PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33590347-0	2021	Dehydroabietic acid improves nonalcoholic fatty liver disease through activating the Keap1/Nrf2-ARE signaling pathway to reduce ferroptosis.	dehydroabietic acid	0-19	kelch-like ECH-associated protein 1	Mus musculus	85-90
11959095-3	2002	We show that mouse Keap1, a Caenorhabditis elegans protein that we named CKR, and human Mayven bind 5"-p-fluorosulfonyl-benzoyl-adenosine (FSBA), a covalently modifying ATP analogue.	5'-(4-fluorosulfonylbenzoyl)adenosine	139-143	kelch-like ECH-associated protein 1	Mus musculus	19-24
11959095-3	2002	We show that mouse Keap1, a Caenorhabditis elegans protein that we named CKR, and human Mayven bind 5"-p-fluorosulfonyl-benzoyl-adenosine (FSBA), a covalently modifying ATP analogue.	Adenosine Triphosphate	169-172	kelch-like ECH-associated protein 1	Mus musculus	19-24
33590347-7	2021	In all, DA may bind with Keap1, activate Nrf2-ARE, induce its target gene expression, inhibit ROS accumulation and lipid peroxidation, and reduce HFD-induced NAFLD.	dehydroabietic acid	8-10	kelch-like ECH-associated protein 1	Mus musculus	25-30
33771639-12	2021	Furthermore, GFC inhibited p62-Keap1-NRF2 pathway in estradiol-induced endometrial hyperplasia model.	Estradiol	53-62	kelch-like ECH-associated protein 1	Mus musculus	31-36
33590347-4	2021	DA binds with Keap1 to form 3 stable hydrogen bonds at VAL512 and LEU557 and increased nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response elemen (ARE) luciferase activity.	dehydroabietic acid	0-2	kelch-like ECH-associated protein 1	Mus musculus	14-19
33590347-4	2021	DA binds with Keap1 to form 3 stable hydrogen bonds at VAL512 and LEU557 and increased nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response elemen (ARE) luciferase activity.	Hydrogen	37-45	kelch-like ECH-associated protein 1	Mus musculus	14-19
34737813-0	2021	Tea polyphenols alleviate hydrogen peroxide-induced oxidative stress damage through the Mst/Nrf2 axis and the Keap1/Nrf2/HO-1 pathway in murine RAW264.7 cells.	Polyphenols	4-15	kelch-like ECH-associated protein 1	Mus musculus	110-115
33761044-5	2021	We additionally evaluated the impact of Albicanol treatment on the Keap1/Nrf2/ARE signaling pathway, and found that it was able to decrease Keap1 expression while increasing the expression of Nrf2, thereby activating this signaling pathway, suppressing oxidative damage, and enhancing the expression of downstream target genes including SOD, GSH, GST, HO-1, and NQO1 in this murine aging model system.	albicanol	40-49	kelch-like ECH-associated protein 1	Mus musculus	67-72
33761044-5	2021	We additionally evaluated the impact of Albicanol treatment on the Keap1/Nrf2/ARE signaling pathway, and found that it was able to decrease Keap1 expression while increasing the expression of Nrf2, thereby activating this signaling pathway, suppressing oxidative damage, and enhancing the expression of downstream target genes including SOD, GSH, GST, HO-1, and NQO1 in this murine aging model system.	albicanol	40-49	kelch-like ECH-associated protein 1	Mus musculus	140-145
33591165-8	2021	These data suggested that YVLLPSPK improved learning and memory in scopolamine-induced cognitive-impaired mice through a mechanism associated with PINK1-mediated mitophagy via the NRF2/KEAP1/HO-1 pathway.	Scopolamine	67-78	kelch-like ECH-associated protein 1	Mus musculus	185-190
34896238-6	2022	Moreover, ACR exposure significantly increased levels of MDA and COX-2), decreased GSH level and antioxidant enzyme activity (SOD, GSH-PX and CAT) by downregulating expression of Nrf2 and Keap1 in diabetic mice.	Acrylamide	10-13	kelch-like ECH-associated protein 1	Mus musculus	188-193
34890768-6	2022	Mechanistically, 1,25(OH)2D3 enhances VDR-mediated recruitment of Ezh2 and facilitation of H3K27me3 action at the promoter region of Keap1, thus transcriptionally repressing Keap1.	(oh)2d3	21-28	kelch-like ECH-associated protein 1	Mus musculus	133-138
34890768-6	2022	Mechanistically, 1,25(OH)2D3 enhances VDR-mediated recruitment of Ezh2 and facilitation of H3K27me3 action at the promoter region of Keap1, thus transcriptionally repressing Keap1.	(oh)2d3	21-28	kelch-like ECH-associated protein 1	Mus musculus	174-179
33777312-5	2021	Knockdown of p22phox/keap1 or use of an NADPH oxidase inhibitor (apocynin) reversed the production of superoxide anion and inflammatory cytokines, which then reduced neuronal damage and death in vitro and in vivo.	Superoxides	102-118	kelch-like ECH-associated protein 1	Mus musculus	21-26
34737813-0	2021	Tea polyphenols alleviate hydrogen peroxide-induced oxidative stress damage through the Mst/Nrf2 axis and the Keap1/Nrf2/HO-1 pathway in murine RAW264.7 cells.	Hydrogen Peroxide	26-43	kelch-like ECH-associated protein 1	Mus musculus	110-115
34562841-10	2021	Mechanistically, MINO exerted the effects of anti-inflammation and anti-oxidative stress through down-regulating the expression of MALAT1 and regulating Nrf2/Keap1 and NF-kappaB signaling pathways.	Minocycline	17-21	kelch-like ECH-associated protein 1	Mus musculus	158-163
34271100-0	2021	Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway.	sulforaphane	29-41	kelch-like ECH-associated protein 1	Mus musculus	91-96
34829046-0	2021	Green Pea (Pisum sativum L.) Hull Polyphenol Extracts Ameliorate DSS-Induced Colitis through Keap1/Nrf2 Pathway and Gut Microbiota Modulation.	Polyphenols	34-44	kelch-like ECH-associated protein 1	Mus musculus	93-98
34526248-0	2021	A bioactive ligand-conjugated iridium(III) metal-based complex as a Keap1-Nrf2 protein-protein interaction inhibitor against acetaminophen-induced acute liver injury.	Iridium	30-42	kelch-like ECH-associated protein 1	Mus musculus	68-73
34526248-0	2021	A bioactive ligand-conjugated iridium(III) metal-based complex as a Keap1-Nrf2 protein-protein interaction inhibitor against acetaminophen-induced acute liver injury.	Metals	43-48	kelch-like ECH-associated protein 1	Mus musculus	68-73
34526248-0	2021	A bioactive ligand-conjugated iridium(III) metal-based complex as a Keap1-Nrf2 protein-protein interaction inhibitor against acetaminophen-induced acute liver injury.	Acetaminophen	125-138	kelch-like ECH-associated protein 1	Mus musculus	68-73
34526248-5	2021	The iridium (III) complex 1 bearing a bioactive ligand 2,9-dimethyl-1,10-phenanthroline and 4-chloro-2-phenylquinoline, a derivative of the bioactive ligand 2-phenylquinoline, was identified as a direct small-molecule inhibitor of the Keap1-Nrf2 protein-protein interaction.	Iridium	4-17	kelch-like ECH-associated protein 1	Mus musculus	235-240
34526248-5	2021	The iridium (III) complex 1 bearing a bioactive ligand 2,9-dimethyl-1,10-phenanthroline and 4-chloro-2-phenylquinoline, a derivative of the bioactive ligand 2-phenylquinoline, was identified as a direct small-molecule inhibitor of the Keap1-Nrf2 protein-protein interaction.	neocuproine	55-87	kelch-like ECH-associated protein 1	Mus musculus	235-240
34526248-5	2021	The iridium (III) complex 1 bearing a bioactive ligand 2,9-dimethyl-1,10-phenanthroline and 4-chloro-2-phenylquinoline, a derivative of the bioactive ligand 2-phenylquinoline, was identified as a direct small-molecule inhibitor of the Keap1-Nrf2 protein-protein interaction.	4-chloro-2-phenylquinoline	92-118	kelch-like ECH-associated protein 1	Mus musculus	235-240
34526248-5	2021	The iridium (III) complex 1 bearing a bioactive ligand 2,9-dimethyl-1,10-phenanthroline and 4-chloro-2-phenylquinoline, a derivative of the bioactive ligand 2-phenylquinoline, was identified as a direct small-molecule inhibitor of the Keap1-Nrf2 protein-protein interaction.	2-phenylquinoline	157-174	kelch-like ECH-associated protein 1	Mus musculus	235-240
34526248-7	2021	Moreover, 1 reversed APAP-induced liver damage by disrupting Keap1-Nrf2 interaction and without inducing organ damage and immunotoxicity in mice.	Acetaminophen	21-25	kelch-like ECH-associated protein 1	Mus musculus	61-66
34526248-8	2021	Our study demonstrates the identification of a selective and efficacious antagonist of Keap1-Nrf2 interaction possessed good cellular permeability in cellulo and ideal pharmacokinetic parameters in vivo, and, more importantly, validates the feasibility of conjugating metal complexes with bioactive ligands to generate metal-based drug leads as non-toxic Keap1-Nrf2 interaction inhibitors for treating APAP-induced acute liver injury.	Metals	268-273	kelch-like ECH-associated protein 1	Mus musculus	87-92
34526248-8	2021	Our study demonstrates the identification of a selective and efficacious antagonist of Keap1-Nrf2 interaction possessed good cellular permeability in cellulo and ideal pharmacokinetic parameters in vivo, and, more importantly, validates the feasibility of conjugating metal complexes with bioactive ligands to generate metal-based drug leads as non-toxic Keap1-Nrf2 interaction inhibitors for treating APAP-induced acute liver injury.	Metals	268-273	kelch-like ECH-associated protein 1	Mus musculus	355-360
34526248-8	2021	Our study demonstrates the identification of a selective and efficacious antagonist of Keap1-Nrf2 interaction possessed good cellular permeability in cellulo and ideal pharmacokinetic parameters in vivo, and, more importantly, validates the feasibility of conjugating metal complexes with bioactive ligands to generate metal-based drug leads as non-toxic Keap1-Nrf2 interaction inhibitors for treating APAP-induced acute liver injury.	Metals	319-324	kelch-like ECH-associated protein 1	Mus musculus	87-92
34526248-8	2021	Our study demonstrates the identification of a selective and efficacious antagonist of Keap1-Nrf2 interaction possessed good cellular permeability in cellulo and ideal pharmacokinetic parameters in vivo, and, more importantly, validates the feasibility of conjugating metal complexes with bioactive ligands to generate metal-based drug leads as non-toxic Keap1-Nrf2 interaction inhibitors for treating APAP-induced acute liver injury.	Metals	319-324	kelch-like ECH-associated protein 1	Mus musculus	355-360
34526248-8	2021	Our study demonstrates the identification of a selective and efficacious antagonist of Keap1-Nrf2 interaction possessed good cellular permeability in cellulo and ideal pharmacokinetic parameters in vivo, and, more importantly, validates the feasibility of conjugating metal complexes with bioactive ligands to generate metal-based drug leads as non-toxic Keap1-Nrf2 interaction inhibitors for treating APAP-induced acute liver injury.	Acetaminophen	402-406	kelch-like ECH-associated protein 1	Mus musculus	87-92
34899723-9	2021	Taken together, 4.4x106 CFU/mL CB pretreatment can alleviate ETEC K88-induced oxidative damage through activating the p62-Keap1-Nrf2 signaling pathway and remodeling the cecal microbiota community in mice.	etec k88	61-69	kelch-like ECH-associated protein 1	Mus musculus	122-127
34676557-6	2022	Copper-induced oxidative damage further decreased the phosphorylation of CREB, decreased expression of Bcl-2, enhanced expression of Bax, and accelerated the dissociation of keap1-Nrf2 complex, promoted the nuclear translocation of Nrf2, stimulate the expression of antioxidant molecules HO-1 and NQO1.	Copper	0-6	kelch-like ECH-associated protein 1	Mus musculus	174-179
34628205-3	2021	Results showed that OS-LL11 could directly scavenge free radicals and sustain the viability of mouse keratinocytes challenged by ultraviolet B (UVB) irradiation or hydrogen peroxide (H2O2) by decreasing the levels of lipid peroxidation, malondialdehyde, and reactive oxygen species while increasing the level of catalase, Keap-1, HO-1, GCLM, and NQO1.	os-ll11	20-27	kelch-like ECH-associated protein 1	Mus musculus	322-328
34628205-3	2021	Results showed that OS-LL11 could directly scavenge free radicals and sustain the viability of mouse keratinocytes challenged by ultraviolet B (UVB) irradiation or hydrogen peroxide (H2O2) by decreasing the levels of lipid peroxidation, malondialdehyde, and reactive oxygen species while increasing the level of catalase, Keap-1, HO-1, GCLM, and NQO1.	Hydrogen Peroxide	164-181	kelch-like ECH-associated protein 1	Mus musculus	322-328
34628205-3	2021	Results showed that OS-LL11 could directly scavenge free radicals and sustain the viability of mouse keratinocytes challenged by ultraviolet B (UVB) irradiation or hydrogen peroxide (H2O2) by decreasing the levels of lipid peroxidation, malondialdehyde, and reactive oxygen species while increasing the level of catalase, Keap-1, HO-1, GCLM, and NQO1.	Hydrogen Peroxide	183-187	kelch-like ECH-associated protein 1	Mus musculus	322-328
34364124-8	2021	Additionally, melatonin promoted the nuclear translocation and expression of Nrf2 and the protein degradation of Keap1.	Melatonin	14-23	kelch-like ECH-associated protein 1	Mus musculus	113-118
34461498-7	2021	In addition, OGDR-induced myocardial cell death and apoptosis were largely ameliorated after pretreatment with the novel Keap1 inhibitor.	ogdr	13-17	kelch-like ECH-associated protein 1	Mus musculus	121-126
34454721-0	2021	Resveratrol ameliorates thoracic blast exposure-induced inflammation, endoplasmic reticulum stress and apoptosis in the brain through the Nrf2/Keap1 and NF-kappaB signaling pathway.	Resveratrol	0-11	kelch-like ECH-associated protein 1	Mus musculus	143-148
34721041-11	2021	Results: Compared with the ATO group, the HES treatment groups reduced the levels of CK, LDH, cTnI, ROS, MDA, TNF-alpha, IL-6, Bax, Caspase-3, cleaved-Caspase-3 and Keap1 and enhanced the levels of SOD, GSH, CAT, Bcl-2, p62 and Nrf2.	Hesperidin	42-45	kelch-like ECH-associated protein 1	Mus musculus	165-170
34721041-0	2021	Based on Activation of p62-Keap1-Nrf2 Pathway, Hesperidin Protects Arsenic-Trioxide-Induced Cardiotoxicity in Mice.	Hesperidin	47-57	kelch-like ECH-associated protein 1	Mus musculus	27-32
34721041-11	2021	Results: Compared with the ATO group, the HES treatment groups reduced the levels of CK, LDH, cTnI, ROS, MDA, TNF-alpha, IL-6, Bax, Caspase-3, cleaved-Caspase-3 and Keap1 and enhanced the levels of SOD, GSH, CAT, Bcl-2, p62 and Nrf2.	Arsenic Trioxide	27-30	kelch-like ECH-associated protein 1	Mus musculus	165-170
34454721-13	2021	Additionally, resveratrol significantly ameliorated thoracic blast exposure-induced increases of Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor (NF)-kappaB and the decrease in nuclear factor erythroid 2-related factor 2(Nrf2) expression in the brain (P < 0.05).	Resveratrol	14-25	kelch-like ECH-associated protein 1	Mus musculus	97-132
34087360-0	2021	Minocycline inhibits sleep deprivation-induced aberrant microglial activation and Keap1-Nrf2 expression in mouse hippocampus.	Minocycline	0-11	kelch-like ECH-associated protein 1	Mus musculus	82-87
34454721-13	2021	Additionally, resveratrol significantly ameliorated thoracic blast exposure-induced increases of Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor (NF)-kappaB and the decrease in nuclear factor erythroid 2-related factor 2(Nrf2) expression in the brain (P < 0.05).	Resveratrol	14-25	kelch-like ECH-associated protein 1	Mus musculus	134-139
34454721-14	2021	Our results indicate that resveratrol has a protective effect on thoracic blast exposure-induced brain injury that is likely mediated through the Nrf2/Keap1 and NF-kappaB signaling pathways.	Resveratrol	26-37	kelch-like ECH-associated protein 1	Mus musculus	151-156
34573125-0	2021	Lycopene Protects Intestinal Epithelium from Deoxynivalenol-Induced Oxidative Damage via Regulating Keap1/Nrf2 Signaling.	Lycopene	0-8	kelch-like ECH-associated protein 1	Mus musculus	100-105
34333354-9	2021	Subsequently, TSG promoted the activation of GSH/GPX4/ROS and Keap1/Nrf2/ARE signaling pathways.	tsg	14-17	kelch-like ECH-associated protein 1	Mus musculus	62-67
34087360-9	2021	Interestingly, treatment with the microglial modulator minocycline prevented SD-induced microglial activation, restored Keap1 and Nrf2 levels, normalized neuronal oscillations, and alleviated depressive-like and anxiety-like behavior.	Minocycline	55-66	kelch-like ECH-associated protein 1	Mus musculus	120-125
34087360-10	2021	The present study reveals that microglial activation and Keap1-Nrf2 signaling play a crucial role in SD-induced behavioral alteration, and that minocycline treatment has a protective effect on these alterations.	Minocycline	144-155	kelch-like ECH-associated protein 1	Mus musculus	57-62
34400522-9	2021	Keap1 was required for viral induction of G9a-GLP lysine methyltransferase binding and H3K9me2 modification at cytokine genes.	Lysine	50-56	kelch-like ECH-associated protein 1	Mus musculus	0-5
34391968-0	2021	Resveratrol attenuates rotenone-induced inflammation and oxidative stress via STAT1 and Nrf2/Keap1/SLC7A11 pathway in a microglia cell line.	Resveratrol	0-11	kelch-like ECH-associated protein 1	Mus musculus	93-98
34294378-0	2021	Andrographolide improves PCP-induced schizophrenia-like behaviors through blocking interaction between NRF2 and KEAP1.	andrographolide	0-15	kelch-like ECH-associated protein 1	Mus musculus	112-117
34294378-7	2021	In addition, andrographolide increased expression of NRF-2, HO-1 and NQO-1, promoted nuclear translocation of NRF-2 through blocking the interaction between NRF-2 and KEAP1, which may be associated with directly binding to NRF-2.	andrographolide	13-28	kelch-like ECH-associated protein 1	Mus musculus	167-172
34391968-0	2021	Resveratrol attenuates rotenone-induced inflammation and oxidative stress via STAT1 and Nrf2/Keap1/SLC7A11 pathway in a microglia cell line.	Rotenone	23-31	kelch-like ECH-associated protein 1	Mus musculus	93-98
34391968-12	2021	In addition, resveratrol enhanced the protective effect of on rotenone-induced BV-2 cells via the inhibition of STAT1 and Keap1 and the upregulation of Nrf2 and SLC7A11.	Resveratrol	13-24	kelch-like ECH-associated protein 1	Mus musculus	122-127
34391968-12	2021	In addition, resveratrol enhanced the protective effect of on rotenone-induced BV-2 cells via the inhibition of STAT1 and Keap1 and the upregulation of Nrf2 and SLC7A11.	Rotenone	62-70	kelch-like ECH-associated protein 1	Mus musculus	122-127
34391968-13	2021	CONCLUSION: Resveratrol attenuated rotenone-induced inflammation and oxidative stress in BV-2 cells through enhancing the inhibition of STAT1and Keap1 and the upregulation of Nrf2 and SLC7A11.	Resveratrol	12-23	kelch-like ECH-associated protein 1	Mus musculus	145-150
34391968-13	2021	CONCLUSION: Resveratrol attenuated rotenone-induced inflammation and oxidative stress in BV-2 cells through enhancing the inhibition of STAT1and Keap1 and the upregulation of Nrf2 and SLC7A11.	Rotenone	35-43	kelch-like ECH-associated protein 1	Mus musculus	145-150
34252790-0	2021	Optimization of 1,4-bis(arylsulfonamido)naphthalene-N,N"-diacetic acids as inhibitors of Keap1-Nrf2 protein-protein interaction to suppress neuroinflammation.	1,4-bis(arylsulfonamido)naphthalene-n,n"-diacetic acids	16-71	kelch-like ECH-associated protein 1	Mus musculus	89-94
34216418-6	2021	Furthermore, LC activated Nrf2 signaling by binding to Keap1 to reverse the striking DON-induced increase in ROS levels.	deoxynivalenol	85-88	kelch-like ECH-associated protein 1	Mus musculus	55-60
34216418-6	2021	Furthermore, LC activated Nrf2 signaling by binding to Keap1 to reverse the striking DON-induced increase in ROS levels.	ros	109-112	kelch-like ECH-associated protein 1	Mus musculus	55-60
34484559-12	2021	Mechanically, the keap1/Nrf2/HO-1 signaling pathway was also investigated in order to unveil its molecular mechanism, and the results showed that MG-Exos could increase the protein levels of Nrf2 and HO-1 via inhibiting the keap1; they also triggered the expression of its downstream antioxidative-related genes, such as NQo1, Gclc, Cat, and Gsx1.	Magnesium	146-148	kelch-like ECH-associated protein 1	Mus musculus	18-23
34484559-12	2021	Mechanically, the keap1/Nrf2/HO-1 signaling pathway was also investigated in order to unveil its molecular mechanism, and the results showed that MG-Exos could increase the protein levels of Nrf2 and HO-1 via inhibiting the keap1; they also triggered the expression of its downstream antioxidative-related genes, such as NQo1, Gclc, Cat, and Gsx1.	Magnesium	146-148	kelch-like ECH-associated protein 1	Mus musculus	224-229
34484559-13	2021	Our findings indicated that MG-Exos exerted an antioxidant effect and positively modulated vascular regeneration and neurological functional recovery post-SCI by activating keap1/Nrf2/HO-1 signaling.	Magnesium	28-30	kelch-like ECH-associated protein 1	Mus musculus	173-178
34421890-9	2021	Additionally, the activation of mitochondrial uncoupling protein 2 and phospho-Nuclear Factor-kappa B p65 and the inhibition of the kelch-like ECH-associated protein 1 and NF-E2-related factor 2 induced by DSS were also reversed under JUG administration.	Dextran Sulfate	206-209	kelch-like ECH-associated protein 1	Mus musculus	132-167
34426758-0	2021	Mitoquinone Protects Podocytes from Angiotensin II-Induced Mitochondrial Dysfunction and Injury via the Keap1-Nrf2 Signaling Pathway.	mitoquinone	0-11	kelch-like ECH-associated protein 1	Mus musculus	104-109
34426758-9	2021	Moreover, MitoQ rescued the expression and translocation of Nrf2 (nuclear factor E2-related factor 2) and decreased the expression of Keap1 (Kelch-like ECH-associated protein 1) in Ang II-stimulated podocytes.	mitoquinone	10-15	kelch-like ECH-associated protein 1	Mus musculus	134-139
34426758-9	2021	Moreover, MitoQ rescued the expression and translocation of Nrf2 (nuclear factor E2-related factor 2) and decreased the expression of Keap1 (Kelch-like ECH-associated protein 1) in Ang II-stimulated podocytes.	mitoquinone	10-15	kelch-like ECH-associated protein 1	Mus musculus	141-176
34426758-11	2021	These results demonstrate that MitoQ exerts a protective effect in Ang II-induced mitochondrial injury in podocytes via the Keap1-Nrf2 signaling pathway.	mitoquinone	31-36	kelch-like ECH-associated protein 1	Mus musculus	124-129
34471563-6	2021	Moreover, anwulignan increased the production of Nrf2, HO-1 and NQO1 proteins and decreased the production level of Keap1 protein in the renal tissue in the d-galactose induced aging mice.	macelignan	10-20	kelch-like ECH-associated protein 1	Mus musculus	116-121
34155807-7	2021	Treatment with PB2 reduced oxidative stress by activating Nrf-2/Keap1, AMPK/GSK3beta signalling pathways and autophagy.	procyanidin B2	15-18	kelch-like ECH-associated protein 1	Mus musculus	64-69
34229586-8	2021	Furthermore, overexpression of miR-141-3p ameliorated the cytotoxic effects of H2O2 on NP cells, which were abrogated by upregulating Keap1 and silencing Nrf2.	mir-141-3p	31-41	kelch-like ECH-associated protein 1	Mus musculus	134-139
34229586-8	2021	Furthermore, overexpression of miR-141-3p ameliorated the cytotoxic effects of H2O2 on NP cells, which were abrogated by upregulating Keap1 and silencing Nrf2.	Hydrogen Peroxide	79-83	kelch-like ECH-associated protein 1	Mus musculus	134-139
34200377-11	2021	Arteries from Aldo-infused mice also exhibited decreased nuclear Nrf2 and increased Keap1 expression.	Aldosterone	14-18	kelch-like ECH-associated protein 1	Mus musculus	84-89
34143548-8	2021	Furthermore, GYY4137 activated the Nrf2/ARE pathway through the sulfhydrylation of Keap1 and inhibited oxidative stress.	GYY 4137	13-20	kelch-like ECH-associated protein 1	Mus musculus	83-88
34143548-10	2021	In conclusion, this study indicated that through the sulfhydrylation of Keap1, GYY4137 activated the Nrf2/ARE pathway and exerted anti-inflammatory, anti-apoptotic and antioxidant effects in septic mice that consequently protected the integrity of the BBB and improved the clinical outcome of sepsis.	GYY 4137	79-86	kelch-like ECH-associated protein 1	Mus musculus	72-77
34298930-6	2021	(3) Results: Lsel-/-Keap1Deltahepa mice exhibited increased expression of erythroid 2-related factor 2 (Nrf2) target genes in the liver, decreased body weight, reduced epidydimal white adipose tissue with decreased immune cell frequencies, and improved glucose response when compared to their Lsel-/-Keap1flx/flx littermates.	Glucose	253-260	kelch-like ECH-associated protein 1	Mus musculus	20-34
34226516-0	2021	A novel Keap1 inhibitor iKeap1 activates Nrf2 signaling and ameliorates hydrogen peroxide-induced oxidative injury and apoptosis in osteoblasts.	Hydrogen Peroxide	72-89	kelch-like ECH-associated protein 1	Mus musculus	8-13
34200377-12	2021	Our findings suggest that Aldo reduces vascular Nrf2 transcriptional activity by Keap1-dependent mechanisms, contributing to mineralocorticoid-induced vascular dysfunction.	Aldosterone	26-30	kelch-like ECH-associated protein 1	Mus musculus	81-86
34149419-5	2021	Furthermore, RANKL-mediated signaling pathways including MAPK, NF-kappaB and calcium ossification were hampered, whereas ROS scavenging enzymes in Nrf2/Keap1/ARE signaling pathways were promoted by NOT.	Reactive Oxygen Species	121-124	kelch-like ECH-associated protein 1	Mus musculus	152-157
34074127-2	2021	The expression of HO-1 is triggered by the Nrf2-Keap1 signaling pathway which responds to exogenous stress signals and dietary constituents such as flavonoids and glucosinolates or reactive metabolic intermediates like 4-hydroxynonenal.	Flavonoids	148-158	kelch-like ECH-associated protein 1	Mus musculus	48-53
34199606-0	2021	Sanghuangporus sanghuang Mycelium Prevents Paracetamol-Induced Hepatotoxicity through Regulating the MAPK/NF-kappaB, Keap1/Nrf2/HO-1, TLR4/PI3K/Akt, and CaMKKbeta/LKB1/AMPK Pathways and Suppressing Oxidative Stress and Inflammation.	Acetaminophen	43-54	kelch-like ECH-associated protein 1	Mus musculus	117-122
34074127-2	2021	The expression of HO-1 is triggered by the Nrf2-Keap1 signaling pathway which responds to exogenous stress signals and dietary constituents such as flavonoids and glucosinolates or reactive metabolic intermediates like 4-hydroxynonenal.	Glucosinolates	163-177	kelch-like ECH-associated protein 1	Mus musculus	48-53
34074127-2	2021	The expression of HO-1 is triggered by the Nrf2-Keap1 signaling pathway which responds to exogenous stress signals and dietary constituents such as flavonoids and glucosinolates or reactive metabolic intermediates like 4-hydroxynonenal.	4-hydroxy-2-nonenal	219-235	kelch-like ECH-associated protein 1	Mus musculus	48-53
35588739-5	2022	Sensing by Cysteine 151 of the NRF2 chaperone, Kelch-like ECH-associated protein 1 (KEAP1) was required for NSAID activation of NRF2 and subsequent anti-inflammatory effects both in vitro and in vivo.	Cysteine	11-19	kelch-like ECH-associated protein 1	Mus musculus	47-82
35605295-8	2022	In the MI cell model, low concentrations of DEX attenuated the H2O2-induced decreases in cell viability and antioxidative enzyme levels and activated the Keap1/Nrf2/HO-1 pathway.	Dexamethasone	44-47	kelch-like ECH-associated protein 1	Mus musculus	154-159
35605295-8	2022	In the MI cell model, low concentrations of DEX attenuated the H2O2-induced decreases in cell viability and antioxidative enzyme levels and activated the Keap1/Nrf2/HO-1 pathway.	Hydrogen Peroxide	63-67	kelch-like ECH-associated protein 1	Mus musculus	154-159
35605295-10	2022	The protective effects of DEX on myocardial tissues were mediated by the Keap1/Nrf2/HO-1 pathway.	Dexamethasone	26-29	kelch-like ECH-associated protein 1	Mus musculus	73-78
34203049-7	2021	Furthermore, IHC and western blot results suggested antioxidant (Keap-1/Nrf-2/HO-1), anti-inflammatory (TLR-4/NF-kB) and anti-apoptotic (Bcl-2/Bax/Caspase-3) effect of Bergenin.	bergenin	168-176	kelch-like ECH-associated protein 1	Mus musculus	65-71
35605295-6	2022	DEX (50 mug/kg/day) administration also significantly decreased the production of reactive oxygen species (ROS) and pro-inflammatory cytokines, increased the expression of antioxidative enzymes, and activated the Keap1/Nrf2/HO-1 pathway.	Dexamethasone	0-3	kelch-like ECH-associated protein 1	Mus musculus	213-218
35537248-0	2022	Hydnocarpin D attenuates lipopolysaccharide-induced acute lung injury via MAPK/NF-kappaB and Keap1/Nrf2/HO-1 pathway.	Hydnocarpin D	0-13	kelch-like ECH-associated protein 1	Mus musculus	93-98
35588739-5	2022	Sensing by Cysteine 151 of the NRF2 chaperone, Kelch-like ECH-associated protein 1 (KEAP1) was required for NSAID activation of NRF2 and subsequent anti-inflammatory effects both in vitro and in vivo.	Cysteine	11-19	kelch-like ECH-associated protein 1	Mus musculus	84-89
35355074-0	2022	Combination of monoammonium glycyrrhizinate and cysteine hydrochloride protects mice against acetaminophen-induced liver injury via Keap1/Nrf2/ARE pathway.	AMMONIUM GLYCYRRHIZINATE	15-43	kelch-like ECH-associated protein 1	Mus musculus	132-137
35355074-0	2022	Combination of monoammonium glycyrrhizinate and cysteine hydrochloride protects mice against acetaminophen-induced liver injury via Keap1/Nrf2/ARE pathway.	Cysteine	48-70	kelch-like ECH-associated protein 1	Mus musculus	132-137
35355074-0	2022	Combination of monoammonium glycyrrhizinate and cysteine hydrochloride protects mice against acetaminophen-induced liver injury via Keap1/Nrf2/ARE pathway.	Acetaminophen	93-106	kelch-like ECH-associated protein 1	Mus musculus	132-137
35355074-12	2022	CONCLUSION: The study demonstrated that MG-CH had protective effects against DILI induced by APAP and the potential mechanisms were based on inhibiting oxidative stress and activating the Keap1/Nrf2/ARE pathway.	Acetaminophen	93-97	kelch-like ECH-associated protein 1	Mus musculus	188-193
35227644-6	2022	We also showed that metformin treatment increased the ubiquitination and proteasomal degradation of NRF2 through a KEAP1-independent mechanism.	Metformin	20-29	kelch-like ECH-associated protein 1	Mus musculus	115-120
35580647-10	2022	It was shown by molecular docking that the new derivatives are incorporated into the binding site of the protein Keap1 Kelch-domain by their pyrimidine substituent with the formation of more non-covalent bonds.	pyrimidine	141-151	kelch-like ECH-associated protein 1	Mus musculus	113-118
35585885-0	2022	Orcinol Glucoside Improves Senile Osteoporosis through Attenuating Oxidative Stress and Autophagy of Osteoclast via Activating Nrf2/Keap1 and mTOR Signaling Pathway.	Orcinol glucoside	0-17	kelch-like ECH-associated protein 1	Mus musculus	132-137
35585885-8	2022	Of note, the effect of OG on Nrf2/Keap1 signaling was neutralized by the mTOR inhibitor rapamycin.	octyl-beta-D-glucoside	23-25	kelch-like ECH-associated protein 1	Mus musculus	34-39
35585885-8	2022	Of note, the effect of OG on Nrf2/Keap1 signaling was neutralized by the mTOR inhibitor rapamycin.	Sirolimus	88-97	kelch-like ECH-associated protein 1	Mus musculus	34-39
35319828-6	2022	Mechanistically, regulation of the ROS/NO balance activated the antioxidant defense system and protected against oxidative stress induced by I/R injury via adaptive regulation of the Nrf2-Keap1 pathway.	Reactive Oxygen Species	35-38	kelch-like ECH-associated protein 1	Mus musculus	188-193
35368107-0	2022	Collagen peptides from Acaudina molpadioides prevent CCl4 -induced liver injury via Keap1/Nrf2-ARE, PI3K/AKT, and MAPKs pathways.	Carbon Tetrachloride	53-57	kelch-like ECH-associated protein 1	Mus musculus	84-89
35259495-0	2022	DL-3-n-butylphthalide prevents oxidative stress and atherosclerosis by targeting Keap-1 and inhibiting Keap-1/Nrf-2 interaction.	3-n-butylphthalide	0-21	kelch-like ECH-associated protein 1	Mus musculus	81-87
35259495-0	2022	DL-3-n-butylphthalide prevents oxidative stress and atherosclerosis by targeting Keap-1 and inhibiting Keap-1/Nrf-2 interaction.	3-n-butylphthalide	0-21	kelch-like ECH-associated protein 1	Mus musculus	103-109
35368107-4	2022	Western blot results disclosed that AMP (200 mg/kg) upregulated the Nrf2 level by 73.8% and downregulated Keap1 by 41.0% in CCl4 -induced mice liver.	Adenosine Monophosphate	36-39	kelch-like ECH-associated protein 1	Mus musculus	106-111
35368107-4	2022	Western blot results disclosed that AMP (200 mg/kg) upregulated the Nrf2 level by 73.8% and downregulated Keap1 by 41.0% in CCl4 -induced mice liver.	Carbon Tetrachloride	124-128	kelch-like ECH-associated protein 1	Mus musculus	106-111
35368107-6	2022	Furthermore, the trends of Nrf2, Keap1, p-ERK, p-JNK, p-p38, p-PI3K, and p-AKT levels in H2 O2 -induced RAW264.7 cells after AMP treatment were similar to the results in CCl4 -induced mice liver.	Hydrogen Peroxide	89-94	kelch-like ECH-associated protein 1	Mus musculus	33-38
35368107-7	2022	These findings provided evidence that AMP exerted antioxidant activity via Keap1/Nrf2-ARE, PI3K/AKT, and MAPKs pathways in vivo and in vitro.	Adenosine Monophosphate	38-41	kelch-like ECH-associated protein 1	Mus musculus	75-80
35332348-0	2022	Hesperidin protects against cisplatin-induced cardiotoxicity in mice by regulating the p62-Keap1-Nrf2 pathway.	Hesperidin	0-10	kelch-like ECH-associated protein 1	Mus musculus	91-96
35369899-2	2022	TPNA10168, which was identified from a chemical library as a potential activator of the Keap1-Nrf2-ARE pathway, exhibits a neuroprotective effect against oxidative stress-induced injury.	tpna10168	0-9	kelch-like ECH-associated protein 1	Mus musculus	88-93
35412826-4	2022	Also, RP treatment could activate the Kelch-like ECH-associating protein 1 (Keap1)-nuclear factor E2-related factor 2 (Nrf2) signaling pathway, mediate the expression of downstream antioxidant protease (NQO-1, HO-1, and Gclc), regulate gut microbiota by enhancing the relative abundance of Akkermansia and increasing the value of F/B, and adjust short-chain fatty acid levels to alleviate DSS-induced colitis in mice.	Fatty Acids	358-368	kelch-like ECH-associated protein 1	Mus musculus	76-81
35412826-4	2022	Also, RP treatment could activate the Kelch-like ECH-associating protein 1 (Keap1)-nuclear factor E2-related factor 2 (Nrf2) signaling pathway, mediate the expression of downstream antioxidant protease (NQO-1, HO-1, and Gclc), regulate gut microbiota by enhancing the relative abundance of Akkermansia and increasing the value of F/B, and adjust short-chain fatty acid levels to alleviate DSS-induced colitis in mice.	Dextran Sulfate	389-392	kelch-like ECH-associated protein 1	Mus musculus	76-81
35462905-11	2022	BCD treatment also promoted nuclear translocation rates of Bach 1 and Nrf2, suppressed Keap 1 protein expression, as well as raised HO-1 protein expression.	bcd	0-3	kelch-like ECH-associated protein 1	Mus musculus	87-93
35395160-0	2022	p-Chloro-diphenyl diselenide modulates Nrf2/Keap1 signaling and counteracts renal oxidative stress in mice exposed to dexamethasone repeated administrations.	p-chloro-diphenyl diselenide	0-28	kelch-like ECH-associated protein 1	Mus musculus	44-49
35395160-0	2022	p-Chloro-diphenyl diselenide modulates Nrf2/Keap1 signaling and counteracts renal oxidative stress in mice exposed to dexamethasone repeated administrations.	Dexamethasone	118-131	kelch-like ECH-associated protein 1	Mus musculus	44-49
35395160-9	2022	At 5 mg/kg, (p-ClPhSe)2 reduced the renal levels of 4-OH-2-HNE and HO-1 as well as modulated the Nrf2/Keap-1 signaling in mice exposed to dexamethasone.	p-chloro-diphenyl diselenide	12-22	kelch-like ECH-associated protein 1	Mus musculus	102-108
35395160-10	2022	The present findings revealed that (p-ClPhSe)2 antioxidant effects were associated with the modulation of Nrf2/Keap-1 signaling pathway in the kidney of mice exposed to dexamethasone.	(p-clphse)2	35-46	kelch-like ECH-associated protein 1	Mus musculus	111-117
35395160-10	2022	The present findings revealed that (p-ClPhSe)2 antioxidant effects were associated with the modulation of Nrf2/Keap-1 signaling pathway in the kidney of mice exposed to dexamethasone.	Dexamethasone	169-182	kelch-like ECH-associated protein 1	Mus musculus	111-117
35388754-0	2022	Keap1 as Target of Genistein on Nrf2 Signaling Pathway Antagonizing Abeta induced Oxidative Damage of Cerebrovascular Endothelial Cells.	Genistein	19-28	kelch-like ECH-associated protein 1	Mus musculus	0-5
35332348-0	2022	Hesperidin protects against cisplatin-induced cardiotoxicity in mice by regulating the p62-Keap1-Nrf2 pathway.	Cisplatin	28-37	kelch-like ECH-associated protein 1	Mus musculus	91-96
35332348-12	2022	HES treatment also improved the expression of pathway proteins p62 and Nrf2 and inhibited the increase in CP-induced Keap1 expression.	Hesperidin	0-3	kelch-like ECH-associated protein 1	Mus musculus	117-122
35332348-13	2022	Thus, HES may provide protection against CP cardiotoxicity through inhibiting oxidative stress, inflammation, and apoptosis, which may contribute to activation of the p62-Keap1-Nrf2 signalling pathway.	Hesperidin	6-9	kelch-like ECH-associated protein 1	Mus musculus	171-176
35124564-0	2022	Ginsenoside Rd attenuates cerebral ischemia/reperfusion injury by exerting an anti-pyroptotic effect via the miR-139-5p/FoxO1/Keap1/Nrf2 axis.	Ginsenosides	0-11	kelch-like ECH-associated protein 1	Mus musculus	126-131
35041848-7	2022	Interestingly, both pretreatment and posttreatment with SFN significantly improved the abnormal behaviors of mice in the MWMT, in parallel with the up-regulated levels of Keap1-Nrf2 signaling in the mPFC, hippocampus and liver.	sulforaphane	56-59	kelch-like ECH-associated protein 1	Mus musculus	171-176
35124564-6	2022	More importantly, Rd upregulated miR-139-5p to inhibit FoxO1 which regulates Keap1 transcriptional activity, and subsequently activates the Nrf2 antioxidant pathway, resulting in attenuation of ROS/TXNIP/NLRP3 inflammasome axis-driven pyroptosis in these animal and cell models.	mir-139-5p	33-43	kelch-like ECH-associated protein 1	Mus musculus	77-82
35124564-7	2022	In summary, an anti-pyroptotic effect via the miR-139-5p/FoxO1/Keap1/Nrf2 axis may be the mechanism by which Rd attenuates ischemic stroke.	mir-139-	46-54	kelch-like ECH-associated protein 1	Mus musculus	63-68
35124564-6	2022	More importantly, Rd upregulated miR-139-5p to inhibit FoxO1 which regulates Keap1 transcriptional activity, and subsequently activates the Nrf2 antioxidant pathway, resulting in attenuation of ROS/TXNIP/NLRP3 inflammasome axis-driven pyroptosis in these animal and cell models.	Reactive Oxygen Species	194-197	kelch-like ECH-associated protein 1	Mus musculus	77-82
35531720-0	2022	(Mechanism of Tibetan medicine Ershiwuwei Songshi Pills against liver injury induced by acetaminophen in mice based on Keap1/Nrf2 and TLR4/NF-kappaB p65 signaling pathways).	Acetaminophen	88-101	kelch-like ECH-associated protein 1	Mus musculus	119-124
