasome, the adaptor protein ASC or interleukin-18 (IL-18) abolished monobenzone CHS, thereby establishing a non-redundant role for the NLRP3 inflammasome as a critical proinflammatory checkpoint in the induction of hapten-dependent memory NK cells. monobenzone 131-142 interleukin 18 Homo sapiens 114-119 27082857-15 2016 Leptin-induced IL-18 expression was regulated via NF-kappaB/NF-kappaB1 signaling in TAMs, while via PI3K-AKT/ATF-2 signaling in breast cancer cells, which, eventually, lead to invasion and metastasis of breast cancer cells. tams 84-88 interleukin 18 Homo sapiens 15-20 27058587-2 2016 IL-18 and IL12 elevation has been associated with atherosclerosis, and their interaction is hypothesized to partly be driven by glucose. Glucose 128-135 interleukin 18 Homo sapiens 0-5 27058587-3 2016 We aimed to explore if simultaneous elevation of IL-18 and IL-12, as related to glucose levels, would influence the prognosis in coronary artery disease (CAD). Glucose 80-87 interleukin 18 Homo sapiens 49-54 26132511-2 2016 In clinical studies candidate markers such as kidney injury molecule-1, neutrophil gelatinase-associated lipocalin and interleukin-18 have been demonstrated to be valid biomarkers with high predictive value for DFG in a post-transplant setting. 1,3-Diphenylguanidine 211-214 interleukin 18 Homo sapiens 119-133 26905640-3 2016 OBJECTIVES: To estimate C-reactive protein (CRP), interleukin (IL)-18, and cortisol levels in patients with CU and to explore their association with disease severity and stress. Copper 108-110 interleukin 18 Homo sapiens 50-69 26905640-9 2016 We further observed that patients with CU with hypocortisolism had higher levels of hs-CRP and IL-18 and higher PSLE and DHUS-R scores compared with those without hypocortisolism. Copper 39-41 interleukin 18 Homo sapiens 95-100 26930607-4 2016 Preliminary efficacy, safety and tolerability, pharmacokinetics, and pharmacodynamics of the anti-IL-18 monoclonal antibody, GSK1070806, were assessed. GSK1070806 125-135 interleukin 18 Homo sapiens 98-103 27105502-8 2016 The in vitro study showed that MALT1 inhibitors decreased production of IL-1beta/IL-18 in phorbol myristate acetate-differentiated THP-1 cells and bone marrow derived macrophage via suppressing the activation of NF-kappaB and NLRP3 inflammasome. Tetradecanoylphorbol Acetate 90-115 interleukin 18 Homo sapiens 81-86 26865578-3 2016 Baicalin at 50 microg/ml and 100 microg/ml could inhibit the production of ROS, TNF-alpha, IL-1beta and IL-18, and down-regulate mRNA expression of IL-1beta, IL-18, TNF-alpha and NLRP3, as well as expression of cleaved caspase-1 p20. baicalin 0-8 interleukin 18 Homo sapiens 104-109 26865578-3 2016 Baicalin at 50 microg/ml and 100 microg/ml could inhibit the production of ROS, TNF-alpha, IL-1beta and IL-18, and down-regulate mRNA expression of IL-1beta, IL-18, TNF-alpha and NLRP3, as well as expression of cleaved caspase-1 p20. baicalin 0-8 interleukin 18 Homo sapiens 158-163 27471628-0 2016 AIM2 inflammasome mediates Arsenic-induced secretion of IL-1 beta and IL-18. Arsenic 27-34 interleukin 18 Homo sapiens 70-75 27471628-7 2016 The data from current study show sub-chronic arsenic exposure activates AIM2 inflammasome which in turn activates caspase-1 and enhances the secretion of IL-1beta and IL-18 in HaCaT cells and the skin of BALB/c mice. Arsenic 45-52 interleukin 18 Homo sapiens 167-172 27471628-8 2016 In addition, arsenic-promoted activation of AIM2 inflammasome and increase of IL-1beta/IL-18 production are inhibited by PKR inhibitor in HaCaT cells or in the skin of PKR mutant mice, indicating a potential role of PKR in arsenic-induced sterile inflammation. Arsenic 13-20 interleukin 18 Homo sapiens 87-92 26743485-5 2016 Interestingly, RA-UIP BALF cell cultures treated with lipopolysaccharide/ATP showed a potent stimulation of IL-18 secretion but not IL-1beta, the latter being already elevated in the unstimulated cultures, while examination of the intracellular IL-1beta levels in RA-UIP BALF cells upon NLRP3 inflammasome stimulation showed a significant upregulation of IL-1beta suggesting the NLRP3 pathway could be further activated.Taken together, our results suggest distinct inflammasome activation profiles between autoimmune and idiopathic lung fibrosis. Adenosine Triphosphate 73-76 interleukin 18 Homo sapiens 108-113 26640965-6 2016 Our study shows that tianeptine attenuated the LPS-evoked inflammatory activation of microglia by decreasing the expression of proinflammatory cytokines such as IL-1beta, IL-18, IL-6 and tumor necrosis factor alpha (TNF-alpha), the release of nitric oxide (NO) and reactive oxygen species (ROS) as well as the expression of inducible nitric oxide synthase. tianeptine 21-31 interleukin 18 Homo sapiens 171-176 26853432-7 2016 The PD inducer rotenone could activate neuronal inflammasomes and promote the maturation and secretion of the cleaved IL-1beta and IL-18 in a dose- and time-dependent manner. Rotenone 15-23 interleukin 18 Homo sapiens 131-136 26928328-3 2016 Here, we show that VTX-2337 stimulates the release of mature IL-1beta and IL-18 from monocytic cells through coordinated actions on both TLR8 and the NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome complex. VTX-2337 19-27 interleukin 18 Homo sapiens 74-79 26555265-5 2016 Furthermore, our data suggest that the ASC-NLRP3 inflammasome is responsible for QS-21-induced IL-1beta/IL-18 release. saponin QA-21V1 81-86 interleukin 18 Homo sapiens 104-109 27997912-9 2016 Results from the Spearman correlation analysis showed that levels of the miR-1 were negatively correlated with FS and EF, while levels of the cTnI, IL-18, TNF-alpha and miR-146b were positively correlated with FS and EF. phenylalanylserine 210-212 interleukin 18 Homo sapiens 148-153 26555265-4 2016 We observed QS-21 to elicit caspase-1-dependent IL-1beta and IL-18 release in antigen-presenting cells such as macrophages and dendritic cells when co-stimulated with the TLR4-agonist adjuvant monophosphoryl lipid A. saponin QA-21V1 12-17 interleukin 18 Homo sapiens 61-66 26711576-3 2016 Comparing GA with differently-manufactured glatiramoid Polimunol (Synthon) in mice yielded hundreds of differentially expressed probesets, including biologically-relevant genes (e.g. Il18, adj p<9e-6) and pathways. glatiramoid polimunol 43-64 interleukin 18 Homo sapiens 183-187 26602157-7 2016 Manumycin A also inhibited IL-18 release from THP-1 cells, while in cultures of blood monocytes, this cytokine was not detectable. manumycin 0-11 interleukin 18 Homo sapiens 27-32 26889257-3 2016 The aim of the present study was to determine whether alterations in inflammasome gene expression may be responsible for the modified IL-1beta and IL-18 secretion following lipopolysaccharide (LPS) and catecholamine co-stimulation. Catecholamines 202-215 interleukin 18 Homo sapiens 147-152 26307433-5 2015 IVIG also potentiated NK cell proliferation with IL-12, IL-15 and IL-18. ivig 0-4 interleukin 18 Homo sapiens 66-71 26638072-3 2015 Here, we demonstrate that the microbiota-associated metabolites taurine, histamine, and spermine shape the host-microbiome interface by co-modulating NLRP6 inflammasome signaling, epithelial IL-18 secretion, and downstream anti-microbial peptide (AMP) profiles. Taurine 64-71 interleukin 18 Homo sapiens 191-196 26638072-3 2015 Here, we demonstrate that the microbiota-associated metabolites taurine, histamine, and spermine shape the host-microbiome interface by co-modulating NLRP6 inflammasome signaling, epithelial IL-18 secretion, and downstream anti-microbial peptide (AMP) profiles. Spermine 88-96 interleukin 18 Homo sapiens 191-196 26307433-7 2015 IVIG also enhanced interferon-gamma production with IL-2, IL-12 and IL-18. ivig 0-4 interleukin 18 Homo sapiens 68-73 26474654-11 2015 Isolated PBMCs with IL-18 -137GC/CC genotype were able to produce a higher level of IL-18 than those with IL-18 -137GG genotype, either spontaneously or in response to PMA plus calcimycin A23187. Calcimycin 177-194 interleukin 18 Homo sapiens 20-25 26474654-11 2015 Isolated PBMCs with IL-18 -137GC/CC genotype were able to produce a higher level of IL-18 than those with IL-18 -137GG genotype, either spontaneously or in response to PMA plus calcimycin A23187. Calcimycin 177-194 interleukin 18 Homo sapiens 84-89 26474654-11 2015 Isolated PBMCs with IL-18 -137GC/CC genotype were able to produce a higher level of IL-18 than those with IL-18 -137GG genotype, either spontaneously or in response to PMA plus calcimycin A23187. Calcimycin 177-194 interleukin 18 Homo sapiens 84-89 26589393-3 2015 This study aims to examine the serum TNF-alpha, IL-6 and IL-18 levels in chronic human ketamine users as compared to healthy subjects. Ketamine 87-95 interleukin 18 Homo sapiens 57-62 26324406-7 2015 Lowering the habitually high PA intake by feeding the HOA diet resulted in lower secretion of interleukin (IL)-1beta, IL-18, IL-10, and tumor necrosis factor-alpha by PBMCs, as well as lower relative mRNA expression of cJun and NLRP3 in muscle. Palmitic Acid 29-31 interleukin 18 Homo sapiens 118-123 26589393-11 2015 CONCLUSIONS: Serum levels of TNF-alpha, IL-6 and IL-18 were altered in chronic ketamine abusers which may play a role in schizophrenia-like symptoms in chronic ketamine abusers. Ketamine 79-87 interleukin 18 Homo sapiens 49-54 26589393-11 2015 CONCLUSIONS: Serum levels of TNF-alpha, IL-6 and IL-18 were altered in chronic ketamine abusers which may play a role in schizophrenia-like symptoms in chronic ketamine abusers. Ketamine 160-168 interleukin 18 Homo sapiens 49-54 26346467-10 2015 The IL-18 -137 G/C polymorphism was significantly associated with an increased risk of RPL under a recessive genetic model (CC vs. GG + CG: odds ratio = 1.56, 95% confidence interval = 1.13 ~ 2.15). cysteinylglycine 136-138 interleukin 18 Homo sapiens 4-9 24724613-0 2015 Interleukin-18 as a target for modulation of irinotecan-induced intestinal toxicity: a step towards a better therapeutic index? Irinotecan 45-55 interleukin 18 Homo sapiens 0-14 26101092-6 2015 The patients with IL-18 dominant subset at their disease onset were significantly more likely to develop MAS after TCZ therapy started. tioconazole 115-118 interleukin 18 Homo sapiens 18-23 26168332-7 2015 Inhibition of caspase-1 activation using the specific inhibitor YVAD identified a homogenous non responder group featuring a caspase-1-independent IL-18/IFN-gamma response, and a heterogenous responder group, in which both IL-18 and IFN-gamma responses were caspase-1-dependent, with a 40-70% range of inhibition by YVAD. YVAD 64-68 interleukin 18 Homo sapiens 147-152 25880879-8 2015 An IL-18-dependent aberrant expression of IL-22R1 on cells of haematopoietic origin seems to be a specific immunological signature of patients with pSS and pSS-associated lymphomas. pss 148-151 interleukin 18 Homo sapiens 3-8 26304941-2 2015 Colchicine is believed to block the NLRP3 inflammasome, a cytosolic complex responsible for the production of IL-1beta and IL-18. Colchicine 0-10 interleukin 18 Homo sapiens 123-128 26304941-10 2015 Colchicine administration significantly reduced transcoronary gradients of all 3 cytokines in ACS patients by 40% to 88% (P=0.028, 0.032, and 0.032, for IL-1beta, IL-18, and IL-6, respectively). Colchicine 0-10 interleukin 18 Homo sapiens 163-168 26212544-2 2015 In this study, we investigated the possible modulation by levornidazole of NOD-like receptor protein 3 (NLRP3) inflammasome-mediated IL-1beta and IL-18 release from macrophages. Ornidazole Levo- 58-71 interleukin 18 Homo sapiens 146-151 26212544-4 2015 Surprisingly, an in vitro study showed that levornidazole suppressed IL-1beta and IL-18 secretion by blocking the activation of the NLRP3 inflammasome. Ornidazole Levo- 44-57 interleukin 18 Homo sapiens 82-87 25880879-8 2015 An IL-18-dependent aberrant expression of IL-22R1 on cells of haematopoietic origin seems to be a specific immunological signature of patients with pSS and pSS-associated lymphomas. pss 156-159 interleukin 18 Homo sapiens 3-8 25575547-6 2015 AAP (0.5-1.0 mM) and NAC (0.5-1.0 mM) used individually or in combination could down-regulate protein expression of cleaved caspase-1 and mRNA expression of IL-1beta, IL-18 and NLRP3. Acetaminophen 0-3 interleukin 18 Homo sapiens 167-172 25575547-6 2015 AAP (0.5-1.0 mM) and NAC (0.5-1.0 mM) used individually or in combination could down-regulate protein expression of cleaved caspase-1 and mRNA expression of IL-1beta, IL-18 and NLRP3. Acetylcysteine 21-24 interleukin 18 Homo sapiens 167-172 25616404-8 2015 The Kyn/Trp ratio was positively associated with CD8(+) T-cell activation and levels of inflammatory cytokines (interleukin 6, interferon gamma-inducible protein 10, interleukin 18, and tumor necrosis factor alpha) and negatively associated with dendritic cell frequencies at baseline and in untreated patients. Tryptophan 8-11 interleukin 18 Homo sapiens 166-180 26427112-10 2015 Within 1 day of the procedure, urine levels of KIM-1, NGAL and IL-18 in patients in the intensive DCXC therapy group were lower than those in the basic treatment group and standard therapy group (P < 0.05). dcxc 98-102 interleukin 18 Homo sapiens 63-68 26053021-10 2015 The cytokine determination showed that monocytes from women with PE produced higher endogenous levels of IL-1beta, IL-18 and TNF-alpha compared to the other groups, while the stimulus with MSU led to higher production of these cytokines in preeclamptic group than in the NT group. Uric Acid 189-192 interleukin 18 Homo sapiens 115-120 26005910-8 2015 Moreover, Ang II-induced increases in the expression of NLRP3, ASC, caspase-1, IL-1beta, and IL-18 were significantly inhibited by pretreatment with the ERS inhibitor 4-PBA (5 mmol/L). 4-phenylbutylamine 167-172 interleukin 18 Homo sapiens 93-98 26942065-4 2016 Upon ibrutinib treatment, LPS-treated DCs displayed lower synthesis of TNF-alpha and nitric oxide (NO) and higher induction of IL-6, TGF-beta, IL-10 and IL-18. ibrutinib 5-14 interleukin 18 Homo sapiens 153-158 25801692-6 2015 However, overall significant decreases in MCP-1, PAI-1, MMP-9, IL-18 and IL-6, and increases in adropin and osteocrin plasma concentrations occurred after T&A. t& 155-160 interleukin 18 Homo sapiens 63-68 25834143-0 2015 Helicobacter pylori induces IL-1beta and IL-18 production in human monocytic cell line through activation of NLRP3 inflammasome via ROS signaling pathway. Reactive Oxygen Species 132-135 interleukin 18 Homo sapiens 41-46 26057800-5 2015 In this study, surface-entropy reduction (SER) and rational protein design were employed to facilitate the crystallization of hIL-18. Serine 42-45 interleukin 18 Homo sapiens 126-132 25834143-9 2015 Furthermore, NAC treatment could inhibit NLRP3 inflammasome formation and caspase-1 activation and suppress the release of IL-1beta and IL-18 from H. pylori-infected THP-1 cells. Acetylcysteine 13-16 interleukin 18 Homo sapiens 136-141 25840484-10 2015 RESULTS: Patients with SRA had significantly lower IL-18 levels in sputum supernatants compared to mild asthmatics (p < 0.001). Adenosine 5'-phosphorothioate 23-26 interleukin 18 Homo sapiens 51-56 25770182-5 2015 Here, we demonstrated that CO inhibited caspase-1 activation and the secretion of IL-1beta and IL-18 in response to lipopolysaccharide (LPS) and ATP treatment in bone marrow-derived macrophages. Adenosine Triphosphate 145-148 interleukin 18 Homo sapiens 95-100 25770182-6 2015 CO also inhibited IL-18 secretion in response to LPS and nigericin treatment, another NLRP3 inflammasome activation model. Nigericin 57-66 interleukin 18 Homo sapiens 18-23 25978411-5 2015 We found that NS1 proteins derived from both highly pathogenic and low pathogenic strains efficiently decreased secretion of IL-1beta and IL-18 from THP-1 cells treated with LPS and ATP. Adenosine Triphosphate 182-185 interleukin 18 Homo sapiens 138-143 25840484-15 2015 The decreased levels of IL-18 in SRA support the hypothesis of deregulated inflammasome activation, justifying the susceptibility of these patients for bacterial colonization or infection. Adenosine 5'-phosphorothioate 33-36 interleukin 18 Homo sapiens 24-29 25591548-6 2015 IL-18 expression upregulated the expression and phosphorylation of glycogen synthase kinase (GSK)-3beta protein in CRL1623 cells, whereas the selective GSK-3beta inhibitor kenpaullone antagonized the effects of IL-18 protein on TSCC cells in vitro. kenpaullone 172-183 interleukin 18 Homo sapiens 0-5 25798846-5 2015 Additionally, elevated mitochondrial ROS level, colocalization of NLRP3/ASC/mitochondria in peripheral blood mononuclear cells from CKD-HD patients and down-regulation of CASP-1, IL1-beta and IL-18 protein levels in immune-cells of CKD-HD patients stimulated with LPS/ATP in presence of mitoTEMPO, inhibitor of mitochondrial ROS production, suggested a possible role of this organelle in the aforementioned CKD-associated inflammasome activation. Adenosine Triphosphate 268-271 interleukin 18 Homo sapiens 192-197 25798846-5 2015 Additionally, elevated mitochondrial ROS level, colocalization of NLRP3/ASC/mitochondria in peripheral blood mononuclear cells from CKD-HD patients and down-regulation of CASP-1, IL1-beta and IL-18 protein levels in immune-cells of CKD-HD patients stimulated with LPS/ATP in presence of mitoTEMPO, inhibitor of mitochondrial ROS production, suggested a possible role of this organelle in the aforementioned CKD-associated inflammasome activation. ros 325-328 interleukin 18 Homo sapiens 192-197 25730877-5 2015 In CAPS monocytes, LPS induces the externalization of copious amounts of ATP (10-fold), which drive IL-1beta, IL-18, and IL-1alpha release via activation of the P2X purinoceptor 7. Adenosine Triphosphate 73-76 interleukin 18 Homo sapiens 110-115 24766056-8 2015 In patients with mild ALD, 1 week of alcohol withdrawal was sufficient to decrease expression level of total macrophage markers in the adipose tissue, to orient adipose tissue macrophages (ATM) towards an anti-inflammatory M2 phenotype and to decrease the mRNA expression of cytokines/chemokines (IL18, CCL2, osteopontin, semaphorin 7A). Alcohols 37-44 interleukin 18 Homo sapiens 297-301 25686106-9 2015 BHB reduces NLRP3 inflammasome-mediated interleukin (IL)-1beta and IL-18 production in human monocytes. 3-Hydroxybutyric Acid 0-3 interleukin 18 Homo sapiens 67-72 25591548-6 2015 IL-18 expression upregulated the expression and phosphorylation of glycogen synthase kinase (GSK)-3beta protein in CRL1623 cells, whereas the selective GSK-3beta inhibitor kenpaullone antagonized the effects of IL-18 protein on TSCC cells in vitro. kenpaullone 172-183 interleukin 18 Homo sapiens 211-216 25699211-21 2015 Our findings suggest that total cholesterol levels positively regulate IL-18, while HDL cholesterol and apolipoprotein A1 may reduce IL-12 p40 and IL-18 binding protein levels. Cholesterol 88-99 interleukin 18 Homo sapiens 147-152 25678688-0 2015 Inflammasomes Induced by 7-Ketocholesterol and Other Stimuli in RPE and in Bone Marrow-Derived Cells Differ Markedly in Their Production of IL-1beta and IL-18. 7-ketocholesterol 25-42 interleukin 18 Homo sapiens 153-158 25699211-3 2015 High levels or modified forms of cholesterol stimulate release of the inflammatory cytokines IL-12 and IL-18 that synergistically stimulate T lymphocytes to produce the atherogenic cytokine interferon-gamma. Cholesterol 33-44 interleukin 18 Homo sapiens 103-108 25699211-17 2015 We found that IL-18 levels positively correlate with total cholesterol levels (r (2) = 0.15, p < 0.03), but not HDL or LDL cholesterol. Cholesterol 59-70 interleukin 18 Homo sapiens 14-19 25699211-21 2015 Our findings suggest that total cholesterol levels positively regulate IL-18, while HDL cholesterol and apolipoprotein A1 may reduce IL-12 p40 and IL-18 binding protein levels. Cholesterol 32-43 interleukin 18 Homo sapiens 71-76 25699211-22 2015 Additional studies in a larger patient population are needed to confirm these findings, and verify mechanistically whether HDL cholesterol can directly suppress IL-12 p40 and IL-18 binding protein levels in human subjects. Cholesterol 127-138 interleukin 18 Homo sapiens 175-180 25189464-6 2015 Our results showed that kaempferol at concentrations of 12.5 and 25 mug/mL significantly suppressed the release of TNF-alpha, IL-1beta, IL-6, and IL-18 and inhibited activation of NF-kappaB and Akt in LPS plus ATP-induced cardiac fibroblasts. kaempferol 24-34 interleukin 18 Homo sapiens 146-151 25487141-0 2015 Association between interleukin-18 promoter variants and tacrolimus pharmacokinetics in Chinese renal transplant patients. Tacrolimus 57-67 interleukin 18 Homo sapiens 20-34 25487141-2 2015 This study aimed to assess the potential influence of two functional single nucleotide polymorphisms (SNPs) in the IL-18 promoter region on the tacrolimus pharmacokinetics in Chinese renal transplant patients. Tacrolimus 144-154 interleukin 18 Homo sapiens 115-120 25487141-6 2015 RESULTS: The tacrolimus C/D ratio was significantly associated with the IL-18 rs1946518 gene polymorphism in the first month after transplantation (P = 0.0225). Tacrolimus 13-23 interleukin 18 Homo sapiens 72-77 25487141-9 2015 In a simple linear regression model, age, hemoglobin (Hb), CYP3A5 gene polymorphisms, and IL-18 A-607C gene polymorphisms were associated with log-transformed tacrolimus C/D ratios (P < 0.05). Tacrolimus 159-169 interleukin 18 Homo sapiens 90-95 25487141-11 2015 CONCLUSION: Our findings suggest that a combined analysis of CYP3A5 and IL-18 promoter polymorphisms may help clinicians develop individualized tacrolimus treatment, which is based on determining CYP3A5 genotype. Tacrolimus 144-154 interleukin 18 Homo sapiens 72-77 25280773-0 2015 Hyaluronan regulates chemical allergen-induced IL-18 production in human keratinocytes. Hyaluronic Acid 0-10 interleukin 18 Homo sapiens 47-52 25280773-3 2015 The purpose of this study was to examine the role of hyaluronan (HA) degradation in IL-18 production in human keratinocytes following stimulation with the contact sensitizers 2,4-dinitrochlorobenzene (DNCB) and PPD. Hyaluronic Acid 53-63 interleukin 18 Homo sapiens 84-89 25280773-3 2015 The purpose of this study was to examine the role of hyaluronan (HA) degradation in IL-18 production in human keratinocytes following stimulation with the contact sensitizers 2,4-dinitrochlorobenzene (DNCB) and PPD. Hyaluronic Acid 65-67 interleukin 18 Homo sapiens 84-89 25280773-3 2015 The purpose of this study was to examine the role of hyaluronan (HA) degradation in IL-18 production in human keratinocytes following stimulation with the contact sensitizers 2,4-dinitrochlorobenzene (DNCB) and PPD. Dinitrochlorobenzene 175-199 interleukin 18 Homo sapiens 84-89 25280773-6 2015 Modulation of HA production, by HYAL or aristolochic acid pre-treatment, resulted in a significant reduction of contact allergen-induced IL-18 production. aristolochic acid I 40-57 interleukin 18 Homo sapiens 137-142 25599738-0 2015 Effect of N-acetyl cysteine and vitamin C on kidney allograft function biomarkers interleukin-18 and neutrophil gelatinase-associated lipocalin. Acetylcysteine 10-27 interleukin 18 Homo sapiens 82-96 25252891-5 2015 The aim of this study was to evaluate the concentration of endostatin, Cath V, and IL-18 in BALF of BBS patients. bbs 100-103 interleukin 18 Homo sapiens 83-88 25252891-9 2015 Both endostatin and IL-18 levels were higher in BBS than in the control group (0.88+-0.30 vs. 0.29+-0.04 ng/ml, p=0.028; 40.37+-31.60 vs. 14.61+-1.30 pg/ml, p=0.007, respectively). bbs 48-51 interleukin 18 Homo sapiens 20-25 25252891-10 2015 In BBS there were correlations between the levels of endostatin and IL-18 (r=0.74, p=0.001) as well as endostatin and DLCO (diffusing capacity for carbon monoxide) (r=-0.6, p=0.013). bbs 3-6 interleukin 18 Homo sapiens 68-73 25599738-9 2015 Although the levels of NGAL and IL-18 decreased in the NAC and NAC and vitamin C groups, these reductions were not significant. Acetylcysteine 55-58 interleukin 18 Homo sapiens 32-37 25599738-9 2015 Although the levels of NGAL and IL-18 decreased in the NAC and NAC and vitamin C groups, these reductions were not significant. Acetylcysteine 63-66 interleukin 18 Homo sapiens 32-37 25599738-0 2015 Effect of N-acetyl cysteine and vitamin C on kidney allograft function biomarkers interleukin-18 and neutrophil gelatinase-associated lipocalin. Ascorbic Acid 32-41 interleukin 18 Homo sapiens 82-96 25599738-9 2015 Although the levels of NGAL and IL-18 decreased in the NAC and NAC and vitamin C groups, these reductions were not significant. Ascorbic Acid 71-80 interleukin 18 Homo sapiens 32-37 25712187-0 2015 Donor IL-18 rs5744247 polymorphism as a new biomarker of tacrolimus elimination in Chinese liver transplant patients during the early post-transplantation period: results from two cohort studies. Tacrolimus 57-67 interleukin 18 Homo sapiens 6-11 25973432-3 2015 A significant association was found between aGvHD grades II-IV and SNPs of donor IL10-1082GG, and Fas-670CC + CT and recipient IL18-607 TT + TG genotype. Thioguanine 141-143 interleukin 18 Homo sapiens 127-131 25973432-6 2015 In conclusion we found an association between IL10, FAS, and TLR4 in the donor and IL18 in the recipient and an increased risk of developing aGvHD in transplanted children. ammonium ferrous sulfate 52-55 interleukin 18 Homo sapiens 83-87 25712187-1 2015 AIM: This study evaluated the relationships between IL-18 polymorphisms and tacrolimus elimination in Chinese liver transplant patients. Tacrolimus 76-86 interleukin 18 Homo sapiens 52-57 25712187-4 2015 RESULTS: In training set, daily drug dose, total bilirubin, donor CYP3A5 rs776746 and IL-18 rs5744247 genotypes were screened to construct prediction model for tacrolimus elimination. Tacrolimus 160-170 interleukin 18 Homo sapiens 86-91 25712187-6 2015 Donor IL-18 rs5744247 polymorphism was an independent predictor of tacrolimus elimination in the first week after transplantation in both training (p = 0.008) and validating cohorts (p = 0.033). Tacrolimus 67-77 interleukin 18 Homo sapiens 6-11 25712187-7 2015 CONCLUSION: Donor IL-18 rs5744247 polymorphism may influence on tacrolimus elimination. Tacrolimus 64-74 interleukin 18 Homo sapiens 18-23 25281528-6 2014 Moreover, the silencing of the Nlrp3 gene or the use of the caspase-1 inhibitor Z-VAD-fmk significantly attenuated the albumin-induced increase in IL-1beta and IL-18 expression in HK2 cells. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 80-89 interleukin 18 Homo sapiens 160-165 25448682-9 2014 The results from in vitro assays showed that fraxinellone significantly reduced lipopolysaccharide (LPS)-induced production of nitric oxide (NO), IL-1beta and IL-18 as well as the activity of iNOS in both THP-1 cells and mouse primary peritoneal macrophages. fraxinellone 45-57 interleukin 18 Homo sapiens 159-164 25960933-3 2014 We show here that Vgamma9Vdelta2 T cells pretreated with the stress-related, inflammasome-dependent cytokine interleukin 18 (IL-18) were potently activated not only by IPP but also by all downstream isoprenoid pyrophosphates that exhibit combined features of antigens and cell-extrinsic metabolic cues. isoprenoid pyrophosphates 199-224 interleukin 18 Homo sapiens 109-123 25960933-3 2014 We show here that Vgamma9Vdelta2 T cells pretreated with the stress-related, inflammasome-dependent cytokine interleukin 18 (IL-18) were potently activated not only by IPP but also by all downstream isoprenoid pyrophosphates that exhibit combined features of antigens and cell-extrinsic metabolic cues. isoprenoid pyrophosphates 199-224 interleukin 18 Homo sapiens 125-130 25091898-6 2014 In addition, we critically evaluate controversial evidence suggesting a specific role for mitochondrial reactive oxygen species in the activation of the NLRP3 inflammasome, a multiprotein complex that mediates the production of IL-1beta and IL-18. Reactive Oxygen Species 104-127 interleukin 18 Homo sapiens 241-246 25288220-7 2014 Ex vivo, AZD9056 inhibited IL-1 and IL-18 release to BzATP in LPS-primed human monocytes. AZD9056 9-16 interleukin 18 Homo sapiens 36-41 24780928-6 2014 In the case of DNCB, rotenone completely prevents the induction of IL-18, whereas for citral, DPI completely prevents the induction of IL-18. Rotenone 21-29 interleukin 18 Homo sapiens 67-72 24780928-0 2014 Role of ROS and HMGB1 in contact allergen-induced IL-18 production in human keratinocytes. Reactive Oxygen Species 8-11 interleukin 18 Homo sapiens 50-55 24780928-6 2014 In the case of DNCB, rotenone completely prevents the induction of IL-18, whereas for citral, DPI completely prevents the induction of IL-18. diphenyleneiodonium 94-97 interleukin 18 Homo sapiens 135-140 24780928-3 2014 The purpose of this study was to characterize the molecular mechanisms underlying allergen-induced IL-18 production, in order to identify the cellular source of reactive oxygen species (ROS) and the danger signals involved. Reactive Oxygen Species 161-184 interleukin 18 Homo sapiens 99-104 24780928-3 2014 The purpose of this study was to characterize the molecular mechanisms underlying allergen-induced IL-18 production, in order to identify the cellular source of reactive oxygen species (ROS) and the danger signals involved. Reactive Oxygen Species 186-189 interleukin 18 Homo sapiens 99-104 24780928-8 2014 Its sequester by glycirrizic acid significantly modulates PPD-induced IL-18 production and completely prevents DNCB- and citral-induced IL-18. glycirrizic acid 17-33 interleukin 18 Homo sapiens 70-75 24780928-5 2014 In the case of PPD, the induction of IL-18 can be modulated by rotenone, allopurinol, and DPI. Rotenone 63-71 interleukin 18 Homo sapiens 37-42 24780928-5 2014 In the case of PPD, the induction of IL-18 can be modulated by rotenone, allopurinol, and DPI. Allopurinol 73-84 interleukin 18 Homo sapiens 37-42 24780928-8 2014 Its sequester by glycirrizic acid significantly modulates PPD-induced IL-18 production and completely prevents DNCB- and citral-induced IL-18. glycirrizic acid 17-33 interleukin 18 Homo sapiens 136-141 24780928-5 2014 In the case of PPD, the induction of IL-18 can be modulated by rotenone, allopurinol, and DPI. diphenyleneiodonium 90-93 interleukin 18 Homo sapiens 37-42 24780928-8 2014 Its sequester by glycirrizic acid significantly modulates PPD-induced IL-18 production and completely prevents DNCB- and citral-induced IL-18. Dinitrochlorobenzene 111-115 interleukin 18 Homo sapiens 136-141 24780928-8 2014 Its sequester by glycirrizic acid significantly modulates PPD-induced IL-18 production and completely prevents DNCB- and citral-induced IL-18. citral 121-127 interleukin 18 Homo sapiens 136-141 24780928-9 2014 We found that different intracellular sources of ROS are triggered by contact allergens, and an important role for HMGB1 in chemical allergen-induced IL-18 production was demonstrated. Reactive Oxygen Species 49-52 interleukin 18 Homo sapiens 150-155 24623131-6 2014 Within minutes of endotoxin priming, the NLRP3 inflammasome is licensed for ATP-induced release of processed IL-18, apoptosis-associated speck-forming complex containing CARD, and active caspase-1, independent of new mRNA or protein synthesis. Adenosine Triphosphate 76-79 interleukin 18 Homo sapiens 109-114 25225670-1 2014 The nucleotide-binding oligomerization domain-like receptor pyrin domain-containing 3 (Nlrp3) inflammasome plays an important role in inflammation by controlling the maturation and secretion of the cytokines IL-1beta and IL-18 in response to multiple stimuli including pore-forming toxins, particulate matter, and ATP. Adenosine Triphosphate 314-317 interleukin 18 Homo sapiens 221-226 25109413-1 2014 OBJECTIVE: To investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of GSK1070806, a novel IgG1 mAb that neutralizes human interleukin (IL)-18. GSK1070806 94-104 interleukin 18 Homo sapiens 146-165 25109413-8 2014 Serum drug-bound IL-18 levels increased post-dosing and were sustained for a long time-period following GSK1070806 administration. GSK1070806 104-114 interleukin 18 Homo sapiens 17-22 25109413-9 2014 Ex-vivo whole blood assay demonstrated prolonged pharmacological activity of GSK1070806 as determined by its primary immunological mechanism of action, inhibition of IL-18-induced IFN-gamma production. GSK1070806 77-87 interleukin 18 Homo sapiens 166-171 25198668-14 2014 IL-18 -607AA and OPN -442TT genotypes can be used as positive predictive markers of interferon plus ribavirin treatment of HCV infection in the Pakistani population. Ribavirin 100-109 interleukin 18 Homo sapiens 0-5 25147500-3 2014 IL-18 can modulate the tau kinases, Cdk5 and GSK3beta, as well as Abeta-production. UNII-042A8N37WH 66-71 interleukin 18 Homo sapiens 0-5 24656453-5 2014 PREDICTORS: Ratios of urine KIM-1, IL-18, and albumin to creatinine (KIM-1:Cr, IL-18:Cr, and ACR, respectively). Creatinine 57-67 interleukin 18 Homo sapiens 79-84 24656453-10 2014 The top quartile of IL-18:Cr also was associated with heart failure in a model adjusted for risk factors and eGFR (HR, 1.35; 95% CI, 1.05-1.73), but was attenuated by adjustment for ACR (HR, 1.15; 95% CI, 0.89-1.48). Chromium 26-28 interleukin 18 Homo sapiens 20-25 25131111-12 2014 The CR group, AA vs CC genotype of IL18 (rs1946518), had an OR = 2.35 (P = .04). Chromium 4-6 interleukin 18 Homo sapiens 35-39 25131111-15 2014 Presence of AA genotype (IL18-rs1946518) is connected with a 2.35 times higher risk of CR occurrence. Chromium 87-89 interleukin 18 Homo sapiens 25-29 24918752-4 2014 RESULTS: All biomarker protein concentrations increased after transplantation, and urinary NGAL and IL-18 at 24 and 168 h correlated with the day 7 creatinine reduction ratio (CRR). Creatinine 148-158 interleukin 18 Homo sapiens 100-105 25071398-4 2014 In this study, we evaluated the associations between IL18 polymorphisms and graft function assessed by creatinine clearance in kidney transplant recipients. Creatinine 103-113 interleukin 18 Homo sapiens 53-57 25194409-7 2014 Interleukin-18 levels were not significantly different at the end of the study between the two groups, but it had a decreasing trend in the pioglitazone group (P = .002). Pioglitazone 140-152 interleukin 18 Homo sapiens 0-14 24842757-7 2014 IL-18RAP responded to NOD2-initiated early, caspase-1-dependent autocrine IL-18, which dramatically enhanced MAPK, NF-kappaB, PI3K, and calcium signaling. Calcium 136-143 interleukin 18 Homo sapiens 0-5 24431405-5 2014 Using in vitro models with mouse and human malignant mesothelioma cells, curcumin is shown to induce pyroptosis through activation of caspase-1 and increased release of high-mobility group box 1 (HMGB1) without processing of IL-1beta and IL-18. Curcumin 73-81 interleukin 18 Homo sapiens 238-243 24711695-3 2014 Pirfenidone is a multifunctional, orally available small molecule with anti-fibrotic, anti-inflammatory, and antioxidative activities, and has been shown to be a modulator of cytokines and growth factors, including TGF-beta1, TNF-alpha, bFGF, IFN-gamma, IL-1beta, and IL-18 in animal models. pirfenidone 0-11 interleukin 18 Homo sapiens 268-273 23820889-2 2014 IL-18 is produced and stored as an inactive precursor (proIL-18) in several cells including keratinocytes, and thus appropriate processing is required to release its active form. proil 55-60 interleukin 18 Homo sapiens 0-5 25004828-8 2014 CRH also up-regulates IL-18 expression by increasing intracellular reactive oxygen in microglia cells. Oxygen 76-82 interleukin 18 Homo sapiens 22-27 24599060-10 2014 The high IL-18 group had a worse LV systolic function as demonstrated by reduced GLS and CS. Glucosinolates 81-84 interleukin 18 Homo sapiens 9-14 24599060-10 2014 The high IL-18 group had a worse LV systolic function as demonstrated by reduced GLS and CS. Cesium 89-91 interleukin 18 Homo sapiens 9-14 24581851-5 2014 BQ123 (1mu M) and p38 MAPK siRNA and inhibitor PD169316 (25 muM) completely abolished the promoting effect of ET-1 on IL-18 expression. cyclo(Trp-Asp-Pro-Val-Leu) 0-5 interleukin 18 Homo sapiens 118-123 24581851-5 2014 BQ123 (1mu M) and p38 MAPK siRNA and inhibitor PD169316 (25 muM) completely abolished the promoting effect of ET-1 on IL-18 expression. 2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole 47-55 interleukin 18 Homo sapiens 118-123 24356959-5 2014 We find that hypersecretion of IL-1beta and IL-18 requires reactive oxygen species and is associated with an oxidized redox status of monocytes but not lymphocytes. Reactive Oxygen Species 59-82 interleukin 18 Homo sapiens 44-49 24861285-4 2014 An association between IL-18 gene promoter polymorphisms and pegylated interferon (PEG-IFN) and ribavirin treatment outcomes has been reported for individuals with chronic hepatitis C virus genotype 1 (HCV-1). Ribavirin 96-105 interleukin 18 Homo sapiens 23-28 25052265-8 2014 However, IL18 haplotypes (rs360719-rs187238-rs204355) TCT and CGT were associated with triglycerides <= 110 mg/dL and HDL < 40 mg/dL, respectively. Triglycerides 87-100 interleukin 18 Homo sapiens 9-13 24513871-12 2014 CONCLUSIONS: These findings provide new insight into the pathogenesis of MDD and the effects of amitriptyline treatment on NLRP3 inflammasome activation and IL-1beta and IL-18 serum levels. Amitriptyline 96-109 interleukin 18 Homo sapiens 170-175 24269698-3 2014 Previously, we have shown that water-damaged building associated trichothecene mycotoxins, including roridin A, trigger IL-1beta and IL-18 secretion in human macrophages. Water 31-36 interleukin 18 Homo sapiens 133-138 24275551-10 2014 Although leptin (and LPS) has a synergistic effect with exogenous ATP on IL-18 secretion in both THP-1 and primary monocytes, experiments involving ATP assays and pharmacological inhibition of ATP signalling failed to provide any evidence that endogenous ATP secreted by leptin-stimulated monocytes was responsible for enhancement of monocyte IL-18 secretion by leptin. Adenosine Triphosphate 66-69 interleukin 18 Homo sapiens 73-78 24275551-11 2014 Analysis of the action of caspase-1 revealed that leptin up regulates caspase-1 activity and the effect of leptin on IL-18 release is prevented by caspase-1 inhibitor (Ac-YVAD-cmk). ac-yvad 168-175 interleukin 18 Homo sapiens 117-122 24269698-3 2014 Previously, we have shown that water-damaged building associated trichothecene mycotoxins, including roridin A, trigger IL-1beta and IL-18 secretion in human macrophages. Trichothecenes 65-78 interleukin 18 Homo sapiens 133-138 24269698-3 2014 Previously, we have shown that water-damaged building associated trichothecene mycotoxins, including roridin A, trigger IL-1beta and IL-18 secretion in human macrophages. roridin A 101-110 interleukin 18 Homo sapiens 133-138 24269698-8 2014 In addition, gene silencing of c-Cbl, a negative autophagy-related regulator of c-Src, resulted in enhanced secretion of IL-1beta and IL-18 in response to trichothecene mycotoxin stimulation in human macrophages. trichothecene mycotoxin 155-178 interleukin 18 Homo sapiens 134-139 24079335-6 2013 Furthermore, rhRLX administration attenuated the increase in leucocyte activation, as suggested by inhibition of myeloperoxidase activity, intercellular-adhesion-molecule-1 expression, interleukin (IL)-1beta, IL-18 and tumour necrosis factor-alpha production as well as increase in IL-10 production. rhrlx 13-18 interleukin 18 Homo sapiens 209-214 24464597-11 2014 In standard multiple regression analysis, the atorvastatin-induced reduction in MMP-7 was independently associated with LDL and IL-18 downregulation (R(2)=0.648, p=0.017). Atorvastatin 46-58 interleukin 18 Homo sapiens 128-133 24349532-5 2013 However, among alcohol consumers, people with A/A homozygotes of IL-18 -607A/C polymorphism had a 2.38-fold (95% CI=1.17-4.86; p=0.01) increased risk of developing oral cancer compared with those with C/C homozygotes. Alcohols 15-22 interleukin 18 Homo sapiens 65-70 23454144-6 2013 ROS are also involved in the activation of the NLRP3/NALP3 inflammasome, which is required to direct the proteolytic maturation of inflammatory cytokines such as IL-1beta and IL-18, which are all integral to the process of dendritic cells mobilization, migration and functional maturation. Reactive Oxygen Species 0-3 interleukin 18 Homo sapiens 175-180 23872479-2 2013 Here we demonstrate for the first time that the proinflammatory cytokine interleukin (IL)-18 induces TRAF3IP2 expression in primary cardiac fibroblasts (CF) in a Nox4/hydrogen peroxide-dependent manner. Hydrogen Peroxide 167-184 interleukin 18 Homo sapiens 73-92 23872479-3 2013 Silencing TRAF3IP2 using a phosphorothioated, 2"-O-methyl modified, cholesterol-tagged TRAF3IP2 siRNA duplex markedly attenuated IL-18-induced NF-kappaB and AP-1 activation and CF migration. phosphorothioated 27-44 interleukin 18 Homo sapiens 129-134 23872479-3 2013 Silencing TRAF3IP2 using a phosphorothioated, 2"-O-methyl modified, cholesterol-tagged TRAF3IP2 siRNA duplex markedly attenuated IL-18-induced NF-kappaB and AP-1 activation and CF migration. 2"-o-methyl 46-57 interleukin 18 Homo sapiens 129-134 23872479-3 2013 Silencing TRAF3IP2 using a phosphorothioated, 2"-O-methyl modified, cholesterol-tagged TRAF3IP2 siRNA duplex markedly attenuated IL-18-induced NF-kappaB and AP-1 activation and CF migration. Cholesterol 68-79 interleukin 18 Homo sapiens 129-134 24040783-6 2013 At 24 hours after MRI with gadolinium administration in the Gd-CIN group, the urinary KIM-1, IL-18 and Cys-C were significantly increased. Gadolinium 27-37 interleukin 18 Homo sapiens 93-98 24040783-7 2013 Logistic regression analysis showed that urinary KIM-1 and IL-18 at 24 hours after gadolinium injection were independent predictive markers of Gd-CIN. Gadolinium 83-93 interleukin 18 Homo sapiens 59-64 23600826-6 2013 In contrast, IL-18 was up-regulated upon co-stimulation with fatty acids and uric acid. Fatty Acids 61-72 interleukin 18 Homo sapiens 13-18 23957020-7 2013 RESULTS: Levels of interleukin (IL)-1beta were significantly elevated in participants diagnosed with CTTH relative to healthy controls, while IL-18 levels were found to be significantly elevated in men with CTTH. ctth 207-211 interleukin 18 Homo sapiens 142-147 23706318-8 2013 IL-1beta, IL-10, IL-18 and TNF-alpha upregulated the expression of cardiac structural proteins and increased the ROS level in differentiating EBs. Reactive Oxygen Species 113-116 interleukin 18 Homo sapiens 17-22 23706318-9 2013 In addition, ROS scavenger reversed the cardiogenic effect of IL-10 and IL-18. Reactive Oxygen Species 13-16 interleukin 18 Homo sapiens 72-77 23706318-11 2013 IL-1beta, IL-10, IL-18 and TNF-alpha enhance cardiac differentiation and ROS may serve as the messenger in cardiogenic signaling from these cytokines. Reactive Oxygen Species 73-76 interleukin 18 Homo sapiens 17-22 23660216-8 2013 In patients with pleural exudates of all etiologies and in those with parapneumonic PEs/empyema, PF IL-18 levels were correlated with markers of acute pleural inflammation such as the percentage of PF neutrophils, PF LDH and PF/serum LDH ratio, low PF glucose and PF/serum glucose ratio and low PF pH. Glucose 252-259 interleukin 18 Homo sapiens 100-105 23660216-8 2013 In patients with pleural exudates of all etiologies and in those with parapneumonic PEs/empyema, PF IL-18 levels were correlated with markers of acute pleural inflammation such as the percentage of PF neutrophils, PF LDH and PF/serum LDH ratio, low PF glucose and PF/serum glucose ratio and low PF pH. Glucose 273-280 interleukin 18 Homo sapiens 100-105 23587914-10 2013 The results of our meta-analysis suggest that IL-18 rs360722 SNP is only associated with RA susceptibility. Radium 89-91 interleukin 18 Homo sapiens 46-51 23541442-4 2013 IL-18 induced Nox1-dependent ROS generation, TRAF3IP2 expression, and IKK/NF-kappaB and JNK/AP-1 activation. ros 29-32 interleukin 18 Homo sapiens 0-5 23541442-7 2013 Importantly, the HMG-coA reductase inhibitor simvastatin attenuated IL-18-induced TRAF3IP2 induction. Simvastatin 45-56 interleukin 18 Homo sapiens 68-73 23915129-11 2013 In vitro studies demonstrated that MitoQ decreases IL-1 beta and IL-18 production in human THP-1 cells. mitoquinone 35-40 interleukin 18 Homo sapiens 65-70 23794630-3 2013 IL-18 was shown to enhance zoledronate-induced gammadelta T cell activation. Zoledronic Acid 27-38 interleukin 18 Homo sapiens 0-5 23794630-5 2013 We report in this article that downstream depletion of geranylgeranyl pyrophosphate (GGPP), which is required for protein prenylation, caused cell stress in monocytes, followed by caspase-1-mediated maturation and release of IL-18, which, in turn, induced gammadelta T cell CCL2. geranylgeranyl pyrophosphate 55-83 interleukin 18 Homo sapiens 225-230 23794630-5 2013 We report in this article that downstream depletion of geranylgeranyl pyrophosphate (GGPP), which is required for protein prenylation, caused cell stress in monocytes, followed by caspase-1-mediated maturation and release of IL-18, which, in turn, induced gammadelta T cell CCL2. geranylgeranyl pyrophosphate 85-89 interleukin 18 Homo sapiens 225-230 23794630-7 2013 Moreover, repletion of GGPP, which prevented acute zoledronate toxicity, and supplementation with IL-18, which strongly upregulated IL-2Ralpha (CD25) and favored the central memory phenotype, were sufficient to enable zoledronate-induced expansion of highly purified gammadelta T cells, even when starting cell numbers were as low as 10(4) gammadelta T cells. Zoledronic Acid 218-229 interleukin 18 Homo sapiens 98-103 23425082-17 2013 CONCLUSIONS: Arterial ammonia, inflammatory mediators (TNF-alpha, IL-6, IL-18), and serum endotoxin reduce and MRS abnormalities improve after treatment with lactulose in patients with MHE. Lactulose 158-167 interleukin 18 Homo sapiens 72-77 23805108-11 2013 For H19 the difference was driven by a significant reduction in %5-mC among controls; for IL18 the difference was driven by both a reduction in %5-mC among controls and an increase in %5-mC among cases. 5-mc 145-149 interleukin 18 Homo sapiens 90-94 23805108-11 2013 For H19 the difference was driven by a significant reduction in %5-mC among controls; for IL18 the difference was driven by both a reduction in %5-mC among controls and an increase in %5-mC among cases. 5-mc 145-149 interleukin 18 Homo sapiens 90-94 23805108-14 2013 Additionally, pre-deployment the people who later became cases had lower levels of IL18 %5-mC compared with controls. 