PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33433063-7	2021	In addition, we identified that inhibition of SOX2-OT and reduced expression of SOX2/GLI-1 sensitizes lung cancer cells to EGFR/TKI-erlotinib or cisplatin-based treatment.	Cisplatin	145-154	SOX2 overlapping transcript	Homo sapiens	46-53
34607512-7	2021	The expression levels of lncRNA SOX2-OT and NAIF1 were increased, and miR-942-5p expression was decreased in SH-SY5Y cells following MPP+ treatment.	mangion-purified polysaccharide (Candida albicans)	133-137	SOX2 overlapping transcript	Homo sapiens	32-39
34607512-10	2021	Overall, lncRNA SOX2-OT-mediated regulation of oxidative stress, inflammation, and neuronal apoptosis were directly controlled by the miR-942-5p/NAIF1 signal axis in MPP+-induced SH-SY5Y cells.	mangion-purified polysaccharide (Candida albicans)	166-170	SOX2 overlapping transcript	Homo sapiens	16-23
34322386-14	2021	Downregulating miR-143-3p or upregulating MSI2 averted the role of si-SOX2-OT in HCC cells.	Silicon	67-69	SOX2 overlapping transcript	Homo sapiens	70-77
34531671-1	2021	Purpose: LncRNA SOX2OT plays protective roles in high glucose-induced injuries, suggesting its potential involvement in diabetes.	Glucose	54-61	SOX2 overlapping transcript	Homo sapiens	16-22
34967264-2	2022	This work intended to explore the functions of lncRNA SOX2-OT and its regulatory mechanism within MI/R-induced injury.	Arginine	101-102	SOX2 overlapping transcript	Homo sapiens	54-61
34967264-7	2022	SOX2-OT knockdown attenuated oxygen-glucose deprivation/reoxygenation (OGD/R)-induced cardiomyocyte dysregulation through relieving inflammation, promoting proliferation, and reducing apoptosis in OGD/R-treated H2C9 cells.	Oxygen	29-35	SOX2 overlapping transcript	Homo sapiens	0-7
33895495-3	2021	The results showed that lncRNA SOX2 overlapping transcript (SOX2-OT) was significantly induced in HBE cells exposed to PM2.5, DEPs, or Al2O3 NPs, acting as a sponge to microRNA-345-5p, which subsequently increased the expression levels of epidermal growth factor receptor (EGFR).	Aluminum Oxide	135-140	SOX2 overlapping transcript	Homo sapiens	60-67
31301307-0	2019	LncRNA SOX2OT alleviates the high glucose-induced podocytes injury through autophagy induction by the miR-9/SIRT1 axis.	Glucose	34-41	SOX2 overlapping transcript	Homo sapiens	7-13
32439916-0	2020	LncRNA SOX2OT promotes temozolomide resistance by elevating SOX2 expression via ALKBH5-mediated epigenetic regulation in glioblastoma.	Temozolomide	23-35	SOX2 overlapping transcript	Homo sapiens	7-13
32439916-3	2020	Here, we found that LncRNA SOX2OT was increased in TMZ-resistant cells and recurrent GBM patient samples, and abnormal expression was correlated with high risk of relapse and poor prognosis.	Temozolomide	51-54	SOX2 overlapping transcript	Homo sapiens	27-33
32439916-4	2020	Knockdown of SOX2OT suppressed cell proliferation, facilitated cell apoptosis, and enhanced TMZ sensitivity.	Temozolomide	92-95	SOX2 overlapping transcript	Homo sapiens	13-19
32439916-5	2020	In addition, we identified that SOX2OT regulated TMZ sensitivity by increasing SOX2 expression and further activating the Wnt5a/beta-catenin signaling pathway in vitro and in vivo.	Temozolomide	49-52	SOX2 overlapping transcript	Homo sapiens	32-38
32439916-7	2020	Together, these results demonstrated that LncRNA SOX2OT inhibited cell apoptosis, promoted cell proliferation, and TMZ resistance by upregulating SOX2 expression, which activated the Wnt5a/beta-catenin signaling pathway.	Temozolomide	115-118	SOX2 overlapping transcript	Homo sapiens	49-55
32439916-8	2020	Our findings indicate that LncRNA SOX2OT may serve as a novel biomarker for GBM prognosis and act as a therapeutic target for TMZ treatment.	Temozolomide	126-129	SOX2 overlapping transcript	Homo sapiens	34-40
33433063-4	2021	We detected that the SOX2-OT/SOX2/GLI-1 axis promotes resistance to tyrosine kinase inhibitor (TKI)-erlotinib and cisplatin-based therapy.	Erlotinib Hydrochloride	100-109	SOX2 overlapping transcript	Homo sapiens	21-28
33433063-4	2021	We detected that the SOX2-OT/SOX2/GLI-1 axis promotes resistance to tyrosine kinase inhibitor (TKI)-erlotinib and cisplatin-based therapy.	Cisplatin	114-123	SOX2 overlapping transcript	Homo sapiens	21-28
33433063-7	2021	In addition, we identified that inhibition of SOX2-OT and reduced expression of SOX2/GLI-1 sensitizes lung cancer cells to EGFR/TKI-erlotinib or cisplatin-based treatment.	Erlotinib Hydrochloride	132-141	SOX2 overlapping transcript	Homo sapiens	46-53
31301307-2	2019	This study aims to investigate the role of long non-coding RNA SOX2OT in the high glucose (HG)-induced injury of human podocytes cells (HPCs) and the underlying mechanism.	Glucose	82-89	SOX2 overlapping transcript	Homo sapiens	63-69