35531720-10	2022	ESP can reduce the oxidative damage and inflammation caused by APAP, and the mechanism may be related to the Keap1/Nrf2 signaling pathway and the signal transduction factors on the TLR4/NF-kappaB p65 pathway.	Acetaminophen	63-67	kelch-like ECH-associated protein 1	Mus musculus	109-114
35531724-0	2022	(Mechanism of Tibetan medicine Ershiwuwei Shanhu Pills on scopolamine-induced learning and memory impairment in mice based on Keap1/Nrf2/HO-1 signaling pathway).	Scopolamine	58-69	kelch-like ECH-associated protein 1	Mus musculus	126-131
35531724-1	2022	This study aims to investigate the mechanism of the Tibetan medicine Ershiwuwei Shanhu Pills(ESP) in improving scopolamine-induced learning and memory impairment in mice based on Keap1/Nrf2/HO-1 signaling pathway.	Scopolamine	111-122	kelch-like ECH-associated protein 1	Mus musculus	179-184
35401244-0	2022	Isorhamnetin Alleviates Airway Inflammation by Regulating the Nrf2/Keap1 Pathway in a Mouse Model of COPD.	3-methylquercetin	0-12	kelch-like ECH-associated protein 1	Mus musculus	67-72
35531724-15	2022	In conclusion, ESP protected mice against the scopolamine-induced learning and memory impairment by regulating the Keap1/Nrf2/HO-1 signaling pathway.	Scopolamine	46-57	kelch-like ECH-associated protein 1	Mus musculus	115-120
35387263-0	2022	Icariside II Attenuates Methamphetamine-Induced Neurotoxicity and Behavioral Impairments via Activating the Keap1-Nrf2 Pathway.	baohuoside I	0-12	kelch-like ECH-associated protein 1	Mus musculus	108-113
35387263-0	2022	Icariside II Attenuates Methamphetamine-Induced Neurotoxicity and Behavioral Impairments via Activating the Keap1-Nrf2 Pathway.	Methamphetamine	24-39	kelch-like ECH-associated protein 1	Mus musculus	108-113
35387263-7	2022	Our data also indicated that when ICS combated METH-induced neurotoxicity, it was accompanied by partial correction of the abnormal Kelch 2 like ECH2 associated protein 1 (Keap1)-nuclear factor erythroid-2-related factor 2 (Nrf2) pathway and oxidative stress response.	Methamphetamine	47-51	kelch-like ECH-associated protein 1	Mus musculus	132-170
35387263-7	2022	Our data also indicated that when ICS combated METH-induced neurotoxicity, it was accompanied by partial correction of the abnormal Kelch 2 like ECH2 associated protein 1 (Keap1)-nuclear factor erythroid-2-related factor 2 (Nrf2) pathway and oxidative stress response.	Methamphetamine	47-51	kelch-like ECH-associated protein 1	Mus musculus	172-177
35401244-8	2022	Mechanistically, Iso may degrade Keap1 through ubiquitination of p62, thereby activating the nuclear factor erythroid 2-related factor (Nrf2) pathway to increase the expression of protective factors, such as heme oxygenase-1 (HO-1), superoxide dismutase (SOD) 1, and SOD2, in lungs of CS-exposed mice, which plays an anti-inflammatory role in COPD.	3-methylquercetin	17-20	kelch-like ECH-associated protein 1	Mus musculus	33-38
35325199-0	2022	Hyperoside, a natural flavonoid compound, attenuates Triptolide-induced testicular damage by activating the Keap1-Nrf2 and SIRT1-PGC1alpha signalling pathway.	hyperoside	0-10	kelch-like ECH-associated protein 1	Mus musculus	108-113
35401244-8	2022	Mechanistically, Iso may degrade Keap1 through ubiquitination of p62, thereby activating the nuclear factor erythroid 2-related factor (Nrf2) pathway to increase the expression of protective factors, such as heme oxygenase-1 (HO-1), superoxide dismutase (SOD) 1, and SOD2, in lungs of CS-exposed mice, which plays an anti-inflammatory role in COPD.	Cesium	285-287	kelch-like ECH-associated protein 1	Mus musculus	33-38
35401244-9	2022	In conclusion, our study indicates that Iso significantly alleviates the inflammatory response in CS-induced COPD mice mainly by affecting the Nrf2/Keap1 pathway.	3-methylquercetin	40-43	kelch-like ECH-associated protein 1	Mus musculus	148-153
35401244-9	2022	In conclusion, our study indicates that Iso significantly alleviates the inflammatory response in CS-induced COPD mice mainly by affecting the Nrf2/Keap1 pathway.	Cesium	98-100	kelch-like ECH-associated protein 1	Mus musculus	148-153
35342347-6	2022	Subsequently, molecular docking and dynamics simulation study revealed a binding mode between UA and Nrf-2/Keap1 including the hydrogen-bonding network among oxygen atoms in UA with the Nrf-2/Keap1 residues Arg 415, Ser 508 and Ser 602, which in turn trigger Nrf2 nuclear translocation, subsequently leading to activation of Nrf-2 target genes (HO-1, NQO1).	Hydrogen	127-135	kelch-like ECH-associated protein 1	Mus musculus	107-112
35321327-0	2022	Dehydrocostus Lactone Suppresses Dextran Sulfate Sodium-Induced Colitis by Targeting the IKKalpha/beta-NF-kappaB and Keap1-Nrf2 Signalling Pathways.	Lactones	14-21	kelch-like ECH-associated protein 1	Mus musculus	117-122
35321327-0	2022	Dehydrocostus Lactone Suppresses Dextran Sulfate Sodium-Induced Colitis by Targeting the IKKalpha/beta-NF-kappaB and Keap1-Nrf2 Signalling Pathways.	Dextran Sulfate	33-55	kelch-like ECH-associated protein 1	Mus musculus	117-122
35321327-7	2022	Furthermore, DCL-mediated actions were abolished by dithiothreitol, suggesting a thiol-mediated covalent linkage between DCL and IKKalpha/beta or Keap1.	dehydrocostus lactone	13-16	kelch-like ECH-associated protein 1	Mus musculus	146-151
35321327-7	2022	Furthermore, DCL-mediated actions were abolished by dithiothreitol, suggesting a thiol-mediated covalent linkage between DCL and IKKalpha/beta or Keap1.	Dithiothreitol	52-66	kelch-like ECH-associated protein 1	Mus musculus	146-151
35321327-7	2022	Furthermore, DCL-mediated actions were abolished by dithiothreitol, suggesting a thiol-mediated covalent linkage between DCL and IKKalpha/beta or Keap1.	Sulfhydryl Compounds	81-86	kelch-like ECH-associated protein 1	Mus musculus	146-151
35149217-7	2022	Whereas, the combined use of two ROS-specific inhibitors and adopted with melatonin markedly rescued PM2.5-triggered macrophage M1 polarization and foam cell formation by inhibiting NOX2-mediated crosstalk of Keap1/Nrf2/NF-kappaB and TLR4/TRAF6/NF-kappaB signaling pathways.	ros	33-36	kelch-like ECH-associated protein 1	Mus musculus	209-214
35149217-7	2022	Whereas, the combined use of two ROS-specific inhibitors and adopted with melatonin markedly rescued PM2.5-triggered macrophage M1 polarization and foam cell formation by inhibiting NOX2-mediated crosstalk of Keap1/Nrf2/NF-kappaB and TLR4/TRAF6/NF-kappaB signaling pathways.	Melatonin	74-83	kelch-like ECH-associated protein 1	Mus musculus	209-214
35030388-0	2022	Perillyl alcohol attenuates rheumatoid arthritis via regulating TLR4/NF-kappaB and Keap1/Nrf2 signaling pathways: A comprehensive study onin-vitro and in-vivo experimental models.	perillyl alcohol	0-16	kelch-like ECH-associated protein 1	Mus musculus	83-88
35342347-6	2022	Subsequently, molecular docking and dynamics simulation study revealed a binding mode between UA and Nrf-2/Keap1 including the hydrogen-bonding network among oxygen atoms in UA with the Nrf-2/Keap1 residues Arg 415, Ser 508 and Ser 602, which in turn trigger Nrf2 nuclear translocation, subsequently leading to activation of Nrf-2 target genes (HO-1, NQO1).	Serine	228-231	kelch-like ECH-associated protein 1	Mus musculus	107-112
35342347-6	2022	Subsequently, molecular docking and dynamics simulation study revealed a binding mode between UA and Nrf-2/Keap1 including the hydrogen-bonding network among oxygen atoms in UA with the Nrf-2/Keap1 residues Arg 415, Ser 508 and Ser 602, which in turn trigger Nrf2 nuclear translocation, subsequently leading to activation of Nrf-2 target genes (HO-1, NQO1).	Serine	228-231	kelch-like ECH-associated protein 1	Mus musculus	192-197
35342347-6	2022	Subsequently, molecular docking and dynamics simulation study revealed a binding mode between UA and Nrf-2/Keap1 including the hydrogen-bonding network among oxygen atoms in UA with the Nrf-2/Keap1 residues Arg 415, Ser 508 and Ser 602, which in turn trigger Nrf2 nuclear translocation, subsequently leading to activation of Nrf-2 target genes (HO-1, NQO1).	Hydrogen	127-135	kelch-like ECH-associated protein 1	Mus musculus	192-197
35342347-6	2022	Subsequently, molecular docking and dynamics simulation study revealed a binding mode between UA and Nrf-2/Keap1 including the hydrogen-bonding network among oxygen atoms in UA with the Nrf-2/Keap1 residues Arg 415, Ser 508 and Ser 602, which in turn trigger Nrf2 nuclear translocation, subsequently leading to activation of Nrf-2 target genes (HO-1, NQO1).	Oxygen	158-164	kelch-like ECH-associated protein 1	Mus musculus	107-112
35342347-6	2022	Subsequently, molecular docking and dynamics simulation study revealed a binding mode between UA and Nrf-2/Keap1 including the hydrogen-bonding network among oxygen atoms in UA with the Nrf-2/Keap1 residues Arg 415, Ser 508 and Ser 602, which in turn trigger Nrf2 nuclear translocation, subsequently leading to activation of Nrf-2 target genes (HO-1, NQO1).	Oxygen	158-164	kelch-like ECH-associated protein 1	Mus musculus	192-197
35342347-6	2022	Subsequently, molecular docking and dynamics simulation study revealed a binding mode between UA and Nrf-2/Keap1 including the hydrogen-bonding network among oxygen atoms in UA with the Nrf-2/Keap1 residues Arg 415, Ser 508 and Ser 602, which in turn trigger Nrf2 nuclear translocation, subsequently leading to activation of Nrf-2 target genes (HO-1, NQO1).	Arginine	207-210	kelch-like ECH-associated protein 1	Mus musculus	107-112
35342347-6	2022	Subsequently, molecular docking and dynamics simulation study revealed a binding mode between UA and Nrf-2/Keap1 including the hydrogen-bonding network among oxygen atoms in UA with the Nrf-2/Keap1 residues Arg 415, Ser 508 and Ser 602, which in turn trigger Nrf2 nuclear translocation, subsequently leading to activation of Nrf-2 target genes (HO-1, NQO1).	Arginine	207-210	kelch-like ECH-associated protein 1	Mus musculus	192-197
35342347-6	2022	Subsequently, molecular docking and dynamics simulation study revealed a binding mode between UA and Nrf-2/Keap1 including the hydrogen-bonding network among oxygen atoms in UA with the Nrf-2/Keap1 residues Arg 415, Ser 508 and Ser 602, which in turn trigger Nrf2 nuclear translocation, subsequently leading to activation of Nrf-2 target genes (HO-1, NQO1).	Serine	216-219	kelch-like ECH-associated protein 1	Mus musculus	107-112
35342347-6	2022	Subsequently, molecular docking and dynamics simulation study revealed a binding mode between UA and Nrf-2/Keap1 including the hydrogen-bonding network among oxygen atoms in UA with the Nrf-2/Keap1 residues Arg 415, Ser 508 and Ser 602, which in turn trigger Nrf2 nuclear translocation, subsequently leading to activation of Nrf-2 target genes (HO-1, NQO1).	Serine	216-219	kelch-like ECH-associated protein 1	Mus musculus	192-197
35284456-7	2022	Additionally, GTPs abrogated dysregulation in hepatic Kelch-like ECH-associated protein 1 and nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream target gene expression (heme oxygenase 1, NAD(P)H:quinone oxidoreductase 1, and GST) and inhibited tumor necrosis factor-alpha, transforming growth factor-beta, and interleukin (IL)-1beta and IL-6 in the liver of treated mice.	gtps	14-18	kelch-like ECH-associated protein 1	Mus musculus	54-89
34999086-0	2022	Isoorientin protects lipopolysaccharide-induced acute lung injury in mice via modulating Keap1/Nrf2-HO-1 and NLRP3 inflammasome pathways.	homoorientin	0-11	kelch-like ECH-associated protein 1	Mus musculus	89-94
35118857-3	2022	Additionally, EPS103 protected against oxidative stress by activating antioxidation enzymes and Nrf2/Keap1 pathways.	eps103	14-20	kelch-like ECH-associated protein 1	Mus musculus	101-106
35074488-13	2022	Consistent with the in vitro results, DHT significantly delayed tumor growth in HO8910PM and ES2 xenograft nude mice, decreased tumor marker HE4 and CA125 levels, reversed the abnormally expressed proteins including Ki67, Nrf2, p62, Keap1, Bcl-2, CyclinB1, Cdc-2, and antioxidant enzymes SOD, CAT in vivo.	Dihydrotestosterone	38-41	kelch-like ECH-associated protein 1	Mus musculus	233-238
35206076-7	2022	The Western blot (WB) results indicated that the STP supplement effectively altered the expression of oxidative stress-related protein by modulating the NRF2/KEAP1 pathway.	stp	49-52	kelch-like ECH-associated protein 1	Mus musculus	158-163
34999086-8	2022	Additionally, ISO significantly promoted the expression of nuclear factor E2-related factor 2 (Nrf2), heme oxygenase 1 (HO-1) and down-regulated kelch-like ECH-associated protein 1 (Keap1).	homoorientin	14-17	kelch-like ECH-associated protein 1	Mus musculus	145-180
34999086-8	2022	Additionally, ISO significantly promoted the expression of nuclear factor E2-related factor 2 (Nrf2), heme oxygenase 1 (HO-1) and down-regulated kelch-like ECH-associated protein 1 (Keap1).	homoorientin	14-17	kelch-like ECH-associated protein 1	Mus musculus	182-187
34999086-10	2022	Meanwhile, the results of molecular docking indicated the potential ability of ISO as a ligand binding with proteins Keap1, NLRP3 and cleaved-caspase-3 as well.	homoorientin	79-82	kelch-like ECH-associated protein 1	Mus musculus	117-122
35204232-0	2022	Dietary Selenium Alleviated Mouse Liver Oxidative Stress and NAFLD Induced by Obesity by Regulating the KEAP1/NRF2 Pathway.	Selenium	8-16	kelch-like ECH-associated protein 1	Mus musculus	104-109
35204232-7	2022	In addition, selenium can promote selenoproteinP1 (SEPP1) synthesis to regulate the Kelch-like ECH-associated protein 1 (KEAP1)/NF-E2-related factor 2 (NRF2) pathway, so as to defend against hepatocyte oxidative stress.	Selenium	13-21	kelch-like ECH-associated protein 1	Mus musculus	84-119
35204232-7	2022	In addition, selenium can promote selenoproteinP1 (SEPP1) synthesis to regulate the Kelch-like ECH-associated protein 1 (KEAP1)/NF-E2-related factor 2 (NRF2) pathway, so as to defend against hepatocyte oxidative stress.	Selenium	13-21	kelch-like ECH-associated protein 1	Mus musculus	121-126
35204232-8	2022	These findings suggest that dietary selenium supplementation can effectively resist hepatic injury and insulin resistance during NAFLD development, and regulate the KEAP1/NRF2 pathway to resist oxidative stress by promoting SEPP1 synthesis.	Selenium	36-44	kelch-like ECH-associated protein 1	Mus musculus	165-170
35040204-0	2022	Urolithin A alleviates acute kidney injury induced by renal ischemia reperfusion through the p62-Keap1-Nrf2 signaling pathway.	3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one	0-11	kelch-like ECH-associated protein 1	Mus musculus	97-102
35185586-13	2022	The oxidation-related Keap1-Nrf2 pathway, SODs enzyme, the cell cycle control-related CDC25C-CDK1 pathway, and the steroidogenic-related pathway may contribute to this protective effects of TCE.	Trichloroethylene	190-193	kelch-like ECH-associated protein 1	Mus musculus	22-27
35040204-4	2022	The expression levels of p62 and Keap1 significantly decreased, while that of nuclear Nrf2 increased in vitro in a hypoxia cell model after UA treatment.	3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one	140-142	kelch-like ECH-associated protein 1	Mus musculus	33-38
35040204-6	2022	In this study, we demonstrated that UA can alleviate oxidative stress and promote autophagy by activating the p62-Keap1-Nrf2 signaling pathway, which could protect the kidneys from ischemia reperfusion injury.	3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one	36-38	kelch-like ECH-associated protein 1	Mus musculus	114-119
35204061-7	2022	Furthermore, PAE inhibited the activities of Keap1 and promoted Nrf2 transfer from cytoplasm to nucleus, which were mediated by excessive accumulation of ROS in the VVC mice.	Reactive Oxygen Species	154-157	kelch-like ECH-associated protein 1	Mus musculus	45-50
33949241-8	2021	Moreover, the downregulated Kelch-like ECH-associated protein-1 (Keap1), upregulated nuclear factor erythroid 2-related factor 2 (Nrf2) and its translocation activation after NAM administration were confirmed, which were in accordance with improved superoxide dismutase (SOD) and glutathione (GSH) levels.	Niacinamide	175-178	kelch-like ECH-associated protein 1	Mus musculus	28-63
35046823-0	2021	Proanthocyanidins Protect Against Cadmium-Induced Diabetic Nephropathy Through p38 MAPK and Keap1/Nrf2 Signaling Pathways.	Proanthocyanidins	0-17	kelch-like ECH-associated protein 1	Mus musculus	92-97
33857757-0	2021	Skeletal muscle-specific Keap1 disruption modulates fatty acid utilization and enhances exercise capacity in female mice.	Fatty Acids	52-62	kelch-like ECH-associated protein 1	Mus musculus	25-30
34058234-0	2021	Protective effect of alpha-lipoic acid on bisphenol A-induced learning and memory impairment in developing mice: nNOS and keap1/Nrf2 pathway.	Thioctic Acid	21-38	kelch-like ECH-associated protein 1	Mus musculus	122-127
34058234-8	2021	ALA altered the protein levels of nNOS and keap1/Nrf2 pathway affected by BPA.	Thioctic Acid	0-3	kelch-like ECH-associated protein 1	Mus musculus	43-48
34058234-8	2021	ALA altered the protein levels of nNOS and keap1/Nrf2 pathway affected by BPA.	bisphenol A	74-77	kelch-like ECH-associated protein 1	Mus musculus	43-48
34058234-9	2021	Our results suggested that impairments of learning and memory caused by BPA was related to the damage of hippocampal synapses mediated by oxidative stress, and ALA protected learning and memory by reducing the oxidative stress induced by BPA through regulating the nNOS and keap1/Nrf2 pathway.	Thioctic Acid	160-163	kelch-like ECH-associated protein 1	Mus musculus	274-279
34058234-9	2021	Our results suggested that impairments of learning and memory caused by BPA was related to the damage of hippocampal synapses mediated by oxidative stress, and ALA protected learning and memory by reducing the oxidative stress induced by BPA through regulating the nNOS and keap1/Nrf2 pathway.	bisphenol A	238-241	kelch-like ECH-associated protein 1	Mus musculus	274-279
33949241-8	2021	Moreover, the downregulated Kelch-like ECH-associated protein-1 (Keap1), upregulated nuclear factor erythroid 2-related factor 2 (Nrf2) and its translocation activation after NAM administration were confirmed, which were in accordance with improved superoxide dismutase (SOD) and glutathione (GSH) levels.	Niacinamide	175-178	kelch-like ECH-associated protein 1	Mus musculus	65-70
33482216-5	2021	The results showed LCC-A possesses higher in vitro ROS-scavenging ability than LCC-B (89.8% vs 57.8%) and to inhibit osteoclast differentiation, whereas LCC-B more significantly activates cellular antioxidant activities via the KEAP1-NRF2-ARE pathway (218.5% vs 438.0% in the level of HO-1), thus promoting osteoblast differentiation in an inflammatory environment.	lcc-a	19-24	kelch-like ECH-associated protein 1	Mus musculus	228-233
33734387-0	2021	Chlorogenic acid ameliorates mice clinical endometritis by activating Keap1/Nrf2 and inhibiting NFkappaB signalling pathway.	Chlorogenic Acid	0-16	kelch-like ECH-associated protein 1	Mus musculus	70-75
33891667-8	2021	Klotho treatment restored palmitate-induced downregulation of the antioxidant molecules, Nrf2, Keap1, and SOD1.	Palmitates	26-35	kelch-like ECH-associated protein 1	Mus musculus	95-100
33482216-5	2021	The results showed LCC-A possesses higher in vitro ROS-scavenging ability than LCC-B (89.8% vs 57.8%) and to inhibit osteoclast differentiation, whereas LCC-B more significantly activates cellular antioxidant activities via the KEAP1-NRF2-ARE pathway (218.5% vs 438.0% in the level of HO-1), thus promoting osteoblast differentiation in an inflammatory environment.	lcc-b	153-158	kelch-like ECH-associated protein 1	Mus musculus	228-233
33924467-14	2021	Overall, kurarinone showed an anti-inflammatory effect by inhibiting Th1 and Th17 cell differentiation and an antioxidant effect exerted in part through activating the Nrf-2/KEAP-1 pathway.	kurarinone	9-19	kelch-like ECH-associated protein 1	Mus musculus	174-180
33359640-0	2021	Butyrate alleviates PTZ-induced mitochondrial dysfunction, oxidative stress and neuron apoptosis in mice via Keap1/Nrf2/HO-1 pathway.	Pentylenetetrazole	20-23	kelch-like ECH-associated protein 1	Mus musculus	109-114
33757524-0	2021	Correction to: A combination of herbal compound (SPTC) along with exercise or metformin more efficiently alleviated diabetic complications through down-regulation of stress oxidative pathway upon activating Nrf2-Keap1 axis in AGE rich diet-induced type 2 diabetic mice.	Metformin	78-87	kelch-like ECH-associated protein 1	Mus musculus	212-217
33724516-0	2021	Steatotic hepatocytes release mature VLDL via methionine and tyrosine metabolism in a Keap1-Nrf2 dependent manner.	Methionine	46-56	kelch-like ECH-associated protein 1	Mus musculus	86-91
33724516-0	2021	Steatotic hepatocytes release mature VLDL via methionine and tyrosine metabolism in a Keap1-Nrf2 dependent manner.	Tyrosine	61-69	kelch-like ECH-associated protein 1	Mus musculus	86-91
33724516-8	2021	Mice fed a HF, Met restricted and Tyr deficient diet showed the NAFLD-like phenotype in which the nuclear translocation of Nrf2, triglyceride-rich VLDL and fumarate were decreased in liver but Keap1 hepa ameliorated these phenomena.	Tyrosine	34-37	kelch-like ECH-associated protein 1	Mus musculus	193-198
33724516-9	2021	Reactive oxygen species and LDs induced by the deprivation of Met and Tyr were prevented in hepatic organoids generated from Keap1 hepa .	Oxygen	9-15	kelch-like ECH-associated protein 1	Mus musculus	125-130
33724516-9	2021	Reactive oxygen species and LDs induced by the deprivation of Met and Tyr were prevented in hepatic organoids generated from Keap1 hepa .	Tyrosine	70-73	kelch-like ECH-associated protein 1	Mus musculus	125-130
33395605-0	2021	Sinomenine protects bone from destruction to ameliorate arthritis via activating p62Thr269/Ser272-Keap1-Nrf2 feedback loop.	sinomenine	0-10	kelch-like ECH-associated protein 1	Mus musculus	98-103
33359640-0	2021	Butyrate alleviates PTZ-induced mitochondrial dysfunction, oxidative stress and neuron apoptosis in mice via Keap1/Nrf2/HO-1 pathway.	Butyrates	0-8	kelch-like ECH-associated protein 1	Mus musculus	109-114
33607539-4	2021	Data firstly showed that Cd-inhibited Nrf2 pathway was markedly restored by PU treatment, assessed by Nrf2 nuclear translocation, protein levels of Keap1 and Nrf2 downstream target genes.	Cadmium	25-27	kelch-like ECH-associated protein 1	Mus musculus	148-153
33607539-4	2021	Data firstly showed that Cd-inhibited Nrf2 pathway was markedly restored by PU treatment, assessed by Nrf2 nuclear translocation, protein levels of Keap1 and Nrf2 downstream target genes.	puerarin	76-78	kelch-like ECH-associated protein 1	Mus musculus	148-153
33653364-0	2021	Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2/HO-1 pathway.	panaxydol	0-9	kelch-like ECH-associated protein 1	Mus musculus	82-87
33359640-6	2021	The activation of Keap1/Nrf2/HO-1 signals was also identified, in which the antiepileptic effect of SB may be partially due to its anti-mitochondrial injury and neuroprotective activities.	Butyric Acid	100-102	kelch-like ECH-associated protein 1	Mus musculus	18-23
33118665-9	2021	In conclusion, irigenin alleviated MPP+ -induced neurotoxicity in BV-2 cells through regulating the Keap1/Nrf2 pathway.	irigenin	15-23	kelch-like ECH-associated protein 1	Mus musculus	100-105
33368846-0	2021	Tiron alleviates MPTP-induced Parkinsonism in mice via activation of Keap-1/Nrf2 pathway.	1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt	0-5	kelch-like ECH-associated protein 1	Mus musculus	69-75
33368846-0	2021	Tiron alleviates MPTP-induced Parkinsonism in mice via activation of Keap-1/Nrf2 pathway.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	17-21	kelch-like ECH-associated protein 1	Mus musculus	69-75
33342543-8	2021	In mice, microarray analysis revealed that Keap1 deletion induces NRF2 target genes involved in glutathione metabolism and xenobiotic stress (e.g., Nqo1).	Glutathione	96-107	kelch-like ECH-associated protein 1	Mus musculus	43-48
33342543-9	2021	Furthermore, deficiency of one of the most important antioxidants, glutathione (GSH), in NEMODeltahepa livers was rescued after deleting Keap1.	Glutathione	67-78	kelch-like ECH-associated protein 1	Mus musculus	137-142
33342543-9	2021	Furthermore, deficiency of one of the most important antioxidants, glutathione (GSH), in NEMODeltahepa livers was rescued after deleting Keap1.	Glutathione	80-83	kelch-like ECH-associated protein 1	Mus musculus	137-142
33118665-0	2021	Protective effects of irigenin against 1-methyl-4-phenylpyridinium-induced neurotoxicity through regulating the Keap1/Nrf2 pathway.	irigenin	22-30	kelch-like ECH-associated protein 1	Mus musculus	112-117
33118665-0	2021	Protective effects of irigenin against 1-methyl-4-phenylpyridinium-induced neurotoxicity through regulating the Keap1/Nrf2 pathway.	1-Methyl-4-phenylpyridinium	39-66	kelch-like ECH-associated protein 1	Mus musculus	112-117
33118665-7	2021	Interestingly, irigenin activated the Keap1/Nrf2 pathway in MPP+ -induced BV-2 cells.	irigenin	15-23	kelch-like ECH-associated protein 1	Mus musculus	38-43
33118665-7	2021	Interestingly, irigenin activated the Keap1/Nrf2 pathway in MPP+ -induced BV-2 cells.	mangion-purified polysaccharide (Candida albicans)	60-64	kelch-like ECH-associated protein 1	Mus musculus	38-43
33118665-9	2021	In conclusion, irigenin alleviated MPP+ -induced neurotoxicity in BV-2 cells through regulating the Keap1/Nrf2 pathway.	mangion-purified polysaccharide (Candida albicans)	35-39	kelch-like ECH-associated protein 1	Mus musculus	100-105
33603948-4	2021	Bixin was found to activate Nrf2 signals by the modification of critical Keap1 (Kelch-like ECH-associated protein 1) cystine and competitive interaction with Keap1 with upregulating P62 mRNA and protein expression.	bixin	0-5	kelch-like ECH-associated protein 1	Mus musculus	73-78
33243512-0	2021	Protective effects of rare earth lanthanum on acute ethanol-induced oxidative stress in mice via Keap 1/Nrf2/p62 activation.	Lanthanum	33-42	kelch-like ECH-associated protein 1	Mus musculus	97-103
33243512-0	2021	Protective effects of rare earth lanthanum on acute ethanol-induced oxidative stress in mice via Keap 1/Nrf2/p62 activation.	Ethanol	52-59	kelch-like ECH-associated protein 1	Mus musculus	97-103
33243512-9	2021	Our findings clearly highlighted that La(NO3)3 could restore the redox homeostasis disrupted by ethanol through provoking Keap 1/Nrf2/p62 signaling pathway, and the optimal dosages were 1.0 and 2.0 mg/kg.	la(no3)3	38-46	kelch-like ECH-associated protein 1	Mus musculus	122-128
33243512-9	2021	Our findings clearly highlighted that La(NO3)3 could restore the redox homeostasis disrupted by ethanol through provoking Keap 1/Nrf2/p62 signaling pathway, and the optimal dosages were 1.0 and 2.0 mg/kg.	Ethanol	96-103	kelch-like ECH-associated protein 1	Mus musculus	122-128
33603948-4	2021	Bixin was found to activate Nrf2 signals by the modification of critical Keap1 (Kelch-like ECH-associated protein 1) cystine and competitive interaction with Keap1 with upregulating P62 mRNA and protein expression.	bixin	0-5	kelch-like ECH-associated protein 1	Mus musculus	80-115
33603948-4	2021	Bixin was found to activate Nrf2 signals by the modification of critical Keap1 (Kelch-like ECH-associated protein 1) cystine and competitive interaction with Keap1 with upregulating P62 mRNA and protein expression.	bixin	0-5	kelch-like ECH-associated protein 1	Mus musculus	158-163
33603948-4	2021	Bixin was found to activate Nrf2 signals by the modification of critical Keap1 (Kelch-like ECH-associated protein 1) cystine and competitive interaction with Keap1 with upregulating P62 mRNA and protein expression.	Cystine	117-124	kelch-like ECH-associated protein 1	Mus musculus	73-78
33502009-7	2021	Molecular docking showed that resveratrol had hydrogen bonding interactions with Kelch-like ECH associated protein 1 (Keap1), a repressor protein of the classic antioxidant Keap1-Nrf2 pathway.	Resveratrol	30-41	kelch-like ECH-associated protein 1	Mus musculus	81-116
33502009-7	2021	Molecular docking showed that resveratrol had hydrogen bonding interactions with Kelch-like ECH associated protein 1 (Keap1), a repressor protein of the classic antioxidant Keap1-Nrf2 pathway.	Resveratrol	30-41	kelch-like ECH-associated protein 1	Mus musculus	118-123
33502009-7	2021	Molecular docking showed that resveratrol had hydrogen bonding interactions with Kelch-like ECH associated protein 1 (Keap1), a repressor protein of the classic antioxidant Keap1-Nrf2 pathway.	Resveratrol	30-41	kelch-like ECH-associated protein 1	Mus musculus	173-178
33502009-7	2021	Molecular docking showed that resveratrol had hydrogen bonding interactions with Kelch-like ECH associated protein 1 (Keap1), a repressor protein of the classic antioxidant Keap1-Nrf2 pathway.	Hydrogen	46-54	kelch-like ECH-associated protein 1	Mus musculus	81-116
33502009-7	2021	Molecular docking showed that resveratrol had hydrogen bonding interactions with Kelch-like ECH associated protein 1 (Keap1), a repressor protein of the classic antioxidant Keap1-Nrf2 pathway.	Hydrogen	46-54	kelch-like ECH-associated protein 1	Mus musculus	118-123
33502009-10	2021	Therefore, these findings suggested that the prevention of resveratrol on memory dysfunction induced by METH was possibly related to the activation of the Keap1-Nrf2 pathway and reduction of apoptosis.	Resveratrol	59-70	kelch-like ECH-associated protein 1	Mus musculus	155-160
33502009-10	2021	Therefore, these findings suggested that the prevention of resveratrol on memory dysfunction induced by METH was possibly related to the activation of the Keap1-Nrf2 pathway and reduction of apoptosis.	Methamphetamine	104-108	kelch-like ECH-associated protein 1	Mus musculus	155-160
33502009-14	2021	In this study, the results of bioinformatics prediction and experimental validation showed that resveratrol might effectively prevent memory impairment via the interaction with Keap1, activation of the Keap1-Nrf2 pathway, and inhibition of DNA damage and apoptotic responses post METH exposure.	Resveratrol	96-107	kelch-like ECH-associated protein 1	Mus musculus	177-182
33502009-14	2021	In this study, the results of bioinformatics prediction and experimental validation showed that resveratrol might effectively prevent memory impairment via the interaction with Keap1, activation of the Keap1-Nrf2 pathway, and inhibition of DNA damage and apoptotic responses post METH exposure.	Resveratrol	96-107	kelch-like ECH-associated protein 1	Mus musculus	202-207
33532181-7	2021	Mechanistically, DT phosphorylated NRF2 at Ser40, rendering its nuclear-import by dissociating from KEAP1 and inhibiting degradation.	Thymidine	17-19	kelch-like ECH-associated protein 1	Mus musculus	100-105
33499152-7	2021	Furthermore, administration of BA alleviated the protein phosphorylation of p38, c-Jun N-terminal kinase (JNK), and extracellular signal-regulated kinases (ERK); decreased the protein expression of kelch-like erythroid cell-derived protein with CNC homology [ECH]-associated protein1 (Keap1); and increased the protein expression of nuclear factor erythroid 2 [NF-E2]-related factor (Nrf2) and heme oxygenase-1 (HO-1) in the spleen.	betulinic acid	31-33	kelch-like ECH-associated protein 1	Mus musculus	285-290
33597885-7	2020	To further support our notion, we performed virtual docking of carveol with Nrf2-keap1 target, and the resultant drug-protein interactions validated the in vivo findings.	carveol	63-70	kelch-like ECH-associated protein 1	Mus musculus	81-86
33468193-0	2021	A combination of herbal compound (SPTC) along with exercise or metformin more efficiently alleviated diabetic complications through down-regulation of stress oxidative pathway upon activating Nrf2-Keap1 axis in AGE rich diet-induced type 2 diabetic mice.	Metformin	63-72	kelch-like ECH-associated protein 1	Mus musculus	197-202
33096251-4	2021	In the presence of ROS, KEAP1 sensor cysteines are directly or indirectly engaged resulting in NRF2 release, nuclear translocation, and activation of its target genes.	Reactive Oxygen Species	19-22	kelch-like ECH-associated protein 1	Mus musculus	24-29
33096251-4	2021	In the presence of ROS, KEAP1 sensor cysteines are directly or indirectly engaged resulting in NRF2 release, nuclear translocation, and activation of its target genes.	Cysteine	37-46	kelch-like ECH-associated protein 1	Mus musculus	24-29
33280250-7	2021	Pterostilbene promoted the binding of Keap1 and p62 which enhanced activation of Nrf2.	pterostilbene	0-13	kelch-like ECH-associated protein 1	Mus musculus	38-43
32219872-6	2021	Keap1 Cys151 mutation significantly reduced Keap1 S-sulfhydration and abolished the hepatoprotective effects of H2 S both in vivo and in vitro.	Hydrogen Sulfide	112-116	kelch-like ECH-associated protein 1	Mus musculus	0-5
32219872-8	2021	Similarly, in carbon tetrachloride (CCl4 )-stimulated mice, GYY4137 increased Keap1 S-sulfhydration, improved liver function, alleviated liver fibrosis, decreased hepatic oxidative stress and activated the Nrf2 signaling pathway, and these effects were abrogated after Keap1 Cys151 mutation.	Carbon Tetrachloride	14-34	kelch-like ECH-associated protein 1	Mus musculus	78-83
32219872-8	2021	Similarly, in carbon tetrachloride (CCl4 )-stimulated mice, GYY4137 increased Keap1 S-sulfhydration, improved liver function, alleviated liver fibrosis, decreased hepatic oxidative stress and activated the Nrf2 signaling pathway, and these effects were abrogated after Keap1 Cys151 mutation.	Carbon Tetrachloride	14-34	kelch-like ECH-associated protein 1	Mus musculus	269-274
32219872-8	2021	Similarly, in carbon tetrachloride (CCl4 )-stimulated mice, GYY4137 increased Keap1 S-sulfhydration, improved liver function, alleviated liver fibrosis, decreased hepatic oxidative stress and activated the Nrf2 signaling pathway, and these effects were abrogated after Keap1 Cys151 mutation.	GYY 4137	60-67	kelch-like ECH-associated protein 1	Mus musculus	78-83
32219872-8	2021	Similarly, in carbon tetrachloride (CCl4 )-stimulated mice, GYY4137 increased Keap1 S-sulfhydration, improved liver function, alleviated liver fibrosis, decreased hepatic oxidative stress and activated the Nrf2 signaling pathway, and these effects were abrogated after Keap1 Cys151 mutation.	GYY 4137	60-67	kelch-like ECH-associated protein 1	Mus musculus	269-274
32219872-9	2021	Moreover, H2 S increased the binding of Nrf2 to the promoter region of LDL-related protein 1 (Lrp1) and consequently upregulated LRP1 expression, but these effects were disrupted by Keap1 Cys151 mutation.	Hydrogen Sulfide	10-14	kelch-like ECH-associated protein 1	Mus musculus	182-187
32219872-10	2021	In conclusion, H2 S-mediated Keap1 S-sulfhydration alleviates liver damage via activation of Nrf2.	Hydrogen	15-17	kelch-like ECH-associated protein 1	Mus musculus	29-34
33241629-9	2021	Moreover, 3 mumol/L acacetin clearly decreased ROS levels and enhanced reductase protein expression through MsrA and Nrf2 pathway through phosphorylation of Nrf2 and degradation of Keap1.	acacetin	20-28	kelch-like ECH-associated protein 1	Mus musculus	181-186
32219872-0	2021	Hydrogen sulfide alleviates liver injury via S-sulfhydrated-Keap1/Nrf2/LRP1 pathway.	Hydrogen Sulfide	0-16	kelch-like ECH-associated protein 1	Mus musculus	60-65
33200472-0	2021	Agaricus blazei polypeptide exerts a protective effect on D-galactose-induced aging mice via the Keap1/Nrf2/ARE and P53/Trim32 signaling pathways.	Galactose	58-69	kelch-like ECH-associated protein 1	Mus musculus	97-102
33189984-6	2021	Songorine activated Nrf2 by promoting Keap1 degradation, having a contribution to enhancing antioxidant defenses.	songorine	0-9	kelch-like ECH-associated protein 1	Mus musculus	38-43
33391509-0	2021	Covalent modification of Keap1 at Cys77 and Cys434 by pubescenoside a suppresses oxidative stress-induced NLRP3 inflammasome activation in myocardial ischemia-reperfusion injury.	pubescenoside A	54-69	kelch-like ECH-associated protein 1	Mus musculus	25-30
32689903-10	2021	Keap1<sup>KD</sup> mice also showed decreased T4 levels in early adult life that were eventually well-compensated over time by increased TSH levels.	Thyrotropin	137-140	kelch-like ECH-associated protein 1	Mus musculus	0-5
33391509-2	2021	Modification of the key reactive cysteine residues in Keap1 affects the interaction between Keap1 and its substrate nuclear factor erythroid 2-related factor 2 (Nrf2), subsequently regulating oxidative stress and NLPR3 inflammasome activation, which are important factors for myocardial ischemia-reperfusion injury (MI/RI).	Cysteine	33-41	kelch-like ECH-associated protein 1	Mus musculus	54-59
33391509-2	2021	Modification of the key reactive cysteine residues in Keap1 affects the interaction between Keap1 and its substrate nuclear factor erythroid 2-related factor 2 (Nrf2), subsequently regulating oxidative stress and NLPR3 inflammasome activation, which are important factors for myocardial ischemia-reperfusion injury (MI/RI).	Cysteine	33-41	kelch-like ECH-associated protein 1	Mus musculus	92-97
33391509-10	2021	Interestingly, PBA targeted Keap1 by selectively covalently binding to conserved cysteine residues, cysteine 77 (Cys77) in the BTB domain and cysteine 434 (Cys434) in the Kelch domain of Keap1, subsequently inhibiting ubiquitination of Nrf2 and activating antioxidant enzymes.	Cysteine	81-89	kelch-like ECH-associated protein 1	Mus musculus	28-33
33391509-10	2021	Interestingly, PBA targeted Keap1 by selectively covalently binding to conserved cysteine residues, cysteine 77 (Cys77) in the BTB domain and cysteine 434 (Cys434) in the Kelch domain of Keap1, subsequently inhibiting ubiquitination of Nrf2 and activating antioxidant enzymes.	Cysteine	100-108	kelch-like ECH-associated protein 1	Mus musculus	28-33
33391509-10	2021	Interestingly, PBA targeted Keap1 by selectively covalently binding to conserved cysteine residues, cysteine 77 (Cys77) in the BTB domain and cysteine 434 (Cys434) in the Kelch domain of Keap1, subsequently inhibiting ubiquitination of Nrf2 and activating antioxidant enzymes.	Cysteine	100-108	kelch-like ECH-associated protein 1	Mus musculus	28-33
