PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
8034042-1	1994	Rae-30, one of the retinoic acid (RA)-inducible cDNA clones in mouse embryonal carcinoma F9 cells, was sequenced and the deduced RAE-30 protein showed about a 70% homology to mammalian fructose 1,6-bisphosphatase (EC 3.1.3.11) (FBPase), in comparison to over 85% homology observed among the previously documented rat liver, pig kidney and human leukemic HL-60 cell FBPases.	Tretinoin	34-36	fructose bisphosphatase 2	Mus musculus	129-135
7499445-3	1995	The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2), synthesizing and degrading Fru-2,6-P2, was characterized.	fru-2,6-p2	122-132	fructose bisphosphatase 2	Mus musculus	84-92
7499445-5	1995	The dependence of PFK-2 activity on the substrate concentrations is hyperbolic (Km for Fru-6-P = 0.09 mM; Km for ATP = 0.7 mM), while the dependence of the FBPase-2 activity on the concentrations of Fru-2,6-P2 is sigmoidal (K0.5 for Fru-2,6-P2 = 4 microM).	fru-2,6-p2	199-209	fructose bisphosphatase 2	Mus musculus	156-164
7499445-5	1995	The dependence of PFK-2 activity on the substrate concentrations is hyperbolic (Km for Fru-6-P = 0.09 mM; Km for ATP = 0.7 mM), while the dependence of the FBPase-2 activity on the concentrations of Fru-2,6-P2 is sigmoidal (K0.5 for Fru-2,6-P2 = 4 microM).	fru-2,6-p2	233-243	fructose bisphosphatase 2	Mus musculus	156-164
8034042-1	1994	Rae-30, one of the retinoic acid (RA)-inducible cDNA clones in mouse embryonal carcinoma F9 cells, was sequenced and the deduced RAE-30 protein showed about a 70% homology to mammalian fructose 1,6-bisphosphatase (EC 3.1.3.11) (FBPase), in comparison to over 85% homology observed among the previously documented rat liver, pig kidney and human leukemic HL-60 cell FBPases.	Tretinoin	19-32	fructose bisphosphatase 2	Mus musculus	0-6
8034042-1	1994	Rae-30, one of the retinoic acid (RA)-inducible cDNA clones in mouse embryonal carcinoma F9 cells, was sequenced and the deduced RAE-30 protein showed about a 70% homology to mammalian fructose 1,6-bisphosphatase (EC 3.1.3.11) (FBPase), in comparison to over 85% homology observed among the previously documented rat liver, pig kidney and human leukemic HL-60 cell FBPases.	Tretinoin	34-36	fructose bisphosphatase 2	Mus musculus	0-6
33548781-9	2021	In conclusion, SiNPs triggered acute cytotoxicity and uterine inflammation by inducing glucose depletion and pyruvate overload in trophoblasts, which were mediated in part by Pfkl and Fbp2 via the pentose phosphate pathway.	Pentosephosphates	197-214	fructose bisphosphatase 2	Mus musculus	184-188
8307991-7	1994	The large increase in FBP2 expression in the F2-MTXrA line correlates with a 10-fold increase in [3H]folic acid membrane surface binding and a 1000-fold decrease in the folic acid growth requirement compared with parental L1210 cells.	Tritium	98-100	fructose bisphosphatase 2	Mus musculus	22-26
8307991-7	1994	The large increase in FBP2 expression in the F2-MTXrA line correlates with a 10-fold increase in [3H]folic acid membrane surface binding and a 1000-fold decrease in the folic acid growth requirement compared with parental L1210 cells.	Folic Acid	101-111	fructose bisphosphatase 2	Mus musculus	22-26
8307991-7	1994	The large increase in FBP2 expression in the F2-MTXrA line correlates with a 10-fold increase in [3H]folic acid membrane surface binding and a 1000-fold decrease in the folic acid growth requirement compared with parental L1210 cells.	Folic Acid	169-179	fructose bisphosphatase 2	Mus musculus	22-26
8304978-3	1994	Based on the results of northern analysis and the mobilities of affinity-labeled proteins on polyacrylamide gels, these cell lines exhibit specific up-regulated expression of FBP1 or FBP2.	polyacrylamide	93-107	fructose bisphosphatase 2	Mus musculus	183-187
30522793-5	2019	Meanwhile, altered DNA methylation patterns were exhibited in the pancreas and many differentially methylated regions (DMRs)-related genes were involved in glycolipids metabolism and related signaling pathways, including Agap2, Plcbr, Hnf1b, Gnas, Fbp2, Cdh13, Wnt2, Kcnq1, Lhcgr, Irx3, etc.	Glycolipids	156-167	fructose bisphosphatase 2	Mus musculus	248-252
33977939-3	2021	In this study, we performed integrated bioinformatic analysis and identified that fructose-1,6 biphosphatase 2 (FBP2) was involved in free fatty acids (FFAs)-induced lipid droplet accumulation in hepatocytes and HFD-induced obesity in mice.	Fatty Acids, Nonesterified	134-150	fructose bisphosphatase 2	Mus musculus	82-110