31301307-6	2019	RESULTS: SOX2OT overexpression significantly alleviated the HG-induced HPCs injury and induced autophagy, which was abrogated by the autophagy inhibitor 3-MA and SIRT1 knockdown.	3-methyladenine	153-157	SOX2 overlapping transcript	Homo sapiens	9-15
31667251-1	2019	The data provided in this article are related to research entitled "Efficiency of graphene oxide nanoparticles as delivery system of SOX2OT siRNA".	Graphite	82-96	SOX2 overlapping transcript	Homo sapiens	133-139
27904704-5	2016	The biological function of Sox2ot on tumor cell growth and mobility were explored through MTT, colony formation, Transwell migration assay and invasion assay in vitro.	monooxyethylene trimethylolpropane tristearate	90-93	SOX2 overlapping transcript	Homo sapiens	27-33
29643475-6	2018	Sox2ot competitively binds to the miR-200 family to regulate the expression of Sox2, thus promoting invasion and metastasis of PDAC.	mir-200	34-41	SOX2 overlapping transcript	Homo sapiens	0-6
29475441-0	2018	SOX2OT variant 7 contributes to the synergistic interaction between EGCG and Doxorubicin to kill osteosarcoma via autophagy and stemness inhibition.	epigallocatechin gallate	68-72	SOX2 overlapping transcript	Homo sapiens	0-6
29475441-0	2018	SOX2OT variant 7 contributes to the synergistic interaction between EGCG and Doxorubicin to kill osteosarcoma via autophagy and stemness inhibition.	Doxorubicin	77-88	SOX2 overlapping transcript	Homo sapiens	0-6
29475441-9	2018	RESULTS: We found that EGCG targeting LncRNA SOX2OT variant 7 produced synergistic effects with Doxorubicin on osteosarcoma cell growth inhibition.	epigallocatechin gallate	23-27	SOX2 overlapping transcript	Homo sapiens	45-51
29475441-9	2018	RESULTS: We found that EGCG targeting LncRNA SOX2OT variant 7 produced synergistic effects with Doxorubicin on osteosarcoma cell growth inhibition.	Doxorubicin	96-107	SOX2 overlapping transcript	Homo sapiens	45-51
29475441-10	2018	On the one hand, EGCG could reduce the Doxorubicin-induced pro-survival autophagy through decreasing SOX2OT variant 7 to improve the growth inhibition of Doxorubicin.	epigallocatechin gallate	17-21	SOX2 overlapping transcript	Homo sapiens	101-107
29475441-10	2018	On the one hand, EGCG could reduce the Doxorubicin-induced pro-survival autophagy through decreasing SOX2OT variant 7 to improve the growth inhibition of Doxorubicin.	Doxorubicin	39-50	SOX2 overlapping transcript	Homo sapiens	101-107
29475441-10	2018	On the one hand, EGCG could reduce the Doxorubicin-induced pro-survival autophagy through decreasing SOX2OT variant 7 to improve the growth inhibition of Doxorubicin.	Doxorubicin	154-165	SOX2 overlapping transcript	Homo sapiens	101-107
29475441-11	2018	On the other hand, EGCG could partially inactivate Notch3/DLL3 signaling cascade targeting SOX2OT variant 7 to reduce the stemness then abated drug-resistance of osteosarcoma cells.	epigallocatechin gallate	19-23	SOX2 overlapping transcript	Homo sapiens	91-97
30145837-0	2018	Downregulation of long noncoding RNA Sox2ot protects PC-12 cells from hydrogen peroxide-induced injury in spinal cord injury via regulating the miR-211-myeloid cell leukemia-1 isoform2 axis.	Hydrogen Peroxide	70-87	SOX2 overlapping transcript	Homo sapiens	37-43
30145837-1	2018	This study aimed to investigate the effects and possible mechanisms of long noncoding RNA (lncRNA) Sox2 overlapping transcript (Sox2ot) on hydrogen peroxide (H2 O2 )-induced injury in pheochromocytoma (PC-12) cells.	Hydrogen Peroxide	139-156	SOX2 overlapping transcript	Homo sapiens	128-134
30145837-1	2018	This study aimed to investigate the effects and possible mechanisms of long noncoding RNA (lncRNA) Sox2 overlapping transcript (Sox2ot) on hydrogen peroxide (H2 O2 )-induced injury in pheochromocytoma (PC-12) cells.	Hydrogen Peroxide	158-163	SOX2 overlapping transcript	Homo sapiens	128-134
30145837-6	2018	Suppression of Sox2ot inhibited H2 O2 -induced PC-12 cell injury by increasing cell viability, migration, invasion, and decreasing apoptosis and autophagy.	Hydrogen Peroxide	32-37	SOX2 overlapping transcript	Homo sapiens	15-21
30145837-7	2018	Moreover, suppression of Sox2ot increased miR-211 expression and alleviated H2 O2 -induced injury in PC-12 cells possibly via upregulation of miR-211.	Hydrogen Peroxide	76-81	SOX2 overlapping transcript	Homo sapiens	25-31
30145837-11	2018	Our findings indicate that downregulation of Sox2ot may protect PC-12 cells from H2 O2 -induced injury in SCI via targeting the miR-211/MCL-1 isoform2 axis.	Hydrogen Peroxide	81-86	SOX2 overlapping transcript	Homo sapiens	45-51
28314692-6	2017	Further distinguishing features of this "CIMP-Atypical" subtype include an antiviral gene expression profile associated with pro-inflammatory M1 macrophages and CD8+ T cell infiltration, CASP8 mutations, and a well-differentiated state corresponding to normal SOX2 copy number and SOX2OT hypermethylation.	Cyclic IMP	41-45	SOX2 overlapping transcript	Homo sapiens	281-287