33391509-11	2021	Additionally, the cysteines of Keap1 has different degree of activation by PBA as follows: Cys77 > Cys434 > Cys23 > Cys38 > Cys226 > Cys273, which further elucidates the cysteine sensitivity of Keap1.	Cysteine	18-27	kelch-like ECH-associated protein 1	Mus musculus	31-36
33391509-11	2021	Additionally, the cysteines of Keap1 has different degree of activation by PBA as follows: Cys77 > Cys434 > Cys23 > Cys38 > Cys226 > Cys273, which further elucidates the cysteine sensitivity of Keap1.	Cysteine	18-27	kelch-like ECH-associated protein 1	Mus musculus	194-199
33391509-11	2021	Additionally, the cysteines of Keap1 has different degree of activation by PBA as follows: Cys77 > Cys434 > Cys23 > Cys38 > Cys226 > Cys273, which further elucidates the cysteine sensitivity of Keap1.	pubescenoside A	75-78	kelch-like ECH-associated protein 1	Mus musculus	31-36
33391509-11	2021	Additionally, the cysteines of Keap1 has different degree of activation by PBA as follows: Cys77 > Cys434 > Cys23 > Cys38 > Cys226 > Cys273, which further elucidates the cysteine sensitivity of Keap1.	pubescenoside A	75-78	kelch-like ECH-associated protein 1	Mus musculus	194-199
33391509-11	2021	Additionally, the cysteines of Keap1 has different degree of activation by PBA as follows: Cys77 > Cys434 > Cys23 > Cys38 > Cys226 > Cys273, which further elucidates the cysteine sensitivity of Keap1.	Cysteine	18-26	kelch-like ECH-associated protein 1	Mus musculus	31-36
33391509-11	2021	Additionally, the cysteines of Keap1 has different degree of activation by PBA as follows: Cys77 > Cys434 > Cys23 > Cys38 > Cys226 > Cys273, which further elucidates the cysteine sensitivity of Keap1.	Cysteine	18-26	kelch-like ECH-associated protein 1	Mus musculus	194-199
32866756-4	2020	Our efforts led to the potent small molecule KEAP1-NRF2 inhibitor, 20c, which exhibited a Kd of 24 nM to KEAP1 and an IC50 of 75 nM in disrupting KEAP1-NRF2 interaction.	CHEMBL1229792	67-70	kelch-like ECH-associated protein 1	Mus musculus	105-110
33298178-10	2020	The autophagy/Keap1/Nrf2 signal in H2O2-treated BM-MSC/sh-Mst1 was also measured.	Hydrogen Peroxide	35-39	kelch-like ECH-associated protein 1	Mus musculus	14-19
32866756-0	2020	Discovery of 2-oxy-2-phenylacetic acid substituted naphthalene sulfonamide derivatives as potent KEAP1-NRF2 protein-protein interaction inhibitors for inflammatory conditions.	2-oxy-2-phenylacetic acid	13-38	kelch-like ECH-associated protein 1	Mus musculus	97-102
33490940-2	2021	We have identified A-1396076, a potent and selective NRF2 activator with demonstrated KEAP1 binding and modulation of cellular NRF2 mediated effects.	a-1396076	19-28	kelch-like ECH-associated protein 1	Mus musculus	86-91
33352854-9	2020	In addition, DMF treatment reduced the protein expression of kelch-like ECH-associated protein 1 (Keap-1) in lung lysates from DEP-exposed mice, whereas total nuclear factor kappaB (NF-kappaB) p65 expression was decreased below baseline in the DEP + DMF group compared to both the control and DEP groups.	Dimethyl Fumarate	13-16	kelch-like ECH-associated protein 1	Mus musculus	61-96
33352854-9	2020	In addition, DMF treatment reduced the protein expression of kelch-like ECH-associated protein 1 (Keap-1) in lung lysates from DEP-exposed mice, whereas total nuclear factor kappaB (NF-kappaB) p65 expression was decreased below baseline in the DEP + DMF group compared to both the control and DEP groups.	Dimethyl Fumarate	13-16	kelch-like ECH-associated protein 1	Mus musculus	98-104
33298178-13	2020	Moreover, the antioxidant pathway Keap1/Nrf2 was also blocked when autophagy was inhibited by the autophagy inhibitor 3-MA.	3-methyladenine	118-122	kelch-like ECH-associated protein 1	Mus musculus	34-39
32866756-0	2020	Discovery of 2-oxy-2-phenylacetic acid substituted naphthalene sulfonamide derivatives as potent KEAP1-NRF2 protein-protein interaction inhibitors for inflammatory conditions.	naphthalenesulfonamide	51-74	kelch-like ECH-associated protein 1	Mus musculus	97-102
32866756-3	2020	We reported here the first identification of a series of 2-oxy-2-phenylacetic acid substituted naphthalene sulfonamide derivatives as potent KEAP1-NRF2 inhibitors.	2-oxy-2-phenylacetic acid	57-82	kelch-like ECH-associated protein 1	Mus musculus	141-146
32866756-3	2020	We reported here the first identification of a series of 2-oxy-2-phenylacetic acid substituted naphthalene sulfonamide derivatives as potent KEAP1-NRF2 inhibitors.	naphthalene	95-106	kelch-like ECH-associated protein 1	Mus musculus	141-146
32866756-3	2020	We reported here the first identification of a series of 2-oxy-2-phenylacetic acid substituted naphthalene sulfonamide derivatives as potent KEAP1-NRF2 inhibitors.	Sulfonamides	107-118	kelch-like ECH-associated protein 1	Mus musculus	141-146
32866756-4	2020	Our efforts led to the potent small molecule KEAP1-NRF2 inhibitor, 20c, which exhibited a Kd of 24 nM to KEAP1 and an IC50 of 75 nM in disrupting KEAP1-NRF2 interaction.	CHEMBL1229792	67-70	kelch-like ECH-associated protein 1	Mus musculus	105-110
32860805-0	2020	Dihydrokaempferol (DHK) ameliorates severe acute pancreatitis (SAP) via Keap1/Nrf2 pathway.	aromadedrin	0-17	kelch-like ECH-associated protein 1	Mus musculus	72-77
32866756-4	2020	Our efforts led to the potent small molecule KEAP1-NRF2 inhibitor, 20c, which exhibited a Kd of 24 nM to KEAP1 and an IC50 of 75 nM in disrupting KEAP1-NRF2 interaction.	CHEMBL1229792	67-70	kelch-like ECH-associated protein 1	Mus musculus	45-50
32893883-9	2020	Gene ontology analysis suggested that Nrf2 KO-changed proteins are involved in metabolism of oxidoreduction coenzymes, purine ribonucleoside triphosphate, ATP, and propanoate, which are considered as the basal function of Nrf2, while Keap1 KO-changed proteins are involved in cellular detoxification, NADP metabolism, glutathione metabolism, and the electron transport chain, which belong to the induced effect of Nrf2.	Glutathione	318-329	kelch-like ECH-associated protein 1	Mus musculus	234-239
32893883-9	2020	Gene ontology analysis suggested that Nrf2 KO-changed proteins are involved in metabolism of oxidoreduction coenzymes, purine ribonucleoside triphosphate, ATP, and propanoate, which are considered as the basal function of Nrf2, while Keap1 KO-changed proteins are involved in cellular detoxification, NADP metabolism, glutathione metabolism, and the electron transport chain, which belong to the induced effect of Nrf2.	purine	119-125	kelch-like ECH-associated protein 1	Mus musculus	234-239
32893883-9	2020	Gene ontology analysis suggested that Nrf2 KO-changed proteins are involved in metabolism of oxidoreduction coenzymes, purine ribonucleoside triphosphate, ATP, and propanoate, which are considered as the basal function of Nrf2, while Keap1 KO-changed proteins are involved in cellular detoxification, NADP metabolism, glutathione metabolism, and the electron transport chain, which belong to the induced effect of Nrf2.	ribonucleoside triphosphate	126-153	kelch-like ECH-associated protein 1	Mus musculus	234-239
32893883-9	2020	Gene ontology analysis suggested that Nrf2 KO-changed proteins are involved in metabolism of oxidoreduction coenzymes, purine ribonucleoside triphosphate, ATP, and propanoate, which are considered as the basal function of Nrf2, while Keap1 KO-changed proteins are involved in cellular detoxification, NADP metabolism, glutathione metabolism, and the electron transport chain, which belong to the induced effect of Nrf2.	Adenosine Triphosphate	155-158	kelch-like ECH-associated protein 1	Mus musculus	234-239
32893883-9	2020	Gene ontology analysis suggested that Nrf2 KO-changed proteins are involved in metabolism of oxidoreduction coenzymes, purine ribonucleoside triphosphate, ATP, and propanoate, which are considered as the basal function of Nrf2, while Keap1 KO-changed proteins are involved in cellular detoxification, NADP metabolism, glutathione metabolism, and the electron transport chain, which belong to the induced effect of Nrf2.	Propionates	164-174	kelch-like ECH-associated protein 1	Mus musculus	234-239
32893883-9	2020	Gene ontology analysis suggested that Nrf2 KO-changed proteins are involved in metabolism of oxidoreduction coenzymes, purine ribonucleoside triphosphate, ATP, and propanoate, which are considered as the basal function of Nrf2, while Keap1 KO-changed proteins are involved in cellular detoxification, NADP metabolism, glutathione metabolism, and the electron transport chain, which belong to the induced effect of Nrf2.	NADP	301-305	kelch-like ECH-associated protein 1	Mus musculus	234-239
33201834-4	2020	Moreover, in vivo experiments also revealed that CdSe/ZnS QDs treatment obviously increased kidney weight coefficient, damaged the kidney function, as well as induced inflammatory response and inhibited the activation of NRF2/Keap1 pathway in kidney tissues of mice.	cdse	49-53	kelch-like ECH-associated protein 1	Mus musculus	226-231
33201834-4	2020	Moreover, in vivo experiments also revealed that CdSe/ZnS QDs treatment obviously increased kidney weight coefficient, damaged the kidney function, as well as induced inflammatory response and inhibited the activation of NRF2/Keap1 pathway in kidney tissues of mice.	zns qds	54-61	kelch-like ECH-associated protein 1	Mus musculus	226-231
33201834-5	2020	CONCLUSIONS: CdSe/ZnS QDs exhibited obvious nephrotoxicity by mediating oxidative damage and inflammatory response in vitro and in vivo via NRF2/Keap1 pathway.	cdse	13-17	kelch-like ECH-associated protein 1	Mus musculus	145-150
33201834-5	2020	CONCLUSIONS: CdSe/ZnS QDs exhibited obvious nephrotoxicity by mediating oxidative damage and inflammatory response in vitro and in vivo via NRF2/Keap1 pathway.	Zinc	18-21	kelch-like ECH-associated protein 1	Mus musculus	145-150
32860805-0	2020	Dihydrokaempferol (DHK) ameliorates severe acute pancreatitis (SAP) via Keap1/Nrf2 pathway.	aromadedrin	19-22	kelch-like ECH-associated protein 1	Mus musculus	72-77
32860805-11	2020	The results revealed that ad-Keap1suppressed the nuclear translocation of Nrf2 which is enhanced by DHK, and suppressed the antioxidative functionality of DHK both in mice and cell models.	aromadedrin	100-103	kelch-like ECH-associated protein 1	Mus musculus	29-34
32860805-11	2020	The results revealed that ad-Keap1suppressed the nuclear translocation of Nrf2 which is enhanced by DHK, and suppressed the antioxidative functionality of DHK both in mice and cell models.	aromadedrin	155-158	kelch-like ECH-associated protein 1	Mus musculus	29-34
31913745-6	2020	Furthermore, we identified that SQSTM1 induces ULK1 (unc-51 like autophagy activating kinase 1) phosphorylation by facilitating the interaction between AMPK (AMP-activated protein kinase) and ULK1, leading to macroautophagy/autophagy induction, followed by KEAP1 degradation and NFE2L2 activation.	Adenosine Monophosphate	152-155	kelch-like ECH-associated protein 1	Mus musculus	257-262
33197602-9	2021	Furthermore, overexpression of Keap1 and beta-cateninin in H2O2-treated NMVCs with recovered miR-200a elevated inflammation and apoptosis, respectively.	Hydrogen Peroxide	59-63	kelch-like ECH-associated protein 1	Mus musculus	31-36
33197602-10	2021	CONCLUSION: The results showed that miR-200a expression was inhibited in murine cardiomyocytes due to H2O2 stress in MI cardiac tissues and overexpressed miR-200a could protect the cells from death by regulating the Keap1/Nrf2 and beta-catenin signal transduction pathways.	Hydrogen Peroxide	102-106	kelch-like ECH-associated protein 1	Mus musculus	216-221
33197602-4	2021	METHODS: We observed down-regulation of miR-200a levels and up-regulation of Keap1 and beta-catenin levels in H2O2-treated newborn murine ventricular cardiomyocytes (NMVCs) and the infarcted heart tissues of MI mouse models, compared to the non-treated NMVCs and normal heart tissues of healthy mice.	Hydrogen Peroxide	110-114	kelch-like ECH-associated protein 1	Mus musculus	77-82
33197602-8	2021	Moreover, miR-200a inhibited up-regulation of Keap1 and beta-catenin expression in H2O2-treated NMVCs by directly binding with the 3"-UTR regions of both Keap1 and beta-catenin.	Hydrogen Peroxide	83-87	kelch-like ECH-associated protein 1	Mus musculus	46-51
33197602-8	2021	Moreover, miR-200a inhibited up-regulation of Keap1 and beta-catenin expression in H2O2-treated NMVCs by directly binding with the 3"-UTR regions of both Keap1 and beta-catenin.	Hydrogen Peroxide	83-87	kelch-like ECH-associated protein 1	Mus musculus	154-159
33197602-8	2021	Moreover, miR-200a inhibited up-regulation of Keap1 and beta-catenin expression in H2O2-treated NMVCs by directly binding with the 3"-UTR regions of both Keap1 and beta-catenin.	nmvcs	96-101	kelch-like ECH-associated protein 1	Mus musculus	46-51
33197602-8	2021	Moreover, miR-200a inhibited up-regulation of Keap1 and beta-catenin expression in H2O2-treated NMVCs by directly binding with the 3"-UTR regions of both Keap1 and beta-catenin.	nmvcs	96-101	kelch-like ECH-associated protein 1	Mus musculus	154-159
33145362-3	2020	Nrf2/Keap1 is involved in oxidative stress, and the western blotting data exhibited that dietary methionine markedly increased Keap1 abundance, while failed to influence the Nrf2 signal.	Methionine	97-107	kelch-like ECH-associated protein 1	Mus musculus	5-10
32800555-3	2020	Using the common AD model APP/PS1 mice, it was found that the expression of Keap1 (a negative regulatory factor of Nrf2), the protein level of cytoplasmic Nrf2 and the content of MDA were increased significantly, while the mRNA level of Nrf2, the expression of Nrf2 in nucleus and the contents of SOD and GSH-Px were decreased significantly.	Glutathione	305-308	kelch-like ECH-associated protein 1	Mus musculus	76-81
32800555-4	2020	APS treatment significantly increased the expression of Nrf2 in the nucleus but decreased its expression in the cytoplasm, and restored the expression levels of Keap1, SOD, GSH-Px and MDA.	aps	0-3	kelch-like ECH-associated protein 1	Mus musculus	161-166
33145362-3	2020	Nrf2/Keap1 is involved in oxidative stress, and the western blotting data exhibited that dietary methionine markedly increased Keap1 abundance, while failed to influence the Nrf2 signal.	Methionine	97-107	kelch-like ECH-associated protein 1	Mus musculus	127-132
33103077-3	2020	Using proteomics and lipidomics, we show that genetic downregulation of Keap1 in mice, and the consequent Nrf2 activation to pharmacologically relevant levels, leads to upregulation of carboxylesterase 1 (Ces1) and acyl-CoA oxidase 2 (Acox2), decreases triglyceride levels, and alters the lipidome.	Triglycerides	253-265	kelch-like ECH-associated protein 1	Mus musculus	72-77
33044988-0	2020	Kahweol activates the Nrf2/HO-1 pathway by decreasing Keap1 expression independently of p62 and autophagy pathways.	kahweol	0-7	kelch-like ECH-associated protein 1	Mus musculus	54-59
33044988-5	2020	Here, we examined the role of Keap1 regulation in the effect of kahweol on the Nrf2/HO-1 pathway in hepatocytes.	kahweol	64-71	kelch-like ECH-associated protein 1	Mus musculus	30-35
33044988-7	2020	In addition, kahweol reduced Keap1 protein levels significantly without decreasing Keap1 mRNA levels.	kahweol	13-20	kelch-like ECH-associated protein 1	Mus musculus	29-34
33044988-8	2020	Although regulation of the Keap1-Nrf2-pathway by p62-dependent autophagy is well known, we confirmed here that the reduction of Keap1 protein levels by kahweol does not involve p62-dependent autophagy degradation or ubiquitination.	kahweol	152-159	kelch-like ECH-associated protein 1	Mus musculus	128-133
33044988-9	2020	In conclusion, kahweol increases the expression of Nrf2 in hepatocytes by inhibiting translation of the Keap1 mRNA.	kahweol	15-22	kelch-like ECH-associated protein 1	Mus musculus	104-109
32580013-4	2020	KKC080106 was able to activate Nrf2 signaling as it increases the cellular levels of Nrf2, binds to the Nrf2 inhibitor protein Keap1, and causes the accumulation of nuclear Nrf2.	kkc080106	0-9	kelch-like ECH-associated protein 1	Mus musculus	127-132
32902980-0	2020	Design, Synthesis and Structure-Activity Relationships of Indoline-Based Kelch-like ECH Associated Protein 1-Nuclear Factor (Erythroid-derived 2)-like 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitors.	indoline	58-66	kelch-like ECH-associated protein 1	Mus musculus	154-159
32902980-2	2020	Here, we describe the design, synthesis, and structure-activity relationships (SAR) of indoline based compounds as potent Keap1-Nrf2 PPI inhibitors.	indoline	87-95	kelch-like ECH-associated protein 1	Mus musculus	122-127
32902980-6	2020	Collectively, we reported here a novel indoline-based Keap1-Nrf2 PPI inhibitor as potential cardioprotective agent.	indoline	39-47	kelch-like ECH-associated protein 1	Mus musculus	54-59
32020639-2	2020	High glucose (HG) induces oxidative injury and apoptosis in retinal ganglion cells (RGCs), serving as a primary pathological mechanism of DR. MIND4-17 activates nuclear-factor-E2-related factor 2 (Nrf2) signaling via modifying one cysteine (C151) residue of Kelch-like ECH-associated protein 1 (Keap1).	Glucose	5-12	kelch-like ECH-associated protein 1	Mus musculus	258-293
32020639-2	2020	High glucose (HG) induces oxidative injury and apoptosis in retinal ganglion cells (RGCs), serving as a primary pathological mechanism of DR. MIND4-17 activates nuclear-factor-E2-related factor 2 (Nrf2) signaling via modifying one cysteine (C151) residue of Kelch-like ECH-associated protein 1 (Keap1).	Glucose	5-12	kelch-like ECH-associated protein 1	Mus musculus	295-300
32949969-12	2020	As redox and other intracellular signaling pathways are critically affected by O2, the development of antioxidant therapies targeting the Keap1-Nrf2 defense pathway in treatment of ischemia-reperfusion injury in stroke, coronary and renal disease will require in vitro studies conducted under well-defined O2 levels.	Oxygen	79-81	kelch-like ECH-associated protein 1	Mus musculus	138-143
32949969-12	2020	As redox and other intracellular signaling pathways are critically affected by O2, the development of antioxidant therapies targeting the Keap1-Nrf2 defense pathway in treatment of ischemia-reperfusion injury in stroke, coronary and renal disease will require in vitro studies conducted under well-defined O2 levels.	Oxygen	306-308	kelch-like ECH-associated protein 1	Mus musculus	138-143
32951003-8	2020	We further revealed that (+)-CLA specifically reacted with the Cys-151 residue of Keap1, which blocked Nrf2 ubiquitylation and resulted in an increased Nrf2 stability, thereby leading to the activation of the Keap1-Nrf2 pathway to prevent drug-induced hepatocyte ferroptosis.	Cysteine	63-66	kelch-like ECH-associated protein 1	Mus musculus	82-87
32951003-8	2020	We further revealed that (+)-CLA specifically reacted with the Cys-151 residue of Keap1, which blocked Nrf2 ubiquitylation and resulted in an increased Nrf2 stability, thereby leading to the activation of the Keap1-Nrf2 pathway to prevent drug-induced hepatocyte ferroptosis.	Cysteine	63-66	kelch-like ECH-associated protein 1	Mus musculus	209-214
32916869-0	2020	Anti-Inflammatory Activity of Kurarinone Involves Induction of HO-1 via the KEAP1/Nrf2 Pathway.	kurarinone	30-40	kelch-like ECH-associated protein 1	Mus musculus	76-81
32943614-1	2020	Four-octyl itaconate (4-OI) is the cell-permeable derivative of itaconate that can activate Nrf2 signaling by alkylating Keap1"s cysteine residues.	four-octyl itaconate	0-20	kelch-like ECH-associated protein 1	Mus musculus	121-126
32943614-1	2020	Four-octyl itaconate (4-OI) is the cell-permeable derivative of itaconate that can activate Nrf2 signaling by alkylating Keap1"s cysteine residues.	4-oi	22-26	kelch-like ECH-associated protein 1	Mus musculus	121-126
32943614-1	2020	Four-octyl itaconate (4-OI) is the cell-permeable derivative of itaconate that can activate Nrf2 signaling by alkylating Keap1"s cysteine residues.	itaconic acid	11-20	kelch-like ECH-associated protein 1	Mus musculus	121-126
32943614-1	2020	Four-octyl itaconate (4-OI) is the cell-permeable derivative of itaconate that can activate Nrf2 signaling by alkylating Keap1"s cysteine residues.	Cysteine	129-137	kelch-like ECH-associated protein 1	Mus musculus	121-126
32916869-5	2020	Mechanistically, kurarinone downregulated the expression of kelch-like ECH-associated protein 1 (KEAP1), subsequently leading to the activation of Nrf2.	kurarinone	17-27	kelch-like ECH-associated protein 1	Mus musculus	60-95
32916869-5	2020	Mechanistically, kurarinone downregulated the expression of kelch-like ECH-associated protein 1 (KEAP1), subsequently leading to the activation of Nrf2.	kurarinone	17-27	kelch-like ECH-associated protein 1	Mus musculus	97-102
32916869-8	2020	These results indicate that kurarinone activates the KEAP1/Nrf2 pathway to induce HO-1 expression, thereby exerting immunosuppressive effects.	kurarinone	28-38	kelch-like ECH-associated protein 1	Mus musculus	53-58
32574955-10	2020	Mechanistically, itaconate inhibited vascular inflammation by enabling Nrf2 to function as a transcriptional repressor of downstream inflammatory genes via alkylation of Keap1.	itaconic acid	17-26	kelch-like ECH-associated protein 1	Mus musculus	170-175
32823937-4	2020	The unpredicted outcome of the Keap1-null mutation in mice allowed us to revisit the basic principle of the biological process of keratinization: sulfur metabolism establishes unparalleled cytoprotection in the body wall of terrestrial mammals.	Sulfur	146-152	kelch-like ECH-associated protein 1	Mus musculus	31-36
32823937-5	2020	We summarize the recent understanding of the KEAP1/NRF2 signaling pathway, which is a thiol-based sensor-effector apparatus, with particular focuses on epidermal differentiation in the context of the gene-environment interaction, the structure/function principles involved in KEAP1/NRF2 signaling, lessons from mouse models, and their pathological implications.	Sulfhydryl Compounds	86-91	kelch-like ECH-associated protein 1	Mus musculus	45-50
32298752-0	2020	Natural phenylethanoid glycosides isolated from Callicarpa kwangtungensis suppressed lipopolysaccharide-mediated inflammatory response via activating Keap1/Nrf2/HO-1 pathway in RAW 264.7 macrophages cell.	phenylethanoid	8-22	kelch-like ECH-associated protein 1	Mus musculus	150-155
32298752-0	2020	Natural phenylethanoid glycosides isolated from Callicarpa kwangtungensis suppressed lipopolysaccharide-mediated inflammatory response via activating Keap1/Nrf2/HO-1 pathway in RAW 264.7 macrophages cell.	Glycosides	23-33	kelch-like ECH-associated protein 1	Mus musculus	150-155
32298752-5	2020	Further, the effective anti-inflammatory mechanism of two PhGs (forsythoside B and alyssonoside) via Keap1/Nrf2/OH-1 signaling pathway was explored.	phgs	58-62	kelch-like ECH-associated protein 1	Mus musculus	101-106
32298752-5	2020	Further, the effective anti-inflammatory mechanism of two PhGs (forsythoside B and alyssonoside) via Keap1/Nrf2/OH-1 signaling pathway was explored.	forsythoside B	64-78	kelch-like ECH-associated protein 1	Mus musculus	101-106
32298752-5	2020	Further, the effective anti-inflammatory mechanism of two PhGs (forsythoside B and alyssonoside) via Keap1/Nrf2/OH-1 signaling pathway was explored.	alyssonoside	83-95	kelch-like ECH-associated protein 1	Mus musculus	101-106
32298752-6	2020	The experiments confirmed forsythoside B and alyssonoside could act as the inhibitors of Keap1-Nrf2 interaction, then activated the nuclear translocation of Nrf2 and promoted the upregulated protein expression of heme oxygenase-1 (HO-1) and quinone oxidoreductase 1 (NQO1), finally suppressed LPS-induced inflammatory response in RAW 264.7 cells.	forsythoside B	26-40	kelch-like ECH-associated protein 1	Mus musculus	89-94
32298752-6	2020	The experiments confirmed forsythoside B and alyssonoside could act as the inhibitors of Keap1-Nrf2 interaction, then activated the nuclear translocation of Nrf2 and promoted the upregulated protein expression of heme oxygenase-1 (HO-1) and quinone oxidoreductase 1 (NQO1), finally suppressed LPS-induced inflammatory response in RAW 264.7 cells.	alyssonoside	45-57	kelch-like ECH-associated protein 1	Mus musculus	89-94
32298752-7	2020	Molecular modeling exhibited potential interaction between PhGs and the Nrf2 binding site in Kelch-like ECH-association protein 1 (Keap1), and hydrogen bonds played a crucial role for the binding of PhGs with Keap1.	phgs	59-63	kelch-like ECH-associated protein 1	Mus musculus	93-129
32298752-7	2020	Molecular modeling exhibited potential interaction between PhGs and the Nrf2 binding site in Kelch-like ECH-association protein 1 (Keap1), and hydrogen bonds played a crucial role for the binding of PhGs with Keap1.	phgs	59-63	kelch-like ECH-associated protein 1	Mus musculus	131-136
32298752-7	2020	Molecular modeling exhibited potential interaction between PhGs and the Nrf2 binding site in Kelch-like ECH-association protein 1 (Keap1), and hydrogen bonds played a crucial role for the binding of PhGs with Keap1.	Hydrogen	143-151	kelch-like ECH-associated protein 1	Mus musculus	209-214
32742327-0	2020	Metformin attenuates cardiac remodeling in mice through the Nrf2/Keap1 signaling pathway.	Metformin	0-9	kelch-like ECH-associated protein 1	Mus musculus	65-70
32802189-0	2020	Epigenetic repression of miR-17 contributed to di(2-ethylhexyl) phthalate-triggered insulin resistance by targeting Keap1-Nrf2/miR-200a axis in skeletal muscle.	Diethylhexyl Phthalate	47-73	kelch-like ECH-associated protein 1	Mus musculus	116-121
32802189-8	2020	DEHP suppressed miR-17 to disrupt the Keap1-Nrf2 redox system and to activate oxidative stress-responsive Txnip in skeletal muscle.	Diethylhexyl Phthalate	0-4	kelch-like ECH-associated protein 1	Mus musculus	38-43
31712142-6	2020	Importantly, our further results in vitro suggested that Myr remarkably attenuated H2O2-triggered hepatotoxicity and ROS generation, activated Keap1-Nrf2/HO-1 and AMPK/ACC signaling pathway.	myricetin	57-60	kelch-like ECH-associated protein 1	Mus musculus	143-148
31712142-6	2020	Importantly, our further results in vitro suggested that Myr remarkably attenuated H2O2-triggered hepatotoxicity and ROS generation, activated Keap1-Nrf2/HO-1 and AMPK/ACC signaling pathway.	Water	83-87	kelch-like ECH-associated protein 1	Mus musculus	143-148
31712142-7	2020	However, Myr-enhanced the expression of HO-1 and Nrf2 protein was reversed by Keap1-overexpression, Nrf2-null and AMPK inhibitor.	myricetin	9-12	kelch-like ECH-associated protein 1	Mus musculus	78-83
32534099-5	2020	While SFN significantly (p < 0.05) induced NRF2, KEAP1 and BACH1, NAC attenuated SFN-induced NRF2, KEAP1 and BACH1.	Acetylcysteine	66-69	kelch-like ECH-associated protein 1	Mus musculus	99-104
32534099-6	2020	The down-regulation of KEAP1 by NAC was of interest, as Keap1 is markedly increased in the MCK conditional frataxin knockout (MCK KO) mouse model and this could lead to the decreased Nrf2 levels.	Acetylcysteine	32-35	kelch-like ECH-associated protein 1	Mus musculus	23-28
32534099-6	2020	The down-regulation of KEAP1 by NAC was of interest, as Keap1 is markedly increased in the MCK conditional frataxin knockout (MCK KO) mouse model and this could lead to the decreased Nrf2 levels.	Acetylcysteine	32-35	kelch-like ECH-associated protein 1	Mus musculus	56-61
32823168-0	2020	Formononetin ameliorates oxaliplatin-induced peripheral neuropathy via the KEAP1-NRF2-GSTP1 axis.	formononetin	0-12	kelch-like ECH-associated protein 1	Mus musculus	75-80
32823168-0	2020	Formononetin ameliorates oxaliplatin-induced peripheral neuropathy via the KEAP1-NRF2-GSTP1 axis.	Oxaliplatin	25-36	kelch-like ECH-associated protein 1	Mus musculus	75-80
32908623-0	2020	Polysaccharides from Hemp Seed Protect against Cyclophosphamide-Induced Intestinal Oxidative Damage via Nrf2-Keap1 Signaling Pathway in Mice.	Polysaccharides	0-15	kelch-like ECH-associated protein 1	Mus musculus	109-114
32908623-0	2020	Polysaccharides from Hemp Seed Protect against Cyclophosphamide-Induced Intestinal Oxidative Damage via Nrf2-Keap1 Signaling Pathway in Mice.	Cyclophosphamide	47-63	kelch-like ECH-associated protein 1	Mus musculus	109-114
32908623-7	2020	Collectively, our findings indicated that HSP had protective effects on intestinal oxidative damage induced by Cy in mice, and its mechanism might be related to the activation of Nrf2-Keap1 signaling pathway.	Cyclophosphamide	111-113	kelch-like ECH-associated protein 1	Mus musculus	184-189
32823691-0	2020	Protective Effect of Low Molecular Weight Peptides from Solenocera crassicornis Head against Cyclophosphamide-Induced Nephrotoxicity in Mice via the Keap1/Nrf2 Pathway.	Cyclophosphamide	93-109	kelch-like ECH-associated protein 1	Mus musculus	149-154
32758258-12	2020	These beneficial effects were mediated at least in part by the Keap1/Nrf2/HO-1 pathway, since they were reversed by the pathway inhibitor brusatol.	brusatol	138-146	kelch-like ECH-associated protein 1	Mus musculus	63-68
32802189-11	2020	Conclusions: The miR-17/Keap1-Nrf2/miR-200a axis contributed to DEHP-induced insulin resistance.	Diethylhexyl Phthalate	64-68	kelch-like ECH-associated protein 1	Mus musculus	24-29
32574955-12	2020	In addition, Keap1 overexpression significantly promoted Ang II-induced AAA formation, which was inhibited by itaconate.	itaconic acid	110-119	kelch-like ECH-associated protein 1	Mus musculus	13-18
32353588-9	2020	Mangiferin degraded Keap1 to promote Nrf2 protein accumulation by improving its stability, leading to Nrf2 activation.	mangiferin	0-10	kelch-like ECH-associated protein 1	Mus musculus	20-25
32714485-10	2020	Mechanistically, Sal B dramatically promoted Nrf2 nuclear translocation through the downregulation of Keap1, which resulted in the expression of antioxidant enzymes, including HO-1 and NQO1, thereby counteracted the oxidative damage in response to CA/CPR.	salvianolic acid B	17-22	kelch-like ECH-associated protein 1	Mus musculus	102-107
32422542-5	2020	In our assay, the test compounds can target either ETGE or DLG binding site, therefore facilitating the exploration of diverse Keap1-Nrf2 inhibitors.	etge	51-55	kelch-like ECH-associated protein 1	Mus musculus	127-132
32422542-5	2020	In our assay, the test compounds can target either ETGE or DLG binding site, therefore facilitating the exploration of diverse Keap1-Nrf2 inhibitors.	Glyceraldehyde	59-62	kelch-like ECH-associated protein 1	Mus musculus	127-132
32422542-6	2020	Three FDA-approved drugs, zafirlukast, dutasteride and ketoconazole, were found to inhibit the Keap1-Nrf2 interaction with IC50 of 5.87, 2.81 and 1.67 muM, respectively.	zafirlukast	26-37	kelch-like ECH-associated protein 1	Mus musculus	95-100
32422542-6	2020	Three FDA-approved drugs, zafirlukast, dutasteride and ketoconazole, were found to inhibit the Keap1-Nrf2 interaction with IC50 of 5.87, 2.81 and 1.67 muM, respectively.	Dutasteride	39-50	kelch-like ECH-associated protein 1	Mus musculus	95-100
32422542-6	2020	Three FDA-approved drugs, zafirlukast, dutasteride and ketoconazole, were found to inhibit the Keap1-Nrf2 interaction with IC50 of 5.87, 2.81 and 1.67 muM, respectively.	Ketoconazole	55-67	kelch-like ECH-associated protein 1	Mus musculus	95-100
32532087-0	2020	Attenuation of Lipopolysaccharide-Induced Acute Lung Injury by Hispolon in Mice, Through Regulating the TLR4/PI3K/Akt/mTOR and Keap1/Nrf2/HO-1 Pathways, and Suppressing Oxidative Stress-Mediated ER Stress-Induced Apoptosis and Autophagy.	hispolon	63-71	kelch-like ECH-associated protein 1	Mus musculus	127-132
32338864-0	2020	Obtusaquinone is a cysteine modifying compound that targets Keap1 for degradation.	obtusaquinone	0-13	kelch-like ECH-associated protein 1	Mus musculus	60-65
32338864-0	2020	Obtusaquinone is a cysteine modifying compound that targets Keap1 for degradation.	Cysteine	19-27	kelch-like ECH-associated protein 1	Mus musculus	60-65
32338864-3	2020	We here show that OBT binds to cysteine residues with particular affinity to cysteine-rich Keap1, a member of the CUL3 ubiquitin ligase complex.	Cysteine	31-39	kelch-like ECH-associated protein 1	Mus musculus	91-96
32338864-3	2020	We here show that OBT binds to cysteine residues with particular affinity to cysteine-rich Keap1, a member of the CUL3 ubiquitin ligase complex.	Cysteine	77-85	kelch-like ECH-associated protein 1	Mus musculus	91-96
32365333-0	2020	Lycopene prevents carcinogen-induced cutaneous tumor by enhancing activation of the Nrf2 pathway through p62-triggered autophagic Keap1 degradation.	Lycopene	0-8	kelch-like ECH-associated protein 1	Mus musculus	130-135
32454347-0	2020	Enhanced Keap1-Nrf2/Trx-1 axis by daphnetin protects against oxidative stress-driven hepatotoxicity via inhibiting ASK1/JNK and Txnip/NLRP3 inflammasome activation.	daphnetin	34-43	kelch-like ECH-associated protein 1	Mus musculus	9-14
32437336-0	2020	ZJ01, a Small Molecule Inhibitor of the Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction, Reduces Hyperoxic Acute Lung Injury in a Mouse Model.	zj01	0-4	kelch-like ECH-associated protein 1	Mus musculus	121-126
32437336-13	2020	CONCLUSIONS ZJ01, a Keap1-Nrf2 PPI inhibitor, reduced hyperoxic ALI in a mouse model through the Nrf2/HO-1 pathway.	zj01	12-16	kelch-like ECH-associated protein 1	Mus musculus	20-25
31760092-5	2020	Our results indicate that DHS blocks Nrf2 ubiquitylation through specifically reacting with Cys151 cysteine in Keap1 protein to activate Nrf2-regulated defensive response, and thus enhances intracellular antioxidant capability.	4,4'-dihydroxystilbene	26-29	kelch-like ECH-associated protein 1	Mus musculus	111-116
31760092-5	2020	Our results indicate that DHS blocks Nrf2 ubiquitylation through specifically reacting with Cys151 cysteine in Keap1 protein to activate Nrf2-regulated defensive response, and thus enhances intracellular antioxidant capability.	cysteinylcysteine	92-95	kelch-like ECH-associated protein 1	Mus musculus	111-116
31760092-5	2020	Our results indicate that DHS blocks Nrf2 ubiquitylation through specifically reacting with Cys151 cysteine in Keap1 protein to activate Nrf2-regulated defensive response, and thus enhances intracellular antioxidant capability.	Cysteine	99-107	kelch-like ECH-associated protein 1	Mus musculus	111-116
32365333-10	2020	In conclusion, our study provides preclinical evidence of the chemopreventive effects of lycopene on cutaneous tumors and reveals the mechanistic link between lycopene"s stimulation of Nrf2 signaling pathway and p62-mediated degradation of Keap1 via the autophagy-lysosomal pathway.	Lycopene	159-167	kelch-like ECH-associated protein 1	Mus musculus	240-245
31552548-0	2020	Oridonin attenuates carrageenan-induced pleurisy via activation of the KEAP-1/Nrf2 pathway and inhibition of the TXNIP/NLRP3 and NF-kappaB pathway in mice.	oridonin	0-8	kelch-like ECH-associated protein 1	Mus musculus	71-77
32032607-5	2020	Therefore, we searched for novel Nrf2 activators that can disrupt Nrf2-Keap1 interaction by using a virtual screening approach and identified a potent Nrf2 activator, KKPA4026.	3,7-dihydro-1,8-dimethyl-3-phenyl-1H-purine-2,6-dione	167-175	kelch-like ECH-associated protein 1	Mus musculus	71-76
32032607-9	2020	In summary, we identified KKPA4026 as a novel Nrf2 activator and suggested that Nrf2 activation through interference with the Nrf2-Keap1 interaction may be effective for PD treatment.	3,7-dihydro-1,8-dimethyl-3-phenyl-1H-purine-2,6-dione	26-34	kelch-like ECH-associated protein 1	Mus musculus	131-136
32405635-0	2020	Astaxanthin from Haematococcus pluvialis ameliorates the chemotherapeutic drug (doxorubicin) induced liver injury through the Keap1/Nrf2/HO-1 pathway in mice.	astaxanthine	0-11	kelch-like ECH-associated protein 1	Mus musculus	126-131
32405635-0	2020	Astaxanthin from Haematococcus pluvialis ameliorates the chemotherapeutic drug (doxorubicin) induced liver injury through the Keap1/Nrf2/HO-1 pathway in mice.	Doxorubicin	80-91	kelch-like ECH-associated protein 1	Mus musculus	126-131
31874170-0	2020	A novel biscoumarin compound ameliorates cerebral ischemia reperfusion-induced mitochondrial oxidative injury via Nrf2/Keap-1/ARE signaling.	6,6',7,7'-tetramethoxyl-8,8'-biscoumarin	8-19	kelch-like ECH-associated protein 1	Mus musculus	119-125
32073640-7	2020	In both KCs and T cells, DCAC treatment significantly downregulated Nrf2 and HO-1 expression along with induction of Keap-1, NF-kappaB (p65), TNF-alpha and iNOS, whereas pre-treatment of these cells with tBHQ attenuated these responses.	Chlorides	25-29	kelch-like ECH-associated protein 1	Mus musculus	117-123
31552548-8	2020	Furthermore, Ori inhibited NOX-4 levels, initiated the dissociation of KEAP-1 from Nrf2, activated the downstream genes HO-1 and exerted antioxidative effects on CAR-induced pleurisy.	oridonin	13-16	kelch-like ECH-associated protein 1	Mus musculus	71-77
31645661-6	2020	Simultaneously, AB38b or resveratrol markedly lowered the level of Keap1, accompanied by evident activation of Nrf2 signaling in the diabetic kidney.	resveratrol	25-36	kelch-like ECH-associated protein 1	Mus musculus	67-72
32070920-0	2020	S-allylmercaptocysteine ameliorates lipopolysaccharide-induced acute lung injury in mice by inhibiting inflammation and oxidative stress via nuclear factor kappa B and Keap1/Nrf2 pathways.	S-allylmercaptocysteine	0-23	kelch-like ECH-associated protein 1	Mus musculus	168-173
32070920-7	2020	Meanwhile, SAMC up-regulated expressions of endogenous antioxidant/detoxifying proteins including heme oxygenase-1 (HO-1) and NAD(P)H: quinone oxidoreductase 1(NQO1) through reversing the suppression of Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid-2 related factor 2 (Nrf2) signaling pathway.	S-allylmercaptocysteine	11-15	kelch-like ECH-associated protein 1	Mus musculus	203-238
32070920-7	2020	Meanwhile, SAMC up-regulated expressions of endogenous antioxidant/detoxifying proteins including heme oxygenase-1 (HO-1) and NAD(P)H: quinone oxidoreductase 1(NQO1) through reversing the suppression of Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid-2 related factor 2 (Nrf2) signaling pathway.	S-allylmercaptocysteine	11-15	kelch-like ECH-associated protein 1	Mus musculus	240-245
32070920-8	2020	Our results demonstrate that SAMC effectively attenuated LPS-induced ALI which was largely dependent upon inhibition of inflammation and oxidative stress via NF-kappaB and Keap1/Nrf2 signaling pathways.	S-allylmercaptocysteine	29-33	kelch-like ECH-associated protein 1	Mus musculus	172-177