33977939-3	2021	In this study, we performed integrated bioinformatic analysis and identified that fructose-1,6 biphosphatase 2 (FBP2) was involved in free fatty acids (FFAs)-induced lipid droplet accumulation in hepatocytes and HFD-induced obesity in mice.	Fatty Acids, Nonesterified	134-150	fructose bisphosphatase 2	Mus musculus	112-116
33977939-3	2021	In this study, we performed integrated bioinformatic analysis and identified that fructose-1,6 biphosphatase 2 (FBP2) was involved in free fatty acids (FFAs)-induced lipid droplet accumulation in hepatocytes and HFD-induced obesity in mice.	Fatty Acids, Nonesterified	152-156	fructose bisphosphatase 2	Mus musculus	82-110
33977939-3	2021	In this study, we performed integrated bioinformatic analysis and identified that fructose-1,6 biphosphatase 2 (FBP2) was involved in free fatty acids (FFAs)-induced lipid droplet accumulation in hepatocytes and HFD-induced obesity in mice.	Fatty Acids, Nonesterified	152-156	fructose bisphosphatase 2	Mus musculus	112-116
32203098-2	2020	While hepatic fructose-1,6-bisphosphatase is well known as a key enzyme for gluconeogenesis, the role of muscle fructose-1,6-bisphosphatase 2 (Fbp2) in glucose disposal and thermogenesis is unknown.	Glucose	152-159	fructose bisphosphatase 2	Mus musculus	112-141
32203098-2	2020	While hepatic fructose-1,6-bisphosphatase is well known as a key enzyme for gluconeogenesis, the role of muscle fructose-1,6-bisphosphatase 2 (Fbp2) in glucose disposal and thermogenesis is unknown.	Glucose	152-159	fructose bisphosphatase 2	Mus musculus	143-147
32203098-7	2020	Mechanistically, the cold-induced intramuscular conversion of lactate to glycogen (glyconeogenesis) is completely abolished in the KO muscle, which leads to a lack of glycogen source for thermogenesis in Fbp2 KO mice.	Lactic Acid	62-69	fructose bisphosphatase 2	Mus musculus	204-208
32203098-9	2020	Taken together, these data demonstrate that Fbp2 is essential for muscle thermogenesis by replenishing the intramuscular glycogen pool through glyconeogenesis when the exogenous glucose source is limited.	Glycogen	121-129	fructose bisphosphatase 2	Mus musculus	44-48
32203098-9	2020	Taken together, these data demonstrate that Fbp2 is essential for muscle thermogenesis by replenishing the intramuscular glycogen pool through glyconeogenesis when the exogenous glucose source is limited.	Glucose	178-185	fructose bisphosphatase 2	Mus musculus	44-48
32203098-10	2020	These data imply the physiological importance of Fbp2 in thermal homeostasis and suggest a potential novel therapy targeted to increase glycogen replenishment upon cold stress.	Glycogen	136-144	fructose bisphosphatase 2	Mus musculus	49-53
33139001-9	2021	The underlying mechanism might be explained by the dysregulation of Fbp2/Cpt1a/Pfkl/Scd1 axis, which promoted the overload of glucose and lipid through the AMPK signaling pathway.	Glucose	126-133	fructose bisphosphatase 2	Mus musculus	68-72
22532827-4	2012	In this study, we used a combination of live-cell imaging and mathematical modeling to examine the effects of inducibly-expressed PFK2/FBPase2 mutants on glucose-induced Ca(2+) pulsatility in mouse islets.	Glucose	154-161	fructose bisphosphatase 2	Mus musculus	135-142
22415873-1	2012	The activity of 6-phosphofructo-1-kinase is strictly controlled by fructose-2,6-bisphosphate, the level of which is regulated by another enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK2/FBP2).	fructose 2,6-diphosphate	67-92	fructose bisphosphatase 2	Mus musculus	204-208
22415873-4	2012	We found that the transcriptional activity of the PFK2/FBP2 gene was stimulated by insulin and inhibited by cAMP and glucocorticoid.	Cyclic AMP	108-112	fructose bisphosphatase 2	Mus musculus	55-59
18164278-8	2008	Genes specifically induced by RA at 6h with the protein synthesis inhibitor cycloheximide in F9 Wt, but not in RARgamma-/- cells, included Hoxa3, Hoxa5, Gas1, Cyp26a1, Sfrp2, Fbp2, and Emp1.	Tretinoin	30-32	fructose bisphosphatase 2	Mus musculus	175-179
18164278-8	2008	Genes specifically induced by RA at 6h with the protein synthesis inhibitor cycloheximide in F9 Wt, but not in RARgamma-/- cells, included Hoxa3, Hoxa5, Gas1, Cyp26a1, Sfrp2, Fbp2, and Emp1.	Cycloheximide	76-89	fructose bisphosphatase 2	Mus musculus	175-179