5-mc 89-93 interleukin 18 Homo sapiens 83-87 23600826-6 2013 In contrast, IL-18 was up-regulated upon co-stimulation with fatty acids and uric acid. Uric Acid 77-86 interleukin 18 Homo sapiens 13-18 23656401-0 2013 Type 1/type 2 cytokine serum levels and role of interleukin-18 in children with steroid-sensitive nephrotic syndrome. Steroids 80-87 interleukin 18 Homo sapiens 48-62 24049660-11 2013 The significantly increased postchallenge concentrations of IL-2, IL-8, IL-12p70, IL-13, IL-18, IFN- gamma , TNF- alpha , and TGF- beta were released by peripheral blood cells after stimulation with PMA, as compared with both their prechallenge concentrations and with the PBS control values. Tetradecanoylphorbol Acetate 199-202 interleukin 18 Homo sapiens 89-94 23434541-3 2013 Extracellular ATP can cause P2X receptors to activate the NOD-like receptor 3 (NLRP3) inflammasome and cause IL-1beta and IL-18 maturation and release. Adenosine Triphosphate 14-17 interleukin 18 Homo sapiens 122-127 23434541-8 2013 In vitro culture experiments showed NLRP3 protein expression, cleavage of caspase-1 and IL-1beta, and release of IL-1beta, IL-18 and ATP in HK-2 cells significantly increased after high glucose stimulation. Glucose 186-193 interleukin 18 Homo sapiens 123-128 22967010-3 2013 Aluminum adjuvants promote oxidative stress and increase inflammasome activity, leading to the release of IL-1beta, IL-18, and IL-33, but not the important regulatory cytokine IL-12. Aluminum 0-8 interleukin 18 Homo sapiens 116-121 23063874-8 2013 At not-cytotoxic concentrations (cell viability higher of 80%, as assessed by MTT reduction assay), all contact sensitizers, including pre-pro-haptens, induced a dose-related increase in IL-18, whereas both irritants, with the exception of sulfamic acid, and respiratory allergens failed. monooxyethylene trimethylolpropane tristearate 78-81 interleukin 18 Homo sapiens 187-192 23151944-0 2013 Zoledronic acid-induced expansion of gammadelta T cells from early-stage breast cancer patients: effect of IL-18 on helper NK cells. Zoledronic Acid 0-15 interleukin 18 Homo sapiens 107-112 23178856-6 2013 We proved that IL-18 increased the tyrosinase activity and melanin content in normal human foreskin-derived epidermal melanocytes (NHEM). Melanins 59-66 interleukin 18 Homo sapiens 15-20 22784440-4 2013 When administered simultaneously to 1x10(6)iDCs/ml, IL-18+PGE2 induced the secretion of 131.4+-6.7 pg IL-12/ml and 355+-87 pg IFN-gamma/ml but there was no detectable IL-10 secretion. Dinoprostone 58-62 interleukin 18 Homo sapiens 52-57 23835996-7 2013 BALF level of IL-18 was lower in the NSCLC than that in the HP group, but higher than that in the BBS patients. Hematoporphyrins 60-62 interleukin 18 Homo sapiens 14-19 23044094-5 2013 First, we identified suitable condition of UV-irradiation (3.5 J/cm(2)) by investigating the effect of UVA irradiation on intracellular IL-18 on untreated or chloropromazine (a representative phototoxic compound)-treated NCTC2544 cells. Chlorpromazine 158-173 interleukin 18 Homo sapiens 136-141 23335921-9 2012 Phagocytosis of aluminum adjuvants followed by disruption of the phagolysosome activates NLRP3-inflammasomes resulting in the release of active IL-1beta and IL-18. aluminum adjuvants 16-34 interleukin 18 Homo sapiens 157-162 23137633-9 2013 Furthermore, combined genotype analysis of IL-18 and IL-12B has pointed out that patients with CC/AA/AA genotype have the worst glucose control based on HbA1c (8.7%, range 6.8-13.1%). Glucose 128-135 interleukin 18 Homo sapiens 43-48 23186077-7 2012 After paricalcitol treatment, levels of the inflammatory markers CRP, TNF-alpha, IL-6 and IL-18 were significantly reduced in serum and the level of anti-inflammatory cytokine IL-10 was increased. paricalcitol 6-18 interleukin 18 Homo sapiens 90-95 22700183-6 2012 The superior part of the MHb strongly expressed interleukin-18 and was innervated by noradrenergic fibers. 2-((3'-METHYL-4'-HYDROXYPHENYL)AZO)BENZOIC ACID 25-28 interleukin 18 Homo sapiens 48-62 23840204-11 2013 There was a greater rise in NGAL and IL-18 after 3 h in the bicarbonates versus NaCl 0.9% group: 1115% versus 240% increase (P = 0.03) and 338% increase versus 1.4% decrease (P = 0.01). Bicarbonates 60-72 interleukin 18 Homo sapiens 37-42 23144495-0 2012 Cutting edge: FAS (CD95) mediates noncanonical IL-1beta and IL-18 maturation via caspase-8 in an RIP3-independent manner. ammonium ferrous sulfate 14-17 interleukin 18 Homo sapiens 60-65 23153702-7 2012 However, the treatment with both steroids decreased the secretion of TNF-alpha, IL-18 and TGF-beta1 by EEC in the presence of ESC. Steroids 33-41 interleukin 18 Homo sapiens 80-85 22688551-9 2012 Vildagliptin treatment was associated with a stronger decrease in nitrotyrosine (P < 0.01), IL-6 (P < 0.05), and IL-18 (P < 0.05) than sitagliptin treatment. Vildagliptin 0-12 interleukin 18 Homo sapiens 119-124 22825306-9 2012 Our results showed that IL-18 stimulated the COX-2 and TNF-alpha expressions in primary synoviocytes, while increasing PGE2 and TNF-alpha levels in the supernatant (P<0.05) of the culture medium in primary synoviocytes. Dinoprostone 119-123 interleukin 18 Homo sapiens 24-29 22825306-10 2012 IL-18 also induced high PGE2 level production in second-generation synoviocytes (P<0.05). Dinoprostone 24-28 interleukin 18 Homo sapiens 0-5 22825306-11 2012 Moreover, IL-18 upregulated COX-2 and TNF-alpha mRNA in chondrocytes, while promoting PGE2 and TNF-alpha (P<0.05) secretions in a dose-dependent manner. Dinoprostone 86-90 interleukin 18 Homo sapiens 10-15 23298491-6 2012 In this study we found that all cardiovascular patients (CABG and VR) have increased circulating IL-18 level compared to healthy control subjects (p &#60; 0.0001), but no statistical significant difference was observed between CABG and VR groups (p = 0.35). Adenosine Monophosphate 150-153 interleukin 18 Homo sapiens 97-102 23298491-7 2012 A great increase in the gene expression of IL-18 (p &#60; 0.05), IL-18 R1 (p &#60; 0.01) and IL-18 RAP (p &#60; 0.001) was observed in EAT samples obtained from CABG vs VR patients. Adenosine Monophosphate 53-56 interleukin 18 Homo sapiens 43-48 22050122-9 2012 EGCG also significantly downregulated rh-MIF-induced expression of Th-related cytokines and chemokines, such as interleukin (IL)-6, IL-18, transforming growth factor-beta, CCL17, CCL22 and CXCL10, in human keratinocytes. epigallocatechin gallate 0-4 interleukin 18 Homo sapiens 132-137 22433003-12 2012 Moreover, licofelone inhibited IL-18-induced proliferation of mesangial cells. licofelone 10-20 interleukin 18 Homo sapiens 31-36 22433003-13 2012 We conclude that licofelone inhibits interleukin-18-induced pro-inflammatory cytokine release and cellular proliferation in HMC, which may represent a really interesting therapeutic approach for glomerulonephritis in children. licofelone 17-27 interleukin 18 Homo sapiens 37-51 23293472-11 2012 Moreover, the IL-18 levels between cancer patients and controls with in of combined mode chewers smokers and alcohol (CSA), smokers with alcohol showed significant difference (P < 0.01) than controls. Alcohols 109-116 interleukin 18 Homo sapiens 14-19 23293472-11 2012 Moreover, the IL-18 levels between cancer patients and controls with in of combined mode chewers smokers and alcohol (CSA), smokers with alcohol showed significant difference (P < 0.01) than controls. Cyclosporine 118-121 interleukin 18 Homo sapiens 14-19 23293472-11 2012 Moreover, the IL-18 levels between cancer patients and controls with in of combined mode chewers smokers and alcohol (CSA), smokers with alcohol showed significant difference (P < 0.01) than controls. Alcohols 137-144 interleukin 18 Homo sapiens 14-19 22699929-9 2012 Anti asialo GM1 could reduce natural killer cell cytotoxicity, production of IFN-gamma, and regression of LLC tumor aroused by IL18-IL2. G(M1) Ganglioside 12-15 interleukin 18 Homo sapiens 127-135 22690919-0 2012 Upregulation of stromal cell-derived factor by IL-17 and IL-18 via a phosphatidylinositol 3-kinase-dependent pathway. Phosphatidylinositols 69-89 interleukin 18 Homo sapiens 57-62 22433003-0 2012 Licofelone inhibits interleukin-18-induced pro-inflammatory cytokine release and cellular proliferation in human mesangial cells. licofelone 0-10 interleukin 18 Homo sapiens 20-34 22433003-9 2012 It was found that licofelone attenuated interleukin-18-induced COX-2 enzyme activity in HMC and prostaglandin E2 release in a dose-dependent manner. licofelone 18-28 interleukin 18 Homo sapiens 40-54 22433003-9 2012 It was found that licofelone attenuated interleukin-18-induced COX-2 enzyme activity in HMC and prostaglandin E2 release in a dose-dependent manner. Dinoprostone 96-112 interleukin 18 Homo sapiens 40-54 22433003-10 2012 Similarly, licofelone inhibited interleukin-18-induced 5-LOX enzyme activity and leukotriene release. licofelone 11-21 interleukin 18 Homo sapiens 32-46 22433003-10 2012 Similarly, licofelone inhibited interleukin-18-induced 5-LOX enzyme activity and leukotriene release. Leukotrienes 81-92 interleukin 18 Homo sapiens 32-46 22433003-11 2012 Licofelone reduced interleukin-18-induced phosphorylation of p38 mitogen-activated protein kinase and suppressed monocyte chemotactic protein-1 and interferon-gamma synthesis. licofelone 0-10 interleukin 18 Homo sapiens 19-33 22226490-0 2012 Association of IL-18 genotype with impaired glucose regulation in Korean women with polycystic ovary syndrome. Glucose 44-51 interleukin 18 Homo sapiens 15-20 21615452-5 2012 The presence of IL-18 in human testicular cells was examined by immunohistochemical staining of paraffin-embedded sections, using a specific antibody for human IL-18. Paraffin 96-104 interleukin 18 Homo sapiens 16-21 21120501-0 2012 Correlation between serum concentrations of soluble Fas (CD95/Apo-1) and IL-18 in patients with systemic lupus erythematosus. ammonium ferrous sulfate 52-55 interleukin 18 Homo sapiens 73-78 23226309-5 2012 We also demonstrate that oenothein B enhanced the production of interferon-gamma (IFNgamma) by bovine and human NK cells alone and in combination with interleukin-18 (IL-18), a response not observed with other commonly studied polyphenols. oenothein B 25-36 interleukin 18 Homo sapiens 151-165 22498566-3 2012 METHODS AND RESULTS: IL-18 combined with IL-12 decreased ABCA1 expression and cellular cholesterol efflux in THP-1 macrophage-derived foam cells, whereas IL-18 or IL-12 alone had no effect. Cholesterol 87-98 interleukin 18 Homo sapiens 21-26 22498566-5 2012 IL-18R but not IL-12 receptor siRNA completely reversed the effects of IL-18 and IL-12 on ABCA1 expression and cellular cholesterol efflux. Cholesterol 120-131 interleukin 18 Homo sapiens 0-5 22498566-9 2012 CONCLUSIONS: IL-18 and IL-12 together can decrease ABCA1 expression and cellular cholesterol efflux in THP-1 macrophage-derived foam cells through the IL-18R/NF-kappaB signaling pathway. Cholesterol 81-92 interleukin 18 Homo sapiens 13-18 22008665-0 2012 The associations of IL-18 serum levels and promoter polymorphism with tacrolimus pharmacokinetics and hepatic allograft dysfunction in Chinese liver transplantation recipients. Tacrolimus 70-80 interleukin 18 Homo sapiens 20-25 22008665-9 2012 We found the recipients with higher IL-18 and IFN-gamma serum levels had lower tacrolimus concentration/dose (C/D) ratios (P<0.05). Tacrolimus 79-89 interleukin 18 Homo sapiens 36-41 22008665-12 2012 This study identifies IL-18 reduced tacrolimus concentration/dose (C/D) ratio through up regulation of P-glycoprotein (P-gp). Tacrolimus 36-46 interleukin 18 Homo sapiens 22-27 22799333-4 2012 HMGB1 was also found significantly enhanced the activity of ATP to induce IL-1beta and IL-18 by the induction of increased expression of pro-IL-1beta and pro-IL-18. Adenosine Triphosphate 60-63 interleukin 18 Homo sapiens 87-92 22799333-4 2012 HMGB1 was also found significantly enhanced the activity of ATP to induce IL-1beta and IL-18 by the induction of increased expression of pro-IL-1beta and pro-IL-18. Adenosine Triphosphate 60-63 interleukin 18 Homo sapiens 158-163 22423500-0 2012 A case of refractory adult-onset Still"s disease with high serum interleukin-18 levels treated with monitoring of serum levels of cyclosporine. Cyclosporine 130-142 interleukin 18 Homo sapiens 65-79 22423500-5 2012 The use of CsA accompanied by C2 and trough level monitoring should be considered for refractory AOSD patients with high levels of serum IL-18. Cyclosporine 11-14 interleukin 18 Homo sapiens 137-142 23226309-5 2012 We also demonstrate that oenothein B enhanced the production of interferon-gamma (IFNgamma) by bovine and human NK cells alone and in combination with interleukin-18 (IL-18), a response not observed with other commonly studied polyphenols. oenothein B 25-36 interleukin 18 Homo sapiens 167-172 22133036-4 2011 As little is known about the impact of MTX on other cytokines involved in the pathogenesis of RA, the present trial investigated the effect of MTX on IL-12A and IL-18 gene expression by peripheral blood mononuclear cells (PBMCs). Methotrexate 143-146 interleukin 18 Homo sapiens 161-166 22393394-7 2012 CONCLUSION/SIGNIFICANCE: Our results identify a mechanism mediated by Reactive Oxygen Species (ROS) production and potassium efflux as the two danger signals that link JEV infection to caspase-1 activation resulting in subsequent IL-1beta and IL-18 maturation. Reactive Oxygen Species 70-93 interleukin 18 Homo sapiens 243-248 22393394-7 2012 CONCLUSION/SIGNIFICANCE: Our results identify a mechanism mediated by Reactive Oxygen Species (ROS) production and potassium efflux as the two danger signals that link JEV infection to caspase-1 activation resulting in subsequent IL-1beta and IL-18 maturation. Reactive Oxygen Species 95-98 interleukin 18 Homo sapiens 243-248 22347372-7 2012 Alternaria extract (ALT-E) induced rapid release of IL-18, but not IL-4, IL-9, IL-13, IL-25, IL-33, or TSLP from cultured normal human bronchial epithelial cells; and in the BAL fluids of naive mice after challenge with ALT-E. alt-e 20-25 interleukin 18 Homo sapiens 52-57 22347372-9 2012 ALT-E induced much greater IL-18 release compared to 19 major outdoor allergens. alt-e 0-5 interleukin 18 Homo sapiens 27-32 22141572-6 2011 RESULTS: The +183 G-allele associated significantly with lower serum levels of IL-18 (p = 0.002, adjusted for age, glucose, body mass index and gender) and a 1.13- fold higher IL-18 gene-expression (p = 0.010). Glucose 115-122 interleukin 18 Homo sapiens 79-84 22141572-6 2011 RESULTS: The +183 G-allele associated significantly with lower serum levels of IL-18 (p = 0.002, adjusted for age, glucose, body mass index and gender) and a 1.13- fold higher IL-18 gene-expression (p = 0.010). Glucose 115-122 interleukin 18 Homo sapiens 176-181 22058415-0 2011 Uric acid-driven Th17 differentiation requires inflammasome-derived IL-1 and IL-18. Uric Acid 0-9 interleukin 18 Homo sapiens 77-82 22629344-3 2012 In addition, IL-15, IL-18, and IFN-beta secreted by poly I:C-treated macrophages are also involved in NKG2D expression and NK cell activation. Poly I-C 52-60 interleukin 18 Homo sapiens 20-25 22927815-4 2012 Previous structural and functional studies on IL18 and IL18BPs revealed an essential binding hot spot involving a lysine on IL18 and two aromatic residues on IL18BPs. Lysine 114-120 interleukin 18 Homo sapiens 46-50 22927815-4 2012 Previous structural and functional studies on IL18 and IL18BPs revealed an essential binding hot spot involving a lysine on IL18 and two aromatic residues on IL18BPs. Lysine 114-120 interleukin 18 Homo sapiens 55-59 22927815-7 2012 YLDV-IL18BP forms a disulfide bonded homo-dimer engaging IL18 in a 2:2 stoichiometry, in contrast to the 1:1 complex of ectromelia virus (ECTV) IL18BP and IL18. Disulfides 20-29 interleukin 18 Homo sapiens 5-9 22927815-9 2012 The overall architecture of the YLDV-IL18BP:IL18 complex is similar to that observed in the ECTV-IL18BP:IL18 complex, despite lacking the critical lysine-phenylalanine interaction. Lysine 147-153 interleukin 18 Homo sapiens 44-48 22927815-9 2012 The overall architecture of the YLDV-IL18BP:IL18 complex is similar to that observed in the ECTV-IL18BP:IL18 complex, despite lacking the critical lysine-phenylalanine interaction. Phenylalanine 154-167 interleukin 18 Homo sapiens 44-48 21835205-7 2011 PGE(2) alone showed slight effect on IL-1, IL-18, and IL-33 mRNA expression in DCs. Prostaglandins E 0-3 interleukin 18 Homo sapiens 43-48 21835205-8 2011 Of note, LPS combined with PGE(2) caused in a synergistic enhancement of mRNA expression of IL-33 but not IL-1 and IL-18. Prostaglandins E 27-30 interleukin 18 Homo sapiens 115-120 21681500-4 2011 We started steroid therapy in two cases with IL-18 values greater than 1000 pg/ml without being aware of IL-18 levels. Steroids 11-18 interleukin 18 Homo sapiens 45-50 21681500-7 2011 Patients with elevated levels of LDH are likely to have significantly elevated IL-18 values (>=1000 pg/ml) and thus can be candidates for steroid therapy. Steroids 141-148 interleukin 18 Homo sapiens 79-84 22133036-11 2011 Although the combination of MTX and corticosteroids significantly reduced the gene expression of IL-18, this key molecule was unaffected by MTX without corticosteroids. Methotrexate 28-31 interleukin 18 Homo sapiens 97-102 21719574-4 2011 Propolin D also significantly reduced the apoptosis of infected macrophage-like U937 cells and moderately reduced the secretion of interleukin (IL)-1beta and IL-18, which probably resulted from the inhibition of invasion plasmid antigen B secretion by this compound. nymphaeol B 0-10 interleukin 18 Homo sapiens 158-163 21692767-0 2011 A functional promoter polymorphism of the human IL18 gene is associated with aspirin-induced urticaria. Aspirin 77-84 interleukin 18 Homo sapiens 48-52 21692767-7 2011 RESULTS: A significant association was detected between both AIU in general and the aspirin-intolerant acute urticaria (AIAU) phenotype and the IL18 promoter polymorphism -607A/C. Aspirin 84-91 interleukin 18 Homo sapiens 144-148 21692767-11 2011 CONCLUSIONS: The high transcript haplotype ht1 [CG] of the IL18 gene may contribute to the development of acute cutaneous inflammation sensitive to aspirin, leading to the clinical presentation of AIAU. Aspirin 148-155 interleukin 18 Homo sapiens 59-63 21988719-2 2011 In macrophages and similar myeloid cells primed by lipopolysaccharide (LPS), activation of P2X7 by extracellular ATP opens a cation channel/pore allowing massive K+ efflux associated with processing and secretion of pro-inflammatory cytokines interleukin (IL)-1beta and IL-18. Adenosine Triphosphate 113-116 interleukin 18 Homo sapiens 270-275 21842238-0 2011 Adipose tissue expression of interleukin-18 mRNA is elevated in subjects with metabolic syndrome and independently associated with fasting glucose. Glucose 139-146 interleukin 18 Homo sapiens 29-43 21842238-9 2011 Multivariate analysis revealed fasting plasma glucose to be the only MetS component being independently associated with expression of IL-18 in AT (p < 0.05). Glucose 46-53 interleukin 18 Homo sapiens 134-139 21673342-5 2011 gammadelta T cell-independent NK cell activation in response to zoledronate was because of downstream depletion of endogenous prenyl pyrophosphates and subsequent caspase-1 activation in DC-like cells, which then provide mature IL-18 and IL-1beta for the activation of IL-2-primed NK cells. Zoledronic Acid 64-75 interleukin 18 Homo sapiens 228-233 21700474-5 2011 The current study demonstrated that rosiglitazone exerted a potent anti-inflammatory action via decreasing interleukin-18 (IL-18), tissue inhibitor of metalloproteinase-1 (TIMP-1), TLR4 and increasing PPARgamma in LPS-induced VSMCs. Rosiglitazone 36-49 interleukin 18 Homo sapiens 107-121 21719740-4 2011 The suppressed HBV replication by IL-18 could be rescued by the administration of BAY11-7082, an inhibitor of transcription factor NF-kappaB. 3-(4-methylphenylsulfonyl)-2-propenenitrile 82-92 interleukin 18 Homo sapiens 34-39 21575062-1 2011 BACKGROUND: We have previously reported that serum interleukin-18 (IL-18) concentration predicted the clinical outcome of patients with aggressive non-Hodgkin"s lymphoma treated with cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP). Cyclophosphamide 183-199 interleukin 18 Homo sapiens 51-65 21700474-5 2011 The current study demonstrated that rosiglitazone exerted a potent anti-inflammatory action via decreasing interleukin-18 (IL-18), tissue inhibitor of metalloproteinase-1 (TIMP-1), TLR4 and increasing PPARgamma in LPS-induced VSMCs. Rosiglitazone 36-49 interleukin 18 Homo sapiens 123-128 21575062-1 2011 BACKGROUND: We have previously reported that serum interleukin-18 (IL-18) concentration predicted the clinical outcome of patients with aggressive non-Hodgkin"s lymphoma treated with cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP). Cyclophosphamide 183-199 interleukin 18 Homo sapiens 67-72 21575062-1 2011 BACKGROUND: We have previously reported that serum interleukin-18 (IL-18) concentration predicted the clinical outcome of patients with aggressive non-Hodgkin"s lymphoma treated with cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP). Doxorubicin 201-212 interleukin 18 Homo sapiens 51-65 21575062-1 2011 BACKGROUND: We have previously reported that serum interleukin-18 (IL-18) concentration predicted the clinical outcome of patients with aggressive non-Hodgkin"s lymphoma treated with cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP). Doxorubicin 201-212 interleukin 18 Homo sapiens 67-72 21575062-1 2011 BACKGROUND: We have previously reported that serum interleukin-18 (IL-18) concentration predicted the clinical outcome of patients with aggressive non-Hodgkin"s lymphoma treated with cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP). Vincristine 214-225 interleukin 18 Homo sapiens 51-65 21575062-1 2011 BACKGROUND: We have previously reported that serum interleukin-18 (IL-18) concentration predicted the clinical outcome of patients with aggressive non-Hodgkin"s lymphoma treated with cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP). Vincristine 214-225 interleukin 18 Homo sapiens 67-72 21575062-1 2011 BACKGROUND: We have previously reported that serum interleukin-18 (IL-18) concentration predicted the clinical outcome of patients with aggressive non-Hodgkin"s lymphoma treated with cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP). Prednisolone 231-243 interleukin 18 Homo sapiens 51-65 21575062-1 2011 BACKGROUND: We have previously reported that serum interleukin-18 (IL-18) concentration predicted the clinical outcome of patients with aggressive non-Hodgkin"s lymphoma treated with cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP). Prednisolone 231-243 interleukin 18 Homo sapiens 67-72 21749729-2 2011 We report a 22-month-old girl with sJIA who developed severe MAS but was successfully treated with corticosteroids, cyclosporin A, and non-steroidal anti-inflammatory drugs by monitoring serum IL-18 levels. Cyclosporine 116-129 interleukin 18 Homo sapiens 193-198 21751146-7 2011 In contrast, granulomas and DFN contained mainly CD68+, CD163+/- and expressed more IL-17, IL-18, IL-23, CCL19, and CXCL11 than non-granulomatous cells. DFN 28-31 interleukin 18 Homo sapiens 91-96 21255134-9 2011 By contrast, there was an elevation in IL-18 level in the lower and higher ximelagatran dose groups after 6 months (P = 0.006 and P < 0.001, respectively). ximelagatran 75-87 interleukin 18 Homo sapiens 39-44 21646940-8 2011 We found that urine NGAL, KIM-1, Cys-C, and B2mG decreased with increasing GA. With correction for urine creatinine (cr), these markers and OPN/cr decreased with increasing GA. IL-18 (with or without correction for urine creatinine) did not differ across GA categories. Creatinine 221-231 interleukin 18 Homo sapiens 177-182 21481392-4 2011 RESULTS: IL-18 concentrations were strongly related to cigarette smoking, triglyceride, HDL-cholesterol (inversely) and to circulating levels of several inflammatory and haemostatic markers. Triglycerides 74-86 interleukin 18 Homo sapiens 9-14 21481392-4 2011 RESULTS: IL-18 concentrations were strongly related to cigarette smoking, triglyceride, HDL-cholesterol (inversely) and to circulating levels of several inflammatory and haemostatic markers. Cholesterol 92-103 interleukin 18 Homo sapiens 9-14 21611811-0 2011 IL-12- and IL-18-mediated, nitric oxide-induced apoptosis in TNF-alpha-mediated osteoclastogenesis of bone marrow cells. Nitric Oxide 27-39 interleukin 18 Homo sapiens 0-16 20227263-2 2011 More recently, a possible role for IL-18 in glucose and energy homeostasis has been suggested. Glucose 44-51 interleukin 18 Homo sapiens 35-40 21540068-8 2011 Mechanistic studies revealed that IFN-gamma production in response to MbetaCD plus IL-2 was IL-12 independent but depended on endogenous IL-18 and IL-1beta, and CD56(+)CD14(+) dendritic cell-like cells and B cells might mediate the ability of MbetaCD to activate NK cells. methyl-beta-cyclodextrin 70-77 interleukin 18 Homo sapiens 137-142 21572994-5 2011 The expression of IFN-gammainduced by IL-12 and IL-18 is sensitive to rapamycin and SB203580, indicating the possible involvement of mTOR and p38 MAP kinase, respectively, in this synergistic pathway. Sirolimus 70-79 interleukin 18 Homo sapiens 48-53 21456035-0 2011 Interleukin-18 upregulation is associated with the use of steroids in patients with ulcerative colitis. Steroids 58-66 interleukin 18 Homo sapiens 0-14 21572994-5 2011 The expression of IFN-gammainduced by IL-12 and IL-18 is sensitive to rapamycin and SB203580, indicating the possible involvement of mTOR and p38 MAP kinase, respectively, in this synergistic pathway. SB 203580 84-92 interleukin 18 Homo sapiens 48-53 21118329-2 2011 We carried out an extensive review of the literature pertaining to seizures in MS. We propose that an increase in interleukin-18, and its associated induction of indoleamine 2, 3-dioxygenase and quinolinic acid, mediates seizure activity in MS at least in part via an increase in interferon-gamma (IFNg). Quinolinic Acid 195-210 interleukin 18 Homo sapiens 114-128 21478880-3 2011 We show that the saturated fatty acid palmitate, but not unsaturated oleate, induces the activation of the NLRP3-ASC inflammasome, causing caspase-1, IL-1beta and IL-18 production. saturated fatty acid palmitate 17-47 interleukin 18 Homo sapiens 163-168 21118329-2 2011 We carried out an extensive review of the literature pertaining to seizures in MS. We propose that an increase in interleukin-18, and its associated induction of indoleamine 2, 3-dioxygenase and quinolinic acid, mediates seizure activity in MS at least in part via an increase in interferon-gamma (IFNg). indolamine 162-173 interleukin 18 Homo sapiens 114-128 21277902-9 2011 Furthermore, IL-18 significantly reduced L-kynurenine-induced down-regulation of NKG2D expression in NK cells. Kynurenine 41-53 interleukin 18 Homo sapiens 13-18 21266029-7 2011 In ten SC patients receiving therapy with risperidone, olanzapine or clozapine basal and LPS-induced production of RANTES and IL-18 was increased, while both basal and LPS-induced MCP-1 production was decreased. Risperidone 42-53 interleukin 18 Homo sapiens 126-131 21147091-4 2011 In this study, LPS treatment led to a marked upregulation of the levels of IL-1beta, IL-18, TNF-alpha, TGF-beta1, CCL2, CCL3, and CCL5 in HRMCs. hrmcs 138-143 interleukin 18 Homo sapiens 85-90 21239711-2 2011 We recently reported that IL-18 markedly amplified gammadelta T cell responses to zoledronate (ZOL)/IL-2. Zoledronic Acid 82-93 interleukin 18 Homo sapiens 26-31 21239711-2 2011 We recently reported that IL-18 markedly amplified gammadelta T cell responses to zoledronate (ZOL)/IL-2. Zoledronic Acid 95-98 interleukin 18 Homo sapiens 26-31 21042828-10 2011 In the CAM group, the changes of serum creatinine also showed a significant positive correlation with those of urinary ACR, urinary MCP-1, urinary IL-18 and serum levels of soluble ICAM-1. Creatinine 39-49 interleukin 18 Homo sapiens 147-152 21245324-3 2011 In this cohort of subjects with knee osteoarthritis (OA), synovial fluid uric acid was strongly correlated with synovial fluid IL-18 and IL-1beta. Uric Acid 73-82 interleukin 18 Homo sapiens 127-132 21245324-7 2011 The correlation of synovial fluid uric acid with the two cytokines (IL-18 and IL-1beta) known to be produced by uric acid-activated inflammasomes and the association of synovial fluid IL-18 with OA progression, lend strong support to the potential involvement of the innate immune system in OA pathology and OA progression. Uric Acid 34-43 interleukin 18 Homo sapiens 68-73 21245324-7 2011 The correlation of synovial fluid uric acid with the two cytokines (IL-18 and IL-1beta) known to be produced by uric acid-activated inflammasomes and the association of synovial fluid IL-18 with OA progression, lend strong support to the potential involvement of the innate immune system in OA pathology and OA progression. Uric Acid 112-121 interleukin 18 Homo sapiens 68-73 21398397-8 2011 CONCLUSION: Serum IL-10, IL-12, and IL-18 levels are predictive of the response to HCV treatment with pegylated interferon and ribavirin and are associated with amino acid substitutions in the ISDR and core region. Ribavirin 127-136 interleukin 18 Homo sapiens 36-41 21325476-10 2011 In particular, flavonoids typically found in citrus fruits were modestly associated with lower plasma IL-18 concentrations. Flavonoids 15-25 interleukin 18 Homo sapiens 102-107 21266029-7 2011 In ten SC patients receiving therapy with risperidone, olanzapine or clozapine basal and LPS-induced production of RANTES and IL-18 was increased, while both basal and LPS-induced MCP-1 production was decreased. Olanzapine 55-65 interleukin 18 Homo sapiens 126-131 21266029-7 2011 In ten SC patients receiving therapy with risperidone, olanzapine or clozapine basal and LPS-induced production of RANTES and IL-18 was increased, while both basal and LPS-induced MCP-1 production was decreased. Clozapine 69-78 interleukin 18 Homo sapiens 126-131 20940516-0 2011 Pitavastatin reduces elevated IL-18 levels in Japanese subjects with hypercholesterolemia: sub-analysis of Kansai investigation of statin for hyperlipidemic intervention in metabolism and endocrinology (KISHIMEN). pitavastatin 0-12 interleukin 18 Homo sapiens 30-35 21802664-3 2011 Our results show that the synthetic dsRNA polyinosinic-polycytidylic acid (poly I:C), a mimic of a common product of viral infections, activates NK cells directly in the context of cytokines found in the liver, i.e.: poly I:C plus inflammatory cytokines (IL-18, IL-12, and IL-2) induced NK cell IFN-gamma production and TRAIL expression, and anti-inflammatory cytokines (TGF-beta and IL-10) inhibit NK cell IFN-gamma production. Poly I-C 42-73 interleukin 18 Homo sapiens 255-260 21802664-3 2011 Our results show that the synthetic dsRNA polyinosinic-polycytidylic acid (poly I:C), a mimic of a common product of viral infections, activates NK cells directly in the context of cytokines found in the liver, i.e.: poly I:C plus inflammatory cytokines (IL-18, IL-12, and IL-2) induced NK cell IFN-gamma production and TRAIL expression, and anti-inflammatory cytokines (TGF-beta and IL-10) inhibit NK cell IFN-gamma production. Poly I-C 75-83 interleukin 18 Homo sapiens 255-260 20940516-2 2011 The aim of this study was to explore the effect of pitavastatin on serum levels of another inflammatory biomarker, interleukin-18 (IL-18), in a sub-analysis of the previous multi-center prospective study. pitavastatin 51-63 interleukin 18 Homo sapiens 115-129 20940516-2 2011 The aim of this study was to explore the effect of pitavastatin on serum levels of another inflammatory biomarker, interleukin-18 (IL-18), in a sub-analysis of the previous multi-center prospective study. pitavastatin 51-63 interleukin 18 Homo sapiens 131-136 20940516-9 2011 Pitavastatin did not significantly alter IL-18 levels in overall subjects, but reduced IL-18 levels in the highest quartile by 24.5% (median value) at 12 months. pitavastatin 0-12 interleukin 18 Homo sapiens 87-92 20940516-12 2011 CONCLUSION: Pitavastatin significantly improves lipid profiles, and reduces enhanced inflammation monitored by IL-18, as well as by hs-CRP, in hypercholesterolemic subjects. pitavastatin 12-24 interleukin 18 Homo sapiens 111-116 20730705-2 2010 We aimed to study if the changes observed in the insulin sensitivity of PCOS patients during treatment with oral contraceptives or metformin associate changes in the serum inflammatory markers interleukin-6 (IL-6) and interleukin-18 (IL-18). Metformin 131-140 interleukin 18 Homo sapiens 218-232 21931812-0 2011 Discovery of IL-18 as a novel secreted protein contributing to doxorubicin resistance by comparative secretome analysis of MCF-7 and MCF-7/Dox. Doxorubicin 63-74 interleukin 18 Homo sapiens 13-18 21931812-0 2011 Discovery of IL-18 as a novel secreted protein contributing to doxorubicin resistance by comparative secretome analysis of MCF-7 and MCF-7/Dox. Doxorubicin 139-142 interleukin 18 Homo sapiens 13-18 21931812-9 2011 Among them, the elevated expression of IL-18 in doxorubicin-resistant cell lines and breast tumor tissues was validated and its role in doxorubicin resistance was further confirmed by cell viability experiments in the presence or absence of this protein. Doxorubicin 48-59 interleukin 18 Homo sapiens 39-44 21931812-9 2011 Among them, the elevated expression of IL-18 in doxorubicin-resistant cell lines and breast tumor tissues was validated and its role in doxorubicin resistance was further confirmed by cell viability experiments in the presence or absence of this protein. Doxorubicin 136-147 interleukin 18 Homo sapiens 39-44 21931812-11 2011 IL-18 was further validated to contribute to doxorubicin resistance, in addition to its confirmed role in breast cancer metastasis. Doxorubicin 45-56 interleukin 18 Homo sapiens 0-5 20582713-5 2010 RESULTS: Treatment with 50 mmol/L glucose markedly increased the level of IL-1beta, IL-18, TNF-alpha, PGE2, NO, TGF-beta1, MCP-1, MIP-1alpha, and RANTES. Glucose 34-41 interleukin 18 Homo sapiens 84-89 20582713-6 2010 Honokiol (~20 mumol/L) treatment inhibited the HG-induced expression of inflammatory cytokines such as IL-1beta, IL-18, TNF-alpha, PGE2, NO, and TGF-beta1 in a dose-dependent manner. honokiol 0-8 interleukin 18 Homo sapiens 113-118 20977362-4 2010 RESULTS: When compared with control participants, levels of IL-18 and CXCL10 were higher in TB-IRIS case patients (P = .002 and .006, respectively), whereas CCL2 was lower (P = .006). Terbium 92-94 interleukin 18 Homo sapiens 60-65 20977362-6 2010 When TB-IRIS case patients were compared with ART-TB case patients, IL-18 was higher in ART-TB (P = .03), whereas CXCL10 was higher in TB-IRIS (P = .001). art 46-49 interleukin 18 Homo sapiens 68-73 20977362-6 2010 When TB-IRIS case patients were compared with ART-TB case patients, IL-18 was higher in ART-TB (P = .03), whereas CXCL10 was higher in TB-IRIS (P = .001). Terbium 5-7 interleukin 18 Homo sapiens 68-73 20977362-6 2010 When TB-IRIS case patients were compared with ART-TB case patients, IL-18 was higher in ART-TB (P = .03), whereas CXCL10 was higher in TB-IRIS (P = .001). Terbium 50-52 interleukin 18 Homo sapiens 68-73 21672342-0 2011 Interleukin-18 and IL18 -607A/C and -137G/C gene polymorphisms in patients with penicillin allergy. Penicillins 80-90 interleukin 18 Homo sapiens 19-23 21672342-1 2011 This study investigated the association between polymorphisms (-607A/C and -137G/C) in the promoter region of the IL18 gene (which encodes interleukin [IL]-18) and serum levels of IL-18, using standard genotyping techniques (sequence specific primer-polymerase chain reaction) and an enzyme-linked immunosorbent assay, respectively, in patients allergic to penicillin. Penicillins 357-367 interleukin 18 Homo sapiens 114-118 21672342-6 2011 In conclusion, IL18 -607A/C and -137G/C promoter polymorphisms are associated with susceptibility to penicillin allergy. Penicillins 101-111 interleukin 18 Homo sapiens 15-19 20844839-13 2011 These findings suggest that IL-18 delays neutrophil apoptosis following EtOH and burn injury by modulating the pro- and antiapoptotic proteins. Ethanol 72-76 interleukin 18 Homo sapiens 28-33 21915284-3 2011 It has recently been shown that an activator of the P2X7/inflammasome pathway, ATP, and the resultant products (IL-1beta/IL-18) are increased in COPD patients. Adenosine Triphosphate 79-82 interleukin 18 Homo sapiens 121-126 21915284-6 2011 We have demonstrated that CS-induced neutrophilia in a pre-clinical model is temporally associated with markers of inflammasome activation, (increased caspase 1 activity and release of IL-1beta/IL-18) in the lungs. Cesium 26-28 interleukin 18 Homo sapiens 194-199 20833691-7 2010 In adjusted analyses, only age, MMP-9, and IL-18 were independently associated with AF, in which IL-18 had the most significant association (P = 0.0011, standardized estimate &bgr = 1.76, OR = 1.02, 95% confidence interval: 1.01-1.03). Adenosine Monophosphate 176-179 interleukin 18 Homo sapiens 97-102 20613670-2 2010 The aim of this study was to investigate the effect of raloxifene, a selective estrogen receptor modulator, on serum M-CSF and IL-18 levels, cytokines that are presumably involved in the pathogenesis of atherosclerosis. Raloxifene Hydrochloride 55-65 interleukin 18 Homo sapiens 127-132 20613670-6 2010 RESULTS: Compared with the control group, the raloxifene group had a significant decrease in serum IL-18 concentrations and a 25.29% reduction in serum hs-CRP concentrations. Raloxifene Hydrochloride 46-56 interleukin 18 Homo sapiens 99-104 20613670-9 2010 CONCLUSIONS: Raloxifene reduces serum total cholesterol, low-density lipoprotein cholesterol, hs-CRP, and IL-18 levels. Raloxifene Hydrochloride 13-23 interleukin 18 Homo sapiens 106-111 20730705-2 2010 We aimed to study if the changes observed in the insulin sensitivity of PCOS patients during treatment with oral contraceptives or metformin associate changes in the serum inflammatory markers interleukin-6 (IL-6) and interleukin-18 (IL-18). Metformin 131-140 interleukin 18 Homo sapiens 234-239 20672973-7 2010 Morphine-dependent normal progressors and control macaques exhibited an increase in both IL-18 and IL-12, whereas IL-Ra levels remained constant throughout the observation period. Morphine 0-8 interleukin 18 Homo sapiens 89-94 20676966-4 2010 The results showed that lycopene and simvastatin applied together reduced TNFalpha and IFNgamma secretion, and abolished the increased production of the proinflammatory cytokine IL-1gamma caused by incubation with simvastatin only, an observation suggesting that simultaneous administration of both substances may reduce inflammatory responses. Lycopene 24-32 interleukin 18 Homo sapiens 178-187 20676966-4 2010 The results showed that lycopene and simvastatin applied together reduced TNFalpha and IFNgamma secretion, and abolished the increased production of the proinflammatory cytokine IL-1gamma caused by incubation with simvastatin only, an observation suggesting that simultaneous administration of both substances may reduce inflammatory responses. Simvastatin 37-48 interleukin 18 Homo sapiens 178-187 20676966-4 2010 The results showed that lycopene and simvastatin applied together reduced TNFalpha and IFNgamma secretion, and abolished the increased production of the proinflammatory cytokine IL-1gamma caused by incubation with simvastatin only, an observation suggesting that simultaneous administration of both substances may reduce inflammatory responses. Simvastatin 214-225 interleukin 18 Homo sapiens 178-187 20140691-2 2010 SYBR-green-dye-I-based real-time quantitative PCR method was used to compare the gene expression levels (indicated as 2(-DeltaDeltaCT) value) of IL-18 and IL-18BP in the peripheral blood leucocytes of LN patients and those in normal controls. sybr-green 0-10 interleukin 18 Homo sapiens 145-150 20421217-8 2010 In addition, MS-275 and SAHA suppressed lipopolysaccharide (LPS)-induced NF-kappaB p65 nuclear accumulation, IL-6, IL-18 and nitric oxide (NO) secretion as well as down-regulated pro-angiogenic VEGF and MMP-2 and MMP-9 production in E11 cells at sub-micromolar levels. entinostat 13-19 interleukin 18 Homo sapiens 115-120 20421217-8 2010 In addition, MS-275 and SAHA suppressed lipopolysaccharide (LPS)-induced NF-kappaB p65 nuclear accumulation, IL-6, IL-18 and nitric oxide (NO) secretion as well as down-regulated pro-angiogenic VEGF and MMP-2 and MMP-9 production in E11 cells at sub-micromolar levels. Vorinostat 24-28 interleukin 18 Homo sapiens 115-120 20476884-10 2010 When multiple regression analysis was performed, the extent of clinical AL > or =3 mm (P = 0.045) and > or =5 mm (P = 0.024) exhibited an association with IL-18, whereas CXCL16 was associated with clinical AL > or =5 mm (P = 0.040) and PD > or =7 mm (P = 0.047). al > 72-78 interleukin 18 Homo sapiens 161-166 20421217-9 2010 At similar concentrations, MS-275 and SAHA suppressed LPS-induced NF-kappaB p65 nuclear accumulation and IL-1beta, IL-6, IL-18 and TNF-alpha secretion in THP-1 monocytic cells. entinostat 27-33 interleukin 18 Homo sapiens 121-126 20421217-9 2010 At similar concentrations, MS-275 and SAHA suppressed LPS-induced NF-kappaB p65 nuclear accumulation and IL-1beta, IL-6, IL-18 and TNF-alpha secretion in THP-1 monocytic cells. Vorinostat 38-42 interleukin 18 Homo sapiens 121-126 21122335-6 2010 RESULTS: The expression levels of IL-2 and IL-18 at the onset of aGVHD were much higher than those after engraftment, being 2.69-fold and 3.12-fold increase, respectively (P = 0.000 & P = 0.000). Adenosine Monophosphate 183-186 interleukin 18 Homo sapiens 43-48 21122335-9 2010 Either IL-2 or IL-18 expression level could diagnose aGVHD as an independent factor (P = 0.000 & P = 0.000). Adenosine Monophosphate 96-99 interleukin 18 Homo sapiens 15-20 20140691-7 2010 It is noticeable that serum IL-18 levels in the patients treated with glucocorticoids and cyclophosphamide was lower than those treated with glucocorticoids only or glucocorticoids and other immune inhibitors such as chloroquine/hydroxychloroquine and azathioprine. Cyclophosphamide 90-106 interleukin 18 Homo sapiens 28-33 20140691-7 2010 It is noticeable that serum IL-18 levels in the patients treated with glucocorticoids and cyclophosphamide was lower than those treated with glucocorticoids only or glucocorticoids and other immune inhibitors such as chloroquine/hydroxychloroquine and azathioprine. Chloroquine 217-228 interleukin 18 Homo sapiens 28-33 20140691-7 2010 It is noticeable that serum IL-18 levels in the patients treated with glucocorticoids and cyclophosphamide was lower than those treated with glucocorticoids only or glucocorticoids and other immune inhibitors such as chloroquine/hydroxychloroquine and azathioprine. Hydroxychloroquine 229-247 interleukin 18 Homo sapiens 28-33 20140691-7 2010 It is noticeable that serum IL-18 levels in the patients treated with glucocorticoids and cyclophosphamide was lower than those treated with glucocorticoids only or glucocorticoids and other immune inhibitors such as chloroquine/hydroxychloroquine and azathioprine. Azathioprine 252-264 interleukin 18 Homo sapiens 28-33 20666265-0 2010 Effects of fluvastatin therapy on serum interleukin-18 and interleukin-10 levels in patients with acute coronary syndrome. Fluvastatin 11-22 interleukin 18 Homo sapiens 40-54 20666265-2 2010 Statins were shown to downregulate inflammatory cytokines.We conducted this study to investigate the effects of fluvastatin therapy on plasma interleukin-18 (IL-18) and interleukin-10 (IL-10) concentration in patients with acute coronary syndrome. Fluvastatin 112-123 interleukin 18 Homo sapiens 142-156 20666265-2 2010 Statins were shown to downregulate inflammatory cytokines.We conducted this study to investigate the effects of fluvastatin therapy on plasma interleukin-18 (IL-18) and interleukin-10 (IL-10) concentration in patients with acute coronary syndrome. Fluvastatin 112-123 interleukin 18 Homo sapiens 158-163 20004742-5 2010 While inhibition of the expression of the TNF-alpha gene was mediated predominantly by the alpha-bungarotoxin sensitive nAChRs, that of the IL-6 and IL-18 genes-by the mecamylamine-sensitive nAChRs. Mecamylamine 168-180 interleukin 18 Homo sapiens 149-154 20445349-0 2010 Effect of IL-18 on expansion of gammadelta T cells stimulated by zoledronate and IL-2. Zoledronic Acid 65-76 interleukin 18 Homo sapiens 10-15 20339966-2 2010 The aim of this study was to clarify whether ramipril was a therapeutic agent against monocyte chemoattractant protein 1 (MCP-1), interleukin 18 (IL-18), and interleukin 10 (IL-10) in elderly patients with ACS. Ramipril 45-53 interleukin 18 Homo sapiens 130-144 20339966-2 2010 The aim of this study was to clarify whether ramipril was a therapeutic agent against monocyte chemoattractant protein 1 (MCP-1), interleukin 18 (IL-18), and interleukin 10 (IL-10) in elderly patients with ACS. Ramipril 45-53 interleukin 18 Homo sapiens 146-151 20339966-6 2010 After treating with ramipril, the levels of MCP-1 and IL-18 were decreased in elderly patients with ACS. Ramipril 20-28 interleukin 18 Homo sapiens 54-59 20960175-0 2010 -607 C/A polymorphism in the promoter of IL-18 gene is associated with 2 h post-loading plasma glucose level in Chinese. Glucose 95-102 interleukin 18 Homo sapiens 41-46 20960175-1 2010 The purpose of this study is to find out whether the -607 C/A polymorphism in IL-18 gene promoter will affect serum IL-18 concentrations and glucose metabolism in Chinese subjects. Glucose 141-148 interleukin 18 Homo sapiens 78-83 20960175-7 2010 Multiple linear regression revealed that BMI (P < 0.0001) and 2 h-PPG (P = 0.019) were independently associated with IL-18 concentrations. h-ppg 67-72 interleukin 18 Homo sapiens 120-125 20960175-9 2010 Genotype A/A of IL-18 gene promoter -607 C/A polymorphism was associated with higher prevalence of type 2 diabetes and 2 h post-loading plasma glucose level. Glucose 143-150 interleukin 18 Homo sapiens 16-21 20684278-5 2010 RESULTS: IL-18-induced expressions of a-SMA mRNA and protein were inhibited obviously by a dose-dependent manner when HK-2 cells were incubated with SB203580 (0, 5, 10, 20 micromol/L) and IL-18 (100 ng/ml) for different time (P < 0.05). SB 203580 149-157 interleukin 18 Homo sapiens 9-14 20684278-5 2010 RESULTS: IL-18-induced expressions of a-SMA mRNA and protein were inhibited obviously by a dose-dependent manner when HK-2 cells were incubated with SB203580 (0, 5, 10, 20 micromol/L) and IL-18 (100 ng/ml) for different time (P < 0.05). SB 203580 149-157 interleukin 18 Homo sapiens 188-193 20086201-6 2010 In the DIO and DEX groups, circulating levels of MCP-1, MIP-1alpha, IL-15, and IL-18 were decreased, and adiponectin was increased (P < 0.05 for all). 3,3'-Dioctadecyloxacarbocyanine perchlorate 7-10 interleukin 18 Homo sapiens 79-84 20086201-6 2010 In the DIO and DEX groups, circulating levels of MCP-1, MIP-1alpha, IL-15, and IL-18 were decreased, and adiponectin was increased (P < 0.05 for all). Dextromethorphan 15-18 interleukin 18 Homo sapiens 79-84 20423837-6 2010 CONCLUSION: IL-18 may induce the production of PGE2, and their interactions they may play an important role in the pathogenesis of OA. Dinoprostone 47-51 interleukin 18 Homo sapiens 12-17 20199352-2 2010 We have investigated if IL-6 and IL-18 levels were related to coenzyme Q(10) (CoQ(10)), an antioxidant and a marker of oxidative stress in the plasma from normotensive and preeclamptic pregnancies. coq 78-81 interleukin 18 Homo sapiens 33-38 20199352-8 2010 However, in PE, IL-18 level was positively correlated with the reduced form of CoQ(10) (r = 0.3680, p = 0.0495). coq 79-82 interleukin 18 Homo sapiens 16-21 20199352-9 2010 CONCLUSION: This is the first demonstration that IL-18 is potentially linked to oxidative stress in PE, since its level correlates with the concentration of the powerful antioxidant CoQ(10). coq 182-185 interleukin 18 Homo sapiens 49-54 20065062-3 2010 Daptomycin led to lower CSF concentrations of interleukin 1beta (IL-1beta), IL-10, IL-18, monocyte chemoattractant protein 1 (MCP-1), and macrophage inflammatory protein 1 alpha (MIP-1alpha) (P < 0.05). Daptomycin 0-10 interleukin 18 Homo sapiens 83-88 19582378-6 2010 Our results showed that nail selenium was negatively associated with IL-18; nail zinc concentrations were inversely related to circulating IL-6, IL-18, and TNF-alpha, whereas nail copper (Cu) and Cu/selenium values were negatively correlated with homocysteine levels and the Cu/zinc ratio was unaffected. Selenium 29-37 interleukin 18 Homo sapiens 69-74 20004742-5 2010 While inhibition of the expression of the TNF-alpha gene was mediated predominantly by the alpha-bungarotoxin sensitive nAChRs, that of the IL-6 and IL-18 genes-by the mecamylamine-sensitive nAChRs. nachrs 191-197 interleukin 18 Homo sapiens 149-154 20026745-3 2010 The aim of this project was to compare IL-8 and IL-18 for their relative stability, activity, and interaction with GAGs, including chondroitin sulfate, hyaluronic acid, and heparan sulfate, present in high quantities in the lungs of patients with CF. Chondroitin Sulfates 131-150 interleukin 18 Homo sapiens 48-53 19865096-8 2010 Furthermore, we showed that IL-18 induced phosphorylation of extracellular signal-regulated kinase (ERK) within 10 minutes and that the ERK inhibitor PD98059 blocked the inhibitory effect of IL-18. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 150-157 interleukin 18 Homo sapiens 28-33 19865096-8 2010 Furthermore, we showed that IL-18 induced phosphorylation of extracellular signal-regulated kinase (ERK) within 10 minutes and that the ERK inhibitor PD98059 blocked the inhibitory effect of IL-18. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 150-157 interleukin 18 Homo sapiens 191-196 20383942-3 2010 In the present study, we found that bicyclol pre-treatment could attenuate the production of the inflammatory cytokines (TNF-alpha and IL-18) and chemokines (MCP-1, MIP-1 alpha and Rantes) and inhibit the activation of the p65-NF-kappaB and MAPK signaling pathways in CpG-ODN 2006-stimulated L02 hepatocytes in a dose-dependent manner. bicyclol 36-44 interleukin 18 Homo sapiens 135-140 19875365-6 2010 Receiver operator characteristic (ROC) curves for hs-CRP, IL-18, TNFalpha and WBC count, which displayed the capability of prediction about TCFA, showed the area under the curves were 0.95, 0.86, 0.79 and 0.70 (p<0.05), respectively. tcfa 140-144 interleukin 18 Homo sapiens 58-63 20060272-7 2010 We showed that the rs438421 polymorphism in the IL-12RB1 (TT) gene and the rs2066446 polymorphism in the IL-12RB2 (AA) gene had a significant interaction to develop the ADe phenotype (allergic type of AD), and those individuals with the risk alleles, TT/AA/CC (IL-12RB1/IL-12RB2/IL-18), have more than a 10-fold increased risk to develop ADe. Adenine 169-172 interleukin 18 Homo sapiens 279-284 20060272-9 2010 In addition to the IL-12R interaction, we suggest that the IL-18 gene can significantly interact with the IL-12R gene to develop ADe. Adenine 129-132 interleukin 18 Homo sapiens 59-64 19758343-0 2010 Serum levels of IL-18 and sIL-2R in patients with alopecia areata receiving combined therapy with oral cyclosporine and steroids. Cyclosporine 103-115 interleukin 18 Homo sapiens 16-21 19758343-0 2010 Serum levels of IL-18 and sIL-2R in patients with alopecia areata receiving combined therapy with oral cyclosporine and steroids. Steroids 120-128 interleukin 18 Homo sapiens 16-21 20026745-3 2010 The aim of this project was to compare IL-8 and IL-18 for their relative stability, activity, and interaction with GAGs, including chondroitin sulfate, hyaluronic acid, and heparan sulfate, present in high quantities in the lungs of patients with CF. Hyaluronic Acid 152-167 interleukin 18 Homo sapiens 48-53 20026745-3 2010 The aim of this project was to compare IL-8 and IL-18 for their relative stability, activity, and interaction with GAGs, including chondroitin sulfate, hyaluronic acid, and heparan sulfate, present in high quantities in the lungs of patients with CF. Heparitin Sulfate 173-188 interleukin 18 Homo sapiens 48-53 20028206-0 2010 Differentiation of human SH-SY5Y neuroblastoma cells by all-trans retinoic acid activates the interleukin-18 system. Tretinoin 66-79 interleukin 18 Homo sapiens 94-108 20028206-4 2010 Herein, we examined the effect of ATRA on the activity of the interleukin-18 (IL-18) system in human SH-SY5Y neuroblastoma cells. Tretinoin 34-38 interleukin 18 Homo sapiens 62-76 20028206-4 2010 Herein, we examined the effect of ATRA on the activity of the interleukin-18 (IL-18) system in human SH-SY5Y neuroblastoma cells. Tretinoin 34-38 interleukin 18 Homo sapiens 78-83 20028206-8 2010 Thereby, we identified the IL-18 system as a novel target of ATRA in neuroblastoma cells that might contribute to the therapeutic properties of retinoids in treatment of neuroblastoma. Retinoids 144-153 interleukin 18 Homo sapiens 27-32 20017708-0 2010 Association of interleukin-18 gene polymorphisms with calcium oxalate kidney stone disease. Calcium Oxalate 54-69 interleukin 18 Homo sapiens 15-29 19853308-6 2009 The expansion of gammadelta T cells, stimulated by zoledronate and IL-2, was strongly promoted by exogenous IL-18 and was inhibited by neutralizing anti-IL-18 receptor antibody. Zoledronic Acid 51-62 interleukin 18 Homo sapiens 108-113 22084597-2 2010 It is proposed that stress induced interleukin-18 (IL-18), via interferon-gamma (IFNy) and independently, increases indoleamine 2,3-dioxygenase (IDO) and subsequent quinolinic acid (QA) in microglia. Quinolinic Acid 165-180 interleukin 18 Homo sapiens 35-49 22084597-2 2010 It is proposed that stress induced interleukin-18 (IL-18), via interferon-gamma (IFNy) and independently, increases indoleamine 2,3-dioxygenase (IDO) and subsequent quinolinic acid (QA) in microglia. Quinolinic Acid 165-180 interleukin 18 Homo sapiens 51-56 22084597-2 2010 It is proposed that stress induced interleukin-18 (IL-18), via interferon-gamma (IFNy) and independently, increases indoleamine 2,3-dioxygenase (IDO) and subsequent quinolinic acid (QA) in microglia. Quinolinic Acid 182-184 interleukin 18 Homo sapiens 35-49 22084597-2 2010 It is proposed that stress induced interleukin-18 (IL-18), via interferon-gamma (IFNy) and independently, increases indoleamine 2,3-dioxygenase (IDO) and subsequent quinolinic acid (QA) in microglia. Quinolinic Acid 182-184 interleukin 18 Homo sapiens 51-56 19265174-0 2009 Role of proinflammatory cytokines IL-18 and IL-1beta in bleomycin-induced lung injury in humans and mice. Bleomycin 56-65 interleukin 18 Homo sapiens 34-39 20664297-9 2010 IL-18 mRNA and protein expression were significantly upregulated by AngII (p < 0.05) and LPS (p < 0.01), but not PDGF-BB, in primary MCs and a MC line (MES13). mes13 158-163 interleukin 18 Homo sapiens 0-5 19853308-6 2009 The expansion of gammadelta T cells, stimulated by zoledronate and IL-2, was strongly promoted by exogenous IL-18 and was inhibited by neutralizing anti-IL-18 receptor antibody. Zoledronic Acid 51-62 interleukin 18 Homo sapiens 153-158 19900154-5 2009 METHODS: We investigated the effect of 12 weeks of intervention with exercise, pravastatin, or both on serum levels of IL-18 in 34 subjects with the metabolic syndrome. Pravastatin 79-90 interleukin 18 Homo sapiens 119-124 19900154-6 2009 RESULTS: Levels of IL-18 were reduced by exercise (P = 0.036), pravastatin (P = 0.036), and the combination (P = 0.017) versus baseline, however without intergroup differences. Pravastatin 63-74 interleukin 18 Homo sapiens 19-24 19797730-1 2009 To evaluate the effects of high-dose dexamethasone (HD-DXM) on the balance of interleukin-18 (IL-18) and its endogenous antagonist IL-18 binding protein (IL-18BP) in ITP patients, IL-18, IL-18BP as well as IFN-gamma, IL-4 plasma levels and platelet counts were determined in 17 ITP patients receiving DXM 40 mg/day for four consecutive days and in 24 healthy subjects. Dexamethasone 55-58 interleukin 18 Homo sapiens 131-136 19265174-5 2009 Enhanced expression of both IL-18 and IL-18Ralpha was observed in the lungs of all five patients with bleomycin-induced lung injury. Bleomycin 102-111 interleukin 18 Homo sapiens 28-33 19797730-0 2009 High-dose dexamethasone regulates interleukin-18 and interleukin-18 binding protein in idiopathic thrombocytopenic purpura. Dexamethasone 10-23 interleukin 18 Homo sapiens 34-48 19797730-3 2009 The in vitro effects of DXM on IL-18BP and IL-18 of peripheral blood mononuclear cells (PBMCs) were studied by ELISA. Dexamethasone 24-27 interleukin 18 Homo sapiens 31-36 19797730-1 2009 To evaluate the effects of high-dose dexamethasone (HD-DXM) on the balance of interleukin-18 (IL-18) and its endogenous antagonist IL-18 binding protein (IL-18BP) in ITP patients, IL-18, IL-18BP as well as IFN-gamma, IL-4 plasma levels and platelet counts were determined in 17 ITP patients receiving DXM 40 mg/day for four consecutive days and in 24 healthy subjects. Dexamethasone 37-50 interleukin 18 Homo sapiens 78-92 19797730-1 2009 To evaluate the effects of high-dose dexamethasone (HD-DXM) on the balance of interleukin-18 (IL-18) and its endogenous antagonist IL-18 binding protein (IL-18BP) in ITP patients, IL-18, IL-18BP as well as IFN-gamma, IL-4 plasma levels and platelet counts were determined in 17 ITP patients receiving DXM 40 mg/day for four consecutive days and in 24 healthy subjects. Dexamethasone 37-50 interleukin 18 Homo sapiens 94-99 19797730-4 2009 HD-DXM administration increased IL-18BP and reduced IL-18 expression significantly (p<0.05), which resulted in a downregulation of IL-18/IL-18BP ratio p<0.05). Dexamethasone 3-6 interleukin 18 Homo sapiens 32-37 19797730-1 2009 To evaluate the effects of high-dose dexamethasone (HD-DXM) on the balance of interleukin-18 (IL-18) and its endogenous antagonist IL-18 binding protein (IL-18BP) in ITP patients, IL-18, IL-18BP as well as IFN-gamma, IL-4 plasma levels and platelet counts were determined in 17 ITP patients receiving DXM 40 mg/day for four consecutive days and in 24 healthy subjects. Dexamethasone 55-58 interleukin 18 Homo sapiens 78-92 19797730-1 2009 To evaluate the effects of high-dose dexamethasone (HD-DXM) on the balance of interleukin-18 (IL-18) and its endogenous antagonist IL-18 binding protein (IL-18BP) in ITP patients, IL-18, IL-18BP as well as IFN-gamma, IL-4 plasma levels and platelet counts were determined in 17 ITP patients receiving DXM 40 mg/day for four consecutive days and in 24 healthy subjects. Dexamethasone 55-58 interleukin 18 Homo sapiens 94-99 19797730-4 2009 HD-DXM administration increased IL-18BP and reduced IL-18 expression significantly (p<0.05), which resulted in a downregulation of IL-18/IL-18BP ratio p<0.05). Dexamethasone 3-6 interleukin 18 Homo sapiens 52-57 19797730-5 2009 In vitro, DXM had a significant effect on secretion of IL-18BP while diminishing IL-18 release from cultures of PBMCs. Dexamethasone 10-13 interleukin 18 Homo sapiens 55-60 19797730-6 2009 These results suggest that downregulation of IL-18/IL-18BP might account for its clinical efficacy of HD-DXM in active ITP. Dexamethasone 105-108 interleukin 18 Homo sapiens 45-50 19797730-6 2009 These results suggest that downregulation of IL-18/IL-18BP might account for its clinical efficacy of HD-DXM in active ITP. Inosine Triphosphate 119-122 interleukin 18 Homo sapiens 45-50 19825518-6 2009 In this review, we discuss recent reports demonstrating that in vitro inhibition of the mevalonate pathway by statins specifically increases the production, by activated monocytes, of cytokines of the IL-1 family, by enhancing caspase-1 activity, the enzyme responsible for IL-1beta and IL-18 maturation. Mevalonic Acid 88-98 interleukin 18 Homo sapiens 287-292 19595382-0 2009 Serum levels of interleukin-18 are reduced by diet and n-3 fatty acid intervention in elderly high-risk men. Fatty Acids, Omega-3 55-69 interleukin 18 Homo sapiens 16-30 19595382-7 2009 Changes in IL-18 were significantly correlated to changes in triglycerides (r = 0.20, P < .001), eicosapentaenoic acid (r = -0.14, P = .030), docosahexaenoic acid (r = -0.14, P = .034), body mass index (r = 0.16, P < .001), and waist circumference (r = 0.12, P = .007). Triglycerides 61-74 interleukin 18 Homo sapiens 11-16 19595382-7 2009 Changes in IL-18 were significantly correlated to changes in triglycerides (r = 0.20, P < .001), eicosapentaenoic acid (r = -0.14, P = .030), docosahexaenoic acid (r = -0.14, P = .034), body mass index (r = 0.16, P < .001), and waist circumference (r = 0.12, P = .007). Eicosapentaenoic Acid 100-121 interleukin 18 Homo sapiens 11-16 19595382-7 2009 Changes in IL-18 were significantly correlated to changes in triglycerides (r = 0.20, P < .001), eicosapentaenoic acid (r = -0.14, P = .030), docosahexaenoic acid (r = -0.14, P = .034), body mass index (r = 0.16, P < .001), and waist circumference (r = 0.12, P = .007). Docosahexaenoic Acids 145-165 interleukin 18 Homo sapiens 11-16 19748989-2 2009 Accruing evidence suggests that extracellular ATP participates in the inflammatory response as a proinflammatory mediator by activating the inflammasome complex, inducing secretion of cytokines (IL-1, IL-18) and cell damaging agents such as oxygen radicals, cationic proteins, and metalloproteases. Adenosine Triphosphate 46-49 interleukin 18 Homo sapiens 201-206 19816189-8 2009 Gemcitabine with 5-fluorouracil or oxaliplatin, but not alone, increased IL-18 and free IL-18 levels statistically significantly, without affecting IL-18BPa. gemcitabine 0-11 interleukin 18 Homo sapiens 73-78 19816189-8 2009 Gemcitabine with 5-fluorouracil or oxaliplatin, but not alone, increased IL-18 and free IL-18 levels statistically significantly, without affecting IL-18BPa. gemcitabine 0-11 interleukin 18 Homo sapiens 88-93 19816189-8 2009 Gemcitabine with 5-fluorouracil or oxaliplatin, but not alone, increased IL-18 and free IL-18 levels statistically significantly, without affecting IL-18BPa. Fluorouracil 17-31 interleukin 18 Homo sapiens 73-78 19816189-8 2009 Gemcitabine with 5-fluorouracil or oxaliplatin, but not alone, increased IL-18 and free IL-18 levels statistically significantly, without affecting IL-18BPa. Fluorouracil 17-31 interleukin 18 Homo sapiens 88-93 19816189-8 2009 Gemcitabine with 5-fluorouracil or oxaliplatin, but not alone, increased IL-18 and free IL-18 levels statistically significantly, without affecting IL-18BPa. Oxaliplatin 35-46 interleukin 18 Homo sapiens 73-78 19816189-8 2009 Gemcitabine with 5-fluorouracil or oxaliplatin, but not alone, increased IL-18 and free IL-18 levels statistically significantly, without affecting IL-18BPa. Oxaliplatin 35-46 interleukin 18 Homo sapiens 88-93 19553661-0 2009 Unusual water-mediated antigenic recognition of the proinflammatory cytokine interleukin-18. Water 8-13 interleukin 18 Homo sapiens 77-91 19553661-2 2009 Several anti-IL-18 agents are in clinical development, including the recombinant human antibody ABT-325, which is entering trials for autoimmune diseases. abt-325 96-103 interleukin 18 Homo sapiens 13-18 19553661-4 2009 Here we report three crystal structures: the murine antibody 125-2H Fab fragment bound to human IL-18, at 1.5 A resolution; the 125-2H Fab (2.3 A); and the ABT-325 Fab (1.5 A). Deuterium 65-67 interleukin 18 Homo sapiens 96-101 19553661-12 2009 Second, ABT-325 and 125-2H differ significantly in combining site character and architecture, thus explaining their ability to bind IL-18 simultaneously at distinct epitopes. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid 8-11 interleukin 18 Homo sapiens 132-137 19553661-12 2009 Second, ABT-325 and 125-2H differ significantly in combining site character and architecture, thus explaining their ability to bind IL-18 simultaneously at distinct epitopes. Deuterium 24-26 interleukin 18 Homo sapiens 132-137 19553661-14 2009 Third, given the high 125-2H potency, 10 well ordered water molecules are trapped upon complex formation in a cavity between two IL-18 loops and all six 125-2H complementarity-determining regions. Deuterium 26-28 interleukin 18 Homo sapiens 129-134 19553661-14 2009 Third, given the high 125-2H potency, 10 well ordered water molecules are trapped upon complex formation in a cavity between two IL-18 loops and all six 125-2H complementarity-determining regions. Water 54-59 interleukin 18 Homo sapiens 129-134 19553661-14 2009 Third, given the high 125-2H potency, 10 well ordered water molecules are trapped upon complex formation in a cavity between two IL-18 loops and all six 125-2H complementarity-determining regions. Deuterium 157-159 interleukin 18 Homo sapiens 129-134 19825520-7 2009 RESULTS: Pharmacological inhibition of the mevalonate pathway specifically enhanced the release of IL-1alpha, IL-1beta and IL-18 and inhibited IL-1ra production by LPS-activated PBMCs and THP-1 cells. Mevalonic Acid 43-53 interleukin 18 Homo sapiens 123-128 19825520-8 2009 Simvastatin did not modify pro-IL-1beta expression, but enhanced caspase-1 activity, the enzyme responsible for IL-1beta and IL-18 maturation. Simvastatin 0-11 interleukin 18 Homo sapiens 125-130 19825520-11 2009 CONCLUSION: Pharmacological inhibition of the mevalonate pathway by statins highlighted the specific induction of the proinflammatory cytokines of the IL-1 family whose maturation is either directly (i.e. IL-1beta and IL-18), or indirectly (i.e. IL-1alpha) dependant on caspase-1. Mevalonic Acid 46-56 interleukin 18 Homo sapiens 218-223 19605669-6 2009 Two patients receiving intravenous methylprednisolone therapy (1.0 g/day for 3 days) showed profound decreases in serum IL-18 levels after therapy. Methylprednisolone 35-53 interleukin 18 Homo sapiens 120-125 19609788-6 2009 The MC at concentrations of 10 and 1 microM, without toxicity to PBMC in 24 h, showed obvious inhibitory activity on IL-18 secretion. Methylcholanthrene 4-6 interleukin 18 Homo sapiens 117-122 19561311-0 2009 Resveratrol blocks interleukin-18-EMMPRIN cross-regulation and smooth muscle cell migration. Resveratrol 0-11 interleukin 18 Homo sapiens 19-33 19561311-6 2009 Resveratrol, via its antioxidant and anti-inflammatory properties, has the potential to inhibit the progression of atherosclerosis by blocking IL-18 and EMMPRIN cross-regulation and SMC migration. Resveratrol 0-11 interleukin 18 Homo sapiens 143-148 19581111-4 2009 IL-18 was moderately associated with HDL cholesterol r=-0.22, triglycerides r=0.16, and BMI r=0.14 (p for all < or =0.003) in the control population, but not among cases. Cholesterol 41-52 interleukin 18 Homo sapiens 0-5 19581111-4 2009 IL-18 was moderately associated with HDL cholesterol r=-0.22, triglycerides r=0.16, and BMI r=0.14 (p for all < or =0.003) in the control population, but not among cases. Triglycerides 62-75 interleukin 18 Homo sapiens 0-5 19596994-3 2009 We identify 7-bromoindirubin-3"-oxime, an indirubin oxime derivative that induces necrosis, as a potent inducer of caspase-1 activation and release of mature IL-1beta and IL-18. 7-bromoindirubin-3'-oxime 12-37 interleukin 18 Homo sapiens 171-176 19596994-3 2009 We identify 7-bromoindirubin-3"-oxime, an indirubin oxime derivative that induces necrosis, as a potent inducer of caspase-1 activation and release of mature IL-1beta and IL-18. indirubin oxime 42-57 interleukin 18 Homo sapiens 171-176 19609788-0 2009 An isomeric mixture of novel cerebrosides isolated from Impatiens pritzellii reduces lipopolysaccharide-induced release of IL-18 from human peripheral blood mononuclear cells. Cerebrosides 29-41 interleukin 18 Homo sapiens 123-128 19487269-3 2009 RESULTS: Golimumab + MTX treatment significantly decreased serum CRP, SAA, IL-18, E-selectin, TIMP-1, and MMP-9 levels (median percent changes of -4.1% to -74.3% across treatment groups) versus MTX alone (-5.8% to 9.7%) when first measured at Week 4; decreases were sustained through Week 16. Methotrexate 21-24 interleukin 18 Homo sapiens 75-80 19737478-0 2009 [Inhibitory effect of triptolide on interleukin-18 and its receptor in rheumatoid arthritis synovial fibroblasts]. triptolide 22-32 interleukin 18 Homo sapiens 36-50 19737478-1 2009 AIM: To determine the effects of triptolide (TP) on the expression of interleukin-18 (IL-18) and its receptor in phorbol 12-myristate 13-acetate (PMA)-stimulated rheumatoid arthritis synovial fibroblasts (RASF). triptolide 33-43 interleukin 18 Homo sapiens 70-84 19737478-1 2009 AIM: To determine the effects of triptolide (TP) on the expression of interleukin-18 (IL-18) and its receptor in phorbol 12-myristate 13-acetate (PMA)-stimulated rheumatoid arthritis synovial fibroblasts (RASF). triptolide 33-43 interleukin 18 Homo sapiens 86-91 19737478-1 2009 AIM: To determine the effects of triptolide (TP) on the expression of interleukin-18 (IL-18) and its receptor in phorbol 12-myristate 13-acetate (PMA)-stimulated rheumatoid arthritis synovial fibroblasts (RASF). triptolide 45-47 interleukin 18 Homo sapiens 70-84 19737478-1 2009 AIM: To determine the effects of triptolide (TP) on the expression of interleukin-18 (IL-18) and its receptor in phorbol 12-myristate 13-acetate (PMA)-stimulated rheumatoid arthritis synovial fibroblasts (RASF). triptolide 45-47 interleukin 18 Homo sapiens 86-91 19737478-1 2009 AIM: To determine the effects of triptolide (TP) on the expression of interleukin-18 (IL-18) and its receptor in phorbol 12-myristate 13-acetate (PMA)-stimulated rheumatoid arthritis synovial fibroblasts (RASF). Tetradecanoylphorbol Acetate 113-144 interleukin 18 Homo sapiens 70-84 19737478-1 2009 AIM: To determine the effects of triptolide (TP) on the expression of interleukin-18 (IL-18) and its receptor in phorbol 12-myristate 13-acetate (PMA)-stimulated rheumatoid arthritis synovial fibroblasts (RASF). Tetradecanoylphorbol Acetate 113-144 interleukin 18 Homo sapiens 86-91 19737478-1 2009 AIM: To determine the effects of triptolide (TP) on the expression of interleukin-18 (IL-18) and its receptor in phorbol 12-myristate 13-acetate (PMA)-stimulated rheumatoid arthritis synovial fibroblasts (RASF). Tetradecanoylphorbol Acetate 146-149 interleukin 18 Homo sapiens 70-84 19737478-1 2009 AIM: To determine the effects of triptolide (TP) on the expression of interleukin-18 (IL-18) and its receptor in phorbol 12-myristate 13-acetate (PMA)-stimulated rheumatoid arthritis synovial fibroblasts (RASF). Tetradecanoylphorbol Acetate 146-149 interleukin 18 Homo sapiens 86-91 20641604-0 2004 (64)Cu-1,4,7,10-Tetraazacyclododecane-N,N",N"",N"""-tetraacetic acid-interleukin-18-binding protein-Fc Interleukin-18 (IL-18) is a proinflammatory cytokine produced by macrophages and activated T cells (1, 2), and it plays an important role in inflammation and immune response (3, 4). cu-1,4,7,10-tetraazacyclododecane-n,n",n"",n"""-tetraacetic 4-63 interleukin 18 Homo sapiens 69-83 19456233-5 2009 In response to BmA, purified monocytes from infected individuals also expressed significantly lower levels of interleukin (IL)-12 and IL-18 but, in contrast, expressed significantly higher levels of transforming growth factor beta, IL-10, and suppressor of cytokine signaling 1 mRNA. bma 15-18 interleukin 18 Homo sapiens 134-139 19439372-4 2009 Aluminum adjuvants activate the nucleotide-binding domain and leucine-rich-repeat-containing gene family pyrin-domain-containing 3 (known as NLRP3 or NALP3) inflammasome to activate caspase-1 and to induce proinflammatory cytokines interleukin (IL)-1beta and IL-18 by innate cells. Aluminum 0-8 interleukin 18 Homo sapiens 259-264 20641604-0 2004 (64)Cu-1,4,7,10-Tetraazacyclododecane-N,N",N"",N"""-tetraacetic acid-interleukin-18-binding protein-Fc Interleukin-18 (IL-18) is a proinflammatory cytokine produced by macrophages and activated T cells (1, 2), and it plays an important role in inflammation and immune response (3, 4). cu-1,4,7,10-tetraazacyclododecane-n,n",n"",n"""-tetraacetic 4-63 interleukin 18 Homo sapiens 103-117 20641604-0 2004 (64)Cu-1,4,7,10-Tetraazacyclododecane-N,N",N"",N"""-tetraacetic acid-interleukin-18-binding protein-Fc Interleukin-18 (IL-18) is a proinflammatory cytokine produced by macrophages and activated T cells (1, 2), and it plays an important role in inflammation and immune response (3, 4). cu-1,4,7,10-tetraazacyclododecane-n,n",n"",n"""-tetraacetic 4-63 interleukin 18 Homo sapiens 119-124 19470251-0 2009 [Interleukin-18 expression in peripheral blood mononuclear cells in children with steroid-resistant nephrotic syndrome]. Steroids 82-89 interleukin 18 Homo sapiens 1-15 19414795-10 2009 In conclusion, our results indicate that human macrophages sense trichothecene mycotoxins as a danger signal, which activates caspase-1, and further enables the secretion of IL-1beta and IL-18 from the LPS-primed cells. trichothecene mycotoxins 65-89 interleukin 18 Homo sapiens 187-192 19563734-3 2009 The flow cytometry showed that non-selective CysLT1R and CysLT2R antagonist BAY-u9773 could attenuate the early stage apoptosis mediated by IL-18 whereas CysLT1R antagonist Montelukast couldn"t. BAY u9773 76-85 interleukin 18 Homo sapiens 140-145 19563734-4 2009 Also, pretreatment with BAY-u9773 suppressed calcium influx of HUVECs induced by IL-18 whereas Montelukast didn"t work. BAY u9773 24-33 interleukin 18 Homo sapiens 81-86 19563734-4 2009 Also, pretreatment with BAY-u9773 suppressed calcium influx of HUVECs induced by IL-18 whereas Montelukast didn"t work. Calcium 45-52 interleukin 18 Homo sapiens 81-86 19563734-5 2009 The observation that progression of cell death aggravated by IL-18 could be attenuated by BAY-u9773 may offer a chance to develop a novel way to treat arteriosclerosis. BAY u9773 90-99 interleukin 18 Homo sapiens 61-66 19414795-6 2009 As a result, satratoxin-positive S. chartarum activated inflammasome-associated caspase-1, which is needed for proteolytic processing of IL-1beta and IL-18. satratoxin 13-23 interleukin 18 Homo sapiens 150-155 19414795-7 2009 Furthermore, purified trichothecene mycotoxins, roridin A, verrucarin A, and T-2 toxin activated caspase-1, and these mycotoxins also strongly enhanced LPS-dependent secretion of IL-1beta and IL-18. trichothecene mycotoxins 22-46 interleukin 18 Homo sapiens 192-197 19414795-7 2009 Furthermore, purified trichothecene mycotoxins, roridin A, verrucarin A, and T-2 toxin activated caspase-1, and these mycotoxins also strongly enhanced LPS-dependent secretion of IL-1beta and IL-18. roridin A 48-57 interleukin 18 Homo sapiens 192-197 19414795-7 2009 Furthermore, purified trichothecene mycotoxins, roridin A, verrucarin A, and T-2 toxin activated caspase-1, and these mycotoxins also strongly enhanced LPS-dependent secretion of IL-1beta and IL-18. muconomycin A 59-71 interleukin 18 Homo sapiens 192-197 19054512-2 2009 This prospective clinical study aimed at evaluating the association between these and plasma interleukin-18 (IL-18) and neopterin levels. Neopterin 120-129 interleukin 18 Homo sapiens 93-107 19054512-2 2009 This prospective clinical study aimed at evaluating the association between these and plasma interleukin-18 (IL-18) and neopterin levels. Neopterin 120-129 interleukin 18 Homo sapiens 109-114 18940019-3 2009 Single nucleotide polymorphisms of the interleukin-18 gene at positions -607 (cytosine/adenine) and -137 (guanine/cytosine) were analysed by sequence-specific polymerase chain reaction. Cytosine 78-86 interleukin 18 Homo sapiens 39-53 19678540-0 2009 The interleukin-18 inhibitory activities of echinocystic acid and its saponins from Impatiens pritzellii var. echinocystic acid 44-61 interleukin 18 Homo sapiens 4-18 19678540-0 2009 The interleukin-18 inhibitory activities of echinocystic acid and its saponins from Impatiens pritzellii var. Saponins 70-78 interleukin 18 Homo sapiens 4-18 19678540-4 2009 Three of them, 1, 2 and 6, showed obvious activity to inhibit the production of IL-18, especially the ester saponins with a sugar chain at C-28, 6. Esters 102-107 interleukin 18 Homo sapiens 80-85 19678540-4 2009 Three of them, 1, 2 and 6, showed obvious activity to inhibit the production of IL-18, especially the ester saponins with a sugar chain at C-28, 6. Saponins 108-116 interleukin 18 Homo sapiens 80-85 19678540-4 2009 Three of them, 1, 2 and 6, showed obvious activity to inhibit the production of IL-18, especially the ester saponins with a sugar chain at C-28, 6. Sugars 124-129 interleukin 18 Homo sapiens 80-85 19678540-4 2009 Three of them, 1, 2 and 6, showed obvious activity to inhibit the production of IL-18, especially the ester saponins with a sugar chain at C-28, 6. Carbon 139-140 interleukin 18 Homo sapiens 80-85 19342689-7 2009 We then transfected FLS with an antisense oligonucleotide targeting miR-346 and found that, in these conditions, IL-18 release could be measured upon LPS activation of FLS. Oligonucleotides 42-57 interleukin 18 Homo sapiens 113-118 18940019-3 2009 Single nucleotide polymorphisms of the interleukin-18 gene at positions -607 (cytosine/adenine) and -137 (guanine/cytosine) were analysed by sequence-specific polymerase chain reaction. Adenine 87-94 interleukin 18 Homo sapiens 39-53 18940019-3 2009 Single nucleotide polymorphisms of the interleukin-18 gene at positions -607 (cytosine/adenine) and -137 (guanine/cytosine) were analysed by sequence-specific polymerase chain reaction. Guanine 106-113 interleukin 18 Homo sapiens 39-53 18940019-3 2009 Single nucleotide polymorphisms of the interleukin-18 gene at positions -607 (cytosine/adenine) and -137 (guanine/cytosine) were analysed by sequence-specific polymerase chain reaction. Cytosine 114-122 interleukin 18 Homo sapiens 39-53 19027720-6 2009 Furthermore, BIRB796 and compound 2 inhibited the production of TNF-alpha in THP-1 monocytes and the IL-12/IL-18-induced production of interferon-gamma in human T-cells with similar potencies. doramapimod 13-20 interleukin 18 Homo sapiens 107-112 19333898-3 2009 Preclinical studies of R-406 or fostamatinib demonstrated a significant reduction in major inflammatory mediators such as TNFalpha, IL-1, IL-6 and IL-18, leading to reduced inflammation and bone degradation in models of RA. fostamatinib 32-44 interleukin 18 Homo sapiens 147-152 19234499-4 2009 Experimental evidence indicates that the expression of IL-18 and/or its receptor can be induced by catecholamines or angiotensin, two factors that are involved in the pathophysiology of hypertension. Catecholamines 99-113 interleukin 18 Homo sapiens 55-60 19403407-6 2009 CONCLUSION: IL-18 can promote PGE2 production, which causes cartilage degradation in OA, thus therapies targeting this cytokine may prove an effective approach to early OA treatment. Dinoprostone 30-34 interleukin 18 Homo sapiens 12-17 19092166-8 2009 There was a significant interaction between fasting glucose and IL-18 (P = 0.008) and IL-6 (P = 0.024) but not CRP. Glucose 52-59 interleukin 18 Homo sapiens 64-69 19092166-9 2009 Elevated fasting glucose (>6.2 mmol/l) markedly increased the predictive power of inflammatory markers (IL-18: 5.5 [1.4-21.1], IL-6: 3.5 [1.0-11.8], and CRP: 3.5 [1.0-11.9]). Glucose 17-24 interleukin 18 Homo sapiens 107-112 19092166-10 2009 For IL-18, there was a stepwise increase in event rate by quartiles of fasting glucose. Glucose 79-86 interleukin 18 Homo sapiens 4-9 19092166-11 2009 CONCLUSIONS: IL-18 was an independent predictor of cardiovascular events in subjects with metabolic syndrome and even more so in the presence of elevated fasting glucose. Glucose 162-169 interleukin 18 Homo sapiens 13-18 19756411-0 2009 Intermittent high glucose stimulate MCP-l, IL-18, and PAI-1, but inhibit adiponectin expression and secretion in adipocytes dependent of ROS. Glucose 18-25 interleukin 18 Homo sapiens 43-48 19756411-3 2009 The aim of this study was to investigate the effect of intermittent high glucose on the expression of IL-18, MCP-1, and PAI-1 and adiponectin in 3T3-L1 adipocytes. Glucose 73-80 interleukin 18 Homo sapiens 102-107 19756411-6 2009 Stable high glucose significantly increased expression and secretion of IL-18, MCP-1, and PAI-1, and reduced adiponectin expression and secretion compared to normal glucose conditions.These effects were significantly greater under intermittent high glucose conditions compared to stable high glucose. Glucose 12-19 interleukin 18 Homo sapiens 72-77 18779390-6 2008 IL-12 and IL-18 stimulated autoreactively activated NKT cells to secrete IFN-gamma, and this was mediated by Janus kinase-signal transducers and activators of transcription (JAK-STAT)-dependent signaling without induction of calcium flux. Calcium 225-232 interleukin 18 Homo sapiens 10-15 18520705-5 2008 However, pretreatment with the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 increased apoptosis more effectively in IL-18- than in LPS-stimulated cells, whereas the ERK inhibitor PD98059 had the same effect in both. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 78-86 interleukin 18 Homo sapiens 127-132 18514203-6 2009 Levels of IL-18 above this threshold modify the fully adjusted risk of future CVD conferred by elevated levels of total cholesterol (P(interaction)=0.02). Cholesterol 120-131 interleukin 18 Homo sapiens 10-15 19077897-10 2008 Serum levels of IL-18 and IFN-gamma were significantly elevated in the AR group with compared with the no AR group. Argon 71-73 interleukin 18 Homo sapiens 16-21 19077897-10 2008 Serum levels of IL-18 and IFN-gamma were significantly elevated in the AR group with compared with the no AR group. Argon 106-108 interleukin 18 Homo sapiens 16-21 19077897-11 2008 In the AR group, patients with the -137GG genotype had significantly higher IL-18 serum levels compared to other genotypes. Argon 7-9 interleukin 18 Homo sapiens 76-81 18523012-0 2008 ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1beta and IL-18 secretion in an autocrine way. Adenosine Triphosphate 0-3 interleukin 18 Homo sapiens 104-109 18819819-0 2008 IL-18 is correlated with type-2 immune response in children with steroid sensitive nephrotic syndrome. Steroids 65-72 interleukin 18 Homo sapiens 0-5 18681455-2 2008 We demonstrate the use of zinc oxide nanorod (ZnO NR) arrays in a straightforward, reliable, and ultrasensitive detection of the cytokines interleukin-18 and tumor necrosis factor-alpha. Zinc Oxide 26-36 interleukin 18 Homo sapiens 139-185 18681455-2 2008 We demonstrate the use of zinc oxide nanorod (ZnO NR) arrays in a straightforward, reliable, and ultrasensitive detection of the cytokines interleukin-18 and tumor necrosis factor-alpha. Zinc Oxide 46-49 interleukin 18 Homo sapiens 139-185 18562922-8 2008 The possible cellular and molecular mechanisms concerning IL-18-induced myocardial injury include induction of inflammation, increased apoptosis, a cardiac hypertrophy effect, modulation of mitogen activated protein kinase activation, and changes in intracellular calcium. Calcium 264-271 interleukin 18 Homo sapiens 58-63 18622761-3 2008 Croton oil, an inflammation inducer, induced transgenic GM-CSF and TNF-alpha promoter activities in skin epidermis 6-fold and 3.4-fold, respectively; however, it produced a less than 1.5-fold and 1.7-fold change in IL-1beta and IL-18 promoter activity, respectively. Croton Oil 0-10 interleukin 18 Homo sapiens 228-233 19097518-2 2008 IL-18 is a pleiotropic cytokine with a capacity for both ThI and Th2 polarization. 2-acetyl-4(5)-tetrahydroxybutylimidazole 57-60 interleukin 18 Homo sapiens 0-5 18992197-1 2008 AIM: To study the clinical significance of early diagnosis and differential diagnosis of IL-18 by observing its changes in renal allograft recipients with infection, acute rejection and CsA-induced nephrotoxicity. Cyclosporine 186-189 interleukin 18 Homo sapiens 89-94 18992197-6 2008 The level of IL-18 rapidly decreased with effective methylpredmisolone impaction therapy, but persisted at high level when the therapy did not work. methylpredmisolone 52-70 interleukin 18 Homo sapiens 13-18 18706445-5 2008 In addition, PD98059 (an ERK1/2 MAPK inhibitor) and SP600125 (a JNK inhibitor) attenuated IL-18-induced ULBP2 expression in a dose-dependent manner. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13-20 interleukin 18 Homo sapiens 90-95 18706445-5 2008 In addition, PD98059 (an ERK1/2 MAPK inhibitor) and SP600125 (a JNK inhibitor) attenuated IL-18-induced ULBP2 expression in a dose-dependent manner. pyrazolanthrone 52-60 interleukin 18 Homo sapiens 90-95 18577586-5 2008 Macrophages deficient in components of the Nalp3 inflammasome were incapable of secreting the proinflammatory cytokines interleukin (IL)-1beta and IL-18 in response to silica. Silicon Dioxide 168-174 interleukin 18 Homo sapiens 147-152 18523012-5 2008 Here, we show that in primary human monocytes microbial components acting on different pathogen-sensing receptors and the danger-associated molecule uric acid are all competent to induce maturation and secretion of IL-1beta and IL-18 through a process that involves as a first event the extracellular release of endogenous ATP. Uric Acid 149-158 interleukin 18 Homo sapiens 228-233 18523012-5 2008 Here, we show that in primary human monocytes microbial components acting on different pathogen-sensing receptors and the danger-associated molecule uric acid are all competent to induce maturation and secretion of IL-1beta and IL-18 through a process that involves as a first event the extracellular release of endogenous ATP. Adenosine Triphosphate 323-326 interleukin 18 Homo sapiens 228-233 18523012-11 2008 Thus, stimuli acting on different pathogen-sensing receptors converge on a common pathway where ATP externalization is the first step in the cascade of events leading to inflammasome activation and IL-1beta and IL-18 secretion. Adenosine Triphosphate 96-99 interleukin 18 Homo sapiens 211-216 18064631-7 2008 Investigation of signaling intermediates revealed that IL-18 stimulated PI3 kinase activity (blocked by wortmannin, LY294002, or Ad.dnPI3Kp85), and Akt phosphorylation and kinase activity (blocked by SH-5 or Ad.dnAkt). Wortmannin 104-114 interleukin 18 Homo sapiens 55-60 18516710-0 2008 Inhibitory effect of triptolide on interleukin-18 and its receptor in rheumatoid arthritis synovial fibroblasts. triptolide 21-31 interleukin 18 Homo sapiens 35-49 18516710-1 2008 OBJECTIVE: To determine the effects of triptolide (TP) on the expression of interleukin-18 (IL-18) and its receptor in phorbol 12-myristate 13-acetate (PMA)-stimulated rheumatoid arthritis synovial fibroblasts (RASF). triptolide 39-49 interleukin 18 Homo sapiens 76-90 18516710-1 2008 OBJECTIVE: To determine the effects of triptolide (TP) on the expression of interleukin-18 (IL-18) and its receptor in phorbol 12-myristate 13-acetate (PMA)-stimulated rheumatoid arthritis synovial fibroblasts (RASF). triptolide 39-49 interleukin 18 Homo sapiens 92-97 18516710-1 2008 OBJECTIVE: To determine the effects of triptolide (TP) on the expression of interleukin-18 (IL-18) and its receptor in phorbol 12-myristate 13-acetate (PMA)-stimulated rheumatoid arthritis synovial fibroblasts (RASF). triptolide 51-53 interleukin 18 Homo sapiens 76-90 18516710-1 2008 OBJECTIVE: To determine the effects of triptolide (TP) on the expression of interleukin-18 (IL-18) and its receptor in phorbol 12-myristate 13-acetate (PMA)-stimulated rheumatoid arthritis synovial fibroblasts (RASF). triptolide 51-53 interleukin 18 Homo sapiens 92-97 18516710-1 2008 OBJECTIVE: To determine the effects of triptolide (TP) on the expression of interleukin-18 (IL-18) and its receptor in phorbol 12-myristate 13-acetate (PMA)-stimulated rheumatoid arthritis synovial fibroblasts (RASF). Tetradecanoylphorbol Acetate 119-150 interleukin 18 Homo sapiens 76-90 18516710-1 2008 OBJECTIVE: To determine the effects of triptolide (TP) on the expression of interleukin-18 (IL-18) and its receptor in phorbol 12-myristate 13-acetate (PMA)-stimulated rheumatoid arthritis synovial fibroblasts (RASF). Tetradecanoylphorbol Acetate 119-150 interleukin 18 Homo sapiens 92-97 18516710-1 2008 OBJECTIVE: To determine the effects of triptolide (TP) on the expression of interleukin-18 (IL-18) and its receptor in phorbol 12-myristate 13-acetate (PMA)-stimulated rheumatoid arthritis synovial fibroblasts (RASF). Tetradecanoylphorbol Acetate 152-155 interleukin 18 Homo sapiens 76-90 18516710-1 2008 OBJECTIVE: To determine the effects of triptolide (TP) on the expression of interleukin-18 (IL-18) and its receptor in phorbol 12-myristate 13-acetate (PMA)-stimulated rheumatoid arthritis synovial fibroblasts (RASF). Tetradecanoylphorbol Acetate 152-155 interleukin 18 Homo sapiens 92-97 18064631-7 2008 Investigation of signaling intermediates revealed that IL-18 stimulated PI3 kinase activity (blocked by wortmannin, LY294002, or Ad.dnPI3Kp85), and Akt phosphorylation and kinase activity (blocked by SH-5 or Ad.dnAkt). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 116-124 interleukin 18 Homo sapiens 55-60 18204966-8 2008 A role for IL-18 in the pathogenesis of AIU is also suggested. 5'-amino-5-iodo-2',5'-dideoxyuridine 40-43 interleukin 18 Homo sapiens 11-16 18469453-0 2008 Ritonavir and disulfiram may be synergistic in lowering active interleukin-18 levels in acute pancreatitis, and thereby hasten recovery. Ritonavir 0-9 interleukin 18 Homo sapiens 63-77 18469453-0 2008 Ritonavir and disulfiram may be synergistic in lowering active interleukin-18 levels in acute pancreatitis, and thereby hasten recovery. Disulfiram 14-24 interleukin 18 Homo sapiens 63-77 18469453-5 2008 Since ritonavir is well tolerated in short-term use it may therefore prove useful in treating acute pancreatitis by lowering caspase-1 mediated IL-18 formation and the many inflammatory mediators downstream from that. Ritonavir 6-15 interleukin 18 Homo sapiens 144-149 18469453-9 2008 Given the current morbidity and mortality of pancreatitis, research should be directed to ritonavir and disulfiram as treatment options for illnesses like pancreatitis where excessive IL-18 contributes to pathology. Ritonavir 90-99 interleukin 18 Homo sapiens 184-189 18469453-9 2008 Given the current morbidity and mortality of pancreatitis, research should be directed to ritonavir and disulfiram as treatment options for illnesses like pancreatitis where excessive IL-18 contributes to pathology. Disulfiram 104-114 interleukin 18 Homo sapiens 184-189 18359638-6 2008 IL-18 correlated positively with HbA(1c) (r=0.32, P=0.01) and postprandial blood glucose (PPBG) (r=0.26, P=0.02); and negatively with HDL-cholesterol (HDL-C) (r=-0.38, P=0.007). Glucose 81-88 interleukin 18 Homo sapiens 0-5 18359638-6 2008 IL-18 correlated positively with HbA(1c) (r=0.32, P=0.01) and postprandial blood glucose (PPBG) (r=0.26, P=0.02); and negatively with HDL-cholesterol (HDL-C) (r=-0.38, P=0.007). ppbg 90-94 interleukin 18 Homo sapiens 0-5 18359638-6 2008 IL-18 correlated positively with HbA(1c) (r=0.32, P=0.01) and postprandial blood glucose (PPBG) (r=0.26, P=0.02); and negatively with HDL-cholesterol (HDL-C) (r=-0.38, P=0.007). Cholesterol 138-149 interleukin 18 Homo sapiens 0-5 18359638-7 2008 By linear regression analysis, PPBG was determined as the most explanatory parameter for the alterations in serum IL-18 levels (P=0.02). ppbg 31-35 interleukin 18 Homo sapiens 114-119 18215737-0 2008 Carbon monoxide donors or heme oxygenase-1 (HO-1) overexpression blocks interleukin-18-mediated NF-kappaB-PTEN-dependent human cardiac endothelial cell death. Carbon Monoxide 0-15 interleukin 18 Homo sapiens 72-86 18086672-5 2008 IL-18 induces NFATc4 phosphorylation (Ser(676)), nuclear translocation, and in vivo DNA binding. Serine 38-41 interleukin 18 Homo sapiens 0-5 18504197-7 2008 In the cancer patients, serum IL-18 was 90.668-/+20.363 pg/ml for TT-AA genotype, 119.641-/+15.338 pg/ml for GG-CC genotype, and 112.793-/+13.326 pg/ml for TG-AC genotype, showing significant differences (F=11.307, P=0.000). Thioguanine 156-158 interleukin 18 Homo sapiens 30-35 18215737-1 2008 The objective of this study was to determine whether heme oxygenase-1 (HO-1) or heme metabolites exert cytoprotective effects on interleukin-18-mediated endothelial cell (EC) death. Heme 53-57 interleukin 18 Homo sapiens 129-143 18215737-5 2008 Overexpression of HO-1, treatment with HO-1 inducer hemin, or the CO donor cobalt (III) protoporphyrin IX all reversed IL-18-mediated NF-kappaB activation, PTEN induction, Akt suppression, and EC death. cobaltiprotoporphyrin 75-105 interleukin 18 Homo sapiens 119-124 18215737-7 2008 In addition, the CO donors CORM-1 and CORM-3 and the heme metabolites biliverdin and bilirubin attenuated IL-18-induced EC death via a similar signaling pathway. Heme 53-57 interleukin 18 Homo sapiens 106-111 18215737-7 2008 In addition, the CO donors CORM-1 and CORM-3 and the heme metabolites biliverdin and bilirubin attenuated IL-18-induced EC death via a similar signaling pathway. Biliverdine 70-80 interleukin 18 Homo sapiens 106-111 18215737-7 2008 In addition, the CO donors CORM-1 and CORM-3 and the heme metabolites biliverdin and bilirubin attenuated IL-18-induced EC death via a similar signaling pathway. Bilirubin 85-94 interleukin 18 Homo sapiens 106-111 18215737-12 2008 HO-1 overexpression, HO-1 induction, or treatment with heme metabolites all reverse IL-18-mediated p38alpha MAPK and NF-kappaB activation, PTEN induction, Akt suppression, and EC death. Heme 55-59 interleukin 18 Homo sapiens 84-89 17716784-4 2008 Under certain conditions, however, stress hormones, substance P, ATP and the activation of the corticotropin-releasing hormone/substance P-histamine axis may actually facilitate inflammation, through induction of interleukin (IL)-1, IL-6, IL-8, IL-18, tumor necrosis factor (TNF)-alpha and CRP production. Histamine 139-148 interleukin 18 Homo sapiens 245-250 17911094-1 2008 BACKGROUND: Urinary interleukin-18 (uIL-18) is an earlier acute kidney injury (AKI) biomarker than serum creatinine (SCr) in specific populations. Creatinine 105-115 interleukin 18 Homo sapiens 20-34 17879274-8 2008 Mucosal IL-18 was greater in children with CD and UC/IBDU than in controls (P < 0.01). isobutylidene diurea 53-57 interleukin 18 Homo sapiens 8-13 18391570-7 2008 RESULTS: Urinary IL-18 concentration was significantly higher in group I (213.51 +/- 162.15 pg/mg Cr) compared to group II (64.74 +/- 10.95 pg/mg Cr) and to normal controls (37.03 +/- 4.1 pg/mg Cr, p < 0.001). Creatinine 98-100 interleukin 18 Homo sapiens 17-22 18391570-7 2008 RESULTS: Urinary IL-18 concentration was significantly higher in group I (213.51 +/- 162.15 pg/mg Cr) compared to group II (64.74 +/- 10.95 pg/mg Cr) and to normal controls (37.03 +/- 4.1 pg/mg Cr, p < 0.001). Creatinine 146-148 interleukin 18 Homo sapiens 17-22 17597823-5 2007 Furthermore, anisomycin increased the mRNA expression of IL-18 through a p38 MAPK-dependent but caspase-1-independent mechanism, reaching a maximum level after 12 hours of stimulation. Anisomycin 13-23 interleukin 18 Homo sapiens 57-62 18925531-10 2008 Increased levels of urine NGAL and IL-18 2 h postoperation were significantly correlated with increased level of serum creatinine 12 h postoperation. Creatinine 119-129 interleukin 18 Homo sapiens 35-40 17597823-6 2007 Finally, anisomycin caused a rapid (4 hours) increase in the secretion of proIL-18 and active IL-18. Anisomycin 9-19 interleukin 18 Homo sapiens 77-82 18184040-4 2007 ZnCl(2) also amplified IFN-gamma production under the influence of IL-12 or IL-18, whereas IL-1beta-induced IL-8 expression was not enhanced by the addition of ZnCl(2), indicating that the effect observed on cytokine-induced IFN-gamma is not of a general and unspecific nature. zncl 0-4 interleukin 18 Homo sapiens 76-81 17965486-8 2007 Multiple stepwise logistic regression analysis demonstrated that high IL-18 level (>or=780 pg/ml) (p<0.0001), together with creatinine level (p=0.024), were independently predictive of 90-day MACO. Creatinine 130-140 interleukin 18 Homo sapiens 70-75 17922692-3 2007 METHOD OF STUDY: A case-control study was conducted to determine the association between the IL12 (I/D) and IL18 (-607C>A, -137G>C) gene polymorphisms and the risk of RSA in 125 women with RSA and in 136 controls. rabbit sperm membrane autoantigen 173-176 interleukin 18 Homo sapiens 108-112 17922692-3 2007 METHOD OF STUDY: A case-control study was conducted to determine the association between the IL12 (I/D) and IL18 (-607C>A, -137G>C) gene polymorphisms and the risk of RSA in 125 women with RSA and in 136 controls. rabbit sperm membrane autoantigen 195-198 interleukin 18 Homo sapiens 108-112 17608757-7 2007 In the multiple regression analysis, preoperative values of IL-18 remained significantly associated with preoperative triglycerides (beta = 0.47, P = 0.005) and TNFR2 (beta = 0.47, P = 0.004). Triglycerides 118-131 interleukin 18 Homo sapiens 60-65 17608757-9 2007 Postoperative IL-18 concentrations in the multiple regression analysis were significantly associated with postoperative homeostasis model assessment of insulin resistance (HOMA-IR) (beta = 0.092, P = 0.019) and triglycerides (beta = 0.40, P = 0.036). Triglycerides 211-224 interleukin 18 Homo sapiens 14-19 17626902-3 2007 In univariable analysis, IL-18 levels associated with traditional cardiovascular risk factors and particularly with components of the metabolic syndrome (MS, P<0.01 for trend across the number of MS components); IL-18 also associated with coronary artery calcium (CAC) scores measured by electron beam computed tomography and aortic plaque measured by MRI (P<0.01 for each). Calcium 258-265 interleukin 18 Homo sapiens 25-30 18282427-0 2007 [Therapeutic effect of anti interleukin-18 antibody in the adriamycin-induced modal of minimal-change nephrotic