32031966-6	2020	In aortic endothelial cells (ECs) isolated from C57BL/6 wild-type (WT) mice, high glucose (HG) reduced miR-200a level and increased the expression of kelch-like ECH-associated protein 1 (Keap1) - a target of miR-200a and a negative regulator of NRF2.	Glucose	82-89	kelch-like ECH-associated protein 1	Mus musculus	150-185
32031966-6	2020	In aortic endothelial cells (ECs) isolated from C57BL/6 wild-type (WT) mice, high glucose (HG) reduced miR-200a level and increased the expression of kelch-like ECH-associated protein 1 (Keap1) - a target of miR-200a and a negative regulator of NRF2.	Glucose	82-89	kelch-like ECH-associated protein 1	Mus musculus	187-192
32197464-0	2020	Protective Effect of Astaxanthin on Ochratoxin A-Induced Kidney Injury to Mice by Regulating Oxidative Stress-Related NRF2/KEAP1 Pathway.	astaxanthine	21-32	kelch-like ECH-associated protein 1	Mus musculus	123-128
32197464-0	2020	Protective Effect of Astaxanthin on Ochratoxin A-Induced Kidney Injury to Mice by Regulating Oxidative Stress-Related NRF2/KEAP1 Pathway.	ochratoxin A	36-48	kelch-like ECH-associated protein 1	Mus musculus	123-128
32190177-10	2020	ASX played a protective role by changing the expression of Keap1, Nrf2, HO-1, Bax, Bcl-2, Caspase3, and Caspase9 proteins.	astaxanthine	0-3	kelch-like ECH-associated protein 1	Mus musculus	59-64
32190177-11	2020	These results indicate that the protective mechanism of ASX on the myocardium works through the Keap1-Nrf2 signaling pathway and mitochondria-mediated apoptosis pathway.	astaxanthine	56-59	kelch-like ECH-associated protein 1	Mus musculus	96-101
31645661-9	2020	Furthermore, AB38b or resveratrol treatment effectively activated Nrf2 signaling by inhibiting Keap1 expression without affecting the interaction between Keap1 and Nrf2.	resveratrol	22-33	kelch-like ECH-associated protein 1	Mus musculus	95-100
31972171-0	2020	Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.	Curcumin	0-8	kelch-like ECH-associated protein 1	Mus musculus	55-60
31972171-0	2020	Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.	Cysteine	61-69	kelch-like ECH-associated protein 1	Mus musculus	55-60
31972171-6	2020	Cells transfected with a mutant Keap1 protein in which cysteine 151 is replaced by serine exhibited marked reduction in curcumin-induced Nrf2 transactivation.	Curcumin	120-128	kelch-like ECH-associated protein 1	Mus musculus	32-37
31972171-7	2020	Mass spectrometric analysis revealed that curcumin binds to Keap1 Cys151, supporting that this amino acid is a critical target for curcumin modification of Keap1, which facilitates the liberation of Nrf2.	Curcumin	42-50	kelch-like ECH-associated protein 1	Mus musculus	60-65
31972171-7	2020	Mass spectrometric analysis revealed that curcumin binds to Keap1 Cys151, supporting that this amino acid is a critical target for curcumin modification of Keap1, which facilitates the liberation of Nrf2.	Curcumin	42-50	kelch-like ECH-associated protein 1	Mus musculus	156-161
31972171-7	2020	Mass spectrometric analysis revealed that curcumin binds to Keap1 Cys151, supporting that this amino acid is a critical target for curcumin modification of Keap1, which facilitates the liberation of Nrf2.	Curcumin	131-139	kelch-like ECH-associated protein 1	Mus musculus	60-65
31972171-7	2020	Mass spectrometric analysis revealed that curcumin binds to Keap1 Cys151, supporting that this amino acid is a critical target for curcumin modification of Keap1, which facilitates the liberation of Nrf2.	Curcumin	131-139	kelch-like ECH-associated protein 1	Mus musculus	156-161
31972171-8	2020	Thus, it is likely that the alpha,beta-unsaturated carbonyl moiety of curcumin is critical essential for its binding to Keap1 and stabilization of Nrf2 by hampering ubiquitination and proteasomal degradation.	Fats, Unsaturated	28-59	kelch-like ECH-associated protein 1	Mus musculus	120-125
31972171-8	2020	Thus, it is likely that the alpha,beta-unsaturated carbonyl moiety of curcumin is critical essential for its binding to Keap1 and stabilization of Nrf2 by hampering ubiquitination and proteasomal degradation.	Curcumin	70-78	kelch-like ECH-associated protein 1	Mus musculus	120-125
31828396-14	2020	(p-ClPhSe)2 modulated the cerebral cortical Keap1/Nrf2/HO-1 pathway in diabetic mice.	(p-clphse)2	0-11	kelch-like ECH-associated protein 1	Mus musculus	44-49
31932477-4	2020	Matrix-assisted laser desorption ionization-mass spectrometry imaging revealed that reduced glutathione levels were elevated by Nrf2 induction in AppNLGF ::Keap1FA/FA mouse brains compared to AppNLGF mouse brains.	Glutathione	92-103	kelch-like ECH-associated protein 1	Mus musculus	156-163
32010316-0	2020	Edaravone attenuates experimental asthma in mice through induction of HO-1 and the Keap1/Nrf2 pathway.	edaravone	0-9	kelch-like ECH-associated protein 1	Mus musculus	83-88
32010316-12	2020	The Keap1/Nrf2 ratio was significantly decreased with Eda compared with control due to an increase in Nrf2 and a decrease in Keap1 expression.	edaravone	54-57	kelch-like ECH-associated protein 1	Mus musculus	4-9
32010316-12	2020	The Keap1/Nrf2 ratio was significantly decreased with Eda compared with control due to an increase in Nrf2 and a decrease in Keap1 expression.	edaravone	54-57	kelch-like ECH-associated protein 1	Mus musculus	125-130
32010316-16	2020	The activated Keap1/Nrf2 pathway and HO-1 may be involved in the anti-asthmatic effect of Eda.	edaravone	90-93	kelch-like ECH-associated protein 1	Mus musculus	14-19
32141447-0	2020	Isoliquiritigenin exerts antioxidative and anti-inflammatory effects via activating the KEAP-1/Nrf2 pathway and inhibiting the NF-kappaB and NLRP3 pathways in carrageenan-induced pleurisy.	isoliquiritigenin	0-17	kelch-like ECH-associated protein 1	Mus musculus	88-94
32079324-2	2020	Nrf2 governs the gene expression of endogenous antioxidant synthesis and ROS-eliminating enzymes in response to various electrophilic compounds that inactivate the negative regulator Keap1.	Reactive Oxygen Species	73-76	kelch-like ECH-associated protein 1	Mus musculus	183-188
31729764-0	2020	Sinomenine attenuates septic-associated lung injury through the Nrf2-Keap1 and autophagy.	sinomenine	0-10	kelch-like ECH-associated protein 1	Mus musculus	69-74
31828396-0	2020	Keap1/Nrf2/HO-1 signaling pathway contributes to p-chlorodiphenyl diselenide antidepressant-like action in diabetic mice.	p-chloro-diphenyl diselenide	49-76	kelch-like ECH-associated protein 1	Mus musculus	0-5
31828396-15	2020	CONCLUSIONS: This study demonstrates the contribution of cerebral cortical Keap1/Nrf2/HO-1 pathway in the (p-ClPhSe)2 antidepressant-like action in diabetic mice.	(p-clphse)2	106-117	kelch-like ECH-associated protein 1	Mus musculus	75-80
31738935-0	2020	Ginsenoside Rg1 protects mice against streptozotocin-induced type 1 diabetic by modulating the NLRP3 and Keap1/Nrf2/HO-1 pathways.	Streptozocin	38-52	kelch-like ECH-associated protein 1	Mus musculus	105-110
32090078-0	2020	Pentamethylquercetin Attenuates Cardiac Remodeling via Activation of the Sestrins/Keap1/Nrf2 Pathway in MSG-Induced Obese Mice.	Quercetin pentamethyl ether	0-20	kelch-like ECH-associated protein 1	Mus musculus	82-87
32090078-10	2020	Further study revealed that the protective effects of PMQ might be mediated by promoting Keap1 degradation and augmenting sestrins expression and Nrf2 nuclear translocation.	pmq	54-57	kelch-like ECH-associated protein 1	Mus musculus	89-94
32090078-11	2020	Conclusion: Our findings indicated that PMQ ameliorated cardiac remodeling in obese mice by targeting the sestrins/Keap1/Nrf2 signaling pathway.	pmq	40-43	kelch-like ECH-associated protein 1	Mus musculus	115-120
31705858-7	2020	Our initial findings in GO mice were that PD attenuated orbital muscle adipose tissue expansion and lipid droplet accumulation through a nuclear factor E2-related factor 2 (NRF2)-mediated oxidative stress response involving the Keap1/Nrf2/ARE pathway.	polydatin	42-44	kelch-like ECH-associated protein 1	Mus musculus	228-233
31629711-10	2020	17-Oxo-DHA also markedly reduced the level of Keap1 protein by inducing ubiquitination.	Docosahexaenoic Acids	0-10	kelch-like ECH-associated protein 1	Mus musculus	46-51
31629711-11	2020	Mutation of Cys151 and Cys273 in Keap1 abrogated 17-oxo-DHA-induced ubiquitination and proteasome-mediated degradation of Keap1 as well as HO-1 expression, suggesting that these cysteine residues are putative sites for 17-oxo-DHA binding.	cysteinylcysteine	12-15	kelch-like ECH-associated protein 1	Mus musculus	33-38
31629711-11	2020	Mutation of Cys151 and Cys273 in Keap1 abrogated 17-oxo-DHA-induced ubiquitination and proteasome-mediated degradation of Keap1 as well as HO-1 expression, suggesting that these cysteine residues are putative sites for 17-oxo-DHA binding.	cysteinylcysteine	12-15	kelch-like ECH-associated protein 1	Mus musculus	122-127
31629711-11	2020	Mutation of Cys151 and Cys273 in Keap1 abrogated 17-oxo-DHA-induced ubiquitination and proteasome-mediated degradation of Keap1 as well as HO-1 expression, suggesting that these cysteine residues are putative sites for 17-oxo-DHA binding.	cysteinylcysteine	23-26	kelch-like ECH-associated protein 1	Mus musculus	33-38
31629711-11	2020	Mutation of Cys151 and Cys273 in Keap1 abrogated 17-oxo-DHA-induced ubiquitination and proteasome-mediated degradation of Keap1 as well as HO-1 expression, suggesting that these cysteine residues are putative sites for 17-oxo-DHA binding.	cysteinylcysteine	23-26	kelch-like ECH-associated protein 1	Mus musculus	122-127
31629711-11	2020	Mutation of Cys151 and Cys273 in Keap1 abrogated 17-oxo-DHA-induced ubiquitination and proteasome-mediated degradation of Keap1 as well as HO-1 expression, suggesting that these cysteine residues are putative sites for 17-oxo-DHA binding.	Docosahexaenoic Acids	56-59	kelch-like ECH-associated protein 1	Mus musculus	33-38
31629711-11	2020	Mutation of Cys151 and Cys273 in Keap1 abrogated 17-oxo-DHA-induced ubiquitination and proteasome-mediated degradation of Keap1 as well as HO-1 expression, suggesting that these cysteine residues are putative sites for 17-oxo-DHA binding.	Docosahexaenoic Acids	56-59	kelch-like ECH-associated protein 1	Mus musculus	122-127
31629711-11	2020	Mutation of Cys151 and Cys273 in Keap1 abrogated 17-oxo-DHA-induced ubiquitination and proteasome-mediated degradation of Keap1 as well as HO-1 expression, suggesting that these cysteine residues are putative sites for 17-oxo-DHA binding.	Cysteine	178-186	kelch-like ECH-associated protein 1	Mus musculus	33-38
31629711-11	2020	Mutation of Cys151 and Cys273 in Keap1 abrogated 17-oxo-DHA-induced ubiquitination and proteasome-mediated degradation of Keap1 as well as HO-1 expression, suggesting that these cysteine residues are putative sites for 17-oxo-DHA binding.	Docosahexaenoic Acids	226-229	kelch-like ECH-associated protein 1	Mus musculus	33-38
31629711-12	2020	Further, Keap1 degradation stimulated by 17-oxo-DHA coincided with accumulation of the autophage substrate, p62/SQSTM1.	Docosahexaenoic Acids	48-51	kelch-like ECH-associated protein 1	Mus musculus	9-14
31647720-8	2020	Exercise increased the cardiac expression of the NRF2/KEAP1 ratio and phase II antioxidants in fructose-fed mice (P&lt;0.05).	Fructose	95-103	kelch-like ECH-associated protein 1	Mus musculus	54-59
30907226-4	2020	The NFE2L2/NRF2 (nuclear factor, erythroid 2 like 2)-KEAP1 (kelch like ECH associated protein 1) pathway is essential for the elimination of ROS.	Reactive Oxygen Species	141-144	kelch-like ECH-associated protein 1	Mus musculus	53-58
30907226-4	2020	The NFE2L2/NRF2 (nuclear factor, erythroid 2 like 2)-KEAP1 (kelch like ECH associated protein 1) pathway is essential for the elimination of ROS.	Reactive Oxygen Species	141-144	kelch-like ECH-associated protein 1	Mus musculus	60-95
31536771-4	2020	We probed the reactivity of the bioactivation product of cymopol, cymopol quinone, which was able to modify various cysteine residues of Nrf2"s cytoplasmic repressor protein Keap1.	Cymopol	57-64	kelch-like ECH-associated protein 1	Mus musculus	174-179
31536771-4	2020	We probed the reactivity of the bioactivation product of cymopol, cymopol quinone, which was able to modify various cysteine residues of Nrf2"s cytoplasmic repressor protein Keap1.	cymopol quinone	66-81	kelch-like ECH-associated protein 1	Mus musculus	174-179
31536771-4	2020	We probed the reactivity of the bioactivation product of cymopol, cymopol quinone, which was able to modify various cysteine residues of Nrf2"s cytoplasmic repressor protein Keap1.	Cysteine	116-124	kelch-like ECH-associated protein 1	Mus musculus	174-179
31590160-0	2019	Probucol, a "non-statin" cholesterol-lowering drug, ameliorates D-galactose induced cognitive deficits by alleviating oxidative stress via Keap1/Nrf2 signaling pathway in mice.	Probucol	0-8	kelch-like ECH-associated protein 1	Mus musculus	139-144
31849693-6	2019	Moreover, farrerol effectively activated Nrf2 and subsequently increased the expression of Nrf2-targeted antioxidant enzymes, including heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase-1 (NQO1), but inhibited Kelch-like ECH-associated protein 1 (Keap1) and NADPH oxidase type 4 (NOX4).	farrerol	10-18	kelch-like ECH-associated protein 1	Mus musculus	219-254
31849693-6	2019	Moreover, farrerol effectively activated Nrf2 and subsequently increased the expression of Nrf2-targeted antioxidant enzymes, including heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase-1 (NQO1), but inhibited Kelch-like ECH-associated protein 1 (Keap1) and NADPH oxidase type 4 (NOX4).	farrerol	10-18	kelch-like ECH-associated protein 1	Mus musculus	256-261
31827675-9	2019	The maggot extracts increased the level of Nrf2 and prevented the degradation of Nrf2 through downregulating the expression of Keap1, which resulted in augmented levels of HO-1, SOD, and GSH-Px and reduced levels of MPO and MDA.	Glutathione	187-190	kelch-like ECH-associated protein 1	Mus musculus	127-132
31827675-9	2019	The maggot extracts increased the level of Nrf2 and prevented the degradation of Nrf2 through downregulating the expression of Keap1, which resulted in augmented levels of HO-1, SOD, and GSH-Px and reduced levels of MPO and MDA.	Malondialdehyde	224-227	kelch-like ECH-associated protein 1	Mus musculus	127-132
31349040-0	2019	S-1-propenylmercaptocysteine protects murine hepatocytes against oxidative stress via persulfidation of Keap1 and activation of Nrf2.	s-1-propenylmercaptocysteine	0-28	kelch-like ECH-associated protein 1	Mus musculus	104-109
31590160-7	2019	Furthermore, Prob promoted the dissociation of Keap1/Nrf2 complex leading to the accumulation of Nrf2 in nucleus, implying that the improved anti-oxidant property of Prob is mediated by Keap1/Nrf2 pathway.	Probucol	13-17	kelch-like ECH-associated protein 1	Mus musculus	47-52
31590160-7	2019	Furthermore, Prob promoted the dissociation of Keap1/Nrf2 complex leading to the accumulation of Nrf2 in nucleus, implying that the improved anti-oxidant property of Prob is mediated by Keap1/Nrf2 pathway.	Probucol	13-17	kelch-like ECH-associated protein 1	Mus musculus	186-191
31590160-7	2019	Furthermore, Prob promoted the dissociation of Keap1/Nrf2 complex leading to the accumulation of Nrf2 in nucleus, implying that the improved anti-oxidant property of Prob is mediated by Keap1/Nrf2 pathway.	Probucol	166-170	kelch-like ECH-associated protein 1	Mus musculus	47-52
31270710-0	2019	Neuroprotective Effect of Natural Alkaloid Fangchinoline Against Oxidative Glutamate Toxicity: Involvement of Keap1-Nrf2 Axis Regulation.	fangchinoline	43-56	kelch-like ECH-associated protein 1	Mus musculus	110-115
31349040-12	2019	Taken together, our results showed that attenuation of oxidative stress by CySSPe is associated with its ability to produce H2S or RSSH, which persulfidates Keap1 and activates Nrf2 signaling.	Hydrogen Sulfide	124-127	kelch-like ECH-associated protein 1	Mus musculus	157-162
31349040-12	2019	Taken together, our results showed that attenuation of oxidative stress by CySSPe is associated with its ability to produce H2S or RSSH, which persulfidates Keap1 and activates Nrf2 signaling.	rssh	131-135	kelch-like ECH-associated protein 1	Mus musculus	157-162
31590160-7	2019	Furthermore, Prob promoted the dissociation of Keap1/Nrf2 complex leading to the accumulation of Nrf2 in nucleus, implying that the improved anti-oxidant property of Prob is mediated by Keap1/Nrf2 pathway.	Probucol	166-170	kelch-like ECH-associated protein 1	Mus musculus	186-191
31016762-7	2019	Overall, eriodictyol protects LPS-triggered oxidative stress, neuroinflammation, and synaptic dysfunctions partially through MAPKs, NF-kappaB mediated by ROS, Sirt1, and Nrf2/Keap1 signal pathways, which further supports that eriodictyol is a potentially nutritional preventive strategy for oxidative stress-related neurodegenerative diseases.	eriodictyol	9-20	kelch-like ECH-associated protein 1	Mus musculus	175-180
31155513-0	2019	Enhanced Keap1-Nrf2 signaling protects the myocardium from isoproterenol-induced pathological remodeling in mice.	Isoproterenol	59-72	kelch-like ECH-associated protein 1	Mus musculus	9-14
31572984-7	2019	The Nrf2 activity of the compound NQC was determined using "Keap1:Nrf2 Inhibitor Screening Assay Kit".	Nitrogen	34-37	kelch-like ECH-associated protein 1	Mus musculus	60-65
31572984-13	2019	Molecular docking studies confirmed the favourable binding of NQC at Kelch domain of Keap-1.	Nitrogen	62-65	kelch-like ECH-associated protein 1	Mus musculus	85-91
31572199-8	2019	Mechanism study showed that dioscin remarkably up-regulated the expression levels of silent information regulator 1 (Sirt1) and heme oxygenase-1 (HO-1) via increase of the nuclear translocation of NF-E2-related factor 2 (Nrf2) and suppressed the expression levels of forkhead box protein O1 (FOXO1) and kelch-like ECH-associated protein-1 (Keap1) to inhibit oxidative stress.	dioscin	28-35	kelch-like ECH-associated protein 1	Mus musculus	303-338
31572199-8	2019	Mechanism study showed that dioscin remarkably up-regulated the expression levels of silent information regulator 1 (Sirt1) and heme oxygenase-1 (HO-1) via increase of the nuclear translocation of NF-E2-related factor 2 (Nrf2) and suppressed the expression levels of forkhead box protein O1 (FOXO1) and kelch-like ECH-associated protein-1 (Keap1) to inhibit oxidative stress.	dioscin	28-35	kelch-like ECH-associated protein 1	Mus musculus	340-345
31016762-5	2019	Besides, eriodictyol alleviated LPS-induced oxidative stress via NF-E2-Related factor2/Kelch-like ECH-associated protein 1 (Nrf2/Keap1) pathway in vivo and in vitro.	eriodictyol	9-20	kelch-like ECH-associated protein 1	Mus musculus	129-134
30211983-7	2019	In activated neutrophils, taurine reacts with hypochloric acid to form taurine chloramine, which triggers the Kelch-like ECH-associated protein 1-nuclear factor E2-related factor 1 (Keap1-Nrf2) pathway.	Taurine	26-33	kelch-like ECH-associated protein 1	Mus musculus	182-187
30211983-7	2019	In activated neutrophils, taurine reacts with hypochloric acid to form taurine chloramine, which triggers the Kelch-like ECH-associated protein 1-nuclear factor E2-related factor 1 (Keap1-Nrf2) pathway.	Hypochlorous Acid	46-62	kelch-like ECH-associated protein 1	Mus musculus	182-187
31636565-6	2019	An increase in the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1) ratio were also found in both the parietal cortex and hippocampus following neonatal exposure to THC.	Dronabinol	211-214	kelch-like ECH-associated protein 1	Mus musculus	70-105
31636565-6	2019	An increase in the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1) ratio were also found in both the parietal cortex and hippocampus following neonatal exposure to THC.	Dronabinol	211-214	kelch-like ECH-associated protein 1	Mus musculus	107-112
31547327-5	2019	Moreover, EC was found to inhibit the Kelch-like ECH-associated protein 1 (Keap1) protein, and to enhance the nuclear transcription factor erythroid 2-related factor (Nrf2) and the expression of the heme oxygenase-1 (HO-1) protein.	erinacine C	10-12	kelch-like ECH-associated protein 1	Mus musculus	38-73
31547327-5	2019	Moreover, EC was found to inhibit the Kelch-like ECH-associated protein 1 (Keap1) protein, and to enhance the nuclear transcription factor erythroid 2-related factor (Nrf2) and the expression of the heme oxygenase-1 (HO-1) protein.	erinacine C	10-12	kelch-like ECH-associated protein 1	Mus musculus	75-80
31279986-0	2019	CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-kappaB activation.	CPUY013 compound	0-10	kelch-like ECH-associated protein 1	Mus musculus	38-43
31251921-7	2019	The induction of HO-1 by quercetin was associated with the nuclear accumulation of Nrf2 and downregulation of Keap1, a negative regulator of Nrf2.	Quercetin	25-34	kelch-like ECH-associated protein 1	Mus musculus	110-115
30211983-7	2019	In activated neutrophils, taurine reacts with hypochloric acid to form taurine chloramine, which triggers the Kelch-like ECH-associated protein 1-nuclear factor E2-related factor 1 (Keap1-Nrf2) pathway.	N-chlorotaurine	71-89	kelch-like ECH-associated protein 1	Mus musculus	182-187
31112750-6	2019	Mechanism investigation showed that Dox markedly up-regulated the expression level of miR-128-3p, down-regulated Sirt1 expression level and affected the protein levels of Nrf2, Keap1, Sirt3, NQO1 and HO-1 to cause oxidative stress in liver.	Doxorubicin	36-39	kelch-like ECH-associated protein 1	Mus musculus	177-182
31396303-7	2019	ME treatment relieved the alcohol-induced imbalance in prooxidative and antioxidative signaling via nuclear factor-erythroid 2-related factor 2 (Nrf-2), as indicated by upregulation of superoxide dismutase-1, superoxide dismutase-2, catalase, heme oxygenase-1, and heme oxygenase-2 expression and downregulation of kelch-like ECH-associated protein 1 (Keap-1) in the liver.	Alcohols	26-33	kelch-like ECH-associated protein 1	Mus musculus	315-350
31315052-1	2019	The Keap1-Nrf2 system plays a central role in the oxidative stress response; however, the identity of the reactive oxygen species sensor within Keap1 remains poorly understood.	oxygen species	115-129	kelch-like ECH-associated protein 1	Mus musculus	4-9
31315052-1	2019	The Keap1-Nrf2 system plays a central role in the oxidative stress response; however, the identity of the reactive oxygen species sensor within Keap1 remains poorly understood.	oxygen species	115-129	kelch-like ECH-associated protein 1	Mus musculus	144-149
31315052-2	2019	Here, we show that a Keap1 mutant lacking 11 cysteine residues retains the ability to target Nrf2 for degradation, but it is unable to respond to cysteine-reactive Nrf2 inducers.	Cysteine	45-53	kelch-like ECH-associated protein 1	Mus musculus	21-26
31315052-2	2019	Here, we show that a Keap1 mutant lacking 11 cysteine residues retains the ability to target Nrf2 for degradation, but it is unable to respond to cysteine-reactive Nrf2 inducers.	Cysteine	146-154	kelch-like ECH-associated protein 1	Mus musculus	21-26
31315052-4	2019	Our analyses of multiple mutant mice lines, complemented by MEFs expressing a series of Keap1 mutants, reveal that Keap1 uses the cysteine residues redundantly to set up an elaborate fail-safe mechanism in which specific combinations of these four cysteine residues can form a disulfide bond to sense hydrogen peroxide.	Cysteine	130-138	kelch-like ECH-associated protein 1	Mus musculus	115-120
31396303-7	2019	ME treatment relieved the alcohol-induced imbalance in prooxidative and antioxidative signaling via nuclear factor-erythroid 2-related factor 2 (Nrf-2), as indicated by upregulation of superoxide dismutase-1, superoxide dismutase-2, catalase, heme oxygenase-1, and heme oxygenase-2 expression and downregulation of kelch-like ECH-associated protein 1 (Keap-1) in the liver.	Alcohols	26-33	kelch-like ECH-associated protein 1	Mus musculus	352-358
31315052-4	2019	Our analyses of multiple mutant mice lines, complemented by MEFs expressing a series of Keap1 mutants, reveal that Keap1 uses the cysteine residues redundantly to set up an elaborate fail-safe mechanism in which specific combinations of these four cysteine residues can form a disulfide bond to sense hydrogen peroxide.	Cysteine	248-256	kelch-like ECH-associated protein 1	Mus musculus	88-93
31315052-4	2019	Our analyses of multiple mutant mice lines, complemented by MEFs expressing a series of Keap1 mutants, reveal that Keap1 uses the cysteine residues redundantly to set up an elaborate fail-safe mechanism in which specific combinations of these four cysteine residues can form a disulfide bond to sense hydrogen peroxide.	Cysteine	248-256	kelch-like ECH-associated protein 1	Mus musculus	115-120
31156435-10	2019	Further experiments show that miR-873-5p could regulate Keap1-Nrf2 pathway against colistin-induced oxidative stress and apoptosis.	mir-873-5p	30-40	kelch-like ECH-associated protein 1	Mus musculus	56-61
31315052-4	2019	Our analyses of multiple mutant mice lines, complemented by MEFs expressing a series of Keap1 mutants, reveal that Keap1 uses the cysteine residues redundantly to set up an elaborate fail-safe mechanism in which specific combinations of these four cysteine residues can form a disulfide bond to sense hydrogen peroxide.	Disulfides	277-286	kelch-like ECH-associated protein 1	Mus musculus	115-120
31315052-4	2019	Our analyses of multiple mutant mice lines, complemented by MEFs expressing a series of Keap1 mutants, reveal that Keap1 uses the cysteine residues redundantly to set up an elaborate fail-safe mechanism in which specific combinations of these four cysteine residues can form a disulfide bond to sense hydrogen peroxide.	Hydrogen Peroxide	301-318	kelch-like ECH-associated protein 1	Mus musculus	115-120
31315052-5	2019	This sensing mechanism is distinct from that used for electrophilic Nrf2 inducers, demonstrating that Keap1 is equipped with multiple cysteine-based sensors to detect various endogenous and exogenous stresses.	Cysteine	134-142	kelch-like ECH-associated protein 1	Mus musculus	102-107
31059771-4	2019	In this study, we investigated the effect of Nrf2 activation on ECM production and TGF-beta/Smad signaling using Keap1-silenced MES-13 cells (a genetic glomerular mesangial cell model with Nrf2 overexpression).	2-(N-morpholino)ethanesulfonic acid	128-131	kelch-like ECH-associated protein 1	Mus musculus	113-118
31017694-0	2019	MicroRNA-1225 activates Keap1-Nrf2-HO-1 signalling to inhibit TNFalpha-induced osteoclastogenesis by mediating ROS generation.	Reactive Oxygen Species	111-114	kelch-like ECH-associated protein 1	Mus musculus	24-29
31017694-7	2019	Furthermore, reactive oxygen species (ROS) generation that is related to osteoclastogenesis and the Keap-Nrf2 axis was impaired by the miR-1225 mimic and Keap1 silencing, whereas it was increased following miR inhibition and overexpression of Keap1 and TNFalpha.	Reactive Oxygen Species	13-36	kelch-like ECH-associated protein 1	Mus musculus	154-159
31017694-7	2019	Furthermore, reactive oxygen species (ROS) generation that is related to osteoclastogenesis and the Keap-Nrf2 axis was impaired by the miR-1225 mimic and Keap1 silencing, whereas it was increased following miR inhibition and overexpression of Keap1 and TNFalpha.	Reactive Oxygen Species	13-36	kelch-like ECH-associated protein 1	Mus musculus	243-248
31017694-7	2019	Furthermore, reactive oxygen species (ROS) generation that is related to osteoclastogenesis and the Keap-Nrf2 axis was impaired by the miR-1225 mimic and Keap1 silencing, whereas it was increased following miR inhibition and overexpression of Keap1 and TNFalpha.	Reactive Oxygen Species	38-41	kelch-like ECH-associated protein 1	Mus musculus	154-159
31017694-7	2019	Furthermore, reactive oxygen species (ROS) generation that is related to osteoclastogenesis and the Keap-Nrf2 axis was impaired by the miR-1225 mimic and Keap1 silencing, whereas it was increased following miR inhibition and overexpression of Keap1 and TNFalpha.	Reactive Oxygen Species	38-41	kelch-like ECH-associated protein 1	Mus musculus	243-248
31017694-8	2019	Thus, miR-1225 inhibits osteoclastogenesis by directly activating the Keap1-Nrf2-HO-1 axis to repress TNFalpha-mediated ROS generation.	Reactive Oxygen Species	120-123	kelch-like ECH-associated protein 1	Mus musculus	70-75
30840341-0	2019	Rapamycin Induced Autophagy Inhibits Inflammation-Mediated Endplate Degeneration by Enhancing Nrf2/Keap1 Signaling of Cartilage Endplate Stem Cells.	Sirolimus	0-9	kelch-like ECH-associated protein 1	Mus musculus	99-104
30840341-7	2019	Taken together, the results indicate that rapamycin-induced autophagy enhances Nrf2/Keap1 signaling and promotes the expression of antioxidant proteins, thereby eliminating ROS, alleviating cell senescence, reducing the osteogenic differentiation of CESCs, and ultimately protecting CEPs from chronic inflammation-induced degeneration.	Sirolimus	42-51	kelch-like ECH-associated protein 1	Mus musculus	84-89
31112588-0	2019	Curcumin attenuates oxidative stress in RAW264.7 cells by increasing the activity of antioxidant enzymes and activating the Nrf2-Keap1 pathway.	Curcumin	0-8	kelch-like ECH-associated protein 1	Mus musculus	129-134
31112588-8	2019	The effect of curcumin on Nrf2-Keap1 signaling pathway-related genes was analyzed by qRT-PCR.	Curcumin	14-22	kelch-like ECH-associated protein 1	Mus musculus	31-36
31112588-16	2019	Curcumin resisted oxidants by increasing the activity of antioxidant enzymes and activating the Nrf2-Keap1 pathway, which could potentially promote cell survival.	Curcumin	0-8	kelch-like ECH-associated protein 1	Mus musculus	101-106
31214283-0	2019	Salvianolic Acid C against Acetaminophen-Induced Acute Liver Injury by Attenuating Inflammation, Oxidative Stress, and Apoptosis through Inhibition of the Keap1/Nrf2/HO-1 Signaling.	salvianolic acid C	0-18	kelch-like ECH-associated protein 1	Mus musculus	155-160
31214283-0	2019	Salvianolic Acid C against Acetaminophen-Induced Acute Liver Injury by Attenuating Inflammation, Oxidative Stress, and Apoptosis through Inhibition of the Keap1/Nrf2/HO-1 Signaling.	Acetaminophen	27-40	kelch-like ECH-associated protein 1	Mus musculus	155-160
31060323-9	2019	Further experiments demonstrated that TRIOL can activate and upregulate Nrf2, along with its downstream hemeoxygenase-1 (HO-1), by negative regulation of Kelch-like ECH (Enoyl-CoA Hydratase) associated Protein-1 (Keap1).	triol	38-43	kelch-like ECH-associated protein 1	Mus musculus	213-218
30836114-0	2019	MitoQ ameliorates testis injury from oxidative attack by repairing mitochondria and promoting the Keap1-Nrf2 pathway.	mitoquinone	0-5	kelch-like ECH-associated protein 1	Mus musculus	98-103
30836114-7	2019	Further mechanism studies revealed that MitoQ markedly activates the Keap1-Nrf2 antioxidative defense system characterized by increasing the expression of Nrf2 and its target genes HO-1 and NQO1.	mitoquinone	40-45	kelch-like ECH-associated protein 1	Mus musculus	69-74
31214283-9	2019	Taken together, we provide the molecular evidence that SAC protected the hepatocytes from APAP-induced damage by mitigating mitochondrial oxidative stress, inflammatory response, and caspase-mediated antiapoptotic effect through inhibition of the Keap1/Nrf2/HO-1 signaling axis.	Acetaminophen	90-94	kelch-like ECH-associated protein 1	Mus musculus	247-252
30995469-1	2019	Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) proteins work in concert to regulate the levels of reactive oxygen species (ROS).	Reactive Oxygen Species	150-173	kelch-like ECH-associated protein 1	Mus musculus	0-35
30995469-1	2019	Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) proteins work in concert to regulate the levels of reactive oxygen species (ROS).	Reactive Oxygen Species	150-173	kelch-like ECH-associated protein 1	Mus musculus	37-42
30995469-1	2019	Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) proteins work in concert to regulate the levels of reactive oxygen species (ROS).	Reactive Oxygen Species	175-178	kelch-like ECH-associated protein 1	Mus musculus	0-35
30995469-1	2019	Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) proteins work in concert to regulate the levels of reactive oxygen species (ROS).	Reactive Oxygen Species	175-178	kelch-like ECH-associated protein 1	Mus musculus	37-42
30995469-5	2019	Keap1-deficient NKT cells show increased rates of proliferation and apoptosis, as well as increased glucose uptake and mitochondrial function, but reduced ROS, CD122, and Bcl2 expression.	Glucose	100-107	kelch-like ECH-associated protein 1	Mus musculus	0-5
30995469-5	2019	Keap1-deficient NKT cells show increased rates of proliferation and apoptosis, as well as increased glucose uptake and mitochondrial function, but reduced ROS, CD122, and Bcl2 expression.	Reactive Oxygen Species	155-158	kelch-like ECH-associated protein 1	Mus musculus	0-5
30760288-0	2019	Activation of Nrf2/Keap1 pathway by oral Dimethylfumarate administration alleviates oxidative stress and age-associated infertility might be delayed in the mouse ovary.	Dimethyl Fumarate	41-57	kelch-like ECH-associated protein 1	Mus musculus	19-24
30734183-7	2019	In vivo experiments also showed that high-dose PQ promotes inflammatory cytokines secretion, lung fibrosis and cell apoptosis, inhibits cell proliferation in mice models by regulating Keap1/p65/Nrf2 signal pathway.	Paraquat	47-49	kelch-like ECH-associated protein 1	Mus musculus	184-189
30734183-8	2019	Therefore, we concluded that high-dose PQ (500 muM) inhibits 16HBE cell proliferation and autophagy, promotes cell death and mice lung fibrosis by regulating Keap1/p65/Nrf2 signal pathway.	Paraquat	39-41	kelch-like ECH-associated protein 1	Mus musculus	158-163
30734183-0	2019	High-Dose Paraquat Induces Human Bronchial 16HBE Cell Death and Aggravates Acute Lung Intoxication in Mice by Regulating Keap1/p65/Nrf2 Signal Pathway.	Paraquat	10-18	kelch-like ECH-associated protein 1	Mus musculus	121-126
30735010-0	2019	The discovery and characterization of K-563, a novel inhibitor of the Keap1/Nrf2 pathway produced by Streptomyces sp.	k-563	38-43	kelch-like ECH-associated protein 1	Mus musculus	70-75
30735010-6	2019	Through this screening, we identified the novel Keap1/Nrf2 pathway inhibitor K-563, which was isolated from actinomycete Streptomyces sp.	k-563	77-82	kelch-like ECH-associated protein 1	Mus musculus	48-53
30735010-7	2019	K-563 suppressed the expression of Keap1/Nrf2 pathway downstream target genes or the downstream target protein, which induced suppression of GSH production, and activated reactive oxygen species production in A549 cells.	Glutathione	141-144	kelch-like ECH-associated protein 1	Mus musculus	35-40
30735010-12	2019	An in vivo study in mice xenotransplanted with A549 cells to further explore the therapeutic potential of K-563 revealed that it also inhibited Keap1/Nrf2 pathway in lung cancer tumors.	k-563	106-111	kelch-like ECH-associated protein 1	Mus musculus	144-149
30735010-13	2019	K-563, a novel Keap1/Nrf2 pathway inhibitor, may be a lead compound for development as an anti-cancer agent.	k-563	0-5	kelch-like ECH-associated protein 1	Mus musculus	15-20
32454696-10	2019	Monochloropivaloylquercetin decreased cytoplasmic Keap1 levels and increased nuclear translocation of Nrf-2 resulted in induction of HO-1 and NQO1 expression.	monochloropivaloylquercetin	0-27	kelch-like ECH-associated protein 1	Mus musculus	50-55
30553970-7	2019	Furthermore, ramelteon decreased Keap 1 expression, promoted nuclear factor erythroid 2-related factor 2 (Nrf2) nuclear accumulation, and increased levels of downstream proteins, including SOD-1, heme oxygenase-1, and NQO1 on day 3 post-TBI.	ramelteon	13-22	kelch-like ECH-associated protein 1	Mus musculus	33-39
30483753-8	2019	By contrast, downregulation of miR-140-5p decreased oxidative stress and ROS levels by activating the protein expression of Nrf2, Sirt2, Keap1 and HO-1 in vitro.	Reactive Oxygen Species	73-76	kelch-like ECH-associated protein 1	Mus musculus	137-142
30760288-2	2019	Nuclear factor-E2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1)-antioxidant response element (ARE) signaling pathway works as an essential defense mechanism against oxidative stress, and an oral drug Dimethylfumarate (DMF) is known to activate the pathway.	Dimethyl Fumarate	222-238	kelch-like ECH-associated protein 1	Mus musculus	42-77
30760288-2	2019	Nuclear factor-E2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1)-antioxidant response element (ARE) signaling pathway works as an essential defense mechanism against oxidative stress, and an oral drug Dimethylfumarate (DMF) is known to activate the pathway.	Dimethyl Fumarate	222-238	kelch-like ECH-associated protein 1	Mus musculus	79-84
30760288-2	2019	Nuclear factor-E2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1)-antioxidant response element (ARE) signaling pathway works as an essential defense mechanism against oxidative stress, and an oral drug Dimethylfumarate (DMF) is known to activate the pathway.	Dimethyl Fumarate	240-243	kelch-like ECH-associated protein 1	Mus musculus	42-77
30760288-2	2019	Nuclear factor-E2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1)-antioxidant response element (ARE) signaling pathway works as an essential defense mechanism against oxidative stress, and an oral drug Dimethylfumarate (DMF) is known to activate the pathway.	Dimethyl Fumarate	240-243	kelch-like ECH-associated protein 1	Mus musculus	79-84
30760288-7	2019	CONCLUSIONS: Our data suggest that DMF administration activates the Nrf2/Keap1 pathway, elevate levels of antioxidants, and decrease DNA damage and oxidative stress, resulting in improved ovarian reserve in the mouse ovary.	Dimethyl Fumarate	35-38	kelch-like ECH-associated protein 1	Mus musculus	73-78
30535776-0	2019	Ginsenoside Compound K Regulates Amyloid beta via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments.	Ginsenosides	0-11	kelch-like ECH-associated protein 1	Mus musculus	59-64
30365933-4	2019	A docking simulation suggested that the alpha, beta-unsaturated carbonyl of shogaol but not gingerol interacts with Keap1.	shogaol	76-83	kelch-like ECH-associated protein 1	Mus musculus	116-121