syndrome]. Doxorubicin 59-69 interleukin 18 Homo sapiens 28-42 17907957-4 2007 IL-18 levels reflect the severity of acute pancreatitis and display a significant negative correlation with the concentrations of antioxidative damage factors, serum selenium and glutathione peroxidases (GPx). Selenium 166-174 interleukin 18 Homo sapiens 0-5 17626902-3 2007 In univariable analysis, IL-18 levels associated with traditional cardiovascular risk factors and particularly with components of the metabolic syndrome (MS, P<0.01 for trend across the number of MS components); IL-18 also associated with coronary artery calcium (CAC) scores measured by electron beam computed tomography and aortic plaque measured by MRI (P<0.01 for each). Calcium 258-265 interleukin 18 Homo sapiens 215-220 17509061-5 2007 However, in ASST-positive patients, IL-18 levels paralleled clinical severity scores and showed a tendency to correlate with in vitro histamine release. Histamine 134-143 interleukin 18 Homo sapiens 36-41 17683383-0 2007 Relationship between Kaposi"s varicelliform eruption in Japanese patients with atopic dermatitis treated with tacrolimus ointment and genetic polymorphisms in the IL-18 gene promoter region. Tacrolimus 110-120 interleukin 18 Homo sapiens 163-168 18073617-10 2007 Survival in the AET treatment group was associated with reduced levels of IL-6, IL-10, and IL-18, and enhanced IFN-gamma and IL-2 levels. beta-Aminoethyl Isothiourea 16-19 interleukin 18 Homo sapiens 91-96 17692395-3 2007 Extracellular ATP stimulates a family of receptors, named P2, one of which, P2X(7), is a potent mediator of interleukin (IL)-1beta and IL-18 processing and release. Adenosine Triphosphate 14-17 interleukin 18 Homo sapiens 135-140 17683383-4 2007 IL-18 gene promoter polymorphisms were analyzed in 21 AD patients treated with tacrolimus ointment and in 100 healthy volunteers. Tacrolimus 79-89 interleukin 18 Homo sapiens 0-5 17683383-5 2007 Six AD patients with Kaposi"s varicelliform eruption during the treatment with tacrolimus ointment showed significantly higher frequency in G-to-C mutations at the IL-18 gene promoter region -137 compared with 15 AD patients without Kaposi"s varicelliform eruption. Tacrolimus 79-89 interleukin 18 Homo sapiens 164-169 17683383-7 2007 These results suggest that the onset of Kaposi"s varicelliform eruption following the treatment with tacrolimus ointment is associated with the mutation of G-to-C in the IL-18 gene promoter region -137, and that caution is required when using tacrolimus ointment for treating AD patients with this mutation. Tacrolimus 101-111 interleukin 18 Homo sapiens 170-175 17683383-7 2007 These results suggest that the onset of Kaposi"s varicelliform eruption following the treatment with tacrolimus ointment is associated with the mutation of G-to-C in the IL-18 gene promoter region -137, and that caution is required when using tacrolimus ointment for treating AD patients with this mutation. Tacrolimus 243-253 interleukin 18 Homo sapiens 170-175 17532765-7 2007 Higher levels of IL-18 were found in patients treated with ranitidine compared with healthy controls. Ranitidine 59-69 interleukin 18 Homo sapiens 17-22 17429439-6 2007 We show here that key components of the inflammasome are present in human keratinocytes and that CS like trinitro-chlorobenzene induce caspase-1/ASC dependent IL-1beta and IL-18 processing and secretion. Cesium 97-99 interleukin 18 Homo sapiens 172-177 17429439-6 2007 We show here that key components of the inflammasome are present in human keratinocytes and that CS like trinitro-chlorobenzene induce caspase-1/ASC dependent IL-1beta and IL-18 processing and secretion. Picryl Chloride 105-127 interleukin 18 Homo sapiens 172-177 17021654-6 2007 Both mitomycin C and cisplatin induced apoptosis in C-33A cells via caspase-8 and -3 processing in a Fas/FasL-dependent manner and also suppressed IL-18 expression, while they down-regulated IkappaB expression and up-regulated p65 expression. Mitomycin 5-16 interleukin 18 Homo sapiens 147-152 17021654-6 2007 Both mitomycin C and cisplatin induced apoptosis in C-33A cells via caspase-8 and -3 processing in a Fas/FasL-dependent manner and also suppressed IL-18 expression, while they down-regulated IkappaB expression and up-regulated p65 expression. Cisplatin 21-30 interleukin 18 Homo sapiens 147-152 17021654-7 2007 These results suggest that both mitomycin C and cisplatin induce apoptosis, not only via the caspase-8 and -3 dependent Fas/FasL pathway, but also via the regulation of NF-kappaB activity and IL-18 expression in HPV-negative cervical cancer C-33A cells. Mitomycin 32-43 interleukin 18 Homo sapiens 192-197 17021654-7 2007 These results suggest that both mitomycin C and cisplatin induce apoptosis, not only via the caspase-8 and -3 dependent Fas/FasL pathway, but also via the regulation of NF-kappaB activity and IL-18 expression in HPV-negative cervical cancer C-33A cells. Cisplatin 48-57 interleukin 18 Homo sapiens 192-197 17371542-6 2007 Consistent with these results, we also observed that SPC stimulated the production of interleukin (IL)-12 and IL-18 by DCs. sphingosine phosphorylcholine 53-56 interleukin 18 Homo sapiens 110-115 17374532-5 2007 Adenosine inhibited the IL-18-initiated immune responses. Adenosine 0-9 interleukin 18 Homo sapiens 24-29 17374532-6 2007 The IC(50) values of adenosine for inhibition of the IL-18-enhanced ICAM-1 expression, IFN-gamma production and lymphocyte proliferation were 20 microM, respectively. Adenosine 21-30 interleukin 18 Homo sapiens 53-58 17374532-4 2007 In the present study, we examined the effect of adenosine at increasing concentrations ranging from 0.1 to 100 microM on the IL-18-enhanced expression of ICAM-1, production of IFN-gamma and IL-12 and lymphocyte proliferation during human mixed lymphocyte reaction. Adenosine 48-57 interleukin 18 Homo sapiens 125-130 20409851-10 2007 IL-6, IL-18, sICAM, and MCP-1 levels were reduced by valsartan (three-fold, P < .05). Valsartan 53-62 interleukin 18 Homo sapiens 6-11 17485153-7 2007 Aluminum-containing adjuvants stimulated the release of IL-1beta and IL-18 from DCs via caspase-1 activation. Aluminum 0-8 interleukin 18 Homo sapiens 69-74 17485153-12 2007 These results indicate that aluminum-containing adjuvants activate DCs and influence their ability to direct T(H)1 and T(H)2 responses through the secretion of IL-1beta and IL-18. Aluminum 28-36 interleukin 18 Homo sapiens 173-178 17482516-6 2007 However, the calcineurin inhibitors, tacrolimus and cyclosporine A (CsA), inhibited the IL-18-enhanced cytokine production and lymphocyte proliferation without any effect on the adhesion molecule expression. Tacrolimus 37-47 interleukin 18 Homo sapiens 88-93 17482516-6 2007 However, the calcineurin inhibitors, tacrolimus and cyclosporine A (CsA), inhibited the IL-18-enhanced cytokine production and lymphocyte proliferation without any effect on the adhesion molecule expression. Cyclosporine 52-66 interleukin 18 Homo sapiens 88-93 17482516-6 2007 However, the calcineurin inhibitors, tacrolimus and cyclosporine A (CsA), inhibited the IL-18-enhanced cytokine production and lymphocyte proliferation without any effect on the adhesion molecule expression. Cyclosporine 68-71 interleukin 18 Homo sapiens 88-93 17572009-5 2007 Moreover, the results show that AS101 treatment causes a significant reduction in the active form of IL-18 and IL-1beta in peripheral blood mononuclear cells (PBMC) and in human HaCat keratinocytes. ammonium trichloro(dioxoethylene-O,O'-)tellurate 32-37 interleukin 18 Homo sapiens 101-106 20409851-11 2007 Only IL-18 was reduced by atenolol compared with pretreatment levels (P < .05). Atenolol 26-34 interleukin 18 Homo sapiens 5-10 17310143-3 2007 We have previously demonstrated that elevation of cAMP inhibits this IL-18-induced expression of adhesion molecules. Cyclic AMP 50-54 interleukin 18 Homo sapiens 69-74 17235324-8 2007 The effect of ACTH on IL-18 production was blocked by specific inhibitors of p38 kinase (SB203580) or extracellular signal-regulated kinase (ERK) (PD98059). SB 203580 89-97 interleukin 18 Homo sapiens 22-27 17235324-8 2007 The effect of ACTH on IL-18 production was blocked by specific inhibitors of p38 kinase (SB203580) or extracellular signal-regulated kinase (ERK) (PD98059). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 147-154 interleukin 18 Homo sapiens 22-27 17404311-0 2007 Aluminum hydroxide adjuvants activate caspase-1 and induce IL-1beta and IL-18 release. Aluminum Hydroxide 0-18 interleukin 18 Homo sapiens 72-77 17254563-5 2007 The IC50 values of nicotine for inhibition of the IL-18-enhanced ICAM-1 expression, IFN-gamma production and proliferation were 1, 1 and 2 microM, respectively. Nicotine 19-27 interleukin 18 Homo sapiens 50-55 17310143-4 2007 In the present study, we examined the effect of adenosine on the IL-18-induced up-regulation of ICAM-1 on human monocytes and production of IL-12, IFN-gamma and TNF-alpha by PBMC. Adenosine 48-57 interleukin 18 Homo sapiens 65-70 17310143-7 2007 KEY RESULTS: Adenosine inhibited the IL-18-induced up-regulation of ICAM-1 on human monocytes and it abolished the IL-18-enhanced production of IL-12, IFN-gamma and TNF-alpha. Adenosine 13-22 interleukin 18 Homo sapiens 37-42 17310143-7 2007 KEY RESULTS: Adenosine inhibited the IL-18-induced up-regulation of ICAM-1 on human monocytes and it abolished the IL-18-enhanced production of IL-12, IFN-gamma and TNF-alpha. Adenosine 13-22 interleukin 18 Homo sapiens 115-120 17310143-11 2007 CONCLUSIONS AND IMPLICATIONS: Adenosine differentially regulates IL-18-induced adhesion molecule expression and cytokine production through several subtypes of its receptors. Adenosine 30-39 interleukin 18 Homo sapiens 65-70 17132626-7 2007 In parallel, ATP-mediated ROS-dependent PI3K is required for activation of caspase-1 and secretion of IL-1beta and IL-18. Reactive Oxygen Species 26-29 interleukin 18 Homo sapiens 115-120 17395047-5 2007 Candesartan decreased Nt-proBNP (median value = 12.4% versus -20.4%; [candesartan] P = .05), and high-sensitivity C-reactive protein (hsCRP) (+5.32% versus -20.3% [candesartan]; P = 0.046), without significantly influencing serum interleukin-6, interleukin-18, adhesion molecules, or markers of oxidative stress. candesartan 0-11 interleukin 18 Homo sapiens 245-259 17132626-7 2007 In parallel, ATP-mediated ROS-dependent PI3K is required for activation of caspase-1 and secretion of IL-1beta and IL-18. Adenosine Triphosphate 13-16 interleukin 18 Homo sapiens 115-120 16979683-4 2007 We introduced alanine substitutions to known receptor binding sites of human IL-18 and found that only the substitution of Leu5 reduced the binding affinity of IL-18 with IL-18BP of variola virus (varvIL-18BP) by more than 4-fold. Alanine 14-21 interleukin 18 Homo sapiens 77-82 16979683-4 2007 We introduced alanine substitutions to known receptor binding sites of human IL-18 and found that only the substitution of Leu5 reduced the binding affinity of IL-18 with IL-18BP of variola virus (varvIL-18BP) by more than 4-fold. Alanine 14-21 interleukin 18 Homo sapiens 160-165 17190649-5 2007 Results indicated that serum interleukin (IL)-18 concentrations were significantly higher in PD and low creatinine clearance pre-dialysis CRF (LCC) patients than HD patients (both p < 0.05). Creatinine 104-114 interleukin 18 Homo sapiens 29-48 17399992-4 2007 The relationship between these transcription factors and IL-18 expression was confirmed using curcumin and PDTC, two inhibitors of NF-kappaB. Curcumin 94-102 interleukin 18 Homo sapiens 57-62 17399992-5 2007 Our results show that UVB and curcumin or PDTC co-treatment led to a down-regulation of IL-18 expression associated with an inhibition of NF-kappaB DNA binding. Curcumin 30-38 interleukin 18 Homo sapiens 88-93 17827967-3 2007 In this study, we wanted to estimate the levels of CXCL11 chemokine and interleukin-18 (IL-18), a proinflammatory cytokine, in sera of relapsing-remitting MS (RRMS) patients, both before and after methylprednisolone (MP) treatment, and to compare the results with those in the control group. Methylprednisolone 197-215 interleukin 18 Homo sapiens 88-93 17827967-3 2007 In this study, we wanted to estimate the levels of CXCL11 chemokine and interleukin-18 (IL-18), a proinflammatory cytokine, in sera of relapsing-remitting MS (RRMS) patients, both before and after methylprednisolone (MP) treatment, and to compare the results with those in the control group. Methylprednisolone 217-219 interleukin 18 Homo sapiens 88-93 17224000-0 2007 Effects of rosiglitazone and metformin on inflammatory markers and adipokines: decrease in interleukin-18 is an independent factor for the improvement of homeostasis model assessment-beta in type 2 diabetes mellitus. Rosiglitazone 11-24 interleukin 18 Homo sapiens 91-105 17224000-0 2007 Effects of rosiglitazone and metformin on inflammatory markers and adipokines: decrease in interleukin-18 is an independent factor for the improvement of homeostasis model assessment-beta in type 2 diabetes mellitus. Metformin 29-38 interleukin 18 Homo sapiens 91-105 17224000-11 2007 Significant decreases in resistin, C-reactive protein, TNF-alpha, IL-6 and IL-18 were seen in the rosiglitazone-treated patients but not in the metformin-treated patients. Rosiglitazone 98-111 interleukin 18 Homo sapiens 75-80 17178383-7 2007 PTX-treated MDDCs which were induced to mature with LPS produced lower levels of TNF-alpha, IL-12 and IL-18 and higher levels of IL-10 than corresponding control MDDCs. Pentoxifylline 0-3 interleukin 18 Homo sapiens 102-107 17827967-0 2007 CXCL11 (Interferon-inducible T-cell alpha chemoattractant) and interleukin-18 in relapsing-remitting multiple sclerosis patients treated with methylprednisolone. Methylprednisolone 142-160 interleukin 18 Homo sapiens 63-77 17072982-12 2006 Incubation with ethanol reduced LPS-stimulated IL-18 secretion by about 50%. Ethanol 16-23 interleukin 18 Homo sapiens 47-52 17142727-7 2006 Human mast cell chymase rapidly cleaves recombinant pro-IL-18 at 56-phenylalanine and produces a biologically active IL-18 fragment that is smaller than any other reported IL-18-derived species. Phenylalanine 68-81 interleukin 18 Homo sapiens 56-61 18040815-4 2006 Furthermore, we found that corticosterone does not directly alter the intestinal barrier function; rather, it up-regulates interleukin-18, which then directly or indirectly contributes to impaired intestinal barrier function. Corticosterone 27-41 interleukin 18 Homo sapiens 123-137 17213584-5 2006 A linear regression between IL-18 and PGE2 was analysed. Dinoprostone 38-42 interleukin 18 Homo sapiens 28-33 17213584-8 2006 IL-18 was related with PGE2 in a linear curve fashion (the control group: r=0.76, P<0.001; the OA group: r=0.94, P<0.001). Dinoprostone 23-27 interleukin 18 Homo sapiens 0-5 17213584-10 2006 The increase of IL-18 might induce the increase of PGE2, and that might play an important role in OA pathogenesis. Dinoprostone 51-55 interleukin 18 Homo sapiens 16-21 16530440-0 2007 The effect of 4 weeks treatment with desloratadine (5mg daily) on levels of interleukin (IL)-4, IL-10, IL-18 and TGF beta in patients suffering from seasonal allergic rhinitis. desloratadine 37-50 interleukin 18 Homo sapiens 103-108 16438977-8 2006 IL-18 was also correlated with conventional risk factors including waist-hip ratio, BMI, blood pressure, triglycerides, HDL (inversely) and pack-years smoking (r(s) between 0.18 and 0.39, all P<0.001) but not with LDL-cholesterol. Triglycerides 105-118 interleukin 18 Homo sapiens 0-5 16438977-8 2006 IL-18 was also correlated with conventional risk factors including waist-hip ratio, BMI, blood pressure, triglycerides, HDL (inversely) and pack-years smoking (r(s) between 0.18 and 0.39, all P<0.001) but not with LDL-cholesterol. Cholesterol 221-232 interleukin 18 Homo sapiens 0-5 16966384-0 2006 Effect of nicotine on IL-18-initiated immune response in human monocytes. Nicotine 10-18 interleukin 18 Homo sapiens 22-27 16966384-4 2006 In the present study, we found that nicotine inhibited the IL-18-enhanced expression of ICAM-1, B7.2, and CD40 on monocytes, and the production of IL-12, IFN-gamma, and TNF-alpha by PBMC. Nicotine 36-44 interleukin 18 Homo sapiens 59-64 16894392-5 2006 The increased production of proinflammatory cytokines such as IL-1beta, TNF-alpha or IL-18 resulting from stroke may lead to an amplification of the inflammatory process, particularly in limbic areas, and widespread activation of indoleamine 2,3-dioxygenase (IDO) and subsequently to depletion of serotonin in paralimbic regions such as the ventral lateral frontal cortex, polar temporal cortex and basal ganglia. Serotonin 297-306 interleukin 18 Homo sapiens 85-90 17072982-13 2006 The mRNA expression of IL-18 in PBMC and the response of PBMC to ethanol and LPS was similar in CP patients and controls. Ethanol 65-72 interleukin 18 Homo sapiens 23-28 16837501-8 2006 In conclusion, thalidomide has the potential to improve the therapeutic regimens for sarcoidosis, hypersensitivity pneumonitis and idiopathic pulmonary fibrosis by reducing tumour necrosis factor-alpha, interleukin-12p40, interleukin-18 and interleukin-8 production. Thalidomide 15-26 interleukin 18 Homo sapiens 222-236 16837501-0 2006 Thalidomide reduces IL-18, IL-8 and TNF-alpha release from alveolar macrophages in interstitial lung disease. Thalidomide 0-11 interleukin 18 Homo sapiens 20-25 16405895-9 2006 In addition, IL-18 levels were significantly associated with other cardiovascular risk factors, namely age, low density lipoprotein (LDL) cholesterol, triglycerides, high density lipoprotein (HDL) cholesterol, insulin, proinsulin, body mass index (BMI), systolic and diastolic blood pressure. Cholesterol 138-149 interleukin 18 Homo sapiens 13-18 16405895-9 2006 In addition, IL-18 levels were significantly associated with other cardiovascular risk factors, namely age, low density lipoprotein (LDL) cholesterol, triglycerides, high density lipoprotein (HDL) cholesterol, insulin, proinsulin, body mass index (BMI), systolic and diastolic blood pressure. Triglycerides 151-164 interleukin 18 Homo sapiens 13-18 16405895-9 2006 In addition, IL-18 levels were significantly associated with other cardiovascular risk factors, namely age, low density lipoprotein (LDL) cholesterol, triglycerides, high density lipoprotein (HDL) cholesterol, insulin, proinsulin, body mass index (BMI), systolic and diastolic blood pressure. Cholesterol 197-208 interleukin 18 Homo sapiens 13-18 16837501-5 2006 In sarcoidosis and HP patients, thalidomide induced a dose-dependent, partial suppression of lipopolysacchride (LPS)-stimulated TNF-alpha, IL-12p40 and IL-18 release. Thalidomide 32-43 interleukin 18 Homo sapiens 152-157 17032165-4 2006 IL-18 reduces NK cell self-destruction during NK-targeted cell killing, and in the presence of staurosporin, a potent apoptotic inducer, IL-18 reduces caspase-3 activity. Staurosporine 95-107 interleukin 18 Homo sapiens 137-142 16837501-5 2006 In sarcoidosis and HP patients, thalidomide induced a dose-dependent, partial suppression of lipopolysacchride (LPS)-stimulated TNF-alpha, IL-12p40 and IL-18 release. lipopolysacchride 93-110 interleukin 18 Homo sapiens 152-157 16527878-7 2006 SLE patients with IL-18 concentration in the top tertile compared with the bottom tertile had significantly higher plasma levels of insulin, triglyceride, homocysteine and values of homeostasis model assessment insulin resistance (HOMA IR) and HOMA beta-cell. Triglycerides 141-153 interleukin 18 Homo sapiens 18-23 16527878-7 2006 SLE patients with IL-18 concentration in the top tertile compared with the bottom tertile had significantly higher plasma levels of insulin, triglyceride, homocysteine and values of homeostasis model assessment insulin resistance (HOMA IR) and HOMA beta-cell. Homocysteine 155-167 interleukin 18 Homo sapiens 18-23 16527878-8 2006 In addition, plasma concentrations of IL-18 correlated positively and significantly with BMI, insulin, HOMA IR, HOMA beta-cell, triglyceride, homocysteine, DBP and baPWV in all SLE patients. Triglycerides 128-140 interleukin 18 Homo sapiens 38-43 16527878-8 2006 In addition, plasma concentrations of IL-18 correlated positively and significantly with BMI, insulin, HOMA IR, HOMA beta-cell, triglyceride, homocysteine, DBP and baPWV in all SLE patients. Homocysteine 142-154 interleukin 18 Homo sapiens 38-43 16527878-8 2006 In addition, plasma concentrations of IL-18 correlated positively and significantly with BMI, insulin, HOMA IR, HOMA beta-cell, triglyceride, homocysteine, DBP and baPWV in all SLE patients. bapwv 164-169 interleukin 18 Homo sapiens 38-43 16650813-8 2006 IL-18-enhanced TSP-1 expression was blocked by SP600125, a c-Jun N-terminal kinase (JNK) specific inhibitor. pyrazolanthrone 47-55 interleukin 18 Homo sapiens 0-5 16836614-0 2006 Downregulation of human endometrial IL-18 by exogenous ovarian steroids. Steroids 63-71 interleukin 18 Homo sapiens 36-41 16836614-1 2006 PROBLEM: To evaluate the influence of ovarian steroids on IL-18, IL-15 and angiopoietin-2 mRNA expression in the endometrium in the mid luteal phase. Steroids 46-54 interleukin 18 Homo sapiens 58-63 16735695-3 2006 Previously, we found that pravastatin, fluvastatin, and simvastatin induced the production of IL-18 in human monocytes. Pravastatin 26-37 interleukin 18 Homo sapiens 94-99 16735695-3 2006 Previously, we found that pravastatin, fluvastatin, and simvastatin induced the production of IL-18 in human monocytes. Fluvastatin 39-50 interleukin 18 Homo sapiens 94-99 16735695-3 2006 Previously, we found that pravastatin, fluvastatin, and simvastatin induced the production of IL-18 in human monocytes. Simvastatin 56-67 interleukin 18 Homo sapiens 94-99 16735695-4 2006 The addition of mevalonate abolished the IL-18 production induced by pravastatin, fluvastatin, and simvastatin, indicating that the IL-18 production might be a result of the inhibition of HMG-CoA reductase. Mevalonic Acid 16-26 interleukin 18 Homo sapiens 41-46 16735695-4 2006 The addition of mevalonate abolished the IL-18 production induced by pravastatin, fluvastatin, and simvastatin, indicating that the IL-18 production might be a result of the inhibition of HMG-CoA reductase. Mevalonic Acid 16-26 interleukin 18 Homo sapiens 132-137 16735695-4 2006 The addition of mevalonate abolished the IL-18 production induced by pravastatin, fluvastatin, and simvastatin, indicating that the IL-18 production might be a result of the inhibition of HMG-CoA reductase. Pravastatin 69-80 interleukin 18 Homo sapiens 41-46 16735695-4 2006 The addition of mevalonate abolished the IL-18 production induced by pravastatin, fluvastatin, and simvastatin, indicating that the IL-18 production might be a result of the inhibition of HMG-CoA reductase. Fluvastatin 82-93 interleukin 18 Homo sapiens 41-46 16735695-4 2006 The addition of mevalonate abolished the IL-18 production induced by pravastatin, fluvastatin, and simvastatin, indicating that the IL-18 production might be a result of the inhibition of HMG-CoA reductase. Simvastatin 99-110 interleukin 18 Homo sapiens 41-46 16735695-4 2006 The addition of mevalonate abolished the IL-18 production induced by pravastatin, fluvastatin, and simvastatin, indicating that the IL-18 production might be a result of the inhibition of HMG-CoA reductase. Simvastatin 99-110 interleukin 18 Homo sapiens 132-137 16723495-5 2006 The PKA inhibitor H89 abolished the IL-18 production induced by cimetidine. Cimetidine 64-74 interleukin 18 Homo sapiens 36-41 16464907-11 2006 We conclude that TNF-induced insulin resistance of whole body glucose uptake is associated with increased IL-18 gene expression in muscle tissue, indicating that TNF and IL-18 interact, and both may have important regulatory roles in the pathogenesis of insulin resistance. Glucose 62-69 interleukin 18 Homo sapiens 106-111 16464907-11 2006 We conclude that TNF-induced insulin resistance of whole body glucose uptake is associated with increased IL-18 gene expression in muscle tissue, indicating that TNF and IL-18 interact, and both may have important regulatory roles in the pathogenesis of insulin resistance. Glucose 62-69 interleukin 18 Homo sapiens 170-175 16827865-7 2006 By multivariate analysis, both urine NGAL and IL-18 on day 0 predicted the trend in serum creatinine in the posttransplant period after adjusting for effects of age, gender, race, urine output and cold ischemia time (p < 0.01). Creatinine 90-100 interleukin 18 Homo sapiens 46-51 16842597-0 2006 UVB-induced interleukin-18 production is downregulated by tannic acids in human HaCaT keratinocytes. Tannins 58-70 interleukin 18 Homo sapiens 12-26 16723495-0 2006 Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes. Cimetidine 0-10 interleukin 18 Homo sapiens 19-33 16723495-3 2006 In fact, ranitidine and famotidine antagonized cimetidine-induced IL-18 production. Ranitidine 9-19 interleukin 18 Homo sapiens 66-71 16723495-3 2006 In fact, ranitidine and famotidine antagonized cimetidine-induced IL-18 production. Famotidine 24-34 interleukin 18 Homo sapiens 66-71 16723495-3 2006 In fact, ranitidine and famotidine antagonized cimetidine-induced IL-18 production. Cimetidine 47-57 interleukin 18 Homo sapiens 66-71 16723495-4 2006 Cimetidine induced the activation of caspase-1, which is reported to modify immature IL-18 to mature/active IL-18, and the elevation of intracellular cAMP, leading to the activation of protein kinase A (PKA). Cimetidine 0-10 interleukin 18 Homo sapiens 85-90 16723495-4 2006 Cimetidine induced the activation of caspase-1, which is reported to modify immature IL-18 to mature/active IL-18, and the elevation of intracellular cAMP, leading to the activation of protein kinase A (PKA). Cimetidine 0-10 interleukin 18 Homo sapiens 108-113 16723495-5 2006 The PKA inhibitor H89 abolished the IL-18 production induced by cimetidine. N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide 18-21 interleukin 18 Homo sapiens 36-41 17070508-4 2006 Incubation with the JNK inhibitor SP600125 inhibited the NKG2D expression induced by IL-2/IL-18 in the TGF-beta treated human NK cell line. pyrazolanthrone 34-42 interleukin 18 Homo sapiens 90-95 16515850-3 2006 Thus, biodegradable poly(D,L-lactide-co-glycolide) (PLGA) sustained-release microspheres for stereotaxic implantation loaded with interleukin-18 (IL-18), that is known to exert antitumour activity and trigger immune cell-mediated cytotoxicity, were developed. Polylactic Acid-Polyglycolic Acid Copolymer 20-50 interleukin 18 Homo sapiens 130-144 16019139-0 2006 Mitomycin C induces apoptosis via Fas/FasL dependent pathway and suppression of IL-18 in cervical carcinoma cells. Mitomycin 0-11 interleukin 18 Homo sapiens 80-85 16019139-6 2006 MMC treatment induced a reduction in the expressions of the E6 oncogene and IL-18, in a p53-independent manner. Mitomycin 0-3 interleukin 18 Homo sapiens 60-81 16554298-0 2006 Interleukin-18-induced human coronary artery smooth muscle cell migration is dependent on NF-kappaB- and AP-1-mediated matrix metalloproteinase-9 expression and is inhibited by atorvastatin. Atorvastatin 177-189 interleukin 18 Homo sapiens 0-14 16554298-11 2006 Atorvastatin effectively suppressed IL-18-mediated AP-1 and NF-kappaB activation, MMP9 expression, and SMC migration. Atorvastatin 0-12 interleukin 18 Homo sapiens 36-41 16554298-13 2006 Atorvastatin inhibits IL-18-mediated aortic SMC migration and has therapeutic potential for attenuating the progression of atherosclerosis and restenosis. Atorvastatin 0-12 interleukin 18 Homo sapiens 22-27 16019139-11 2006 These results suggest that MMC induces apoptosis, not only through caspase-8 and -3 dependent Fas/FasL pathway, but also via the regulation of NF-kappaB activity and IL-18 expression. Mitomycin 27-30 interleukin 18 Homo sapiens 166-171 16756729-7 2006 Multiple linear regression of delta values of IL-18 showed that only 2-hour glucose (P=0.008) remained independently and significantly associated with IL-18, whereas multiple linear regression analysis of delta values of MCP-1 revealed that only delta of HOMA-IR (P<0.001) remained independently and significantly associated with MCP-1, respectively. Glucose 76-83 interleukin 18 Homo sapiens 151-156 16515850-3 2006 Thus, biodegradable poly(D,L-lactide-co-glycolide) (PLGA) sustained-release microspheres for stereotaxic implantation loaded with interleukin-18 (IL-18), that is known to exert antitumour activity and trigger immune cell-mediated cytotoxicity, were developed. Polylactic Acid-Polyglycolic Acid Copolymer 20-50 interleukin 18 Homo sapiens 146-151 16611671-8 2006 In subjects with UA within the normal range, UA was significantly and independently associated with neutrophils count, C-reactive protein, IL-6, IL-1ra, IL-18, and TNF-alpha, whereas non-significant trends were observed for WBC (P=0.1) and sIL-6r (P=0.2). Uric Acid 45-47 interleukin 18 Homo sapiens 153-158 16621994-9 2006 We showed that simvastatin stimulates the secretion of IL-18 and IL-1beta in monocytes. Simvastatin 15-26 interleukin 18 Homo sapiens 55-60 16817867-5 2006 The results show that ChT, IL-16 and O2(-) levels significantly increased in ischemic CvD patients compared with AD patients and were significantly and positively correlated with IL-18 and O2(-). Oxygen 37-39 interleukin 18 Homo sapiens 179-184 16621994-10 2006 Active caspase-1, which is required for the processing and secretion of IL-18 and IL-1beta, was activated in simvastatin-treated monocytes. Simvastatin 109-120 interleukin 18 Homo sapiens 72-77 16458073-2 2006 Ciprofloxacin (CIP), which is useful for the clinical treatment of infections due to its antibacterial properties after transplantation, was shown to suppress the IFN-gamma and IL-12 production, the lymphocyte proliferation and the ICAM-1, B7.1, B7.2 and CD40 expression on monocytes during MLR in the presence of IL-18. Ciprofloxacin 0-13 interleukin 18 Homo sapiens 314-319 16516851-4 2006 The IL-18 production by monocytes stimulated without or with LPS or A23187+PMA for 1day was measured by ELISA. Tetradecanoylphorbol Acetate 75-78 interleukin 18 Homo sapiens 4-9 16516851-5 2006 The produced IL-18 spontaneously or in response to A23187+PMA by monocytes was significantly higher for volunteers with 105A/A genotype than with 105A/C genotype. Calcimycin 51-57 interleukin 18 Homo sapiens 13-18 16611188-0 2006 Modulation of the anti-inflammatory interleukin 10 and of proapoptotic IL-18 in patients with chronic hepatitis C treated with interferon alpha and ribavirin. Ribavirin 148-157 interleukin 18 Homo sapiens 71-76 16611188-10 2006 Treatment with interferon and ribavirin induced a significant decrease of IL-18 concentration independently of the viral response. Ribavirin 30-39 interleukin 18 Homo sapiens 74-79 16368150-10 2006 AP-1-specific inhibitor Curcumin dose-dependently abrogated the effect of IL-18 on VEGF production. Curcumin 24-32 interleukin 18 Homo sapiens 74-79 16441439-5 2006 We report that flagellin in pathophysiologically relevant concentrations augmented release of mature IL-18 by THP-1 monocytes, PBMC, and whole blood stimulated with nigericin or by ATP-mediated P2X7 purinergic receptor activation. Nigericin 165-174 interleukin 18 Homo sapiens 101-106 16517748-0 2006 Regulation of IL-1 family cytokines IL-1alpha, IL-1 receptor antagonist, and IL-18 by 1,25-dihydroxyvitamin D3 in primary keratinocytes. Calcitriol 86-110 interleukin 18 Homo sapiens 77-82 16517748-8 2006 The basal IL-18 expression and activity were much higher in VDR(-/-) keratinocytes and skin, underscoring the importance of the repressive role of vitamin D in IL-18 production. Vitamin D 147-156 interleukin 18 Homo sapiens 10-15 16517748-8 2006 The basal IL-18 expression and activity were much higher in VDR(-/-) keratinocytes and skin, underscoring the importance of the repressive role of vitamin D in IL-18 production. Vitamin D 147-156 interleukin 18 Homo sapiens 160-165 16517748-10 2006 Collectively, these results suggest that vitamin D modulates cutaneous inflammatory reactions, at least in part, by increasing the IL-1Ra to IL-1alpha ratio and suppressing IL-18 synthesis in keratinocytes. Vitamin D 41-50 interleukin 18 Homo sapiens 173-178 16433859-8 2006 Stratification of the asthma cases by skin reactivity to common allergens revealed an exclusive association of IL-18 -137 G-allele with an increased prevalence of atopic asthma (adjusted odds ratio (OR): 3.63; 95% confidence interval: (1.64-8.02) for GC or GG carriers vs. CC carriers), and no according association with asthma and concomitant negative skin reactivity (adjusted OR: 1.13; 0.66-1.94). gallocatechol 251-253 interleukin 18 Homo sapiens 111-116 16761500-3 2006 The aim of our study was to evaluate whether monotherapy with chloroquine phosphate affects IL-1beta, IL-6, IL-18 and TNF-alpha serum levels in SLE patients. chloroquine diphosphate 62-83 interleukin 18 Homo sapiens 108-113 16357479-6 2006 CONCLUSION: Plasma IL-18 concentration was significantly higher in HD patients and was significantly elevated by cellulose-based HD processes. Cellulose 113-122 interleukin 18 Homo sapiens 19-24 16873089-5 2006 The percentage change in ex vivo-induced level of inflammatory cytokine IL-18 was significantly lower in the TCM group than in the placebo group after taking the capsules for 24 weeks (p < 0.05). Chloroform 109-112 interleukin 18 Homo sapiens 72-77 16514436-6 2006 In vitro, IL-18 primed superoxide production by ANCA-activated neutrophils comparably to TNFalpha. Superoxides 23-33 interleukin 18 Homo sapiens 10-15 16514436-7 2006 IL-18-primed, ANCA-induced superoxide production was unaffected by anti-TNFalpha antibody, which abrogated TNFalpha priming. Superoxides 27-37 interleukin 18 Homo sapiens 0-5 16514436-9 2006 The p38 MAPK inhibitor, SB20358, reduced IL-18-primed, ANCA-induced superoxide production in a concentration-dependent manner. Ethyl 2-amino-5-Boc-6,7-dihydro-4H-thieno[3,2-c]pyridine-3-carboxylate 24-31 interleukin 18 Homo sapiens 41-46 16514436-9 2006 The p38 MAPK inhibitor, SB20358, reduced IL-18-primed, ANCA-induced superoxide production in a concentration-dependent manner. Superoxides 68-78 interleukin 18 Homo sapiens 41-46 16406656-0 2006 Plasma interleukin (IL)-18 (interferon-gamma-inducing factor) and other inflammatory cytokines in patients with gouty arthritis and monosodium urate monohydrate crystal-induced secretion of IL-18. Uric Acid 132-160 interleukin 18 Homo sapiens 7-26 16406656-0 2006 Plasma interleukin (IL)-18 (interferon-gamma-inducing factor) and other inflammatory cytokines in patients with gouty arthritis and monosodium urate monohydrate crystal-induced secretion of IL-18. Uric Acid 132-160 interleukin 18 Homo sapiens 190-195 16761500-7 2006 After three-months of chloroquine therapy the mean level of IL-6, IL-18 and TNF-alpha decreased significantly. Chloroquine 22-33 interleukin 18 Homo sapiens 66-71 16280246-0 2006 Interleukin-18 primes human basophilic KU812 cells for higher leukotriene synthesis. Leukotrienes 62-73 interleukin 18 Homo sapiens 0-14 17441364-8 2006 Serum creatinine correlated with IL-6, IL-18, TNFalpha, sTNFRII and hsCRP levels and serum urea-with TNFalpha, sTNFRII, IL-6 and IL-18. Creatinine 6-16 interleukin 18 Homo sapiens 39-44 16431290-11 2006 IL-18 level (before HSCT), in patients who received Busulfan and Fludarabin which were used to treat aGVHD, was lower than in patients who received Busulfan and Cyclophosphamide. Busulfan 52-60 interleukin 18 Homo sapiens 0-5 16431290-11 2006 IL-18 level (before HSCT), in patients who received Busulfan and Fludarabin which were used to treat aGVHD, was lower than in patients who received Busulfan and Cyclophosphamide. fludarabine 65-75 interleukin 18 Homo sapiens 0-5 16280246-7 2006 A23187stimulated LT-synthesis and IgE cross-linked LT-synthesis were enhanced after incubation with IL-3 or IL-18. a23187stimulated 0-16 interleukin 18 Homo sapiens 108-113 16317391-9 2005 IL-18 was attenuated by GLN at multiple time points post-CLP. Glutamine 24-27 interleukin 18 Homo sapiens 0-5 16299289-4 2005 The stimulation of DCs with MDP and FK565 in combination with lipid A, poly(I:C), and CpG DNA, but not with Pam3CSSNA, synergistically induced interleukin-12 (IL-12) p70 and gamma interferon (IFN-gamma), but not IL-18, in culture supernatants and induced IL-15 on the cell surface. heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine 36-41 interleukin 18 Homo sapiens 212-217 16306550-11 2005 Serum IL-18 levels also correlated positively with carotid IMT (r = 0.225, P = 0.042) and baPWV (r = 0.232, P = 0.040). bapwv 90-95 interleukin 18 Homo sapiens 6-11 16186395-3 2005 Elevated levels of IL-18 were associated with a significantly increased risk of type 2 diabetes after adjustment for age, sex, survey, BMI, systolic blood pressure, ratio of total cholesterol to HDL cholesterol, physical activity, alcohol intake, smoking status, and parental history of diabetes. Cholesterol 180-191 interleukin 18 Homo sapiens 19-24 15998544-3 2005 The selective beta2-AR agonists salbutamol and terbutaline induced a similar inhibitory pattern of IL-18 and IL-12 production. Albuterol 32-42 interleukin 18 Homo sapiens 99-104 15998544-3 2005 The selective beta2-AR agonists salbutamol and terbutaline induced a similar inhibitory pattern of IL-18 and IL-12 production. Terbutaline 47-58 interleukin 18 Homo sapiens 99-104 16100009-5 2005 We examined interleukin-18 promoter activity and mRNA and protein levels in the epithelial lining fluid of individuals with active sarcoidosis, and of individuals recovered from sarcoidosis, in response to purified protein derivative of Mycobacterium tuberculosis, beryllium sulfate, zirconium sulfate, aluminum sulfate, and lipopolysaccharide. beryllium sulfate 265-282 interleukin 18 Homo sapiens 12-26 16339124-8 2005 DISCUSSION: In summary, IL-18 serum concentrations are associated in apparently healthy humans with plasma concentrations of various LCTs. lcts 133-137 interleukin 18 Homo sapiens 24-29 16186395-3 2005 Elevated levels of IL-18 were associated with a significantly increased risk of type 2 diabetes after adjustment for age, sex, survey, BMI, systolic blood pressure, ratio of total cholesterol to HDL cholesterol, physical activity, alcohol intake, smoking status, and parental history of diabetes. Cholesterol 199-210 interleukin 18 Homo sapiens 19-24 16186395-3 2005 Elevated levels of IL-18 were associated with a significantly increased risk of type 2 diabetes after adjustment for age, sex, survey, BMI, systolic blood pressure, ratio of total cholesterol to HDL cholesterol, physical activity, alcohol intake, smoking status, and parental history of diabetes. Alcohols 231-238 interleukin 18 Homo sapiens 19-24 15936988-0 2005 Simvastatin induces interleukin-18 production in human peripheral blood mononuclear cells. Simvastatin 0-11 interleukin 18 Homo sapiens 20-34 16148039-9 2005 On multivariable analysis, urine IL-18 values predicted development of AKI 24 and 48 h later after adjustment for demographics, sepsis, Acute Physiologic Assessment and Chronic Health Evaluation (APACHE) III score, serum creatinine, and urine output. Creatinine 221-231 interleukin 18 Homo sapiens 33-38 16272137-7 2005 Epitope mapping analysis using two kinds of random peptide-displaying phage libraries and an IL-18 alanine mutant (D98A) demonstrated that the h18-108 scFv binds to the site 3 of IL-18, which is suggested to be an association site with the IL-18 receptor beta. Alanine 99-106 interleukin 18 Homo sapiens 179-184 16250265-0 2005 Effects of fluvastatin, an HMG-CoA reductase inhibitor, on serum levels of interleukin-18 and matrix metalloproteinase-9 in patients with hypercholesterolemia. Fluvastatin 11-22 interleukin 18 Homo sapiens 75-89 16250265-4 2005 METHODS: We investigated the effects of a 12-week therapy with fluvastatin on IL-18, MMP-9, and endothelial function in patients with hypercholesterolemia. Fluvastatin 63-74 interleukin 18 Homo sapiens 78-83 16250265-7 2005 CONCLUSIONS: Fluvastatin reduced plasma concentrations of IL-18 and MMP-9, and improved endothelial function in patients with hypercholesterolemia independent of its lipid-lowering effect. Fluvastatin 13-24 interleukin 18 Homo sapiens 58-63 15936988-3 2005 The IL-18 production is located upstream of the cytokine cascade activated by simvastatin. Simvastatin 78-89 interleukin 18 Homo sapiens 4-9 15936988-5 2005 In the presence of IL-18, simvastatin suppressed the expression of ICAM-1 and CD40 as well as the production of IL-12, TNF-alpha and IFN-gamma in PBMC, contributing to the anti-inflammatory effect of simvastatin. Simvastatin 26-37 interleukin 18 Homo sapiens 19-24 15936988-5 2005 In the presence of IL-18, simvastatin suppressed the expression of ICAM-1 and CD40 as well as the production of IL-12, TNF-alpha and IFN-gamma in PBMC, contributing to the anti-inflammatory effect of simvastatin. Simvastatin 200-211 interleukin 18 Homo sapiens 19-24 15936988-2 2005 Simvastatin, an HMG-CoA reductase inhibitor with mild inhibition of LFA-1, induced the production of interleukin (IL)-18, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma in human peripheral blood mononuclear cells (PBMC). Simvastatin 0-11 interleukin 18 Homo sapiens 101-120 16093612-0 2005 Nafamostat mesilate induces production of interleukin-12 and -18 in human peripheral blood mononuclear cells. nafamostat 0-19 interleukin 18 Homo sapiens 42-64 16052331-8 2005 IL-18 was more closely associated with postload glucose during an OGTT (p=0.04) rather than with fasting glucose (p=0.1). Glucose 48-55 interleukin 18 Homo sapiens 0-5 16154043-8 2005 Combinations of progesterone and betaHCG or estradiol respectively induced a significant decrease in production of IL-18 by mDC. Progesterone 16-28 interleukin 18 Homo sapiens 115-120 16154043-8 2005 Combinations of progesterone and betaHCG or estradiol respectively induced a significant decrease in production of IL-18 by mDC. Estradiol 44-53 interleukin 18 Homo sapiens 115-120 16048930-0 2005 Effect of ciprofloxacin-induced prostaglandin E2 on interleukin-18-treated monocytes. Ciprofloxacin 10-23 interleukin 18 Homo sapiens 52-66 16048930-0 2005 Effect of ciprofloxacin-induced prostaglandin E2 on interleukin-18-treated monocytes. Dinoprostone 32-48 interleukin 18 Homo sapiens 52-66 16048930-4 2005 In addition, ciprofloxacin suppressed the interleukin-18-induced production of tumor necrosis factor alpha, gamma interferon, and interleukin-12 in peripheral blood mononuclear cells by inhibiting the expression of intercellular adhesion molecule 1, B7.1, B7.2, and CD40 on monocytes, and this effect could be reversed by the addition of indomethacin or NS398. Ciprofloxacin 13-26 interleukin 18 Homo sapiens 42-56 16048930-4 2005 In addition, ciprofloxacin suppressed the interleukin-18-induced production of tumor necrosis factor alpha, gamma interferon, and interleukin-12 in peripheral blood mononuclear cells by inhibiting the expression of intercellular adhesion molecule 1, B7.1, B7.2, and CD40 on monocytes, and this effect could be reversed by the addition of indomethacin or NS398. Indomethacin 338-350 interleukin 18 Homo sapiens 42-56 16048930-4 2005 In addition, ciprofloxacin suppressed the interleukin-18-induced production of tumor necrosis factor alpha, gamma interferon, and interleukin-12 in peripheral blood mononuclear cells by inhibiting the expression of intercellular adhesion molecule 1, B7.1, B7.2, and CD40 on monocytes, and this effect could be reversed by the addition of indomethacin or NS398. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 354-359 interleukin 18 Homo sapiens 42-56 16048930-5 2005 These results indicate that ciprofloxacin exerts immunomodulatory activity via the production of prostaglandin E(2) and imply therapeutic potential of ciprofloxacin for the treatment of systemic inflammatory responses initiated by interleukin-18. Ciprofloxacin 28-41 interleukin 18 Homo sapiens 231-245 16048930-5 2005 These results indicate that ciprofloxacin exerts immunomodulatory activity via the production of prostaglandin E(2) and imply therapeutic potential of ciprofloxacin for the treatment of systemic inflammatory responses initiated by interleukin-18. Ciprofloxacin 151-164 interleukin 18 Homo sapiens 231-245 15963597-2 2005 COX-2 and its product, PGE2, play a role in hepatitis B and IL-18 has also been shown to inhibit HBV infection in vivo. Dinoprostone 23-27 interleukin 18 Homo sapiens 60-65 15963597-7 2005 PGE2 reversed the inhibition of LPS-induced IL-18 production by rHBsAg. Dinoprostone 0-4 interleukin 18 Homo sapiens 44-49 16061828-8 2005 After thyroxine withdrawal, serum levels of IL-18, sIL-2R and the percentage of NK cells decreased progressively. Thyroxine 6-15 interleukin 18 Homo sapiens 44-49 16093612-2 2005 We found that nafamostat mesilate elicits IL-12, IL-18, tumor necrosis factor-alpha and interferon-gamma production, and the expression of intercellular adhesion molecules-1, B7.1, B7.2, CD40, and CD40 ligand in human peripheral blood mononuclear cells. nafamostat 14-33 interleukin 18 Homo sapiens 49-54 15950732-1 2005 There are four cysteines (Cys74, Cys104, Cys112 and Cys163) in mature human IL-18 (hIL-18). Cysteine 15-24 interleukin 18 Homo sapiens 76-81 16002724-5 2005 IL-18 production fell with both AI and addition of S-nitroso-N-acetyl-d,l-penicillamine (a NO donor) but was not significantly increased by chemical NOS inhibition by l-N(5)-(1-iminoethyl)-ornithine. snap 51-87 interleukin 18 Homo sapiens 0-5 15972686-6 2005 We also showed that IL-18 controlled VEGF expression in vitro and also decreased CpG oligodeoxynucleotide induced VEGF-dependent neovascularization. Oligodeoxyribonucleotides 85-105 interleukin 18 Homo sapiens 20-25 15985261-3 2005 Prostaglandin E1 and E2 inhibited interleukin-18 production in human monocytes treated with lipopolysaccharide and prostanoid IP-, EP2- and EP4-receptor agonists mimicked the effects of prostaglandins E1 and E2. prostanoid ip 115-128 interleukin 18 Homo sapiens 34-48 15985261-4 2005 Therefore, prostanoid IP, EP2- and EP4-receptors might be involved in the decrease in interleukin-18 production during sepsis. prostanoid ip 11-24 interleukin 18 Homo sapiens 86-100 15950732-1 2005 There are four cysteines (Cys74, Cys104, Cys112 and Cys163) in mature human IL-18 (hIL-18). Cysteine 15-24 interleukin 18 Homo sapiens 83-89 15950732-2 2005 These cysteines are highly conserved in IL-18s of 11 species cloned so far, suggesting that one or more of the cysteines may be important for hIL-18 function. Cysteine 6-15 interleukin 18 Homo sapiens 142-148 15950732-2 2005 These cysteines are highly conserved in IL-18s of 11 species cloned so far, suggesting that one or more of the cysteines may be important for hIL-18 function. Cysteine 111-120 interleukin 18 Homo sapiens 142-148 16120577-5 2005 In the present study, a fusion protein, consisting of EGFR binding domain fused to human IL18 mature peptide via a linker peptide of (Gly4ser) 3, was constructed and expressed in the insect cell line Sf9 using Bac-to-Bac baculovirus expression system. gly4ser 134-141 interleukin 18 Homo sapiens 89-93 15870026-3 2005 In contrast, PGE1 inhibits all the adhesion molecule expression, cytokine production and T-cell proliferation in the presence of IL-18. Alprostadil 13-17 interleukin 18 Homo sapiens 129-134 15790931-5 2005 Serum IL-18 concentration measured in 955 subjects correlated with metabolic syndrome traits including body mass index (BMI), waist circumference, triglyceride, high-density lipoprotein (inversely), and fasting glucose and insulin levels (all P<0.001). Triglycerides 147-159 interleukin 18 Homo sapiens 6-11 15790931-5 2005 Serum IL-18 concentration measured in 955 subjects correlated with metabolic syndrome traits including body mass index (BMI), waist circumference, triglyceride, high-density lipoprotein (inversely), and fasting glucose and insulin levels (all P<0.001). Glucose 211-218 interleukin 18 Homo sapiens 6-11 15955140-8 2005 Serum levels of IL-18 in the patients with P-TB correlated well with the extent of disease. Terbium 45-47 interleukin 18 Homo sapiens 16-21 15760905-3 2005 We found that IL-18 and IL-18Ralpha bind to glycosylphosphatidylinositol (GPI) glycan via the third mannose 6-phosphate diester and the second beta-GlcNAc-deleted mannose 6-phosphate of GPI glycan, respectively. glycosylphosphatidylinositol (gpi) glycan 44-85 interleukin 18 Homo sapiens 14-19 15760905-3 2005 We found that IL-18 and IL-18Ralpha bind to glycosylphosphatidylinositol (GPI) glycan via the third mannose 6-phosphate diester and the second beta-GlcNAc-deleted mannose 6-phosphate of GPI glycan, respectively. mannose-6-phosphate 100-119 interleukin 18 Homo sapiens 14-19 15760905-3 2005 We found that IL-18 and IL-18Ralpha bind to glycosylphosphatidylinositol (GPI) glycan via the third mannose 6-phosphate diester and the second beta-GlcNAc-deleted mannose 6-phosphate of GPI glycan, respectively. Acetylglucosamine 143-154 interleukin 18 Homo sapiens 14-19 15760905-3 2005 We found that IL-18 and IL-18Ralpha bind to glycosylphosphatidylinositol (GPI) glycan via the third mannose 6-phosphate diester and the second beta-GlcNAc-deleted mannose 6-phosphate of GPI glycan, respectively. mannose-6-phosphate 163-182 interleukin 18 Homo sapiens 14-19 15760905-3 2005 We found that IL-18 and IL-18Ralpha bind to glycosylphosphatidylinositol (GPI) glycan via the third mannose 6-phosphate diester and the second beta-GlcNAc-deleted mannose 6-phosphate of GPI glycan, respectively. gpi glycan 186-196 interleukin 18 Homo sapiens 14-19 15760905-4 2005 To determine which GPI-anchored glycoprotein is involved in the complex of IL-18 and IL-18Ralpha, IL-18Ralpha of IL-18-stimulated KG-1 cells was immunoprecipitated together with CD48 by anti-IL-18Ralpha antibody. Glycosylphosphatidylinositols 19-22 interleukin 18 Homo sapiens 75-80 15760905-4 2005 To determine which GPI-anchored glycoprotein is involved in the complex of IL-18 and IL-18Ralpha, IL-18Ralpha of IL-18-stimulated KG-1 cells was immunoprecipitated together with CD48 by anti-IL-18Ralpha antibody. Glycosylphosphatidylinositols 19-22 interleukin 18 Homo sapiens 85-90 15760905-6 2005 To investigate whether the carbohydrate recognition of IL-18 is involved in physiological activities, KG-1 cells were digested with phosphatidylinositol-specific phospholipase C before IL-18 stimulation. Carbohydrates 27-39 interleukin 18 Homo sapiens 55-60 15760905-7 2005 Phosphatidylinositol-specific phospholipase C treatment inhibited the phosphorylation of tyrosine kinases and the following IL-18-dependent interferon-gamma production. Phosphatidylinositols 0-20 interleukin 18 Homo sapiens 124-129 15760905-9 2005 CD48 via both the peptide portion and GPI glycan triggers the binding to IL-18Rbeta, and the IL-18.IL-18Ralpha.CD48.IL-18Rbeta complex induces cellular signaling. gpi glycan 38-48 interleukin 18 Homo sapiens 73-78 15814163-5 2005 The results showed comparable responses of the patients treated with alendronate or risedronate, being a significant increase in BMD, an increase in circulating IL-18, and only slight modifications in circulating MMP-9 levels. Alendronate 69-80 interleukin 18 Homo sapiens 161-166 15814163-5 2005 The results showed comparable responses of the patients treated with alendronate or risedronate, being a significant increase in BMD, an increase in circulating IL-18, and only slight modifications in circulating MMP-9 levels. Risedronic Acid 84-95 interleukin 18 Homo sapiens 161-166 15814163-6 2005 After 12 months of treatment with raloxifene, there were minimal, non-significant increases in BMD, slight modifications in IL-18 levels, and a significant reduction in circulating MMP-9 levels. Raloxifene Hydrochloride 34-44 interleukin 18 Homo sapiens 124-129 15769913-0 2005 Clinical efficacy of infliximab plus methotrexate in DMARD naive and DMARD refractory rheumatoid arthritis is associated with decreased synovial expression of TNF alpha and IL18 but not CXCL12. Methotrexate 37-49 interleukin 18 Homo sapiens 173-177 15816475-0 2005 Up-regulation of IL-18 by interferon alpha-2b/ribavirin combination therapy induces an anti-viral effect in patients with chronic hepatitis C. BACKGROUND/AIMS: Recent large prospective trials demonstrated that the combination therapy of interferon (IFN)-alpha/ribavirin significantly increased a sustained virological response rate in patients with chronic hepatitis C. However, the potential mechanism of ribavirin is not clear. Ribavirin 46-55 interleukin 18 Homo sapiens 17-22 15816833-7 2005 In order to investigate whether the mitogen-activated protein kinase (MAPK) signaling pathway is involved in the downregulation of IL-18 production, cells were pre-treated with SB203580, an inhibitor of p38 MAPK, prior to the addition of CRH. SB 203580 177-185 interleukin 18 Homo sapiens 131-136 15753257-1 2005 Using flow cytometry, we observed that interleukin-18 (IL-18) primed human neutrophils (PMNs) in whole blood to produce superoxide anion (O2 degrees-) in response to N-formyl peptide (fMLP) stimulation, whereas IL-18 alone had no significant effect. Superoxides 120-136 interleukin 18 Homo sapiens 39-53 15753257-1 2005 Using flow cytometry, we observed that interleukin-18 (IL-18) primed human neutrophils (PMNs) in whole blood to produce superoxide anion (O2 degrees-) in response to N-formyl peptide (fMLP) stimulation, whereas IL-18 alone had no significant effect. Superoxides 120-136 interleukin 18 Homo sapiens 55-60 15753257-1 2005 Using flow cytometry, we observed that interleukin-18 (IL-18) primed human neutrophils (PMNs) in whole blood to produce superoxide anion (O2 degrees-) in response to N-formyl peptide (fMLP) stimulation, whereas IL-18 alone had no significant effect. n-formyl peptide 166-182 interleukin 18 Homo sapiens 39-53 15753257-1 2005 Using flow cytometry, we observed that interleukin-18 (IL-18) primed human neutrophils (PMNs) in whole blood to produce superoxide anion (O2 degrees-) in response to N-formyl peptide (fMLP) stimulation, whereas IL-18 alone had no significant effect. n-formyl peptide 166-182 interleukin 18 Homo sapiens 55-60 15753257-1 2005 Using flow cytometry, we observed that interleukin-18 (IL-18) primed human neutrophils (PMNs) in whole blood to produce superoxide anion (O2 degrees-) in response to N-formyl peptide (fMLP) stimulation, whereas IL-18 alone had no significant effect. n-formyl peptide 166-182 interleukin 18 Homo sapiens 211-216 15753257-5 2005 2,3-Butanedione 2-monoxime, which inhibits endosomal recycling of plasma membrane components back to the cell surface, concomitantly accentuated the diminution of fMLP binding at the PMN surface and increased IL-18 priming of O2 degrees- production by PMNs in response to fMLP. diacetylmonoxime 0-26 interleukin 18 Homo sapiens 209-214 15753257-7 2005 In addition, genistein, a tyrosine kinase inhibitor, and SB203580, a p38 mitogen-activated protein kinase (p38MAPK) inhibitor, completely reversed the decreased level of fMLP binding and increased the level of CD11b expression after IL-18 treatment. Genistein 13-22 interleukin 18 Homo sapiens 233-238 15753257-7 2005 In addition, genistein, a tyrosine kinase inhibitor, and SB203580, a p38 mitogen-activated protein kinase (p38MAPK) inhibitor, completely reversed the decreased level of fMLP binding and increased the level of CD11b expression after IL-18 treatment. SB 203580 57-65 interleukin 18 Homo sapiens 233-238 15753257-8 2005 Flow cytometric analysis of intact PMNs in whole blood showed that IL-18 increased p38MAPK phosphorylation and tyrosine phosphorylation. Tyrosine 111-119 interleukin 18 Homo sapiens 67-72 15799959-5 2005 The authors established a screening protocol using human peripheral blood mononuclear cells (PBMCs) and identified the hydrazino anthranilate compound 1 as a potent inhibitor of IL-12/IL-18-mediated IFN-gamma secretion from CD3(+) cells with an IC(50) around 200 nM. hydrazino anthranilate 119-141 interleukin 18 Homo sapiens 184-189 15799959-7 2005 Further work established that compound 1 was a potent intracellular iron chelator that inhibited both IL-12/IL-18- and IL-4-mediated T cell proliferation. Iron 68-72 interleukin 18 Homo sapiens 108-113 15799959-9 2005 Thus, the IL-12/IL-18-mediated proliferation and IFN-gamma secretion are very sensitive to intracellular iron concentration. Iron 105-109 interleukin 18 Homo sapiens 16-21 15618295-0 2005 Differential effect of LFA703, pravastatin, and fluvastatin on production of IL-18 and expression of ICAM-1 and CD40 in human monocytes. Pravastatin 31-42 interleukin 18 Homo sapiens 77-82 15618295-0 2005 Differential effect of LFA703, pravastatin, and fluvastatin on production of IL-18 and expression of ICAM-1 and CD40 in human monocytes. Fluvastatin 48-59 interleukin 18 Homo sapiens 77-82 15618295-2 2005 Pravastatin and fluvastatin also induced the production of IL-18, tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma) in human peripheral blood mononuclear cells (PBMC) in contrast to LFA703. Fluvastatin 16-27 interleukin 18 Homo sapiens 59-64 15618295-6 2005 In the presence of higher concentrations (5, 10, and 100 ng/ml) of IL-18, pravastatin, fluvastatin, and LFA703 similarly inhibited the expression of ICAM-1 and CD40 as well as the production of IL-12, TNF-alpha, and IFN-gamma in PBMC. Pravastatin 74-85 interleukin 18 Homo sapiens 67-72 15618295-1 2005 A novel, proinflammatory cytokine, interleukin (IL)-18 production was detected in the medium of human monocytes treated with 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase inhibitors, pravastatin, and fluvastatin (0.1 and 1 muM) but not with the statin-derived lymphocyte function-associated antigen-1 (LFA-1) inhibitor LFA703, which did not inhibit HMG-CoA reductase. 3-hydroxy-3-methylglutaryl 125-151 interleukin 18 Homo sapiens 35-54 15816475-0 2005 Up-regulation of IL-18 by interferon alpha-2b/ribavirin combination therapy induces an anti-viral effect in patients with chronic hepatitis C. BACKGROUND/AIMS: Recent large prospective trials demonstrated that the combination therapy of interferon (IFN)-alpha/ribavirin significantly increased a sustained virological response rate in patients with chronic hepatitis C. However, the potential mechanism of ribavirin is not clear. Ribavirin 260-269 interleukin 18 Homo sapiens 17-22 15618295-1 2005 A novel, proinflammatory cytokine, interleukin (IL)-18 production was detected in the medium of human monocytes treated with 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase inhibitors, pravastatin, and fluvastatin (0.1 and 1 muM) but not with the statin-derived lymphocyte function-associated antigen-1 (LFA-1) inhibitor LFA703, which did not inhibit HMG-CoA reductase. Pravastatin 195-206 interleukin 18 Homo sapiens 35-54 15618295-1 2005 A novel, proinflammatory cytokine, interleukin (IL)-18 production was detected in the medium of human monocytes treated with 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase inhibitors, pravastatin, and fluvastatin (0.1 and 1 muM) but not with the statin-derived lymphocyte function-associated antigen-1 (LFA-1) inhibitor LFA703, which did not inhibit HMG-CoA reductase. Fluvastatin 212-223 interleukin 18 Homo sapiens 35-54 15618295-6 2005 In the presence of higher concentrations (5, 10, and 100 ng/ml) of IL-18, pravastatin, fluvastatin, and LFA703 similarly inhibited the expression of ICAM-1 and CD40 as well as the production of IL-12, TNF-alpha, and IFN-gamma in PBMC. Fluvastatin 87-98 interleukin 18 Homo sapiens 67-72 15816475-0 2005 Up-regulation of IL-18 by interferon alpha-2b/ribavirin combination therapy induces an anti-viral effect in patients with chronic hepatitis C. BACKGROUND/AIMS: Recent large prospective trials demonstrated that the combination therapy of interferon (IFN)-alpha/ribavirin significantly increased a sustained virological response rate in patients with chronic hepatitis C. However, the potential mechanism of ribavirin is not clear. Ribavirin 260-269 interleukin 18 Homo sapiens 17-22 15816475-7 2005 CONCLUSIONS: This study suggests that ribavirin may contribute to the antiviral effect through up-regulation of IL-18 in combination with IFN in patients with chronic hepatitis C. Ribavirin 38-47 interleukin 18 Homo sapiens 112-117 15618295-1 2005 A novel, proinflammatory cytokine, interleukin (IL)-18 production was detected in the medium of human monocytes treated with 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase inhibitors, pravastatin, and fluvastatin (0.1 and 1 muM) but not with the statin-derived lymphocyte function-associated antigen-1 (LFA-1) inhibitor LFA703, which did not inhibit HMG-CoA reductase. LFA703 331-337 interleukin 18 Homo sapiens 35-54 15684607-3 2005 This analysis included the study of effects of chemotherapeutic drugs (5-fluorouracil [5-FU], gemcitabine, cisplatin) commonly used in the treatment of pancreatic cancer patients on IL-18 production and processing. Fluorouracil 71-85 interleukin 18 Homo sapiens 182-187 15618295-2 2005 Pravastatin and fluvastatin also induced the production of IL-18, tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma) in human peripheral blood mononuclear cells (PBMC) in contrast to LFA703. Pravastatin 0-11 interleukin 18 Homo sapiens 59-64 15574430-7 2005 Investigation into possible signal transduction pathways mediating IL-18 effects revealed that IL-18 activates phosphoinositide 3-kinase (PI3K), an effect that was blocked by wortmannin and LY-294002. Wortmannin 175-185 interleukin 18 Homo sapiens 67-72 15574430-7 2005 Investigation into possible signal transduction pathways mediating IL-18 effects revealed that IL-18 activates phosphoinositide 3-kinase (PI3K), an effect that was blocked by wortmannin and LY-294002. Wortmannin 175-185 interleukin 18 Homo sapiens 95-100 15574430-7 2005 Investigation into possible signal transduction pathways mediating IL-18 effects revealed that IL-18 activates phosphoinositide 3-kinase (PI3K), an effect that was blocked by wortmannin and LY-294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 190-199 interleukin 18 Homo sapiens 67-72 15574430-7 2005 Investigation into possible signal transduction pathways mediating IL-18 effects revealed that IL-18 activates phosphoinositide 3-kinase (PI3K), an effect that was blocked by wortmannin and LY-294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 190-199 interleukin 18 Homo sapiens 95-100 15684607-0 2005 Human pancreatic carcinoma cells secrete bioactive interleukin-18 after treatment with 5-fluorouracil: implications for anti-tumor immune response. Fluorouracil 87-101 interleukin 18 Homo sapiens 51-65 15684607-3 2005 This analysis included the study of effects of chemotherapeutic drugs (5-fluorouracil [5-FU], gemcitabine, cisplatin) commonly used in the treatment of pancreatic cancer patients on IL-18 production and processing. gemcitabine 94-105 interleukin 18 Homo sapiens 182-187 15684607-3 2005 This analysis included the study of effects of chemotherapeutic drugs (5-fluorouracil [5-FU], gemcitabine, cisplatin) commonly used in the treatment of pancreatic cancer patients on IL-18 production and processing. Cisplatin 107-116 interleukin 18 Homo sapiens 182-187 15684607-7 2005 However, the chemotherapeutic agent 5-FU, by inducing Caspase-1 and Caspase-3 activation, induced secretion of proteolytically processed mature and degraded IL-18 species, respectively, in Capan-2 cells. Fluorouracil 36-40 interleukin 18 Homo sapiens 157-162 15684607-8 2005 Conditioned medium from 5-FU-treated but not control Capan-2 cells induced IFN-gamma production by activated T cells in an IL-18-dependent manner. Fluorouracil 24-28 interleukin 18 Homo sapiens 123-128 15684607-9 2005 Furthermore, adjuvant polychemotherapy including 5-FU significantly increased serum levels of mature, bioactive IL-18 in pancreatic carcinoma patients. Fluorouracil 49-53 interleukin 18 Homo sapiens 112-117 15684607-10 2005 Treatment of pancreatic cancer cells with 5-FU induced Caspase-dependent processing of pro-IL18 leading to the secretion of biologically active IL-18. Fluorouracil 42-46 interleukin 18 Homo sapiens 144-149 15622543-3 2005 We hypothesized that two caspase-1-processed cytokines, interleukin (IL)-1beta and IL-18, are involved in oxygen-induced neuronal cell death. Oxygen 106-112 interleukin 18 Homo sapiens 83-88 16179748-0 2005 Homocysteine is positively associated with cytokine IL-18 plasma levels in coronary artery bypass surgery patients. Homocysteine 0-12 interleukin 18 Homo sapiens 52-57 16179748-1 2005 Homocysteine, cytokines (IL-18, IL-6, IL-8) are involved in vascular inflammation and coronary artery disease. Homocysteine 0-12 interleukin 18 Homo sapiens 25-30 16179748-2 2005 Homocysteine influences endothelial IL-6 and IL-8 cytokine expression and release, however, an association between homocysteine and IL-18 has not been previously investigated in endothelial/smooth muscle cells and or in coronary artery disease. Homocysteine 115-127 interleukin 18 Homo sapiens 132-137 16179748-3 2005 We report in 9 coronary artery bypass surgery (CABG) patients a positive correlation r = 0.86 between homocysteine and IL-18 plasma levels (p < 0.05). Homocysteine 102-114 interleukin 18 Homo sapiens 119-124 15280194-1 2004 Administration of exogenous interleukin-18 (IL-18) regulates experimental acute graft-versus-host disease (GVHD) in a Fas-dependent manner when donor CD4(+) T cells are required for mortality after experimental allogeneic bone marrow transplantation (BMT). ammonium ferrous sulfate 118-121 interleukin 18 Homo sapiens 28-42 15677863-4 2005 The IL-18 concentration negatively correlated with creatinine clearance (Ccr). Creatinine 51-61 interleukin 18 Homo sapiens 4-9 15614043-8 2005 Doxazosin, prazosin, and terazosin can induce monocyte activation with a specific pattern of expression of adhesion molecules and IL-18 production, and this may lead to T-cell activation through the cell-to-cell interaction. Doxazosin 0-9 interleukin 18 Homo sapiens 130-135 15614043-8 2005 Doxazosin, prazosin, and terazosin can induce monocyte activation with a specific pattern of expression of adhesion molecules and IL-18 production, and this may lead to T-cell activation through the cell-to-cell interaction. Prazosin 11-19 interleukin 18 Homo sapiens 130-135 15614043-8 2005 Doxazosin, prazosin, and terazosin can induce monocyte activation with a specific pattern of expression of adhesion molecules and IL-18 production, and this may lead to T-cell activation through the cell-to-cell interaction. Terazosin 25-34 interleukin 18 Homo sapiens 130-135 15614043-9 2005 The activation of T cells induced by the increase of the expression of ICAM-1 and CD40 and the production of IL-18 may be involved in the anti-cancer effects of doxazosin, prazosin, and terazosin. Doxazosin 161-170 interleukin 18 Homo sapiens 109-114 15614043-9 2005 The activation of T cells induced by the increase of the expression of ICAM-1 and CD40 and the production of IL-18 may be involved in the anti-cancer effects of doxazosin, prazosin, and terazosin. Prazosin 172-180 interleukin 18 Homo sapiens 109-114 15614043-9 2005 The activation of T cells induced by the increase of the expression of ICAM-1 and CD40 and the production of IL-18 may be involved in the anti-cancer effects of doxazosin, prazosin, and terazosin. Terazosin 186-195 interleukin 18 Homo sapiens 109-114 16358956-4 2005 The aim of our study was to estimate the serum levels of IL-18 and sICAM-1 in subjects with type 1 diabetes and their relatives, who share HLA diabetic susceptibility genes (with or without pancreatic autoantibodies), but still without glucose level disturbances, as an evaluation of the possible role of genetic predisposition to the presence of IL-18 in diabetic families. Glucose 236-243 interleukin 18 Homo sapiens 57-62 15593217-11 2004 Lipopolysaccharide- or lipoteichoic acid-mediated triggering of PBMCs incubated with IL-12/IL-18 or IFNgamma led to an increased production of both TNFalpha and IL-6, indicating the functionality of TLR-2 and TLR-4. lipoteichoic acid 23-40 interleukin 18 Homo sapiens 91-96 16141713-9 2005 PMX-F treatment reduced the plasma endotoxin and IL-18 levels significantly after the first treatment (p<0.05), after the second treatment (p<0.01), and on the following day (p<0.001). pmx-f 0-5 interleukin 18 Homo sapiens 49-54 16141713-11 2005 CONCLUSIONS: IL-18 may be associated with the severity of septic shock, and PMX-F treatment is effective in reducing the IL-18 level in patients with septic shock. pmx-f 76-81 interleukin 18 Homo sapiens 121-126 15614043-5 2005 Moreover, IL-18 was detected in the medium of incubated monocytes treated with doxazosin, prazosin, and terazosin. Doxazosin 79-88 interleukin 18 Homo sapiens 10-15 15614043-5 2005 Moreover, IL-18 was detected in the medium of incubated monocytes treated with doxazosin, prazosin, and terazosin. Prazosin 90-98 interleukin 18 Homo sapiens 10-15 15614043-5 2005 Moreover, IL-18 was detected in the medium of incubated monocytes treated with doxazosin, prazosin, and terazosin. Terazosin 104-113 interleukin 18 Homo sapiens 10-15 15614043-7 2005 Although caspase-1 inhibitor completely abolished the production of IL-18, anti-IL-18 mAb and caspase-1 inhibitor partially inhibited the increase in ICAM-1 and CD40 expression induced by doxazosin, prazosin, and terazosin. Doxazosin 188-197 interleukin 18 Homo sapiens 68-73 15614043-7 2005 Although caspase-1 inhibitor completely abolished the production of IL-18, anti-IL-18 mAb and caspase-1 inhibitor partially inhibited the increase in ICAM-1 and CD40 expression induced by doxazosin, prazosin, and terazosin. Doxazosin 188-197 interleukin 18 Homo sapiens 80-85 15614043-7 2005 Although caspase-1 inhibitor completely abolished the production of IL-18, anti-IL-18 mAb and caspase-1 inhibitor partially inhibited the increase in ICAM-1 and CD40 expression induced by doxazosin, prazosin, and terazosin. Prazosin 199-207 interleukin 18 Homo sapiens 68-73 15614043-7 2005 Although caspase-1 inhibitor completely abolished the production of IL-18, anti-IL-18 mAb and caspase-1 inhibitor partially inhibited the increase in ICAM-1 and CD40 expression induced by doxazosin, prazosin, and terazosin. Prazosin 199-207 interleukin 18 Homo sapiens 80-85 15614043-7 2005 Although caspase-1 inhibitor completely abolished the production of IL-18, anti-IL-18 mAb and caspase-1 inhibitor partially inhibited the increase in ICAM-1 and CD40 expression induced by doxazosin, prazosin, and terazosin. Terazosin 213-222 interleukin 18 Homo sapiens 68-73 15614043-7 2005 Although caspase-1 inhibitor completely abolished the production of IL-18, anti-IL-18 mAb and caspase-1 inhibitor partially inhibited the increase in ICAM-1 and CD40 expression induced by doxazosin, prazosin, and terazosin. Terazosin 213-222 interleukin 18 Homo sapiens 80-85 15183606-0 2004 The effect of the physical characteristics of hydroxyapatite particles on human monocytes IL-18 production in vitro. Durapatite 46-60 interleukin 18 Homo sapiens 90-95 15280194-1 2004 Administration of exogenous interleukin-18 (IL-18) regulates experimental acute graft-versus-host disease (GVHD) in a Fas-dependent manner when donor CD4(+) T cells are required for mortality after experimental allogeneic bone marrow transplantation (BMT). ammonium ferrous sulfate 118-121 interleukin 18 Homo sapiens 44-49 15306849-0 2004 P2X7 receptor polymorphism impairs extracellular adenosine 5"-triphosphate-induced interleukin-18 release from human monocytes. Adenosine Triphosphate 49-74 interleukin 18 Homo sapiens 83-97 15567770-4 2004 RESULT: In patients treated with risperidone, the levels of serum IL-6 and IL-2 after 4 weeks, TNFalpha after 8 weeks, and IL-18 after 6 months were all significantly lowered in comparison with the pretreatment levels (P<0.01 or 0.05). Risperidone 33-44 interleukin 18 Homo sapiens 123-128 15567770-5 2004 In clozapine group, the levels of IL-2 after 4 weeks and IL-6 and IL-18 after 6 months were lowered significantly (P<0.01 or 0.05). Clozapine 3-12 interleukin 18 Homo sapiens 66-71 15306849-1 2004 Interleukin (IL)-18 is an important proinflammatory cytokine processed and released from cells of the monocyte lineage by activation of the P2X(7) receptor by extracellular adenosine 5"-triphosphate (ATP). Adenosine Triphosphate 173-198 interleukin 18 Homo sapiens 0-19 15306849-1 2004 Interleukin (IL)-18 is an important proinflammatory cytokine processed and released from cells of the monocyte lineage by activation of the P2X(7) receptor by extracellular adenosine 5"-triphosphate (ATP). Adenosine Triphosphate 200-203 interleukin 18 Homo sapiens 0-19 15306849-3 2004 Using a whole blood-based assay, ATP-induced release of IL-18 from homozygous subjects after 120 min incubation with ATP was 42% of that from wild-type subjects. Adenosine Triphosphate 33-36 interleukin 18 Homo sapiens 56-61 15306849-3 2004 Using a whole blood-based assay, ATP-induced release of IL-18 from homozygous subjects after 120 min incubation with ATP was 42% of that from wild-type subjects. Adenosine Triphosphate 117-120 interleukin 18 Homo sapiens 56-61 15306849-4 2004 Moreover, the level of ATP-induced IL-18 release from lipopolysaccharide (LPS)-primed monocytes of homozygous subjects after 30 and 60 min incubation with ATP was 21 and 44%, respectively, of that from wild-type monocytes. Adenosine Triphosphate 23-26 interleukin 18 Homo sapiens 35-40 15306849-4 2004 Moreover, the level of ATP-induced IL-18 release from lipopolysaccharide (LPS)-primed monocytes of homozygous subjects after 30 and 60 min incubation with ATP was 21 and 44%, respectively, of that from wild-type monocytes. Adenosine Triphosphate 155-158 interleukin 18 Homo sapiens 35-40 15306849-5 2004 Nigericin, a K(+) ionophore, induced a similar release of IL-18 from monocytes of either genotype. Nigericin 0-9 interleukin 18 Homo sapiens 58-63 15555450-5 2004 FK506, CsA and DEX suppressed significantly the expressions of IL-18 mRNA and its protein (P<0.001) in LPS/PHA-stimulated whole blood cell from LN patients. Tacrolimus 0-5 interleukin 18 Homo sapiens 63-68 15482857-6 2004 The application of "M-I pair mutagenesis" and inclusion of a C-terminal arginine residue are then sufficient to solve this problem and convert one lead peptide into a functional complementary peptide mini-receptor inhibitor of IL-18. Arginine 72-80 interleukin 18 Homo sapiens 227-232 15555450-1 2004 AIM: To explore the expression of IL-18 in patients with active lupus nephritis(LN) and the inhibitory effects of immunosupressive agents FK506, cyclosporin A (CsA) and dexamethasone(DEX). Dextromethorphan 183-186 interleukin 18 Homo sapiens 34-39 15555450-5 2004 FK506, CsA and DEX suppressed significantly the expressions of IL-18 mRNA and its protein (P<0.001) in LPS/PHA-stimulated whole blood cell from LN patients. Cyclosporine 7-10 interleukin 18 Homo sapiens 63-68 15555450-5 2004 FK506, CsA and DEX suppressed significantly the expressions of IL-18 mRNA and its protein (P<0.001) in LPS/PHA-stimulated whole blood cell from LN patients. Dextromethorphan 15-18 interleukin 18 Homo sapiens 63-68 15555450-6 2004 The inhibitory effects of FK506, CsA and DEX on the IL-18 protein expression in LN patients were stronger than that in normal control group (P<0.01 or P<0.05). Tacrolimus 26-31 interleukin 18 Homo sapiens 52-57 15555450-6 2004 The inhibitory effects of FK506, CsA and DEX on the IL-18 protein expression in LN patients were stronger than that in normal control group (P<0.01 or P<0.05). Cyclosporine 33-36 interleukin 18 Homo sapiens 52-57 15555450-6 2004 The inhibitory effects of FK506, CsA and DEX on the IL-18 protein expression in LN patients were stronger than that in normal control group (P<0.01 or P<0.05). Dextromethorphan 41-44 interleukin 18 Homo sapiens 52-57 15320904-0 2004 Effect of tamoxifen on serum IL-18, vascular endothelial growth factor and nitric oxide activities in breast carcinoma patients. Tamoxifen 10-19 interleukin 18 Homo sapiens 29-34 15554077-10 2004 TAK-603 inhibited IL-12 production in stimulated blood monocytes of healthy subjects, whereas IL-18 was increased by treatment with TAK-603. TAK 603 132-139 interleukin 18 Homo sapiens 94-99 15554077-11 2004 TAK-603 inhibited IFN-gamma production in PHA-stimulated blood T lymphocytes of healthy subjects with stimulation of IL-12 or a combination of IL-12 and IL-18. TAK 603 0-7 interleukin 18 Homo sapiens 153-158 15320904-4 2004 In this study, we investigated the effect of tamoxifen therapy on serum VEGF, NO and IL-18 activity in breast cancer patients. Tamoxifen 45-54 interleukin 18 Homo sapiens 85-90 15320904-6 2004 Both serum VEGF and IL-18 levels decreased after tamoxifen therapy (P = 0.051, P < 0.05, respectively). Tamoxifen 49-58 interleukin 18 Homo sapiens 20-25 15320904-10 2004 The negative effect of tamoxifen therapy on IL-18, which is known to have a potent antitumour activity, may be related to the decreased tumour growth by induction of NO and reduction of VEGF activity as a feedback mechanism. Tamoxifen 23-32 interleukin 18 Homo sapiens 44-49 15345738-3 2004 Therefore, the purpose of this investigation was to evaluate the effects of megestrol acetate ingestion on circulating IL-15 and IL-18 concentrations in healthy elderly men. Megestrol Acetate 76-93 interleukin 18 Homo sapiens 129-134 15306590-6 2004 (2) T-bet expression of LPMCs stimulated by interleukin (IL)-12/IL-18 was analysed by western blotting. lpmcs 24-29 interleukin 18 Homo sapiens 64-69 15646011-4 2004 Correlation analyses showed that the serum IL-18 and TNF-alpha concentration were positively correlated with each other and positively with fasting plasma glucose (FPG), 2h postprandial glucose, glycosylated hemoglobin (HbA1c), triglyceride, and urinary albumin levels and negative correlation between TNF-alpha and high density lipoprotein cholesterol (HDL-C) were also found in diabetic subjects. Glucose 155-162 interleukin 18 Homo sapiens 43-48 15207779-0 2004 Histamine inhibits lipopolysaccharide-induced interleukin (IL)-18 production in human monocytes. Histamine 0-9 interleukin 18 Homo sapiens 46-65 15207779-3 2004 In the present study, we found that LPS at relatively high concentrations (10-1000 ng/ml) induced IL-18 production in a concentration-dependent manner both in monocytes isolated from PBMC, and that histamine (10(-7) to 10(-4) M) inhibited IL-18 production induced by LPS. Histamine 198-207 interleukin 18 Homo sapiens 98-103 15296730-1 2004 Caspase-1, a mediator of the posttranslational processing of IL-1beta and IL-18, requires an aspartic acid in the P1 position of its substrates. Aspartic Acid 93-106 interleukin 18 Homo sapiens 74-79 15646011-4 2004 Correlation analyses showed that the serum IL-18 and TNF-alpha concentration were positively correlated with each other and positively with fasting plasma glucose (FPG), 2h postprandial glucose, glycosylated hemoglobin (HbA1c), triglyceride, and urinary albumin levels and negative correlation between TNF-alpha and high density lipoprotein cholesterol (HDL-C) were also found in diabetic subjects. Deuterium 170-172 interleukin 18 Homo sapiens 43-48 15646011-4 2004 Correlation analyses showed that the serum IL-18 and TNF-alpha concentration were positively correlated with each other and positively with fasting plasma glucose (FPG), 2h postprandial glucose, glycosylated hemoglobin (HbA1c), triglyceride, and urinary albumin levels and negative correlation between TNF-alpha and high density lipoprotein cholesterol (HDL-C) were also found in diabetic subjects. Glucose 186-193 interleukin 18 Homo sapiens 43-48 15145612-1 2004 Endogenous catecholamine, epinephrine and norepinephrine, and isoproterenol concentration-dependently induced the production of interleukin (IL)-18, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma, and inhibited that of IL-10 in human peripheral blood mononuclear cells (PBMC). Catecholamines 11-24 interleukin 18 Homo sapiens 128-147 15646011-4 2004 Correlation analyses showed that the serum IL-18 and TNF-alpha concentration were positively correlated with each other and positively with fasting plasma glucose (FPG), 2h postprandial glucose, glycosylated hemoglobin (HbA1c), triglyceride, and urinary albumin levels and negative correlation between TNF-alpha and high density lipoprotein cholesterol (HDL-C) were also found in diabetic subjects. Triglycerides 228-240 interleukin 18 Homo sapiens 43-48 15646011-4 2004 Correlation analyses showed that the serum IL-18 and TNF-alpha concentration were positively correlated with each other and positively with fasting plasma glucose (FPG), 2h postprandial glucose, glycosylated hemoglobin (HbA1c), triglyceride, and urinary albumin levels and negative correlation between TNF-alpha and high density lipoprotein cholesterol (HDL-C) were also found in diabetic subjects. density lipoprotein cholesterol 321-352 interleukin 18 Homo sapiens 43-48 15161979-10 2004 Similarly, low levels of prostaglandin E2 were measured in IL-18-stimulated A549 cells and freshly obtained primary human monocytes and mouse macrophages. Dinoprostone 25-41 interleukin 18 Homo sapiens 59-64 15162350-3 2004 METHODS: The expression of IL-18 was analyzed by reverse transcriptase-polymerase chain reaction, Western blot, and ELISA in untreated and 5-fluorouracil (5-FU)-treated HNSCC cell lines. Fluorouracil 139-153 interleukin 18 Homo sapiens 27-32 15162350-3 2004 METHODS: The expression of IL-18 was analyzed by reverse transcriptase-polymerase chain reaction, Western blot, and ELISA in untreated and 5-fluorouracil (5-FU)-treated HNSCC cell lines. Fluorouracil 155-159 interleukin 18 Homo sapiens 27-32 15162350-7 2004 After exposure to 5-FU, the processed form of IL-18 was detected in the supernatants of both HNSCC cell lines. Fluorouracil 18-22 interleukin 18 Homo sapiens 46-51 15145612-6 2004 Epinephrine/norepinephrine/isoproterenol/beta 2-AR agonists increased the production of IL-18 in monocytes, but had no effect on IL-12, TNF-alpha, IFN-gamma and IL-10 production. Norepinephrine 12-26 interleukin 18 Homo sapiens 88-93 15145612-6 2004 Epinephrine/norepinephrine/isoproterenol/beta 2-AR agonists increased the production of IL-18 in monocytes, but had no effect on IL-12, TNF-alpha, IFN-gamma and IL-10 production. Isoproterenol 27-40 interleukin 18 Homo sapiens 88-93 15178407-2 2004 Our results indicate that isoproterenol (ISO) activates NF-kappaB DNA binding activity, and induces myocardial and systemic elaboration of IL-18 via beta2-AR signaling. Isoproterenol 26-39 interleukin 18 Homo sapiens 139-144 15178407-5 2004 In conclusion, our results indicate for the first time that isoproterenol induces myocardial and systemic elaboration of IL-18 via a beta2-AR and NF-kappaB-dependent mechanism. Isoproterenol 60-73 interleukin 18 Homo sapiens 121-126 15104599-6 2004 Using actinomycin D, we also showed that IL-18 mRNA is unstable in FLSs. Dactinomycin 6-19 interleukin 18 Homo sapiens 41-46 15145612-1 2004 Endogenous catecholamine, epinephrine and norepinephrine, and isoproterenol concentration-dependently induced the production of interleukin (IL)-18, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma, and inhibited that of IL-10 in human peripheral blood mononuclear cells (PBMC). Epinephrine 26-37 interleukin 18 Homo sapiens 128-147 15145612-1 2004 Endogenous catecholamine, epinephrine and norepinephrine, and isoproterenol concentration-dependently induced the production of interleukin (IL)-18, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma, and inhibited that of IL-10 in human peripheral blood mononuclear cells (PBMC). Norepinephrine 42-56 interleukin 18 Homo sapiens 128-147 15145612-1 2004 Endogenous catecholamine, epinephrine and norepinephrine, and isoproterenol concentration-dependently induced the production of interleukin (IL)-18, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma, and inhibited that of IL-10 in human peripheral blood mononuclear cells (PBMC). Isoproterenol 62-75 interleukin 18 Homo sapiens 128-147 15145612-5 2004 While endogenous IL-18 produced by salbutamol and terbutaline reached a sufficient concentration to induce IL-12 production, these beta 2-AR agonists did not induce the production of IL-12 at all. Albuterol 35-45 interleukin 18 Homo sapiens 17-22 15145612-5 2004 While endogenous IL-18 produced by salbutamol and terbutaline reached a sufficient concentration to induce IL-12 production, these beta 2-AR agonists did not induce the production of IL-12 at all. Terbutaline 50-61 interleukin 18 Homo sapiens 17-22 15145612-6 2004 Epinephrine/norepinephrine/isoproterenol/beta 2-AR agonists increased the production of IL-18 in monocytes, but had no effect on IL-12, TNF-alpha, IFN-gamma and IL-10 production. Epinephrine 0-11 interleukin 18 Homo sapiens 88-93 15317323-5 2004 Under staphylococcal enterotoxin B stimulation, IL-18 secretion was increased in peripheral blood mononuclear cells from patients with AD. Boron 33-34 interleukin 18 Homo sapiens 48-53 15047165-5 2004 Here we have generated a highly stable hIL-18 with replacement of cysteine by serine based on the tertiary structure and the binding mechanism, retaining the biological activity. Cysteine 66-74 interleukin 18 Homo sapiens 39-45 15202785-0 2004 Up-regulation of reactive oxygen species (ROS) and resistance to Fas-mediated apoptosis in the C33A cervical cancer cell line transfected with IL-18 receptor. Reactive Oxygen Species 17-40 interleukin 18 Homo sapiens 143-148 15202785-0 2004 Up-regulation of reactive oxygen species (ROS) and resistance to Fas-mediated apoptosis in the C33A cervical cancer cell line transfected with IL-18 receptor. Reactive Oxygen Species 42-45 interleukin 18 Homo sapiens 143-148 15202785-0 2004 Up-regulation of reactive oxygen species (ROS) and resistance to Fas-mediated apoptosis in the C33A cervical cancer cell line transfected with IL-18 receptor. ammonium ferrous sulfate 65-68 interleukin 18 Homo sapiens 143-148 15202785-2 2004 Transfection of the IL-18 receptor selectively induced a slight enhancement of the Fas via the up-regulation of intracellular reactive oxygen species and IL-18 in cervical carcinoma C33A cells, whereas there were no effects on the expression of p53, intercellular adhesion molecules-1 and Fas ligand. Reactive Oxygen Species 126-149 interleukin 18 Homo sapiens 20-25 15202785-4 2004 Thus, IL-18 receptor transfection induced IL-18 expression and enhanced intracellular reactive oxygen species and Fas expression in C33A cells in an interferon-gamma-independent pathway. Reactive Oxygen Species 86-109 interleukin 18 Homo sapiens 6-11 15202785-7 2004 Our results thus suggest that IL-18 and IL-18 receptor, together, may play a role in immunoregulation or in inflammation by augmenting the levels of IL-18 and reactive oxygen species in C33A cells. Reactive Oxygen Species 159-182 interleukin 18 Homo sapiens 30-35 15202785-7 2004 Our results thus suggest that IL-18 and IL-18 receptor, together, may play a role in immunoregulation or in inflammation by augmenting the levels of IL-18 and reactive oxygen species in C33A cells. Reactive Oxygen Species 159-182 interleukin 18 Homo sapiens 40-45 15202785-7 2004 Our results thus suggest that IL-18 and IL-18 receptor, together, may play a role in immunoregulation or in inflammation by augmenting the levels of IL-18 and reactive oxygen species in C33A cells. Reactive Oxygen Species 159-182 interleukin 18 Homo sapiens 40-45 15047165-5 2004 Here we have generated a highly stable hIL-18 with replacement of cysteine by serine based on the tertiary structure and the binding mechanism, retaining the biological activity. Serine 78-84 interleukin 18 Homo sapiens 39-45 14981598-5 2004 Median urinary IL-18 concentrations measured in the first 24 hours after kidney transplantation were 924 pg/mg creatinine (mean, 1,199 +/- 187 pg/mg creatinine) in patients who received a cadaveric kidney that developed delayed graft function compared with 171 pg/mg creatinine (mean, 367 +/- 102 pg/mg creatinine) in patients who received a cadaveric kidney with prompt graft function and 73 pg/mg creatinine (mean, 176 +/- 107 pg/mg creatinine) in patients who received a kidney with prompt graft function from a living donor (P <0.002). Creatinine 149-159 interleukin 18 Homo sapiens 15-20 15086491-3 2004 Reactive oxygen species (ROS) activate monocytes; therefore, a hemodialyzer with antioxidant activity would contrast ROS, prevent monocyte activation, reset IL-12 and IL-18 release, and restore Th1/Th2 balance. Reactive Oxygen Species 0-23 interleukin 18 Homo sapiens 167-172 15086491-3 2004 Reactive oxygen species (ROS) activate monocytes; therefore, a hemodialyzer with antioxidant activity would contrast ROS, prevent monocyte activation, reset IL-12 and IL-18 release, and restore Th1/Th2 balance. Reactive Oxygen Species 25-28 interleukin 18 Homo sapiens 167-172 14981598-5 2004 Median urinary IL-18 concentrations measured in the first 24 hours after kidney transplantation were 924 pg/mg creatinine (mean, 1,199 +/- 187 pg/mg creatinine) in patients who received a cadaveric kidney that developed delayed graft function compared with 171 pg/mg creatinine (mean, 367 +/- 102 pg/mg creatinine) in patients who received a cadaveric kidney with prompt graft function and 73 pg/mg creatinine (mean, 176 +/- 107 pg/mg creatinine) in patients who received a kidney with prompt graft function from a living donor (P <0.002). Creatinine 111-121 interleukin 18 Homo sapiens 15-20 15099362-8 2004 However, IL-18 mRNA expression was significantly different in the lesions of LP psoriasis in comparison with those of SP psoriasis. leucylproline 77-79 interleukin 18 Homo sapiens 9-14 14981598-5 2004 Median urinary IL-18 concentrations measured in the first 24 hours after kidney transplantation were 924 pg/mg creatinine (mean, 1,199 +/- 187 pg/mg creatinine) in patients who received a cadaveric kidney that developed delayed graft function compared with 171 pg/mg creatinine (mean, 367 +/- 102 pg/mg creatinine) in patients who received a cadaveric kidney with prompt graft function and 73 pg/mg creatinine (mean, 176 +/- 107 pg/mg creatinine) in patients who received a kidney with prompt graft function from a living donor (P <0.002). Creatinine 149-159 interleukin 18 Homo sapiens 15-20 14981598-5 2004 Median urinary IL-18 concentrations measured in the first 24 hours after kidney transplantation were 924 pg/mg creatinine (mean, 1,199 +/- 187 pg/mg creatinine) in patients who received a cadaveric kidney that developed delayed graft function compared with 171 pg/mg creatinine (mean, 367 +/- 102 pg/mg creatinine) in patients who received a cadaveric kidney with prompt graft function and 73 pg/mg creatinine (mean, 176 +/- 107 pg/mg creatinine) in patients who received a kidney with prompt graft function from a living donor (P <0.002). Creatinine 149-159 interleukin 18 Homo sapiens 15-20 14981598-5 2004 Median urinary IL-18 concentrations measured in the first 24 hours after kidney transplantation were 924 pg/mg creatinine (mean, 1,199 +/- 187 pg/mg creatinine) in patients who received a cadaveric kidney that developed delayed graft function compared with 171 pg/mg creatinine (mean, 367 +/- 102 pg/mg creatinine) in patients who received a cadaveric kidney with prompt graft function and 73 pg/mg creatinine (mean, 176 +/- 107 pg/mg creatinine) in patients who received a kidney with prompt graft function from a living donor (P <0.002). Creatinine 149-159 interleukin 18 Homo sapiens 15-20 14981598-5 2004 Median urinary IL-18 concentrations measured in the first 24 hours after kidney transplantation were 924 pg/mg creatinine (mean, 1,199 +/- 187 pg/mg creatinine) in patients who received a cadaveric kidney that developed delayed graft function compared with 171 pg/mg creatinine (mean, 367 +/- 102 pg/mg creatinine) in patients who received a cadaveric kidney with prompt graft function and 73 pg/mg creatinine (mean, 176 +/- 107 pg/mg creatinine) in patients who received a kidney with prompt graft function from a living donor (P <0.002). Creatinine 149-159 interleukin 18 Homo sapiens 15-20 14981598-6 2004 In kidney transplant recipients, lower urinary IL-18 levels were associated with a steeper decline in serum creatinine concentrations postoperative days 0 to 4 (P = 0.009). Creatinine 108-118 interleukin 18 Homo sapiens 47-52 14991611-3 2004 We have previously demonstrated that sodium butyrate, a bacterial fermentation product, induces IL-18 production via the proximal region of the promoter. Butyric Acid 37-52 interleukin 18 Homo sapiens 96-101 14993881-4 2004 Quantitative real-time polymerase chain reaction analysis revealed that perforin/granzyme B, TNF-alpha, and interleukin-18 messenger RNA (mRNA) levels in peripheral blood mononuclear cells from patients in whom autoGVHD developed were markedly higher (and temporally associated with the onset of autoaggression) compared with the levels detected in healthy individuals and in control, non-CsA-treated SCT patients. Cyclosporine 389-392 interleukin 18 Homo sapiens 108-122 14991611-4 2004 In this study we investigated the molecular mechanisms for basal and sodium butyrate-induced expression of IL-18 in human myeloid cells. Butyric Acid 69-84 interleukin 18 Homo sapiens 107-112 15162834-6 2004 RESULTS: IL-18 levels in supernatants of CBMC were low and did not vary significantly between unstimulated and PHA or BLG stimulated cell cultures (median 21.4; 23.5 and 15.5 pg/ml, respectively). cbmc 41-45 interleukin 18 Homo sapiens 9-14 15009430-9 2004 The ability of PGE2 to antagonize the potent inductive signal provided by the combination of IL-12 and IL-18 supports the concept that PGE2 may play an important role in limiting innate inflammatory processes in vivo through direct suppression of NK cell IFN-gamma synthesis. Dinoprostone 15-19 interleukin 18 Homo sapiens 103-108 15009430-9 2004 The ability of PGE2 to antagonize the potent inductive signal provided by the combination of IL-12 and IL-18 supports the concept that PGE2 may play an important role in limiting innate inflammatory processes in vivo through direct suppression of NK cell IFN-gamma synthesis. Dinoprostone 135-139 interleukin 18 Homo sapiens 103-108 15009430-0 2004 Prostaglandin E2 is a potent regulator of interleukin-12- and interleukin-18-induced natural killer cell interferon-gamma synthesis. Dinoprostone 0-16 interleukin 18 Homo sapiens 62-76 15009430-3 2004 Using homogeneous NK cell lines to establish direct effects, PGE2 (0.1-1 micro m) was found to suppress NK cell IFN-gamma synthesis and antagonized the potent synergistic IFN-gamma-inducing effects of IL-12 and IL-18. Dinoprostone 61-65 interleukin 18 Homo sapiens 211-216 15162834-8 2004 The addition of IL-18 to PHA or BLG stimulated CBMC significantly enhanced the IFN-gamma release (PHA: 6154; PHA + IL-18: 13474, p = 0.0001; BLG: 801; BLG + IL-18: 1077, p = 0.008). cbmc 47-51 interleukin 18 Homo sapiens 115-120 15162834-8 2004 The addition of IL-18 to PHA or BLG stimulated CBMC significantly enhanced the IFN-gamma release (PHA: 6154; PHA + IL-18: 13474, p = 0.0001; BLG: 801; BLG + IL-18: 1077, p = 0.008). cbmc 47-51 interleukin 18 Homo sapiens 115-120 15162834-8 2004 The addition of IL-18 to PHA or BLG stimulated CBMC significantly enhanced the IFN-gamma release (PHA: 6154; PHA + IL-18: 13474, p = 0.0001; BLG: 801; BLG + IL-18: 1077, p = 0.008). cbmc 47-51 interleukin 18 Homo sapiens 16-21 15162834-9 2004 In comparison to incubation without IL-18, the release of IL-13 was invariable or even reduced, when CBMC were stimulated with PHA + IL-18 (4026, p = 0.16) or BLG + IL-18 (124, p = 0.0001) compared to stimulation of CBMC with PHA (4357 pg/ml) or BLG (249 pg/ml) alone. cbmc 101-105 interleukin 18 Homo sapiens 133-138 15190610-2 2004 IL-18 induces synthesis and release of proinflammatory cytokines, chemokines and nitric oxide. Nitric Oxide 81-93 interleukin 18 Homo sapiens 0-5 14712306-11 2004 RT-PCR analysis revealed that CPA administration resulted in impaired mRNA production by peripheral blood mononuclear cells (PBMCs) of several cytokines (interferons alpha/beta, interferon gamma, TNFalpha, IL-15, and IL-18) with anti-HSV function. Cyclophosphamide 30-33 interleukin 18 Homo sapiens 217-222 14719133-11 2004 Incubation with ethanol alone did not affect basal IL-18 secretion, but ethanol reduced LPS-stimulated IL-18 secretion compared to LPS stimulation alone. Ethanol 16-23 interleukin 18 Homo sapiens 103-108 14719133-11 2004 Incubation with ethanol alone did not affect basal IL-18 secretion, but ethanol reduced LPS-stimulated IL-18 secretion compared to LPS stimulation alone. Ethanol 72-79 interleukin 18 Homo sapiens 103-108 14719133-12 2004 The mRNA expression of IL-18 in unstimulated PBMC and the response of PBMC to ethanol and LPS was similar in patients and controls. Ethanol 78-85 interleukin 18 Homo sapiens 23-28 15027313-6 2004 Furthermore, a positive correlation was observed between serum IL-18 concentration and serum Fas level in patients with RA (r = 0.472), whereas there was no significant correlation between serum IL-18 and sFas-ligand or other inflammatory markers (CRP, RF, CA-RF, IL-6, and IL-8). ammonium ferrous sulfate 93-96 interleukin 18 Homo sapiens 63-68 14979936-4 2004 RA-PBMCs activated with phytohemagglutinin and phorbol 12-myristate 13-acetate showed an increased sensitivity to IL-12 and IL-18, but still the RA-PBMC response was lower. Tetradecanoylphorbol Acetate 47-78 interleukin 18 Homo sapiens 124-129 15162834-9 2004 In comparison to incubation without IL-18, the release of IL-13 was invariable or even reduced, when CBMC were stimulated with PHA + IL-18 (4026, p = 0.16) or BLG + IL-18 (124, p = 0.0001) compared to stimulation of CBMC with PHA (4357 pg/ml) or BLG (249 pg/ml) alone. cbmc 101-105 interleukin 18 Homo sapiens 133-138 15162834-10 2004 CONCLUSIONS: IL-18 is detectable in supernatants of CBMC. cbmc 52-56 interleukin 18 Homo sapiens 13-18 15162834-12 2004 Based on our findings we conclude that IL-18 could act as a strong TH1-inducing factor on stimulated CBMC also in vivo. cbmc 101-105 interleukin 18 Homo sapiens 39-44 14872485-10 2004 NF-kappaB inhibitors N-acetyl-L-cysteine and Bay 11-7085 and PI 3-kinase inhibitor LY294002 inhibited the enhancing effects of IL-18, but MAPK p38 inhibitor SB203580, ERK inhibitor PD98059, and JNK inhibitor SP600125 did not. Acetylcysteine 21-40 interleukin 18 Homo sapiens 127-132 14872485-10 2004 NF-kappaB inhibitors N-acetyl-L-cysteine and Bay 11-7085 and PI 3-kinase inhibitor LY294002 inhibited the enhancing effects of IL-18, but MAPK p38 inhibitor SB203580, ERK inhibitor PD98059, and JNK inhibitor SP600125 did not. BAY 11-7085 45-56 interleukin 18 Homo sapiens 127-132 14872485-10 2004 NF-kappaB inhibitors N-acetyl-L-cysteine and Bay 11-7085 and PI 3-kinase inhibitor LY294002 inhibited the enhancing effects of IL-18, but MAPK p38 inhibitor SB203580, ERK inhibitor PD98059, and JNK inhibitor SP600125 did not. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 83-91 interleukin 18 Homo sapiens 127-132 14872485-10 2004 NF-kappaB inhibitors N-acetyl-L-cysteine and Bay 11-7085 and PI 3-kinase inhibitor LY294002 inhibited the enhancing effects of IL-18, but MAPK p38 inhibitor SB203580, ERK inhibitor PD98059, and JNK inhibitor SP600125 did not. SB 203580 157-165 interleukin 18 Homo sapiens 127-132 14872485-10 2004 NF-kappaB inhibitors N-acetyl-L-cysteine and Bay 11-7085 and PI 3-kinase inhibitor LY294002 inhibited the enhancing effects of IL-18, but MAPK p38 inhibitor SB203580, ERK inhibitor PD98059, and JNK inhibitor SP600125 did not. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 181-188 interleukin 18 Homo sapiens 127-132 14872485-10 2004 NF-kappaB inhibitors N-acetyl-L-cysteine and Bay 11-7085 and PI 3-kinase inhibitor LY294002 inhibited the enhancing effects of IL-18, but MAPK p38 inhibitor SB203580, ERK inhibitor PD98059, and JNK inhibitor SP600125 did not. pyrazolanthrone 208-216 interleukin 18 Homo sapiens 127-132 14764799-9 2004 Serum IL-18 levels correlated, after logarithmic transformation, with body mass index (r = 0.38; P < 0.0002), waist-to-hip ratio (r = 0.33; P < 0.001), and total testosterone levels (r = 0.24; P < 0.02), and inversely with the insulin sensitivity index (r = -0.23; P < 0.03). Testosterone 168-180 interleukin 18 Homo sapiens 6-11 14741428-5 2004 In contrast to its effects on IL-1alpha and IL-1beta secretion, BzATP induced TNF-alpha after LPS stimulation, but not after stimulation with Abeta(1-42), induced IL-18 secretion regardless of whether microglia were pre-activated and attenuated IL-6 secretion after either LPS or Abeta(1-42) pre-activation. BzATP 64-69 interleukin 18 Homo sapiens 163-168 14504095-9 2004 IL-18 might have a profound role during the initiation phase of an immune response by recruiting pre-DC2s and modulating the function of DC2s. dc2s 101-105 interleukin 18 Homo sapiens 0-5 14504095-9 2004 IL-18 might have a profound role during the initiation phase of an immune response by recruiting pre-DC2s and modulating the function of DC2s. dc2s 137-141 interleukin 18 Homo sapiens 0-5 14630085-3 2004 In the ECM invasion assay IL-18 significantly up-regulated transmigration of HL-60 cells, which in turn was inhibited by a synthetic MMP inhibitor: O-phenanthroline (o-PE), anti-MMP-9, anti-MMP-2 as well as anti-IL-18 monoclonal antibody (McAb), respectively, suggesting that induction of gelatinases by IL-18 leads to ECM degradation by these cells. 1,10-phenanthroline 148-164 interleukin 18 Homo sapiens 26-31 14630085-3 2004 In the ECM invasion assay IL-18 significantly up-regulated transmigration of HL-60 cells, which in turn was inhibited by a synthetic MMP inhibitor: O-phenanthroline (o-PE), anti-MMP-9, anti-MMP-2 as well as anti-IL-18 monoclonal antibody (McAb), respectively, suggesting that induction of gelatinases by IL-18 leads to ECM degradation by these cells. 1,10-phenanthroline 166-170 interleukin 18 Homo sapiens 26-31 14630085-3 2004 In the ECM invasion assay IL-18 significantly up-regulated transmigration of HL-60 cells, which in turn was inhibited by a synthetic MMP inhibitor: O-phenanthroline (o-PE), anti-MMP-9, anti-MMP-2 as well as anti-IL-18 monoclonal antibody (McAb), respectively, suggesting that induction of gelatinases by IL-18 leads to ECM degradation by these cells. Antibodies, Monoclonal 239-243 interleukin 18 Homo sapiens 26-31 12879265-4 2004 Here we report that cyclic adenosine monophosphate reduced and ionomycin increased IL-18 mRNA in RA synovial fibroblasts (SF) but not in OA SF. Ionomycin 63-72 interleukin 18 Homo sapiens 83-88 12879265-6 2004 Specific protein kinase C activator phorbol myristate acetate reduced transcription and secretion of IL-18 in RA SF and OA SF. Tetradecanoylphorbol Acetate 36-61 interleukin 18 Homo sapiens 101-106 12879265-7 2004 Staurosporine changed spontaneous IL-18 mRNA levels and increased the secretion of IL-18 protein. Staurosporine 0-13 interleukin 18 Homo sapiens 34-39 12879265-7 2004 Staurosporine changed spontaneous IL-18 mRNA levels and increased the secretion of IL-18 protein. Staurosporine 0-13 interleukin 18 Homo sapiens 83-88 14660039-3 2003 Here we report that 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine (KN-62), an inhibitor of ATP-mediated cellular activation by the purinoreceptor subtype P(2x7), potently suppresses interleukin-18 release from peripheral blood mononuclear cells. KN 62 20-93 interleukin 18 Homo sapiens 210-224 14660039-3 2003 Here we report that 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine (KN-62), an inhibitor of ATP-mediated cellular activation by the purinoreceptor subtype P(2x7), potently suppresses interleukin-18 release from peripheral blood mononuclear cells. KN 62 95-100 interleukin 18 Homo sapiens 210-224 14660039-0 2003 Inhibition of lipopolysaccharide/ATP-induced release of interleukin-18 by KN-62 and glyburide. Adenosine Triphosphate 33-36 interleukin 18 Homo sapiens 56-70 14660039-3 2003 Here we report that 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine (KN-62), an inhibitor of ATP-mediated cellular activation by the purinoreceptor subtype P(2x7), potently suppresses interleukin-18 release from peripheral blood mononuclear cells. Adenosine Triphosphate 119-122 interleukin 18 Homo sapiens 210-224 14660039-0 2003 Inhibition of lipopolysaccharide/ATP-induced release of interleukin-18 by KN-62 and glyburide. KN 62 74-79 interleukin 18 Homo sapiens 56-70 14660039-4 2003 Interleukin-18 liberation was likewise inhibited by glyburide, a modulator of ion transport and inhibitor of ATP-binding cassette transporter 1. Glyburide 52-61 interleukin 18 Homo sapiens 0-14 14660039-0 2003 Inhibition of lipopolysaccharide/ATP-induced release of interleukin-18 by KN-62 and glyburide. Glyburide 84-93 interleukin 18 Homo sapiens 56-70 14660039-1 2003 Monocytes release interleukin-18 after activation by lipopolysaccharide/ATP. Adenosine Triphosphate 72-75 interleukin 18 Homo sapiens 18-32 14660039-2 2003 Since inflammatory conditions such as sepsis are characterized by augmented interleukin-18 in sera of patients, we sought to modulate lipopolysaccharide/ATP-induced interleukin-18 release by pharmacological means. Adenosine Triphosphate 153-156 interleukin 18 Homo sapiens 165-179 14660039-5 2003 The data presented herein indicate that by pharmacologically interfering with the process of cytokine secretion agents such as KN-62 or glyburide have the potential to curb overproduction of interleukin-18 in septic patients. KN 62 127-132 interleukin 18 Homo sapiens 191-205 14660039-5 2003 The data presented herein indicate that by pharmacologically interfering with the process of cytokine secretion agents such as KN-62 or glyburide have the potential to curb overproduction of interleukin-18 in septic patients. Glyburide 136-145 interleukin 18 Homo sapiens 191-205 14668275-7 2003 After consumption of the high-carbohydrate, high-fiber meal, serum IL-18 concentrations decreased from baseline concentrations (P < 0.05) in both nondiabetic and diabetic subjects; adiponectin concentrations decreased after the high-carbohydrate, low-fiber meal in diabetic patients. Carbohydrates 30-42 interleukin 18 Homo sapiens 67-72 12934070-3 2003 We show that without LPS priming, nigericin alone triggered caspase-1 activation and IL-18 generation in THP-1 monocytic cells. Nigericin 34-43 interleukin 18 Homo sapiens 85-90 14561849-3 2003 Although interleukin (IL)-18 induced the expression of ICAM-1, B7.2, CD40, and CD40L, PGE1 prevented IL-18-induced expression of ICAM-1, B7.2, and CD40. Alprostadil 86-90 interleukin 18 Homo sapiens 101-106 14561849-8 2003 Moreover, PGE1 inhibited the production of IL-12 and interferon-gamma in PBMC in the presence and absence of IL-18, whereas PGE1 induced IL-10 production. Alprostadil 10-14 interleukin 18 Homo sapiens 109-114 14636438-0 2003 [Effects of N-acetylcysteine on serum IL-18 level in severe hepatitis patients]. Acetylcysteine 12-28 interleukin 18 Homo sapiens 38-43 12918059-4 2003 IFN-gamma produced in prostate cancers induced caspase-1 mRNA and IL-18 secretion of tumor cell lines, which was inhibited by the cell-permeable Tyr-Val-Ala-Asp-aldehyde caspase-1 inhibitor (YVAD-CHO). tyrosyl-valyl-alanyl-aspartal 145-169 interleukin 18 Homo sapiens 66-71 12918059-4 2003 IFN-gamma produced in prostate cancers induced caspase-1 mRNA and IL-18 secretion of tumor cell lines, which was inhibited by the cell-permeable Tyr-Val-Ala-Asp-aldehyde caspase-1 inhibitor (YVAD-CHO). tyrosyl-valyl-alanyl-aspartal 191-199 interleukin 18 Homo sapiens 66-71 12918059-7 2003 Exogenous IL-18 increased mitochondrial activity of both cell lines evaluated by the tetrazolium (MTT) assay but did not influence their proliferation. Tetrazolium Salts 85-96 interleukin 18 Homo sapiens 10-15 12918059-7 2003 Exogenous IL-18 increased mitochondrial activity of both cell lines evaluated by the tetrazolium (MTT) assay but did not influence their proliferation. monooxyethylene trimethylolpropane tristearate 98-101 interleukin 18 Homo sapiens 10-15 12934070-8 2003 Collectively, our study establishes a critical role for cathepsin B in nigericin-induced caspase-1-dependent IL-18 maturation and caspase-1-independent necrosis. Nigericin 71-80 interleukin 18 Homo sapiens 109-114 12804640-6 2003 By blocking the IL-18 loop using specific antisense oligodeoxynucleotide (ASON) for IL-18 mRNA or anti-human IL-18R monoclonal antibody (McAbR), we were not able to demonstrate a marked inhibition on the most leukemic cell lines growth. Oligodeoxyribonucleotides 52-72 interleukin 18 Homo sapiens 16-21 12941729-9 2003 Plasma tHcy concentrations were significantly higher in patients with high IL-18 than in those with normal IL-18. thcy 7-11 interleukin 18 Homo sapiens 75-80 12941729-9 2003 Plasma tHcy concentrations were significantly higher in patients with high IL-18 than in those with normal IL-18. thcy 7-11 interleukin 18 Homo sapiens 107-112 12941729-10 2003 Univariate and multivariate analyses showed a strong independent association between tHcy and IL-18. thcy 85-89 interleukin 18 Homo sapiens 94-99 12941729-13 2003 Plasma IL-18 is an independent determinant of plasma tHcy, which is linked independently with atherosclerotic carotid wall thickening. thcy 53-57 interleukin 18 Homo sapiens 7-12 14527086-3 2003 Somewhat paradoxically, IL-18 also has the capacity to induce allergic responses via induction of IL-4 production by T helper cells and to activate mast cells and basophils to release atopic effector molecules such as histamine. Histamine 218-227 interleukin 18 Homo sapiens 24-29 12804640-6 2003 By blocking the IL-18 loop using specific antisense oligodeoxynucleotide (ASON) for IL-18 mRNA or anti-human IL-18R monoclonal antibody (McAbR), we were not able to demonstrate a marked inhibition on the most leukemic cell lines growth. Oligodeoxyribonucleotides 52-72 interleukin 18 Homo sapiens 84-89 12804640-6 2003 By blocking the IL-18 loop using specific antisense oligodeoxynucleotide (ASON) for IL-18 mRNA or anti-human IL-18R monoclonal antibody (McAbR), we were not able to demonstrate a marked inhibition on the most leukemic cell lines growth. ason 74-78 interleukin 18 Homo sapiens 16-21 12804640-6 2003 By blocking the IL-18 loop using specific antisense oligodeoxynucleotide (ASON) for IL-18 mRNA or anti-human IL-18R monoclonal antibody (McAbR), we were not able to demonstrate a marked inhibition on the most leukemic cell lines growth. ason 74-78 interleukin 18 Homo sapiens 84-89 12874316-8 2003 The specific caspase-1 inhibitor Ac-YVAD-CMK blocked the early IL-18 release in AM infected with the virulent strain. ac-yvad 33-40 interleukin 18 Homo sapiens 63-68 12736393-4 2003 We examine the ability of GBS to induce the production of IFN-gamma, IL-18, and IL-12 by cord blood mixed mononuclear cells and compared these results with the IFN-gamma, IL-18, and IL-12 response of mixed mononuclear cells from adult blood. gbs 26-29 interleukin 18 Homo sapiens 69-74 12859727-9 2003 Immunohistochemical analysis revealed a significant increase of IL-18 production and CD11b+ macrophages but not CD4+ T cells in the inflamed mucosa in DSS-fed IL-18 Tg compared with DSS-fed WT mice. Dextran Sulfate 151-154 interleukin 18 Homo sapiens 64-69 12859727-9 2003 Immunohistochemical analysis revealed a significant increase of IL-18 production and CD11b+ macrophages but not CD4+ T cells in the inflamed mucosa in DSS-fed IL-18 Tg compared with DSS-fed WT mice. Dextran Sulfate 151-154 interleukin 18 Homo sapiens 159-164 12736393-5 2003 We demonstrate that cord blood mixed mononuclear cells produced significantly less IFN-gamma, IL-18, and IL-12 in response to GBS compared with mixed mononuclear cells from adults. gbs 126-129 interleukin 18 Homo sapiens 94-99 12736393-7 2003 The maximal cord blood cell production of IFN-gamma, in response to GBS, is achieved by priming the cells with both IL-18 and IL-12. gbs 68-71 interleukin 18 Homo sapiens 116-121 12842762-7 2003 Partial blocking of LEC apoptosis induced by IL-18 and TNF was observed when the cells were pretreated with the broad-spectrum inhibitor of caspases z-VAD-fmk, suggesting involvement of the caspase pathway in apoptosis induced by these cytokines in these cells. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 149-158 interleukin 18 Homo sapiens 45-50 12829919-7 2003 Whereas IL-18 significantly induced the expression of ICAM-1, B7.1, and B7.2 on monocytes in MLR and the production of interferon-gamma and IL-12, PGE2 inhibited these IL-18-initiated enhancements. Dinoprostone 147-151 interleukin 18 Homo sapiens 8-13 12829919-7 2003 Whereas IL-18 significantly induced the expression of ICAM-1, B7.1, and B7.2 on monocytes in MLR and the production of interferon-gamma and IL-12, PGE2 inhibited these IL-18-initiated enhancements. Dinoprostone 147-151 interleukin 18 Homo sapiens 168-173 12829919-10 2003 In the previous study, histamine inhibited ICAM-1 expression in the presence of IL-18 but had no effect in the absence of IL-18. Histamine 23-32 interleukin 18 Homo sapiens 80-85 12759891-4 2003 In addition, IL-18 levels were increased in diabetic patients with the development of urinary albumin excretion, with the highest found in those with microalbuminuria (<30 micro g/mg creatinine, 252.7 +/- 16.4 pg/mL; 30 to >300 micro g/mg creatinine, 352.7 +/- 35.2 pg/mL; >>300 micro g/mg creatinine, 350.0 +/- 16.0 pg/mL). Creatinine 186-196 interleukin 18 Homo sapiens 13-18 12773708-2 2003 Treatment of human peripheral blood mononuclear cells (PBMCs) with PG101 increased levels of TNF-alpha, IL-1beta, IL-10, and IL-12 by 100- to 1000-fold, whereas GM-CSF and IL-18 were activated by an order of magnitude. pg101 67-72 interleukin 18 Homo sapiens 172-177 12748489-7 2003 Administration of betamethasone (BMZ) and/or hydralazine (HYD) was significantly associated with a lower IL-18 compared with controls (159 +/- 50 pg/mL vs 224 +/- 75 pg/mL, P =.002). Betamethasone 18-31 interleukin 18 Homo sapiens 105-110 12748489-7 2003 Administration of betamethasone (BMZ) and/or hydralazine (HYD) was significantly associated with a lower IL-18 compared with controls (159 +/- 50 pg/mL vs 224 +/- 75 pg/mL, P =.002). 2-(2-hydroxy-phenyl)-1h-benzoimidazole-5-carboxamidine 33-36 interleukin 18 Homo sapiens 105-110 12748489-7 2003 Administration of betamethasone (BMZ) and/or hydralazine (HYD) was significantly associated with a lower IL-18 compared with controls (159 +/- 50 pg/mL vs 224 +/- 75 pg/mL, P =.002). Hydralazine 45-56 interleukin 18 Homo sapiens 105-110 12748489-10 2003 CONCLUSION: Lower IL-18 was associated with administration of either BMZ or HYD. 2-(2-hydroxy-phenyl)-1h-benzoimidazole-5-carboxamidine 69-72 interleukin 18 Homo sapiens 18-23 12759891-4 2003 In addition, IL-18 levels were increased in diabetic patients with the development of urinary albumin excretion, with the highest found in those with microalbuminuria (<30 micro g/mg creatinine, 252.7 +/- 16.4 pg/mL; 30 to >300 micro g/mg creatinine, 352.7 +/- 35.2 pg/mL; >>300 micro g/mg creatinine, 350.0 +/- 16.0 pg/mL). Creatinine 245-255 interleukin 18 Homo sapiens 13-18 12759891-4 2003 In addition, IL-18 levels were increased in diabetic patients with the development of urinary albumin excretion, with the highest found in those with microalbuminuria (<30 micro g/mg creatinine, 252.7 +/- 16.4 pg/mL; 30 to >300 micro g/mg creatinine, 352.7 +/- 35.2 pg/mL; >>300 micro g/mg creatinine, 350.0 +/- 16.0 pg/mL). Creatinine 245-255 interleukin 18 Homo sapiens 13-18 12552001-0 2003 Molluscum contagiosum virus interleukin-18 (IL-18) binding protein is secreted as a full-length form that binds cell surface glycosaminoglycans through the C-terminal tail and a furin-cleaved form with only the IL-18 binding domain. Glycosaminoglycans 125-143 interleukin 18 Homo sapiens 28-42 12775234-8 2003 By 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, IL-18 antisense oligodeoxynucleotides (ASON) clearly inhibited the growth of J6-1 and HL-60 cells (42% and 12% inhibited, respectively) in a dose-dependent manner. monooxyethylene trimethylolpropane tristearate 66-69 interleukin 18 Homo sapiens 78-83 12775234-8 2003 By 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, IL-18 antisense oligodeoxynucleotides (ASON) clearly inhibited the growth of J6-1 and HL-60 cells (42% and 12% inhibited, respectively) in a dose-dependent manner. Oligodeoxyribonucleotides 94-115 interleukin 18 Homo sapiens 78-83 12775234-8 2003 By 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, IL-18 antisense oligodeoxynucleotides (ASON) clearly inhibited the growth of J6-1 and HL-60 cells (42% and 12% inhibited, respectively) in a dose-dependent manner. ason 117-121 interleukin 18 Homo sapiens 78-83 12538816-3 2003 In the present study, we found that norepinephrine, epinephrine, or isoproterenol down-regulated IL-18 (100 ng/ml)-induced intercellular adhesion molecule (ICAM)-1 expression on monocytes in a dose-dependent manner (10(-8)-10(-4) M), but did not effect B7.1 and B7.2 expression after 24-h incubation. Norepinephrine 36-50 interleukin 18 Homo sapiens 97-102 12538816-3 2003 In the present study, we found that norepinephrine, epinephrine, or isoproterenol down-regulated IL-18 (100 ng/ml)-induced intercellular adhesion molecule (ICAM)-1 expression on monocytes in a dose-dependent manner (10(-8)-10(-4) M), but did not effect B7.1 and B7.2 expression after 24-h incubation. Epinephrine 39-50 interleukin 18 Homo sapiens 97-102 12538816-3 2003 In the present study, we found that norepinephrine, epinephrine, or isoproterenol down-regulated IL-18 (100 ng/ml)-induced intercellular adhesion molecule (ICAM)-1 expression on monocytes in a dose-dependent manner (10(-8)-10(-4) M), but did not effect B7.1 and B7.2 expression after 24-h incubation. Isoproterenol 68-81 interleukin 18 Homo sapiens 97-102 15155077-5 2003 RESULTS: A recombinant eukaryotic expression plasmid pcDNA3.1/hIL-18 was successfully constructed and expressed transiently in COS-7 cells and stably in Rlc310 cells. carbonyl sulfide 127-130 interleukin 18 Homo sapiens 62-68 12684057-0 2003 TNF-alpha and H2O2 induce IL-18 and IL-18R beta expression in cardiomyocytes via NF-kappa B activation. Hydrogen Peroxide 14-18 interleukin 18 Homo sapiens 26-31 12684057-5 2003 Both TNF-alpha and H(2)O(2) induced IL-18 mRNA and precursor protein in cardiomyocytes, and IL-18 release into culture supernatants. Hydrogen Peroxide 19-27 interleukin 18 Homo sapiens 36-41 12538816-6 2003 In the same manner, salbutanol and terbutaline as well as norepinephrine, epinephrine, and isoproterenol regulated the IL-18-induced cytokine production, including IL-12, tumor necrosis factor-alpha or interferon-gamma through the stimulation of beta 2-AR. Epinephrine 61-72 interleukin 18 Homo sapiens 119-124 12538816-6 2003 In the same manner, salbutanol and terbutaline as well as norepinephrine, epinephrine, and isoproterenol regulated the IL-18-induced cytokine production, including IL-12, tumor necrosis factor-alpha or interferon-gamma through the stimulation of beta 2-AR. Isoproterenol 91-104 interleukin 18 Homo sapiens 119-124 12552001-0 2003 Molluscum contagiosum virus interleukin-18 (IL-18) binding protein is secreted as a full-length form that binds cell surface glycosaminoglycans through the C-terminal tail and a furin-cleaved form with only the IL-18 binding domain. Glycosaminoglycans 125-143 interleukin 18 Homo sapiens 44-49 12387830-4 2002 The effect of UVB irradiation was blocked by antioxidant, N-acetyl-L-cysteine (NAC), which suggested the involvement of reactive oxygen intermediates (ROI) in the signal transduction of UVB irradiation-enhanced IL-18 synthesis. reactive oxygen 120-135 interleukin 18 Homo sapiens 211-216 12792151-0 2003 Relations of serum interleukin 18 levels to serum lipid and glucose concentrations in an apparently healthy adult population. Glucose 60-67 interleukin 18 Homo sapiens 19-33 12792151-1 2003 AIM: To investigate the associations between serum interleukin (IL) 18 concentrations and indices of lipid and carbohydrate metabolism in healthy adults. Carbohydrates 111-123 interleukin 18 Homo sapiens 51-70 12792151-3 2003 RESULTS: Univariate linear and partial regression analyses showed that the serum IL-18 concentration was positively correlated with serum triglyceride and glucose concentrations in both obese and diabetic subjects after controlling for the confounding effects of age, sex, and body mass index. Triglycerides 138-150 interleukin 18 Homo sapiens 81-86 12792151-3 2003 RESULTS: Univariate linear and partial regression analyses showed that the serum IL-18 concentration was positively correlated with serum triglyceride and glucose concentrations in both obese and diabetic subjects after controlling for the confounding effects of age, sex, and body mass index. Glucose 155-162 interleukin 18 Homo sapiens 81-86 12792151-4 2003 CONCLUSION: IL-18 may be associated with obesity and glucose intolerance. Glucose 53-60 interleukin 18 Homo sapiens 12-17 12538816-5 2003 beta 2-AR-selective agonists salbutanol and terbutaline down-regulated IL-18-induced ICAM-1 expression on monocytes, but alpha 1-, alpha 2-, or beta1-AR agonist had no effect. salbutanol 29-39 interleukin 18 Homo sapiens 71-76 12538816-5 2003 beta 2-AR-selective agonists salbutanol and terbutaline down-regulated IL-18-induced ICAM-1 expression on monocytes, but alpha 1-, alpha 2-, or beta1-AR agonist had no effect. Terbutaline 44-55 interleukin 18 Homo sapiens 71-76 12538816-6 2003 In the same manner, salbutanol and terbutaline as well as norepinephrine, epinephrine, and isoproterenol regulated the IL-18-induced cytokine production, including IL-12, tumor necrosis factor-alpha or interferon-gamma through the stimulation of beta 2-AR. salbutanol 20-30 interleukin 18 Homo sapiens 119-124 12538816-6 2003 In the same manner, salbutanol and terbutaline as well as norepinephrine, epinephrine, and isoproterenol regulated the IL-18-induced cytokine production, including IL-12, tumor necrosis factor-alpha or interferon-gamma through the stimulation of beta 2-AR. Terbutaline 35-46 interleukin 18 Homo sapiens 119-124 12538816-6 2003 In the same manner, salbutanol and terbutaline as well as norepinephrine, epinephrine, and isoproterenol regulated the IL-18-induced cytokine production, including IL-12, tumor necrosis factor-alpha or interferon-gamma through the stimulation of beta 2-AR. Norepinephrine 58-72 interleukin 18 Homo sapiens 119-124 12390326-4 2002 Plasma IL-18 and NO concentrations were significantly higher in RSLE than NC (both P < 0.01). rsle 64-68 interleukin 18 Homo sapiens 7-12 12390326-5 2002 Elevation of plasma IL-18 in RSLE correlated positively and significantly with SLE -disease activity index and plasma NO concentration (r = 0.623, P < 0.0001 and r = 0.455, P = 0.017, respectively), and the latter also showed a positive and significant correlation with plasma creatinine (r = 0.410, P = 0.034) and urea (r = 0.685, P < 0.0001). Creatinine 280-290 interleukin 18 Homo sapiens 20-25 12390326-5 2002 Elevation of plasma IL-18 in RSLE correlated positively and significantly with SLE -disease activity index and plasma NO concentration (r = 0.623, P < 0.0001 and r = 0.455, P = 0.017, respectively), and the latter also showed a positive and significant correlation with plasma creatinine (r = 0.410, P = 0.034) and urea (r = 0.685, P < 0.0001). Urea 318-322 interleukin 18 Homo sapiens 20-25 12387830-6 2002 Furthermore, inhibitors of UVB-induced AP-1 activity, such as PD98059, blocked enhanced IL-18 production, indicating that AP-1 activation is required for UVB-induced IL-18 production. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 62-69 interleukin 18 Homo sapiens 88-93 12387830-6 2002 Furthermore, inhibitors of UVB-induced AP-1 activity, such as PD98059, blocked enhanced IL-18 production, indicating that AP-1 activation is required for UVB-induced IL-18 production. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 62-69 interleukin 18 Homo sapiens 166-171 12105209-3 2002 Using phosphoinositide 3-kinase (PI3-kinase) inhibitor LY294002 and Src inhibitor PP2, we show that interleukin (IL)-18-induced ERK1/2 activation is Src kinase-dependent. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 55-63 interleukin 18 Homo sapiens 100-119 12379575-2 2002 We assessed the role of glucose in the regulation of circulating levels of IL-6, TNF-alpha, and interleukin-18 (IL-18) in subjects with normal or impaired glucose tolerance (IGT), as well as the effect of the antioxidant glutathione. Glucose 24-31 interleukin 18 Homo sapiens 96-110 12381835-5 2002 IL-1F7b shares two conserved amino acids with IL-18 (Glu-35 and Lys-124), which participate in the interaction of IL-18 with the IL-18Ralpha chain as well as the IL-18-binding protein (IL-18BP), a secreted protein that neutralizes IL-18 activity. Glutamic Acid 53-56 interleukin 18 Homo sapiens 46-51 12381835-5 2002 IL-1F7b shares two conserved amino acids with IL-18 (Glu-35 and Lys-124), which participate in the interaction of IL-18 with the IL-18Ralpha chain as well as the IL-18-binding protein (IL-18BP), a secreted protein that neutralizes IL-18 activity. Glutamic Acid 53-56 interleukin 18 Homo sapiens 114-119 12381835-5 2002 IL-1F7b shares two conserved amino acids with IL-18 (Glu-35 and Lys-124), which participate in the interaction of IL-18 with the IL-18Ralpha chain as well as the IL-18-binding protein (IL-18BP), a secreted protein that neutralizes IL-18 activity. Glutamic Acid 53-56 interleukin 18 Homo sapiens 114-119 12381835-5 2002 IL-1F7b shares two conserved amino acids with IL-18 (Glu-35 and Lys-124), which participate in the interaction of IL-18 with the IL-18Ralpha chain as well as the IL-18-binding protein (IL-18BP), a secreted protein that neutralizes IL-18 activity. Lysine 64-67 interleukin 18 Homo sapiens 46-51 12381835-5 2002 IL-1F7b shares two conserved amino acids with IL-18 (Glu-35 and Lys-124), which participate in the interaction of IL-18 with the IL-18Ralpha chain as well as the IL-18-binding protein (IL-18BP), a secreted protein that neutralizes IL-18 activity. Lysine 64-67 interleukin 18 Homo sapiens 114-119 12381835-5 2002 IL-1F7b shares two conserved amino acids with IL-18 (Glu-35 and Lys-124), which participate in the interaction of IL-18 with the IL-18Ralpha chain as well as the IL-18-binding protein (IL-18BP), a secreted protein that neutralizes IL-18 activity. Lysine 64-67 interleukin 18 Homo sapiens 114-119 12364868-0 2002 Effect of histamine on intercellular adhesion molecule-1 expression and production of interferon-gamma and interleukin-12 in mixed lymphocyte reaction stimulated with interleukin-18. Histamine 10-19 interleukin 18 Homo sapiens 167-181 12364868-4 2002 We also investigated the modulatory effects of histamine on IL-18 action because histamine has been demonstrated to be a modulator of IL-18 effect and a mediator of inflammation. Histamine 81-90 interleukin 18 Homo sapiens 134-139 12364868-9 2002 Histamine concentration-dependently inhibited ICAM-1 expression and cytokine production in MLR stimulated with IL-18, whereas histamine alone did not show any effects on these responses in the absence of IL-18. Histamine 0-9 interleukin 18 Homo sapiens 111-116 12364868-12 2002 The fact that histamine could inhibit the IL-18-stimulated MLR implies that immunomodulation by histamine and selective H2-receptor agonists may have an important role in future immunosuppressive strategies. Histamine 14-23 interleukin 18 Homo sapiens 42-47 12364868-12 2002 The fact that histamine could inhibit the IL-18-stimulated MLR implies that immunomodulation by histamine and selective H2-receptor agonists may have an important role in future immunosuppressive strategies. Histamine 96-105 interleukin 18 Homo sapiens 42-47 12105209-4 2002 Antisense (AS) c-Src oligonucleotide (ODN) treatment reduced IL-18-induced ERK1/2 expression by 32% compared with control, suggesting an upstream role of Src in ERK1/2 activation. Oligonucleotides 21-36 interleukin 18 Homo sapiens 61-66 12105209-4 2002 Antisense (AS) c-Src oligonucleotide (ODN) treatment reduced IL-18-induced ERK1/2 expression by 32% compared with control, suggesting an upstream role of Src in ERK1/2 activation. odn 38-41 interleukin 18 Homo sapiens 61-66 12426765-0 2002 A Japanese case of severe refractory adult Still"s disease: serum interleukin-18 is a possible marker of the response to low-dose cyclosporin A therapy. Cyclosporine 130-143 interleukin 18 Homo sapiens 66-80 12207348-0 2002 Enhanced production of IL-18 in butyrate-treated intestinal epithelium by stimulation of the proximal promoter region. Butyrates 32-40 interleukin 18 Homo sapiens 23-28 12207348-4 2002 We investigated the effect of SCFA (butyrate, propionate, acetate) on expression of IL-18 in IEC in vitro and in vivo. Fatty Acids, Volatile 30-34 interleukin 18 Homo sapiens 84-89 12207348-4 2002 We investigated the effect of SCFA (butyrate, propionate, acetate) on expression of IL-18 in IEC in vitro and in vivo. Butyrates 36-44 interleukin 18 Homo sapiens 84-89 12207348-4 2002 We investigated the effect of SCFA (butyrate, propionate, acetate) on expression of IL-18 in IEC in vitro and in vivo. Propionates 46-56 interleukin 18 Homo sapiens 84-89 12207348-4 2002 We investigated the effect of SCFA (butyrate, propionate, acetate) on expression of IL-18 in IEC in vitro and in vivo. Acetates 58-65 interleukin 18 Homo sapiens 84-89 12207348-9 2002 Butyrate and acetate increased intracellular IL-18 content in a time- and dose-dependent fashion. Butyrates 0-8 interleukin 18 Homo sapiens 45-50 12207348-9 2002 Butyrate and acetate increased intracellular IL-18 content in a time- and dose-dependent fashion. Acetates 13-20 interleukin 18 Homo sapiens 45-50 12207348-10 2002 In contrast to proinflammatory stimuli butyrate potently activated the IL-18 promoter, indicating that IL-18 is regulated at the transcriptional level by SCFA. Butyrates 39-47 interleukin 18 Homo sapiens 71-76 12207348-11 2002 Furthermore, a 108-bp sequence in the proximal region was identified to be essential for IL-18 promoter activation by butyrate. Butyrates 118-126 interleukin 18 Homo sapiens 89-94 12426765-5 2002 The serum interleukin-18 level was monitored throughout treatment and was found to be a potentially useful marker of disease activity as well as of the response to cyclosporin A therapy. Cyclosporine 164-177 interleukin 18 Homo sapiens 10-24 12147250-3 2002 In DCs, lipopolysaccharide (LPS)-induced production of tumor necrosis factor-alpha (TNF-alpha), interleukin-(IL)-1alpha, IL-10, IL-12, and IL-18 was significantly inhibited by captopril. Captopril 176-185 interleukin 18 Homo sapiens 139-144 12365719-0 2002 Prednisolone induces interleukin-18 expression in mononuclear blood and myeloid progenitor cells. Prednisolone 0-12 interleukin 18 Homo sapiens 21-35 12365719-4 2002 METHODS: IL-18 transcript and protein levels in PBMC from untreated and prednisolone treated RA patients, and from healthy donors were assessed by semiquantitative reverse transcriptase polymerase chain reaction (RT-PCR) and immunoblotting. Prednisolone 72-84 interleukin 18 Homo sapiens 9-14 12365719-5 2002 IL-18 regulation was determined in PBMC and U937 cells upon exposure to prednisolone in vitro by RT-PCR and Northern Blot analysis, by ELISA in cell culture supernatants, and in transiently transfected THP-1 cells by IL-18 promoter activity luciferase assays. Prednisolone 72-84 interleukin 18 Homo sapiens 0-5 12365719-6 2002 RESULTS: In RA PBMC, IL-18 transcript levels were dose dependently restored, in parallel with administered prednisolone treatment, to subnormal levels. Prednisolone 107-119 interleukin 18 Homo sapiens 21-26 12365719-8 2002 In cultured PBMC and promonocytic cell lines, prednisolone up-regulated IL-18 transcription in parallel with increasing the IL- 18 protein release into cell culture supernatants. Prednisolone 46-58 interleukin 18 Homo sapiens 72-77 12365719-8 2002 In cultured PBMC and promonocytic cell lines, prednisolone up-regulated IL-18 transcription in parallel with increasing the IL- 18 protein release into cell culture supernatants. Prednisolone 46-58 interleukin 18 Homo sapiens 124-130 12365719-9 2002 CONCLUSION: Prednisolone increases IL-18 expression and release in PBMC and monocytic cell lines. Prednisolone 12-24 interleukin 18 Homo sapiens 35-40 12117681-6 2002 After six months" treatment with methotrexate, IL18 levels were reduced, but the differences were not significant (p=0.052). Methotrexate 33-45 interleukin 18 Homo sapiens 47-51 12076961-2 2002 Nitric oxide inhibits apoptosis and inflammation by S-nitrosylation of the active site cysteine of caspases, the central effector molecules of cell death as well as maturation of IL-1beta and IL-18. Nitric Oxide 0-12 interleukin 18 Homo sapiens 192-197 12149432-8 2002 IL-18 activation of PMNs was blocked by inhibition of p38 MAP kinase activity (SB203580) or by inhibition of p38 MAP kinase activation by chelation of cytosolic Ca2+. SB 203580 79-87 interleukin 18 Homo sapiens 0-5 12136075-1 2002 In this study, the authors show that MG as an autoantibody-mediated disorder of neuromuscular transmission is associated with elevated serum levels of the interferon-gamma-inducing cytokine interleukin (IL)-18. Magnesium 37-39 interleukin 18 Homo sapiens 190-209 12101280-3 2002 IL-12 and IL-18 induced T cell adhesion to fibronectin (FN) and hyaluronic acid at low (pM) concentrations that were mediated by specific adhesion molecules expressed on the T cell surface, namely, beta(1) integrins and CD44, respectively. Hyaluronic Acid 64-79 interleukin 18 Homo sapiens 10-15 12101280-4 2002 The induction of adhesion by IL-12 and IL-18 was inhibited by extracellular signal-regulated kinase and p38 mitogen-activated protein kinase inhibitors (PD098059 and SB203580, respectively). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 153-161 interleukin 18 Homo sapiens 39-44 12101280-4 2002 The induction of adhesion by IL-12 and IL-18 was inhibited by extracellular signal-regulated kinase and p38 mitogen-activated protein kinase inhibitors (PD098059 and SB203580, respectively). SB 203580 166-174 interleukin 18 Homo sapiens 39-44 12101280-5 2002 In contrast, IL-12- and IL-18-induced interferon-gamma (INF-gamma) secretion from T cells was inhibited by SB203580, but not by PD098059. SB 203580 107-115 interleukin 18 Homo sapiens 24-29 12067307-9 2002 Our findings suggest that patients with MDRTB have dysregulated IL-12, IL-18 and IL-10 production during Mycobacterium tuberculosis infection, and the cytokine profiles are similar to those in patients with drug-sensitive advanced TB previously reported in the literature. Terbium 43-45 interleukin 18 Homo sapiens 71-76 12010883-6 2002 METHODS: Mice with dextran sulphate sodium (DSS) induced colitis were treated with recombinant IL-18 binding protein (IL-18bp.Fc), a soluble protein that blocks IL-18 bioactivity. dextran sulphate sodium 19-42 interleukin 18 Homo sapiens 95-100 12010883-6 2002 METHODS: Mice with dextran sulphate sodium (DSS) induced colitis were treated with recombinant IL-18 binding protein (IL-18bp.Fc), a soluble protein that blocks IL-18 bioactivity. dss 44-47 interleukin 18 Homo sapiens 95-100 11944905-2 2002 Here we showed that HDAC inhibitors sodium butyrate, TSA, and valproate regulated the expression of Interleukin-18 (IL-18), a cytokine with antitumor and proinflammatory properties, in human acute myeloid leukemia cell lines U937 and HEL. hdac 20-24 interleukin 18 Homo sapiens 100-114 11944905-2 2002 Here we showed that HDAC inhibitors sodium butyrate, TSA, and valproate regulated the expression of Interleukin-18 (IL-18), a cytokine with antitumor and proinflammatory properties, in human acute myeloid leukemia cell lines U937 and HEL. Butyric Acid 36-51 interleukin 18 Homo sapiens 116-121 12027422-4 2002 Investigation of IFNgamma-stimulatory cytokine involvement indicated that lavage cell IL-18 was significantly increased (fourfold) by BE and reduced (64%) by DETA NONOate but IL-12 was undetectable. Beryllium 134-136 interleukin 18 Homo sapiens 86-91 12027422-4 2002 Investigation of IFNgamma-stimulatory cytokine involvement indicated that lavage cell IL-18 was significantly increased (fourfold) by BE and reduced (64%) by DETA NONOate but IL-12 was undetectable. 2,2'-(hydroxynitrosohydrazono)bis-ethanamine 158-170 interleukin 18 Homo sapiens 86-91 11970988-0 2002 Prostaglandin E(2) inhibits IL-18-induced ICAM-1 and B7.2 expression through EP2/EP4 receptors in human peripheral blood mononuclear cells. Dinoprostone 0-18 interleukin 18 Homo sapiens 28-33 11970988-2 2002 In the present study we investigated the effects of PGE(2) on the expression of ICAM-1, B7.1, and B7.2 on monocytes in IL-18-stimulated PBMC using FACS analysis. Prostaglandins E 52-55 interleukin 18 Homo sapiens 119-124 11970988-3 2002 Addition of PGE(2) to PBMC inhibited ICAM-1 and B7.2 expression elicited by IL-18 in a concentration-dependent manner. Dinoprostone 12-18 interleukin 18 Homo sapiens 76-81 11970988-5 2002 ONO-AE1-259-01 (EP2R agonist) inhibited IL-18-elicited ICAM-1 and B7.2 expression in a concentration-dependent manner with a potency slightly less than that of PGE(2), while ONO-AE1-329 (EP4R agonist) was much less potent than PGE(2). Prostaglandins E 227-230 interleukin 18 Homo sapiens 40-45 11970988-9 2002 Dibutyryl cAMP and forskolin down-regulated ICAM-1 and B7.2 expression in IL-18-stimulated monocytes. dibutyryl 0-9 interleukin 18 Homo sapiens 74-79 11970988-9 2002 Dibutyryl cAMP and forskolin down-regulated ICAM-1 and B7.2 expression in IL-18-stimulated monocytes. Cyclic AMP 10-14 interleukin 18 Homo sapiens 74-79 11970988-9 2002 Dibutyryl cAMP and forskolin down-regulated ICAM-1 and B7.2 expression in IL-18-stimulated monocytes. Colforsin 19-28 interleukin 18 Homo sapiens 74-79 11970988-10 2002 As EP2 and EP4Rs are coupled to adenylate cyclase, we suggest that PGE(2) down-regulates IL-18-induced ICAM-1 and B7.2 expression in monocytes via EP2 and EP4Rs by cAMP-dependent signaling pathways. Dinoprostone 67-73 interleukin 18 Homo sapiens 89-94 11970988-10 2002 As EP2 and EP4Rs are coupled to adenylate cyclase, we suggest that PGE(2) down-regulates IL-18-induced ICAM-1 and B7.2 expression in monocytes via EP2 and EP4Rs by cAMP-dependent signaling pathways. Cyclic AMP 164-168 interleukin 18 Homo sapiens 89-94 11970988-11 2002 The fact that anti-B7.2 as well as anti-ICAM-1 Ab inhibited IL-18-induced cytokine production implies that PGE(2) may modulate the immune response through regulation of the expression of particular adhesion molecules on monocytes via EP2 and EP4Rs. Prostaglandins E 107-110 interleukin 18 Homo sapiens 60-65 11944905-2 2002 Here we showed that HDAC inhibitors sodium butyrate, TSA, and valproate regulated the expression of Interleukin-18 (IL-18), a cytokine with antitumor and proinflammatory properties, in human acute myeloid leukemia cell lines U937 and HEL. trichostatin A 53-56 interleukin 18 Homo sapiens 100-114 11944905-2 2002 Here we showed that HDAC inhibitors sodium butyrate, TSA, and valproate regulated the expression of Interleukin-18 (IL-18), a cytokine with antitumor and proinflammatory properties, in human acute myeloid leukemia cell lines U937 and HEL. trichostatin A 53-56 interleukin 18 Homo sapiens 116-121 11944905-2 2002 Here we showed that HDAC inhibitors sodium butyrate, TSA, and valproate regulated the expression of Interleukin-18 (IL-18), a cytokine with antitumor and proinflammatory properties, in human acute myeloid leukemia cell lines U937 and HEL. Valproic Acid 62-71 interleukin 18 Homo sapiens 100-114 11944905-2 2002 Here we showed that HDAC inhibitors sodium butyrate, TSA, and valproate regulated the expression of Interleukin-18 (IL-18), a cytokine with antitumor and proinflammatory properties, in human acute myeloid leukemia cell lines U937 and HEL. Valproic Acid 62-71 interleukin 18 Homo sapiens 116-121 11944905-3 2002 Sodium butyrate increased expression of IL-18 protein and mRNA and activated 1357bp IL-18 gene promoter construct. Butyric Acid 0-15 interleukin 18 Homo sapiens 40-45 11944905-3 2002 Sodium butyrate increased expression of IL-18 protein and mRNA and activated 1357bp IL-18 gene promoter construct. Butyric Acid 0-15 interleukin 18 Homo sapiens 84-89 11944905-4 2002 IL-18 mRNA level was up-regulated by TSA or valproate, which also activated IL-18 full-length promoter. trichostatin A 37-40 interleukin 18 Homo sapiens 0-5 11944905-2 2002 Here we showed that HDAC inhibitors sodium butyrate, TSA, and valproate regulated the expression of Interleukin-18 (IL-18), a cytokine with antitumor and proinflammatory properties, in human acute myeloid leukemia cell lines U937 and HEL. hdac 20-24 interleukin 18 Homo sapiens 116-121 11944905-4 2002 IL-18 mRNA level was up-regulated by TSA or valproate, which also activated IL-18 full-length promoter. trichostatin A 37-40 interleukin 18 Homo sapiens 76-81 11944905-4 2002 IL-18 mRNA level was up-regulated by TSA or valproate, which also activated IL-18 full-length promoter. Valproic Acid 44-53 interleukin 18 Homo sapiens 0-5 11944905-2 2002 Here we showed that HDAC inhibitors sodium butyrate, TSA, and valproate regulated the expression of Interleukin-18 (IL-18), a cytokine with antitumor and proinflammatory properties, in human acute myeloid leukemia cell lines U937 and HEL. Butyric Acid 36-51 interleukin 18 Homo sapiens 100-114 11944905-4 2002 IL-18 mRNA level was up-regulated by TSA or valproate, which also activated IL-18 full-length promoter. Valproic Acid 44-53 interleukin 18 Homo sapiens 76-81 11790772-2 2002 Computer modeling of human IL-18 identified two charged residues, Glu-42 and Lys-89, which interact with oppositely charged amino acid residues buried in a large hydrophobic pocket of IL-18BP. Lysine 77-80 interleukin 18 Homo sapiens 27-32 11944905-5 2002 While sodium butyrate or TSA stimulated the 108-bp IL-18 minimal promoter, valproate failed to activate it, indicating that valproate may use a distinct mechanism from sodium butyrate and TSA to activate IL-18 gene expression. Butyric Acid 6-21 interleukin 18 Homo sapiens 51-56 11944905-5 2002 While sodium butyrate or TSA stimulated the 108-bp IL-18 minimal promoter, valproate failed to activate it, indicating that valproate may use a distinct mechanism from sodium butyrate and TSA to activate IL-18 gene expression. trichostatin A 25-28 interleukin 18 Homo sapiens 51-56 11944905-5 2002 While sodium butyrate or TSA stimulated the 108-bp IL-18 minimal promoter, valproate failed to activate it, indicating that valproate may use a distinct mechanism from sodium butyrate and TSA to activate IL-18 gene expression. Valproic Acid 124-133 interleukin 18 Homo sapiens 204-209 12019734-5 2002 This study demonstrates for the first time that "in vitro" pretreatment with gentamicin-killed H. pylori of PBMC, followed by infection with live bacteria, downregulates the production of inflammatory cytokines such as IL-18 and IFNgamma Our results provide a possible strategy to restore the immunological disorders determined by H. pylori infection. Gentamicins 77-87 interleukin 18 Homo sapiens 219-224 11790772-2 2002 Computer modeling of human IL-18 identified two charged residues, Glu-42 and Lys-89, which interact with oppositely charged amino acid residues buried in a large hydrophobic pocket of IL-18BP. Glutamic Acid 66-69 interleukin 18 Homo sapiens 27-32 11790772-10 2002 The present study reveals that Glu-42 and Lys-89 are critical amino acid residues for the integrity of IL-18 structure and are important for binding to cell surface receptors, for signal transduction, and for neutralization by IL-18BP. Glutamic Acid 31-34 interleukin 18 Homo sapiens 103-108 11790772-10 2002 The present study reveals that Glu-42 and Lys-89 are critical amino acid residues for the integrity of IL-18 structure and are important for binding to cell surface receptors, for signal transduction, and for neutralization by IL-18BP. Lysine 42-45 interleukin 18 Homo sapiens 103-108 12048352-0 2002 Relation between interleukin-18 and PGE2 in synovial fluid of osteoarthritis: a potential therapeutic target of cartilage degradation. Dinoprostone 36-40 interleukin 18 Homo sapiens 17-31 11886764-8 2002 There was an inverse relationship between serum DHEA and DHEA-S levels and both IL-6 (r= -0.46, P<0.02) or IL-18 (r= -0.38, P<0.05) serum concentrations. Dehydroepiandrosterone 48-52 interleukin 18 Homo sapiens 110-115 11886764-8 2002 There was an inverse relationship between serum DHEA and DHEA-S levels and both IL-6 (r= -0.46, P<0.02) or IL-18 (r= -0.38, P<0.05) serum concentrations. Dehydroepiandrosterone 57-63 interleukin 18 Homo sapiens 110-115 12025522-6 2002 Steroids suppressed the production of IL-18 and other secondary cytokines in LPS/IL-2-stimulated PBMCs, in a concentration- and time-dependent manner, although inhibition was incomplete even at high concentrations. Steroids 0-8 interleukin 18 Homo sapiens 38-43 12048352-2 2002 Interleukin (IL)-18 is a potent inducer of prostaglandin (PG) E2 in vitro. Dinoprostone 43-64 interleukin 18 Homo sapiens 0-19 12025532-6 2002 The results suggest that gabexate mesilate-induced inhibition of tumour necrosis factor-alpha (TNF-alpha) and interleukin-18 (IL-18) production in LPS-stimulated PBMCs is due to the inhibition of the nuclear factor-kappa B activation pathway and/or inhibition of the processing pathway of pro-TNF-alpha and pro-IL-18, not to down-regulation of TLR-2 or TLR-4. Gabexate 25-42 interleukin 18 Homo sapiens 110-124 12025522-0 2002 Effect of steroids on lipopolysaccharide/interleukin 2-induced interleukin 18 production in peripheral blood mononuclear cells. Steroids 10-18 interleukin 18 Homo sapiens 63-77 12025532-6 2002 The results suggest that gabexate mesilate-induced inhibition of tumour necrosis factor-alpha (TNF-alpha) and interleukin-18 (IL-18) production in LPS-stimulated PBMCs is due to the inhibition of the nuclear factor-kappa B activation pathway and/or inhibition of the processing pathway of pro-TNF-alpha and pro-IL-18, not to down-regulation of TLR-2 or TLR-4. Gabexate 25-42 interleukin 18 Homo sapiens 126-131 12025532-6 2002 The results suggest that gabexate mesilate-induced inhibition of tumour necrosis factor-alpha (TNF-alpha) and interleukin-18 (IL-18) production in LPS-stimulated PBMCs is due to the inhibition of the nuclear factor-kappa B activation pathway and/or inhibition of the processing pathway of pro-TNF-alpha and pro-IL-18, not to down-regulation of TLR-2 or TLR-4. Gabexate 25-42 interleukin 18 Homo sapiens 311-316 12048352-9 2002 There was a relatively strong correlation between IL-18 and PGE2 (r = 0.78, p = 0.0001). Dinoprostone 60-64 interleukin 18 Homo sapiens 50-55 12048352-14 2002 Our results suggest that IL-18 could play a major role in vivo in inducing the production of PGE2, which in turn can cause cartilage degradation in OA pathogenesis. Dinoprostone 93-97 interleukin 18 Homo sapiens 25-30 12048356-3 2002 Interestingly, the increase in the plasma IL-18 concentration was correlated with that in serum bilirubin levels in hepatectomized patients. Bilirubin 96-105 interleukin 18 Homo sapiens 42-47 11801649-5 2002 An increase in c-Jun, a component of AP-1, in the nuclear compartment was elicited by stimulation with either IL-12 or IL-18, but accumulation of serine-phosphorylated c-Jun was induced only by IL-18 capable of activating c-Jun N-terminal kinase. Serine 146-152 interleukin 18 Homo sapiens 194-199 11862579-3 2002 Interleukin (IL)-18, a newly discovered cytokine with pleiotropic activities, is known to induce proinflammatory cytokines, chemokines, nitric oxide, and prostaglandins. Nitric Oxide 136-148 interleukin 18 Homo sapiens 0-19 11862579-3 2002 Interleukin (IL)-18, a newly discovered cytokine with pleiotropic activities, is known to induce proinflammatory cytokines, chemokines, nitric oxide, and prostaglandins. Prostaglandins 154-168 interleukin 18 Homo sapiens 0-19 12325458-1 2002 Deep sea water intake improves skin symptoms and mineral imbalance and decreases serum IgE levels mad IgE-inducing cytokines, IL-4, IL-13 and IL-18 in patients with atopic eczema/dermatitis syndrome (AEDS), while distilled water intake fails to do so. Water 9-14 interleukin 18 Homo sapiens 142-147 14660053-4 2002 NK-cell activation in response to IL-12 and IL-18 was investigated by selective flow cytometry using propidium iodide. Propidium 101-117 interleukin 18 Homo sapiens 44-49 11936589-0 2002 Influence of 5-fluorouracil and folinic acid on interleukin-18 production in colorectal cancer patients. Fluorouracil 13-27 interleukin 18 Homo sapiens 48-62 12572773-4 2002 In our previous study we found the significant down-regulation of interleukin 18 (IL-18), a proinflammatory cytokine inducing the production of interferon gamma during therapy with GA in MS patients. Glatiramer Acetate 181-183 interleukin 18 Homo sapiens 66-80 12572773-4 2002 In our previous study we found the significant down-regulation of interleukin 18 (IL-18), a proinflammatory cytokine inducing the production of interferon gamma during therapy with GA in MS patients. Glatiramer Acetate 181-183 interleukin 18 Homo sapiens 82-87 11936589-0 2002 Influence of 5-fluorouracil and folinic acid on interleukin-18 production in colorectal cancer patients. Leucovorin 32-44 interleukin 18 Homo sapiens 48-62 11936589-1 2002 AIMS AND BACKGROUND: This study was carried out to evaluate the IL-18 blood concentrations of operated colorectal cancer patients and their possible variation in response to combination chemotherapy with 5-fluorouracil (5-FU) and folinic acid. Fluorouracil 204-218 interleukin 18 Homo sapiens 64-69 11936589-1 2002 AIMS AND BACKGROUND: This study was carried out to evaluate the IL-18 blood concentrations of operated colorectal cancer patients and their possible variation in response to combination chemotherapy with 5-fluorouracil (5-FU) and folinic acid. Fluorouracil 220-224 interleukin 18 Homo sapiens 64-69 11936589-1 2002 AIMS AND BACKGROUND: This study was carried out to evaluate the IL-18 blood concentrations of operated colorectal cancer patients and their possible variation in response to combination chemotherapy with 5-fluorouracil (5-FU) and folinic acid. Leucovorin 230-242 interleukin 18 Homo sapiens 64-69 11936589-2 2002 METHODS: IL-18 levels were assayed in sera of 18 healthy donors and 18 surgical colorectal cancer patients before and after adjuvant chemotherapy with 5-fluorouracil and folinic acid. Fluorouracil 151-165 interleukin 18 Homo sapiens 9-14 11936589-2 2002 METHODS: IL-18 levels were assayed in sera of 18 healthy donors and 18 surgical colorectal cancer patients before and after adjuvant chemotherapy with 5-fluorouracil and folinic acid. Leucovorin 170-182 interleukin 18 Homo sapiens 9-14 11936589-6 2002 CONCLUSIONS: This study suggests that treatment with 5-fluorouracil and folinic acid may provoke an increase in IL-18 serum levels in colorectal cancer patients. Fluorouracil 53-67 interleukin 18 Homo sapiens 112-117 11936589-6 2002 CONCLUSIONS: This study suggests that treatment with 5-fluorouracil and folinic acid may provoke an increase in IL-18 serum levels in colorectal cancer patients. Leucovorin 72-84 interleukin 18 Homo sapiens 112-117 11752121-4 2002 The inhibition of IL-18-induced IFN-gamma by histamine was ascribed to the strong inhibition of IL-12 production by histamine. Histamine 45-54 interleukin 18 Homo sapiens 18-23 11751987-3 2002 To specifically down-regulate IL-18 expression in this model, we constructed an E1/E3-deleted adenovirus expressing IL-18 antisense mRNA, denoted Ad-asIL-18, and demonstrated the capacity of such a vector to down-regulate IL-18 expression in colon-derived DLD-1 cells and RAW264.7 macrophages. asil 149-153 interleukin 18 Homo sapiens 116-121 11751987-3 2002 To specifically down-regulate IL-18 expression in this model, we constructed an E1/E3-deleted adenovirus expressing IL-18 antisense mRNA, denoted Ad-asIL-18, and demonstrated the capacity of such a vector to down-regulate IL-18 expression in colon-derived DLD-1 cells and RAW264.7 macrophages. asil 149-153 interleukin 18 Homo sapiens 116-121 11752121-2 2002 In the present study, we demonstrate that histamine inhibited the ICAM-1 expression in monocytes induced by IL-18 using flow cytometry and that the responses of IL-12, IFN-gamma, and TNF-alpha induced by IL-18 were concentration dependently inhibited by coexisting histamine, whereas IL-18-inhibited IL-10 production was reversed by the same concentrations of histamine. Histamine 42-51 interleukin 18 Homo sapiens 108-113 11752121-4 2002 The inhibition of IL-18-induced IFN-gamma by histamine was ascribed to the strong inhibition of IL-12 production by histamine. Histamine 116-125 interleukin 18 Homo sapiens 18-23 11752121-2 2002 In the present study, we demonstrate that histamine inhibited the ICAM-1 expression in monocytes induced by IL-18 using flow cytometry and that the responses of IL-12, IFN-gamma, and TNF-alpha induced by IL-18 were concentration dependently inhibited by coexisting histamine, whereas IL-18-inhibited IL-10 production was reversed by the same concentrations of histamine. Histamine 42-51 interleukin 18 Homo sapiens 204-209 11958135-0 2002 [Site-directed mutagenesis of the cysteines of human IL-18 and its effect on IL-18 activity]. Cysteine 34-43 interleukin 18 Homo sapiens 53-58 11752121-2 2002 In the present study, we demonstrate that histamine inhibited the ICAM-1 expression in monocytes induced by IL-18 using flow cytometry and that the responses of IL-12, IFN-gamma, and TNF-alpha induced by IL-18 were concentration dependently inhibited by coexisting histamine, whereas IL-18-inhibited IL-10 production was reversed by the same concentrations of histamine. Histamine 42-51 interleukin 18 Homo sapiens 204-209 11752121-2 2002 In the present study, we demonstrate that histamine inhibited the ICAM-1 expression in monocytes induced by IL-18 using flow cytometry and that the responses of IL-12, IFN-gamma, and TNF-alpha induced by IL-18 were concentration dependently inhibited by coexisting histamine, whereas IL-18-inhibited IL-10 production was reversed by the same concentrations of histamine. Histamine 265-274 interleukin 18 Homo sapiens 204-209 11752121-2 2002 In the present study, we demonstrate that histamine inhibited the ICAM-1 expression in monocytes induced by IL-18 using flow cytometry and that the responses of IL-12, IFN-gamma, and TNF-alpha induced by IL-18 were concentration dependently inhibited by coexisting histamine, whereas IL-18-inhibited IL-10 production was reversed by the same concentrations of histamine. Histamine 265-274 interleukin 18 Homo sapiens 204-209 11752121-2 2002 In the present study, we demonstrate that histamine inhibited the ICAM-1 expression in monocytes induced by IL-18 using flow cytometry and that the responses of IL-12, IFN-gamma, and TNF-alpha induced by IL-18 were concentration dependently inhibited by coexisting histamine, whereas IL-18-inhibited IL-10 production was reversed by the same concentrations of histamine. Histamine 265-274 interleukin 18 Homo sapiens 204-209 11752121-2 2002 In the present study, we demonstrate that histamine inhibited the ICAM-1 expression in monocytes induced by IL-18 using flow cytometry and that the responses of IL-12, IFN-gamma, and TNF-alpha induced by IL-18 were concentration dependently inhibited by coexisting histamine, whereas IL-18-inhibited IL-10 production was reversed by the same concentrations of histamine. Histamine 265-274 interleukin 18 Homo sapiens 204-209 11958135-0 2002 [Site-directed mutagenesis of the cysteines of human IL-18 and its effect on IL-18 activity]. Cysteine 34-43 interleukin 18 Homo sapiens 77-82 11958135-1 2002 To study the structure-function relationships of human IL-18(hIL-18), site-directed mutagenesis was used to generate four hIL-18 cysteine mutants, C74S, C104S, C112S and C163S. Cysteine 129-137 interleukin 18 Homo sapiens 122-128 11739524-11 2001 Down-regulation of IL-18BPa by sodium butyrate suggests that reinforcement of local IL-18 activity may contribute to actions of this short-chain fatty acid in the colonic microenvironment. Butyric Acid 31-46 interleukin 18 Homo sapiens 19-24 11739524-11 2001 Down-regulation of IL-18BPa by sodium butyrate suggests that reinforcement of local IL-18 activity may contribute to actions of this short-chain fatty acid in the colonic microenvironment. Fatty Acids, Volatile 133-155 interleukin 18 Homo sapiens 19-24 11600201-5 2001 ELISA tests showed that IL-18 was highly expressed in malignant skin tumors such as SK-MES-1, SK-MEL-2, G-361, DM-4, and DX-3 cell lines, thus suggesting that IL-18 production may be associated with the malignancy of skin tumors. sk-mes 84-90 interleukin 18 Homo sapiens 24-29 11729116-5 2001 METHODS: Activity of IL-18 was neutralized using recombinant human IL-18 binding protein isoform a (rhIL-18BPa) in trinitrobenzene sulfonic acid (TNBS)-induced colitis. Trinitrobenzenesulfonic Acid 115-144 interleukin 18 Homo sapiens 21-26 11729116-5 2001 METHODS: Activity of IL-18 was neutralized using recombinant human IL-18 binding protein isoform a (rhIL-18BPa) in trinitrobenzene sulfonic acid (TNBS)-induced colitis. Trinitrobenzenesulfonic Acid 115-144 interleukin 18 Homo sapiens 67-72 11729116-5 2001 METHODS: Activity of IL-18 was neutralized using recombinant human IL-18 binding protein isoform a (rhIL-18BPa) in trinitrobenzene sulfonic acid (TNBS)-induced colitis. Trinitrobenzenesulfonic Acid 146-150 interleukin 18 Homo sapiens 21-26 11729116-5 2001 METHODS: Activity of IL-18 was neutralized using recombinant human IL-18 binding protein isoform a (rhIL-18BPa) in trinitrobenzene sulfonic acid (TNBS)-induced colitis. Trinitrobenzenesulfonic Acid 146-150 interleukin 18 Homo sapiens 67-72 11590389-9 2001 The anti-PGE(2) antibody reversed the suppressive effect of PGE(2) on IL-18 secretion in unstimulated PBMCs from patients with AD. Prostaglandins E 9-12 interleukin 18 Homo sapiens 70-75 11714826-5 2001 An active 18-kDa form of IL-18 was detected in lysate and supernatant of the cells only after the above treatment and the induction was inhibited by cycloheximide and by serine proteinase inhibitors. Cycloheximide 149-162 interleukin 18 Homo sapiens 25-30 11477102-0 2001 A novel role for interleukin-18 in adhesion molecule induction through NF kappa B and phosphatidylinositol (PI) 3-kinase-dependent signal transduction pathways. Phosphatidylinositols 86-106 interleukin 18 Homo sapiens 17-31 11477102-8 2001 IL-18-induced adhesion molecule expression appears to be mediated through nuclear factor kappa B (NF kappa B) and phosphatidyl-inositol 3 kinase (PI 3-kinase) since addition of inhibitors to either NF kappa B (pyrrolidine dithiocarbamate and N-acetyl-l-cysteine) or PI 3-kinase (LY294002) inhibited RA synovial fibroblast VCAM-1 expression by 50 to 60%. Dithiocarbamate 222-237 interleukin 18 Homo sapiens 0-5 11477102-8 2001 IL-18-induced adhesion molecule expression appears to be mediated through nuclear factor kappa B (NF kappa B) and phosphatidyl-inositol 3 kinase (PI 3-kinase) since addition of inhibitors to either NF kappa B (pyrrolidine dithiocarbamate and N-acetyl-l-cysteine) or PI 3-kinase (LY294002) inhibited RA synovial fibroblast VCAM-1 expression by 50 to 60%. Nitrogen 98-99 interleukin 18 Homo sapiens 0-5 11477102-8 2001 IL-18-induced adhesion molecule expression appears to be mediated through nuclear factor kappa B (NF kappa B) and phosphatidyl-inositol 3 kinase (PI 3-kinase) since addition of inhibitors to either NF kappa B (pyrrolidine dithiocarbamate and N-acetyl-l-cysteine) or PI 3-kinase (LY294002) inhibited RA synovial fibroblast VCAM-1 expression by 50 to 60%. N-Acetyl-L-cysteine 244-261 interleukin 18 Homo sapiens 0-5 11477102-8 2001 IL-18-induced adhesion molecule expression appears to be mediated through nuclear factor kappa B (NF kappa B) and phosphatidyl-inositol 3 kinase (PI 3-kinase) since addition of inhibitors to either NF kappa B (pyrrolidine dithiocarbamate and N-acetyl-l-cysteine) or PI 3-kinase (LY294002) inhibited RA synovial fibroblast VCAM-1 expression by 50 to 60%. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 279-287 interleukin 18 Homo sapiens 0-5 11590389-9 2001 The anti-PGE(2) antibody reversed the suppressive effect of PGE(2) on IL-18 secretion in unstimulated PBMCs from patients with AD. Prostaglandins E 60-63 interleukin 18 Homo sapiens 70-75 11559827-4 2001 Model building indicated that MC54L, which has been shown to bind hIL-18, contains five of the seven amino acids at corresponding positions in its immunoglobulin-like domain, the exceptions being the conservative substitution of isoleucine for a leucine and the nonconservative substitution of valine for a phenylalanine. Isoleucine 229-239 interleukin 18 Homo sapiens 66-72 11559827-4 2001 Model building indicated that MC54L, which has been shown to bind hIL-18, contains five of the seven amino acids at corresponding positions in its immunoglobulin-like domain, the exceptions being the conservative substitution of isoleucine for a leucine and the nonconservative substitution of valine for a phenylalanine. Leucine 232-239 interleukin 18 Homo sapiens 66-72 11559827-5 2001 We found that individual alanine substitutions for these six identical or highly conserved amino acids of MC54L caused changes in affinity and binding free energy for hIL-18 that were quantitatively similar to those produced by mutagenesis of hIL-18BP. Alanine 25-32 interleukin 18 Homo sapiens 167-173 11559827-6 2001 Furthermore, when the nonconserved valine of MC54L was mutated to phenylalanine, making it more like hIL-18BP, its affinity for hIL-18 increased more than 10-fold. Valine 35-41 interleukin 18 Homo sapiens 101-107 11559827-6 2001 Furthermore, when the nonconserved valine of MC54L was mutated to phenylalanine, making it more like hIL-18BP, its affinity for hIL-18 increased more than 10-fold. Phenylalanine 66-79 interleukin 18 Homo sapiens 101-107 11598150-7 2001 IL-18 induces IL-8 secretion through NFkappaB because RA synovial fibroblasts pretreated with antisense to NFkappaB p65 oligonucleotide produce a mean of 44% less IL-8 compared with cells pretreated with the control sense oligonucleotide. Oligonucleotides 120-135 interleukin 18 Homo sapiens 0-5 11598150-7 2001 IL-18 induces IL-8 secretion through NFkappaB because RA synovial fibroblasts pretreated with antisense to NFkappaB p65 oligonucleotide produce a mean of 44% less IL-8 compared with cells pretreated with the control sense oligonucleotide. Oligonucleotides 222-237 interleukin 18 Homo sapiens 0-5 11551238-2 2001 The purpose of the study was to measure IL-18 levels in serum and CSF of 21 patients with the relapsing-remitting form of MS, 9 with active gadolinium enhancing lesions in MRI and 12 without enhancing lesions, and to compare results with control group consisting of 11 patients with diagnosis of neurasthenia and tension headache. Gadolinium 140-150 interleukin 18 Homo sapiens 40-45 11509635-6 2001 Finally, IL-18 administration promoted neutrophil accumulation in vivo, whereas IL-18 neutralization suppressed the severity of footpad inflammation following carrageenan injection. Carrageenan 159-170 interleukin 18 Homo sapiens 80-85 11496824-7 2001 All effects of histamine were abolished by the presence of anti-IL-18 antibody or IL-1b-converting enzyme/caspase-1 inhibitor, indicating that histamine action is dependent on mature IL-18 secretion and that IL-18 production was present most upstream of the cytokine cascade triggered by histamine. Histamine 15-24 interleukin 18 Homo sapiens 64-69 11496824-7 2001 All effects of histamine were abolished by the presence of anti-IL-18 antibody or IL-1b-converting enzyme/caspase-1 inhibitor, indicating that histamine action is dependent on mature IL-18 secretion and that IL-18 production was present most upstream of the cytokine cascade triggered by histamine. Histamine 15-24 interleukin 18 Homo sapiens 183-188 11496824-4 2001 Using human PBMC culture, it was demonstrated that histamine was a potent inducer of IL-18, IFN-gamma in human PBMC. Histamine 51-60 interleukin 18 Homo sapiens 85-90 11496824-7 2001 All effects of histamine were abolished by the presence of anti-IL-18 antibody or IL-1b-converting enzyme/caspase-1 inhibitor, indicating that histamine action is dependent on mature IL-18 secretion and that IL-18 production was present most upstream of the cytokine cascade triggered by histamine. Histamine 15-24 interleukin 18 Homo sapiens 183-188 11496824-7 2001 All effects of histamine were abolished by the presence of anti-IL-18 antibody or IL-1b-converting enzyme/caspase-1 inhibitor, indicating that histamine action is dependent on mature IL-18 secretion and that IL-18 production was present most upstream of the cytokine cascade triggered by histamine. Histamine 143-152 interleukin 18 Homo sapiens 64-69 11496824-7 2001 All effects of histamine were abolished by the presence of anti-IL-18 antibody or IL-1b-converting enzyme/caspase-1 inhibitor, indicating that histamine action is dependent on mature IL-18 secretion and that IL-18 production was present most upstream of the cytokine cascade triggered by histamine. Histamine 143-152 interleukin 18 Homo sapiens 183-188 11496824-7 2001 All effects of histamine were abolished by the presence of anti-IL-18 antibody or IL-1b-converting enzyme/caspase-1 inhibitor, indicating that histamine action is dependent on mature IL-18 secretion and that IL-18 production was present most upstream of the cytokine cascade triggered by histamine. Histamine 143-152 interleukin 18 Homo sapiens 183-188 11496824-7 2001 All effects of histamine were abolished by the presence of anti-IL-18 antibody or IL-1b-converting enzyme/caspase-1 inhibitor, indicating that histamine action is dependent on mature IL-18 secretion and that IL-18 production was present most upstream of the cytokine cascade triggered by histamine. Histamine 143-152 interleukin 18 Homo sapiens 64-69 11496824-7 2001 All effects of histamine were abolished by the presence of anti-IL-18 antibody or IL-1b-converting enzyme/caspase-1 inhibitor, indicating that histamine action is dependent on mature IL-18 secretion and that IL-18 production was present most upstream of the cytokine cascade triggered by histamine. Histamine 143-152 interleukin 18 Homo sapiens 183-188 11496824-7 2001 All effects of histamine were abolished by the presence of anti-IL-18 antibody or IL-1b-converting enzyme/caspase-1 inhibitor, indicating that histamine action is dependent on mature IL-18 secretion and that IL-18 production was present most upstream of the cytokine cascade triggered by histamine. Histamine 143-152 interleukin 18 Homo sapiens 183-188 11278524-4 2001 The mutated IL-18BPs were secreted from mammalian cells, captured by metal affinity chromatography, biotinylated in situ, eluted, and immobilized on streptavidin-coated chips. Metals 69-74 interleukin 18 Homo sapiens 12-17 11359822-8 2001 Hence, human IgM carries functionally inactive IL-18 forming a disulfide-bridged complex, and this IL-18 moiety is from 10- to 100-fold higher than the conventional type 1 IL-18 in blood circulation in approximately 30% normal subjects. Disulfides 63-72 interleukin 18 Homo sapiens 99-104 11798931-4 2001 Employing the antisense technique, we ionvestigated the effects of IL-18 antisense oligodeoxynucleiotide (ASODN) on the proliferation of J6-1 cells. asodn 106-111 interleukin 18 Homo sapiens 67-72 11278524-3 2001 We genetically modified the C terminus of hIL-18BP by appending a 15-amino acid biotinylation recognition site and a six-histidine tag and then performed site-directed mutagenesis to determine the functional epitopes that mediate efficient binding to IL-18. Histidine 121-130 interleukin 18 Homo sapiens 43-48 11298325-4 2001 Flow cytometry and RT-PCR analyses revealed that the treatment of YY-1 cells with n-butyric acid promoted cell maturation and caused an enhancement of IL-18 receptor alpha chain expression. Fatty Acids 82-96 interleukin 18 Homo sapiens 151-156 11464579-9 2001 ELISA was also used to measure the release of soluble Fas from IL-18-stimulated amniochorion in culture media. ammonium ferrous sulfate 54-57 interleukin 18 Homo sapiens 63-68 11464579-13 2001 Soluble Fas release from amniochorion was increased after IL-18 stimulation. ammonium ferrous sulfate 8-11 interleukin 18 Homo sapiens 58-63 11123287-7 2001 Ab against the IL-18R alpha chain, however, prevented IL-18 responsiveness in COS-1 cells transfected with the IL-18R beta chain, suggesting that both chains be functional. carbonyl sulfide 78-81 interleukin 18 Homo sapiens 15-20 11056157-0 2001 ATP-stimulated release of interleukin (IL)-1beta and IL-18 requires priming by lipopolysaccharide and is independent of caspase-1 cleavage. Adenosine Triphosphate 0-3 interleukin 18 Homo sapiens 53-58 11056157-5 2001 Despite its constitutive cytosolic presence, IL-18 required lipopolysaccharide priming for the ATP-induced release. Adenosine Triphosphate 95-98 interleukin 18 Homo sapiens 45-50 11056157-8 2001 In evaluating the signaling components involved in the ATP effect, we identified that the protein-tyrosine kinase inhibitor, AG126, produced a profound inhibition of both ICE activation as well as release of IL-1beta/IL-18. Adenosine Triphosphate 55-58 interleukin 18 Homo sapiens 217-222 11056157-8 2001 In evaluating the signaling components involved in the ATP effect, we identified that the protein-tyrosine kinase inhibitor, AG126, produced a profound inhibition of both ICE activation as well as release of IL-1beta/IL-18. AG 127 125-130 interleukin 18 Homo sapiens 217-222 11056157-9 2001 Taken together, these results suggest that, although synthesis of IL-1beta and IL-18 differ, ATP-mediated release of both cytokines requires a priming step but not proteolytically functional caspase-1. Adenosine Triphosphate 93-96 interleukin 18 Homo sapiens 79-84 11174201-2 2001 Recently, it was reported that histamine induced IL-18 and that IL-18 might act as a coinducer of TH1 and TH2 cytokines. Histamine 31-40 interleukin 18 Homo sapiens 49-54 11174201-2 2001 Recently, it was reported that histamine induced IL-18 and that IL-18 might act as a coinducer of TH1 and TH2 cytokines. Histamine 31-40 interleukin 18 Homo sapiens 64-69 11175814-1 2001 Interleukin-12 (IL-12) and IL-18 induce synergistic transcription of interferon gamma (IFN-gamma) that is T cell receptor (TCR)-independent, not inhibited by cyclosporin A and requires new protein synthesis. Cyclosporine 158-171 interleukin 18 Homo sapiens 27-32 11292528-4 2001 Porcine IL-18 retains the caspase-1 cleavage site present in other mammalian IL-18 proteins, but has two potential N-linked glycosylation sites not found in those proteins. Nitrogen 115-116 interleukin 18 Homo sapiens 8-13 11581570-10 2001 According to the current model, the specific cellular recognition of agonistic LPS/lipid A is initialized by the combined extracellular actions of LPS binding protein (LBP), the membrane-bound or soluble forms of CD14 and the newly identified Toll-like receptor 4 (TLR4)*MD-2 complex, leading to the rapid activation of an intracellular signaling network that is highly homologous to the signaling systems of IL-1 and IL-18. Lipid A 83-90 interleukin 18 Homo sapiens 418-423 11069843-7 2000 The patients positive for gallium-67 ((67)Ga) scan had significantly elevated serum IL-18 levels as compared with those of the negative patients. Gallium 26-33 interleukin 18 Homo sapiens 84-89 12040407-0 2001 Asp(126), Asp(130) and Asp(134) are Necessary for Human IL-18 to Elicit IFN-gamma Production from PBMC. Aspartic Acid 0-3 interleukin 18 Homo sapiens 56-61 12040407-0 2001 Asp(126), Asp(130) and Asp(134) are Necessary for Human IL-18 to Elicit IFN-gamma Production from PBMC. Aspartic Acid 10-13 interleukin 18 Homo sapiens 56-61 12040407-0 2001 Asp(126), Asp(130) and Asp(134) are Necessary for Human IL-18 to Elicit IFN-gamma Production from PBMC. Aspartic Acid 10-13 interleukin 18 Homo sapiens 56-61 12040407-1 2001 To identify the amino acid residues which are critical to interleukin 18 (IL-18) function, three highly-conserved amino acids (Asp(126), Asp(130) and Asp(134)) were mutated to Asn, Lys and Lys. Aspartic Acid 127-130 interleukin 18 Homo sapiens 58-72 12040407-1 2001 To identify the amino acid residues which are critical to interleukin 18 (IL-18) function, three highly-conserved amino acids (Asp(126), Asp(130) and Asp(134)) were mutated to Asn, Lys and Lys. Aspartic Acid 127-130 interleukin 18 Homo sapiens 74-79 12040407-1 2001 To identify the amino acid residues which are critical to interleukin 18 (IL-18) function, three highly-conserved amino acids (Asp(126), Asp(130) and Asp(134)) were mutated to Asn, Lys and Lys. Aspartic Acid 137-140 interleukin 18 Homo sapiens 74-79 12040407-1 2001 To identify the amino acid residues which are critical to interleukin 18 (IL-18) function, three highly-conserved amino acids (Asp(126), Asp(130) and Asp(134)) were mutated to Asn, Lys and Lys. Aspartic Acid 137-140 interleukin 18 Homo sapiens 74-79 12040407-1 2001 To identify the amino acid residues which are critical to interleukin 18 (IL-18) function, three highly-conserved amino acids (Asp(126), Asp(130) and Asp(134)) were mutated to Asn, Lys and Lys. Asparagine 176-179 interleukin 18 Homo sapiens 74-79 12889520-2 2001 The IL-18 levels were also significantly correlated with the serum tumor necrosis factor alpha (TNF-alpha) and bilirubin levels. Bilirubin 111-120 interleukin 18 Homo sapiens 4-9 11061569-1 2000 Tacrolimus (FK-506) and cyclosporin A (CsA) are calcineurin antagonists used widely as T-cell immunosuppressants; however, their relative efficacy on the production of interleukin-18 (IL-18) remains undefined. Tacrolimus 0-10 interleukin 18 Homo sapiens 168-182 11091279-8 2000 Moreover, serum IL-18 levels in primary biliary cirrhosis were correlated with serum bilirubin concentrations and the Risk scores of the Mayo Clinic prognostic model for the disease. Bilirubin 85-94 interleukin 18 Homo sapiens 16-21 11035104-0 2000 ATP acts as an agonist to promote stimulus-induced secretion of IL-1 beta and IL-18 in human blood. Adenosine Triphosphate 0-3 interleukin 18 Homo sapiens 78-83 11035104-8 2000 Blood samples treated with ATP also demonstrated enhanced IL-18 production, but TNF-alpha levels decreased. Adenosine Triphosphate 27-30 interleukin 18 Homo sapiens 58-63 11061569-1 2000 Tacrolimus (FK-506) and cyclosporin A (CsA) are calcineurin antagonists used widely as T-cell immunosuppressants; however, their relative efficacy on the production of interleukin-18 (IL-18) remains undefined. Tacrolimus 0-10 interleukin 18 Homo sapiens 184-189 11061569-1 2000 Tacrolimus (FK-506) and cyclosporin A (CsA) are calcineurin antagonists used widely as T-cell immunosuppressants; however, their relative efficacy on the production of interleukin-18 (IL-18) remains undefined. Tacrolimus 12-18 interleukin 18 Homo sapiens 168-182 11061569-1 2000 Tacrolimus (FK-506) and cyclosporin A (CsA) are calcineurin antagonists used widely as T-cell immunosuppressants; however, their relative efficacy on the production of interleukin-18 (IL-18) remains undefined. Tacrolimus 12-18 interleukin 18 Homo sapiens 184-189 11061569-1 2000 Tacrolimus (FK-506) and cyclosporin A (CsA) are calcineurin antagonists used widely as T-cell immunosuppressants; however, their relative efficacy on the production of interleukin-18 (IL-18) remains undefined. Cyclosporine 24-37 interleukin 18 Homo sapiens 168-182 11061569-1 2000 Tacrolimus (FK-506) and cyclosporin A (CsA) are calcineurin antagonists used widely as T-cell immunosuppressants; however, their relative efficacy on the production of interleukin-18 (IL-18) remains undefined. Cyclosporine 24-37 interleukin 18 Homo sapiens 184-189 11061569-1 2000 Tacrolimus (FK-506) and cyclosporin A (CsA) are calcineurin antagonists used widely as T-cell immunosuppressants; however, their relative efficacy on the production of interleukin-18 (IL-18) remains undefined. Cyclosporine 39-42 interleukin 18 Homo sapiens 168-182 11061569-1 2000 Tacrolimus (FK-506) and cyclosporin A (CsA) are calcineurin antagonists used widely as T-cell immunosuppressants; however, their relative efficacy on the production of interleukin-18 (IL-18) remains undefined. Cyclosporine 39-42 interleukin 18 Homo sapiens 184-189 11007972-3 2000 Exocytosis of secretory lysosomes is modulated by calcium: in agreement with this, calcium influx results in secretion of pro-interleukin-18. Calcium 50-57 interleukin 18 Homo sapiens 126-140 11023667-8 2000 The GST-pro-IL-18 fusion protein was expressed in E. coli, captured on glutathione agarose and mature human IL-18, exhibiting high biological activity was released upon cleavage with factor Xa. glutathione agarose 71-90 interleukin 18 Homo sapiens 12-17 11023668-4 2000 Interestingly, the increase in the plasma IL-18 concentration was correlated with that in serum bilirubin levels in hepatectomized patients. Bilirubin 96-105 interleukin 18 Homo sapiens 42-47 11007972-3 2000 Exocytosis of secretory lysosomes is modulated by calcium: in agreement with this, calcium influx results in secretion of pro-interleukin-18. Calcium 83-90 interleukin 18 Homo sapiens 126-140 11007972-4 2000 In turn, pro-interleukin-18 secretion induced by T cells is prevented by the calcium channel blocker nifedipine. Nifedipine 101-111 interleukin 18 Homo sapiens 13-27 11007972-5 2000 Our results demonstrate a novel, calcium-mediated mechanism of post-translational regulation of secretion for interleukin-18, that allows a fast release of the cytokine. Calcium 33-40 interleukin 18 Homo sapiens 110-124 11022121-0 2000 A short course of oral aspirin increases IL-18-induced interferon-gamma production in whole blood cultures. Aspirin 23-30 interleukin 18 Homo sapiens 41-46 11022121-2 2000 Four days after cessation of a 3-day regimen of 650 mg of oral aspirin, there was a 70% increase in interferon-gamma (IFN-gamma) production, stimulated by a combination of interleukin-18 (IL-18) plus lipopolysaccharide (p < 0.05). Aspirin 63-70 interleukin 18 Homo sapiens 172-186 11022121-2 2000 Four days after cessation of a 3-day regimen of 650 mg of oral aspirin, there was a 70% increase in interferon-gamma (IFN-gamma) production, stimulated by a combination of interleukin-18 (IL-18) plus lipopolysaccharide (p < 0.05). Aspirin 63-70 interleukin 18 Homo sapiens 188-193 11041460-3 2000 The serum IL-18 levels in Graves" disease were significantly increased in the hyperthyroid state and were decreased during treatment with methimazole or propylthiouracil. Methimazole 138-149 interleukin 18 Homo sapiens 10-15 10996021-0 2000 Antisense IRAK-1 oligonucleotide blocks activation of NF-kappa B and AP-1 induced by IL-18. Oligonucleotides 17-32 interleukin 18 Homo sapiens 85-90 10996021-4 2000 The purpose of this study is to investigate the effects of preventing IRAK-1 expression by antisense IRAK-1 oligodeoxynucleotide (ODN) on IL-18-stimulated activation of NF-kappaB and AP-1. Oligodeoxyribonucleotides 108-128 interleukin 18 Homo sapiens 138-143 10996021-4 2000 The purpose of this study is to investigate the effects of preventing IRAK-1 expression by antisense IRAK-1 oligodeoxynucleotide (ODN) on IL-18-stimulated activation of NF-kappaB and AP-1. Oligodeoxyribonucleotides 130-133 interleukin 18 Homo sapiens 138-143 11028539-5 2000 In contrast, in whole blood from septic patients significantly elevated basal level of IL-18 were found, which could neither be further increased by LPS or SAC, nor be inhibited by Z-VAD. z-vad 181-186 interleukin 18 Homo sapiens 87-92 11041460-3 2000 The serum IL-18 levels in Graves" disease were significantly increased in the hyperthyroid state and were decreased during treatment with methimazole or propylthiouracil. Propylthiouracil 153-169 interleukin 18 Homo sapiens 10-15 11041460-5 2000 When liothyronine sodium was administered orally to healthy subjects, serum IL-18 levels were not changed. Triiodothyronine 5-24 interleukin 18 Homo sapiens 76-81 10951141-5 2000 RESULTS: The IL-18 gene was constitutively transcribed by primary human keratinocytes and cell lines and was not significantly altered following exposure to IL-1 beta, tumour necrosis factor-alpha, interferon (IFN)-gamma, phorbol myristate acetate or nickel sulphate. Tetradecanoylphorbol Acetate 222-247 interleukin 18 Homo sapiens 13-18 10951141-5 2000 RESULTS: The IL-18 gene was constitutively transcribed by primary human keratinocytes and cell lines and was not significantly altered following exposure to IL-1 beta, tumour necrosis factor-alpha, interferon (IFN)-gamma, phorbol myristate acetate or nickel sulphate. nickel sulfate 251-266 interleukin 18 Homo sapiens 13-18 10903731-1 2000 IL-18 is a regulator of NK cell function which utilizes the serine-threonine IL-1R-associated kinase signal transduction pathway and may activate additional not yet characterized signaling pathways. Serine 60-66 interleukin 18 Homo sapiens 0-5 10903731-1 2000 IL-18 is a regulator of NK cell function which utilizes the serine-threonine IL-1R-associated kinase signal transduction pathway and may activate additional not yet characterized signaling pathways. Threonine 67-76 interleukin 18 Homo sapiens 0-5 10903731-4 2000 Stimulation by IL-18 strongly enhanced tyrosine phosphorylation of STAT3 and of the mitogen-activated protein kinases (MAPK) p44erk-1and p42erk-2. Tyrosine 39-47 interleukin 18 Homo sapiens 15-20 10843724-5 2000 The EC50 values of histamine, 4-methylhistamine, and dimaprit for the production of IL-18 were 1.5, 1.0, and 3.8 microM, respectively. Histamine 19-28 interleukin 18 Homo sapiens 84-89 10912852-7 2000 Z-VAD and to a lesser degree Z-DEVD decreased (p < 0.05) S. aureus Cowan strain I-induced secretion of IL-18 into whole blood from control subjects and trauma patients. z-vad 0-5 interleukin 18 Homo sapiens 106-111 10912852-7 2000 Z-VAD and to a lesser degree Z-DEVD decreased (p < 0.05) S. aureus Cowan strain I-induced secretion of IL-18 into whole blood from control subjects and trauma patients. z-devd 29-35 interleukin 18 Homo sapiens 106-111 10901174-5 2000 The cloned IL-18 was expressed in Escherichia coli and its expression was confirmed by SDS-PAGE and Western blotting. Sodium Dodecyl Sulfate 87-90 interleukin 18 Homo sapiens 11-16 10843724-0 2000 Histamine is a potent inducer of IL-18 and IFN-gamma in human peripheral blood mononuclear cells. Histamine 0-9 interleukin 18 Homo sapiens 33-38 10843724-1 2000 Histamine (10-7 to 10-4 M) concentration-dependently stimulated the production of IL-18 and IFN-gamma and inhibited the production of IL-2 and IL-10 in human PBMCs. Histamine 0-9 interleukin 18 Homo sapiens 82-87 10843724-5 2000 The EC50 values of histamine, 4-methylhistamine, and dimaprit for the production of IL-18 were 1.5, 1.0, and 3.8 microM, respectively. 4-methylhistamine 30-47 interleukin 18 Homo sapiens 84-89 10843724-5 2000 The EC50 values of histamine, 4-methylhistamine, and dimaprit for the production of IL-18 were 1.5, 1.0, and 3.8 microM, respectively. Dimaprit 53-61 interleukin 18 Homo sapiens 84-89 10843724-7 2000 All effects of histamine on cytokine responses were also abolished by the presence of either anti-IL-18 Ab or IL-1beta-converting enzyme/caspase-1 inhibitor, indicating that the histamine action is dependent on mature IL-18 secretion and that IL-18 production is located upstream of the cytokine cascade activated by histamine. Histamine 15-24 interleukin 18 Homo sapiens 98-103 10843724-7 2000 All effects of histamine on cytokine responses were also abolished by the presence of either anti-IL-18 Ab or IL-1beta-converting enzyme/caspase-1 inhibitor, indicating that the histamine action is dependent on mature IL-18 secretion and that IL-18 production is located upstream of the cytokine cascade activated by histamine. Histamine 15-24 interleukin 18 Homo sapiens 218-223 10843724-7 2000 All effects of histamine on cytokine responses were also abolished by the presence of either anti-IL-18 Ab or IL-1beta-converting enzyme/caspase-1 inhibitor, indicating that the histamine action is dependent on mature IL-18 secretion and that IL-18 production is located upstream of the cytokine cascade activated by histamine. Histamine 15-24 interleukin 18 Homo sapiens 218-223 10843724-7 2000 All effects of histamine on cytokine responses were also abolished by the presence of either anti-IL-18 Ab or IL-1beta-converting enzyme/caspase-1 inhibitor, indicating that the histamine action is dependent on mature IL-18 secretion and that IL-18 production is located upstream of the cytokine cascade activated by histamine. Histamine 178-187 interleukin 18 Homo sapiens 98-103 10843724-7 2000 All effects of histamine on cytokine responses were also abolished by the presence of either anti-IL-18 Ab or IL-1beta-converting enzyme/caspase-1 inhibitor, indicating that the histamine action is dependent on mature IL-18 secretion and that IL-18 production is located upstream of the cytokine cascade activated by histamine. Histamine 178-187 interleukin 18 Homo sapiens 218-223 10843724-7 2000 All effects of histamine on cytokine responses were also abolished by the presence of either anti-IL-18 Ab or IL-1beta-converting enzyme/caspase-1 inhibitor, indicating that the histamine action is dependent on mature IL-18 secretion and that IL-18 production is located upstream of the cytokine cascade activated by histamine. Histamine 178-187 interleukin 18 Homo sapiens 218-223 10843724-9 2000 IFN-gamma production induced by IL-18 was inhibited by anti-IL-12 Ab, showing the marked contrast of the effect of histamine. Histamine 115-124 interleukin 18 Homo sapiens 32-37 10843724-10 2000 Thus histamine is a very important modulator of Th1 cytokine production in PBMCs and is quite unique in triggering IL-18-initiating cytokine cascade without inducing IL-12 production. Histamine 5-14 interleukin 18 Homo sapiens 115-120 10806046-0 2000 Diacerhein and rhein reduce the ICE-induced IL-1beta and IL-18 activation in human osteoarthritic cartilage. diacerein 0-10 interleukin 18 Homo sapiens 57-62 10880834-3 2000 In the present study, we show that even minor contamination with lymphoid cells of a pure population of macrophage-like cells (Raw 264.7) results in a marked production of nitric oxide after stimulation with both IL-12 and IL-18. Nitric Oxide 172-184 interleukin 18 Homo sapiens 223-228 10839541-7 2000 Acetylcholine, the principle vagal neurotransmitter, significantly attenuated the release of cytokines (tumour necrosis factor (TNF), interleukin (IL)-1beta, IL-6 and IL-18), but not the anti-inflammatory cytokine IL-10, in lipopolysaccharide-stimulated human macrophage cultures. Acetylcholine 0-13 interleukin 18 Homo sapiens 167-172 11324459-1 2000 AIM: To investigate whether phosphatidylinositol (PI) 3-kinase is involved in interleukin-18 (IL-18)-induced nuclear factor-kappa B (NF-kappa B) activation. Phosphatidylinositols 28-48 interleukin 18 Homo sapiens 78-92 11324459-1 2000 AIM: To investigate whether phosphatidylinositol (PI) 3-kinase is involved in interleukin-18 (IL-18)-induced nuclear factor-kappa B (NF-kappa B) activation. Phosphatidylinositols 28-48 interleukin 18 Homo sapiens 94-99 10571732-0 1999 Human keratinocytes constitutively express interleukin-18 and secrete biologically active interleukin-18 after treatment with pro-inflammatory mediators and dinitrochlorobenzene. Dinitrochlorobenzene 157-177 interleukin 18 Homo sapiens 43-57 10632669-8 2000 Changes in IL-18 mRNA expression correlated inversely with serum values for human choriogonadotropin (HCG) and IL-10 serum levels correlated with increases in serum 17beta-oestradiol levels. Estradiol 165-182 interleukin 18 Homo sapiens 11-16 10681439-2 2000 Because of these similarities, IL-18 was investigated for its ability to induce prostaglandin E(2) (PGE(2)) synthesis in human peripheral blood mononuclear cells (PBMC), a prominent, proinflammatory property of IL-1. Dinoprostone 80-98 interleukin 18 Homo sapiens 31-36 10681439-2 2000 Because of these similarities, IL-18 was investigated for its ability to induce prostaglandin E(2) (PGE(2)) synthesis in human peripheral blood mononuclear cells (PBMC), a prominent, proinflammatory property of IL-1. Dinoprostone 100-106 interleukin 18 Homo sapiens 31-36 10681439-5 2000 Although IL-1beta-induced IL-8 synthesis was augmented 3-fold by IL-18, IL-18 suppressed IL-1beta-induced PGE(2) production by 40%. Prostaglandins E 106-109 interleukin 18 Homo sapiens 72-77 10681439-6 2000 The suppressive effect of IL-18 on PGE(2) production was mediated by interferon (IFN)-gamma because anti-human IFN-gamma-antibody prevented IL-18-induced reduction in PGE(2). Prostaglandins E 35-38 interleukin 18 Homo sapiens 26-31 10681439-6 2000 The suppressive effect of IL-18 on PGE(2) production was mediated by interferon (IFN)-gamma because anti-human IFN-gamma-antibody prevented IL-18-induced reduction in PGE(2). Prostaglandins E 35-38 interleukin 18 Homo sapiens 140-145 10681439-6 2000 The suppressive effect of IL-18 on PGE(2) production was mediated by interferon (IFN)-gamma because anti-human IFN-gamma-antibody prevented IL-18-induced reduction in PGE(2). Prostaglandins E 167-170 interleukin 18 Homo sapiens 26-31 10681439-6 2000 The suppressive effect of IL-18 on PGE(2) production was mediated by interferon (IFN)-gamma because anti-human IFN-gamma-antibody prevented IL-18-induced reduction in PGE(2). Prostaglandins E 167-170 interleukin 18 Homo sapiens 140-145 10644334-2 2000 We found that infection with SIVmac251 induced the sequential production of interferon-alpha/beta (IFN-alpha/beta), IL-18, and IL-12. sivmac251 29-38 interleukin 18 Homo sapiens 116-121 10571732-6 1999 Human keratinocyte-secreted interleukin-18 is biologically active, in that conditioned media from phorbol 12-myrisate 13-acetate, lipopolysaccharide and DNCB-treated human keratinocytes induce interferon-gamma expression by peripheral blood mononuclear cells. phorbol 12-myrisate 13-acetate 98-128 interleukin 18 Homo sapiens 28-42 10571732-6 1999 Human keratinocyte-secreted interleukin-18 is biologically active, in that conditioned media from phorbol 12-myrisate 13-acetate, lipopolysaccharide and DNCB-treated human keratinocytes induce interferon-gamma expression by peripheral blood mononuclear cells. Dinitrochlorobenzene 153-157 interleukin 18 Homo sapiens 28-42 10571732-0 1999 Human keratinocytes constitutively express interleukin-18 and secrete biologically active interleukin-18 after treatment with pro-inflammatory mediators and dinitrochlorobenzene. Dinitrochlorobenzene 157-177 interleukin 18 Homo sapiens 90-104 10571732-5 1999 Exposure of human keratinocytes to phorbol 12-myrisate 13-acetate, lipopolysaccharides or the contact sensitizer DNCB results in the secretion of immunoprecipitable interleukin-18 protein. phorbol 12-myrisate 13-acetate 35-65 interleukin 18 Homo sapiens 165-179 10571732-5 1999 Exposure of human keratinocytes to phorbol 12-myrisate 13-acetate, lipopolysaccharides or the contact sensitizer DNCB results in the secretion of immunoprecipitable interleukin-18 protein. Dinitrochlorobenzene 113-117 interleukin 18 Homo sapiens 165-179 9890714-7 1998 The inhibitory efficiency of 117-10C was found to be 6-fold that of scFv in an interferon gamma (IFN-gamma)-inducing assay on the IL-18-responsive cell line KG-1. 