30365933-9	2019	Thus, the alpha, beta-unsaturated carbonyl is necessary for the interaction of compounds, such as shogaol, with Keap1, and these findings may be useful for screening novel ICH therapeutic agents that increase HO-1 expression.	-unsaturated	21-33	kelch-like ECH-associated protein 1	Mus musculus	112-117
30365933-9	2019	Thus, the alpha, beta-unsaturated carbonyl is necessary for the interaction of compounds, such as shogaol, with Keap1, and these findings may be useful for screening novel ICH therapeutic agents that increase HO-1 expression.	shogaol	98-105	kelch-like ECH-associated protein 1	Mus musculus	112-117
30396067-0	2019	Farrerol attenuates beta-amyloid-induced oxidative stress and inflammation through Nrf2/Keap1 pathway in a microglia cell line.	farrerol	0-8	kelch-like ECH-associated protein 1	Mus musculus	88-93
30396067-12	2019	In addition, farrerol enhanced the activation of Nrf2/Keap1 pathway in Abeta-induced BV-2 cells.	farrerol	13-21	kelch-like ECH-associated protein 1	Mus musculus	54-59
30396067-14	2019	In conclusion, farrerol attenuated Abeta-induced oxidative stress and inflammation in BV-2 cells through enhancing the activation of Nrf2/Keap1 pathway.	farrerol	15-23	kelch-like ECH-associated protein 1	Mus musculus	138-143
30396067-14	2019	In conclusion, farrerol attenuated Abeta-induced oxidative stress and inflammation in BV-2 cells through enhancing the activation of Nrf2/Keap1 pathway.	UNII-042A8N37WH	35-40	kelch-like ECH-associated protein 1	Mus musculus	138-143
30352880-4	2019	Nrf2 is basally active, but in chronic ROS, we found irregular inhibition of Nrf2 by Keap1, altered metabolism, and limited BMSC multipotency.	Reactive Oxygen Species	39-42	kelch-like ECH-associated protein 1	Mus musculus	85-90
30535776-7	2019	Ginsenoside CK was found to enhance memory function, normalize neuronal morphology, decrease neuronal apoptosis, increase superoxide dismutase and glutathione peroxidase levels, reduce malondialdehyde levels, inhibit Abeta expression, and activate the Nrf2/Keap1 signaling pathway in scopolamine-exposed animals.	Ginsenosides	0-11	kelch-like ECH-associated protein 1	Mus musculus	257-262
30215777-5	2019	Two weeks after DDC feeding, Keap1-Alb mice were fully recovered from body weight loss, but the WT and Nrf2KO mice were not.	Zalcitabine	16-19	kelch-like ECH-associated protein 1	Mus musculus	29-34
30215777-8	2019	DDC-induced porphyrin accumulation was reduced in the livers of Keap1-Alb and Keap1KD mice compared with that of WT mice.	Zalcitabine	0-3	kelch-like ECH-associated protein 1	Mus musculus	64-69
30215777-8	2019	DDC-induced porphyrin accumulation was reduced in the livers of Keap1-Alb and Keap1KD mice compared with that of WT mice.	Porphyrins	12-21	kelch-like ECH-associated protein 1	Mus musculus	64-69
30215777-10	2019	Genetic activation of Nrf2 in Keap1-Alb mice increased the extracellular excretion of porphyrins, but contrary to our expectation, hepatic damages in Nrf2KO mice appeared to be similar to that of WT mice.	Porphyrins	86-96	kelch-like ECH-associated protein 1	Mus musculus	30-35
30538709-0	2018	DC32, a Dihydroartemisinin Derivative, Ameliorates Collagen-Induced Arthritis Through an Nrf2-p62-Keap1 Feedback Loop.	dc32	0-4	kelch-like ECH-associated protein 1	Mus musculus	98-103
30619098-6	2018	Furthermore, PHL decreased the levels of serum lactate dehydrogenase, aspartate aminotransferase, and creatine kinase-MB, and attenuated the progress in the fibrosis, oxidative stress, and pathological parameters via Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor E2-related factor 2 (Nrf2) pathway in diabetic mice.	Phloretin	13-16	kelch-like ECH-associated protein 1	Mus musculus	217-252
30619098-6	2018	Furthermore, PHL decreased the levels of serum lactate dehydrogenase, aspartate aminotransferase, and creatine kinase-MB, and attenuated the progress in the fibrosis, oxidative stress, and pathological parameters via Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor E2-related factor 2 (Nrf2) pathway in diabetic mice.	Phloretin	13-16	kelch-like ECH-associated protein 1	Mus musculus	254-259
29742356-0	2019	Schisandrin B alleviates acute oxidative stress via modulation of the Nrf2/Keap1-mediated antioxidant pathway.	schizandrin B	0-13	kelch-like ECH-associated protein 1	Mus musculus	75-80
29742356-7	2019	Several proteins, such as Nrf2 and its endogenous inhibitor Kelch-like ECH-associated protein 1 (Keap1), were abnormally expressed in mice subjected to forced swimming, but this abnormal expression was significantly reversed by Sch B treatment.	schizandrin B	228-233	kelch-like ECH-associated protein 1	Mus musculus	60-95
29742356-7	2019	Several proteins, such as Nrf2 and its endogenous inhibitor Kelch-like ECH-associated protein 1 (Keap1), were abnormally expressed in mice subjected to forced swimming, but this abnormal expression was significantly reversed by Sch B treatment.	schizandrin B	228-233	kelch-like ECH-associated protein 1	Mus musculus	97-102
30622671-10	2018	The results from this study suggest a novel function of miR-24-3p in protecting cardiomyocytes from ischemia/reperfusion injury by the activation of the Nrf2-Keap1 pathway.	mir-24-3p	56-65	kelch-like ECH-associated protein 1	Mus musculus	158-163
30288658-10	2018	These results suggested that Se protected the liver from the Al-induced hepatotoxicity by regulating the mRNA level of Keap1/Nrf2/HO-1, and inhibited inflammatory responses by down-regulating the expression level of inflammatory cytokine.	Aluminum	61-63	kelch-like ECH-associated protein 1	Mus musculus	119-124
30538709-0	2018	DC32, a Dihydroartemisinin Derivative, Ameliorates Collagen-Induced Arthritis Through an Nrf2-p62-Keap1 Feedback Loop.	artenimol	8-26	kelch-like ECH-associated protein 1	Mus musculus	98-103
30538709-8	2018	Administration of DC32 could inhibit the activation of Akt/mTOR and ERK, and pretreatment of NIH-3T3 cells with the autophagy inhibitor 3-methyladenine (3-MA) attenuated the degradation of Keap1 induced by DC32.	dc32	18-22	kelch-like ECH-associated protein 1	Mus musculus	189-194
30538709-8	2018	Administration of DC32 could inhibit the activation of Akt/mTOR and ERK, and pretreatment of NIH-3T3 cells with the autophagy inhibitor 3-methyladenine (3-MA) attenuated the degradation of Keap1 induced by DC32.	3-methyladenine	136-151	kelch-like ECH-associated protein 1	Mus musculus	189-194
30538709-8	2018	Administration of DC32 could inhibit the activation of Akt/mTOR and ERK, and pretreatment of NIH-3T3 cells with the autophagy inhibitor 3-methyladenine (3-MA) attenuated the degradation of Keap1 induced by DC32.	3-methyladenine	153-157	kelch-like ECH-associated protein 1	Mus musculus	189-194
30538709-8	2018	Administration of DC32 could inhibit the activation of Akt/mTOR and ERK, and pretreatment of NIH-3T3 cells with the autophagy inhibitor 3-methyladenine (3-MA) attenuated the degradation of Keap1 induced by DC32.	dc32	206-210	kelch-like ECH-associated protein 1	Mus musculus	189-194
30568426-0	2018	Schisandrin B elicits the Keap1-Nrf2 defense system via carbene reactive metabolite which is less harmful to mice liver.	schizandrin B	0-13	kelch-like ECH-associated protein 1	Mus musculus	26-31
30568426-0	2018	Schisandrin B elicits the Keap1-Nrf2 defense system via carbene reactive metabolite which is less harmful to mice liver.	carbene	56-63	kelch-like ECH-associated protein 1	Mus musculus	26-31
30568426-11	2018	Conclusion: The present study revealed that CYP450s mediate the conversion of Sch B to carbene, which subsequently binds to Keap1 and elicits Nrf2 pathway, which could further increase the elimination of carbene and thus exhibit a less harmful effect on mice liver.	schizandrin B	78-83	kelch-like ECH-associated protein 1	Mus musculus	124-129
30568426-11	2018	Conclusion: The present study revealed that CYP450s mediate the conversion of Sch B to carbene, which subsequently binds to Keap1 and elicits Nrf2 pathway, which could further increase the elimination of carbene and thus exhibit a less harmful effect on mice liver.	carbene	87-94	kelch-like ECH-associated protein 1	Mus musculus	124-129
30568426-11	2018	Conclusion: The present study revealed that CYP450s mediate the conversion of Sch B to carbene, which subsequently binds to Keap1 and elicits Nrf2 pathway, which could further increase the elimination of carbene and thus exhibit a less harmful effect on mice liver.	carbene	204-211	kelch-like ECH-associated protein 1	Mus musculus	124-129
30375618-0	2018	Protective effects of sesamol on systemic oxidative stress-induced cognitive impairments via regulation of Nrf2/Keap1 pathway.	sesamol	22-29	kelch-like ECH-associated protein 1	Mus musculus	112-117
30507922-2	2018	We have previously shown that dysfunction of the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/ Kelch-like erythroid cell-derived protein 1 (Keap1) signaling pathway leads to extreme ROS imbalance during cutaneous wound healing in diabetes.	Reactive Oxygen Species	188-191	kelch-like ECH-associated protein 1	Mus musculus	146-151
30507922-9	2018	Here, we describe a protocol utilizing L-012-facilitated in vivo imaging to quantify oxidative stress in a model of excisional wound healing using diabetic mice with locally dysfunctional Nrf2/Keap1.	L 012	39-44	kelch-like ECH-associated protein 1	Mus musculus	193-198
30077706-6	2018	Stimulation by LPS suppressed both antioxidant enzyme activities and expressions, and Keap1-Nrf2 signaling pathway which was significantly (p &lt; 0.05) increased in the presence of MH.	mh	182-184	kelch-like ECH-associated protein 1	Mus musculus	86-91
30683827-7	2018	Nrf2 activations after keap1 inactivation led to significant increases in HO-1 after 168 hours of DSS administration, when NF-kappaB nuclear translocation was noted.	Dextran Sulfate	98-101	kelch-like ECH-associated protein 1	Mus musculus	23-28
30140996-7	2018	The importance of Nrf2 for cellular functions and survival after SA treatment was elucidated by in vitro knockdown experiments with shRNA directed against Nrf2 and its inhibitor Keap1 as well as by methysticin treatment.	Sodium Azide	65-67	kelch-like ECH-associated protein 1	Mus musculus	178-183
29940171-4	2018	By utilizing Keap1-/- MEFs reconstituted with Keap1 mutants harboring substitutions in their major cysteine residues, we clarified the importance of Cys151 in Keap1 as a sensor for 5-HI in the induction of Nrf2 expression.	5-hydroxyindole	181-185	kelch-like ECH-associated protein 1	Mus musculus	13-18
29940171-4	2018	By utilizing Keap1-/- MEFs reconstituted with Keap1 mutants harboring substitutions in their major cysteine residues, we clarified the importance of Cys151 in Keap1 as a sensor for 5-HI in the induction of Nrf2 expression.	5-hydroxyindole	181-185	kelch-like ECH-associated protein 1	Mus musculus	46-51
29940171-4	2018	By utilizing Keap1-/- MEFs reconstituted with Keap1 mutants harboring substitutions in their major cysteine residues, we clarified the importance of Cys151 in Keap1 as a sensor for 5-HI in the induction of Nrf2 expression.	5-hydroxyindole	181-185	kelch-like ECH-associated protein 1	Mus musculus	46-51
30021365-11	2018	In summary, we demonstrated that apigenin prevented high fructose-induced metabolic syndrome probably by inhibiting binding of Keap1 to Nrf2, and thus Nrf2 nuclear translocation, subsequently resulting in increased the expressions of anti-oxidative genes including HO-1 and NQO1.	Fructose	57-65	kelch-like ECH-associated protein 1	Mus musculus	127-132
29940171-3	2018	5-HI induced the expression of the transcription factor, Nrf2, which is typically ubiquitinated by Keap1, an adaptor component of the ubiquitin E3 ligase complex, resulting in its proteasomal degradation.	5-hydroxyindole	0-4	kelch-like ECH-associated protein 1	Mus musculus	99-104
30116489-5	2018	The effect of DOP on the Kelch-like ECH-associated protein 1- (Keap1-) nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway was evaluated using Western blot analysis and real-time polymerase chain reaction (PCR).	Diethylhexyl Phthalate	14-17	kelch-like ECH-associated protein 1	Mus musculus	25-60
30200495-0	2018	Ginsenoside Rh2 Ameliorates Lipopolysaccharide-Induced Acute Lung Injury by Regulating the TLR4/PI3K/Akt/mTOR, Raf-1/MEK/ERK, and Keap1/Nrf2/HO-1 Signaling Pathways in Mice.	ginsenoside Rh2	0-15	kelch-like ECH-associated protein 1	Mus musculus	130-135
29959995-4	2018	Our findings suggested that Ori exposure effectively alleviated H2O2-stimulated cytotoxicity, inhibited reactive oxygen species (ROS) generation, and glutathione (GSH) depletion, which were involved in induction of heme oxygenase-1 (HO-1) by enhancing the nuclear factor-erythroid 2-related factor 2 (Nrf2) translocation, decreasing the Keap1 protein expression, and increasing the antioxidant response element (ARE) activity.	Hydrogen Peroxide	64-68	kelch-like ECH-associated protein 1	Mus musculus	337-342
30116489-0	2018	Hepatoprotective Effect of Polysaccharides Isolated from Dendrobium officinale against Acetaminophen-Induced Liver Injury in Mice via Regulation of the Nrf2-Keap1 Signaling Pathway.	Polysaccharides	27-42	kelch-like ECH-associated protein 1	Mus musculus	157-162
30116489-5	2018	The effect of DOP on the Kelch-like ECH-associated protein 1- (Keap1-) nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway was evaluated using Western blot analysis and real-time polymerase chain reaction (PCR).	Diethylhexyl Phthalate	14-17	kelch-like ECH-associated protein 1	Mus musculus	63-68
30116489-8	2018	DOP treatment significantly induced the dissociation of Nrf2 from the Nrf2-Keap1 complex and promoted the Nrf2 nuclear translocation.	Diethylhexyl Phthalate	0-3	kelch-like ECH-associated protein 1	Mus musculus	75-80
30116489-11	2018	Further investigation about mechanisms indicated that DOP exerted the hepatoprotective effect by suppressing the oxidative stress and activating the Nrf2-Keap1 signaling pathway.	Diethylhexyl Phthalate	54-57	kelch-like ECH-associated protein 1	Mus musculus	154-159
29554619-0	2018	Diphenyl diselenide regulates Nrf2/Keap-1 signaling pathway and counteracts hepatic oxidative stress induced by bisphenol A in male mice.	diphenyldiselenide	0-19	kelch-like ECH-associated protein 1	Mus musculus	35-41
29554619-3	2018	Diphenyl diselenide (PhSe)2 improves the antioxidant response via activation of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/Kelch-like ECH-associated protein (keap 1) pathway in macrophage cells.	diphenyldiselenide	0-19	kelch-like ECH-associated protein 1	Mus musculus	135-176
29554619-3	2018	Diphenyl diselenide (PhSe)2 improves the antioxidant response via activation of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/Kelch-like ECH-associated protein (keap 1) pathway in macrophage cells.	phse	21-25	kelch-like ECH-associated protein 1	Mus musculus	135-176
29554619-14	2018	BPA decreased Nrf2/Keap1 protein content in male mice.	bisphenol A	0-3	kelch-like ECH-associated protein 1	Mus musculus	19-24
29455993-0	2018	Polysaccharide from Ostrea rivularis attenuates reproductive oxidative stress damage via activating Keap1-Nrf2/ARE pathway.	Polysaccharides	0-14	kelch-like ECH-associated protein 1	Mus musculus	100-105
29748743-14	2018	Confocal microscopy revealed nuclear translocation of Nrf2 (the key event in Keap1/Nrf2 signaling) induced by apo-rhLF (iron-free, RPMI-1640).	Iron	120-124	kelch-like ECH-associated protein 1	Mus musculus	77-82
29748743-14	2018	Confocal microscopy revealed nuclear translocation of Nrf2 (the key event in Keap1/Nrf2 signaling) induced by apo-rhLF (iron-free, RPMI-1640).	rpmi-1640	131-140	kelch-like ECH-associated protein 1	Mus musculus	77-82
29899699-1	2018	Background and Aim: To investigate whether double-knockdown of PHD1 and Keap1 in mice could enhance the resolution of carbon tetrachloride (CCl4)-induced liver fibrosis.	Carbon Tetrachloride	118-138	kelch-like ECH-associated protein 1	Mus musculus	72-77
29455993-4	2018	In addition, ORP treatment could improve survival capacity of H2O2-induced TM4 cells and its antioxidant mechanism in vitro also had been verified to activate Keap1-Nrf2/ARE signaling pathway.	Hydrogen Peroxide	62-66	kelch-like ECH-associated protein 1	Mus musculus	159-164
29455993-1	2018	The purpose of this study was to investigate the effects of Ostrea rivularis polysaccharide (ORP) against testicular oxidative stress injury via kelch-like ECH-associated protein 1-nuclear erythroid 2-related factor 2/antioxidant response element (Keap1-Nrf2/ARE) pathway.	Polysaccharides	77-91	kelch-like ECH-associated protein 1	Mus musculus	248-253
29305174-0	2018	Inhibition of autophagy reverses alcohol-induced hepatic stellate cells activation through activation of Nrf2-Keap1-ARE signaling pathway.	Alcohols	33-40	kelch-like ECH-associated protein 1	Mus musculus	110-115
29338970-11	2018	In summary, baicalein and baicalin alleviate APAP-induced hepatotoxicity by activating Nrf2 via blocking the binding of Nrf2 with Keap1 and inducing Nrf2 phosphorylation.	Acetaminophen	45-49	kelch-like ECH-associated protein 1	Mus musculus	130-135
29154192-0	2018	Resveratrol attenuates testicular apoptosis in type 1 diabetic mice: Role of Akt-mediated Nrf2 activation and p62-dependent Keap1 degradation.	Resveratrol	0-11	kelch-like ECH-associated protein 1	Mus musculus	124-129
29154192-9	2018	In addition, RSV-induced Nrf2 activation was found due to Keap1 degradation, mainly reliant on p62 that functions as an adaptor protein during autophagy.	Resveratrol	13-16	kelch-like ECH-associated protein 1	Mus musculus	58-63
29154192-10	2018	These results indicate that the attenuation of T1D-induced testicular oxidative stress and apoptosis by RSV treatment was mainly related to Akt-mediated Nrf2 activation via p62-dependent Keap1 degradation.	Resveratrol	104-107	kelch-like ECH-associated protein 1	Mus musculus	187-192
29136249-10	2018	These results suggest that CGA protects against APAP-induced hepatotoxicity by activating Nrf2 antioxidative signaling pathway via blocking the binding of Nrf2 to its inhibitor protein Keap1, and ERK1/2 plays a critical role in regulating CGA-induced Nrf2 transcriptional activation.	Acetaminophen	48-52	kelch-like ECH-associated protein 1	Mus musculus	185-190
29628888-4	2018	Our findings indicated that Lico A effectively decreased tert-butyl hydroperoxide (t-BHP)- and APAP-stimulated cell apoptosis, mitochondrial dysfunction and reactive oxygen species generation and increased various anti-oxidative enzymes expression, which is largely dependent on upregulating Nrf2 nuclear translocation, reducing the Keap1 protein expression, and strengthening the antioxidant response element promoter activity.	licochalcone A	28-34	kelch-like ECH-associated protein 1	Mus musculus	333-338
29655681-13	2018	Despite KLA induced the phosphorylation of mitogen-activated protein kinases (MAPKs) family, inhibiting the phosphorylation of p38 by its specific inhibitor SB203580 attenuated the degradation of KLA-induced Keap1, and then reduced KLA-induced Nrf2 nuclear translocation and HO-1 expression.	SB 203580	157-165	kelch-like ECH-associated protein 1	Mus musculus	208-213
29655681-13	2018	Despite KLA induced the phosphorylation of mitogen-activated protein kinases (MAPKs) family, inhibiting the phosphorylation of p38 by its specific inhibitor SB203580 attenuated the degradation of KLA-induced Keap1, and then reduced KLA-induced Nrf2 nuclear translocation and HO-1 expression.	CHEMBL4446153	196-199	kelch-like ECH-associated protein 1	Mus musculus	208-213
29655681-13	2018	Despite KLA induced the phosphorylation of mitogen-activated protein kinases (MAPKs) family, inhibiting the phosphorylation of p38 by its specific inhibitor SB203580 attenuated the degradation of KLA-induced Keap1, and then reduced KLA-induced Nrf2 nuclear translocation and HO-1 expression.	CHEMBL4446153	196-199	kelch-like ECH-associated protein 1	Mus musculus	208-213
29273684-0	2018	SP600125 suppresses Keap1 expression and results in NRF2-mediated prevention of diabetic nephropathy.	pyrazolanthrone	0-8	kelch-like ECH-associated protein 1	Mus musculus	20-25
29233793-0	2018	Licochalcone A activates Keap1-Nrf2 signaling to suppress arthritis via phosphorylation of p62 at serine 349.	licochalcone A	0-14	kelch-like ECH-associated protein 1	Mus musculus	25-30
29233793-0	2018	Licochalcone A activates Keap1-Nrf2 signaling to suppress arthritis via phosphorylation of p62 at serine 349.	Serine	98-104	kelch-like ECH-associated protein 1	Mus musculus	25-30
29233793-8	2018	In coincided with in vivo results, LCA inhibited the cell proliferation and arrested the cell cycle, induced apoptosis, suppressed pro-inflammatory cytokine secretion and increased expression of antioxidant enzymes via the activation of Keap1-Nrf2 signaling by enhancing p62 phosphorylation and expression, Nrf2 accumulation and Nrf2 nucleus translocation.	licochalcone A	35-38	kelch-like ECH-associated protein 1	Mus musculus	237-242
29233793-9	2018	Findings in the current study provide evidence that p62-Keap1-Nrf2 axis is a pivotal signaling pathway in development of arthritis and therapeutic efficacy of drugs, and LCA activates of Keap1-Nrf2 signaling to suppress arthritis by phosphorylation of p62 at Ser349.	licochalcone A	170-173	kelch-like ECH-associated protein 1	Mus musculus	56-61
29233793-9	2018	Findings in the current study provide evidence that p62-Keap1-Nrf2 axis is a pivotal signaling pathway in development of arthritis and therapeutic efficacy of drugs, and LCA activates of Keap1-Nrf2 signaling to suppress arthritis by phosphorylation of p62 at Ser349.	licochalcone A	170-173	kelch-like ECH-associated protein 1	Mus musculus	187-192
29233793-10	2018	Collectively, LCA is valuable to be further investigated as a lead compound for application in anti-arthritis, and interference with the interaction between Nrf2 and Keap1 by phosphorylation of p62 may be a promising strategy for the discovery of anti-arthritic agents.	licochalcone A	14-17	kelch-like ECH-associated protein 1	Mus musculus	166-171
29331651-0	2018	Activation of p62-keap1-Nrf2 antioxidant pathway in the early stage of acetaminophen-induced acute liver injury in mice.	Acetaminophen	71-84	kelch-like ECH-associated protein 1	Mus musculus	18-23
29331651-11	2018	Taken together, these results indicated that p62-keap1-Nrf2 antioxidant pathway was primarily activated in the early stage of APAP hepatotoxicity, which might play a protective role in the process of APAP-induced acute liver injury.	Acetaminophen	126-130	kelch-like ECH-associated protein 1	Mus musculus	49-54
29175486-8	2018	15k-PGE2 further demonstrated modification to Kelch-like ECH-associated protein 1 (Keap1), a negative regulator of Nrf2, at cysteine 288 (Cys288) site post-translationally.	Dinoprostone	4-8	kelch-like ECH-associated protein 1	Mus musculus	46-81
29175486-8	2018	15k-PGE2 further demonstrated modification to Kelch-like ECH-associated protein 1 (Keap1), a negative regulator of Nrf2, at cysteine 288 (Cys288) site post-translationally.	Dinoprostone	4-8	kelch-like ECH-associated protein 1	Mus musculus	83-88
29175486-8	2018	15k-PGE2 further demonstrated modification to Kelch-like ECH-associated protein 1 (Keap1), a negative regulator of Nrf2, at cysteine 288 (Cys288) site post-translationally.	Cysteine	124-132	kelch-like ECH-associated protein 1	Mus musculus	46-81
29175486-8	2018	15k-PGE2 further demonstrated modification to Kelch-like ECH-associated protein 1 (Keap1), a negative regulator of Nrf2, at cysteine 288 (Cys288) site post-translationally.	Cysteine	124-132	kelch-like ECH-associated protein 1	Mus musculus	83-88
29273684-9	2018	SP600125 inactivated JNK, inhibited kelch-like ECH-associated protein 1 expression, preserved NRF2 protein and facilitated its nuclear translocation in the kidneys of the WT mice, the effects of which were similarly produced by either SP600125 or JNK siRNA in HG-treated MMCs.	pyrazolanthrone	0-8	kelch-like ECH-associated protein 1	Mus musculus	36-71
29273684-12	2018	SP600125 activates NRF2 possibly via inhibition of JNK-induced Keap1 expression.	pyrazolanthrone	0-8	kelch-like ECH-associated protein 1	Mus musculus	63-68
29255269-3	2018	ROS-induced cell-death signaling involved interactions among the cellular ROS sensor and antioxidant factor KEAP1, the phosphatase PGAM5 and the proapoptotic factor AIFM1.	Reactive Oxygen Species	0-3	kelch-like ECH-associated protein 1	Mus musculus	108-113
28971839-9	2018	KC::Keap1 and KPC::Keap1 mice presented lower body weight and glucose levels than C::Keap1 mice, presumably resulting from pancreatic exocrine insufficiency.	Glucose	62-69	kelch-like ECH-associated protein 1	Mus musculus	19-24
28971839-9	2018	KC::Keap1 and KPC::Keap1 mice presented lower body weight and glucose levels than C::Keap1 mice, presumably resulting from pancreatic exocrine insufficiency.	Glucose	62-69	kelch-like ECH-associated protein 1	Mus musculus	19-24
28971839-14	2018	NEW &amp; NOTEWORTHY Aberrant activation of the Kelch-like ECH-associated protein 1 (Keap1)-NF-E2-related factor 2 (Nrf2) system usually promotes carcinogenesis, and we assumed that simultaneous activation of K-ras and Nrf2 might promote pancreatic carcinogenesis.	Adenosine Monophosphate	5-8	kelch-like ECH-associated protein 1	Mus musculus	48-83
28971839-14	2018	NEW &amp; NOTEWORTHY Aberrant activation of the Kelch-like ECH-associated protein 1 (Keap1)-NF-E2-related factor 2 (Nrf2) system usually promotes carcinogenesis, and we assumed that simultaneous activation of K-ras and Nrf2 might promote pancreatic carcinogenesis.	Adenosine Monophosphate	5-8	kelch-like ECH-associated protein 1	Mus musculus	85-90
29768946-11	2018	In contrast, chronic exposure to dopamine induced moderate increases in PPP activity via the Keap1/Nrf2 system.	Dopamine	33-41	kelch-like ECH-associated protein 1	Mus musculus	93-98
29117896-7	2018	The obtained novel cyclic peptide 3 showed high binding affinity with Keap1 and possessed high potency in Nrf2 activation at cellular level.	cyclic peptide 3	19-35	kelch-like ECH-associated protein 1	Mus musculus	70-75
29064158-0	2018	The natural compound 2,3,5,4"-tetrahydroxystilbene-2-O-beta-d glucoside protects against adriamycin-induced nephropathy through activating the Nrf2-Keap1 antioxidant pathway.	Doxorubicin	89-99	kelch-like ECH-associated protein 1	Mus musculus	148-153
29064158-12	2018	Silencing Nrf2 and its repressor protein, Kelch-like ECH-associated protein 1 (Keap1), abolished these protective effects of THSG.	2,3,5,4'-tetrahydroxystilbene 2-O-glucopyranoside	125-129	kelch-like ECH-associated protein 1	Mus musculus	42-77
29064158-12	2018	Silencing Nrf2 and its repressor protein, Kelch-like ECH-associated protein 1 (Keap1), abolished these protective effects of THSG.	2,3,5,4'-tetrahydroxystilbene 2-O-glucopyranoside	125-129	kelch-like ECH-associated protein 1	Mus musculus	79-84
29064158-13	2018	In conclusion, THSG can play a protective role in ameliorating the progression of FSGS in a mouse model through activation of the Nrf2-Keap1 antioxidant pathway.	2,3,5,4'-tetrahydroxystilbene 2-O-glucopyranoside	15-19	kelch-like ECH-associated protein 1	Mus musculus	135-140
28928081-0	2017	MicroRNA-140-5p attenuated oxidative stress in Cisplatin induced acute kidney injury by activating Nrf2/ARE pathway through a Keap1-independent mechanism.	Cisplatin	47-56	kelch-like ECH-associated protein 1	Mus musculus	126-131
29125494-7	2018	The results of this study also demonstrated that tetrahydroxystilbene glucoside increased Nrf2 and HO-1 protein expression and decreased Keap1 protein expression in a concentration-dependent manner in Abeta1-42-treated mice, which involved in the Keap1/Nrf2 antioxidant pathway in hippocampus and cerebral cortex tissue.	2',3',4',5'-tetrahydroxystilbene-2-O-beta-D-glucoside	49-79	kelch-like ECH-associated protein 1	Mus musculus	137-142
29125494-7	2018	The results of this study also demonstrated that tetrahydroxystilbene glucoside increased Nrf2 and HO-1 protein expression and decreased Keap1 protein expression in a concentration-dependent manner in Abeta1-42-treated mice, which involved in the Keap1/Nrf2 antioxidant pathway in hippocampus and cerebral cortex tissue.	2',3',4',5'-tetrahydroxystilbene-2-O-beta-D-glucoside	49-79	kelch-like ECH-associated protein 1	Mus musculus	247-252
29158022-4	2018	It showed high binding affinity to the Nrf2 inhibitory protein Keap-1 and increased nuclear translocation of Nrf2 and gene expression of the antioxidant enzymes heme oxygenase-1, NAD(P)H:quinone oxidoreductase-1, and the catalytic and modifier subunits of glutamate-cysteine ligase in dopaminergic CATH.a cells.	glutamate cysteine	256-274	kelch-like ECH-associated protein 1	Mus musculus	63-69
29425659-15	2018	Furthermore, SP decreased the expression of Keap-1 and increased the nuclear expression of Nrf-2.	sp	13-15	kelch-like ECH-associated protein 1	Mus musculus	44-50
29285281-7	2017	Meanwhile, Keap1 shRNA took over MIND4-17"s actions and protected OB-6 cells from H2O2.	Hydrogen Peroxide	82-86	kelch-like ECH-associated protein 1	Mus musculus	11-16
28842592-0	2017	Neglected role of hydrogen sulfide in sulfur mustard poisoning: Keap1 S-sulfhydration and subsequent Nrf2 pathway activation.	Hydrogen Sulfide	18-34	kelch-like ECH-associated protein 1	Mus musculus	64-69
29049341-4	2017	The Nrf2-Keap1 interaction is disrupted by the environmental toxicant and chemotherapeutic agent arsenic trioxide (ATO).	Arsenic Trioxide	97-113	kelch-like ECH-associated protein 1	Mus musculus	9-14
29049341-4	2017	The Nrf2-Keap1 interaction is disrupted by the environmental toxicant and chemotherapeutic agent arsenic trioxide (ATO).	Arsenic Trioxide	115-118	kelch-like ECH-associated protein 1	Mus musculus	9-14
28828752-7	2017	DBM treatment resulted in dissociation from Keap1 and nuclear translocation of Nrf2.	dibenzoylmethane	0-3	kelch-like ECH-associated protein 1	Mus musculus	44-49
28826090-7	2017	Curcumin increased Nrf2 expression and nuclear translocation, and its binding activity to DNA, which might be associated with suppression of Kelch-like ECH-associated protein 1 in HSCs.	Curcumin	0-8	kelch-like ECH-associated protein 1	Mus musculus	141-176
28842592-10	2017	Furthermore, we also found that H2S S-sulfhydrated Keap1, which induced Nrf2 dissociation from Keap1, and enhanced Nrf2 nuclear translocation.	Hydrogen Sulfide	32-35	kelch-like ECH-associated protein 1	Mus musculus	51-56
28842592-10	2017	Furthermore, we also found that H2S S-sulfhydrated Keap1, which induced Nrf2 dissociation from Keap1, and enhanced Nrf2 nuclear translocation.	Hydrogen Sulfide	32-35	kelch-like ECH-associated protein 1	Mus musculus	95-100
28796243-7	2017	NaHS increased the expression of Kelch-like ECH-associated protein 1 (Keap-1) and reduced the ubiquitylation level in the hearts of db/db mice.	sodium bisulfide	0-4	kelch-like ECH-associated protein 1	Mus musculus	33-68
29285219-7	2017	Keap1 shRNA also activated Nrf2 and protected OB-6 cells from dexamethasone.	Dexamethasone	62-75	kelch-like ECH-associated protein 1	Mus musculus	0-5
28796243-7	2017	NaHS increased the expression of Kelch-like ECH-associated protein 1 (Keap-1) and reduced the ubiquitylation level in the hearts of db/db mice.	sodium bisulfide	0-4	kelch-like ECH-associated protein 1	Mus musculus	70-76
28796243-8	2017	1,4-Dithiothreitol, an inhibitor of disulphide bonds, increased the ubiquitylation level of Keap-1, suppressed the expression of Keap-1 and abolished the effects of NaHS on ubiquitin aggregate clearance and ROS production in H9C2 cells treated with high glucose and palmitate.	Dithiothreitol	0-18	kelch-like ECH-associated protein 1	Mus musculus	92-98
28796243-8	2017	1,4-Dithiothreitol, an inhibitor of disulphide bonds, increased the ubiquitylation level of Keap-1, suppressed the expression of Keap-1 and abolished the effects of NaHS on ubiquitin aggregate clearance and ROS production in H9C2 cells treated with high glucose and palmitate.	Dithiothreitol	0-18	kelch-like ECH-associated protein 1	Mus musculus	129-135
28796243-8	2017	1,4-Dithiothreitol, an inhibitor of disulphide bonds, increased the ubiquitylation level of Keap-1, suppressed the expression of Keap-1 and abolished the effects of NaHS on ubiquitin aggregate clearance and ROS production in H9C2 cells treated with high glucose and palmitate.	disulphide	36-46	kelch-like ECH-associated protein 1	Mus musculus	92-98
28796243-8	2017	1,4-Dithiothreitol, an inhibitor of disulphide bonds, increased the ubiquitylation level of Keap-1, suppressed the expression of Keap-1 and abolished the effects of NaHS on ubiquitin aggregate clearance and ROS production in H9C2 cells treated with high glucose and palmitate.	sodium bisulfide	165-169	kelch-like ECH-associated protein 1	Mus musculus	92-98
28796243-8	2017	1,4-Dithiothreitol, an inhibitor of disulphide bonds, increased the ubiquitylation level of Keap-1, suppressed the expression of Keap-1 and abolished the effects of NaHS on ubiquitin aggregate clearance and ROS production in H9C2 cells treated with high glucose and palmitate.	Glucose	254-261	kelch-like ECH-associated protein 1	Mus musculus	92-98
28796243-8	2017	1,4-Dithiothreitol, an inhibitor of disulphide bonds, increased the ubiquitylation level of Keap-1, suppressed the expression of Keap-1 and abolished the effects of NaHS on ubiquitin aggregate clearance and ROS production in H9C2 cells treated with high glucose and palmitate.	Palmitates	266-275	kelch-like ECH-associated protein 1	Mus musculus	92-98
28796243-10	2017	Moreover, exogenous H2S increased Keap-1 expression by suppressing its ubiquitylation, which might have an important role in ubiquitin aggregate clearance via autophagy.	Hydrogen Sulfide	20-23	kelch-like ECH-associated protein 1	Mus musculus	34-40
28903401-0	2017	7-deacetylgedunin suppresses inflammatory responses through activation of Keap1/Nrf2/HO-1 signaling.	Deacetylgedunin	0-17	kelch-like ECH-associated protein 1	Mus musculus	74-79
28903401-10	2017	More importantly, 7-DGD markedly decreased Keap1 expression, promoted p62 expression, and facilitated Nrf2 translocation and localization in the nucleus of macrophages, and in turn up-regulates these anti-oxidant enzymes expression, eventually mediated anti-inflammatory effect.	7-dgd	18-23	kelch-like ECH-associated protein 1	Mus musculus	43-48
28457936-0	2017	Epigallocatechin gallate upregulates NRF2 to prevent diabetic nephropathy via disabling KEAP1.	epigallocatechin gallate	0-24	kelch-like ECH-associated protein 1	Mus musculus	88-93
28562346-8	2017	We found that DSS reduced daily weight gain, suppressed antioxidant enzyme expression, increased histopathology scores and activated NF-kappaB and nuclear factor erythroid 2-related factor 2/Kelch-like ECH-associated protein 1 (Nrf2/Keap1) signaling.	dss	14-17	kelch-like ECH-associated protein 1	Mus musculus	233-238
28419832-8	2017	Analysis of the crosstalk among p62, Keap-1 and Nrf2 demonstrated that the p62 upregulation caused by DMY contributes to a positive feedback loop in Nrf2 activation.	dihydromyricetin	102-105	kelch-like ECH-associated protein 1	Mus musculus	37-43
28457936-12	2017	Other findings indicated that inactivation of KEAP1 protein by EGCG may mediate EGCG function in activating NRF2.	epigallocatechin gallate	63-67	kelch-like ECH-associated protein 1	Mus musculus	46-51
28457936-12	2017	Other findings indicated that inactivation of KEAP1 protein by EGCG may mediate EGCG function in activating NRF2.	epigallocatechin gallate	80-84	kelch-like ECH-associated protein 1	Mus musculus	46-51
28419832-9	2017	In summary, DMY likely modulates p62 and autophagy crosstalk with the Keap-1/Nrf2 pathway to alleviate liver steatosis and the inflammatory response in the pathological progression of ALD.	dihydromyricetin	12-15	kelch-like ECH-associated protein 1	Mus musculus	70-76
28419832-0	2017	Dihydromyricetin modulates p62 and autophagy crosstalk with the Keap-1/Nrf2 pathway to alleviate ethanol-induced hepatic injury.	dihydromyricetin	0-16	kelch-like ECH-associated protein 1	Mus musculus	64-70
28419832-0	2017	Dihydromyricetin modulates p62 and autophagy crosstalk with the Keap-1/Nrf2 pathway to alleviate ethanol-induced hepatic injury.	Ethanol	97-104	kelch-like ECH-associated protein 1	Mus musculus	64-70
28002939-0	2017	Chicoric Acid Ameliorates Lipopolysaccharide-Induced Oxidative Stress via Promoting the Keap1/Nrf2 Transcriptional Signaling Pathway in BV-2 Microglial Cells and Mouse Brain.	chicoric acid	0-13	kelch-like ECH-associated protein 1	Mus musculus	88-93
28419832-6	2017	Notably, DMY remarkably modified aberrant expression of CYP2E1, Keap-1 and HO-1 in the liver and simultaneously ameliorated disordered nuclear localization of NF-kappaB and Nrf2 to exert its hepatoprotective effects.	dihydromyricetin	9-12	kelch-like ECH-associated protein 1	Mus musculus	64-70
28422158-2	2017	The induction of ROS activates the Nrf2-Keap 1 pathway leading to the induction of genes through antioxidant response elements (AREs).	Reactive Oxygen Species	17-20	kelch-like ECH-associated protein 1	Mus musculus	40-46
28033563-6	2017	Moreover, mitoQ restored the expression, activity and translocation of HG-induced NF-E2-related factor 2 (Nrf2) and inhibited the expression of Kelch-like ECH-associated protein (Keap1), as well as the interaction between Nrf2 and Keap1.	mitoquinone	10-15	kelch-like ECH-associated protein 1	Mus musculus	179-184
28033563-6	2017	Moreover, mitoQ restored the expression, activity and translocation of HG-induced NF-E2-related factor 2 (Nrf2) and inhibited the expression of Kelch-like ECH-associated protein (Keap1), as well as the interaction between Nrf2 and Keap1.	mitoquinone	10-15	kelch-like ECH-associated protein 1	Mus musculus	231-236
28467491-4	2017	TBHQ induces phase II detoxification enzymes via the Keap1/Nrf2/ARE mechanism, which contributes to its chemopreventive functions.	2-tert-butylhydroquinone	0-4	kelch-like ECH-associated protein 1	Mus musculus	53-58
28012440-11	2017	The silencing of Keap1, a negative regulator of Nrf2, decreased artesunate sensitivity in HNC cells.	Artesunate	64-74	kelch-like ECH-associated protein 1	Mus musculus	17-22
28012440-12	2017	Nrf2 genetic silencing or trigonelline reversed the ferroptosis resistance of Keap1-silenced and cisplatin-resistant HNC cells to artesunate in vitro and in vivo.	trigonelline	26-38	kelch-like ECH-associated protein 1	Mus musculus	78-83