117-10c 29-36 interleukin 18 Homo sapiens 130-135 10460493-5 1999 The enhanced interleukin-18 production was also observed when mannitol was replaced with NaCl as the inducer of hyperosmotic stress. Mannitol 62-70 interleukin 18 Homo sapiens 13-27 10460493-5 1999 The enhanced interleukin-18 production was also observed when mannitol was replaced with NaCl as the inducer of hyperosmotic stress. Sodium Chloride 89-93 interleukin 18 Homo sapiens 13-27 10352304-3 1999 Using a semiquantitative RT-PCR protocol, IL-18 mRNA transcripts were found to be increased in freshly isolated intestinal epithelial cells (IEC) and lamina propria mononuclear cells (LPMC) from CD compared with ulcerative colitis (UC) and noninflamed control (cont) patients, and were more abundant in IEC compared with LPMC. lpmc 184-188 interleukin 18 Homo sapiens 42-47 10352304-4 1999 Immunohistochemical analysis of surgically resected colonic tissues localized IL-18 to both LPMC (specifically, macrophages and dendritic cells) as well as IEC. lpmc 92-96 interleukin 18 Homo sapiens 78-83 9916738-5 1999 Studies on IL-18 effects on chondrocytes showed that it inhibits TGF-beta-induced proliferation and enhances nitric oxide production. Nitric Oxide 109-121 interleukin 18 Homo sapiens 11-16 9916738-8 1999 Treatment of normal human articular cartilage with IL-18 increased the release of glycosaminoglycans. Glycosaminoglycans 82-100 interleukin 18 Homo sapiens 51-56 9884348-6 1999 Finally, unlike IL-12 p40 mRNA, the constitutive accumulation of IL-18 transcripts by unstimulated cells was amplified in the presence of the translational blocker cycloheximide, which also caused a superinduction of IL-18 expression after Staphylococcus aureus stimulation. Cycloheximide 164-177 interleukin 18 Homo sapiens 65-70 9884348-6 1999 Finally, unlike IL-12 p40 mRNA, the constitutive accumulation of IL-18 transcripts by unstimulated cells was amplified in the presence of the translational blocker cycloheximide, which also caused a superinduction of IL-18 expression after Staphylococcus aureus stimulation. Cycloheximide 164-177 interleukin 18 Homo sapiens 217-222 10613507-2 1999 We found that bilateral ibotenic acid lesions of the central amygdala substantially reduced adrenocorticotropin hormone release and hypothalamic corticotropin-releasing factor and oxytocin cell c-fos expression responses to interleukin-1,8 suggesting a facilitatory role for this structure in the generation of hypothalamic-pituitary-adrenal axis responses to an immune challenge. Ibotenic Acid 24-37 interleukin 18 Homo sapiens 224-239 10427997-0 1999 Oligodeoxynucleotides containing CpG motifs induce IL-12, IL-18 and IFN-gamma production in cells from allergic individuals and inhibit IgE synthesis in vitro. Oligodeoxyribonucleotides 0-21 interleukin 18 Homo sapiens 58-63 10384110-11 1999 To confirm that IL-18 produced in CD tissue was functionally active, CD LPMC were treated with a specific IL-18 antisense oligonucleotide. cd lpmc 69-76 interleukin 18 Homo sapiens 16-21 10384110-11 1999 To confirm that IL-18 produced in CD tissue was functionally active, CD LPMC were treated with a specific IL-18 antisense oligonucleotide. cd lpmc 69-76 interleukin 18 Homo sapiens 106-111 10384110-11 1999 To confirm that IL-18 produced in CD tissue was functionally active, CD LPMC were treated with a specific IL-18 antisense oligonucleotide. Oligonucleotides 122-137 interleukin 18 Homo sapiens 16-21 10384110-11 1999 To confirm that IL-18 produced in CD tissue was functionally active, CD LPMC were treated with a specific IL-18 antisense oligonucleotide. Oligonucleotides 122-137 interleukin 18 Homo sapiens 106-111 9334240-3 1997 To clarify this, we purified natural hIL-18 from the cytosolic extract of monocytic THP.1 cells. pirarubicin 84-87 interleukin 18 Homo sapiens 37-43 9780184-7 1998 The NO donor S-nitroso-N-acetyl-DL-penicillamine inhibited caspase-1 activity in cells as well as the activity of purified recombinant caspase-1 and also prevented the cleavage of pro-IL-1beta and pro-IGIF by recombinant caspase-1. snap 13-48 interleukin 18 Homo sapiens 201-205 9558078-6 1998 Cultures of T cells with anti-CD3/anti-CD28 in the presence of rIL-12 induced IL-18R expression and IL-18-stimulated IFN-gamma production, which reached higher levels than that induced by IL-12 stimulation. ril-12 63-69 interleukin 18 Homo sapiens 78-83 9917859-5 1998 IL-18 is also initially synthesized as an inactive precursor molecule (proIL-18) lacking a signal peptide. proil 71-76 interleukin 18 Homo sapiens 0-5 9917859-6 1998 IL-18 is a member of the IL-1 family, and like IL-1 beta, proIL-18 is cleaved by ICE to yield an active molecule. proil 58-63 interleukin 18 Homo sapiens 0-5 9413156-1 1997 Interleukin-18 (IL-18) induces apoptosis in human myelomonocytic KG-1 cells as determined by agarose gel electrophoresis, and flow cytometry after propidium iodide (PI) staining. Sepharose 93-100 interleukin 18 Homo sapiens 0-14 9413156-1 1997 Interleukin-18 (IL-18) induces apoptosis in human myelomonocytic KG-1 cells as determined by agarose gel electrophoresis, and flow cytometry after propidium iodide (PI) staining. Sepharose 93-100 interleukin 18 Homo sapiens 16-21 9413156-1 1997 Interleukin-18 (IL-18) induces apoptosis in human myelomonocytic KG-1 cells as determined by agarose gel electrophoresis, and flow cytometry after propidium iodide (PI) staining. Propidium 147-163 interleukin 18 Homo sapiens 0-14 9413156-1 1997 Interleukin-18 (IL-18) induces apoptosis in human myelomonocytic KG-1 cells as determined by agarose gel electrophoresis, and flow cytometry after propidium iodide (PI) staining. Propidium 147-163 interleukin 18 Homo sapiens 16-21 34875574-8 2022 LPS, PGN, and MDP induced FM IL-1beta and IL-18 secretion in a non-pyroptotic manner through activation of the NLRP3 inflammasome with contributions from ATP release through Pannexin-1, and ROS signaling. Acetylmuramyl-Alanyl-Isoglutamine 14-17 interleukin 18 Homo sapiens 42-47 33760701-4 2021 Recent studies indicate that tetracycline can be used to treat inflammatory diseases mediated by IL-1beta and IL-18 while the molecular mechanism by which tetracycline inhibits inflammasome-caspase-1 signaling remains unknown. Tetracycline 29-41 interleukin 18 Homo sapiens 110-115 34766707-3 2022 We isolated primary AEC from three healthy adults and treated them with silica particles at different concentrations for 48 h. We found evidence for silica-induced inflammasome activation by the co-localization of Caspase-1 and NLRP3, as well as increased levels of IL-1beta and IL-18. Silicon Dioxide 72-78 interleukin 18 Homo sapiens 279-284 34766707-3 2022 We isolated primary AEC from three healthy adults and treated them with silica particles at different concentrations for 48 h. We found evidence for silica-induced inflammasome activation by the co-localization of Caspase-1 and NLRP3, as well as increased levels of IL-1beta and IL-18. Silicon Dioxide 149-155 interleukin 18 Homo sapiens 279-284 34547334-11 2022 CONCLUSIONS: Urine NGAL, KIM-1, and IL-18 were elevated in neonates with HIE receiving TH who developed AKI. Thorium 87-89 interleukin 18 Homo sapiens 36-41 33760701-10 2021 In experimental ALI, tetracycline significantly diminished lung injury and pulmonary inflammation by selectively inhibiting caspase-1-dependent IL-1beta and IL-18 production leading to improved survival. Tetracycline 21-33 interleukin 18 Homo sapiens 157-162 33760701-11 2021 Tetracycline also reduced the production of IL-1beta and IL-18 by alveolar leucocytes from patients with direct ARDS. Tetracycline 0-12 interleukin 18 Homo sapiens 57-62 34875574-8 2022 LPS, PGN, and MDP induced FM IL-1beta and IL-18 secretion in a non-pyroptotic manner through activation of the NLRP3 inflammasome with contributions from ATP release through Pannexin-1, and ROS signaling. Adenosine Triphosphate 154-157 interleukin 18 Homo sapiens 42-47 34875574-8 2022 LPS, PGN, and MDP induced FM IL-1beta and IL-18 secretion in a non-pyroptotic manner through activation of the NLRP3 inflammasome with contributions from ATP release through Pannexin-1, and ROS signaling. ros 190-193 interleukin 18 Homo sapiens 42-47 34432333-0 2022 Elevated serum levels of TNF-alpha, IL-6, and IL-18 in chronic methamphetamine users. Methamphetamine 63-78 interleukin 18 Homo sapiens 46-51 34415562-10 2022 RESULTS: We found that carbachol increased the expression of NLRP3 inflammasome (NLRP3, ASC, cleaved caspase-1, IL-1beta, and IL-18). Carbachol 23-32 interleukin 18 Homo sapiens 126-131 34904823-5 2022 PA treatment suppresses the nuclear translocation of NF-kappaB, enhances PARKIN translocation into the mitochondria, and maintains cellular redox homeostasis in both mouse and human microglial cells that limit NLRP3 inflammasome activation along with processing of active caspase-1, IL-1beta, and IL-18. perillyl alcohol 0-2 interleukin 18 Homo sapiens 297-302 34696918-7 2022 Treatment with H2O2 + VD decreased gene/protein expression of NLRP1, NLRP3, caspase-1, HMGB1, IL-1beta, TNF-alpha and IL-18 in PE and NT explants with H2O2. Hydrogen Peroxide 15-19 interleukin 18 Homo sapiens 118-123 34696918-7 2022 Treatment with H2O2 + VD decreased gene/protein expression of NLRP1, NLRP3, caspase-1, HMGB1, IL-1beta, TNF-alpha and IL-18 in PE and NT explants with H2O2. Hydrogen Peroxide 151-155 interleukin 18 Homo sapiens 118-123 34976136-13 2022 Notably, NaHS and L-cysteine significantly suppressed the expression levels of NLRP3 and cleaved caspase-1, and the production of IL-1 and IL-18 in human placental cells. sodium bisulfide 9-13 interleukin 18 Homo sapiens 139-144 34976136-13 2022 Notably, NaHS and L-cysteine significantly suppressed the expression levels of NLRP3 and cleaved caspase-1, and the production of IL-1 and IL-18 in human placental cells. Cysteine 18-28 interleukin 18 Homo sapiens 139-144 34432333-2 2022 Our aim was to analyze the serum levels of tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-6, and IL-18 in chronic methamphetamine users. Methamphetamine 125-140 interleukin 18 Homo sapiens 108-113 34432333-7 2022 RESULTS: Serum levels of TNF-alpha, IL-6, and IL-18 were significantly increased in methamphetamine users who did not continue methamphetamine exposure since hospital admission (average days since last methamphetamine use = 39.06 +- 7.48) when compared to those in controls. Methamphetamine 84-99 interleukin 18 Homo sapiens 46-51 34432333-7 2022 RESULTS: Serum levels of TNF-alpha, IL-6, and IL-18 were significantly increased in methamphetamine users who did not continue methamphetamine exposure since hospital admission (average days since last methamphetamine use = 39.06 +- 7.48) when compared to those in controls. Methamphetamine 202-217 interleukin 18 Homo sapiens 46-51 34432333-9 2022 CONCLUSIONS: Our results suggest that increased TNF-alpha, IL-6, and IL-18 levels may have an important role in chronic methamphetamine use-associated psychopathological symptoms. Methamphetamine 120-135 interleukin 18 Homo sapiens 69-74 34977008-7 2021 Results: Our results demonstrated that IL-18 increased calcium deposition in hBMSCs, and upregulated the expression of SLC7A5, c-MYC, ALP, RUNX2, and BMP2. Calcium 55-62 interleukin 18 Homo sapiens 39-44 34719371-5 2021 In particular, ALA is able to reduce inflammasome activity, the pro-inflammatory cytokine levels, such as TNF-alpha, IL-1beta, IL-6, IL-18 and IL-17, interferon (INF)-gamma as well as the production of Vascular and Intercellular cell adhesion protein (VCAM-1 and ICAM-1). Thioctic Acid 15-18 interleukin 18 Homo sapiens 133-138 34937520-6 2021 Compared to the NT group, the endogenous levels of IL-1beta, TNF-alpha, and IL-18 were higher in the PE group. nt 16-18 interleukin 18 Homo sapiens 76-81 34076913-6 2021 ELISA of BALF validated that ANI 654-2 decreased TNF-alpha, IL-1beta, IL-6 and IL-18 while increased IL-10. 1-Naphthylisothiocyanate 29-32 interleukin 18 Homo sapiens 79-84 34922061-9 2021 After anthocyanin administration, both mRNA expression of NLRP3 inflammasome components (caspase-1, IL-1beta, and IL-18) in PBMCs and plasma levels of IL-1beta and IL-18 decreased dramatically in NAFLD patients compared with controls. Anthocyanins 6-17 interleukin 18 Homo sapiens 114-119 34922061-9 2021 After anthocyanin administration, both mRNA expression of NLRP3 inflammasome components (caspase-1, IL-1beta, and IL-18) in PBMCs and plasma levels of IL-1beta and IL-18 decreased dramatically in NAFLD patients compared with controls. Anthocyanins 6-17 interleukin 18 Homo sapiens 164-169 34899969-0 2021 N-Acetylcysteine (NAC) Inhibits Synthesis of IL-18 in Macrophage by Suppressing NLRP3 Expression to Reduce the Production of IFN-gamma from NK Cells. Acetylcysteine 0-16 interleukin 18 Homo sapiens 45-50 34899969-0 2021 N-Acetylcysteine (NAC) Inhibits Synthesis of IL-18 in Macrophage by Suppressing NLRP3 Expression to Reduce the Production of IFN-gamma from NK Cells. Acetylcysteine 18-21 interleukin 18 Homo sapiens 45-50 34899969-3 2021 This study was designed to evaluate the specific mechanism of NAC regulating IL-18. Acetylcysteine 62-65 interleukin 18 Homo sapiens 77-82 34338149-7 2021 Furthermore, the activated NLRP3 inflammasome and the excessive production of interleukin 18 (IL-18) and interleukin 1beta (IL-1beta) in HrGECs induced by incubation with HG were pronouncedly reversed by the introduction of Omarigliptin, accompanied by the activation of the AMPK/mTOR signaling pathway. 2-(2,5-difluorophenyl)-5-(2-(methylsulfonyl)-2,6-dihydropyrrolo(3,4-c)pyrazol-5(4H)-yl)tetrahydro-2H-pyran-3-amine 224-236 interleukin 18 Homo sapiens 78-92 34338149-7 2021 Furthermore, the activated NLRP3 inflammasome and the excessive production of interleukin 18 (IL-18) and interleukin 1beta (IL-1beta) in HrGECs induced by incubation with HG were pronouncedly reversed by the introduction of Omarigliptin, accompanied by the activation of the AMPK/mTOR signaling pathway. 2-(2,5-difluorophenyl)-5-(2-(methylsulfonyl)-2,6-dihydropyrrolo(3,4-c)pyrazol-5(4H)-yl)tetrahydro-2H-pyran-3-amine 224-236 interleukin 18 Homo sapiens 94-99 34710506-5 2021 IFN-gamma (100 ng/mL) plus poly (dA:dT) (2 mg/mL) induced the increased AURKA, secretion of IL-1beta, IL-18 and the active form of caspase-1 (p20). poly(dA) 27-36 interleukin 18 Homo sapiens 102-107 34710506-5 2021 IFN-gamma (100 ng/mL) plus poly (dA:dT) (2 mg/mL) induced the increased AURKA, secretion of IL-1beta, IL-18 and the active form of caspase-1 (p20). Thymidine 36-39 interleukin 18 Homo sapiens 102-107 34794285-0 2021 Effects of S-adenosyl-L-Methionine Combined with Ursodesoxycholic Acid on Serum Endotoxin, MMP-9 and IL-18 in Neonates with Cholestasis. S-Adenosylmethionine 11-34 interleukin 18 Homo sapiens 101-106 34794285-0 2021 Effects of S-adenosyl-L-Methionine Combined with Ursodesoxycholic Acid on Serum Endotoxin, MMP-9 and IL-18 in Neonates with Cholestasis. Ursodeoxycholic Acid 49-70 interleukin 18 Homo sapiens 101-106 34794285-9 2021 CONCLUSION: Compared with UDCA alone, SAMe plus UDCA can more effectively improve the curative effect of neonatal cholestasis, and reduce serum endotoxin, MMP-9 and IL-18 levels. Ursodeoxycholic Acid 26-30 interleukin 18 Homo sapiens 165-170 34708887-7 2022 However, administration of NOX1/4 inhibitor GKT137831 alleviated PM2.5 -induced elevated endothelial dysfunction biomarkers (NO, ET-1, ADMA, iNOS, and tPA/PAI-1), inflammatory factors (IL-1beta, IL-10, and IL-18), and adhesion molecules (ICAM-1, VCAM-1, and P-selectin) and also passivated NOX-dependent AKT and eNOS phosphorylation that involved in endothelial activation. setanaxib 44-53 interleukin 18 Homo sapiens 206-211 34850023-6 2022 In comparison to controls, patients with CPA had significantly reduced production of IFNgamma in response to stimulation with beta-glucan+IL-12 (312 vs 988 pg/ml), LPS+IL-12 (252 vs 1033 pg/ml), ZYM+IL-12 (996 vs 2347 pg/ml), and IL-18+IL-12 (7193 vs 12330 pg/ml). cpa 41-44 interleukin 18 Homo sapiens 230-235 34643000-5 2021 CBD caused a parallel inhibition of interleukin 1 beta (IL-1beta), IL-6, tumor necrosis factor alpha (TNF-alpha), and IL-18 by enzyme-linked immunosorbent assay (ELISA) assay. Cannabidiol 0-3 interleukin 18 Homo sapiens 118-123 34293432-5 2021 Our results showed that LPC significantly increased the levels of inflammatory cytokines (IL-1beta, IL-18, and IL-33) and markedly induced apoptosis and NLRP3 inflammasome activation in BMECs. Lysophosphatidylcholines 24-27 interleukin 18 Homo sapiens 100-105 34899697-6 2021 Results: Both tetracyclines significantly decreased, in a dose dependent manner, IFN-gamma production in NKT and CD4+ T lymphocytes from MS patients (naive or treated) stimulated with IL-12/IL-18 but did not decrease IFN-gamma producing CD8+ T cells from naive MS or treated RRMS patients. Tetracyclines 14-27 interleukin 18 Homo sapiens 184-195 34933712-6 2021 Therefore, in the current study, the effect of borage oil was considered on the signaling pathway of the NLRP3 inflammasome complex, TLR4, and serum levels of inflammatory cytokines (IL-1? and IL-18) in type II diabetic patients with ARDS. borage oil 47-57 interleukin 18 Homo sapiens 193-198 34933712-9 2021 The expression of NLRP3 and TLR4 genes (by Real-time PCR technique) and serum levels of IL-1? and IL-18 (by ELISA test) were evaluated before and after treatment with borage oil through blood samples taken from patients. borage oil 167-177 interleukin 18 Homo sapiens 98-103 34933712-10 2021 The results showed that serum levels of inflammatory cytokines (IL-1? and IL-18), NLRP3 gene, and TLR4 gene were significantly decreased in diabetic type II patients with mild ARDS by treating with borage oil. borage oil 198-208 interleukin 18 Homo sapiens 74-79 34510229-5 2021 Results revealed that CdCl2 (2-8 muM) increased ROS production and activated NLRP3, thereby enhancing secretion of IL-1beta and IL-18 (P < 0.05). Cadmium Chloride 22-27 interleukin 18 Homo sapiens 128-133 34799399-16 2021 NIZ985 treatment was associated with increases in several cytokines, including interferon (IFN)-gamma, IL-18, C-X-C motif chemokine ligand 10, and tumor necrosis factor-beta, plus significant induction of cytotoxic lymphocyte proliferation (including natural killer and CD8+ T cells), increased CD16+ monocytes, and increased CD163+ macrophages at injection sites. niz985 0-6 interleukin 18 Homo sapiens 103-108 34717522-10 2021 Moreover, both TCR-dependent MAIT cell activation by microbial-derived riboflavin intermediates and TCR-independent MAIT cell activation driven by IL-18 in synergy with IL-12, were blocked by GSI treatment. 2-(5-Chlorothiophen-2-Yl)-N-[(3s)-1-(4-{2-[(Dimethylamino)methyl]-1h-Imidazol-1-Yl}-2-Fluorophenyl)-2-Oxopyrrolidin-3-Yl]ethanesulfonamide 192-195 interleukin 18 Homo sapiens 147-152 34755129-5 2021 Specifically, fibrosing cGVHD was associated with a distinct pathway shift toward anthranilic and kynurenic acid, correlating with reduced activity of the vitamin-B2-dependent kynurenine monooxygenase, low vitamin B6, and increased interleukin-18. Kynurenic Acid 98-112 interleukin 18 Homo sapiens 232-246 34768828-2 2021 Nucleotide-binding oligomerization domain (NOD)-Leucine-rich repeats (LRR)-containing receptors (NLRs), also called nucleotide-binding oligomerization (NOD)-like receptors (NLRs), are major cytosolic pattern recognition receptors (PRRs), their involvement in the orchestration of innate immunity and host defense against bacteria, viruses, fungi and parasites, often results in the cleavage of gasdermin and the release of IL-1beta and IL-18, should be tightly regulated. Leucine 48-55 interleukin 18 Homo sapiens 436-441 34831052-3 2021 One of these mechanisms is related to NLRP3 activation, initiated by high levels of danger signals such as cholesterol, urate, and glucose, producing IL-1, IL-18, and cell death by pyroptosis. Cholesterol 107-118 interleukin 18 Homo sapiens 156-161 34831052-3 2021 One of these mechanisms is related to NLRP3 activation, initiated by high levels of danger signals such as cholesterol, urate, and glucose, producing IL-1, IL-18, and cell death by pyroptosis. Uric Acid 120-125 interleukin 18 Homo sapiens 156-161 34831052-3 2021 One of these mechanisms is related to NLRP3 activation, initiated by high levels of danger signals such as cholesterol, urate, and glucose, producing IL-1, IL-18, and cell death by pyroptosis. Glucose 131-138 interleukin 18 Homo sapiens 156-161 34755662-9 2021 SX treatment (20 and 40 mg/L) and TGT treatment both significantly lowered the expression levels of TNF-alpha, IL-1beta, and IL-18 in the cells (P < 0.05). sx 0-2 interleukin 18 Homo sapiens 125-130 34681768-7 2021 BAY-117082 at higher concentrations significantly reduced NLRP3, ASC, caspase-1, IL-1beta, and IL-18 expression. 3-(4-methylphenylsulfonyl)-2-propenenitrile 0-10 interleukin 18 Homo sapiens 95-100 34733276-6 2021 Furthermore, we found significantly increased plasma levels of IL-6, IL-12, IL-17, IL-18, stem cell factor (SCF), and IL-21/IL-23 in SLE patients compared to healthy controls, and those levels positively correlated with the plasma levels of 17beta-estradiol. Estradiol 241-257 interleukin 18 Homo sapiens 83-88 34338401-10 2021 Additionally, exposure to nigericin sodium salt, an agonist of the NLRP3 inflammasome, upregulated expression of the NLRP3 inflammasome accompanied by the release of IL-1beta and IL-18. Nigericin sodium 26-47 interleukin 18 Homo sapiens 179-184 34229177-8 2021 Moreover, the ELISA results revealed that licochalcone E significantly reduced the expression of TNF-alpha, IL-1beta, and IL-18. licochalcone E 42-56 interleukin 18 Homo sapiens 122-127 34250720-9 2021 What is more, hypaphorine attenuated the expression of inflammatory factors (IL-1beta, IL-6, TNF-alpha, and IL-18) and inactivated the p38/JNK signaling pathway through upregulating DUSP1 in a dose-dependent manner. lenticin 14-25 interleukin 18 Homo sapiens 108-113 34738551-8 2021 All measurements were not significantly different between the nicorandil and conventional treatment groups before treatment (all P > 0.05), and BNP, Scr, Cys-C, NGAL, KIM-1, and IL-18 were decreased in the 2 groups at the end of treatment (all P < 0.05). Nicorandil 62-72 interleukin 18 Homo sapiens 178-183 34738551-9 2021 Compared with the conventional treatment group, BNP, Scr, Cys-C, NGAL, KIM-1, and IL-18 were more significantly decreased in the nicorandil group (all P < 0.05) and left ventricular ejection fraction was more significantly increased (P < 0.05). Nicorandil 129-139 interleukin 18 Homo sapiens 82-87 34596583-8 2021 The effects of IL-18 on the proliferation and type 2 cytokine production were detected by tritiated thymidine incorporation test, real-time PCR, and ELISA, respectively. Tritiated thymidine 90-109 interleukin 18 Homo sapiens 15-20 34596583-12 2021 The tritiated thymidine incorporation results showed that IL-18 promoted the proliferation of ILC2 in a dose-dependent manner. Thymidine 14-23 interleukin 18 Homo sapiens 58-63 34675809-7 2021 Notably, the increased expression levels of TLR4, NLRP3, interleukin 1beta, and interleukin 18 proteins and the elevated activities of caspase-1 and lactic dehydrogenase in in vivo and in vitro disease models were markedly reversed by the treatment with BHGZD. bhgzd 254-259 interleukin 18 Homo sapiens 80-94 34098069-5 2021 Elevated ROS and NLRP3, caspase-1, IL-1beta and IL-18 were detected, which was attenuated by N-acetylcysteine. Acetylcysteine 93-109 interleukin 18 Homo sapiens 48-53 34368883-10 2021 Concurrently, oxymatrine inhibited ox-LDL-induced NLRP3 inflammasome-mediated pyroptosis in HUVECs, as evidenced by the significant decreases in the expression of NLRP3, apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain (ASC), cleaved caspase-1, interleukin (IL)-1beta and IL-18 in HUVECs. oxymatrine 14-24 interleukin 18 Homo sapiens 314-319 34638670-12 2021 Significant increases in plasma and kidney IL-1beta and IL-18 in response to CLP were decreased with Clopidogrel treatment. Clopidogrel 101-112 interleukin 18 Homo sapiens 56-61 34630082-3 2021 Objective: The aim of this study was to evaluate the role of urinary IL-18, KIM-1, NGAL, TIMP-2, and IGFBP7 as diagnostic and prognostic predictors of AKI related to vancomycin. Vancomycin 166-176 interleukin 18 Homo sapiens 69-74 34489689-5 2021 The NACHT, leucine-rich repeat (LRR), and pyrin (PYD) domains-containing protein 3 (NLRP3) inflammasome regulates IL-1beta and IL-18 secretion and gasdermin D-mediated pyroptosis and plays a key role in innate immunity. Leucine 11-18 interleukin 18 Homo sapiens 127-132 34116285-9 2021 Lower serum IL-1beta levels were detected in the EAM + BBG group than in the EAM1 group (P < 0.05), and serum IL-1beta and IL-18 levels in the EAM + glyburide group were lower than those in the EAM2 group (P < 0.05). Glyburide 149-158 interleukin 18 Homo sapiens 123-128 34116285-9 2021 Lower serum IL-1beta levels were detected in the EAM + BBG group than in the EAM1 group (P < 0.05), and serum IL-1beta and IL-18 levels in the EAM + glyburide group were lower than those in the EAM2 group (P < 0.05). eam2 194-198 interleukin 18 Homo sapiens 123-128 34492927-5 2021 Besides, both 3-MA and CQ addition increased NLRP3, Caspase-1, NEK7, ASC, GSDMA, GSDME, IL-1beta, IL-18 mRNA levels, NLRP3, Caspase-1 p20, ASC, GSDMD protein and ROS levels, and NO, LDH, IL-1beta, IL-18 releases. 3-methyladenine 14-18 interleukin 18 Homo sapiens 98-103 34492927-5 2021 Besides, both 3-MA and CQ addition increased NLRP3, Caspase-1, NEK7, ASC, GSDMA, GSDME, IL-1beta, IL-18 mRNA levels, NLRP3, Caspase-1 p20, ASC, GSDMD protein and ROS levels, and NO, LDH, IL-1beta, IL-18 releases. 3-methyladenine 14-18 interleukin 18 Homo sapiens 197-202 34492927-5 2021 Besides, both 3-MA and CQ addition increased NLRP3, Caspase-1, NEK7, ASC, GSDMA, GSDME, IL-1beta, IL-18 mRNA levels, NLRP3, Caspase-1 p20, ASC, GSDMD protein and ROS levels, and NO, LDH, IL-1beta, IL-18 releases. Chloroquine 23-25 interleukin 18 Homo sapiens 98-103 34408814-2 2021 H2S has previously been shown to induce the secretion of the pro-inflammatory cytokines IL-1beta and IL-18 via the NLRP3 inflammasome in monocytes. Deuterium 0-3 interleukin 18 Homo sapiens 101-106 34492927-5 2021 Besides, both 3-MA and CQ addition increased NLRP3, Caspase-1, NEK7, ASC, GSDMA, GSDME, IL-1beta, IL-18 mRNA levels, NLRP3, Caspase-1 p20, ASC, GSDMD protein and ROS levels, and NO, LDH, IL-1beta, IL-18 releases. Chloroquine 23-25 interleukin 18 Homo sapiens 197-202 34452150-3 2021 5-FU activity leads to caspase-1 activation, secretion and maturation of interleukins (IL)-1, IL-18 and reactive oxygen species (ROS) generation. Fluorouracil 0-4 interleukin 18 Homo sapiens 94-99 34344968-5 2021 Moreover, IL-18 increased calcium influx into neutrophils, which led to mitochondrial ROS (mROS) production and NETs formation. Calcium 26-33 interleukin 18 Homo sapiens 10-15 34344968-5 2021 Moreover, IL-18 increased calcium influx into neutrophils, which led to mitochondrial ROS (mROS) production and NETs formation. ros 86-89 interleukin 18 Homo sapiens 10-15 34216617-4 2021 We found that antimycin A-induced mitochondrial dysfunction caused caspase-1-dependent inflammasome activation and subsequent production of mature IL-1beta and IL-18 in human RPE cells. Antimycin A 14-25 interleukin 18 Homo sapiens 160-165 34131437-8 2021 Moreover, knockdown of NLRC4 expression in HK2 cells treated with HG reduced the secretion of the inflammatory cytokines, IL-1beta and IL-18. Mercury 66-68 interleukin 18 Homo sapiens 135-140 34188699-5 2021 Compared with those in the vehicle (DMSO)-treated control cells, artesunate enhanced the apoptotic rate and increased lactate dehydrogenase release, reactive oxygen species and IL1b and IL18 levels in C918 cells. Dimethyl Sulfoxide 36-40 interleukin 18 Homo sapiens 186-190 34188699-5 2021 Compared with those in the vehicle (DMSO)-treated control cells, artesunate enhanced the apoptotic rate and increased lactate dehydrogenase release, reactive oxygen species and IL1b and IL18 levels in C918 cells. Artesunate 65-75 interleukin 18 Homo sapiens 186-190 34194747-6 2021 IL-18 function in epithelial cells was examined by intracellular calcium, wound repair, synthetic activation and epithelial differentiation changes. Calcium 65-72 interleukin 18 Homo sapiens 0-5 34322217-12 2021 Also, corneocyte IL-18 levels were significantly reduced after application of disulfiram compared to vehicle (p < 0.001). Disulfiram 78-88 interleukin 18 Homo sapiens 17-22 34263421-8 2022 In addition, significant difference was determined in terms of serum copper and zinc levels and copper/zinc ratio according to haplotypes of IL-18 (- 607 C/A), IL-18 (- 137 G/C), and MMP-2 (- 1306 C/T) gene variations between patient and control groups (p < 0.05). Copper 69-75 interleukin 18 Homo sapiens 141-146 34236821-8 2021 MiR-128-3p reduced inflammation factor levels (tumor necrosis factor alpha, interleukin (IL)-6, IL-1beta, and IL-18). mir-128-3p 0-10 interleukin 18 Homo sapiens 110-115 34276328-6 2021 It has been proposed that vagal efferent fibers release acetylcholine (Ach), which can interact with alpha7-subunit-containing nicotinic receptors expressed by tissue macrophages and other immune cells to rapidly inhibit the synthesis/release of pro-inflammatory cytokines such as TNFalpha, IL-1beta, IL-6, and IL-18. Acetylcholine 56-69 interleukin 18 Homo sapiens 311-316 34276328-6 2021 It has been proposed that vagal efferent fibers release acetylcholine (Ach), which can interact with alpha7-subunit-containing nicotinic receptors expressed by tissue macrophages and other immune cells to rapidly inhibit the synthesis/release of pro-inflammatory cytokines such as TNFalpha, IL-1beta, IL-6, and IL-18. Acetylcholine 71-74 interleukin 18 Homo sapiens 311-316 34263421-8 2022 In addition, significant difference was determined in terms of serum copper and zinc levels and copper/zinc ratio according to haplotypes of IL-18 (- 607 C/A), IL-18 (- 137 G/C), and MMP-2 (- 1306 C/T) gene variations between patient and control groups (p < 0.05). Copper 96-102 interleukin 18 Homo sapiens 141-146 34266494-7 2021 Further results showed that Rabeprazole inhibited cell pyroptosis in gastric epithelial cells by alleviating GSDMD-executed pyroptosis, leading to decrease IL-1beta and IL-18 mature and secretion, which is attributed to NLRP3 inflammasome activation inhibition. Rabeprazole 28-39 interleukin 18 Homo sapiens 169-174 34194747-11 2021 In vitro, IL-18-stimulated bronchial epithelial cells increased intracellular calcium, wound repair, metabolic activity, morphological changes and epithelial cellular differentiation. Calcium 78-85 interleukin 18 Homo sapiens 10-15 34204067-4 2021 In the present study, we investigated the propensity of hydroquinone to induce the secretion of interleukin (IL)-1beta and IL-18. hydroquinone 56-68 interleukin 18 Homo sapiens 123-128 34116684-9 2021 Functionally, overexpression of miR-24-3p significantly attenuated IL-1beta-induced chondrocyte injury, as reflected by increased cell viability, decreased caspase-3 activity, and pro-inflammatory cytokines (TNF-alpha and IL-18). mir-24-3p 32-41 interleukin 18 Homo sapiens 222-227 34204067-8 2021 Hydroquinone did not change IL-1beta release but significantly increased the secretion of IL-18. hydroquinone 0-12 interleukin 18 Homo sapiens 90-95 34204067-12 2021 In contrast, the NADPH oxidase inhibitor ammonium pyrrolidinedithiocarbamate (APDC) reduced the release of IL-18 but had no effect on the NLRP3 levels. pyrrolidine dithiocarbamic acid 41-76 interleukin 18 Homo sapiens 107-112 34879371-8 2021 miRNA-141-3p induced NLRP3, IL-1beta, and IL-18 production, decreased CXCR4, MMP, and MMP2 production, and suppressed cell growth and invasion. mirna-141-3p 0-12 interleukin 18 Homo sapiens 42-47 34204067-12 2021 In contrast, the NADPH oxidase inhibitor ammonium pyrrolidinedithiocarbamate (APDC) reduced the release of IL-18 but had no effect on the NLRP3 levels. pyrrolidine dithiocarbamic acid 78-82 interleukin 18 Homo sapiens 107-112 34204067-13 2021 Collectively, hydroquinone caused DNA damage seen as reduced intracellular PARP levels and induced NLRP3-independent IL-18 secretion in human RPE cells. hydroquinone 14-26 interleukin 18 Homo sapiens 117-122 34349888-2 2021 ROS induces NLRP3, a protein involved in the synthesis of interleukin (IL)-1 and IL-18; vaspin is a serine protease inhibitor that has an important role in suppressing the activation of NLRP3 inflammasome. Reactive Oxygen Species 0-3 interleukin 18 Homo sapiens 81-86 34349888-2 2021 ROS induces NLRP3, a protein involved in the synthesis of interleukin (IL)-1 and IL-18; vaspin is a serine protease inhibitor that has an important role in suppressing the activation of NLRP3 inflammasome. Serine 100-106 interleukin 18 Homo sapiens 81-86 34084773-12 2021 Finally, we observed increased IL-1beta and IL-18 levels in the dialysate of incident PD patients, showing a positive correlation with PGE2. Dinoprostone 135-139 interleukin 18 Homo sapiens 44-49 34350239-12 2021 We also found decreased DA secretion and TH expression, as well as increased NLRP3, caspase-1, ASC, IL-1alpha, and IL-18 expression in the MPP+ induced PD model. mangion-purified polysaccharide (Candida albicans) 139-143 interleukin 18 Homo sapiens 115-120 34066647-5 2021 Our results indicated that ethyl pyruvate significantly suppressed LPS and ATP-induced NLRP3 inflammasome activation, decreased active caspase-1 level, secretion of IL-1beta and IL-18 cytokines, and reduced the level of pyroptotic cell death resulting from inflammasome activation. ethyl pyruvate 27-41 interleukin 18 Homo sapiens 178-183 34066647-5 2021 Our results indicated that ethyl pyruvate significantly suppressed LPS and ATP-induced NLRP3 inflammasome activation, decreased active caspase-1 level, secretion of IL-1beta and IL-18 cytokines, and reduced the level of pyroptotic cell death resulting from inflammasome activation. Adenosine Triphosphate 75-78 interleukin 18 Homo sapiens 178-183 34993951-11 2022 GBA activity and GlcChol correlated with TEWL and levels of multiple cytokines, especially IL1alpha and IL-18. glcchol 17-24 interleukin 18 Homo sapiens 104-109 35346830-8 2022 The overexpression of miR-1656 can induce increased expression of pyroptosis-related genes including NLRP3, Caspase-1, IL-18, and IL-1beta by inhibiting the release of GPX4. mir-1656 22-30 interleukin 18 Homo sapiens 119-124 35346830-9 2022 This study showed that miR-1656 could increase the release of ROS by targeting GPX4, activated the NLRP3 inflammasome, and release the inflammatory factors IL-1beta and IL-18 to trigger pyroptosis in the kidney tissue of Se-deficient broilers. ros 62-65 interleukin 18 Homo sapiens 169-174 35297523-9 2022 In BPDE combined with 4-PBA intervention group, the rate of PI-positive cells was reduced, the expression levels of GRP78, GSDMD-N, and cleaved-caspase 1 were decreased, and the expression levels of IL-1beta, IL-18, and NLRP3 were decreased. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 3-7 interleukin 18 Homo sapiens 209-214 35439536-3 2022 The results showed that BPA increased the mRNA levels of IL-18, ASC, GSDMD and protein levels of NLRP3, caspase-1 and GSDMD in both cell lines in a nonlinear manner. bisphenol A 24-27 interleukin 18 Homo sapiens 57-62 35219165-10 2022 Furthermore, PR-957 treatment or CD4+ T cell depletion in chronic liver injury alleviated liver fibrosis and reduced inflammation, as indicated by the downregulation of inflammatory response markers (F4/80, IL-1, IL-6 and IL-18). PR-957 13-19 interleukin 18 Homo sapiens 222-227 34997266-14 2022 PQQ inhibits ROS generation and NF-kappaB activation, which stimulates activation of the NLRP3 inflammasome and regulates the expression of caspase-1, IL-1beta, and IL-18. PQQ Cofactor 0-3 interleukin 18 Homo sapiens 165-170 34997266-14 2022 PQQ inhibits ROS generation and NF-kappaB activation, which stimulates activation of the NLRP3 inflammasome and regulates the expression of caspase-1, IL-1beta, and IL-18. ros 13-16 interleukin 18 Homo sapiens 165-170 35584771-10 2022 GW9508 can attenuate inflammation by reducing the expression of NLRP3, ASC, caspase-1, IL-1beta, and IL-18 under HG. GW9508 0-6 interleukin 18 Homo sapiens 101-106 35385822-8 2022 Moreover, the expression of Caspase-1, NLRP3, GSDMA, IL-18, and IL-1beta and caused membrane perforation, suggesting the development of pyroptosis by chTERT in LMH cells. chtert 150-156 interleukin 18 Homo sapiens 53-58 35331853-7 2022 Puerarin ameliorated LPS-induced cytotoxicity and apoptosis, while repressing LPS-stimulated NLRP3 inflammasome-mediated pyroptosis in GES-1 cells, as evidenced by significantly decreased expression of NLRP3, ASC, cleaved caspase-1, IL-1beta and IL-18. puerarin 0-8 interleukin 18 Homo sapiens 246-251 35577580-4 2022 The aim of the study was to assess the effect of rivaroxaban (Riv) and dabigatran (Dab) on the mRNA expression of anti-inflammatory cytokines TGF-beta, IL-37, IL-35 as well as of pro-inflammatory cytokines IL-18 and IL-23, in endothelial cells damaged by 25-OHC. Rivaroxaban 49-60 interleukin 18 Homo sapiens 206-211 35577580-4 2022 The aim of the study was to assess the effect of rivaroxaban (Riv) and dabigatran (Dab) on the mRNA expression of anti-inflammatory cytokines TGF-beta, IL-37, IL-35 as well as of pro-inflammatory cytokines IL-18 and IL-23, in endothelial cells damaged by 25-OHC. Dabigatran 71-81 interleukin 18 Homo sapiens 206-211 35577580-4 2022 The aim of the study was to assess the effect of rivaroxaban (Riv) and dabigatran (Dab) on the mRNA expression of anti-inflammatory cytokines TGF-beta, IL-37, IL-35 as well as of pro-inflammatory cytokines IL-18 and IL-23, in endothelial cells damaged by 25-OHC. Dabigatran 83-86 interleukin 18 Homo sapiens 206-211 35521772-10 2022 The concentrations of follicular IL-6, IL-8 and mature IL-18 were significantly higher in PCOS group and were positively correlated with the levels of fatty acids. Fatty Acids 151-162 interleukin 18 Homo sapiens 55-60 35577580-7 2022 The results showed that 25-OHC decreased TGF-beta and IL-37 mRNA expression and increased EBI3, p35, IL-18, IL-23 mRNA expression in endothelial cell as compared to an untreated control (p<0.05). 25-hydroxycholesterol 24-30 interleukin 18 Homo sapiens 101-106 35577580-9 2022 In HUVECs pre-treated with oxysterol, rivaroxaban and dabigatran increased mRNA expression of TGF-beta, IL-37 and decreased mRNA expression of EBI3, p35, IL-23 and IL-18 as compared to 25-OHC(p<0.01). Oxysterols 27-36 interleukin 18 Homo sapiens 164-169 35577580-9 2022 In HUVECs pre-treated with oxysterol, rivaroxaban and dabigatran increased mRNA expression of TGF-beta, IL-37 and decreased mRNA expression of EBI3, p35, IL-23 and IL-18 as compared to 25-OHC(p<0.01). Rivaroxaban 38-49 interleukin 18 Homo sapiens 164-169 35577580-9 2022 In HUVECs pre-treated with oxysterol, rivaroxaban and dabigatran increased mRNA expression of TGF-beta, IL-37 and decreased mRNA expression of EBI3, p35, IL-23 and IL-18 as compared to 25-OHC(p<0.01). Dabigatran 54-64 interleukin 18 Homo sapiens 164-169 35532103-0 2022 "In silico identification of ethoxy phthalimide pyrazole derivatives as IL-17A and IL-18 targeted gouty arthritis agents". ethoxy phthalimide pyrazole 29-56 interleukin 18 Homo sapiens 83-88 35532103-2 2022 In present study, we have combined molecular docking, molecular dynamics studies and MM-PBSA analysis to study the effectiveness of ethoxy phthalimide pyrazole derivatives (series 3a to 3e) as potential inhibitors against cytokines IL17A and IL18 as a druggable targets. ethoxy phthalimide 132-150 interleukin 18 Homo sapiens 242-246 35521772-12 2022 Furthermore, oleic acid treatment induced ROS production and inflammasome activation, which is manifested by enhanced caspase-1 activity and mature IL-18 protein level. Oleic Acid 13-23 interleukin 18 Homo sapiens 148-153 35521772-12 2022 Furthermore, oleic acid treatment induced ROS production and inflammasome activation, which is manifested by enhanced caspase-1 activity and mature IL-18 protein level. ros 42-45 interleukin 18 Homo sapiens 148-153 35482664-12 2022 The baseline (week 0) TE score correlated with RF levels before, during and after DAA therapy, while plasma IL-18 levels correlated with RF level after DAA therapy. daa 152-155 interleukin 18 Homo sapiens 108-113 35334282-5 2022 Patients with vitamin D deficiency show worse renal function reflected by postoperative glomerular filtration rate (GFR) and more release of proinflammatory cytokine IL-1beta and IL-18. Vitamin D 14-23 interleukin 18 Homo sapiens 179-184 35398099-6 2022 Furthermore, our structure captured a fortuitous higher-order assembly between IL-18 and IL-18BP coordinated by a disulfide-bond distal to the binding surface connecting IL-18 and IL-18BP molecules from different complexes, resulting in a novel tetramer with 2:2 stoichiometry. Disulfides 114-123 interleukin 18 Homo sapiens 79-84 35398099-6 2022 Furthermore, our structure captured a fortuitous higher-order assembly between IL-18 and IL-18BP coordinated by a disulfide-bond distal to the binding surface connecting IL-18 and IL-18BP molecules from different complexes, resulting in a novel tetramer with 2:2 stoichiometry. Disulfides 114-123 interleukin 18 Homo sapiens 170-175 35398099-7 2022 This tetrapartite assembly was found to restrain IL-18 activity more effectively than the canonical 1:1 complex. tetrapartite 5-17 interleukin 18 Homo sapiens 49-54 35515001-7 2022 In conclusion, our results confirm that homotaurine treatment exerts an overall anti-inflammatory action in MCI patients, based not only on the down-regulation of pro-inflammatory IL-18, but also on up-regulation of the anti-inflammatory IL-33 and IL-10 cytokines, which in turn are associated with an amelioration of patient"s cognitive functions. tramiprosate 40-51 interleukin 18 Homo sapiens 180-185 35448938-6 2022 In our results, the three SCFAs could inhibit ROS expressions, NLRP3, Caspase-1, IL-1beta, IL-6, IL-18, Beclin-1 and LC3-II, when induced by 5-FU. Fluorouracil 141-145 interleukin 18 Homo sapiens 97-102 35456908-11 2022 Moreover, resveratrol reduced the levels of TNF-alpha and IL-18 that are target genes strictly downstream of the WNT/beta-catenin pathway. Resveratrol 10-21 interleukin 18 Homo sapiens 58-63 35219847-8 2022 Whereas, the NADPH oxidase (NOX) inhibitor VAS2870 had effectively inhibited the ROS level and suppressed the expression of NLRP3, ASC, Pro-Caspase-1, Cleaved-Caspase-1, N-GSDMD, IL-18, Cleaved-IL-1beta, ANP, BNP and beta-MHC. 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine 43-50 interleukin 18 Homo sapiens 179-184 35059736-12 2022 Furthermore, nicotine exposure increased the expression levels of caspase-1, IL-1beta, IL-18, NLRP3, apoptosis-associated speck-like protein and gasdermin D in 16HBE cells. Nicotine 13-21 interleukin 18 Homo sapiens 87-92 35127774-7 2021 Levels of acute phase reactant SAA and IL-6 decreased significantly after treatment with GC and leflunomide, while levels of IL-8, IL-18, and CHI3L1 did not change significantly during the follow-up period. Leflunomide 96-107 interleukin 18 Homo sapiens 131-136 35111001-4 2021 In addition, elamipretide has been shown to attenuate neural oxidative stress (hydrogen peroxide, lipid peroxidation, and ROS), neuroinflammation (TNF, IL-6, COX-2, iNOS, NLRP3, cleaved caspase-1, IL-1beta, and IL-18), and toxic protein accumulation (Abeta). arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide 13-25 interleukin 18 Homo sapiens 211-216 34964706-4 2022 Mirtazapine prevented isoflurane-induced production of the pro-inflammatory factors interleukin (IL)-1beta and IL-18 by inhibiting the activation of the nod-like receptor family protein 3 (NLRP3) inflammasome in BV2 microglia. Mirtazapine 0-11 interleukin 18 Homo sapiens 111-116 34964706-4 2022 Mirtazapine prevented isoflurane-induced production of the pro-inflammatory factors interleukin (IL)-1beta and IL-18 by inhibiting the activation of the nod-like receptor family protein 3 (NLRP3) inflammasome in BV2 microglia. Isoflurane 22-32 interleukin 18 Homo sapiens 111-116 35237974-5 2022 Importantly, activation of the nucleotide oligomerization domain leucine-rich repeat and pyrin domain containing protein 3 (NLRP3) inflammasome activates the caspase-1 protease and results in the generation and release of potent pro-inflammatory cytokines, IL-1beta and IL-18. Leucine 65-72 interleukin 18 Homo sapiens 270-275 35515001-3 2022 Inflammation plays a critical role in the pathogenesis of AD and we previously suggested that homotaurine supplementation in patients with amnestic mild cognitive impairment (MCI) plays beneficial effects associated to a decrease in the circulating levels of the pro-inflammatory cytokine IL-18. tramiprosate 94-105 interleukin 18 Homo sapiens 289-294 35515001-4 2022 Here we report that MCI patients supplemented with homotaurine for 12 months show elevated serum levels of IL-10 and IL-33, as compared to baseline, in addition to the described IL-18 decrease. tramiprosate 51-62 interleukin 18 Homo sapiens 178-183 35462936-7 2022 Furthermore, the secretion of inflammatory cytokines (IL-1beta, IL-18, IL-6, and TNF-alpha) activation of NLRP3 inflammasome and NF-kappaB signaling pathway were markedly suppressed by EC in vitro and in vivo. Catechin 185-187 interleukin 18 Homo sapiens 64-69 35401506-0 2022 GMP-Compliant Manufacturing of TRUCKs: CAR T Cells targeting GD2 and Releasing Inducible IL-18. guanosine 5'-monophosphorothioate 0-3 interleukin 18 Homo sapiens 89-94 35370605-0 2022 Mediation Effects of IL-1beta and IL-18 on the Association Between Vitamin D Levels and Mild Cognitive Impairment Among Chinese Older Adults: A Case-Control Study in Taiyuan, China. Vitamin D 67-76 interleukin 18 Homo sapiens 34-39 35023144-9 2022 After HSP70 stimulation, the expression of ROS, NLRP3, Caspase-1, and interleukin-18 (IL-18) increased significantly and could be reduced by ROS inhibitor NAC. ros 141-144 interleukin 18 Homo sapiens 70-84 35023144-9 2022 After HSP70 stimulation, the expression of ROS, NLRP3, Caspase-1, and interleukin-18 (IL-18) increased significantly and could be reduced by ROS inhibitor NAC. ros 141-144 interleukin 18 Homo sapiens 86-91 35023144-9 2022 After HSP70 stimulation, the expression of ROS, NLRP3, Caspase-1, and interleukin-18 (IL-18) increased significantly and could be reduced by ROS inhibitor NAC. Acetylcysteine 155-158 interleukin 18 Homo sapiens 70-84 35023144-9 2022 After HSP70 stimulation, the expression of ROS, NLRP3, Caspase-1, and interleukin-18 (IL-18) increased significantly and could be reduced by ROS inhibitor NAC. Acetylcysteine 155-158 interleukin 18 Homo sapiens 86-91 35023144-11 2022 In beagle models that received TmLRP, HSP70, NLRP3, Caspase-1, IL-1beta, and IL-18 were highly expressed in the wound tissue or urine, and could also be reduced by NAC pretreatment. Acetylcysteine 164-167 interleukin 18 Homo sapiens 77-82 35269384-5 2022 Apoptosis and fibrosis rates were increased under pressure, and these phenomena were aggravated following KLF2 knockdown, but were alleviated after simvastatin treatment; additionally, these changes were observed in angiotensin II, angiotensin type-1 receptor (AT1R) mRNA, and interleukin-18 (IL-18), but not in angiotensin type-2 receptor mRNA. Simvastatin 148-159 interleukin 18 Homo sapiens 277-291 35269384-5 2022 Apoptosis and fibrosis rates were increased under pressure, and these phenomena were aggravated following KLF2 knockdown, but were alleviated after simvastatin treatment; additionally, these changes were observed in angiotensin II, angiotensin type-1 receptor (AT1R) mRNA, and interleukin-18 (IL-18), but not in angiotensin type-2 receptor mRNA. Simvastatin 148-159 interleukin 18 Homo sapiens 293-298 35187677-11 2022 alpha-Mangostin treatment also inhibited the LPS-induced increase in expression levels of NLRP3, ASC and pro-caspase-1, as well as the production of IL-1beta and IL-18 in NPCs. mangostin 0-15 interleukin 18 Homo sapiens 162-167 35209305-0 2022 Simultaneous and ultra-sensitive SERS detection of SLPI and IL-18 for the assessment of donor kidney quality using black phosphorus/gold nanohybrids. sers 33-37 interleukin 18 Homo sapiens 60-65 35209305-0 2022 Simultaneous and ultra-sensitive SERS detection of SLPI and IL-18 for the assessment of donor kidney quality using black phosphorus/gold nanohybrids. Phosphorus 121-131 interleukin 18 Homo sapiens 60-65 35209305-14 2022 Giving that the combined assessment of SLPI and IL-18 expression level serves as an indicator of donor kidney quality and can be rapidly and reproducibly conducted, this SERS-based method holds great prospective in clinical practice. sers 170-174 interleukin 18 Homo sapiens 48-53