28012440-12	2017	Nrf2 genetic silencing or trigonelline reversed the ferroptosis resistance of Keap1-silenced and cisplatin-resistant HNC cells to artesunate in vitro and in vivo.	Artesunate	130-140	kelch-like ECH-associated protein 1	Mus musculus	78-83
28213287-5	2017	Butein modulation of Keap1 and Nrf2 as well as HO-1 upregulation was reversed by pretreatment with p38 MAPK inhibitor SB203580, indicating the involvement of p38 MAPK in butein activation of Nrf2 in adipocytes.	SB 203580	118-126	kelch-like ECH-associated protein 1	Mus musculus	21-26
28045693-0	2017	Kelch-like ECH-associated Protein 1-dependent Nuclear Factor-E2-related Factor 2 Activation in Relation to Antioxidation Induced by Sevoflurane Preconditioning.	Sevoflurane	132-143	kelch-like ECH-associated protein 1	Mus musculus	0-35
28045693-11	2017	Sevoflurane preconditioning reduced kelch-like ECH-associated protein 1 expression.	Sevoflurane	0-11	kelch-like ECH-associated protein 1	Mus musculus	36-71
28045693-13	2017	Kelch-like ECH-associated protein 1 overexpression reversed nuclear factor-E2-related factor 2 up-regulation and abolished the neuroprotection induced by sevoflurane preconditioning.	Sevoflurane	154-165	kelch-like ECH-associated protein 1	Mus musculus	0-35
28045693-15	2017	CONCLUSIONS: Kelch-like ECH-associated protein 1 down-regulation-dependent nuclear factor-E2-related factor 2 activation underlies the ability of sevoflurane preconditioning to activate the endogenous antioxidant response, which elicits its neuroprotection.	Sevoflurane	146-157	kelch-like ECH-associated protein 1	Mus musculus	13-48
28157180-0	2017	Toxic metabolites, MAPK and Nrf2/Keap1 signaling pathways involved in oxidative toxicity in mice liver after chronic exposure to Mequindox.	Mequindox	129-138	kelch-like ECH-associated protein 1	Mus musculus	33-38
28157180-8	2017	The present study demonstrated for the first time the protein peroxidation and a proposal metabolic pathway after chronic exposure of MEQ, and illustrated that the MAPK, Nrf2-Keap1 and NF-kB signaling pathways, as well as the altered metabolism of MEQ, were involved in oxidative toxicity mediated by MEQ in vivo.	Mequindox	134-137	kelch-like ECH-associated protein 1	Mus musculus	175-180
28373747-0	2017	Andrographolide Activates Keap1/Nrf2/ARE/HO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by Abeta42 through Nrf2-Related Inflammatory Response.	andrographolide	0-15	kelch-like ECH-associated protein 1	Mus musculus	26-31
27746187-0	2016	Dextran loading protects macrophages from lipid peroxidation and induces a Keap1/Nrf2/ARE-dependent antioxidant response.	Dextrans	0-7	kelch-like ECH-associated protein 1	Mus musculus	75-80
27245349-6	2016	RESULTS: We found that TAK1 upregulated serine 351 phosphorylation of an autophagic adaptor protein, p62/Sequestosome-1 (SQSTM1), which facilitates interaction between p62/SQSTM1 and Keap1 and subsequent Keap1 degradation.	Serine	40-46	kelch-like ECH-associated protein 1	Mus musculus	183-188
27245349-6	2016	RESULTS: We found that TAK1 upregulated serine 351 phosphorylation of an autophagic adaptor protein, p62/Sequestosome-1 (SQSTM1), which facilitates interaction between p62/SQSTM1 and Keap1 and subsequent Keap1 degradation.	Serine	40-46	kelch-like ECH-associated protein 1	Mus musculus	204-209
27904663-9	2016	These beneficial effects of efonipidine were attributed to the increased nuclear expression of nuclear factor-erythroid-2-related factor 2 (Nrf2) on UUO day 3 and the increased expressions of both total and nuclear Nrf2 with elevated Kelch-like ECH-associated protein 1 on UUO day 7.	efonipidine	28-39	kelch-like ECH-associated protein 1	Mus musculus	234-269
27540279-4	2016	Docking results showed that all compounds can potentially interact with Keap1; however, 1,5-dimethyl-2-phenyl-4-(2-phenylquinazolin-4-ylamino)-1,2-dihydropyrazol-3-one (9), the most potent inducer, showed the largest number of interactions with key amino acids in the binding pocket (Arg483, Tyr525, and Phe478) compared to the native ligand or any other compound in this series.	1,5-dimethyl-2-phenyl-4-(2-phenylquinazolin-4-ylamino)-1,2-dihydropyrazol-3-one	88-167	kelch-like ECH-associated protein 1	Mus musculus	72-77
26607633-5	2016	An early increase of Akt and phospho-Erk 1/2 in the cytosol and Nrf2 in the nucleus was also observed, as well as a decrease of cytosolic Keap1caused by QUIN, indicating activation of the Nrf2 pathway mediated by Akt and phospho-Erk 1/2, possibly as a compensatory protective mechanism against the ongoing QUIN-induced toxicity.	Quinolinic Acid	153-157	kelch-like ECH-associated protein 1	Mus musculus	138-143
27759091-7	2016	Finally, we uncovered the underlying mechanism that DADS promoted the endogenous interaction between p21 and Nrf2, which was critical for impairing the Keap1-mediated degradation of Nrf2.	diallyl disulfide	52-56	kelch-like ECH-associated protein 1	Mus musculus	152-157
27335232-0	2016	Hydrogen Sulfide Induces Keap1 S-sulfhydration and Suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 Activation.	Hydrogen Sulfide	0-16	kelch-like ECH-associated protein 1	Mus musculus	25-30
27335232-6	2016	H2S increased S-sulfhydration of Keap1, induced Nrf2 dissociation from Keap1, enhanced Nrf2 nuclear translocation, and inhibited O2 (-) generation, which were abrogated after Keap1 mutated at Cys151, but not Cys273, in endothelial cells.	Hydrogen Sulfide	0-3	kelch-like ECH-associated protein 1	Mus musculus	33-38
27335232-6	2016	H2S increased S-sulfhydration of Keap1, induced Nrf2 dissociation from Keap1, enhanced Nrf2 nuclear translocation, and inhibited O2 (-) generation, which were abrogated after Keap1 mutated at Cys151, but not Cys273, in endothelial cells.	Hydrogen Sulfide	0-3	kelch-like ECH-associated protein 1	Mus musculus	71-76
27335232-6	2016	H2S increased S-sulfhydration of Keap1, induced Nrf2 dissociation from Keap1, enhanced Nrf2 nuclear translocation, and inhibited O2 (-) generation, which were abrogated after Keap1 mutated at Cys151, but not Cys273, in endothelial cells.	Hydrogen Sulfide	0-3	kelch-like ECH-associated protein 1	Mus musculus	71-76
27335232-7	2016	Collectively, H2S attenuates diabetes-accelerated atherosclerosis, which may be related to inhibition of oxidative stress via Keap1 sulfhydrylation at Cys151 to activate Nrf2 signaling.	Hydrogen Sulfide	14-17	kelch-like ECH-associated protein 1	Mus musculus	126-131
27634173-7	2016	We now demonstrate that ezetimibe activates Nrf2-Keap1 pathway which was dependent of autophagy adaptor protein p62, without causing cytotoxicity.	Ezetimibe	24-33	kelch-like ECH-associated protein 1	Mus musculus	49-54
27460172-1	2016	UNLABELLED: Tricyclic, bicyclic, and monocyclic compounds containing cyanoenones induce various anti-inflammatory and cytoprotective enzymes through activation of the Keap1/Nrf2/ARE (antioxidant response element) pathway.	cyanoenones	69-80	kelch-like ECH-associated protein 1	Mus musculus	167-172
27460172-5	2016	Importantly and interestingly, this finding demonstrates that the EA is the essentially important factor that determines the reactivity of the cyanoenones with Keap1.	cyanoenones	143-154	kelch-like ECH-associated protein 1	Mus musculus	160-165
27336362-6	2016	Functional studies show that miR-125b-5p ameliorates ALF by directly regulating kelch-like ECH-associated protein 1, in turn elevating expression of nuclear factor-E2-related factor 2, a known regulator in ALF.	mir-125b-5p	29-40	kelch-like ECH-associated protein 1	Mus musculus	80-115
27470577-8	2016	These findings suggest that Keap1-Nrf2 system plays a key role in depression and that dietary intake of SFN-rich food during juvenile stages and adolescence can confer stress resilience in adulthood.	sulforaphane	104-107	kelch-like ECH-associated protein 1	Mus musculus	28-33
27277809-4	2016	We show that in vitro DMF and MMF activate the Nrf2 pathway via S-alkylation of the Nrf2 inhibitor Keap1 and by causing nuclear exit of the Nrf2 repressor Bach1.	Dimethyl Fumarate	22-25	kelch-like ECH-associated protein 1	Mus musculus	99-104
27277809-4	2016	We show that in vitro DMF and MMF activate the Nrf2 pathway via S-alkylation of the Nrf2 inhibitor Keap1 and by causing nuclear exit of the Nrf2 repressor Bach1.	mmf	30-33	kelch-like ECH-associated protein 1	Mus musculus	99-104
27020858-3	2016	Using Keap1-knockdown (kd) mice, which express high levels of Nrf2, we found that urethane was rapidly excreted into the urine, consistent with an upregulation in the expression of urethane detoxification genes.	Urethane	82-90	kelch-like ECH-associated protein 1	Mus musculus	6-11
27044864-6	2016	In Keap1MuKO mice, muscle glycogen content was strongly reduced and forced GBE expression in C2C12 myotubes promoted glucose uptake.	Glycogen	26-34	kelch-like ECH-associated protein 1	Mus musculus	3-8
27044864-6	2016	In Keap1MuKO mice, muscle glycogen content was strongly reduced and forced GBE expression in C2C12 myotubes promoted glucose uptake.	Glucose	117-124	kelch-like ECH-associated protein 1	Mus musculus	3-8
26096705-0	2016	Sulforaphane Ameliorates 3-Nitropropionic Acid-Induced Striatal Toxicity by Activating the Keap1-Nrf2-ARE Pathway and Inhibiting the MAPKs and NF-kappaB Pathways.	sulforaphane	0-12	kelch-like ECH-associated protein 1	Mus musculus	91-96
26096705-0	2016	Sulforaphane Ameliorates 3-Nitropropionic Acid-Induced Striatal Toxicity by Activating the Keap1-Nrf2-ARE Pathway and Inhibiting the MAPKs and NF-kappaB Pathways.	3-nitropropionic acid	25-46	kelch-like ECH-associated protein 1	Mus musculus	91-96
26096705-8	2016	As expected, the pretreatment with activators (dimethyl fumarate and antioxidant response element inducer-3) of the Keap1-Nrf2-ARE pathway decreased the neurological impairment and lethality after 3-NP treatment.	Dimethyl Fumarate	47-64	kelch-like ECH-associated protein 1	Mus musculus	116-121
26096705-9	2016	Our findings suggest that SFN may effectively attenuate 3-NP-induced striatal toxicity by activating the Keap1-Nrf2-ARE pathway and inhibiting the MAPKs and NF-kappaB pathways and that SFN has a wide therapeutic time-window for HD-like symptoms.	sulforaphane	26-29	kelch-like ECH-associated protein 1	Mus musculus	105-110
27020858-3	2016	Using Keap1-knockdown (kd) mice, which express high levels of Nrf2, we found that urethane was rapidly excreted into the urine, consistent with an upregulation in the expression of urethane detoxification genes.	Urethane	181-189	kelch-like ECH-associated protein 1	Mus musculus	6-11
27020858-4	2016	Consequently, urethane-induced tumors were significantly smaller and less frequent in Keap1-kd mice than in wild-type mice.	Urethane	14-22	kelch-like ECH-associated protein 1	Mus musculus	86-91
26800098-0	2016	Protective effects of pogostone against LPS-induced acute lung injury in mice via regulation of Keap1-Nrf2/NF-kappaB signaling pathways.	Pogostone	22-31	kelch-like ECH-associated protein 1	Mus musculus	96-101
27891208-5	2016	Endogenous n-3 PUFA decreased the elevation of oxidative stress induced by CCl4 challenge, which might be attributed to the activation of Nrf2/keap1 pathway.	Fatty Acids, Omega-3	11-19	kelch-like ECH-associated protein 1	Mus musculus	143-148
26843032-8	2016	Positive Nrf2 and Keap1 immunohistological staining on mouse liver suggested that Nrf2/Keap1 signaling was involved in high salt induced ROS production.	Salts	124-128	kelch-like ECH-associated protein 1	Mus musculus	18-23
26843032-8	2016	Positive Nrf2 and Keap1 immunohistological staining on mouse liver suggested that Nrf2/Keap1 signaling was involved in high salt induced ROS production.	Salts	124-128	kelch-like ECH-associated protein 1	Mus musculus	87-92
26843032-8	2016	Positive Nrf2 and Keap1 immunohistological staining on mouse liver suggested that Nrf2/Keap1 signaling was involved in high salt induced ROS production.	Reactive Oxygen Species	137-140	kelch-like ECH-associated protein 1	Mus musculus	18-23
26843032-8	2016	Positive Nrf2 and Keap1 immunohistological staining on mouse liver suggested that Nrf2/Keap1 signaling was involved in high salt induced ROS production.	Reactive Oxygen Species	137-140	kelch-like ECH-associated protein 1	Mus musculus	87-92
26701603-5	2016	The Keap1-hypo mice were partially protected from obesity, had lower fasting glucose and insulin levels and developed less liver steatosis compared to the wild-type.	Glucose	77-84	kelch-like ECH-associated protein 1	Mus musculus	4-9
26701603-7	2016	Primary Keap1-hypo hepatocyte cultures also show increased Ampk signaling and repressed glucose production.	Glucose	88-95	kelch-like ECH-associated protein 1	Mus musculus	8-13
26698665-4	2016	Strikingly, liver histology revealed a dramatic reduction of lipid droplets confirmed by a decreased content of intra-hepatic triglycerides in Keap1(Deltahepa) compared to controls.	Triglycerides	126-139	kelch-like ECH-associated protein 1	Mus musculus	143-148
26700463-3	2016	The ability of PTS to activate Nrf2 in MIN6 cells was assessed by dissociation of the Nrf2-Keap1 complex at different time points and by expression of ARE-driven downstream target genes of Nrf2.	pterostilbene	15-18	kelch-like ECH-associated protein 1	Mus musculus	91-96
26729554-4	2016	In vitro, bixin was found to activate the NRF2 signaling pathway through blockage of ubiquitylation and degradation of NRF2 in a KEAP1-C151 dependent manner; intraperitoneal (IP) injection of bixin led to pulmonary upregulation of the NRF2 response in vivo.	bixin	10-15	kelch-like ECH-associated protein 1	Mus musculus	129-134
26265043-1	2015	UNLABELLED: The acetylenic tricyclic bis(cyanoenone) TBE-31 is a highly potent cysteine targeting compound with a reversible covalent mode of action; its best-characterized target being Kelch-like ECH-associated protein-1 (Keap1), the cellular sensor for oxidants and electrophiles.	acetylenic tricyclic bis(cyanoenone) tbe	16-56	kelch-like ECH-associated protein 1	Mus musculus	186-221
26459563-3	2015	Here, we describe (3S)-1-[4-[(2,3,5,6-tetramethylphenyl) sulfonylamino]-1-naphthyl]pyrrolidine-3-carboxylic acid (RA839), a small molecule that binds noncovalently to the Nrf2-interacting kelch domain of Keap1 with a Kd of ~6 muM, as demonstrated by x-ray co-crystallization and isothermal titration calorimetry.	(3s)-1-[4-[(2,3,5,6-tetramethylphenyl) sulfonylamino]-1-naphthyl]pyrrolidine	18-94	kelch-like ECH-associated protein 1	Mus musculus	204-209
26459563-3	2015	Here, we describe (3S)-1-[4-[(2,3,5,6-tetramethylphenyl) sulfonylamino]-1-naphthyl]pyrrolidine-3-carboxylic acid (RA839), a small molecule that binds noncovalently to the Nrf2-interacting kelch domain of Keap1 with a Kd of ~6 muM, as demonstrated by x-ray co-crystallization and isothermal titration calorimetry.	3-carboxylic acid	95-112	kelch-like ECH-associated protein 1	Mus musculus	204-209
26459563-3	2015	Here, we describe (3S)-1-[4-[(2,3,5,6-tetramethylphenyl) sulfonylamino]-1-naphthyl]pyrrolidine-3-carboxylic acid (RA839), a small molecule that binds noncovalently to the Nrf2-interacting kelch domain of Keap1 with a Kd of ~6 muM, as demonstrated by x-ray co-crystallization and isothermal titration calorimetry.	RA-839	114-119	kelch-like ECH-associated protein 1	Mus musculus	204-209
26459563-10	2015	RA839 is a selective inhibitor of the Keap1/Nrf2 interaction and a useful tool compound to study the biology of Nrf2.	RA-839	0-5	kelch-like ECH-associated protein 1	Mus musculus	38-43
26527616-0	2016	Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response.	Cysteine	33-41	kelch-like ECH-associated protein 1	Mus musculus	53-58
26527616-2	2016	Although Cys151, Cys273, and Cys288 of Keap1 are major sensor cysteine residues for detecting these stresses, it has not been technically feasible to evaluate the functionality of Cys273 or Cys288, since Keap1 mutants that harbor substitutions in these residues and maintain the ability to repress Nrf2 accumulation do not exist.	Cysteine	62-70	kelch-like ECH-associated protein 1	Mus musculus	39-44
26527616-8	2016	This study thus demonstrates that Keap1 utilizes multiple cysteine residues specifically and/or collaboratively as sensors for the detection of a wide range of environmental stresses.	Cysteine	58-66	kelch-like ECH-associated protein 1	Mus musculus	34-39
26265043-1	2015	UNLABELLED: The acetylenic tricyclic bis(cyanoenone) TBE-31 is a highly potent cysteine targeting compound with a reversible covalent mode of action; its best-characterized target being Kelch-like ECH-associated protein-1 (Keap1), the cellular sensor for oxidants and electrophiles.	acetylenic tricyclic bis(cyanoenone) tbe	16-56	kelch-like ECH-associated protein 1	Mus musculus	223-228
26265043-1	2015	UNLABELLED: The acetylenic tricyclic bis(cyanoenone) TBE-31 is a highly potent cysteine targeting compound with a reversible covalent mode of action; its best-characterized target being Kelch-like ECH-associated protein-1 (Keap1), the cellular sensor for oxidants and electrophiles.	Cysteine	79-87	kelch-like ECH-associated protein 1	Mus musculus	186-221
26265043-1	2015	UNLABELLED: The acetylenic tricyclic bis(cyanoenone) TBE-31 is a highly potent cysteine targeting compound with a reversible covalent mode of action; its best-characterized target being Kelch-like ECH-associated protein-1 (Keap1), the cellular sensor for oxidants and electrophiles.	Cysteine	79-87	kelch-like ECH-associated protein 1	Mus musculus	223-228
26265043-2	2015	TBE-31 reacts with cysteines of Keap1, impairing its ability to target nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) for degradation.	tbe	0-3	kelch-like ECH-associated protein 1	Mus musculus	32-37
26265043-2	2015	TBE-31 reacts with cysteines of Keap1, impairing its ability to target nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) for degradation.	Cysteine	19-28	kelch-like ECH-associated protein 1	Mus musculus	32-37
25818184-0	2015	The role of 17beta-estradiol in the regulation of antioxidant enzymes via the Nrf2-Keap1 pathway in the livers of CBA/H mice.	Estradiol	12-28	kelch-like ECH-associated protein 1	Mus musculus	83-88
25816687-6	2015	TauCl binds directly to Kelch-like ECH association protein 1 (Keap1), which appears to retard the Keap1-driven degradation of Nrf2.	N-chlorotaurine	0-5	kelch-like ECH-associated protein 1	Mus musculus	24-60
25816687-6	2015	TauCl binds directly to Kelch-like ECH association protein 1 (Keap1), which appears to retard the Keap1-driven degradation of Nrf2.	N-chlorotaurine	0-5	kelch-like ECH-associated protein 1	Mus musculus	62-67
25816687-6	2015	TauCl binds directly to Kelch-like ECH association protein 1 (Keap1), which appears to retard the Keap1-driven degradation of Nrf2.	N-chlorotaurine	0-5	kelch-like ECH-associated protein 1	Mus musculus	98-103
25896849-5	2015	Mutation of cysteine to serine of keap-1 proteins (C151S, C273S, and C288S) lost the ability of HO-1 induction by AscA, due to failure of translocation of Nrf-2 to nucleus.	Cysteine	12-20	kelch-like ECH-associated protein 1	Mus musculus	34-40
25896849-5	2015	Mutation of cysteine to serine of keap-1 proteins (C151S, C273S, and C288S) lost the ability of HO-1 induction by AscA, due to failure of translocation of Nrf-2 to nucleus.	Serine	24-30	kelch-like ECH-associated protein 1	Mus musculus	34-40
26111761-6	2015	Farrerol down-regulated the expression of the Keap1 protein and the thiol reducing agents attenuated farrerol-induced HO-1 expression.	farrerol	0-8	kelch-like ECH-associated protein 1	Mus musculus	46-51
26111761-6	2015	Farrerol down-regulated the expression of the Keap1 protein and the thiol reducing agents attenuated farrerol-induced HO-1 expression.	farrerol	101-109	kelch-like ECH-associated protein 1	Mus musculus	46-51
26111761-9	2015	It is hence likely that farrerol inactivated KEAP-1 or activated the Akt, p38 and ERK to facilitate the release of Nrf2 from Keap1 and subsequent reduced the intracellular production of reactive oxygen species via the induction of HO-1 expression.	farrerol	24-32	kelch-like ECH-associated protein 1	Mus musculus	45-51
26111761-9	2015	It is hence likely that farrerol inactivated KEAP-1 or activated the Akt, p38 and ERK to facilitate the release of Nrf2 from Keap1 and subsequent reduced the intracellular production of reactive oxygen species via the induction of HO-1 expression.	farrerol	24-32	kelch-like ECH-associated protein 1	Mus musculus	125-130
26551704-6	2015	The proximal regulator of Nrf2 is Keap1 (Kelch-like ECH-associated protein-1), a cysteine (Cys)-rich protein that normally interacts transiently with Nrf2, targeting it for degradation.	Cysteine	81-89	kelch-like ECH-associated protein 1	Mus musculus	34-39
26551704-6	2015	The proximal regulator of Nrf2 is Keap1 (Kelch-like ECH-associated protein-1), a cysteine (Cys)-rich protein that normally interacts transiently with Nrf2, targeting it for degradation.	Cysteine	81-89	kelch-like ECH-associated protein 1	Mus musculus	41-76
26551704-6	2015	The proximal regulator of Nrf2 is Keap1 (Kelch-like ECH-associated protein-1), a cysteine (Cys)-rich protein that normally interacts transiently with Nrf2, targeting it for degradation.	Cysteine	91-94	kelch-like ECH-associated protein 1	Mus musculus	34-39
26551704-6	2015	The proximal regulator of Nrf2 is Keap1 (Kelch-like ECH-associated protein-1), a cysteine (Cys)-rich protein that normally interacts transiently with Nrf2, targeting it for degradation.	Cysteine	91-94	kelch-like ECH-associated protein 1	Mus musculus	41-76
25818184-1	2015	AIMS: We aimed to explore the impact of surgical 17beta-estradiol (E2) deprivation/administration on the expression of antioxidant enzymes with an emphasis on the alteration of the NF-E2-related factor 2/Kelch-like ECH-associated protein 1 (Nrf2/Keap1) pathway under physiological conditions in the livers of CBA/H mice of both sexes.	Estradiol	49-65	kelch-like ECH-associated protein 1	Mus musculus	246-251
25818184-1	2015	AIMS: We aimed to explore the impact of surgical 17beta-estradiol (E2) deprivation/administration on the expression of antioxidant enzymes with an emphasis on the alteration of the NF-E2-related factor 2/Kelch-like ECH-associated protein 1 (Nrf2/Keap1) pathway under physiological conditions in the livers of CBA/H mice of both sexes.	Estradiol	67-69	kelch-like ECH-associated protein 1	Mus musculus	246-251
25586622-10	2015	Furthermore, expressions of the hepatic Nrf2 protein and Nrf2, Keap1, and NQO1 genes in the HT + Zn group were not only higher than the HT group but also higher than the control group.	Zinc	97-99	kelch-like ECH-associated protein 1	Mus musculus	63-68
25288107-0	2015	Melatonin antagonizes Mn-induced oxidative injury through the activation of keap1-Nrf2-ARE signaling pathway in the striatum of mice.	Melatonin	0-9	kelch-like ECH-associated protein 1	Mus musculus	76-81
25906049-0	2015	Differential in vivo genotoxicity of arsenic trioxide in glutathione depleted mouse bone marrow cells: expressions of Nrf2/Keap1/P62.	Arsenic Trioxide	37-53	kelch-like ECH-associated protein 1	Mus musculus	123-128
25288107-4	2015	This study investigated the role of melatonin (MLT), an agent that was recently shown to induce the activation of the Kelch-like ECH-associated protein 1 (Keap1)-Nrf2-antioxidant response elements (ARE) pathway against manganism.	Melatonin	36-45	kelch-like ECH-associated protein 1	Mus musculus	118-153
25288107-4	2015	This study investigated the role of melatonin (MLT), an agent that was recently shown to induce the activation of the Kelch-like ECH-associated protein 1 (Keap1)-Nrf2-antioxidant response elements (ARE) pathway against manganism.	Melatonin	36-45	kelch-like ECH-associated protein 1	Mus musculus	155-160
25421510-7	2014	In parallel, alcohol exposure in vitro decreased Keap1 gene and protein expression in lung fibroblasts.	Alcohols	13-20	kelch-like ECH-associated protein 1	Mus musculus	49-54
25280775-4	2015	Phalloidin increased the expression of neutrophil-specific chemokine mKC and MIP-2 in Nrf2-null and WT mice, but such increases were attenuated in Keap1-HKO and OA-pretreated mice.	Phalloidine	0-10	kelch-like ECH-associated protein 1	Mus musculus	147-152
26310178-10	2015	8-Nitro-cGMP specifically S-guanylates Keap1, a negative regulator of transcription factor Nrf2, which in turn up-regulates transcription of HO-1.	8-nitroguanosine 3',5'-cyclic monophosphate	0-12	kelch-like ECH-associated protein 1	Mus musculus	39-44
26576227-4	2015	Additionally, Lico A dramatically upregulated the antioxidant enzyme heme oxygenase 1 (HO-1) and nuclear factor erythroid 2-related factor 2 (Nrf2), which were associated with inducing Nrf2 nuclear translocation, decreasing Keap1 protein expression and increasing antioxidant response element (ARE) promoter activity.	licochalcone A	14-20	kelch-like ECH-associated protein 1	Mus musculus	224-229
25270507-5	2014	Nrf2 induction by genetic knockdown of Keap1 increased plasma FGF21 level and hepatic Fgf21 expression in diabetic db/db mice and high-calorie-diet-induced obesity model mice.	calorie	135-142	kelch-like ECH-associated protein 1	Mus musculus	39-44
24406247-0	2014	1,4-Naphthoquinone, a pro-oxidant, suppresses immune responses via KEAP-1 glutathionylation.	1,4-naphthoquinone	0-18	kelch-like ECH-associated protein 1	Mus musculus	67-73
25002747-10	2014	These results demonstrated that dynamic and coordinated regulation of KEAP1-NRF2-ARE and p53/p21 signaling pathways was associated with compensatory liver regeneration after APAP-induced acute liver injury.	Acetaminophen	174-178	kelch-like ECH-associated protein 1	Mus musculus	70-75
24859727-10	2014	Only two proteins altered by CDDO-me in WT animals were similarly affected in Nrf2((-/-)) mice, demonstrating the high degree of selectivity of CDDO-me for the Nrf2:Keap1 signalling pathway.	bardoxolone methyl	144-151	kelch-like ECH-associated protein 1	Mus musculus	165-170
24769730-5	2014	Here we demonstrate that Keap1 protein was rapidly degraded in hepatocytes, through autophagy in a p62-dependent manner, in response to the toxic saturated FFA palmitate, but not following incubation with the non-toxic FFA oleic acid.	Fatty Acids, Nonesterified	156-159	kelch-like ECH-associated protein 1	Mus musculus	25-30
24769730-5	2014	Here we demonstrate that Keap1 protein was rapidly degraded in hepatocytes, through autophagy in a p62-dependent manner, in response to the toxic saturated FFA palmitate, but not following incubation with the non-toxic FFA oleic acid.	Palmitates	160-169	kelch-like ECH-associated protein 1	Mus musculus	25-30
24769730-5	2014	Here we demonstrate that Keap1 protein was rapidly degraded in hepatocytes, through autophagy in a p62-dependent manner, in response to the toxic saturated FFA palmitate, but not following incubation with the non-toxic FFA oleic acid.	Fatty Acids, Nonesterified	219-222	kelch-like ECH-associated protein 1	Mus musculus	25-30
24769730-5	2014	Here we demonstrate that Keap1 protein was rapidly degraded in hepatocytes, through autophagy in a p62-dependent manner, in response to the toxic saturated FFA palmitate, but not following incubation with the non-toxic FFA oleic acid.	Oleic Acid	223-233	kelch-like ECH-associated protein 1	Mus musculus	25-30
24769730-7	2014	Also, Keap1 knockdown further sensitized hepatocytes to lipoapoptosis by palmitate.	Palmitates	73-82	kelch-like ECH-associated protein 1	Mus musculus	6-11
24769730-8	2014	Likewise, primary hepatocytes isolated from liver-specific Keap1(-/-) mice displayed higher Bim and PUMA protein levels and demonstrated increased sensitivity to palmitate-induced apoptosis than wild-type mouse hepatocytes.	Palmitates	162-171	kelch-like ECH-associated protein 1	Mus musculus	59-64
24556415-0	2014	Oxaliplatin activates the Keap1/Nrf2 antioxidant system conferring protection against the cytotoxicity of anticancer drugs.	Oxaliplatin	0-11	kelch-like ECH-associated protein 1	Mus musculus	26-31
24556415-6	2014	However, forced expression of WT mKeap1 restored the ability of oxaliplatin to activate the transcription factor.	Oxaliplatin	64-75	kelch-like ECH-associated protein 1	Mus musculus	33-39
24556415-7	2014	Cys(151) in Keap1 was required for the response stimulated by oxaliplatin.	Cysteine	0-3	kelch-like ECH-associated protein 1	Mus musculus	12-17
24556415-7	2014	Cys(151) in Keap1 was required for the response stimulated by oxaliplatin.	Oxaliplatin	62-73	kelch-like ECH-associated protein 1	Mus musculus	12-17
24406247-8	2014	NQ treatment increased total protein S-thiolation, induced glutathionylation of KEAP-1 protein and decreased IKKbeta levels in lymphocytes.	1,4-naphthoquinone	0-2	kelch-like ECH-associated protein 1	Mus musculus	80-86
24406247-9	2014	Molecular docking studies revealed that NQ can disrupt KEAP-1/Nrf-2 interaction by directly blocking the binding site of Nrf-2 in the KEAP-1 protein.	1,4-naphthoquinone	40-42	kelch-like ECH-associated protein 1	Mus musculus	55-61
24406247-9	2014	Molecular docking studies revealed that NQ can disrupt KEAP-1/Nrf-2 interaction by directly blocking the binding site of Nrf-2 in the KEAP-1 protein.	1,4-naphthoquinone	40-42	kelch-like ECH-associated protein 1	Mus musculus	134-140
25270507-7	2014	Furthermore, in Keap1-knockdown db/db mice, Nrf2 enhanced expression of glucose- and lipid-metabolism-related genes in adipose tissues, which improved plasma lipid profiles.	Glucose	72-79	kelch-like ECH-associated protein 1	Mus musculus	16-21
24675710-8	2014	alpha-DHC targeted Keap-1 by modifying its cysteine thiols, dissociating it from Nrf-2 and facilitating nuclear entry of the latter; and this in turn induced HO-1 expression.	alpha-dhc	0-9	kelch-like ECH-associated protein 1	Mus musculus	19-25
24675710-8	2014	alpha-DHC targeted Keap-1 by modifying its cysteine thiols, dissociating it from Nrf-2 and facilitating nuclear entry of the latter; and this in turn induced HO-1 expression.	cysteine thiols	43-58	kelch-like ECH-associated protein 1	Mus musculus	19-25
24675710-9	2014	Thus alpha-DHC exerts its anti-inflammatory activity in a dual manner: by down regulating MAPKs and restricting nuclear stabilization of NF-kappaB at one end, and by disrupting Nrf-2-Keap-1 complex on the other.	alpha-dhc	5-14	kelch-like ECH-associated protein 1	Mus musculus	183-189
24530882-10	2014	Furthermore, the expression of Nrf2 was reduced, and its repressor Kelch-like ECH-associated protein 1 (Keap1) was increased significantly, whereas heme oxygenase-1 (HO-1) was upregulated and NAD(P)H quinone oxidoreductase-1 (NQO1) was barely increased in the cytoplasm of tubules in kidneys after treatment with AAI.	aristolochic acid I	313-316	kelch-like ECH-associated protein 1	Mus musculus	67-102
24530882-10	2014	Furthermore, the expression of Nrf2 was reduced, and its repressor Kelch-like ECH-associated protein 1 (Keap1) was increased significantly, whereas heme oxygenase-1 (HO-1) was upregulated and NAD(P)H quinone oxidoreductase-1 (NQO1) was barely increased in the cytoplasm of tubules in kidneys after treatment with AAI.	aristolochic acid I	313-316	kelch-like ECH-associated protein 1	Mus musculus	104-109
24667526-10	2014	The mRNAs of GSH conjugation and peroxide reduction enzymes, such as Gstalpha1, Gstalpha4, Gstmu, and Gpx2 were higher in livers of Keap1-HKO mice, together with higher expression of the rate-limiting enzyme for GSH synthesis (Gclc).	Glutathione	13-16	kelch-like ECH-associated protein 1	Mus musculus	132-137
24667526-10	2014	The mRNAs of GSH conjugation and peroxide reduction enzymes, such as Gstalpha1, Gstalpha4, Gstmu, and Gpx2 were higher in livers of Keap1-HKO mice, together with higher expression of the rate-limiting enzyme for GSH synthesis (Gclc).	Peroxides	33-41	kelch-like ECH-associated protein 1	Mus musculus	132-137
24667526-10	2014	The mRNAs of GSH conjugation and peroxide reduction enzymes, such as Gstalpha1, Gstalpha4, Gstmu, and Gpx2 were higher in livers of Keap1-HKO mice, together with higher expression of the rate-limiting enzyme for GSH synthesis (Gclc).	Glutathione	212-215	kelch-like ECH-associated protein 1	Mus musculus	132-137
24667526-12	2014	In conclusion, this study demonstrates that higher basal levels of Nrf2 and GSH-related genes in Keap1-HKO mice prevented microcystin-induced oxidative stress and liver injury.	Glutathione	76-79	kelch-like ECH-associated protein 1	Mus musculus	97-102
24206218-8	2014	In the absence of glucose, addition of fatty acids differentially affects the production of ATP in mouse embryonic fibroblasts from wild-type, Nrf2-knockout and Keap1 (Kelch-like ECH-associated protein 1)-knockout mice.	Fatty Acids	39-50	kelch-like ECH-associated protein 1	Mus musculus	161-166
24206218-8	2014	In the absence of glucose, addition of fatty acids differentially affects the production of ATP in mouse embryonic fibroblasts from wild-type, Nrf2-knockout and Keap1 (Kelch-like ECH-associated protein 1)-knockout mice.	Fatty Acids	39-50	kelch-like ECH-associated protein 1	Mus musculus	168-203
24206218-8	2014	In the absence of glucose, addition of fatty acids differentially affects the production of ATP in mouse embryonic fibroblasts from wild-type, Nrf2-knockout and Keap1 (Kelch-like ECH-associated protein 1)-knockout mice.	Adenosine Triphosphate	92-95	kelch-like ECH-associated protein 1	Mus musculus	161-166
24206218-8	2014	In the absence of glucose, addition of fatty acids differentially affects the production of ATP in mouse embryonic fibroblasts from wild-type, Nrf2-knockout and Keap1 (Kelch-like ECH-associated protein 1)-knockout mice.	Adenosine Triphosphate	92-95	kelch-like ECH-associated protein 1	Mus musculus	168-203
24489685-0	2014	Keap1 cysteine 288 as a potential target for diallyl trisulfide-induced Nrf2 activation.	Cysteine	6-14	kelch-like ECH-associated protein 1	Mus musculus	0-5
24216314-8	2014	Induction of Nrf2 signaling in response to sodium iodate was partially restored in the RPE of aging mice with genetic rescue, using conditional knockdown of the Nrf2 negative regulator Keap1 (Tam-Cre; Keap1loxP) compared to Keap1loxP mice.	sodium iodate	43-56	kelch-like ECH-associated protein 1	Mus musculus	185-190
24161443-4	2014	MiR-200a-3p/141-3p, in turn, act to target Keap1, Tgfbeta2, fibronectin, and Zeb2 directly and regulate Tgfbeta1 and Nrf2 indirectly under high-glucose conditions, resulting in profound dysregulations in Keap1-Nrf2, Tgfbeta1/2, and Zeb1/2 signaling.	Glucose	144-151	kelch-like ECH-associated protein 1	Mus musculus	43-48
24489685-8	2014	Cysteine-151, -273 and -288 of Kelch-like ECH-associated protein-1 (Keap1), a cytosolic repressor of Nrf2, have been considered to act as a redox sensor and play a role in Nrf2 activation.	Cysteine	0-8	kelch-like ECH-associated protein 1	Mus musculus	31-66
24489685-8	2014	Cysteine-151, -273 and -288 of Kelch-like ECH-associated protein-1 (Keap1), a cytosolic repressor of Nrf2, have been considered to act as a redox sensor and play a role in Nrf2 activation.	Cysteine	0-8	kelch-like ECH-associated protein 1	Mus musculus	68-73
24489685-0	2014	Keap1 cysteine 288 as a potential target for diallyl trisulfide-induced Nrf2 activation.	diallyl trisulfide	45-63	kelch-like ECH-associated protein 1	Mus musculus	0-5
23801334-0	2013	The Keap1/Nrf2 protein axis plays a role in osteoclast differentiation by regulating intracellular reactive oxygen species signaling.	Reactive Oxygen Species	99-122	kelch-like ECH-associated protein 1	Mus musculus	4-9
24489685-11	2014	LC-ESI-MS/MS analysis of recombinant Keap1 treated with DATS revealed that the peptide fragment containing Cys288 gained a molecular mass of 72.1 Da equivalent to the molecular weight of mono-allyl mono-sulfide.	dats	56-60	kelch-like ECH-associated protein 1	Mus musculus	37-42
24489685-11	2014	LC-ESI-MS/MS analysis of recombinant Keap1 treated with DATS revealed that the peptide fragment containing Cys288 gained a molecular mass of 72.1 Da equivalent to the molecular weight of mono-allyl mono-sulfide.	mono-allyl mono-sulfide	187-210	kelch-like ECH-associated protein 1	Mus musculus	37-42
24489685-12	2014	Taken together, these findings suggest that DATS may directly interact with the Cys288 residue of Keap1, which partly accounts for its ability to induce Nrf2 activation and upregulate defensive gene expression.	dats	44-48	kelch-like ECH-associated protein 1	Mus musculus	98-103
24191056-3	2013	A striking feature of the structure of exemestane is an extended system of conjugated Michael reaction functions, which is also characteristic of inducers of a broad network of chemoprotective genes regulated by the Keap1 (Kelch-like ECA-associated protein)/Nrf2 (nuclear factor E2-related factor 2)/ARE (antioxidant response element) signaling system.	exemestane	39-49	kelch-like ECH-associated protein 1	Mus musculus	216-221
24224011-0	2013	Keap1-knockdown decreases fasting-induced fatty liver via altered lipid metabolism and decreased fatty acid mobilization from adipose tissue.	Fatty Acids	97-107	kelch-like ECH-associated protein 1	Mus musculus	0-5
24055470-4	2013	We demonstrated that polysulfide reversibly modified Keap1 to form oxidized dimers and induced the translocation of Nrf2.	polysulfide	21-32	kelch-like ECH-associated protein 1	Mus musculus	53-58
24131734-9	2013	Acrolein exposure rapidly depleted lung tissue glutathione (GSH) levels, and induced activation of the Nrf2 pathway, indicated by accumulation of Nrf2, increased alkylation of Keap1, and induction of Nrf2-target genes such as HO-1.	Acrolein	0-8	kelch-like ECH-associated protein 1	Mus musculus	176-181
23157314-3	2013	For example, it can react with particular protein Cys thiols because of its electrophilicity and can cause unique post-translational modifications of redox-sensor proteins such as Keap1 and H-Ras.	Cysteine	50-53	kelch-like ECH-associated protein 1	Mus musculus	180-185
23157314-3	2013	For example, it can react with particular protein Cys thiols because of its electrophilicity and can cause unique post-translational modifications of redox-sensor proteins such as Keap1 and H-Ras.	Sulfhydryl Compounds	54-60	kelch-like ECH-associated protein 1	Mus musculus	180-185
23157314-4	2013	CRITICAL ISSUES: Site-specific S-guanylation of Keap1 at Cys434 induced NO- and ROS-mediated adaptive responses to oxidative stress.	Reactive Oxygen Species	80-83	kelch-like ECH-associated protein 1	Mus musculus	48-53
23800876-8	2013	Co-immunoprecipitation experiments revealed that, in addition to AhR-Arnt binding, TCDD induced an interaction between AhR and Nrf2 as well as Keap1.	Polychlorinated Dibenzodioxins	83-87	kelch-like ECH-associated protein 1	Mus musculus	143-148
23884569-7	2013	RESULTS: CR lowered hepatic lipid content, and induced fatty acid oxidation gene expression to a greater degree in Keap1-KD compared to C57BL/6 mice.	Fatty Acids	55-65	kelch-like ECH-associated protein 1	Mus musculus	115-120
23884569-8	2013	CR differentially altered miRNA 34a, 370, let-7b* in livers of Keap1-KD compared to C57BL/6 mice.	Chromium	0-2	kelch-like ECH-associated protein 1	Mus musculus	63-68
23884569-9	2013	CONCLUSIONS: CR induced induction of fatty acid oxidation gene expression was augmented with Keap1 knockdown, which was associated with differential expression of several miRNAs implicated in fatty acid oxidation and lipid accumulation.	Chromium	13-15	kelch-like ECH-associated protein 1	Mus musculus	93-98
23884569-9	2013	CONCLUSIONS: CR induced induction of fatty acid oxidation gene expression was augmented with Keap1 knockdown, which was associated with differential expression of several miRNAs implicated in fatty acid oxidation and lipid accumulation.	Fatty Acids	192-202	kelch-like ECH-associated protein 1	Mus musculus	93-98
23801334-9	2013	This is the first study to show that the Keap1/Nrf2 axis regulates RANKL-dependent osteoclastogenesis through modulation of intracellular ROS signaling via expression of cytoprotective enzymes.	Reactive Oxygen Species	138-141	kelch-like ECH-associated protein 1	Mus musculus	41-46
23867319-1	2013	BACKGROUND &amp; AIMS: The Keap1-Nrf2 signaling pathway regulates host cell defense responses against oxidative stress and maintains the cellular redox balance.	Adenosine Monophosphate	12-15	kelch-like ECH-associated protein 1	Mus musculus	27-32
23867319-7	2013	Pretreatment of liver donors with PI3K inhibitor (LY294002) disrupted Akt/HIF-1A signaling and recreated hepatocellular damage in otherwise IR-resistant Keap1 HKO transplants.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	kelch-like ECH-associated protein 1	Mus musculus	153-158
24018193-0	2013	Synthesis and biological evaluation of biotin conjugates of (+-)-(4bS,8aR,10aS)-10a-ethynyl-4b,8,8-trimethyl-3,7-dioxo-3,4b,7,8,8a,9,10,10a-octahydro-phenanthrene-2,6-dicarbonitrile, an activator of the Keap1/Nrf2/ARE pathway, for the isolation of its protein targets.	Biotin	39-45	kelch-like ECH-associated protein 1	Mus musculus	203-208
22688683-0	2013	1H, 15N and 13C backbone resonance assignments of the Kelch domain of mouse Keap1.	Hydrogen	0-2	kelch-like ECH-associated protein 1	Mus musculus	76-81
22688683-0	2013	1H, 15N and 13C backbone resonance assignments of the Kelch domain of mouse Keap1.	15n	4-7	kelch-like ECH-associated protein 1	Mus musculus	76-81
22688683-0	2013	1H, 15N and 13C backbone resonance assignments of the Kelch domain of mouse Keap1.	13c	12-15	kelch-like ECH-associated protein 1	Mus musculus	76-81
23825090-4	2013	METHODS: Sulforaphane [SF, 1-isothiocyano-4-(methylsulfinyl)butane] derived from its glucosinolate precursor contained in cruciferous vegetables and related inducers of the Keap1/Nrf2/ARE pathway were assessed for their potencies to induce ALDH in murine hepatoma Hepa1c1c7 cells.	sulforaphane	9-21	kelch-like ECH-associated protein 1	Mus musculus	173-178
23825090-4	2013	METHODS: Sulforaphane [SF, 1-isothiocyano-4-(methylsulfinyl)butane] derived from its glucosinolate precursor contained in cruciferous vegetables and related inducers of the Keap1/Nrf2/ARE pathway were assessed for their potencies to induce ALDH in murine hepatoma Hepa1c1c7 cells.	sulforaphane	23-25	kelch-like ECH-associated protein 1	Mus musculus	173-178
23825090-4	2013	METHODS: Sulforaphane [SF, 1-isothiocyano-4-(methylsulfinyl)butane] derived from its glucosinolate precursor contained in cruciferous vegetables and related inducers of the Keap1/Nrf2/ARE pathway were assessed for their potencies to induce ALDH in murine hepatoma Hepa1c1c7 cells.	Glucosinolates	85-98	kelch-like ECH-associated protein 1	Mus musculus	173-178
23884569-3	2013	However, limited interaction of Nrf2/Keap1 and CR exists.	Chromium	47-49	kelch-like ECH-associated protein 1	Mus musculus	37-42
23884569-4	2013	The purpose of this study was to determine how Keap1 knockdown (Keap1-KD), which is known to increase Nrf2 activity, affects the CR response, such as weight loss, hepatic lipid decrease, and induction of fatty acid oxidation gene expression.	Chromium	129-131	kelch-like ECH-associated protein 1	Mus musculus	47-52
23884569-4	2013	The purpose of this study was to determine how Keap1 knockdown (Keap1-KD), which is known to increase Nrf2 activity, affects the CR response, such as weight loss, hepatic lipid decrease, and induction of fatty acid oxidation gene expression.	Chromium	129-131	kelch-like ECH-associated protein 1	Mus musculus	64-69
23884569-4	2013	The purpose of this study was to determine how Keap1 knockdown (Keap1-KD), which is known to increase Nrf2 activity, affects the CR response, such as weight loss, hepatic lipid decrease, and induction of fatty acid oxidation gene expression.	Fatty Acids	204-214	kelch-like ECH-associated protein 1	Mus musculus	47-52
23884569-4	2013	The purpose of this study was to determine how Keap1 knockdown (Keap1-KD), which is known to increase Nrf2 activity, affects the CR response, such as weight loss, hepatic lipid decrease, and induction of fatty acid oxidation gene expression.	Fatty Acids	204-214	kelch-like ECH-associated protein 1	Mus musculus	64-69
23884569-7	2013	RESULTS: CR lowered hepatic lipid content, and induced fatty acid oxidation gene expression to a greater degree in Keap1-KD compared to C57BL/6 mice.	Chromium	9-11	kelch-like ECH-associated protein 1	Mus musculus	115-120
22964642-9	2013	Pre-treatment of Keap1(-/-) MEFs or A549 cells with the LY294002 PI3K inhibitor or the MK-2206 PKB/Akt inhibitor increased their sensitivity to acrolein, chlorambucil and cisplatin between 1.9-fold and 3.1-fold, and this was substantially attenuated by simultaneous pre-treatment with the GSK-3 inhibitor CT99021.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	kelch-like ECH-associated protein 1	Mus musculus	17-22
22964642-9	2013	Pre-treatment of Keap1(-/-) MEFs or A549 cells with the LY294002 PI3K inhibitor or the MK-2206 PKB/Akt inhibitor increased their sensitivity to acrolein, chlorambucil and cisplatin between 1.9-fold and 3.1-fold, and this was substantially attenuated by simultaneous pre-treatment with the GSK-3 inhibitor CT99021.	MK 2206	87-94	kelch-like ECH-associated protein 1	Mus musculus	17-22
22964642-9	2013	Pre-treatment of Keap1(-/-) MEFs or A549 cells with the LY294002 PI3K inhibitor or the MK-2206 PKB/Akt inhibitor increased their sensitivity to acrolein, chlorambucil and cisplatin between 1.9-fold and 3.1-fold, and this was substantially attenuated by simultaneous pre-treatment with the GSK-3 inhibitor CT99021.	Acrolein	144-152	kelch-like ECH-associated protein 1	Mus musculus	17-22
22964642-9	2013	Pre-treatment of Keap1(-/-) MEFs or A549 cells with the LY294002 PI3K inhibitor or the MK-2206 PKB/Akt inhibitor increased their sensitivity to acrolein, chlorambucil and cisplatin between 1.9-fold and 3.1-fold, and this was substantially attenuated by simultaneous pre-treatment with the GSK-3 inhibitor CT99021.	Chlorambucil	154-166	kelch-like ECH-associated protein 1	Mus musculus	17-22
22964642-9	2013	Pre-treatment of Keap1(-/-) MEFs or A549 cells with the LY294002 PI3K inhibitor or the MK-2206 PKB/Akt inhibitor increased their sensitivity to acrolein, chlorambucil and cisplatin between 1.9-fold and 3.1-fold, and this was substantially attenuated by simultaneous pre-treatment with the GSK-3 inhibitor CT99021.	Cisplatin	171-180	kelch-like ECH-associated protein 1	Mus musculus	17-22
23716596-5	2013	When Keap1flox/- mice were crossed with diabetic db/db mice, blood glucose levels became lower through improvement of both insulin secretion and insulin resistance.	Blood Glucose	61-74	kelch-like ECH-associated protein 1	Mus musculus	5-10
23674500-0	2013	KEAP1 is a redox sensitive target that arbitrates the opposing radiosensitive effects of parthenolide in normal and cancer cells.	parthenolide	89-101	kelch-like ECH-associated protein 1	Mus musculus	0-5
23674500-4	2013	The present study identifies KEAP1 as the downstream redox target that contributes to parthenolide"s radiosensitization effect in prostate cancer cells.	parthenolide	86-98	kelch-like ECH-associated protein 1	Mus musculus	29-34
23674500-6	2013	Mechanistically, parthenolide increases the level of cellular ROS and causes oxidation of thioredoxin (TrX) in prostate cancer cells, leading to a TrX-dependent increase in a reduced state of KEAP1, which in turn leads to KEAP1-mediated PGAM5 and Bcl-xL (BCL2L1) degradation.	parthenolide	17-29	kelch-like ECH-associated protein 1	Mus musculus	192-197
23674500-6	2013	Mechanistically, parthenolide increases the level of cellular ROS and causes oxidation of thioredoxin (TrX) in prostate cancer cells, leading to a TrX-dependent increase in a reduced state of KEAP1, which in turn leads to KEAP1-mediated PGAM5 and Bcl-xL (BCL2L1) degradation.	parthenolide	17-29	kelch-like ECH-associated protein 1	Mus musculus	222-227
23674500-7	2013	In contrast, parthenolide increases oxidation of KEAP1 in normal prostate epithelial cells, leading to increased Nrf2 (NFE2L2) levels and subsequent Nrf2-dependent expression of antioxidant enzymes.	parthenolide	13-25	kelch-like ECH-associated protein 1	Mus musculus	49-54
23674500-8	2013	These results reveal a novel redox-mediated modification of KEAP1 in controlling the differential effect of parthenolide on tumor and normal cell radiosensitivity.	parthenolide	108-120	kelch-like ECH-associated protein 1	Mus musculus	60-65
27335833-0	2013	In Vivo Effect of Arsenic Trioxide on Keap1-p62-Nrf2 Signaling Pathway in Mouse Liver: Expression of Antioxidant Responsive Element-Driven Genes Related to Glutathione Metabolism.	Arsenic Trioxide	18-34	kelch-like ECH-associated protein 1	Mus musculus	38-43
27335833-8	2013	Keap1 protein as well as mRNA level decreased concomitantly in arsenic treated mice.	Arsenic	63-70	kelch-like ECH-associated protein 1	Mus musculus	0-5
23295186-0	2013	Protective effect of lipoic acid against oxidative stress is mediated by Keap1/Nrf2-dependent heme oxygenase-1 induction in the RGC-5 cellline.	Thioctic Acid	21-32	kelch-like ECH-associated protein 1	Mus musculus	73-78
23718696-1	2013	2-tert-Butyl-1,4-benzoquinone (TBQ), an electrophilic metabolite of butylated hydroxyanisole (BHA), causes activation of Nrf2 together with S-arylation of its negative regulator Keap1 in RAW264.7 cells.	2-tert-butyl-4-quinone	0-29	kelch-like ECH-associated protein 1	Mus musculus	178-183
23718696-1	2013	2-tert-Butyl-1,4-benzoquinone (TBQ), an electrophilic metabolite of butylated hydroxyanisole (BHA), causes activation of Nrf2 together with S-arylation of its negative regulator Keap1 in RAW264.7 cells.	2-tert-butyl-4-quinone	31-34	kelch-like ECH-associated protein 1	Mus musculus	178-183
23718696-1	2013	2-tert-Butyl-1,4-benzoquinone (TBQ), an electrophilic metabolite of butylated hydroxyanisole (BHA), causes activation of Nrf2 together with S-arylation of its negative regulator Keap1 in RAW264.7 cells.	Butylated Hydroxyanisole	68-92	kelch-like ECH-associated protein 1	Mus musculus	178-183
23718696-1	2013	2-tert-Butyl-1,4-benzoquinone (TBQ), an electrophilic metabolite of butylated hydroxyanisole (BHA), causes activation of Nrf2 together with S-arylation of its negative regulator Keap1 in RAW264.7 cells.	Butylated Hydroxyanisole	94-97	kelch-like ECH-associated protein 1	Mus musculus	178-183
23176571-0	2013	Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2.	Hydrogen Sulfide	0-16	kelch-like ECH-associated protein 1	Mus musculus	77-82
23176571-9	2013	NaHS S-sulfhydrated Keap1 at cysteine-151, induced Nrf2 dissociation from Keap1, enhanced Nrf2 nuclear translocation, and stimulated mRNA expression of Nrf2-targeted downstream genes, such as glutamate-cysteine ligase and GSH reductase.	sodium bisulfide	0-4	kelch-like ECH-associated protein 1	Mus musculus	20-25
23176571-9	2013	NaHS S-sulfhydrated Keap1 at cysteine-151, induced Nrf2 dissociation from Keap1, enhanced Nrf2 nuclear translocation, and stimulated mRNA expression of Nrf2-targeted downstream genes, such as glutamate-cysteine ligase and GSH reductase.	sodium bisulfide	0-4	kelch-like ECH-associated protein 1	Mus musculus	74-79
23176571-9	2013	NaHS S-sulfhydrated Keap1 at cysteine-151, induced Nrf2 dissociation from Keap1, enhanced Nrf2 nuclear translocation, and stimulated mRNA expression of Nrf2-targeted downstream genes, such as glutamate-cysteine ligase and GSH reductase.	Cysteine	29-37	kelch-like ECH-associated protein 1	Mus musculus	20-25
23176571-11	2013	CONCLUSION: H2S protects against cellular aging via S-sulfhydration of Keap1 and Nrf2 activation in association with oxidative stress.	Hydrogen Sulfide	12-15	kelch-like ECH-associated protein 1	Mus musculus	71-76
23295186-10	2013	These results suggest that ROS production triggered by R-LA might modify Kelch-like ECH-associated protein (Keap1), which in turn induces HO-1 expression through the PI3K signaling pathway.	Reactive Oxygen Species	27-30	kelch-like ECH-associated protein 1	Mus musculus	108-113
23250896-6	2013	Keap1-knockdown (Keap1-KD) mice were resistant to 4NQO-induced tongue and esophageal carcinogenesis.	4-Nitroquinoline-1-oxide	50-54	kelch-like ECH-associated protein 1	Mus musculus	0-5
23250896-6	2013	Keap1-knockdown (Keap1-KD) mice were resistant to 4NQO-induced tongue and esophageal carcinogenesis.	4-Nitroquinoline-1-oxide	50-54	kelch-like ECH-associated protein 1	Mus musculus	17-22
22762311-5	2012	Administration of diquat resulted in lipid peroxidation and lethality in wild-type mice, which were more in Nrf2-null mice and less in Keap1-KD mice.	Diquat	18-24	kelch-like ECH-associated protein 1	Mus musculus	135-140
23294286-5	2013	The induction of HO-1 by 7-O-galloyltaxifolin was primarily associated with the production of reactive oxygen species and phosphorylation of mitogen-activated protein kinases (MAPKs), including p38 MAPKs and ERKs, followed by nuclear accumulation of Nrf2 and downregulation of Keap1, a negative regulator of Nrf2.	7-O-galloyltaxifolin	25-45	kelch-like ECH-associated protein 1	Mus musculus	277-282
22995787-0	2012	Protective action of nipradilol mediated through S-nitrosylation of Keap1 and HO-1 induction in retinal ganglion cells.	nipradilol	21-31	kelch-like ECH-associated protein 1	Mus musculus	68-73
22762311-11	2012	After diquat treatment, the mRNA of the GSH synthesis enzyme Gclc was increased in Keap1-KD, but not in Nrf2-null mice.	Diquat	6-12	kelch-like ECH-associated protein 1	Mus musculus	83-88
22762311-11	2012	After diquat treatment, the mRNA of the GSH synthesis enzyme Gclc was increased in Keap1-KD, but not in Nrf2-null mice.	Glutathione	40-43	kelch-like ECH-associated protein 1	Mus musculus	83-88
22872865-10	2012	We also found that treatment of cells with tert-butylhydroquinone accelerated the Keap1 degradation.	2-tert-butylhydroquinone	43-65	kelch-like ECH-associated protein 1	Mus musculus	82-87
22966037-5	2012	Electrophiles and oxidants modify critical cysteine thiols of Keap1 and Nrf2 to inhibit Nrf2 ubiquitination, leading to Nrf2 activation and induction.	Cysteine	43-51	kelch-like ECH-associated protein 1	Mus musculus	62-67
22966037-5	2012	Electrophiles and oxidants modify critical cysteine thiols of Keap1 and Nrf2 to inhibit Nrf2 ubiquitination, leading to Nrf2 activation and induction.	Sulfhydryl Compounds	52-58	kelch-like ECH-associated protein 1	Mus musculus	62-67
22367278-6	2012	Oxidative stress was significantly increased in the livers of the Nrf2-null and suppressed in the livers of the Keap1-kd compared to that of WT, based on the levels of 4-hydroxy-2-nonenal and malondialdehyde.	Malondialdehyde	192-207	kelch-like ECH-associated protein 1	Mus musculus	112-117
22732183-1	2012	The Keap1-Nrf2 system plays a critical role in cellular defense against electrophiles and reactive oxygen species.	Reactive Oxygen Species	90-113	kelch-like ECH-associated protein 1	Mus musculus	4-9
22732183-2	2012	Keap1 possesses a number of cysteine residues, some of which are highly reactive and serves as sensors for these insults.	Cysteine	28-36	kelch-like ECH-associated protein 1	Mus musculus	0-5
22732183-4	2012	However, this mutation does not affect the other set of electrophiles, suggesting that multiple sensor systems reside within the cysteine residues of Keap1.	Cysteine	129-137	kelch-like ECH-associated protein 1	Mus musculus	150-155
22732183-5	2012	The precise contribution of each reactive cysteine to the sensor function of Keap1 remains to be clarified.	Cysteine	42-50	kelch-like ECH-associated protein 1	Mus musculus	77-82
22732183-12	2012	Experiments testing protective effects against the cytotoxicity of 1-chloro-2,4-dinitrobenzene of sulforaphane and 15d-PG-J(2) in Keap1-C151S-expressing macrophages revealed that the former inducer was effective, while the latter was not.	Dinitrochlorobenzene	67-94	kelch-like ECH-associated protein 1	Mus musculus	130-135
22732183-13	2012	These results thus indicate that there exists distinct utilization of Keap1 cysteine residues by different chemicals that trigger the response of the Keap1-Nrf2 system, and further substantiate the notion that there are multiple sensing mechanisms within Keap1 cysteine residues.	Cysteine	76-84	kelch-like ECH-associated protein 1	Mus musculus	70-75
22732183-13	2012	These results thus indicate that there exists distinct utilization of Keap1 cysteine residues by different chemicals that trigger the response of the Keap1-Nrf2 system, and further substantiate the notion that there are multiple sensing mechanisms within Keap1 cysteine residues.	Cysteine	76-84	kelch-like ECH-associated protein 1	Mus musculus	150-155
22732183-13	2012	These results thus indicate that there exists distinct utilization of Keap1 cysteine residues by different chemicals that trigger the response of the Keap1-Nrf2 system, and further substantiate the notion that there are multiple sensing mechanisms within Keap1 cysteine residues.	Cysteine	76-84	kelch-like ECH-associated protein 1	Mus musculus	150-155
22732183-13	2012	These results thus indicate that there exists distinct utilization of Keap1 cysteine residues by different chemicals that trigger the response of the Keap1-Nrf2 system, and further substantiate the notion that there are multiple sensing mechanisms within Keap1 cysteine residues.	Cysteine	261-269	kelch-like ECH-associated protein 1	Mus musculus	70-75
22732183-13	2012	These results thus indicate that there exists distinct utilization of Keap1 cysteine residues by different chemicals that trigger the response of the Keap1-Nrf2 system, and further substantiate the notion that there are multiple sensing mechanisms within Keap1 cysteine residues.	Cysteine	261-269	kelch-like ECH-associated protein 1	Mus musculus	150-155
22732183-13	2012	These results thus indicate that there exists distinct utilization of Keap1 cysteine residues by different chemicals that trigger the response of the Keap1-Nrf2 system, and further substantiate the notion that there are multiple sensing mechanisms within Keap1 cysteine residues.	Cysteine	261-269	kelch-like ECH-associated protein 1	Mus musculus	150-155
22609006-3	2012	Selective knockdown of Keap1 with siRNA promoted Nrf2-dependent expression of phase II genes in endothelial cells, such as heme oxygenase-1 (HO-1), glutamate-cysteine ligase (GCL), and peroxiredoxin-1 (Prx1), resulting in the elevation of cellular glutathione levels and suppression of tumor necrosis factor (TNF)-alpha-induced intracellular H(2)O(2) accumulation.	Glutathione	248-259	kelch-like ECH-associated protein 1	Mus musculus	23-28
22659146-3	2012	The acetylenic tricyclic bis(cyano enone) TBE-31 is a strong inhibitor of inflammation and a potent inducer of the Keap1/Nrf2/ARE pathway, which orchestrates the expression of a large network of cytoprotective genes.	acetylenic tricyclic bis(cyano enone) tbe	4-45	kelch-like ECH-associated protein 1	Mus musculus	115-120
22659146-4	2012	We now report that long-term (five days per week for four weeks) topical daily applications of small (200 nmol) quantities of TBE-31 cause a robust systemic induction of the Keap1/Nrf2/ARE pathway and decreases the 6-TG incorporation in DNA of skin, blood, and liver of azathioprine-treated mice, indicating extraordinary bioavailability and efficacy.	tbe	126-129	kelch-like ECH-associated protein 1	Mus musculus	174-179
22659146-5	2012	In addition, TBE-31, at nanomolar concentrations, protects cells with 6-TG in their genomic DNA against oxidative stress caused by UVA radiation through induction of the Keap1/Nrf2/ARE pathway.	tbe	13-16	kelch-like ECH-associated protein 1	Mus musculus	170-175
22180572-4	2012	Since GPx2 is induced by the chemopreventive sulforaphane (SFN) via the nuclear factor E2-related factor 2 (Nrf2)/Keap1 system, the susceptibility of GPx2-KO and wild-type (WT) mice to azoxymethane and dextran sulfate sodium (AOM/DSS)-induced colon carcinogenesis was tested under different selenium states and SFN applications.	sulforaphane	59-62	kelch-like ECH-associated protein 1	Mus musculus	114-119
22578244-6	2012	In conclusion, the present results demonstrate for the first time that DGC protects neuronal cells against glutamate-induced oxidative injury through the induction of HO-1 expression, which is, in turn, activated maybe through Nrf2-Keap1 and PI3K/AKT signaling pathways.	Glutamic Acid	107-116	kelch-like ECH-associated protein 1	Mus musculus	232-237
22390900-3	2012	The organosulfur compounds, allicin can activate Nrf2, because it has an electrophilic center, which can serve as an attack site for nucleophiles, such as specific protein sulfhydryl groups present on Keap1.	organosulfur	4-16	kelch-like ECH-associated protein 1	Mus musculus	201-206
22390900-3	2012	The organosulfur compounds, allicin can activate Nrf2, because it has an electrophilic center, which can serve as an attack site for nucleophiles, such as specific protein sulfhydryl groups present on Keap1.	allicin	28-35	kelch-like ECH-associated protein 1	Mus musculus	201-206
21775727-8	2011	High performance liquid chromatography-ultraviolet absorbance analysis confirmed that hepatic NADPH concentration was lowest in Nrf2-null mice and highest in Keap1-HKO mice.	NADP	94-99	kelch-like ECH-associated protein 1	Mus musculus	158-163
22214931-1	2012	In the previous studies, we reported that carnosic acid (CA) protects cortical neurons by activating the Keap1/Nrf2 pathway, which activation is initiated by S-alkylation of the critical cysteine thiol of the Keap1 protein by the "electrophilic"quinone-type CA.	salvin	42-55	kelch-like ECH-associated protein 1	Mus musculus	105-110
22214931-1	2012	In the previous studies, we reported that carnosic acid (CA) protects cortical neurons by activating the Keap1/Nrf2 pathway, which activation is initiated by S-alkylation of the critical cysteine thiol of the Keap1 protein by the "electrophilic"quinone-type CA.	salvin	42-55	kelch-like ECH-associated protein 1	Mus musculus	209-214
22214931-1	2012	In the previous studies, we reported that carnosic acid (CA) protects cortical neurons by activating the Keap1/Nrf2 pathway, which activation is initiated by S-alkylation of the critical cysteine thiol of the Keap1 protein by the "electrophilic"quinone-type CA.	cysteine thiol	187-201	kelch-like ECH-associated protein 1	Mus musculus	105-110
22214931-1	2012	In the previous studies, we reported that carnosic acid (CA) protects cortical neurons by activating the Keap1/Nrf2 pathway, which activation is initiated by S-alkylation of the critical cysteine thiol of the Keap1 protein by the "electrophilic"quinone-type CA.	cysteine thiol	187-201	kelch-like ECH-associated protein 1	Mus musculus	209-214
22214931-1	2012	In the previous studies, we reported that carnosic acid (CA) protects cortical neurons by activating the Keap1/Nrf2 pathway, which activation is initiated by S-alkylation of the critical cysteine thiol of the Keap1 protein by the "electrophilic"quinone-type CA.	quinone	245-252	kelch-like ECH-associated protein 1	Mus musculus	105-110
22214931-1	2012	In the previous studies, we reported that carnosic acid (CA) protects cortical neurons by activating the Keap1/Nrf2 pathway, which activation is initiated by S-alkylation of the critical cysteine thiol of the Keap1 protein by the "electrophilic"quinone-type CA.	quinone	245-252	kelch-like ECH-associated protein 1	Mus musculus	209-214
22014577-4	2011	Mechanistic analysis revealed that fumarate modifies cysteine residues within the Kelch-like ECH-associated protein 1 (KEAP1), abrogating its ability to repress the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-mediated antioxidant response pathway, suggesting a role for Nrf2 dysregulation in FH-associated cysts and tumors.	Fumarates	35-43	kelch-like ECH-associated protein 1	Mus musculus	82-117
22014577-4	2011	Mechanistic analysis revealed that fumarate modifies cysteine residues within the Kelch-like ECH-associated protein 1 (KEAP1), abrogating its ability to repress the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-mediated antioxidant response pathway, suggesting a role for Nrf2 dysregulation in FH-associated cysts and tumors.	Fumarates	35-43	kelch-like ECH-associated protein 1	Mus musculus	119-124
22014577-4	2011	Mechanistic analysis revealed that fumarate modifies cysteine residues within the Kelch-like ECH-associated protein 1 (KEAP1), abrogating its ability to repress the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-mediated antioxidant response pathway, suggesting a role for Nrf2 dysregulation in FH-associated cysts and tumors.	Cysteine	53-61	kelch-like ECH-associated protein 1	Mus musculus	82-117
22014577-4	2011	Mechanistic analysis revealed that fumarate modifies cysteine residues within the Kelch-like ECH-associated protein 1 (KEAP1), abrogating its ability to repress the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-mediated antioxidant response pathway, suggesting a role for Nrf2 dysregulation in FH-associated cysts and tumors.	Cysteine	53-61	kelch-like ECH-associated protein 1	Mus musculus	119-124
21651925-0	2011	Participation of covalent modification of Keap1 in the activation of Nrf2 by tert-butylbenzoquinone, an electrophilic metabolite of butylated hydroxyanisole.	Butylated Hydroxyanisole	132-156	kelch-like ECH-associated protein 1	Mus musculus	42-47
21385624-3	2011	Upon the exposure to electrophilic and oxidative stress, reactive cysteine residues in Keap1 are covalently modified, which abrogates the E3 ligase activity of the Cul3-Keap1 complex.	Cysteine	66-74	kelch-like ECH-associated protein 1	Mus musculus	87-92
21651925-3	2011	BHA and TBHQ activate Nrf2, a transcription factor that is negatively regulated by Keap1 and plays a role in the initial response to chemicals causing oxidative or electrophilic stress, although, the exact mechanism of Nrf2 activation remains unclear.	Butylated Hydroxyanisole	0-3	kelch-like ECH-associated protein 1	Mus musculus	83-88
21651925-3	2011	BHA and TBHQ activate Nrf2, a transcription factor that is negatively regulated by Keap1 and plays a role in the initial response to chemicals causing oxidative or electrophilic stress, although, the exact mechanism of Nrf2 activation remains unclear.	2-tert-butylhydroquinone	8-12	kelch-like ECH-associated protein 1	Mus musculus	83-88
21651925-7	2011	A click chemistry technique indicated that TBQ chemically modifies Keap1.	tert-butyl benzoquinone	43-46	kelch-like ECH-associated protein 1	Mus musculus	67-72
21651925-8	2011	Furthermore, ultrahigh performance liquid chromatography-tandem mass spectrometry analysis with purified Keap1 revealed that TBQ covalently binds to Keap1 through Cys23, Cys151, Cys226, and Cys368.	tert-butyl benzoquinone	125-128	kelch-like ECH-associated protein 1	Mus musculus	105-110
21651925-8	2011	Furthermore, ultrahigh performance liquid chromatography-tandem mass spectrometry analysis with purified Keap1 revealed that TBQ covalently binds to Keap1 through Cys23, Cys151, Cys226, and Cys368.	tert-butyl benzoquinone	125-128	kelch-like ECH-associated protein 1	Mus musculus	149-154
21651925-9	2011	These results suggest that TBQ derived from BHA activates Nrf2 through electrophilic modification of Keap1 rather than ROS formation.	tert-butyl benzoquinone	27-30	kelch-like ECH-associated protein 1	Mus musculus	101-106
21651925-9	2011	These results suggest that TBQ derived from BHA activates Nrf2 through electrophilic modification of Keap1 rather than ROS formation.	Butylated Hydroxyanisole	44-47	kelch-like ECH-associated protein 1	Mus musculus	101-106
21799073-9	2011	LPS stimulation resulted in greater reactive oxygen species-induced cell surface transport of TLR4 from trans-Golgi network and subsequent TLR4 downstream signaling (recruitment of MYD88 and TRIF, phosphorylation of IkB and IRF3, and cytokine expression) in macrophages of LysM-Nrf2(-/-) compared with LysM-Keap1(-/-) mice and floxed controls.	Reactive Oxygen Species	36-59	kelch-like ECH-associated protein 1	Mus musculus	307-312
21039417-9	2011	Consistently, treatment of sauchinone enhanced Nrf2 phosphorylation with a reciprocal decrease in its interaction with Kelch-like ECH-associated protein-1.	sauchinone	27-37	kelch-like ECH-associated protein 1	Mus musculus	119-154
21385624-3	2011	Upon the exposure to electrophilic and oxidative stress, reactive cysteine residues in Keap1 are covalently modified, which abrogates the E3 ligase activity of the Cul3-Keap1 complex.	Cysteine	66-74	kelch-like ECH-associated protein 1	Mus musculus	169-174
21384861-3	2011	In studies using 1,2-naphthoquinone (1,2-NQ) as a model quinone, we found that Keap1, the negative regulator of Nrf2, was readily arylated at its reactive thiols by 1,2-NQ.	Sulfhydryl Compounds	155-161	kelch-like ECH-associated protein 1	Mus musculus	79-84
21217061-5	2011	These effects of high glucose were significantly attenuated by small interfering RNA (siRNA) downregulation of Nrf2 or overexpression of Keap-1, which inactivates Nrf2.	Glucose	22-29	kelch-like ECH-associated protein 1	Mus musculus	137-143
21177379-8	2011	Similar to the transgenic mouse Keap1(G430C) mutant, Keap1(C273&amp;288A) substitutions also diminished Keap1(WT) activity in vivo.	Adenosine Monophosphate	64-67	kelch-like ECH-associated protein 1	Mus musculus	53-58
21177379-8	2011	Similar to the transgenic mouse Keap1(G430C) mutant, Keap1(C273&amp;288A) substitutions also diminished Keap1(WT) activity in vivo.	Adenosine Monophosphate	64-67	kelch-like ECH-associated protein 1	Mus musculus	53-58
21177379-8	2011	Similar to the transgenic mouse Keap1(G430C) mutant, Keap1(C273&amp;288A) substitutions also diminished Keap1(WT) activity in vivo.	Adenosine Monophosphate	64-67	kelch-like ECH-associated protein 1	Mus musculus	110-112
21734707-2	2011	Normally, ROS levels are tightly controlled by an inducible antioxidant program that responds to cellular stressors and is predominantly regulated by the transcription factor Nrf2 (also known as Nfe2l2) and its repressor protein Keap1 (refs 2-5).	Reactive Oxygen Species	10-13	kelch-like ECH-associated protein 1	Mus musculus	229-234
21734707-4	2011	Indeed, somatic mutations that disrupt the Nrf2-Keap1 interaction to stabilize Nrf2 and increase the constitutive transcription of Nrf2 target genes were recently identified, indicating that enhanced ROS detoxification and additional Nrf2 functions may in fact be pro-tumorigenic.	Reactive Oxygen Species	200-203	kelch-like ECH-associated protein 1	Mus musculus	48-53
21538894-6	2011	This suggests that glyceollins may cause Nrf2-mediated phase 2 enzyme induction through activation of the PI3K signaling pathway as well as interaction with Keap1.	glyceollin	19-30	kelch-like ECH-associated protein 1	Mus musculus	157-162
21538894-7	2011	Our molecular docking simulations also suggest that the glyceollin isomers tightly bind into the binding pocket around Cys151, preventing Nrf2 from docking to Keap1.	glyceollin	56-66	kelch-like ECH-associated protein 1	Mus musculus	159-164
21538894-8	2011	In conclusion, the current data suggest that glyceollins induced phase 2 detoxifying enzymes likely through promoting nuclear translocation of Nrf2, which is known to be regulated by phosphorylation of Nrf2 and/or disrupting Keap1-Nrf2 complex formation.	glyceollin	45-56	kelch-like ECH-associated protein 1	Mus musculus	225-230
21384861-0	2011	Initial response and cellular protection through the Keap1/Nrf2 system during the exposure of primary mouse hepatocytes to 1,2-naphthoquinone.	1,2-naphthoquinone	123-141	kelch-like ECH-associated protein 1	Mus musculus	53-58
21384861-3	2011	In studies using 1,2-naphthoquinone (1,2-NQ) as a model quinone, we found that Keap1, the negative regulator of Nrf2, was readily arylated at its reactive thiols by 1,2-NQ.	1,2-naphthoquinone	17-35	kelch-like ECH-associated protein 1	Mus musculus	79-84
21384861-3	2011	In studies using 1,2-naphthoquinone (1,2-NQ) as a model quinone, we found that Keap1, the negative regulator of Nrf2, was readily arylated at its reactive thiols by 1,2-NQ.	1,2-naphthoquinone	37-43	kelch-like ECH-associated protein 1	Mus musculus	79-84
21384861-3	2011	In studies using 1,2-naphthoquinone (1,2-NQ) as a model quinone, we found that Keap1, the negative regulator of Nrf2, was readily arylated at its reactive thiols by 1,2-NQ.	quinone	28-35	kelch-like ECH-associated protein 1	Mus musculus	79-84
21414291-4	2011	The amino acid sequence DEETGE, located at amino acid 77-82 of Nrf2, is critical for Nrf2-Keap1 interaction, and synthetic peptides containing this sequence can be used to disrupt the complex in vitro.	Peptides	123-131	kelch-like ECH-associated protein 1	Mus musculus	90-95
21354971-9	2011	Furthermore, the immediate metabolite of dimethylfumarate, monomethylfumarate, leads to direct modification of the inhibitor of nuclear factor (erythroid-derived 2)-related factor 2, Kelch-like ECH-associated protein 1, at cysteine residue 151.	Dimethyl Fumarate	41-57	kelch-like ECH-associated protein 1	Mus musculus	144-218
21354971-9	2011	Furthermore, the immediate metabolite of dimethylfumarate, monomethylfumarate, leads to direct modification of the inhibitor of nuclear factor (erythroid-derived 2)-related factor 2, Kelch-like ECH-associated protein 1, at cysteine residue 151.	citraconic acid	59-77	kelch-like ECH-associated protein 1	Mus musculus	144-218
21354971-9	2011	Furthermore, the immediate metabolite of dimethylfumarate, monomethylfumarate, leads to direct modification of the inhibitor of nuclear factor (erythroid-derived 2)-related factor 2, Kelch-like ECH-associated protein 1, at cysteine residue 151.	Cysteine	223-231	kelch-like ECH-associated protein 1	Mus musculus	144-218
21245377-3	2011	We now show that glycogen synthase kinase 3 (GSK-3) phosphorylates a group of Ser residues in the Neh6 domain of mouse Nrf2 that overlap with an SCF/beta-TrCP destruction motif (DSGIS, residues 334 to 338) and promotes its degradation in a Keap1-independent manner.	Serine	78-81	kelch-like ECH-associated protein 1	Mus musculus	240-245
21075092-4	2011	In the peri-infarct regions, a steady level of Keap1 showed a decremental expression started at 2h of reperfusion after 60 min of transient middle cerebral artery occlusion (tMCAO).	Deuterium	96-98	kelch-like ECH-associated protein 1	Mus musculus	47-52
21075092-4	2011	In the peri-infarct regions, a steady level of Keap1 showed a decremental expression started at 2h of reperfusion after 60 min of transient middle cerebral artery occlusion (tMCAO).	tmcao	174-179	kelch-like ECH-associated protein 1	Mus musculus	47-52
21384861-3	2011	In studies using 1,2-naphthoquinone (1,2-NQ) as a model quinone, we found that Keap1, the negative regulator of Nrf2, was readily arylated at its reactive thiols by 1,2-NQ.	1,2-naphthoquinone	165-171	kelch-like ECH-associated protein 1	Mus musculus	79-84
21384861-7	2011	However, deletion of the negative regulatory protein, Keap1, drastically reduced the covalent binding by 1,2-NQ and its cellular toxicity.	1,2-naphthoquinone	105-111	kelch-like ECH-associated protein 1	Mus musculus	54-59
21384861-9	2011	These findings suggest that the Keap1/Nrf2 system is essential for the prevention of cell damage resulting from exposure to 1,2-NQ.	1,2-naphthoquinone	124-130	kelch-like ECH-associated protein 1	Mus musculus	32-37
20513672-11	2010	In contrast, Keap1-knockdown mutant mice harboring high-level Nrf2 expression displayed increased resistance against the cancer cell metastasis to the lung, accompanied by a decrease in ROS in the MDSCs fraction.	Reactive Oxygen Species	186-189	kelch-like ECH-associated protein 1	Mus musculus	13-18
20122947-4	2010	In higher organisms, a more sophisticated means of tightly regulating Nrf2 activity was introduced via the cysteine-rich kelch-like ECH-associated protein 1 (Keap1), thus suggesting a need to modulate Nrf2 activity.	Cysteine	107-115	kelch-like ECH-associated protein 1	Mus musculus	158-163
20716282-3	2010	These electrophilic fatty acids activate cytosolic and nuclear stress-response pathways (through Nrf2/Keap1 and PPARgamma, for example).	Fatty Acids	20-31	kelch-like ECH-associated protein 1	Mus musculus	102-107
20498004-5	2010	The same BaP treatment to Hepa1c1c7 cells also downregulates the Keap1 message and protein levels to a similar extent.	Benzo(a)pyrene	9-12	kelch-like ECH-associated protein 1	Mus musculus	65-70
20714298-3	2010	Further investigations indicated that the activation of Keap1-Nrf2 pathway by PDDYT might be attributed to the activation of Akt and depleting the cellular glutathione (GSH).	Glutathione	156-167	kelch-like ECH-associated protein 1	Mus musculus	56-61
20714298-3	2010	Further investigations indicated that the activation of Keap1-Nrf2 pathway by PDDYT might be attributed to the activation of Akt and depleting the cellular glutathione (GSH).	Glutathione	169-172	kelch-like ECH-associated protein 1	Mus musculus	56-61
20416283-10	2010	While RNAi depletion of Keap1 led to reduced toxicity following exposure to DNCB, depletion of Nrf2 and NF-kappaB augmented toxicity.	Dinitrochlorobenzene	76-80	kelch-like ECH-associated protein 1	Mus musculus	24-29
20416283-12	2010	We demonstrate that Keap1/Nrf2 and NF-kappaB respond differently to electrophiles that bind proteins covalently and the redox perturbation associated with glutathione depletion, and that crosstalk may enable NF-kappaB to partly influence Nrf2 expression during cellular stress.	Glutathione	155-166	kelch-like ECH-associated protein 1	Mus musculus	20-25
20404090-5	2010	We previously reported that hepatocyte-specific Keap1 knockout (Keap1(flox/-)::Albumin-Cre) mice are viable and more resistant to acute toxicity of acetaminophen (APAP).	Acetaminophen	148-161	kelch-like ECH-associated protein 1	Mus musculus	48-53
20404090-5	2010	We previously reported that hepatocyte-specific Keap1 knockout (Keap1(flox/-)::Albumin-Cre) mice are viable and more resistant to acute toxicity of acetaminophen (APAP).	Acetaminophen	148-161	kelch-like ECH-associated protein 1	Mus musculus	64-69
20404090-5	2010	We previously reported that hepatocyte-specific Keap1 knockout (Keap1(flox/-)::Albumin-Cre) mice are viable and more resistant to acute toxicity of acetaminophen (APAP).	Acetaminophen	163-167	kelch-like ECH-associated protein 1	Mus musculus	48-53
20404090-5	2010	We previously reported that hepatocyte-specific Keap1 knockout (Keap1(flox/-)::Albumin-Cre) mice are viable and more resistant to acute toxicity of acetaminophen (APAP).	Acetaminophen	163-167	kelch-like ECH-associated protein 1	Mus musculus	64-69
20439747-2	2010	The mechanism of action of sulforaphane is believed to involve modifications of critical cysteine residues of Keap1, which lead to stabilization of Nrf2 to activate the antioxidant response element of phase 2 enzymes.	sulforaphane	27-39	kelch-like ECH-associated protein 1	Mus musculus	110-115
20439747-2	2010	The mechanism of action of sulforaphane is believed to involve modifications of critical cysteine residues of Keap1, which lead to stabilization of Nrf2 to activate the antioxidant response element of phase 2 enzymes.	Cysteine	89-97	kelch-like ECH-associated protein 1	Mus musculus	110-115
20439747-3	2010	However, the dithiocarbamate functional group formed by a reversible reaction between isothiocyanate of sulforaphane and sulfhydryl nucleophiles of Keap1 is kinetically labile, and such modification in intact cells has not yet been demonstrated.	Dithiocarbamate	13-28	kelch-like ECH-associated protein 1	Mus musculus	148-153
20439747-3	2010	However, the dithiocarbamate functional group formed by a reversible reaction between isothiocyanate of sulforaphane and sulfhydryl nucleophiles of Keap1 is kinetically labile, and such modification in intact cells has not yet been demonstrated.	isothiocyanic acid	86-100	kelch-like ECH-associated protein 1	Mus musculus	148-153
20439747-3	2010	However, the dithiocarbamate functional group formed by a reversible reaction between isothiocyanate of sulforaphane and sulfhydryl nucleophiles of Keap1 is kinetically labile, and such modification in intact cells has not yet been demonstrated.	sulforaphane	104-116	kelch-like ECH-associated protein 1	Mus musculus	148-153
20439747-3	2010	However, the dithiocarbamate functional group formed by a reversible reaction between isothiocyanate of sulforaphane and sulfhydryl nucleophiles of Keap1 is kinetically labile, and such modification in intact cells has not yet been demonstrated.	sulfhydryl nucleophiles	121-144	kelch-like ECH-associated protein 1	Mus musculus	148-153
20439747-7	2010	We further show in living cells that a sulfoxythiocarbamate analog can label Keap1 on several key cysteine residues as well as other cellular proteins offering new insights into the mechanism of chemoprotection.	sulfoxythiocarbamate	39-59	kelch-like ECH-associated protein 1	Mus musculus	77-82
20439747-7	2010	We further show in living cells that a sulfoxythiocarbamate analog can label Keap1 on several key cysteine residues as well as other cellular proteins offering new insights into the mechanism of chemoprotection.	Cysteine	98-106	kelch-like ECH-associated protein 1	Mus musculus	77-82
19520915-7	2010	Deletion of Keap1 in airway epithelium decreased Keap1 protein levels and significantly increased the total level of glutathione in the lungs.	Glutathione	117-128	kelch-like ECH-associated protein 1	Mus musculus	12-17
19941258-1	2010	In our previous studies, we have reported that carnosic acid (CA) and carnosol (CS) originating from rosemary protects cortical neurons by inducing phase 2 enzymes, the induction of which was initiated by activation of the Keap1/Nrf2 pathway , , .	salvin	47-60	kelch-like ECH-associated protein 1	Mus musculus	223-228
19941258-1	2010	In our previous studies, we have reported that carnosic acid (CA) and carnosol (CS) originating from rosemary protects cortical neurons by inducing phase 2 enzymes, the induction of which was initiated by activation of the Keap1/Nrf2 pathway , , .	carnosol	70-78	kelch-like ECH-associated protein 1	Mus musculus	223-228
19941258-1	2010	In our previous studies, we have reported that carnosic acid (CA) and carnosol (CS) originating from rosemary protects cortical neurons by inducing phase 2 enzymes, the induction of which was initiated by activation of the Keap1/Nrf2 pathway , , .	carnosol	80-82	kelch-like ECH-associated protein 1	Mus musculus	223-228
19941258-9	2010	These results suggest that pro-electrophilic compounds such as CA and CS may protect cortical neurons by causing the following sequential events: S-alkylation --&gt; activation of the Keap1/Nrf2 pathway --&gt; transcriptional activation --&gt; induction of phase 2 enzymes --&gt; activation of GSH metabolism --&gt; neuroprotection.	carnosol	70-72	kelch-like ECH-associated protein 1	Mus musculus	184-189
19941258-9	2010	These results suggest that pro-electrophilic compounds such as CA and CS may protect cortical neurons by causing the following sequential events: S-alkylation --&gt; activation of the Keap1/Nrf2 pathway --&gt; transcriptional activation --&gt; induction of phase 2 enzymes --&gt; activation of GSH metabolism --&gt; neuroprotection.	Glutathione	294-297	kelch-like ECH-associated protein 1	Mus musculus	184-189
20133743-0	2010	Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains.	Glycine	96-103	kelch-like ECH-associated protein 1	Mus musculus	0-5
20133743-4	2010	In contrast, upon exposure to oxidative and electrophilic stress, reactive cysteine residues in intervening region (IVR) and Broad complex, Tramtrack, and Bric-a-Brac domains of Keap1 are modified by electrophiles.	Cysteine	75-83	kelch-like ECH-associated protein 1	Mus musculus	178-183
19808700-0	2010	Critical cysteine residues of Kelch-like ECH-associated protein 1 in arsenic sensing and suppression of nuclear factor erythroid 2-related factor 2.	Cysteine	9-17	kelch-like ECH-associated protein 1	Mus musculus	30-65
19808700-0	2010	Critical cysteine residues of Kelch-like ECH-associated protein 1 in arsenic sensing and suppression of nuclear factor erythroid 2-related factor 2.	Arsenic	69-76	kelch-like ECH-associated protein 1	Mus musculus	30-65
19808700-2	2010	Here we analyzed arsenic-Kelch-like ECH-associated protein 1 (Keap1) cysteine thiol interaction in Nrf2 activation.	cysteine thiol	69-83	kelch-like ECH-associated protein 1	Mus musculus	17-60
19808700-2	2010	Here we analyzed arsenic-Kelch-like ECH-associated protein 1 (Keap1) cysteine thiol interaction in Nrf2 activation.	cysteine thiol	69-83	kelch-like ECH-associated protein 1	Mus musculus	62-67
19808700-3	2010	Arsenic-based Nrf2 activators, fluorescent biarsenical labeling reagent (FlAsH) and phenylarsine oxide (PAO), were used to probe binding of arsenic to Keap1.	Arsenic	0-7	kelch-like ECH-associated protein 1	Mus musculus	151-156
19808700-6	2010	PAO affinity beads effectively pulled down Keap1 in vitro and from hepa1c1c7 cells.	oxophenylarsine	0-3	kelch-like ECH-associated protein 1	Mus musculus	43-48
19808700-7	2010	Arsenic, tBHQ, free PAO, or cadmium blocked Keap1 pulldown.	Arsenic	0-7	kelch-like ECH-associated protein 1	Mus musculus	44-49
19808700-7	2010	Arsenic, tBHQ, free PAO, or cadmium blocked Keap1 pulldown.	2-tert-butylhydroquinone	9-13	kelch-like ECH-associated protein 1	Mus musculus	44-49
19808700-7	2010	Arsenic, tBHQ, free PAO, or cadmium blocked Keap1 pulldown.	oxophenylarsine	20-23	kelch-like ECH-associated protein 1	Mus musculus	44-49
19808700-7	2010	Arsenic, tBHQ, free PAO, or cadmium blocked Keap1 pulldown.	Cadmium	28-35	kelch-like ECH-associated protein 1	Mus musculus	44-49
19808700-8	2010	Furthermore, arsenic and free PAO significantly reduced the free thiol contents of purified or endogenous Keap1.	Arsenic	13-20	kelch-like ECH-associated protein 1	Mus musculus	106-111
19808700-8	2010	Furthermore, arsenic and free PAO significantly reduced the free thiol contents of purified or endogenous Keap1.	oxophenylarsine	30-33	kelch-like ECH-associated protein 1	Mus musculus	106-111
19808700-8	2010	Furthermore, arsenic and free PAO significantly reduced the free thiol contents of purified or endogenous Keap1.	Sulfhydryl Compounds	65-70	kelch-like ECH-associated protein 1	Mus musculus	106-111
19808700-9	2010	Thus, arsenic, FlAsH, and PAO, as well as tBHQ and cadmium, bind to Keap1 cysteine thiols in a similar fashion.	Arsenic	6-13	kelch-like ECH-associated protein 1	Mus musculus	68-73
19808700-9	2010	Thus, arsenic, FlAsH, and PAO, as well as tBHQ and cadmium, bind to Keap1 cysteine thiols in a similar fashion.	oxophenylarsine	26-29	kelch-like ECH-associated protein 1	Mus musculus	68-73
19808700-9	2010	Thus, arsenic, FlAsH, and PAO, as well as tBHQ and cadmium, bind to Keap1 cysteine thiols in a similar fashion.	2-tert-butylhydroquinone	42-46	kelch-like ECH-associated protein 1	Mus musculus	68-73
19808700-9	2010	Thus, arsenic, FlAsH, and PAO, as well as tBHQ and cadmium, bind to Keap1 cysteine thiols in a similar fashion.	Cadmium	51-58	kelch-like ECH-associated protein 1	Mus musculus	68-73
19808700-9	2010	Thus, arsenic, FlAsH, and PAO, as well as tBHQ and cadmium, bind to Keap1 cysteine thiols in a similar fashion.	cysteine thiols	74-89	kelch-like ECH-associated protein 1	Mus musculus	68-73
19808700-16	2010	Our findings support a model in which arsenic binds to different sets of Keap1 cysteine residues to regulate divergent functions in Nrf2 signal transduction.	Arsenic	38-45	kelch-like ECH-associated protein 1	Mus musculus	73-78
19808700-16	2010	Our findings support a model in which arsenic binds to different sets of Keap1 cysteine residues to regulate divergent functions in Nrf2 signal transduction.	Cysteine	79-87	kelch-like ECH-associated protein 1	Mus musculus	73-78
19560419-2	2009	Nrf2 is constantly ubiquitinated by a Keap1 dimer that interacts with a weak-binding (29)DLG motif and a strong-binding (79)ETGE motif in Nrf2, resulting in degradation of Nrf2.	etge	124-128	kelch-like ECH-associated protein 1	Mus musculus	38-43
19952498-0	2009	Catechol estrogens mediated activation of Nrf2 through covalent modification of its quinone metabolite to Keap1.	catechol	0-8	kelch-like ECH-associated protein 1	Mus musculus	106-111
19952498-0	2009	Catechol estrogens mediated activation of Nrf2 through covalent modification of its quinone metabolite to Keap1.	quinone	84-91	kelch-like ECH-associated protein 1	Mus musculus	106-111
19952498-6	2009	Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) analysis revealed Keap1 undergoes modification by such quinoid species through multiple reactive thiol groups.	quinoid	147-154	kelch-like ECH-associated protein 1	Mus musculus	110-115
19952498-6	2009	Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) analysis revealed Keap1 undergoes modification by such quinoid species through multiple reactive thiol groups.	Sulfhydryl Compounds	189-194	kelch-like ECH-associated protein 1	Mus musculus	110-115
19952498-7	2009	These results suggest that Nrf2 activation during redox cycling of catechol estrogens is dominantly attributable to formation of their ortho-quinones that covalently bind to Keap1.	catechol	67-75	kelch-like ECH-associated protein 1	Mus musculus	174-179
19952498-7	2009	These results suggest that Nrf2 activation during redox cycling of catechol estrogens is dominantly attributable to formation of their ortho-quinones that covalently bind to Keap1.	Quinones	141-149	kelch-like ECH-associated protein 1	Mus musculus	174-179
19732748-5	2009	After BDL, the number of hepatic parenchymal necrosis and the reactive oxygen species content were significantly smaller in the livers of the Keap1-kd mice than in those of the WT mice.	Reactive Oxygen Species	62-85	kelch-like ECH-associated protein 1	Mus musculus	142-147
19732748-6	2009	Moreover, the increase in serum bilirubin levels was attenuated in the Keap1-kd mice.	Bilirubin	32-41	kelch-like ECH-associated protein 1	Mus musculus	71-76
19633057-5	2009	Evidence is presented that CETP affected Nrf2-mediated induction of ARE-driven transcription by inhibiting Kelch-like ECH-associated protein 1 (Keap1), a ubiquitin ligase substrate adaptor that negatively regulates Nrf2.	1-cyano-2,3-epithiopropane	27-31	kelch-like ECH-associated protein 1	Mus musculus	107-142
19633057-5	2009	Evidence is presented that CETP affected Nrf2-mediated induction of ARE-driven transcription by inhibiting Kelch-like ECH-associated protein 1 (Keap1), a ubiquitin ligase substrate adaptor that negatively regulates Nrf2.	1-cyano-2,3-epithiopropane	27-31	kelch-like ECH-associated protein 1	Mus musculus	144-149
19633057-7	2009	However, knock-in of mouse Keap1 or zebrafish Keap1a into Keap1(-/-) MEFs repressed Nqo1-luciferase reporter gene activity, but repression by the murine or zebrafish proteins was antagonized by CETP.	1-cyano-2,3-epithiopropane	194-198	kelch-like ECH-associated protein 1	Mus musculus	27-32
19560419-3	2009	Modification of the redox-sensitive cysteine residues on Keap1 disrupts the Keap1-(29)DLG binding, leading to diminished Nrf2 ubiquitination and activation of the antioxidant response.	Cysteine	36-44	kelch-like ECH-associated protein 1	Mus musculus	57-62
19560419-3	2009	Modification of the redox-sensitive cysteine residues on Keap1 disrupts the Keap1-(29)DLG binding, leading to diminished Nrf2 ubiquitination and activation of the antioxidant response.	Cysteine	36-44	kelch-like ECH-associated protein 1	Mus musculus	76-81
18785192-9	2008	CONCLUSION: Nrf2 can be activated via the direct modification of cysteine residues located within the intervening region of Keap1, but also via the substantial depletion of glutathione without the requirement for direct modification of Keap1.	Cysteine	65-73	kelch-like ECH-associated protein 1	Mus musculus	124-129
19371629-1	2009	CDDO-Im is a synthetic triterpenoid recently shown to induce cytoprotective genes through the Nrf2-Keap1 pathway, an important mechanism for the induction of cytoprotective genes in response to oxidative stress.	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	0-7	kelch-like ECH-associated protein 1	Mus musculus	99-104
19371629-1	2009	CDDO-Im is a synthetic triterpenoid recently shown to induce cytoprotective genes through the Nrf2-Keap1 pathway, an important mechanism for the induction of cytoprotective genes in response to oxidative stress.	triterpenoid TP-222	23-35	kelch-like ECH-associated protein 1	Mus musculus	99-104
19129213-0	2009	Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species.	Reactive Oxygen Species	165-188	kelch-like ECH-associated protein 1	Mus musculus	41-46
19227148-12	2009	More importantly, we found 8-nitro-cGMP-dependent S-guanylation of Keap1, a regulatory protein of transcription factor Nrf2, which regulates the transcription of HO-1.	8-nitro	27-34	kelch-like ECH-associated protein 1	Mus musculus	67-72
19227148-12	2009	More importantly, we found 8-nitro-cGMP-dependent S-guanylation of Keap1, a regulatory protein of transcription factor Nrf2, which regulates the transcription of HO-1.	Cyclic GMP	35-39	kelch-like ECH-associated protein 1	Mus musculus	67-72
19246623-11	2009	Moreover, BSP-GSH conjugation activity in the liver of Nrf2-null and Keap1-kd mice was 42% and 237% of WT mice, respectively.	Glutathione	14-17	kelch-like ECH-associated protein 1	Mus musculus	69-74
19246624-0	2009	Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice.	Acetaminophen	23-36	kelch-like ECH-associated protein 1	Mus musculus	54-59
19246624-9	2009	Furthermore, Nqo1, an enzyme capable of detoxifying the reactive intermediate of AA metabolism, N-acetyl-p-benzoquinone imine (NAPQI), had 85% lower activity in Nrf2-null mice and 415% higher activity in Keap1-kd mice relative to wild-type.	N-acetyl-4-benzoquinoneimine	127-132	kelch-like ECH-associated protein 1	Mus musculus	204-209
19246624-10	2009	In conclusion, lack of Nrf2 results in decreased AA glucuronidation, leading to increased AA available for NAPQI formation and decreased efflux of AA-GLUC via Mrp3; however, activation of Nrf2, as in Keap1-kd mice, results in decreased sulfotransferase activity, decreased AA-SULF formation, and enhanced elimination of AA-GLUC due to increased expression of Mrp3.	N-acetyl-4-benzoquinoneimine	107-112	kelch-like ECH-associated protein 1	Mus musculus	200-205
18838692-2	2008	Many chemical and phytochemical agents, all of which react with thiol groups, induce the phase 2 response through their reactivity with critical cysteine thiols of Keap1.	Sulfhydryl Compounds	64-69	kelch-like ECH-associated protein 1	Mus musculus	164-169
18838692-2	2008	Many chemical and phytochemical agents, all of which react with thiol groups, induce the phase 2 response through their reactivity with critical cysteine thiols of Keap1.	cysteine thiols	145-160	kelch-like ECH-associated protein 1	Mus musculus	164-169
18785192-0	2008	The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system.	Acetaminophen	30-43	kelch-like ECH-associated protein 1	Mus musculus	67-72
18785192-3	2008	Nrf2 activation has been proposed to occur through the modification of cysteine residues within Keap1, the cytosolic repressor of Nrf2.	Cysteine	71-79	kelch-like ECH-associated protein 1	Mus musculus	96-101
18785192-4	2008	We hypothesized that acetaminophen activates Nrf2 via the formation of its reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI), which may disrupt the repression of Nrf2 through the modification of cysteine residues within Keap1.	Acetaminophen	21-34	kelch-like ECH-associated protein 1	Mus musculus	227-232
18785192-4	2008	We hypothesized that acetaminophen activates Nrf2 via the formation of its reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI), which may disrupt the repression of Nrf2 through the modification of cysteine residues within Keap1.	N-acetyl-4-benzoquinoneimine	95-123	kelch-like ECH-associated protein 1	Mus musculus	227-232
18785192-4	2008	We hypothesized that acetaminophen activates Nrf2 via the formation of its reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI), which may disrupt the repression of Nrf2 through the modification of cysteine residues within Keap1.	N-acetyl-4-benzoquinoneimine	125-130	kelch-like ECH-associated protein 1	Mus musculus	227-232
18785192-4	2008	We hypothesized that acetaminophen activates Nrf2 via the formation of its reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI), which may disrupt the repression of Nrf2 through the modification of cysteine residues within Keap1.	Cysteine	202-210	kelch-like ECH-associated protein 1	Mus musculus	227-232
18785192-6	2008	Furthermore, mass spectrometric analysis shows that NAPQI selectively modifies cysteine residues in Keap1, both in recombinant protein in vitro and in cells ectopically expressing Keap1.	N-acetyl-4-benzoquinoneimine	52-57	kelch-like ECH-associated protein 1	Mus musculus	100-105
18785192-6	2008	Furthermore, mass spectrometric analysis shows that NAPQI selectively modifies cysteine residues in Keap1, both in recombinant protein in vitro and in cells ectopically expressing Keap1.	N-acetyl-4-benzoquinoneimine	52-57	kelch-like ECH-associated protein 1	Mus musculus	180-185
18785192-6	2008	Furthermore, mass spectrometric analysis shows that NAPQI selectively modifies cysteine residues in Keap1, both in recombinant protein in vitro and in cells ectopically expressing Keap1.	Cysteine	79-87	kelch-like ECH-associated protein 1	Mus musculus	100-105
18057000-6	2008	Similarly, cysteine residues corresponding to Cys-273 and Cys-288 in the intervening region of mouse Keap1, which are essential for the repression of Nrf2 activity in cultured cells, are conserved among Keap1 orthologs in vertebrates and invertebrates, except fish.	Cysteine	46-49	kelch-like ECH-associated protein 1	Mus musculus	101-106
18512965-8	2008	Activation of Nrf2 by Cd involved stabilization of the Nrf2 protein, increased formation of Nrf2/Keap1 complex in the cytoplasm, translocation of the complex into the nucleus, and subsequently disruption of the complex.	Cadmium	22-24	kelch-like ECH-associated protein 1	Mus musculus	97-102
18512965-10	2008	The study provided a mechanistic transcriptional model in which Cd activates Nrf2 through a metal-activated signaling pathway involving a dynamic interplay between ubiquitination/deubiquitination and complex formation/dissociation of Nrf2 and Keap1.	Cadmium	64-66	kelch-like ECH-associated protein 1	Mus musculus	243-248
18512965-10	2008	The study provided a mechanistic transcriptional model in which Cd activates Nrf2 through a metal-activated signaling pathway involving a dynamic interplay between ubiquitination/deubiquitination and complex formation/dissociation of Nrf2 and Keap1.	Metals	92-97	kelch-like ECH-associated protein 1	Mus musculus	243-248
18268004-0	2008	Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity.	Cysteine	39-47	kelch-like ECH-associated protein 1	Mus musculus	60-65
18268004-3	2008	Keap1 possesses several reactive cysteine residues that covalently bond with electrophiles in vitro.	Cysteine	33-41	kelch-like ECH-associated protein 1	Mus musculus	0-5
18268004-4	2008	To clarify the functional significance of each Keap1 cysteine residue under physiological conditions, we established a transgenic complementation rescue model.	Cysteine	53-61	kelch-like ECH-associated protein 1	Mus musculus	47-52
18268004-8	2008	These results demonstrate critical roles of the cysteine residues in vivo in maintaining Keap1 function, such that Nrf2 is repressed under quiescent conditions and active in response to oxidants/electrophiles.	Cysteine	48-56	kelch-like ECH-associated protein 1	Mus musculus	89-94
18057000-6	2008	Similarly, cysteine residues corresponding to Cys-273 and Cys-288 in the intervening region of mouse Keap1, which are essential for the repression of Nrf2 activity in cultured cells, are conserved among Keap1 orthologs in vertebrates and invertebrates, except fish.	Cysteine	11-19	kelch-like ECH-associated protein 1	Mus musculus	101-106
18057000-6	2008	Similarly, cysteine residues corresponding to Cys-273 and Cys-288 in the intervening region of mouse Keap1, which are essential for the repression of Nrf2 activity in cultured cells, are conserved among Keap1 orthologs in vertebrates and invertebrates, except fish.	Cysteine	11-19	kelch-like ECH-associated protein 1	Mus musculus	203-208
18329808-9	2008	Thus, the most potent active form as the activator of the Keap1/Nrf2 pathway, the quinone-type CA, will be produced inside the cells.	quinone	82-89	kelch-like ECH-associated protein 1	Mus musculus	58-63
18057000-6	2008	Similarly, cysteine residues corresponding to Cys-273 and Cys-288 in the intervening region of mouse Keap1, which are essential for the repression of Nrf2 activity in cultured cells, are conserved among Keap1 orthologs in vertebrates and invertebrates, except fish.	Cysteine	46-49	kelch-like ECH-associated protein 1	Mus musculus	203-208
18057000-6	2008	Similarly, cysteine residues corresponding to Cys-273 and Cys-288 in the intervening region of mouse Keap1, which are essential for the repression of Nrf2 activity in cultured cells, are conserved among Keap1 orthologs in vertebrates and invertebrates, except fish.	Cysteine	58-61	kelch-like ECH-associated protein 1	Mus musculus	101-106
18057000-6	2008	Similarly, cysteine residues corresponding to Cys-273 and Cys-288 in the intervening region of mouse Keap1, which are essential for the repression of Nrf2 activity in cultured cells, are conserved among Keap1 orthologs in vertebrates and invertebrates, except fish.	Cysteine	58-61	kelch-like ECH-associated protein 1	Mus musculus	203-208
18057000-10	2008	Individual mutation of either residual cysteine residue in Keap1a and Keap1b disrupted the ability of Keap1 to repress Nrf2, indicating that the presence of either Cys-273 or Cys-288 is sufficient for fish Keap1 molecules to fully function.	Cysteine	39-47	kelch-like ECH-associated protein 1	Mus musculus	59-64
18057000-11	2008	These results provide an important insight into the means by which Keap1 cysteines act as sensors of electrophiles and oxidants.	Cysteine	73-82	kelch-like ECH-associated protein 1	Mus musculus	67-72
17903176-5	2007	This subcellular localization profile of Keap1 appears unchanged after treatment of cells with diethyl maleate, an electrophile, and/or Leptomycin B, a nuclear export inhibitor.	diethyl maleate	95-110	kelch-like ECH-associated protein 1	Mus musculus	41-46
17903176-5	2007	This subcellular localization profile of Keap1 appears unchanged after treatment of cells with diethyl maleate, an electrophile, and/or Leptomycin B, a nuclear export inhibitor.	leptomycin B	136-148	kelch-like ECH-associated protein 1	Mus musculus	41-46
17903176-8	2007	Analyses of sucrose density gradient centrifugation of mouse liver cells indicated that Keap1 appears to form multiprotein complexes in the cytoplasm.	Sucrose	12-19	kelch-like ECH-associated protein 1	Mus musculus	88-93
17015256-5	2006	Sulforaphane induces via activation of the Nrf2/Keap1 system phase 2 enzymes that protect against carcinogens and oxidants.	sulforaphane	0-12	kelch-like ECH-associated protein 1	Mus musculus	48-53
17420218-8	2007	In the nucleus, treatment with Cr(VI), but not phenolic antioxidant tert-butylhydroquinone, librates Nrf2 from the Nrf2/Keap1 association and recruits Nrf2 to the antioxidant response elements (ARE) located in the enhancers of Ho-1 and Nqo1.	Chromium	31-33	kelch-like ECH-associated protein 1	Mus musculus	120-125
17420218-9	2007	Activation of Nrf2 by Cr(VI) was accompanied by the nuclear translocation and deubiquitination of Keap1 implicating recycling of Keap1 in Nrf2 signaling.	Chromium	22-24	kelch-like ECH-associated protein 1	Mus musculus	98-103
17420218-9	2007	Activation of Nrf2 by Cr(VI) was accompanied by the nuclear translocation and deubiquitination of Keap1 implicating recycling of Keap1 in Nrf2 signaling.	Chromium	22-24	kelch-like ECH-associated protein 1	Mus musculus	129-134
17237276-2	2007	An imidazolide triterpenoid derivative, 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-Im or TP235), has been previously shown to potently protect against hepatic tumorigenesis, acting in part by inducing cytoprotective genes through Keap1-Nrf2-antioxidant response element (ARE) signaling.	imidazolide	3-14	kelch-like ECH-associated protein 1	Mus musculus	251-256
17237276-2	2007	An imidazolide triterpenoid derivative, 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-Im or TP235), has been previously shown to potently protect against hepatic tumorigenesis, acting in part by inducing cytoprotective genes through Keap1-Nrf2-antioxidant response element (ARE) signaling.	triterpenoid TP-222	15-27	kelch-like ECH-associated protein 1	Mus musculus	251-256
17237276-2	2007	An imidazolide triterpenoid derivative, 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-Im or TP235), has been previously shown to potently protect against hepatic tumorigenesis, acting in part by inducing cytoprotective genes through Keap1-Nrf2-antioxidant response element (ARE) signaling.	1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole	40-97	kelch-like ECH-associated protein 1	Mus musculus	251-256
17394461-9	2007	The effect of dopamine was blocked by antioxidants, and by over-expression of either dominant-negative Nrf2 or Keap1.	Dopamine	14-22	kelch-like ECH-associated protein 1	Mus musculus	111-116
16517063-1	2007	Bis(2-hydroxybenzylidene)acetone is a potent inducer of the phase 2 response through the Keap1-Nrf2-ARE pathway.	bis(2-hydroxybenzylidene)acetone	0-32	kelch-like ECH-associated protein 1	Mus musculus	89-94
16267095-9	2006	Thus NO-ASA induces phase II enzymes, at least in part, through the action of NO that it releases and by modulating the Keap1-Nrf2 pathway; this effect may be part of its mechanism of action against colon and other cancers.	Aspirin	8-11	kelch-like ECH-associated protein 1	Mus musculus	120-125
16054659-6	2005	Pharmacological and food-derived agents such as dithiolethiones and isothiocyanates trigger the release of Nrf2 from Keap1, allowing it to translocate into the nucleus and stimulate gene transcription.	dithiolethiones	48-63	kelch-like ECH-associated protein 1	Mus musculus	117-122
16507366-2	2006	To elucidate the molecular mechanism of the Keap1 and Nrf2 interaction, we resolved the six-bladed beta propeller crystal structure of the Kelch/DGR and CTR domains of mouse Keap1 and revealed that extensive inter- and intrablade hydrogen bonds maintain the structural integrity and proper association of Keap1 with Nrf2.	Hydrogen	230-238	kelch-like ECH-associated protein 1	Mus musculus	44-49
16054659-6	2005	Pharmacological and food-derived agents such as dithiolethiones and isothiocyanates trigger the release of Nrf2 from Keap1, allowing it to translocate into the nucleus and stimulate gene transcription.	Isothiocyanates	68-83	kelch-like ECH-associated protein 1	Mus musculus	117-122
15767573-6	2005	The direct interaction of this TP with thiol groups of the Keap1 sensor for inducers is demonstrated spectroscopically.	tp	31-33	kelch-like ECH-associated protein 1	Mus musculus	59-64
15865434-3	2005	The primary sensors for inducers are certain uniquely reactive cysteine thiols of Keap1.	cysteine thiols	63-78	kelch-like ECH-associated protein 1	Mus musculus	82-87
15865434-4	2005	Recombinant murine Keap1 contains 0.9 zinc atoms per monomer as determined by inductively coupled plasma-optical emission spectrometry: its zinc content depends on the metal composition of the overexpression medium.	Metals	168-173	kelch-like ECH-associated protein 1	Mus musculus	19-24
15865434-7	2005	Coincident binding of inducers and release of zinc alters the conformation of Keap1, as shown by a profound decline of its tryptophan fluorescence and depression of fluorescence of a hydrophobicity probe.	Tryptophan	123-133	kelch-like ECH-associated protein 1	Mus musculus	78-83
15865434-8	2005	Thus, regulation of the phase 2 response involves chemical modification of critical cysteine residues of Keap1, whose reactivity is modulated by zinc binding.	Cysteine	84-92	kelch-like ECH-associated protein 1	Mus musculus	105-110
15865434-9	2005	Keap1 is a zinc-thiol protein endowed with a delicate switch controlled by both metal-binding and thiol reactivity.	Sulfhydryl Compounds	16-21	kelch-like ECH-associated protein 1	Mus musculus	0-5
15865434-9	2005	Keap1 is a zinc-thiol protein endowed with a delicate switch controlled by both metal-binding and thiol reactivity.	Metals	80-85	kelch-like ECH-associated protein 1	Mus musculus	0-5
15865434-9	2005	Keap1 is a zinc-thiol protein endowed with a delicate switch controlled by both metal-binding and thiol reactivity.	Sulfhydryl Compounds	98-103	kelch-like ECH-associated protein 1	Mus musculus	0-5
15767573-6	2005	The direct interaction of this TP with thiol groups of the Keap1 sensor for inducers is demonstrated spectroscopically.	Sulfhydryl Compounds	39-44	kelch-like ECH-associated protein 1	Mus musculus	59-64
15110385-8	2004	Recent analyses argue that the redox mechanism that modifies cysteine residues of Keap1 governs the Keap1-Nrf2 interaction and therefore is critical for sensing of electrophiles.	Cysteine	61-69	kelch-like ECH-associated protein 1	Mus musculus	82-87
16508120-2	2005	The Kelch/DGR (double-glycine repeat) domain of Keap1 associates with Nrf2 as well as with actin filaments.	Glycine	22-29	kelch-like ECH-associated protein 1	Mus musculus	48-53
15110385-8	2004	Recent analyses argue that the redox mechanism that modifies cysteine residues of Keap1 governs the Keap1-Nrf2 interaction and therefore is critical for sensing of electrophiles.	Cysteine	61-69	kelch-like ECH-associated protein 1	Mus musculus	100-105
15122755-6	2004	Activation of Nrf2 is considered to involve dissociation from a cytoplasmic inhibitor, Kelch-like ECH-associated protein 1 (Keap1), through a redox-sensitive mechanism involving either GSH depletion or direct chemical interaction through Michael addition.	Glutathione	185-188	kelch-like ECH-associated protein 1	Mus musculus	87-122
15122755-9	2004	In conclusion, GSH depletion alone is insufficient for Nrf2 activation: a more direct interaction is required, possibly involving chemical modification of Nrf2 or Keap1, which is facilitated by the prior loss of GSH.	Glutathione	212-215	kelch-like ECH-associated protein 1	Mus musculus	163-168
14764894-0	2004	Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers.	Cysteine	97-106	kelch-like ECH-associated protein 1	Mus musculus	114-119
14764894-3	2004	Under basal conditions, Nrf2 resides mainly in the cytoplasm bound to its cysteine-rich, Kelch domain-containing partner Keap1, which is itself anchored to the actin cytoskeleton and represses Nrf2 activity.	Cysteine	74-82	kelch-like ECH-associated protein 1	Mus musculus	121-126
14764894-4	2004	Inducers disrupt the Keap1-Nrf2 complex by modifying two (C273 and C288) of the 25 cysteine residues of Keap1.	Cysteine	83-91	kelch-like ECH-associated protein 1	Mus musculus	21-26
14764894-4	2004	Inducers disrupt the Keap1-Nrf2 complex by modifying two (C273 and C288) of the 25 cysteine residues of Keap1.	Cysteine	83-91	kelch-like ECH-associated protein 1	Mus musculus	104-109
14764894-6	2004	Reaction of Keap1 with inducers results in formation of intermolecular disulfide bridges, probably between C273 of one Keap1 molecule and C288 of a second.	Disulfides	71-80	kelch-like ECH-associated protein 1	Mus musculus	12-17
14764894-6	2004	Reaction of Keap1 with inducers results in formation of intermolecular disulfide bridges, probably between C273 of one Keap1 molecule and C288 of a second.	Disulfides	71-80	kelch-like ECH-associated protein 1	Mus musculus	119-124
12193649-4	2002	We cloned, overexpressed, and purified murine Keap1 and demonstrated on native gels the formation of complexes of Keap1 with the Neh2 domain of Nrf2 and their concentration-dependent disruption by inducers such as sulforaphane and bis(2-hydroxybenzylidene)acetone.	sulforaphane	214-226	kelch-like ECH-associated protein 1	Mus musculus	46-51
12193649-4	2002	We cloned, overexpressed, and purified murine Keap1 and demonstrated on native gels the formation of complexes of Keap1 with the Neh2 domain of Nrf2 and their concentration-dependent disruption by inducers such as sulforaphane and bis(2-hydroxybenzylidene)acetone.	sulforaphane	214-226	kelch-like ECH-associated protein 1	Mus musculus	114-119
12193649-4	2002	We cloned, overexpressed, and purified murine Keap1 and demonstrated on native gels the formation of complexes of Keap1 with the Neh2 domain of Nrf2 and their concentration-dependent disruption by inducers such as sulforaphane and bis(2-hydroxybenzylidene)acetone.	bis(2-hydroxybenzylidene)acetone	231-263	kelch-like ECH-associated protein 1	Mus musculus	46-51
12193649-4	2002	We cloned, overexpressed, and purified murine Keap1 and demonstrated on native gels the formation of complexes of Keap1 with the Neh2 domain of Nrf2 and their concentration-dependent disruption by inducers such as sulforaphane and bis(2-hydroxybenzylidene)acetone.	bis(2-hydroxybenzylidene)acetone	231-263	kelch-like ECH-associated protein 1	Mus musculus	114-119
12193649-6	2002	With large excesses of these reagents nearly all thiols of Keap1 react, but sequential reaction with three successive single equivalents (per cysteine residue) of dipyridyl disulfides revealed excellent agreement with pseudo-first order kinetics, rapid successive declines in reaction velocity, and the stoichiometric formation of two equivalents of thiopyridone per reacted cysteine.	Sulfhydryl Compounds	49-55	kelch-like ECH-associated protein 1	Mus musculus	59-64
12193649-8	2002	The most reactive residues of Keap1 (C(257), C(273), C(288), and C(297)) were identified by mapping the dexamethasone-modified cysteines by mass spectrometry of tryptic peptides.	Dexamethasone	104-117	kelch-like ECH-associated protein 1	Mus musculus	30-35
12193649-8	2002	The most reactive residues of Keap1 (C(257), C(273), C(288), and C(297)) were identified by mapping the dexamethasone-modified cysteines by mass spectrometry of tryptic peptides.	Cysteine	127-136	kelch-like ECH-associated protein 1	Mus musculus	30-35
12193649-8	2002	The most reactive residues of Keap1 (C(257), C(273), C(288), and C(297)) were identified by mapping the dexamethasone-modified cysteines by mass spectrometry of tryptic peptides.	Peptides	169-177	kelch-like ECH-associated protein 1	Mus musculus	30-35
12193649-9	2002	These residues are located in the intervening region between BTB and Kelch repeat domains of Keap1 and probably are the direct sensors of inducers of the phase 2 system.	btb	61-64	kelch-like ECH-associated protein 1	Mus musculus	93-98
12653965-2	2003	Several lines of evidence suggest that electrophiles and reactive oxygen species liberate Nrf2 from its cytoplasmic repressor Keap1 and provoke the accumulation of Nrf2 in the nucleus.	Reactive Oxygen Species	57-80	kelch-like ECH-associated protein 1	Mus musculus	126-131
12506115-0	2003	Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway.	dithiolethiones	56-71	kelch-like ECH-associated protein 1	Mus musculus	84-89
12506115-11	2003	Collectively, D3T increases the expression of genes through the Keap1-Nrf2 signaling pathway that directly detoxify toxins and generate essential cofactors such as glutathione and reducing equivalents.	Glutathione	164-175	kelch-like ECH-associated protein 1	Mus musculus	64-69